<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDJ1</accession>
    <name>A0A2R6NDJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NDJ1"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="629"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="865" mass="96494" checksum="2249D7706AFC50A7" modified="2018-06-20" version="1">MPPKGPWWKLFDDKVDGKVVKYLGDKTKNSALAGQTVGRRERHNVTDAGVIPVCAKKEYMAAHGRACPYADPAGVALALEEDAADAANRARRYANSENMSPVPGLTQTPRTPLHSIPLNPSIYDTSTQTPLKRAKTSSLESIPGTSDSSGTLYYQNDSHPPPWNASRQKEFSEDLCKLFIMCNIAWNVAENAQLHLFFHKWVPGAVIPDRRKLSGTYLDEAADQVRSETVKKVQGSLGTGQSDGWKNVAKTSVVASMMSVNGEAHLVRTHDMTGEPKSGDKAFELIQWDIKYIWEVFRVFIIAWCTDDGPDGKKARRLISRDMAWIITTVCWAHQINLIVGDYLTLGPYLDIVTRALEIIKWFNNHGTALDLFKREQSITYPDRTRILALILPVITRWTAHFHSASRLLLLSKAIKMCVARNEEKLLLCAGKTKDVISKAQQILDTVKNEQFWLELVKVKMHLEPLAIAANVTQAPYTRLDHVLLTLANLYRIYKFGDADEIVRIRILESLEKRWKKADQDVLILAVLFNPYIRARCFNREVISTGDLISIAKRTFTRLFRTSPESSFTTGLLDYIERRKEFSDDAMQIEDYRCEAHVESKDIPIVNIWRMADRSNVEPTEPCTDRNGVVRIAIRILSVIANSASCERIFSDFGMTHTKRRNRLSPQIVHKTALVRMALGREHAAAGLTSKRLKRKFGYEHPNTSSESIPPTTTSASSSAAVTITATNANSGASEDVSIDFNEIGQELIRDAIIAQASPEDDDLEDPVTAAVTMTGGNDIQVVPTTGANTAVASQSRANKEKKTSIPLSLLFIYPTSVTSLPGGVDNTTVASEDGLDFFWSGGFRNYTQELTLYDLIHTETPNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDW6</accession>
    <name>A0A2R6NDW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v13538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001348">
        <property type="protein sequence ID" value="PSR70567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDW6"/>
    <dbReference type="STRING" id="98765.A0A2R6NDW6"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR70567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="580" mass="63923" checksum="3E6252FA06E36D09" modified="2018-06-20" version="1" fragment="single">ANDPDFFWLGRVPCRTVLFYGMVIGVQDYEQRTVYTVDDGSGAIGCNWRYSKQQPATQRMSPVKNGTSKRHQTSQKYASTSTLIVGTGLPVRPKPMAHVGDIVRVAGHVLNRHQTRLVNLDKIEVCKSANVEPLHWINVIELHQSWYHATDAGPFVIPALKVTAALSDTTRDGRSQSQLQNVRDSQSQSPSRSSIASSAPSSPSSVTSNVSSSVAQHYMDNAAPNSLSDESQSDDDDAEPRTPTKRRKKAVMLISDETPRASSKQPRTEAGVDSNETPRRPSSSYTTNAQRSSNGKCASDEGDPFMKGYTLSHLRRVPELATLARRVVDAESKRRVREERKKQKEEEAAKGSTSTSSSMHRSSRTDKSRNSKESEPRNAKMKRLFRFAIRQLYEEGSIVLWDGPVRALPSPPPARLFTASSVSMPSSLWKSSASTAGDSTGLSLMSTNTSLITMQETEEDQSYWSDPPANEESYIPLTPAYLCHVVEGAIASIVARRSQASRQGHSSIAGLNGVDLAKRISGNRPAGPTAGEIVDYLKKRDERWMRVGEWAVKEALEWGMERGRVWCLSGGRWEVCGLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEB7</accession>
    <name>A0A2R6NEB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001334">
        <property type="protein sequence ID" value="PSR70713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEB7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="5960" checksum="93552E051738D305" modified="2018-06-20" version="1">MKDIPKAKRPENAPVIFIYSVKETLAERSASTCSGRTPPEQPEAELEHMAGIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFM8</accession>
    <name>A0A2R6NFM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFM8"/>
    <dbReference type="STRING" id="98765.A0A2R6NFM8"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="22842" checksum="65853D22B243B23C" modified="2018-06-20" version="1">MHNAASLPGSKHEHSLSISPDALPPVWSTKQETDTCYNECARLLIETLAADIKNSNASRQSHSWSSLFGLFGSNSGRSKVPTLGILFGTHNWTSCRLVLDELLKRGLASVEGVTVEGEPIVKIGGEVTERLTMAQLYGMHDHLTNYLVERTRTSSPFVIKYVPYGSLKDVMPYLSRRAIENKSVLGEGAAIDERQRAWALIRGRVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFS0</accession>
    <name>A0A2R6NFS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFS0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="10675" checksum="B7DE03626CF76F1C" modified="2018-06-20" version="1">MANFHVPTLINVAANMGDSLAYHGEYEEYVEEDFSDDGTDLSSEISTITDICGPCDVYLHNVEVYKRYGELSHSHEPSEVGTNLGGLKSMELAENNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFU2</accession>
    <name>A0A2R6NFU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFU2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7411" checksum="C1624DB9F8AD92B4" modified="2018-06-20" version="1">MAHLEFFRITDVTERISENKMCFKETEDGMVDVEAGPEDDMSKQSRLQRFCVIWRNKVALTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGN7</accession>
    <name>A0A2R6NGN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGN7"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="860" mass="93562" checksum="9EEC7EA098DAD3D3" modified="2018-06-20" version="1">MLAAASSFFGRTNISQSYNIGPSSTGSRTSTPAPSASSVTLPAAAHAPPFNVGPWRVQSANHKVTGKRVSVWSVDKRSQEMERVGAVSRERTLEVLKAEATALGRLRHPSILEMVEPLEETRNELIFATEPVLSSLHLSIPGSLQYSPLVELDEVEIQKGILQLCKGLIFLHTSARLIHTNITPESVLINSSGDWKIAGLGLTIPLTGPDGHPSRWEFPTFDGRVPPYTQRSFDYIAPEYALDEVLDPASDMYSLGCLMYAVHCKGVPPFKNHGSLGGVRDNAGKPLVGMDRLDPDLRVVLNSLITRHPHSRPSPSTLPSDAFFSSLPISTLNFLDRSNFAAKSREEKISFMKGLTSVLERFSEGLRTRKILPSLLEEMKDTQLLPYILPNVFAISHILSPPQFASLVLPSLKPLFAVKEPPQNMITLLDNLQMLQNKTEKLVFREHVLPLVYNAMESDHAIVQERALKAVPNLCETIDYAEVQGVLFPRVALVFTKTRILSVKVATLITFLSMVKTLDQSSLTQKLVPLLSKIRTKEPAVMMATLGVHEAMGLKVDREAVATLVLPQLWAMSMGPLLSVSQFKRFMEVIKKLGDRVEKEHDQYLRDSQRIEDRSSTAVNDTSTPNMGGGVDFESLVGGNGSVAVKADTVIDGAQNWDDDVWGSIFNSSDSPAMSSPPIPPPPHNLQQESQSLPSSPRIANPPANSFSRPTPTPRMSRGMGATPISASSYNASMFTPPPQSRPSLPTQSRSSLATSPPLMPQTSQQTAPSSGYAAQSQSSAPNYNISLSSVPVVSHAASMAPIMPTQPMVPSMASPPLFAASNMTSVLAPSKLSQPSWSTASNHPKQLTKDDWGDFDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH16</accession>
    <name>A0A2R6NH16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001256">
        <property type="protein sequence ID" value="PSR71674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH16"/>
    <dbReference type="STRING" id="98765.A0A2R6NH16"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="15534" checksum="989C751D8785B51E" modified="2018-06-20" version="1">MAELVLKNGGIVIATLRKPEVLSDLKAQYPGDRLLVLKLDVTRPHEIVDTFAKAKEAFGRIDVVFNNAGYSVLAEVEGTPEEQARAMFDVNFWGATNVSREAVKFFREVNKPTGGRLINVSSIVGLKVAPALGYYTATKHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHE5</accession>
    <name>A0A2R6NHE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHE5"/>
    <dbReference type="STRING" id="98765.A0A2R6NHE5"/>
    <dbReference type="OrthoDB" id="2596179at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="14427" checksum="9523DAB344EE6F3C" modified="2018-06-20" version="1">MTTRYIPHIVYTLAITSLGAHLLYHRKEAEDQRAHYTARIALLEEVAGRLRAGKPVPERDFELIRKLAKEPGMDRATARGVEVNDNIEWREVLLGRKGDGSSEKWETQDWENGARRTILRATTLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHG2</accession>
    <name>A0A2R6NHG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001244">
        <property type="protein sequence ID" value="PSR71763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHG2"/>
    <dbReference type="STRING" id="98765.A0A2R6NHG2"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015346594" description="Glycoside hydrolase family 16 protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="38673" checksum="798AFDC36C970A5D" modified="2018-06-20" version="1">MRCVSFGLLLASSLAPRAIAATYGLTDNHVGSDFLTSFTHEAIADPTNGRVNYVDQATALSLNLTYASGDTLILRSDDTTVLSPSGPGRNSVRILSTKTYTTHVAVYVLFMFPEMARDKRIYLTIPVALTCVTCHKDVELGPPLGKQMGTTGPMAEKSISIEGVNDQSPNSMTLHTGADCTMPATRTMTGSATGDNCDVNTDGNSGCGVQASTAQSYGPSFNAIGGGIYAMERTNDFINVWFWPRNVAGMPSDASSGANSIITDAWGTPTASFPNTDCDIGSHFDENNIIINLTFWYTAGGDWAGIDSIFNGAGCPGDCVGACLNFSIFGTVQLLTQRSTDFVNNNPSAFSEAFWDIAAVRVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHI9</accession>
    <name>A0A2R6NHI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001241">
        <property type="protein sequence ID" value="PSR71856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHI9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="152" mass="17274" checksum="C7524AA110673088" modified="2018-06-20" version="1">MPPYRSNRNNCIDGSRRRVYNTTRLTCPDCKGVYRNLSGLSKHRNTFHARPFGHSMTILGRQQPTTQQPQDGSTDVSQCPEPHLDDPSVLPTVHGDPENHLYEIRHKYLDGAQPSASNFSLLTQLYQDDPVISLECFSKIPTYRRLPARLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI67</accession>
    <name>A0A2R6NI67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001222">
        <property type="protein sequence ID" value="PSR72076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI67"/>
    <dbReference type="STRING" id="98765.A0A2R6NI67"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="75"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="258" mass="27779" checksum="8D69746005E76115" modified="2018-06-20" version="1">MGPTTNGGGISIPTNDAPMSGSAPGPGDDQVWSNGGRSPSRTQGDHPPRRSSRSRSPGARDGDRGRGEGGNNPGNNLHVSGLSHRVDTRDLEQAFAKVGRVKKAQVMYDPHTRESRGFGFVTMESGEEADAAITALNGTDLMGKNMLVEKARRGRARTPTPGRYYGPPKRSEHERPYDPRPYDSRYSRGGGGGGGGGRGGHDDYPPPRARRAAYDDDYRGGGRDYDRGSYRDYDRGNDRGYDRRGGGGGGGGYDDRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIG9</accession>
    <name>A0A2R6NIG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001244">
        <property type="protein sequence ID" value="PSR71762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIG9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIG9"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="224" mass="24272" checksum="DDBA7904D27D3FDC" modified="2018-06-20" version="1">MSYDQGAGLFVTWPTSYEALVGRAELKPGEWVLVTASAGGVGIAAVQLAKALGAKVIAAASTQEKLDVSKQYGGADFVVNYSNKDWQKEVLKITGGKGVNVIYDPVGMIKDCLKCIAWKGRAIVVGFAGGRIEQLPLNLVLLKNVSIVGIHWGAYAIKEPQHIPSVWKALIDLLSSGRVKPIVYSDVFPLEKLSDGLLAIEKRKTWGKAIVRIRQEDTKEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ47</accession>
    <name>A0A2R6NJ47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ47"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ47"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="48"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="234" mass="26341" checksum="6753E92C4E1066A9" modified="2018-06-20" version="1">MVSASAWATPSTRTELIENLVSGVDRYNPSNVGILEDYLYHQIRSEEYDCLANLAILKLYQFNPDLYNPDVVINILIKALTSLPFPDFNLCISLLDERSASTNPDEPDPLPLLLPVLISLHNLLQQCRFPAFWTLYRSEKAESLRDNYTVECVGFEDSVREVVIRGVKAAFKSIRMERLGNYLNLSDEDLNGYVAKLGWSIEASTGVVSIPPNPDNQIESTVVQEQIELPLTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJC6</accession>
    <name>A0A2R6NJC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001174">
        <property type="protein sequence ID" value="PSR72480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJC6"/>
    <dbReference type="STRING" id="98765.A0A2R6NJC6"/>
    <dbReference type="OrthoDB" id="2799361at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="15220" checksum="899F49AFFA7885D0" modified="2018-06-20" version="1" fragment="single">ISSATICKIQDCLDCFHTHQKIFQTTGVCNFLSLPRQHSMMHYVWAIEQFGAPNGLCTSITESRHITVVKEPWRQSNCFEAIGQVLTINQRLHKLGAAHADFEECGMLKGNIISITLKALLQVQGESDQEDLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJS5</accession>
    <name>A0A2R6NJS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02001152">
        <property type="protein sequence ID" value="PSR72596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJS5"/>
    <dbReference type="STRING" id="98765.A0A2R6NJS5"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="725" mass="77590" checksum="47D085CE514EA50B" modified="2018-06-20" version="1">MAHPHATGPAVDNDAHLSTEDVNEAFIPPQPGPHFSSFLPSIQDTSARNSYINSTPATPDVSRPFLSEGATQDPFLDKPEDGPTGAINKPARRRWPLFVVGGAIAAVVIVLAVVLPVTLVHKHHGGGGSGSGTSDGGAHDPTATANPESPTGALTGGNGTVIQADDGSTFTYINNFGGFWVDDPQNPFNNSAKAQSYTPSLDEPWVWGEDLIRGVNLGGWLVTEPFIVPALYEKYQNVSTLPGGQAVDEWTLSIAMRNDTSPGGGIQQLEDHYKTFITEQDFAQIAGAGLNWIRLPVPYWAIEVWPGEPFLANTAWTYALKALKWARKYGLRVYFELHTAPGSQNGNNHSGRLGPINFLNGPMGVANAQRTLEYIRVLAEFVSQPEYQSVVQAFGPINEPLMGIIGRDVLDSFYLEVYDMLRTITGIGKGASMVMHDGFLGLTPWKDFLPGADRLVLDTHPYVAFGGGLDQPLDYWPPAACRAFQVNQSNIDFGPTITGEFSAAINDCGKWLKNVGANASFPDCGPWDDWPTWTQDMKDGIKSFVMASMDAMHMPGYFFWTWKIGNSTDTGIASSPMWSYQLGLENGWMPADPRDAVGTCDTLDVPFNTPFNGSYPSWQTGGAGAGTIAPTATAALEEYPPTLSNAMNANPTLLPHYTDVSANPTLPAPTFSAATTTGGDGWADAQDTMLAPAPVPGCVYPDAWAAPQESTSFVCGAAATASATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK63</accession>
    <name>A0A2R6NK63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK63"/>
    <dbReference type="STRING" id="98765.A0A2R6NK63"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="404" mass="45990" checksum="40251B07A14CDFE0" modified="2018-06-20" version="1">MEAFVASLCLVMLGLYILRKPSLSFRTLLEIIRGRSKTSGGYFSLERATSSYDNYLSMSLNELADMRYSYGKLGRGHKRIGYELGYPAKLDKLGELNEVNAKITRAIAKFARGEFPQLRNAATSSAGGDVGRVRETLKHFVRDWSREGQEERDNIFGPILNVLNQVPLDERADMKVLIPGSGLGRLAWEVSKLGFETTANELSFFMTLAFRFLVSSSATQTPNQHTIYPYINWFSHQRNNDNLFRGIAFPDELPRIGNGLNLIEGDFLELQAPRREPRINEPLQKTHSVPIGYDFIVTLFFIDTSLNVISTLEHIHSLLRPGGTWINLGPLLWTSGAQAQLELSLEEVWDLARAIGFRIHGQNNDLEIPDCYRRRTVECQYTADKRALMKWLYQAEFWVATKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKY5</accession>
    <name>A0A2R6NKY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR72996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKY5"/>
    <dbReference type="STRING" id="98765.A0A2R6NKY5"/>
    <dbReference type="OrthoDB" id="2799468at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="24251" checksum="02B88254852CAA92" modified="2018-06-20" version="1">MSTNAPMVMNAAHNDAANFGARINLKNISETEARKLMSAEHKALGYRPPPGSLAAEAQAAASKHPQTVSHVPEEQLAQAAIEDAARIKSQRGIDGIDFSAIGEAQARKLMSEEHKALGHRPPPGSLAAQAQAAAAKHPQGAAATQPLLHDLQRAALEDAAVIEGAAANGIDLNYIGEAEARKLMSEEHKALGYRPPQGSLAAAAQAAAAKHPSASAGIDAATIAKAALEDAKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKZ2</accession>
    <name>A0A2R6NKZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v11138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NKZ2"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="67"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="226" mass="25669" checksum="572AA2E15553C58F" modified="2018-06-20" version="1">MALHALVQCTAKILLDEQQEQTAFDSDWEFVHSLAQLGMEDRARSGWLGNSEPDRATWKKAYEVYCQAFQNPTSEPDKNKLARILKRPIRKEVLDYLFNYDAFLRGLGRMSLNLEAHGGVYVLHSHMNHACTPNISVRHLDQRTSLSRINAIAKTDIQPGEELFITYVNPELSLEQRRQHLLEWGFGTCKCSRCVSEEQDATRTPAAKDPAADDLERELKAGLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL97</accession>
    <name>A0A2R6NL97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001111">
        <property type="protein sequence ID" value="PSR73081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NL97"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1325" mass="151315" checksum="CBFBE05A05457681" modified="2018-06-20" version="1">MAISCCHCHATFSNARGLKSHRKGCKDRLTSVQSSVNQRNVRIKETKAKLQRREQQELRGERQDMREELNQEPELQHLEPIQEVPDVNMCSPTPPPHIQPHILPPTRSGRIRKAPRRHQDFLPSTTAGQLHAHILRHLPPPPPIAPSLPIVSDPPSPGINSEPPPVNTALNIPPVNATVFETEPNDFGLFRRYQWKPSREIVDDQTDDSLCDSPSIATAPPAVAPSPLQSFGRAIVNGIGKVPAWFTPFLNASVFRLMHWSYTGSNQKSAREIERLVHQVLLAPDFKPEDLRGFRMSREERRLDEHVPPNNASFSVDEGWHESLVKVPLPKEKTKYDSEDKVPHLEIKGVWHRKLLDVIVAAYQDKSVSQLVFLPYQLLFQDAKGEPERVYTEGYTCNTLLEEDAKIRSQPRNPDDSDDVEYSIVPLMLWSDSTHLANFGTASLWPIYLYLGNLSKYVRSKPSSFAAHHLAYIPSLPDTIQDLYQSIYNIPATKNILKFCKNHIIHAIWLLLMDDKFMHAYEHGIRVDCGDHVIRRLFPRFFTYSADYPERILLACIRFLGRCPCTTCYTLKAQVPDMGMKYDYKRRENIRRDTTFIQSLIAKARKLIFEWGKPITSKSVECKLQPFSLQPLRSAFSTRLASFGFNHYAMYAYDLLHGFELGVWKSNFTHILRVLYAEGGDSIQILNRRFRQVPTFGRDTIRRFSNNVSGMKKLAARNFEDILQCIIPCVEGLLPPALEKIVLDLLWDLAVWHALAKLRLHTDSTLQLLEKATMNLGTSVRRFGRACEDIDTRELPHEEAARGRRQAAKGKGPIATGKKRKTLNLNTSKWHDLGHVAAMIRSSGTTENYSTQVGECEHKRVKRMYARTNKRSHEGQIAAKDRREGLLVDIKKQDEEVLKRGAVKSTSHSAKSADDPSPSHDISEPQQKKKRGRPRKEYFGLRPEDDDRLPHTSFNAHHHISDSRRFAINIPKFLADNSEDPGVKGFLPALKDHILSRLTGCEFDGDERTFSDAERGSLKIVDNRLFRHKVMRVNYTTYDMRRDQDSLNPRTHADVMVLAPQEDIEDENPDLSHPYWYARIVGIFHANVKYTGPESMMANSQKIEMLWVRWFGRDLSAPGGFGKRRLHRIGFADAEQPGAFGFLDPQLVIRAVHLIPAFHYGRTSAKLGPSILRQPSEGDEDWDLYYVNIFADRDMVMRFVGGGIGHIATRAIVKIADTLRHFFKSSRRAASVANEGDGDVVVLPENEDVLQYLDEDEGNDDKEEGEELEGEEEEEEEEDEDRRSSEDEDNDDEEDEDDEDDEDEEDLGPEDESRQDEYDSGYAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLG4</accession>
    <name>A0A2R6NLG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLG4"/>
    <dbReference type="STRING" id="98765.A0A2R6NLG4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="13220" checksum="9CBE350315D0FEB8" modified="2018-06-20" version="1">MPSYDLTSQWLAEYKTPLDLAKAQREPILREKFTTGWLAWPDSTNAYLVPPSSSAIHPWEIDNEGALTALRELTTQASYWKDVAKHYASENHAEVIVQDHASCVKSICMLIISRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMP2</accession>
    <name>A0A2R6NMP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMP2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMP2"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="358" mass="39277" checksum="EBD80891859AFF1E" modified="2018-06-20" version="1">MVNYGGDEVSALVIDIGTSSLRAGYAGDDTPKAVIPTCYGFKSESIGEGDVSMAEPEEEGGASAKPEKKVKLYIGQSGPSVWRDGMQIAHPVQNSLSLSHSALPMLVQAHAKHLLTSPYHNRAGIQLLPHQLIANKQTVDTSVPPRFTLRDERVPGTTETWRAWYEAKETEEWIQSVAGVIDQGWNEQAAAQRGVRHYEFPTGYNFYFGAERLQVGEQYFTHSPQLVASNPNLPKTIPALISSALSACDPDLRQVLLGNIVLTGGGSLLSGFADRLSVELQRNVNHVYSPTLFPDNANFSHFSKYQVKIHAPGNPTERRFGGWLGGSILASLGTFHQLWISKEEWQEHGKAIVGQRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMS5</accession>
    <name>A0A2R6NMS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMS5"/>
    <dbReference type="STRING" id="98765.A0A2R6NMS5"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19582" checksum="F725026989D198A0" modified="2018-06-20" version="1">MFKLLNPLRQGARSLTTAASNYPFSNVVKFMPPPSKQPTAPLLVGKGLMTYLQETLPTPEKLKFLATYFSKRHPERILPGCVLTVFLNHAPTSFSGVVTNIRYRGADTSFVLRNIINRTGVEMQFYVNSPHLKDIKVIQRPGGGLGAKSGPTMRRAKLFYLRDSPSKMTAISAGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN38</accession>
    <name>A0A2R6NN38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine dehydratase-like alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN38"/>
    <dbReference type="STRING" id="98765.A0A2R6NN38"/>
    <dbReference type="OrthoDB" id="192663at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="9">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="14414" checksum="ABEB4B0522819BC2" modified="2018-06-20" version="1">MIPAMDFLSCYAIAVNEVNASGGRIVTSPTNGAAGIIPAVLKYIIEFVSDDPDKAIETFLLTAAAVGMLFKRGSTISAAEGGCQAEVGAVKAVTAAQLAMASDNVYSVTLDEAIEAMRLTAVDMSVKYKETSLSVSTPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNX0</accession>
    <name>A0A2R6NNX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNX0"/>
    <dbReference type="STRING" id="98765.A0A2R6NNX0"/>
    <dbReference type="OrthoDB" id="5283326at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="178" mass="18978" checksum="0F5F4013D2589FEA" modified="2018-06-20" version="1">MDRTYLAFSSVSVNPCYGSSRWNLLELFVGKGSPFTDPTGTLPAPNAHSFNVLDHALNVLFTAPFTSIQWHNFAVQVDWTNRTLAVLYSVDALPLQVVSKPAPNLSTPAGATGQGDFHFGVLKLPLVNPADTPADQGDVVHFGLQEGTTEGLLYSGVFVENASQGINIGHGAIAHPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP32</accession>
    <name>A0A2R6NP32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001009">
        <property type="protein sequence ID" value="PSR74224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP32"/>
    <dbReference type="STRING" id="98765.A0A2R6NP32"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="220" mass="24634" checksum="6C2817EBB100753D" modified="2018-06-20" version="1">MNKPSDPYPGRLYATLASFVAISILLGRRTSSVKSIAIALQSHWFITPSGTLCTEHFPPTSYWPCPLHWLYHGVLLDGIAGLEDMRAPPAAAKKVSEDARGTLTRYYDRLDKLVGAFDEYILHLSRSILPSFARVIPDATVKVMKVIEAKGCEDEKKHQKTIVDAIKVTFDVAYERTGQHPLKCLDDSPWICQDLMRIEDCASLLRHLLPPYSKISPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPD9</accession>
    <name>A0A2R6NPD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPD9"/>
    <dbReference type="STRING" id="98765.A0A2R6NPD9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="14328" checksum="8F57CF1E8EBB9793" modified="2018-06-20" version="1">MKDQPHCYTIHAFGCSNTVYKVICPQDRQKWQMLLMVNELLADHPCQETLAQVRKLKPIFTLGKKCYHWISDPLLNLDPSPAEPFEADQTAVFVREDEEVANAGAEQADPFQLDKHAEEDVKMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ03</accession>
    <name>A0A2R6NQ03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ03"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ03"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="126"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="314"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="379" mass="40443" checksum="4EB42F57006D7585" modified="2018-06-20" version="1">MSSEAKLDSREKIQENVESYTDSELNVPVSGHATLHRTMKNRHIAMISIGGVIGTGLFLGTANSLAVGGPVGLLLGYSIVGTVCYSVMVSLGEMIAYLPLPGGHITMAERFVDPAWSFTLGWNYSYGETEFAFASIKVITITGLIILGIVLDLGGGPNHDRIGFRYWKNPGPFAQFDGIGGPKGRFLAWWAVMSQAAFAFIGTEIVAIAAGEAKNPRRNIPKAIKRVYVRILLFYIGGVTIIGLLVPYTNPDLKLETSNAAKSPFVIAIKTAGIKGLPSVINAALLTSAWSAASSDLYSSSRALCMYDDLSYASATLTRTMIDGLALNGNAPKVFTRVSTWGLPYVAVATNAAFGLLAYMAATTNAGNVFTWSVTPLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQF0</accession>
    <name>A0A2R6NQF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000957">
        <property type="protein sequence ID" value="PSR74775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQF0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="11059" checksum="2CC0B44DEEF0EA6F" modified="2018-06-20" version="1">MASVEDSSEDVSGDKSVRMNRTRGKRRGMLSRRVCTLQYGVLTYAVFIFWTHPRPTILSSTAESEYSMAPSQTYSRVQSLYPNDLQGYVIGAKTWIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQF3</accession>
    <name>A0A2R6NQF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQF3"/>
    <dbReference type="STRING" id="98765.A0A2R6NQF3"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="153"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="275" mass="30773" checksum="548B91E7886E5810" modified="2018-06-20" version="1">MLLTYAPPLKRWLRSTNDEDQTDEAFEPSYAEPTYYAIQSSDEESLDQTIQLSNQELAEELKVIELKIRSIEDQIRECQEIRATLLSDKTDVLRKLEATHRPAPTLVPNKGKQRDNGTRVDYNGDFDWTLALRTNLKKIFNIEDFRLCQKGVCNANMDGRDIVCLMPTGGGKSLTYQLPAVMAKGCTLVVSPLIALMADQVHHMEQAGVEAVMLTHGLSAVGKRDVRQRLVGMAEDSGTSRRDVKLCYVTPEKIANSKDFLPVLQDLDKCGKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQG3</accession>
    <name>A0A2R6NQG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQG3"/>
    <dbReference type="STRING" id="98765.A0A2R6NQG3"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF5">
        <property type="entry name" value="RESPONSE PROTEIN RDS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015321621" evidence="1">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="33386" checksum="4572E9DECC058226" modified="2018-06-20" version="1">MFTPSFILIALCSRLASAAPYVSKTLHSSDTSSWTSLTNSTTVNDTQIAQFALSLEYLESAFYSQGLSQFNDSDFQNSGFDPSVRERFVQIAEHEATHVVLLKSVLGSDAPQPCNYTFPFTDPASFASISFALESAGESAYLGAVSLIQNKSILTTAGSILAVEARQASYVGSSVLNNTPFNGPFDTPLNASAVWSLAFTPLPVLTLSPANATVNQSVAVAVSNNQDFSPSNIPIVNSTFVAPTTNGSTPLFLAFYHGLQVTFAPLDGSNSTTVPDGLAGVVYAALVSSNNTAPTPETTLSGLSVLNIPVPATANSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQH6</accession>
    <name>A0A2R6NQH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQH6"/>
    <dbReference type="STRING" id="98765.A0A2R6NQH6"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.50:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="370" mass="41430" checksum="6BF0C1366D746C82" modified="2018-06-20" version="1">MEALFYNVDSGFLEGIVRGYKAGLLTQNQYNNLTQCETIEDFRTQLASTDYGNFLANEPLPISTSTIADKATQGLVDQFNFLRSNAVEPLSKFLDYITYGYMIDNVILLITGTLHERDTHELLERCHPLGVFDSMPALCVASNVEELYHTVLVETPLAPFFRESLSAAELDDLNIEIIRNTLYKSYLEDFYAFCLSIGGATAELMSGILAFEADRRSINITMNSFGTELSKEQRARLFPSIGRLFPEGNNALARSDDVEQVRIACEGVSEYRVFFEANSGGGGSGAGAANGSTAHLLGDLEDAGVGAELEDRFFFYEVHLNKQAFLQQFQYAVYYAFIKLKEQEIRSLTWIAECIAQDARDRIHDFIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQL4</accession>
    <name>A0A2R6NQL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000955">
        <property type="protein sequence ID" value="PSR74848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQL4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8078" checksum="19867A0FAAF8E74C" modified="2018-06-20" version="1">MLLCLPTPANADWQARQAEAGRAKQPPRRGAREKLLPCPASPRYRLASLTLRIGGGGSEGSQRLGVGRAGVRWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQT7</accession>
    <name>A0A2R6NQT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v9454</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQT7"/>
    <dbReference type="STRING" id="98765.A0A2R6NQT7"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSR74920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="691" mass="76624" checksum="B4C260B893F89200" modified="2018-06-20" version="1">MANLAAERFLADRNAPVCSLNVAKSFGQLSSKEKKYAHYIAQASWAGARIIQGQLTPQAQKLYDLLILTFSNQGKLADLSTLKTKSGVSGEEWHGLLQYTSQVLSNLSNYKSFGFTKIVPRCPEAAFAAVVQNSPNTEAATALWNELKGHIYQVVPESSNFIGKRHVGEVSNYYLGEPVTDEEVAAIQAAAEKIGVDVLNTRVKKDSQTEFTLLVASVNVESSAVHDIEILDKQAKLTVQYGDFTENLTKTVAALVEAKKYAANEHEVAMLEGYIKSFETGSIPAHKKASEHWVKDVGPVVETYIGFVETYVDPYGGRAEWEGFTAIVDKALSAKYETLVNNAPELIKVLPWGKDFEVDVFRKPDFTALEVVSFATGGIPAGINNYYEIRESVGFKNVSLANVLAAKAPNEELTFIHPDDAELYNAWDSRAFELQVANHELLGHGSGKLFQEDINGNKNFDPEKIINPLTGKPITSWYKPGQTPDSILGEVSSSMEECRAETVALYLVSNAEILKIFNYVHKEDIEDIQYISFLLMARAGLRALEFYDPAKKKHGQAHMQARLGITQHLIKSGIARLEEIRSADGTLENAYVRIDREKVLSQGRDAAGKLLIDLQVRKSTADGAGARKFYTELTTPFPGWDGEIRDLVLRKKQPRKLFCQPNTFVVNGEVELKEYPLTPEGVIESFIERNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR09</accession>
    <name>A0A2R6NR09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR09"/>
    <dbReference type="STRING" id="98765.A0A2R6NR09"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="229"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="525" mass="59413" checksum="2F960B1151FE7C33" modified="2018-06-20" version="1">MAPQRDSDEPYIVITCEEAFAQEGRTASGDPLADPWAERASSTWVDPRTFGTRKLKELYPNHSVVAFANADVLSFPAAYVQPIHAPDMVSTVYFMPLARQMGRSTGMLLNSLRFGSFKVAWDKYDFILYVVKFLYGTFDNTEMYLLHEGPEEPSRALVMASGVWQNDLHEEIYVFDSGYWDKNHKLWVEVQKADWNDVILKDEFKVNLKKDVFGFFDSENMYKKLAIPWKRGIIMYGPPGNGKTISMKAIMKGCDAKGFYPLYVKSFRSWKGEEGAMVDVFEKARQLAPCVLILEDLDSLINDNNRSFFLNQLDGIESNDGLLVIGTTNHLDHIDPALSNRPSRFDRKYEFDDPDEEERKLYVQYWQGKLKNNKDISFPDSLANEIVDSTAKFSFAYLKEVFVSTLVLMAGFEEGDDKRDFADVIKGQIKALRKQLSAEPAGHTLHTTQRGVRAAVSPPDRSGQPDSRLANQGRIWEAGETFDRPRGSMLGGLPVPGMSRGNPDRRIDLRAIAVAAANSGRSYMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR19</accession>
    <name>A0A2R6NR19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR19"/>
    <dbReference type="STRING" id="98765.A0A2R6NR19"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="239" mass="26200" checksum="EED79B5B1949B659" modified="2018-06-20" version="1">MSTPAAPARAANAPQVAGEDEGSSYKTFIGVAKQMFIGWIIMQVVTRFFASKTTPTAPPPVSPPSVSGDGSQSTGASAANAPIPLTQAYPAWPLGIPLAMHVYLTTSPYPDVFSRKYDESLPHFVWDNITFGDWSDTRIVEYEVNLPESVQHNGSMWADIFLVKDGANPDPSSPQFDLSSVHHGRKLLTRYLPKSKVRKEKSLIGSHESEVDKEAEEEVRVITCTLVFLADPTYSLKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS94</accession>
    <name>A0A2R6NS94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS94"/>
    <dbReference type="STRING" id="98765.A0A2R6NS94"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="569" mass="63244" checksum="E60960B7631A9144" modified="2018-06-20" version="1">MDLSSTFSRFIFRIPSLFFLLRSLILWTFILVHTAGIFLQWSDSVLGQWAAQKSMEDICWSTFLSVCLALFVGSLTSGMEGWNPASNAPFNLFGYAFVLYIYASPITHVHKGKGIASRPDIHVLITMILPLLQLAMTHCLEVRQRWARQRLIPTTICGVLSLIHFHCVFWLFPTSYPLPNIVPNVIESFLLLVTLTTCALNAVTQVLLTGALTKPLFGHSAALLPKWEEDYSVVLFRLGTASLEATSVAGYGNEAGGIARSSLDIRGVRPDKNTVEISRSGMVTMTLGTDDTGRHRKLKIGFANEIKNVRAGTRQTEVWADTLVNVAWYRALGRFVEGMWRFASGSFRMLSAFVRRKPNLQKFAGEQLDIPNLHAIGEVEADDVDEDPDVYERFLRGEELSEDDEDFELSSQHDLDSPENMSPSISDAEEDSDGAVGEINGSEAITLYADLSQAGSTSTSAPLLLAHMTDTSSSPLTRRRYASLVLRSGSAPTTSSGLDSSDWGLFVRQRQEAKRKENGGRDEDRLLIYLAYITKKALGLCERIHIELVQSHAYLVPHPNFGTSLPWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSE8</accession>
    <name>A0A2R6NSE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000875">
        <property type="protein sequence ID" value="PSR75819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSE8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="9042" checksum="22CCAA59C60910B2" modified="2018-06-20" version="1" fragment="single">MADDGRGFLELLKPLMLQDLTNISTSIEPIDIPHLAIDEMLTLSEEDMENPFFKLSVRRIRVKRVIFLTSVVQATLHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSP9</accession>
    <name>A0A2R6NSP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSP9"/>
    <dbReference type="STRING" id="98765.A0A2R6NSP9"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21182">
        <property type="entry name" value="Tudor_SMN_SPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="74"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="243" mass="26024" checksum="0BDA343DFE76D737" modified="2018-06-20" version="1">MEKADLETYQVQLSQVELALSTDPLNAELSSLKSELQELIELTKAAIAQQEAAASSSKSEGSRKANGAAASSKSFVAGDDCLAKFSGDGQWYPARVASVGGASENRQYSVVFKGYNTTELVNASQIKALPSGYASPAPSSGVNKRKLTKAEEEEREKKKKKNEKKLEVKAAKAKEQTEKQVTWQKFAKKSEKKGIHIAGVAGTSIFKTPENPLGRVGVTGSGKGMTEVKLQGKHKFDPTADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSR7</accession>
    <name>A0A2R6NSR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000870">
        <property type="protein sequence ID" value="PSR75976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSR7"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11725" checksum="851E2ADD993E4157" modified="2018-06-20" version="1">MHANNSPRKKALLVGMRYADNDRMTSDSELICCTLEEFRDRLIRQYGYSDEDIKIPELTGSTSTNMSREFILRAAMDTLVTGAGVGDRFIFYCECNSGLSRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT95</accession>
    <name>A0A2R6NT95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000851">
        <property type="protein sequence ID" value="PSR76265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT95"/>
    <dbReference type="STRING" id="98765.A0A2R6NT95"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="488" mass="54145" checksum="F4E8A2057D584E92" modified="2018-06-20" version="1">MSSSYPTITSRPFVPHVITTCAKCHIQLEFSVPDSTPRSGTLLNIRCFQCQTVFTHTFYPTQVPGGFPSRPSAIGGSSSPPQDNTNARKGRKIGTDARPLETGYYDLLGVPVDATADDVKKAYRRLAIKFHPDKNRDDPNAEERFKEIAIAYQTLSDPTLRKKYNEFGSKESAPEGGFVDPEEVFGAIFGGERFVPIIGHISLAKDMKAALQEAEEGEDEEGKPVLRDAKGREIVSPEEKSKREEKARKVAAEKAAARAERVQELVGNLERKLGIFAESASSPTDPDVTQSYRTICSLDAEELKKESYGVELLQAIGFVYVSRAKQFLASNQTLFGVGGWLHNVQGKYHVFSETVSTLRSAIELKNVFEQIQAAERAGNLSPEEKKKLEEQAAEKGLQALFKGTKLEVESVLRETCDRVLEDPSLSRSKAQLRAVALQILGEAYMAVKKEDEQEITNVESEYVKVETKGSRQRDSQRGPYSPTFHRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTH2</accession>
    <name>A0A2R6NTH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000848">
        <property type="protein sequence ID" value="PSR76369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTH2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8267" checksum="63C8544E798956C1" modified="2018-06-20" version="1">MVLSLLPPAHLISIRLPHQVDEAVHCHPSLAVVPPALNIPSQYQYTVTNHTGIIITHQENGNNQENYKSGHGQVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU02</accession>
    <name>A0A2R6NU02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU02"/>
    <dbReference type="STRING" id="98765.A0A2R6NU02"/>
    <dbReference type="OrthoDB" id="2692881at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="23060" checksum="CF9027A306B6CE43" modified="2018-06-20" version="1">MAGQVLARLEAHDNRPSDAEIVLHARYDAKEAIWTRGYYLASPSLRCIFWLEMVFVNKVTYAVRAAMSEAHLGISVPFSRHIWMYPCHRKLAEKDLDELRDIVTYGHTGYEMFLHYHGEPAVRGSRTESALPEKGRLRVHTYLFKVFSWIFFGMPTLYLKELRKVWVDETVHYYGWRKFTDALKRDWENSITPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUX7</accession>
    <name>A0A2R6NUX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000804">
        <property type="protein sequence ID" value="PSR77257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUX7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="20965" checksum="C9ABDB975736789F" modified="2018-06-20" version="1">MFVATTKFALIIKSSMMNDISLPPTAEYLRNYFKMLAMALFEGYQALERHESRMSKEAIMFTGLPPSKTFDTMDGIIIRDHIKAALAFTKVLQTGRTQTASPKIGKGAPQVPAPKKSPRPSKVAAVTRSKANATKKISTARQANTARKSQRASSPKRSSPPRVIRSSKKALPVANNVAVATTRGTRSMTKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVD2</accession>
    <name>A0A2R6NVD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVD2"/>
    <dbReference type="OrthoDB" id="2758168at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="181" mass="20832" checksum="7E8302ED3144A89F" modified="2018-06-20" version="1">MTEYHALLSDGLISEDTLSICKTAIDAHKTRRFNATSRVLFAFGQPFYIRFGRFSKFYVIDTSGYQERIIDVLWVYPFNENGPLYRSGSAICCFELSNLPEHEGTRSVVIRVLKILEPITQTPQDDPRIHLPEVVEGGLLKGWLNKVTRYKIRKDEKLTGDQRRGLRYLKEYPEAIVSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVF0</accession>
    <name>A0A2R6NVF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVF0"/>
    <dbReference type="STRING" id="98765.A0A2R6NVF0"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="932"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1219" mass="134069" checksum="2EA391523CB4E487" modified="2018-06-20" version="1">MSTVKSSLWKTTTSKLCKSNMRSVDKRDRAIKRPNNSDESQASQLLKELARTPVRIFTNTTPSQHEDYLQEHGSLNASDRSIQKYSYHGLAHSPAKKGDNITQSGSQKENSLSGSWDPPGLQFNPSVTPQLSQRQKTPEEPVGSEARVENELSHRSRAGTQDSDESASVYEPRRFIIPVIPPKRPIPTKSASISNALASSSGTGTLKSLPARSKSERTRRQRSPSPQSQDSFAGPISFEAQQKLDPVFHRPLFELGQSQSQTSSMATDGTHPSAYDDEVPERFQNRVFVAGTPSISDQSQNQSQSHSTQDFSLSQPIELSQSQISYTTGQDQSADLGLEGDNSSIAFPVPSLPYPSSETSSYGPAIKDDDDSDDSQPVCIPTQIPGYYIPTQPSDVPSTGLSVGLPYATDYSQPEPSSSTTNNPRSILSMGDSHNQWRMHGQLAAQPTLPDDSMDTQVDNDFTQTQPSAASNLRATGLPINERPLSPPPPIARQQRHAPLRTRTVGSDLDIVPDSENADDAEQGPPSSPETISIPLGPPTPVKKAKDHVRTPVARIASPEIVPDSFIEEEEEEEEEEAPLAIATRKKTSLEVPKGRTRERSTISPVAQKKPSSRLDEPAPPRTRNQSRSATKPPGSATSRREEAMEVVPSSLPLQDYPEPAAKSRRPFKRKKPMKTRAAPVTPVQSHSSPLSESSDAESVVIPDYVPEEAPIEPTPTEVSLDADEEYEGPTNATASRKRKRIASPSKTKLNLRSASKVSKTPSITPDKRSAKRQKSTCSSRSLINAPTRVFAVWKQDNHYYAGTVHSSCDSGRFKIHFDDETEDDVHINYMRRCELNEGDHVISNITKGKGKVVDGSRCAPDNVVIVEFDNGEELDQQELDLRDIKIANRSITSQWKDRMLNADDIVTIVKPKGVKLSPSSSKLSLNSSASSTRKLFMKTGFVVTLSLQDENPDKKRNQLTKDLKSTSGEAFDDWSNIFDMPGTYSLSGKRWEITKGEVTFDKGNDLQRVFLLSDDANQKPKFLIALALGIPCIRTEWLSDSIHSLDEKEWSSYLLPAGTSMKLGARVSQAVDLDWCNSPHHLTEIMENPVPAKVFSGKHILCLSPDYLPVKAKKVTSSNALPNIHPNILAQGDVSSTDKSAESSRQVPYIILAMGSSRVEAVAGPEHASLKIKDYDYVIVKEDDDVKKFSAKHRNANFVPFHWVKQCLIAGRLFPNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVK3</accession>
    <name>A0A2R6NVK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVK3"/>
    <dbReference type="STRING" id="98765.A0A2R6NVK3"/>
    <dbReference type="OrthoDB" id="3251482at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="15249" checksum="D8E3108DDB244F83" modified="2018-06-20" version="1">MALPVVNISIDYEAEKDKIGGFLSEFAGKDLENGLADLGLDDNQATTRTRGMKYMDQLHEKTVTELVSRIRYNTRRYVQLFSEVVDKLMPLPTKDISEHDEVIDVILHQRRERNERMEGMQEGFPDHLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVQ8</accession>
    <name>A0A2R6NVQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000781">
        <property type="protein sequence ID" value="PSR77712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVQ8"/>
    <dbReference type="OrthoDB" id="3058553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="44830" checksum="79E60F22E4592A80" modified="2018-06-20" version="1" fragment="single">MNPYLTVTARYIDGSVEHPDSWKLHSKVIGYTIIHGDHSGANIAAVILKVLDRYGPGEKRQGQCFEHIVHLAGKAFIEALGALKDDDEDEDEEWLDPLDLDEEEEVDEPVDFDPVDLLGKVLALINQVCTLPQACVYFATLCVEEGLAPLELIKWVQTQWGSIYYLLDCVKVNKAAVNKFTLLADHSPKVPNLWKKNDSDYVICRPEWEVLDLIHEVLEEVHEAHQSFSSEPFPTVWRTIPTLECLQQQWEIMADTPKFAPVHTAIKAGLAKLQKWYLAIGQTDIYYICLALDPGIKTEYTFQNWETKYNDSGMAAFKEAFNSYKADILEKDAPSVVPSNAASTYTKGYGSSWMCNSLQGCLNLEKTQKRNSHQELLDYLNDPLVQDVSDLVAWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVR0</accession>
    <name>A0A2R6NVR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000785">
        <property type="protein sequence ID" value="PSR77682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVR0"/>
    <dbReference type="STRING" id="98765.A0A2R6NVR0"/>
    <dbReference type="OrthoDB" id="2418900at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="856" mass="97395" checksum="D523113DA2590658" modified="2018-06-20" version="1">MDNRKASARTSSATKPIIPRVPPNCCTFCHKRLATPIGVKLHIQNTEACRLRWEVWIEQTQRTRTRASGPSTSLTASDDNNDTTVSLEMAMSVDNFFSPIEESPSRGATVEDEPDDEDIARFVRYYPSPVAQVLRRGESTFEEWRRVNEKDGRPRWAPFANEEEWKLAHWLLKNVGQNKIDEFLKLDIIKRCELSIRSKYTFFQCVDQLPEADPWIYDELTVTGDVIGEDGKPLSERLDLWRRDPVECIRELIGKPALRDSMGYAPEQVFADSNGTSRIYDEMWSGDWWWNVQGKLPAGATIAPVILASDKTKLSQFRGDQTAWPVYLSIGNIAKATRREVTSHATVLVGYIPVTKLSCFSEATRSLAGYRLFHQCMKNILDPLVEAGAVGVEMTCADGWVRRIFPIVAAYVADFPEQCLVANVRESFCPRGLIPSNQRGEPTGCLLRSVSKSLDLLDKHKCGENPPEFHERGMRPVYEPFWRELPHCDIFACLTPDIMHQLHKGVFKDHLVSWCTKLIGDDEMDRRFMAITDVPGLRYFKKGISHVTQWTNTERKEMQKVFVALLVGAVSAEVLAVVQATIDFIYIAQYQQQTTETLKALRTAYDMFHRHKDVFVDLGVREHFNIPKVHAMFHYFEAIEQKGALDGYNTELAERLHIDFAKEGYRAGNHRDYIAHMTTWLQRQEAADLRVAYLDWLRDEELKEAAHGTRAVAGDKEAAGPAGDESDVEEIIRGKCPSPRTPLIVLEQSHGASEFLPALKTFVRHHFPQAKSLPNHLTRYNVYKQLKIERPWNRFVSTLVSFDKIHATAPVPARGRSPAVLAHLHTALVIKDPMVYRAREKGSLDGKHTPKVIQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVU4</accession>
    <name>A0A2R6NVU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v7676</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000770">
        <property type="protein sequence ID" value="PSR77855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVU4"/>
    <dbReference type="STRING" id="98765.A0A2R6NVU4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR77855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33376" checksum="2710A0CD36708A66" modified="2018-06-20" version="1">MGVDVIGSRVDEMLKRLSNACLPGSYLVEYFPIILHLPDMLAKWKREGKEFFKKDTIMFEGLMDSVRMKLHAGETRACFATVLIEDEKKYDLGAQKEAWLAGTILYVMQSAPPLLFCSKLSNSLAISAAGAETVGGPNHQTITSTDGIVQTAATLTAFFLAAVLYPGAMHKAQIELDAVVGPDRVPRLEDRARLPYIEALVKEVLRWRPVTPMGLSRRADQDDWYNGYLIPKGTLVIWNTWNVSNQPGFRGMNRDPKYFPDYEEFRPERYLDDAGQLSEPIPDTHAQGHFTYGSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW29</accession>
    <name>A0A2R6NW29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000762">
        <property type="protein sequence ID" value="PSR78032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW29"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="442" mass="49349" checksum="9DA75DE77B6B9DC7" modified="2018-06-20" version="1">MRSESSLSSTSSEVDNESNSSQSSIKTSSSVRSLEGTAEAFQHVRLQSSQDLNRKLSRGVKIGNQTKAHVVTKLSLPSVGWSSESDSDIPQYIDPAVLWPEQVGKWRLTSADGDDEKPIERLEGYSDVEQQSSEDISDVSSDDGESELENSDVSSDASEEEQEVNDPSPTRSVVKKTLPRRAKRTRAESLEEDENSTEASSDEDRDEDYKDDDYGQSHADNKPLRRLRPLVRRAASHVSLSGDDGDDNESRRKRVRTSGRFKDPSSLDIDHSSDVDEPFQEAVKVDCSHCSSRNQHQVKIPRNAKTTVYNEIADDFRLVLDPIQCPIPGCNGTMIIPEKCPMQRHLKKCHGSSHPTLVAILLSKKNKKVRCPWVHTDGRLCRHMSGPNDIGRHIVSVHIKCISYHCPIHHKDVHGRDNSSFGRHLKNPEKGACVKNQGPRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWV1</accession>
    <name>A0A2R6NWV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWV1"/>
    <dbReference type="STRING" id="98765.A0A2R6NWV1"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="688" mass="76731" checksum="BC8E8377C04B2097" modified="2018-06-20" version="1">MPGPGKRKTGKSKKAGGSGAGRDLSNVDISTVLDSYIDEINGTEGWETVVRFLCRMFDLPDLETRSGLKKIHNNFPQIQKNLQAAYTKYEGNAKITGGIAGIWARMSIDVILRDRLFREGLISKMIPLLDVRSTRYVGLQALSTVTHHGGVEVRHEIAKYTSTLLRLMEEFPDDSAVNDLVIVTLAHAVGSVITDDNVQAHTIRELDMPTVLRLTMINIRKPDAPHYMLSHALQLLSCSTLRCYREVKAIPSLVKLLVACLRSADLTVRCSSLGGLVRLFHNECERDLHVKDPQKFMAAIQRGFPKNLSDLLMAHDPTKCDTYVILQTSADYQKAMMRCVQDHDLYALGKTLAELILKTEFAIAEGGFQAYNERTGQPEIMDVGLPFKMWSDSLPICAKAVRAKGTPKDLDMADILDIKFFIMRQRIPEAAGLAKRAIERSPQVAYFYYAISLAAELTQGLRAAKKGLKCKQITPFVRANLLWRCVCHAGDLGLTRLQMAAPGDTAYSEGIAFLVSALDDAKTFTSEIPPDSRHHINISNWLILLTIALRGSELSPDLRELDDAFKKLDIARQFYEFFGIRQYKTELRLTRELVVSQYSSAVQEWEPFVRRFDSMGSDPEKAQDQGASKAEDNLAAWLEGMHVDDGQGCHTKCSHPKLTTNSVELYRCSHCGNPSAILRKCGGCAKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX42</accession>
    <name>A0A2R6NX42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX42"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6510" checksum="D1646B2A8C02FC26" modified="2018-06-20" version="1">MDPNGFGSKQVHGPGPYVPHPRPYAHVIPAYARFLMITNHWQSYSTWQRSHGYVNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX48</accession>
    <name>A0A2R6NX48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX48"/>
    <dbReference type="STRING" id="98765.A0A2R6NX48"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40965" checksum="2D4FFA868E0129F7" modified="2018-06-20" version="1">MQRHGSRYPLVSELVFITNLVSNLAGSSAAIKKAELPSSMEFLKTGYTSTLGHDDLTAPGRLQLFDHGVSFALKYPHLKASTLLAGLQDRVVESAQWFANGYFGRAWGGLNATTLQTIPEDNVTISWITPMNTCKNWQYDYGNNATITWGNVYLPPIAKRLNKLLPGVKLSTDDVHGALYACAYDLAAHGVSPWCGVFTESEIEDFDYELDLLMDGAFGYNLPGSMGPILGSLFVDKLIERFTNKTGDSQSLYLEFGHDTTIDMALTALGLAKDSPKLSATGPVRLNRKWRTSHQVPFAAQMIWEKFSCIASFKGPQIRLLQNESPLALTSCKHMDNKLGSCSLDDFVSANSFSTRISWGDATWNTTCGNAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXQ3</accession>
    <name>A0A2R6NXQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000713">
        <property type="protein sequence ID" value="PSR78951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NXQ3"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR78951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8845" checksum="E3689CAE0ECBDEDB" modified="2018-06-20" version="1">MLARIAPASVRRLPCAAPVAVRFYSEQNSFNKKEKAHEDQFAREHEREQLKKLKEDLEKTKAKIAELEKQQPSGPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXX1</accession>
    <name>A0A2R6NXX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXX1"/>
    <dbReference type="STRING" id="98765.A0A2R6NXX1"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="251" mass="26882" checksum="FA0C6C3B452AF8E4" modified="2018-06-20" version="1">MDTPATPTSDSPSSISPSSTPTAGHATPPYANHMTTPVPGSLAYYVYSIGGAQSLAQLYLEAGLLYLEGTASSLLSSSYAGLSSLRTPTLSNSLQPHSRSIECSAATGNGSSGSDAWNRDRELARKYFDRARDLQPGLDVPLLPPQSDSTTSNSNELSPVLDEQEQQLKIPTIELPNMEELAEKQVRKRRKRGEDSLRGDTSASSAVEEKLDADGEDHTWYLYLPGLVGAGTALLVVGFLSFSSWRKGQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY63</accession>
    <name>A0A2R6NY63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000680">
        <property type="protein sequence ID" value="PSR79872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY63"/>
    <dbReference type="STRING" id="98765.A0A2R6NY63"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33507" checksum="0CC085E361255147" modified="2018-06-20" version="1">MAPPIGTILRQMFPSEPTWSTNHIPDLSSKVVLVTGGNTVYLGARSQSKAEQAIHDLQQETGKTAIFLQMDLADFDSVKRAAEDFKSRETELHILFLNAGVLGTPIEQVTAQGYDMQFGNNVLGHFLLLKLLYPVLAASTVPSSPSRIIWLASASQYFFQAPMKYDTFKDGPARIKLGIHQHYCQSKFANVLLSFHLARTCHQDNIVSILVDPGNIKSDLNRHTTSFLFKILQWILLFPAKYGPLTQLYAGTSPEAMEYNGKYLRPWARLGEPNSATKDVEEQEKLWAYCEEQVTPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ56</accession>
    <name>A0A2R6NZ56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000626">
        <property type="protein sequence ID" value="PSR81098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ56"/>
    <dbReference type="OrthoDB" id="2751407at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="511" mass="58300" checksum="9686E6BF27985C00" modified="2018-06-20" version="1" fragment="single">GMKDQGSLECGQTRTPQVLTEESIPATMLLNFDVLFDVMLHVSSRRDASWLMQTCRTLYSVGAPTMLSFPVELRSKRHFISFHAFMSVGGGRRYQYLRKLTLGNGICGLTEEQMQQLIGLIHHATVIESLTIGHTSLLEEDLHFGYAIAQLTNVKEFFMDTVNKSKTPTSWELLLHIRSNVVSARLDLLLELDGIRQTRGDPIYLLQNLADSLEILDVRNADFATANIKYPHLKHLSVGLWHVAPIAPLIRAYPNLRTLVIHNLSFDLAEAIRRANREFQLQRTWEALDYVETTINAAYNLAISCKIHFLNVEEVDTPEDVTMLGSVLADCRPSILSLSWDLLLEVKQFPCLAKNIPRELEHLVLRMDLSTHSPDKMGETLDIVWKSLKTSKISKLEISLNWSDWAIDSGAPMYSLWRGGEKPTPLKQYVQGLNVKTLARRIISTIRSVQYLCLRISYEGQDQESGGYWRTNRQGCCLAIDRLDEAVGKKVMFKKDRHFYMSRQYQSLMHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZJ8</accession>
    <name>A0A2R6NZJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PHLCEN_2v6386</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000620">
        <property type="protein sequence ID" value="PSR81378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NZJ8"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="513"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="753"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="904"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="940"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="956"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PSR81378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1327" mass="148976" checksum="05D3243BA4D51F5F" modified="2018-06-20" version="1">MTTIYPATRSHQPSSRLYDVPSLENDGANFQTWKYRILMILEMRDLMGYVDGTAVVPGPSLPLQQSEYLRNDKEARAQITLTLKDEPLNGVLHAKTAKEAWDKPNARYEGKGKQTIAFLIGDLFRGTQSDETSLEPQLNTMRQKGYILSSLGQSLDDSLIAVAMVISLPPFYSVLRTILMSTDDKLTTDSVINAILTEEKTRQDGGAAALLANAGSFKSKSKTRRDDKKKKRCDYCKKLGHVKDECRKLKSDQASKEDNGGKDKGALTAKVASMQSDDNEYIQLFTAQALSTRKEMSRKWLVDSGASAPMSSQRNWFSTYHPLATPKRVWLGDEHFINAVGIGQIHVDLDIGNGQVCKVVFQDVYYVPQLHGNLFSVSRLDNLGYACIFAKGACKIYDPTKKFVGQAHKSDGLYVLSSTPSQSIHAHIADLDNSASDDQDLVLTACIAATSKADVSTWHRRLGHLNIDGVLKMIRRKLVKGMKITNTLAKDATPCTPCLEGKLARSTIPKHSEVQNPRILHRVFSDVCGPLQTQTRSGHRYFITFIDGQSHYLVVNLMKTKDEALAHTKAFISRAEVETGERLNYFRSDGGGEYGSKEFQEYLRQKGVHHEKTNAYTPQENGVAERMNRTIVEMARSMLKDAGLPNSYWGDAVTYATHIINRIPTRALHNGLTPYEAYTGHKPTVAHLWIFGCKAHVHLPDKKRRKLDAKSLECTHIGYAENRKAYRLVHRSSSRYFESRDVVFDENSVLSRVQLSEDSETEDISNDGSSDEDSSDGDESNPELPGADLPAVHPRGPAPDARDQNTDDRQEDEPASPVPKRTPGASMRPDLQAEIQEQVDAPAADTMDAAQAPARRRRRRAAQTPPIPYPQPPLSPALRRSLRPRRAPVPDDDPRYSVTSYTRQPREPAPEKREERERKQEEQLQEQLEENEETLGEIPSSASVGANTGNTAGQSGDEHARKASLDEPPLTHKEAMARPDASQWKLAEIAEIEAFVKAKLFTEVNKPKGRRLVDCKWVYTIKRGPDGEVIKYKARLVARGFTQIEGVDYNETFAPVSKFTSIRSLLALAAVHNLEIHQMDVKSAFLNGDLNEEIYMQCPPGFKAKDGNVWKLNKSLYGLKQASREWYKRVCAEFKTMGFTRSDHDHAIFFKYEDGHLLIAAVYVDDMLLISDHMPAIQKLKSDLSTRFEMTDLGEAHWILNMEIVRDRPRHTLTLTQRQYTETILNRFGLADCRPLSTPMVPNEKLEKLSEPEDGIDVKLYQSMLGSLMYAMTGTRPDLAYTVGVLSQHSATPGNAHINAMKRVYRYLRGTSDYRIVYSSERHSDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0R8</accession>
    <name>A0A2R6P0R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000578">
        <property type="protein sequence ID" value="PSR82687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0R8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="11336" checksum="7EDF60DCBA104A4E" modified="2018-06-20" version="1">MMRGHRHKLEFSRAKEKLWQIMGEVSEYLFSVLLDSFMSNDDVFIACAEIRGLTRFTRRRYARFHTGRPDCAGQQNASSTRRKDFGRYIDWKLLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1D2</accession>
    <name>A0A2R6P1D2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000563">
        <property type="protein sequence ID" value="PSR83278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1D2"/>
    <dbReference type="STRING" id="98765.A0A2R6P1D2"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="137" mass="14964" checksum="F96E9EA11974C50D" modified="2018-06-20" version="1">MYVSEEDISEEIRAHLPGTEEIIVQYISGYLLNLDDAAEDEDVLQVARTILESAIPSSSRAVSRADASLEKVITKLGEMLEEPLRKRAETQRTGNVNGHGNGLIRLDKVMDMSKTAAMSNTVAFGEGVDLESINKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P283</accession>
    <name>A0A2R6P283_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000541">
        <property type="protein sequence ID" value="PSR84138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P283"/>
    <dbReference type="OrthoDB" id="2802770at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR84138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31217" checksum="F49933DE00AA5CC9" modified="2018-06-20" version="1" fragment="single">MANVAPPIQDCIPQVVHPEDHNHGDPMDMRVHKDHKYLCMETAGSFVGPVLAKEFMKRFMNIPGRRRKIPRADFSDVLKGTSNTNMYESLISAIKKSKICPRMVFRRLSSITQDDIALRPDLAGFNANDGEPSDNAAVWSSMQLCIDNRAEDAFDVAYDPNDRESLRESEGGSTKPLGQMIHYVREQMSHQHRVFMFSLHTVHDSARLIRWDRMGAIVTEAFNFVLQPQILAEFLFRFSLLGPEGRGLDSSVELAGPQECHEFTEAVANYLDSFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2A2</accession>
    <name>A0A2R6P2A2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2A2"/>
    <dbReference type="STRING" id="98765.A0A2R6P2A2"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR84217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="242" mass="27164" checksum="EEEF98475673C2DE" modified="2018-06-20" version="1">MARATGSRSQKQLSQSQNARNAMQPSQSQRGTRRGHVQEEEEEEEEEDDEEGEQNGVDEGEGDGDGRGDDIDRKASDLVRLALFHEQRRIPLRRDEISKKVMGSKSRKFGEVFARAQEILRKTFGMELVELQTRVEEKDDEQKKDLEKLGIKKKTASTHTKTFILRSVLHPSLIEIAASPDDDILRVEQADHTEDDDDDEGSPRCTGALLAWQNSDQLGSVGVLYVILALILVNGKTMSDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2G5</accession>
    <name>A0A2R6P2G5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000533">
        <property type="protein sequence ID" value="PSR84468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2G5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR84468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31468" checksum="2330F2534D9FA109" modified="2018-06-20" version="1">MLQSLLSLLPNLRDLAFSEVTLGWAALSEPEDWLAFRPVRLDSLSMLNIMTVSQTPLEIVASLCLFSSIKVLHIEMFVNVEDFEGHYDDPHAQPTHPLLLSTDNPYFPSKLRVSSIEVPNPSHVPFFLALIAKTASVEAITDVDVARDTNEQIRALGSFLRVVGPRIKKITADIVALSYFTISAPTTVQKVILDIRIGGITRSWRDQDGSDYISVSTASEFTHFQSAIKQREGVRKLCIRWYHMPQEKPEAKLLKRMDSLVRRQLLELDAKGILSFEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5E7</accession>
    <name>A0A2R6P5E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000527">
        <property type="protein sequence ID" value="PSR85707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5E7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7656" checksum="57DDB50184337520" modified="2018-06-20" version="1">MLTHELPHIFPLASAQERGTIPQCESSKLDGRVDANKYTGPAADGEINTNEIRWHYQSILGRMSSTAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8H2</accession>
    <name>A0A2R6P8H2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000520">
        <property type="protein sequence ID" value="PSR87006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8H2"/>
    <dbReference type="STRING" id="98765.A0A2R6P8H2"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR87006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="693" mass="75746" checksum="123F6E4C4ADDCD51" modified="2018-06-20" version="1">MSSFFKSPNQFGEGTVEVNGPKEDGYTRIRRLAKTKDRLVTQPFEGIDTVYDVVAYAARTHGKRDAFGTREIIDTIEEEKEVTKVVGGKEVKEKKKWKYFQLSDYKYISYLDVQEAVSEIARAFIDLGITQDDIVNVYSATSANWQLVSFACCCISTPIATAYDSLGETGLQHSLNEPGCVAIYTNAELLPTVAKVTANVPTLRLVIYDGDASPGVVDKIRGARDGVRVVTIDELRAIGREKPKELWKSRLPTPQTTACIMYTSGTTGAPKGVVITHSNLIAALGAIYHLLGQHLKPTDAYLAYLPLAHILEFIVELALFFVGMPFGYGRVKTLTDQSVRNCLGDIRAFRPTVMVGVPAVWEMIRKGIISKLNSSGALKKNLFNGALAVKKAGIPGLTQIVDSTVMAQIKAATGGRLRLAMSGGAALSRETQEFLHLALVTMLQGYGMTESCGMCAVLPPELMQYGSVGLIMPSVEIKLKDVPETGYFSTNDPPQGEVLIRGGSVISGYYKRDDLNNDEQIFTKDGWLRTGDVGQFNADGTITLVDRIKNLVKLQGGEYIALERLESIYKACDLVSNICVHASPDAKQPIAIIIPHESHLRHALEANPIPGADSREELHVLCGNSKVSDYVMAQCNALGKKNGFKPMEILEAVILSAEDWTPQNGLVTAAQKVQRKRVAEAFDAQIKAIYKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8I3</accession>
    <name>A0A2R6P8I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000521">
        <property type="protein sequence ID" value="PSR86938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8I3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR86938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6562" checksum="54FEB970323C13AF" modified="2018-06-20" version="1">MQKRNVDVADTTHGKYIKESRYRVAGGKAVNNKYMRTIPLGNGEAMGVLWGVGMLFDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC05</accession>
    <name>A0A2R6PC05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC05"/>
    <dbReference type="STRING" id="98765.A0A2R6PC05"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="165" mass="18366" checksum="168D380E4CEF3945" modified="2018-06-20" version="1">MASATQPSADAESIIESAHEIRITSHGKYNTWVDFALRHFESNEDRPLTLHTLPLQVPKSSEPHRTGLDEGGSDIQVVGSHGGKRDRMHPSLSLIPRLISVVEIIKREYVKKLDPLLAEKGCLSGLHQYNELGTLDSFGEETEDDQVREERRLESLASALKGTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG78</accession>
    <name>A0A2R6PG78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG78"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="6829" checksum="BC833FC4F5A492D1" modified="2018-06-20" version="1">MLRPSPMSKLSLTPGRTSGGVYTLGSGLSRRPDVKRTSNSGGRNLEDDHELKHGLVDHTLDGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGA6</accession>
    <name>A0A2R6PGA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGA6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="797" mass="85926" checksum="16AEC5E9CC28E906" modified="2018-06-20" version="1">MPKALSDELLKKLPLKSILKNREPGPISPEYYAKHHPTSSVPTSEAETSKRRIPGAINSRENRIAINDIRDSRPPRNDELIDVESRSKWVRYRGSSSRRKEHRHTQETQDSSSGTPKRRTKRRSAPYSADPSTSTLRRTTRSQTAALKTQSSNRARTASGIRTTRDTSSVDDLVAGLGAVAINGQSLDNSTPSSNPSTTANPSATRKPLVKPTEDDEATKLAPIRIDRTSMSKDVITERSRLPPSREVSATKDPRPRPSSPSREASPVVASDRTNSAEVESDSAREVQPSPIASTSHGIAKLVTTERVRPLTPPPHADLEGKTSAMMVDASDPFEMQTSPTVFLPVQDPLKSPLIRSAVAAPIQLPSLTVPIPLSQAAFPSAPLDSEPHSAPQKSSSSSASSFLPHAAAGSWTSFSEGKEESVVISDNGGSSVFTPPTTSGRPAANYHSSWNLSSNDLPALAVEPTLSISEISLEGWFARPAPEVNLAPPPPAPSVQPTTSGFSWLDYAESLRVEPVRLQASSWIAPPSVESWIPIDAPPSDLDSPNSSSDDFYKMLRSYGSRKAHTTDHSTASSTSLHCGDLYTSIECCNDGRIPSSGVVQTPRATCAPYSREATLKMFSKSMTAEDDASSRYIKTIVDDPILLRLAGLEPLSLSTALSSSRTSAYCEAPSYDYIPSSVGRRTSSINTTWYPPIPTSTPAAAQELSHENPVWRDLEPSPTIQLPDDDEDPLVAQDSSSSSSDYLFDDDEMFAIFESFTVAPEEISNDHHRMGWGNTASTVGSVCGRAVGAIISYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PK05</accession>
    <name>A0A2R6PK05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PK05"/>
    <dbReference type="STRING" id="98765.A0A2R6PK05"/>
    <dbReference type="OrthoDB" id="3254002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR92221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1086" mass="118084" checksum="5D8FAEF5AF3D041D" modified="2018-06-20" version="1">MTRRPDSPHHDISRAKVTYSSQASTTAQAPPAYIPGASSKDNQAVLQAITRDIFKVMKRLQPTIINAVNRHVVHQLKEKLDPRKMIQLPIGFDAAATTEIHEISSYIVNKVQDLTAEEILQILRFVSGKLAAQSGPSSTSQPIAPSSTDSPSSLPSTSPPDAIPLVASTDRPLPSIADGVGQKPPPNQTSITQPSPTGFPPEQVFQGQSQGGGSMAGSWVTDTHSSWKGESSPKDQYSTADIYSEAHLDLQGQPSENQRFTSNAEVSVSLPPLSNGYHSPHRFQEFTPYRIPPVYAPLPPQPITQTKTERRQNDGVAAPLRESEESHTPVTPDMRMHVGLNKSTIARDILRSLGRPSSSSGSGRSSPVPASLQLKRKAGADSDDLSHKRLKQESMVDSEAAESRSTEGEPGDNEVLKAASEDLEEIKTYGALEMEQQQAEDEQMDRLRGVFDSVEQLQIQFAQTPAGDGVHSHTETMSFSQGESSSLPSDVPESIDMKDDAPFRHPPPPVPDVLPIPVDDVERLNVLSASSPPPSPPALMTADVVGSQIPEPLPPTELLNDSTNHASTSQVESSKVERVAGSAAREPLFLPSPPASTSDREELIDEDIDMDSFIPSGLLGSRIPSPKKDKGKQRAIEEDFEVNEPQPIKERWRKRNRVVESDSDVEAEEILDSKEGRIPRRRVYVLVPPLPRAARRLNEKLRRTEAQRRVATHKVDQRRANQQEAAQRALAQQIVAAHTNDNANDVPASPSVVEAMDQQKRKEGVTRSQHLHQACNKSYETPVELARHHAGHQGEQLKPIAGAEPLRSTSSIPPLPEFLPSYMSVPRRVTKHRMSHDIHIWLGAKASNINICWFDINAAVPSRSTRHLADVLNNVEREARENGFGPTKAVLAFSGDEYDSWISYSDNLGPKYCDDVFSTAVTQMVGKGLILGAPQPSASTTGQSGGSEEATQTQGIPIIEADGVNDVPQCDIQDVQSLDTSFDALEIQSVIGSEDLTEIAKRLVDGPSVDNPLQQEMSAHQEMPSTTNSNLEALPAVHEEQLLAPTGEQPELLPVSKSGAATEALGPTAQPEWTVLADEDTVDSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMZ8</accession>
    <name>A0A2R6PMZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMZ8"/>
    <dbReference type="STRING" id="98765.A0A2R6PMZ8"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015321624" evidence="1">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10744" checksum="81A1B1BBFDD64A9D" modified="2018-06-20" version="1">MLVVFFIPLVLISIYEAELDPAKNVWVKEWLSHPDQGLDDTPEYRDPVVDGPDAERGFKISVTSYDDLVKVFPDTTHVSPFDMCVRAAERTDGCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN83</accession>
    <name>A0A2R6PN83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v4485</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <sequence length="1365" mass="151540" checksum="6C132402BED8A639" modified="2018-06-20" version="1">MSEIRETLVQERVAQLSQVRRRRNELLRELYFLRKGQDDLLSIEENEDGLRLFLTQSDLVNKPELSHVTTFLDSENTLPSPASSPSPSTPGEERASVSPDAAPLDSPMSDPPASPGIAEHGDAHLDLLYPDASSDRMEVDEALAIDEKEEDLKEGDLEEEYPEEEDIEEEDLEEEGAPFEVAEEVFPDASGSNRSHSRVPSEPRADEDQRSARSRASSARRSVVPILDPTRPPSMEASHSPVPLQEEEHEDAELSQDSMRVEEEHMEHMLETTLEEEPSRREEPSRRPTSEDIFMDLIHTSSYNEPPLPTAWAESQQSVSEYVLDATPPPDPPQPDFTFTEEILPPPPAEPPKPTVAPLDLLYTAPVYTLPSFSALPAEYIRKGRPKQSRKREKEKGDGKAQEWTPLGLNKWGAVIRANPVHTKLSKATKCVNTRDWMVGMTELKFLKAIDRVELMKDAGQWSFRQPKKQRGVGGLTKTHWDYLMDEMKWMRIDFREERKWKLALAYNLAHAVVEWHEAGSHEERAKRGICLNWRKPRPEEIEDNQGILMDENFGPRDMDEDVAGEESKGNSTPANDDNSEDDSEDDQEKEEKDRQDVIDALEPTSTLQDALDDAEVIVNSASTQDQSGHYPIRPKVEDIEDTSALRSSRGAGAMDIDHPAAVGTSEINANLDTSLPKAEDDIKLGLKNSSLNPILASQSTSEGPTPVQRSKSKTNIYAPLREQIVYSELDKLILDLDDFDLAKCMSELSTDEHSHSMPSFPADLSDIFPDLHPLGLLDVAPNPGSEGKKKSDRRGDKDDPNKRAEDTTYQKLVPMSDFMRSKTTLLGPLQPARHWLQGEWHDLDETAVAADHDSPSSRSMDDNVNCALFDGTKPYSPAATSSLLPIGALRRRTPYELFLESGRNASGSSHHRPKLNDTAWTPQDDAILKQFVEKYPNNWTLIAEAFNSSRVTVSNDRRSPVDCFERWKSRLSANQDDDHRPPPQTPTTQMTTRGTKRSLSTSVSMSNGNANNAGNYQGGEPKKRRRHNLMYDAIRKAAKKREATQKATAANQRKPAAMHDTHGQYNKMPKLSPQELSRMKAEKDARETSERRRNEEQIARQHQMQQAQRAQAGGTPVAQATVQNGALRPPAAGIPVAQGVPQIRQQPQVNISQQQQRISGQMGLAANRAMANAQAQHRQGTAQEVQMRQLAAQALLEGRSHPAATSLAAGAAPALTAHLSPPYNAQRATSSSPGLPQQSPPLAQAIAQNMATSPRPPSAQALMTPTPGAGASRPTPALASYYGMNGVPNGMPTSVGAPGPTQQLSTDQITHAERIRAMLLQHTAATAVAMQQQQQQQQQQQLLQQQHQHQQHQQQQNNGSYSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN84</accession>
    <name>A0A2R6PN84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v4494</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="98765.A0A2R6PN84"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation initiation factor IF-2"/>
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    </dbReference>
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        <property type="entry name" value="Translation initiation factor IF-2"/>
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    </dbReference>
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        <property type="entry name" value="Translation initiation factor IF-2"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
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        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
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        <property type="entry name" value="TIF_IF2_dom3_sf"/>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-G_D2"/>
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        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELONGATNFCT"/>
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        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="368"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="258"/>
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        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
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        <location>
            <begin position="92"/>
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        </location>
    </feature>
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        <location>
            <begin position="124"/>
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        <location>
            <begin position="263"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR94066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="899" mass="97383" checksum="08FAA39439D77B30" modified="2018-06-20" version="1">MHYTRRAICVERSGSRFVATAAKPAPPRPISKWALPDIAAPYSPDTRDHDGPPHASTSSASGKWSQSPPTQTGPYSSSVRATPLWPRPANKSAPNPTSTYLSKWNRPGTSVQGAIPERAPINRSRFERDDRPQMRIPGSQTRAPKVSGSFGLRPPGPAPSSNPRSQTSRGPWPSTRNTLDFAFDSPPKKKVEVQDRDREEVSQHSKQQDGAVSRISVDAEEYADSERSAKNPRYGRTKGSFKERGSIANRMSENVAIPKHSRVKADPRKMKEVKTQRRKYVQATRDVYIPNAVSVGNLAKLLNVRLDTLQRKMVRAGMNDEASYDHILTAEWASLIAMEFGINPVVDDEAAFDIYPPAPAADTSTLPARPPVVTIMGHVDHGKTTLLDTLRSASVAKGEAGGITQHIGAFSVPVPGPEDDPKSERFITFLDTPGHAAFSAMRARGAGVTDIIVLVVAADDGIMPQTREVLELVKKEPDVGLVVAINKIDRVGADISKVENALFAEGVQLESFGGDIPSVHVSGLTGQGLPQLVETISLIAELQDLRAERTGMVQGYVIESKIQKGLGAVATVLVSRGELTPGTHLIAGTAPGKVRLLTSPSGGPVKSVSPGTAAVVSGWKELPKAGDEVLSGSESDIKRAVTNRLRKIEIETSLQDVEAINLVRREERERKEAEEEKDGEETEKTVEKKDEKKELRIIIKGDVSGSVEAVSGALVGIGNHLAGVKIVAAGVGDVSESDVMRAKAAEGMVVAFSVKVPRPIEAMAANQGIQFLKSSVIYHLMDQVKERVIGLLPIKIETKVTGEANVLQLFDIHLKRKQTMKVAGCRVIYGVVDKNKKARVIRNGETVHEGKLETLRQIKKDIMQAGKGMECGMAFDGWDDLRDGDLIQVYEEIEKPGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN86</accession>
    <name>A0A2R6PN86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000464">
        <property type="protein sequence ID" value="PSR93973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN86"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="356" mass="39035" checksum="B647BBB841566C93" modified="2018-06-20" version="1">MPTAQVNGNGAEIFYEDSGAPPGSTDYATIVIVHGLVFHSGTFKRTLPFAAPNNLRIVAINQRDYPGSTLYTASELDRITSSNVEDLELALQAQGQEFATFLVHLINAGGVLPVQEKDGKKSGGLAVLGWSLGNLVPLCMFGNAKHIEEETKSLLNEYLRTLVIFDSPPFPIGEPIPKEFSFPLWDSTIAPEDRGPCFAIWVGTYFSPAVPDLSSMDIQALESRTNISQTSEPDNMAPTTSRMSVEELQSMTHPEVLERSGGPLMELEPAVYWRVTERALFETEGAFASVDAVAIWCNMSVAPCVWAARRIAERAEAAKTEGKRGRKVDTVKIDGANHFPHWDEPERLVRLLADSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNH2</accession>
    <name>A0A2R6PNH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000453">
        <property type="protein sequence ID" value="PSR94364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNH2"/>
    <dbReference type="OrthoDB" id="2692137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="611" mass="70333" checksum="EA96CE1577536A31" modified="2018-06-20" version="1">MDDTPLDRPQKKRWNDVVHTVQSSDVLRYRDGLAGCATPDDKYLVTSPNVDWIPRPVYGIVSVSLRHDGRFGIHDPVLWPQVFVEQSRYAWLCTVMRKPSDVHDSRMPMWLNLSPVNFVPTGNCIVTSLGTLDYRTLDMLRPLVHAMQVRMTALEEQCGRQPELYYIVIAMQEAFDRLDYPSTFRDLLFQFSCVQRYWLLASAWFEWHVHVWRSIPFTEERPPPLSIRTDLMGAITTNPSVVQRLTSVGIPVWFMRLMDTVTQEDIVIDSVLFTEPVDIAEDSGLFGGSAIYTGPVDPPRNKAPKINPGERCKFHDFQSDYAPPSIPVWRDALARVDRARPAPDVADVWPYWFPEPALLVSPTKDDRLLRHFVNWHRARAPWIYVVTHHSMTDGVIRPLTPAQWREYLNTGEKSREDIKVKNTKKADQKRQVAAIFESIFGEGNVVEGQVPSEWFGRAVNLKEGKDRQLMLEMVWELCEMGFWHELLEVDRFLVPSMGRDPDTGEFQRRLMVNNVFPPSRPFHLKQLPTAIDGLAASDLMSRARYLDALRLLLSRWPSVPPSIKSSQSLLNVASVPLLEKVERDMAKFYCQTFYEVSGRAAIIPRRFPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNK6</accession>
    <name>A0A2R6PNK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000450">
        <property type="protein sequence ID" value="PSR94464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNK6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="251" mass="26851" checksum="12CEF3805B2AACB5" modified="2018-06-20" version="1">MPSASDGELSSFGNTPSSQSPASESASSEEVLDNVSIQFIVAKAFYVAAERGDISMAPSTPLVPNVRSLGEPAPSSLDEEASLGGDVLESNTSGLEPSTANECHASPLDNGVLQTNSLDECHISLVTEAQADFTETTQTGLRQPLETLEGSEHQSMEGITTENVDSDLTTTKAASKKQRKPGKKAAQTKKRSLPPHSKVLDTRKKIKDTLPSQETDVHAPEGSARGRRVSKPTAKTIDNKEYESVRFRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ45</accession>
    <name>A0A2R6PZ45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000420">
        <property type="protein sequence ID" value="PSR99333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ45"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR99333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5715" checksum="36CA445EA6AA69CC" modified="2018-06-20" version="1">MKDGNVTSRGTWWGSDSLMKLKDCCGPTTGRWDKFTSRGAPVNGPNQDQDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ78</accession>
    <name>A0A2R6PZ78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000419">
        <property type="protein sequence ID" value="PSR99441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ78"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ78"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="35264" checksum="9B4C208DAB284C14" modified="2018-06-20" version="1">MSSLFRLSTTGAASCRVHARRLLSTALSSSLNIEALNKWIASENKLTVPDTLRPEHLSSLYATLPTRDHAHSPPTEGAPLGYGHHLVFFHPRNPESVLRWDGTDADFCPPEPFTRRMWASGKMTWKATGRGALRIGDSAVAVSEMGQVKKKGFEEGGLPMVFVKQMIKYMKRGSGQVALEEERSHVYLAAPANQRPTRAVSGLPHPDFSLKYLPSATTLFRFSALTFNGHFIHLDKDYAQKSEGYPERLVHGPLTALMLLETSALQRPDAVFRTFEYRALNPLVVNRPVTIYGAWGKSEVQVWAEDGDGTVGMTGSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBI0</accession>
    <name>A0A2R6QBI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6QBI0"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="57"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="602"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="673"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1309"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1610"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1724"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="948"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1145"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1186"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1229"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1379"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1611"/>
            <end position="1629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS05492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1835" mass="189547" checksum="E8D0375930A88A52" modified="2018-06-20" version="1">MSVSQLQPATTSQVQRNSKEGEDKEADFLALRLLNKRARVRLSPNALKLGSLPGRGTLFATANSLGCFAAVTNNLADENNLIVSSLSELRSAFASTALDGEIPYDAQRVISLPTTPNALTFAFNNSRLLVGLTDGSIVVYDVQILLSERPNPVEPLYIFASPTSTAVRALAPNPADLANLVAVLYEASGNADSLSVQLLDVQKLEISGGWKSGSTPKTIPTSLSWSPKGKQLAIGLQSGEVVTFSPADTSKVKSLVPSPPSLQSFSAISTTWLSNTDFHCIYASPGSLTPESEQAHYILSLDSKANTATDVKLINPYLPYPGLRGPGAFTTVLRNWGPAKFLLFIGDSTSSDIGLIGCTTDASGQEVWTNFSLEETSTPTVPLDKDMNDTVLLGLDLDLTGTETYNHKTASGEDAVLPPPPVMYAYASDGTIVGWNLLNLLGSAYPNMVKPVAPIAQDSTSMTLEFMTDAQAVTSLPTQAPVFGNAPTPTFGQASTPPPFGQSAFSLPPSQTGFGQSAPFGGASPTSSSPFGSQAPGGSGAFASAGPSSFGQSSFGASSLVPPMTKTNSTSPALASPMAISMSNSEEPMSAVFESNSGFGGLSLGGGDQSTEIEKKPSSSGVFGSFASPSTNETKPGTGFGPTNAFGGSSSLVKPASGFGAFANQGTSAFGSTAFGSTSPPAPEDVNKPAPSPAFGSSGFTAASSPAFGQSGFGSKPAFGQSTFGQPAFGQSGLGSTTTKSPFGQPSPSGVSTGAFSAFAQSGTSTFGSALTQVSGFDKKESSSAIAEASKTPPGETTPAATDETLAIPSTPKPVSAFGSPATPSTSNVFGSTPNPSTTPSSSPFKSSILAPASGAFAGLTASPVGFGKLESGFGAFGNATSTSSPFFNPPKTPTTSAFSGPVSAFSASPSTIPAPSKPTFGSSSALGAAAKPSFGTPSALGAPTTVFGKSTLSSPTTPIKPVEPPTSGGFGAFAGSGGFGAFAGGSKSFGDLLRKETDAKELPREPPKAPISVFSRPSPMPLRQPSAASYSRTATTRATESEEGNDHGDGRDVAEDEDETVSFLSDTFSEDEDEDESGPEEGSEDEDDDDESDDNSQSSQPPNSTTPGIRLTSSSPPATSSSAQITTGEAEDATTPSGPPEKQSAVASPVPVNASPSSTSFTLGLGRPSTRPARSSPLANAPISGDDEDEEEGDATVKTKTSKLPEGASMNLPPTVSAQMPSSSLSPKPEESAEKSKSRPKTPPLLSTFTPIIPKPSPFTLAPPTRPSSEPTAKLGNIFDINLPTPSHAAKFDSVLSPPLALPNVFGKPVASSSQSPFSPPPGGFFGKKETPSPPGSFGQDPAPAATLLSPGGLLGKTTVNAGPKTPAQAAPVFGTKLPSSQIPTTAGSFGKAPAQPTPGRSASALQPLEEGMQRECMNLFRALAEELEGLKGLASQAREKRGENFKPLNISRTKADLTDPKKFGVGDAVEFGRIMRSVERDILELKDVRAAHVKKVGELEGAMLKATMRKEEIVRFSKAKKDAQFEKMLNSRTLGPEHLETQSQLRRSIRVIRDRILKLEDHLQTSKKRLNEMKLGKPGIRTYRNIDSAISQQAEEVARLAARMSKLNLKHETSTSRADSRDKRLPLDLRSSPSRRPLTVTPNVAVTTAAALNAERSARKLKGALLKIRKEPLLNTQAVDAPVPHTAFNGPNKPTSPVSPVNALKIDAPAWILNIPSNGELPETPKWSLPPFEIQESPGSPSPSPSHGGSLRQRGTGTTKMHSKPIALKKSPGIVASTGVTSPPAGFSWGPLPGVTPMNSLSSDVRKKEAGSSTTGALGLSASWVAEGFTAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBP4</accession>
    <name>A0A2R6QBP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000367">
        <property type="protein sequence ID" value="PSS05547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBP4"/>
    <dbReference type="STRING" id="98765.A0A2R6QBP4"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="226" mass="24979" checksum="6FD8DD2D8F812BA3" modified="2018-06-20" version="1">MQANVMPTSWVPSYSRLYPELTFAGLRYSSLSEDKTSPLHVVIGHTPAKVVRDALSAFMQRSNISIRGFTCDPDDAIAYRVRDIVQGWDLGPYLKTGIELAAAGYGHTPVDVQVHIALYTLVGLCVDDFIIDMHALQDDILSFYKEELAGEAKNFIHDRAVTTDTSASAAPTDTVDAIVGAVHAARSILKGQKDKETLQRWLVGFAAFHFQTARYRLKELTGSEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUI7</accession>
    <name>A0A2R6QUI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000308">
        <property type="protein sequence ID" value="PSS15414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUI7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS15414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7350" checksum="14CB4A6A9B1813C2" modified="2018-06-20" version="1">MILKQQEDTVLLGQKGSGMECQGCDQAQTVRPIGYHQGRRYCSRRGQTGRSRVDTPSVRGENIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3W9</accession>
    <name>A0A2R6R3W9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6R3W9"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS19943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1525" mass="158561" checksum="A52F102D9788DF8C" modified="2018-06-20" version="1">MKPASTTRKPYSGQTRSLVLALDIGTTFSGVSYAILEPGEVPQIHGVTRFPGQEHVAGNSKIPSIMYYDQRGDMKAAGAEADGSSVLAQAEDEGWIKTELFKLRLRPRSMALKMNGMRLSPLPRNKNAVDVFGDFLSYLFRCTHSFIVDTHANGHALWRAVENDIQFVLSHPNGWEGAQQTKMRRAAVYGGLIPDTDEGKARIRFVTEGEASLHACVLNGLAADVLSNPSGHGFIVADAGGGTLDISSYAIRGTSPLVIEEIAPPDCVFAGSVFVSRRARGFFEEKLKASKYGTNDSLDHIAKRFDETTKRLFRDDKELQFVPFGSPLDKDMSAGIRGGQLKLKGSEVAELFEPSIEAAMASIKSQIQASAGQVKSVWLVGGFAASPWLFSQLQDRLGQFGITVSRPDSQTSKAVADGAIGFYCDHHVSARMSKFMYGVEYLRTYDANDEEHVHRKHRLFEMPSGPKLLPDAFDCILARNVRVKESNVFSRKYCTEVTNLSTLSVFEVEIWCFRGGNDIPKWIARNHEHFSTLCYVRADLSPLAGSAQSKEGKGGKMYWNIVFSIEIHFGLTEFKARIKWIDNGHTNGPASIVYNESGHRAAEEEGDLSPDEEAAVASPTPSARHRSAAPSRTPSVPSTPAHDSVSLKSRGASRVPSVAASPHPSQVDLHAPSRAPSDVGRPHERYRTASQSSRAAEPERRSSGYTSRPPETVRDSRRSSVLVDKDIERSMGAETPRAPDRMADQDRSINVSAQSTDSRISTATARLGETLSSIWGVPSSQLQTPAASPRGEAASYFGSAPKETDELEYLTPQAAASKAPTPPAVSKPATPAVVSKSLSPVPGSKAPTPPTMSKAHTPAASGAATPQPTAPQPAASVSATPKAASKVATPQAVSKAATPVATPKVVTPVISKAPSPVATPKVSTPGATTPKPPTPPAANAPLEAVASKAPSPRGSPKLSTPTIEVSTPVADATPKASTPTATKPPSPVTSKAPSRAASKAASKAASKAASAAASKAPSKAPSAAPSKAPSKAPTPKVASPKEEPQVLSEPPSEPAPAAADSSAKNDDDDAVIPPKPAEIAPPGSFPAEEKKPETPPALGLPSSIFGDLSTNPVDSAVADLWSTDNKADADAGGFGNFLSTGSQWGASAIAASKVPTPKRQSGFGSAAAAGNGSSWGGFGSGLTSTLGTGLSSTLGWGSKATGNSPGGWGIGSIGSALGKGSPEALNADASKKAEEAKKKAEAEAKQKAEAEEADAAKKAAEEAKRKTEQEAVKKAAEEEAKKKADKEAEEAAAAKKAEEDAAAAAAAAKKAEDDAAAAAAAKKAEDDAAAAAAAAKNAEDEAAAIEAAKKAEDDAAAAATKKAEEDETAKEKREEEPATKTEEEAENLQVQAEEVGGTPEAAAAPAVGTNDDEPTTGGDAAKEDEVGEGGETKPATSDEQLAKDLEDMLDADPNKGQEDKDDDDDAWLGGKKKKGKKGGNNSGTATAAAAAEVMSRTTSAMSAGGAGSGGGNAASKQKKKKKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7E5</accession>
    <name>A0A2R6R7E5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v3036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7E5"/>
    <dbReference type="STRING" id="98765.A0A2R6R7E5"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS22670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="236" mass="25817" checksum="7DB296EF8E9B754E" modified="2018-06-20" version="1">MADKLDLSTCSSVADSQTTESESPSAPSMSALSHIPFEFNAENAKRAEEIISRYPPQYKKAAVIPLLDIGQRQNKGWTSISVMNYIANLLEMPPMRVYEVATFYTMFNREPIGENFVQVCTTTPCMLRGAYEILDTVCQDLGGIKPGETTKDGKFTVVEVECQGACSNAPMLVVGDDFYEDLTPETTKKVLDAFRKGEKPKPGPQSGRHTSENSAGLTALASKPYGPGEFCTEEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7G5</accession>
    <name>A0A2R6R7G5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000267">
        <property type="protein sequence ID" value="PSS22690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7G5"/>
    <dbReference type="STRING" id="98765.A0A2R6R7G5"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="563" mass="63643" checksum="5A2EE567CA4ED73B" modified="2018-06-20" version="1">MPELQTRVSKHPVLQPNNRPQSLSPPPDNIPVNDLNPEGLYYEFHSKLNGCPCNSSGQFLSDPNARPLPQARLDTDWTPYNSRLEFETAEFLFQRVKMGQANVNLLLELWAASLVPYGGRPPFASIHDMLQVIDSTPLGDAPWTTITAKYMGALPANPPPWMVATYEISHRDTLVCARNMLLNSDFADEFDITPYREYTGLLKRRYTNLMSGDWAWTQADTIAVDSDTHGAMFCPFVLGSDKTTVSVATGQNDYYPLYMSLGNVWNNVRRAHRNAVIVIAFLAIPKTEKQYAKNPVFRKFRRQLFHSSLATILSPLKRFMLKPDVVCCPDGHFRRAIYGLGPYIADYMEQILATNTVQGWCITCPTPRESLEDQYKGPDLRSREHTELLIQGFSLKELWDGYGVVGELIPFTNDFPRADIYQLMSGDLLHQVIKGCFKDHLVEWVNEYLKLTHGETRSNEIIDQIDRRIAAAPAFAGLRRFKQGRDFKQWTGDDSKALMKNRVGELGNFETDGVGALGGFETDRVGAILGGFETSRFSRSKRKLYTIVGAILIEAKPTHDDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHW7</accession>
    <name>A0A2R6RHW7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHW7"/>
    <dbReference type="STRING" id="98765.A0A2R6RHW7"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="613" mass="70618" checksum="9030EFCF46F4F9C0" modified="2018-06-20" version="1">MPLDIIDEVFSQLLPLDLLHLAQTTKEFRAFLMTRGASRYWKVARRNVEGLPDCPEDLSEPEYANLAFSNRCNNCLKLCQKVRWSIGQRLCAKCTRDYDSTDRPYDRFYEVMLGLTWPCDVSLHVALSFAFEGFEELRVIKRRKCRIELPEITAFKDKWIGLSQEAHLQFLKLVRDKQATDEKHARLCDIWYNSYKAARSDHLNASRKSRRKSIYEKLETLGWGDEFDKMSHVRLVRFTRLPEVKQPTVLTDRIWKRIEPQMVAYMEESKAERLLELQRPCLADRFELLKKVVLNMHRADEVFPFALDFALSLTEVRQIIDVPHDVKVTEEDLMTLLPVVPKFLEDWKRKGASHFSELVKRDVPVPDGIDPLSLAVATIFKCDCRIMKTYPDVLLHRCGLYWSYGKCEDQYTEAASNLLQYGSQSWARCKAVAGDIKNIIEACGEDPLQVTASHMDSVDARVTCLPCNKPGLQRIMTWRAAVDHKCNPDFSHYQEAKWEKVSEAHCIAVKDLEVTSKGLVRAAYESSSVFACAHCPRSDLNKGHVSLSTLKRHLLESHEIPEPSNEKDYVRHAGGPSMICRPVFLISPDYNGDVYYENMSGYLARGEAKVYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RID5</accession>
    <name>A0A2R6RID5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoacetate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RID5"/>
    <dbReference type="OrthoDB" id="9970474at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30321" checksum="1761D6736CE2D9E5" modified="2018-06-20" version="1">MSSTAQLQDISDYFQLVPVPWKCKGESFVFATYISKKASYPSNASFNPLEAGSSFADPAVTGEFHGGLGMIMVIRYKETPVGSYDELLWIPGTFTVPPTGQRALRITRMYVSEMPTIYNGRINWSVPKTRAHFTFTPSEHGAQGVPYSRISLAPLSHPDRPFFSVDLSPTRFFATARIPFDGSMIPKSLVYVVHPPVPESLNWKEDGMVGSDQWLGCPFVMKGKAGLFWGTGGLEGGKYGDEVGFPDVRPWSLGVWIPDADIYFATGDIIGKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLZ6</accession>
    <name>A0A2R6RLZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLZ6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7877" checksum="B5B08B47BA1E3275" modified="2018-06-20" version="1">MLWNHECLKNRAYIWTVTDLKRFDLAKSERVDQAVQSAIHLGPAASKALHPLDDQTLELMREITESSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPQ9</accession>
    <name>A0A2R6RPQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS31979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPQ9"/>
    <dbReference type="STRING" id="98765.A0A2R6RPQ9"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22297" checksum="2BBDCD2606CE0F1C" modified="2018-06-20" version="1">MSSYGAPTNPDTRPLPPGWVQQYDSKHPSVLLDLKPRFNRFYVNTAINPPQPSWVHPLGAPPPIPSPQGFAPPPGPPPPDNRGYNSSPYPGQGGYNQSPPPQQSWNSSPGYGGGGGYGGYQGPPQEQRGWFGGGRPQQPPQQVVYEQAPPKKSGMGMGTAIAAGGVGLIGGALLADAFEDHEDREEQQAYDQGYDNGQDNNYDDGGGGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPV0</accession>
    <name>A0A2R6RPV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000206">
        <property type="protein sequence ID" value="PSS32019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPV0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6839" checksum="1A4928FAF6805441" modified="2018-06-20" version="1">MSEKIPETREAPEASRRPEGEAPRYASRWESSLSRWPRDGLGMDSRGYQDVGPNHPRGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZ92</accession>
    <name>A0A2R6RZ92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000137">
        <property type="protein sequence ID" value="PSS35348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZ92"/>
    <dbReference type="STRING" id="98765.A0A2R6RZ92"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS35348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45064" checksum="74342FB86A7814FE" modified="2018-06-20" version="1">MPAEPRRTSRKATNEEDIEVKRARGEISCAECRRLKLKCDKKLPCGSCVRRGCTTICPNGSLSAGQGTRFILADTDQLHRKISEMSERIRQLEDALAIFQAGISSERHPLLRDELLSIKFGPEVRRTIDDEHTRNAMSQSIDALGTLTIGEHGETKYIGRSGGSEATPNGDIPPDILTAGDDLEDVPPLDLKCEKISFTFPFSLVQEDNEAIISRLESYLPPQPRAWALCETYLEQFTWWFRPIKRDELINEILSPIYKTVADPLKAAYHRKADAESNRCPHLLAVLYMVLAVGALVDLTLPSCSAEAEKYYRLGRAALSLRSVFDSPELETVQAVGLMAGYHSLCSSRYTLESAWSIASLASKLAQSCLALGRPPSVALSHIDCEPPNDDESHVGENGDVFHGCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZA5</accession>
    <name>A0A2R6RZA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000135">
        <property type="protein sequence ID" value="PSS35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZA5"/>
    <dbReference type="STRING" id="98765.A0A2R6RZA5"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="935"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120826" checksum="030AAC5EE71D6FB7" modified="2018-06-20" version="1">MEQSSHYTTTYTTPCTSAKADAWSVQIIWPNPTSPSLHQTCFWIASFFAVIIYSGENEHPRSEGEYLTVSCFPLLIQVVVCQVKRGRVGATLPAEPWDAPLSDDEVGSHPNSQSPSRSKSPSTLNSLRDSYVLIEEPNSLDTDEDESSLPYLDASEPQEPLFRGVSSSLFAPVQSPGLLNESTAASVHPQVDPSASLDLYFNAPFDDLPAIHTEDVSSSPETSFPSTPEPPREFPSHGSYLDTFSHRSTSIYTDIPSTLDYDLVHALSRLARTPSPQPEGAPCSLLTPDESTCEFQPGTSAQTIRNIVRPESTLRPRTLSSSSDTVSSTSDMDTLSPKTSSSRLSGSDPRASRYSENSDGAEFLSFPNSSSDDEESVYLSASFSRSSSIRENQSSGPLSHVGESADTDSGVDITARLSAIHDHSEPGSSRYVSADEYVDAGEGTSRGHGARSYNVGSSDGGQRSRAGPSDGYRSTGNFGQGGGGRGRGRDDDDDDGDRRGRGRPDVAHVYPSTSEDEESSEDEEEEDFAPRATSSRIVNQDIPLSSDDDVPLAQKIPSALNAQRTIRRQVREEHDQRKRAKSLRQPHHTDNRSQATPLPRLHGESISAGRAPRSSSPDAMPQVPRPRPRTNTMPSKASGPFSAGELTTKLLGVATAVPPLPSPRAVSSGHTSQELPSTQTPSSPKYGSFDLRHGHSVRAQGPIERYTTAPRSPMPEGIPPSQAPLRPMRSFHRPQTAGAENEIAPPVPVNSGARLGRSATSAGRRRPDEHNPPPPPPGSFPLPNQEANASLDRKRSSRSHSRKPSADRSRPSAEMERPPLPPLPLTEMKPVTMWQQRMFISNLQRFCQVELTQSSTARDVLEILQNQGALDNGAATGWMVWEVCQDFGMERPIRSFEVLTEVCNSWIADKTVNVLMAKKTLLAPKLSRAAIPSSSPLCSGFVQHEYKRGKWQKRWMELREHSLWLSKREGGKDQVNLCSMNNFDAYVVTRVSKAPKGFVFAVKSTDNISYFESTADYIHMFTCSEKEGENWLEKILLARSYVLHQERNVLSTNTAIAGAGAGLSRAGTRKHPRPSQPLVNFGQQIVPEPSPMAPVFEPGSLLAKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S016</accession>
    <name>A0A2R6S016_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000114">
        <property type="protein sequence ID" value="PSS35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S016"/>
    <dbReference type="STRING" id="98765.A0A2R6S016"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="194"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="664"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="879" mass="97878" checksum="7F6525D2C25B6CCA" modified="2018-06-20" version="1">MFNYESSPFAFWITRNSEPNAQPLFDTRITSLPPTPTLPVIPDDDSTALDSFQMIFEDRYLQLASALPLGTHIYGLGEVLSSSGIRRDIGTNGGKGTIMPMWARDAPDPIDENIYGAHPMYLEHRYNAASKRSQSHGVFLFSSAASDILLLTPPSSNVSLIEYRMVGGTLDFYFFSGPTPQKVIEQYGELVGLPAWQPAWAFGFHLCRWGEKTINGTIRHLEKMREANIPLEVMWNDIDLYDAYRDFTVDPVSFPAEEVRAFVRELASNHQYYIPIVDAAIPAQTSSADVYDPYTRGVELDVFMKNWDGAEYIGQVWPGYTVYPDWFAENAQKYWTEALSNWSNSGVEFSGIWLDMNEAASFCDGSCGTDADLSDTTLPFIIPGEPGNLIFRYPEGYNPDISGPSGNVTINGSLTYGVGANTTVSIERKDIVHMLGWDAVQVAPHAIDHEESSDETTVGPVKNPMLTKDGHSAADEGDLNLNAPPYAIHNGNGRLSHLILATNAAHAGGFIELDTHNLWGLMEEKATYHALKHIRPGKRPFIIGRSTFPSAGKYTGHWLGDNFSKWAFMYYSIQGVLQFQLFQIPFVGADTCGFNDNVNEELCNRWMQLSAFLPFYRNHNQRGAISQEPYRWDSVADASRKAISVRYSMLPYWYTLFANASLFGTPPVRALFWEFPDEPELFEVDRQYLIGSDILITPVLLPNVSTVQGIFPGRGRVTWRDWYTHDAIEVPAGGIATLSAPLGHINIHVRDGSAILLHAQPAYTITETRQGPYSLLVSQADNGYAFGTAYIDDGESLPPTDSKTLEFRATKHSLKILARGSFNVKERLETVTILGVAEPTTVTVQGKQVRSWDFIGARKKLVLHDLGLSLNDGASISWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3Y8</accession>
    <name>A0A2R6S3Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS36998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3Y8"/>
    <dbReference type="STRING" id="98765.A0A2R6S3Y8"/>
    <dbReference type="OrthoDB" id="2798177at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19572" checksum="63F9B7D2A2557BEC" modified="2018-06-20" version="1">MDDVPPLQLSMVEGKDSIMTINSDNKLVATTKGDPIHSEDITWAAHPSGPIDLEQELENHFRVNNPMPNEHLFSFQKGCSHSPLSRKVFLNRLKVAAKNASVPEPSGHSFRIGGTLEYLLAGVSFETVKVAGRWKRDAFLIYLRRHAQILTPYLHEKQQLHASFLRLTMATSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S402</accession>
    <name>A0A2R6S402_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000090">
        <property type="protein sequence ID" value="PSS36939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S402"/>
    <dbReference type="STRING" id="98765.A0A2R6S402"/>
    <dbReference type="OrthoDB" id="193860at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9940" checksum="4C09F0383E4BDE52" modified="2018-06-20" version="1">MRIKAQRWLNILAWRLKQQKAAAKNTLIASVQPLRIKLADFGLAKVLQHDQGFETKVGTPQFMAPEILGKDGYNKLVDSFALGGTIFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5D9</accession>
    <name>A0A2R6S5D9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5D9"/>
    <dbReference type="STRING" id="98765.A0A2R6S5D9"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="142"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="142"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="534" mass="58900" checksum="AFF804C9C6A02879" modified="2018-06-20" version="1">MPAYRTRDTRSESHPVQCTIVSDFTDPSPPTAGQSVLEVTTDAPLTPTVAIISPTPRAFTFPITHDAPYATPSSSPFEPELKLSSTPPPVRAFSPTSSIGSETSSLLSTPSSATSSQVSHRRRRSTVSDNERRPKKGDEDYIKRPENAFILFRRKCCEDRQQALEEGDDAPSAPVKKQRQADLSKTISQQWKGLPADERQYWEDLAKEKKKEHEHMYPNYVYRPQRVKKSKKGKGKHDGEQEANDGISFIMPVPSPPRSLSRGYSHGHGRRAASAPTPPPTYQTIQLPTVFMPSCPGSPTSVPRISRRTSYIPPPTDCDPSTHFEYLPQDAALPPSFHRPNFDPNFSFDSFPNFQFDSQNSFPSRASLQSLSIPPEQPSFLPHTVISPADSIASSIFSGSESAASSFSPASSHAGPFTPVSNLSITTLSIGQHSSQPEPECVPDDIDDISGGQLGFGGYSTWSPESLWPESSEMINTDDFDLTYIPPIELGMTMPEPACDSEGRQYRSMPEEPYSDMPGQDPFADLFAYENMSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5L8</accession>
    <name>A0A2R6S5L8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5L8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015350452" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8455" checksum="4E1EB27D9D9768C7" modified="2018-06-20" version="1">MACILCLHGCLYVAGSGLMAKNAGSGLGTRQGKTIESDECQRIVTNRRHRETKDELDDWYGRRYPAHLMRTEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5S4</accession>
    <name>A0A2R6S5S4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5S4"/>
    <dbReference type="STRING" id="98765.A0A2R6S5S4"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="680"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="589"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="874"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="931" mass="103837" checksum="00AB703499AD50AD" modified="2018-06-20" version="1">MNQGRRRTPAKFYQEDIVQLVDRPKVYGVVLRCWHDAEDLPPPAEHLAADPLLRPLKHGEVGVSFFSAGLDIPQREILLETKLQLVDRMYQPGDILKRSIEDVRSGIVTGIDVRGRVEHAISSEPIPGWKSMNEVECYIDVDMGDYIVYNDWVGQMFDEAMVEMESGALVRLPELSARLAVGERGPNILPPPTPGMHSLIGFLLGNARPGNQDTVLNVKRTVLAVAWLAINQSLDPAEAAERPRPQRFWHGADLSKLTLVRRRAEQAMRVGDRVNLKDSENSPVTVHGREGEPPGLVEVKTLVVKETRTLVHVLWQDGTRETLDAKDTVPYINPDEYDCWPGDHVIWKSEDSKRPAIIQSVNAVDRIALIRFTDTGNVELTSVLELDPHGASDWSSVSPVEGLGLHRGEFVFIHKEGTTNGAQKPMVPRIGEVEDWVRESLIIHLRENGHMGGWRRELAEIGNNIAAARGKDSNLEEGTLQRPRKDDASLNWFGEVVDLRLDGTVEVMLPDATLTTLPLERVTRLYDGLEQLEDMWGDDMSESGDSYESDGEEELWTQDANGRWVFSGHVEEDDWSTDEAEVDGDAMDVDEEGWSSSDPTALQSADTSPPHMSPFDIEPMTVRPASPDVPKDAIEVDEDDRGADSADDDDDSGWKRFKVIPSAPPDHAFFSSSPAQPSRNFLARLQKEYRVLSNSLPETILVRAYEDRTDLLRCLIIGPENTPYEDAPFVIDWMLDSNFPHSPPVAHFLSWTNGNGREGKVCLSILGTWAGDKNETWSASRSSLLQAFVSIQGLVLVKEPWFCEPAYEKLRGTEEGIVNSRLYSEKAYVLSRGFVRRALEIPLGGLEPEIDWMYYRNGKLQKVVQDARALVDKSRTTTPNAADTGNGDAEGSDSDSSDRDLAVPRLTGGGIITLERTLAKLQVLLDTHHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5S9</accession>
    <name>A0A2R6S5S9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v542</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5S9"/>
    <dbReference type="STRING" id="98765.A0A2R6S5S9"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="16"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="209" mass="23606" checksum="2B04775E58868B46" modified="2018-06-20" version="1">MPPTKQAPTRQAITLKGSTNLVTEFFKYAANTILFQRGVYPADDFHMVKKYGQTVLVTQDLALENYLEKILKQVNKWLLTGSVTQLVLAIISKDSRVTMERWVFDVNLVKQPTESAEPAPIKPETEIQAEIRNILKQIVSTVTFLPVIDEPTVFNILAYTSESADVPADEWVDTDPLAIEASKSQQVKLRSFSTDVHRIEAMVAYRYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S635</accession>
    <name>A0A2R6S635_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S635"/>
    <dbReference type="STRING" id="98765.A0A2R6S635"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="314" mass="30977" checksum="59C3BD7D0A0794EB" modified="2018-06-20" version="1">MYVGVFTTASLVDDGSFTLFPDEGVEDGPELGGVEDGGVEDGCLDTSSEGADNGAEDGGTDEGGAEDGGIEEGGAEDGGADEGGIEEGGTEEGGTEEGGAEDGGTEEGGAEDGGAEEGGAEEGAEEGGAEEGGTEEGGVELGGAEEGGVEEGGGGVIVEETEAGFGLGFGIFKDELRVSWLVLEPPERAALGLQAKTHDVIESDEMTADPAPAMDVDTSGVDVGGCIAELVGVGAVDVTDASVDGTEDAMLLLAVGKDIDNVSVLELGRAEERGVVDTVLGVVRATLELVIAVIADAVAADADPEEPEHGTKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE07</accession>
    <name>A0A2R6NE07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v13519</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001346">
        <property type="protein sequence ID" value="PSR70610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE07"/>
    <dbReference type="STRING" id="98765.A0A2R6NE07"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR70610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="510" mass="55461" checksum="29147B1EFEFEBC62" modified="2018-06-20" version="1">MTHVAASEVSSILESRIAGTAVGANVEETGRVLSVGDGIARVWGLRNVQAEEMVEFSSGVRGMCLNLEADNVGVSIFGNDRLIKEGDTVKRTGQIVDVPVGPELLGRVVDALGNPIDGKGPIKTTERRRAALKAPGILPRRSVNQPMMTGIKPIDAMVPIGRGQRELIIGDRQTGKTAVAIDTILNQKRWNDGNDESKKLYCVYVAIGQKRSTVAQLVQTLEENDAMKYTIIVAATASEAAPLQYLAPFSGCAMGEWFRDNAKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDKFGGGSLTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFFRGVRPAINVGLSVSRVGSAAQTKIMKKFAGSLKLYLAQYREVAAFAQFGSDLDASTRFLLSRGARLTELLKQGQYQPLSMEIQVPIIYAGVNGLLDSVPVDQITKWEAEFRAHLTATQTELLAEVATGNITPELEAKIKKIVEEHVSSFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE34</accession>
    <name>A0A2R6NE34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001342">
        <property type="protein sequence ID" value="PSR70623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE34"/>
    <dbReference type="STRING" id="98765.A0A2R6NE34"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="71"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="822"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="897" mass="96266" checksum="765CB7E452054F38" modified="2018-06-20" version="1">MAITKWIPFGGTQNSNSPAIPQPQEPLSVVTAADAKQFGLENRTHLIQQVSDELHVSLPPPALPLPLSAPSSPPNHPRPNPRRKLSVSENSHQPPPLSCSATSPSTPGLPIPPSPPTLLSALRSLYIHISRNPADKGTVAPRAFIDKLKELNELFRSSMHQDAHEFLNYLLNQIVEEIDEDRRKANSNSIGNGNESVGCTPSGEDLSASVGSLSSLAPPTSTTSTSTTHAAVVSDSTLVHRLFEGVLTSETRCLTCETVSSRDECFLDLSIDIEQNSSVTACLRQFSASEMLCQKNKFFCDACCDLQEAEKRMKIKKLPNILALHLKRFKYQEDVGKNIKLTYRVAFPFELRLFNTVDDAENPDRLYELFAIVVHIGNGPYHGHYVSIVKARGTWYLFDDDSVEAIKESEIPKYFGESNAGSAYVLYYQAMDLDVAALGVRPPASTASSATQSGDSNTGLSAASTAPLTSTSESPELDPMSPTLPPGLLVPGTTPSPSPSPPTFTSPLIGSPPSQQPQLYVQIPGTSPESTRTPTSPPPPGGSLTRSSFFNSIRRPPSIPSRIRSGNGNSSENRKSVVHAPPVPPIPLAPGSGSSIDGEANIDADELPIPALLPYGSPPSVVSSSQPNGKEKDKSWFKRKSFRSDKPPSSMAPDFAERSASASAVGEDMSSPWYKPTKRVMRRASEAGLSDYPSSIGMPSSAPTSSVMTHMSSASPSLRPVPEHKKSTPELAAVERSERRLSRQRPSTAGATVGRTSAVVVPPLPPIPPTPVRQPPSDQFTDKTEAPSQLEEKKVEVPDDRRDWGPMNGVTHNQVHHRPHTSHSPISPSGLSFSASNGTSSTLGTNAGESTSTVSSTGATKPKRATRKLSLSAPMLGFGRKDKDKRPQSPATMLAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEF5</accession>
    <name>A0A2R6NEF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEF5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8347" checksum="0151F8FBD33C0D6E" modified="2018-06-20" version="1">MDHGSLYRLGHVPIRGVPSGSVEPVQNTSAALARRGQTIGSRFSGEDCSLHNGIWPIHKQRLKTHLKDTLVRPHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFM3</accession>
    <name>A0A2R6NFM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001292">
        <property type="protein sequence ID" value="PSR71180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFM3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="9389" checksum="ABDC1990363CBCE3" modified="2018-06-20" version="1">MKIPHEGNRAPAADPTVDFNKKHKNPNGNLEGFRRAPASLFIRSLLDSLGYRKPANQELLCNDALFKLSVASAPLGKEVDEFNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFS5</accession>
    <name>A0A2R6NFS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFS5"/>
    <dbReference type="STRING" id="98765.A0A2R6NFS5"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="317"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="853"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="879" mass="97862" checksum="5ED30F075041A795" modified="2018-06-20" version="1">MSSPEPEDYNDSENAISQGSKKRRVQRACDICRRKKGLEIRLMKMEKLLLKLCPGINLSQALDDVSEKEPAWRAKGASKVASSSATQGVVLPTTVSSSLPVDADDLDSSDEELSAGKQSLERHLSRLKLDPGQPRFFGKSSGVMFLQNALDLKSEYDGVPKEKNPLPGPARLPYKRPQFWRAHPWILETIEPDTQQQEFPEKDLMDALIDLYFTKSNPFLPVLHRPTFESSIAEGLHFHDEGFGSTLLLVCALGARFSNDPRVLLDRIEDEHSAGWKWFRQVQWTRRSLLTSPRLYDLQIACLTAIFLNGSSTAQAAWTVIGVGIRFAQDVGAHRRKVYNPVRTVEEELWKRAFWVLVCLDRFNSSALGRPCAIHDEDFDLDLPVECDDEYWIHEDPQLAFKQPPGKPSTVAYFNCSIRLNQILAFALRTIYSINKSKVLLGFVGQQWEQHIVAELDSALNKWIDSVPDHLRWDPNKEDDVFFNQSASLYATYYHLQGLVHRPFIPSPRKPSPLSFPSLAICTNAARSCIHVLDVQYRRCDDPIYTNQFQQFSHVALFASGIALLLSIWGGQHSGVSIVPAREMADVHKAMKMLKALERRWHTAGKMWDIIYELACVGDLPLPAEPSPPPSHKRGRDSYSPTSSGSSAPSPPASHSIASAPRSDEPRHLAGSRRMSSIQHQASQFQSQSSFAPSDAGPSTSTLSHFTLPMHSTELGSLPLHATFGDDSSLPPGNNAWLAADHMQPGLAHIQPYPQATAPPDNLFSQTTEMDAYSSMMYDQVMSNLHGSMAPVSQYSSSQRVPLPTEDLDQLITTLGSDGVMFPSDGGALPTMWSSTGFDWDNRGTYINNFGGSTYHDLRSQPRPAGDSIQSSRQEAHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGB4</accession>
    <name>A0A2R6NGB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGB4"/>
    <dbReference type="STRING" id="98765.A0A2R6NGB4"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7137" evidence="2">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="177" mass="18642" checksum="50E82891588BF4FA" modified="2018-06-20" version="1">MSSTVSTTPAPSSGGSSGGSSAASTTISIPQTAPAGGLTITQPPQTATSYFKIAQGNVITFAWNFTDLIVTPTHLTVSAICDNGNTYPVGPSNGIIDGSATSVTWDLYSFQQANPNTPLAQATYTLNIWDDRGPGSRMEPGLLQENSQLKFALYSPQAYTPLSGEFSSYYIIRKICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGC5</accession>
    <name>A0A2R6NGC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGC5"/>
    <dbReference type="OrthoDB" id="3247268at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6337" checksum="B041254AD67A8E01" modified="2018-06-20" version="1">MQINSSSSPYEAEDDFFTHTRAQDDSSLPLSKRSDPGYVSDSAGRPRGQSESVVRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGL8</accession>
    <name>A0A2R6NGL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGL8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGL8"/>
    <dbReference type="OrthoDB" id="3234974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="197" mass="21342" checksum="C93049793D70C87D" modified="2018-06-20" version="1">MSVTDPRRREIFVNVPAVRGQTEQSFEEARIQDYVKAYTATGRPPQPCPEHPTDPAERVRLGLPPIFEPYIEVGGTPVSQSQGSSTTNLHINTSIAGPPPTDINALPEVQRFVPTSDASESGQQVQLQSIACQHVFSGFSFEELRCQAYKVGKLIVPEAYTTNTAASTPQPSMNGNAEQLQSITGNPVYAGHSFEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH80</accession>
    <name>A0A2R6NH80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001256">
        <property type="protein sequence ID" value="PSR71673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH80"/>
    <dbReference type="OrthoDB" id="2799983at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9675" checksum="3112ECA7FBEC4FAD" modified="2018-06-20" version="1">MVQVPAHPAYLKPSLASAGLRSYLSEVTQVGGDPDKAIAKVYELARLENPPLRLPLGEETVAGFREKLAHIAGEVDKYESWSKDLAAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHB3</accession>
    <name>A0A2R6NHB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHB3"/>
    <dbReference type="STRING" id="98765.A0A2R6NHB3"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="233" mass="27237" checksum="8187A684E2CE6C8A" modified="2018-06-20" version="1">MIRRQARERRQYIYAKSLEAQERQTYERKQQIKDALASGKSLPTELRKNAKDLGRDLAFDDAQTDAMIVSHFPHGPTLYFTLHNVALRHDLDSYKNTTVSEQYPHLIFDNFSSKLGERIQDALKYLFPVPKEDSKRVMTFSNEDDFISFRHHVFVKIPPKQIQLAEVGPRFEMKPYEIRQGTIEQTEAEREWVLAHYSRTAKKRSILTGPPPRPGASTHQEDSREPAKKRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHM6</accession>
    <name>A0A2R6NHM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v12228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHM6"/>
    <dbReference type="STRING" id="98765.A0A2R6NHM6"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="283"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="859"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR71884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="974" mass="108892" checksum="8B3F27EB4A4AA68F" modified="2018-06-20" version="1">MARRKRQLLDDSDSDSNSDTGNDFDDPGYDLNDPDAREERALFENPYNRKRKRKDGKEDAIYGVFASSDEDEDMGGRAKSKAAKRNDWTKAPAFVSGNKVDLEESMDADEKATASDSDEGEDKDDAQDKEAVEEVPDEEELDASAPPSPRTRDEEEDERPRFGGLGSNASKSGIGASKAGIGLGASRGIGASAGTSKSAFAGFSSGGASSFKLSSVTDTPPPEPASSSTLEAEDLNLPTAFGKSFASRPQRAFVRDGSAASGTSTPKPVNLSTTERLHFSKIGGTFGARMLEKMGWQAGTGLGVAAEGIVTPVESKLRPKGMGLAFKGFKEKTDQAKAEARRRGDVVSEDEDEIRPKKGRKAKGEQQERSAAWKQPKKTKKRVEHKTYEEIIADAGQEVPSGIGQIIDATGATPREVSSLADVSMASWTPTTDPMRLPELRHNLRLITETCKGDLDGLAREARNLEERKKWVRQEDERLRKKVQEEAELIARLQQVNLVVDDISSQAKDMASMYESSLDAFSPNFEKLIGLYPNEFERYRLDEIVVAAISPTFRRTLTQWQPLEDPGALVSNFRLWRKALKMTEPEERPQQGVQVYGSSAIASTPAVIEKPMTPYESLVWNAWLPKVRSCINNEWSPDDPQPAVRLYEAWSKYLPPFVRDNFFDQLVLPKVHKAVSDWNPRKHKVPLQTLVFPWLPHIGLRIEEVLHDARRKVKSLLRGWTVSEGVPEDLMVWKEVFDVGDWDAMLLKYVVPKLGSRLREDFRVNPRNQDMKPLQDVLLWERFLRLSIFSQILETEFFPKWLDVLHIWLVQPGISFEEVAQWYSFWKETFSENIQSMPSVSQGFTRGLQLMNKAIELGPNAPTQLPRPDHKAPLLSPKVAPTSRQGTPKPRPSRTQEITFRSIVEDYAATHNLLFIPTGKAQEKSRMPLFRVSANIDGKGGLLVYILDDAVWAPDGDEYRAITLENMVLRATKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI11</accession>
    <name>A0A2R6NI11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan halogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>melleolide F + FADH2 + chloride + O2 = 6'-chloromelleolide F + FAD + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:167712"/>
            <dbReference type="ChEBI" id="CHEBI:167713"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:67161"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI11"/>
    <dbReference type="STRING" id="98765.A0A2R6NI11"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140907">
        <property type="term" value="F:flavin-dependent halogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50241" checksum="72CA6B656627A649" modified="2018-06-20" version="1">MIYQPGAAVKLNQHNREGYTDFVSAGPQNGSWNVIRSEFDDLLLTYASKSGVSVFQETKVTEIHFEGPDNIRPVKASWLAQNGAQGQIHFDYLVDASGRNGLMSIKYLKNRAFNQSLKNTACWGYWSGTDLYKPGTTRENAVWIEALTDESGWVWFIPLHDGTTSVGVVMDKDIASRKKKLYDIENHDEKLHAFYLDELKHAPGAIKLIGNGVLRTRPGESAIKTTSDFSYCASQHAGDHFRIAGDAGAFIDPFFSSGVHLALTGALSAALTVAASIRGTASEANASRWHDSKVGTAYTRFLIVVLSTYKQIRNQNTAIMSDINEDNFDRAFELLRPVIWGAADVDKTLTQEELQKTMDFCCNVFTPTDPEMYEAVGARLDPALLQPHGPILTEVEIDKLLDQDDFEAKAVLSKVNARKPIHAMVDPEMDFASETHYGLNAVIERGRLGLVASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI48</accession>
    <name>A0A2R6NI48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR72003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI48"/>
    <dbReference type="STRING" id="98765.A0A2R6NI48"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23761">
        <property type="entry name" value="Beta-prop_DCAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="294" mass="32724" checksum="4F8EA18B96CE16B7" modified="2018-06-20" version="1" fragment="single">ISRLRIFHLCPKANLFLMGISHFLHCIRLHGIWMAATLRLLEIKAVGYRHTGWALAVPTTDRLANFTLGQNIDSGAAKRGILLPDIEAGWGFEVLPTGSDVFSIYQLDHLVYTGTRSGSIKCFDKRLSTRQKGQELLGGRFQAAKKSITHLNVINDWQLLVSTITGDLELHDLRFARETTPFMEFQGHYNNYQTELGIAVSPCQSFVFAAGQDQRIRAWSLRTGALISPQSNPTGKLQTHLFHHQFPDNVAAMQITDGSMNGYGSDGGGLSLWAVCGGMIYRYWLGQRMVGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIH5</accession>
    <name>A0A2R6NIH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NIH5"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="970"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1138" mass="125479" checksum="C4A0C4FB0A4F1925" modified="2018-06-20" version="1">MSGQTWPSSSSHSASVSGPSFQHQQQQQQQQYPTNRLHGYPIHASQDSYAHHSHVLPPIHDDYDDADEDGLGDLPSGVSLTGYGSSGMDGSGNGMQGMGKAGEKQVRRRSSKACDQCRKSKCKCERSTPQEPCKNCVLLGTACTFLGPSRKRGPPKGYIDAIEARLHQTEALIGILLASKDSRAKTLLEDLSQDTLAKEIIDRVNNSPYGHKGRKRGAPPSGRTRPTSAESKEGDASMGQSAHPSSEWQDLLTTQLNAKAAQRNTVTDDDEAFGDNEAKDGAMSLSYPVSDEEASEDRSSRPSLTLQPAVPEPGSAASGSTVPLSASLDRSDNRSDNDHQSRRQRRRLESDNPSAGPHVGSPSATSMSGRSQSPAQYTCAPPHPALLSKRSRSSLRRGSHSTSSGARDADADEESGDEEFGSGEDELAIAVGQLSLNEDEQVRYHGKASGLHLLGAAERLDGRNEGGIWRFPKARVWPPLPPTARTPTKSEEDWANCLPSLEMQEHLLELYFTYVHAQLPILHKKAFMDTFRKGNAASVTAHSPMSETSSTSGSQASVARPQRIPALLLLSMFSVAARYSSTGAPPPEPGSMWSAGDSYMDDAKGILDSSYSQSRPSTCQALLLLGYREVGIGAMAQAWLYIGMAVRMAQDLGLHKSADKWSNTGRTLFTPVELQERRRIWYGCVILDKYVATYIGRPVAISENDFDTELPSVDESDELEGWVPHPTPVFLDDASEKHPPIVVSVPGHIISCFDESAKLSIILSMIMQAIYPIRPHSFRQTEFARVEQLLDKWFIELPEPLRFDPSSPKYLTQPPHILTLHMQYWCTVILLHRPFIRHLSNASSKGLSPKSRENERRANSRKHYDLCVQAANHITAIVLVYMEHCCPRRAAPFLSYYVFTAAIMHVSTLTTYPDDPQASSGLQKCMDMLERMHRVWPSAWRANELLHGSKVLTQDRNVITLPALERQKRVADTLREDPADDSRLSSSQTFRQPQVYPEAGGSGQAQAAFPLDLSIHHAESPSYYQSYTTRWTPDNTLPSLSASLSTSVLPQQYSTGIVDERIQRNHDRPSQRYPQYWSDYSALGQIDTAYGIPVMGDMVPQHNGTPQNDQSMYVPDQYSLFIINNNVSALSDILTRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJS2</accession>
    <name>A0A2R6NJS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001152">
        <property type="protein sequence ID" value="PSR72603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJS2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="184" mass="19544" checksum="C304848798464DA6" modified="2018-06-20" version="1">MVLYVGHAIKHKPSRTTGRRRSSSSSIAPFGFSNFSIAGPAFGIGCPFPSGSDRSDLAIHPAGDPPFNLSDEAFKGLLHDIHTESASEIASIEADSDDVSDITLGDDLGCGDVEADANEGAWNLPNLPGPFDETQDIGNTEYPCRSDISDVQSQGGSAYDADESDDEDIVLDFLGRRAHCQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKF4</accession>
    <name>A0A2R6NKF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001127">
        <property type="protein sequence ID" value="PSR72859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKF4"/>
    <dbReference type="STRING" id="98765.A0A2R6NKF4"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="65182" checksum="20890EE0263FC171" modified="2018-06-20" version="1">MSSAVSDTTASPAPFSPFSTYSTATSGATSDDAPDLGAFTTVFRALTNFNPRTGPLDLSDSEGATPRSTWILSPSDYESEAAGGSTVWNHGPIASYLTSSSPETPPDSVSPTDTESAYELPAARVAERGDFDLHTIDDDILEQPSLGLAGALDFLAAERAKFAAQRDAAGMRGNSSATSDGTWRHVIQPRRKRRRKRNRSVQDSSVVRRPLTGEATTVATGDETLEGAAALYDDADDSSSESDEADPPNYYESTPATPPPGVRDKRNLRPLATDGHPKIHHTKSTPSLRLPMTMPIDARVLQLRNLAHKLRMLFPKDAAALSAILSNDQPDASDFVDPRGPVPRMKDTLIHVFIDHSNILIGFLSFLRRHMHRLHRKPKHMSHAALALVLERGRPVTRRVLATSSPLYQPVDTAEQLGYEVHVLQRVPDEGDGADRQHGSSSSGGEQPRSHRLSAQLTPQGKTFKPRAHSRGHVQQSSIGGGTSNESDSNSGGGGLTRRRYREQGVDELLQLKLHQALANADNVPADATIILATGDGNVGQFNEEGFLGCVRLALKKGWRVELYAWEGGLSKTWKREFGGNKRFEIHMLDRFAMDLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL26</accession>
    <name>A0A2R6NL26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001115">
        <property type="protein sequence ID" value="PSR73075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL26"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="5733" checksum="FA8B94FDE426C4CD" modified="2018-06-20" version="1">MAGRLLLPTPAYRLGRRGFAGKAEGAAAGFAQGSPSKGRGYALLQGSSLPPGKTDSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLE5</accession>
    <name>A0A2R6NLE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001115">
        <property type="protein sequence ID" value="PSR73068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLE5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6308" checksum="6145C65863ECCA13" modified="2018-06-20" version="1">MAEWLLRAYHPPALPSLPPPTTLPKGWLEEAKWEGRRSSSLPAKPRLPTPAYACLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLI7</accession>
    <name>A0A2R6NLI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001095">
        <property type="protein sequence ID" value="PSR73249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLI7"/>
    <dbReference type="STRING" id="98765.A0A2R6NLI7"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="413" mass="43682" checksum="37A95F21858D775B" modified="2018-06-20" version="1">MSTAPERNIVIIGAGIIGCTTAYYLSHHPSYSASTTKITVLEASVRGAAQGASGKAGGLVAKWAYPKELVSVSFPEHVRLAEQHNGVDRWGWRLVGCGTWEGRGEAIDHDAETGVGADGTRKSLGKTLGLEGSRERKRSDVGLPDDLDWVNEQLTNSYSSMAPAGETAQVHPYLFTTSMLELAKEQGVEFVSGKASAVEVDKSTRIVSGVKFTEPGTSNVQLIPATHVVIAAGAWSPKILPGLPIEGTRAHSITIKPSEKISPYVLFTEITLPPSGSSKHVQQANPEIYARPDNEVYCCGPGDNSAVPETVDDVLVDPKACESLRESVSSISKQLREGAVDRRQACFLPVVSSGGGPIVGEARNVAKGLVIATGHTCWGICNAPGTAKAISELIMGGNITCADLRKLDPARFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLN5</accession>
    <name>A0A2R6NLN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sphingosine-1-phosphate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLN5"/>
    <dbReference type="STRING" id="98765.A0A2R6NLN5"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29947" checksum="575EDD2F11AF5D92" modified="2018-06-20" version="1">MPSRDTISRVQTLLSSPVFDYLKSTLFLYVVLTRSVQAQRHLRARGLVPTVTDFWRWLSQRVLFLALRLPSMRKKVELELGQAKLDIEKKLVPQGKGVTRHLSLPSTGHTSEWILEEMAQMDVEGESHTNWKHGKLSGAVYHGGDDLCKVIVSAFERYCVSNPLHPDVFPAIRKMEAEIVAMCLRLYNNPDGAGVTTSGGTESIIMSVKTHRDWARATKGITEPEIVVPASAHAAFDKGAAYLKIKVHTIPVDPVTRKVDLKHVSRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLN9</accession>
    <name>A0A2R6NLN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLN9"/>
    <dbReference type="STRING" id="98765.A0A2R6NLN9"/>
    <dbReference type="OrthoDB" id="3361363at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34490" checksum="A82A70DF2CE5653E" modified="2018-06-20" version="1">MSYTPKSGCPMCGIVASAVHTPSHSPRSPHFPAGSTAPQVLWRDDNFTIYRERANPVSSKGHLIIVFNLHVPSLYTLSSSDLPLLVTIRDLSRRLLASLSPSTDYSSDYPPASPSSSTTPSHLLPRTVPTDSAQPVDNDAFRIGFITPPFRDSKIPVTDHLHAHAYILPADKMGWWRGVGFSGVAWYSIEDLIAEIREETSNNRIRSGPQPRRGPRPIDLVPSAGARYGTPNGVETTDTGIAVADLEDLDRSPGIRPLTLQSSPWSPDSGPSRSLTGDSARAAYNGSGGALVTGLMGDGRRTPTRSSTSDSGLLSPIKLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM29</accession>
    <name>A0A2R6NM29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001115">
        <property type="protein sequence ID" value="PSR73072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM29"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="15578" checksum="21A7C1E814C1D97C" modified="2018-06-20" version="1">MARRGERSSPLAAGFAQCYPSKRRSSSPNHHQPPTSLFFHPLVAYPPLAYRPAMATASLPAYRRGVGEAMRGEARGRLGKAWPAAPRRPSPRRVDRQAGRQAGRQAGRHSSLPWCRPAYPACPSHLFDRVLLARRIRDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NML3</accession>
    <name>A0A2R6NML3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NML3"/>
    <dbReference type="STRING" id="98765.A0A2R6NML3"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="350" mass="39756" checksum="D9DA6D9CC3F5A902" modified="2018-06-20" version="1">MSEDEDDYLSDKFLSGATTSGTAAHKTYSERRKEAQRLAAIKNEQNRKKTRRQLELESREEGLSKSLFERVKEEESAGQSKALAMMMKMGFKPGQSLGNRNDDAPSEPPATRQEQSQPPEQEDPVLAPKPGLGHRVVPLPLNEWTGKQGIGSVKRAASPSASERLAKMAKMKDSYDHNAFRDRARQEYEDRRAEGRLSPAQRTCLTLDEKDGREFNVLWLNPNNPETFPEGFLDELDDPELVLSLQKRQPDGSIEGRLKARMQADALQPLTSLEDDTPTASKKAEPRPISYSEEDVKEAVQFLRLNANDRLELVLDYLRRRYSYCFWCGTQYEDAEDMENNCPGVDEDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNR1</accession>
    <name>A0A2R6NNR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001037">
        <property type="protein sequence ID" value="PSR73982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNR1"/>
    <dbReference type="STRING" id="98765.A0A2R6NNR1"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="279" mass="29933" checksum="40FDE16E072EB660" modified="2018-06-20" version="1">MPGSDGSLNTDNARDSRSHFLGGPTEVLRGSESRRSSQILAIADSSALETIHSTNASSLDLSTLSVLPTSDRIRRRSEFGRARPSSIRPDVSLEPESVELSVLAPHDQFSKSQFHASGVALGIEEVSQRIGDPEIGPSLSNSVAPSVRFDDETGSTAPVISAAQRAIYRHKGRLHFAALCFSFFLEGWNDGTTGPLLPTIQKYYDIGFAIVSLLFVLNCVGFLSGAILTVYLTDKFGFGKNAQGNGFVGSLKEDATTKLGFLHASYGRVTTLSTNIFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP84</accession>
    <name>A0A2R6NP84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001006">
        <property type="protein sequence ID" value="PSR74285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP84"/>
    <dbReference type="STRING" id="98765.A0A2R6NP84"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="695"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="83486" checksum="1CEE8607BCC1215B" modified="2018-06-20" version="1" fragment="single">VLRIINEPTAAAIAYGLDKKGGESQIIVYDLGGGTFDVSLLSIDDGVFEVLATAGDTHLGGEDFDNRVIDYFVKLYKKKTGSDVSSNLRALGKLKCEVEKTKRTLSSQQSTRLEPESFEDGNNFSETLTCAKFEEPNMDLFHKTMKPIEQVLKDANLKKEDMDEARCTYNIVLVGGSTRIPKVQQLLKEYFNKELSKGMNPDEAVAYGAADKAPQHRLARLIGTDINLDVFQHSLSLNLLIMPSTSTSSQARADDLLGDINDLPDRPPTPSEHATLDELRDALFDWQDRCALIEDLYKELKIENLKLSATLAKGQKKVLDVPIATQAHEAEIAKYARKFIIVTPLVEFSIIHKTGRPAIDPRSPQRFASMAAFKLGTIAEIFDIFPEGSKVIPIIGMSDWFSEKFQHYHKDQKCKLVATLKLAMPIVFPTVSAAAWLSPEVRKTDPECIRLRANGLHAAFLYPPGREGIQSFACRNPNLPQLLRAALFNMSSLKPNARPLATSNGVKWGICQTEAEMIATMCTIAMHHLSYDRQFQAEGDHSGFRYMVFYQNVLKSLITKQHTPRVKAIKELWNKVAFDGVLPANVNNPVVADEDADEEDNRRFFERWDNDDMEEDGFGDDDLQEVGVGVHSLRLNDVETEPEEIRQAILPPSLSRAGASHNVTQPEHNLPPVFTPISRAATPPCTVSARLASLPAHSGEPSAEIQETLAAEEAPVPAISRKSVRKGAATGAATGVKGSRGAGRGTRRGRSRGDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPT5</accession>
    <name>A0A2R6NPT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPT5"/>
    <dbReference type="STRING" id="98765.A0A2R6NPT5"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="9546" checksum="9DC9B7C39F498772" modified="2018-06-20" version="1">MDKIAPASPSRILLAKEPKYVIHLSQYPDYSPSHRAEANFTHHPQAFSQASKVKLVRYQTNPTPNWGPGTKAASGTKRKRTENDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ45</accession>
    <name>A0A2R6NQ45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000970">
        <property type="protein sequence ID" value="PSR74664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ45"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="9547" checksum="76C785C0A9F81B4A" modified="2018-06-20" version="1">MARRGERSSLLAAGFAQCYPSKRRARPKAQHPPSRQGEAKPAYACLRLPTPAYACLRLPTPIGRRRQARHARQARQARQARQASGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQB0</accession>
    <name>A0A2R6NQB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor IF2/IF5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQB0"/>
    <dbReference type="STRING" id="98765.A0A2R6NQB0"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="227"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="360" mass="39687" checksum="7587B60893731B5E" modified="2018-06-20" version="1">MSEEQLFDPSLKKRKKKTVAFSEDPLGADADPTTPVPPVIDDVATNGDSVDMGPKTVHEQMAQSGRVEEGEDGDKKEDDELKAMFGDLKKKKKKKDIPLDLPEEASGTSTPVAGAADDLDFSDLKKKKKSSSKRKVAFDMEAFEKELNESKAKGGDEEEGEEEGGAAMDDIDEAELGEDPFARDVVTLDAGSEPWLGSDRDYTYPELLHRFYAQLHASNPALLTSSGKRYTIAPPQVIREGNKKSIFANVSDICKRMHRQPEHVIQYMFAEMGTTGSVDGSGRLVIRGRFQPKQIEHSLTYSDAVEYVTCKTCKSPDTLLTKENRIFFMACESCGSRRSVNAIKTGFQAQVGKRSKNKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQZ7</accession>
    <name>A0A2R6NQZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000937">
        <property type="protein sequence ID" value="PSR75064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQZ7"/>
    <dbReference type="STRING" id="98765.A0A2R6NQZ7"/>
    <dbReference type="OrthoDB" id="3227343at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072:SF52">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="211" mass="23426" checksum="41067DF6909FFECB" modified="2018-06-20" version="1">MAKLRKLHVLLLLNHNNYVGLIHEKELLAIIQALRKWCVDLLGIPFTVFSEHRTLENFTEQKHLSQRQARWQEFMSQYDYTITYIAGIDNAPADAMSRKPPPADTVPASTVGLIWEATTALSNRLSPPLAAVASVSSLQIRCDSERILSVKTGYLADSWCAHLLDSLWDSVAQAAIVDESSGVSSLEALERGWLDNCARNGVSVCLGMLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRA7</accession>
    <name>A0A2R6NRA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000922">
        <property type="protein sequence ID" value="PSR75168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRA7"/>
    <dbReference type="OrthoDB" id="10574693at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15392" checksum="2BF5486853F93575" modified="2018-06-20" version="1">MSSLDDISERSDNDFSFNSTSNVSLRSGLYIITTVEGIPLGRDTKGVMDAALVVTLPKHQPAPKIALRLARENEQGYEWVIEPQEGENGVYSIKNASVGAYLGWEDFWIAPKIQDEDDEGLSAYRQASPRHNFETQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRG1</accession>
    <name>A0A2R6NRG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRG1"/>
    <dbReference type="STRING" id="98765.A0A2R6NRG1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="224" mass="25465" checksum="407606525C89DB73" modified="2018-06-20" version="1">MVVSSTFVLLLQPTMSIDSIIHSERRNGRSIVTITILLITALNVLLNTDTVALSLPNWYTVNNLVVDRPHPRDSAATWDVGPIRQATMTPEESVHYKLNTVAGEEEWSTILPHGRGVVYEDREGEETPYRLAMFHQLECLAAVREEMMARQAGKPVSERARFCLNYLRQSIQCHSDAHLEMVRSEYGGRAVLPYTTRTNCLDWEAIWGRAESHFHSRRNNSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT87</accession>
    <name>A0A2R6NT87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000858">
        <property type="protein sequence ID" value="PSR76224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT87"/>
    <dbReference type="STRING" id="98765.A0A2R6NT87"/>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="406" mass="44843" checksum="AE401A9CAD86A98F" modified="2018-06-20" version="1">MVQQSKHSSGWVHKALWTADLKIMGKPSKFSDTSSASKPSANASRSVIKTLLGSISCLAVVLIFIIPPSSKILFPAFHYVRETGMYPDGLPIRRHYTGHRILDFIFTGLAGFFSAAVDGNDEATHLFCLWFLPQLCGVLVFCYWEAGRAGLNFVRLPTLVSILAQLSTAGVILPLYFLSYVRNMPSLPSTLPNDSVSRARTVLPAVVLGYVVPSAALFLAPTGTSLDTKQIIAAIWQPFPIYIMVFHNLFRNVDSFLRGPTSPADESNAASFWIKCSYYASALLSAIAHLTIVLPSLFTSNPAHSFANVFVPYYMHPYLPIKPLSSDLPAYRLTVRLLFQHDWLTMTMATLVFFAWSNHVTRTTSGAPWATRMVLLTLIGGPGTAVAWAAVEREEKINNHQRAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTF6</accession>
    <name>A0A2R6NTF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTF6"/>
    <dbReference type="STRING" id="98765.A0A2R6NTF6"/>
    <dbReference type="OrthoDB" id="2757553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="2">
        <location>
            <begin position="167"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="415" mass="45763" checksum="9E5C791B49B3A00C" modified="2018-06-20" version="1">MALSEEEWVAELLRRITAKHEEKMALDISRNQTVKEISSLEASSKKAADEQPPAPQHRDQAIQVDRQTVDIAIQTDPILAAPAVQSRPLTSAAARPAAQTANAPPQRPAQASESRPANDAGRRRQPTTGRATSYYELPHIPAARRQVLEAFPEVYVPAGSAEDEIEFSRPELSAKLGGGQQGVDGKFGHKLKPLAQKHELSGCIYPQRHLNIWLPRKPGEHGYLFLGLRGPGRDHEKFLTATPRAMFVCEGKSRWRYYGLYTAERNPERDLTMEEWQALPDEFKLGDSSYSAMTLCKRLGGSIYDSLFKSDKPNHDKQVAEIRTDYDEGRLRVPCITLQCVGYNEELIADLKNDAAKSTSSGTNVRKVTLRLGDPSAHASLGKRKRAALAESDSEDNLDIPAAPPRPSGSASLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTH0</accession>
    <name>A0A2R6NTH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000848">
        <property type="protein sequence ID" value="PSR76365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTH0"/>
    <dbReference type="STRING" id="98765.A0A2R6NTH0"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="171"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="836" mass="94778" checksum="7AD0F33212CA5F73" modified="2018-06-20" version="1">MADVAPPIQHSTSQVVHPEVHDHGDPMDIRVDHKYLCMETAGSFVGPVLLKEFMKRFMNIPGRRRKIPRADFSNVLKGTSNADMYDSLISAIKKSKICPRMVFRRLSNITQEDLALRPDLAGFNANDGEPSDNANIWSSMQLCIDNRTEDAFDVTYDPNDREGLRESEGGSTKFLGQMIHYVREQMSHQHRVFMFSLHTVHDSARLIRWDRMGAIVTEAFNFVLQPQILAEFLFRFSLLGPEGRGLDSSVELTGPQECHAFTEAVANYLDSFGERKPPHFDSTLDASYPTCKILFCDSGSGERSSFIVRRPFSEIPFPCGRATRGYIAWDVGRKKLVFLKDTWRPEESSRLSEKEAYETLAEHKVPYVPTFLIAEDVRSSTGEPQRTVTQDYSDIPFGSRCAHLRPHIHHRIVQELALPLVMMRRSKQLVQAIRNTLVAIQAAYQDAKILHRDISMGNIMLDSNLNGILNDWDRAIRLSASEEHHAARTGTWRFLSIEQLRSETKAHEIHDDLESCFWVFLYAALHHFRHQPVPFDMYVFEEVWDRKDKDGTMHYFGGGWKRAALSLGQITDLKFDCAPLTEAIHHVSSIFEEFHGSAAGSSSSDYFGMRARAARAKAHAEMEDPSPLIKFFDAILDREDWPQEDDAVFHPYPPPKVQSPRKEEEDSYSGQNSLYTNSDHSPSPIANSDKAPEACDSQPLISEDRLGYTKHDAMISQPQPTAPQAVAVAEYSFPLALTSEQMNGKPSRTCDATCIGKRLAPGSADYASDEPKAKLPKLVRRNSKQKHTTRTHAMTLRPCAKARPPLYTHNTSRTRDSQATLYGDEWFLRGTYAYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTT3</accession>
    <name>A0A2R6NTT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylulose kinase</fullName>
            <ecNumber evidence="6">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000841">
        <property type="protein sequence ID" value="PSR76541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTT3"/>
    <dbReference type="STRING" id="98765.A0A2R6NTT3"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="7">
        <location>
            <begin position="133"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="8">
        <location>
            <begin position="297"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR76541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="563" mass="60828" checksum="8C26753D1284EB6B" modified="2018-06-20" version="1">MSSPLFLGLDLSTQGLKAVLITEESQVVHESAVNFGSELPHYGTTNGAIRGPDPGEVTSPVKMWLEAFDLIMNKMKTAGVNLGRVMAISGDGQQHGSVYWSSAAPDLLSTLDPSKSLAEQLSPTAFTFQRSPIWQDSSTTRECRELEDAVGGPQVLADITGSRAYERFTGNQIRRLRLLHPTLYAETARISLVSSFMPSLFVGAIAPIEISDASGMNLMNVLTNTWEDQLLEFCGGDPHDLRQKLGGEPVKGGTVLGTISRWWVERWGFNPDCIIAPFTGDNPATVVSLSSPGDAILSLGTSTTLLLSIPPLSASDPPHRFTTSHLLAHPTTPGAHIAMLCYKNGALAREQVRDRYAGGQWSTFNQMIEASTVGGGGGGDGTMGFYFPLPEIIPPNVQGSFFFFSSTAAAIPEPSIPPTLHPRLILESQLLSIRSRIAAILPAHCPPLQRLVVCGGSSANPVIRQMAADVLGMRVFVAVTEQGAAEGGAQLARYAWWRSSMEGGTFEELRAMDEGYCEEGERFRCVAEPKEEAGRRYAALVERYRECEERAVDVWNAAQSVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV25</accession>
    <name>A0A2R6NV25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000802">
        <property type="protein sequence ID" value="PSR77304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV25"/>
    <dbReference type="OrthoDB" id="2669066at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="408" mass="44317" checksum="92AF3DF5E26CD57B" modified="2018-06-20" version="1">MSAPSSSKAKATASKVDQDGRATKKAATTVGKKAAAATVEMDVDATFTDQFSQWLQGAGAPGGTNWFYSRVWGDRRGTLTETEVALLLAAVRDTKDSRVLGVFHMLKNNIENQTVLAGQVQKSFQQGRIPSTSVSDDGFSIYWVRKNARVAGSKEKELLAVAKGGFRYHGVDFINFGAPVFFWPPALTDVYQDNLAVDASAMWIVTWEGNVGEKELDDIRAVIPAREIFAFRLFNRAGSPSTQWGIRAIGIPAGLKGTDVKIGNKVDLTWAPHCAFCGRGAPLETPHSHEQCPQIGVQNKFREQAGYYPIKVTDRGYIERLDVEIPEDLPKAIKGLRGRLEKVEGRLDKLEKPDKADDKKRKADAAPEASTATPKKKAKKDKKKKAKQGQGSGAAAPTNAKGKGKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWP5</accession>
    <name>A0A2R6NWP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWP5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWP5"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="400" mass="44638" checksum="C7FF884D567ECCA7" modified="2018-06-20" version="1">MSAVKRRSTVHDLASLRLHPDGTRVANTERNTRPRQAKNATKDSRGNWIARDAGGLGQVKQRRAARPEQGGGGEEQVDGNGEGDEVRRSSKAKGKQRAREEDGEVDEDVLRDPRAKRRKHFQADFNFWDPARVHGGDPEELLLPPFQPAVSFPTSVSLLSVLLESKFTEVSLQDLLKCIHYFASTYYSNMGQLRNDTREYRKEKKQRRLKRLSGKGTGSVPAPKEGSPRPNRSKTQSEGSSSSSEQEAEGSENEEGDTTATAGRPKHKRAFRRARTESGTDMYKIFDGSALVAIGRRSRVTLSSSLTRWPGMLLQEHVTDLLSTRIPDGWEEAMAKTESRTVPEEKRKGKAGRPKKVRCTRVSEEEGITEGNDEEIVDDAQGNSDSDDGDFIPQWSYLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWX8</accession>
    <name>A0A2R6NWX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000732">
        <property type="protein sequence ID" value="PSR78662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWX8"/>
    <dbReference type="STRING" id="98765.A0A2R6NWX8"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60027" checksum="9C7AE18FEB25CE52" modified="2018-06-20" version="1" fragment="single">FQWDRRHASSTSGPISPLQEFIPMVLQVAYTLASKILPSERYVHVGVSILGLVITYAFAQGRTTDRERDLHARTIIVTGAFTPLGLTLVSNLASRGAHIIAISPYPLSHPQPSLLIPALRTATNNPNIYADYADLSSPASIRDFCTRFLTGDDQRLDALLFAHEYQGIGSLFSSKQSHEEKREVGSLATFLMATLLLPALLVAPVERDIRIVNVVDPFYAAATPSFTSHLLASMTSSSSASSTHRSVFLHEGYRALRSIVFTRHLQRILNALPNRAPTLDPSLPGKDDTRPPQAAASTEASATTANPFPSNIIAISVCPGISRSQTISNLFGAEREGDPEGWSRFGTVLYFLFFPIIWLFSKGSNMAMQSILHVLFLPTPFKRALAQASAAVNPPSSEPSEKPEPSANASGKRTRVEDMFTEVLKPGALYRECSVATISVAPLPEPPKQAQDAEQKAKADKKAGGGKKDKKVEEDLVIEDDGEYGGEAIGRVVWEWYELHLKTWEKAEKDKEEAEKDKEQVNKSKEHVAEEQEHRDKTDRSKPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWZ0</accession>
    <name>A0A2R6NWZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000726">
        <property type="protein sequence ID" value="PSR78761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NWZ0"/>
    <dbReference type="OrthoDB" id="2972126at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051685">
        <property type="entry name" value="Ycf3/AcsC/BcsC/TPR_MFPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943">
        <property type="entry name" value="CELLULOSE SYNTHASE OPERON PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943:SF8">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN MJ0263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1399" mass="155745" checksum="AE90690CE97707A5" modified="2018-06-20" version="1">MIGVTHVQDTQSDMLQTFLDLLMLFPDALNSLRTTQEWDSTTAVLIKFREGLPLLRPDNPLLPMRLVFIAHALMRRFQALGEIADIDDSIKYLDELVAIPSSSRFGDGFIDDGMPLQLTTAQSLCLLGDALMLRFERSKNVEDVDAAIEKYRIALTLISSYDPARHPMCLMPLGRALQLRFKEHQRKEDIDEAIQCQREAVSLSHIQPDEDESQIAKILAELAALLVDRYNAFHLIVDLEEAIENFQAALAPLPDNSEKQPGFLRNVAASLYLGFKATGQVEDLNRAIDHSRKAIACLESGNVPLDEGEILRSLAKSLDQLGGFLVDRYREVGQIVDLEEATESYEKALVFLPDNSEKQPGFLRNVAASLYMGFKATGQVENLNRAIDHSRKAIACLESGNMPLDEGKMLGFLAESLDQLGGFLVDRYREVGQIVDLEEATESYEKALVFLPDNSEKQPEFLNNLAVSLYVSFKATGQVEDLNRAIDHSRKAIACLESWTVDDVSSRIQIKRRMAVCLDTRADSEWSNQAEDMEGALRIRRELVALTEGKVGHHEDVLYLVNSLHSQWLQDPGQLCAFDEGLNQLRNVLQIYGHGRDRLVLLHQLAAHLLDRHRRYDAPEDLEEAIAYLRELLALTPGGHVRRAIYLSTLVDALCQRFRLFGRTDDIDDAVGSAREAVASARSCHSRHDLSICLSMLATSLYDKSGHCQSHNIFAESMTIWREVASLSPENLAAAYTLASFTSLRQVRLGQPSDDIEHLEKFLTEIPAGHPDKLLSVSALATVAVAQCRLSGGTKHQEEALNRCRESVAAYEQFPLGDDYCLSVLNLATAYRLNGNYEEAATRFEQAADLRYATPHYRLTAAEEWADSARQAGHSSSLRAHMKALELLDMCLTSTPTIDLQHQFLTKKTSTRAANAASCAIEKEELETAVQALEQGRALIWSRMRSYRHPIEKLQGLNASLAEEFKAVCQQLEHLNVSSESNPPRMTPIPTISATPHTAVGFDIKVTKNRQLLEDYERIISEIRQLVGFSSFLQVTPFPTLQTAARGGPVILVNVDENRSDAIILRATEKPLLVPLTGDLSAIVGKLSSRLVVVDRINRSRNEDRYDVPHHPKQFDMSNILQILWQEVCQPIALALQKMGHAEGSRVWWCPVGRLGALPLHAAGIYNNKGVLMEGFPDLYVSSYTPTLSSLIASRETAVKGGSGPRLLAVGQSNSLPKVKAEFFKLKSLFPSDVLRIRDGEGAESDKVLGHLRDHPWVHFACHGSLDTDSPFKSGFILHDKKLSLRDIIQAKLPNAELAFLAACHSAASESTSKTPDEVLTLAAAMQFCGFRSIVGTLWAMRDEDGPELAEKFYKHMLRNGLDNMDVRDSARAVHLATKSMREAGVPLHRWTTFVHVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXC6</accession>
    <name>A0A2R6NXC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXC6"/>
    <dbReference type="STRING" id="98765.A0A2R6NXC6"/>
    <dbReference type="OrthoDB" id="3270104at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="314" mass="33843" checksum="DCC5E3C2F9E218BF" modified="2018-06-20" version="1">MATSTSKPCFCSRVIYHRIILEVLYIIQNLSQKVVSLKTGEAVLFAPNGLGRRGDEEADTSTSLASVAAIGEGHLVVRSRQRVTRDGGHSLLAVRNPETTTRLGRVARDPTNEGTRADSDVAGDTKVKIGPTDAAAGTSNTAWNPGWVPWTAENSAGLGTPPGLSRAQWGGTETIVPPLPYLAGSVAPASSNATFAAALFEADASNINPPIQTRPQAAVSSRVIRMNGPRARFVPLIKYLQGLPSEGPTMKALRKYFRRHQPLVYGDKLKKINSAITEAKALEIIVSRYFPMPTNPEKMKERLALVPGARYVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXT2</accession>
    <name>A0A2R6NXT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXT2"/>
    <dbReference type="STRING" id="98765.A0A2R6NXT2"/>
    <dbReference type="OrthoDB" id="3171382at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="351" mass="39639" checksum="07AB8327EF5F3D7C" modified="2018-06-20" version="1">MSQGSTSAPPDKPAPQQMTLYWQQLPSIRILRPPKGKYSARVDERCFTYCSQTVRGRTEQTEPWCRSICLRKIFDHEVRKILGAHARDPSTSSHSNSQTISDDVEFKFPLPPEGQPAPIPDTSRAAGGTDDSDDAYMDFDSAWSPSSIGKGKQHQVRYWQDGWYVWLSKNRWAAQEKMDLMMYDLARQAEWQKHKEKMNADWEAYQRQGQDVHSDTIAEPVPEDRGPVVGPMPTQVEHTPIPPNPTNFEWNVVPSPGPPFPDISSQSFLAPVPPSLTVITDPLKRTLLPTKQLLSVTYNSLQNGDQLLLAKRLWEKAKTPDPFILVGSVIRKTWKAWSGGSEDEEGGNTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYR9</accession>
    <name>A0A2R6NYR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000645">
        <property type="protein sequence ID" value="PSR80623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYR9"/>
    <dbReference type="STRING" id="98765.A0A2R6NYR9"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01397">
        <property type="entry name" value="DHBDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR80623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="14153" checksum="27C45CDC48491082" modified="2018-06-20" version="1">MDPTPTVPALDLFSLSGRNVLITGATRGIGAACALALAEAGASLCLAQRPGSTNLETFNSIAALGRTVKTVECDLADLDSVRSLFQKALEAMGGEIHVLVNCAGIQRRSPAVSFTERDWDDVRCPVIFIPCPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYW7</accession>
    <name>A0A2R6NYW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYW7"/>
    <dbReference type="STRING" id="98765.A0A2R6NYW7"/>
    <dbReference type="OrthoDB" id="2745518at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="152" mass="17802" checksum="C0C32266D3227F75" modified="2018-06-20" version="1">MLDGNLPRNQVETNDLTQYLMARDIRPGHEQPTFDWSLFLEELCDVETDAEGAWDKNQWYCTDCILGLIKLRLRIWWIARKIRDNRPAMDDCWYGYNCRTQVHKYAHAGKLNVSAVVIRAKLRMRFDFLAKSGQDRLRQPVPQNVNCGQSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZK1</accession>
    <name>A0A2R6NZK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZK1"/>
    <dbReference type="STRING" id="98765.A0A2R6NZK1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="67"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR81332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="258" mass="28529" checksum="5AE7E2ECD1FB5E48" modified="2018-06-20" version="1">MIIWWIRSYNDFEVSGNSLERIQQYLVIEQEPGQQDHGVPPAVWPSSGEVRVENLSARYSPNGPTILENISFHIKAGQRVGIVGRTGSGKSTLTLALLRCIYTEGTVWYDGIPTHTVNLDALRSNITIIPQVPELLSGTLRQNLDMFNQYDDAALNDALRAAGLFSLQHLHNENRLTLDSKIASAGGNLSLTAPSATRHFPDEPINEFVQMVLDAGRLVEFNSPEVLLRDKESLLRALVEESADRDELLAMAQGGIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZQ6</accession>
    <name>A0A2R6NZQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZQ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NZQ6"/>
    <dbReference type="OrthoDB" id="10558209at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="166" mass="18661" checksum="014B98D6DA2BBF2C" modified="2018-06-20" version="1">MDWSKAFQHSFGLQQALPTVPNQSALPNFDESNDGLSPWLSHHTRILVLGTLIPGCIALLTLSYDLLACIRWPVCMRKLAKRVKSPFRDFLTLDDLQESEPRPVLVPPTWKIRTLIVLSALEAICWAAFFAYCQFLDNAGTAYVIQTGVGLLTWVRSLVPYRSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0B3</accession>
    <name>A0A2R6P0B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHLCEN_2v6149</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="MLYV02000600">
        <property type="protein sequence ID" value="PSR82079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0B3"/>
    <dbReference type="STRING" id="98765.A0A2R6P0B3"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PSR82079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="275" mass="31560" checksum="8F7719EFD929F660" modified="2018-06-20" version="1">MQSLVVARSMLARSSALRYNAVRTFASSSSRLQAVPTEKPVLQKEFKIYRWNPDEPAKKPTLQSYTIDLNQCGPMILDALIKIKNEIDPTLTFRRSCREGICGSCAMNINGQNTLACLCRIDRDSNKDSKIYPLPHMYVVKDLVPDLTLFYKQYKSIEPYLKNDNPPEGREFLQSIEDRKKLDGMYECILCACCSTSCPSYWWNQDEYLGPATLMAAYRWMADSRDSYKEQRKEKLQNEMSLYRCHTIFNCARTCPKGLNPAQAIAKIKLELAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0C1</accession>
    <name>A0A2R6P0C1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000616">
        <property type="protein sequence ID" value="PSR81510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0C1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="12167" checksum="AF1308E101B3DED3" modified="2018-06-20" version="1">MVTTIASSSLNLTTIYPVAGSAICHFESAQNKGKPIIVIRLVKILEPLVVSPETPNFPSLKEGDLLRGKKRTWHYKTADGARRSIRNDCRRGLRYLKEYPEASFDYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0L0</accession>
    <name>A0A2R6P0L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0L0"/>
    <dbReference type="STRING" id="98765.A0A2R6P0L0"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="3">
        <location>
            <begin position="351"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR82575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47738" checksum="6F9CA05F2DBA14A8" modified="2018-06-20" version="1">MSAEQLRELFPFLRDKNPQVRQIALTNLLGHTPKDSPNRDIFFTDLRGGGLQGKQDNDVIRDLKLLCRDQLATAHDAFRALINLSDNAQVAISLSEPSFLTFIVAYILNAQSILADLASMLLSNLTSSAATCATVLSMKVQIFSYPESPSKYLPVQSRSGTCPAPIPYPEGEPTEVSALPLLIEAFVQGASVDEEDDPGKRLRKGNLNFLSSVFANISIIPSGRMFFLTPGHSDPIASEGNLEYPLSKLLIFTEHKDTIRRGGVASTIKNCAFYTQAHRAMLSPDSVKVTVPPSILEAPGMDLLAYLLLPLAGPEEYDLEEQELLPPSLQFLPETKKREHDPVIRLTHVETLLLLCTTYWAREYLRNHGVYEVIRPLHENEPVDNVSEHIERVVNFLKRDEGSDTKIDDTDNGAKIEAVSDDEDDMIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1G1</accession>
    <name>A0A2R6P1G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1G1"/>
    <dbReference type="OrthoDB" id="2769307at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015346639" evidence="1">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="10406" checksum="116D962A76EC88F1" modified="2018-06-20" version="1">MFFSLAKSTSLLALLAALPALANPVQPELERRALVLTSSIAVPKTGTTISPGDSFTFSYIPIDSCFEAYSAFTVWLLATSPTSADLNSTMGFSQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1P2</accession>
    <name>A0A2R6P1P2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VPS28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1P2"/>
    <dbReference type="STRING" id="98765.A0A2R6P1P2"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR83077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6737" checksum="7B1C71E89BC6C30D" modified="2018-06-20" version="1">MASTISLDEEVRLYTTNPEREKYGLLATLFGIIVALDYLERAYVRDSVTAAEYVTSRCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Z3</accession>
    <name>A0A2R6P1Z3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Regulatory protein ral2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Z3"/>
    <dbReference type="STRING" id="98765.A0A2R6P1Z3"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR83885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="75065" checksum="4959488F450E0F79" modified="2018-06-20" version="1">MYPISDLTAFCRRTTGDVPPKLVGASTTVVGSKMYLYGGRLVAERKMVSDIYVFCLQALKWEKLPQASDENVPQARYFHSADTWNNHLVIFGGMAIQPLSDNPEDLCVLNDVRLFDLATNKWIPAPHNSPSPLVPKARYAHLSSITSNRLFIIGGQDLNNVWLDDIHVYDLLSRKWVQRRDYPRHCGTYRSVAVTATKRVRLPQEEGRRSSQPNQAGTRFSVDKSAPPAPDVTSSDSLTHLPYSTDPTDEYPCDVFLFSNYNFTDVQRELEIFSPLPGSDFTVSDRSASMTGAFFPPGLRFPTGAILGTHFIVAGTYLSQTFQSFSIWALDLVTMTWSRIDPGSTLSGTSGSWFRSCLWPEENKFLVFGNRHGNLVEDYNRRLLSWDHVISIDLEAFGVYQPPPLVLPLPQQELGLAALEEGILADFEIICDDGRKIKCSRKVLEDRWPWFYEQRRLFLDAAARAIAAIPSADPPSPLPEFPNGREREKQPDPRLSPRSLHLSEPYPVTLAFLQYLYSMSLVTPLQHAPAVLSQLLLLSSTYELPHLQSLVKHAMHRALSFATSVGIYGVSTLCNCRSLQIRALRVVMAYSQKRPNAGRSRDKDGPGTGGTGGAGGTGGAGGSRPNDSGNGAGPGPGFGSPIDKPFAARPRGMSDASYMRGPTDSSNVRVFSNGTGTQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5J3</accession>
    <name>A0A2R6P5J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5J3"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR85868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="157" mass="17886" checksum="929560F612A0B388" modified="2018-06-20" version="1">MPASEIDDIFAAKGKVNPTPSTSKLPDPASNKEKKQKKRKRAAQVQADQQPPIRTAPETVIDPSLRLSVPTKQRAKPEADDQPEKKRRKSQKEDEERFKDSRGTGPSMFSPVDVPICLYHAVPPRAQDRGRILNIQRGRTWHHRSRRRYAAASFLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC20</accession>
    <name>A0A2R6PC20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC20"/>
    <dbReference type="STRING" id="98765.A0A2R6PC20"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="174" mass="19188" checksum="322BD6B96C74D135" modified="2018-06-20" version="1">MKGDIPELYFTPTAAELKAVQSSLAARTQSLANAPLRTQAMRDADQKAREARWPTLPDQTPPKRELKVSDPKVRDLNLSQLQLAPSSVLHLKFEDDSLNHVDVPAPLEASVLARAEDLPIYSANDSSPRRETAPAPSQTAASDSSSSKTNTPKIPKWMKLGHSRQISFRRMAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCU8</accession>
    <name>A0A2R6PCU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TACO1/YebC-like second and third domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCU8"/>
    <dbReference type="STRING" id="98765.A0A2R6PCU8"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="17888" checksum="4FD7B262A7630931" modified="2018-06-20" version="1">MAFGSVALIIECLTENPSRTAKFTRNVLAKHQAHVTPVAFLFQRKGAVRVAIQEGDDFDARLERLVDTALNAEAEDFEQDEPDEGSMEVEFICQPNALAKLTSAVTAPGVCEELVSNEYIYSPTDKVEPPSDEEAKETLARLLDELEEQTDTLRVWTNLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMS2</accession>
    <name>A0A2R6PMS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMS2"/>
    <dbReference type="STRING" id="98765.A0A2R6PMS2"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015351397" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR93712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="141" mass="14474" checksum="4EC6DC52C20813D7" modified="2018-06-20" version="1">MRTFATILAFAASAMAYSVTAPTNATGFSTSGQNTVSWSMVSTDAANFTIVLSNQQVNPPVQQILAALVVGTLGTIQVNPPSTGWPTGSGYQINLVANSQQLSSILAQSDQFSFHAPTSSSGSSSSLPTTSLVVPPTFSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMZ7</accession>
    <name>A0A2R6PMZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMZ7"/>
    <dbReference type="STRING" id="98765.A0A2R6PMZ7"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="12279" checksum="4E67848062471D4C" modified="2018-06-20" version="1">MTKALTKVIYKPSTQSSEEFTVIVNLEEYKKWKEGAFDVFHSTQGAQGILGKASNQQLDNIFGTHKDVDVVQQLLQKGTPQQSDGIRSSDFGGTNISIGSFGVDTKGKGLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVJ1</accession>
    <name>A0A2R6PVJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000430">
        <property type="protein sequence ID" value="PSR97718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVJ1"/>
    <dbReference type="OrthoDB" id="2800083at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42588" checksum="A1A963E11AB08959" modified="2018-06-20" version="1">MSLTYEYKDYCSSCASTPTTCALDGIGARLAQELLGRILIFIDYSGTKEKRDVGQLALTCRYWATKCQPAIFKRIWLRSGKEVDELLSLMASPLSRVSSYIKTLVLIQKQPSNAPWIHLVALRLVPKLSLDTEDPIDLSLSNVDGIRSIHDGLPRSYPSFSSHISQLHLKNAHFNSFADLLHLADEMPSLQNLECSGLTWPTAPDTPPVVPRQRGIPPHLRFVSMDACTDNSALVCVLTGRRRQARANTTASLNFGLHPEQQHTIHKLVCTCAEKDDPYSTSLEKVDSAYNMILVSLIRRGSLRRFYFILPSTTLAGPNSIMQVEIMAMFIENYETGESDKWNQTCEHLPHLQKLVLGFSSREDMTRFVREVAAQSWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7L0</accession>
    <name>A0A2R6Q7L0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000383">
        <property type="protein sequence ID" value="PSS03713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7L0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="167" mass="18484" checksum="010E92159E805C2B" modified="2018-06-20" version="1">MNNLKLQLQSLERVETSADPNPDPAASEQGTTDGQPSAFIITNRSSEAYIAVTTIIHYIRTLLISPTIDIDSRPILYAFFPGVGRSLGPYIIHKFASLLRAVPIQSIRLKFTIPGEYADNGIRLAVGVHVRCTQPGANVRFVLVFTFDLVCDCKCGKRCSKQRWFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBF3</accession>
    <name>A0A2R6QBF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBF3"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54292" checksum="84E91DFCDF7CAB13" modified="2018-06-20" version="1">MSDVLETGHTPYLPIEITDTIIDLLQTDSKAILSSCTLVSRSWLPRSRLHLFTRVQVLELKTRFEPFIELLTQAGGPRLDPPISTTIKRLRLDASGGAGKKDILFNTPAPLTMVMLKMLLSNLPNLLDLDIHGVKLTWLEPGPPDTGDVIAIPDLIHLNSLTLDSFTTSSKDPSDFISSLSLFSSIDVLRISDVFHIDIPEDPAAIAAHPTLVMTNPYFPSHLEISSIEVRDDDCTPFLLALLQKTASVETINKLGVVCRTRVHADALGSFLDNVGAKIRKISVDIVMLFQEPLSPTVVDALHIPACTALTHLNLRISLILDLRNRLNTRMFIAASRLIACASRTVQTVVLNILLGGSYVGVNKFKSLIQTMTTEFKWLQSVIKQKGSRLCIRWNGLERMVKRVEKRERVEDQLCGLVRSHLLELDADGMLTFGGDVEDLYCHAHVLSKSERARQFDFMAMIQRIVSDDFLIGSGVRTNRRRRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QET5</accession>
    <name>A0A2R6QET5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QET5"/>
    <dbReference type="STRING" id="98765.A0A2R6QET5"/>
    <dbReference type="OrthoDB" id="3358078at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1227" mass="132562" checksum="F4755DA076E10465" modified="2018-06-20" version="1">MSHACRDLLPTFILFSSPPTLPSPLTATRSSSSSSTPYPMPPRPSFTHKQRPLSAIYIGSLGSTSTASPPDLPRLPEPPDSNPGSPSGLPSPPATNSTGSGSNGDDSTNSGSVRKPRPFSTSDMYNGSRNWSPADSRNGGSSRTNFSDDEDDQNNRDIDEDDTARLNLLRRRSAARPAPADNMSALQRVKSLTERNRMVLDKLSSISRHGSPVPGSSAKAPTRSPFSPPNAPSSSTSAATSSRISTPSRLSSSRARPLSLQTQSQLPSTSSKLPEPAHSGSETERESTHTHTYTHSYSSSDSLSGTPTSAYAPPESIRPRRISAPSSPTKSSRRNEETARDPSPGPSRTPRKRASMAVSASDVRRDAGDEDEDRGALDEDEDRGALDERDVTAAALAAVASSRRSPSTASRRNPTRQPLPREFRELDRRSDGKKVSCFAIAASVVNNEMALQSEPSTPHHERFQSDRRSPSPSSSRRPPASTSTLPAPPTSIQRSPRRPTSTRYSTVRELTRKHQTRWLSEDLSASVDADAEDDVSGRSNVNPGSGRKQTQRFGSSESPFGPSGGRSLLGEGLRAAGLTKRRESNFKDGETGDVFSNGHEPYTPSNSFVIPPRRTRSTGASSVVNGQNGWEQQNQAGPSSRGIGESTRRETRTPAPQRNGVYATPTTRPGTSMAALHHETPSTVPPRSLRGYRSTYGLERQMSSSTVASEEVLDFPTPDHPHGRIQPSPFTPAHRSTAGESHSEHRKLMLDALSMFESHLSRLPPMGQTTTSTIPEVFHNSQTLVRSLDRLNDLLRGSTSRALEAQIEAEVEDLGGIKNGELVELWSSVGSEHREHLRLSDEIVRTMTQFLLGVGRVLREASAAPSARGVSIDEDFTRRPSPEVTSTGTTSDKRSSDGRQSRETRRSWDPRDSATSRALTRLASRERTSASGGSRPTSSTHPLTRSSAASSSEGRSIVDDNVERTYTPPTIRNSITLIPSSSNRRLYTPRDQRTASDPVTSPAGLTLMSSVDSQTTLHAYEPSPTPASRQGLQVHLRTRTLPPLAIPPSLPTLLSESLLNRDSTPGTDRSERRKFSTNSTATVRAEFPPVIKPPNTTTAVTTSPAEFGGNFSRTDSANSMRSNGVTFSRPSTISVSTLSGLQQQNSSQIIRQRSNSSTLEEPSPISVRSPMSGSETERPRTLGLRDRMSLDGPRPAIGSGSASRASTLTSRRERRRTITDIFAQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM37</accession>
    <name>A0A2R6QM37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000324">
        <property type="protein sequence ID" value="PSS10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM37"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="206" mass="22602" checksum="1F19DC7997D52AD8" modified="2018-06-20" version="1">MEFSQESEPSTPTLSGASQCHPSHIPPPEPDQSSFQQPFSLTAPWVVAELHPPYRPEEPYFDMTSVSRVSSLDSALTRGNDPPDIPKDPHFNIASASGVTFRLACPHLYGDDTPHSSSEPCFSIAPDADVLGLLTLLAHCDGPILEQQKTLTRAEVQCKLEEREPELELKVEDDEPISETQEAASPPHSGLKTYRSGPFDTYGCWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QMA6</accession>
    <name>A0A2R6QMA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pheromone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v3338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QMA6"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS11042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34325" checksum="73DAF3ACE52BEC96" modified="2018-06-20" version="1">MASLIEFVDSIVWHGNIGNPAPVWCDITTKFLIGAGVGIPAASLCINRRLYKIASVHVTSITRQAKRRAIFIDISIGMGIPIIVMTLHTIVQGHRFNVLEDIGCIPTTYLTPPAYPLVLMWPLLLGCISFIYATLTLVSFWRRRVEFAVVLKSNSSLTASRYFRLMLLSCIEMVCTVPLGAYSIYIDTAGVHVDAWISWADTHFDFWFIEFVPASVWQNNHNYVVAVELGRWLYPISGLLFFALFGFAEEAMRHYRVAFWWIARHFGIQPRVGNLSSVNIYNKSQHLNPNISIPTSQSPKGVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R106</accession>
    <name>A0A2R6R106_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000285">
        <property type="protein sequence ID" value="PSS18908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R106"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="5851" checksum="1F9E9D8DDF84B374" modified="2018-06-20" version="1">MSGMLTNAFPPKPTWSVDEIPDLSGQIIIVTGGNTIGKKNICLHTLARPYKGHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R798</accession>
    <name>A0A2R6R798_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000273">
        <property type="protein sequence ID" value="PSS22612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R798"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="157" mass="17679" checksum="1EFCBA50E3847986" modified="2018-06-20" version="1">MTTSLPCNNKTHCYDTDDLRDRFKQINSKGKETWAECRGKICINRYTFPHYTEQKQDPWAKTTDPNQIRLIVEKHGLSDELRREVEEELAHRTRPTQPKASSSSSTTTQPIASSSTTRAVPASTTPKPQTPRPTQIPIARSASDSGTPTQQPISQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7A6</accession>
    <name>A0A2R6R7A6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7A6"/>
    <dbReference type="STRING" id="98765.A0A2R6R7A6"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="3">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS22653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="272" mass="28134" checksum="F29715ED63D6E021" modified="2018-06-20" version="1">MAVAKKSSTAKSAAAKKSAPRAAPAHPTWIDMIKECIADHQEEARTGVSRPQIKKYVEEKYKLEFGNAQTTQLSKAITTGADKQIFVLPKGPSGRVKLAPKNVRPPSPEAKENKPASKAAKPAAAKSTATKAKSSTTAKVAPKAAPKTVAKAAPKKSAAKVVKEKASTKPAARKTASAKAPAVVKKVSAPKKEVVKKAPAKTTKKTAAPKKTTTASRRDSAKKAVTGTSAATKAKSAAKKPAAKKPAGKAAPSARSARVSNTDLLRSSSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7D1</accession>
    <name>A0A2R6R7D1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7D1"/>
    <dbReference type="OrthoDB" id="2794694at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="12308" checksum="2E86126375B26CEC" modified="2018-06-20" version="1">MIGLSAAVHYSWIAPSIARQRHQRAIKAHRERYYTYSPSDSPYLSSEKLEESPRQDENWDPLTTNSLYTGGQSDAELTPPPPIYTLQKSMRFSTGTQDGREAVWWFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7D3</accession>
    <name>A0A2R6R7D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000268">
        <property type="protein sequence ID" value="PSS22681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7D3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="593" mass="64750" checksum="5D6A78001AD9536B" modified="2018-06-20" version="1">MSSVPPHDIVLVQPGDWSDMLPDAPSHEHRCTPACCSTVERADSVRSILAHSKEELLEGLAFPAGLTVADVDPWPAYTNGFRHICDKGIELRMPATDGFPTQCPHCSSATYWHVGRRPELAGAWILNCKNHECRLFMMPDQIPPCPVHVQEIREARKRDMENQLPLFLQRMARRLQEGKRVASRPGTPMKIDSPYRNLAKAGRVMSPLKLESGSPSIAPGGKRMVSTRGSPFVTPKKSVLVNPVDYASSSEEELPSPTKLLAGLREESKNKNAKVQDTKPTTPVQQAESQDDTKGLDVEPEDTEGLKHSKKGKRRIGSTRDGTRKQKKKRPVDVIELPDGNVGENYKERRLGDVIVVLDSDEEMFWSGHDDKIWEAYAKAELEAINKVGGSSGAGPTSESSGPTAVIPQPTTIADATINGSSQSTTTADATTSGTSQSTIVGPTTVSETSSPKVAVGHQPAADALDAASTSSSSSAGDFTIIDYPPKGELDLRVVVWSEYKAITIVEPNVPATFRFTDLRTTCEIIQATSNTVLKIWSESQCDWVWRRCSDAIAMPKGRFALLVRRDAVLDIDRVQFMKEAARLMQGCRASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6REP9</accession>
    <name>A0A2R6REP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000262">
        <property type="protein sequence ID" value="PSS28487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6REP9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS28487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="11226" checksum="8EFB34CBEEBC575E" modified="2018-06-20" version="1">MRGYIPYAMPPSTVPTKLDCSNQRSAADSPAWEYGFGAMHYESSTDKTEWDIWAYYPPKFVGVMVHGLSSYTYYNARYDLYHWEWPIRGRKSLIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHN6</accession>
    <name>A0A2R6RHN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000260">
        <property type="protein sequence ID" value="PSS29550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHN6"/>
    <dbReference type="STRING" id="98765.A0A2R6RHN6"/>
    <dbReference type="OrthoDB" id="2753780at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS29550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="467" mass="52500" checksum="3512AB01E41A86C6" modified="2018-06-20" version="1">MLKVSNQAGLFSAVIATFAVESYKSLLPDDEDSSSQILLHISHQLNNLGSNSTQPPLSLPAFQPSASAVRVNILWFFSLALALVAASLSMLVKQWLREYVAIDCTSPQERIRVRHFRYAGLIRWRAFEIAAYLPVILHFALTLFFAGLVDFLRSLNSSVAWFITAFLRAWWSVSAVISFAPTFSSTCPYKIPVFQVALQEVRLALWNLWKLFPCRKRPILPKYYNSPGDERGVRRDQNFDIPAIITADKLVTDEDFMGWPLISCVQGYDVLRQAIGHRLQCKVSSLENPIDFGRRRSKFLGPLSTLALDTLGTALEDSATILEHRSVGLDTEDIEEVQKRILGKGPEFVREYLTLLSTPFAGAFSGIDDPEIAHRMIFAPQDILRHDEVNSTHLCRHILYALLDQDDSWLTTGAARTGTQDVLSALAAAIERRRRQGNLLPFDDPDAMTCGAFCAGTWSHLRQKIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHU1</accession>
    <name>A0A2R6RHU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHU1"/>
    <dbReference type="STRING" id="98765.A0A2R6RHU1"/>
    <dbReference type="OrthoDB" id="3258408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="187" mass="21835" checksum="4A410767D14BBA80" modified="2018-06-20" version="1">MEAFQAWRLKEEEEKVVEFVKGDTHASKAVPPRFKDHTKLVCARHTRSGRKKYVKKFPERVRKVPSRKMFLNILMKSGLPIFLSPNADVKYRERNNQRPPELAVEQQQRVSVTLQARQDLRQTLWLGPPPQGLPTYVPTILTTRRHQHLLSIMYNRRHFKRRLPCLLPTSPSCLKPILTSHRNAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHX9</accession>
    <name>A0A2R6RHX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHX9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6910" checksum="164B98F9B5DD5A74" modified="2018-06-20" version="1">MARRPKKRVKYQHDASSGAAESSNFGEDPILQVQGLPSMPLDILEEVSSDQYTLDDDRFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHZ6</accession>
    <name>A0A2R6RHZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v2790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHZ6"/>
    <dbReference type="STRING" id="98765.A0A2R6RHZ6"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="47"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="454"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS29642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="747" mass="83616" checksum="38338E466C0880D3" modified="2018-06-20" version="1">MYTRNAIERTLLSLWEGYDEMTHAANGPTVSLEEAQRIERETADHLRKHRKLSLIVDLDQTIVHATVDPTVGEWIAEGEAWEARHPNWNDSQETVAPQSEDEVNPNWEALKDVKKFRLGPEALGQPYLRGIKGKGKGGSVENEGCMYYIKPRPGWEGFLEAMATKYEMHVYTMGTRAYAEEVCAAIDPDGKIFGGRLLSRDESGSLTQKSLQRLFPCDQSMVVIIDDRADVWEWSPNLVKVIPYDFFVGIGDINSAFLPKLEPLTPTLPSGASRPGIAKPPAGPIPPETAVPDVDPISSPLHTEIIPDESVPPSAEEEELAVLRKSEILARNAVALDAQVEQRPLAKMQEELQEEEDAQEADLQEEASSNGDKPSDDTDIPRSTTPKSEKHVRKALLKNDDVELNRVQRLLEEVHQRYYDAYDHLHHDTMVRRKPKHRQPQQLLYDVRSIIPQLRQHTLEGTHLLFSSVIPLDTRPESTEIWRMAQAFGATCYTELNSRITHVVAAKRGTVKVDAARRQGGIKIVWLAWFTDSIALWQRQDETPYLIDPEPVVVVGPASPPSDTHQISSDPEPDADDWDDDRAVPGKSLALDEVDWDEVNDEVDAAMNESDEDDDDMKSTFQGSNASEDDWTDESNSVLSSASSTPRKKRKRLRSITPSDVSTNGHDDSLRSPLAKRKKMVANRSGTSKLKEAITADDLEDEEGSVDKRSAPASANGRDEDEEMEEDDDTGEDDDDFLARELGEDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI50</accession>
    <name>A0A2R6RI50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI50"/>
    <dbReference type="STRING" id="98765.A0A2R6RI50"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS29702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="14580" checksum="A0DDF1DCE4CF772C" modified="2018-06-20" version="1">MYYRNANCAVVVYDITQSSSLEKARSWIRELQRQADPSIVIALCGNKSDLAARRQVSEEEAKKYAEEEGLMWGETSAKSGDGVSEIFTEIAKRLPKIAPPSARAPGGRAAAARTGVDLNKQTNASGEQNEQCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIB0</accession>
    <name>A0A2R6RIB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v2886</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIB0"/>
    <dbReference type="STRING" id="98765.A0A2R6RIB0"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01404">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015303237" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="25"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="27"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSS29738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="311" mass="34233" checksum="BC15D0AF9C0C6F4A" modified="2018-06-20" version="1">MPQTLRLWPFMLLALCLLTSKTRAEDDPCTVRDGDRFYDLSPLKAKKDYVFRSPEGQEYMINVCSPVTTETWAMKVDDPDNVGGFTRGEHGDFSLGYSNTTLTVRDGHPAITMSNGSPCPTHVHMHAATTIQFKCDTSVFGAGEPVLIAQLPPPDSASCYFFFEWKTHVACPTQARGGGWGIIAILATIAGVLFLVYIAAGVLYNYFILDRRGVDVIPRYSLFSLKDTVQFFRRCVERVKDRSSGALHFGNGGGGWGRRDGSYSGLAGSREEEAGMLSGPPGFLDEDDEEDPEEHENNRPQGIDSSGVIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLU1</accession>
    <name>A0A2R6RLU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v2470</name>
        <name evidence="12" type="ORF">PHLCEN_2v6792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000662">
        <property type="protein sequence ID" value="PSR80210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000229">
        <property type="protein sequence ID" value="PSS30982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLU1"/>
    <dbReference type="STRING" id="98765.A0A2R6RLU1"/>
    <dbReference type="OrthoDB" id="2732867at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR80210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS30982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15456" checksum="317CE5AB743DA3F6" modified="2018-06-20" version="1">MARTKQTARKSTGGKAPRKQLAAKSAARKTAATATGGVKKPHRFRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEAAEAYLVSLFEDTNLAAIHAKRVTIQPKDLALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLW2</accession>
    <name>A0A2R6RLW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v2490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000230">
        <property type="protein sequence ID" value="PSS30965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLW2"/>
    <dbReference type="STRING" id="98765.A0A2R6RLW2"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="294"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS30965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="540" mass="60042" checksum="BEBBF1CF50075674" modified="2018-06-20" version="1">MEFTPGPAVHRVLCADCGTPIVPNSANLCVACLRNTVDITEGIPKQASVSFCRNCERFLSPPTSWSLARPESQELLAICLKKLKGLNKVRLTDAHFIWTEPHSKRLRVSLTIQKEVLTATILEQVFEIEYLVQHGQCPDCAKLAAKNTWKGLVQVRQKVPHKRTFLYLEQLILKHGAQKDTISIKEVRDGLDFFYSSRSHALKMVEFLAGVVPIRTASFKYTYSVEIIPICKDDLVCVPLKQARAMSNINPLTLCSRVGNSIHLLDPSTLQSCEITAPTYWRAPVDSLATVTDLVEFTVLDVEPSGVTRGKWVSADAQVALSGAFRSSGLKEDDGMMDHENSSLANQIFHTRTHLGGILQPGDSVLGYFLSNSNFNSEDFAALPSHRIPDVILVKKAYPNRRKKTKTRNWKLRSIAKEAGEEGETGAGRGVVGRMGGRDQKKVEEDYELFLRELEEDEEMRGAVNLYKAKSDLPGAGSGLAGGKTRRKAHFDMDVDEGHAPQQEPASTDTEEVEEPDFPEVKLDELLEDFDEMTLDEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM13</accession>
    <name>A0A2R6RM13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM13"/>
    <dbReference type="STRING" id="98765.A0A2R6RM13"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS31052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46596" checksum="532D0CA509D04DFF" modified="2018-06-20" version="1">MDSTSSVDKKVEREGSDHVYKPTIDTSDVDIAARLTAGKEISFTPEEAARLSINIFIWAVALLCHAASKNFGELLACRIFLGICEGAITPGFLIVTSMFYTRKEQSQRVGYWFLMNGAAIIMLGLIAFGVLHITSDSLMPWQWLMIITGIITLIVSVLFWFYFPDSPATARFLTPEERIIAVERIKVNQAGVENKHFKLDQCLSNQRQIIVAGFGFTVGQTTLLGCVDGAVEIIVIFCTVTSATYWKNGRAYSGALAYSVAILGSILVNALPNHRVGLLFCYWISVTSIAPFVVMLAWVAATTAGHTKRTTTNAIVMIGYAVGNAAGPQYWKAVYQPRNHIPWAILSACWFVTAILLLVTRAYLARENAKRDKEQHDSKYDDIYITDVKADGTKEEIKVDKEFLDLTDRQNRDFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RMD0</accession>
    <name>A0A2R6RMD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000217">
        <property type="protein sequence ID" value="PSS31125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RMD0"/>
    <dbReference type="STRING" id="98765.A0A2R6RMD0"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="8"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS31125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="453" mass="50823" checksum="E9CC3CCA0ABF2AAD" modified="2018-06-20" version="1">MASTSATSNTIHLLVLTHGMWGSPNHLDEMSRVYKELRGQEGSKAGPDGEHLHILVAQANREKGTYDGVDWGGERVAEEVMDEIKKLEDEGKKVTRFSVTGYSMGGLVARYLVGVLHQRKFFDTVTPVNFMTVATPHIGLIRYPTFRSSLFAYLGPRLLSRTGEQFYTVDEWSPSGRPLLAVMADPDRVFYQALNLFPHIRFYANAVNDTTVAYPSAAVEIDDPFADHEFNGIHIELDETYSPIIKSYISSDSPPPPPPKPRAFSKKWLKGMQPQIPPAFRLAFPYNVLVIVALPVLFPTLLTLIVVRLSLDSRSSRSRIKLLESDESYRERLANVIGHLEKQVEDAVLEYMDDPGDSETTTDLSETPNTAVSTTKPGKCEKKEHKVVKPQVTAVQKKMIKSLNTLPNLKKELVFIHPVMNSHAVIISRDVKRFKFHAEGEGVLRHLADNFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ27</accession>
    <name>A0A2R6RQ27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000195">
        <property type="protein sequence ID" value="PSS32140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ27"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="112" mass="12337" checksum="FE714476B353E947" modified="2018-06-20" version="1">MDAHPPTPSLLLQIPLLRIRPRRTPTDLLSPRPDLHDDVHHILAVPHGRLLPRELPPRPPLEPSEAGKPVCAQVARGLDDDRAQLSVHDQAACVTDRRVDEDSGSLHGGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ90</accession>
    <name>A0A2R6RQ90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ90"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ90"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="14896" checksum="EE3823DC8E634A68" modified="2018-06-20" version="1">MEENWRLTVETKESRDNVAHLKTVDVSGMDEYKPVLLQRFFVCGGLMIQLVALAGLLFTHWIADSLTLWKSPSASDSDLRLWTAATYYSILSRMPPTLAYIYAVVAVLGGSTLFWSLGDLRAGNLMFDGGSICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVG9</accession>
    <name>A0A2R6RVG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVG9"/>
    <dbReference type="STRING" id="98765.A0A2R6RVG9"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30522" checksum="06FC2EB5C7186E67" modified="2018-06-20" version="1">MWFPYIITNGEVDLFSSGALSERILDILRTSEIEFLDLTASLAEEDGLNFKARDMLHVFAKPNSFLFLSEINLNDVRLYDADLMHIHRLPRLGCLSLNNTGISNEGIFLLIPLKRCLVDLDIANNSLIDDDSISAILMLIKLQFIGLYGTAITMDGLRRIASHLKQTRRTMEVDVPEDCEEYIRNHARTELPQQYWLVPASPLISDPTEALRLSSQALEQNLAAFAEFDQELLCDGSKTNMVKRLQDILETRRNDLLVRELVWQDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVT7</accession>
    <name>A0A2R6RVT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000151">
        <property type="protein sequence ID" value="PSS34129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVT7"/>
    <dbReference type="STRING" id="98765.A0A2R6RVT7"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS34129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="102" mass="11406" checksum="10F04172AC757A7D" modified="2018-06-20" version="1">MAHSLSDDCTPLKREYDSCFNAWFEGYLEPAVAATPAERLQHAQGKAEEYERNCGAIWTQYRSCVQKAVKDKGLDTLLQQAREENPLNEPPSIRASEGTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVU8</accession>
    <name>A0A2R6RVU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000151">
        <property type="protein sequence ID" value="PSS34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVU8"/>
    <dbReference type="STRING" id="98765.A0A2R6RVU8"/>
    <dbReference type="OrthoDB" id="2800983at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21776" checksum="55DA7A7760D70474" modified="2018-06-20" version="1">MVLAHLVPYLSDPAGLRAYPGPSLAKLSKFWLARIAYHGRVNASVYEAHEKYGTFVRISPIEVSIVHPEALHQIYGHTTGTTKSDLYSAFTQFGGTPSVFGTRDRTEHARKRKIMAHIFSLKSVVEFEPIIHSYQRVLVQKWDRICEAGVRGNGGVEGSCVWRAGNERAWFDCMRWFNYLAFDIIGRLFLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVV7</accession>
    <name>A0A2R6RVV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000150">
        <property type="protein sequence ID" value="PSS34135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVV7"/>
    <dbReference type="STRING" id="98765.A0A2R6RVV7"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015314788" description="Integral membrane protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="32"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="157"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS34135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37156" checksum="F9E64AB0B783DCDB" modified="2018-06-20" version="1" fragment="single">MTLWTMNKALSPSSALLFKLALVLPVAAHEHHNELSEEQTNSPVDSILWIHIFLQGLVWGVLFPTGMVLGLSRSRWHVPLQSCGIAFTLGGYILGHSHGGRSFLAGAHGTMANIMFAPIILQLLLGIYLKLHIHEESVRPWAVRVHGVVGKSYPVLGWTQMLFGAITFGGYCRGDNLGQCLAHYIMGTGFIAYGVIMAIMLLVGEAWIRRSGRSPEWWDSWVILLWGIVNTFTEHRGSGWSVKDMQHTIIITGWAFSEHAQALMISTRVHAIFGYTLMLAGIARIIEVSFITPKFTPITEPPAADDNHSEHTLADSPSSATGLYQAVRAFRHLPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3N3</accession>
    <name>A0A2R6S3N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3N3"/>
    <dbReference type="STRING" id="98765.A0A2R6S3N3"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10587" checksum="D26DEDF9CEEE503B" modified="2018-06-20" version="1">MIGAGLTQYEADVRMVILFSKLTDYIVDQMIMEGFRKELVKFDLERVLPAWDGLVAKQQAALEALGVPTMFPSTDGRDREVLTFNTGFPEIESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S433</accession>
    <name>A0A2R6S433_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PIN-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S433"/>
    <dbReference type="STRING" id="98765.A0A2R6S433"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35443" checksum="4D20DB212402C27D" modified="2018-06-20" version="1">MIAWDFAGPEVEDEEMREVIRFKRRTVLQIWKKMPTIARRRLDVQALEEDDRYSDETEGKQLPYKTVLSGTRFDEECPLPNTAPGPLSTTSGNHKDSTGTPEDTTPIITVLPSETIVTTSRISYTAHVDTSVPHITSPAPTITHVDTVTQVEPHALRTDNTHAKPVRFDEASSSEPVTDKPTFWKRTFKRARIFLVSLSSPPSLSIIVAFPVALITPLKGLFVTLPNSPIPNAPDGQPPLAFIMDTANFIGAASVPLGLICLGAALARLKVPMSLTAWKAMPVGSISALAIAKIVVSPILGVIICQGLTSAGVIDKNDKVLRFVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S499</accession>
    <name>A0A2R6S499_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S499"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="14582" checksum="93A36E7600229DCB" modified="2018-06-20" version="1">MSRRAFPNWGRARNVDRSQTNREYDNLAATSPEETISKLRSFHRGKNPERTNVAASIVQLFDSLAQRNEFAFEEIIHQYVMFGLHEFLLDIAMNQKIYPVRSNHNLEARLLLRSTLVISHSLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4D1</accession>
    <name>A0A2R6S4D1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4D1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4D1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="749"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="100"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="332"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="621"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="939"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS37122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130405" checksum="DBFF6BC51E9EDB8D" modified="2018-06-20" version="1">MITRIQGIVTQVILDHALRIRLKADVPESSDKKDATAASTPDTISIVDEGETSTLAEDQRSSDGDDRSTTAASGSAGAPTKDSGSIKDVGTKPSEKKEGNMIGKINNLVTTDLSTFEGGQNFLLLLFFTPFQIVLSVVFLYAILGWSVLVGVGVMLALLFLPGMITKLSHGVQVEKMKRSDARVQTVTEALGGVIRTVKLFGWEQKMSERIDAQRQGELKAIRKTKFLWLATSILSNLIPMATMVVTFTVYTLIMKKELTASRVFSSVAVFETLQNHFKGTAYTIPIVVQAKVAFDRINDFLLKTELLDAFSATEGTTALSPDSSSPDVIGIRAATFTWDNSPTSGTETPGSKKRNFKLCINDELMFKRGHINLVIGQTGSGKTSLLMALLGEMHYIPMGPGSMFSLPRGGGVAYHAQESWVMNETIRNNILFGSPYDEERYKKVIEQCALERDLSLFDAGDETEVGEKGITLSPLPPPGAQVLAALDVHTAQWIVDKCFQGDLIQGRTVILVTHNVALATPIAEYVVCLSPDGGVLSTGSLSSALAKDKKLSAEVAKESKQLEEADQQITEPKPNVAAQNSDGKLVVAEEISVGHVGWTALKLLFSNTSSGTAGLVVFWVVYFGALFFSKLAITTESWVLALWARQYEIHMGDPSEVSVSRYLSLYVIIFVFSLITSAISFTVFVFGTVRASRVIHKILIETLLRSTLRWLDKTPSSRIITRCTQDIAAIDANVVGFFNNLVHMTFDILLKFCAVIIMSPIFTLPGILMGVVGGWLGHLYMKAQLSVKRELSNAKSPVLGHIGAAIAGLVSIRAYGSEEAFRQELFARINRFTRVQRTFWDLNRWISVRGELLAGSFSTALSAYLVYGQRSDAASTGFSLTMAVGFSSMVLWWVRNFNEFEVQGNSLERIHQYLVIDQEPKPTPEGVPPASWPTSGDLRVENLSARYSEDGPKVLEDISFHVKSGERVGIVGRTGSGKSSLTLALLRCILTEGTVYYDGLATDKINLDVLRSHITIIPQVPELLSGTLRENIDPFSQYEDAVLNDALRSAGLFSLQSETDEGRLTLDSDISSGGSNLSVGQRQIIALARAIVRQSKLLILDEATSAIDYETDSIIQESLRKEVAKDVTLLTVAHRLQTIMDSDKIMVLDAGRIVEFGKPAELLDNEKSFLRSLVDASGDKEKLFAMAAGGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4G9</accession>
    <name>A0A2R6S4G9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4G9"/>
    <dbReference type="STRING" id="98765.A0A2R6S4G9"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="155" mass="17381" checksum="95BC4351FD403EC4" modified="2018-06-20" version="1">MLSDEQQFVLDMVKQKRNVFFTGSAGTGKSTLLKEIIGWCTKEAKGNTTKFAVTASTGIAGVNIGGSTLHSWAGIGLGKEPVKQLLDVMWRQYWIMKDKEKERRRRLGIPEDLADEDNSDEHREDALTVVGRWKLVETLIIDESEFPSTNESHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4T1</accession>
    <name>A0A2R6S4T1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4T1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4T1"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="14367" checksum="1C0889121373F948" modified="2018-06-20" version="1">MAAVYSPTLSSLHAQALRQHAAQLSLPQRTRPPSSRQRFVAELSQCLYDFVVQLLPTPEELGVKEDVRKLLERLIRSIEPESRLLSFGSTANGFSLRNSDMDLCCLIDSEERLAASDLVTMVGDFEGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5H1</accession>
    <name>A0A2R6S5H1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000038">
        <property type="protein sequence ID" value="PSS37537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5H1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="386" mass="41756" checksum="C51714B4A63B6B93" modified="2018-06-20" version="1">MFHSSPSAKSSVPQSHGVKLLGQHLFQNIVARGDQYKCSAWDALFAAKSEVGEDTFLDLQVVHDALSIDREELAEVIDHTVPLSLEWVSRAKSYKSQAKDFLTAVQRTLQQGRPQQKAPPTLTQPPTTIQISKGSALEHCHRDVVECTNCLVQFTQMPQGTTHHVTSCPCSIRRTLISNEPVLGTAETETKYNDATHDSPPLVPTMRELLMSVTAPLDKETKQAIGGLMKSAGCDMDGDFFMNELLRRHSRYNASLSSTPRGPALDVSQSQHVRSKSVKSTASTTSSSESDASSESASSSSSASPSRAQDKTPPAPRSPLRLKIKASGSVPLSKELVRLLEALCPNEAYNRVGKEAGVSLDNLSETSSILVSPYGPSRSTTLDSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5M2</accession>
    <name>A0A2R6S5M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5M2"/>
    <dbReference type="STRING" id="98765.A0A2R6S5M2"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="286" mass="31181" checksum="7F5DDBE7CDD1C5C1" modified="2018-06-20" version="1">MAPPPIQLFLTTIASQPALRQRQEYLLRILQVKKIPFTSYDLASDEDAKRLWKRKAPSDKQQLPGILIGGKFPGGFNEFEEAVEFDELDIFLRRNEDYKPPEDERPGLEAKPIGVPGAYSPLQMFPKHAPSRSPSPSPLKLKEKEKGEIDASEHLGAFGLEGVRVSADDLRALIEELGLGGDAAKDLVKDLGGDSEPATPEKKDSGSAPASADKEGESAVVPEILVQPEGESDAKEKAEEVKAEEVNVEEVKVEEITAEEVKSEEVKPEEAKVEEVKAGEASSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5V6</accession>
    <name>A0A2R6S5V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5V6"/>
    <dbReference type="STRING" id="98765.A0A2R6S5V6"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS37642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="9723" checksum="7F41C1A81A131232" modified="2018-06-20" version="1">MASTFFTWLRSPAAREYFLTWRVIPRNYLLFACHATNATAQTVQGARYINYWHMGGKEKKDKQKGPVTQAIEATREEAEKVAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5X1</accession>
    <name>A0A2R6S5X1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5X1"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015355365" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7424" checksum="D1A98C3A270D14B0" modified="2018-06-20" version="1">MPRIIFIVSISLIIYISFDEFPRANSSKWWSAQSNVNPPYVPLDERGFRRALDQFSGADMRMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S671</accession>
    <name>A0A2R6S671_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000031">
        <property type="protein sequence ID" value="PSS37788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S671"/>
    <dbReference type="STRING" id="98765.A0A2R6S671"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="269" mass="30127" checksum="4B294936DB15F27A" modified="2018-06-20" version="1">MSKGTQPQLGAPRKRMVMRCMALGALFTVAICVWSYLRGQSSKVWQESGIGYDTAKVEITSQSPSPKNCPSALPPPAMPPVDVNLWASLTPTEIMIVNEWLFEPSRDLNLTAGDHAVLSDNLVFRIEAYRPSKASALAYLSSPSWENLPDRFAKVTIHHGARNDQDGGPVIREYLVGPLDVREDMTIKRLTEIYHREEIPFNARAYTKPAELAPFLASIMTPLAEVTLVRNLLVRFVVSLLISTVYRIYSEGYFLVSQMILWHPQVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6B2</accession>
    <name>A0A2R6S6B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000030">
        <property type="protein sequence ID" value="PSS37795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6B2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6697" checksum="CEF24BE6E5F0609E" modified="2018-06-20" version="1">MTETPRLKELGAKAAAKHAVLNVYEIRWRDSITQDGYHLGISTKVGHQANLRTRGLPGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6D0</accession>
    <name>A0A2R6S6D0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF747-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6D0"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="73321" checksum="10825982D3A7D57D" modified="2018-06-20" version="1">MPTAANSHSPRRKRIGRYFSASGSRWSGTGTSTPPNIRKRRDSSTSSTGRLTFSAGFASERSDAEPFEDTASFTSQAERKTYPVLPPLDRPPLTYASLPPTPILSSPHSRDDSPPLTSPPYTTTFDRQKPSDLGNTPPFSLWDYLREELLATDFDSHQELKWERIMLFGFTVCFDSFLYNFTILPIRFVLASGRLLLNTITPRSPALPPSQKADILRTLLLIISIVILSPLTDASKIYHSIRGQDTIKLYVIFNALEIADRLCGSIGQDIIDCLFSRSTLEVISHRKRPTSYTLRPLFYFILALVYTVSHTLVMIYQMISLNVAVNSYDHALLTLLVSNQFVEIKGSVFKKFEKDNLFQITCADIVERFTLALMLVVVAFRNLIELSGSSFNFSEGFALPKSFGWFRGNNVLWTISYPVLSVMISEMLVDWLKHAFIAKFNHIRPSVYERYTDVLCRDLASGSAVGRRGARKHTYVDQSPLVARRLGFASLPLAVLAILIGSQSINLLIAMHTDDSSPWTWSFSEMSNEELINIGKWVALGTLIWACVLVIKLIMGVNLLSYATRRRSGMEAREAGDVVNDFGRNPIGEAKEEQKYNRDLKTLLDHNRDDAEPVAEIGERKSEVAGGGEGGGKRKRLPLEEITRYTMVKRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6U5</accession>
    <name>A0A2R6S6U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6U5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031755">
        <property type="entry name" value="Inhibitor_I66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16850">
        <property type="entry name" value="Inhibitor_I66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6187" checksum="CBEA0EECF4CFB44D" modified="2018-06-20" version="1">MTKLRTGNYIITNKADGQTLAIGRGADDKSLLPKKVVSLPPSIEAPVVRQNILRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S781</accession>
    <name>A0A2R6S781_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phospholipase D</fullName>
            <ecNumber evidence="1">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v82</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S781"/>
    <dbReference type="STRING" id="98765.A0A2R6S781"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF186">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="671"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS38102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="807" mass="92585" checksum="3695E1087590C923" modified="2018-06-20" version="1">MSNFLEKIVERTSEGIHHARETAIGILNPNRRHDDPEEKHNDMIRAEINAGHRFDSFADERSQNFVKWHVDGHDYMYALSEMLDSAREAIFILDWWLTPELYLRRPPAFNEQWRLDRILKRKAEQGVKVYVVVYKEVTQTMSMSSSHTKHALEDLHPNIACMRHPDHIGSKDDVEFWSHHEKVVVVDNHRACIGGLDLCFGRWDTHTHPLADVHPTNFANTLFPGQDYNNARVLDFQDVSQYANQGLSVLDVPRMPWHDVHMTLCGSVVLDIVQHFVERWNEVKRRKVLTVFVYGPQLTISGRDRRYDWLALPHDIEASPNEAVVRHPHREQWHAMGRRFKQRFHRQYPEAYPEEEEDPIAISSTINEGPVKNLIAQALVQRIIQAGQSGQKFKVVVVIPEVPGFAGNIKNESSVKIIMAAQYRTINRGGHSIYEEIRKAGFEPMDYIRFYHLRAYDRINAPYPSFIAQIEETSGVKFQQAMVALARQWVGQEDGPSQPQTVSIVLPVENDNNAADVAGTKNDTKTETYPLPRSVDEAREIIERFEHGADNLRSDEDVSDNVVQHMLNDRTSLLDEKWLGTEEEERNAYVSELLYIHSKVMIVDDRRVIMGSANINDRSQKGDGDSEIALVVEDDDLVETQMDGQKYMASRFASSLRRKLYKEHLGLIPPQLCEGPNEEPTSFMRPAPLPNDDETSQAEDEAVADPLSDSTDALWNGTAKKNREIFTEIFRPVPTNLIRNWDAYANYVPKTKTDHVAPDVPLSRIKDRLSQVKGALVECPLDFLIDQHDFVEGPEWSGFDPTLPIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7D4</accession>
    <name>A0A2R6S7D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v79</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7D4"/>
    <dbReference type="STRING" id="98765.A0A2R6S7D4"/>
    <dbReference type="OrthoDB" id="2339190at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015305165" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="7398" checksum="CFB874CDD34A5E18" modified="2018-06-20" version="1">MLFQTALFSALVGLVAGAAQDVWAPPITSPTAASVWPIGSAQNVTWDASHPPSEVTNPIGTIVLSKGGVLDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDU2</accession>
    <name>A0A2R6NDU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDU2"/>
    <dbReference type="STRING" id="98765.A0A2R6NDU2"/>
    <dbReference type="OrthoDB" id="47488at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04486">
        <property type="entry name" value="YhcR_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015341751" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="314"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="644" mass="69457" checksum="EE8F89B2042727A6" modified="2018-06-20" version="1">MFAARHWAVWLGQWTAIVSSVTAVNITDIQGPAFQSPLTGQAAQNVAGIVTAKASTGFYIQGPSVSDVRASSGLYVYSTSSKVLNAVVVGDSVTLSGKVQEFRSSSDPTYLYGTELGSPTNITILSHNNTVKPLVLGVDRSPPTQQLSALDVGRDGFLSVPNNQSRIDVVNATMQPNKYGVDFWSSLEGQLVTVPKPVSIGFENSYGEFWVRGDWKATGVNTRGGLTLAFGPDGIPDANPETIIIGSPLDGTQNPKMCVGKTLTDITGVVQYQFGFYYILPLTAPTVLSTPDPTVSPTKLKSSSNTCVLTIGDYNVDNMGPESSHLPSVAAHIGDYLLTPDIMFLQEIQDNSGETDDGTVSADVTLSTLTAAIANISAVTYNYTEVISENDQDGGVPGGNIRPAYLYREEKVSLVKGSPVGGPLNATKPVFGHDGKLTLRHQISFNPGRIDPINVAWNVSRKPLVAAWETTDGHRFFTINVHDASKSDDSSSIQGDPRPPINSDVDQRTSQVEVIAVSDFPFRILQNNMSLGDAQTFVKSILKLDPLASIIIAGDFNEFIQTRSVFAAFNGLVFEADELAGIDPVERYTYVFDQSMEQLDHIFLSPVVSLRGVEVEHVHVNSWAPDYDSRTSDHDPSVARVRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NET6</accession>
    <name>A0A2R6NET6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001305">
        <property type="protein sequence ID" value="PSR70890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NET6"/>
    <dbReference type="STRING" id="98765.A0A2R6NET6"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="248" mass="27850" checksum="4CAA0679DE03E81F" modified="2018-06-20" version="1">MDASNPIIFYDIASGPPVIPYAPNPWKTRYALNFKGVHYQTVWVELPDVASVRNKLGVAPVRAHKDGSSFYTLPIIKDPSTGDIIGDSFEIALYLDRTYTNAPLLFPPSTIGLQAAFNVQVDAIFTRFVILCAHGLPFNSETAEQSKAAFLWRAGKTDWEDMTVRGDERAKTLEAFKEALGELAKFYRCEDGPFLEGKNASYADLIVGGWLAFMKVTLKLKEWEGLRTWHDGRWGKLHLALEKYAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFP2</accession>
    <name>A0A2R6NFP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFP2"/>
    <dbReference type="STRING" id="98765.A0A2R6NFP2"/>
    <dbReference type="OrthoDB" id="2758323at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="305" mass="30793" checksum="DDA9C91555CB155A" modified="2018-06-20" version="1">MTLLHPHTAGPPTCVITESCPLPGSDSSVIPSLVTSAGTKSTTGNVELSSPGDGPSTSSGLPSYTSSAVSTSSVSGSIDPVPSSVSGSIDPVPSSVSGSIDPVPSSSSSPSKPTSVAILTSLSSPSPNGSAAISSTSPPPLIPNGATSVLPGSASSSPLPNGIVSVLPGPASTASTAVSANHHSNHAGAIAGGIIGGLIFLGLIILALFYRRALLKRLYRNRTAPSAEFINHPEFIHTRQNTNNTLLRGVSPYVDEEQPPPFTPGSFNDPIVEKVTATAAAQREMFDPFMDYEDRGASAAAGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFU6</accession>
    <name>A0A2R6NFU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFU6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6292" checksum="A46E93E29BF97B3A" modified="2018-06-20" version="1">MIAVGPGAGIPRVPEPRLGQSCLGMFASHAGMQQAPRHADKLFTRRTHRTLKIRQGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG03</accession>
    <name>A0A2R6NG03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG03"/>
    <dbReference type="STRING" id="98765.A0A2R6NG03"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="214" mass="23308" checksum="4B30694C25681611" modified="2018-06-20" version="1">MSSDGYFDDELDSAFLQAVDAIEAAHTSPQPKRPLAVPLPRSLPSEVIHVDDSYDFDSFDVDDDGLAMIDQICNDALSKDKQYTAPPRNSNGISSSSRPTKATVQTTLFGGVAKQPTQGGSSGASSSKSTLQRRTSSSNNVFTGRLQKTKKWDHTAFAKTGWKKAKSAKEKGKATSFQDWDAGEEDDDEEEPVEFEQFPAPFISIGCVCRVLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG33</accession>
    <name>A0A2R6NG33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001288">
        <property type="protein sequence ID" value="PSR71345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG33"/>
    <dbReference type="STRING" id="98765.A0A2R6NG33"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="22809" checksum="7854D2E6B098016D" modified="2018-06-20" version="1">MIDAETEKRGRSAEPDEKQMQKRRDWKLERMVARQTAEPTGSAINQTFGCDLLDELINYALQFSLPWDGWEGHADGGDFDPVQGVHPLEIPAYVLLREFILGNNQTGLVTNSSGTVSIVGGESPSLAADVFPGQSGIYMGQGATQSTYTFPSATIAAWESFIATAISTSATGTNPAGGAPPSPSTTGSSGSKASGTVHAGVSAMLAALCLENDGILAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGK8</accession>
    <name>A0A2R6NGK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alkyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001286">
        <property type="protein sequence ID" value="PSR71378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGK8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGK8"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20634" checksum="C9FE1CF682EBCE48" modified="2018-06-20" version="1">MPVGNIKQSARDTLTVSLRFEGYAVRHIFYVVELPVLNRKLQVLEICMHLNIHCVSAYAFAIENFKRSPEEVDALMTLAEEKLVEIAQHGELLDEYGVRLNVLGKTELLPSRVQVAIRKAEEMTRHNDREITEKDLDAHMMTSMVGSPPVDILVRTSGVKRLSDYLVWQSGQLLDSLKRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGR8</accession>
    <name>A0A2R6NGR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGR8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGR8"/>
    <dbReference type="OrthoDB" id="3356102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015356340" evidence="2">
        <location>
            <begin position="20"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="390" mass="40149" checksum="68A982DB43996175" modified="2018-06-20" version="1">MFRKLTLVSLLHLATSALSSPCVTFDASFNLLAFGLNGKDWNAGTQDSWTSGSAADITATGRPPFDGANTTCYLAQFFNAVYVMNGDASNPSAVYIYDAGAKSWSTQSVTTGTFDPSSFNAILDHDTNVFYALSKGEVFFLDLGSLKVANTTALSWVDVGKSPYPATYEPVMALAQNHIHFLDVPGTPAGDADIFVIHFSFFQPDPQSYPLPDGSAFPATHGQASSFFQESAVQQEFAFIPDDGSNTYVINVETNTTQSLAGPSTKDAKATYAASITALVQLDSTGAVSFLPYAQGDASTNAQAKWTSVANVAAVAPPGSSSSSSNSSASGSNSPSKSSASGVKTGASGSSPTQSAGASQQSGGALSTSSGLTGFAMIVAGMLSVLGMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHA6</accession>
    <name>A0A2R6NHA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-hydroxyacyl-CoA dehydrogenase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHA6"/>
    <dbReference type="STRING" id="98765.A0A2R6NHA6"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="20904" checksum="D3FDC2425484F4E6" modified="2018-06-20" version="1">MAAVTHGIRKLGVLGAGQMGVGIAYVAALRARVPVLLHDRSETQIKKGLAFMDKLLEKDTAKGKITSLEGKEARDRITVISPEAGLSGMRDVDMVVEAVSEKLELKQSIFRELSAKLNPDAILASNTSSISITKIAAATIPEGETGSSAEGRKSASRVVGECLISSLYVYMESLLPEMMGCLHAYGRKLVKGSPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHB5</accession>
    <name>A0A2R6NHB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHB5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11255" checksum="E3CEE427ADC20BA8" modified="2018-06-20" version="1">MVYCTAAGRESPGSKEKANGITPHKLKERGPRMEAFGRIGPHRVPDNSASSPSRPLQMFPLWPRWFLHVLDEHIWGVGRRGSSICNLDRDSSGGGGGTSAKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIJ8</accession>
    <name>A0A2R6NIJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIJ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NIJ8"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="250" mass="27587" checksum="14FE310168046C56" modified="2018-06-20" version="1">MAYIGLEVGGICQQGSGELWVRNSSAKRNSNCSEYVNRTAIGLRVKDGIVLAVEKIIHSKLLVPGANRRIQSVDRHIGMATSGFLADGRHLGNRARDEASNFRETFRMPPPLKDVVSRLSMYVQAYTLYSSVRPFGVSTIIGSVDKDGPQLYIIEPSGIAYGYHGAAVGKGRQLAKTEIEKLKLVEMSSREAVIEAARIIYLVHDDAKEKDFELEMSWIGDETNGLHLPVPKELHAEAEEKAKSALETFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIS8</accession>
    <name>A0A2R6NIS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIS8"/>
    <dbReference type="STRING" id="98765.A0A2R6NIS8"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044716">
        <property type="entry name" value="LEUNIG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL COREPRESSOR LEUNIG ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44376">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF FILAMENTOUS GROWTH FLO8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="521" mass="54783" checksum="BEC10B76933196B5" modified="2018-06-20" version="1">MSTGPPSTSSAPPNLNGAPSPQPPWDGDRMFNIYIIDYCHKRGYKQTAKTLLEEAGLPDDSHPPINARQGLLFEWWSVFWVLFSAKNSGSGNGNDDAVLYAQHQAQQAAHRQAQAIRASSPSAMNRPVNGINSGGPLTNGAAVPLPQLGQSSLMNGPPTPMAYPGPLPVNGLRPGPTSNGPVIGTPAQQGMQRPPMAPQRAPNGPQFHSPTMAHSPQNPGAGGLSQPTQPSGPLGSSQPLPRTSMLPPNGHQGLPNSGQTGGPQQASQSSYQALAPTSHPNSPAQNPMTAASPSLTARRLPGPSPNDMRQMTESNANDLFRIDSNKLGELKAEVGLRDKDLPSLTYEDKQRILHLARARGLISATPKPGMGQPNATPGPSNLNSSLQQRSQPGGLPQPPQGQQRSVKRSSTSPGDDNESSPPANKRLRPSPPGEHSQPPMAPMVSYTHHPQQGTPGGLNHQSNGIRMMPNMPMGVFPGPPMSSMNNNNHMNMSVGPNMGIPHGMNPSSMNAGMAQVSAGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ54</accession>
    <name>A0A2R6NJ54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v11870</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="4 13"/>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ54"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ54"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="15">
        <location>
            <begin position="81"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-glycerophosphate oxidase C-terminal" evidence="16">
        <location>
            <begin position="469"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR72278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="772" mass="85300" checksum="3A3DD5A1E1FD4032" modified="2018-06-20" version="1">MATLRRVLFSRRTLLIATGSTLVTAAGGYYYLNSGPTYPPSTKETRRPPPPWTPPSRIQMLDRLKASSKTDLAGGYSEEYDLLVVGGGATGSGVAVDAASRGLKVALVERDDFSSGTSSKSTKLVHGGVRYLQKAVMELDYEQYKLVKEALHERRIFLQTAPYLSAMLPIMLPIYKYWQVPYYWSGCKMYDILAGEENMESSYLMSKGKALEAFPMLKQDGLVGALVYYDGQHNDSRMNIALIMTAVQQGATVANYVEVTDLHKNSGTGKLYGARVHDRLTGDLWDIRAKAVINATGPFSDALLTMDNPSHTPIVQASSGIHITLPNYYSPRTMGLLDPATSDGRVIFFLPWQGNTIAGTTDSPAKVETQPQASEEEIRWVLEEVRRYLSPDIKVRRGDVLSAWSGLRPLVRNPNAASTEGLVRNHMIHVSDSGLVTIAGGKWTTYRAMAEETVDKAIEVFGLKARAGCVTEQLRLVGSDGWSRNMFIGLIQRYGLESEVAKHLSDNYGDRAWTVCELAQPTGNAWPLYGIRLSPDFPFIDAEVRYAAQYEYAQTAVDVIARRTRLSFLNAQSALQALPNIVDILAEELKWDRKRKEEEIENGIQFLLTMGLPPGLDPRAILGLKEESKSVFGRVKGFIGLGSTEQKRPASEMFYSRSQFEAGEVEELRQAFSSHAKAGLSAAPAGTVSPARVDKAELFDLVRHLPGFEGIRSKDYDYVLEEAGYSKQQDVDFDEFVEICAELREVVFTPRTSSAAKKERTAIPVEKSGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJJ1</accession>
    <name>A0A2R6NJJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001173">
        <property type="protein sequence ID" value="PSR72481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NJJ1"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="312" mass="36509" checksum="4555BAD637A1D8EC" modified="2018-06-20" version="1">MAGTLKLEALIAKASAQHAKLLGYEVRWRDRQRFLESKGYMLRPRYRPGWVPSWFMDKSRPLEEFEDYWDLPVSLCFGVSCVGLQSILKFREHLIDTTRLSDGKMVYVKHVQTGDLESTIAMMLSSSELLKDPRNHCVPILDYFQDEDNATISYMVMPFLHLTDSPPFKTVENIVDFIEQTIEGLVFIHEHGVAHRDCSEKNLMMDVHQLYPEGFHPVLEEFSPDGRTSARQLSRTNVRVKYYYVDFGISVYFPAHQHPKLAVGEYGRDQDVPELSVEVPYDPFKVDIFIIGNMYKRQLYNVRVLFYDKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJS0</accession>
    <name>A0A2R6NJS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001151">
        <property type="protein sequence ID" value="PSR72627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJS0"/>
    <dbReference type="OrthoDB" id="2754328at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="63372" checksum="83862E1F93058221" modified="2018-06-20" version="1">MSHASSSSSLDCTTKQALESLTFDIQQLRDMQEETNSRFTQAITLLQLRQTRLHNAEKIPLPEDIVRVIFEYVAIHEHDCRMSLGFSCWRSVLAISQTCAHWRFISLTNPLMWSRIDYTQLPLFLGSLFFTRSDQCALHIATKIASIPSDNDWIEPIFPRLKTLAIEFVNSKDLVTLIRQRVPLLETCFLKSSAQIQVPIFEGPFHNKHVSNIFGSEAPRLRNLCMSGIRMPWAPGQYVGLRSLHINTDGAMSINDQNILTIFRDSPLLEDLDLRHIQPLHWTSLPVDPTLIPLRSLRRLKLTMKPADQLRILSSIITPPTMDLLHITAINSAWAWIDEGYLIPFPADSRCLPPLHTMQSLCLDLRHPCISGCSKPGHPSMWFIAGTSYSEPGLERVFLRDLQVLRSVYSLASLTEFTLIGSVYNFIKGEDIVPLLKVAPNITSFALENVSSDIVDELANPSHALRAFFGNLTAFTLKHMLIQASTMLTILHPGPDALKKLVKLHFCSCNFSAETASLAREQLQSIRQMNIGDLIVENAKLVYPKQQRTRASSTRQTWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK17</accession>
    <name>A0A2R6NK17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001145">
        <property type="protein sequence ID" value="PSR72651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK17"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="6672" checksum="144E3DB616FF0ED2" modified="2018-06-20" version="1" fragment="single">MSSPSIKADTITKFTSSNYAEWNISFKSACRIAQCWGVVAGTTTKPTTGAAEIAAWETKNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK29</accession>
    <name>A0A2R6NK29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v11415</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK29"/>
    <dbReference type="STRING" id="98765.A0A2R6NK29"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="197"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="372"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="882"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="882"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR72720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="107435" checksum="29865EDC236729E6" modified="2018-06-20" version="1">MSGKFGDLIDQSASLRTLAPAAVGSQVALMSLISAFTIIIFNVLRPRNKIVYEPKVKYHVGDKQPPRISDSIFGWVSPLLHTKEPMLVDKIGLDAAVYLRFLRMMRHLFSSVALLTCAILIPVNVVYNLRHVPKTNRDALSFLTIRDVSGNLLYIHVAASYLINFLVMGFVWLNWRAVLRLRNEWFRSPEYVNSFYARTLMVMQVPKKYQSDEGIRAIFESVQVPYPTTSVHIGRKVGRLSELIELHNDTVKDLESVLVKYMKDGKIAKERPMKRLGGFMCFGGQKVDAIDFYTAKLQRTERAVEEYRNQIDTNKPENYGFASMASVPYAHIVGNMLRAKRIKGATITLAPNPKDIVWENLNKSKADIAQKKTTGWIFLCVVCFFNTIPLFFISILANLASLTSFVPFLQKWSSTSPGSFTFISGVLPPAVSALFGFFLPILMRWLSQYQGATTHSRLDRAVIARYFAFLVISQLVVFTLIGVMFNCVKEIVAQIGQHSNIHKILDNLDTLPGTINRTYIDQASYWLTYFPLRGFLVLFDLAQIINLAWISFKKHLFGRTPREIREWTQPPDFHSNILFMGTVGLVFAPLAPLVVVAAAIVFWLSSWVYKYQLMFVFVSRVETGGRLWNVVINRLLTSVILMQLLMVLTIGLQHNFKSLSWIATIPPILIIFGFKTYCNRTFNTAFSFYIPSADELQAAQVHSQRADNAGNRLEKRFGHPALHQELYTPMVHANMTSLLLDVYKGKIGNTQTKLGEYGGDQFDAHVVAGGIKIAGIEENALEYDPAMYQRDRGELDWDARSVSSANLLGPTKSEYGPADRMSPAPSKMMGYDRYLAQGPQPEIEMSRLNIDRVPLLTAQQNPGYFDPMGSRSNMSLLSTPGAQYSPHASPTLDSPTQIPAIPPMQPTQDYRQASLHRPYPSSNQSQGQAAMGYPPQPPQGQDMNMAGRGAFRGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKV4</accession>
    <name>A0A2R6NKV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKV4"/>
    <dbReference type="STRING" id="98765.A0A2R6NKV4"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="19740" checksum="36690F1676407C36" modified="2018-06-20" version="1">MKALNDALCLQGLSELSSLNVPIQPPSTWTSTGWLDDLNINDPKSTFARMDVSRGFLKADITVYDERTIPFRPLLYSVHAPVIPIPSSYPAYFKSRRPSAATAFSSVVTSSRTAPLFASYASLAEDCMHRHTDVIDKMGLEKDDIRQLKEDLWALEDGYKDDEQFEDTDIGEEAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLD6</accession>
    <name>A0A2R6NLD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLD6"/>
    <dbReference type="STRING" id="98765.A0A2R6NLD6"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="9">
        <location>
            <begin position="428"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="881" mass="99510" checksum="70683EAD8F19C7D8" modified="2018-06-20" version="1">MSSDASMLSDDDRPLRAKPGPSHTNGNGHIGMNGNGGADRSSSFSDDDEIPLSQTTRTKSEPMTPDVRNLKRKKVAAESSSEDELPLASSPMKGAKSAAVPMPGAVLATTVPTANGTNGKRKAAVKSKAIVDSESDDDVPIGKTKRPTNGKAKGKPAKKKAKKEESDDDFGIESEDEKPIAKKRVASSKGKRKQAEESDEDDEDDKPLKKPVAKKTPAKRVKKEEASGSETPQPKKRGGKVKKEEGGEDAKSGKKTKKEEEEEEIFRWWEQQDPNGDGSDKWQTLEHNGVYFPPPYEPLPSHVKMKYNGKSVDLPAAAEEVAGFYAALLESDHAKDQTFNKNFFTDFLTVLKKNPPRDGTKITKFELCDFRPMYEYFEEEKAKKKSMTAAEKKEAKAARDALEAPYTHCTLDGRKEKVGNFRVEPPGLFRGRGDHPKKGCLKFRVKPEDITINIGAKVPKPKPNVPGDWKAVTHDKTVTWLANWIENVNGNYKYVFLAAGSSLKGQSDMMKFEKARELKNHVDKIRADYTKDLRAKPSQIRQRATAMYFIDRLALRAGNEKGEDEADTVGCCSLRYEHVTLEPPNFLVFDFLGKDSIRYYNRVQVDAQVFKNIRVFKGDIKEGDDLFDRLETSHLNKHLSSYMKGLTAKVFRTYNASITFQQQLDEGTPEKGTVQEKLNAYNHANRMVAILCNHQRAVPKTHEQSMVKMREKLRGFKYERMKLRHALFGIDPKFKKKKQYAEDESDLDDDAVIEHEEQWKAREIEKAEKKFQKDNDKLAEEDKKPQPGSVLKDKIAEIESEFKRLKKERGTNKAELKRDKPTEKIEDAIEKLDDKIKTFKLQMEDRDAGKEVALGTRFDHGCVVQEARRAYQQNILEDPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLU4</accession>
    <name>A0A2R6NLU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v10792</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="MLYV02001080">
        <property type="protein sequence ID" value="PSR73357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLU4"/>
    <dbReference type="STRING" id="98765.A0A2R6NLU4"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR73357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="237" mass="26253" checksum="AF57B6EC71143C31" modified="2018-06-20" version="1">MTGLQNTHISVQGTIKFNPNIPYWSGNGFFIPFQTQITFWLLGGNNLVLDGGGTLDGQGQAWYDAFAKNSSLARPITLTLYQAKNVTVENLHMINSPEWVNLVNEGEQIVYRNLNISAVSTSENGAANTDGWDIYRSNNVIIENSMINNGDDCVSFKPKYSCFSLQFLFPLTISTTHRNIKMSNAQNGARIKAWAGQGVGSGIVKNITFLNFSETNVDNPVIIDQVSQLQEYKPFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM36</accession>
    <name>A0A2R6NM36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001082">
        <property type="protein sequence ID" value="PSR73339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM36"/>
    <dbReference type="STRING" id="98765.A0A2R6NM36"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="16779" checksum="F1152FC9AAA29585" modified="2018-06-20" version="1">MSTSLPSTSLFSSSTPDPKSPLTSSTTLPADGKNARSNVGPIVGGVIGGVGGVAILGAAFLLFLRHRRDSNKIAPSAVHHAVSQEAPWFPPIEKSHMSQTIPTQPQDFSMNLAKLYNPDDPSTFPGVLNTATAFAPPAGNNTLDGSFTVHNDSHYSGAPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM95</accession>
    <name>A0A2R6NM95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM95"/>
    <dbReference type="STRING" id="98765.A0A2R6NM95"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="165"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="585"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="734" mass="82468" checksum="A0B2CD0DC4CFFB67" modified="2018-06-20" version="1">MRNPDKAMAALTWQDILAEEPFEGQHWEGVYGLPSGNVVGSHSWGADSDGSTPSLSPWDDEDDTEQSSSSSEIELTDKVPDHLYESEPDTRTWGSQVASYNHRYEVEEMQARQYWRPDWRSPASLHKLFNIGDASTLGPAFRRLLGPGRVEGTVQDKWINEHNAVREILTGLQGRRNLMIEWVNSGEDAMKFIPAASAPSLLQLTPASQLSILSSFARTATTLEHLRRFVDAIFAHAARGSVVPSTTGSSRLIMSNFSRRTTRTFEAFAETIDAQVREFDSWCATQEESICMGQAGIGAPLVVSLLSTEQALRSRFSDTFSSILDILQSVVQRCTRSALQPEVMTAVWTYPDLPKRMCPAAITALLLDSLLQSIQKCSEMGDNITADAMKRVFSDTAEPSWGLIHQWLRDGMPVQDIAPHPTNQVGRALDGRQLDEEFIVEDNELPLLDPDFWKEGFVLRADTAETGTPGAERRSAMIVPIFLQPIAVDLLEAGKALGLLRTLGIPLALGQHYGADQWMASWRSFKDVLHAPTGEHQEVSDEDASQFAGMASTDDFSSMVYDELIGPCRQAKESLSRVLADECDLWLHLIAMEGLYLMRRGDVMSNFVDVLFSRPWEDFHFLNNAFQEICSSTKWIESSLVRFSHRGNKDKTINRTVRAMEGLCIEYAVPFPFTYIWGPHALQTYSSIFVFVLQIRRAKRTLERILVRNTKVSQDNAELKMFYAMRGKLSWFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMB3</accession>
    <name>A0A2R6NMB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMB3"/>
    <dbReference type="STRING" id="98765.A0A2R6NMB3"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="3">
        <location>
            <begin position="803"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1225" mass="137024" checksum="A9FDF0969FEB402A" modified="2018-06-20" version="1">MHGLDPAQGSVLPNIGFTLPPLQGSTLDEHFYRIGSRAAEPWLTLAKDLAATELPPRPEQWHIKAGWTRYYYHPDGSSYFSHVDHPEHDGQPETMLVFDVETLPEYSPYAVMACAASKNAWYSWISPWLLGESEDPQQLIPIGDPSTSRVVVGHNVSYDRGRILEEYSLDSTQTRFMDTMALHVAVKGISSHQRPAWMKYRKDKEKELEEAVDVVLGLVGEETGQKQDEDEDEDLAKKDELRRLRQAMEESLPQLQTDMAVETEAEFESKRWEDITSANSLADVAKLHCDITMDKQVRNDFMTHTREDILDGIQDYLDYCSYDVLVTHSVFCKVLPEFLTACPSPVSFAGILTMGSSFLTVNQEWERYIENAERTYRELEDKVRIRLVDLAYEAKAMVENEKWKEDVWLSQLDWTPKIAGKSRGILPPESVEDLAIHTADDRIPAWYKEILVSGVLGAPAVNRILPYILQLSYQGHPLVYTSLDKWHYMLDGAVTRLPTAKNAKISTVLSLAHGVPALRSNDLTSSHPDLALAIASGERTADLHTRITALMERALTTDPGEIEQDPWLKHLDWTLKVPPSANDDKPKKKVVKPPKPEPVLWPKWFWDLTKPKKDTPPGTLDLTVRNRLAPLLLRLSWQGWPLFHSREHGWTFRVPVGADYKTRLNALTFYDPADEVLQQSSQQFVFYKLPHKDGEQANVGSPLGKTFIKYAQDGTLTSPGDEAKDALDMNAQCSYWISARDRVLKQMVIWQDDRLNMGVKTPQGPGGKWGMILPQVITMGTVTRRAIEKTWLTASNAKKNRVGSELKAMVRAPPGYALVGADVDSEELWISSVMGDAQFGLHGATSIGWMTLEGTKAAGTDLHSKTASILGITRDQAKVFNYSRIYGAGMRHAVLLLLQSNAGMLPEQAQRLAQNLYASTKGKNTHRADIFGRKFWFGGTESLVFNKLEEIALSERPQTPALGCGVTYALSKEYLPAEFGSDYMPSRINWVVQSSGVDYLHLLIVSMDHLIAKYHIQARYLISVHDELRYLVKEEDKYRAALALQIANLWTRSYFAYKLGMDDLPQGVAFFAAVDVDTVLRKEVDMPCVTPSQPVPIPPGESLDIAKVLSKTNEGSLWADGSPMQENAGIDLGVSLKGYVEPDCLAHRASSPAWLRAQVTSEFAEVKLLAQRASGNTFPGRVGGTRAKPNVGHNRPKASSKKAKMGNGDGVDWADTAEQMLSDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NME4</accession>
    <name>A0A2R6NME4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NME4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6183" checksum="B85F9BFDC2110A68" modified="2018-06-20" version="1">MTSLLAFQVPPPVLCHSRNTLLLCLEFRDTFKFVATTQGVSQLRFIESNESAPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPF1</accession>
    <name>A0A2R6NPF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPF1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="179" mass="20833" checksum="B40BB4DE00914E10" modified="2018-06-20" version="1">MDHVDAKDCYYVFTYVLRKLCYSESRELQPLSKLEGQLQSNTYKKLDNGQHFDMGRTQLQKIYNNMIDSQSPLHWEHRSSGVHTMMLELLCSVSKVHMTEGTRLISADGPWVFGWHIDNKIRLAVEMFDQNTGYLDSYARHQFVMMADLVMRSLDDCYYVLDNDLMGTLKVLLSIGTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPI9</accession>
    <name>A0A2R6NPI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPI9"/>
    <dbReference type="STRING" id="98765.A0A2R6NPI9"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="12495" checksum="57A104657FBD4204" modified="2018-06-20" version="1" fragment="single">MINIHLFGQEDSVLLWKAVCSNKLLERVELILFMNKCDILESKLRSGIRLAKYLRSFGDRPNDLESAQKYFRSKFSFIHREHSPLPRKFHGYFTSVTDASTTSGILVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQD7</accession>
    <name>A0A2R6NQD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000957">
        <property type="protein sequence ID" value="PSR74772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQD7"/>
    <dbReference type="STRING" id="98765.A0A2R6NQD7"/>
    <dbReference type="OrthoDB" id="2246127at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1078" mass="120450" checksum="0D5EE37243E98B36" modified="2018-06-20" version="1">MNLWDFSDPPNNEAQDTPENPGLFLFNGRLYRCKTCPNARWQSLKKAAMHEDVNAHVMHVRDLDGRAMHSDPLGPNMDDKNCFNSTPSTPVQLRTDPQPRSPLPPSSPFSDYTAGIPHDATHSDSDKLEDAADEIYVQQQARNVALDTTTVHGPALANDPPHQIYDNWGGFMVYEKTRSPAELEDQDDELDQDGLPSDGIEDAVLTFASSDPLAIEPITYDEFAEQAPSDGIGLSDDEAWYPWSSKKEVSNPIVRPSLHFYPEDSHQRLAEAWQGERWRTEVESTFSGIMTRANDGQDYFVDEPALANTDGLGRIQPVLPIRFFMRDNNMFAKVLRLHIARRDESASDVFVVDARSEDDSFELPVSRLFLSYPRFLEAHKSYGLPSPTTLSGISRNIPGAPIPASHIEPWSVPLPNPWRIKANGRRVLGLPLWCYCDDTSGNSSKKWNKHNSFLCVLGGLPREQVHLAYNIHFLATSNIAAPLEMLEGIVADLQHMQEHGLAAWDCIFEEDVLYIPWLLACLGNNPMQSELSSHIGMQGKFSCRVCHAGKDTKSGEHHRLSTFLQAGAPRTHDETLEALQTQWAAVKAGAPSRVDGLATESGIKDKHFTSFVERFSIEIAKHKAHNRAAGKPATDGIHDLVDKVLDGKDDNFLFNPLFYVKGIDPHADTPVEILHVVLLGFVKYFWRDAVSRQNAAGKKTLKTRLASLNVADLDLPALQANTLVQYAKSLTGRDFRVVAQVAPAVLYDLIPPAAYEAWLALSRLVPLVFQPSIEDIDNYLKRLEDTIDDFLAATALWSVQWFNKPKFHLLVHILQHIRRFGPAILMATEGFESFNFVIRLRSILSNRHAPSVDIAAAMSFMHAVRHLVSGGFIYSQEDSQEDSRRQSGPEVQCLLNDAVFLKFMGMTNLQSKNMMGRVTFLRGQASIAWRNTQAIAKGYRIPMTELDDLVDNCASVKLENGDTARLKGFVLFEGSPQAQASQSNTRLGRIAEIIQKEDGLVLVLITKWEILARVLPYRMPSVRATRCHVVVAVQLTRSTTALEISAQAHCPVWFVRSGMIQIAGKMNISILESRMIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQH7</accession>
    <name>A0A2R6NQH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQH7"/>
    <dbReference type="STRING" id="98765.A0A2R6NQH7"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41450" checksum="AB8F6D04C5B1AFCB" modified="2018-06-20" version="1">MIERAELTSETRHAPLCGASDEMIGRESVGFTLNLHLHFAADSFLRCRQVMLSTSKLQTSLRILLRTRGQRSPNARSIATTGVAGGTQGPNAYCRDLVLKRDYQAFLTSQTFPEEHRDAVFALRAFYVELATIQESVSSSVIGKMRMQFWRDAVKGFPDGRPPQHPIALALYEAYQKAKLPTYHLKRIIDARDAELHAPTHLTVDSLIAHAESTSSTYLYLLLSLVSLSSSETFSHAASHVGIAQTIATLLHALPFHASQGRMVIPAEITARHSVNQEEVFRKGGNAKGIDDAVFEFATIANDHLITAREMMKETGGKVPVPARPVFVSAVPTALFLERLENLNFDVFDRSLQQRSWTLPWRVWRGVYSGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQT1</accession>
    <name>A0A2R6NQT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQT1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQT1"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="315"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR74970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="942" mass="104220" checksum="D47CC9609664F688" modified="2018-06-20" version="1">MITFTPLSGAARSSRKTPLAYLLQVDDVRILLDCGSPDWCPEEASSSTVKEEDLAESIYHWEQYCEALKQHAPAVDLVLLSHGDLAHSGLYPYAYAHWGLTAPAYTTLPVQAMARIAAIEDVEGIRDEQDVDDNPAADSDDQQPEGPPSSRSNSVEVMNPSATSITTRSRKRKFIATVQEVHEAFASVNVLRYSQPCHLQGKCQGLTIIPFNAGHTLGGTIWKIRSPTAGTLLYAVNMNHMRERHLDGTVLMRQGAGSTVFETLQRPDLLITDAERANVTTARRKDRDAALLDCVTATLTSRNSLLLPCDSSTRVLELLVLLDQHWSYSRLKFPICLLSRTGQEMLTFVKSMMEWLGGTISKEDVGAEGQDGGKGGKNHKRKRDDDGDEDAMGAFALRFPHLEFFPNPTALTQRYSSKDPKLILAVPASLSHGASRAIFSEFAETPDNVVLLTGRGEVGTLGRILFDRWNDSQREESKWDRGKIGSNVMMDGNLYLKINSKVPLQGAELEEYLAKERAVKEKEAAKKAAEERRQRILEADEDDTDEDSDSDSDSDDENEVELALGGDMDTSDDVKTPKERKRKGERRNNRDAADWDSGLDADDGLTKQMLSYDIYIKGNSSKATSFFKSTEGQVQRFRMFPYVEKKRRIDEYGEMVDVGMWLRRGKALEEDAETEEMKELKRQNAEEESKKTPQEPPSKFVTTEVEVQMACRLLFVDLEGLNDGRAVKTIIPQVNPRKMIIVHAPESATEHLLESCASIRAMTKDIYAPTQGETVQIGQHTNSFSISLSDELLASLQMSKFEDNEVGYVTGRIASLASSTIPILEPITASAPPREGSRKHLRGHMLGSRPTMSLPQSTMIGELKLTALKTRLASIGVQAELVGEGVLICGAAAKRGVLSDSLEDSVAVKKTARGRVELEGAVSDIYYQVRKEIYGLHALVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRM2</accession>
    <name>A0A2R6NRM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v9164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5 7">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRM2"/>
    <dbReference type="STRING" id="98765.A0A2R6NRM2"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="9">
        <location>
            <begin position="103"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR75406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="296" mass="32527" checksum="39459F6F0408F9C1" modified="2018-06-20" version="1">MARKRASSTSVMPPSPRPEEPAETATVTTRTTTKRPAEKHAASSSKRKATTAGDESDSGPLRATKKAKSSETGETSANAQPTNKVLPVHIEFPPKASGSWRIATWNICGLAASSKKGFKFYVEAEDADILVLTETKVNNDPADPLLTQRYPHRYWSIAEKKSYSGTAILSKIKPLSVDYTLPGHPDPKSVKGRIVTLEFKSLYLVGTYVVNAGTGLKTLDAKKEWNVHFEKYIRDLDKKKPVIWTGDLNVAPTAIGRVKPPNDLTPCLIPYAHSHTPIRPYQSQTQLEQDPGVHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRP9</accession>
    <name>A0A2R6NRP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000898">
        <property type="protein sequence ID" value="PSR75443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRP9"/>
    <dbReference type="STRING" id="98765.A0A2R6NRP9"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="29495" checksum="EA3E227CCDBEEF9C" modified="2018-06-20" version="1">MLEQIQVRLIGPLFQDDLKGITTRGGLTELHQRLVLPGPRLTAEDLMDLMPLLNTPDREGRTPLYYAIHWASYAVEMLLNAGADLQLVKQPLGLAIVYSDSTVIGPLIHAGADVNERIYDRSTPLIWTMKQDTTGKRRCEIISELARHAGDKIDWDARDIEGKTALDYALEVKERLPTEGVRMLKRRSRRDILEHDRGSVMQVGNWEWTYGDGVGYEYLYCICLFVGEECTCPRYGVESTRIREESTEEEEFAMPGSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS63</accession>
    <name>A0A2R6NS63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS63"/>
    <dbReference type="STRING" id="98765.A0A2R6NS63"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015324493" evidence="8">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR75710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11146" checksum="907D5A980AD06539" modified="2018-06-20" version="1">MLVLLVLYVIILSAALDLVPPSTPKGIIAFCNIFPALVAKGGWPYILKGKIQYTRRLLGCCMISVSGMLVSCKTIQDVNIVLRDKEGCRSVRQSLHETIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSN8</accession>
    <name>A0A2R6NSN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSN8"/>
    <dbReference type="STRING" id="98765.A0A2R6NSN8"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11890" checksum="9CA53C82FB7EA0C2" modified="2018-06-20" version="1">MAVRLRFALHGPRHDRIFHLVAINRSIRRNAKPIETLGVYDPRLKAGDEYKTVEWSVDRIKYWLRQGAEPSETVVRLLTLGGILTPNSRFHASLPERKTKATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT29</accession>
    <name>A0A2R6NT29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT29"/>
    <dbReference type="OrthoDB" id="2953893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="12743" checksum="FA159F4581E28F77" modified="2018-06-20" version="1">MSGIMAAVVQTAFAARIWLLTNSRWGRVFIVTLLNMKTGFSATDDIVNRLVRLVIETGSLTGPIMVNALAGRSMGSPTSQNGMNSAHALQESFIARDISLQEIEFDLGTHLVNGSGGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT80</accession>
    <name>A0A2R6NT80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT80"/>
    <dbReference type="STRING" id="98765.A0A2R6NT80"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="272"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR76199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="450" mass="50706" checksum="16149A08EFD83645" modified="2018-06-20" version="1">MPRDEDPLNRVLAPPSNETPDDREARLLAEAEAKRISDAIDEELQQQLKAEKKGARPIKILLLGQSESGTLFTATVFAACLSLSYLEHRQIHHVEDASPMLQSRTLPGSRPSSSPSSPTSPDDVPRLTADHLKLRMRLLPLLQVEEVLIRKLTPPGSIEYEATSLTQITNIPTSLKEKEVVVNSQFAWKGLFNRFTNRENGDAESINWDDPDDPGKIIHACGEDMIHLWADSTIQKVLEYQKIRLQDLPGFFLDCLDRITTPKYIPTDDDILRARLKTLGVSEYRFQVKEGFGSSTREWRVYDVGGHRSLEDSVLLWKSIVSNPLLSRTSLVLFLNKTDILKAKLAAGIHFGHYIVSYGNRPNDYESTSSCTYSGCSSLSGHTETIFVDLKKKFNQIHKEHSPETRPFYCHFTTVTVSNVVLLARSWLNFMTISQDTRATSLILADGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTD1</accession>
    <name>A0A2R6NTD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTD1"/>
    <dbReference type="STRING" id="98765.A0A2R6NTD1"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="214"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR76202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="472" mass="52385" checksum="E6660A87927CD96E" modified="2018-06-20" version="1">MFLFTSQLSRTLGVRGTLLLFVNYYVTARILRAVTPAFGRLAAVEARLEGEYRAGMGRVGRESEEVAFYNGGSRERDILWRAYLRLIKHINSIYKIRIAYEWTEDYVIKYLWSAAGYALIAIPVLLTRKRNIGIQTGVDEKKTDNQVANRTETYISSRRLLLSLADAGGRLMYAYKDLLELAGLTTRLYTLLSGLHSLKPLPVPQGETGDTVSLSRVDVGVPANVGVPLVLVRDLSLSLRPGEHLMITGSNGVGKTAVARVLAGLWAAQGQGKVRRPGGRKGVFVVPQRSYMVVGTLLDQIIYPHTYAQFVESGMTEDELMSILAAANLAYLPSREGGWSTRKEWRDVLSGGEKQRMGMARVFYHRPSFAVLDECTSAVSSDVEGQMYEHAKSLGITLITISLRPSLMRYHTQLLTIAGDGKGSWTLSQVGTAEERMGMDREILAIEEKLAEVDGWEKRVKELTKELSAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTE5</accession>
    <name>A0A2R6NTE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v8519</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000849">
        <property type="protein sequence ID" value="PSR76345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTE5"/>
    <dbReference type="STRING" id="98765.A0A2R6NTE5"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="188"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR76345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="281" mass="32002" checksum="6AD0F282B4F8F9DF" modified="2018-06-20" version="1">MVKPERKLGTADISDLRKDALIQWQHQYYFLLVVIFGYALPSLIAGYFWNDYSGGFYYASLLRMTIVHHGVFAVNSLAHHFGDQVYDDELTPRDHFLVALLTMGEGYHNFHHAFPMDYRNAILWYQYDPTKWFIAVCKQIGLASHLRVFPENEIQKGSLNMELKRLKKIQDRLRWPIDPETLPILSWEAFQEQSSSSAIVLVAGFIYDVSSFLDDHPGGPAILRGYVGKDATAAFSGGIYKHSNSAHNLLAMLRVAALSGGIERIKMYSPAEKMHIVERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTJ3</accession>
    <name>A0A2R6NTJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000847">
        <property type="protein sequence ID" value="PSR76393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTJ3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39716" checksum="73FF86A7FC3B576D" modified="2018-06-20" version="1">MRVPKAKQARKLKSETRKPKGEIRKPKRETKTVQVLGEWYKQFFACAYQRQDTETGAISDCSHHTEQKSNMRTHHRQHTGEAIFCPEPDCSFECLDPARLTHHKQDGHNPELETPKQKSSAPRKTKSVALPTKSARGLAVMDGGSLVLLKPVSHTPGSPQEFYAIQHREIGTVPIPASYLERSAQKPLDNELIYYTAPSEQPNEYYSDPSVDDVPPPYPYSQPLTSSAPGPLSHTSNSLHHFNASHHEYNGHSIQYGSIPQEGYHFNLRIPSGTGQGRLAYPRVVHTPQTSYNPPSYYPDSPPLYELPPPQRSYPGRGRSSFALDTSLTSYNPYNQSATHSSNPPFNYLYNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU93</accession>
    <name>A0A2R6NU93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000836">
        <property type="protein sequence ID" value="PSR76740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU93"/>
    <dbReference type="STRING" id="98765.A0A2R6NU93"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="184" mass="20166" checksum="174B4D17F1C8E446" modified="2018-06-20" version="1">MNDLQHIFEKQHGPVFVTSNPPFEPDADKVVGRYQYDRPILDAAAIRAQSKMHTIQNKEGISFAGAWLNYGLHEDGFTSGLRAALALQCMFTLLLTLSATYSTTASHIARNDIHPPFEIVDADREPQPALASALFDVLEGTGMRSLLGNVLGFWLDFWSVVLLAVCALFVQLLDGSQGVVEMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUF1</accession>
    <name>A0A2R6NUF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUF1"/>
    <dbReference type="STRING" id="98765.A0A2R6NUF1"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="297" mass="32228" checksum="A510F44CC3DC7CFF" modified="2018-06-20" version="1">MLLNGGINPATNATVVPESVIAEVTTAHTIISGRATSPELSISGYGMGWRRESYRGYETIQHGGGIPGISTEVIFLPSKQLGIVVLANADQKDSAEFDIIYRIIEDFLNLERKTPGTRHISSDPLSVSFAKNATGRSLSTRPLTLSLEHYAGTYISPGYPNITFCAPSSRSLDCRDVIKQFQPFEGVSVSSTLYARIPSLWISHGRLRWKEGHSFALSGTNLFPHGYGSDESPFETWEAGEATAEFVVEEADSAGSLSSGIPRVIGLGIMDLSGEVTERSRLPGGIEERAEIWFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUP5</accession>
    <name>A0A2R6NUP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000824">
        <property type="protein sequence ID" value="PSR76936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUP5"/>
    <dbReference type="STRING" id="98765.A0A2R6NUP5"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015323614" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="5">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="21569" checksum="81D3100D3CEC392F" modified="2018-06-20" version="1">MFASVFALVAIVPSALAAISITAPVASTSWAAGQQQTLTWVDDGQSPSLANFSSSMVSIYAGNAIQQTQLQLIVPSVDVSTTGSISFTPDPSIGPNGNAYFIRFESLALKDATNPQFPAEAFSAKFTLTGMTGTFNQTVQAEVDGASTAPIGGATSAPASGASSSAPAASNSKPTSTSTVSSAASGSPTGATNSNGASGLAASFGLVGSVVAIASAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUR7</accession>
    <name>A0A2R6NUR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUR7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7046" checksum="DEEE6B9D02DDF8B3" modified="2018-06-20" version="1">MPHHGSKLRILKTNCVNFVRLTSPNVLRNPPTFIAASMKTSKYHLPNAPLSRLSPLTGLVLAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV41</accession>
    <name>A0A2R6NV41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV41"/>
    <dbReference type="STRING" id="98765.A0A2R6NV41"/>
    <dbReference type="OrthoDB" id="2535907at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="755" mass="82326" checksum="A17074ED0DFDF174" modified="2018-06-20" version="1" fragment="single">MAMHDGIFPAAAKGKAKEEAQCQLGWWELYPLVDGPKRYGSGRHFPSSRQFLLPSPAPFLNQTLTYEPPTTITVSPNDEFVFAYFPGHDGDGAGCLWKKSSQLDSWTVEEWWSFAKGAGVVTAGWTCANREWVVAESGSPYRLPPRGFNTPPNCPTLLLVTQTHQIHVCFIPPCVPSFKILKVSLLQLGRILEGQPPTEDNLSNTYGGNKICVNAAIGMNYNDSVMLVAMRSHLLPSTGSAHSTYGTGDIGLHLGITEPSPPASNLFSTEWEQWGEESQIELCVLLVRFNGLFSVVTKPLPPLSRPKSRLTDLQFFAVPPDIVPPSPTITRDPRRPVKESGIGEKGSIYLVASFLDFEDHTALPKSEITVYPFSRVSSDLVWVAKLERTRIFDSGTLAFVGPSLQKKRLLAGFLDSTVILPRRGSKAKEVAVGNIVVLSLPDLTNDDKWETSHIVSSVDGIGRDIPVGVAVSPNNALICSITASSNVTSRTTVHSGPRHRHTSPVANPTRSDISRVLVCAICSRNSPSDIIHALVTLTTPIEVVTTTLYGALAILDAHSFGLHDMWKNEIMGIATEVYLGRAEKAVSEIDKELLTERGKTAHDICSVAALNWAFEDCRDGDAYDLEAVWQLVGLSTWLISLLERILKQCVFIGENSAPSSSPNSPMKDGGNIDPLASSGLSILVNLIHPYALNNLNTAIAHVKRFRDDLNSLSAKKENSQMAKDVIMDHIACSGVHLDALSESLQELSKEVQKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW14</accession>
    <name>A0A2R6NW14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000770">
        <property type="protein sequence ID" value="PSR77868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW14"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="8470" checksum="A7CB965FE9B6EC8A" modified="2018-06-20" version="1">MSAVSHVKTSMTVMNKLIRSEHNTAASPFNISVSFVGVLPPGIPTSKIPVEVVFILPEAYASYIRPVMQVIPTAVNCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW21</accession>
    <name>A0A2R6NW21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v7604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000763">
        <property type="protein sequence ID" value="PSR78009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW21"/>
    <dbReference type="STRING" id="98765.A0A2R6NW21"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR78009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="234" mass="26218" checksum="830211ECE20D5C29" modified="2018-06-20" version="1">MSTDPYHAVQQEVQTSLQTASTLRASYARIRSTASEDSEELVWARNELKATLAALEADLEDLEESVRIVESTGARLFGLEEVEVLERRRYVGYVRREIDNMRAEVDVDSGLRSRPHSGADMSRVASTGNFTGGSSRPSSPMPDDDQAEWARQEQQMMIRQQDQTIDTISGTLSTIAEQAGLMGREIVEHNEMLDDLEMNVDKTDSKLSDAMRRMKKFVRQTEGIKQNRGGVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWA9</accession>
    <name>A0A2R6NWA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWA9"/>
    <dbReference type="STRING" id="98765.A0A2R6NWA9"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase beta palm" evidence="7">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase beta thumb" evidence="6">
        <location>
            <begin position="164"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR78185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="254" mass="28621" checksum="30A99EC3B4ABBED4" modified="2018-06-20" version="1">MDDMNTRITRAESEASLALIQELFCPPWEFLLAGSYRRGSPTSLNANLIALHPSHQNVTPPSYDGKVPERVGHNTVPFKRSSLSRVKDGILATQVIPSLVERGFISGTFTTGAYKWQGIARIPMKNPDGVWETLFARKEAIAEGRGCFRSVDISLVPMKSRGAALLALTGDQDFTHIMQEKAAKRGLLLNEFGLWRLLPEGEKLKRKDVQYGRWELVASETEEEIFDELQTPWVDPEKRNFSFLKTRSKKVTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX34</accession>
    <name>A0A2R6NX34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v7174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX34"/>
    <dbReference type="STRING" id="98765.A0A2R6NX34"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="638"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="952"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR78987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118053" checksum="0502566F946A8A63" modified="2018-06-20" version="1">MSAPNYEMSTWNDQYVAPQLEQEYGLDPNSFNPMPSDLQSSQFHRRQGTAAPPVQNASFSAFNPSFASNIQRPFTFSAPPPPTHASNMNQSHGNQNLFTPPSTGQLPNQQFGQGSLYTGSSPSMQAQQMTMTSNMYQEKPQVFTHAYPQSGLDMQSSTTVPNNVQIYHTPSPQPYTSPPTSFNQSFPGMDSQSTLQLQNPYFGSDIGRSVPDPYSGPAFKRPRVMDDVGSSGLYEFDTDQDAEEGGVKCEFKTDPETCKRCLNGGHECMIPGRKKRRAPPKREHLLSQIRQQAEHITALMAQLEDANKKAQEVQTRPIDAASPSHTATTESFSLISASRLASPEVESDVPSIGSPDDVTTNADVQDWITKARESIEAFGGYISMGGPSATREMLAGEDHEHSESSLNDDAEFEFAVEDMDGEDAYDEGAVSGDDASVSTSRRVRLDSSTSERRLVKDRLATIPTEATPFGLMANLSLNKNRGIRKIKSKSDLGEEEEDDVGLANAEYFTPSSPIERPLTENHQPPHILRTGLVSPAEVEKLFAIYWDYMNLSLSLLDPVLYTAQKTYWRSPFLFTVICGIASKFYSDRPELYPQAMHYARLAAGTALIGGQKSVEVVHAYILLALYPVPARKWEDDRSWIYLGVAIRIAVDLNLHHPNTAKPRNEQHAREMLNRTRAWLNCFNLDRSTGSQYGKATIISNSDYTANRSDKWWNSSPYNMKGFDIHIAGYNADLTLMGQFRAQIHSDPTNPTGFNKNLDIAALASETDDELNRRWKLWSARIKEHNDPDDVQSTFRNGLMRLAYSYARMNVLSFGFQYAFGKASLGQDMPLLERCLRAAFDVLTAVLEDIAKPNQKIFLKHGPEAQSVFTVFACAFLIKLLQPRYSQFITLEQRDEIRSRVTQIAELFESPEVSIDDRHGPRLYARFLRGLLASRPKRQNLKAKSVSPAAQKVDLFDPPYPRQTNSTPSSARQSMEPDQHPQMYAQSFTMEPSDMSAQFGMNYPEYIAAPLPFESDLLQSMADPSVWPDMVMPGFSWMGDYQQSTLDAHMALVGAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXB9</accession>
    <name>A0A2R6NXB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metal homeostatis protein bsd2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXB9"/>
    <dbReference type="STRING" id="98765.A0A2R6NXB9"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47617" checksum="65B8B3A7621F404C" modified="2018-06-20" version="1">MSSARYAPLPNPRSTIADADREMREAFELDHDDDDEGDHSESTPLSQSYIPSPALRRPPLSVSTPTYDFERDYDYDHPPPGSPPDPAAARPNNYGNSNGNLPSTPVRPNHNHPSFFRRVVGAVLPQHYQRLPSEVVSSHAIGGGMNNDGVFANVMAKPSRAVEVQDANGDIYMVPEEVQGQAPPSYNEAQADAVPQYWENTVHATSLDPNADMIVDDLPTGSWYLFVANIFISYFFQFIGFLFTYLLHTTHAAKYGSRAGLGMTLIQYGFYSRRQFADEIGEIVPATSWNETTEGGPMMTIGGPSEGRRAMDPTNGTSVEVNWDGYDLTSRDWVAFLLMTLGWFLLLSSLAGFYRVKRWEKSIRTTASPSSTVEVQHDANARHNLGNAFPDLFGFSADDENHERQLVDGRPMTESEARLARDLRDAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXY8</accession>
    <name>A0A2R6NXY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000692">
        <property type="protein sequence ID" value="PSR79575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXY8"/>
    <dbReference type="STRING" id="98765.A0A2R6NXY8"/>
    <dbReference type="OrthoDB" id="3265210at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="483" mass="56734" checksum="A7541368D935ECA2" modified="2018-06-20" version="1" fragment="single">AKALKEMNGTFIRGKRIAVRYHEPPDQPRRHTSVSGDEEHTSWFQFAESAKSSDTAAGKTTEAQDDENAQKAARDEEARQREARLKETRMKRELLEAVERMAREARESAEKTEMKLSSQLSQALEVMRDAQQRSEDAKRHLEEAEVTFEEHKRLLEKSAHILIEARSELTRAQQDVDEASTAGEKLLEQQQEALQQKEEAEREEKRVGADRERAELEERQARASCQHESEEDQRKKELAESIRKLQELRKQEEEDRARMQREAELAESRRKMAEFEAEEKRKRAQELAEKAAKRRAKEEREKQLREEQERKAREEREREEAEQRAELERRAAHKRATAAEIERCLLRDQTLWPRHIPWNSHASLARFKSVSAEFDVIKYNELQPLTFEGVPWPVLHWPRKMSFEDIDWQAVEAFFEELESMLPGGEYKILVEKTHRRFHPDKWRARGLLNTVLDDTSRVQLESTGNIVAQAMTPIWTKSRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY48</accession>
    <name>A0A2R6NY48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000685">
        <property type="protein sequence ID" value="PSR79753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY48"/>
    <dbReference type="STRING" id="98765.A0A2R6NY48"/>
    <dbReference type="OrthoDB" id="2658414at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="364"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="473" mass="53034" checksum="6A4BE0CD029DAC22" modified="2018-06-20" version="1" fragment="single">LGADRLPDLGRRNWNKREYFALIKIGREEKKTNTFTSKSPVSSKTLIFTNINHDTNFEAVLYAKRQWHKDEEVGRISVSLMFILESRSPDGSCIVNHDMTSCPGAQLEFLIKMIAPRSLTSETTDAVAEASLAIDHLSPPSAIQTMVRAKNVGVELLEGANIVEEALSPVVKKTDFSAFIKNVEVFVGIVDTIAEVHPYAKMAWLLVKGVYTIVQDQIHRDDKVKDLFLQMASLYEIVGDLRRQLEDGGIKSSTELLSRISKQTLNCCYFIRDYASPGLMKRMAKSTFATVDKRILEYTDAFKSLKDEFHGNLHVETRVIVSLVLKGVERLETTVDLNDMSYSPSSLGPSKRCLFGTREEPLERMTTWANSDSQDHPSILVLTGPAGTGKSALAHTMAHQFRELERLGSSFGFDRNESTRSIKLLFPTIARDLADLNDDIRNALWAAVGKSKEIRMTQDLSLQFENLIAKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY84</accession>
    <name>A0A2R6NY84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000698">
        <property type="protein sequence ID" value="PSR79358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY84"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="21408" checksum="3FB92A1BA0F65DB3" modified="2018-06-20" version="1">MAEAVDPTNEAHAGFDVVWDAKVKAEAIQDVALEKDCSKKLYNWRNNAHKEGQKAWKTWVQQRTKVWKIGELMSGICETQGWGPFKLTQASKTRIDHLTMVWVCFKSRMQRVNAWFEKAVTKEKQLWDGTLPKPFCDAIEALASAGEIWAVTSELQKVLDMEGISSGKLLGDSPDVLTVAEWNLQQELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYJ9</accession>
    <name>A0A2R6NYJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NLE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYJ9"/>
    <dbReference type="STRING" id="98765.A0A2R6NYJ9"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="226"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="273"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="415"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="457"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR80354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="526" mass="57026" checksum="A537C62902C2F639" modified="2018-06-20" version="1" fragment="single">MATLLPPPKRQKVYHGIPEPTPEPPKPTPHVVVQFVSEEDGQPLAPAVNLPANVSREGLEILVNKLSAKDDDPVPFAFHIALPADATVTGAPTQIVISKSIEDDVLSHPSNAFTPEDVFVIRCSPQAVFRVRPATRCSSTLSGHTSPILCASFSPTGNLLATGAGDCNARLWDLFTETPSHVLSGHKGWVLCVEWEAMERKLATGGHDGHVRLWDPKTGKSIGAALKGHSKWITSLAWEPIHLNSSAPRLASSSKDGTVRVWSTLTRLTEYTLGGHTASVNVVRWGGGGLDGKGVLYTASSDRTVRIWDATGGRLLHTLKDHAHWVTTLTLNTDFVLRTGPFDHTGKKPTSDAEAQSFALERYNKLVATTGELMISGSDDHTLFLWSLFPSRTTSEDASSAAAERGGKLKPLARLTGHQRQVAHVAFSPDGKWAASAAWDNSVRIWDGRTGKFVATLRGHISAVYRLAWSADSRLLVSASKDSTLKIWDLKTYKIKTDLPGHTDEVYCVDFVADKVVSGGRDRTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYM4</accession>
    <name>A0A2R6NYM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000652">
        <property type="protein sequence ID" value="PSR80498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYM4"/>
    <dbReference type="STRING" id="98765.A0A2R6NYM4"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR80498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="160" mass="18444" checksum="08F6A1929D56B853" modified="2018-06-20" version="1">MPHSFGYRARTRDMFKRKFGEKGMIKLSTYLIAYRVGDIVDIKANAAQQKGMPHKYYHGRTGIVYNVTPSAVGVIVYKVVGNRYIEKRVNIRVEHIRHSKCRQEFLDRVKRNHDLHAEAKAKGERVTLKRIPLLPRTAHVVSTADNAPQTMVPVRYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYV6</accession>
    <name>A0A2R6NYV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NYV6"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="2">
        <location>
            <begin position="368"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR80741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1479" mass="165680" checksum="52B2644D09106FC3" modified="2018-06-20" version="1">MSLQDMSVPDSPIDSGGMSPRHPAVDKQFATLQTYLNSLPYPCESYDEMLAQLEHIAGKIAICAKSRNWLTLTTWDGVLQCWLLMRYPIPKPTRAKLARLYYELCLLPGIEPRVIRSWSDMLSRLLTSKPDQRPKLEPSELELPWKPLWRVLQKELWPKRRLQNPSRNVVNVLLFVAAVSKRYYPASETPDMLSTFIPMITQDTILTMVPVMASFLPFSGTELYLPTIFNLWGSFNSSIVNDWFLELCGDLAEEHVTGQAGSAEWRDVGIWSEEQWTLLVGRTLGAMNVPVGSVRGASTTASAADQNADKQALRIKHSFNKSNSLAKIIVYSMCLDSPIRGELGSSNNSGVSTPQNGFIGGSRALDSLDKLITSTESYFHPSNHGHWTISLTSFIHRLSAEFCKRWKEEQQPSCKTPVTRRLTPSIRRAFVTTLRTPVLLAMFSKDPFSSTFAQGALRAMALLEPGLVMPDLLERAYSGLEVVNETHRTTAVLSALAGAALPLVSEKVWLGGQKHIVPLLELCIPGIDLNDPMKTLCASLFIVSVVQHMKIGDLSIQQGGVPLSDAQAEEMMDINGHDHSQIPPGTDVGETVILSREEERTLARDSTAGFADWVVSLFRRILALYENLPEEGGKKNTTGGKMEEAVLKSLKGTLDILCLHLSDPLFDLVLQLVYDYGTTNAKSNAVRAFGQLVACLARVKPEQVIAKFLPYCMSQIKEELKHGASSVRTTSTHTAIPSDTTLHWNMAILRGCLGYGGAALLKYREQFIELVSLLVDKTKSERGYTGTGRLISRILHTVASVYPINTRFVNTDKWNDPEFNRSHNIYWGSLYEAEDVKIEWHVPSPEEIDFVLEILDKIASPALDKVENLLATAGKWDNVDRNDFCRYLHPVRSVWSGLPTIYREGPQDVKNPCFYEESEVEALLVTPLALKAGFVLEDPSDPRYQKVVAHRLRFGNVIHRASVALQQNLAGEDHIDAVISVSKAIDVYLLEYAMTRSAFDGLQKAYTMTRDLNRMSPRQKENTRQVFLKRAQAYHSGRALAKGTEPDRMKGALYILWNKGINAKFRGQFLDALLECQHQEKPSIQKLIGNVAHDALTFLTEESLHTDAFTEDAGGVDYAIDALSHEFTQSFLVDETLGEALRKARVRASVKAHGYEDSASSILEIASRPTTHWRYIQMASQMLLNLIRRDSPPSPALARFFVTLSTSPHRTTRSTAHQAIVKITSHIKIRTYAKSTEEIWLDEWHSPLKIDLPIQDPSGFAEGIRKPFTDPNAVPFYVDKLNTGFLAWTPVVKVYQHVGHGPSAITWEAASQPALQAMREVVLDGKFFGQLIDLLGEESNKNPSTLKLRPENVNLMKSLTKMFEHEILEDIFPALEPVLTDSDRYRQRAGAEILVGLIRGSKHWPRQHAEILWTWALPLLQSVYAHLKPDTLGFWEDAFNELLSERDSRRSLPIIDWLLALPLDFQGDSAFASEYPSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P014</accession>
    <name>A0A2R6P014_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P014"/>
    <dbReference type="OrthoDB" id="2804750at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="809"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="592"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="877" mass="94106" checksum="9A5ACF1A4B1F6858" modified="2018-06-20" version="1">MGPGRSPGRLRSRTADFSDLLRGTSKLPSDGPAPPMPEPPLILEPTAPKARRKLPGFLARKRKSTGLVADSGSHRDSEHGLEDDIPAVPDTIVRSTHFSSSVTSTDKPDFMDLDEGKSRSRRETSRQTLIPAKSMPFRVLRGQKSTSFEVSRPFNVTHNATASAISPIAESKLKSKRPVITISAPPGVEEDTSTFSTPRSAPSPPSAIAQTKSSSGHARRPLGFPFGHHHTKKDDAKASSASSPMKEEVQNPVKETFRSAVERPSPTTSLSPMLPSSMKFPVPPQQASVSRNGKGQMSTSLQQASVPGRQEDVALIDAFQSHSPSTTLSPTVSPHTATPSDLSDRSPTPKPTPARPARPTSLIIPNRGSYRRSTSSSAPQVPQSPSSTNSRQSIASLRVRSRRSSRSASPASPPPNHPLPSPPNSATFPTSSDAEGWSTDASTTIGGWTTDASSRIGSVGTIPSLASRRSTLASPTRIRANTIAAGHETKIASTRNTATFSSEDELGRAKNKHIRGNDPAYHLPSFSHGRYSEKDEKETEREKPKEQSRDNIVYVQSQPESRPQTGDTTPTRDDTPTQSLRAAHDTYVRILREKHAAEKADLVKRIERLEKDARRREREIKGLRWLVMNANTEGGGGVLSLEDQLIIGRLRSGSKASEFSHASSGRSRASSSVQGAERGAMSPSNSVEEGLIELQTTVGDFFIPTARSSEISERPGSQGSGRSLRRSNTMPDGFALSAAKRARRSSSPVLPNLPSNPSVPGGLGFDIPSIPGSDSDLSLVTLDSSSLPSLTTTNTTSSTLSIIPEVPSLPAKEESRRASKALKRMSASPQVSQSQSMYASNLKVGQSPSIEQVMDRTSRETSMQEVLKKLRAFGGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P142</accession>
    <name>A0A2R6P142_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P142"/>
    <dbReference type="OrthoDB" id="3256525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44298" checksum="D9801496C4E83D4B" modified="2018-06-20" version="1">MSLSPLPVELWLDIFRWSTISRSTPSLCATTYCPFQADALDAIDQEAVAVKRTLVCVCKQWCHLAKNLLLEDVVIRRDGSSLKRALQAEGEKGGYSRVRRACLPYSSCIPCNSDLTEAAALLKVCPQLEVLVRPIPALQDELRFELPGEECPPLTSLKRLDWWHHNDAARCGGVNALTDVLHAAPNLQYLSLGGDMWLNLLQRKPIELPSLSTLRIRRMNVLFLHQICRWSLPSLRHVIIDTYTNHRLFDDFWSTFGDQIKSLELGRSLKFYVLDMVYHVLANCPNLEELNYYVQFTASPHLPLDRHISLTTVRLHAAPNSFFTEGGNAYWEHIGEHFSAFCQPLFPALKRFVLHGDWEAVRWDSRFRLLTQKLKDRGCVIEFNQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1G6</accession>
    <name>A0A2R6P1G6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1G6"/>
    <dbReference type="STRING" id="98765.A0A2R6P1G6"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="194" mass="21423" checksum="C6C4E693944460A4" modified="2018-06-20" version="1">MDQALSVWGRIDVVVNNAGLGMKSVLEEGGSLAAMQQFQTNVFGVLNVTNAILPHMRQRRSGTVVIVGSPIGETYSAELAQFSIRVTVVIPGSFRTGALAQPITIHKHIPAYDKLREAGRARFNSISGSENGNPAKAMELLVDVVRGEGRAYGREWPMWLFMGQDVYRDVRGKCERVLNTLDDWEDIATDLEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1M1</accession>
    <name>A0A2R6P1M1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1M1"/>
    <dbReference type="STRING" id="98765.A0A2R6P1M1"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="66727" checksum="0F4D1BF5FA3451BE" modified="2018-06-20" version="1">MEEDDLGRPPAISRMPSYIQFAPKRAMTSFENLVALANYEERLREARKIVWRDRGEKPVELADLWECAEHAGRGGMRAGGIAFAIRSGVNFILLLSRIKKVPKSYRFALIRHALFGPESWRFAAMLGTFVALYKFILNSLPMLLPEPRTPHTTQTHSHSHSRSRSRFRVENQLHTSALSSSSHPFYDDGEGVGDLEAGKVPRSKLLYERQARLSMGAQAHVEWTRKKTRRYYSVLAGALAGGLAIMWEKRGRRLGIAQQMFVRGLQGSYNAFSEKRGIHIPHGDVLVFSLCCGQILYGFLLRPDSLPRSYVNWIQDAGKIPKECVSMNRDLVRDHIFKLDDIDRVLNRKDITPANHADLLARRALATLPTPEFGPYFGPCAAVHPWFDSCMNVPTERFLAVFKWLLPIYGALHLIPMLLFKRKNVWMEPMKMLIRAGWGTARSSAFMGIFIVIYQSFFCFKHQTWLFLMALRSPASHSILSVLAKRIPQPMVDFLLSKPSFWIGGLLSGLSLFLEEKRRRPELAMYVLPKGLESAWVMARGKGLVFGFGQYGDIVTRAWKRYFRVCDRDESTTANPVPFGGILLDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1T3</accession>
    <name>A0A2R6P1T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000554">
        <property type="protein sequence ID" value="PSR83720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1T3"/>
    <dbReference type="STRING" id="98765.A0A2R6P1T3"/>
    <dbReference type="OrthoDB" id="2756548at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="484" mass="52925" checksum="012034BC39815286" modified="2018-06-20" version="1">MAAMDDPDNHLAALASSSRYPTSSIRDEPYFRPPPDSPPYDPLNLLESDPPRLALDPIFTKYRKPVHRELVPGLREDGTLTVKHPLVDAFIDGLPRTSPREGRRPPRESWWTKGLKDFTVSDVLDLDVELDDVQDECIFVLAALKLLYHFHHRAHFTLWGREAGPRTARRVQKLLYMSPSPVASPVGWAGIRDQLWLLNGIQRSLFPNKCEGEGEGETASNGMTLRKRKSRSSAMAVADRPRKRTRTAAVHDLEKENAHLFGADVEDVKETENETLSDLPFSAIANLDKAAKVEVINADSEPSIVLNALPAPSPEHSPVEEAVPLPDTTRRSSRHGRGATSTPDAHPASLPDATGPTVKPQRRSLVRARSSSSASEAGSSTAVSDNGSTASLETCVEAELDASVVVRNKRKRGGAVQKDLVDEIVQEEVKVRASTRVRKLAPKKAEAVAEAELLGKETVVVKSGAPRKKGSVVAKPRSRATKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P267</accession>
    <name>A0A2R6P267_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000557">
        <property type="protein sequence ID" value="PSR83550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P267"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="175" mass="19454" checksum="8BFAB5002EB5A8ED" modified="2018-06-20" version="1">MGTKHQQFEVCTYWEIGQWSESVRPPRTTHHAAIQTENNMMKVQNGLIEQTLRETNGGKPECGVDEEKRATSTNGDPSSLAVGSGSSNSCNLILLYACGPRYMQMHSVDSDPSTIFKIKSSKCHVGKIQSGEIVANAKRLRYRRSARRRGSYHHFPVGWRAGPLQTFDNESVGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8V7</accession>
    <name>A0A2R6P8V7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8V7"/>
    <dbReference type="STRING" id="98765.A0A2R6P8V7"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR87362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="621" mass="68787" checksum="4B0D5C950BC4E5E7" modified="2018-06-20" version="1">MRSKSLLPKVVNLANPPFEGHSRKTIHGTVYHEIHPSSTQTTGHLCSGNDNLNIDGSSSSKDRLFAILLGGVADGMNYSSWKKLQQIYDSEHSNLVLKDLFAQDPARFSKFSREYVSPDGPPVTFLLDFSKNLITEPILGTLLELAREAQLETYRDKMFAGEHINTSEDRAVLHAALRNFDEWKIAEAGVDEVSGVLAHIKEFSEAVRSGAWKGYTGKPINTIVNIGIGGSDLGPVMVTEALKPYSKRDLNAHFVSNIDGTHLAETLLVCDPETTLFIIASKTFTTQETITNATSARDWFLSTAKDKAHVAKHFVALSTNTKAVTEFGISSENMFQFWDWVGGRYSLWSAIGLSIALVIGYDNFEELLKGAHGMDKHFRTAPLEQNLPVLLAVVGVWYNDFYGAQTHALLPYDQYLHKFADYFQQGDMESNGKSVTKGGQRVNYQTGPIIWGAAGTNGQHSFYQLVHQGTKIIPADFLAPATTHNPIAHSKHHRILLSNFFAQPEALAFGKTEEEVRKELGANASEPLVKSKVFEGNRPSNSILFPLLTPATLGALIVLYEHKIFTQGVIWGINSFDQMGVELGKVLAKNILAQLEKPEDVKSHDSSTTGLIHYYQKHRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBZ1</accession>
    <name>A0A2R6PBZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000504">
        <property type="protein sequence ID" value="PSR88665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBZ1"/>
    <dbReference type="STRING" id="98765.A0A2R6PBZ1"/>
    <dbReference type="OrthoDB" id="4772102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33672" checksum="404578CA42F4A23A" modified="2018-06-20" version="1">MSRPDRHPIAAYVFTIGGAISWSSKRQDIVCLSTTEAEYIALTHAAKEAIWLYHLLDEVFPERFKLPITVYSDNQGAIALSKDDRFHTRTKHINIRFHFVRQYVEDGTLNITYLPTDRMLADALTKALPGPQLTKLASAIGIQTYKTQANCAFLVSMPSRPTQRYHQPSLSSRSDGANPPSYNSYSRRRPRQNHPFVAQPTLPEQLPIPTRGPIRLTTATPHQTKAWYPIPISHAKTMSTIAFIGLAVLTITAIICLHAYVLTKFMLLMSQIVKESQTSTSNNGWGSYDNNNNGGWGTTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCD1</accession>
    <name>A0A2R6PCD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR88985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PCD1"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="921"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1436"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1352"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1379"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR88985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1544" mass="169857" checksum="783B4C462B4898C9" modified="2018-06-20" version="1">MDLASQSEDWTKLRTHVDPAPILRPEDASSSVSVAPSLTLNDVSFSLAAIAPHITLSPAPRLPLPPRSSKSKPRRPSTASSAEEKCPLLPSSTYQGDLSAMSTPSVGSQDYESLLESDIRFTEKPSIQEMNRRAHAAVAGLRAEASRLAGAVDMLPSPFDPSPTDEQLTQRLQHQIDTQIDYDWATFINAYALGRWDPLKTPHPPRSQLQPPTLGHPMRPSSHSVDGLDMCDSPELASPVGFWEPGYSELPYTHESPNIAQTSLTGSAPPQYHVPNSIPIASGGPPLPALPEVGIASRRSTMPLNLGFAHRLRSSFADMRSSNGQSSHPHSGTADSIRPANISNADVTTTAAAIRLAAARVSIAPLALPSPEHELTDPMRGVTATIPGSHPPEFLTMPDSLPKSPNTTRKTRLSSFWQGTQDVEEIRLPTIEASPPETMDDPPAHPPTHPPTHAPTAHNGLNLPFAPSVVPATAPVKVSVENEDDDYFGSTEAQKYFDSASITSDHQSVGSSTSVSRPDHEVSRHSSAPPFDYQPATVPALPRRICLTRQTSAPLPTVALYERRLRTARPASESAVLSLAGRSAKEEQMFGELGYLTPPNPPDELERRRALYKFNIWNTGHDVNFDRIAHLVKLVFSTRIVTISLVDGTEEWIQHWHVSRPEGEFRDFLRLIEIISRLSLIDDTPRREFSPRQRHTLKEFAQITMRELELWRDKIQLRIRDRIQTSMEQFTRDCLEVDKEVDGNPDRAHGLFVGTSMEQVYERAAKLVTRTLDVEGAVVMDVSHVDVLETIGAESSTSITIHSDDPKVGSEGRMLNAEEYSRLQEFFSRYPDGKICEGVLPAGLRPFLPARIQYALAVPIFNIDKRPFAILCAYSTGERTTPFLEGHELSYLRAIGVIILSAVLKRRMILADKAKSLFISNISHELRTPLHGILASAELLSETRLDHSQASFLQTVQACGTSLVETVNHVLDFTKLSGNSKSGGVENTIHRTKVDLMQLVEEATEGCWIGHRARMFTSEIGSVYSPPKQDPQALVETVIDIGHSERGWTFKCEKGGIRRILMNLFGNSLKFTSNGFVHVMLRQQPAPLGQESKQVKLELSVIDTGKGISQNFLKNQLFHPFSQENPLQTGTGLGLAIVNSIVRSNSVDGKVDVWSAEGVGTEIKITFTAEAVEDDEISGRDAELVKVYDSLQRPSISLVGFEDPHRGVQLLRNVLSTYLVARWGFSISSGNGDISIVNEDCDHVVRAMAEKGPKRPFVILSSSRGDPKLMAVVGDYERIGGFCRIVYKPVGPQRLYSVLKLCLHALNIAEVSRNKVADDLEENQRIAHLHESPSDPGGSLYLTGMLSRRYSEETGHNKKMPQLRPSMGPRAITVHPLSSWSDLASTSEQEESPERETRPESPLFSQNPSSPTISIGTGGSLLKSSMGTLRPKGPIRVLVVEDNAILRNLLARWLKNKGYEFREAVDGLDGVRTFESDGHFDVVLVDLSMPVLDGIGATAKMRQFESAYKQPIHTTETHGARILALTGMSSLEDKRRAFEAGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG76</accession>
    <name>A0A2R6PG76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG76"/>
    <dbReference type="STRING" id="98765.A0A2R6PG76"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10958" checksum="F268E465279B2512" modified="2018-06-20" version="1">MFRRRTVYICLCLLATVLVGTVLVLSSVSFYTSISPSAYISEAELDTIFDDSRWNATEHGKVERVPRIIHQTWKTESLPPKWSKISEHCREIMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ89</accession>
    <name>A0A2R6PJ89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ89"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR92199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47377" checksum="FF702A62985F712A" modified="2018-06-20" version="1">MNRPIIPPELADMIIDHLRNDKVTLASCSLVNRTWVPRSRRYLFSSLTLNKEAVRNLSSFQRLLEQNASICLNIQELSLRNSSDSLVEYMTSPPQELFHILNRLPALHTLRTAYITYPPLHDLSPRVEWRPHRKLRLLEMVDTSGSRVDIAYTLSLFANTPVDELRIEDCMVYESMYPPQFDSQRLMFLVSRMSGWEVTRLVLHGVDLTGGYADLLTQILSPGHIQCLTAGEEPCIDLTGSYRMLFDRFGHRLSHLRLDTSSLNVQHINGTELISHSHVVLRAYLVQCTSLQSLHLQISSRRIQAVAPGPLESLDSVSPLLELVSRTITEITFGIGDCGDGACINMWLRTVKWEYLEYSLLSLQNLRCVTFIAQKELFGDWGRGRAPMKFLDYQQEYVQYQGLPALHEAGLLAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMV9</accession>
    <name>A0A2R6PMV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMV9"/>
    <dbReference type="STRING" id="98765.A0A2R6PMV9"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR93749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="284" mass="31961" checksum="DAC85DF796734BEB" modified="2018-06-20" version="1">MSFLRAYVSGAPSVNLVVARLARTRTHSLAVHRMLSTASRLQAQPVEPGHKHPKDYLTSSIAPKSPDIMASYPSDRKYGNATNPYKGGPSAIEKAVHLFFFTEILRGMWIVLEQFFRPPYTIMYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIESEARLDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVETQNQEYSTETREELLYNKEKLLANGDRAEAEIAANLHVKDTDEMYQRIMSTGDGIGAQKPVEYLAHEGQNARTCPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN18</accession>
    <name>A0A2R6PN18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN18"/>
    <dbReference type="STRING" id="98765.A0A2R6PN18"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17602:SF4">
        <property type="entry name" value="RIBOSOME BIOGENESIS REGULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR93801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="312" mass="34643" checksum="2222380D16AEBA26" modified="2018-06-20" version="1">MDVSDILANHDAKQKSIIVEKEIPLDIDAGYLVVTDLTPADAESYEADLEEYLTTTARDGVQALIGSLFSLPTTSSADGPLAQLPPPTTQLPRAKPLPKPKPPTKWERFAQAKGIQHKRKDKKIWDEEKQDWVDSWGWKGANKKEERQWLTEVPANADVDHDPAKIARDARKTRVAKNERQQAQNIARAQGTPKDTPAPVVHRKQEIDRTLATTRTSTASMGRFDRKLDGEKKLKGVKRKFDPTEVSASAEKSQNLDILNKLGREPSSKRARSGSNDVLNVRKAVRFASKGKGSMALARESEGGRGKQRGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PND7</accession>
    <name>A0A2R6PND7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Voltage-gated hydrogen channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v4521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PND7"/>
    <dbReference type="STRING" id="98765.A0A2R6PND7"/>
    <dbReference type="OrthoDB" id="427456at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030171">
        <property type="term" value="F:voltage-gated proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031846">
        <property type="entry name" value="Hvcn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480">
        <property type="entry name" value="F20B24.22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46480:SF1">
        <property type="entry name" value="VOLTAGE-GATED HYDROGEN CHANNEL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR94093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27329" checksum="E26F7308A52C3998" modified="2018-06-20" version="1">MSEQEPLLRADPEMEAELGRGDAAADEKGHIARWREHTAEILECRPWHYTVILLARISLLSSLWYIICNDVLTDSVCVLADLGYTVLSDTCTPVEGPEAPLWLEILSHTSLAITTLFLVEIPITLWAMGISFYNPFGSIPHAGLHLFDALIILTTFVLEVVLRGRERELAGLLIILRLWRLVKLVGGIAVSAGELEEEDAKTLAKTRADLSQALKSLQEAQEENQRLRARLAYGNDDDVTVTGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNF1</accession>
    <name>A0A2R6PNF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNF1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="5030" checksum="169F676DA34BE6A9" modified="2018-06-20" version="1">MTTPAQTPNGGSPLPAVPQGAGNPAGTPVMAPTRSAHGKDGGNSTLGTFGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNI4</accession>
    <name>A0A2R6PNI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000449">
        <property type="protein sequence ID" value="PSR94466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNI4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="7860" checksum="F8FDF78B1C5422DD" modified="2018-06-20" version="1">MAANNENKQLPLDNVEAIDRTPGIDDMELGEAVEEVHHVVTKEAIETMLQSQMSPSEQLHVNHVIKVARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVC4</accession>
    <name>A0A2R6PVC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000439">
        <property type="protein sequence ID" value="PSR97376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVC4"/>
    <dbReference type="OrthoDB" id="3260017at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="537" mass="60662" checksum="17079B8AC27709B0" modified="2018-06-20" version="1">MENSTSQESCALNPDGQLKDASEITFYNSETDETPLAPVDEQAEQPVPKPRKVTKKPMVLPAQVVGRARRVQKPSFKAANVDVNASDIKRFFSRGSNSAEKNGGVPAPVAAHSKLTRTAQPSVSNKRKHSSSEPQHQDASVHNKNRGGREQWGFYEREAAELNSSDMTENEHNKPPRKSRRGSSQRSGTSDMYNGKTEEQHADNDGGNNSSDDEHVDDDDKQTDDANNAELENDEGTDNDDPVMAYDCICEEIGNEKKARKRNHRGNDDRTQDIRNLFQPFEFEESGVLRKGHECRVCRKWNTHGKAYIKGCEEAGIAPHPHAQPMATVEEARDESERPRSGTLDGFVQTKWTSEGLLDHVVEFLVAHDLPFTTTGRGSFRCLLKFQRPQTKDRDIPSRTTVHDRVHELKSVLEERLIEVFTVGWVTSDNATVNDKAMRALQRVLDKLNSRRWIGRKRRARCLEHILHLAAKAFIEALGRPWFENDENGVDENENENEDKEWIDPPDDLDDDDEVDKPIDFDPADLLSKLLALINQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVF4</accession>
    <name>A0A2R6PVF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVF4"/>
    <dbReference type="STRING" id="98765.A0A2R6PVF4"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39407" checksum="8CE31E3981F2B963" modified="2018-06-20" version="1">MGLLILSASDVDQATSKFTPDELVDLMAKVFTNLSRNTQEAKEGAEGVCIPHRGTILSSNHRVLFMPSRLSAIGTAIKIVSVPTPSAPADARERGLPASTMVIDDRTGEVTAVINARKLTALRNAASSLLASQLFVPPLCPSGSSPRVLVAVGAGAQIAAHLSLFLSSYPSITVCKIYNRSANARLHSLVESLKAMHPSVQSTGVALPNDTDGENLVEKQQFSDAIRSADIIVTATSSTVPLFPSSYVSPGTLLCLIGSYTPVMHEIDTDLVKRGGTIVVDYKAGALAEAGELIKADVGPSDVLELGELIQTSNPALSRWAPRIDMIERVRASGDVTIFKSVGVGIQDVAIAHAVVESARKHCLGTVVDDYDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVH5</accession>
    <name>A0A2R6PVH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000438">
        <property type="protein sequence ID" value="PSR97381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVH5"/>
    <dbReference type="STRING" id="98765.A0A2R6PVH5"/>
    <dbReference type="OrthoDB" id="2753189at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="238" mass="25628" checksum="C30A45A0F77249A7" modified="2018-06-20" version="1">MEEEMDAAGVVLEDGDISMDDPDADESEQDSAIVFQGDFFGDDYQGADFDSEWPEEFPQGQSPEADPPPVSENEGSDDGEEVDSEEVSHPTGAGLHIPLDNSIDSEGPNYYSVDIPDYDSHARLRLERALHQKVHIQTFCTQALPETVESQPPAVATPQPGAAISSSLQGGIPRSPSGYGLYEAKLHQADSDGGSNMDYAPFTSKLEWEVARWAKLHGPGSTALTDLLSIEGVSAHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYW5</accession>
    <name>A0A2R6PYW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYW5"/>
    <dbReference type="STRING" id="98765.A0A2R6PYW5"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR98928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25759" checksum="EDC7991854FDF4AF" modified="2018-06-20" version="1">MGKMPFSTLFIDQWTRLPPALQADLSGKSVMVTGANVGIGYETAKHFASLQPKRLVLACRDEKKGRDAIVAIEKETGYEGIELGILDQSKFSSVLEFARRFGDEPLDVLVANAGVLPQKFETTEDGWETALQVNHLSTALLSFLLIPTLVRTARSHNHNLTETTDGTAGKDPTFSRLVIVSSDVHFWTSFAKEQYQAEAGLLKTLNGQTDGHIAKRYFDSKCTFTPTEQPFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYZ9</accession>
    <name>A0A2R6PYZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000423">
        <property type="protein sequence ID" value="PSR99180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYZ9"/>
    <dbReference type="STRING" id="98765.A0A2R6PYZ9"/>
    <dbReference type="OrthoDB" id="2802125at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="309" mass="35190" checksum="B2FCA612BBB12F0C" modified="2018-06-20" version="1">MTMVDPHLIFGCEVGLDVESTHILPLEKLQHTYLRRLLGLNKRSAISVLFTETGLWPITYRRVQLALRYLAYILRDKPALPAAALEESFALANAGHASWFSDLFLVLHQLPVPVAMDLSIKPTSASTAELIAQVEKSLIQHLEASIAISDRLILLHERLEYAPDIHKMVHRTLAFRQYLHIRSYDHRRAVTRLIVSDHPLAIEQLRRVPPARRVPRELRTCRFCLEEGAIELEVHVLLNCTDERMVDLRETFTCQAFALAPALARQRNELTDLNFLRTLLSRAVTLDLFGGFVHAIFQLCAQVPMVTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ14</accession>
    <name>A0A2R6PZ14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000424">
        <property type="protein sequence ID" value="PSR99173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PZ14"/>
    <dbReference type="OrthoDB" id="2801422at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="212"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="503"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR99173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1935" mass="217728" checksum="D5D4D79A90982616" modified="2018-06-20" version="1">MADLNVEVLVVLTIVELKAAIAGHLLVPRAEKDRKDRLVAYVVANTDADLQAELLERCAAKAALQQDTQRSRKRKRVLAARTLRRDQRLRYIETQEQCDPCRYMDLPSELKLRDCFSAFIEVTSNSAVQHVICGICAQEVNRIEADIQCIPIADLPNAHRLIPCRSHPAHDLYNENFLLEPEGVMITDEGTTQSVNVCSDCMKSLQSSNDAPPSLSLANNLWIGRVPWELQVLTVPEQLLVALVYPRVFVFKLYPKDKDFRSNQATLQSGMRGNVSTFEQDIEGIAHMVDGKLMPRPLDILSSIITVTYIGKGTLAKHSLHSTFRVRRGAVRAALHWLKVHNTKYYGDIQIDKEMLRTIPEDDVPDKIVDVIRQSTDVGIVDEEHAGYVPDDDSGAANDEPDVIPLQVSGSVDTDLTKMSTSELMMWGLANLWKDGGEGGYSVRHGRQPVRDFPPRTADNVAETEDNQAVVLNYFERAFPCLFPYGFGGIEGERVVRVDFSTHVKWALQYHDRRFRKHQTFPFVAFGIKQKRQALSHACIQMSRRDFEHDALLMSNITVQRLEKARVEEEKGLPITDPVVLLLRKHVHATAGRVVGTDHSRFRLRSEIRATSIAHGPPALWNTINPNDANDPLAQVFTGAQIDLDNFIATMGPDRDQRARNIASDPYGAAKFFHFMIQAILETLMHVKVSKYQVKSGPGIFGEVAAYFGTVESQGRGTLHLHMLIWLKNAPRAEELAELLKTDEFRQKMTGFIKANVRAYCAGLETSASVKAIPSDQSIGYSRPPNPNSATFEADTRLMEVRLARTLQVHTCKIRRCLVPNKNGLLVCKCKAPWATAMEDFVKESGEWGPKRMYGFVNGYCPAILLYARCNNDCKLLTNGRETKNISWYVTGYAAKKQGRQHNSSAILAQGYAYHDKHHRADYVDELRDRQRLLIFRLVHAINKEQELSAPMVMSYLMGWGNVYQSHQYTSVFWSSFVRALLKGFPNILMPNLQSESTPHSEVVETHVAGDTHDNGEMDVEQRDEQVGEDADNESGNRQINQDSDDMITLKINTDGQLHMKSQVVDYQYRGPELSTYNVHDFFTDTYETTLSMRTPPRPRASSSTHVDDELIDSEDDEADQHRAGRDYNVRAKYQPPHPCAGSKQRVVRTPLHRNVVNYAGRFFPSRHDPTTHPFYCASLLFLLKPWRNLCTDLKPPEQSWEAAFEYFEANASDRIQRTISGIQYFHDCRTAAQDRANDDLPLDDSEEPRTGDIVVGGDDMEMGEDFVEPDTMITEEVVARVLQSQVPPGELQHAKHAVEVAKGAKLFGGNNFEWNVPQGDVLNAVGGDLAQLLKWKEQMSRDVQRVNGEAVVPGTVSNQTADIGSVEQLNADALDTAPAVQINTAIHSGEGTLSAVNPAELKDEQFQAFDIIRWHLSETIAGNNPPPLRMILYGEGGTGKSKVIQTITQEFTFCGVESMLAKAAYTGVAASLIDGKTTHTVAALSVKESESQGVTDDAKAKLQTFWKIKRYLIVDEFSMLGKTHVERMERHIAIGKVSGEGHQEGTTWGGVNVIFCGDLHQFLPVAQGKTEFLFHPLYGSTTGRRLYEEFTTVVVLREQMRVTDEVWRDVLVHLRRGEFRRRHIKILRKLVLKPCCAEDNPDFTQAPWDTVSLVTPRHAVRNLWNENAACEFCAKTKAQLFVCAAEDSVHTGRNRSKEVSLAERYAIACRYKTEKRRRKKDLPVQVELAIGMRVLVTENLETDLDLTNGARGEIVKIVLHPDEPEVGDGVVHLQFLPSYVLVKMSRTRASTLPGLNEGVVPVEPVTSTMKIKLNTRSGKTIQRTVHRRQFPITPAYAFTDYRSQGQTLPYVIVEIASPPTGTLNLFNLYVALSRSAGRHSIRLLRDFDEELFRQSHDPELLIEDERLDTLDIATKIWWQQMGGENQMAVARTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ23</accession>
    <name>A0A2R6PZ23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000421">
        <property type="protein sequence ID" value="PSR99320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ23"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ23"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR99320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="25851" checksum="0FFF5355683BC5E1" modified="2018-06-20" version="1">MSRGGRGGRGGGRGGFGGRGGFGGASALPPMGLSFADIQNMSREATALYPPLEPLPVLTEYSEQEKRIAELQIGFAIRLRKSAYYMVEQTKSTELPRYSDKYRPSTASQPTLKRKELHQPFFPQEIFESYFNPKKRKTADRKSSKKRVNLDDLVEDAEDQEKSDAERSDAGSQPAESDYDVDEEYDNDYAENYFDNGEGDDNDDVGGGGGDEGGVSSIFTKTASITPNAPTTDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q280</accession>
    <name>A0A2R6Q280_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000412">
        <property type="protein sequence ID" value="PSS00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q280"/>
    <dbReference type="OrthoDB" id="2742161at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="12702" checksum="7CF9F86A071257C8" modified="2018-06-20" version="1" fragment="single">MHTSTARIVKSPSKLSPSKSSKSKSRVPLLSRLVGSSTQHNGAGPRLTPKLDPFASHRQKLSRPSPSNPPVPTTLPEKASICQQVGEGQFGPTEEVQHGQFRAETESRKKVKTNHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7I0</accession>
    <name>A0A2R6R7I0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000267">
        <property type="protein sequence ID" value="PSS22697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7I0"/>
    <dbReference type="OrthoDB" id="3059356at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="8732" checksum="BED888FFB8E5326E" modified="2018-06-20" version="1">MADKSSSQRPSLNSTIQVGDETDPVKSVAVDPSTTSPALAETTTAVNDFHDFKMDRDGKKLTDDVLIVDWDGPDDPANPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RBM9</accession>
    <name>A0A2R6RBM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000264">
        <property type="protein sequence ID" value="PSS25955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RBM9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS25955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="411" mass="44433" checksum="6F931287B3F967A0" modified="2018-06-20" version="1">MAKTAQKKKQTVAPPPRVSTRAKNANAHPGLVDISEDSDPERANRNSKRKAARSKAKEVKASKETKVVELEQLIAKLQGEIAKRDAQEVVSTRSISEMQLAARASPIEEIEEPPVPPSSPIEEIFEDVDVEMSDHDGGADDEKAGSEGPQSSSEMVVADFEMEAEKTLEDVEVPAAAMVPGGPLRRSNAVFFGRNSQGNVVVLDRSPIESRVALNLLAMNPDQSRKRKAVVHEEDPPAEPPSSGKALRKLEQAAKPAVKKAKTNMAKGLVMNWRDKVAGKGSSSSSPCLHSSSSSSSLASNASRASTPSAIVISSNASTVSPKSSIGATSTLKSIAASQDTTLAAQRLYEWRSNVGKRGIAAVQWLWKDRKLDTEEERSDYVSTHLKPRYYCMYRDDTVHLGFLLLGGLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHZ8</accession>
    <name>A0A2R6RHZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHZ8"/>
    <dbReference type="STRING" id="98765.A0A2R6RHZ8"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="153" mass="17181" checksum="0A73A415BF19E728" modified="2018-06-20" version="1">MSSAHPAVHCEELDWTDTQDASKCPTMLRFLQKASQDLIIGADIVCQISSSSHLNKANGNIQVYDPSIILPLVHTLRMALEGNGSEFKVALIALAVRNQATLTKFLQTAEEYLVVEKLNHDLANEELFWGMKRPIDMANETNVEIFKLQYRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI99</accession>
    <name>A0A2R6RI99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v2898</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI99"/>
    <dbReference type="STRING" id="98765.A0A2R6RI99"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS29750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="517" mass="58734" checksum="3070B951021173B2" modified="2018-06-20" version="1">MHGVFDGVVDEPWRLPSPVSQDDLSNWKERANRVKDAFVTAYLAYEQNAYPHDELLPGTNGHADRLNGWGATTVDGIDTMVLMGLHEMSNKTVQHVAQLTFDRDQSVQFFETVIRYLGGFLSAYALTKNPVFLARADDLGRKLLPAFNTPSGLPTFGVNPLTGQTRSGWMGNVAILSEMGSCQMEYRYLAHLTGRPEYVRVVDHVTEHMRQHEERGGLFPTTYDLNSGDAKGNSYSVGSLADSAYEYLIKLWLMTDRTESKYLDMYLKSTEAIMNDLLYLSPARQLLFVTDAYRNNMAPTKDFQHLSCFIAGVFALGAVTIPNVDPRHAWVAEGLAHTCWITYADSQTGLGPERVMFRNGGTKWVDEVTAWERAGKVGGVPPGVNQTAPIHEGEDMEYTPSDHRYLLRPETIESFYILWRTTGDSKWRDRGWAMFDAIETHTKTANAYASISNVYNIPTKKENDMPSWFFAETLKYAYLLFTDEDLIPLNQWVFNTEAHPFPIFRWSEWETKHLDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM46</accession>
    <name>A0A2R6RM46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM46"/>
    <dbReference type="STRING" id="98765.A0A2R6RM46"/>
    <dbReference type="OrthoDB" id="2592022at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="865"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="961"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS31096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="980" mass="107686" checksum="75034B27047517BD" modified="2018-06-20" version="1" fragment="single">QAHALERENIRLQEEVEVLRVHPDVTPHPAALQVPELTLALRRLSDKLTTTEDILSLRTIELAHARSALTKAQFEVEVANDSMGRAHAQEEESRARERDLERKARGFLEERKLADLVVQEYADLVRTMEGRQSKTSAPSPGRNASDSNVTLVEGLAEGKTGLQKLLEEFNAETERLASETNRLQKENDVLRGKLEAESKRSEGDGEKYAELQLQLDRKFSQSTTDSLQQAMENLRTRHAATAATLNYQIESLHKALSHERRQSEKLRDALDDLSEDFAREAYGRRREVSLRLAFLGREEGLAENLRRWIKKSREMFDRFSPEDGSVTDSRGVFEKTMHDAETLLESLNGQPALEQGSPGSVARLLAAQDAVSTLTRELHEETDRRLEIQRKLAELQISIESHAEIHTGPPRVAPRLEDAPSIDMEETQPDDSGLVLSNITVEDNAAQPDTLDNDIPPRLPTTTPEQPPTVLSELGLPTQLGMDAPSSSSLSSDTPIPTDNLSSQSIRKVEEPSHSSQSMTVASVADKKNEGANAPSLASTPVISLQDALETDGSESAILVDGGPMKLDLRKDLAQSVERSHSLPTTVRQLQAPQNIVTSAETIHQPTPRSHSRTPPGILFPDTYSLQPPSDLSPVDSSATGALSSRTLATPDVLANMTWLTGSDPPAVTISPHAEVFLSSSPGIKHPLLVDLVQVKHRYDDLQKAFRDCHLALKELKKDLVSLSPSGNISAMVRTAVERLDDFNEDARVELEIRVADEERVITGYETLLSVPGAISDEVNESEMDREIRTFIDGTDKSVSRAVQQFTRKLDDLEHDIACVKRTLYESSASTDDTPPKAQPGWSSWTAGILGGSSRPASPAPTFGSVMTSPRTRLKSFSSHSSLKERDASEHDDPFSSLGLRISMPTHTLQSFTPPRGSFLPSIAPHGTRARVSSAPMYMLGLGARSTSFGPVTQSPLSPRAHLEQSHAEAERNDADLDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPZ6</accession>
    <name>A0A2R6RPZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2143</name>
        <name evidence="1" type="ORF">PHLCEN_2v4974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000198">
        <property type="protein sequence ID" value="PSS32102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPZ6"/>
    <dbReference type="OrthoDB" id="2789160at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="18012" checksum="C833146AA5248C25" modified="2018-06-20" version="1">MRGQSTTQRPPFYDTLLPCIGQELDLMTEVPQWLYAMPQPSMSSDGCHPVEFCVNGLRGICLSDALVEGNVRGLANAEEQVANDVGSRVLYRIKMKSHSTKENPFLQVGPGYIELKHLYLLEVRRIDKHSWQPILAIGRRTALWGIESWNRHTISYAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ37</accession>
    <name>A0A2R6RQ37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000196">
        <property type="protein sequence ID" value="PSS32115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ37"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ37"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="618" mass="69773" checksum="09565AB9282D7153" modified="2018-06-20" version="1">MYKIFRKLHLRLLPFLKGFAWPRRHKAAATQKQPSVQRAFGIADITLSILERLKNKDLARCALVCRDWADIVHDILWKGRVDSGVSIRPILGLLDEFYIEHRMARFSVAPSSTSWALFKQKIYAGHIRVLDLNLRDLNCTPWFLEAMLDSMHNPLHLPALNKLHVTVSQDAIELQLAMKFFSSNVTHFVADIYRGYASATGCRHHARMDSLIPIFRNPLDPQTSTLSIAYLLDEFFAAVHQRMPHIRNLAVDVRDSDGAVDAFDPFVNMVLALKELTSLSLPPYTLGVSLIAALSTHQTLRNIVAIGRNSTRAALKWDDSHAIVTQPVARLDGSSARLAELAVTVPIHTFLSFFSKQFDLSNITSLHIIISGEVVASDTIRAVFSLIVDRCPYLENLTVSLAQSYDNPWRITYAILEPLRRCERLVSLDISSTFITDINEEEFEKLVSSWPKLEDLALDGPDAVPVSPDNQVSLSLGVVVELFRKHCPLIFNVTLSVSMILQPNWFMDPGLCRRMNTLRAVTLLVGSATASPTPHIVAYFKSIFPAKCKLRYHPTVHQTAPEHYLMEWEARRSALIAFTDELIMMQVLERIRSGAKTNSSRIDLLWIIDLHLSTVQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ77</accession>
    <name>A0A2R6RQ77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ77"/>
    <dbReference type="OrthoDB" id="3262423at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="208" mass="23360" checksum="D2C71F35D665AF15" modified="2018-06-20" version="1">MEDITTGNINCDLGLRSLRYYLKFIKLASNRGLEGCDPTIHTYELNDKHDKPWLILNVKSLNHSPSELPIIFGELPVTGSVALDLKEETQVKSISISVNYIFQLVGKMTTQDIIIYNFVHVSHELWSLEHKANNLTSEVPEDFNSKLSGTFSFPFSLELPKTLQLQNDGASECYQLPATFYTFLGRVVITYEIIVTVTTGGTLSAEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVQ1</accession>
    <name>A0A2R6RVQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000157">
        <property type="protein sequence ID" value="PSS34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVQ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015318735" evidence="1">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="252" mass="29022" checksum="5EEB24B616702643" modified="2018-06-20" version="1">MSGRNTRSFDAFLVFLNYAQGVCASVRELHLTGFDTYSHSGVISHYLLTTILDHLPSLQTLSITRCYWSPSTGYSGHALKFLRKLSIRTLFLFDFIHFVNILSLFSSIEELDVCDIKWTDLLALSTPAETPTHDIKQYVTRLSPGFRVGELCIENTENFMAFLWCLKQLPFMRSLTTLNIRKLFPDPLDTHPEGLEYFAELLRDTGPTLLNCKIRLPQMYGYWEMSELPFVWRCFLPLLIASTLAFARYGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW17</accession>
    <name>A0A2R6RW17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">18S rRNA cytosine acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000143">
        <property type="protein sequence ID" value="PSS34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW17"/>
    <dbReference type="STRING" id="98765.A0A2R6RW17"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="9">
        <location>
            <begin position="116"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="373"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="11">
        <location>
            <begin position="610"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="776"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="92323" checksum="5FBC9D13841BF1DF" modified="2018-06-20" version="1" fragment="single">MTMDVHARYRTSAHDTVVARFNERFILSLGSCDDCLVLDDELNVLPISRGKDIKAIEEDRGKGKEESELKELKDSLADTKPVGDLVKLAKTIDQAQAILTFIDAIAEKTLSSTVTLTAGRGRGKSAALGLAIAAAIAHGYSNVFVTSPSPENLKTLFDFVFKGLDALGYEEHLDYDIAQSTNPEFNKAIVRVNIFRQHRQTIQYIQPQDAHVLGQAELVIIDEAAAIPLPLVRNLIGPYLVFMASTINGYEGTGRSLSLKLIQQLRESTRPSLTKDAVPADEDGATASSSKKTATRAPPKARTLREIKLDTPIRYSTGDKVEKWLNSLLCLDASILPKSAHQGCPHPSECELFYVSRDTLFSYHPASEVFLQRMMALYVASHYKNQPNDLQLLSDAPAHHLFVLLPPIKDDETHLPEPLVVLQVALEGKISKSAIMEGLSRGYRAGGDMIPWLVSQQFQESKFALLSGARVVRIATHPDYASMGYGSRALQALNSFYSGEYFNLDEVAEPEYSYPDPSLVDESTSLLTDKPTVRAATAMPPLLQRLTERKPETLDYLGVSYGLTPQLLRFWKRAGFVPLYLRQTTSELTGEHTCVMVRGLNSSIDDEVQWLGEFAKDFRRRFLSLLSFKFREFGSVTALSVLEAANTGLKKLDEDPTRELTSTEISIRMTPFDLKRLESYANNMLDYHVILDLLPMVATFYFDKRLGLDLRLSAVQSSILLALGLQRKSIEEVEAELQLPVNQALALFGKLIRKLCKKLQDIQKAAISATIPEAPSRRALENGEGQDTPATDWKPVETSLEDELKEAGNEQTKLLREKQRQMIDSLDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZT2</accession>
    <name>A0A2R6RZT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZT2"/>
    <dbReference type="STRING" id="98765.A0A2R6RZT2"/>
    <dbReference type="OrthoDB" id="3366194at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="27522" checksum="0114F96401FC7E88" modified="2018-06-20" version="1">MRGNPEETQQITDNVGIVVTAPSSPDTKGSPNGSQRRFPSTFLKSGTYKCHTRAADNIPTNLSETLATQASPSYASRPASNFQTTMESLDLPEPGPAYFAARRALWLKPTSSTPVHSELPARLQELLDEEGPLDSDAIWRRGLEKVWKGVIGGGVLKRRLPLRYLVRFLWGPIIKVLQAGWIRDGTWPQGYPAPEPDDELTLQEDRLAMPATTSSHYSSQLTTPMDQTTTSGTPGEHAGVTVQGQPSGLVGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S000</accession>
    <name>A0A2R6S000_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1425</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000111">
        <property type="protein sequence ID" value="PSS35602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S000"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cellular response to heat"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="entry name" value="ClpA_ClpB"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Znf_CCCH"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
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    </dbReference>
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        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
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    </dbReference>
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        <property type="entry name" value="AAA_5"/>
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    </dbReference>
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        <property type="entry name" value="zf-CCCH"/>
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    </dbReference>
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        <property type="entry name" value="ZnF_C3H1"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
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            <begin position="9"/>
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            <begin position="55"/>
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            <begin position="138"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="EMBL" id="PSS35602.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
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    </evidence>
    <sequence length="1308" mass="141568" checksum="2F73D1E326476328" modified="2018-06-20" version="1">MTIPDPPWKQKTRPCPFYSQGRCLFSDSCNFLHEVKVKVKATDITKPVGAIPDITLTQSPSESDSAMPSPASSILRVRSPPRSPRISSLLLALGDIIEKGEDGEDLYDESDEEVVTSPTFTRISGIFGQSVRRQNTDGGDDEGEVEAEDAQDRTALTKEDIGNDTEPTDRHSGTHELPGSLTHCAEFDHDQGELSGLLSPIEVTLAPLAFWPVGQLDHAAQREDSFDSGYADNWTGPSPFVLSPPKTPSTRRYSTLDLLSSPFGTPSRVISPKFAPSNWPSSPLLQHTQTDPSFQPNIEYLDELDSPSPDIPDRPRVDAPQGPDYESTIRRSSFPPLHDTASEEYVVRSVSPVRSPVRSPTTVPEVLSIESTVPTSPIFPSFMVAAIPAVPTSSTFDLTATVTATSAVQASPTLYSPAVVAAIPSVPTSPTLRSPAMVAATPAITPSAFNSPAMITATPATLNPSLTVKPAAPRILTENEEPTANDGDDTVVLRTHSPLVHRASSEYAMPDDQESSSHTQEKNVSHRLSSASTSPAVIQRPVFSPPAVLSPTFTLRSSPSLSRNHSPDGDSPVRLSYDLTPVSSQRASLSWERLSRGSLNSLRTDGPSHEYTDSTAISNPVSPTGSLSSSVPYSPKSTSVISRQPSASDISSQGDNRESRGERKVPFGFRHSMTSRSRDSSVSSRHTSGSAPPARHRPPALNGLSSNRSSYVSRTGGTIFSPDQSSPSSSKLKPLRLSMIINSSSSGSSLLSSGITPSLTTAASSAISHPPSSPSVSSDYSMSHNRLFSPTQSSTIPSHINNTLTLDRSLELDGPYGSTPHSAPITHGFSRKKHPLVNNISSHHRFSYLDRPSSRLSEPAFALVEEDDEYVEIDENMDDTIRGIAVSSAPAFTRPASVASMLYEPVHAIATPRPTLLFAIASDNVEEVRRVLESGEAGPNDDVGPQSALAFALTANQLKHKTDIVKLLLAHGANPSSLKETNGDASRASSSSSDLSPRRPTGSPSHILDTMDPATRYYIARAEAPQTRRASALIHRSFFRPLTKVRYDMIGQDRALEQLFRVLSMPTMAPIVVLLCGPSGHGKSLLARRFGFLLDVPTHTVNMTTLRSTHDIWRSYSMSPYEAPSTCTLADFLMENEGKRCVVVLDEIEKTENEKVLSSLLMPWELGRCSFEAGHRHVDVSKVIWLGTSNVGHDLVFEHQASRESPEETMSRDEYLDLMTLLRPRVSDRLGPSLLSRVTTVLPFVPFTVDEKMAIATEALYSMANDDARNLPAATVEKLVHNALHNYVPAEGARSLYRGVSTELLDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3N1</accession>
    <name>A0A2R6S3N1_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Meruliaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36888.1"/>
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            <begin position="58"/>
            <end position="98"/>
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            <begin position="77"/>
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        <source>
            <dbReference type="EMBL" id="PSS36888.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="11122" checksum="30F40809506D8415" modified="2018-06-20" version="1">MLPRFANPHFLNQSTQIVSRADLDNIRDVIRHEPEEDDDGIVATLETLVKRSLGDFQVMSAKQENTSPERKRKRRKIESDDGKDDAQAATEDEVVCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3P4</accession>
    <name>A0A2R6S3P4_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
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            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
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                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36896.1"/>
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    </dbReference>
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            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PSS36896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9458" checksum="8CE45B02CEA6FFC9" modified="2018-06-20" version="1">MEGCVISTADRRRLYALEGTHGEASIQEGQSDDEQENGKHHRPDVSAVCYTPDIREERKKERGRLPAASEMQYTGKMGLFQHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3R4</accession>
    <name>A0A2R6S3R4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000093">
        <property type="protein sequence ID" value="PSS36916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2554322at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="740"/>
        </location>
    </feature>
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        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
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        <location>
            <begin position="905"/>
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        </location>
    </feature>
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        <location>
            <begin position="982"/>
            <end position="1014"/>
        </location>
    </feature>
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        <location>
            <begin position="1027"/>
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        </location>
    </feature>
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        <location>
            <begin position="1261"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1371" mass="148975" checksum="F65D86DA14F49A8F" modified="2018-06-20" version="1">MSNVGGHNRIHVKSDPTENWDDDFEFQSSHGSNTHTRRSTLTEDWTEPSSPLFKDKKNTLSNASTSLQHWAEPGPSTPSKRTHAIETENWDDDYQDGADSPLRRHATGSSPRSRRSRRRPSMPGPENWDDDFEEGNPASSAGKGTHWDSSSSSDEELGFADREDDRTVTSRSRRAALPRVLPNETPPPPVPPIPSSFMSSHMDPAPFPRSPTASVFSVPVSGRESIAAYSYSSRTHLALRPTLSGSSLGALPPSPPIHHARERRRLRKKSRPPRVEDNIYEMDDRIDVPLRPLTPDQLQPMLAASGTPPSDVQPESTPMSAGKSSLVSRIGSVGKKWGASRKKRASTGPSEVMAQERERATQPRPQSMAIPSPPSTSSKTGWFFRHGGAPGSASGSPPSQQSAMPLRHEKSVDRILSFVGIEQDTPSKRRRQKNGISDDKRRESASGATDGGCSGESDSPAAFLFGEPRRPTSMQVSSSRAQSRPHASRHASYGQARGRETSSSRSSSVARSASASVEELSSKRRDRKMSVKQTHEAQGRSSLDHESGSRSFTSGLRRISLAGKHKRSQSNIAGQTPDRGESGRPSTSTTDTAIPIFPPDRTDDATPRPQSRIKSRPSVDRALLPPIELQPPSPPQTCGPSGLSLSYSEPIPESSALGIDSLLIGHTTPTSTLHSSQTLPLVSSHNLLDTLAVSPSPSPTRMKPSTSPQAASLGRSTHPPKDREQSTVTPPRRNSLGDLKIPARISQAQVGLRRDLGMVREFASSVDQLKDLQFTYSTLVSEVLALLVEIMPPEQIKPRAVSPTFFGFPRPVSRARSNTNPQLLISDRAIRHGLNHQQLTVSFRTIESKYRLSWECAELLIEIGGGGPSQGNESSGSPASPSSTLNPIQYDARKSRERAITLAGDEQKPQLDMQSPHSAASFPSSHWRASTGRHDLSQRQLLLLRDMLGSPDGSIAISSERDIPEEDVNRNWKWGDAMSSTVTLPSEESSHPGSNSGAGGISPIRKRKSGRLGMRGLRDMLRSLKKNYSDSQDSAHNPALPAVPDSSTSISISTDSSLNLPVEQRSQSVVQRRRAKTSVGPDSIKSWREPHPNSPYVTSTSLHHRPSPRRPSLASIFRLGQKSKSSTAKSSPQSGPGIELPLESVQRIGSNSSSHVGSDVPPDEEDWDRVESSSDLEGLSHSKVDVSATLKGGRGRSPYAQQQGGVLGTPKRSANASRSSIWGAGDVPQLSSHSESFQSPGIPEALHHYLRANKLSNVQENAEQGECIRRSGPRRSLSKGKRRASGAPSPNPKRPPSRDNRAITSDSVRSVPAQLRQDPSQALDHDASHDDRFTVAMTPENIKPLLENAKEVHVRCTDCIEELRQLLSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4A0</accession>
    <name>A0A2R6S4A0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000082">
        <property type="protein sequence ID" value="PSS37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4A0"/>
    <dbReference type="STRING" id="98765.A0A2R6S4A0"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="404" mass="45382" checksum="2F28B994F680B583" modified="2018-06-20" version="1">MPRNKTYSALRYDCRSCRRSFSTQGGLKKHKNASHKEAQFAPPSPPVNSFPSGVEHQDGSRSFEDAEEHGGGLDGAPLAVEVTQYHPTMNAVPCDPNGNPVPIDTPPTPPNAPNDDWKPFSSRIAFKLGEFLYKEEQMLQRKINKLFELWTASLLEHGGTPPFTSQQHMYETIDAITVGDVPWKTFSVKYSGEVPDGTTPSWMLSEYEIHFRDPHLLAQQHLSNPGFKDGFDPIPRRDFDSKGGRVYNDFMSGSWSWKQADALAQDPKNLGAMIVPLIFGSDKTTVSVATGQNDYYPLYMSTGVITNAYRRAHCDSVVPIAFLATPKSGRKYDKDPVFQKFRWQLFHKSLAFIMESLKSGMTIKQLMRCPDGQYRHILYCLGPYIADYPEQALLTGIVSGWCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4J4</accession>
    <name>A0A2R6S4J4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4J4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4J4"/>
    <dbReference type="OrthoDB" id="3245657at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015310035" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="4">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="422" mass="44283" checksum="1790201411D69A9D" modified="2018-06-20" version="1">MLLYCVIIWLLTVSILPSSVSAGLVNITVDDTNPDPLTGAVFDYSPLGWSFGPSCSGCEAKPDQTKAYDGTWHDATYDPTFDPSNPGKSVAQTASLQYNGSAFYVYGILSESTSDPGSIADIVFLIDGQPIGKFVYTPPGIAGGYSFNVLLYGNDTIPQGQHTFTIQNGEVGGLGSLILLDYIVYSRDDGTSQSSSSSVTSSSSQSSSSSGSATSTAHSSSQYSNQTGSSTASHGISHETRNIVIACVVSAVGAALLLLILFYCLRRRSRTEGGTTNTVMPYSQWVRNNGGEGYIEAQGVQEIARTPSATGVAPLPLAFHSATIDASEGSSLHPSHLSSSRTADGTAPRSSSDTSRIPAGVSSSLATMAYSTQTAYFPSSKSANIPIHIPANSQLSDKKRVLSPSPPAYEDVESNNSDLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S567</accession>
    <name>A0A2R6S567_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000045">
        <property type="protein sequence ID" value="PSS37395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S567"/>
    <dbReference type="STRING" id="98765.A0A2R6S567"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="302" mass="32997" checksum="D2986CEF18CCA3F2" modified="2018-06-20" version="1">MGNDGGSIPDRRDLVRNKPKAEQADKANQTRARWFFCALSKRRLQEPVVACALGKLYNKDSIIEYLLDKSAYGDGEEICGHIRSLKDVKTLKLTPNTSQAPSADSKTDRAAFVCPLNLKEMNGSQPFVYLWTCGCVFSQAGLRAVSSSPPPREDAGKLEKKGQDLDSGKQLDICPQCAAKYDKTQDIILLNPPPEEEESMFSTMILRRASEPVKSKGKKRKAASGADTPSSEPPTKKNHASSTPSINPNIASASRAVASSLAEEEAKRKANMSDAVKSLYGPKDGVKRKETFMTMGTFTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5J6</accession>
    <name>A0A2R6S5J6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000040">
        <property type="protein sequence ID" value="PSS37523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5J6"/>
    <dbReference type="STRING" id="98765.A0A2R6S5J6"/>
    <dbReference type="OrthoDB" id="3222020at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="93368" checksum="6CD36F643E04F6DF" modified="2018-06-20" version="1">MAGIKPTRAQAMADAVNASSIEANIKQQQSGKGYAIRELISSAQEKLQNAEDLVSKTEGVIDSTKVTKKMVSDLLAPAQAIVSLLDAVADVHPAIKVVAVIVKGVIQLELARHENDKQIAVVYFTMSSLLFLLGDLDPLFGDEQELHQRLHIRLDAVGDTVKDFAKLLRSSGYKEKLSGYASDFADHKKELHVLLTSQSSLKVADIQVDVKKIVAFIDAKTAKEQKVDELIEGMGGLDAALKSDKNLDELAKKLGEKMDTSTRRAVRADIDEALKANVLMFELKLDRISQHIQESVEGSTKTILLKLDEGPHMYIEDPDVQSIWKEMGSRLSAKTRVFLDAVHSYFSRKFIQHELDTGSPHPDVWTLHFLSKIIFYPSIGDGIDEDSSGFVSVHEVNSFLKSRPKGLNWSVAQWIAFWAAAPYKTDVEHQSKIESMVSSLESLAEDVLSQNQKRVKYFCGITKKLNLISVYDNILAFYGESDENDGTYEALEKLRVAWRNLELKRIKANLEKTRYRLKGVEAVAIITDGRRVEQSIMCLIYLLLHHHMKIVKLATVQTVSVAEFEDMRETWEYLFDAFDQRLDTLLEVWRQQRLDTSTQVECYAGGLFKRWHEKNQADEDESDSEEDDESDYDYSSGSEEDEEDGDEDQEGDETGSVDHGRELASVLSSPTKGKGETIPENLLLYPVPTEPEDEDGLSTDDESDWESPAIRRKKADAEMRKRVENIEEKMSVVEDLLRQLLAIQGHGDIKQSQDDQVDNGEHPASSTAACNLKKDLVDHDGDDEDEQNEDDGDERNEDDEDERNEDDGEDDGEDDEDEDEGCSDNEESDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6D5</accession>
    <name>A0A2R6S6D5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6D5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46745" checksum="A59C4517D61DD8DE" modified="2018-06-20" version="1">MSSLLGFDIRIKDDHRFAAFCSFMNIDAPGRSRFLRQMTLYMPDLSQSCRTTLDHIICILQHANQLHRLTIITFDGREFGCLDPRLIGALSSLTSIKDLTLAEVTDDMVTMLQSLQSPVAKAHIHFEPAWLDEIDMDPILVLRNLSSSLRQLEVRWPVFPLAPHYDIQYSLLTELKISENIRSPVLLAPLIYSFPNLRNLHIIDVIDEGEDSEDDIEEHRQANIFSQSQRHWEALDYVSSDILYFYQLGLSCKVHHLRLELPEDHNLNLIKKVLYMVRPTRLDIVCSSDEINYSPMRLDRTVDYLTHLHVKVKNRNSYANTSRIVWQDEVDPWAVCKELLQIDRGSLATRVTEAAPAVRYIVLKLSTEFAAGSSVWQVLRSGGISSLKELTSQDAQRVKSELALGPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6P2</accession>
    <name>A0A2R6S6P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6P2"/>
    <dbReference type="STRING" id="98765.A0A2R6S6P2"/>
    <dbReference type="OrthoDB" id="3028123at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="10536" checksum="1954B5F07D132C09" modified="2018-06-20" version="1">MKALFSSPDAGLDLDLRYVPESNLESVPEPKIQLQLLDLTKKGHLGLSVYSEFCLTEGQAVTFILRTPGQRAYPDAVRPSKEKAGELGVPFESKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6W2</accession>
    <name>A0A2R6S6W2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6W2"/>
    <dbReference type="OrthoDB" id="3364736at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="10045" checksum="3089C39E05BCB924" modified="2018-06-20" version="1">MSLSTTETTVYVLTKYSRAYPSSTSGAQDANAEWQHFTNPVIRLVLDMKKDSRSDLESYRVRILWSINSGQDSMDLDQHEVVFVSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDK4</accession>
    <name>A0A2R6NDK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDK4"/>
    <dbReference type="STRING" id="98765.A0A2R6NDK4"/>
    <dbReference type="OrthoDB" id="2674276at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="13153" checksum="C274774B0681A428" modified="2018-06-20" version="1">MASEETPLLLDGPIPPVDFAAAKEHELVYNRFTPLQKRTIIALISLAGLSPLLISGSLYPSIPQIARDLDTTGSVVRCVRNAAVSSVTAMMIGLTVTTQPCGERINICECSWKSTVGNILEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDZ1</accession>
    <name>A0A2R6NDZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001348">
        <property type="protein sequence ID" value="PSR70575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDZ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NDZ1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="11535" checksum="5DC3731CF96BBC64" modified="2018-06-20" version="1">MSDLEKLPPSEKEVESGTSVSVHEGYDAPVNASGHRDQLDRQYGLLSICATALTIDNAWTALGGSVAYVCFPYISVLAVLKNSLHRIAVFNGGEGARRANVCNRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEB6</accession>
    <name>A0A2R6NEB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001342">
        <property type="protein sequence ID" value="PSR70629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NEB6"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="733"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="756"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="798"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="905"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1072" mass="116166" checksum="283E673B8E6B1A77" modified="2018-06-20" version="1">MATAPKIAPIAPNIFDDDDDGWQDMPVVRSDDFANGLDEEDQKKYHYRPPAKLDLAVGPSNATGNLLDVDYRGAEWRSKVDQNENDYTRLRLNEEDESDEVHLRTRYLFDEDKAMTPLSQMQATKDLLTEAQRIAYVGLCALAAREMSDTLRALNQKELIQAIKSMELWALKILGRLYYHMELATEEQKMIDSLALHGIEAKDLVPALMTTHTVANPEYDPVEARRLEVIRDAEVEAEADRDSNDISEGVFSTPSIPTPAVVVPGLAPKPVQTTAKVFEDSSAVSIPGVSTHLSVADKDVTLDIRWTVLCDLFLILVADSVYDARSRVLLENVALKLGLGWLDVVKFERRVTEALDIQEEVETLEASQNVADVQKSSKKRRYMMLGLATLGGGLVIGLSAGLLAPVIGAGLGAAFTTIGITGTTGFLAGAGGAAVITTGGVLTGSGIAAKGMARRTQYVRTFDILPLHNNKRVNCILTVPGFMSGLQDDPRLPFSVLDPVVGDVFSVLWEPEMIRETGSALKILTGEVLTQIGQTVLQATVMTALMSALQWPIILTKLGYLIDNPWSNALDRARSAGSVLADVLIHRHLGVRPITIIGFSLGARVIFYALLELAKQKAFGIVQDVFLLGTTVTAPTKTWLQARSVVSGRFVNGYARNDWVLNYLFRATSGGLNTVAGLRPVQGVPGLENVDVTDKISGHMSYRTFMPLILDQLGFPVSADYFDEPVEPDFEGDRIVVREEDEPKKKSWFSRKKKSTPATTPRVPRPPSVMSNPSHHRKTSSSASTDDDLPPREAHTPSLATTDSRSTTPTPGDLGKNSQPSTPDVSHLPKHAGFDFSAIKDVIGKADLNPGELQVPAPNRFHAPPIPPPTLRSESAPPPIPEPSSPSPKPRSSLDMHDQPVAGPSSSRSDLSSTLARSMSPDNVHAEADDEEELTSVNAITPHARHEFQSFAAPPSLSFGSNDGSVWPAEPEGTRTPFGTSALGSFRERPTFTASSPSGFTPYGMSRTQDYFAPPDSASMSFAGADGSITFSSSPSRTEPPDPWDIPSSSFGGYNAKKSSNTLNGNLNPWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEF9</accession>
    <name>A0A2R6NEF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001333">
        <property type="protein sequence ID" value="PSR70721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEF9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="6970" checksum="47E57EB8022C7128" modified="2018-06-20" version="1">MGSVVIVVRMTKATGEAGKRETRDGNQVLGFLAMECAMLPGKVILEAHHTPRGIRSSFISVWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFN4</accession>
    <name>A0A2R6NFN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001291">
        <property type="protein sequence ID" value="PSR71195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFN4"/>
    <dbReference type="OrthoDB" id="2799434at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="409" mass="44361" checksum="807A946A75D32F61" modified="2018-06-20" version="1">MNLFSYAISRSIGIPKQQPLPGTSKPTEVPSTEPTWTPLEQTTSNNTDSRPIGPPRASTSQAASQTSRSASGSKIKGKAPALTIVTEKNAVKSKQSQLQQTRLSGRVSETVSEGEVVPLVVTARGDKEVLIASSAFESSKLLKRPAPPSPVGDNPAKKRRVETSASREEHSPVQSASSSRPLTRTRAERARTVSTASSNDPELDDLLPESYANLISKKKLPTPRRNSIGKSQTISPTASKYPNRLRPRLPSPTPSADSPTFGRRSNDSPVANSAAANERLLKSLFSPSGDQDRSSSNILQQLVNAQASRIIDYVQNRGCGDIMLKMKVLDLKTRLSELDKLTEERDNPGRSGNSGKDRLIGKLKDMVLTAQEEMVEIVQKEGCPDIELKLMILDLNTRLTEFKKVGQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG51</accession>
    <name>A0A2R6NG51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v12766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001287">
        <property type="protein sequence ID" value="PSR71354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG51"/>
    <dbReference type="STRING" id="98765.A0A2R6NG51"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF8">
        <property type="entry name" value="GLIS FAMILY ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR71354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="34348" checksum="AA3CA9F6A859CC81" modified="2018-06-20" version="1">MAPNSPYSPSPSPSLESSHEADSSDEDVLYYIEGMDRGSASRSGTPTEAIGQSANGSITGGGMECLWEECRNTYGDLRSLIMHIHDDHIGVHKSNYTCEWRTCARRGLAQTSRFALISHIRSHTGEKPFVCPLPECDKSFTRSDALAKHTRMQHNIVPPAPGRGGNRKRKREEPEPTVFQGPEGYGTFKLEPPDVHGDYDDRISPPLDLYTNGNGSRRSASPDIDVEDSDPDDGIPPYLSALLDPSTGLIMGRPPAMVKYLVMKAKHQYVLEEHASLIEELRAVRFEERRWREAKDAKLDELLRKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGE0</accession>
    <name>A0A2R6NGE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein Mlh1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGE0"/>
    <dbReference type="STRING" id="98765.A0A2R6NGE0"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein Mlh1 C-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="347" mass="38959" checksum="55D1CAB90AA9242A" modified="2018-06-20" version="1">MNLHRSTYADGALVSKDGSPAEPKPCAGNDGTTLTAGSPTPDLSTPSGSSTKQAIGQTYGQTLAKDLLTVKVSSKEDDDGDEAMEDDEEEWSAEAHFSGPNYQAKKTVFLLFINQLTEILQKHVFVGIVDIDRCLSLIQHSTKLYLVNYGALSEELFYQLGLRQFGNYTRIKLDPPPPLRMLVRIAVEAEEGTKNSRLSKADIVNLIVDTIMTRSDMLKEYFLLTINKEGMVETLPSLLKGYTPNLDKLPLFLMRLGPQVNWNSESECFESFLRELAYFYVPEPLVPEEATSSPPAGKTKEQATRWQIEHLLFPVMRKYFAAPKTLLDRDVVQVAHLPELYRVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGI4</accession>
    <name>A0A2R6NGI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001277">
        <property type="protein sequence ID" value="PSR71500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGI4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6572" checksum="87F2EFD826540FD0" modified="2018-06-20" version="1">MNAVIANNIEDVAEEGTVHAIRESTGPETEAVILLKDLVLLHMQEQRVGQFKSSDQVSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGP4</accession>
    <name>A0A2R6NGP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">endo-polygalacturonase</fullName>
            <ecNumber evidence="2">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v12569</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001271">
        <property type="protein sequence ID" value="PSR71560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGP4"/>
    <dbReference type="STRING" id="98765.A0A2R6NGP4"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR71560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="21869" checksum="02037B47BFD42074" modified="2018-06-20" version="1">MTDLTIDDALGDEPNANSNGLPAGHNTDGFDVSTTGELLIIENSTIMNQDDCLAINKGSNITFQGNICSGGHGISIGSITSDVTVSNIYVADNTITNSQQAIRIKTDASATNSFVSNVTYVGNTASGIADFGVIIDQSYPDTLGTPGTGVIISDVNFVDSETSITLDSSAEKVAVNCGSGSCTGTWDWSMLTVNGGTDGEVVNFSGIEDYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGS1</accession>
    <name>A0A2R6NGS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001262">
        <property type="protein sequence ID" value="PSR71590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGS1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="208" mass="23262" checksum="C9250F8A9BFD16A6" modified="2018-06-20" version="1">METRGPFGHNLDLFGESDDVVWNEKSADKNVTWHDHVDYTSHGDFHFLFTHAFPVRLTNYVPHDLLIIHESSLRNALSSSLYNLPVNAVLSLPRQSSGSAPHTQGYCAGWASKIGHIRMYIKYFPPVSPEKYDAFVQDLEEQFETRLAHRRQYVSSGAKPHIGLLPHTENALGAPPHIILVEPSESDSIGDPLHTTASGIKPTTKEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH53</accession>
    <name>A0A2R6NH53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH53"/>
    <dbReference type="STRING" id="98765.A0A2R6NH53"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015340827" description="3-hydroxyacyl-CoA dehydrogenase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6917" checksum="5DA2E61FEA232A0E" modified="2018-06-20" version="1">MKGILMMCVLCSIGLDTCLAIQQTLYTGTGDSKYRPSTLLERMVDAQWLGKKSGKGFYDYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHB6</accession>
    <name>A0A2R6NHB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v12275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NHB6"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR71774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="426" mass="46763" checksum="D62CB6ED18DC6873" modified="2018-06-20" version="1" fragment="single">IREKEDWETELKAGGKYYFTRNQSALLAFTLPQKWKPGAGLSIVATHIDSPNLRVRPVSKKTKLGYLQVGVETYGGGIWHSWFDRDLSLAGRIVLAGKSGYTSKLVKIDRPLLRIPTLAIHLDRAVNEGFKFNRESEFVPIVGLVEAELNKSENDKESDKKPDASSIQDKHHPALLALLAEELSVAQEEIHDFELHLYDVQPATFAGLNNEFIFGPRLDNQFSSFAAVDALANLVSAQSFPTLEGNVNCIALFNHEEIGSVSSSGAESSLIPSLLHRLSPTPSTLAQSIAHSFLLSSDVSHAIHPNYSSKHEENHAPRMNGGVVIKTNASQRYASDSIGSFIVKKLIERKGGKVQEFEVRNDMACGSTVGPMLSKIGIRTVDVGCAILSMHSIREQAGTEDVQHAIDLFSSFFEGFAALDRELIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHI5</accession>
    <name>A0A2R6NHI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 9 (cellulase E) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHI5"/>
    <dbReference type="STRING" id="98765.A0A2R6NHI5"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001701">
        <property type="entry name" value="Glyco_hydro_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22298">
        <property type="entry name" value="ENDO-1,4-BETA-GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00759">
        <property type="entry name" value="Glyco_hydro_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 9" evidence="10">
        <location>
            <begin position="109"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR71830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="488" mass="52412" checksum="DFA7390675A5EEB5" modified="2018-06-20" version="1">MTSESRNNVDVFTTLTFPLHFFDLTLPTPPWLPPNATFGAQPSNTSNASANPHWSTLLGNSLYFYEEQRSGKLPNTNRVSWRNDSALDDGKDAGTDLSGGYYDAGALANTSYATTLLSHAQQLYTFATNDSIPQQTYQTSVPSVGQAYASSGYSDELALAGFFLSLAGNSSDAYTQAVQVYQQQNLSQRLQADPVLNWDEKTPAVALLGLQIAKAYTNLTTGGAQPNWQSDLEGYFDRIVNGSGRGYLTGGITAACGLLYYPGDSDEASLNPALNAAMLLMRYADSGLPSTSSKHSAYIEFAQNQVDYVLGNNPMTVPYIVGMHPNSPANPHSALATGASPADIANVDTVPTQEAYVLYGGVVGGPDAQDRFWDMRSDWVQNEVALDYVAPVLTLAARAIVEGTSDPWYTRLDVGSNEQKKPGGQPCDAAVSDGCTSKGKGWRVGKIVMASLVSAIGMFVLSVGALWMFLVWRYRNGGKLPEAFIANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIG2</accession>
    <name>A0A2R6NIG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v11997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIG2"/>
    <dbReference type="STRING" id="98765.A0A2R6NIG2"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR72149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="20587" checksum="0E0FA62A8842C182" modified="2018-06-20" version="1">MLSRQVSQSLRSLSRHRSLARTARTYATETDANYVNIVEVGPRDGLQNEKAVIPPEVKIQLVERLAKAGMKTIESGSFVSPKWVPQMAGTAEVISKMERLPGNHYPVLVPNLKGLEILLDLLAQHPPSPNTPPPTDEIAIFTAATDAFCKANTNCTIAESLSRLETVTQKALDQGLRVRGHVSILLAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIP3</accession>
    <name>A0A2R6NIP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001205">
        <property type="protein sequence ID" value="PSR72203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NIP3"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18500">
        <property type="entry name" value="BACK_IBtk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="159"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="820"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1152"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1353"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1178"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1294"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1318"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1357"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1368"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1407"/>
            <end position="1418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1418" mass="154410" checksum="389A96818E0F511E" modified="2018-06-20" version="1">MTSLHAYFLLRNQQAFQRVLDAPSRSQSSQAISSSGGKSWTRPSPLSSAASVCDVNARDWLGRTVLHIAASATDASAPEYVRMLLALPGINVNLQDRESHWTALHRALYHGNLASALLLLQRAEIDLSLKDLEGYTAFDLYNSTVEGTKPSANEHKFCADLYTWGANRNAALGLGDGDDRTFPDQVVIEPAQPHSQSALLQERFSPIRVKQIVMSKLHTGVVTTESRANLRMCGFSSGGRLGPGQHTQYQLTPVPQFTHTIVSVALGQDHTLALTQNGEVLTWGLNRFSQLGYIVDTLSGAVLKAEEPIQTTARKVGGLRGKPVRGVAACKTASACWTDEEVYTWGTNNGQLGYDKTAHPVQILPRVVTKIPQPALSVTITDNALVCLLHSQDVVCLYNNSLFRVNFPTYAFPSEIAPYRPPQATRVASIDKITSCDSMIAALSSNGELFTFSLPPVAITGSVEKPREIVKPQRVWALRKKFSAVKDVALGADGSIIICTESGHVFVRSRTGGKTFKFQRVPYMQRVVKVSANSTGAYGALCVDAVPEPLEITGNLLAQDLGLIQPYRGLLTPKDRFIDAVSAKDNSKADPSLELNDEDDASILHDREELLRLCRLLSQHKTAVKGGLPKGSCVFNDDATYQHGADLIIHVQAGSEPKIPVHKLIVAARCPVLGEILAGRRILEYRTPTAESSTHLTFKLNCAKSSQQSHSTAPWKDPARLVISGCHPITVLILLEYLYSDALLALWDWRVAQVLEPYFLGLKIRPAQVKAELQRCAQALELPTAAAALQAAFKAEVAPTVVQQFARVVASHDLRDPLHADVTLALFDKEVSCHSSVLRARSPLFKAFFDDDDWTKNRWSDEGTLKVNLRHLAWRPMRYVMQYLYGGDIEMFETLDFISSVEELLEFMFEVMAAANELLLDRLVLICSSVILKRVNVSNVCSILSEATYYNALPLVRSLQGYIAQIMETLLESKMLDDLSADLIKQLSASVRQAQARKSPLSRSNSLANAAMEKYSEWLSLQDIPQPIVPSMRPIVPRDTAKLSPSAISRKQRSPQASPIIRPQISSRPTAVPDIADDELFMMDNMDGVPPLELALSQAPSKRPSLADLTSKASSGWKVSSVPRVDMKAIMAEAETSKAPITKSVAPLPAARIPSIPSEATNATTWRSPQRSEKPLPASTTNRPPANSPSGPWRSSAAIPSSAAPVLAPAPQATLAVRSPPVKDKPAEVSGLKTSSAVGPGGSSQPSTPQKPGMGPMFSPSKQAATQSSTSSPGSSRRISGPSAAWTLPPVQPVVQSSKSTSGISLVAIQQMQLEQDAPMKKDKRSLKEIQEEEQARQVEEDFLIWWAAEEERLKLEQTTPTTPSKRPQNKGKKGGKPGRANEEKDGGTPSPSRRRPLKRPPCGPKGNNTSQKNEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIX7</accession>
    <name>A0A2R6NIX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v11785</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIX7"/>
    <dbReference type="STRING" id="98765.A0A2R6NIX7"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14605">
        <property type="entry name" value="Nup35_RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR72337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35426" checksum="33F536C8D9BA78A4" modified="2018-06-20" version="1">MENSKTKSQTRCNIRKDAGLTRANTTGVKYCCLFFSRGCCPYGWECEYLHVLPDASIQLPDTSKDCFARDKFSDYRDDMGGVGSFQRQNRTLYVGRIKETGTGPETEEVVRRHFREWGEIEKIRVLQYRSVAFVTYVSEMNAQFAKESMACQSLDNDEILNVRWATEDPNPVSKVEEHTRLEEMGREAIQAKMDPRIVEAMRAVRALEDGVLLDDDEGLMAEEQEDGPRVKRRRLEIDNGDDDDDVVEAQREEVQEPQRPAGLLSADTLESLKYFTEIRQRNAQAAGTLKLSAAPPHPPAAGLGLGGYGSDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ27</accession>
    <name>A0A2R6NJ27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ27"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="16330" checksum="B40BAE774C614465" modified="2018-06-20" version="1">MVRVVDETPELRCSGSYRKPPECRCTVYPPYKSSPRRLLTFNAKTQLSKASRRWFARLLAGMVWIEDLETVIKGWRVRRPMVANDGTWVRRIRALLMGHYVLAVGSSRSLYELRRNVSLYIILNLSAPLFNLWFLHEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ30</accession>
    <name>A0A2R6NJ30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001193">
        <property type="protein sequence ID" value="PSR72364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ30"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ30"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="471" mass="52369" checksum="1C1A6BFD6010ACED" modified="2018-06-20" version="1">MSTDLNFMHSLPPDHFLSLPRPDINVETSTGTVDTTTLAAHDFDVDTRSGFMPPEPPLACLPSLWQPWEDALQAAVDGKLQLGDKKDLSNEDCSRSERWRARIRELPIIPTTELKKSELVLRRAHHVLSWVMHFYIRTLPPDTPDIRIPPPVTVPLLQVCSHLRLPPVLTYSDDVLYNWAFKSPAPTSPVPALDNIRCLTLFTGTRDEEEFYLASARIELRGVEALSLMRATMDEVFVGDAIAVRRITSYLHTLAGVIEDLTKLLLAVREGCDPQVFYNEIRPWFRGADSDGQQRKWVFEGIEMDPELKEPTELSGPSAGQSALIHSLDIFLGVDRYSHASNVTGNSSTAASEKVSIDKPSVSFLTRMQSYMPRHHRGFLRHLSANPRPLRTLVESAGDDELTAAYNDAVSALKVFRDAHVRIVAIYIVGPSRRGARPDGETKGTGGTDAISFVKSVRDQTAGAIINQIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJD6</accession>
    <name>A0A2R6NJD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001169">
        <property type="protein sequence ID" value="PSR72490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJD6"/>
    <dbReference type="STRING" id="98765.A0A2R6NJD6"/>
    <dbReference type="OrthoDB" id="3271139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="272"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="732" mass="83695" checksum="4A79B4E4832084BA" modified="2018-06-20" version="1">MIVSTAKSRSVDERLLQRTPMGDCIHLPVDYFLDHVLPPLPSQVDPREMIDTLKTRGHKSRRAITSQNRWRGFARNPAESLRDESHVFKYLADVVQAIVEASGIGKYDPIVRFQNNPHGGPDYYERDANTLPDAYLHLDNTVDGTVSWMDIAVPGEYKKGCSHTDKQDNIQNISWSICKLLRKDPRRRFTYGYSIENTDMRLWYCDRYRIITTAPFDFMFEHESVVHFFASLIYARPDQLGWDPSIKLLRDDPDNLQYDITVTTKGGEKVTYRTLELLSDLAVGSVIGKGTRIWKVTRLEDGRVSGETAVLKDSWVDKDQPREGDTFHELRNATMPAENHKILMDALLTVETYGDVIIDSGHDAVYPDRTIQLPSSPTPKCARSDFPKWSVGKHKIHHRVVFKEIFLKVLHQAGWVHRDISSANILTDSTGRVKLIDLEYAKKADDESRRDMRVGTAKFMSVELDRRYYRYRPSPVVSPLPEAPPFDPLYTPSTPTSGTTQTHTPSIPSTPPPPEPEPPFRYNPIHDFESLWWVTTFFVFQMEAAFKSTTPLSAQSRPPRLQDQRMSAKRLSHDQDVRFSVTSKRGDAFMKHVQNLHRSIRPIGEQLETWRVKIIRAYLKAEQTRVPDMTLAMQDLHDEFAKDLFRISNMLAGKTVMTEGSWVTNEPVATVPPKQTSLKRKGEDQAEHRDEPEPEGPADPARSRKKARKSRPVVIVDGPAARTRACLRAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJU4</accession>
    <name>A0A2R6NJU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001151">
        <property type="protein sequence ID" value="PSR72616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJU4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="32912" checksum="46E04B042A7D5D36" modified="2018-06-20" version="1">MASNYTIDDFYGDQGTGLGKMPVYSPSHSPSSPDPDQWDVEGGTCAGCSAQGAGFRIPIDSSQVHSGTWKSTTMDPGEPLTTISVQFRGTYTVNESAPIPPDSATISSSASPGSSGSSGSTWPLPVHITTQLPTSSSNPESPSQQSPTPSPPSHKDLAGPIAGAVVGTIVFIIILCALICCLWRRRHRQISVLGGRRHSALPAIPLPVTPLDVTARLVLDQIKHRGPLHPSVPWNSMYTVENETFGSATETQPPQSVMVPSSTSQSHTGSQISFIRNIRREILELRAELDRVRASREGVKPRYITPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK45</accession>
    <name>A0A2R6NK45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK45"/>
    <dbReference type="STRING" id="98765.A0A2R6NK45"/>
    <dbReference type="OrthoDB" id="2799095at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="796" mass="89256" checksum="C81FAF288E67A761" modified="2018-06-20" version="1">MARTVREVDEEKVRDCKEDIDTLLVFAGLFSAIMTAFLIESYQLLSPSDTSTIIDLLKQISSQTNSYTISAGFLNATLSLVAPTEPFEPSISAIRVNVLWFASLIFSLVTASFGILVKQWLREYLAGDYTSPQARLRIRQFRYPGLAHWKVFEIAAVLPLLLQLSLGLFLLGLCLFTWSVHPSIGKTSTPLIAGWAFLFVTVTVAPAFSPRCPYKTTLLKTPLKSLRGLLRRTSLFRPLYEKPWRTELDRQSSSDSVVTQLVREPVVDGNRFLPFEEDDAALDEKNDTEMLAAVDTILLDDDLLRTTMWETLQQTIPAPSDAIKFVSQAIERRLQQNVLSAVSTSIPDLRLLSKRGWGAIVDIVADTLNKNYDFRSLLPSWMEDALIILLSFNDFPLTSNGNRALSLWISSEAHAYTSRIIASHTPDYKSFTHVLRRMRSAFTLCTSEDVVTCLHYILRDRIADGDQDIAFSDILRTESEVPEDTVHSVLVILLDVAMRRLPDDTSPWTVGVQRALNAILSTPVPTCTRPEISLLLSKLMQRETLAIGLMTEIAATTPHYQAFHAEACHNLERAYIDNDFTGRKLILAGQISMIKAYNDGLYDDPKYLPISFIQLCHVYLCILDEAQKNDAFDAGLRSDWRELWIHMAIAARRFKLKDDDANEHAKFAEICLRSLQDLDDRVSLKPLNANVVGDGKHDGYEMGYLEWLEGFKPEDSLFNDDLFDALSIFLPDEAAVKFKRVKCLRDLRTSAQVDAPLSQEISGSSMNDDEVGPEAGQIMDGENGGGMTDAGFGYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK71</accession>
    <name>A0A2R6NK71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001136">
        <property type="protein sequence ID" value="PSR72767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK71"/>
    <dbReference type="OrthoDB" id="2779319at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7065" checksum="8F96B49675B9DD5F" modified="2018-06-20" version="1">MQDEEFTGPSQTFNIYGGFLMTNGCSLISESVETQDSNQMCKGGYGGGASVTCNSSNQSVHSHLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKI3</accession>
    <name>A0A2R6NKI3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11257</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NKI3"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="665"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1183"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1239"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1297"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1415" mass="155292" checksum="F38DA656A279CCFB" modified="2018-06-20" version="1">MQAVEARHASRQDTFDLRDQITTDDHSHHAHELTYTSDEEHSVLEDDSDGEERDEYMEDDDASSSLSIPDEAINFDMVYALHSFAATVEGQANVVKGDSLFLMDDSNSYWWLIRVLKTQEVGYIPAENIETPFERLARLNKHRNVDLASATQAERLEAENRLLASRAASSQATPSPTPGAARSGSRQNRNVNFTAALSVHRYPPAVWGDDEEEEEDIEWDDEGYEDEDPDIAEDLEQERRQKMTENGGVSPLSMEPDDGMSWEDGAVESIQARSQQGRVQAQVVITSSSSEFSVEDQDASYRQPQHQKPIARDPFADGQSRTAAAAASEPTVLRSQSSRERLAAAQNGATSGSPTSPNGVRVMDPAQAIETRKVSLTPQVARSADDHQQPAPASGGPLLPSAIMQQQHEERKRTREEIEALEEAQRKKANKGTSRSSISTPDSKASPGKLRKERDRGDVTTDDESGKGGKKKGGVFSLFRKKEKGKEKEKGVSGGVSENGSIISAGSSDNLTGRNSGESGRSSSQHTHTAESTSPVTASARQQQQQAMQQQQSQKNSADPRRLQQGQQQPQAAATIPISQHASQLRQRDEQQQALYKQYLNRSPASPPEAQPSYGLQSAPLVMPGSMSFSSASSTSGLTVGSRPRPGSLVLSPGAMDGQGVGLPDLSVIRVFAGNNVQTEATFKTVLLNASTTASDLVRQAIQRFRLPAGEDESEYYLTIKQVEGSSAQLLPQEKPLGVFESLVEAALELPKVKRSSVGSISSVASNLSMHPAIKKLSMNDFTDDSAVKFYLNRKGGENENSLSDDENDETLLAESFADSDSEPPRSPGQFLSVNTGGAGVTPERFSSPSYRFALQLIIHPEDLPDDMVFDPLTEAIVFKHTLRDRHSSVSTSSDISQTQRRKVFVFPKNVTVAEVIELGLERFGIIDGVVDGGDEVEDKMTKRRSSTRVRYGLYMDTGGREEKELSPASKVIDAFSRPPTYRVNDRRDTKRRSVDSAQLLLGNAEDIGPDDPIFVLRRAISYRPSSRHRSSAPLDEIALQKLHRESLSGSSVMSDSTISGHDESKRQMTKQERIVAQRIATRANQRAILSAEDNAARGLDVLLPGNAMIRSSRYEVDDRMRYSYVEPDGETYDISDIVEAEWRNEGPNRERAGSARDDLLHGVLSRGKDGLGAKLDRVLSKIKHEKGNNRSQAYQSPSSNNFDSHDPVRNTTPSVYSTAEGRADSRSDTPNAHILNARSPTPTSGSVAGQRATSPVSRLSSYRTASPGESEPRSRSGTVTPSGAQRVIRPPHDRQQSLASVISESSAYRTPSPNTPPTARFNPQAKNNNRQRLVIPKNDFGISEMMAVIETRGMLRKRSQLPPLDAVDELLFGREIDMNSLHPQIKEIYSDTFKQLAEMDNALDDLLHHVAHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLR9</accession>
    <name>A0A2R6NLR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001084">
        <property type="protein sequence ID" value="PSR73326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLR9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6207" checksum="395A5CE3B1DE8F26" modified="2018-06-20" version="1">MLWPIVVNWEANVAGIRHKAEIKAVLKTLVWERDGKPAPETLPPPPPAAPWVDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM15</accession>
    <name>A0A2R6NM15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM15"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="64142" checksum="C76EEE12573E6159" modified="2018-06-20" version="1">MGIIVPVLRLGFVFLNVYETFKTMKLPPRSSRNGGQPSVRAMSQRKRALKGCMAVWLIWSCYVVYEKTLDPIVGIFIPFYSEIKALVLLFFMLTRARGAEPIYLHIFRPLVKPYTPLLDAMVEVVNSIGDVIMLICAVPIHFVSSILSRWTGAHIEELPDEEPSPPSRPDDRQEVPSTETIYGATRTRRGIQQNARDKSNTSKSAKRPTVGSRLPSERASHDIWYPSTAAYEDEDSPPNGPKGLPTPPSEDQLHMARDAVDDEWRRYEAFPSAYPATPATRSTGLPPVLPEGFASLEGISEEVHDGLPRTTYNGFEHHEQGFQGSLKSQRESNPDSDVELSDGHKFAPGVFSSDDEMSIDGGEEEEEDDFNVTLATPYPLSRVQNFSSATTASMDRMTNISSALSTTDNGSPLRTRTNSEASTTLYTSDSSSVAGRKRALPPSADENAPARPVLERHSTAQGTIRGRAIPTRASSRPALPIQRSSTQSSASGAENKDIPDDTSFGSKKRRVGTTSDARSQPIHRVTLRTNVEPPIRKPTPSATASRRAPAVPMAGRLRPTAFAKKNSESASSDSSTRRQGATSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMF1</accession>
    <name>A0A2R6NMF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMF1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="11364" checksum="2ACC1420CA47BCCD" modified="2018-06-20" version="1">MPLQGEFGTICKVTTFGAGCAAALSAQKLYQLSPTAQLRRVKNLLDETRLLLDKLQRQNPGGIEGHSNDYKPYPALQRIYAGRNCREWDIQLLVAAHPSAAAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMH5</accession>
    <name>A0A2R6NMH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NMH5"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16875" checksum="E077E048B534657F" modified="2018-06-20" version="1">MFSVARRAVVSRGPMRAFSTTSSRAADLAKLTLIGRLGKDPEVKRTKTDKEYVMYTVATTNYPSPPPNADGSRPDSKTTWHTVLSFNPSSNSYLSTLRKGSQVYVEANFELKEPDPSADPDTPQGQRQIFLRHETIRVLKPAPLTESSDKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNW3</accession>
    <name>A0A2R6NNW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNW3"/>
    <dbReference type="STRING" id="98765.A0A2R6NNW3"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="19821" checksum="31511EEBF5BFAF6E" modified="2018-06-20" version="1">MADSPTNSLRIETGFNIHDNSDDGILIEPPTPMRERAQRSSQLQGLLPSLRVTSAIERRPQNSALSQGMSKARGESRKLLAHLLGELQRRSMPPPAMEAMDGRATRVEKGLGAVVRSLSGIAGTAGGGLSEGKGRRAAVSELSDDDSDDETSFHTDVTFDLMSKLKEVLVISIAQGWDIFYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNX8</accession>
    <name>A0A2R6NNX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNX8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015319692" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6057" checksum="562CB3A3BB62DDC0" modified="2018-06-20" version="1">MSLRRKALPIFLIPLFHVAAGIETKPPGSNETPVSAPVGGNSNVGVVFVKGCRRGAGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP28</accession>
    <name>A0A2R6NP28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP28"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="328" mass="35395" checksum="EA600EB0135CAEB4" modified="2018-06-20" version="1">MGFTNLTRASSVPPLSSLLSSLLRQDAPLTPTRTSPSSPLPLFDKFTEYQGSNTMKATLAFDTLRGLSPYLTLLANLATQLVCVSGVNQLTSRVSSVSTNLVLTTRKALSLLFSVWWFGNGWNDQLGLGAGFVFAGSIIYTTVASASSNSTSTKPSSAENPAGLNSPGNVKTESPTPARTIPIKREDSIRIPFTPPQPNQKANWKEEDTDDDDNTNTNGPGGHNMLTRRRVHKMEFAETELDLDDGLRGGPVKVRTETRRLPATRRRIEGTVSGGDEQGPEDEDGADRGGEQGPEGEPRELYNGTGVRRGEVLPTLTGDDSGWTTLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPA6</accession>
    <name>A0A2R6NPA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPA6"/>
    <dbReference type="STRING" id="98765.A0A2R6NPA6"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="323"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR74242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="613" mass="67138" checksum="A8BA350B4B44AED8" modified="2018-06-20" version="1">MSGTDSKFPIDLTKLKKLELDPSKPKLTNEQLDTLKYNIQLMRDAIVLFTATGAARGVSGHTGGAYDTVPEVNLLLSLFNHSDSYVPILFDEAGHRVATQYLMSAIEGHIPAEHLLHYREANSKLPGHPELGLTPGVKFSSGRLGHVWPWVNGIALANRDKTVFMLGSDGSQQEGNDAEAARLAVAQNLNVKLLIDDNDVTIAGHPSEYLKGYDLAKTLSGHGLKVVTVQGEDFQSLWAGLCEVINYKGPAAVICKRVMAPGVADIEGTPHGHDVIPVKAALKYFEARGYPPNMAGDILNNIKPNAVPYLYIGSTKEVGATRVIFGEAVNQVLDKISKEEAAAKVMVIDSDLEGSTGLKVIHQKHPEVFIPSGIMERGNFSAAAGFGFDKNKFGVFSTFGAFLEMVISEITMARLNFCNVLCHFSHSGVDEMADNTCHFGVNHFFADNGLSDTQSWLYWPADGAQMIKIVERVFFERGVRFIFSTRSKVPYILKEDGSRFFGDDYEFVPGKDDVIVEGSAGYVVSFGDMLYRSWDAVLRCRQEGLDVGLINKPTLNLVDEQTIRKVGSSPFVLVVESLNQKTGLGSKFGTWLLERQLTPKYGYMGTNKEGALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPH6</accession>
    <name>A0A2R6NPH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPH6"/>
    <dbReference type="OrthoDB" id="2758040at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46847" checksum="02BB9AFEFC12A07F" modified="2018-06-20" version="1">MSIPSLPQETTDLVLDALAGDSATLRSCSLVCQSWLPRSRANLHRRATFAISKRKQSGPNHALERKMDVYRSGALAGSVRELTIKWSPYGSQQDWDKVLAVLRLFKTVRSLTFMSIDRNVLDGISERLLPVLTTQYGGLESLSLTRFSFEKKPMDFFTILRCFQQLRRLGLATVTFGRTARKEESVAGVETVSLLRNLTLYRCKTAQNTVEDCDSLEWLLGNEADPEGRDRYLVFHHQRVEEVNSVLRGVGKSLRSLTICDIQDDRGDLVDLSTATRLRSLEVRPDPYVYGGSDLRWLAKALAKASCPGLAQLTVHVGLQGPGLGHFDTESWEALDGALSSPAFHSLETVELRVSVFVQLSAIERSYLEALSRSQVFRATMVRIRQCMRSADRRGILHIAAERDNFNGQLDDQIALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPM8</accession>
    <name>A0A2R6NPM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000987">
        <property type="protein sequence ID" value="PSR74459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPM8"/>
    <dbReference type="STRING" id="98765.A0A2R6NPM8"/>
    <dbReference type="OrthoDB" id="3260546at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26905" checksum="E6D1414DE28AD821" modified="2018-06-20" version="1" fragment="single">MYVPIDVADQWNYLPEKAAPGTFEDFRKAVFTLYPGASTDRQFEYSDLLAVIQEWQQKGISSLTQWGEYYRAFTLRSSFLKGKNILSELEQRRLFMQGITGLLKQAIERRLEIKQPDHNSSVPYEMKDIFEAAHHILAGVGNPPSSSNAPTFSNPSTGIAPAAPAGSVVVKTEDLSSLFEGFKDMMQAMSSQVRGGPRSNPVGPMAGSMPFVCHYCGIQGHGIQGCPAVAEDMANGKCKKDVFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPN5</accession>
    <name>A0A2R6NPN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPN5"/>
    <dbReference type="STRING" id="98765.A0A2R6NPN5"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="49884" checksum="B3A1EE73674DF3F9" modified="2018-06-20" version="1">MSTSVTDAAPTTLDVPKAERTTSGSRMPSLNQLAARINLNANAASSSSASRPRLAAAFLRTGSQTSLTSTAASNADSTVVNPPSTRSTSPTLLSASPPHSTSTTPSGDKGELLTTEKLEQLNQVTEDLEKDKGEKKKKYPVGYKNIPSLDAITARLAKARSLSIDGSAKPPEAETIEDPKTPGLMIKAPEHPLEHTWTIFHDCKSKVPFTPAPAPGENPPASAHSAPDTDEYEAGLTVVGECDTVESFCRYFNWLKLPSKLERNSNYHLFKSGIKPMWEDEANANGGKWVLTMKNNPQLLDRCWSWLAMALVGEDLDEGDEICGAVVSLRSKVDRIQLWTRNKDDVEKINSIGKKMVKLLDISEADGIGLEFQVGPSGLQLYNDCANLDIPKYNTDDRPTPNKFLSIQSLPQTAYRSSFHTKPGFNSPIAGPGEGPAPPPAPGGAFAGFGVGGGGVLGSGWRGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPP4</accession>
    <name>A0A2R6NPP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000985">
        <property type="protein sequence ID" value="PSR74466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPP4"/>
    <dbReference type="OrthoDB" id="3062963at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="269" mass="28401" checksum="C09292D5F89EDEFE" modified="2018-06-20" version="1">MATLGYSSFFSSGLLAADDDQTTPRSSTIPLEDVTPTAHEFTIPPHTADRPRIRRRRSSLGISASPVSAIKSSARSVHLQRQSLSLFGTPGADNSLVSRVAVLSVNTNNDATMGNSLMGRLRSGSLGAALKYVSSFHLLTPTDQISRPRRPRKNPSVPAAAPAPIAPLPAVPPTLSAVSAQPIPVPRRPLNRRAQTADSLPSPLLTPTISMSRAHTPAGHPMNSPLASGAVYIGMDGQHAYRNTDYPSPLDTPASMRDEYFGADAGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQL7</accession>
    <name>A0A2R6NQL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v9478</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MLYV02000945">
        <property type="protein sequence ID" value="PSR74888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQL7"/>
    <dbReference type="STRING" id="98765.A0A2R6NQL7"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015313809" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="197"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR74888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="305" mass="31539" checksum="4E6257EE894141D2" modified="2018-06-20" version="1">MKTSSAYLSLLALVPYVAGHGYLSQVAIDGQAYQGNVPNNYKAPSPIRLIDDVSPVKGATSGFMSCGQNAANAEVVAPANPGSSVAFSWASGLSTNWPHNTGPLMTYMAACTGTTCDQFNASQAQWFKIDEAGKESDGSTWVQANIQQGQSYTVTLPQNIMPGDYLIRHEIIALQLANAPLGAEFYPSCTQVRIGGTGTGTPDSTVSFPGAYSDTDPGILDPTVYNPGSNYTFPGPPLSNLVSGDNSTAPASSQGPDSASSSPAASTAVPPPPATSPVAAPSSTGSCKSGSKKRMFKRHVMHASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR23</accession>
    <name>A0A2R6NR23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR23"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14629" checksum="9FF7959FD8D1FAED" modified="2018-06-20" version="1">MAKRRRRLTIGKKKSARKVQKTTAMQDVFSSELYSWSGRDDRDRKPTETEWNTTMERCGSFELNGFVFHKGDDAIVHSAEGDDNVWVVRIKGIRRRTLADGHKKSWVHVQWYYSNRDIAELVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRA3</accession>
    <name>A0A2R6NRA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v9248</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000917">
        <property type="protein sequence ID" value="PSR75207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRA3"/>
    <dbReference type="STRING" id="98765.A0A2R6NRA3"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR75207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16578" checksum="A487FA1517EDF4A3" modified="2018-06-20" version="1">MIAHPDALRQAHAELDSIVGRDRTPTFEDRPYLPYINAIVKVLRWRPAAPLGLPRRCIQPKGATVFENICICPGMHLANNSLFIAVATLLWACDITNAVEKDGKAIVPDVNAIYDTGVAVHPSPFECQIKPRFAGVESLVSSVVSEWFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS16</accession>
    <name>A0A2R6NS16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000921">
        <property type="protein sequence ID" value="PSR75185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS16"/>
    <dbReference type="STRING" id="98765.A0A2R6NS16"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34399" checksum="CB2CDA1EF5066D26" modified="2018-06-20" version="1">MGATGSGKTTVSRVGFPNRLISLTLVKFINKISGSDLLTSHGLASCTNEVTLSKDFTLARRTVILIDTPGFDDSTISDTDVLKMIGLYLSTTYEKGYKLAGIIYMHRITDPKVGGVSRKNFRMFRKLCGDDTLKNIVIVTNMWGQVDPERGAERELELQTDEDLFKPVLREGATMLRHYNTVASAEAILLQLVHNSPQALRIQQELVDERKDLADTGAGQEVARELMELKKKHRQEVAELTKEIEEAAKEKDVRAQKEISEERKLYEERIAKAQHDLDNMSKQNEEEKKKLEAKIESIKEERMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT08</accession>
    <name>A0A2R6NT08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000862">
        <property type="protein sequence ID" value="PSR76099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT08"/>
    <dbReference type="STRING" id="98765.A0A2R6NT08"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR76099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="24509" checksum="5F498F6F8D5D43FE" modified="2018-06-20" version="1">MSGSKLSVSSVRGSIKELLADANGEKKRNFVETIELQIGLKNYDPQRDKRFSGTVKLPNVPRPRMSICILADAADIDRAKQIDLEYMSVDDLKKLNKNKKLVKKLAKKYDAFLSSETLIKQIPRLLGPGLSKAGKFPTPVSHAEDLQNKITEVRSTIKFQLKKVLCLGVAVGHVHMTEDQVLGNVMLSINFLVSLLKKNWQNVKSLHIKSTMGKPVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTC1</accession>
    <name>A0A2R6NTC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000851">
        <property type="protein sequence ID" value="PSR76277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTC1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7304" checksum="9759738BE7CB409F" modified="2018-06-20" version="1" fragment="single">SKLPLLGSFLVTKHMIALASDLQANLNLSATDVPTTQDGVLPMLTGTNIIPSQYLHEVEAINPYSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUQ8</accession>
    <name>A0A2R6NUQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUQ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NUQ8"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR77088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="538" mass="59423" checksum="01464A2B99DF5F55" modified="2018-06-20" version="1">MNFAASNHAIKTFANLVELLPAVDQRKPQVLLLAGSVTPFRNDTDREMVFRQESNFYYLSGCTIPSAYLLLTFQDGTSLANNPSLQLFIPKTELADLMWSVPPPSIQEAQTLYDATLVAHTEALPEAIHQLLKAFPEAIFHTLPKGTPLFPDLAEQYSGIPLSRNARVTDEFLLAALHHARLTKDAAEVALIKKANEISSRAHEVVMRVLGQGVRGLIKKGKGAGTERPLLPGEWLIEKEAEAEALFVAFCRREGSVHQAYLPIVAASTRASTLHYCCNDKEFAWGPVKPHDHKNDNHLAHDQDKEFVPQVLLIDAGCEWDCYAADITRTMPVGNGGKFTPEARAIYELVLEMQKLSFETLEPGLHWDAIQLLCHRTLVKGFQRLGIFKSPESPGSGSWNSEEAILASGVSTAFFPHGVGHSLGMDVHDVPSASKPENNNTISGIPLGHPDFYTYLRLRLPLREGMVVTVEPGIYFSPHLLAAIRDSKHVDHEVLKKYESVGGVRIEDVVLITKEGYVNLTTVRSDVDWVEGVCSGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUV5</accession>
    <name>A0A2R6NUV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000809">
        <property type="protein sequence ID" value="PSR77191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NUV5"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR77191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="397" mass="44949" checksum="E69944DFA1FF9759" modified="2018-06-20" version="1">MQRHSFQALNSTFVVDQEYQFVKELGQGAYGCVVSAKHRRSGEGCAIKKITNINTKRILTKRCLREIKLLHHFRGHKNITCLYDMDIVFRPDNNFDEVYLYEELMEADLHAIIRSQQPLSDAHFQSFIYQTLCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGYSPGGGNPQATRGAANQGFMTEYVATRWYRAPEIMLSFANYGPAIDVWSVGCILAELLAGKPIFKGRDYVDQLNQILHYLGTPSEDTLRRVGSPRAQDYIRSLPIKPRVPFSTLFPRANPLAIDLLSQLLNFDPAKRITCEQALNHPYLAVWHDPADEPVCPSSFDFGFEDEDSIEGMKRLIVDEVHSFRAEVRQQARTGGQIRRQDSSIYGGFQLPDGPPDLPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV21</accession>
    <name>A0A2R6NV21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV21"/>
    <dbReference type="OrthoDB" id="2745278at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="35773" checksum="FF0C2C15461818C1" modified="2018-06-20" version="1">MPCGSKTQMPSVEDRYRTSQEKGEQLNRQLLELTEALRLFRMIEENEKAITKELESRLARAELECDLSYSSQFSFDGRDTLCSWREGKILDDVIEVFGVDIKDLTSIPTILSPNKQVELAGVLQALPDRPASREEQPVPKGSSKKTIPDFWKQMIVSLTPNVSLNDICRMKSPSAPRGHSEEEQVSLSDQTTNPAAPLIPAELKASAETKKRPKRVLALERAKREAAVNLKALPHKARRKLKSSRAPGTASKKSLAYTGNAIRSMANGLGTIGARWNSDKFRGERLHESETWPDALHNYLTASSSRPVQRDVLVGSDVYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVC1</accession>
    <name>A0A2R6NVC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVC1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35017" checksum="DFCA2632428ED94F" modified="2018-06-20" version="1">MEHHWQINLDGTILFPEIIDIVLGQLVSDHPTNSMEDFGSKQYLRTSALVCRLWRDLARPHLFRDMSLSLYGFVPPEDLIWRIPPHRLKPGGFKTFTMLHDLLEQSSSICACVHSLRITMLSDPIAASDGEFETADDPSPFTFLSVVQLLPNLRNLQLCDLLLNRWAFLDTDVLDVAQKMPRLERLSVGYPVRQVDATEVIALLLLFFHSANELYLAPFRCNPTRRYRRIGNASLRLQVRSLVIDAVDPDGHFVEAFRSSPPNLQILHAGPINSRGFESLKSLIDDISMVVSHLGLDLGDPTHRFIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVG9</accession>
    <name>A0A2R6NVG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000808">
        <property type="protein sequence ID" value="PSR77200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVG9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="448" mass="50452" checksum="910A2C2BA7A9CD8C" modified="2018-06-20" version="1">MADMTQSELEDATLSPYRWQSLISRRFGEIGSASSYPLSIHELRPPLLNDNSGGSQTDRLVPPVLKSFALTPGGQYLFASMQMGDKDAGMLHVWDLGNKPLSEGSPPKIIASLSLDGIHTDLQTHIVEDELISCAMFIRDRLQLYIYHLDPDAGELKEVSSLISTSLTEIWSIDQMGDFATFFKGDLVALGQFEVVLLWEFSQNKALFCDIDRYHINQIYSFGHILVSWEDTGDHFDGGTLVFFHMPELVAIVGPSGEVEWRDVIIHQENVVNPFKFASHSWPFFSFQLNSCDLLVSATGESIHDLIVGQYRISSANNEPSRVEQIQNLVLYDNIGGDRLFFGYSWEGRCYGGAPIRFLDDSVLLPGYFYRADECKIQAILVKQSGVCVEGELWCSDSSCRASDRVQWRMPPSYEYIEDILFKMDALSGRACIHFHGGLQIIDYNVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVN8</accession>
    <name>A0A2R6NVN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCAS3 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000785">
        <property type="protein sequence ID" value="PSR77680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVN8"/>
    <dbReference type="STRING" id="98765.A0A2R6NVN8"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048382">
        <property type="entry name" value="BCAS3_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21034">
        <property type="entry name" value="BCAS3_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCAS3 WD40" evidence="2">
        <location>
            <begin position="510"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="989" mass="107241" checksum="81B165B5D45B212B" modified="2018-06-20" version="1">MRGYNAESTNYKHQGGDGSSEHEHHRGLLGWENERKGVEEMDEAVFDLDEEAHANTGTKLNSTTRYPSSDKGEAIVSASWGKLVEGARSRRILMLGYRTGLQIWDCSSLGSVSEVLNLAGPEWGAVEMIEILPDPRPSASDDAFASHRPLIGILAKSEDRSLLVYSLRTHEVIRKLSIPHLVSFSASSEFLALSTSQPATLHILSSRTLQTLHILQSVSLMPFAHPSPEMNHPVSLLNVDHEADTYSQREHLTTIPQPIFALSQGLLAFASSPPRPESPSHTSSRTPRAANQADSDNGIFRLPTTQAEFGTAAVKIGGSVLSGMKALGGMAFSAARAGVSAAVSSEYGQSRTSNATPLTSGKFYSRSAPESSGHTRRYSTSAISNSGSQGDANSPGPVEAKNLSSSKEHGHYITVLDLRPLHAASIMPSPTVVAEFMVSRHQPISAVQFSADGTSLVVTPKDGQTMKVYKLRPTENVPQMHRRDAKTCEDTRHAEDGLYASINDLIYSSAPWHIYDLRRGRTSAVVERLDWATDGRWLAVSSHKRTIHLFALNPYGGPTDERSHLDGKVVNISEPQPLSTPLVPVERLRLPVTHPEDRVSAPPAFTFIPATGPLPLALAPQPPLNPQSVSSSPSSTHSNTLSSARHSETVSHQDILVFDPSDGALSLRRVILSRRTRDDVSSSLRAVSMPGASISLPGISTIGRPATASLASPSAVRQPSGITRMMEKPTDLVAQNTVVATWALRRAMDWQIIKRSFRPRQAKRTPSRLNKSDYHFDLPANKIDVRKQVEVCATNGAMSELFVSGSSLPSQSGFSSSFDEPLASALSAELRYLNSSPPIPMYPNGPTRSSGRPAIPIRNVAAGISDGMTEGLGRLRREIGKVRSPRLAPRGGGISSSVPLEFDEEDEDFLGLDIPSVANHAISRSTSREADYISTPSTGMEPLPTEREGDVMWRGWEAEDKQAVEEVEQFDDIGVGFMDEEWIKGTGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW37</accession>
    <name>A0A2R6NW37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v7799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW37"/>
    <dbReference type="STRING" id="98765.A0A2R6NW37"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="255"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="628"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR77609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="674" mass="73877" checksum="E842772BE87CF96B" modified="2018-06-20" version="1">MSADQQLALTRATRGESSHLSRAARGVVPPFLQKLYEIVNDPKNEELIRWSDNGDSFYVLNHERFAREVLGRWFKHQKFTSFVRQLNMYGFHKIPQLQQGVLRGDSDTEAWHFEHPHFHRGQPDLLCFIQRKKPAHGPADDIDLHDPAAPPALQTNLTAGQVLDINTIMNGISAIKRHQQAISSDLNELKSSNQHLWQEALAARERHKKHQDTINRILKFLAGVFGHNADTVKHDGSHDGTIPRKRQRLLIGDVNGEEKRKSAVEEVEDDEDRRSVRSDENTSATPSTPTTRFMSMDTPESSVQSPSSPSATPRDPFNSVADISARFSSFSSLPPVRPPEAAAGPSFAPTRPAPPAMPAVSPPTVLQAAQGSNGTLSPSSLMAIPSNQGQQLNGDWSAALQSMLSSPAQLQRLMQALANQQNQPIPPQVPSHNDAMLDPRLTTHQVAPYDPPTYDFSRFRSELPLPSASTSHANALPPSFLGPLIPKDDEGPSLEPLVESANRLQKTYHDASEIDADVDALQYSLNSLIHGLGLDSTPTAPLENGATTPTAHTNGWQQMPPADSVASDPTADFDYDAFFNELSSRGPTENGFTDVTTNYNPNTQLDGTTIGDASTDQLAAFLDDMSDTASLRDDPLDLQPMAGNKRKSDVSELPPPLLSNDSLSMQPPKAKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWT7</accession>
    <name>A0A2R6NWT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PHLCEN_2v7346</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWT7"/>
    <dbReference type="STRING" id="98765.A0A2R6NWT7"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PSR78599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="377" mass="43419" checksum="FAA7F8D3943F11DE" modified="2018-06-20" version="1">MSQVKVSKRIRIYTAEDVTSHSSQSNCWISHSGKVYDVTSFLDDHPGGDDLIMSHAGKDVTAVMKDPTEHEHSESAFDMLEEFVVGRLGSSDNIVSDDWVPEDDFHPEQTDLGQDFEKNQFLDLRKPLLRQVWEAGFSKSYYLQQVHQPRHLNDSARLFGPSYLEVFTKTSWYVVPTLWLPIAVYLYVRSTLQFTLGNNALPLFSNDPVAPLRLLLVTSIPYSTFALTTACFLFGNLVWTILEYTLHRFLFHLDFYLPDHPAALTLHFMLHGVHHYLPMDRLRLVMPPAMFAALSYPFTRLAHLLFPAAMANGVIAGSFVFYVLYDCMHYALHHTRLPAYMKEMKRYHLAHHYKNFDLGFGVTSKIWDYVFNTVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXT1</accession>
    <name>A0A2R6NXT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000695">
        <property type="protein sequence ID" value="PSR79451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXT1"/>
    <dbReference type="STRING" id="98765.A0A2R6NXT1"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27288" checksum="7D43054C0EB19E75" modified="2018-06-20" version="1">MDLGLEDVHVLVTEQGAKVSAHYRSNPSTLGDLSSTYGPEQLLAVRADLTQEDDLIQLFEEATATFGPVQILVVNHGYWPPEDVPIARMTLNQWNSTISTDLTSSFLVIRGFLNNLEKASDSEKEKAAIVLIGSTAGKFGEAGHADYAASMMYGLTMSLKNEIVKIAPRGRVNCVAPGWVRTPMAESALQNPKIVYQALATTPLKKVAQPQDIASQIVILSSPLVSGHVTGQVVMVEGGMEGRLLNRPEDLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY36</accession>
    <name>A0A2R6NY36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v6966</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY36"/>
    <dbReference type="STRING" id="98765.A0A2R6NY36"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="13">
        <location>
            <begin position="307"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR79665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="585" mass="64071" checksum="B6FA53460B469C7A" modified="2018-06-20" version="1">MVNFAPYPTPAYNAEHYDYGGTKRHFAEDVETAGDTGVDFEDDDFEASGSKLTYPGETITSSHAFMRGHGTYVENEEVISSVAGTVERVNKLVSVRAVRSRYNPEVGDLVVGRITEVQPRRWKVDAGSRQDAVLMLSSVNLPGGVQRRKLESDELQMRTFFEEGDLLVAEVQAFFSDGAMSLHTRSLRYGKLRNGQLVIVPPVLIRRLKSHFIALPCGVDLILGLNGYVWVSKHVKESEQEGEEGFDAEAVYSNRNDKIDEATRSAVSRVSNIIRVLASHFTPLTDTVLLEAYEWAVEQEIDIKDLLQEDTVPKTVENFRALATGIKKDGTVLEEGFGYKGSKFHRVIKNFMIQGGDFTRGDGTGGKSIYGDRFADENFKLRHTSTGMLSMANAGKDTNGSQFFITTAITSWLDGKHVVFGKVIEGMEVVNAIEDVAKGRNDRPNEDVVIVDCGELAVDPPTEEEGKETSAITQSSSPALDAVATVADATEEKAAIATSVKPAADLAEPTDGTTDSTSEGDEDLTNEVEGWDFFNYILTLAVFVVLGALLWWSGAITAAGKRLGWNGGASDKYRPLSEDVEKQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYH8</accession>
    <name>A0A2R6NYH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYH8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015336095" evidence="1">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="11557" checksum="4B5A9297819482CD" modified="2018-06-20" version="1">MRHLLLTAFNLVCTIYTAVNASPLPSARDDDCTVFVPSLGDNPIFISGESNTITCIHSVIITTLGTDIDPYAGNFTFTLPAVSADPYWIACKQLKNIFVARTMSIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYW8</accession>
    <name>A0A2R6NYW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v6674</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYW8"/>
    <dbReference type="STRING" id="98765.A0A2R6NYW8"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR80758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="367" mass="40660" checksum="5BB8AE21DD4BEDC3" modified="2018-06-20" version="1">MRLATARTLFRHGFITKIALQSHSRSPLVSVVFRAYATHRDPLPTSSLLSHALDRKRGAVSKEDSVGPFRLGIPPSSQNAKDMKRWSELSAGGKVLRTTARTTNLLVILFGAGFSAMLVYALTSELFSKNSPTVLYGQACDLIKSSPKVAQYLPGSLVFHNNPPTSIRPRHRNDRVASQITRDSSGREHMLLNFFVQAKPGSYSADEDPSWYSSTVDWTKRAVSKLSEMSLDEVTDAAGQHASEVMDSCKRMFRFLTGDPLPPTQPVSSPVPEVTEEKKSRSWKSGAIGLFSVLRSSTKEPKESGNDVPDEHAYTDGEVHADLVMNDQGLYEFRYLRIDIPDSQTANPKRIFVVSSSGPGTRDSRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ89</accession>
    <name>A0A2R6NZ89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NZ89"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pre-SET" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="902"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR81130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1321" mass="141678" checksum="438ECAF79AD51E11" modified="2018-06-20" version="1">MSPLPRWEPLRGKSFKRNISKIADFDLSMRVAASSSSTTPSEDDILASSQEMRDELDQTPPSTTPPNHKRKLVDGGSSTAGPYKRSRLALSVERHLTDNGMSVIASSLPKVHSFQDGRLQATSSRAVQLPSTQPLPRRPPAALTEKPTRGVPPLPPRSPPVVSRSPVASGSIFATKPHLSRSSTPPEPRRNVARKSTGMRPRRRINKGSGQGILPVSGLSSSAPIASGSKGESVSTSARDRDPRPSTSSTDEDLPSVGEIIRDSLKRNPPKPASDNSANAKKAKRRVTLANFSDVINLVSDGDEVSPASKVINKTRPSRRQSLPHDVIEIIDSDDEPPTYKPSKKSMSVNKTPSIPPEDVIVISDSDGDARSVGLPARGASDGGTARSGIEAGHTEPIPAVRATSVPPSIEPPQEAPLSNSSGESIPVASTVSTTTNLRKLPLFYPSDESTPPVTPPHDLSSPSTPSHGEIIPTPLSPSHGDTDMQVDVDGQYTREDQGNHFSECTPTDSPIEVPHNRLQNESPNIDTIVPALDDMAIANSTNTSVPSVDGDARLSDGGKDVVSLSVRSAAAGKAVRLSERSDEGVHHMDSSDASRPSVTPSLPFSMEGFAGPRLEGLGGDDQDSVDAASPIKPLGDVHSFKSPSSSPMRSPSRSIIPVKVRGSLYGGTGGFFKAVHRRRSSVNSPNITSGTLDPEPGPSYTHSSPPPPAATEEPAPSDALLSPLTTPQAPSPDANAATESPSAPPTSSELMQTSLTDVIPDVQAAVSGVPLQFPVMRSHSGHKQEKSAQSALKATLINASFKVAEVSHSYIDLTISDSEDDYTRPAREADEAAALESTKRLAALLPDVLADTPPKIGPAHPDSLRASAALEARPGVEPTGSSAPRLDKIRFFMPRTLGKARQNDTQFRAPIPAQGESYPDPGKDPQHSDNAEDIYAENSTVSVTSKRLRDTLPFYESRVLPLRLPISPEKSVTPGEDDEDERQCASMLLDSDTSDSINDNTILESMNHSSPIEMTMTDEVWSVPRSLSTRTGLRRNPERASSRRSSSSASSLSLPDPPAHRGSNPRIQAPRTYSGVSNILVPALDQVHIDGLELDVYSWKKSGADLAMEFANVYALARDLPHDAQDRVNSLDDVARRGSQLILFESLMSENTASDEPGAPDIKVINDVDDELTPPFEFHYSNLMWHSDNVPRPDLDHLRSCECHGSCSADAKKCACVVRQQEAYIAGGYTTTTGFVYDARGKLRSELHSFPIFECNAFCGCDDRCRNRVVQHGRKLRINIQKTVNKGWGIFADERIPANTFVGIYAGEYLTDAEGNERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZC0</accession>
    <name>A0A2R6NZC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v6509</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZC0"/>
    <dbReference type="STRING" id="98765.A0A2R6NZC0"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR81174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="497" mass="54169" checksum="F6E47D50F6D507D0" modified="2018-06-20" version="1">MVNTFNSPNYHTSTASVMANTQDLPPTYDAAVTSEVHSSGPFVPAGTGDVKDVKVPMPTPDANASSPGAGPTPFSPPSMPPTTVYNYVNPVTHEVVTSLLPPDHPRMVCLQQGHDPHSKFGFLDVLSDLEIRGLISQVSSPESLRKAIKQRQVVYLGVDPTAKYLHVGHLLPLLCLFHFQVRGHGIIPLIGGATGLVGDPSGRNTERPLSEASIVANNVEHLASGLNRFFEGAVQYASKRLAASTRTISPPEIQNNLNWFRNMGLLDVQIRLNSQQGISFTEFTYQLLQAYDFYTLHKDHSCTIQLGGSDQWGNILAGIDLINKLNPDVASDGSHIDKVFGITMPLLTTPSGEKFGKSAGNAVALDDSITSVFDFYQFFLRVPDSHVGQYLKMFTLLPVAEIEDVLCQHQQNPEARAAQRLLSTEVTELVHGEEAVSRAQAATKVLYERDLAEVKATDIIMALKGDPRLQFCEESELLDAPVAKLAGRYKLVVSNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P144</accession>
    <name>A0A2R6P144_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000584">
        <property type="protein sequence ID" value="PSR82476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P144"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="227" mass="23288" checksum="0D13F882206BE73B" modified="2018-06-20" version="1" fragment="single">MKTRRTTTPAYPINSETTNGETQGVSVGSSQQAVTAAVIGHVFAGLNEEGTADVVSEAGTVHSTMSPCLPAPASPAPPPLLPTTQATPSCTSIIPLPSRPSTPPRASEPLPPPPLTPAKASNTVTSLTASTALQPSPPSTPVKALTGSSPSDSMATTPSTRSTASSSSSMPSTPSTDPLTARMESFREDMLTDANPNVFYLGDPNFDPRTALTWVTCDSVNILVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1C2</accession>
    <name>A0A2R6P1C2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1C2"/>
    <dbReference type="STRING" id="98765.A0A2R6P1C2"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="141"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="224"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR83152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="480" mass="50447" checksum="6C79E9510BED124F" modified="2018-06-20" version="1">MSDLDADLYGDLYGNDDPEFALPTEQPEAPPKVEVSESSMTVKTEPPPSRPITTQIPNIQTSSTPPKPEPSASPVDNISQQIPTSNGTGSPTYGMGQTQQIPTYQDRETPEYREVPQPAAGAGYQGAINRPVRPSEMKEEGKMFIGGLNWDTSDESLRKYFSQFGKVEACTIMRDAAGRSRCFAFLTFEDPQSVNAVMVREHFLDGKIIDPKRAIPRQEHQRATKLFIGGLAGSVTSESMREFFSQFGKVVDATVMLDRETGRSKGFGFVSFENANVEPLLGFGNLEIDGKVIDVKLAQPRSQREGGFQEGGATGGRAAAYNAGGFQSPNGFNAGAAAATPAAGGSAPFDPQALASLYTRMLSQMGGMNPMMGGGMNPMMGGMQGFGGPMGPGAMRMPGMPGMGTPMAAAGMMGNVGMGIGGPGMGMRGAPGMGAPGMMNGMNPNIPRGPRGAPTGPGGAVGPQRAGQRGQHNYHPYARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1G7</accession>
    <name>A0A2R6P1G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000563">
        <property type="protein sequence ID" value="PSR83275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1G7"/>
    <dbReference type="OrthoDB" id="2804213at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="12270" checksum="09201975EC6F9BF6" modified="2018-06-20" version="1">MHSVLLAMNIAQVALKAVNPSLTPILISRFLLNLRQLGEPENETQSRFNFRFSIPGFRVPTLESIVGNMGADLDHGPAGEVDDDEAEEADVNGGDAGVAVLDAIAAAGSGGACHGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1V2</accession>
    <name>A0A2R6P1V2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000552">
        <property type="protein sequence ID" value="PSR83738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1V2"/>
    <dbReference type="STRING" id="98765.A0A2R6P1V2"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="772" mass="87337" checksum="8D74C960867ADEB1" modified="2018-06-20" version="1">MRQVRRLSTKLLRRNQALFEDLTRPLNEKQKKVAEKEHLKTLPKFNSSLTKKPRKAERQKIHEHPQDIVQQRFGDGFTLEDVIMRQYVWDIEIAPFESVVVDKNCPNKSNAGVENARVLLPCGCTAGTHLLEGPDNPSILSTILRQEGFGGYLRFPRHNVLGPISPVKIATRYAAERCKYRNPIVQGPVMSTKDHAEDVQTPSLAYFTNKVSGARGLLKAGYSLSHVFSTALDNKHGQVEDVDVVGSRREGMPSVQIRGYHTSAMRRTDVFALSQVPAPVLQQRAQAVQRIEGAIQGCFGRKYRVKLFGSTCYGADSAASDLDLVIIDPDHPTGFPPKLKMYKLPIKFIDPVSKLACDLNVNERLGYRNTSMIKQYCAISPLLREVITFIKYWAKPLGLNDPSGQDGPRTFSSYALTLMTIGLFQSWGLLPNLQHGLKPLPEDPIVGVFWTRLKKDVRLRCDVRFNVGQNWAPQRAMNLQDALRQWFDYWGNEHQYEDTMVDIRLGGVRPRFTQRKVDDQIIQYRDSSRDSPVATHCPGGWSDEKRIPSELQDEVVNSFLKKASIVLPSSPPEEFDEPLDLPSWIKWASDPLCVPDPFITSKNVVSGVGPSHISRFREDCRRVVKLLDNGQPLEAFVEGFVPFQKAAADVESREALRTLFEPDGRRLRLQALQAEARKLEARHREVQAGIKFIPGDSRAVLVQLRKMLNRNPTEGEVVKEGSIETVVGSVRKPEPTDAEPRITVPTTKARRHRMRKRMRAEATAREPQPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5Y6</accession>
    <name>A0A2R6P5Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000528">
        <property type="protein sequence ID" value="PSR85656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5Y6"/>
    <dbReference type="STRING" id="98765.A0A2R6P5Y6"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="261" mass="28419" checksum="5F9B26242D53623B" modified="2018-06-20" version="1" fragment="single">QIEYIGPWYPLTSLNSSTHNGTITGVNRPGAFSLTFFGSHVSVWGTLRGMNYTLPTPTESSYSIDGVVNPNYTALQGTEEIDNVLFFDSGDIGTSIHKIIVTVISATPSFPYYLDYITVVSPTNSTSTALSQITIISTTTLLQPATLSQIPVTYTASDIPSQSTVSSLRPNSTSSHVAVGAIVGDGMPGSGREWSILTVQMKWCHLRHLENTMRPLIPITNMRAKPLCQWSAVLPSKRAASQAFKKSCGTMIPMNHYRIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8R3</accession>
    <name>A0A2R6P8R3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8R3"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR87355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="9694" checksum="ED44A8BCD97EB44C" modified="2018-06-20" version="1">MSQGPSQAEIVTAFQGLLLDNYIAYAMTALAAYEYTITVKQEMTMVWQHRWTLVAWIFMANRYVMIGIVIWTVAPETAKTGIFAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGQ0</accession>
    <name>A0A2R6PGQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGQ0"/>
    <dbReference type="STRING" id="98765.A0A2R6PGQ0"/>
    <dbReference type="OrthoDB" id="3207945at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="8050" checksum="3540AC1A9DC1337E" modified="2018-06-20" version="1">MDAMSKVSRLPTSGSTIQLYNNCADLLTLPRTQDVLCTSRDCPIFYMRKKAQKDVEDASAVLERFDYELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN14</accession>
    <name>A0A2R6PN14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylenetetrahydrofolate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN14"/>
    <dbReference type="STRING" id="98765.A0A2R6PN14"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000401">
        <property type="entry name" value="Related to MTD1-methylenetetrahydrofolate dehydrogenase (NAD+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="1">
        <location>
            <begin position="13"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="2">
        <location>
            <begin position="188"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR93812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44075" checksum="F48A27F51EBC3B9C" modified="2018-06-20" version="1">MATNNGGKGILLKADPIASAFRDEIKTSLDGARPPKLVGILATSAAPSKFYAEFTKKQCEDLGVNFVLNKIGAAEDPSKSEGEGVEEAIIEANNDDTVDGIMVYYPIFGVQQVGNSPDTTIEISSAKLLYCLGSLSPAGEPTSEMREILTFIRYLKPDSLLSSLTPKEPPPPVVDDAAPAGYVKSILPCTPLAIVKCLEYTRVYNTILPYGDRAYGKTITVINRSEVVGRPLAALLANDGARVLSVDIDSIQEYNKRPRQSTESDQGQAKYHPHHVVSPCSLSLQECLAQSDVIVSAVPSASYKVKTEWLKDGCICLNVAADKNFDKDVREKVTSPFIPRDTERHDERLEAAKHGLHKSSKFVLDHVLQYWRNVDRQLAKTQILFLFVHKKSHQWLRYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PPC2</accession>
    <name>A0A2R6PPC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000447">
        <property type="protein sequence ID" value="PSR94556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PPC2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="368" mass="41232" checksum="0F6D6149970F0983" modified="2018-06-20" version="1">MPLSRSRTEVRERSIDQNTLKAWKKSRDRLWWRWLKWRYDFTTIHVDTFDESKPPTGGAKEPWLIRRLLSFLRHTNGIGDGVKELTLRGHPEGAHFEPPNLGTNALFRILVLLPELRSLRIIGYDHDSIVTRPPRRKPFGPQHGDSPPDLSHIREVFCATSARRLLSELQGSQSIRVLQLDEAVYDDHLRWNRPADLGATFDALNRLGQARNELEQLGLYVGGSDITSLKDLPLDFPKLETLIIMTDVHPFSILHDRVDPLRVRIKLSRTSDPPVTFPRPPCEQDINATVNAPGLKNLQSTATGVQVMKSFFVLASFVAACLGQGINIAAPLANSTVSPGQTITVEIDRPVCLGILVVQYGPTDSALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PV89</accession>
    <name>A0A2R6PV89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Piwi-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PV89"/>
    <dbReference type="STRING" id="98765.A0A2R6PV89"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="323"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="605"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR97101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="107780" checksum="E799A19DCD29303F" modified="2018-06-20" version="1">MLTSHSSCTLIVRLKKAQIIATLQISVRNRRFITTCNRLLRSGKNPFLIGPSASANPEASPIAGGNRRGGRDSRERRVRGSDENVGPTVESSQALIAAFEREPHTDEMPLRPGWGTNGKAISLQANFFALKLPSDLTIFDYEVSITPEVGLWGPRKARIFELFQGNPLCAPYLGCIAYDNSGRLVSSKMLPQPFSLTIPFFEEGVSGPRPNAQVYTVQAKFLRALDTNEVNQYLQGLPSYRDRDISPFISALNLVLQQHASTTGVRVGQNRYFFPETERHGIALGLQTWKGFFLSVRPVYKQLMANVNVSATPSYAPGNLAVLMAEWNQKNENMPKWFFDKLTIATTHLGYQRKHRIHRVMSTTARHTEFSCAEMGGMVSVERYFQQKYKIKLRYADTLPVIDVGANAPVYLPAEVCEIIPYQPFRGKLPAQASASMVKISTRSSASNANSIINDGLRLFGLQDHNPTLMNFGISVRKEMAIVPARVLPPPRILYQSGHLVVRQGGWNLIDVKFCAPGRIDNWVVLLVRDGRKEEFNGVDDPRLQDFLQMFLLQCQSSGISIGRGLPAIITTPPLPRANANRQDAVAVIAKALKDGLNNKQKPSVMLVLLPDKSLYTGLKRLCDVQLGIHTVCMFVKTARELKGRQRYFANVALKLNSKLGGINHSLDTQSMRWLTEKKTMTVGIDVTHPSSMSMKGMPSIAAVVANADDKFAQFPASLRLQTNRNVMKDGEEMVQDLTSMLVERLTLYKKNVGALPKRVIVYRDGVSESQYNLVNQKELPQILKAFETFNAGQKYRPSLSIVVCGKRHHARFPGTSAVHMTKNGNTLPGTVVDQGVTDIFNFDFYLQAHDGLQGTVRPTHYTIVYDENQLSADAIQTGIHHASYMYARATKAVSLVPPAYYADLACERARRYLAPLFDPDKAGSTLSTKGANGQEDSETGRKKVYDRAVQMWGNGVHQDLKDSMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVK4</accession>
    <name>A0A2R6PVK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000441">
        <property type="protein sequence ID" value="PSR97278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVK4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5771" checksum="BE95EA6535098592" modified="2018-06-20" version="1">MFGQPRETNRVHRGSGQSRRKPKGSKTFANEQNESDTAQSTGATIWRDHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ73</accession>
    <name>A0A2R6PZ73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000418">
        <property type="protein sequence ID" value="PSR99449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ73"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ73"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR99449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="343" mass="38600" checksum="97462D24E4D6EF75" modified="2018-06-20" version="1">MSQNKKLILVIGATGAQGLAVIDALLAPQADGSPSPYAVRALTRNPDHHRAVDDFAAVAAALEGTYGVWVNTDGFTLGEQKEIFVGMRIFEIAKQTSSLRHYVWSNLDYISKETGYNPRYRCEHYDGKGRVTDWLQAQNSDVSDTGLSWSVVTSGPYMDMLNNIMFGPLNQRADGTFVFATPVGNGHVPMIALADLGFFARYTFDHRAETSRQDLKIASDVVGWDYLVSTFTKVTGQKAVALYQSPDEWFDNFHHTDRPVATDRQKGDGTTTWKQNFLGWWAIYHDDAIKRDMDWVRRINPNTRDLEAWMRETNYTGKLNFDTLKGTEDAGDHAINVERISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5D4</accession>
    <name>A0A2R6Q5D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000398">
        <property type="protein sequence ID" value="PSS02344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5D4"/>
    <dbReference type="OrthoDB" id="2332199at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="27246" checksum="A8A2B8E40515949A" modified="2018-06-20" version="1">MGNEVSTARYMAVGSFLVNFGTQTYGMLIKPNMKDIADANHFAFSPNPWFIAAFFSGQTALQLYWIRELFLLDDSNNTEGTTAATEAAHVAIAYAPIYAVGNLCIAGWLLFWLRQSFSLSQILVTVNTTAQLFAVARLPPLKRDSPRLLWVTHLVAKTFAGIGILDFVDNGGVAMHHRAPPSTLAQALTYSLFPIVAAASGPIFGSTLVYDLLAMYVGQRGVAGAEAWSARLGWTALAVGGIVGWKGLLSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBQ7</accession>
    <name>A0A2R6QBQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000366">
        <property type="protein sequence ID" value="PSS05556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBQ7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="285" mass="31309" checksum="CBA18EF3A835E515" modified="2018-06-20" version="1">MAYIPTGNPNEYLARLLTRDNYTSLYECQLHNGPTADCEGCGRHAAALVRDAQARLLGGLGKRASYIEQPGSNKGPFAARNGWEGRTKTRTISNASSNTLVSSSSDSMSLERDVRRSGREAVTRVEKDAYQLPTTACAVVHAPKPEVPRLISWLADSQRSRLDFVAQPGPIGRPGLTAYASPSSDVTDIDEDSTGWEERRYTKDLVDDEDEIIPFHRKTNCSWPTVRYTRVSDANHYKAMATRTAGLLRLLVGSPHNDTALEFNATFTGVTSEACELDFSTAEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEB8</accession>
    <name>A0A2R6QEB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000364">
        <property type="protein sequence ID" value="PSS06498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEB8"/>
    <dbReference type="STRING" id="98765.A0A2R6QEB8"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF119">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS06498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="194" mass="20995" checksum="FB4A59005859767C" modified="2018-06-20" version="1">MSLAIPSDDEKDDLLLACRYGDLEDIEQFVNKFGPDAINDIRDHSGNTVLHMVCANGHAVSSSLLSVQNEAKSSPLHWAAMNSHLSVCQKLVQHPKGPGIDLIDIKNAAGRSPLGEAENVGWEEGAKWFVEVMNLDEGAKGEEELRPADDVQNIEVEIQDAEGQVAKMKIGPSGPTVNPLANSLRNCKSSTRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF79</accession>
    <name>A0A2R6QF79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000343">
        <property type="protein sequence ID" value="PSS07211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QF79"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS07211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6468" checksum="3359A4D5A778B65F" modified="2018-06-20" version="1" fragment="single">RAYIATQTLAGPPDTCKPYPEPPPSVARQGHQTSSKRRAKTWRDDQERKILYICRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUH5</accession>
    <name>A0A2R6QUH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000315">
        <property type="protein sequence ID" value="PSS14755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUH5"/>
    <dbReference type="STRING" id="98765.A0A2R6QUH5"/>
    <dbReference type="OrthoDB" id="3228837at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="379"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS14755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="864" mass="95517" checksum="CC0DC680ED98A99A" modified="2018-06-20" version="1">MDGVGATSRDGTLLRLDVLQVKVIGQDRLPRDIEGKEFHKRRFYVEFKIGGTKKKTKDCSGKGQLAWIEAVPFVNVDSSSIFEAAIHAKRSSLFVHDAVKIGSLSDSVESFLPPSDSLDTPRIVTRVLDLYPDVQLELHIKATTAASLGGDTEAAIRNFAKPVQELTGSHLPEIPADVASAAAGTGQTVGKLLLPALKKIKSFCDAMNSISEILNNQLKRNDKIRALFVKMDSFYTVVSKYLMSRLGGVRRSSLIAILQRISVMTMECCSFIWSYASKLDESGFVEGTLENSVSSNNDRIETYCNIFDSLQQDFRNAIRVDKHHIVERMAEYASLGDMPHVKGASLNAEGSCQEGTRKAILGVVSDWISPGSKSSGHQPILLLTGEAGTGKSAIACSVAVEFAALGCSFGFKRGIKERCNLLNLFPTIARDLAHFDDSFRRALCAGVGNDKALQITSSLELQFQHFIKNPMAGISRPILVVIDALDECGDAEDGAQRAALLKLLSTPGKLPSNLRFFITSRPEPDIRSHFEDLNKDHIMIKHMSEIPTDSTSADISLYIRTRLISDFQSKLEGIDEACCQTLARTSQGLFQWAYVACKQIAYPPPGRTPLEHYKKLVQSGTGVGQDKLLDYLYLEAISASFSENDEEGMLVERFKSVLAVVLASFEPLTMAGVKAIHKTLKQPDEYYTAGDILQHLGSLLSGVNDTDVPIRPLHTSFRDFLTDRTRSDSLCVDIAGAHRSLTLASLYIMTKELRFKLESSYVMNEDILDLPMLIQNCVPEHLSYSCRFWACHLDIALPNGQPLEPEISHQIRELLEMFVHRKILFWLEVLSVLDAVDLAFPALAIVARVFKIVSSVFLFLFCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R107</accession>
    <name>A0A2R6R107_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3145</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R107"/>
    <dbReference type="STRING" id="98765.A0A2R6R107"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS18929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="403" mass="44288" checksum="0CC6B9CD2FAAF3CA" modified="2018-06-20" version="1">MSSTKVIVAGAGIAGPVLSIFLKRNGYDPILCERTEGVSDAGLSLCLQPNGLSVLAKIPGLVESLVGGSIEKRVFYSVLPEDKGILGESDIAKQLQEEHGVGIVLGVRRTVFHQALVEAAQKAGVQIKWGHKLVSLDQHDESVTVKFENGVEETASFVIGCDGLHSNTRICLFGDEKADFTGLVQTGGIYAIPQSKNAPNSRMIDIFGNGTHMISYPINDKQCVWVATRREPEAKETWRAMGIDNAEEFKKSSLYVEWDYGGGEMVKSTDASVIIKYGLYDRPELKRWHKQRVCLLGDAAHPTSPHLGQGANQAFEDIDILISLLAKYNPIPHSPPTQVLENIFSELEKARIPRSSDLVKKARLQGESRVTEGVEACIKRNNTYRDICKDQESVGRFNVGQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7F3</accession>
    <name>A0A2R6R7F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000267">
        <property type="protein sequence ID" value="PSS22701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7F3"/>
    <dbReference type="STRING" id="98765.A0A2R6R7F3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS22701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="699" mass="78634" checksum="0BAE60A89E4A8C2E" modified="2018-06-20" version="1">MADGASAIIGIVAFGLHAMHRVYEIIDNVKDAPADILALRQDANDVGNLLLQLQKSVMDSSVVPQRSALTDRYMDALSEIESFIDKVAGEQRDGEIQVKKLQWYLKNGRCEKLRRNLSSLKTSTIAIVAASTLTFVYDLQNTIIQLVESQDRLANAQEQSCALIDAFQSEHESWCAQQLAELANLRVLVEALLARDRDRVFFTLASSSGATQPPCNSGAPPAVSMPVSAPDIPISEICEAFTEDKHHGQTSQRASLVPRTLKPLTKSDLKRTLQCENPCACCCHDTRLTRATPYWGSSWFGNLYLPRSFFHRSFASCNVQTCRRMQKSCQLAKIKFFFPSWFLSVEMKIRLEAFPVHFYLQTPRRVPNMSPIFRCVVRMDIEGVRKLLVSGEASVNDVNEEGWGVLHFAVRHISNHSCEQVSAMLQFLVDEGAHTEWEEEQFHRTPLRLLQQHGSLQLQKPDIEGSVVRSVQVQIAGPIFHEDLVDAWEDWLEESDFTDVHRAVLTHRTRDVCLKDRLVGTPVADISAPCRIGMTPLDWGMFMDVPDVVQTLLDCGADVHKGYPLHRAAFWGDVQALKYLVHAGADMYLQDNRGRTPLHEAAYYGKAEYVEELVRMGADILGLDILAQYGDTVLDEVSAGRRYFDAMSRLTYGHDEVVRVLSNLQAWRDSRSTLRHSREPNTEVEVLDDLQMPGSFPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI05</accession>
    <name>A0A2R6RI05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI05"/>
    <dbReference type="STRING" id="98765.A0A2R6RI05"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="104"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS29652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="499" mass="56621" checksum="7C6ECB5B510B7327" modified="2018-06-20" version="1">MSTLPVSATRASYSLDDKDEHGFTIAEEILEAAEPRTRKRSFFSRGAQKDLDGTATQPSVFDDPTTRELYRPPPEYENTHRFDPAARWTWREEIRIVRKVDLRVALWAFIMFFSLDLDRSNISQANTDNFLQDLGMNTDDFNLGNTLFRLCFLIAELPSQLVSKKVGPDVWIPCQMVLWSIISLSQYWLTGRGSFLATRCLLGFAQGGFIPDVVLYLSYYYTTSELPIRLAWFWVSNYVASIVGAFLATGLLRLRGVRGVAGWRYLFLIEGGLTLIVGLLSFLMMPPGPTQTKAWYRPNGWFTEREETIMVNRVLRDDPTKSDMHNRQGLSIKMIFSVIKDWKMWPIYCLGIVHMIPVTPPQTYLTLSLRNLGFSTTQTNLLSIPSTVLGGITLLLASYFSEIVNSRVAATVILQFWALPLLVALYTFNEQTSNWAYYAVVTLITGFPYVHPVQVAWASTNSSSVQTRTISASIYNMFVQAGAMVGANVYRDDDKVRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI40</accession>
    <name>A0A2R6RI40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI40"/>
    <dbReference type="STRING" id="98765.A0A2R6RI40"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="326"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="174"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS29675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="549" mass="61527" checksum="90BCC44B2642900A" modified="2018-06-20" version="1">MGPFNTWSQSPSTTPGPLPKQQQPRSSSSSQASKDKPKKPRHRHSAFQLAALNELYDKDEHPPLEERTSLAERLGMEVKTVNAWFQNKRASSKKRSNKGASNAQYELPSISTLLASVPPPSSQLEYDELSEDEHPFADRLAPISSSHDHPRAQSLFYAGNPQHRHLFENESNSPRKGRSRPSAAQTEELRKLYDQNHHPSKEEREELGDRIGMRYQSVTNWFQNQRSIAKKRREEEEAQAASAKELERATSSRRAAQSYPSFPPSSSVAHPSLSVPPTKGHPSLPSLPFTHHSLRSPSIAPTADSRASSPRPSPYGTALTERSSSAHARSRRSRPEPYQLEALKKLFQRTSTPSIEERGALALEINMDVGKVTNWFRNLRQTSRRRSKRGSEFEDDDDDMSVSAYQDFSRNGSRAASPAQSSSSASSDRDTRMDMDHGYPDHVSLRVKLETEEKHHRLYTHASNSRSSDMASEEDFQEAVTPSPASSPFPAFPRAVQKPAHAPQPRRDLSFTLGALSYAEMEKASSQFNTGVKVEDALLLLSFHHHVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIC6</accession>
    <name>A0A2R6RIC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIC6"/>
    <dbReference type="STRING" id="98765.A0A2R6RIC6"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS29765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="141" mass="15797" checksum="7845F49346339969" modified="2018-06-20" version="1">MLVSLQGPEHKGALLFANYIVLTFGSCFGVIYAYNASNTSGHTKKVTVNAMTLAAFALGNMIGAETFLPQDAPNYIPGKVTLLVFLSTQIFLCLLLRYINLNLNMKKARLVELLKERNNWSDPDVAKERERHAFLDMTDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIK1</accession>
    <name>A0A2R6RIK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">valine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v2643</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000249">
        <property type="protein sequence ID" value="PSS29850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIK1"/>
    <dbReference type="STRING" id="98765.A0A2R6RIK1"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000010">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000008">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="15">
        <location>
            <begin position="107"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="777"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSS29850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119519" checksum="40B2F64082BDBD23" modified="2018-06-20" version="1">MSQAAPPLGKPAPAEDTTPSNDAATSKSGERKKAKRLEKEAKLALKVAMNVASGQNTPTGEKKAKVEKKKEEEEVPFVNTTPKGEKKDLSEPMSATGYNPIAVESAWYDWWEAQGFFRPQMTPSGDVKPEGLFVIPSPPPNVTGTLHIGHALTVAIQDTLTRWNRMLGKTTLFVPGFDHAGISTQSVVEKRLWKAKGQTRHDLGREKFVDTVWEWKNDYQNRITDQLRRLGGSYDWDRVAFTMNESLSKAVVETFCRLHEDGTLYRANRMVNWCVRLNTTLSNLEVDQMQLTGRTLLNVPGYDAKEKFEFGVLTSFAYPIEGSDEKLIIATTRPETMLGDTAIAVHPDDPRYTHLHGKFAIHPFLDRRIPIITDSIVVDMAFGTGAVKITPAHDPNDYEVGMRHKLEFINILNDDGTFNDNAGEKFKGMKRFHARVAVVKALQDAGLYIETKDNPMQIPVCSKSGDVIEPVLKPQWWVNCKPLAEEAIKRTRAGEMTISPKQSENEWYRWLEDIQDWCISRQLWWGHRCPAYFVRVEGLNQDRDDGKNWVVGRTLEEATERAKAIAAGAKFTLEQDEDVLDTWFSSGLWPFSIMGWPEKTLDLEKFYPSSLLETGWDIIFFWVARMALLGVHLTGQMPFKEVLCHAMIRDAHGRKMSKSLGNVIDPLDVIQGLDLEALHQKLYEGNLDDKEIAKAKSGQKKDFPKGIPQCGTDALRFALCAYSAGGRDINLEILRVEGYRKFCNKIFNATKFAMLKLDEKFVPEPTAKPTAKESIVERWILHKFNIAADEVNRQLASRNFMMATSAAYNFWLYELCDVYIEAMKPMTDESASPERRTSAQQTLYTCLDYGLRLLHPFMPFVTEELWQRLPRRPNDSTPSIMVSSYPVFDQSFIFEDAEGDFDLVLKVLKSGRSLAASYSLQTDIQFFIRVQSDVEGKLFESQASTIVTLTKGCKSAKIVRELSEVPDGCGSVVISPTVVVHVLVRGLVDLDVEIDKCDKKLRLAQMSLQKIQKMESQPDYEETAPANAKLANEDRRKTLEVDIENLELSKAMFAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM00</accession>
    <name>A0A2R6RM00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000224">
        <property type="protein sequence ID" value="PSS31005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM00"/>
    <dbReference type="STRING" id="98765.A0A2R6RM00"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VASt" evidence="6">
        <location>
            <begin position="567"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS31005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="931" mass="101335" checksum="4133C2543AEFFA35" modified="2018-06-20" version="1">MAPNFFSKLVKTNTHREGARSPSPSPTSHQPTISVSRPSTTHKPSISLSSSIQPSDNDSDTTSINPNVTVIPPSPRTSDTSMMSNGLPTPTMGNSSDNLAGSNSKPARRLHSLSLGSNPIKSPVSPPTAEDDAATPTPMRPTMSGRESTARPLSHASSTGNLREEAINGAPHHPRSATVSNGNYERQQEHDRMLRRSPSNKSNKSTKSNRSGLRIKLKSDHSPPLPQPKADHSIIVPPHSYSEDANEEVSLIVESPTGITPRTAVHDVGPSKSSIAASQTLPNIPNSSFLAAPDNSDTVSVYSVGGTKKRRIFRRGSVKEGTSPVTPSLPSASKSPKRKNTGLASALAASGLAMVNPAIAMPQIAPVDVMARTDRSNSLNSNGYPHRSRGSVDNTRSPARSRQTSLSYATSDYSDRDSFVSGVEGGSEDDDDLDLDADDIPVTGFAVASARRNQEFHEMFPSIPEGDYLIEAFVIPNAIQVTTRGAKYTFTSFLSRDTTFDVIYNVWRLARPENSSIGSALPSARASLDTSNDSTEGASAVVAVNGKLKAKGQNKVTQCACGKASQHYSEIAMESVLPGTPEKIYNLMFASGFIKEFMRVDQKLMDIQISDWIPLPDNSTLLSRNMSYIKPLSGSIGPKQTKCELRDEIAHCDFEEYVSMLTTTRTPDVPSGSVFSVKTRTCIMWASSVSTRIIVSTQVEWTGRSFIKGIIEKSCIDGQKTYHAELEKGMRDYIHSHQSEFIPEGVDPAVVEEAEAQVAAESPGTPALDVNEEQARKVREKERNQRGLQWAYDTFEGAMKVAKQSTEGALELIKDAWDQSSSSTIQYFVIVLLVISNIWTLTTMGRQEEVGRRKEIRRTEDREKWVQGVVTALWDELTNTKAEVIDLPVPSLAVLRASTNDVKAEVAELNNVLDKVEERVRIIRGSLQDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM35</accession>
    <name>A0A2R6RM35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM35"/>
    <dbReference type="STRING" id="98765.A0A2R6RM35"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS31090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="33469" checksum="9C65D3CE55A757A5" modified="2018-06-20" version="1">MAGLSVALNDGSHMPWLAFGSGTSLRDKDASKQISNAIKAGFVHIDCAQMYANEESVGNGIAQSGVPRSSLYLTTKLDKLAAGQTVRDALIASLARLKTDYVDLFLIHVPIVHEDIQATWTQMERCRLEGLTRSIGVSNFQTKHLEEILRVAVIPPAVNQIEFHPYVFKANKPLVKYMMDHNVVAASFGGLTPIARVKGGPLDSVLGRIAKRLSENRTATVTEGQVLQIWLRKKGIPCITTTSNANRMLEYLDVGRVPDITEEEEQEIDDVGSTVHHRFVTGPIGELKFYMANDRLSNALDTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM52</accession>
    <name>A0A2R6RM52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000220">
        <property type="protein sequence ID" value="PSS31107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM52"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="13972" checksum="CC1FCE130BAF7A93" modified="2018-06-20" version="1">MVHGLNLPSTPNDAITHIWTVTLDFVLHGRHTDFVTAYDWTEFDRNLFRLAQSYQLRKFCLGFRSQEDLDRFVEIGVPRMPHLSIIREVVFAIWNSKESKWKRELPQADVNLGIVCSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVF0</accession>
    <name>A0A2R6RVF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000165">
        <property type="protein sequence ID" value="PSS33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVF0"/>
    <dbReference type="STRING" id="98765.A0A2R6RVF0"/>
    <dbReference type="OrthoDB" id="2658589at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="767" mass="85422" checksum="A786F4B09CC26689" modified="2018-06-20" version="1" fragment="single">PHFTQFDDNGRLPPVVAHSVQLDDNGRLPPVVAHSVQLDDNGRLPPVVAHSVQLDDNGRLPPVVAHSVQLDDNGRLPPVVAHSVQLDDNGRLPPVVVRSVQLNNNRGHLLILQSQGYLVLSDPTTGGHFIPSENSAGSQHRNHPSPIHPSLREYLVPDRTRMSSNLAQPLSVFNVEVPTVNGPKIKGILTSPNSTTLPRWEIPPLGPYGENDTAWAGLKTQWAFDGFYYLAFAPLERDYSGPVFGCLSSDGGEVVEDRCNGRTMYRLDPTKCQQWLYLESQLRHILGVLARSTAVLFPLYDRNPQSPSFENYHTPRPTRAKMKNAIGFARARFTQWLAKISYTICISTSEDDEGQELPYWATRILEQQEMEPQMVNALLDSWVCDWNAPRVGAYIDIGRGAVCSESEYWSTSWYDQIPKVLSKVSCVPMWFFYGEPPCLRSALPWYPAAVNSQQSTPATIIPQQPISTGDWGNYAGDCGDLAPGWQSLGGNNGNNSLQGQPKRGETVFSFLDRQKEVKKAVIAQETCTDRTRRLERERQQESQTVPIKSGPKVWMWKEKADSKWVREFVSVKKLASVWRSTVPSQRVYNSIRHEYDICVELDPDASPTDSDIEDDLDTEDDVDMDTGGGGTSAWSPPLTLSPWSLPPTLTLMLSPWSPTLTLSPWSLPPTLTLMLSPWSPPLTLSPWSLPPTLTLMLSPWSPPLTLSPRSPPLTLSPRSPPLTLTPWSLPPTLTLMLSPWSPPLTLTPWSLPPTLTLMLSTFTRSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVI6</accession>
    <name>A0A2R6RVI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVI6"/>
    <dbReference type="STRING" id="98765.A0A2R6RVI6"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="105"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="20672" checksum="F5954CC4A3E5961E" modified="2018-06-20" version="1">MSALLTQPFVQVDAESLPDISESFDVEAVPTFIVLQGHTLLGRISGADASALTDTITKHIRAPSSVTPQSHTEKAPAAPTVVDQGPESDEELNKRLHALMQKDKVMLFMKGNPEQPRCGFSRRIVALLQDQGVQFSTFDILEDESVRSGLKVVNNWPTFPQLIVNGEFVGGLDIVQEMVENGEFKEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZV5</accession>
    <name>A0A2R6RZV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v1476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000116">
        <property type="protein sequence ID" value="PSS35565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZV5"/>
    <dbReference type="STRING" id="98765.A0A2R6RZV5"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="244"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS35565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="481" mass="51750" checksum="FE72848563644701" modified="2018-06-20" version="1">MEDAGTNDELQPRGDGSSIASFTWYIWVMDHDDGGGGDDDNDSTLTPTPTSTTPLASNSTSATPTTSSNSSSNPIIGMHGDVVCTDLLCVGALVNGTTVQYTLQSLDAASLGWMAMGFGSQMANTPMVIMWPNTDGTVTLSQRKAPAEVMPTVDSNPPRIATLESSLSDLSGSNPKLVFSIPANSDTTQDIIWAFSSTNPDDSAADATLIQHLNSGPTQLDLTNVLTASSMDPTNPVLTLASGPNSNSGGGSTSPVTTAVTFKLPPLLPYEKYIVAHAILCVIGFLGLLPLGAIVARWIRTFNPVWFRLHWIIQFGLALPVIVAGVACGITAVHMGGMFHLNDTHMKWGVAIFVLYFFQITLGAFIHFWKPKRFAAKNMRPPQNYFHAIIGILIIGVAFYQVRTGFRQEWLIATGRLGVGNGANIIWIIWLVLIPAIYFSGMILLRRQYRQEREGRKVGLASAPTDGDGAVDLRTRTAAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3L9</accession>
    <name>A0A2R6S3L9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3L9"/>
    <dbReference type="OrthoDB" id="2752979at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="23928" checksum="58457FF70A78AD23" modified="2018-06-20" version="1">MRRLAKDTDLLDFNVGIAQQEPKKWRLFCKKVCEEHPELERYEDLWPVRRYIGTYLLKCRNAERLKIRRLELDDSGDEFSLEDVGEYIAAEQARSSTPSEGSIYCSPKSMAKQSRPLTQAQAASRSRATSSPVNPPSRAEGQSFQMFLESLEPSGLGHLHDAFVDVGINDADAFNALAKFPVAERNNFLKSDMHLNAFQARQVGAVFQALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S482</accession>
    <name>A0A2R6S482_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S482"/>
    <dbReference type="STRING" id="98765.A0A2R6S482"/>
    <dbReference type="OrthoDB" id="3265210at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="600" mass="71022" checksum="CEC9129773110700" modified="2018-06-20" version="1">MALATLQGAPIPGLAAPSLTLSLSHSPTLEEPVPEKPILPQFAKTATGKYRVQTADAQQAFTWFRHAGPLVTVRVNVDVGYSHCTCVLEFWEGSHAITAAKAVKDISESIHEQFTLQTFDPFNLYCAATETANDTTEREAKLRQEEQQRQEEQQRREERQKQEEQKRQEAQRRQEEQQRYEEQKRREAQRRQEAQQRQGERADRLKEIKLRRELTEQAEKLAQKKKEDAVQEEADKINHFLGALQAGRRADQKFRTTKAELYEAQKRFEQAQECFMLAQEDVERILKATDKARVEQREAKTRKEDAEREEKILREERKKVEDEERRLQKEFDEHVVEEDEESRRRAELAESIRKMEELRRQEDEDRARARREAELAETRRRMAEVDAEERSRKAREALAKELKDTARKIVEREAAARRAAEERKKKAREEERELRERAEAEKRAALERKRLYECASAQERVRCMQRDETRWARHISWGVQFCITRFKLISTEFDEIKFNDTQPLTFESIPWPVLHSPYKVTLEDIDWQAVEMFFERLEAVVPVSEYRMLVEKTHRRFHPDKWKSRGLLRTVLDEGLRAQLERTGNVVAQAMSPIWEKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4B0</accession>
    <name>A0A2R6S4B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4B0"/>
    <dbReference type="STRING" id="98765.A0A2R6S4B0"/>
    <dbReference type="OrthoDB" id="21648at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="771" mass="83451" checksum="81755FCF51CE43E0" modified="2018-06-20" version="1">MARATRSSTTHEKEKPLDPTPTARKGGSKKRKRNSIADQSEQPAAKQVRTEDGIKEEPSVEPEEHQEVEHIQPELPSSGDVPIQPGDAIKILEVLEMVDTQGLLDRVFPLPTEHSLSSESEAGPSTGTQSYSFRALLKAPGMFPLRVLRSAVQHLFPISSHPRSRPSAPAAEQLRFCNLALSLLEAASFDSSPVPLYAESLIPTRTDLDIQTDGEDAKPHIPRRQSPVSNRKYALVQRLPTGDWWSSINSSYPTFSVDGKDLKQLPTAYADLVAIFPSSSTPAVSGEPITLGAYAKKPLVKPMSDLTQPRRVTCGKFLDYGQFTSFAPTFEQDGVEIGRMKLGEAIWYQEIDKRRQRRRRAELESVATGSTEISMEDTSREEEDEVVEVEVETRSSKQKEKMKDVDMDIALEGLLPPEQIEALKGALNTLELESAVNELLERNAQALVRLEELQLLRIGDERHGVQPVKIDSEEWDIAQGILDSLTLLASVRPRLPTDVDTAPLIPTTSALRKLHRTLPLESTGGWYGTLPPGQTSAMRDDTTIHVRSGAIVAAPAAMAVPAPASATPAPVAPPTKNAPSTYSNYPYAGYATPGHFRGGYGTYTPTQTSSYYQNYHPPNATAQTPGASHYPNQYGTTGQQPYSYSSWYNYPAANSTQAAAGAVATSGRGTPQPTPAATASVPNNYATFFANAQQPQPQRAVANTVLSAAPGKYQSGAWTNGTVPAYISPTLPPHLRSAVGNGSTPATPPATGTSPYPGYYTSYQGAQPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4E2</accession>
    <name>A0A2R6S4E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4E2"/>
    <dbReference type="STRING" id="98765.A0A2R6S4E2"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5044" checksum="8E07DA944D68129D" modified="2018-06-20" version="1">MTYSMVRLGSYERMKGWLRSNGHASTGTLLLSSMVAGGLGGIAGNPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4M4</accession>
    <name>A0A2R6S4M4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-lysine(36) N-trimethyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v882</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4M4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4M4"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="13">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="300"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS37244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="644" mass="73031" checksum="E20F77566F5DC26C" modified="2018-06-20" version="1">MSPGRLDTFIYEYVGDVVSQPSFLKRMRQYAEEGIRHFYFMMLQKDEFIDATKRGGIGRFANHSCKPNCYVAKWTIGNKVRMGIFAHRNIQKYEELTFNYNVDRYGHDAQPCYCGEAKCVGFIGGKTQTDLAAMDDLYLDALGITDEVEQLGLKGNKKKRSKKLDEDFIPDLKPLLLKDVPKVVQAMRQTQSRKVLVKLLTRIKLTEDQSALRQIMRLRGFSVMTNILEDYAKDIETCVLALECMMTWPLIQRNKVEDSKVNVPVKVCSESDNQVLAELAKKLLEQWETLEFAYRIPKRQKTDGNEDDPQDTSPVEVVEEEDWRPSKRSKRSGTPEDAFTWAPAPMSSERLAELDRIAEQTRASEALMRKAREDKEARERDSFKKQKDDIAAIIAAATAASEAAALAPAVPPPSGDHRSNGSHKKRSSKSKKLSAEEKEANKEKRLLKLVGAVVVKVMSKYQKEMDSDSFKRHAKELTQVIAEKEKKTSSYKESRLDALSDEKVAKIKKFAKEYIAKILRKLDKAGQRHKSSSSAPSSSMSASTSTAHMSSNGHSHANDLHDVDIPTAMDSMDLDDRWDDGWGEPSPMGESHRSSPTTPKHVVDPRVRHRKEESGWDPSYDSKDTFTGVQPYEEDAFDDDLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4R6</accession>
    <name>A0A2R6S4R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4R6"/>
    <dbReference type="STRING" id="98765.A0A2R6S4R6"/>
    <dbReference type="OrthoDB" id="3183258at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="239" mass="26738" checksum="A84BA880E72971E3" modified="2018-06-20" version="1">MKVMVGALFAADTLNCIFDMWWIYDILINHFSTSDVLLCEKITYLTHVVDLNALSTGNWSKSCLTLMIKYVELIPYLQSSQRGIIATMVQLFFAWRVKVLTGNMWMVTLITLTAFGHLAFNFPLAKLYTNSLMSSLNSRTGWKYQTSGESTGHKISRDPQARRMDVVNLSTATRPEVTHSLLGPEVSPARSNLSLPPQVFVHVESHELADVGDKRDIEWSSDAASASDASKRQEFGSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4W8</accession>
    <name>A0A2R6S4W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000067">
        <property type="protein sequence ID" value="PSS37295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4W8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="296" mass="33428" checksum="180D97B2D1732158" modified="2018-06-20" version="1">MSSEDDIITLEKLAQKSPNLQTLSVNIYLTPVESKSMEFRFRNLQNVTFRVRLGCLPLVSSYLHMLVQTTSLRSLHLYYPGLSIIWDIQNVDNSVLKGLIEALSSFRYLQELAISISPFHAEVVNPDSAHLDPLMHLTRLESVSFTGVDFGLTDAVIQRLISVWGNLKKFRFVHYSDRTSQVSLAVLRSFAAYTPKLEDLRVNLDATCVPPRDHGSVTASVLPVHIDFGCSPIQMFGSSRQVAKYIADIYPHAILQFHPDNPCYLKGCKCDYRDMWKQVGETIATFSGNPLPKFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4X3</accession>
    <name>A0A2R6S4X3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4X3"/>
    <dbReference type="STRING" id="98765.A0A2R6S4X3"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="203" mass="21869" checksum="D3EAF03802B98B4C" modified="2018-06-20" version="1">MPGRRTLFRPCIDLHDGKVKQIVGGTLSDDTDALKTNFVANHPPRYYAELYRDNNLEGGHVIMLGKGNTDAAREALAAWPGTLLAISWVLGCLNSFALTSKFVGRLQVGGGITDENCAEWIAAGASKVIVTSHLFPDAKFSLEKLARISDIVGKDKLVVDVSEFLVHAADVEGLCKGIDEQLVRNLGTWVTIPTTYAGGAKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S521</accession>
    <name>A0A2R6S521_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000045">
        <property type="protein sequence ID" value="PSS37390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S521"/>
    <dbReference type="STRING" id="98765.A0A2R6S521"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="27570" checksum="EBC5FE1E02C1EE3F" modified="2018-06-20" version="1">MSVGWSTLTTTKASGLGRSLAHQYSERGGKVCVVGRRRDELEKVLAECLALRPGPENDGVLIHAGDFTNVDDMVRVRAFLQTTWGGLDTLAVCAGVSALRPLLEVAGLERHATSEASPEGIHRVVEVSNAAFKGNFTGPLVSAVTFVSHRLNCLITASKGEDGRYLFLNPPRRHLPFYSFRVWRRLFPLQHGPFTVRQSLLRWFSTSLLPSNIQRLLSLSRYLLPLRATSEHPPLMAENPGKQTQTKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S552</accession>
    <name>A0A2R6S552_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S552"/>
    <dbReference type="STRING" id="98765.A0A2R6S552"/>
    <dbReference type="OrthoDB" id="5576441at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="602" mass="66849" checksum="3F32C2B0EC0D8BA9" modified="2018-06-20" version="1" fragment="single">MTTRPVTHFARICLGISLLSHASDRFMLSSLLFTRNILPRKLNRINTFVSARLIQRPAHMFNTSRQHFGQRIPHEDDVVEDSEPEREERRKAEKERRRARRQLRAAASQCAGDIIDTIGSNEPKHVQSHSIIEISDDSIQLSPRPAKQDIVKNSVTYFARAVHRRPSVYELSSDNDVEYPAPFRTLNYSSDTTFPSVREILGLPKTKPSQAISQNPSQDSADPPPPTNTTARTISGGQDSAPANPEGSDDDKPRPSNLARFAYVAPPRSSSFQSLHTIRSARSVEPNNSSEVPPPKPRKLPKATSHRFTQFSDADLARLLKCVSCDLTWTARKTVVQKMKHVQTCAKKTRLTDDTIAILIRSELAKTPRVASHNSKGKEKATEPEQVEPQTLLEQVINDGGAKKRTKRPQVVETVKDPAQTRQNILDRARLLLSSHFSTHKATVTVDSNPQVRGLPDALYQSPPRTQPFGESALAQKFRSSALADPTPTPIYVPSPAPIASSSRAEPEVHPVLANPSNPPRTQPFGESVLAKGLQPHTHKQPLPSPRHDSPVFDNMFLELDENEDIPAADPRLQTRDDLNSVSPLRSYSGQIILIEAVVQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S565</accession>
    <name>A0A2R6S565_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S565"/>
    <dbReference type="STRING" id="98765.A0A2R6S565"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="226"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS37424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="505" mass="56241" checksum="5D61538569FC31B6" modified="2018-06-20" version="1">MDPQKLPAYPPLSTVEQLILKEKRGNCVPIYVELPGDLLTPCTAYLRIAKDSKYSFLLESVVNGENIGRYSFVGADPFKVIKTGPHEEIKGDPTAVLQKELAVHRYVKIPEVPTFTGGAIGYVAYDCIQHFEPKTARATKDTLGVPEAVFMLVDTLLIYDHLFQTVKVVSHVFCPDNIAASNLSFMYQTAVSKARRLAKLVLSPTTPEVVQPPIVLGAEALSNVGKEGYEGFVTALKEHIVAGDIIQAVPSQRLARPTSLHPFNAYRHLRRVNPSPYMFYLDCGDLQIVGASPETLCKVEQNKVYNHAIAGTIRRGKTPEEDERLGAELLNSEKDRAEHIMLVDLARNDVNRVCQPKTVKVDHLMRLERFSHVIHLTSQVSGLLRQDKTRFDAFRSIFPAGTVSGAPKIKAIELVYELEQDRRGVYAGAVGRFDFAEDEMDTCIAIRTMTFKDGTAYLQAGGGIVFDSVEEDEYIETINKLRGNVRALEQAEQYWYDIQHAAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5F6</accession>
    <name>A0A2R6S5F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000040">
        <property type="protein sequence ID" value="PSS37521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5F6"/>
    <dbReference type="STRING" id="98765.A0A2R6S5F6"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="175" mass="18380" checksum="E833A3176F4DAA42" modified="2018-06-20" version="1">MGFTHDNNIPPVIAALGLLNSSQEPGVFPLSPTTPDPRRTFRASHLVNFLGHIALERLSCEAPLAQSVQHIIGQLAPVPGNGVHARKFVRIRVNNAPVPIPSCTSGPGASCPLADFSHHVNGQLAARAGDFVERCGLTSVVGAPDVVDFYVDPESKLANTTQLLLVIDVPGGPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6C3</accession>
    <name>A0A2R6S6C3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6C3"/>
    <dbReference type="STRING" id="98765.A0A2R6S6C3"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="111"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="385" mass="42599" checksum="DF8FD179A1909D65" modified="2018-06-20" version="1">MSTSTAPPIARAGSSAEVQAAAFADDPRIHFDRTAGTWRLEDDDGNEMEYDAAKGAWVSLTPAAPVLARTKKRKEPEDYTSNTLGVEPEPSTKRGKKAGNGNKPERKSKNTAVYVTGLPVDTEPDEIVERFSKFGLIEEDDQGEPKVKMYAKEDGSFSGEALVVYFKEESVMLALNILDDAELRLGDASTRMSVKKAEFGNRHEAGSVEGSGEVKVRKTVDKKKATRRIGKMQKKLGEWDDEDGFGPSITEEDKTRAANRIGRVVVLKHMFTLQELEEDASLLLDLKDDVREECSTLGEVTNVVLYDKEPEGVMSVKFRDPLGAQACIIKMNGRFFAGRKIEASLYAGKQRFRRSGAGEEHEDEGDEAEGRRLDDFASWLMTEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6M1</accession>
    <name>A0A2R6S6M1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000018">
        <property type="protein sequence ID" value="PSS37916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6M1"/>
    <dbReference type="STRING" id="98765.A0A2R6S6M1"/>
    <dbReference type="OrthoDB" id="2418900at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="937" mass="105667" checksum="4125A5AD01AC8817" modified="2018-06-20" version="1">MALQPLAGTQPAGHSNAHLLGLAPYDNESGDSQPLAYMEPQPSPCFASAAAAALDHDDPDAILPTAITTPPASTKVDPPGTRYIDSFPSQSFAGRAYSTGRTAFDETADKETSQSGHLWESFANEDDWKLAQWLVKNVGHNQAEEFLKLNTIKTNVAPSFSNKDKLYAAVDALPGGVAWKRKEVSQTGDLTSSDGKPLVEVMEVWYRDPVECVRELIGNPLFKNVMAYAPEKVYEDMGGDVRVTDETWTADWWWKLQESLPKGSTIAPIILSSDKTQLSQFRGDKSAWPVYLTIANISKATRRQPTKHATVLLGYLPVGKLAAFSDKARPLAKYQMFHSCMAVILDELVNAGREGVMMTCADRRIRRIWPILAAYVADYPEQCLVAACMENRCPTGNVIPESRGEYEECTHRDLQETLSLLQAHKDGTLTETQKDRFKTLGLRAIHEPFWKHLPHSNIFHCFTPDLLHQLHKGVFKDHLVKWCTNLVGEKELDSRFMSTPSLQGLRHFKTGISKVSQWTGHEHKEMERVFLCLVAGAVDERVVQAVRALMDFITLASLHSHTSQTLSLLRNSLRKFHSLKNVFIELEARLPPHFNIPKYHMMLHYVDLIEQLGTADGFNTEWSERLHIDYAKDAYRASNKKDYIAQMTKWLSRQETVDRFAIYLEWRRNGEYLPLDLEPLTANRTLMASTRDNLNVASTASTITPSTRILCRPPVRPELYHVAASHPQSLRGIPAAEIITHHNALRFLPALSSFLHAHGSLIIPQPVHRFNLYKDLTVLLPGIPQTSMKPLKNIIRASPAVPAAGRKAAEPSHFDFALVRTGETNAVTDCTPLQGIRVAHVRAIFKLPEHYRIDTLHPLVYLEWFTPFHAVDHATGLFTVSRSTRMHQVYGEVVEADRLVRNCHLAPKYPRTKDPSWTKRQMSTYNQLIFMYILSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6R8</accession>
    <name>A0A2R6S6R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6R8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10561" checksum="14E9C0B4F7C1B688" modified="2018-06-20" version="1">MEMGMRRVARRLLLAKVGTRWAAEKTFKVQGSDGACPSPPAESWTEEDGAGAGATEADSHCKPGQVYTCERRPILGHGREYSAEKKRVSYAGSGDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6W6</accession>
    <name>A0A2R6S6W6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6W6"/>
    <dbReference type="STRING" id="98765.A0A2R6S6W6"/>
    <dbReference type="OrthoDB" id="5280534at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9423" checksum="9FC95ABEAD08CA1F" modified="2018-06-20" version="1">MSGGVEIHSVPKVSAPAQSNGKLNKFSGQLTQNKMRGGAQAMLYAVGLTEEDMNKPQIGISPIWWEVTLSRWVPTAQHYDANISIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDJ6</accession>
    <name>A0A2R6NDJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDJ6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="109" mass="11619" checksum="82326008DAEB212D" modified="2018-06-20" version="1">MDAEMDDKEETGTEDATEVATLKTVLELSSETEVNALLATEVRRLELTTEGSALELAAEGRTLELATEGRRLEEALAVGTGKRVDGITVLSEAIELEGTAETEHAASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE13</accession>
    <name>A0A2R6NE13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001344">
        <property type="protein sequence ID" value="PSR70617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE13"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="312" mass="34813" checksum="5B17B30CBD69C540" modified="2018-06-20" version="1">MAIGPATSSSTAPAVAIATAPKSNVQVVKKPQDTSSMDVSVSISSQTKVEATQHTSKAPKPPKTEAPKKKSVSTVDIPLPNVPHAKDIWNASGGIMHTWVHFVSTLENPWDANLTGEEMKTLCKLWAIGFPKNEERISSGTKIHKVSQQRSYDWRSRAGKKGIFHVLEFFKQQGLDTEEQRKECATKYGLSYLCMYHDDKTWQERSAAIDEAKANKNKDLTEQLELEHAKISKFSEVWNIPTTSFIQGINKLSKRAWKRTVRDAQKFVTQSKSSSKVHTEVEQVPDARAMIVNEESEEDSEDSGYTGNSECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEE9</accession>
    <name>A0A2R6NEE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001337">
        <property type="protein sequence ID" value="PSR70659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEE9"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="413" mass="46471" checksum="92021B6E9149D526" modified="2018-06-20" version="1">MSTDAKDPCTASGTNAKPVQRKLIGMRWPCRYRRSSLLNVDKKTKVSVYSRDGTKHTLFAIKDDSQVITQFVVPIWDVPKKDKTRPNGRLQAMLSTATGKGRCHLLCLPAEMISMIFGEFEDVKDAVCLCLVDEWLSSVGMKSVRKLVARLAAPWSGDRVIHLGFHAADDDYPESVQEHVTAEVAAFKAKYGAAQLREGGASDSDESSSSDSDFEEPKKRKNPPRTIFPHVYMRYKSNYSIPRGVPDVEPYRVTRGCWTGYASIYEVLSPKDASRMKVMLRTSYTTSQGWALCNLSKKEYVRADEIAKMTKSTCRGPWIKHTVNLGMVLLLRTTWSSAELVEIKDPKGDMHRGVWAGDRFEITTLDRLKGGQKGWKDVSMAVVAEVDALCELNYGTKDWVTEIQEDKKKSYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEL2</accession>
    <name>A0A2R6NEL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001312">
        <property type="protein sequence ID" value="PSR70813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEL2"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="82" mass="9797" checksum="139E50E948EFBA48" modified="2018-06-20" version="1">MAEAYEKPSQKKSSSTEKKERKKLALLELRVDLNHIMHHPKQKRYISLFPPEVRFKSRQPRKRTLCGRKSGKLPEAIWRVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFR6</accession>
    <name>A0A2R6NFR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFR6"/>
    <dbReference type="STRING" id="98765.A0A2R6NFR6"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="42573" checksum="8D1E3C08BA18B0D2" modified="2018-06-20" version="1">MHELLDHFEEYHVVVLGGDGRPVYPPPVHAPSYPSGSLANPAGWASLAVDYPQPYPPADASFQTYAPPDASGPLPATPSVGSSFQSYPPTAFTLPPHMRVPSPAPRFQTPYQVQNPASDVLDPHRMDVDVDNQADFHSRGSSPSSAISCPSMTWSDSPSSPSQASSIRSSPNPGQSMCLPPTLLTIHPFQASNEAEESALHPDPRLPMSPAGTPSVSDDEEGREKDKKTITGRIKAKLFNSDSDSAERKSVQGLRKRDSRREKAYKCPHPGCIKSYLNPNGLKYHLEKGTCIIDPSYRIPSPGGTDDHIPNSQPGPSVANASPSPDASRSQPGPEIVSRPTESALPTPIPLMMYPQARDPRMESVVSGPSSAIPTYPHGPQSPGTLYAYSYPLQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFV9</accession>
    <name>A0A2R6NFV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mon2/Sec7/BIG1-like HUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFV9"/>
    <dbReference type="STRING" id="98765.A0A2R6NFV9"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="2">
        <location>
            <begin position="228"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="47006" checksum="6FE7EEC5259E3446" modified="2018-06-20" version="1">MRGFQDLRRLAKDVEDIRSLPLPTLLGPFFAIIRSPLSTGPITSAALSALHSFFQCDLISPGAISLDACLSEMSNTVSRCKFEASDSSGDEVTLLKIMTVIQDCMCGSVSTTLGDIEVCEMLETVLTTCCQMRLSEILRRSAEATMHALVKTAFTRLYVLDPIEEEEKLSDNGTVGQEGEAKMTVSTELTGGSESRVTETGVQGVVSPQQVLAPSENSSKPSYGLPSVLELLRVLINILDPTDQAHTDSTRLTALRILNVAFEVAGERICDFPSLSALVLDHGCKYLFQLARSDNPAVLQTTLRTISTMFETMRRNLKLQQELFLAFTIDRLAPPPPPPNKAHSLKTNISPRPGTPTSGISPADVDSDKAPSTPRLLVAPARGDTRELLLETLSLISRHPSFMVDLYTNYDCDMNCENMFERLIDFAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGQ5</accession>
    <name>A0A2R6NGQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001269">
        <property type="protein sequence ID" value="PSR71567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGQ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="174" mass="18374" checksum="84C9965118DEB77E" modified="2018-06-20" version="1">MSTSAPANSYGTRKGNADKHVPSELLPKKRRSPAEVKAAKAAAAAKAAEANTKQLQILDTIARLQAELDSERTKTAKILPPDPANLVPHNTVAKTYSKKKATGAAKSSADPAPPPAVVAVKPTHRNIPEKITRAKIDMLAQHLKIAPQSKSPITPQAPGRGKENVPPGVPMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH79</accession>
    <name>A0A2R6NH79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH79"/>
    <dbReference type="OrthoDB" id="2803722at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="444" mass="49366" checksum="1ACDDAC46B5FC6E6" modified="2018-06-20" version="1">MFANTDKYYHRTLSPLLLDRTYHLQEYFPENTVKQHTPEWLCEPPLSFDDVLRPPSYLIASLHHALNDFSWDHDQQPPAYEQTIGASSSSGGEFTPRPPSPERRSIWEDWDSDGEADPESGSEGANDADDERDAQGSVDDAGLDNREDSEDVFSELDLEESDDSDCETLLDTPLPGLTPAFGIRNQRCEVEQQENSRPPYIPPPAYHLLHLHHLLENDSQSKVDPYSDLASCLSALDPQLLLTPFTAFGEACYHAAIRGDSSPPTLRPFSRAVSPQPTASTSSASSSSLVTPRHAEPHAFESQEKCPPLAERGDESDGEDEILRSPIQAFVSPPLVWDGRGEENRRNTNELVISDFARCLSPVSMSLLLSQDDPPGNENIYRKMRIAPHTASTDVASLFLHTPVPVRTQDSVQCFPTRPTPPRDRTVVGSVRGLLLRSLNFNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH93</accession>
    <name>A0A2R6NH93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001244">
        <property type="protein sequence ID" value="PSR71755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH93"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="64"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="874" mass="97785" checksum="655515B603376818" modified="2018-06-20" version="1">MGLSMDMGPTTADQSQGAVVVTATTSTSFECRQQGQSISAGASEKPTCGCCSHSKGPTEKPDGWKVLLGAMEQSDQKTLDRWKAEMDNLLIFAGLLSAVVTAFTVESYQWLRDDPAATSVVLLAQISDKMTSFSVAAGFINSTEPNPRPIDTSSFSVPDAVRINMLWVLSLTFSLIAAFLALAVQQWLRHIPLPEDMTIRQSTRLRQFRQEGLGHWRVPMIVSFLPILVQVAVILFLIGLLYLLRPLNHDIGLAFTVVAGSLLGSFAITAFLPFYYRDCPYKSSFFPTILCIVQPIAKTILYLGLFVIYIVATVSVFGICLALGFAIIDIGLAVCLVGLALFPVVFTFSVVIPALYNCTSRCLRTVSSPIARCLHPILHRVKEVFRVSPIVSFIHDALSSLSTFIHKGLSGLKALLHRVLPFGRSKGDNQSLWSIALRLWERFEEARKNKQEMVNNKFGDPEKLWLNLELKKMMSDSDIWNSLDESVLASAPMAVARSESSFNTVKECLKDLELASHRALCAFKWAAHHLGVVSGSISDEMCDYSRFSGINPRLLRKVDKIFAERYRETLWEVLPMDGHEFFDEGRRYILLGIMILLMETTKFRHDEPDYPKFVQGYMDLLMKILQAQIGRSLTSDNVRHYGRLPTALIYEGCIRHKHNFRDGDVEHAVNWAHQQLTAGYEECTLSILELTLGSSAIALIAIAQSQDERFVVHSCQQLVPALKTYLESNKQKIQYKAKECALRDGLQVRLVFQHAMSSIYDSLSTLSQSHLYTDTRKKDPQNDVDLDGDAEAIRSTLKEMLQEQQFFNDVLWEVEFPEGVPVPRQRTATPPTTTLEKKPDEAPDAGSEEKLPSADEDDPDSKKADDFGIATLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHA0</accession>
    <name>A0A2R6NHA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TMS membrane protein/tumor differentially expressed protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001286">
        <property type="protein sequence ID" value="PSR71372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHA0"/>
    <dbReference type="STRING" id="98765.A0A2R6NHA0"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43911" checksum="2AC63F17A6C0DD79" modified="2018-06-20" version="1">MFAWLMKTPVAIKQIEKWSHGYLEMDCAGGKCYGVLAVHRICFALSLFHFILGATLIGVKDTRDKRAAVQNGWWGPKVLLWLVLVGVSFFIPNGFFMFWGNYVALMGATIFILLGLVLLVDFAHSWSETCLENWENSSSNLWQWILIGSTAGMYAGTIALTGILYGFFGNSGCSLNQFFISLNLALCILITVMCVHPTVQEYNPRSGLAQSSMVAVYCTYLIMSAIGNRQHDTCNPLQKYRGTVQGTHTTTVVLGAIFTFLAIAYSTSRAATQSRALVGKKKGTIELPADHGIHGHAELGVVNSQPGRTETPRYQALLAAVEAGAIPASALEEEQDEDEDEGPVGEHRDDERSGTRYNYSWFHIIFAIGAMYVAMLLTDWYVTTSISRLTADLIHFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHJ1</accession>
    <name>A0A2R6NHJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001241">
        <property type="protein sequence ID" value="PSR71855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHJ1"/>
    <dbReference type="OrthoDB" id="2803003at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="380"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="607" mass="67750" checksum="4458305F77819872" modified="2018-06-20" version="1">MPSTRASNANTHPGEVVLKGQRTRRSAAEMKAVREAEVLEKAEKEKAERTREEIIKAIAKLEAEEAQKRRTKVPPSLQGLVVKGKSGVQQGGSSKDKGNGGSTKSPKTPLKRATTSGEDSSPSVKKARTTAAKLTRANVELIRSSENEESPTLQSRGGKGKQMKLSSQVLVPVKTQQTALGTKAASSSSKGPAKAIGGFLQGYDPSKAKAAQKTKISVAKKKVLDDPIEDIEMEDFDEEGDEERLSDSDASDKEEEEEERSIIVIGSSDTEGTDGGDEVNNRDRYFISERQSSEVGSPLGVEGDVKPMLRRPTAGKRKWTRFDLPFRVEDHKQYRDDFIRWVVRVMGEHPVTFNQNSVKMESLMQAEWGKTFPDMYFEFERHTPLFDITQQKIWDWRSDIGSLAYDHVGEEFKTTLKDLTEEERAEYVTALLKKGNQLPFIYARTEKMPDGTTELIGAFQGPLILKGLAAHLKQVSLPGEKLLDTVKPVGALALIATAVERAFTASKSGSVNYKHSWFSEYNWGDTSMRYLKAVRQLDDPTWKRIIQRAKQYLPQVGKPSEFATLNTLPEEEVDNYTIVEKRDELWKDPGSDNDEENVEAENMQVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHX3</accession>
    <name>A0A2R6NHX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHX3"/>
    <dbReference type="STRING" id="98765.A0A2R6NHX3"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="32941" checksum="BF1F1569C5B54A34" modified="2018-06-20" version="1">MDDGKPSQLLSSAALCEHETEGDDDEDDVNMDSMDQPRFEDSDDEDDDIDDDEHELTWVEIGPGDGQLTSNAKNSSMGPRVQPRNPTSNTEEEESPTSAQTAESWASVPGSLEDSLMAVAGGRALHDNDEGLGDAPRNVRQKVVHPSTPRSRTRDIPDAEETRETGRNPSAKRDNRGPQKIRVVVKDAAYATYRAVLYYIYTDTIVFAPLASSFSCHAPTPELNKHISPSTVTAAVSTPAATSPETQANYILGARSLQQSNGKGKGTGGSPTSRREWIEEGLKNNPGRPRPCSAKAVYRLADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI31</accession>
    <name>A0A2R6NI31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001228">
        <property type="protein sequence ID" value="PSR72019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI31"/>
    <dbReference type="OrthoDB" id="2744824at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32363" checksum="AF12C153D3BCE0B3" modified="2018-06-20" version="1" fragment="single">MVSNDTQLSRTVGPFPQTFSAGLICEILGYVRDSKSTLCACSLASRLWFGISRPYLFHSVTIDCEYVRRHFDDTENLTRDFRGRIRPFHAFLALLQGTPSICSSIQELCLKGSLFDFPEETLDRYLLCGILPLLTQLRLLRLENLELWREPGTYPLIGLTEESLMEFLCVIPSTVRTLHFESLDKVHGIRDGSSPSGPGGEIRLPTQLQIDTLHIISTSEPGITWLCQAFARSYQSLRNVRSVHATLEWISDPNLGEVLHAIGPNLHHLTFNVDYELDGFSKHSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIX3</accession>
    <name>A0A2R6NIX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001196">
        <property type="protein sequence ID" value="PSR72319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIX3"/>
    <dbReference type="STRING" id="98765.A0A2R6NIX3"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="574"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="667" mass="76091" checksum="144C4F0471A7AAC4" modified="2018-06-20" version="1">MECRLTYHPRPWQCQVLLRKDTDEQGNRIAAREEPFGPLLFDESELEDMLRRAQLAILNPSLPSKFFFDFDTSSLKPGEKPNGSAKQLAFSNNVVCMDLQAPDVTDLSFIDLPGIISNVAKGDDRNNIDAVKNMVKDHIRGNTLILLTITMRDDIDNQGAAFLAHEEDEKGLRTIGVLTKPDTIQHGEESGWLKVLEGGSHPLKHGYFVTKQPSPKELEEKISYDIARQRETEFFDNTHPWDSNSDLRKRMGTANLTKELSKLLGNVISQALPGIRKQAKDSYQEVRRLLDSLPPPPSENPAAELLRLVTGFSADVDHLIEGRESYERLIQRCRPAYAQFKRDVRSTAPDMRPYENKFKDPDVLSFSVVDEDEDEDEDEDEDEDEDEDEDGDERKACSGPMYLDGVRAHIQGSLTRQLPYNVPFAAKVSLIETFFADWEMYNLRCFTDVYEATLDELKSLVDVHFGQYYKTALLDNINAIIEEQVERCRNSTIEKMQWLLELENPPFTNNAHYFSSYREKYLARYKEVRKPAPTLLPADIRVQNALAALSAIGYTGIKQDDLPRLHGTDEYDEELMVMAETSAYFHVSYKRIIDNIPRVIDHNFLRSIGKELQSSLITGLSLATDQASEKAAIYLAEDEQVASQRVYLEQKKNRLDGVLKRLFNFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIY9</accession>
    <name>A0A2R6NIY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIY9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIY9"/>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="588" mass="64959" checksum="ACA88B123104005E" modified="2018-06-20" version="1">MHKGDLFQNGKSQGFGKSANASDSSAENWPEQLEKFAADVDHLVNYVDDFSTEFIDEAVSATSLPLVADLKYWASCLKTYKGQFESREIQTYLHELTEELGRHLENIAISLSTFIEVGIPSIRYAQKHGNKTLLHLSTVATFFSAVTATTLQYSFNQTATTLDNLVNGFWFSSLLLSSGAALNTWLVLTWKDAHYRSPRHHLPLWVSIWITQSPPAFLILSSACFLIGLILFVYSSGQAQGTHIAAAAVFACSCLGLCIISVWFAAERWIFSYYKGARRLSDILAKSPGLYHLPIAIASWLFQEIQHGTYKMVEWFVRVGNEVVQDINAAVVGARERRQARVASRADVESRPVSNPRTESSTGIPRLPTIPELGPTRMPGADGSEKYDEDIPAVNSHNIPLRTRLVNKFRSTPSEVPVSSTNSGPTTTRPPRRIGSTSKPMDNLIRSMIVYGKAQRSTEKGAAQPKRKRTGSTEGSRPHSADFSVPTQHGTLTNILKRIETTHVMRTNQGLVSHLQFSPNGKFLATSSWDCTVRILGVGAPYTSLHILAHPKRLVTKVVWSPDGEMLLTLVARGINIWTKVGTICMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIZ1</accession>
    <name>A0A2R6NIZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIZ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NIZ1"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="204" mass="23320" checksum="88FC2523F254A322" modified="2018-06-20" version="1">MDTWDDEKLQKVVLSKGGNPRTTTDIVCKYFIQAIESEKFGWFWECPNGENCQYRHALPPGFMLKSQRKAAEEAEKANTISLEEFLEVERHKLGSNLTPVTPESFAKWKQTRMNKKQAEEEAVKKAKDTQAAAGKNSGMSGRDLFTYNPEWFEDEEDEEDEWDLAKYRQQQEAADQVAEEERIRNLQLDDGEPSPSSSGGDEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJC7</accession>
    <name>A0A2R6NJC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001166">
        <property type="protein sequence ID" value="PSR72495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJC7"/>
    <dbReference type="STRING" id="98765.A0A2R6NJC7"/>
    <dbReference type="OrthoDB" id="3234307at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="579"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="885"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="895"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="925" mass="104057" checksum="03CC6892B527AFF3" modified="2018-06-20" version="1">MPKWRICQNFSQVNKLTEIAPMPQGNIRLKQQNLSGHRWVSTFNFASGFYAVTMAEESRPYTCFYVEGRGYFWYLKMPFGLTGAPSTFAHLTAAHLHDLITDGTMELFVDDGGTRGSDFQTKISNIRRILSRVRERHLFLSAAKLQLFMTTLVFGGASVGPNGVTTNAAKLTAIVDWEKPSNALQLSSFLGVTSHFRDLIRGYSKIEGPLRDILKAATPPKNSGKSAYRRALSSYLLDDTRWGKPQTEAFIALKVTLTSEPVLRCPVWDGTPFIITSDSCKDGFGAVLTQRFQTVLPNGRTVDKLHPIAFASKRTSKSEEKYKPFLLELAALKFALDKFSDVVWGFPIEMETNCSALRYVLTNDKLNDTHSRWRDSVLAHHIVDVRHIPGQTNIADDFSREGEGHPHKPGDGSDWTVQEDWEHRKGLDNDILLVENVSAHTDSDNQLLQQFEQEPLFLEVVKALQDTENSDMDERTRQRAKHRASQYMLEDGRLWKVRGGTKGRPRVRVECLTRREAKELAAMEHATGGHWGRDAVKLALLDRICSPKLDQSIMDAISECGKCKNFGSTHLHLLLDPITQRKPFELIVGDYLSMPMGKGGFTNLGVFLDTFSQHVWVFKHKTAGTSKTTIESLTSISRDFMPPDTFMSDGGKHFDSKEVREWCELWGTKPHIVSAYSPWVNGLVEGTNKILLHVLKRLCAIDLGEDECDTLATEHLPKNWTTHLDAAVYALNNRILPAFHHTPKELLLGISIECRPTPLEQAVSGLLPEDVGVHFLYVDQQRLDGYNAAVHHAIKRKEAFDKRVARSRGGNVMFPRGSLVQIYRNDLDNTHQTIQKLLPKWSEPRRITGCTGNSYHLETLSGSPIAARFHARQLRTFRPRMGTTLAISKLRRPQVHTNPADGTSSPSSRAMAPAGSTRLHSEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJU8</accession>
    <name>A0A2R6NJU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001148">
        <property type="protein sequence ID" value="PSR72644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJU8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="14183" checksum="846CAE74D2C8C333" modified="2018-06-20" version="1">MLQYPRIGPPLLSTYDTLIAMHPAKFSFSSKCSDELVLRMYRHSVSHVAQQVAGLSHLRLRSLKLAPGPFTPMASFVQAILSTPVLNTLDSLSFINFDNKESLVTAGRLLRGVGPQSLDVCIYLSTSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKV9</accession>
    <name>A0A2R6NKV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKV9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="283" mass="31460" checksum="821D06BA2A864858" modified="2018-06-20" version="1">MPTYMKLAPPTKPVAFLNPHYESGVPVGQKWLGPSCFAPGPHNPGPLKFLPDAGCFWPVYEAWCIYSNATIEGKEDLFIEGTNIELPRFEQELMLAIRQSHTRFDLNELDSWRVLAGCLGLRRTPGSLARFIPYASAMVTASSQAVDVLVVTKVPTAFANRINTMWPISNEPNTLCPDVRRASDITKPRYQDPIYQAGFQDGEHWKEGSPFNPTSIPPITPGCEGPSQAITLNRNLYGLLLVELEQEQKLDRVANQLFSASDPWLLSYIASTVTATSMDSCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL39</accession>
    <name>A0A2R6NL39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL39"/>
    <dbReference type="OrthoDB" id="2974599at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="20716" checksum="64BB19C3198B497E" modified="2018-06-20" version="1">MIMLAAADPDSTVRDDSDEGCGYERTQAGVPLMLHPSRPLTHFFTPSSSQSQPHLSRLLVPNGATMLPYSAYSDSRLTPLARAYTHQRVTGVGVDSAGRRFDSQYPASGESEIADVLPAYDDKDGPPRYQEALGEVHISGPSPPMVSDTPIAHAEPRDMISSHSNANANNQRCVAPFSQSMISSDVYPADKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL71</accession>
    <name>A0A2R6NL71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001115">
        <property type="protein sequence ID" value="PSR73076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL71"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6331" checksum="33A84467D3160025" modified="2018-06-20" version="1">MGDNLGRLCQQIADLKIRGIYVYFARLGASLPSLPSLPSLPSLPSLPSLPIGVGRRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM69</accession>
    <name>A0A2R6NM69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v10777</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM69"/>
    <dbReference type="STRING" id="98765.A0A2R6NM69"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="177"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="68"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR73485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="621" mass="67391" checksum="4FFA0B3D98EE8E35" modified="2018-06-20" version="1">MDDEAMDDGEDLSPEDLEQLTQGLEQIRATVGSEAESGMTDKDIKDALYHYYFDIQQSLNWLLEEQARKHAAQERRAAREREKAQKLAMQKKAAEVNARLSSGPTRKKGAGSSDKAAGTPISKPAPDTQQQLDISALNLDTPEGTETPPDEPPPKITIAREKVLEEARKALEGTGDKKGVSLVVIGHVDAGKSTLMGRLLYELGRLDEKKRIANERASSKIGKSSFSWAWEFDGTTEERERGITMDVALQAMETPHRHITILDAPGHKDFIPNMISGASQADCALLVVDAATGEFEAGFDRGGQTREHLLLVRSLGVGQVIVAVNKLDQVKWEQDRYEEICSLLRPFLIHSGFQPSKTTFVPVGAMAGINLAHRDNPEATPLKAWYGGPTLVDLLDKLEPPTRDIIAPLRFPISNVFKGRSSGTAVSGRVCSGLVQVGERLRILPGDESAIVRSIEAEEDSLQWAAAGSNVTLYLTAVDPVHLNIGSVLCPLTDIIPLATSFTARIIVFDIQVPITAGASVELFHHSRDVPASISRLLATLDRASGAIIKKNPRVLTKSASAEVQISLRGSTYSSTSSRVQPIPLEPFGTNKEMGRILIRRGGETVAAGIVLEVTENANTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMQ2</accession>
    <name>A0A2R6NMQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMQ2"/>
    <dbReference type="OrthoDB" id="5597211at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="184" mass="20692" checksum="20CB92839D4A269F" modified="2018-06-20" version="1">MSTIVLRRSIRRVPVLHRHVAASAPKGQQELPAENTLDSSEPKRHTTQPSAKTRALISIYHQAGDFISPDNLSAAIDKAFLDDVETPASLYQGRETSLGTLQQQMLERWKLPKVGTGKEQIIDRKRNPMPGRWSDMKSHRELAVMGALYGTDGSAEPSLEVLEEEAARIQEHLRRDAYEENRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMW6</accession>
    <name>A0A2R6NMW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001067">
        <property type="protein sequence ID" value="PSR73722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMW6"/>
    <dbReference type="STRING" id="98765.A0A2R6NMW6"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="265"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="38457" checksum="7F1F38A66CA3C650" modified="2018-06-20" version="1">MFALRRNSCRAIALVARTQSRNIAVSVLPRLASFPATGVKYANSLTRAVAGRRLFNTEPGQAVRFNIIVFFFKEILKHLTSQEETFVEGRQVFVYDLPREMTTEKLTDAFKVFGNVESIVLRQSEDAPGFAHITFVDSQAATAALQSVLFDGQHRPAVQPSSTDTIRQARTPDTLFVGNLAGEVQADELKNLFSPYGKHTIRRSHRRSAHIQFEDPSEAERAARELKGTEIRGLSVRIDFARPYRQELAQARWTSRPRELSPPSETLWIGNIPTDISVKALMELFGPEGAIECRHNAFKPYAHIQFPDTQTAQNALEKLNGTKLNDATIRFDYAARHSDRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN10</accession>
    <name>A0A2R6NN10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN10"/>
    <dbReference type="STRING" id="98765.A0A2R6NN10"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="21860" checksum="2F85527F7C463E3D" modified="2018-06-20" version="1">MTDVETTTPTHNSSETPIDDVEEEESKVGGEILLMKQRVEEMEREASKLRELQAAAEKNEIGDGAAGDASVPMETEEERAAADGRSVFVGNVDYASTPEEIQQHFQACGIINRVTILCDKFTGHPKGFAYVEFSGPESVDAALAMDNSLFRGRLIKVTSKRTNIHGFTRGRGRGNYRGGYRGGYRGGSFGYQPYRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN65</accession>
    <name>A0A2R6NN65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001067">
        <property type="protein sequence ID" value="PSR73723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN65"/>
    <dbReference type="STRING" id="98765.A0A2R6NN65"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="76"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="164"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="35834" checksum="85F680564935BF22" modified="2018-06-20" version="1">MFALRRNVLAVSNLIARVQPRTFGKRLLISQVPVAANRSLNTFAQRRLLSSQSRRENEDELEAETSSAPSVTGGLPQIFVRNLPFSVDNEQLAELFKSCGPISWAATRTGADGRPAGYGHVMFESVESVQAALKLNGYELGGRAVYVEQARGQPKTAEPAPPSTTVFVNNVPFDATVEDLEETFGQFGEITVRAPQNDQGGMKGYAFVELSDIETAQRVIDELNGKEFLGRELRLQFGRARGSGGEGSRRGVGLGGGRGREGSFGRDQGGGSFGMRGGGYAGGEDRGGYGGGRGDYEGSGSGGGRGGYSRGGGGGGYRSGGRGGSGQRDGGGRGYGIRDGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNJ9</accession>
    <name>A0A2R6NNJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNJ9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="16147" checksum="189C155B03A00BA0" modified="2018-06-20" version="1">MAARLASQALDLSVCPDLREFEFRMPMNGADQTRRVHWLVLCTLLQHISPRTNPKLQLHLILSFKSISWDKVKSVVEDLELMSSTLLGQLLRQVVSVDITIKSDSSTGGTAYIQSELLFHAFDMAFPRLVEEGRLRYKKVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPB7</accession>
    <name>A0A2R6NPB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000996">
        <property type="protein sequence ID" value="PSR74313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPB7"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="201" mass="22423" checksum="202570DB01D7409B" modified="2018-06-20" version="1">MISVMVSKWVGDALGKDGIYAVWIAMRQYPWLPPGEYRDQGQTAAQIMKPVENVVVISDEQGMTLQELGAYLEEYGYHGYPVVRGEMLIGFVVRDKVRAYIETLVAKETAENALRRCTFSQDIAAANPDMVNLSSLLEEAVLQLRKEVPLQLVVNMFQKMNLRHVLFSQGGKLTGLVTKTDIVWLLTAHLPHTAALSGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ00</accession>
    <name>A0A2R6NQ00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ00"/>
    <dbReference type="OrthoDB" id="2804605at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="495" mass="52391" checksum="92CD3C845AE31071" modified="2018-06-20" version="1">MSSGSTLPQEGPSNSHSTSPSPPTGGNRRIRSKVHEPLITMSPGSSTGPGLVNYLKQLHGLTKKRNYGPKASKRNSAAEPSRATGSRPILPRLSLPAPSAQVPTWPVGSPKVTPPQSAAETSTSVVNQRYTPIAPAKRARPTSPGAPAEQEDGRGRRWPWIKPGSISPPVKEPTQGTSTDHALRSLEAIPPKPPALGMRLPDEIEPPVQHASPTVYDTGHAQTTLPSPHEQPPTYPAYGSYSESSSQHHEEQTFSHSAANNSFPTLNSAFTSGAQTYSGMNGYHYNPPIPSSSQPPAPHMDSLHQPSSSALSYQPDYGYPSGFAPAQHDYGVSPTSSHHSHNGTPLPSPSLTSPVGPAVDEGEDQPFVITPEYEAFANAQFAEAVRSGAMQASMTPGVLTPSVAGPYPQSGGYFADPMLQHQETMIASNPALQQGAMLSHANYTYAGSSYAGPSHDDAFYHQAPGIAVPEPGSSHAYYTHGDDPSAQHPQWYGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQD9</accession>
    <name>A0A2R6NQD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000957">
        <property type="protein sequence ID" value="PSR74765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQD9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="296" mass="32286" checksum="F7CF9D2C941FF99A" modified="2018-06-20" version="1">MADWLLSKALSLNEQNPDVLLQKMTEAARISLDNSYLNCGCYHDLPWINSLRRLHLRKIHPQSVYSLIDVLDQFKFINTSPSHPLEYSDLLDESGKVVAVITGEGVKEDYEKAKAKIRENLDWMTEDLAGGGCDVGEGVIVIVDDHPHPCITPGDDGPSEGTDQEEGEVGVVLDAIIPSSESEPAHKGVSTEIPTMAAIKYAGQMQTPAKNGEHAEDDTSPPMSRSTHPSASTDERASDPRNPLSGQFEGVGSAGVHDEQTGIDSEEGIEGIIRRDVNGRQIEMQEMSTMSRTEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQI1</accession>
    <name>A0A2R6NQI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQI1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQI1"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="41891" checksum="AE74921D5E74F6E3" modified="2018-06-20" version="1">MALPATSISSAAPRPSEDVDVDMTSDDSENEEIDQLDSDTTEEEEIPIGDTLSPTSKARLKRAGERVPGQSIIPAARIEHILGAEGVGGHMSKEAIYMLSIATLRQLSIVQNFSSWKVQSSFAAQLSYVTETISKSAETIPMPLTLAEALERRAAKARELLEPETAAPTPSIHSPMPMPTSISTPTPLVIPSASQSTKSKGKARQPDAKTNGHTKNSPDHVNASIAVAEASASSAGASASASTAPVVARRQSLREPKPRRRPDEQDDKAVPNTSGTRTRSTKATRAKADTPSHSRRSSAARNGQSASISVSATGGYEDMDGSRSASQTPSAPAPHLPPEYVEANAAVSANREQAWTSIRGSGNGLLGSRPLMFNGRNGITDNPGRTIYSQQRQPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR07</accession>
    <name>A0A2R6NR07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000931">
        <property type="protein sequence ID" value="PSR75090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR07"/>
    <dbReference type="STRING" id="98765.A0A2R6NR07"/>
    <dbReference type="OrthoDB" id="2717295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="523"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="959" mass="109445" checksum="8C75AEF36E3A8737" modified="2018-06-20" version="1">MSCLHLPTLFPTIPPLLYCAPQPRQHTVRRLELVQPLLELALIQEPYIDWLGLTRANSKWNVIYPTGHRDKEKTDKTRSAILVNKRISTNDWDEIGIDSSDVTAIRIRTPSGPLYIFNVYNDQTHDRTVGKLIRRTAELEREETNRGEREGQNRTQLPTHFLWAGDFNRHHSFWEREENTHLLTRAYLDAAEPLVTALATFDLVQLLAPGIPTLQANGTGNLTRPDNVFASPALAEQLVTCNAHPALRPPNTDHFPIHSHLDVSYTESGEMPRWNWRKVEQADFYLALDEAVKGKDFPHSRIKTREEFDRTLEQLTEALVEAREQTVPKVKPSPFVKRWWNADLAKMRYKVQKLGRGAYNRRADAQHSVHTEYRKARNEYGEHIRKAKKEHWEAFLEDVDGESIWNFSKFAASEHTDGSRTRIPQLQTTGAHGRTKLSKSNEEKSKALHETFFPSPGAAPPNRDNGEPPEPAFEFKGITKDLIREVIKKLKRYKAPGIDDFPNEVFIWCEDILVPILYYLFRATHELGFYPDLWKISRTLVLRKPQRKDYTLPNAFRPIALLVCIAKILSACMARILAIQTEKLGLISNNHFLGRMGRTTTDSLHYISTTVKNAWRTKKVASILFLDVKAAFPSVNPERLLCILRRKGIPKEIVEWLKLKMTDRRTVLCFDDFQSSQFVIKGGLEQGCPLSVILYQFYNSDLLDAANRKDGETATGNIDDVAVVAVANDFEGTHDILRKYMTKQGGAFQWAKEHDSSFSVEKFGLLNCSHALRDLGPVLRLGSGFPVIKPAKSHKFLGVLVDNKFRWQAQIEKARDKGLQWLAHFRRMANVKHGISSRISQRLYFMIAIPSMLYAADVFLTPIQTRMAQESRRTGSIGAIQRLATVHRQAAMMMTGAMKTTATDVMETKSVIEHSPGCARSRKPTPSSHWYIEQLNTILESIDQRSMNLLTSTSFGQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR73</accession>
    <name>A0A2R6NR73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000924">
        <property type="protein sequence ID" value="PSR75145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR73"/>
    <dbReference type="STRING" id="98765.A0A2R6NR73"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015215631" description="Hydrophobin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="236" mass="24774" checksum="C1A725E3A00431D2" modified="2018-06-20" version="1">MYSRLSFTLILTGLLSLTAHALPCNEHSHTSEPWYPSASPYTPTPTPEPWSTVPTPSWSGPAPSEPAHSRTYTHTGTYTARHKHRTTLTKTQTRTLTSIESDWTTATLTWTTTETDTVTVTATDISTELPTPTAYQPSLSSVYTYTTTVSATGTLTPSGTPSSGSSQCNTGPVQCCNSVQPANAPDASNLLGSLGLNLQDDVPVGLTCSPLNVLGIGGAGTCAATPVCCENNTYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRB5</accession>
    <name>A0A2R6NRB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000914">
        <property type="protein sequence ID" value="PSR75235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRB5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6855" checksum="68830C7F4684549B" modified="2018-06-20" version="1" fragment="single">ELPYGKGSYSTDTCRKKYWRHRRRSVALRRPKEQAPRYALPWESSLSRWPRDGLASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRQ2</accession>
    <name>A0A2R6NRQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000903">
        <property type="protein sequence ID" value="PSR75416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NRQ2"/>
    <dbReference type="OrthoDB" id="2795925at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="28432" checksum="BA326165808E4561" modified="2018-06-20" version="1" fragment="single">MPSDSVRNDRYRAENYQTCPHCGLEFHIQGFTRHQRSCKTRKQAALRDRELAAELAKISRQERLNQLKQQRNARVRTTADNNAQQASGSAHNTSDLPDSIGVDNTAGPSNSAGGPFESAARPDEFAASPWTDGNPNTVDDDLVDSVREPDDIKVEYHPKTKIPAKIYRFGDYGRDRNVPPASAFDSDPWHPGFDSRLNFEFAELILECAMNKKQIDRLLSIVRCIADDPSQFSFTKYQDIKDAWDIAGQAHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS86</accession>
    <name>A0A2R6NS86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS86"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="109" mass="12158" checksum="D380230C72337EFD" modified="2018-06-20" version="1">MSGSNAEVLQEFEGNLVYDYINYAMTGQYTTFNAYSSIIVNPFAIALVAYEYLLSIDQEVALIWRRKWTGATWLFATNRYLLIANVVVAVLPGVSQVPPLLSIASDQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSD1</accession>
    <name>A0A2R6NSD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NSD1"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="866"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1085"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1397"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1530"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1652"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="690"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1397"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1407"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1663"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1714"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1738"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1753"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1763"/>
            <end position="1785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1854" mass="197856" checksum="4E43D7CFFDEE118C" modified="2018-06-20" version="1">MMFQAQQQQQHQQFNPNAINGLGGPNGAGGLSMMQAQQLQHMYKYGQSNSGNNSFNPQMMQAAFNHAQQQAGGQVGGNAPMGVNPQALLNNQSAMNANMGMNGMSLNPQQMLLQQQQQHQKAQQYRLSNPSAGGSSMPSGINPAQLLAQQSSGGGMSGMGVNRMNGGMGAMNMNGMGGINPQNLTMSVNAVAGSQSATSPQSPHSQSSMANPSMMSSSHSSSVSSTPAQTGNPQSIMSTFDPSQVQYLMGLSGEERSKEAQRLLATRFAAQNQQQNQQGMDGMNGMSFTVPMSGSSGMQTMGGQGGNGLNMQGQGMNMNMQNMGGMNGMQSIGGMQNFSAQQLSRMHAIQAQHALNQLGQSQGQQQGFERPSSSASHLSQGAGQPQQASPTQQHAFLHQGLTQGHSPTRSQTPQMQHQAQMQGHPHHPSQQQQHPQLQAQMMPPPSSIPPRPPTTQPSPAPRPGAASGMHGVPQHHQQHQQMQQMQQQQQQQQYMRAHAQSPRPGTAGGGAMPSPRVNTHSLQSGQQHQGQGQQSHMQVTSPQAPVPIPIQPRPPVASQLGTSPAPPPRPGTSQSMRALTPSNTRAITPSQVMSRPGTASGYPQQMQAQPQGHPQHSQQSPTQGQPQTVQMQHQAHTPTTLTPTSATYPPIAPTPVPGSPTRGAKRKAGTPGPSSTGTPVPPQQGQSHMQGQVPPQQHGQTQAQQLSQGQMLAQMQGRMPGGMGGGPGMNMTGNPSATSGMTPAQLASMRMSAGMNSANMMAGLMGGAGGGMMGPPVLPRSQSLPQVDMSLPGMNGINGMGMNGMPVQSISRQASSGDLRDIASAATSPTAANVAGLSINAGLNQSMAMGAGPGGINSMSVPSASSMMMSLSSSPNPAMLGAGPSMPSMDSLPIAPSTPRQPSQPPASGSPFLQTNMGMATEKKISGQGLLVNAAPLGRMSSGVSSDAAGPSAMAPSSGTSAAAAAASTAGPSVSSAPTVIPQLPPLPANVSLNPKTTRVSVVPLIDSENLIPQLAPDEIANVQKWMQVDKEYEGMYKKMRDRMTEEVRDVVVKTRPWWEKDPLADARGNRRRRDKFEIIGMKGGKDERSRRKLGKREGFKLPRTVDPEGASRPEQLVPIRLEFDVEHHKMRDTFLWNLNDPIITPEIFAQSVVDDYSLAPSYHAVITKTIQDQLSDFKSHSTFFGEDGIPNSPVEDVSVKGSFDDEDAVWWDAWRQNAQKDVNYKKVSGREEAHSRKRRKIVKDEVVDHAEIPPAVEKDQPMSVDDFEEDDSKALEEMRILIKLDIIVGPLKLEDQFEWDLDSLDPSPERFAEVYAKELGLGGEFRTSIAHSIREQAQIYQKSLFLVGHPSDGTMLQDDDLRMSLLPSLHTGARSMDQVGAFTPILSYLSDSEIERNEKEREKELNRRRRKTTRGRRGVALPDREPPKTFRTPAIGFPEVDAATLAAVNAAAAPTSRRAAAAAASLTIANMVASENGTAPITQNIPIPAAPSAPIVLKEKKPKGLFKAPSYSPTVLRPRAHVVAPIASTAADPSTVPPPSETDMPVSTGAPESRGARVVFSAKRVKELEREAKEREYVDGQHANYIDGVWHCSNCGCPESIAIGRRKGPLGDKSQCGVCGKFWHRHRRPRPVQYNSDLEYHLGLKRQEEQARIAASRKKRPQANNAIEASSSKAPTVEPETPMKPKSEAWVEIPSFIPGPPEPSTASGDVERAASPISTASSISEAPLAQAVKTNGIGHSTQSAPASTTVDSPPASTEAPATPNPGPPPTPASAPPTARPPPPARFKRGTMPPWLSQAMAEMQERYPDDRFEAILRVTTGMAVWRIKCLDCPGKFKQGRSNMVNIPIEGVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSE6</accession>
    <name>A0A2R6NSE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000873">
        <property type="protein sequence ID" value="PSR75843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSE6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="9655" checksum="5F55F610C91EF692" modified="2018-06-20" version="1">MAARSPSSADSNSARNDTDGVDDKAVEITYDSQDVHLAGTVRWKTDLWVLPIASMIYFLSFLGSSLRTLALLPAGFFSGLLKVAYASGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSN5</accession>
    <name>A0A2R6NSN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSN5"/>
    <dbReference type="STRING" id="98765.A0A2R6NSN5"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR75938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="447" mass="48319" checksum="30AF5370CF0488CE" modified="2018-06-20" version="1">MSSFKRRIPATQKTLPPGTRLLSGSSTTFLTSTGIPSLDDILGGGLPLGCSQVILAPDLHSAYGELTQKYYVAQGLAAAQDVYVVDDEGIRFVEECMWMPGSAASSSSVVEESEKNGGEAGEGQDTKIKIAWRYEQMKQFQTTVSSSNQSDEDFCRVFDLTCRIPAAVIQSAASKKQLVTINVSNSNPEERPLKGVLKKLTELLGPEDAEAPVQQPVRICIRALGSAQWGDVLPHDICHFLHTLRSLLRSHSNASASVSLAPHLCVDSWGGPGWIQKLGWLSDACVSLSAFTGNPSLAAMFPSHHGFVHIHSLPSPSGLLPASDKFSTLRGLTSSGENNLAFKCMRKRLVFETLHLDLEGGVGERRTTPADTISDIGLKNMHVHTHDEVPETGAAGGATVEIQMEQLQHKVAQVSMAENVPLGNSTKKVKQKKKVAFTSERPDLYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSY0</accession>
    <name>A0A2R6NSY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSY0"/>
    <dbReference type="STRING" id="98765.A0A2R6NSY0"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9203" checksum="D554B8F9355AE97E" modified="2018-06-20" version="1">MADTKQSIPEDIQSPNISTAETQKDAKQRPGQSWKQDEEHVLPHNRLGLVFFGLMSCTFLAALDQVGPLCLRSSSDDLTTARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSZ7</accession>
    <name>A0A2R6NSZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000863">
        <property type="protein sequence ID" value="PSR76085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSZ7"/>
    <dbReference type="STRING" id="98765.A0A2R6NSZ7"/>
    <dbReference type="OrthoDB" id="2804327at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="205" mass="23323" checksum="28C6EC755E139DD8" modified="2018-06-20" version="1">MESESGLAGVTVMLIDEGITEASTTGVRGQEWINKVKNTLTYLKDHHLTWGDIIEYILDPQHGKGQERWEGFFHSPRRVQQILNWWSSSRNSKTGRRTLQEWAVSYVAGAVGKEGHAATKNGLLQSRKMTVDELFAMGFDIKRLYGQLDAICPTITRVLHAFSTTAKQRQNNKEGPIQRKVRMWVPHYCCFWESGVKPIATLNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTS1</accession>
    <name>A0A2R6NTS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000846">
        <property type="protein sequence ID" value="PSR76416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTS1"/>
    <dbReference type="OrthoDB" id="2987506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="228" mass="25453" checksum="60499C128E11A690" modified="2018-06-20" version="1">MATYSVTANLDPDDFTKVSQAGYRLCIAKQVNERYYVVWKSVEDYYQITPFQWQSEEFQVFGSVKSGRRVEFSTDTPNIKFGETCTLDKNGVMLPAHGPSEPESGVFHVQNNFGPIFIGANAKLLGGDKWLPVYLSDQPCVDGNFDLVPVEKALIWFDLTSSTCDIIQKPIANCIEVCHSNPICVPTSSELIILALQVDFTQSTAPQAVEYTVIDPTNPGEGRWKRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTU8</accession>
    <name>A0A2R6NTU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTU8"/>
    <dbReference type="STRING" id="98765.A0A2R6NTU8"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7425" checksum="D38D08282C9A2F60" modified="2018-06-20" version="1">MQDAGPESSQNAASFLRRLAGPSIMKAGLAKDQTEINRVIAEASKGSKFYEVRESRELWQVILISFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVH6</accession>
    <name>A0A2R6NVH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVH6"/>
    <dbReference type="STRING" id="98765.A0A2R6NVH6"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015331302" evidence="2">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="21744" checksum="BF3F47F89790B5DE" modified="2018-06-20" version="1">MRSGLAFSLAAVITLVSHAWGQTSLYIPGFDPQPVAANELGVGADGETTWLLAPGVSSGTLDGPDIFGPATLIAGPTQAHLIYDDPAGYSLDDDCGVNGDIAECTAVYANSMTTSTYITEETAAPFEVQGGLSSTTSTDSGPPTSAPSAGSSVQTGASQTSVPSGVSQASTPGASTQSSSTSGAPLPSGSTNGVAKFGHGTLTAWLAFVASLTFLTFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVP2</accession>
    <name>A0A2R6NVP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000785">
        <property type="protein sequence ID" value="PSR77679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVP2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="133" mass="14670" checksum="35A7AE476350E9C4" modified="2018-06-20" version="1">MPVKNRRNGLSRKQANPIVYSNSLGSQLSDTPSTSAASSPPDRIPGFTPEPPLSEAAQDAVPEPTTENVDSMHLPLEYMRDAFHLRRELDHPPDPIVSKVLSPRRPIVEEEPPLVDISEPEVQGHVRSPLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVW5</accession>
    <name>A0A2R6NVW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v7653</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000768">
        <property type="protein sequence ID" value="PSR77911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVW5"/>
    <dbReference type="STRING" id="98765.A0A2R6NVW5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR77911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29459" checksum="7347B1659B7F8F7B" modified="2018-06-20" version="1">MTCDINEVAKSLSNAGAVGAYLVDIFPVMLYLPEWLAQWKREGRQLHEKYSAMLEGLLLDVRSRMQTGGLKPCLGASLIEAEGRNELSKRESAWLAGVMFVAGSETVRVRTIDHVNDLLNASVSQTASALSVLLLAMMLYPDVLKRGQDEIGIVVGTDRQPGFQDQNDLPYINAIVKEVLRWRPIAPLERFLGGNGEPAEFIPQTNTQNHFPFGSGRRICAGMNLAYQSLFINTAYLLWALNIRKPLDENGEPIVPSGTCIDEGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVY8</accession>
    <name>A0A2R6NVY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000767">
        <property type="protein sequence ID" value="PSR77937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVY8"/>
    <dbReference type="STRING" id="98765.A0A2R6NVY8"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="339" mass="37583" checksum="959615BCB7E95A1E" modified="2018-06-20" version="1">MLTPTLIWSALSKTEEIRHLTTLTRSATTEEEDDGSSEKERKEWTVEKVRSARGDQTYDSRADGEGKLSMEPGLEDRSARAVKRATDDSIARSSGAATETKGKKERVVINQDGFFGEDSGEDDDGDEDMHDPHSLGFALYILGTINRLDGFQAGLARLIHNDRYLRHEVVAPPGQDGKAGRFTFVCRHPEASTLLTPFRTQNVPPLMSSLQLPLTSSPNTPKHTSRLPSHVSFTPNKNVMTALWESDYRVELTDLHTCLECGPGKVMDPVKLSTRYAVENQTNKVYRQILALISGDALLLRLAVSGSENKPNGKIYLVVLKEKRSGGALKLFCRRVMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW08</accession>
    <name>A0A2R6NW08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000770">
        <property type="protein sequence ID" value="PSR77858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW08"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6586" checksum="CC226111817A8EBA" modified="2018-06-20" version="1">MINWRTKAGNVRLTSKDIWRNHLFFGMDKDPIIGTTQPNTHGKKNDIPYTKTSAQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWT8</accession>
    <name>A0A2R6NWT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v7381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWT8"/>
    <dbReference type="STRING" id="98765.A0A2R6NWT8"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="66"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR78634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="19959" checksum="EA2EFC3C54EB486F" modified="2018-06-20" version="1">MPILGLDTSLYPKKPAHFDIERVIRPNILSLHPYRCARDDYSEGILLDANENALGHSIPSPSRVQDPSVALDKELEHTLDMDLHRYPSPTHDPIKNRIAAIRSLPGPEYVFLGVGSDEVIDLLMRVCVAPGKEKIMTTPPTYGMYAVCAQVNDVGLVKVPLESSGAGGEGGESGRFSLRLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWW8</accession>
    <name>A0A2R6NWW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000726">
        <property type="protein sequence ID" value="PSR78754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWW8"/>
    <dbReference type="STRING" id="98765.A0A2R6NWW8"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11385" checksum="EAE8777D44E6C5F6" modified="2018-06-20" version="1">MSSGSLVLVTGVSGFLGSHVVTELLKDGYRVRGYAYRQSAFCLMKLTEFGRTVRSKKVAFVQAWYAKYEGKVEIVAFDDLIAGDITDALKGLWVSVLREKTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY16</accession>
    <name>A0A2R6NY16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY16"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015359151" evidence="2">
        <location>
            <begin position="20"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="391" mass="38010" checksum="ECC7C7712BB4A554" modified="2018-06-20" version="1">MHVFSAAISLLFLAHFGVSIPVLYPRQGSVTIVNNLMCTILGQRISDPVATLAGVQSSVIASPEGLTTDEFSDLLRDCISGGSGHNRQFTGIGEDTEDDGVEGDSDPDASGNYPGYPGSGVSPDSNGNGGNTNTEATADNSANTSAPAGSSPPPPTDPPSTNGSGDGSTDASGGNGNSGDDSGINSGNGSPSPSPTPPLNPDPSAAVHTLDTAANANGDNGNTANGDNDTTADGDSGANANGSNDPNTTGGSGANANQDTPAPVNPSAVPASNGGNSPSDVPASTNTDPNATPFTPYPETFGSTLTPAGDDAAEDDNTDGSDFGFGRGDRGSGSHSSSGCTGLACLAEGVTPAGLVAAPELGLDGITQGSPSKCPKGDLGLCLDLGTGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY77</accession>
    <name>A0A2R6NY77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY77"/>
    <dbReference type="STRING" id="98765.A0A2R6NY77"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="9591" checksum="2BEBD1A9AECAA681" modified="2018-06-20" version="1">MRRAVLEEPPTEWEKWHTQHCLNYVRQMILCESNLRLEQVKDSPVGLKADGLGLEHTCRDWSILYDIAEENSKHWPEGLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYS0</accession>
    <name>A0A2R6NYS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v6624</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYS0"/>
    <dbReference type="STRING" id="98765.A0A2R6NYS0"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR80708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="576" mass="64492" checksum="4D3EFFD48C48972B" modified="2018-06-20" version="1">MSLLAGYSSDEDDGPSSNSNDTFGLSSIPVTKRLRVEEPPSGLIVTAAPDVLAEDPLHQTSLVLRPTDTRMNVNIPYAEMTLPLQGPENPFGDRNRFLNQNALAGHVEEQSMTEHAFRQQHLTHSILGYSANPSVDPNAPAVLGAFEKAQANGFATIDLIKAPRAEKKELKRKRNTRGDLEVVDGEGAYQGPWATWRGEERQDTLPEGVEEAEEEEEEEEPEEEVQVRKAKPKRGAPGLESSVFHGKSLTDYQGRTYMSPPISEAPQLQSEAGSQETFIPKTCIHTWTGHTQGVSVIRLFPNTGHLLLSGSMDTKIKLWDVYTHGNCLRTFHGHMGAVKDVTFSNDGRKFLSCGHDRQMKLWDTETGQCLKRFSNGKVPHVVRFHPDEDKQHIFLAGMSDKKIIQYDMNSGEITQEYDQHLGAVNSITFVDDNRRFVTTSDDKTIRAWDFDIPVVIKYIAEPHMHSMPAVTLHPSKKYFAAQSLDNQILVYSTDNFRQARNKRFAGHMVAGYACQVGFSPDGKWISSGDGEGNVVFWEWKTGRIKSRLRAHSKVVIAHEWLPHESVCDPTLEPFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYV8</accession>
    <name>A0A2R6NYV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v6642</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYV8"/>
    <dbReference type="STRING" id="98765.A0A2R6NYV8"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="13">
        <location>
            <begin position="152"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR80726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="318" mass="32255" checksum="B2931DCC3E4F07A6" modified="2018-06-20" version="1">MSVSSEWCGDAQPSAYADKNGAFAGYNIPAYFSEFGCITSPPRLWTEVATMFASPMTDIWSGGLAFSYFPATSSQGQFGMVTISSDNTTVTTSDDFTRLQAEYGNVTFVNSPSAPGSTTFPSCPTANSTFLASQSLPPTPNDNSCNCLESSLACQFTPTTSNTSAIVGPLLDTACGLLGQVNGNCDAIAADGAAGTYGPVSFCNPSIKLSYVMDQYYEATNRVATSCSFGGNATINSQAPSAASASAAASSCLSNPDATFVPSPPATLSGSSPTGSSSGSGSSGNKDNGASTLSNKEAMMGMVLATVFSVAGGLFVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ38</accession>
    <name>A0A2R6NZ38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000630">
        <property type="protein sequence ID" value="PSR80983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ38"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43436" checksum="EEF0F5230B3F2C19" modified="2018-06-20" version="1">MSCKVPLELIDMILGFLHDEHTTLGSCSLVCRSWTNPSRCHQFYEVEVERSQLFTSFKQLVLASATISDSIRELRLLDSVVPPYPASPEDLSFLLDKLSKLHTLRLWGLTLMYPRRPGFRWNFAKLRVLEISGLTTMRSGLIRVMSLFRGVSLDRLRMEDVDLHNAGPPVRKLVDDQLARWQIGSISLGRNGCTPDLLELFGSMHLEALHSLDVGYMPTGVERASFEAFASLKGANLQHLRYTETWRFFENFTSLQSLHLFLGGEWLYGRSGRVEDTTSMFPTLILQHVPSTLKAVTLAFEIDYDGSFIQSWIDCVDWEYLEGTLLSFKNLKAVNVVMECQSPAPFWDHRIESIPQKRQKMIAEALPKMHTSGILYFPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ46</accession>
    <name>A0A2R6NZ46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000626">
        <property type="protein sequence ID" value="PSR81097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ46"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ46"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="58903" checksum="87CD28FF7FF530B3" modified="2018-06-20" version="1">MADIPTPTLNVFAVSRKRIFPTSQQPSGLVRTTPLSILDESVLRFAPSACVWIFSTPTLAREKMALSHAHLENTLSQTLGSYPQWAGQLHWSSSKTVEAHGVRPFGRLAVTYGSVTDDPGVEFVAATCPHSLNSLLPSSTPGSRTGTHWRNATSFPTTELLPSTPLALNNLKDYLGLPSMIVQITDFACGSVGVAVKLAHPLADAQALAHFVHDWAKLSRACMSDPISPPPLPVNPVFEPSKLETAIGGPSSLTGPHPLPMHHYDWWASESGCPEFMKGATRPPTDSEVEGTYGTPIPWTEWDPTAPVSHYVLHFDRDGVQRLWEEAISSLSISRTNGVDGRLSRMDVVLAYVWGLILRARGLETDDGPVHLDVTLGMRTRLSPPLPDSFLGSPIILADVLSSARSACLGSENGLTASTIRSTLEQFGSNAVHALLHRMLTEHSPPWRYWQAFLGERHAIVTSWARLGVYDVDFGAGQRPICVEGVMPNVDGCVQVMEAQPSSRLDSEERKKGSQWYDDGVDVNLYLRTDVLEELVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZM6</accession>
    <name>A0A2R6NZM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000619">
        <property type="protein sequence ID" value="PSR81413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZM6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5896" checksum="B8040A9B94928EC6" modified="2018-06-20" version="1" fragment="single">MSANPEDLSYIHRRCVLVDKLVSLEWAHPPYDTQGRYDLPLISVCMHRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZN3</accession>
    <name>A0A2R6NZN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000618">
        <property type="protein sequence ID" value="PSR81442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZN3"/>
    <dbReference type="STRING" id="98765.A0A2R6NZN3"/>
    <dbReference type="OrthoDB" id="3344688at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF440">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7658" checksum="668148C54BAB8D27" modified="2018-06-20" version="1">MAHGLQLVKAGPSHEANPELCDMYQSMIGTLLYLMLGTRPDISFAVTKLSQFMFNPTLSQWTPPPSHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0H2</accession>
    <name>A0A2R6P0H2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000587">
        <property type="protein sequence ID" value="PSR82397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0H2"/>
    <dbReference type="STRING" id="98765.A0A2R6P0H2"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF24">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR82397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="362" mass="40957" checksum="39EBD8C622B97C54" modified="2018-06-20" version="1">MDLWGPSPVRAPGGFQYTFTILDEATGWLHEPKMHTKDEAFGQFVAWHWQCFMQSVIRIKMVHSDCGGEFLSKDFTNFLEKEGIVQRLTVHDTPEHNGMAKHVHRTILNTVQTLLAESGLPPFLWGKAHNHTVYVYNYSPQSFLQFKTPFEAQMVTVIYLTNDIVAGEPSKEDLQNFDLPPVDDDDNDNMPNLIPFDDNPIDDRSPELTPQIDQEPTRTSNDNQTFESPPIPPISKFNQLRPQREKSPSAKVRALTDGTGITGEEFDHANNFLSANIVYATLQVGNDPANMKEALARPDNQQWMLAMVEEITRLEARSMFTLLPMQISSAPDLFTISRAMNMAVLPNTVHDLSLKDKSKSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0R3</accession>
    <name>A0A2R6P0R3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000578">
        <property type="protein sequence ID" value="PSR82695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0R3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6682" checksum="EB1EFB47B7283211" modified="2018-06-20" version="1">MVSRLYLNKNIRSTAIPDNSCQGSLLRPQPLFEPGRPKLLQMLSHLRRWQVLENVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0V4</accession>
    <name>A0A2R6P0V4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR82019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0V4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="8117" checksum="470273C9DE44C7BC" modified="2018-06-20" version="1">MAGMLDSRRPADLVPLLSEWLPVGWYSIAPSLEACGTWYGGARFFTNHNQNKVWRVTSRFVNPMMNQYALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8G0</accession>
    <name>A0A2R6P8G0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000521">
        <property type="protein sequence ID" value="PSR86937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8G0"/>
    <dbReference type="STRING" id="98765.A0A2R6P8G0"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="379"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR86937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="545" mass="58223" checksum="E7F41D547AC9DC00" modified="2018-06-20" version="1">MNIDSPAYDASEEDNDPLTDSGASIVSRSSFSSNTSIRPPSTATSASTGAGTGAAIRARGTSTSTTTPLSRAGAARGPVGIVGTGAGRHLAQLSGISSDVDVDSGVDSPTYDGDIESSTTAGPDDRVHLPTSQSSSSYVHTHAHHPPSTFLSSPSSAASTGPTYSHGARSHREQQQQQQPSVLSSTTSSSLRHAPNPSTSPTKRSLVSPPSPSSNTLPKPPSSSHPHSLPKSSPSPPALHRPTPMHPSRPTEPVPAGISTAAFDPAKLTPEDVQLWFREMIDGPGCTVGDKTYKINEPPTERPVRIYADGVYDLFHFGHALQLRQSKLAFPSVPPVREAMTAGTQDATQGLDRERADGRGAGVDGERRDAEEWTPGVYLLVGVNSDEQCEEHKNRTVMTHAERCEAVRHCRWVDEVVPEAPWVIDGPFIEKYKIDYVAHDVDPYGSAGLDDVYAFCKLQGKFLPTRRTPGISTSDLLARLVSGYRHRVFDKKLAKMGMHALMAEGSDWDESASVSRAESRDVSRRVSRVGSPILEKVPCGFSGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBU7</accession>
    <name>A0A2R6PBU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBU7"/>
    <dbReference type="STRING" id="98765.A0A2R6PBU7"/>
    <dbReference type="OrthoDB" id="2745837at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="649" mass="72555" checksum="6EEF7ACDD5E57A4F" modified="2018-06-20" version="1">MATSSSPSLQSGSILKTPHGEATEVTIQFFLTHVLPLLPAGMDPASLISKNPRIPRAVGKLITGKGRLWGFPQDPSKLGKAERKTYEALTRSAEAIATTGAEEGLRQTVHLQHNKKGISRFDKRHEDTTFPDAYMLSCAGSDREVIWSHIAISGAYHKKNTIERAKEDHFFLIHFFSSIMFADPHQLGWDPTMKVLADPGQSTQYEIIVRSESGEEKTYRTLDSLSDSSTERLLGRGTRVWKAIRTQDGKDCGEPVALKDAWVDHDRGREGDVFTRLRQSSISAAHTVVLDKCFLTVQSHGDVFISDHQDCTWISPISQATPTVSHAPVVGPSGAIFADIPQDRRQVHYRVVFEEIGKPLSRETSLCTVFKIVADAAVALLAMHKCGWVHRDVSVGNILIFDDIAKIADLEYATNADYAGVLGQTGTDYFRAVEVDCSHYLFADVLRHRRAAKKSAGPPSPAALAAYLSGKLPPSAPRPPRRPLFPSKPFAYNPLHDLESLWWVAVYFVINKGIVHCDDEESEDFQSRSADQRTFARQLFYDQHTRHNVMVINSYFSTKLSCLDPSLLRIGEILEDTRSALVDAYCRVESMKELEKIDITIVEDVHSIIQDNFREACDILESSDIQVARFEDTKQGTKRKRPYTNDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC82</accession>
    <name>A0A2R6PC82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATPase V1 complex subunit H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC82"/>
    <dbReference type="STRING" id="98765.A0A2R6PC82"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="5">
        <location>
            <begin position="225"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR88861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="343" mass="39293" checksum="40E8C27D23A2010F" modified="2018-06-20" version="1">MQQRQITKSEFRSSPEHQSRMLSYHTAHCYDDFVQLKATQILTVLLSSESSPIQSQYLLPFLNTLSAFVTHPLPHKRDIAVQCLETVLPRSEVRRAVWENATLVGGLVDILKHNPGPQMCYQIGFCFWLLTFEQEVAEQLNKKFDIIPLLTDIAKAAVKEKVVRVIVATFRNMVSKAPSNNLPAMLVAQLLPFVKNLSTRKWTDEDIVEDVQYLRDELNARFESLTTYDEYSSELLSGHLSWTPVHESELFWKENVTKLNDKDYDQLKTLVGLLKESNDPVVLAVAAHDIGQYVKHYERGKKVLTDLGAKTRVMELMTHRDSDVRYQALISVQRLVSHPWAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG29</accession>
    <name>A0A2R6PG29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG29"/>
    <dbReference type="STRING" id="98765.A0A2R6PG29"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR90593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="150" mass="16334" checksum="FAE85DD3F30B6FA6" modified="2018-06-20" version="1">MKAYENGTPAYFATPPVNLIRAFHTSLTQITKANISLEERFQLHRDAAKRVRSAAADLGLKLVPVDPACTANGMTAIYLPEGLGVADLVPRLAKREVVITGGIHKENKDKYFRIGHMGVTVVQPERGDLDRVVAALKESLQEALASKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGA8</accession>
    <name>A0A2R6PGA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGA8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="121" mass="13870" checksum="E7730E45BCE18333" modified="2018-06-20" version="1">MHGTRVCPPGKIVTLYEKRYFVYVPQGAIYSPRTDEKMLIVVRVADFEFPECSETDLWLQLKCGQWKESSCPSLPPRIDCDSFTEFDRQSFKPPTDQPGRIVIVNGDSHITYIRKGVVISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN48</accession>
    <name>A0A2R6PN48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000467">
        <property type="protein sequence ID" value="PSR93879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN48"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR93879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="6197" checksum="743CE2CAAE91B1C6" modified="2018-06-20" version="1">MSQAGKLARNADRKPWAGYMLEMYYRGQKPPALGTYSVDRIEQLAREKPKDRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN59</accession>
    <name>A0A2R6PN59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000464">
        <property type="protein sequence ID" value="PSR93972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN59"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR93972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="445" mass="48631" checksum="EA6FFC669AD5E5C0" modified="2018-06-20" version="1">MVCTIIRYKFDKALTSIKAISVGADVAIVIVSIVVFVLLLAVYIVARKVYRKRKDKRHAPVPTRELDLDFDTTDVEVGVSTRGNQMGHWRGLSDSSTDSSTPLMFQDDRIWKPSIPTSHPFNAGMYPVAPTSPQVPQPTAPAFASFSSQDAATPNDRQLSTLASRPSILAHPPRTIPRPVATQRSRSRAAPDMRANLLTRLTSTRSGHKADTTDERSDSPSSMYSQSSATTMGYWELEGDHQLNGEAVPAVPALPSRFRSQDSDDQFQVQTQQDEDLTFDEGAVSASLLKRRAQAENSERLAELEESLTFPLPSPTTPTLPLPMKSPSNGLFTQSSSPPDSPTTAHSYMFPPIVIPSTPSYPIIKPLQASSRDGDVISVRSVEGSRNVPYHGDAYPRSFEDGGKGPIHFQVPPSWRVVDVPRMPTPPVSRGGTPENARVASFIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNL8</accession>
    <name>A0A2R6PNL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000449">
        <property type="protein sequence ID" value="PSR94471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNL8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="7536" checksum="3689BAA91E86F5E0" modified="2018-06-20" version="1">MLVVDALYRQQQQQLRSTPDNRLQDDLREPDEYICTLQQWLDNAKDNMAEMRRDNQRLRDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYT7</accession>
    <name>A0A2R6PYT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="3">M1Pi</shortName>
            <shortName evidence="3">MTR-1-P isomerase</shortName>
            <ecNumber evidence="3">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MRI1</name>
        <name evidence="4" type="ORF">PHLCEN_2v4234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYT7"/>
    <dbReference type="STRING" id="98765.A0A2R6PYT7"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000006">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR98914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="386" mass="41382" checksum="53F6A0AD4E2DA513" modified="2018-06-20" version="1">MVGLTSIRTTGNKIEIVNQLLLPHTVEFIEIDTVEQAHDAIKSMKIRGAPAIASLAALIVASHLSRSLEDSQSPEFLTSTESLKAHIDSILSYLFTARPTAVNLGAATRRLQKTLQAGLDAGKDARSIAQDLVAEGKAIDDEDVLRNKEMSKWGGEWLVERRKSAGSAGDALKVMTVCNTGSLATSGYGTALGLITYLHETNKLERAYFTQSTPYHQGSRLTAFELQSLKIPSVMLCDSMVGSLFQHHDIAAVVVGADRIAKNGDTANKVGTYNAAVLAARHNIPFMVVAPVSTVDLEVADGNEIPIEQRPPLEACLVRGALYPFSTNSQGLKEQATVMVTPEGLEGVYNPSFDVTPAELITAIVTEKGVAVKEHGKISFDLSSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYZ1</accession>
    <name>A0A2R6PYZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYZ1"/>
    <dbReference type="STRING" id="98765.A0A2R6PYZ1"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR99067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="835" mass="93541" checksum="60E99F863A38B5E4" modified="2018-06-20" version="1">MPEPDTNKTSPNAAQETGWSGIEDHLGKIDKSQMKVLNEDIDALLIFAGLFSAVLTAFVVPSYLLLQPDNSQLTVQLLAHISAQLARFEIVPPFINSTASNPSASPAFQVSTSARWMNCLWLLSLIFSLSSALFGILAKQWIREYLMWKIISAAPRENVLLRQLRNEAWEDWKVSGGISTIPALLELAVVLFFAGLVVLVWTLDTVVAIVITAAVSVVIIIPCTVTVLPAVYRRCPYKSPTGWACIIIFEPLIWVVRCIVRWVFNSIIILRHTWRAIARLDFSRKLAKVLRRRFVRSAVVPDEHEDDDEGSHADDELHECIWLPPFPRFSNWRERDLYIDDLGSSEISNINDIGYPYSYKTKVAKDICEVMPLVRALSWVRKGTEDPRLLNHVATSAESLHVDRVDTEARCYVFTYVLRKLYSAKSESKELLPLSKLKDQLRNKAYKTVGNGHKMFRGGIRSGSGHLDLQVDVLSLDPSDSWILSDLLLGDIMYALGNSSLDRQIMCMGLSQYFLFFFRYSREFDAGRTRLQKIYNDSLSTSHQKLRSSGVHTMILELLCSVSEVHMAKGTKLISADGFRVSGRFIDNEMRLAVQMFDQNDGYSDPYARHQFVMMADLVMRSLNDCWMQDKDLMGTLLEKMSKAVTISLDKGYRNCGCYHPLPWVGSMLSCDSDQLRWLPSQLIRSFLDVLQRSQPASSSNNEDIRGREAFVMLNNRVEGLNPRPARGHSAIDAAADPAVLDSEVEPSGRILSESVATDPDAKDDTTAGAGDVDVQQGGNDNVAVPGSQSQAAQLSERISIPTGLPAEETQENRPLSHYQCNVTIRDVELAVPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZT3</accession>
    <name>A0A2R6PZT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000420">
        <property type="protein sequence ID" value="PSR99331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZT3"/>
    <dbReference type="STRING" id="98765.A0A2R6PZT3"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="3">
        <location>
            <begin position="291"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR99331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1217" mass="140066" checksum="198707D9A783201F" modified="2018-06-20" version="1">MQQYFTSYRKPLPRVFGWSFRNPSKTSLVPQRGPLLKERHPTNSSSDTMATLDTLANGSALHTNGTPTDEPVQPTIAAFDPSIFRSYLLALIPPFLGASPDELETIFDDEFEERISRFAGEGGGVIYVVKKKEETEDEAPPAYTYVLTPQLTYHPSHVTTLAVIKRGPTLDPLSPLATQLHVLNLFGGDETPYESLHAVVSCAVKPWFEAFVGSRGAGKEGDTKGGIPMTKKKFAELELSLLHLQQNVEIPETHLIIHPAIQRAVEQARTNGSRPSLSDIPPKLLNDSSFLNTLHNHVNQWIKAIQTVTKLSRDVSSGTASQEINFWPSLERALEGIETQLRSDEVNMVMDCLRNAKRFRATVSFIADTGLKDATDTVHKYNQLMKDFPLNELLSATDLDKIQESIVLIFGHLNRKLKLSPYPIRRTLPLVEAISKDFNDQLLRVLTSHRLLYTPYDTFERLLSQAMNIFRTWDDNIKEFTNVAREMTKKRSEKFIPIKVVPAHAKLQDRVRYLRDWRKQHEQLAVMTGPTKGLSGVGMEVGGVDMEQEVKEAYEVMKRIDVLDVSLEGSEIWVAAENAYNEHVARVENQIIARLRDRLGTARNANEMFRVFSKFNALFVRPKIRGAIQEYQTQLIDSVKEDIQRLHHKFKTQYRFSEAYHMSQMRDLPPISGAIIWARQIDRQLQTYMKRVEDVLGKGWELYAEGQKLQSESSAFRKKLDTRPVYEAWLHDINRRDMGVNGRLFEIVRLRGGGFQLAVNFDPQIITLFKEVRNLLWQNFQVPHAITNMAKDAKRVYPHAVSLMETVRTYGQTLDLVENNKGIEWLVAEYRNEAQRMVSRGMNIRWDYFVNQYDSTRYVSSSETRDNRHIQFVREFASVVSVLQDKTNNVIDLYRDILRAVEDLSTCPYTSEAFSELLGRVQSAIDRLNLEGYANLEQWVTELDQRIESILLLRVIHIIQVWCTEFDRADDDGRREPLASRDIAIKRRGDKRFKDEKSLEGSLTLKPIVHEIRIQNQVIFLDPPIEYARHTWIQQLHDWLGIVCRLRRIQSSRYEIGLQMQSAVVVDTTYTSLLTKFTDGTLERPFALIENKVQQLKDYVAKWLQFQSLWDLEAEYVFNRLGEDLGHWQQLLTEIKKARSTFDTSDTQKSFGVCVIDYEQVQARVNAKYDAWQRDILSRFGVKLGNAMKEMHASILKARNELEHQSIEGLVGAPRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5E4</accession>
    <name>A0A2R6Q5E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000398">
        <property type="protein sequence ID" value="PSS02340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5E4"/>
    <dbReference type="STRING" id="98765.A0A2R6Q5E4"/>
    <dbReference type="OrthoDB" id="2730619at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043750">
        <property type="entry name" value="DUF5695"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18951">
        <property type="entry name" value="DUF5695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015306097" evidence="1">
        <location>
            <begin position="19"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="812" mass="88351" checksum="24158BF8031FA654" modified="2018-06-20" version="1">MHISQFIVLSLYLLVARSQTPTLGLPDGFITLDTPLFSVQLVKDSQTLYSLQPKNVSGGFDFIPADQMTLRQFNGNYHLGDITFRARTVGSNAWLSGDTSASRNTVTALPASGTTLAASNLSPTLPSDSLLNITRRWVLDNGTLELLFDVINSQNTSVEIGALGAPLEFNNIFTDRTAAETNELCSLFDPYIGQDAGYVQVTPLLGTLPPLVVTPAGKSPLEGWRFLPESTVNTPFYQSQTFEGLYEWQFHTLAYAQNEWANVTPWNSPSSAVLAPGQMQTYGLQFHLSPSIRSIEDTLRASGRPVAVGLPGYILPTDQLGKLFLSHSSPIRSITVSPSGALSWAPNADSKTSTWVGYTVTPHTWGRSRLSITYQDGTVQTVHYYVTKASTTVISDLGNFLTTSQWFDNVSDPFHRSPSVISFDREVNSVVRDDPRSWIPGLSDEAGAGSWLAASMKQFAQPSAAEVAKLETFINVTLWGSIQNSDGDVLSLSTSMNQILFLTTHTRQVLIGVTGGLGTKQRRTPQTELMTMYMSHFGSEMAWDSTGQEGVYAWSKYFNDTVTAENVINSVIAYQPTVPHWGYNGNARRYWDNIYGGKLQRIERQIHHYGSGLNALPLMSQYQSSPDDYYLLRVAFGGISGPTTNIDQGGFASASFHSFADTLMWDAYSGDYGPNFVGHSLGMGTFIINHPDFGWQALGGNVLSTSPVVRVQPRDTLRRRVFIAPLGTLLSLDAGAFSMITFDPTTKAVSLTIVPAAEGASSAASAPRGRLVVSQTALIPNVRLLKPSKPLTQDAGAWVIPFSSGSATVTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB36</accession>
    <name>A0A2R6QB36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000378">
        <property type="protein sequence ID" value="PSS05352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB36"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="110" mass="12067" checksum="F02AE428D54C3EBB" modified="2018-06-20" version="1">MATEDCSVDASAAGSMILPPSGVSVTTSSASSFMSGLPLWSRPAPTFPTKRAKVGGHESRESKIGKWLWVSFSGLPVEEETRRNIRIVVNLLNRPRMIRLMLTFCGKVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBJ8</accession>
    <name>A0A2R6QBJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBJ8"/>
    <dbReference type="STRING" id="98765.A0A2R6QBJ8"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015339912" description="Cupin type-1 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="103"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS05499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="34279" checksum="7005328401096B8B" modified="2018-06-20" version="1">MPGLPFKKAVVATICLATFAYSAPAGTLVASAPSSTPTAPYASENPNGMLWTEQEDITPEPIRGTLGATILGPQNVPMDLQNADLLAPPSTDSGTVGNAKWPFSLSHNRLQTGGWARQQNVQVMPLATEMAGVNMRLEAGALRELHWHKTAEWAYVLKGSMNIATMNFNGESFYDTVNPGDLWYFPPGVPHVLQATADLAEGAEFLLVFDDGDFSEDSTFSLTDWLSHVPKDVLARNFQTTVDAFDRIPGKELYIFPSTPLPKASSPQGNAALPYTFKASQMPVTPLSGGTVKIVDSTIFNVSTTIAMAEVTVEPGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QED7</accession>
    <name>A0A2R6QED7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho GTPase-activating protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000365">
        <property type="protein sequence ID" value="PSS06489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6QED7"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000045">
        <property type="entry name" value="RhoGAP domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="614"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="789"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS06489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1491" mass="163488" checksum="C3AD725685DEE644" modified="2018-06-20" version="1">MPVAPSNHLMSSSSVRPGPHASTSTALDSNAVPGTPQVQVNGMPATDGAPRRTKSSSSSSAAPESDGSGWGANFWVTLVDPQTGVSFYACPATGEVSWDPPVGNFLLPPSPEGEWWEMTDEASGVPYYYHTKTGETVWERPQTFVIPLSVLQNTALGRRLSLRTSQSTSPSGSPTKPSYQRSRSYANDREPSTSSLHPQTQAQIRRRSQSTSRPTTSPNGSTSSKSPSPNPSPHPSPARSGKQVLRRSVSGEKYSPGSSSVSPLAYERGHPLAPIPGSPYATDASPPSSPSKKSALKLEKERERGMENGKRGLDLHVNGTISSKDSQKKSNAPSLETEDGLARSRSSKSSNSANFIPYRSVQPQSLNAALEMIALSNSQQGSSTLANGNGTGGGGSGNRAAANARQSLSLGRKSGQGFSRLRVSTDPAGAPMDGKRTIQGSASTPASPALPASANLPNFAHVKTASQLGPQATSSPPKTTSALPSSINDPAAGNRQWMVGREISSPVFDREATMNMSPIKMRNAGRPILIDQPSKKSGLSQSTQGESPWDAELGIYTHRKKASLDTGLYPVLPDDLASDIQQFSETQFARQYFSTHRTGFIFRRKVPVEQMMTWQKSPLSSPLLQLNKPLHKEAVKTFKSMQRVMGDRDRDRPIHNGSTTSLLAGNALLEEERSLLGEGLAHGELRDEIYCQVMKQLNGNPNPESVFKGWQLLCVLLVTFPPSKNFEASLRNFLQRATHQPEGRIDIMAKYCLRRLSHISRKGPRGKAPTLSEIESASDAAFHPSIFGESLDAIFRLQERNYPQQKVPIILPFLSDGILALGGTKSEGIFRVPGDGDTVSELKLRIDKGYYTLDGFDDPHVLASLLKLWLRELADPLIPDELYNDCITESSDPEACVMIVHRLPTINRRVVLFVVSFLQLFLEDKVQTITKMTAPNLALVMAPNLLRCSSESMAVVFTNAHLARTCHLFYEPALDILWRELDDLSPLIKCLSSELWGETEEQDMSGQKILLELTRIPSLEEWKKVHAHAHRVRSVNLCQRRYTESGATYEISWNTLIRFSQHLRTRSYERAVPFFRYLRTLSCDYHERFLPKWAADCFHHIAGRSLVELHLLCDEDTSTAYMMNQLVDLSRALPPLSASSPNMKYVSIRDTRPYPSNKPCSGTTSLLARLRHLRHFTNSLPLQNSDVIYLAGQSKLSYLHLTLLMQQSEGPKIPQDLRISTPFHFLGTLVLQVRHVDLATAFLNLLDSPPLKKLSITTAIWSDETEIRNCLEAISARPSLQDITLMVSGSRFLSGTQPGGHCTISFRTIAVLFALGGVLSFRLTAEDRARFETDLDDIGVEAMSQAWPQLRNLSIVQGTYAPRGVVLPPVRTTMGAMLALRDHCHHLSGVSISLDTSSFETHVLQAACTGGELGHSLRKLDIGARSSPVSNPSVAAQILHGLFPRLQNIHDGSSVAWDAHYSDWQEVGGILRKLISGSELEPSECEFSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QER7</accession>
    <name>A0A2R6QER7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Rab-type small GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v3589</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QER7"/>
    <dbReference type="STRING" id="98765.A0A2R6QER7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS06633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22339" checksum="70C86E850B26C8AA" modified="2018-06-20" version="1">MATQSSPYLCTSGVGKSCLLLRFCDDAWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWHANIEQHASEGVNKILIGNKSDWTDKRAVTEEQGRELAEELGIKFMETSAKVNEGVEEAFFTLARDIKTRLIDSQVDSAGAGGPGGSAAGSDSVKVNQPAAATSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIM4</accession>
    <name>A0A2R6QIM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIM4"/>
    <dbReference type="STRING" id="98765.A0A2R6QIM4"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000350">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="92"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="398"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="709"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS08839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="984" mass="109971" checksum="10B318489A7DF2FF" modified="2018-06-20" version="1">MSSASTSPDEKERTLATDSPDNLSLVEDQHSGSQVEVHGSAVPADEHEDKHAVGDEEEGSDPESEGAETYEDDGDEHSDEDDEDEDDEEPVLKYERLGGDVHDKLLKKDSASALTYSNQLLALGTHAGIVHVLDLAGEVVKSVKPHSASIIDICMDETADFIGTASIDGQVVIYSLSTPEVYSFDKKRPMRTLALEPQFAKRSTRAFVCGGMSGNLVMHEKGWLGHKETVLHRDEGPIWQVRWRGRLIAWANDLGVKIYDTVSQMRLVFIDRPAESPRADLFKCTLYWQDDSTLLIAWADVIRVARIRDRPRPNTTPAAKQPPLLVEITAVFQLDCMITGIVPHPIPYSSHVVGPSPSMTQPLGSTIAAPVKTLTAFLVLAYTPPDTSFFNGNEVASSHAEQARKAAERPELRIINRAGEELSTDALSISGYEKWGCNDYVLVEVPSTTPGVANSYVVMSPKDVVVVRPRDWRDHVAWLVERKRYEEALEVLEKSSETSQEEDNDVDAIEIGQKYIEHLVSEGDFVKAARLCPKVCGQDVKRWEDWIFIFVQQHHLQAIIPYIPTETLTLGHLVYEMILAYFLSHDRQALLKTIKDWPNNIYDIPAVIVAVQAELERSPSSSANNTTTPDSVLLMECLAELYTANRQPGKALPYFLRLRRPNVLDLIRDNNLFTAVQDQALLLVEFDHELIEKRRKSGEQVDPGQSAAITLLVDHIHSIPIGRVVQQLQSRPYYLYLYLDALFAKDPHLTSHFADAQVELYAEYAPRRLIDFLRASSYYSLEKAYNVCEERDQVPEMVFLLGRMGNNKQALNLIIERLGDVNRAIDFAKDQGDEELWEDLLRYSETRPAFIRGLLENVGADINPIRLIRRIKNGLEIPGLKGALIKILHDFNLQTSLLEGCQTILNGDCSELAQTLHKDQTAGFLLNGRATCPICSLPLMETSQSLLLLFLCRHVVHAHCTGKTNLLSHSDVGARSGISGKIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM91</accession>
    <name>A0A2R6QM91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM91"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6405" checksum="34FA017F513D3748" modified="2018-06-20" version="1">MAKIHEINKMLQYTKRKVVRSVIALKGWEVDAVGGARRRARMGKYDCDLACQDPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXM7</accession>
    <name>A0A2R6QXM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000297">
        <property type="protein sequence ID" value="PSS17125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXM7"/>
    <dbReference type="STRING" id="98765.A0A2R6QXM7"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015333235" evidence="4">
        <location>
            <begin position="36"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS17125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="228" mass="25632" checksum="96C8ADF16FE3A586" modified="2018-06-20" version="1">MLTIVPLFLSLQVNHLSTALLALLLVPALARTAKANATHSRLVVVASDTHFWTKFGEELKPENAPGILEKLNERAYCTQEIMETRYPDSKLLNVLFTRALAAHLSPSLPIIATAVNPGFCYSELLRNVPLRRLIIMKIMQFFVARTAEQGARQLLWAALGPDGKDGEHVKYLNGAYVSTLEVREPSDYVISKDGYEAQERIWRETLFILSKGAPELQQVVEQYLRQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7G9</accession>
    <name>A0A2R6R7G9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron permease FTR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v3007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000268">
        <property type="protein sequence ID" value="PSS22687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7G9"/>
    <dbReference type="STRING" id="98765.A0A2R6R7G9"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS22687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42854" checksum="EBBD9BAD18CE7D9E" modified="2018-06-20" version="1">MGKNVFSVPIFFIVFRETLEAAIIVSVLLGLVEQIAYEDNGRSLAPTVSEPEKRDGDDSNKSEELSGQPKLESEEDKLISTKRFVRRMRWQVFLGAGLGFIIALSVGAAFIAVWFTKAADLWAKSEELWEGIFELIACIMIFVMGVTMLKMDRAKAKWRVKLQKAFAGQHVDAGAKSGKWVLFVLPLITVLREGMEAVIFVGGVSLGQPATSIPIAAIVGLACGIICGFLIYTFASRSTLTVFLVAMTNFLLLIGAGLFSRAIGSFQENAFNTLLGADVDDEGAAGDGPGSYDVRGNVWHIDCCNPENNFDSDGWTMFNAIFGWTNSATVGTVLGYVFFWLAAILCLIIMKYKEGRTKLFGYESAAGVRRRERTALSRGDSELSAANSEHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHS7</accession>
    <name>A0A2R6RHS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHS7"/>
    <dbReference type="STRING" id="98765.A0A2R6RHS7"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor C C-terminal" evidence="5">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS29586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="15350" checksum="EF2BAE8284098B68" modified="2018-06-20" version="1">MSNKIIEPIQSRCAILRYAKLRDQEVLKRLLEICEAEKVQYNDEGLTALIFTAEGDMRQAINNLQSTHSGFGFVSGDNVFKVCDQPHPVTVQAIIRACLKSDIDLAMDKLGELWQQGYSAVDIIVTIFRVVKTFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI83</accession>
    <name>A0A2R6RI83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI83"/>
    <dbReference type="OrthoDB" id="9623740at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="296" mass="31172" checksum="224EFE2657A57013" modified="2018-06-20" version="1">MEETGGDGRKEGMVRDGRIEVTGRDGRIEATGRDGNIEETGRDWTSMGRDGRIEVGRGGKMEDMGRGGNIEETGKDGSIEETGRDGRIEGMGRDGKIEPIGRDGRIGGAGDDVEEVGRDGSIEESGRDGKIGGMERDGKTEGMGRDGKIEGMGREGNIEPIGRDGRIGGAGDDVEEVGRDGSIEESGRDGRIGGVEKDGKTDGIGRDGKIEGMGRDGKIEPIGRDGRIGGTGGDDVEEVGRGGSIEEHGRDGRIEAMGREGRIEGMGREGRMEGMGAGSRDVHPRPTFACRAETRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIC8</accession>
    <name>A0A2R6RIC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIC8"/>
    <dbReference type="STRING" id="98765.A0A2R6RIC8"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9200" checksum="8EF0ED1E0792F106" modified="2018-06-20" version="1">MIIAGTQRLASLSPALNNPDDALLPDFGDAPAINLEVAIAVAEQAIEEGNAGVDWKKEEVREKAIEKQWRPMYGTYVYDPNGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLL2</accession>
    <name>A0A2R6RLL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v2541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLL2"/>
    <dbReference type="STRING" id="98765.A0A2R6RLL2"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="245"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS30916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="454" mass="49609" checksum="10DD06195212BC17" modified="2018-06-20" version="1">MHKNCQRRKFHVGEIRNPLANSPSPTEIAPLLDEYAKHPPRPLTLSTLLSFGRPLTPESVLNSVGYVLSEVPRMFGWRVRALEELPFIVGMNPFIAKILAAHRRSFQLLATYPTVESLEDNVKFTTQLEALVQTHVNDIPIMAKGFQECSRYMTPEEISSFLDAAIRNRIAVRLLAEQHIALSRDLQDPDNRSKDHIGVVHMSCSPRDMIRMCGSFVSDLCEATLGASPEIIIDGQVDATFAYVPVHLEYILTEILKNAFRASVERHYKVHGSSSTHKIPPVRITIAPPPSPVPHPSVLSLRIRDEGGGVSPSNIPLIFSYSFTTAGPGNDEDELGGGPYAAQHVGGSAAIDHGPDGSGSSPGGSGNSPGLFGEIVGRGVQTGMGTIAGLGYGLPMSRLYAMYFGGSLDFLSLDGWDKGQPHRMRIFVSNLAYPFLDMLLEDIKSVPCGWEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLP3</accession>
    <name>A0A2R6RLP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLP3"/>
    <dbReference type="STRING" id="98765.A0A2R6RLP3"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS30929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52674" checksum="41962033F2B7C226" modified="2018-06-20" version="1">MYHPRDRHDTSPFLDNPPPSPWRARAKELSRRPLFTRQVAFVALFLVVAAPLWLLTHHGQDAIRASAAPEDLINFATSTERQIAPVEHVATSATPTISIPPSFNARPHGDVKAPHRQFFPPHMVDTPLEDQVTVVDADPVTFSFIMFSADSASEGAVLMKAFLEKRLALVKRPKHNVLVRFYKLTRADMTGRIEREGAIFTDHSAGVPGLMKLFIHEILPETVKKSIFIDTDAFFISDPLLLWQQFDKLGPNTAISMPTHPEQEAPHWHHANKICSCIMLLDLEKLRKLRLMDSSAYRNVDDGISPLSPAAFRAMFGPPGAEGHYEDVKLGDQGYWWAIVSHRPDVFEHLSFDWEVSSCLLDMYFTGLGHDDATEEEELAAQLHTWATPHQGQVILPKMLHLYFEWEGWSEPDNSLEKRWGAAMRYHVGLKWLWLNQANTNDTKITVETVGNVKFADELVASRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLS4</accession>
    <name>A0A2R6RLS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000229">
        <property type="protein sequence ID" value="PSS30981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLS4"/>
    <dbReference type="OrthoDB" id="3043660at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="149" mass="15936" checksum="0857E544B58F6774" modified="2018-06-20" version="1">MVALLSLVTLAATAFGLVSANPIEARQEALRFGVVNVNPTTVKVNEEFIVTYNSTLARYQPAFVDFYIQGTIVANGFVQPEYLLQRSSYPAGAKTLSFQTTLPAIEPDADKGYTDQAAYSVWAYITFPSPDTGALEVGGTSTGIGIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPH1</accession>
    <name>A0A2R6RPH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000215">
        <property type="protein sequence ID" value="PSS31917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPH1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="163" mass="17503" checksum="BFEC6DB2D49B0DF7" modified="2018-06-20" version="1">MSHSTASLDSVVSTSQADDSDRVLDLEQGTLDLQARASTLSDQLISTSDAHANAGPRRDPASTISPLPPLPIQYQSNRNGALPVLALPPTQTPSIVSTDDLSLTDPNTTPRRASADEQGHHPSDQDNRESSSLRSASLHSRTTRSSRTTLPAYSMRRLPSYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPV5</accession>
    <name>A0A2R6RPV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000202">
        <property type="protein sequence ID" value="PSS32046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPV5"/>
    <dbReference type="OrthoDB" id="2712987at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6862" checksum="96F5808AB50FC08A" modified="2018-06-20" version="1">MPGLVSDATRIWVIDVHWAMNAQCGVWDPKGKGVDIWECIRPPTKQPVLALCYPPMNSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZC9</accession>
    <name>A0A2R6RZC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000137">
        <property type="protein sequence ID" value="PSS35366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZC9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9352" checksum="31BAECF8C0F9FB1E" modified="2018-06-20" version="1">MAPLHAHRLYPECERSGRPLQITRRNRKIIPGDGILAVFVVGFKPLECKVTWRSTSVELTFPPEEVLSCGVESTLTYPIEADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3K9</accession>
    <name>A0A2R6S3K9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3K9"/>
    <dbReference type="STRING" id="98765.A0A2R6S3K9"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="741"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS36870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="806" mass="90207" checksum="241B330D313BDCA4" modified="2018-06-20" version="1">MPRENRKRGKKHKKPAEDFTPAPVHQEEELPETREGPSWIVSGPSTSEVNEEAPFGYVDSEVKAYFRTVDVQIREWQEEGHQVATEPDTDPNEGEFSFLSIIYCPSDGNHADRRLFFVAALDEMSGKEKELATDPDCSNILERMAYSMDDFARRVFMDRLTGSYKTLVKHRFASHVCQTFLEVASDTVARECRGILPPNPASSSEGELMLMKDIILDVCEELSPDFSSLIMDPFASHVLRAVLAVLSPHLFPLEQKSSALRSKKSAAYKARQGSMKSVFSEAQPTQPEAVKTTPPEFSPVAVKFVKVLRENLGANEVRALAASQVASPVLQMLLEIEADQGLAYEPNSLADRVLDGLITQLHESGPSSYEASDYVGTLLRDPTSSHLLETLVRCLPHEAFGPVWQIYLRGKLARLATHPVANFVVAKAFERVNEDELKQACEELNPVSEKIFKSSRTGVVRALIDRAAQLLVHEGDVIKMILEGFNLSQDDEERKLLVPCVLRLLTAEDYKKAKIAHGSQPEKQPEEAGRFRRNVRAERNEDPMAPKTQGAILLQSMLRLPQPHNQVVLDSISALTVDEQIAMAHDVTASRVLDAVLDSVSVPFKAKRKFVMDFIGQYHILVDDRIGSRVGDRCWAFADPFLKEKIGRSLIPHERTLVGSFYGKFFARNLNLYLLQRDPEQWKNFQSAAKAAAQAKAGQPQVAALASGSFAMSSQEKSKKRKARPEDEIDLLFEEKLGKKVKKAGLGPEPTPKPVEIKKEDKHGKEKKRRKKDDDDEVKDKGLEDVMGAIRLAPKDEKSHRKKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3Q8</accession>
    <name>A0A2R6S3Q8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3Q8"/>
    <dbReference type="STRING" id="98765.A0A2R6S3Q8"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="134"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="11">
        <location>
            <begin position="396"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS36902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1088" mass="121885" checksum="F58BD9895A591921" modified="2018-06-20" version="1">MDPDLNQLVQAIQIASDPTPSTLHSQALEYLQTIQQNSASTWRVALTLFVEPGPDGGRKYPPAARFFALRVIEEFLDNRLVAFFSGGMWVLRRLDYIRRFEPLDEESFQLLRQSLVSYIQSEYLYGSAEAGAAYLRNKFSHTLTLFFLVTYLDQWPTFFGDIFALIRPPQSTSQTTFNPHVSLLFFHLVHEISGEVADQLIKSARTYTAARQARDTRVRDAVRDRDAAAINEAVLTIVADGVERMSRLRKGDVASTNEKELDMAVEVVDWGTRTFASYVGWIDINLTVTPTTVPLLFNLLSDQSLTIRLATCGALTRIVSKGLKEPSDKLQLIKVLSLGQVLDTLETKTRAEHASRGSDVDEGEESYREALGKLLNVLGLELSKLVEECPIEDICNEGTQLLNQSLPVMLRFMADEYDDTCSTIFPFLQAVLGSYKKARKSSSEPLDESRRSFLISLLTVILQKLKWDEEADPEDMDDDDKVAFEDLRKDLRTFMDATFVIDQGLVSDALSTLALNTMNAYQRGVSVKWNDAELAVYIVYIYGEINKTGSKGRTAFCHTPVSVAKEKRKETDYSEYPLTKHGEMLYVLVQSGFSAYPNKTVAMQFFETTARYGDFFKVRKECIVPTLQAMMDARGLHNPESSLRSRVFYLFHRFIKEDRNEIPVDLAGSLIEGMRDLLVVQVEVPELDSPDQDLLTEAVKTPGIFDAQLYLFETVGTLISLFYKSPEQRGALLLSVVKPLLDDLSQDIQTVKSPEDVIPILKAHHVIMALGNIAKGFPEFPSPVPDGYILPPVDVFSQVAQAIIVSLEAMNSFRVIRDATRNAFTRILATTGPTVTHLIPPLMANLLAHFEPTELIDFMNFIGQLVHRLQEELYDVLDQLIGPLSAHINNLLSQPVTGTDDQVTHVDTKKAYLTLLNTIMSSKLHGIFTSERNGSQLEGLLGNMQRLAEDTSDPSSQKTAVQFLSRCVSIWAQPTMSNGDGQSQGLPGFERFVYERLVPSAFSVLSSPQFNIKDGQMLVVLNEICNFLQNISKARGEEAFNFFASAFLPAQNWPPDAALEFATKLRDLDSKAFKKYLADFVRASRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3S9</accession>
    <name>A0A2R6S3S9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000093">
        <property type="protein sequence ID" value="PSS36922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3S9"/>
    <dbReference type="STRING" id="98765.A0A2R6S3S9"/>
    <dbReference type="OrthoDB" id="4584900at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015333245" evidence="2">
        <location>
            <begin position="25"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="288" mass="30000" checksum="BF2D3A84A341F9F3" modified="2018-06-20" version="1">MAFGVRSLSLAAIVVSMVIGMVGAIPSASSRDVVSFNPVGIKLNPLDDLLAPLTARGMSNAQRLARGLPPNKPRFRRTDKQLGARTSPTPTTSVPSSSPTPACSPTTGALRAVSTDADMPLDGYVNASPNPYGEFGYTTDQVAAMIVTVSPCGNGSPINVVSSNSVKSMPYLGGIEGFADDSPDLEPREFNYMVLGGVTQTSPHATPQNGANSYTAATGNSKYIESAIWTIDDAGVLSAQWVNTNGSLPATILVYVPSADSFALIGDVDAFEETFYQAPISTFSVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3W2</accession>
    <name>A0A2R6S3W2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3W2"/>
    <dbReference type="STRING" id="98765.A0A2R6S3W2"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS36980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="193" mass="21128" checksum="F6DA6B807B3FEF9A" modified="2018-06-20" version="1">MLQSHRNRVFHDFRKGVCRNLVCSDLLTRGIDIQAVNVVINFDLPKNSETYLHRIGRSGRFGHLGLAINLVTYEDRFNLYRIEQELGTEIQPIPQHIDKGLYVAPGASNENSEPQQKTKQAQGKPQPSQSLQAQAPSQQRQSTPAQHPAGSAQVVYQSTAPQGRTNGIANAPQAQARAGFSQGAPRGGVPVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S489</accession>
    <name>A0A2R6S489_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1068</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S489"/>
    <dbReference type="STRING" id="98765.A0A2R6S489"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="240"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS37029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="320" mass="35572" checksum="CB5B2B14F0539286" modified="2018-06-20" version="1">MDIDPVRNPQESYTILRIKRKRTEEPLDALGNSVFIFSKYESCSSVELTVVESRPRRKKSKGGLNVFQFAETVEHSAWDDERQKQDLESRISTLARAKKEAQPNATPIPPPVAPPQEPEPVTQPSAASGLRSPVEDPSKKYTIVTSESAESNKSTRSRRPTAPPKIHSAKDLEKATFTMYDAVPSATSLASIVGSPSTEIDNEIEKFLPMLQDYLNINASESAVPASASASSIFTPQGENDYVWDVFYARPTSWRELYGLKNNVGTVTGLPDDDMYGSDTDSEGDDEDDEDSNDAFHEHSDYDDVVYEDRLTRMLEHAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4C1</accession>
    <name>A0A2R6S4C1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4C1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4C1"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="20007" checksum="7949AFE5F4426986" modified="2018-06-20" version="1">MTISPKFWDLGHKLFKSTQETFPVPSISGDVFDPTFLALAELPRNRTTKALAPLSALSTLTPLRGHLTAILASSFFHLFDEFSPEPGSIGIFGEHRARPEKGIRIEVAGMNTHSLMRLFCHCTESWKTLWERYVFGFEGKVKVEAFLEDIEREDFTAVEPEGTSKFYMMTWSVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4G4</accession>
    <name>A0A2R6S4G4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4G4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4G4"/>
    <dbReference type="OrthoDB" id="3245657at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="148" mass="15846" checksum="A69CCB5900A5FF75" modified="2018-06-20" version="1">MSKPGKSVVQTASLQYNGSAFYVYGILSESTSLPSSNANIVFLIDGQPIGKFVYTPPGIAGGYSFNVLLYGNDTIPQGQHTFTIQNGEVGGLGSLILLDYIIYSSLRQSQAHLPVPQIRQPQSPIPPPNLPKARPLHLTESAPKPAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5J8</accession>
    <name>A0A2R6S5J8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5J8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5384" checksum="7DF990F48998431A" modified="2018-06-20" version="1">MDISLSPIISMIPLSRADGSPTVVLQTIEKGTALTCWISAVACYNTDRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5W6</accession>
    <name>A0A2R6S5W6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGT1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5W6"/>
    <dbReference type="STRING" id="98765.A0A2R6S5W6"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="99"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21640" checksum="C8AC89FBB5A45B7A" modified="2018-06-20" version="1">MATIRHEFYETDEKVTISIFDKGADPEQVSVKFNPRSVVYQNGDKSLLLEPLKGQIDAEKSDYSVGKVKVEVRLVKMTFGRWGAIIGESPDLASAPSAQASRPKKTQKNWDGITTTILGSEKPVTSEQDPNVGGDSTVNEFFQKIFADADEDTKRAMMKSYMESGGTTLSTNWDEVGKSPVDVKPPEGSEWKKWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6E7</accession>
    <name>A0A2R6S6E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6E7"/>
    <dbReference type="STRING" id="98765.A0A2R6S6E7"/>
    <dbReference type="OrthoDB" id="2652381at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="334" mass="37246" checksum="36A8FCA607CBB797" modified="2018-06-20" version="1">MAIKVAGFYHLIGLQEKMEALKDDREDADRLLVAREKRRERTRDLAAIPAPRAPAIPEPSRRKPFQDFHPPPAIRRPGLDRATPAPAPVKPVVPNRFQVPEPPSFVDDSDDFQSSAADWSTEYSSQTQDGKRKRSVDRDVVPLVENNGVKRRAMEEMPDSRTPQTKSNPFARKPGADNNRNPFARGGETNKPVQKSESFFVKVDAAETEKTKRSSAAKGKGKERKETGRQTTLFGFSGAPLTAEKKGAGKKKLNEDSQTTATSSTEETQQETQDTDVTMDESQDRTQLDEEPSQVPTEIDEFASGQDLEVSISFRPISLGREELTWDSRVVQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U7L000</accession>
    <name>A0A1U7L000_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000586">
        <property type="protein sequence ID" value="PSR82439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U7L000"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6203" checksum="9A060D91256FE06D" modified="2017-05-10" version="1" fragment="single">MATKYNNTHVGAKTVDSVEETSEDIDELSEDQYGNVETPSEPIELSSDDGHPENDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE65</accession>
    <name>A0A2R6NE65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001337">
        <property type="protein sequence ID" value="PSR70653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE65"/>
    <dbReference type="STRING" id="98765.A0A2R6NE65"/>
    <dbReference type="OrthoDB" id="3187773at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="306" mass="34636" checksum="CBE458D69EC0B623" modified="2018-06-20" version="1">MEVLRQVHRELQVDQEDLDPDNNNEDSVEVPVSTAVGHSGAMEDSALGEQTEQVLLPPEDEGIPVDGKQVVGFVYMALTLQHGYPRTLLGLGQHMKYPSLVDHVWRFLYYQAHPNSDCSSTDLELWECPSIPNSQQVLVFHSACTTFYSPSDISGLGGMKSEHICSCPRWRGKKERRNCAFAQKDGSVPGIKGLFIVRVCFFFSFRIDGRRGTVYPCAFVEWFKLVGNERDPVTGMWMVEPDLDSDGIREVSVVHLDSLIRSAHLLAVFGDEFLPTDFHFLYTLDSFRVFYVNQFADHHANELLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEW7</accession>
    <name>A0A2R6NEW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001348">
        <property type="protein sequence ID" value="PSR70572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEW7"/>
    <dbReference type="STRING" id="98765.A0A2R6NEW7"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="281" mass="31162" checksum="5510AFE2E4C81434" modified="2018-06-20" version="1">MEGRAFRHGDIEDTLADLAKKVGGGFALGALLGKGTKFAGLDVKRVYFGNWLRDYSQAVDVAGLQKLPLQTIINLCMALGFLAHGYATNEFEVTEERLGVYLPTEHIDNPKGYPDDARKYNPKLRPPVDPRELEIDPRTGMKNYIANENGSWDTSKGLVRRTLEHCIHMGRQHRANGRKQDEYEAYRLLGQAASVTDLNSELEKARAKSGPMSRGGSPSDTLRNLFFNLPGGGGSEMAREMDSIERIRAEPMQGGKSPEQMSPQEIHAVLWQVLSFRDSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFW4</accession>
    <name>A0A2R6NFW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFW4"/>
    <dbReference type="STRING" id="98765.A0A2R6NFW4"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="13288" checksum="B94CFF0A8369E14B" modified="2018-06-20" version="1">MSQRAPNSLHNRTALLGTQEYYTPPSSGRSSPFGANNGQRFADDLEGQNDEHLEGLTAKIKLLKDVSGFRFRDPTLGRSPGSRLRLGSETRCESRQSNLVKWWVCLVLDSQKTVFISFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGB3</accession>
    <name>A0A2R6NGB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001287">
        <property type="protein sequence ID" value="PSR71359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGB3"/>
    <dbReference type="OrthoDB" id="2800010at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015302258" evidence="1">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="23980" checksum="535653F264CF2FE9" modified="2018-06-20" version="1">MPAITTLLSALPALHTIQILSCKIAGDFKNAVTYLSLPTVHTLIIPTDANALVRACPNVKHVRCAGGHGSALVGSLKGSECETLDGMIDWVKDRKVTERLVKSVPLLHTLEIRRPVNRGLGILSQNTAPAQWAQVIPSLAGLKQLRVLILTFPRRDEVPSDRASIDAARDVLRNSELGGEKKLIIRRIEAPHYENNPPHDPDKDLDLLLSESTEIFTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH29</accession>
    <name>A0A2R6NH29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001248">
        <property type="protein sequence ID" value="PSR71697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH29"/>
    <dbReference type="STRING" id="98765.A0A2R6NH29"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="389" mass="45419" checksum="032B0CB58643D909" modified="2018-06-20" version="1">MDSDSESDPRACHLPSCRQPESKKRCTGCHEVLYCDAKCQKADWPTHKLDCVITTAHHLTHAVYRDLLPQDQQTLSDYGFTKALTAENQSKLFGLYVGLIKFHDIKPHILHEWRIDGTLVRHIKEMYEAIPEGSRGGCYPWFLENQYVLDSSLKPPSPEDYIDTHQRRAWTFIGGSETDTGERIIAQVKTWPENKARCYELYGLLLARWHPSPEHDLWLPFGFCVTSEVSEMRLGGLYMDLIRKCTFEEFHTAFEESKLIALMDSKGFRQERLGFRDLESVLKTSPHRHFSVWTLKQLVYSEERGPGRTRFVFVDYGFMNCADEMERADLKRVYKEYFETWSLGEPLKLHEACIKGKIYEHVSGVVKRLKKDVNKYKRLMKNMYPLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHE7</accession>
    <name>A0A2R6NHE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHE7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="7548" checksum="1E7186A581C1E137" modified="2018-06-20" version="1">MRDTTSKAQGTCIHSVNDPSNTDISPLSALSRSGLAPPDCLYLTGTPTQKTSWLLVCDLADTLSETAHETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHK3</accession>
    <name>A0A2R6NHK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001245">
        <property type="protein sequence ID" value="PSR71728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHK3"/>
    <dbReference type="STRING" id="98765.A0A2R6NHK3"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="361"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="651" mass="74554" checksum="72A63ACB676150D1" modified="2018-06-20" version="1" fragment="single">ATSDPLYVGQMVARLLEWYKAWAPIPELGGTLSKSYTEAFRTHVFSILPPSFSAGFKALVAATFNLTQDPSASGWMLNLFPPPTQGPYSRADVPLWNAFEQLGMQERYETLISSVCYEYIESHILETCAKEWDRPMLYILREWMTNRIVPWMVLPYAKGARNAEEARTMLQGIGSRLDFHVCKTLATLRIQEIFDIIIDFPESQKALEDLKECLQRVDHRSQLVQSLRTANRRRLLHPGADTKTILMQYVSIIRCLRIVDPPGVLLFKVADPIRRYLRCAYTIDYCEAWLILRVRDRPDTIRCIVASLVGDGESGDSLVDENEPIQPLQQAQMDDYGDPNWEPEPIDAGPEFRANRPSDIISTLVSIYDSKELFVKELQVLLAQRLLAIKDGNFDRERRNIEILKIRFGEAALQVCEVMLRDMTDSKRTDQHIQSQEQFILHPTIISRHFWPPLQSSTFKMPGQFKQIQENYAKEYVKFKPDKKLVWMSHLGTINLEVELDDRTVTADVPPLEAAFIELFSTKDVWSTTELIKEVGSIDRSSAIRALTTWTELGVLKEDSADSFRLLKVAEEAGPSMPSSSRTDDAEQEPPVFIEGMLKNLGTLPLDRIQQMLKFAPGYNRNIEQLGTFMEAARREGLVTVKDGMWRLHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHP8</accession>
    <name>A0A2R6NHP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHP8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="169" mass="18519" checksum="E058EF3BBDEB7158" modified="2018-06-20" version="1">MVDGPSATESVVCCLGVHHIRTYVLQELGVKLLAQFLTLYDITVYTNTFLATLNSRNTVREIPNQCSSVSIPLSNIASDGSTVRSNNESGRVSRGHLGITRKTRYCTNGEVVDIVDLKPESTYTSENASDKVTDLPVAIRPVLLAPQSYVDRLLLPSPPALKDLYPERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ03</accession>
    <name>A0A2R6NJ03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001200">
        <property type="protein sequence ID" value="PSR72228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ03"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ03"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13678" checksum="8057D0804EFD60BD" modified="2018-06-20" version="1" fragment="single">YECPKKYREAWKTLLQQHLAAGQIRPSSSPHASPAFLIPKADRVVLPRWVNDYRKLNANTIPDVHPLPSIAEILSDCGKGQYFAKIDMTNSFFQTLVHPDDIPLTAVTTPFGLYEWTVIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJA9</accession>
    <name>A0A2R6NJA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11776</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJA9"/>
    <dbReference type="STRING" id="98765.A0A2R6NJA9"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2415" evidence="3">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="523" mass="57574" checksum="84F5D94BDB78FCE4" modified="2018-06-20" version="1">MSEASFAIHGRRQSWNTISLPPTPRHFWRSVVKKLNFICPSTPPLRHHIWAGKKGPNENLHDILGDSASISPDGRTLLSVGDSPDVYLHRITGGARITFTQTTKLSLAPYITTVSPYLYNLHPNGPVPASFSTAFSSNGSKFAVASQEGVVVVWDVRSTKPLKVIHTDKTRASSRAGNGGASGWLYENPWDWGRTGQGKAPGWGVRSVKFSPQGVGREVLTFTEHTSLLHIMDARTFEEEEIVRVPNFESPPTSRPPTARQRSNSPPSMRPSSSTTDLTQSLPPPPHIVLFSSVLEDTFRISSSDSTGRRRRHGRRMRSGDEPSGEEDGDGIVVIPALGDREVDEDVRRLFNGRRVLRARSNGVLESSITVGDINAGDERAEDDMDVDELESDCLSSYAPSRESSPIPSSGPLSQFQSQSQSQPQAPMPSSLPRLDSSRRTNLLARRESSGPYMSRRTSNHSLRRPRRGSPTDGSTDTEVEQDLAGTCFDPSGEYIYVAASRGISEWKVRGAEQSWWIDSSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJU9</accession>
    <name>A0A2R6NJU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001144">
        <property type="protein sequence ID" value="PSR72655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJU9"/>
    <dbReference type="OrthoDB" id="2804138at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015316725" description="EF-hand domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="456" mass="47952" checksum="6E471D9CB201CCAA" modified="2018-06-20" version="1">MRSSAVVALALLASAGPTISAPVSSYPFYARRAATSTPIASSSTDVSGAFSLEDAKNVASIGSSIVSAFHNIFGRDEFEQLLARAAVDESGAFSLEDAKNIASIGSSIVSAFHNIFGGSDNQSREFVEELLARADADQSDAISLGTISTIFSVGVPIVTGIIDHFKDSGNQQQSRELEALFARADIDETGALSFGDLKNIASIGGSAISIIHNLFSGSGDNQSREFMELLVRADADESGALKLPSLGTIGTIISLGVPVVSGIIDHFKNSGTQQQQQQARELETLFARATVGQSGALSLEDAKNIASIGSSIVSAIHNIFSREELEQILARADVDQSGAFSLEDAKNVASIGSSIVSAFHNLFGGNDSQRREFMEELVARADSDQSGALSLGTLSTIFSIGAPVISGIIDHFKNGGNQQRDFADPTYNAQMDFLRHFTGLTPSNSSPSTRSLNDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKT4</accession>
    <name>A0A2R6NKT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001152">
        <property type="protein sequence ID" value="PSR72602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKT4"/>
    <dbReference type="STRING" id="98765.A0A2R6NKT4"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="6">
        <location>
            <begin position="220"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="5">
        <location>
            <begin position="419"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="547" mass="60551" checksum="D34D6666FEDF01E8" modified="2018-06-20" version="1">MSLLSASSSSGSLSSRSSSPSFAGSASTTPSTPIHSTPTVFLITHPASAPFLKALPVCTGSGDRVLIFTGAGLAKPLLAQASQVLADASLLDSAKWESVKAVDDNENVVFWRTSSDISSFASPPHDSLLYLDKLSINTKEVSEASALNLFSNSNLRALISLPSSSSLTLHILERPPFSFPLLSQTPSTVLNPNANAYTIPSSSCFRDLWSAWDLVTLGMIPQSMLHQKPIDLRHKPLFYIGHLPTFNALLLTKLLRVPMVEPRNFGVIFERGIDPHVDDPDHCHSHSEVPEKDEDWPHLGQVLAFRDRVRALVMKTLGELEDGTRVLTRRIARTLVMMHEHEGFHIETLLYMLIQRAGTGTLPPPGFAAPAWAHLSTQWDTIPAPTTSSVTLGPCTLEMGHDDQEPQDLLSEFEGDVAGHEFGWDNESPKRSVVVGKFRVEWRPISNGEFLAFWKKMDGKVDMPASWVEEEREMKVRTLYGPVSMEYAQHWPCLTAYDDLLAYARSKGGRLPTESELRLFLDTYQVGHEEGSNTGFRNWHPLPAMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL29</accession>
    <name>A0A2R6NL29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001111">
        <property type="protein sequence ID" value="PSR73087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL29"/>
    <dbReference type="STRING" id="98765.A0A2R6NL29"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="293"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="475" mass="50508" checksum="A1F14D805F84B096" modified="2018-06-20" version="1" fragment="single">PSNFDFITLVVLHVMFPLYDFNVVCCALATVSAAVGYRYSRRNSQSHASWVRPSDIRSAKDLFFGRDGTVDSSCGSSTVSESDSSDVSVMDCPTPSAPPADVTEPGSLKRKNREYDGENLDSQLMGSSLEGASSPPRKRCRTPSADDTVVDEPTVLDVGTTGSDSVASPFNYSACETNEVLSQPDSMGQTPTAQAVVASPEPASLTPVHSSMPSAFTIPVCKPSSAFAAFIGVSTGFRTSETSTSGLSNPAWRSGSTITPVHDTPLEDTLQVSSGKTGSEPTQPTEAPATARAVTGVVPDPLAASEHTGSTHIVVTGEEDEEVKAELKGVKLFIKRGGKEFSSGMLGHVKLLSHNNTHEDRLVFRRELVLKVAMSATIRPAVRCTFDEEQGILRVALKETVKREDAVDPGVCQQVVVYALKVGSLSYSIRLLRFSPMPVQRGKSSREDFANFAKAVMGSPQLTAPPVVNAATSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLL2</accession>
    <name>A0A2R6NLL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001087">
        <property type="protein sequence ID" value="PSR73287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLL2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015325578" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8330" checksum="CC80FC647B068C87" modified="2018-06-20" version="1">MAYVVTLLTLSILSASNGRPVWKCSVRDANFASSKVAPSSQTSIMTAAEQLQMKVQEDPFAPSQPMGSNLSYKYAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLR1</accession>
    <name>A0A2R6NLR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001084">
        <property type="protein sequence ID" value="PSR73328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLR1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20302" checksum="0F158FA4A5A36DCA" modified="2018-06-20" version="1">MGIPPKAIQHHLTILSELPVSPVAQTYSGHTSPITPSTSETFMSVVPTNQVGGRGWAVGFVEFDTVENATRAKEDLSSHEVALGVRLNIKFAPRQIQPVDKGGFFGKDHGGDKFGFGVTSKERSPPRREPISTWYMQKHAEEKEKKGQRLEREQNKSLTRRLVALNARRRDSTPGPNFGFGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLX3</accession>
    <name>A0A2R6NLX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001085">
        <property type="protein sequence ID" value="PSR73321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLX3"/>
    <dbReference type="OrthoDB" id="3185381at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="213" mass="23944" checksum="D5BBF08AAE8377BF" modified="2018-06-20" version="1">MSYKPSSSGPKRQKLVLTTTSLRNVVVSNASDVIYYEIVTPKWARGNTTISRMDPNTRQFDIIAEMKNDDKGKAAEVRLYGGALKPAGEFLESNKENGKNASFTGKDGKRYTWKVQQKDLQLVREDLPEDQPVAVYHREKRYMNVLRMAKHPYLEVEPVALDTLDSLISTIFLEHSCIFSDNSTRSVFPPCGTTEAGWRSIISVISSSFAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM34</accession>
    <name>A0A2R6NM34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM34"/>
    <dbReference type="OrthoDB" id="3252109at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="33342" checksum="B7442EEEC8885D16" modified="2018-06-20" version="1">MTPGRKRPICHTCNTLMAGHKRPNGSPVCPIDTNKCVSPERDYSRTPSPAASPSPMPTPLRRENVIVIPRSAHYANPYYVEQQPTNLIPVYARPDRTGTPSTWVSTEPADDIPPVKPEPVLTGAAAHRREEREDDAFTSVSRAWSTTSSTGSSSTLRRGFSNILGNARPLVSLFSAPREDVQVITQAARRNGLFTGLIHRPDPPPEVKQEELSPRRNGAAQRGVQRDHSWWIILGQSAEAVGHLLDMQERDEMERVGGRRPDGTPNVGAYPVDVSAIKHSWLDSAFAGAVGGFIVFYLLAVMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NME8</accession>
    <name>A0A2R6NME8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NME8"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="3">
        <location>
            <begin position="806"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="4">
        <location>
            <begin position="1375"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1577" mass="176711" checksum="3189BB92B243CB65" modified="2018-06-20" version="1">MNGVRQQEDVAILPPQDDLDLSDLEGEESQDDHAGDYSTRLEELMSDEEHSDGQHETGEDEDEDAGFFYTGADAEPVGTYRDQLRDVLGPDHELEEQDEREVENSLVHDVEEKERFESSMDDEARPTDMLSDRSPTTSSASPSGYLTPPRIVVSSTTDVPFKKARPFLHPNISRLRSATPQASRSSSAGSVGTLYSQPDLSAPPSHFSALSPASTASNLPHARSEDARTNTDDDREVFRWTQLRNISDLTYRSPKQKASSVLGAPSVGSPTVLAANGLVCLGTNTGKILVFDFKQNLKCVCHSPDNVVGPVTALALSYDHTYVASGHASGHIQLFDINSPKTPARFVPPTTLAAVASGRQEGHLVGSRIVSIGFVAGRHTAIVSADDSGLAFYHSLGKVLFVEASDTLRILGKYPDEDPRDGIDYPSESALNTQHPFRRRRMRKANTILSMSPLPLGTTAHSTDSYQLIALLTPIKLVVVGLKPSPKTWYRCHRNVEDELPSKSRFKGVLAWFPSVVPGQQVPTEQVNGKNASARTNGTIPMLVYGWGDVLNLVRVSESKFSQNVRNPKTGKTTRVETGRIVFEEVGKWTVRGDMFALQWLNPNQVLVLTSTTLEVYDIRTFKLVEHVLFDAWSLMSPILAHTTNGSVSYPDAVTEVAHSVRVYKGKIFLLGQTEVLVGTLLTWADRILSFVEGGDFLSAIELTRSYYVGDAPGNRNGLPDGRDEMREVVGDKMHELMVASAHYAFSEERMTDETHITPDGRGVDRTSLFEGLVVTCARACIALNDFEFLFEDLYSHYDYHGIARIFLLQLEPFVLDGKIHYVPPRITQKLVALHDENNRPDLAERLIWHIDPDCLDINQAITLCQNYQLYDALIYIYTRAMRDYVSPVVELLGLIRRVQQYRRTRAEASPSSKQFVSEDTIEPVVLNAYKIYPYLSDVLTGLTYPSEEPIPEDEALQAKNDVYTFIFFGRSSVWPIGEGGKLVLTSDEENGVEPTYPYARLLLRYDAEAFLHTLDLAFEDHYLNDETHGVSRLVMVKILVEILSTPGLPQSDATFINIFIARNIPKYPQFIQMTPSALHSILIGLAEDEDENTREDRQLAAEFLLSAYTPHESDRILHLFERAGFYRILRRWHRQERQWSPLFMTYLEDPDLRSPEIFTSVDEILSTASRFNKGVLPPEVLTTVTNSLDSLLDIDVPSTAALVDKRISRLHEQVMQVLRGRTSHDRFVYLRYLIGSPRLFEDSEHLPYRDRTGPSPHIPAGMRLEYISLLGQSDPTAVIHELEYLPQDFLDWQEVVNSCEEHEIYDAVIWSLYWRGDDLNTALSKTEAFHELLSDNIARSLDTPEVERELELDKYLGSMRSIQNAAVSACVQYSNAASHGEASTEDMWLKLLKSQIGCVHRVSLFCSKRIAKESKSDPLVTAQAQAEEQTMVSLRSLVQDTFTSLMSASSSRAVSFPRLFKRLVDSVANSRTAKGMMYTEFRSILTTMLESYRSNGDMLVITKHLIDRDVYTSVEEMTRERMRGWAPSRGMCSMCGAILAEGSPSPDTSIIVSRTGAIYHRTCLSLDNQTNATNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMZ3</accession>
    <name>A0A2R6NMZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenylalanine ammonia-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMZ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NMZ3"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="80520" checksum="11ED29B2B55900EF" modified="2018-06-20" version="1">MPARVDYEYPVSSLPSRKTSAVLPAIGHVQHAHVQPLYIQPEQPTLFDKFVEAHEELEAYKGGRSVLVDGYSLSIPAVTAAARFGARVTLDASPETRERVLKSRRVIVDKVNAEKSVYGVSTGFGGSADTRTNDPLLLGHALLQHQQAGVLPSQTNRPLPALPLSDPLASTSMPEAWVRGAILIRMNSLIRGHSGVRWELIEKMGELLRENITPLVPLRGSISASGDLSPLSYIAGTLIGNPSIRVFDGPSVFGARQVVPSNRALAEHGVAPIPLSSKEHLGILNGTAFSASVASLALTEAVHLALLAQVCTAMGTEAMLGAKGSFDPFIHEVARPHPGQVQVAATILDMLSGSRLAMSEEEECHIEEDAGELRQDRYPLRTAAQFLGPQVEDILSALDVVTLECNCTTDNPLIDGETGRVHHGGNFQAMSVTNAMEKTRLALHHIGKLLFAQCTELINPAMNRGLPPNLSATDPSHNYFAKGVDIHTAAYVGELGYLANPVSTHVQSAEMHNQAVNSLALISARATINSLEVLSLLMSSYLFVLCQALDLRAMQFDLQAGVHKIVRDELTRHFGSNLSTTQLDALFPILSKAISSSLDATSKVDAAQRMNTVAASTTVPILDFCSGDPSSLPALAHISAFRADVAKQSTVLLGELRAEYLEGRKGPAPASMYLGRTKSIYEFVRLTLGIRMHGAENLHNFREGPGIEDLSAGQHISLIYEAIRDGKMQDIVVHLVRPTAASNDSTDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNC3</accession>
    <name>A0A2R6NNC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNC3"/>
    <dbReference type="OrthoDB" id="2802908at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26265" checksum="7BCE9A62E05FC7E7" modified="2018-06-20" version="1">MSLIVASSNLFADLDGRILVSIASLAAYFVYHRYEPAGVLPALGFLVAVPGLLSASLRGISSTILGTIVVIFPLYWSLLVLVTVAYRISPFHPLARYPGPLLCKISKGWIAYLVARYGKAHIYVQELHEKYGEVVRIGPNELSISHKDMSTAVLGAKGLPRGPYYDTREHEAGVSLDGLRDPALHTIRRKPWARGMNSTAMKYYEDLVRSQVGELARAFHQREGEKVDISAWMTFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNG3</accession>
    <name>A0A2R6NNG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gag-pol polyprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001047">
        <property type="protein sequence ID" value="PSR73941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNG3"/>
    <dbReference type="OrthoDB" id="2802317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37610">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37610:SF83">
        <property type="entry name" value="RETROTRANSPOSON COPIA-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15924" checksum="DD952EA55BE591AF" modified="2018-06-20" version="1">MSTSTSTIPDFKAFSRLFDISSLENNGSNYSTWKFRVKTILKIRSLMPIVNGTEACPSPSKDDPKTKEITSWNTRDHKAKAQITLTLRDELLNGVMYAKTSKEVWDRLKDWYEGKGKQTIAYLITELFRGTLDDKSPLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPA8</accession>
    <name>A0A2R6NPA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001006">
        <property type="protein sequence ID" value="PSR74284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPA8"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="303" mass="33151" checksum="84F9C3BABDF11734" modified="2018-06-20" version="1">MLSRNLSSSSLQDYDLQNSHDDPAETDGMRVTLRKNNAIQGAGGGGILSLSSIILSDLVALKERGLYNGMIGLYVLIYWPFRFDLILLWIEHGPVRLPLVRSLEGHSLKQANGDGYSVWGVTIGATVLQTQLSRRLPPAFLAQFPGGVAISYSAIPVISSLLEPAQSEVREAFAQSIIVIWQVMIGISCIGLLSCFGMKALPLHTEVDGKWGLHTEQINAIPSEPLDPTGSESKRSPTPPQIPELPRFADFGWFIIPEGTDNREAAVCLCGCQGQNHFEVRFVDGTANPLVLPAFWVQVRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQK5</accession>
    <name>A0A2R6NQK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQK5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="7360" checksum="9C46ED34B6240FCD" modified="2018-06-20" version="1">MENITGYEGSIVICNAHIPSDNLEDGSKLYDLTCINGIITSIGEAGCSSDPSDTPVPAVHKMDVGGGLVLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR06</accession>
    <name>A0A2R6NR06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-mannosidase-like galactose-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR06"/>
    <dbReference type="STRING" id="98765.A0A2R6NR06"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="171" mass="19576" checksum="5B5F21F2293316B3" modified="2018-06-20" version="1">MPELRTKDINNGWSFTQIGGGEAIKDGEWLSVKQFPTTVHVELLKYGKIPDPFVGLNEWDVQWVGEAEWSFKTEFSVNEQELAAPNAYLVFDGLDTFATVYLNGQKILETDNQFLSHRIAVKNQLKPSGNELLINFASAFREGRKVEKAHEKLYLWNGDSSRLHVRKAQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRI0</accession>
    <name>A0A2R6NRI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v9205</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRI0"/>
    <dbReference type="STRING" id="98765.A0A2R6NRI0"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="12">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="255"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="287"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR75342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="405" mass="44313" checksum="6A8C69F08C2FDCB4" modified="2018-06-20" version="1">MGPEKVKTTFAFHLLPSGLVNPKCTGLIGNGVVVHIPSFFAELDALQSQGLDCTGRLFISDRAHLVFDFHQIVDGLKEVELGGSSIGTTKKGIGPAYSAKASRSGLRVHHLFDHETFAAKFRKIVEGRFKRYGHFEYDTEGEIVRYKVLAERLRPYVVDSVVYIHKALGEGKKVLVEGANALMLDIDFGTYPFVTSSATAIGGVSTGLGIPPKMVGTTIGVIKAYTTRVGGGPFPTEQLNDVGVHLQEVGREYGTTTGRRRRCGWLDLVVMKHSCLINGYDTLNLTKLDILDDLKEIKIAVKYMLNEEELPGFPGEPTLYGCPTNADSTLGLADLGVLDKVEVVYVTLPGWQSSIASTTSFGDLPENCQKYIGFIERFLNVPIEWIGVGPGRESMIKKERKIAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRX9</accession>
    <name>A0A2R6NRX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRX9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10192" checksum="3949D308C9BDE794" modified="2018-06-20" version="1">MGPRTSPTATRAGTLMYRGAIAEASTTNAVSIGHKNVKPVLKDLIMQQAGGYPHRHPFPTATARPGYMQLVEVHLGNQWVRGRIEQARVSSILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS70</accession>
    <name>A0A2R6NS70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS70"/>
    <dbReference type="STRING" id="98765.A0A2R6NS70"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8048" checksum="7A2BFB497C156D4F" modified="2018-06-20" version="1">MSMFATPAIPATKLGRHRQLSPLAGVHVSPIQLGAMSIGDKWQQHGMGAMDKDSSFKLLDAFYEAGGNFIDTANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSQ3</accession>
    <name>A0A2R6NSQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000871">
        <property type="protein sequence ID" value="PSR75953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSQ3"/>
    <dbReference type="OrthoDB" id="2802668at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="12463" checksum="D48089745C13BBA4" modified="2018-06-20" version="1">MSRQSTVVPPELLYEIVGLILAEYLDDVIAGFHRLPGPTPMDLLTTGLLTDTELQELQEPLLSPPIDQNTEDPALSFPSPIVPLLRVSFQLREVTLKVMSDALGIAIDNEGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTJ2</accession>
    <name>A0A2R6NTJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000868">
        <property type="protein sequence ID" value="PSR76001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTJ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NTJ2"/>
    <dbReference type="OrthoDB" id="3227959at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="365" mass="40814" checksum="851BF4C15D1D433A" modified="2018-06-20" version="1">MSTPPTGNTTRASNDHGPDNVFHSYPRHSDLWFSDGSVVLLAERMLFRVHISQLSRHSAFFRDMFLLPQPSRSTFSSSVISEDLLDGLPVVQLHDAAEDVSSLLVALYDGPSFGNNDRDDFRVVSGILRLSTKYVIDLLRAKALAHLSTAWPASLKAWDAREEISRMYESETTMPRGLRYPPPIEVVNLAREINAPNLLPSAFYDLSRYHFSQIFDSGQEDAIHGSSLAATLAPSDLQCLALGKEASLNMIITLIQSMGAHYQREHIAHPAGSVGSRHRRSYGLICHSGAACRQDFAELVELATQHYLVDREKGCTDPLYVAEELGQLKSAEVSECKACARSLETWASKEREKIWKLIPQWFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU33</accession>
    <name>A0A2R6NU33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU33"/>
    <dbReference type="STRING" id="98765.A0A2R6NU33"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="214" mass="25177" checksum="B1B81A4493BD7528" modified="2018-06-20" version="1">MHKAWPELLKRMRANKVSTSTKERQLVISARTWFCLYLFEHQMSYGTGRPAILKDDESIWQCRLLLQHPLAIEDDMRLVSTVELMAIRERVHNNLSPLFEKPVDDHTFNVLREADLEFRNWFATWDQAFSQKYEDAAFYRQSLQIQHLTAELFHNATALRGIDGPEDVQRMPHAQRELAIKSINIGRQILDITVNSPAYREGMKYGLYYSFDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU87</accession>
    <name>A0A2R6NU87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU87"/>
    <dbReference type="STRING" id="98765.A0A2R6NU87"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08228">
        <property type="entry name" value="RNase_P_pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="320" mass="35850" checksum="93793F27403128C2" modified="2018-06-20" version="1">MAERIAQTHRNKSNRAKLQDSIDRKTVYRSVLDTPFRIPWPSVPMNVQNAFLARVLSQLDGVFDYQMYRQRKRRREKSLVFRARKKQKPSSDSPVNINPSEVVNCEENSEQPQDDALDPPPLLHHLTIGINEVTKSLEDLVKLSRHTVSSSQTSDTQVNIEASSHIVLVCQADIDPPILAGHLPHLIASCNTVHRHPGSATSQKTVWLVPLPKGAEASLAEALGLRRVAVMAIKSSAPDFSAFQSLLESVPVLRASWLTKPDFAEQPMLLPTHIKQLCTTAPKDMKAEKERRAQGRAASKQRRKERHVNGKIPKRLSVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVE8</accession>
    <name>A0A2R6NVE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v7748</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVE8"/>
    <dbReference type="STRING" id="98765.A0A2R6NVE8"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="237"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="574"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR77558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="812" mass="91700" checksum="3198C9EDD56161A0" modified="2018-06-20" version="1">MLRQTQATARLQGSSVINQPFKPPTPIVQREQPQRKRKRVSYKGAQAENDDSDSENDSGGKAKKKKKTGKNGDYESPRDNNIQHYPVFTPKPFEEMTKKFAIPGIKNSDGEYVHKPSSNIALGIRPVVNIIPRPLHDPMQDHAIVLYDPTIDDRETDEERKEREKEEEKARAAKEAETKNAGLYNPHGKTLKELLGGGTDGKKKANKVAVVIDPRLTKVLRPHQVEGVKFLYKCTTGMVVENQYGCIMADEMGLGKTLQCIALLWTLVKQSPRAGRPTIEKCIIACPSSLVKNWANELVKWLGKDAITALAIDGKGGKAEMLERVARWVAAGGRNVSQPVMIVSYETLRTLSVHLTNCTIGLLLCDEGHRLKNSESQTFQALNGLNVKRRVILSGTPIQNDLSEYFSLLNFANPNFLGTKNDFRKNFENFIIRGRDADATDAAKAKSEEKLKELGGLVAKFIIRRTNDLLSKYLPVKYEQVVFCHLSDFQLSLYRLFIKSPEIQALLRGTNSQPLKAINILKKLCNHPELLDLPGDLRGSEDLIPEGFCGAGAGARTTGRNQEVHTEWGGKFLVLERFLHRMRTETNDKIVLISNYTQTLDLFEKLLRNKKYGYFRLDGSMTINKRQKLVDQFNDPNGKEFVFLLSSKAGGCGINLIGANRLILFDPDWNPAADQQALARVWRDGQKKECFVYRFITTGTIEEKIFQRQANKQALSSAVVDEKEDAERHFSLDALRKLFLFNENTLCETHETFKCKRCKDGRQFIKSPALLYGDASTWNHFTNEELKNNHDDLLRAEVGLPEVSFVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVG8</accession>
    <name>A0A2R6NVG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mif2/CENP-C cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVG8"/>
    <dbReference type="STRING" id="98765.A0A2R6NVG8"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="6">
        <location>
            <begin position="480"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR77577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="547" mass="62145" checksum="F3E12B0A9BEFB3C0" modified="2018-06-20" version="1">MPVSARKSSLGATRRGPQKYIPYRADDLQHGKRTGIAVGYVDHNSDEFEPFDKVMSQADLRTPPKIKVHNKKKRPPKTPIIEDDEDGEMSMELEESNPNSPAAYFASARVGSITSSVQRIGSSSRPVLNHSDVDFDKVPSPRPRSSSSFARHSMANGRSSGPSHLSRSAVAENMDSDSEPDFGRNDYAGDFDGGFDTQGPPSDESDHERTPVPRRKQSISSRRPSFAQMSQDHEEEPELEADVEEEAVQEYRSANVRSAKGKQRAMEEPEEEDMEDDIAQGLAEVELQEDDDVEQEEELPRGKSRRRELDDSGEKEQRPNKKARTENDEATKPKKPRGRPRKENILREVVQDNNIDDGNVRRGQRMRYKPLEWWRLEKVVYGRRENGQCLVPNIKEIRRVPKEEVQPLGAKHRRKRQTRSKSQSVTEPEIPMIYNPEEGWDMDTKAEGVVVDYETKQEVTRRVAFTSKMVRTRPAANADFFFQKIFGDKDFMAAGMLSIPPNGEKPTKGTKDNTFIFYLVEGAVNFKVHRTSYVLTSGSMFMIPRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVM1</accession>
    <name>A0A2R6NVM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVM1"/>
    <dbReference type="STRING" id="98765.A0A2R6NVM1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="416"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1195" mass="136153" checksum="2D85281DDBD0145E" modified="2018-06-20" version="1">MELDLKGVPFQATNWDVKRSIGAILHSDEFFDTSEPKARLINFKVTLNRSQGVQNDGSGLLILPSRTVAQKLLKYVYGQGKAILVKDRKIHFQKSGRKPDPRTTETLEKTPYLDPEIEEEREAKLEKLDVGLHVDKLQIGVFYRMPEDPPNASRLFSNEFEFSHRHKGAGLLHIEYDHKLIRIQLGDPVTEELAYNVVITFANIRKLAIGYDFGNPFACFELWTPPVFQLERFNRELTGRDWNDSRKYRQRLESINASHGAIAPYAHQLRIILHETKDLEDFSYLCTVAGLPRPIKAHMEAFSNGFYAARKLHNLYLHFKEFDWRVAFQMEAMLRNGLINTQELLQQLYQPIKDLCSHQPATAADTLRLFTDALRSPDPRQSKIDRFRQICGRDPSESLSAHRLSKGNFLCHHVTITPTRMLLEGPFVIQSNRVIRKYQGYEEHFIRVDFRDEDRLQYRWERDTDGTSLLQTRVGGILKNGFQLGGRQFEFLAYSSSALRQHAVWFVHPFQHHDLGFLDAEKIRMRLGDFSGVITKPSKYAARMAQAFTATDPSVRISRDQWEEVEDLGAEPYLFTDGVGTISSQLGDMIWEALCADRGESYKQRNIKPSATLSPGYKGMVAVDDQLEGIRMRLRESMNKFEGPKDDFAEIEIARAFERPGTCYLNRPLIMVLEDREVDKKVFLDLQEKAVAKIHMASDSLMQSRRILRENSLGTAYGLPFVLQFLEAIGMGMEYEKTQYKLRDPFLDRLVHFAKNHVLRSLKHAARIPVHGSYLLVGVADEGPAYEAAGHQNVFRLEDGEVFACIQQEPDDEPQYIEGAVVICRSPVVHPGDVQRVRAIGKPPDGGLCLFRNLKNVVVLPSVGQRSLASCLGGGDLDGDLYSVITDSALLPTRHVDPADYTPVGTRDLERESTIEDICDFVVEYINSDVLEGTLDPECLTLAQLCSQAVDYPKNGIPVDIYNSPRWLIPYKPDWKKSEETSPRSTDYYESARALGELFRNVRLLEKDQMPSYDTNGNNSRPRPLSDNISQALKSYITDVLGQSGFYNKDADVAAMAPLFRGYVEELKYICLTHSLFDSPDSRLVEEEVVIGTILANCSQNRHRTDRMYRLRLNASVLVWDIRRRIYERTKTPTAGELRYGLTQAWLAWDFGKRNKGIFGANSFTFIALAVIADILDTMGAVDVKRAGKRSNDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVM3</accession>
    <name>A0A2R6NVM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v7827</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVM3"/>
    <dbReference type="STRING" id="98765.A0A2R6NVM3"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="68"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="13">
        <location>
            <begin position="259"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR77637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="353" mass="37757" checksum="FA41FE67CD0718A6" modified="2018-06-20" version="1">MSRTFKVRVPSTSANIGPGFDVVGLSLSLYLTLTVTITPPSSSSPPSPPAITYSGEGSDEVPLDAYKNLTTRVALYVLRCNGISQFPANLTIHADNEIPFGRGLGSSGAAVIAGVLLGNELGQLNLPLGRMLDFALMVERHPDNVTAALVGGFVGSYLRELDSVATEAASVPLSEVLPEYPPDAGEEWGLNPPQPPFGIGHYVRFGWAKSIKAVAIIPRFELSTAKAREVLPLEYSRKDLVFNLQRLAVLTTALAQEPPDPELIYEAMKDRIHQPYRKALIPGLPEVTSRITPASHPGLLGICLSGAGPTILALATTGFEAIAEDARKIFREKGIEVDWKLLEIAGGSVVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWF0</accession>
    <name>A0A2R6NWF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWF0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="257" mass="29055" checksum="40C621B78DE13AEE" modified="2018-06-20" version="1">MSRFISHTLTITDRQAASIYSKSLLESTSQHSHPIPLATIFNEFIARSPDLAKVIKDLNMLHTSEYVLGQRERICDIRDLAKVVDLFDLLRSLMLCGLAIKVPQSYKTESRGRTIDKLVFQLPPYCFGSTQSFFAPLLLFERVRAVKFCANKPVSMPVDAQRKSEGSDFVPFPPETLTISCTHQSTGSVLDVLIATKPWHAGVAIKTLRIKELTSPSIPSLRRFLDHFGREVVHLKLDFRFGCASSPFNWCHLMRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWH9</accession>
    <name>A0A2R6NWH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWH9"/>
    <dbReference type="STRING" id="98765.A0A2R6NWH9"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="150" mass="15562" checksum="DF4C28B7D8A4B141" modified="2018-06-20" version="1">MSASGTILGRILPGILGNRIGIFNLIIIYTALGGAVIFTMSKATETSGLIAFAAVYGPCGGVLQSLFPALVASYNDGVTASEYGLRLGFGFLVYGIGCLVGGPINGALLNPPSYDWEASIVFSGVMIWAGCVALIASRRILAVRKGSWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX43</accession>
    <name>A0A2R6NX43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX43"/>
    <dbReference type="STRING" id="98765.A0A2R6NX43"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10528" checksum="3CE71872F4840B8E" modified="2018-06-20" version="1">MTLPSPSAPTHLLRYHLAAVNALHLSEDNERLCSGDASGTVIVTSTRSLRPLARWKAHEEGLLGVEEWEDMVETTNYTSGNSHRSLRRKSETQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX75</accession>
    <name>A0A2R6NX75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX75"/>
    <dbReference type="STRING" id="98765.A0A2R6NX75"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30640" checksum="C0040B315D591749" modified="2018-06-20" version="1">MRSAFSEVGNYDRVVIQELLKEIAQTQQVDINARHRFKVVIINEADSLTRDAQAALRRTMEKYMSNMRIILCANSTSKLIAPIKSRCLLVRVAAPTEDEMMRVLHHVADRQGFKIPNDEEAVRAIAKDSNGNLRKALLVFEALKMQTGSLSGPIAIAKPDWETYCQKVGDMIIQEQSPARVMEVRTKLYELLSHCIPPTVILKTIADRVVEKVDEHLKADIMHWAAIYLSAIHAVWCACIRHFINGRRILLSDITSVSIRCANIHELDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXC3</accession>
    <name>A0A2R6NXC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v7240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXC3"/>
    <dbReference type="STRING" id="98765.A0A2R6NXC3"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="208"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR79053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="295" mass="31553" checksum="60FB47B82688CE99" modified="2018-06-20" version="1">MPFKLPGMHDVDDSHEMHAPGIQNTGDPVVDSSQHSTRPQTRKKSTLADIARTLSMQLHPQRPVAEAPGFLQGVKAIIFGSYLNVLLVCIPVSLFSHKGLYEDSNDEIMKSKKYVNVKMPFKKHSRQSILGTVNSAEPEIIVSGDMVASTSTHLNGGAMNIHDNTSSESHMATNASEAEAGRALLHREEHQEEVEEVEIPTMSLSMTIGLLAVVTVLVAVTAEWLVSSIDGLTASGHITKEFVGIILLPIVGNAAEHVTAVTVSVKDKLTLSLGVAVGSSIVCPSNPIITILATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYP8</accession>
    <name>A0A2R6NYP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000653">
        <property type="protein sequence ID" value="PSR80471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYP8"/>
    <dbReference type="OrthoDB" id="5176693at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="186" mass="20617" checksum="9AF67F5D66E6C18B" modified="2018-06-20" version="1">MTRIDMLISEQQNLKDADGDHVWEARWYKIMLSDGTELGFGQQVNGKLSCGPCPAGQGMAFRYIRSQSDLTADNHGWPAGEVGYLRGLGMGTDGREYRKHLSLSDGAPPALLWYDTANSYGFSGEPLPGNKIALYAHDQYSRKVGLRGHVIHEEAGFYGQRSDFPICLDCSFVRIPVGDEHIGPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ55</accession>
    <name>A0A2R6NZ55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thymidylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ55"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ55"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Thymidylate kinase-like" evidence="2">
        <location>
            <begin position="81"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR80369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="188" mass="21038" checksum="A239DC36DE3F6BAC" modified="2018-06-20" version="1">MTKRGAFIVFEGLDRSGKSTQAATLLKRLQDAQSPAKLINFPDRTTAIGKMIDSYLRSESELDDHAVHLLFSANRWELAAPDVGLPAPDVTIFLDVTQEVARARGGYGEERYEKEGVQRRVRDVFERIAEEVEGSGGRWVLVDADESEEEVQKVVWDTVKDIVGGIEGPIEKLWDDKREAGNVDALYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ63</accession>
    <name>A0A2R6NZ63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase WRNIP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v6464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ63"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ63"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA C-terminal" evidence="5">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MgsA AAA+ ATPase C-terminal" evidence="4">
        <location>
            <begin position="366"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR81129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="59550" checksum="B96F750774543322" modified="2018-06-20" version="1">MSSNVVRIEYSRSITTRPDINPHSPVCSRDVLESRINDHLDNDCSDTTPSTSKVQLNSTPEQRKDSKQLAPIFGSANKQHVARTASLQTATQKRRITEDNASPIPGPSKRSKTTKSKFASAAPLAERLRPQTLEEFIGQPQLTGPDSLLLSLIHKGSTGSMIFWGPPGYMRLLLLTGDDTDVVGWCPCRCGKTTLARLLAKSTDAAFKELSATDSGISDVRAVGEEAKGGPFSSSTRCTDSTKPSNVFVLNRLTDDDITRIVKQAVKRASPSETLSQSSDSTAVDAPDDINTFPQLTPKLLSTIVSLSAGDARTALSLLELVLSAAADADPDNLLISLRQSVSTSYDRTGDSRYDMISALHKSVRGSQGSAAMYWLARMLTAGEDPVYIARRMVVCASEDVGLADNHALPLAMAALQACQLIGMPECRINLAHLVAYLSEAPKSTRSYEAYKRAEEAAKLDLTLPVPPMVRNAPTSLMKELGYSDGYAYNPDYLHPVTNDYLPTQFETDVFLRPCGDTTGKVWDEDALQRWEIKENNSEKWEGRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P022</accession>
    <name>A0A2R6P022_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000606">
        <property type="protein sequence ID" value="PSR81819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P022"/>
    <dbReference type="STRING" id="98765.A0A2R6P022"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015319680" evidence="2">
        <location>
            <begin position="20"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="521" mass="58878" checksum="300F0B4AA955CF75" modified="2018-06-20" version="1">MLSFWQWAIFLGLITFGSGVHCIGQQTCVAFQSSSSTFPIVTKGQGTPVFLSADEWPGVQRAATDFVSDIQQVTGVKSSLSNVTVTGSTVSKKASSVIIVGTLGKSSLVDQVVSHAKLDVSSVEGQWEAFFAKQVKNPLPGIDSAYVIIGADKRGTIYGLYDHSEQFGVSPWYWWADVPTTKHSELHVTASGCSHGSPSVKYRGIFLNDEQPSLQNWAMEKFTNGTGAPLTGSPFNHFFYTKLCVHVVRFKQNAIITTYFVYRFELLLRMKANYLWPAIWSSAFDIDDPENQPLGDWWGIVMGTSHQEPMMRGTPIEWDLFGSGPWDYGVNAQNIYNYWVYGAERAKPYESIFTMGMRDKEVEGYYDDGMRVPDDITLLWTDDNFGNIRRFPVISERNRTGGAGVYYHVGDPRDFKWITTFEQMSLAIDRNADRIWIVNVGDLKPYEMDTEFFIAYGWDASIWTPENLNSFVTSWAQREFDLPSQQSLQVSNIIAGLTRFNARRKPELLNSTTYSLTNYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0A0</accession>
    <name>A0A2R6P0A0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v6148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000600">
        <property type="protein sequence ID" value="PSR82078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0A0"/>
    <dbReference type="STRING" id="98765.A0A2R6P0A0"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000044">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="314"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR82078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="55966" checksum="F82D992EF154F87A" modified="2018-06-20" version="1">MESLAVGNESPPARQSILGSFLRGRPRGVSQSHPSPDVPLPVRDSPPPSAAQDLPGHRRRPAAVQPSLSQSLQPSSSVAATNAGPFSQMLRRRRSAGALAPNAPPQIPTSIAVARTAVASNTAPASAVSGPGHRIRLVPHLDSRRSLRFDPICRDVREGEPPLRIGRFTDRSGLGLAAANALGSNKLAFKSKVVSRAHAEIWAEAGGKFFIKDTKSSSGTFLNHVRLSPANTESRPSELRDGDLLQLGVDYQGGTEDIYKCVKIRIEVGREWQAHSNPFNSNALKQLKAIAVQPTAAASGKKVSASAKSALPDCCICLFCVTIRQALFIAPCSHAFHYKCIRPLLDSHHPAFNCPLCRTYANLEEDVEVDIEPDEESIAEASAVIAGVTPVIPEHSRERDAGAETEVEQDTGNQRLGPSLRRRPVPPLPNGTEIVDLTEDADEEMEDANPLPALPEDSDDGEPELEARGRDMSVSPVPHPARTNRSAEYLFEADGEGSGSAEADAGASDGSGNMEGVINGKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0F0</accession>
    <name>A0A2R6P0F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000594">
        <property type="protein sequence ID" value="PSR82258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0F0"/>
    <dbReference type="STRING" id="98765.A0A2R6P0F0"/>
    <dbReference type="OrthoDB" id="2754413at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="401" mass="43699" checksum="03C9ECA94C77AD27" modified="2018-06-20" version="1">MNIPATSDDDVSELGDDDDSDIEQQDEPDQVTEVALLEKLLKQDASAGLQSTATDDCMFSLSCAAVALSLDEMNQVQSYNAPSEQDSLAEQRIDADTLQVILQVSATFDLPPLETLAAERIRPFDRAMNYSKNMDYSMLVSVCRHHQTERAAAAVCVRLHSDVVPLDPSKSDSDLEVTETPSARGKIISEMYAVLRKAEQGLGVGTGLERQARISGSTVVQLTGNTANAALAAGQRATTVVNRRYKVFSKHHIPQSKELGDALIGISHSSQPNHQLLKPGRNGAKNGTHAWVADTKNIGLVSYLVMQVYEPAFLTKFRAVHQRVAALQTYSFLHVSSDHFLRTLPGTQTLSTDGRTMELNQDAYAVFQGLDTTRAKSAINAAVKLLDQARRKGNKGTTNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0F9</accession>
    <name>A0A2R6P0F9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000589">
        <property type="protein sequence ID" value="PSR82347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0F9"/>
    <dbReference type="STRING" id="98765.A0A2R6P0F9"/>
    <dbReference type="OrthoDB" id="2781456at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015338994" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="51110" checksum="88F8AA1E8399C57F" modified="2018-06-20" version="1">MKSVLSLFAASAAVASAASTNPVCIVGAGPTGLTIANGLENKGHSTVIFEKNSEAGGKCQSYYDPSGQFHPMGALLFSNATFTETLKVVLQTNMTYYPFGYAGTAQDWLFDWRTGVVTLAPGSSAQLYPFIKADIDRYIAFWNQNIQPIWADIGYKTSIPHEYTVPFAQWLLKNNYKAELVGLFETGMVPYGYGDVNETPAIYMFKYFTPDILLFFAGQHLGYLVDYNQVFLKYSQSSVKGKLHVSTNITKIDRSGNYPIITYTDTTTRSVTQKCSKIVLAFPPVMHALEAAHLDLSPEESAVFSPIGTTQYWSGAVNVATGNNAAFSAIAFEPAGQPSAFLPLFNSSSIASSWSWGQYRGSQTVDEAKQLLVSTISKFNKDPNNATALPRPITPEDVRDFKAWDYFPHYDTAQLNEGFYSKFNMLQGQKNTYYASGLNGFEMVEFAIRAGQDIVNTYFPKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0U4</accession>
    <name>A0A2R6P0U4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000577">
        <property type="protein sequence ID" value="PSR82741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0U4"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34829" checksum="7E2827143179A19F" modified="2018-06-20" version="1">MPKELIDMVLDCVGRDVPSLKSCSLVSREWLDPARRRLFQTFQVMSGRNTRSFDAFLVFLNYAQGICASVQELHLTGFDTHSHSGVISHYLFRTILDQLPSLQTLSITRCYWSPSTGYSGHALKFLRKLSIRTLFLFDFIHFVDILSLFSSIEELDVCDIKWTDSLALSTPAETPPHDIKQYVTRLSPGFRVGELSIENTENFMAFLWCLKELPFMQSLTTLNIRKLFPDPLDTHPEGVKYFAELLRDTGPTLLNCKIRLPQMYGYWEISELPFMCRSFRVLPAYHLDARIVRKIRRPLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P159</accession>
    <name>A0A2R6P159_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P159"/>
    <dbReference type="STRING" id="98765.A0A2R6P159"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042453">
        <property type="entry name" value="WDR53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44666:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="32909" checksum="7610693FC683A2C8" modified="2018-06-20" version="1">MQIALNCYSSYTRIQASLFEIGESKLIFTSQDALLHLELGEDQDDVLNELSVSDNKKIMAFSTDGGTVGVVDLVDYKVIRMKTRHSSICASVKFVPDRSSELVSGGYDSALLHFDFKQGSLLSRHDIAAAPPSSGVSLSPPFVLSISISPVGLIAATTADGRLWIGTGGDKTISLGGKKKKSRKWEGLRESEGQFVQIADGPVVASTFVSESSLLTCTLLGNIAQHNITYNEEQKVHLETSWTCETRGLEKVNAIAASKDWLAIGGFGKDEKGLVEVWSVSNDSELTEITAKLSYRATEHEKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P245</accession>
    <name>A0A2R6P245_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000548">
        <property type="protein sequence ID" value="PSR83957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P245"/>
    <dbReference type="STRING" id="98765.A0A2R6P245"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="137" mass="15312" checksum="5C0F970137B4458C" modified="2018-06-20" version="1">MATRKSGEHVHHCFNYLRQTILCGANPTLEPVVPILGVRSVNAEMPRVCRDWTAVYELVEKNFWGSSVWKGTNGTDAQWYGHPVVWPPLLGYDGDLVKKKSAHELASCPQVFFPHILDTVANHGQALRNSIMVCKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5F3</accession>
    <name>A0A2R6P5F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000528">
        <property type="protein sequence ID" value="PSR85653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5F3"/>
    <dbReference type="STRING" id="98765.A0A2R6P5F3"/>
    <dbReference type="OrthoDB" id="3259646at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="270" mass="30576" checksum="FA8B95FC45B64956" modified="2018-06-20" version="1">MTTITHAQDTHDDIPGLLAIFRDLYNSIQKSQQWDVEEGIAAVLIKCRENLPLLRPDHSRLPRALFVIAAALILRFEALGEVADVDDAIIYLDESLAIPQSWQDESVHDEIVYVAALSLTCLGKALMLRFEHWKDVEDMAAAIENYRIALVLVSSHNPVRQECLVALRRASVLKFKTYGRKEDADEAIQGPPKIPIYATPFSVHILENFGEMLGPFPYKKVPKWVYAFSSFPYKGGISTECFVRYPYTKPGWLSGISALHLVVWSRVRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5K5</accession>
    <name>A0A2R6P5K5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMN-dependent dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5K5"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR85844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="9032" checksum="56CD52EAE47D63A3" modified="2018-06-20" version="1">MGRAFLYAQSVSIPCLRSCDISKRMTISSQAYGAAGVVKTVRILEREMLTGMRMLGARTVNDLRPEMVERVDWQPIMPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC51</accession>
    <name>A0A2R6PC51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5'-Nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC51"/>
    <dbReference type="STRING" id="98765.A0A2R6PC51"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="149"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR88869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="495" mass="54733" checksum="9AAC44EA9B6E0B34" modified="2018-06-20" version="1">MLAKALNAHSPSVQESNSTASTHGVDLILGGHDHLYYISKGVTSWEGYDVNEKVLGAEADEGDVLIVKSGTDFRDLSEFTLELEDTPEGSVRKKLVKSIRGVHYETKPGSKSSKKIAKLLESVLSKLSEALKAPLCKTEVVLDCRSSLVRTDETAAGNWFADVLRHAYDEALCLKTSGGSDGVFICGGTIRGDSTYGPGIVTLGDILEILPFQDPIVVLEIDGATLWAALEASLETWPAQEGRFPVISGFRVSWDSRRPRGQRVLGVWLVQEASGSTAGTPFHSGASTPAASSAANILDDVNRPLHTLVDVEEVKNEKGGRKYKIVTREYMAQGHDGFLALKGQTYLVDDESGQMMSTIVRKYLLGCRFVNRMSRIETQERIELLLNDSTNELINREKARHEQYAKHLSRKDAVSRWRRAMHLALRWSRAHYRDNIHVTEKEHMSDVDCFDGAGLRSNKTEEKEEAEVATADGEKDLITIHPVVDGRLKDEGRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG41</accession>
    <name>A0A2R6PG41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG41"/>
    <dbReference type="STRING" id="98765.A0A2R6PG41"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="383"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR90589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="733" mass="83307" checksum="AE94C6AC249A8016" modified="2018-06-20" version="1">MAYNPLQDVPLSGKTQVTDYSRWRLAVTQDGRHTWHYLQNDEECAKWPQVALDKYWLGLPLDLPALPPAKDPLSAARNGYTFYKHLQAEDGHWPGEYGGPMFLMPGLVIGSYVTGMPFKQEEKKEMIRYLLNRAHPDGGWGIHVEGDPTVFGTALNYCVMRILGVNAEHPTLVKARGCLHKLGGAAGIPAWGKFWLSILNVYDWEGNNPVPPELWVFPDWLPFHPHRWWIHTRTVYIPMSYLYGIRYKMEENDLILSLREELYPQNYYSIDWPSQRNNIAAADLYMPHTTVLDTLYLILGAYESCAIPPLRRAALDKCYKLVVNEDENTGYQTLGPVSKMMNLIVRAHVDGTESEAYRLHMETRDDFLWLGADGMMMTGTNGSQLWDIGFISQALVETGLAKEEENRDSLIGALKWLEMAQIKEHPKHFEVSYRHPTKGAWPFSTRTQGYTVSDCTGEGLKAVLYIQNDVAGAPKLVSYRRLADAVDILLGMQNSDGGFASYELIRGPGWLEWLNPAEVFGDIMIEHSYPECTTSVITALSIFKKHYPDYRHKDIERTIHRAVEFLHKSQRPEGGWFGSWGICFTYATQFALESLSLVGETFETSEYARKACKFLISKQRADGGWGESYKSCEVGKWVEHAGTQVVQTCWATMALMYAEYPDPEPIERAVKLVMSRQRADGSWAQEAIEGVFNKNVAIAYPNFKFSFTIWMLGRAHHYLENLKNKANGAVGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PK21</accession>
    <name>A0A2R6PK21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PK21"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR92231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="8828" checksum="2C722F9817C04889" modified="2018-06-20" version="1">MSPQNTTPELSDDDRAGSSVGSSRTMGGASRRRSTRGRYKLSYVIDTPFSRKYLQPAINAAAQRASANHQSWIMSVALVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNA7</accession>
    <name>A0A2R6PNA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNA7"/>
    <dbReference type="STRING" id="98765.A0A2R6PNA7"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="244"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR94089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="703" mass="77298" checksum="F8A517BCFC47ACCB" modified="2018-06-20" version="1">MFLAGYQEGDYCITYAEPEDGDYDGHKGIEPRPPVTFEHSAGTITGESPVFYAVFDTPRVLSYREFRVVLQRPVLTVTARLLSISLLFFVRPDPRFDILDPTITSFYSPNMQLTSGNFTALLQTLGLTQGLFKPIPDLGVQGQVASGYPHSPAVPIRVSSGDSAQTDNDPCYREPYYPAPLGEQTFPPFDPAKASVYRYRQQQFVHEAWMTPSLFTCASGDQISELDIAYGWGSTTAARAVLERHWDTFIQNSDFQYLASIGINTVRLPIGYWSLGPDFCQGTPYANVADVYQNSWPRVLRTINMAEAAGIGVLVDLHGAPGSQNGQQHSGISDGNTGLFDDPTYINQTMAVLTFLTEQLADVSNVVGIQILNEPQNVPSLEDFYTTAINTMRQVSPEAARLPLYIHDGFDLERFSEYVAARTDFVVQDHHSYFVFTPSDDSEPASQHTSDIQNGIAATLTSASNQQRRNLVVDEFSCALTDQSLQGESDPGETRREFCTGQMQVYANATAGWSFWAYRKEQCEDDPGWCFTAAVGNALPSTFFSYGIATTSQEPSQLPDMSALAEGMSPPSMSAQSTAQSPYDSTPYPGYDSANPSVPPPFRRMIQSRQKLARTPNNLNERDEDNTGAIQQTMTRGYSDGFLTAKIFALYGMSKLGFTGQYIVDSMAALGPDVVHPGMEGYYHDWFTTGLADGEATVGAGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNH1</accession>
    <name>A0A2R6PNH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNH1"/>
    <dbReference type="STRING" id="98765.A0A2R6PNH1"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF52">
        <property type="entry name" value="MITOCHONDRIAL CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015354293" description="Mitochondrial carrier protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR94064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28476" checksum="84E11D04F3AA3463" modified="2018-06-20" version="1">MMVNVMLGSVLWTTYSEASTIFEPHFGSPIALAALSGALAGGAQALVAAPAENVRLVLEGGSSSTGWSHAWKEVFRGTNAIPAMSKQDQLHEARQVRDWMREVGDMAGRGWNGWKWGVAKDICGFSLFFSIFELTRRAAVRLKTASQALIEQKTFGVDDTNRLNRHVPRVVHAATLVSGGAIAGLAYELCCRPWDVARKAVHLDRVVSGSSYHSVPSILMRKLKGEGWLAFNTNRWFSRVPTDLDFGIRQDPAHTLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVF0</accession>
    <name>A0A2R6PVF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000436">
        <property type="protein sequence ID" value="PSR97473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVF0"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR97473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="729" mass="83270" checksum="6C5A62D68FE57071" modified="2018-06-20" version="1">MSPPLLPPNNSPTTHVIEVANFEHVHLSPPPNRSSSIVDMEDHQLEYQAIAYSFGPDELRDCIVHYLNKISESIYSTFKCLKELLPLAHHPNKRVVDQPQIIGVYRKERSQDWSKHTVPWHRVETVVQVIGKKEDFQEHLVYTKHLLQARPDCPGVYGVSVLHNEIENEVQYRILWADAAGIVLSEWYPLERQVLPLPLFALVYSFYAPPNKHHLKDPTIRWTEAKFLSRARWTVKCHKREYPGCHILCAADPFDRRTMVFYYYKGDDLCVIKDAFWDPNNTQQEASVLNTIHKQGILPGVVRLQDHESVLDCNRRRIVTAASESLGISARIRNRMVLTSVGRKLTTADSIKDLLMAIYDIIEAHRSLCMDRSILHRDMSMNNILIYPQHDPASEKRFTKNPPKFISDVVRDKCKDSDRSRGLIIDFDNSASLLDKERRYKADQDLTCCVGTPIFIPRSAAITAPLDVKCFTPMPQLTGLAKSLYVQAYSQQSYDLYADSEGRCHSVPDTLKTKDQCSEYAHRPDHDVESIFWSLIYVLLQLQPLDGEDSNVSGLSEDALLAWKHLHGHRVEAATKTSVSIDTRDVLFEFCAGDWKKALHPGLSSLAPLLAKMSLQVWPEYGLLAESPPREHLHEAMRRLLLQHIVDMDDPILLNPRNRRPVPRNVDHVTNVTGVDVDGARFGWLHLPHPKEQPEGEKPKIILRVPAPKRRREGDENAGGPPDKRQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ51</accession>
    <name>A0A2R6PZ51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000418">
        <property type="protein sequence ID" value="PSR99447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ51"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR99447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1274" mass="140746" checksum="6420E394DA0034D2" modified="2018-06-20" version="1">MNAGSQPILHAAPASQTTVAEEVVKRDQEVIKDYKEDIDTLLVFAGLFSAVMTAFLIESYKTLLPPDQGNPAVELLRQISSQTRSYRITVDFHNATASEVSTSSTFKPPLSAIRVNVLWFASLIFSLASASFGMLVKQWLHEYLARAGTSSQARLRILQYRRKGLTQWQVLTIAGILPLMLHIALGLFFIGLCFFTASVHPSISRTATPLVAGWALCFVFFTLAPMLSPRCPYKTPILKSTMQSTRRYFLPTLRALVRLPPLSLVATETMNPIRQFRRLSNVILYSHVMEQILGGLRRLAHEQDDREEDSIAKDEGNDLQNLINADSLVTDDNLLGSEMRNLINEAKAPPNEVLEFIESILKHRGVDTGSLPSPLDLRPLTLQGRTAVLDIISDASKRPPSSSSPAWMYTAFLVFISPSNGHDIAPYIKTIQSYITDKSFELPDLKEVQWLDEKHFDDMMGNIGKALQGLGGKHTFKLLNSILSWRLKRRAFDFKLADIAAIDWEEYTTSASLMKMVSMLLGVLNGEIDRISQAQEFRWDKWTDNILKAIIGLVDALREDFHSDAIAEVDRMLLRMTSSPELWWRLIRGIAEYPRPMVDPGLILPLRVIEGNKASCTEFVLTNFRDFVTAHPDGGTTLMLCYMTAFMAYLQPESTVLATLSPILASRLSQSGRPTGQEKTLAGECLQLIQSSDQKSGMTYEEWLRSFNVSPNTFSDEFIEALSRIARSGLEKTWRVQRLEHIRKQAEVPEAVVAQGPSVLQQAKRKFTQLWNPTRNPGSPSAGEPRSLPAVTEEAAQAAGESQVKLINKDGGDAAMPKGSSGNGGGSGRSSAAGRPPSCQPTLDRAPSDRNRGREAVGNPHRQSSASQQPQTRRPTRQPTVYPNIAKDDIARGVGSTLRQASPKGTGDSHAGSQVWLDADRMQESPETYIAGSGRSSTNASLNRRTDPSRNTRQMSRDMELDSLRNTTYQRRHSSQDTIKAPGVSRTTPNANEEHTGGIGERATEDRVGRSSVEPPSRQPTRQPTRYRGSEGESNDRNTGNPTLQPDYPAVRRGTTRQPTRQLSTADTPKANEENNGGIGERASEDRVGRSYVEPPPRHRGGEDESNDRNAGNLTLQPDYPAVRRGAIRQPTRQLSTADTPKANEEHDGGIGERANEDRIERNSVEPLSRQPGSEGESNDRNAGNLGHAVVRRGTTRQPTPRLSTAEVRITLTGPRGDDEHTIGPSSRASTVRRSESNSTRVRGISRDSRLPDDLTSADNTLDTHIDGRGHGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2A0</accession>
    <name>A0A2R6Q2A0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000405">
        <property type="protein sequence ID" value="PSS00870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2A0"/>
    <dbReference type="STRING" id="98765.A0A2R6Q2A0"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="26"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS00870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="774" mass="86037" checksum="16E0624264859AAF" modified="2018-06-20" version="1">MSGGEQEHPMGKVTEEPTSNIGKTGWSAIEDYAYKHDANSMKVFSEAIDTLLVFAGLFSAVLTAFVVPAYGMLQPDNSMLLLSGMSSQLSSLTKAVSLFVSSEVPPDLPPSAAPSLAFSVSSFARWINVLWFLSLIFSLASALFGILSKQWIREYLQWNQTTAAPRENILVRQLRIEAWEKWKVPAGIAAIPALLELAVVLFIVGLVILLWTLDTIVAIVISVAAGILLSISSTVTVLPAFFQGCPYKSPTGWACVFVYDTLVGFQDTFGEALTHFQSWRERDLSNNGSISTEISDLADDSLISNPSQPVDDSQPIEDSGWVNNSPWEDDLRRFNEPWRREDPRRMELATRRAEIVNTTAQFTPLIRALVWVRQGSEDARLREEVVRCMYALPSWKAWDLQWYGSSYALWKLWLVDGGMDWQPFDSLLDASIHYTGCQTMNGYTVDVGSSQSGKWVLSNLIGADIQADFIGEHRSVSTMQKLDANRSAERLVVHVVLLSSLGRLLRSHNDAEAADDLCGRLIRTYNQISTSSNPLYLRGMHTMLLEAACSLGRVCIAQEAKELSDLGSHTIRWAFGAQSLREFFAILDQFAFIDTVTTVREPRHTDLQDGYAMPVIIGARDLRYTDLQDGYGRLMPVITGDRVGEHYMKLRFSVLSFLNKPDGRDPGNLGSFPASPNRFRVPGRSRRPDSRPMGPRSPRGPCGRRLPVLPYRNIVSSDRSVGGQYDITLCGSEQWRTEQLRRAGGQDSGFVTLIQSGPMTMGYPEIVVTAADDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7G9</accession>
    <name>A0A2R6Q7G9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000385">
        <property type="protein sequence ID" value="PSS03518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7G9"/>
    <dbReference type="OrthoDB" id="3248529at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="558" mass="62268" checksum="9BB055A95210C40A" modified="2018-06-20" version="1">MVAASVPQPTMVPPPVPPLPDPRQVVSPLDPDKVEAKLHELGILAQWQHVVDGLRSGFDVGATAPIPHSLQFRNHTSSELAPEFIDEYITQEQAAGRYSQAFDPADLERIIGCFRTSPLGLVPKSGTSKFRLVQDMSFPRNDPLMVSVNATINADDFPTEWGTFAQTSELILKLPSGSLAATFDIKAAYRITPVQPAQQNALCVFWRGKVYVDRAVAFGLRSSAGVFGALADMIIAIYRASGFGPLTKWVDDFLVIRLPGQEWTEADFIELTSRLGVPWSQVKTRPLAFCQRYIGFIWDLANRLVCLPKDKLDSILLLIDSWLEQKSTFSAHEAAHLHGKLVHISCIFPLIRPFLPSVSRFASSFHSARGRLHAPASMQSDLTWVRYIIHKLPNEMPLSLPEPLDIDWWGDASTSFGIGVVLGRFWGVWRWRPEITVGPRQEFDIGWAEAVAVELGLLMAIHHNLLSTRPPHRNAILVRSDNSGVVTVVNKGRSRNRNTNMVLKKIYSQCADQRVHLVAQHVAGRTNISDALSRGEVSTFLQAFTHILQRRRYCSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7H5</accession>
    <name>A0A2R6Q7H5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000383">
        <property type="protein sequence ID" value="PSS03711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7H5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="23626" checksum="3350FD99D3C42836" modified="2018-06-20" version="1">MIVGTHLSSYRLLLQRLLQMRTVTLEGLQAKVLGDQGGDWGALSFLTEETSAHLQSFSFDPALFVNFYEWFFPKYLRVMAYLFQHVTTLSSLRTFTLQTEIPTTEGLVLSRIEPKLAAAEDAPYEDVRPQINVWSRDGFDWSFLRTAFGDLSELETVTFVACSSRFYVGQETEFKAIRKELPGLEARGILRYEFIESHDGVNGIHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB76</accession>
    <name>A0A2R6QB76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB76"/>
    <dbReference type="STRING" id="98765.A0A2R6QB76"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="1">
        <location>
            <begin position="56"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="369"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54918" checksum="D29ED176F21D9715" modified="2018-06-20" version="1">MDYPFNVRSFFTRQEQKDIGSGLVLWRGYFQSVRPAVGKMLINIDISTGTMYKPGPLIDICLEFFEKQGQPLVLAPARGLPERERARLSRFLSGVRIETLNANGKPSGTPRTIKKLSSAGANQMSFTMREGGTLTVAQYFQRTHNRALRFPDLLCVEVGNGALIPLEMCKITEGQIMRKQVPPEKTKAVLDFATKRPPERLASIKAGLGVLQYGQSEYVRQFGLQVDEANGPLSISARVLIPPTLKYGPTSRQANIVPRDGAWNMIDKRFYQGTTIERWAIVIYERTNRFRENDATEVIAGLIEACKNVGIEVREQNPIYRYQNAQGRVADQLRAVGSECAAKNGGKFPNLLVIILPDNATDIYQAIKQINVKLGGINTIPDPRSVQILTDPHNPTMVMGADVIHPAAGSVGRPSFTAVVANVDSDTAKYIADCRVQTSRQEMIEDLESMAEIREKKANSAPKRIIFYRGMSGLLYSYMVDASIMPWKELRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBN5</accession>
    <name>A0A2R6QBN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBN5"/>
    <dbReference type="STRING" id="98765.A0A2R6QBN5"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="16"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS05524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="225" mass="25117" checksum="5219278B6D9EF208" modified="2018-06-20" version="1">MSGADEPSRVPLTLYNFNSKADIQQFALGVDSDIGGTSTAHLDLDESTAVENEKTTALSPLRPTGKFWGEMRLGVRQGMEDRLRGGYAGFRTKPRTTLFGEMVDDVSNHRFLALRLSARGNPRTRNSYYVNIQTDGPITSDLWQHRLFFHRDDGGWEDLFIPFENFVLTNTGEVLSKQITMFRERIRTIGISILGGNSGVEGPYELGIDSIRAVNEEDVSNPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEH9</accession>
    <name>A0A2R6QEH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000362">
        <property type="protein sequence ID" value="PSS06530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEH9"/>
    <dbReference type="OrthoDB" id="2672295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52058" checksum="54F7F10A6E0A524B" modified="2018-06-20" version="1">MERKASQAAQRERAEQDRLAAAEAIRVQQALEAAVFLAAHCRKSLSPSLPPELLTKIFKSNLRYYDKSGTISDHDCHKVYKTERELILRCCMVSKEWSASAKRIMYTGQIYLYHTGAIRRLIRTVQEDADQIHPIQHLQFSDFYNTDDFQRPAAELIALCPELATLGGYSGSLYFDKLTPLPEFTHLRELRVSNQVLSSLAPLLHRLPILELLEIVYVIDDEPPRVTRVGAPLRAGLRPRMNGVPPPVFNLKTLRLSQCQLTLAECRWLFSSSNAIDYAQLQEIHEYSVALGEVIGSSVSRLHIKGMMDVPQRGDPHLSQSLSLYTNLRALQISGKDWPWPQLLGSITSSLHAISISYSAPGTQALVSSLSDHAWQKDLETVTVYHWANVDYFYGIKQADVDAAKESLEVACGKRGIPLIWIKEGESRTVIGYTGVGFEPTQGGTSINIEEEPVMHVANEQETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEV5</accession>
    <name>A0A2R6QEV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000352">
        <property type="protein sequence ID" value="PSS06859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEV5"/>
    <dbReference type="OrthoDB" id="3257409at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37610" checksum="3857C7FB2DE08FF0" modified="2018-06-20" version="1">MDLDPIDNSMDSEDSDGSNISGAVYDEGDPWGNYDEGDFGGAVVNGLDIDNELAIYDICNNILNDRDRDDIRAFYLRIKSNMSRFNFDLMCRSFSHKMEINSLYTITRRMAVLSDVNVTQYDCCINSCLAYTGKHTELDECPYCHEPRLDKDHQPRRQFMYIPLFPRLAASFQSPDMINKLSYRANFQHTVGQIHDVFSGENYQAMKSRRVVVDGEILPHKFFSDERDIAFGLCTDGFLLFGRKRGGPSATPLLVKNYNLAPHIRTHLENLICVGVIPGPKQPKDLTSFLTPFDDECASMVKGISCFDSMSRKVFTLHAYLSQIFPFRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUI9</accession>
    <name>A0A2R6QUI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v3275</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="MLYV02000311">
        <property type="protein sequence ID" value="PSS15399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUI9"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="FTP" evidence="15">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="14">
        <location>
            <begin position="61"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSS15399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="434" mass="47119" checksum="7D22B61EB02D6908" modified="2018-06-20" version="1">MHLHATHEGDVARYAYFKQTINGISVANAVANVALNKANKLVAIGSSFVQNLKANSAAPSISIHQAIATAESALNGTFEAINFPQPKLIYLVKGDSSLALAHVFQVRNGGSGSWYEAYVDAHTGEILSVTDFVAQATYLVLPITKQILTQGFEDLVDPYDIEASPLGWHNDGKTLSNDTAGNNAISFNIIQADVVTESASNLTFLFTQDPTLDPTVTVNLDAARVNAFYLVNSVHDIAYRYGFTESAFNFQTDNFGLGGKGNDRITISVQDGGGVNNAEFTTLPDGQNGQMRMFIWDYTVPRRDSDLENDIVVHEYTHGITNRMTGGGTATCLQTLEAGGLGEGWSDAMAEWSEHTDANITDYVIGPYVTNNTAGLRTYPYSTSNVTNPLRYSSVAKFNEVHQIGEVWANMLHNIYAALIQQHGFSQTAHTDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0Z6</accession>
    <name>A0A2R6R0Z6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000286">
        <property type="protein sequence ID" value="PSS18907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0Z6"/>
    <dbReference type="STRING" id="98765.A0A2R6R0Z6"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS18907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="163" mass="19001" checksum="9157AFC463529E4B" modified="2018-06-20" version="1" fragment="single">VAQILGTTKHITAKDSKAFAQEIGKYIDSKDQKRGDKKEKNAKEKDKDKGKRIIEKQTKNVIKEFRVHLSEARKLRKEAMDALAGLKKRQNKAQREECVLFTQRSRILLPQSDEMLIFFFFIKFSRDVLKEDLRIGLKDLDDAAAEQRDPDSFDPTRNIRSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3X9</accession>
    <name>A0A2R6R3X9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3X9"/>
    <dbReference type="STRING" id="98765.A0A2R6R3X9"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="181"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS19953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="774" mass="81693" checksum="D0A2B728CDC57B8C" modified="2018-06-20" version="1">MPNARLPGGPQPAPSGGFPPLHPTNGAPRTDRPQDRILQQLSGLTGTTITLSTKTNQRYEGVIASTGGDGDTAGVTLKDVKEITSPGQPLKDVLFVASTNIETWSSGPADAKAPNGDTFKTDIDISFKAAPRRERELQAWADDIPENSTASGRSGHTDELTFGLGAHGNNWDQFAANEKLFGVKAGFDEEAYTTKLDRNAPDFKEKEKKAQALANEIMAAGTNNTHIAEERVMNFTGDNGTNEEDKYGAVVRGANAYVPPGARKGGIPGIPSASKPDVPKVAVNGQETPSAKESPKPASPAPGANTANMPSADPVPAFRNFVSTEKDRLLKKKQALMKNEMDKRMAELVKFSQTFKLNKPIPEDLVTILAKDEDKQRQIREKSTKDAESNHARSIGPSALTGPALNTSSTATRLPSTPSTAKIPTAASPQPSGAKAPAVAKTSSATGTSGKESAASKRINMFIQPIPPFKSKRSGATPPTPAPGASTPSRSSTNASNTSATPLSPTSANRLNVNASSFRPTTKASAAQVSNNGNGPSSSSASPKNKPSDSTPSSQGPPNPFFGTRVIKKTPPVHLKDDFNPFKYHKVADASQVAAIWPYSGKRYMQMFPPLPVQPQQQSPHMAAPVPPQVMPPQTYEEVSDPAAQAAARGGFVYAYPPYGYPGQPMMPGMPPPGPYGMPQYMPPMPYPHMPPPNAMYPGTPMGQMPPPQAYMAPPPGSYPPPPNGTGPRPSMPPTPIPSHAHPYYHQSPQRAPGGPPHPYEGAPAPPVPMGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R749</accession>
    <name>A0A2R6R749_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000278">
        <property type="protein sequence ID" value="PSS22601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R749"/>
    <dbReference type="OrthoDB" id="2750697at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS22601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40495" checksum="A65C356A9A54D4A7" modified="2018-06-20" version="1" fragment="single">SSDADWSRFRLYAARIQVLLVGSGSRAGCPLYNKGLAGLPGNEVVSILKKYLAPSSNGLLPNLRKLDWDAKDPKKTPYLALLFNSSLLSCHATGCNEIEALLGSLLDISPKLRLLELKSTVSTTPIPIFQYLRTLHVMENNIPYVGSMLFLEDLHWAPRGDQLAAQLGKDLDIGFPALRKVWFHVDVTNLAHVVTFLYLIQTTSLCSLTLIATSETQSDETSLVRRLLEALPRHSGLQEFAFSLRMRAPLVLPNSCHLNPLARLSELQSLFFSGIDFHVTDDCIYRLSSAWPKLKKFHIAHLNTSPRPLTTLIALQSFAIHNPQLTYLRIWLDAHPVTPADSKAQRLDHIRIHFDYSPLSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHS6</accession>
    <name>A0A2R6RHS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHS6"/>
    <dbReference type="STRING" id="98765.A0A2R6RHS6"/>
    <dbReference type="OrthoDB" id="2591106at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="3">
        <location>
            <begin position="632"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS29575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123442" checksum="2D0F57C49832071B" modified="2018-06-20" version="1">MVPSIPSDVSDAGRSTVRDAQLFPSDEALSQRTLWICLLVVMGWSILGLVGFLPIYVVGTPCLAHSFRPSKFTGAYSVLQDLSLLRLLHLLDDGSVTANTNILSREIVNGTDLSPEARTRIIIITVLTIVLGVLPVLWKLIKEFNKLVGYRRHWVEVRCQGIEMGWLSARVAPGFIGWGERRLKDYIVRIGLSASLDAQDETRRNRRTRRNHEWSVEARGNLEIDIQSLFSIGNTTELAVLIDERDEILENLEIAETKYINSFKLSTPDPSIADFFPSIPLMQIPDDPPPVPPKPEISRPRPLGTPAVHSRRRRGRNPAHGSSSLPPTSFVMPSQYYKLRNVEGVSGGQFTDAEGSSPRRRDPSLTDSFNQRVIGSRFQEVNRDSVAFGRLPMGSQVMIEKDGRMGPVPLPTDSPLPDAAPYAPGAHSSWDTTAFNEGVPSHQWWSHQPGDSIQEVPEETELGADWVDVLHEDPEAFQNGEEYNPNATPPRRRRPRPPRAKNVVTQDDRRETFPLRNRGPPEMESQLAPHLRLQPRQPFVRPLSGLDHNDLGHIYEDISIWRAELKNVNAKIADVQGGCYNDIADGARIKGWLMVGRGLRFIPGMQLIEGRAKEDIRWDELQNEGGATMELAYWTIVTVVGILLGICLTAVAGLCLATAPEFGHYFPFFMPLVATNDLGGGVAICLASAVAVTLFISIAWAIIQYAGQLRNTVSLSGKQMNDFRTIFYVLFVVGTVWLFVVGAVLFAFGALSIGLDEAPTIANGAIYMSAFALVLIVNVAIIFPALLMLQPLRLWRVIRDERAAITPRQRFRAVYPRTYNPSYATACCVLAVLLASAFTLVFPLVAPAAAILLFLTLIAHRFLVGYVYGRTHSQTGGLLQIWLLKRLGTALALQPLLLGLIFLSRRIWIEGGILCGTALLVVLFVEGYCTWKTRLPGRKTLSDATEDALNIFMQTAHPQTRDVIDEESTSLVSSGRNTRARGSFASILDMMSLTLAVMPSSSQSRGPVPLETETLDDLTATERAARTHPDAPPHLPPLPFADHAEEMSGILYAPELLAPPPVIWLPNDIGGIGRSEAFDLQRYHELQVTLDVRSREDALPRRSLSPNTPRPRQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIC9</accession>
    <name>A0A2R6RIC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIC9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="297" mass="34574" checksum="C2E7FB0B5CCCC237" modified="2018-06-20" version="1">MSAQNLFDYDELAADPLDLSDSRQNRHEDTHDETRSRDSEPEEETEYSRDGSTTLRDTPTVYDEDERPLPEPVRKTIIDTHQTVWNEFYRWEYDFSAKKIAIFADEPQEEDSYAYLLAAYDRSVKDRMDVDSDIPQAGASDDDDSAPRKFTIYSDFETKTTTSIVLTRPITVTPPLPPHPKYEACTPSDCNIWLNGPKPVLNFIKYDGEIDKHGLEFDSRKYMSDFDRVTWIDDRIDPDHLVIASKTVQILTEWQRNKLDSLVGNKIRVTYEDIDRLGIFSAFGKDVEDLEFEMRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLG6</accession>
    <name>A0A2R6RLG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000243">
        <property type="protein sequence ID" value="PSS30862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLG6"/>
    <dbReference type="STRING" id="98765.A0A2R6RLG6"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="4">
        <location>
            <begin position="99"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS30862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="272" mass="27961" checksum="DF2A7AFF5EB7A1AC" modified="2018-06-20" version="1">MVPLRSVLSVGLFSQTLLNPPNGAHKILLTNDDGWAVAQIRAEYNALNAAGYDVVLSAPAENSSGSGSLSVPATPVTYGCEFGSCPEGAPAYGFNASDRNKGIQVFGSGTVGAACEAAKEGIPSIAFSGSSSSTAHEGWTALYNIPPSSSILAAQAYSFATATFLSSFFSQPSSSPLLPPGVTINVNFPTLTDECTASDIQWVFTRSLPSIFSNDVVVCDNGGKLPTEGDVIAAGCFASVTVLDADTKLTVGKELQADVFARLSGLGFVCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLX0</accession>
    <name>A0A2R6RLX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v2431</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="MLYV02000222">
        <property type="protein sequence ID" value="PSS31018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLX0"/>
    <dbReference type="STRING" id="98765.A0A2R6RLX0"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSS31018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="484" mass="55569" checksum="2094F242CD999A3D" modified="2018-06-20" version="1">MSVRHRAKVVGPTEEGKKLDKLLDSHTDYEFGGPWGVLAIMSGFPLLMYYLWICLVFYDGHLVFPDALDDLQPFLARMWAHISVDASPNLYACKVYLGLIAYQLFLAWIVPGYSQEGLPVPSLAYKTLVYKCNAIGCIYITWISAIVLHTTHVFRLTQIIDNFGHLMSVAMLVGFAVSFGMYFLTVATGNQIRMSGNLLYDVFMGACLNPRLGPIDLKMWLEVRIPWVLVFFMSVSGACKQYEELGYVTPNMAFMCLATWLYLNACIKGEECIPQTWDMFHEKWGFLVIFWNFAGVPFSYIYSVVYMANHDPANYRFSTPTYVLLYGTLLTAYYIWDTAMSQKSRFKMQTQGITTFRKTFPQLPWGTLKDPKFIQTAHGNRLLVDGWWGYSRKPNYVADWIMSLTWGLCQGTCSPIPYFYSVFFVVVLIHRCGRDFERGYAHLNMAHGFVVEVMHSLTQPLRSTWAPGEKVCRRLGFVQVKYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLX4</accession>
    <name>A0A2R6RLX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v2446</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000222">
        <property type="protein sequence ID" value="PSS31033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLX4"/>
    <dbReference type="STRING" id="98765.A0A2R6RLX4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="132"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS31033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="637" mass="68824" checksum="0413C1A0D05CD54A" modified="2018-06-20" version="1">MSRSILAPIRILLEVIGFQAHGKLACLKEAWVIGYLMGAHGRLPSSKFCTDAVYPEKRRAPYASPVQSIKPFPAPALYLAVLSPQPPSPYQPFSALPTPSAETLQTMAGGPAASGPGLGANAPKSKLAGILMVSFAAFAGILFGYDTGTISGITAMKDWLRLFGQPTTDLTNHPTGFAITSAQQSLVTSILSAGTFFGALGGAYIADAVGRRGGVFLATAVFAAGVSLQTGCHQWAAFIVGRVLAGLGVGLVSILIPMYQSECSPKWIRGAVVSGYQWAITIGLLLASVINNATKNRDDHSAWRIPTGIQLIWAFILTVGMLWLPESPRFLIKKGRDADAAKSMSRLTSLDPTDPEIEQELNDIRANLREEQELGESSYMDCFRASHNKIALRTLTGIFIQAWQQLTGINFIFYYGTAFFANSGIKNPFLTQVATNIVNVFMTLPGMWGVERFGRRSLLIWGAVVMCICEYLVAIIGVTISIDNTSGQKALVALVCIYIAAFAATWGPIAWVITGEIFPLNVRAKAMSLAVASNWLWNFGIGYATPYLVNVAPGSAGLQSKVFFIWGSTCACCIVFSFFCIPETKGLSLEQIDLLYQNSTPITSVRYRQEMLANDVHAADHGPAEKHFDEKDESEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLZ3</accession>
    <name>A0A2R6RLZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLZ3"/>
    <dbReference type="OrthoDB" id="2804008at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="201" mass="21988" checksum="543A6CA36BEF9BFA" modified="2018-06-20" version="1">MRASPSRKVGPLEVLRVAMMQGGLDDLRNDVARALRRNDIDPDVLASLLQGLQGIGIDFTNARQGLIDFQLKASGCPARSCVSYKLKLEGRCGTRGNGGKEAVEEDSGGLARRRRNYPHVGEPSTISVCDSRQFSTETGDPCKNCAVQHDESAGACFRNMMMVEKENVNDSPQKDATTARKKTGVKRPRRKPTGGKKWAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPZ4</accession>
    <name>A0A2R6RPZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000198">
        <property type="protein sequence ID" value="PSS32091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPZ4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6591" checksum="6B16928435458193" modified="2018-06-20" version="1">MFLTFSKYQGQPGDMTSDFRQDDARSTQSLGAERWAIQERFATTTRENGQITTEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ85</accession>
    <name>A0A2R6RQ85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ85"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ85"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015310020" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS32183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="164" mass="17080" checksum="5B30396E528C7BBB" modified="2018-06-20" version="1">MYPRQFLVASAFALICSVEGLNILLTNDDSWASANIRATYDALKADKHNVLLVGPAVQQSGKGGTFVLPTVNITAPGGEFGSIPVGAPFFGSDVKDPNLMYFNGTPAATAIFAIDILIPKHFGSDGVDLVVSGPNEGQNNGPFLYTLSGTIGATYASVERGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ95</accession>
    <name>A0A2R6RQ95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000189">
        <property type="protein sequence ID" value="PSS32192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ95"/>
    <dbReference type="OrthoDB" id="3062869at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="89"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS32192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="26783" checksum="7C70AEF9BB63D28D" modified="2018-06-20" version="1" fragment="single">LTPNIKGAYFKKNWDTVLQREAESLIEKVFRERYTKLYSESVPPEPTHRQPIRSKRSLRALSDDESDTAAPAPTPFHSITKPWMSEFQRYLGTTEEIQQGTSTIQWWGANAYWYPVWASLARDYLSIMATSVSSERAFSQGGITLSKRRSCLKGDVVEALQCLKCMIRRDLLFKEAAPSSATEEMLDDDLVEGLWTDSEPVLVDTSINEANTQVDLEDESQGAWDLILVEEDEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVJ3</accession>
    <name>A0A2R6RVJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVJ3"/>
    <dbReference type="STRING" id="98765.A0A2R6RVJ3"/>
    <dbReference type="OrthoDB" id="3064136at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="380" mass="41657" checksum="6EB63673AE72FCAC" modified="2018-06-20" version="1">MSKLDSAITLDIEDNEEVADIFSEFGLQPQSPKLAEALFGSARQRSLDKVKASSSRRDSPTLPWRNPSVRSTAREPKRADRPSDTTFPPRSNSPDIDAIIAKTPRPRRSSTSVLSTPSPASRSLTSLGVRNRSPQNIGAKKVARDETSLISDFGALLEADSDLEDDNGSETDSSLDIHTPLPHLMFRDGLLSPRSKLLPQSSSSPFSYPEDIINSIDPRAASVLSVVSTAGSAMTKSGLQKDPRDTQRRRIRHRDGRLLRAGMGLTTGLGWSDSEDEDAPSALTRRLISTTIERKRSDSLASPSRRTSQYDETSRFGSPVPPSKSSVRVIPFSSPGHSDPNFGPRNRSSNTEGESRFFRCYQHFIDGIGKVLHLISPFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW18</accession>
    <name>A0A2R6RW18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Membrane fraction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000140">
        <property type="protein sequence ID" value="PSS34209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW18"/>
    <dbReference type="STRING" id="98765.A0A2R6RW18"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS34209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="33828" checksum="01051DDC04531D96" modified="2018-06-20" version="1">MSSEQTSALAVPLPPRNAADCSTLSKKPPVWSVSEADVPAPLPAKCDRHEPGRSGICCKELKGDDERTLVDPDVVRDVVIGLSDGLTVPFALTAGLSSLGESKLVILGGIAELIAGAISMGIGGFLASQAERDHYRYLSKQTSARVIRSCDGEMEREVYGVLGPIGVDEKTSRQVARCLRDVEMDSQGEGSHSDAASSSSRAEEGGLKWSSTVGLTPFLLKFGEGLEEVTTRRMYVSALTIGMGYLLGGLVPLVPYFFVPKAKVALIYSSIVTGIVLLIFGAVKARITGAAGQGAGGYVWGAFSTLMVGGAAAAAAYALVAALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZM6</accession>
    <name>A0A2R6RZM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZM6"/>
    <dbReference type="STRING" id="98765.A0A2R6RZM6"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="57"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="480" mass="52398" checksum="2ED2FAA5CE79DA62" modified="2018-06-20" version="1">MPSYLLKGGVVATFTKDNKPVAFNADVLVEGSVISNIGEGLTAPSGVEVIDCTERWICPGMIDTHRHVWMAVLKGYPQCDWLLSEYLVKSTLVLQAHITPDEVHIGQLAGCLDALHSGVTTILDHFHAANTPDHAEAALEATVQSGARVILCPGRQSPATRTLPSPEYGIEEETLKWQLEKLQEWGSRDGGKLSADGRVTLGLAYDLATIGPMEKHQEILKMARAIPVSIITAHVVKGPRILIYRDGGLLGPDVVFSHCNELYDHTAPDDEMWAAMKEHNCAIASTPEDELGMAHGNPPAFEAVERGIKCGLGVDCASINSGDLFTQMRFALQFYRGRQHEQVDRDKKTPPQHNKYNAADAFRLATLGGAEAINMSHLIGTVEVGKKADLVIFDTTSANLAGISNPFQGVVFHASNADVETVLVDGEVVKRDGKLTKVAWGPVAKELREKADRIRERHPESSLEVLWAEYYTKFGGPLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZS2</accession>
    <name>A0A2R6RZS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000121">
        <property type="protein sequence ID" value="PSS35531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZS2"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="1">
        <location>
            <begin position="387"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="502" mass="53722" checksum="D2BE7E1E26D10A86" modified="2018-06-20" version="1" fragment="single">PSNSQALVSTVLSFSIEQDRWPDWVGIDSRNQFTFNALQNFAELTGQPPNIRVGANSEDHTIWSPTVTINQDVFPPPNSVTPYPEATQITVGDGYYELSKWLPSGTRMTWGVNLGLDNVTNAVNMAKSIIKAFDSPAVRRSGVKLDLIEIGNEADLYMDNGDRPSNWTVEEYVADWISIAGPVMQAAGLHPNGDVAFQGAAFAGQGFTPTEIFDLGILDTTPGGLITRISQHRYSAAFCNGGDFPLVSFMNKASVRSNLTLFEADLSASKARGLGYVLGETGSIACHGAPGVSNTAGAALWVIDYTLQAASLGITELYFHEGVGFKYNFIQPISLNRSIIDGSPIDPPQPPQIQPSYYAGLLIDTFVGSTGSAKLVELSVPDDNISGYAAFENGLLRRAVFVNLHAWLQSSEGTGQRPSVHIDLAFSLSAGGSSASADALSSGGVQARRLVIQHADDVSNLTWAGQSYETSDVHPNGRIVVESVSVRDGIDLRATEAVLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZW6</accession>
    <name>A0A2R6RZW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000116">
        <property type="protein sequence ID" value="PSS35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZW6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="26021" checksum="57A145BC6ACB306A" modified="2018-06-20" version="1" fragment="single">HGPPGRISDDNINNEIHLALQLFDQSDNYLDLDTCHQFVMMADLVMRSLHSSWLDNESLMGTLLQKMSEAVDISLKKGYWNCGCNHDLPWISSLLPKYVSASHQFAHFSLQTVEDLPARPLWSLINILEKGLLAEGPNNQGQLLFTGKNIHTDFIELKEQVEKFHPRPCTLDGQLPPTSKDAGTGNNIIYSQSYSEEACSSVQCVPSAEEAVYWAKPCFFPGQLLWSLDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZY0</accession>
    <name>A0A2R6RZY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000114">
        <property type="protein sequence ID" value="PSS35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZY0"/>
    <dbReference type="STRING" id="98765.A0A2R6RZY0"/>
    <dbReference type="OrthoDB" id="416752at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="13163" checksum="1F075AB8CB3864D6" modified="2018-06-20" version="1">MLHLAASWPTDVHPMQTIAPPLSDRPSSPAISEAKLSSPQHPPADVAAISRDGKSLVARPRIRAASAQIIFAARNSRDFITPQKVEELEDWCGLSVLEALRFFEIDPERLHTDKASVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S049</accession>
    <name>A0A2R6S049_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000109">
        <property type="protein sequence ID" value="PSS35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S049"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="422" mass="45863" checksum="BB95C6E67A1B766B" modified="2018-06-20" version="1" fragment="single">MSTPTPAAKRYGTRKANAEKHVPAELLPKKRRNANEVRAARAAAVVEAAQAEASQNKILETIAKLQAELEAQRAKGPENVQVAMLTPQNAAAKSNARKKAGLTNAKHTTPSALVQANAMSADASLVSAANVKTPQKHALEKITRARIEALVQNLKAPKTPLGTGRGKENVPPGESATDSPTPIKKSKTSSTRHGGFLPTPPLSVVTSKKTGTNKGSTRLLPVDDVGTDDDMFGVVDVPDSNFERNEADASIHIMNVDEESDVLKPEDEEPEDHDEEDEGEEDEEDEENEGDEWEDSIEDHVLGLTAAESDAATAKVCRITTQGNVGILIKPATVTSVNSFPPPQVNTNGNIRWNKSHLPTNEGQYPRYRNEFCPQVFAWICAQPVTFNTNGINILECMQEKWDEILPDVPHRIEPRTAVYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3E6</accession>
    <name>A0A2R6S3E6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3E6"/>
    <dbReference type="STRING" id="98765.A0A2R6S3E6"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="45"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS36804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="152" mass="16738" checksum="1BD3774FCBF94728" modified="2018-06-20" version="1">MLHRFGLATGLRRARDQDLVDAKLRMHAKSHEIPLEEEESSNVDLPLWSLEEAHTYAAAKKGSCLLLIDGNCVDATVYMGEHPGGAALLRKYAVRAAVKTETSEPSSLQATSDTGDSKSWQEATWAFDGGMNQHSSAARRRMQELTVARLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3M4</accession>
    <name>A0A2R6S3M4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3M4"/>
    <dbReference type="STRING" id="98765.A0A2R6S3M4"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF3">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="16054" checksum="1C5E6C6A120445FB" modified="2018-06-20" version="1">MATPPVVKVVPERSVFLICDVQTRFRPAVANFDKVVMTTNKMLKIAKVIGVPIIVTEQNPLALGDTVPEIDLQNLGPLHLGTLEKSLFSMVTPELEGLLRHHNFKSVIIMGIEVMTFTSSRMASQARTKKKFPSRWKECAKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S417</accession>
    <name>A0A2R6S417_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S417"/>
    <dbReference type="STRING" id="98765.A0A2R6S417"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="405" mass="44776" checksum="538E1B4BDAAD0D69" modified="2018-06-20" version="1" fragment="single">DYRGLKKRITAIRRAQERDSEASLLPVSPVVDESESGDATQTELTLAPRTSFLEGHTRISGESGNEGDASNESSPPLSGSLTPREPQDIADSSPPATDEHDPTDSATITKEDTHDPFLNVPKAKSVDAMSIPDLPKREGSTPGPSLFHGATINMGFLPRLKRRSTVRNYWEPSRRAGKSSLQWDLAKSIPLKDLLPLLSPVQRAFFEKLDSEFDKIEAFFVEREKEMRTRTTTLKAQLQELKDHKRAFQEAQSIAPSWLPASLIRRKPTSDPSGTAQTLPRKRRSYKADTGSPMRRRSLVSENKALEEGVENVGPRDIDRLQSSDGTLVNGLINGGGSGSGGSGGDDHERTVGWKRLQHSFQKHNLVKTASAPHTPLLGVTFKHDPEDYQQAKKKLKKAVLECYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S483</accession>
    <name>A0A2R6S483_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Las1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S483"/>
    <dbReference type="STRING" id="98765.A0A2R6S483"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45080" checksum="066D0F6794A5CCB0" modified="2018-06-20" version="1">MRLPRRVPWASIAELDQVCAWIYTDENDLDAKTLAINRISAWKAITTLPHALESTLSILSVIVQDSSEQGSSSYLHIRQSYASAIIRLVNGLVDPLQVGAYARSIASIATQLNLPAWLVELRHAATHEDLPSIEVLREAARDAMAWLLNNYFIPAINPTAPQPLQASPLRPVLPLLMQYKTLLKITTRDASLRSEYRPEITKILRDIERWIAEAKVAADISAATLDWDTSESGDDADDTDGRERWALERFSDALLEKGGLVPVSKNTISSDLPYSTRKRAVSAASFCPSSGITSIWSPLLNHIQVIHPALSSILVSKIISSLFNTDDEDHVAEEEENIALDSGGDAKRDLSYEMCVASWVNWLVSTFGNDNVTENGDNEEKKLKRENAVVALVTNLGPTKTKAVAGDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4F0</accession>
    <name>A0A2R6S4F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4F0"/>
    <dbReference type="STRING" id="98765.A0A2R6S4F0"/>
    <dbReference type="OrthoDB" id="3245657at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015341808" evidence="3">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="386" mass="41135" checksum="10D6E39771B31AAF" modified="2018-06-20" version="1">MFFRCLRTSLLATPILLTPVLAGFVNVTVDDTNPDPFTGAVFDYSPSAWSFGPSCDVCKAKPDQTKAYDGTWHDATYDPTFDPSEPGKSVVQTASLQYNGSALYVYGILSESTSLPSSNANIVFLIDGQPIGKFVYTPPGIAGGYIFNVLLYGNDTIPQGQHTFTIQNGEPGGSPSESLILLDYIIYTRLEDDPVVTSSGSVTSQLESFPQSPQPVSALPSSALPSSTLPSSISHGISHETRDIVVSCITSAVGTALLVLVLFYCLRRRSRSKKAPSSTAVAYPHLVTRAGIEGGIGVHGAVEWKSTPAASLHPLEPNRRRSADGTARDSSFNASQKTWKDHSGYGAATDSSPKAYYYTSSKATDALTNQVMGADESKIEGDSDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4U8</accession>
    <name>A0A2R6S4U8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S4U8"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="716"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1097"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1426"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1426"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1459"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1490"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1517"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1592"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1656"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1684"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1727"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1862"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1981"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1996"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2044"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2114"/>
            <end position="2124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2124" mass="235372" checksum="17B3FDB95A8E3DA9" modified="2018-06-20" version="1">MDVVESVQACVQNWETGGESEWYALITWSPTKALSPQSLTDFIQSVLERLPSPSSAKSSNAVVFGELLVDLIWSIDVDIDEVYQDAKLALANAEQGKTPVVAEGSDPAEVLAKVAQAKKNAEVDKETLGNFVRQLVSLGVLDSNVCRERLELPMISQAGLVLDDHAFGKKEVRARTALFYKQNKFNLLREQSEGYSKLTTELTSRIGPPHSPATGIPVESFSAIEARAKPAWERIVGLVGYFDLDPNRALDIILDVFSVHLMTHYAFFLSLLSFSPWASSPPKTTDTMSMDSLSDPEIYRGRILDDILKLAELQNGKAPRVPQSPASMGANHCRVLAQVLGFKFVYYQAIDVPEQTPKNLYLTAALLIREGFITLEDIYPHITPTDGEMEDNLHKQYLASVASRISGAKVSLLAMAAPLESSSSSNIKTQQTTPAETKSTKPEVKEVPNQKLGLLNALLALGALRPALTMLSKFPWMVDAFPEIADLMLRILKHSIAPVYESYQPEGLYQFRGDVSSFATPRSRYGPSGVTPPSERKPYLTLWAPTPPPTSAADFVFFFPQWTDRIPVCKSIEDIKDVLEPLMRFVGIMVHRDLAFFTRFVRLGRSQLSTVCPDGKKVNGDADPEHPIRRFWFKAARRYMLPSLPLIRGNAVTTVEVWNVLRCYDVTERWRLYGEWRSCYKSHPELRVREVQVDRESKGILRRLSLNTIDSLSGAVAKLAHSNPCIFFSNAVYQIMAYDNLAPVVVQAMKSATLMGFDVMMYAALDALANPNKNRVKDDGVNSSDWLLSLSSFIGLLFTRYSVDLTPILQYIVHQLHNGQTTEIVVLRELIWKMAGIEPLPSLSDSQIAAMGGGPTLRAEAIASSSRGSRSEPGQNKNAPKRLGDALLESQLALPLLIQVAQQRQACVFQAPNAHLKSLASLYDTTHGVLLQYLELLTSPSIVPAQIYAEKVLPSLTELNKAYGICPPICMQIVRPKLHLLLLTAALNMQEKERVASEEAEKRLKAALTAKREPGTTTTSRVGSPAVLDSAASAEQINETSGTAQVNQSTEDVSMEGTELSPAPVPAPAPPENPWLTELYSLFDEVKEIAPGNAADVLGPGFYLTFWQLSTYELSPPTAKYEEESNNLRALYRQEDALYNAADRSSDRIKRATTESHRLKRNRYTDFVNHLSHEMKDQTAVRSFTIKRLAREKHHWFAHGPKALTLASSFIEHCLLPRAVLSPMDADYCAQVIKVIHLLGTPGFSTLRTYDKLLAEDLGVVVFSCSEYEARNYGRFLLGVLTDLWKWHQDEALFMQDNRVKSGGKVTYLPGFLWRFSNKPAVAIGDIISWDQFRTVFKKWHRKIVKCFVECIETGEFMHVYNSIIVLKEILPVFPLAAVNETSGVTLDAAIDRFVEKEERGDLKILGRAYAASLKKREPMWAPPAKIAKSIPSAPSAKSSPVPPQVPDKPRSTIPPSAPNSSVTTDARRTNITLPASTPSAPRAHVNGSGPPSGTQASSTQSPASMKAAIESIPRPEVVKRIRPDNRSPVPKVNGDSENGVNGKADAMNVDALVKPRKDEPATPRGPSGVANGGRPSSPALPSGILPPIPRSISQQFGEASRPNTPGQLSAPRAVPGKDLPGSPRVNNGEPRGARFEASQAMPPPTNPSQTTSAQELRETAKQSRPSDKVEERTRSVSDSRGLPTLPTAPSPSSRRRSPSPSSRPGTRNPSVESRASGGRSRATTNEAERPEEKRSDRDSRHEAREPRGRDGHGRAERSGRANRDNDREKDGDRDRDRGRDSRDRHGDRERGRDRDRGERERDRDREKDRDPRDRDRDHRDRERGDRDRHRRDDKDRDRESRKERESTNRSAAASATATPIADDRGLPSRPDVSRRREEDSLGKRRRPTEDDSDRASKRPSRKESHHEDRSRRLPEKDSHDRPRDSDRRRKDREPSENDSRALSIDTKLADKRIPDGPASARALPPSTPSAPRAMSSNDTSRQKSDREWRGRDQPLRTSPTGPSAVATQSPQEHISSGGSLRSRIGDKEPSRSLPDAPSGYRTESSDRGKPEGSKDESREGSRKRASSERDNADLMQGLGDGGSLASKRPKINRNRYNGSGGMHGLAKKLLPIDADKTRSGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Z8</accession>
    <name>A0A2R6S4Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Z8"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Z8"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14635" checksum="B8F95957318F44DE" modified="2018-06-20" version="1">MSSGTSSSLSEHVASLNLQDRGEDTPAIQSLKSLLRQSLRITILDGRIFLGTFAGTDKQLNILLINTDEFRLAPRQHINPDGRFVGLVLIPWRLVVKVEVHKPQGDDAADADNYRMRGMGNEEENDSLYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5I3</accession>
    <name>A0A2R6S5I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5I3"/>
    <dbReference type="STRING" id="98765.A0A2R6S5I3"/>
    <dbReference type="OrthoDB" id="3225069at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="631" mass="71337" checksum="38767DDC897370FF" modified="2018-06-20" version="1">MPFGDFFRTAGRHQRNCPGDLVNDFQSHPRPPQDFFPFLASRFQRQIHLANTATKQSPASVFVESFNDNAFVARNNRLFTMLTSQRLDIKKIIDELSRQAIELQEYRGSLIQRIRADPSYKHDILDAPLTSDSYWAYQRELGLYQPRLYHPNATVLDMIQKVFVAEASLYRIREKSAELAALIAPIQVIPDEILALIFETVCAPRADANKPYRTKDHRQLPPPILISSVSRKWRRVAYGMPTLWTRILLSPSYPRHWTAMALRRSASERLNVTIDCCTNTCPSSDVLDSLLAVVLPLLNRWRAFTVMSHYSDALRFVGSKLTNLRAPHLRILRLSLTGSGPPGNQAVTIPGVFLGGAPELAHVHVYSVGLLRSSSVLAGLTTIDLRWLWSDMKLSYEQFKGILSASPFLRKLVLRGLYVELIQGMEYPQLSVPSLQCLEVSGDNVSRITALLITPALEELYLANVDETEFREFMQSFESADRAKYPVLRLVHFMNVNTADPTSSFFEAISNIESLTVVHSSASRFLHLLRLHQDAIGGHSNDIILPRLRNLTLLDDASDETLVEVVGQRAAMGYPLHRVNVNAGSVNLHYRTFLERFVKDDKCAFKDGLSHRLIILANHLGTARHPPPLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5M5</accession>
    <name>A0A2R6S5M5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v527</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5M5"/>
    <dbReference type="STRING" id="98765.A0A2R6S5M5"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="114"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="212"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS37600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="302" mass="31481" checksum="8B1209335C21B382" modified="2018-06-20" version="1">MSDAPSVEEVSRTSTTDSIKSFISGGFGGVSAVLVGHPFDLTKTRLQTAAPGTYTGAIDVVKKAVARDGVTGLYRGVVPPLVGVTPIFAVSFWAYDMSKALIYTATPNRTSKELSVAEYATAGFLSAIPSTLVTAPVERAKVLLQVQGQGQGGPQYSGVFDVVKHLYKEGGIRSVYRGSIATVARDGPGSAAYFAAYEVTKGMLTEPGSTDLNLGAVIFAGGMAGVAMWSIAIPPDVIKSRIQSAPTGTYSGFVDCIRKTIAADGITALWKGLGPAMARAFPANAATFLGVEASKKLMDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S623</accession>
    <name>A0A2R6S623_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S623"/>
    <dbReference type="STRING" id="98765.A0A2R6S623"/>
    <dbReference type="OrthoDB" id="3348811at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="303" mass="32645" checksum="9216B195B20C2B7A" modified="2018-06-20" version="1">MLIGPIQHALQHREAAPLDTIPAYVKRANVNSIPAENPTMSLNGNIIPYTASQGQQKRDTNTVPEEIPTKSPNGVITQYVRRANVNTVPAEQPSMSLTGTIIPYSGNQGKPTKRDTNTVPEEIPTKSPNGVITQYARRANVNTVPAEQPSMSLTGTIIPYSGNQGKPTKRDTETVRRANVNTVPAEQPSMSLTGTIIPYSGNQGKPTKRDADIVNRANVNTVPAEQPSMSLTGTIIPYSGNQGKPTKRDTNVVRRADVNSIPAEQPTMSLTGTIVPYSGNQKKRAGIPSEIATRSLNGEIELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S657</accession>
    <name>A0A2R6S657_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000031">
        <property type="protein sequence ID" value="PSS37781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S657"/>
    <dbReference type="STRING" id="98765.A0A2R6S657"/>
    <dbReference type="OrthoDB" id="2758521at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015314792" evidence="3">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="479" mass="50538" checksum="16A49D362025E40A" modified="2018-06-20" version="1">MARQWAIPLFSLLAVISLHTPVSTALVNVTVDDAGTDPNTGSTFVYTPADRWNYGPDCSACTAKPDASLVLDSSWHDATYDPTLGASWNEIQTVSFPFEGSAIYVYGIIARSSDPSQGSADMLFFIDGDQVGSFAQTPSPGDPDNATFTYNALLYNTSSIPNGQHTFALQNGQGQQSSLVLFDYLIYSHDDAALPEPPPPQIPTTSTSTEISSTSAPPITSQTHVSPSPSPGPSSGPSSSEPSSVNTVQSLPPGVSPMPSAHSFTTTPSPTIGPAPSLNLSSSQDQGPPSSLSPSFSSSASTTPVSPADLSSSGNTTSKHTRIIIIACAIVGGVLIIIILASFSLYRRRANVRRRFLEVKPWVSISIPPSSTPELQVDQQTPVHTPLLANFQGRQSKYDDALETQVGYSARNDPSGVSEGSGSSYRPDSTSTLPLQQARVQDNFAMTDDSSDITPADGPPPYSPRHTIRSLSTSSSIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S697</accession>
    <name>A0A2R6S697_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S697"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6011" checksum="C967ED13B3E7674C" modified="2018-06-20" version="1">MSSKYIVVFKKSASQEEVQKYADEVNANGGSVTNVYDSVLKTDSFLNSRACKAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7G1</accession>
    <name>A0A2R6S7G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v46</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7G1"/>
    <dbReference type="STRING" id="98765.A0A2R6S7G1"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36050:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS38139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="576" mass="65204" checksum="90FDAAEA53DD4138" modified="2018-06-20" version="1">MSFYNATAHARQSQASPSVSLEKGAYRLRAPPSKRPSSHLRHRTRDSRASRDGIPPALRYGKQMAVLVMFLICATVACFATAYYLFTTRWDTASPPHSRSGIFSSNDIDLHPPPQVIVDFNVDFNLDSPDGGGSRSLISSGFVDPEERFLAYLPHSGFHNQRIAFENALVLSRLLNRTLLVPPVRLGSKSLSYAPYEALLHMLIKSSKQDLSHCRLHSTPSLYKQELSTPGSDCVDYLNYTYVPWEWLVDLSAVKADQKLLHRWNFKDDWLRDSLELGQEDTFALRDSTRDMYGFQDFISYSNHGGRKYQQMIHLSTLAHRSERLIHLGTLFGSSRLHLRNPSNLLLRKAIRKKMADSNPLLDDIARSIALTIGATYLGAHVRLGDGQFEENAERNVRLVWWKLVHGVLGYSVEQALDMERNFAPDYDTESMAPPELPMDIKSQDSAPKVQFSRVFSYLPCNGRRHTDEHLARLNIPLFISTDSLDRSEDPRLASLVQTFPCTFFLADFAEQIGVLDRLYNAYDGLALKPFLVPLLDAMVVARGTRVVGTEGSTFSCFIEDVLWRVYHKLDIISKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDP7</accession>
    <name>A0A2R6NDP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDP7"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="323" mass="36154" checksum="17942D590E2245CF" modified="2018-06-20" version="1">MVFFRLHESPRYLVHAGRHQEAVQSLQLISKFNGSELSLGLEDVRDHHHPSESSDERARNSVRIFDAQEEFLGSTLGNLSSEGSREVLRSTPPDYSSTGGPDVPLNEHLFITPPPTGASVFYPPIEEALAKAVERPRSPPIVPNPERRTWPTREPSRSRRSSVSEIKSSMYRKLPRWLGRPLWAWTDRIAMVLSPEWLRTTLLMWAIWCSMSLAYTMFNVYLPKLLEGRGNSDGGAEPKPLEESLWDVVIYSIGGCPGAIVRLRVPHTPLLNDSKTNLVGRIPSRLVIRSSLVPGWNAWNCMWDSLGIIANASVLLASGDAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDQ3</accession>
    <name>A0A2R6NDQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v13645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NDQ3"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR70494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18158" checksum="F732F2738BCE6D3E" modified="2018-06-20" version="1">MREVAAALTGLKLTKAYSYLGDVADHKQIIPFRRFAGGVGRASQAKQFKATQGRWPEKSVKFITRLLKNAESNADAKNLDVEDLKIKNIVVQQAPKTRRRTYRAHGRINPYQGHPCHVEIILSATDSEVERSKDKDAVASTSFSGLNRRQVARRRIEAARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDS4</accession>
    <name>A0A2R6NDS4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDS4"/>
    <dbReference type="STRING" id="98765.A0A2R6NDS4"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="15050" checksum="8CB61B07F7B0EFDD" modified="2018-06-20" version="1">MFHSLDRVKALYQGQSELGMANESIAKNNLLLQEPLYQLRSDTKDAFDEAKQLEARWKEVEREQREAYQHATTAQDELSEALASSFVHGAANVTASNGKDVDDFVREFRESRKTYHKRVIWGDRWTAGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEZ8</accession>
    <name>A0A2R6NEZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEZ8"/>
    <dbReference type="OrthoDB" id="2418900at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="827" mass="94703" checksum="DE3E5C844C94CC10" modified="2018-06-20" version="1">MAGIRRHLSHAPACRLRYSSRLSTRYNTRKDQLELQVESHQPLSKVMIDDDLPMDVDMDDSDSLSQAQQDSVLPVLDSDSSGSEQVPNEETEPKSRQARVDDVDDEEPGMLYAQPFPDNRRAGSTYGETKTVFQTIRDDQILEGAEVLGPFRDDEEWELAKWLIKNVGHNQTQSFMNLPIIKNRLDTSFSSKDHLLQRIDHLPQGVEWKCTGLNVKGDLKGQDGVEMSESLELWHRDPVECVRELIGNPAFRDSMQFTPERLYEDELGKREVWNEMWTGKWWWETQMKLPIGATIAPIILSSDKTKLSQFRGDKTAWPVYMTIGNIAKETRRQPSAHSTVLLGYLPVPKLDCCTEKTKKTTRYNLHKGVFHDHLVKWCTVLVGEKELDDRFRSMIPHPNLRHFKNGISSVSQWTGREHKEMEKVFVGLLSGAVEPRVIRAVTALLDFISYASFHSHTSRTLQSLEVALAEFHAHKDVFIELEARYPEHFNIPKVHAMEHYAEMIKTFGSADGYNTEGPERLHIDYAKDAYRASNKRDYIVQMVHWLRRQEAVDRFTAYLDFTRARPADPAPPIESGTLIIQNTDGLAASLSSTAYTRISRHPARELCGITAQQIVDSHQATQFIPALKHYLRVNGCGIVPNQYDTFDLYKRLTIHLPEIAEASKAHCRDVVRAIPPIASKARRAAEPAHMDFALIRVSETNPTMTGTPLAGLRVAHVRALFALPAYFRIRTKTPLAYIEWCTPFRHPHTDNGLYQLHKSTRMHHSHAEIIPVDRIARSCHLVPCFGQIKEPRWTAENVAELCRVFWVNHYFDTHLFAMIKARRRGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFX9</accession>
    <name>A0A2R6NFX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFX9"/>
    <dbReference type="STRING" id="98765.A0A2R6NFX9"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="203"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="297" mass="31818" checksum="6D4FA92A037921E9" modified="2018-06-20" version="1">MSTLRTHSSPDVTISKRRAAVRYANFDPDNPTQAIRKKIEGELSRKRTISTTHQQSRKRGGKSNVQKGTVAALKPSPALTVPENITVSEASQLCAAKRTDCVLVVDDDEGLSGIFTAKDLAYRPVCNEEGNVVGLLDITKVFHEALDKVERSSSASEKLYTALAGVQSELGAGLGANPQAAAMLSYVESLREKTALPDLTTIMDARTLPATVGPKTTVKEVAKLMKEHRTTAVCVMEGTTNAPRIAGIFTSKDVVLRVIAAGLDATRCSVVRVMTPHPDTAAPTTTIHDALKKMHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG15</accession>
    <name>A0A2R6NG15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 13">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 13">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v12838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 13">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 13">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 13">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 13"/>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG15"/>
    <dbReference type="STRING" id="98765.A0A2R6NG15"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 13" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 13" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="158"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR71324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="468" mass="50986" checksum="9BA7987F3505B2CC" modified="2018-06-20" version="1">MNDKGFTVVAYNRTTSKVDSFLANEAKGTNVQGAHSIDELVSKLKTPRKIILLVKAGAAVDAFIDQLVPKLESGDIIIDGGNSHYPDSIRRTKELEAKGLLFVGSGVSGGEEGARYGPSLMPGGSPAAWPHIKEIFQKTAAQVNGEPCCDWVGETGAGHYVKMVHNGIEYGDMQLIAEAYDILKRGLGVSEDEIADIFNKWNKGVLDSFLIDITANILKFKDDDSEPMVSKILDQAGQKGTGKWTAVAALDAGMPVTLIGEAVFARCLSAIKSERVRASKLIAGPQKEAFKGDKQQFIDDLEQALYASKIISYTQGFMLMRETAKEMGWNLNYAGIAQMWRGGCIIKSVFLGDITAAYHKNLELESLLFDDFFNKAVHKAQPGWRRVVAQGVIWGIPLPAFSTALAFFDGYRSEIVPANLLQAQRDYFGAHTFRVLPGKENAKLKAGEDIHINWTGRGGNVSASTYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG50</accession>
    <name>A0A2R6NG50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG50"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31636" checksum="727CBF7D10D1D76E" modified="2018-06-20" version="1">MQEPTCTGIRIRGYRDAEIILHAVRLDILPMIHRRLDDDDRIALRPGHVYVWEERSNNPLEHSSLDAIQRFTDGRSWGPSKAREDFLIYYEKEGTNTKTAMLHRNSGLGNHRLIKQTYSAFVDGPRSTRKWHINAYYTQETHDELRTIDDMSALRDVRVPSGLYLCARSNTQRRTARAVAAHSAFISADPGGDSSDSSLESDSSALSPVFDDTPIRLSMTSSHSPPSDHNRIVASLVNHHDIPPPRRLAPLEYLQNIPPVAREPADDRALRSFRHKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI51</accession>
    <name>A0A2R6NI51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI51"/>
    <dbReference type="STRING" id="98765.A0A2R6NI51"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR71938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="521" mass="56974" checksum="A27920610F903173" modified="2018-06-20" version="1">MKLRDVLLAALQSLPGTREFHIHVLVASPHKHHGLFPYAQPRPRAYLQDILILLSQQATPDAPRVFVTAVEVSVYNIPATSCGILYVSKVDATGQATAPSPTATLIKSLLTYYTNPETRPIHIDTLWIQVFARSQGQYLFPNSSDHSGKRVLTDVKLCAWWKRNLSEVAAETVARNAGVRMKLCYVLPGLSELEALNTLHFAASTPVPSSVQWTYGHQSSQTDIPLPCPPSKGTYNLGHSIPSFDDDPKSRFIDEIAHTTDGDGIRSPEAKRPKSALQQTNSKDRQGEDVDENKEEPRHQGELNKVTPDEFWERMSFRQECIAGAVTGFFWLGIAYPPPPADSHNSSVPSPLAPQPGQVAPRLLKRVVASLLNGYDFSTVERAVRATETLEGVIRGLCENIGSEPAEAKTDPYHLAPLLFQRETTPEPVRSSAVLEVPRTPKKGSKALPEVSPNPFPEPVASLETYESYIYGSISVGNPPLPPRAGAVLGSNGLSGSGKDTPAGKQVTILTVRKKKRKLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NID2</accession>
    <name>A0A2R6NID2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NID2"/>
    <dbReference type="STRING" id="98765.A0A2R6NID2"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="511" mass="54159" checksum="1F17BE099BBB417B" modified="2018-06-20" version="1">MPVPASEVSANVCTCKSTGSCHCCTPRAVVRKRRSKASHNAEDAPLDPDQELPHQPASLVANAHSRDYRPVLPRPTSTNRASPPRSTHSPSGGSHGSRSQIFYSPYERAYEQAHGADIASELQIPPSSFQHQLAQPSPLSTGPLSQGIIPPRDDMSALVSWLSTIQQPSPTTPLNLIGTMCDCGPGCACPGCIVHRGASAHASGLESCSNPTTCNACLECTMQTIVQNPVMDEWLRQLNVNTTVPDANLSNPSSSLSPASSPQSPFVPGPNQPQQQGVSPDLRFDPGMWQTYALWNNLQGQPAVPTPPEDCCGGRCKCPPGMCACPADCCGCCQGCSCTSCLHQDPTMGTGKTLTFALSGERAPCCGGTRSRRAEGETSNHAGPSTSRSAMHGHPSYQNGPALDLRGVYEWDTPSLDVPRVTLSRASSSSSRSSSQHSFPSSSQGSAYTGSPVIPQDSTAVRSCCASMETMDTSFQSHSPVPYPSPATTRLQERTFNSSQFDTDASDSRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIE9</accession>
    <name>A0A2R6NIE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIE9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIE9"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="834"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="935" mass="103827" checksum="44B84FD08C58C819" modified="2018-06-20" version="1">MCFGDNNAPHAIRLFNAQLKAHWENANDCFTHHGSTLKPEDKYKSSFALAKYYYGKHRDGSQASKSDMMFYASFGSPSLVFVCDHEVILRLVIEEGHYNTNFAKASDQSVADRAHNQSLKQVEIDFRVSFTFSTVASRDSAKIGDGLHTYRVLDLHLLQTDLVTTSAPDAKDALEFYFSDYLKLLYSTGQFISLSLPDIDKEGLRTLIDFSLATSSPNALHIDHVCNMSVDRINEFLTRRWLSLSTQTGTSEVSVSDQLMMSIVEYRSTWLTKHFGIHFHVKFNAPRVAALCSQEVILSLYLEEVSFYQSQDLRGEPHRQYSNWEVAILLTATEVKDAAGKGNGIKLNIQGSRVALNLSLFPGFNESDKEAVRYWDGLIQFILTEYLQILDKAQYNMIYGTVTSDPRAGSPDLVKNDDSMEEGESDDLDDETDLEIWKEAADKGDVQPFDQIIAITQSAINLYFQALWEDTTESKSGSLIRTWEYQEYFRSSFSPVSLRLLSNGSAVVWIQIAEGSLKLLKNKTPNNTFNVEKLRVAFEVDVKMCTHADLTDVGTGWQTRFKNSLALKEYSGNNNMTFNYIYLDFKSTTTNIIEIPTTYEREMLKIKLTGSVVFHAEFYNSMQRWSSESSVKWEVCFSLRFNSDGLRVIQESSSPVITKAMVKGEAPKAGSIDPEALLREKWQSNAINVDGVLADLKAFEGPYRSCYPGMFAYTLAQPVFTRKGDLLFQVEPSSPHGNPVVTKPNTHTVPAASGTRKNGSAAPNAHNNTAPIHAAVTTSKATYVPPVTFIPDEDPAKQTNPSAQPSALTKTPASRPLQSPAVAPPPINHPRTEPPAAAPSFPVSSRSAAPPAATPPSPNYPRTERPAATPTPSNYPRTEPLAATPPSPNHPRKEPPPSPRPRTQSTQGNVLPPARNQPARPPSSLNAPHPSNRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIJ9</accession>
    <name>A0A2R6NIJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIJ9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIJ9"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="149" mass="16724" checksum="67CD2D2D32C1C354" modified="2018-06-20" version="1">MDEDPSQDSDQDDEMGFVTASLMKPEQYEKQDKEYLKQKKAQLAALGKWTHINCLRQNARERIQDELLRLLVYVPETDNRSKDDGPPRSRLNSLLAAVDLENVLQATAPPLPVEDLPGGSVSFLFERTSETTTDDDAEALSLASESELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIR0</accession>
    <name>A0A2R6NIR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase UstS-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIR0"/>
    <dbReference type="STRING" id="98765.A0A2R6NIR0"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16763" checksum="FD6D183BE009B454" modified="2018-06-20" version="1">MTREKMFGQTLEDMGGEELWRELEAGLEKLDSWLNANGPGKTILFMGDTITFSDIQIASFLKWANIVCGEDSEDWKRLANLHNGKSWGYLARCRCLMYTSCVQVWHRWSLKFGIVILEKLGKNVYDNNQTGYIISAARESRSVSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ48</accession>
    <name>A0A2R6NJ48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="9" type="ORF">PHLCEN_2v11769</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001193">
        <property type="protein sequence ID" value="PSR72363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ48"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ48"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR72363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="216" mass="24754" checksum="4F3F11B29516E77D" modified="2018-06-20" version="1">MVAAVGDLTSGPVLPTLRDRMLASPEGRRILKERPRINTKTVDMQKLALLPEGTVGHAYVKWLERCGVTPDTREPVHYIEDPELAYVLQRYRECHDFYHCIVNLPVDVTSELAVKFFEFANLGLPMAGFAAAFGHLRLSSSKRERLFKEYVPWAIKCGSTSQSLITVYWEERWSQNMDELKKELGLWDAPETKWRNPSNEAKAAAARKQKETEFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJE5</accession>
    <name>A0A2R6NJE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001175">
        <property type="protein sequence ID" value="PSR72476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJE5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="10522" checksum="875FB6709C2E2E60" modified="2018-06-20" version="1">MANPVGIIAFGVHAIHKVYDVYQKIKSAPEEIYALQEDAAILEGILPKIKEALLKETDSGPVTVLVSKAQELIASVKKSIKAVTKAVEGRQKVKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJW8</accession>
    <name>A0A2R6NJW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001142">
        <property type="protein sequence ID" value="PSR72674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJW8"/>
    <dbReference type="STRING" id="98765.A0A2R6NJW8"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="13104" checksum="E9BB641E48746CBD" modified="2018-06-20" version="1" fragment="single">MSRRLQKELRDLQTQGTPVGIELLNAEDFETWILSIEILGDTIYSGELFALQFRFDAQYPISSPSVTFVVNDKFQAPVHPHVYSNGHICASILGSDWSPVLTVSAVCITLQSMLASCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJX5</accession>
    <name>A0A2R6NJX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v11541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJX5"/>
    <dbReference type="STRING" id="98765.A0A2R6NJX5"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="206"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="514"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="695"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR72548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1170" mass="131510" checksum="718868020B611EEF" modified="2018-06-20" version="1">MSNADLYNLEFLSLVAKITQEIVNHTGLNDKTLAEFVIALHEESRTLSEFKQKLKDVGANFPESFVENVDRLILNMHPKHKKKNAVFRENASNGEVIIDELDKQKRMFPGLALKDQEWQPSVAKDVLMKEVDDMMSQFEGAAKKVKARPMESDSQRSPKRQRRSQSPPMRRRSPSPPRGRGYGDQRVDGRGRGRGKASIDEKPILYKIYNGRVSGMKEFGAFVQVEGVNGRVEGMVHVSNIQQGARANSAADLLSRGQNVKVKVMSVVGNRIGLSMKDVDQISGRDLTPHLRIKSEAELAEEEAQRAARGANAVPLNSKDFRDEPVVRSAKRLTSPERWEIKQLISSGIVDASEYPDLDEDFSNPMARAEIEEELDVEIREEEPPFLAGQTKKTLDLSPVKIVKAPDGSLNRAALAGASLAKERRELRQQEVNEQADSEARDFSAPWLDPMSKESDKIFAQDLRGNLRGQKAGEQPKWKDAAFNKATTFGEITSLSIQDQRKNLPIYKLRDPLLQAIREHQVLIVVGDTGSGKTTQMTQYLAEDGFADKGRIGCTQPRRVAAMSVAKRVAEEVGCRLGQEVGYTIRFEDCTSPETRIKYMTDGMLQRECLIDPDVTQYSVIMLDEAHERTIATDVLFGLLKKAIKRRPDLKLIVTSATLDAEKFSKYFFGCPIFTIPGRTYPVEVLYTKEPETDYLDASLITVMQIHLSEPPGDVLLFLTGQEEIDTTCEILYERMKALGPKVPELMILPIYSALPSEVQSRVFEPTPPGARKVVVATNVAETSLTIPGIYYVIDPGFSKQNAYDPRLGMDSLVVMPISQAQARQRAGRAGRTGPGKCYRLYTEAAFRNEMLPNSIPDIQRTNLASTILTLKAMGVNDLLSFDFMDPPPAQTMLTALESLYALSALDDEGLLTRLGRKMADFPMDPPLAKMLIASVDFGCSDEILSIVAMLSVQSVFYRPKEKQGQADSKKAKFHQPEGDHLTLLTVYNGWKASSFSNPWCYENFIQARSMRRAQDVRKQLLGIMDRYKHDIVSAGKDFNLVRRAICSGFFRHAAKKDPQEGYKTLVEGTPVYIHPSSALFNRNPEWIIYHELILTTREYCHNVTAIEPKWLVDVAPQFFKVADANKISKRKKQEKIEPLFNKYEKPDEWRLSKVKRSARSVARLPICSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJY7</accession>
    <name>A0A2R6NJY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJY7"/>
    <dbReference type="OrthoDB" id="3270985at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="340" mass="33657" checksum="3D1DF954F4835828" modified="2018-06-20" version="1">MRMPSSSSFILATLASSTSLSSLVAAAPTEAQDPSAVSATSSNEAPNPGAGGLPDVLGTFTGALRAFSSFHILRVGLTMERATAGMRREIEARQLGPVLDTVAGALPVVDTVLGLLGLKRVDDMSTQSVLPDTQVKNIEVALQQLTKGLPIPLPLPALPLSAPVGNTARADRNWAHESNSGFVPFVMDATPASSTSSCATPTSSTSAIFAAAAPPAGAPNLPAGLPGLPPLPVTLPPLPVALPSVPGVIPSVPAGLPSLPIALPAPFSPALPANPPNTPNPPASPAPPAGGSAQAAGIPALGVPPLFGSVPGFNAAGVNETSSMTTGMSSSSMPSATKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKA9</accession>
    <name>A0A2R6NKA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CNH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NKA9"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="648"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1397" mass="155924" checksum="23A9CAB194674196" modified="2018-06-20" version="1">MEKPLGPRAPPDKRTTAYQSIFGRPSATHHQQQQPAPAQYAQPPYPYSSPNGQHGAQVDRRPSHTSSRAPSVSYSQQAPANVYRQSYYPTQSPQSYISPPQPPPQYTQMNNLTPGTPSMMSRARSMGRTAGIIAPAPEEPPDPSLEALTRAGLTPAQAYQAQVYMNRPMGQSTSQSSPQQFPRPSVDRQPPPNNLPQLGLNIDTDDGKLGIDFLGGETPSDHSTDSSNELQWSQQLPRSHPNSVRSRISVVSGFAPIAEQLDQPFASTSSRPYPLQLDTAVSAAHVTGASTSPASSTLAESSGVSSVPSSTVATTSGRRSSESSRTLPGPFRRDRAAQDRSRSMSATITPQVRAMLESGMRVPRPPVPAAGSGVRDSSGSKPNRRVPIVYPALLSRVAQALKERIPLNDHLKDGLTYKDAFDGREAVDKIAYIIKTTDRNLALLLGRALDAQKFFHAVTYDHRLRDSSHDIYQFRTKVPSPFVSGELVDADGDSIKDAVVKAPAHPLMNDGQSGEAKVVLKDSPTQSVESSAEKVHRDGSPSPPDSVTSPMTRPRQGSISSDDIPLPSGVFTLLTDCYSPTCTRDQLCYSIACPRRMEQQARLNMKPQPGLKKQISRESLGDLVEPGTLWIHSVPQAIVDSVSDAEKRRQEAINEVIYTERDFVRDMEYLRDLWIKPLRESDIIPEPRRTQFLDQVFWNILDIIAVNTRLRDALNKRQKSYAVVEQIGDILLDAVPHFGPFVSYGAHQLYGKYEFEKEKSSNPAFAQFVEETERRPESRKLELNGYLTKPTTRLARYPLLLGAVLKQTPDDSPDKTELPKVVEIVKGFLNEVNTETGKAENRFNLLQLHQQLVFRQGEEVVDLRLPEEGRELVYKGPLKKRGGSQGDSAELIVFLFDHALLMVKQKSKLEQYKVYRRPIPLELLLVSAPDEYPTAKPANARQKALLLKNMPHAPVIPVKESKGGFSITFVHLGRKYYQMTLWASTYVGQRKWVEHILKQQEIMRDRCQIFETVTLSEGFFVGPNRINCAAPFDQGRRAVYGTADGVYLSNLWENREPTKVLALLDVTQIDVLEDYQLLIVLSEGQVLTVPLEALDPRDPLAALRRAKRIASHISFFKAGVCLGKRLVCVVKASALSSTIKALEPIDQNVRGRSKPTFRKLIQGGNDTLRSFKEFYIPVQSNSIHFLKTRLCVGCTNGFEIVDLETLDTQGLLDPADLSLDFARKREGLRPLAIFRIDNEFLLCYDEFAFYVNKTGWRSRKDFMVYWEGVPTGFALQFPYVLAFEPTFVEIRHVQTGAMSQIIQGNNLRCLFADTPPTNSAANAQFNPYQQAYPQSVNPYARQSMQSVQSLQSSHNGYAAQYSNPYQPRPTTYGRDEILMVSDDRIMRLQIRIPPLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKD4</accession>
    <name>A0A2R6NKD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001135">
        <property type="protein sequence ID" value="PSR72786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKD4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="11748" checksum="64AA2EE90C46E738" modified="2018-06-20" version="1">MHEYKVGLEPSGGSCESLSASTCEGANTDYPAAWRVFVGKESSALSLGLGKYFSKEFRTTLLRTLQCGNSSLPPGRRGDGRLLVVYPTACSYRRSPVREFGATMVIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKL7</accession>
    <name>A0A2R6NKL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7605 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKL7"/>
    <dbReference type="STRING" id="98765.A0A2R6NKL7"/>
    <dbReference type="OrthoDB" id="2804455at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7605" evidence="1">
        <location>
            <begin position="167"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="415" mass="47459" checksum="2860C1565419A008" modified="2018-06-20" version="1">MAEDGESQTFSRIEETKIPVLRDYLMRLAQPRSDAGIDVLKRCVDTLHKSSSQYLDTANVDEQHRIQKERMLKRWDSQSFTKAESLQHTAAVPSSQVPQLEETELRFDETIYPRLKKEFCKAVDVAASDVDEWFQSRLKTITTRAAQRAEKAVPRVLEVFLEGIRWWSTINAILRRDGEYCEHNINEVLLEPYLRCLASSYISIFEKDLFKTLKKDILAVVNSLLQDVEHSVAECASIKEDTIWRCSIVRQLTQDCLVAVGDAVEDILDAKRQEVSSTLEPQIQTKMRPAYVQALGEKGRGSFNRKKVILQDFVKKHLHDLYRGNAKVLSEGFANAAGLIKDMLEERLDLLAEEVCELGLPPTCYIVMLKYNVKLETTLTNGWQSPRNDPGEQEREAGLRTLLESSQRYALTMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL43</accession>
    <name>A0A2R6NL43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001107">
        <property type="protein sequence ID" value="PSR73097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL43"/>
    <dbReference type="STRING" id="98765.A0A2R6NL43"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000018">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="204" mass="23032" checksum="817B38CBA130143B" modified="2018-06-20" version="1">MSEPLDALAPRGEEEHDPHFEPVIRLTQQVETKTYEEDEDVLFKMRAKLFRFASDSAEWKERGTGDVRLLQSKETKKIRLVMRRDKTLKVCANHTISADMKLQPNIGSDRSWVWKVLADYAETPATPETLAIRFANAENAGQFKEAFEKAQKSNASISSSSEEPVAEVAVEASSTETEEAKVDKPDDDVPTTDEVKAEEEKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLE0</accession>
    <name>A0A2R6NLE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLE0"/>
    <dbReference type="STRING" id="98765.A0A2R6NLE0"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9944" checksum="3351C37787C09BE7" modified="2018-06-20" version="1">MNLPDVSTLKLDDPGPGPGTTSPTIPDDIAQSTDHYMTKLRNYCKSIPYSVESNARMQEMLDLILLRIAQSVEAKDYDPGLQQWDSMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLF6</accession>
    <name>A0A2R6NLF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLF6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6238" checksum="7A41068AA41361A7" modified="2018-06-20" version="1">MNGVYGVKISVVETKIWTNDSRAKLVVHRGPAEGSRANGRREGPANVKLEGEKVATGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NME7</accession>
    <name>A0A2R6NME7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NME7"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10979" checksum="864A1588F5A77D8B" modified="2018-06-20" version="1">MDMGYSGYDTYNNQVGFPISRRQSMYSHPGVGGDYGYDQQMGAGVYGEVSIIFHNPSENLSDATSFQNYPQPAYPIYTPSRQLSQYTPARECLSKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN94</accession>
    <name>A0A2R6NN94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001052">
        <property type="protein sequence ID" value="PSR73878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN94"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="24828" checksum="0573EE7930AF3DAF" modified="2018-06-20" version="1">MLCVGFRSRPVTRVPRSSIVPPGLAFVFMVHLPSLLANIPHITHLDPDERLGPIDFPWNTWGPTSTRYFKVADNDHYTFNQLHFPSNGTHVLLGNLLLDFNQLDIARDISHVLSRQTTGHGTIFKRSPLVNNTSFKQGKAKNIRVPEYPGRIVRCPTVIPRGWMFKEEVITALPYRETSIPTPFKPGSLESFACHTRVASVIPHFKVESPHQTHRILHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPN3</accession>
    <name>A0A2R6NPN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPN3"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29380" checksum="5C7BD89A9B039565" modified="2018-06-20" version="1">MDQTSSTARLVESYVIVQVSPSYPESRACADLWSTQYNALLELASNRSNIYSPLWHGPPATALTPQGQLAALDTLNSAAGLGAPVLLSSSTTTTTHLSSSATSSSSPTVASTAPQSQNKTFGSGFSKVKMLLIVVLSIVVFLLLATSLLSLRRRHRRQSVSGATSTETRILVVPSRQSPNMPQPEHPVVSRPTSIWKTPESLVGEEIDISSVVEERGSIVFSEDVETGRPRTVDIMDPPYPSSMPRLIRQLKEMLARTPPENIDEPPPYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPT8</accession>
    <name>A0A2R6NPT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin-like protein 4A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPT8"/>
    <dbReference type="STRING" id="98765.A0A2R6NPT8"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8366" checksum="4470CF48A2438E1A" modified="2018-06-20" version="1">MSYFLPHLPSGWHVDEAIKSEEDRVVVLRFGHDWDSQCMTMDETLHGVAEKVQNFAVIYLVDITEVPDFNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRD9</accession>
    <name>A0A2R6NRD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000917">
        <property type="protein sequence ID" value="PSR75220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRD9"/>
    <dbReference type="STRING" id="98765.A0A2R6NRD9"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="347" mass="37150" checksum="9F97320C684ABBAD" modified="2018-06-20" version="1">MADANTIYYDDTSNQIHHSSGPWYPLIRNYSDVYNGTISGVNDVAVFTFTFFGSRVYVYGGLRGMNYTLPEPTESTYSIDNVVKQNYIAPQVKVDDYGVMFFDSGDIGALNHFMLVNITSATASFPYYLDSIAVVSPPNASTTSSQSLTPSHSVTPVPSGQHPASGPIAGGVVGGVSLISLLAAIFFWYRRRKSRSLRERVNIHEDKFNPNNIEGAGIGQVVPFILPQRYGVSLNPTKSGNPPLTQFQNNSSSPQSPGSSRSSSAPALPYVYDSKAYWVPSTEHVIADRQSGSSTDIARSGGTQSSLPVPPHLVGIASNLGLGLSGDTEGNEGIAQIAELPPAYTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRE5</accession>
    <name>A0A2R6NRE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRE5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="15567" checksum="5ADFCEC83CB0F6C0" modified="2018-06-20" version="1">MANGVRSRNRVRKEQEQLDDANRVLGKPVFLPTTNEYIPLILCILLSDSNRTSSGQGQGWGSSSMLVGLLHDQLQDCAADKTHGEKSAAMAMTSSRKATTISAGKRARAVESESGRDVAKDNNKAKSKKAKGELPMCTLLVVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRW7</accession>
    <name>A0A2R6NRW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRW7"/>
    <dbReference type="STRING" id="98765.A0A2R6NRW7"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="376" mass="39553" checksum="B4858709EF75B8B7" modified="2018-06-20" version="1">MNSHQRRRSLSSSSSSSDDDHRHRREEKKHKAEQGYVGTGHSAAAAGIPVGVPSTHLSNDLLTRTQPTAQQRSTMSGPGFPDASSPPPYHYGAPSYAGGSQGFVDMPNASSSPHFAPPPGPPPFPLSPSEGPAFPAPRGEPGFPSPHSPDFPSAHGDAGFLPPAAPGSVIGAPDFPSPPTEFPSSPTSRGIGETTHDRGFHIPGFPSHHQSSPPPPTPQAHGGLPPPSGFRVPLDTNAAFPSYQAGQPIGYDADGRSPIFIGSALLEKSVHPCKIVPSLTPACRVPYGGTEYEHHGRYDLLPFDPATMEWVHTSQGRIPAGRRPVEGGYEDYGEKLYHALALFSGVQVPGKTGEHLGGCNIAFGGGEHVVQDYQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS03</accession>
    <name>A0A2R6NS03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v8936</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS03"/>
    <dbReference type="STRING" id="98765.A0A2R6NS03"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="97"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="312"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR75645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="417" mass="46636" checksum="7D7E78F4883720A2" modified="2018-06-20" version="1">MAIESKIVVQNPVVELDGDEMTRIIWKKIREELILPYVQLDIKYYDLGVEYRDATNDKVTIDSAEAILKYGVGIKCATITPDEARVEEFKLKEMWKSPNGTIRNILGGTVFREPIILKSIPKPVPGWTKPIVIGRHAFGDQYRSTDFVAPGPGTVELIYTPADGGKPTALKVYDFKGKGVAMAMYNTDESITGFAHSSFKMALSKKLPLFMSTKNTILKKYDGRFKDIFQEIYDTQYKKAFEDAGIYYEHRLIDDMVAQAIKSSGGFVWACKNYDGDVQSDILAQGFGSLGMMTSELVTPDGKTIESEAAHGTVTRHYREWQKGNETSTNPVASIFAWTRGLLFRAKLDGNDALRDFCLDLEAACVEVIDVDGIMTKDLALAIHGKNMKREHWVVTDAYMDAVNAKLKEKMAARKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSQ7</accession>
    <name>A0A2R6NSQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000870">
        <property type="protein sequence ID" value="PSR75975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSQ7"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="211" mass="23848" checksum="D863D9441CFA6C0A" modified="2018-06-20" version="1">MTKAAAIAILKEWEMAGITTEDDRITYIQANLKLDFKCMISDPENLRGMFESSVILQTFAIHLSSTAGSLIRYGNPVGRLALAVAAVERGFVLWKTGHILSKNKLAARIKICATEDERKRAKKSNACLIYFSQATWGRTTRQYMWNLTKKMWKAIIFKVQVYKRAAKNCKDLESDGFESNQDVRALLIVANPDDNDNDYNGGDDNEEELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSX8</accession>
    <name>A0A2R6NSX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v8685</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000862">
        <property type="protein sequence ID" value="PSR76097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSX8"/>
    <dbReference type="STRING" id="98765.A0A2R6NSX8"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="314"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR76097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="725" mass="81333" checksum="2F87200966A90FE6" modified="2018-06-20" version="1">MTTVVTISLSSSPDKTDETQRHSDAPVSSNSYLSATHSPSSRSSSEVYKEYGVDSTIHAANGSLVECSIHRVGTGSPISNGLVHSDSTDSKIGPPPPSPPASIAGSPALDLDGSPNSWQSMQSQPSSNTRPVTFEDPVLRRPSSSSSRKLSTRLPPSIGRRSSVDTESSNRETSPTTPRITHTLTDQSDGIIDLSLSEEILEDGLLRAPHPKNSRRNTIGSAGPLPSTSSQVSRAKSLHFPAQDAETDGELASDIQQQAQQIRKERLSKKAKAAVEAEMTKVDQGAERALTRTTSVVRRDEGPLVGNLIGEGHANYVLMFNMLTGIRVAVSRCQAKIRRPLTEEDYTAAHKYSFDFAGNELTPSTKYDFKFKDYAPWVFRELREEYFHLDPADYLLSLTAKYILSELGSPGKSGSFFYFSRDYRFIIKTIHYTEHKFLRRILRQYHEHVTSNPHTLLSRFYGLHRVKLPHGRKIHFVIMNNLFPPHKDVHETYDLKGSTIGREYPEEKAAQNPRAVLKDLNWINRGKELELGPEKRALLAEQIRRDSALLKHIDVMDYSLLIGIHNMARGNRDNVRRNTLKVFSPEVKRLRRKLTLGKGKGPLSPEAAEMRRVVRESDPQILDPSDILPDEDTGERQHFLFYQDEGGLRATDEANDSLNKIYYLGIIDILTPYTTLKKLEHFWKGLKADRHKISPVPPVEYADRFFSFMKAIMRGGEGGSRFKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT82</accession>
    <name>A0A2R6NT82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT82"/>
    <dbReference type="STRING" id="98765.A0A2R6NT82"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="150" mass="16231" checksum="54D7F3BFD769EEEB" modified="2018-06-20" version="1">MILRRITGLSKLALISWSKELQRRLVAEDIPIIVTSLNPGGVHTDGNKAFAAQQNFVVKNLFLLLSYSAFPSPTKGAYPSIIAAASPEVRANSKAYMGAYLEPSGKIGKSNSPTADCCNEELSQELWTTTEGILKDIGVLEGDHLQIVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTV3</accession>
    <name>A0A2R6NTV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere replication protein EST3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTV3"/>
    <dbReference type="OrthoDB" id="3144405at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="111635" checksum="28115D402499FB22" modified="2018-06-20" version="1">MSGSLSQPWIQAYLLDIATTYGGDLSSIPISPHGKKVQLVKFITHEIPGEDAWIWALVSDQAHKLPVRFSKEAMRQHRQDPLFGSRPISDYKTVVMQIKQFRPMFTRIPRGVGQQGMHSYPQLALEVCFFQLKGSMGEPPWGKPKDVETHEDIRAWSEGLKAGGGGGNVLKLRKLEREQEENAAEQGVEDDPPERIVVHKQVESKGGSSSRMHQNGLRENRVKSKAGRNRKVFKTKPVVVTDEMYRVISTLQRTGIYAEPDALSLSTPESSPIRSPQIARAEDQSLPSTPSRLEVRPTTPSHWTPSVYGGTQQAQSPPLPISLADDGPGHHLESIHEYDIGDLDQEYPSVIDGLAHEETPGADQELSPDANDDADMAEPEAPVEESIERAEVAEVQYLEGRVEQRTIEDSQKSYDTHISKSSDLPAPTPAQRTKLLPFSPLLQTLYSASIPQPSSSAMPTFPLMSSAPDQSPLYVPDSSPGRSPSIGLSGVVIQRGRNVSGDVSAYGRILVPDSDISMSQSQSQSQPQLSQVPVVVPQVESQSQSQSEGYARTAQSLSYTSVSQNAGKSQNSQPQTANQPPESGHAPDQAADQVVPSGGAVGPDDNRVDVEVVKDDAPTGTTSHSTAHHSPVVAHENPVQVNALSTRSPVLGSRERTIDLTAESEEESEFDHDLDLGNVHVSPEHWSLGSGSEVDELDSDDARTDAMVCKHDIFTTGRPQKAHINHVAVPVTYHDAESWRAPSFMAGRSSSIAASIAGSSHKQKSPERTAVNKRVLPSHSDEDDRPAKKRKKTLRSPVSIESSTEPPVAPPNRRPSSAVRSKSPRSIPAKQSASSSITLEKTDSLGSTVSKVKHIDLHHTKSASPALSHGLPVKTYARYSSGSTASSSKNVGPTRGDPEVVKDAGKGTRHINVRTSGSASSLVEGEGTSRRHSAKGKERMQSLSVTNSEVAMEPSLAEMSRSRDDSLRTSSRPKLGGYKLDLRLKRGESSDLPLVTWEALTEVLLKTGRARHKEQLRRKELDSELNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUD4</accession>
    <name>A0A2R6NUD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v8171</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUD4"/>
    <dbReference type="STRING" id="98765.A0A2R6NUD4"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR76790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="15823" checksum="83C4DED32E11C413" modified="2018-06-20" version="1">MPSPSKSGGKSKGGASSIADHNQPQQRTLQTRSQRAGLQFPVGRIHRYLKQRTQHNVRIGAKAAVYTSAILEYLTAEVLELAGNASKDLRVKRITPRHLQLAIRGDEELDTLVRATIAGGGVLPFIHKSLTQQQKGKKPDGQPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUH0</accession>
    <name>A0A2R6NUH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000826">
        <property type="protein sequence ID" value="PSR76903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUH0"/>
    <dbReference type="STRING" id="98765.A0A2R6NUH0"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115349" checksum="38C9201FCD00EB4C" modified="2018-06-20" version="1">MPAQRRKQTYKPRVLPCTFKGCRQLFTNNSGLKRHVSSAHQDFGAGLRLHPLTGAAASKDLGFYAGSMPAADGPDLDWVEAGGGSDELWDPPPAHVEHVEADSDQIGGGHDRKHVEIHSLLDGIPCDLNGDDLPPGTSPLVQSQAPVDDYSPFMDRSEFELADFFYRKVQMSGGRIDELMQLWGSRDPNPPFADHRDLYNCIDAISVGDIPWQTFSVSYKGARSVNAAGEVPGWMDSKYEVHFRCPRKILQNQIGNPDFAGEMDFAPKRVFGKGGKRQYCDFMSGNWAWNQADIIATEDASTHGATFCPIIAGSDKTTVSVATGQNEYYPLYISNGLVHNNVRRAHRNAVTLVAFLAVPKTDREHDDNAKFRKFRRQLFHTSLNFIFQSLKPGMTTPEVTLCSDGHYRRIIYGLGPYIADYPEQVLLSCVVQGWCPKCMARPDELHSSGTRRTHKHTRQLLDSFDLNTLWDDYGVVGDLVPFTVGFPRADIHELLSPDILHQVIKGTFKDHLVAWVGEYLGLVHGPTRAAAIMADIDRRIAAVPSFPGLRRFPEGRGFKQWTGDDSKALMKVYLPALAGHVPSQMLQALSAFMDFCYLVRRDVISEDTLVAIDVALEQFQRERIVFEESGVQTSGFSLPRQHSILHYRKNIQLFAAPNGLCSSITEAKHIKAVKEPWRRSSRFEALGQMLVTNARLDKLSAARVDFEARGMLVGPCSILPATTALVGVGVDLSEGPEIPEQPSGFDKAKAKEMVLIAAEDDDGGPAEDGVTAQVTLAKCPARGYPGQLEALAEYIQVPQLTELTRRFLYDELNPGYSSSQITSDHYPDIISHISVFPSAIATYYAPSDYSGIGGMHRERIRAVPLWRREGPRHDCVFLDRDPTLPGFRGLDVVRVLLFFSFKFQQVRYPFYIQLLQHFLRYEQLLAYQEQWEQAWALSNEDPSKHNGIINPLPGQQGLHNGEDVLRDDGSYYMGGVNNGAGIDEVHEVHLRAMLDRDEPIVSEGQREFRLPELVVEMSDDEEELANDHMYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUS1</accession>
    <name>A0A2R6NUS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUS1"/>
    <dbReference type="OrthoDB" id="10620916at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="128" mass="13995" checksum="36EFDF8D1D8CF151" modified="2018-06-20" version="1">MSGSRSSVERLFSPPAASDVEMLQSDAPGPSDSSFHGPSSPSESPLSPLPESPPRLFVELPLLSPTSKSKYTTDFSERVTMLEEAYPEREMDSIIGEYSFGRKSSYFVKLSTGLAVKVSILARSQRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUT6</accession>
    <name>A0A2R6NUT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000812">
        <property type="protein sequence ID" value="PSR77140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUT6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6648" checksum="4058E49D3319F545" modified="2018-06-20" version="1">MDFTIDTGESCITKTSPTDDIIFSPVEIDQLVSELDKIGVEGSDSLFEDILKNLKGEGILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUW9</accession>
    <name>A0A2R6NUW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000809">
        <property type="protein sequence ID" value="PSR77192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUW9"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="5825" checksum="1B7940486A3C1CD1" modified="2018-06-20" version="1">MGVAGQLAQKSVRVAKTYTKGYSSTQKKVRSATSNDLSPPTSREMNDIAVLSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV91</accession>
    <name>A0A2R6NV91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000817">
        <property type="protein sequence ID" value="PSR77028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV91"/>
    <dbReference type="OrthoDB" id="3149405at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="263"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="495" mass="56359" checksum="7BE502D5F8053778" modified="2018-06-20" version="1">MDKVAELPYKGKRDRASLLAWEDAWQKTLDDLYSEKKTFPQLTPSDAPLPCDLKLELDVDLRAAEVYALQFDVSEEIVKSMAMEDFEKHWLNTPAVHREAFILHGIAITAKGRKEIEPWRRWCPDGTLKAFAADDGRGFLELLRPFMLQDFTSISDSVEPVDIPHPIIDEILSLSKEDTENPSFILPVRHVRVERACLLTLFIQNTIRAFYGKPPSLLYSDPSSDESSAASEVEKAEKKLEEATKYHDGLKMMMATLIPCWHCGVCPREKADGSKLFICSPCKKIGRKIRYCSKTCQMNDWKGGKPPHESVCGNPDADPGTGSEGVFSPSFWKSLKAIDEPYRGCIPSESHELETTPALEHQLALLKSSPYPDYVLIDQESGIETSIHMNHFDMDMEALTKRDWETVNDLFYFISLVFKGHKFSIQQVREQLEREYGVSVLEEPLGKFGPDPTDDEWLSVESVIYIDTARLHDLQENVKFVNDMATNMKRDLGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVL7</accession>
    <name>A0A2R6NVL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phospholipase A-2-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v7823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVL7"/>
    <dbReference type="STRING" id="98765.A0A2R6NVL7"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="302"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="474"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR77633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="72565" checksum="185E23EEB6321FF4" modified="2018-06-20" version="1">MNYKLSATLSAHTIAKRGGKGYVVTGGQDAVINIFSLATHKEEPNFSLVGHTQNVCSLDAAPDGTVISGSWDQTAKIWKNFELAYDLVGHSQSVWAVLAIDPERFLTGSADNTIKLWYQHKNVKTFTGHTQAVRGLALIPDIGFASCSNDSEIRVWAMEGDAIYTLSGHTSFVYSISVLPSGDIVSGGEDRTLRIWRDGECAQVITHPAISVWTVSTMPNADIVTGCSDGVVRVFSASEERWAPANELKAYEDSVASTALPAQQVGDVKKSDLPGIEALSQPGKKAGEVKMIRNGESVEAHEWDSVNFSWKKIGDVVDAVGSGRKQLYQGKEYDYVFDVDVEEGSPPLKLPYNANENPYTAAQRFLDNHELPHSYLDEVVRFIEKNTAGVNIGSGGGEFVDPFTGASRYQASQTTSTGGSQDYMDPFTGASRYRAPPASAPPVVASSDPWTGGSRYSGSSAPPTPAQSTSAASVGLPVRGTLSFRQANVSAMQAKLYQFDQALSNEISTSALSMYHQELNYIEETFLYLSQAVANSTITSPPITNKHVDAIIALLERWPSGTRFPVVDLSRLIIGYCEPAYADPETRKQFFTTLFQAAEWNEPWSSPLPKSRDTNVLLLLRGLANAFQDDTTLDNGAWAGHILEKLGEAPYTVLSKNQRVALGTILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVW2</accession>
    <name>A0A2R6NVW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000779">
        <property type="protein sequence ID" value="PSR77734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVW2"/>
    <dbReference type="OrthoDB" id="10681046at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="19823" checksum="2DACE17D2CA969D2" modified="2018-06-20" version="1">MSSVHPRTLEAVPKEFRSFYHPSIRRIYLSGVPIDPDEEEAVEKIQKELELESLRASVSQAHEREHATQSQVRSLWNSWTQEKTKNAELQQQLAAAIERERVAKEELRRYEAELRLKRENHSLPSMSSQDPHLGSMFDFQDNDSGYLGVTGAPSYQGFQHWASLASQNNFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXD5</accession>
    <name>A0A2R6NXD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXD5"/>
    <dbReference type="STRING" id="98765.A0A2R6NXD5"/>
    <dbReference type="OrthoDB" id="3256408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="641" mass="71002" checksum="2E560B723A5BD009" modified="2018-06-20" version="1">MSTTVRSHDSRLPTPVDPWCSRQLVYSEGDSESLEVFVPLDFGDRKSQTLFDQSVYLLDNYPSPRFSETALKASVHLPYFDSESVMESSEFGDRSFLPRLLTGSHETFYGPQPPSPPLETPELVQRSLPNVREPLLPPPNPPIDTQELSQETVSASDTCAPSGSRLCPRSRDEEGTTPSKRQCRRFVAKHNSVVGNVTPRPGSCKSSENFQAAVLMTPGTPSSTWSTSATSSSVYSPLGPGDLMEDAPDMLFEDDLMDWNGDSSHCGSSSITSSPKPRSLSLDLPKFDGFGPSSSTGWPPRSYTDPDSSWPLAPLWEPMQTGDFMTEPLSPHPSPLNLPGTDLESDEYLEQPMSFYDPPPPSIPSSPSRRQLQSLPSLYDDLSIAPHSPRTFTTRLPELEMEDPDRPHVSLDFGASELFTGETNPFVSPPTISPSLLEPGRSDPEGLGLFIHPSSIDPPLDRSPSPDDDDLQFLDIQLDPTFTHLPLDEFLRLRALRRRALDAEREARSLETNLAERVSYASNALLPSEGLVDPIEKRARKNELHVATEMRAEARKERKREKQRSKELGALLDLKMEKCSLQGRGAMQSMAQLVANMLLRRRDTFRLLAQRKTASSGRSSGFSPLRVSVSAEDLLADDFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXF9</accession>
    <name>A0A2R6NXF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000711">
        <property type="protein sequence ID" value="PSR79078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXF9"/>
    <dbReference type="STRING" id="98765.A0A2R6NXF9"/>
    <dbReference type="OrthoDB" id="2796020at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="59"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="36736" checksum="2DFB653ADD795CED" modified="2018-06-20" version="1">MAQASQEKNSTTPTTFYPPTLSTQVGNNPGNMKEALAHPDSQQWMLAMVEEITRLEARNSWEYVYPPTNANLISARFVYNLKGDPTRYRARLVPQGYKQVKGLDYNFDDIFAPVTRLKSVCAMCAIAAIENDELVQTNIKSTFLYGRMEPREDVYLVPPKGITLPGLKPGQVLKLRACLYGLKQAERQWYQKLCDALRQIGFTRSEFDHAVFYRQLSLTEGSGTAAIFCHVDDMGLNKKYMPQLISTLRSRFELSKGGRIHYLLGMHITCDCEKRTISFSQSAYINRILIRYRFNEICIVTTPMNPNVTLFNEQCAIQYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY75</accession>
    <name>A0A2R6NY75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000679">
        <property type="protein sequence ID" value="PSR79901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY75"/>
    <dbReference type="STRING" id="98765.A0A2R6NY75"/>
    <dbReference type="OrthoDB" id="3228837at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="400"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR79901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="764" mass="84189" checksum="1C5DBA1BC0868831" modified="2018-06-20" version="1" fragment="single">SAAVEKEMNDLTESPGDTMILRLDVLRVKVLGQEHLPQKIARTKFSKRKFYIELKVANTKQKTKQCEGSKMLEWNEVVTFTDVDSSSTFEAAVYAKRTSILHDAVKVDGFSDSVTSILSSSETLDTLLVVTRHLDSCPAAQLEFHIKVTTSASLASDAGAAIGSTANPVQKLPGSRSPPIPTDVASAAGNTAQTVEDVLLPVLQKIEPFCEIVKSVSELHPYAKIALSIVNGVYTILKNQLQRNDKIRDLFMRMDSFYSAVGKDLKSRLGDGDPLIAVLQRIFVMTTECCSFIQSYASNLDANGFVLGALKNSFSSTDGRIKTYCDTFDFLEQTFYKALGIETQNIVQMIAEYASLDDLPHVGGASLNAEGSCLKGTRRDIISYASNWIGPSSASVAQQSILLLIGEAGTGKSAIASTIAVDFAVLGCSFGFKRGIQERCNPLNLFPTIARDLADFDDNFRRALCDSVGNKKALQTTTSLELQFQHFIKNPMASISRPILVVIDALDECGDAKDRTQRAALLKLLATPGKLPLNLRFLITSRPESDICSHFEDPNEHYIITKRMNEISIESTSEDITLYIRTRLITDSQSKLDGIDEACCQTLADTSQGLFQWAYVACKHIAYPPPGRTPWEQYTRLVQSASGTSHGNLLDHLYTEALRTLFDENDMEIMSTFNSVLGLVLFSYEPPTLAVVEAFHESLAAPNKYHDARDILRHLGCFLSGVTETNTPIRLLDKWFCEFLTDRNRSKGFFVGAAEVHLGPNPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYL4</accession>
    <name>A0A2R6NYL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000655">
        <property type="protein sequence ID" value="PSR80404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYL4"/>
    <dbReference type="OrthoDB" id="2804368at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR80404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="31921" checksum="80DDA7B9366847A4" modified="2018-06-20" version="1">MPPTTVVIPSPSPTPNQQQNDNNSPDTKGLIAPIVGGILGGFFGLIGIVVLIWYIWRKRAVILSRSPSPLPDISQMSYTGRSRTQMPDPTIEPKPYRYGGLGSTNSYGGSRPGTIRRSSMYSSHSPPPTSPHSYAGSPSPRLSSFSQGGAPTPPLLAGTALNPGPSQPSSRPSTPGYFSPHPHQGPPSAYRQSWPLFGAAGEEDRESQVDVPGSPTFGMRNERRPSRLSLTLANWNPGAEEEGRTGSRSVSMSMSGMSAHGGIEAAPRSETASLEGEPDSRSPRTTTLFVVNSDELSKAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYT7</accession>
    <name>A0A2R6NYT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYT7"/>
    <dbReference type="STRING" id="98765.A0A2R6NYT7"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="567" mass="63661" checksum="C3A18574442AF7A0" modified="2018-06-20" version="1">MKSEKDGLYPLQALVQSISLRFKYHFEGTRQTNRLDKPEWYFTHVLNASHEHRAFMENIVQRLLSSTEYRHIIAWREFTYLLLPLLHRKLRRTVPALVPHPPILAHTIYQALSFDSALKEEGFEIRGTSATASKGKDGKQEEKEQKWEGVSEVILGRREWFEAWMEGERVFAMDQYMEIISAQDAWLIIDDTGDDDESVIDRELKPTNSARRVKALVEQVTDRYSPLPQFVHRTRFMIVVQLPLLESYHARISSSLDAFETLSSTFMRAVPGALGSDPARPGDPKRLTSGVDGVQRLCKALVSAKYLAAAMEAWGEDLFFLELWSEINRKAALRSRAEAAVSLPDPKGAEDDVPEGTIFEELVVQYGKLVGRAEEMIVHTVCSEVESSLRAHLISGNSTQSTPASNVDGDHDIGLPPTLLGPIALLSSHLTYLQSSLPQATVTTLYRRIASHLATHILQRAIMYRGCARISPQEGKTIMTECELWVETCRHALSRSSGRAEAPWRPLLQAGRIVGAQGDSWRRIVDATLGRTTDQDWETVMLDAVGLAELSREDVSQAVKARADSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZQ2</accession>
    <name>A0A2R6NZQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NZQ2"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="19116" checksum="5AF6876B669FE65D" modified="2018-06-20" version="1">MDKRAEAQATAVENRNDSDAELPGYTRTASTSTSTEEHVYKLDDSKGRPWIWLHVKSRARDKKTWPLFYERDVIQGTVEVDFDKTDGAKAVSIGVTGGVTAVGQEELNFLNISKDLWDGKLSGKPKGKLSWPFSISLPGETNVADRPKARADPYRLPPTFTGIVTSFELQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZT5</accession>
    <name>A0A2R6NZT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZT5"/>
    <dbReference type="STRING" id="98765.A0A2R6NZT5"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR81583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="10828" checksum="9D11CB2CF3D5CD3D" modified="2018-06-20" version="1">MVGILKGIKSDKSVENNTKAFSVLIAFAGGVWLLCALPWFFLEKRRPGLTLPPATSLLTVGFTQVYVAFRECMRLKQTFLYLIFYFLMGDVLNTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0H4</accession>
    <name>A0A2R6P0H4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000610">
        <property type="protein sequence ID" value="PSR81681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0H4"/>
    <dbReference type="STRING" id="98765.A0A2R6P0H4"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="447" mass="49595" checksum="24465134FC31036A" modified="2018-06-20" version="1">MSLRLGFGLDGSLTTQISLEVTISFRTHKQDSPGAAGETAGTPLQMPVMNSLPASAPVFSSNFDRSKDAGRQLEMNLVEHHMCVVYTILDNGDCILSGMPSEPMLAEAAALEMNDPELPGSARDTAGFLLRQNARNGILRLDGGRGVELVAQLLLTSAYDKAIKTSQQHIFLYSKGVTVEDFIKALFSAKYAEEVLSCKPCAGSGEVPLKDAFRNAYIRFTHFALHGEGNHIDTYVALAALVRGMAVQASHDEGVINIMIPITLEKERLREEIMTGILIQIHPRSMVQTPNAEKIRFFPSDCKNVRPYITILMHLDPQSATYKRQYALAKARAQAPTNPPDLVQPPSDHSHVSLVHPRYSIAVFGHSEKVYGVVHEKASFTGLLTERTVIAEHHRRDPANLAAVRRMKPTWERNEDCFHWIDVPALQVPKVIDTEKDVEDRVFITMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0M4</accession>
    <name>A0A2R6P0M4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0M4"/>
    <dbReference type="STRING" id="98765.A0A2R6P0M4"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="111" mass="13033" checksum="70DC74E187212AF9" modified="2018-06-20" version="1">MNTVVTARLSLILREFALPSNPIFYHNELPRTPQVASSRKCYYPSCFYKTLMVLRYTRVQFFKPMWPFIAASGVTFYLVSKMQDMGVKSDEYKNDPRNPYREQIAKTSAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P102</accession>
    <name>A0A2R6P102_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000597">
        <property type="protein sequence ID" value="PSR82193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P102"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="501" mass="57315" checksum="123205F05D04D918" modified="2018-06-20" version="1">MIIPKTQEQVKVTLGKPIFTQYGIVGRRTFLYRIKTDTVVVQTPLVIKFSYQVITLQREQELVEVALKAGVKHIPKVHMWSDLWKLSEGARAIFHDDNKNAYEDKMLRALVYTRYIPLKALFKTAWHLIPYMADQILDCMHVHISCLSPKVANDGVFPIGLHDLRYKANILHRDISANNVMFEIRDGVVNFILIDYDLATMVDPDGEPLAAPSSKHRTGTLPFMAHELLDDMSRPRPPEYRRVTHRLRHDFESLFYLCLYCIFTMIKVEDEKRRMQMHTYVREWQTGSLDGIASIKHRLCADVSGDSISELVFPAPCEALRPWFLGWTDVFSEGYLALAGYKKKIRLAKWNNEKSPPGFDIDTLQGTLTRDTIKESLRLSYDRPLRPEELQVANIPDFAKDIEPYMIDDEDLEEHVQKQGSVAEKAMPARKLETKLKKAEVAKKTVTETVAATKKTTTAKIVSPIRKQSPKRVAHKPGGVLNLAAATRNMTTRSMQKGPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P165</accession>
    <name>A0A2R6P165_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P165"/>
    <dbReference type="STRING" id="98765.A0A2R6P165"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR83101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="34749" checksum="B2D5CEBDDE9A8465" modified="2018-06-20" version="1">MIDFAKSPGVTNSDALIANAVAYRQHPRNSLNINGVIPSTPYCQRPPRNPELQGLVNAQLDGVNPGIYGGPTFGLVAFGDLYTVARRKSASRGNSLLLVGPSDAGKTAILSSTNVAAVSLPPTHKTLRIIDVPGHPRIRDQFREYITDAKAIAFVVDASTISRNGSVVAEYVSLRDPYPAYSPINCRHLHQVLHVLTSLPPSQATPAFVIIAHKCDALKASASTSAEQLAINRVRTILERELDKRRTSHAGGVGIESLGGEGEEGSELSGLDCNGGGEFRFAEWEGGEVSFIGTSIRFGKTEVLDEKSTEDGLTPLREWLVDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P212</accession>
    <name>A0A2R6P212_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000548">
        <property type="protein sequence ID" value="PSR83956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P212"/>
    <dbReference type="STRING" id="98765.A0A2R6P212"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR83956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="418" mass="44922" checksum="7A0928199ADE8412" modified="2018-06-20" version="1">MDTSAVSTALPTIVNALHGKEFVWVGSSYTLAGTAFLPLSGHLANIFGRRPVLIIALLLFAFGSVLSGGAQTMAMLIGGRTEDTTVILPGKDETDRLDVRPFASPMSSYGYECSELPTLPWHSGNLLISGGSTAALLGLTWGGVQYEWSSANVLVPLILGLFVIAGFMVYEAAIPAEPTMPWRILNNRTTISGYMGTAFQGLIISAALFYLPVYFQACKSATPLHSGIDMLPYSFSIAPFAIVAGASASVLNKYRPQNVIAWCFIVVGMGLQSTLTENSEIRNWVGFQIVAGIGFGLLVRPHLFLPYSSNDAWGITIGSTILQNQLAHNLPPSFLSELQGVEIVYSAIPQIANLTEPLKDDVRRAFAQSLAVLWKVMIAISGLGLLSSLLMMEMPLQSVLDDTWGLDGQERGPETDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P213</accession>
    <name>A0A2R6P213_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000549">
        <property type="protein sequence ID" value="PSR83950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P213"/>
    <dbReference type="STRING" id="98765.A0A2R6P213"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="102" mass="11363" checksum="A79C3BEA7C73618A" modified="2018-06-20" version="1">MHLWITKESGTPSSQKVPGGEQGTYSYWDPENWEKSRKEITVLYTDLEEKSIPVFAPGQTLQMSQTQPSIQSQQQQQQQQQQQVIAAGGRAGSFQGMGMAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P279</accession>
    <name>A0A2R6P279_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P279"/>
    <dbReference type="STRING" id="98765.A0A2R6P279"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015313810" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR84188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="394" mass="41393" checksum="909C699357E4727C" modified="2018-06-20" version="1">MVLTQSLFCLMLTVGGTVSALPQPLRDSGINLSIAAKLNFSGLTSIIEADRARAHRLKNHVNLLGLAGGKRQTTNVDVTNGAVNTLLIDTGSSNTWVGAGKKYVPTSSSKDTGKAVSDTYGGGAFSGEEYTDKVDLGNGLVINSQSIGVANETRGFSGQDGILGIGPTDLTRGSIEGSDETVPTVVDNLASQGTIGSNAVGMFFAPYEEDASGVLTFGGADSSLYTGDLHYTSVTKTSPANQYWGVDQSISYGNTNILSQNAGIIDSGTSMILLASDAYEAYQKATGAVEDQRTGFLTLSKEQYGNLQPLNFNIGGNTFALSANGQIWPRSLNTAFGGDEDSVYLVIGDLGSQSGDGFDFINGYTFMERFYAVFDTTNSRIGLANTQYTNSESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2H3</accession>
    <name>A0A2R6P2H3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v5435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000533">
        <property type="protein sequence ID" value="PSR84477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2H3"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR84477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="678" mass="74007" checksum="C63C911A007AC6F0" modified="2018-06-20" version="1">MLDDNPRPQKRVRRESLSLSPPSSSPLTPPPSSPVPSTSTSQSDSPLRPLPHAVLLLSLPSLLVHPPSHRYYIQSLCLSLCSLRKCLSLPALSPEIECRAWTGLAELGMKVISSGFSQSEDHLWARGIEAEAIIAQKHPSLRVFSHHIALLQVQFSHWQHKTKFARTQIRNLIVSFRPTDPPYIVYSAHLAAITLFTTPKPRSTPSTLHTEFKPPLSPAYNQSPQDIHAALSAIQSLESLSRTQGHTRVTLLSHVLRLRVLVAANMWNEVGNAILLAESALGLSYEAITTPKPRMTNAKEKDKTEHPSTETTFISFEDALESAMVVHTLIMTVVYFTHIGSAAEASPRLSHLHALLDSGALDQFAEGIIEISLPDGPPLSIQVTHPRILFLLAFLVSSVAKRDAVGRKPKRKVFASEGLTSWEKEMDFELLLPSWANFGDVEEVEQRLARIKADLLCELAAVSIMRSEFDAAEEHLAALIAHTRTYSIFELFAARITLHNAHLAHALDHGARALECYRIAVRLAGADNFVALSARAGEIILLMGMQAEGLIPNEPPVNKKEVTSVAKACRGMGGTLEAVGHVLDALVSPEILKAKQHLKASLELASRSQDNHLRAVVLALISAHYFHTAGDHALSMLQTCSQLAAGLGAPPTKDAPGILPIVGNARLSLWVGQKFLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8Q3</accession>
    <name>A0A2R6P8Q3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8Q3"/>
    <dbReference type="STRING" id="98765.A0A2R6P8Q3"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR87345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="278" mass="28861" checksum="18046B018AD08B05" modified="2018-06-20" version="1">MTSHPLLQAFRASKPAFGAWITLPGPFVARTAALASPHISWLVLDCEHGLTSLQPGAAETVAAVSGLGANAPSVLVRIPATGACADGSASWQIKYVLDAGARGIIIPMVSTPEQARSLVSAARFPPTGTRGFGSPFTQAAWGISALDYLEHANDSVLVLVQIETREALENIEALCAVEGLDGVFIGPYDLSLSLGVPTPNPDPHPTTEEAIQRILSVAHKAGKKCAFFCTSGEQAAKRAKEGFDMINVTSDSGAMTDGLQKSFAAAAGQSPGGTRFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8Q6</accession>
    <name>A0A2R6P8Q6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8Q6"/>
    <dbReference type="STRING" id="98765.A0A2R6P8Q6"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR87340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="486" mass="52920" checksum="D276E35BACEAB500" modified="2018-06-20" version="1">MTYTDPSGTTWVYNLGDIAWVLASTALVWIMIPGVGFFYSGLLRRKNALSMIWLSMVVLATVSFQWFFWGFSLAFSETGSKYIGNLKYFGLKGVLETPSIGSTRIPSIVFCVFQLMFAAITPILALGAVAERSRLGPTIVFTFLWSTLVYDPIACWTWNSNGWSFLMGGLDFAGGTPVHISSGTAALAISIYLGKRRGYGTERLAYKPHNTTYVVLGTVFLWFGWFGFNGGSALSANMRAVQACIVTNLAASVGGLTWMLWDYRLERKWSAVGFCSGAISGLVAITPGSGFVGSPAAVLFGFMAGTLCNFATQLKFYFHYDDCLDIFASHAIGGIVGNILTGIFAQRSVAGYDGIADIPGGWIDHHYIQLGYQVADSMSGLAYSFVMTTIILWIMHYIPGLRMRCSEEAEILGIDDAEMGEFAYDYVGIDASAGHVFHDDTHSHGDIPATTGGREPHHMHTETIHAVSKDKDSTGGSDNEKIHDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCJ5</accession>
    <name>A0A2R6PCJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCJ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="16550" checksum="B511DD317675264E" modified="2018-06-20" version="1" fragment="single">TPTLFRHRLPPSSPSQQQLRQLRQWHPPLLPRHLRSLHALGQLTASLVQRKPARVAVVGNDPYRISLIVAVPWRRVLYNCLSSVQTLSWQIRRQSEHATIATVPFRSNGLRQRSASSVSSSSMSLRRRGLHLTVSSYSRSTRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJB8</accession>
    <name>A0A2R6PJB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJB8"/>
    <dbReference type="OrthoDB" id="3254002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR92220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8738" checksum="58D936A9D18BC8DE" modified="2018-06-20" version="1">MSNGQGLPVNPLDNQIQLQTYNGVISPDVYRRNMEALRAARETLAQFERQTLEGYNRFITAEQELRNRVEAGRQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNE1</accession>
    <name>A0A2R6PNE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000465">
        <property type="protein sequence ID" value="PSR93900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNE1"/>
    <dbReference type="STRING" id="98765.A0A2R6PNE1"/>
    <dbReference type="OrthoDB" id="2884925at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR93900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="453" mass="50850" checksum="F30C57BBF27C8DFA" modified="2018-06-20" version="1">MARSQGVPLTAHYRVSHSRRRGDELPSLRIALEAVHRIRTLELHIPWTMYEKVSGSMHGSAPILRCLKMRNPHSLSNVGRTPPVLAINRETFPELETLELYCYGFSWSELASCHKLKHLNIDYAVFVRPTLPTVSEVLDTLDALPHLVTLNLNNVLSIFPQASMEEPRTVTLPHLEHLILSGDATACASLLDSLSFPQCARITLLFGFIGENELPILLPPIHSRLTGASSIGASAPFHSFAFGLDFKRSLVVRGWTSTLQVESEETELAQFEPKFHLELPRWALEFDVIWNGLPLQDVRSVWVMSNLVEELSLASQLDMLRKTPHAISVRFSQWPAKNLCDLLGVDDHDGTVILPSLRTLVLDKLNFQLCIAHENGHHGCLQHLESVLESRRSRHAGLYRLILEECWHVSALEVGCLRDVGAELIWDGIERIKEDLATDSDSGMDPAVEGYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PPE0</accession>
    <name>A0A2R6PPE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v4392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PPE0"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR94660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36098" checksum="85A4FA8F1AA3AC42" modified="2018-06-20" version="1">MQRACAVLAAATANHLALSFPLPDLTVWEAATAKQLNVYKLTSGGTWAKAGIITCKSLVWLSTAYELAFIAIDSDPYSKLSQLLVAWLPEGFTDVQLDSFNPTLTTSAYIGLAILAAGALTQLSARFALKSFASFPLIPCTAASSRVLYVPPSQIPTPLTHDPSKPSPAPVPNKDKGRILFTLRPSHELVNRGPYHYARHPMYTSVSLAFLGSGLLHLSSGSFTRSLVKSSRLSLPVFSRGWAELLPQTCAGFLPVSVVDALPDSWMYARWDVGSLTWAGVFTVALGFVALGSFFGLVRMANREEKALEERFGKQWTLYRWAVGSRFIPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVJ9</accession>
    <name>A0A2R6PVJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000443">
        <property type="protein sequence ID" value="PSR97185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVJ9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8462" checksum="6B948067BA5A7917" modified="2018-06-20" version="1">MATFSEFIRFRTTGIHAMIFEILRSISCVTRGDRMKLITGNVVLAYATHQHTDGVSICIANGDRTYLIDDVVDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ00</accession>
    <name>A0A2R6PZ00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000424">
        <property type="protein sequence ID" value="PSR99172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ00"/>
    <dbReference type="OrthoDB" id="3244185at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR99172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="353" mass="39090" checksum="63A239BB958E2AC3" modified="2018-06-20" version="1" fragment="single">KLENDTLHLQDSKKAALPTNNNRDDCEQLRRLNFVNCLQDVVQYAVEKSRHPPVPPVNGNTSIPVFKQFKILLPLMSQVSQKASLDTVRAIVAKPARGRHLFIPAQFSTVLARESLLSQTDLEGIGDLVTGGNPLAGFTVGQVRVIFQLPSKYGGLASLAAHPLAYVEWFTPFQVCDKHVDDYKYTTNARPILGPQLRIKTVFPDARKQEIPNNKLNELNQSLNVWHDKQPSKEPSAPCTSELNAGSANGPFSAPLDHPDANKIIDISTMNINNSLWKEVKYGKQAKSPKNSAEPLSAQRGDAMMLDVSQRNSVEAAVSSMTAEQLDCFTRHMNAVSFKGRRREQSITDNPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ19</accession>
    <name>A0A2R6PZ19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000421">
        <property type="protein sequence ID" value="PSR99309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ19"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ19"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
        <location>
            <begin position="285"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR99309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="467" mass="52500" checksum="F17E15A8FA76E21B" modified="2018-06-20" version="1">MSEPPESNGSRQSFDSERVSSPSPTKGLNGTVNGRNEDLSNMDPVERLQHELERTKEEKDTLAAQYRNLLSKLTTMRTTLGNKLKQDAEELDRQEQLVQQLTIQNEDLATTVETMKSELIASNEEAERASRELETMRSRAFQENAQEAYLRERELREAQAELEQCRIERDEWEHKALQELVVADEAKGALEEARRDLRIEIEARDQEAAALGVEREKVDNLQSVLEDFQAETQLQLEESATNSTRTQELEKEVKEKNLLIGKLRHEAVIMNEHLMEALRRLRRSSTDTNVDRRLVTNVLLSFLTTPRADSKRFEMLTLLSSILQWNDDEREKAGLQRKNGALPSTGSLIWGRSSNAGKGKSPELEKTDETESFSRLWVEFLLTEAASGENISSMSPKSPSRPNNSLPPTPTRASHSPIYLSPGSQKGGKRLPSFSSPFASAAMSSSPNLVLNSPPQGKGKEKALDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2B4</accession>
    <name>A0A2R6Q2B4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000403">
        <property type="protein sequence ID" value="PSS01014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2B4"/>
    <dbReference type="OrthoDB" id="2658733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS01014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8711" checksum="20683C310F593C20" modified="2018-06-20" version="1" fragment="single">VCFSGLGVIFASGNLPEAHRSFESQHQCNRFCQYFQVPTDYSSWPSNNIGEPELSPSTAQEGAEEGVGFRLGPAEWSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2B7</accession>
    <name>A0A2R6Q2B7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000404">
        <property type="protein sequence ID" value="PSS01009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2B7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS01009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11309" checksum="AAC568C2F0C209E6" modified="2018-06-20" version="1">MEITPVRRIVAQGTTLPTVGLRQPICDNCPIRATDTDIVVERQAATEARREKAVEGGDRGIPCRSSTWRTNELSDWMRKVREVDGEDVREAEQAAGSFKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB72</accession>
    <name>A0A2R6QB72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v3868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB72"/>
    <dbReference type="STRING" id="98765.A0A2R6QB72"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS05379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="44606" checksum="0A6648AE895E3911" modified="2018-06-20" version="1">MTRITFCSGAHLYAVEFPQTLKANASANLIIETVQTHATYPWPQEAFQKDGQSLKYEADLFVLSPYPTVVQRTKIRSSSPQIHSYTTPEDIEAFTLESPVTKSGSTLTYGPYNNIPTSSTEDFVQTNQKRIAVHYTYDAPVLEVTKLERAAEISHWGANLNIQDNIWLRNAGPRLKGHFSRLEFQTQNYFGRSAPHTLTSISLALPPGIHDVYFYDLNGNVSTSRFRPAPSVPKGSQSNQHSILEMRPRYPMLGGWNYSFTLGWDSPLEDYAGWQKESGKYLVGIPVQTLMPSAVVDEAEIKIILPEGATDVAFHPPFPAVMNSISNHITYLDTMGRPTIKLQYQQLTDRHVGTIYVEYRVPFSAHLKKPLAVSTAFMSLFALAFAWKRVDTRIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEK7</accession>
    <name>A0A2R6QEK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v3633</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEK7"/>
    <dbReference type="STRING" id="98765.A0A2R6QEK7"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="74"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="589"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1100"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS06575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1143" mass="128540" checksum="8A7739BD5C7A8BE6" modified="2018-06-20" version="1">MDEKSHKAHRPSQSGVKAEKKQGKGKEKQHGFNEKAFAPRSGRRAERQGRRNVERDQTRLHVPLVNRTPDDEPPPVIIAIVGPPGVGKTTLMKSLVRRYTKQTLNQAQGPVTVVSGKKKRITFIECNNDLNSMIDVAKVADLVLLMIDGSYGFEMETFEFLNVLQAHGFPKVIGVLTHLDLIKKAATLKDTKKTLKKRFWTEIYQGAKLFYLSGVLNGRYPDTEILNLSRFISVMKFRPLVFRNTHPYLLADRIEDLTPREEIRESKGKCDRTVTVYGYLRGTNMRMGTKVHIPGVGDLEMKGISKLGDPCPLPDADSEKRRKLSEKRKLLIHAPMSDVGGVVYDKDAVYINVPGSFTRGNMDVPQGEGERMVMDLQDVNATLEDGVARSQIKLFGSSSKPLTVDPGPSHLHGRSSDEGEDDGDDEDDESSSGDEDEGSASGEDDDLDSDSGEDSEDEGEDEDEDDDEGEGVEDHGRPIPRNVRRSAGGLPTGHDRQGNDVEYADSDSDLGEILDEDEDDLVGKPSGKRVRFGEDDNDLNIQSDEEEISGGEEAPQWKAGLGAKALAAYQQYSRKTRRKNWMKLIYSSSLTPEQVLRDDPSSSASPADAEENEDDFFTIRSRGTVNTEEDLDMTKEAVKPEDLKEWEHEDLLDSIRNLFITGGGHTGNETGGDEGYEDTEGGGFVDLEAQGENQDGENQSEDPETARATALAAKKEALKRKFDEQYDDPESSKLDFYEEKKDEIARQLQLNRDEFADVDPEARALVEGYRPGAYVRIELVNVPCEMIENFDPTYPIVVGGLLAAEERFGYVQVRIKRHRWYGKTLKTNDPLIFSLGWRRFQSIPIYSLDDHSIRMRMLKYTPEHMHCFATFYGPVALPNTGFCAFNSLTSEATGFRISATGVVLDIDRSAKIVKKIKLTGVPYKIFKNTAFVKDMFSSALEVAKFEGANIRTVSGIRGQVKKALAKPDGAFRATFEDKVLMSDKGRWAGMRLTGQVRRDEGLKTPLNVNSTYKAIERAPRRFNTLKVPKKLQAALPYASKPKLMRPQQKQTYMQKRAVVMEPEEKKAIALLQQIRALRKDQVVRRREKQNQRKEVHRQKVAKEEAQKSEKDKEKRKEYMRAAGMKSKREADKEEGRSSKRRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEU9</accession>
    <name>A0A2R6QEU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEU9"/>
    <dbReference type="STRING" id="98765.A0A2R6QEU9"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS06847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="14646" checksum="C676DDC528C9C58F" modified="2018-06-20" version="1">MTEEEQKLFRLYGKLPTHKNVLTKMQKDRKYFDSGDYALSKAGKAPQNTVGTTIPSPENIPHAASPPVNHALSVSPTNTATSPIKESPLAEPEASTQATEDTNASEATQEATEETAQTTETAESLEEEEKNALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM61</accession>
    <name>A0A2R6QM61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM61"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS11015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="7017" checksum="B3430D41DA0732D7" modified="2018-06-20" version="1">MIHFCTLQVTTLSTPYQTHRVHPQIVHWTALDLNDEANEVESGPITQRSTISLNNLGTWSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUK7</accession>
    <name>A0A2R6QUK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000302">
        <property type="protein sequence ID" value="PSS15419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUK7"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS15419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10475" checksum="7C3F5B89EDC6EF30" modified="2018-06-20" version="1">MSLVALKENEVQERSEVAAEEWSFNPSDDLLFWQAPDGEIFTDLLETVDSKTGTSSPIAKFPRFYPYAEHASGVTRKRKAFAITTFHRTYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R797</accession>
    <name>A0A2R6R797_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000272">
        <property type="protein sequence ID" value="PSS22644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R797"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS22644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5535" checksum="FCAD2B2EC4E13806" modified="2018-06-20" version="1" fragment="single">ASLGPPNFQKGKESKNEKEVLRCSTDRHIWVNIQCCNPRSSSSNFTGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7B5</accession>
    <name>A0A2R6R7B5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytokinesis protein sepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6R7B5"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="216"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="1111"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1528"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="840"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1598"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1491"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="798"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1651"/>
            <end position="1661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS22664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1693" mass="187212" checksum="EE314A955B79DC9B" modified="2018-06-20" version="1">MDSFFGKKKSRPRQSSVSTQDLDGRSVPYHKLGPASKSPVTVNTVSQGLRGNPNTVISAPTTNPTLTANGTELNKYAMSRQRSDRERAYRDASPLRRPGSPSTSISTADSSTLYNDSESSASKVNARRYRQSESGSSLTDFGVPSPTSPTSRHRTLVADSTGGSRPPSSVPGTPRSADEKRSSRYTSSLGGFDPHHLSSISSALHRHGAPEEFVFPRPDDDEDIEALFENIRQMRDLGELPNLTIEQKWHIVYSDEQLRWKEEKQREEQAKKQSESGQPAAIIEGTPEWYIKKFLDKTITAKQAGGLQVSLRGKEVSWFKHFIELQGTSVLAQALNHISRKAMQRRKEDIDKEYEIAKCLKYILNHPFAAHDAMAHNMIVTQIASGLNTPHLPTRKLLLDILVFLVYWNEGQVHESVINALSTLSDDNHERGSCYSYWFKSLEQALIGRGKMGTFVGASEEVKRHGGHDPSLNDYTTSNFFLINGILEAIDDLDLRVHHRASMEAAGLNQIVRICRTFGVAGIETQLNLLQQTLDDDEKKLKERMDQDILRDLANPEDVYSALQSKTQDSKARDYFLSMMQHLLLIREEGPALVHYFQLIDSMVTDLVMDKKLGGAEQRLGHSVERIIAQFNEADRYQNVEDELAKAHATSLRLRLEKEALEEEISQGGEGLVGTLKSKVGQLEGKLYVSRENTTRLQQQMAAQKAGYEEQIAQLEAQIMELFRMLKEVGKGVDRIMENSGGMDRKTLIDTLERHLQRDKTISILEGRDKRRNPKANGEPGEDEEGTEDEEETPTKTGVRRRGGASMRGRTKSSKVVRASEIQNGHTSQFMDADDATAHEQIQQQLAQSVSVYPSRDGPSYSPRSMRGSPRRKDFARSNLGDFGTPISTADGLLAPPGDDLGELSDHSNFDEQDGYSDLSRSRSTRSTDATSIGSKASASGTRSTYVPGSLAEELRRQLTLKGRPPSEPSPQGSPTLPTLSEEVDSVDGAMSTAPPNPLVSGVDFDSPPPPPPPPPPPPPPGMGFGAPPPPPPPPPPPPPPGFGGPPPPPPPPPPPGSHFPIPSAFGVPGAPPPPPPPPMKSGFSTPSQPGSARGSTLLGANLSNLLSARKDMPITPGTKMKQLQWDKLPHQQVAKTVFNDDESQKENEWIKKFQLDGVWMEMEEDFKAKQLVINLMAKQKRAELKSVLDPQTKKRVEILIQTVKRLEPEEIAMKIKHFDQDVCTEVFLSELKPVLPNPEQVGKLNVYRNAEPEELAGLHPSDRLMVQLIKIERLGPRIEGMLYRRKFEESWSLLDDSARKLSEAGDALLHAKHFKELLSLILLIGNYMNGTGVKGGAFGFRVSSINKLVDTKSLHNTTLLHFLERTVSKHFPDMEDFLVELSAPAEAYRVNLLDVRKNLTELREGIKRIRQELNDHFSDVEDRYGKQMWSFVGKATSQLEDLVDDVNHADSTFDEVVKYYGEDERNMSSSEFYGIFKTFVTSYKKCKADNQSIFEERTAMEKRKQAAEEAKARRENAKAQAAVQDSEDTSILDNLLEKLRNGDSVGRKARRARPSTANRPVAVPLNLDANGLLAAGTGNDTADLARDMLARLKSDGFDALPVSPTTANPPRRTRRRAPTSTPFRGISEELQDSPLLQGMESILDGDGDSTIGSMSATSVNESVTGSETPSPEPPEGAETSERDTTPGATDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7E7</accession>
    <name>A0A2R6R7E7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7E7"/>
    <dbReference type="STRING" id="98765.A0A2R6R7E7"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="571"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS22662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="644" mass="69935" checksum="883AC0FC3934E07F" modified="2018-06-20" version="1">MAYNREWDRGKDASWNDPSWNDQSNRGQVRGREEDYYGEGKRRKYNNGGHDTSQTWDESSGYEGFSQGRTNWVQQDYVDERHHIAPAKKRQVPSEPSPHVIFLGLDPDFTEADGFGFAQFASIEHARAFVDPLFPFIQVPPPASHGASSTTAFYKALETGAPHNGRRVKIDYSQSASPGDRRRGPLNTNDGTRDIGNSQAPILLFRGLDPLSGPQAISQAMINSSGFGKEGAKGMKRIILIKDKVTMASWGFAFVEFVDIQSASAVLAATMSPQIHPSGFRISDRPVAASFAHPYSFQPLPDYSLRDDACIMSSSTLGGMEGVWVRYWDEGSTIAVLEFKVEEPVQSTPAPAAKEKEKKKKSKADAEKDKRPAEASTLPVSDKPVTLSFKGGLVAKQSLTNIAPSGPTKKPAPLALGFSMADEETAEDGDEGGEKDASEDPKVAASKKVAPMVASKKIASNITKWNQVQEVLKDGSDAPVPAVQAVVKNFKDASLRDVAREKAKAAKAKVDQPEQPKYRDRASERRIMHNQPDIPLPEGTASKVSAKKRQAEGPPPPPSPPPPPLNPGEDENNVGNKLLRMMGWTEGTGLGTDGEGRVEPIQTAIYAQGVGLGASKGKEIGKYADGYSGYVHMAQDAARERYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI57</accession>
    <name>A0A2R6RI57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI57"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="15293" checksum="8ABE62401585E76F" modified="2018-06-20" version="1">MVLQAEGEVPRGPSALIVRTDLQTEEAPLEAEVVVFAVVEEPELLMEVMIVALLPTIKAPRKAIREGTIATSLVPRKTPSITTIVSTLGYPVNTAPLQRLLVVIIQDMEIMKVRSKVTSNFKTIGSALEGQTFGVKRRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI68</accession>
    <name>A0A2R6RI68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v2874</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RI68"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1231"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1676"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1786"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1355"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1440"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1883"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1359"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1440"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1574"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1620"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1643"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1655"/>
            <end position="1665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS29726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1902" mass="213946" checksum="2D293A5595AD7EFE" modified="2018-06-20" version="1">MSPMDSLVVFRSLFQKGYTEITLIPETKDLRTIFLHSRQCTIHSVTVASYPAEFSHYDPLANIHLSKPDDCHAHPELKRKVYSALAEGDEGELSIAIPKDVVIRQSGHAAAGIMSEAATPEPQTPGFNIPSAVPAFEFSPITVNVSYSLRNPADGIQFVQPTDAYPYRVPHVYTTSSSPDAARCWVPCLDNFWERCTWEFEFVVPRHLSELEGGVSVGADDEDRDDEYPTVVVCSGELVEQVSHPHNSGKTIFMFSQSTPASVQHVSWTAGPFHMLRIPADLSTAEDVSGSSQPLMYAFCLPGREEQLLETASFMRSAMSFYSSEFGSYPFGSHTLAFVDEMPTQRFDSATLSLVTSDLLHGKGAIDQVLETRLSLSHALACQWVGINIHQKTWSDTWLVNGLGLYITGLFMRRLFGNNEYRFRLKKDMERVIEMDNGTMPPICQPQVLDPPDSNTLSFVNLKAPLVLHILDRRLGKSGTSLGLSRVLPKVFLSALSGELPNNAISTHAFLRTCRKVSGIDPRSFAEQWIYGSGCPTFTFGASFNRKKMAVEISMKQETPAFKTHEDNEVMKLLFKPVPLFEGQMTIRIHEADGTPYEHVLDIRNAFKRYEVPFNTKYKRVRRNTKRYLARQAAAQAAAEGDAEAAAAMDMVDMGFGLEIWEKEKERDNWKVADWTEEDEQQMAGQTYEWIRIDADFEWIAAINFEQKDYMWVSQLQRDRDVVAQYEAITVLARSPTPIISSTFTKTVLVSNYYFRIRCEAAQALVTCAIQRMDWLGLFHLFKLFLRYCYDPEDPDQDLFTHTYVPRPNEFSDFAEYFVRKSLIKAISRVRFETGKTPPVVRQFLVDQLRYNDNTMNAYSDGLYICTLISSLASATVSAKPPEVGEFVATEPRPTMDSQDVDLLEQAKVENDRYQKMDGLIPSAHNVVTIATIEFNLILGVANLVPLDPAQYISFTREGNYTQLRMAAFDALFLTKWYIPPIVAYILAVMANDPSRAIRRQVARNVCQSLALLVTMGLMKESVKKSKSAVLVEEDGASQEGEKDSKKNDIDFRSFRKNELGKNEMLRQSLLPIIMAPDADYEVRWSLLKFADLLIRGAPETAPSITIHLPPTPVTELPPPLPAVKPAPKLHRTMSLKAATTPAKSPLTPFMVPPKLKLPVNGPRTDIVPRTPVSTASDVKRINSRPFPVPTIPASVKVTVKPQSKNIPKARSSGMSPKDVLACQSALKKLRGNKHATIFLQAVDPIRDGLADYLDVIKNPMDLNTMSEKLKRGQYRDRFNFEQDFRLMIANAKQYNMPKSYGYEEALALESFFNTQWGRINKTLEAQAAQETAKSNQQSPHRVIANVKIPPAQPKVSLAASTPGPSVSTSARPIIKLRVGGPKANGTPISTPVSEAPKAAYKGKARSESKISIPDQTTDSYFDDGSADRDLLEEVIAIEREKDQERKQAVPDKGREREREKEKDREKEKERQEREREQHEQEVEREMKEKERKRDMKEKEKKEKEREKEKKERREKEERREKEKERDRDEKEQEKPVIPKLVIGKRKKMPAVDQTADEDELLALATPAKKERSVAASPAPVAGPSTSGRSSDKGSAKASPAPIPVPPTKNGTKNEKVPKAKGSAAATAATPKISIKGKEKEIISQAASQPKKSSSPHEDATPLNEKKCKEMLRTLTKIPDASIFLQPVDPVRDGCPTYYDEIKNPMDFGTMSSKLSQSEYRTMEEFARDVELIFSNCRTFNPPTTYPVQCADAVERAWKTTWSKVLEKKLSWNEKRSLQSIMNKLVQDPLSFVFRVPVDPVVLGIPQYFQIIPRRNARDLRTIRTKLDADKYSSVEAFEADLDLMILNARVFNGEDSEIAKVAVDLQEKYKDMLCSVRTGVSVKRKGGDKGTPQPTKKARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLY8</accession>
    <name>A0A2R6RLY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLY8"/>
    <dbReference type="OrthoDB" id="2678231at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="352" mass="39578" checksum="82E91A513E040D99" modified="2018-06-20" version="1">MLSPVLEKVTKEDKSGSGKALDLVTVDTDVEMELAKQYQISSLPTVIAFNDGKPVSQFVGALPEGDSRPVQLGKSPIRPKGYHARNSRLGISNQSRYLKARPLLPTIHEEEDEEYNSGLHYDRDFHRELDSFGREIEAETTQDYDEMEWDEETTLVALLQDDAEHEDDEELTALANKLKAPMSAQGQRLKQYMMETILPVVQRVKQVHETLEDKVDMAYGTGLLAFDEVCKRVEAMALRTEDETKTAHIDSQRTVQTILAELVEAYGHRDQLWHNLEENLGACGTHPAFTALTNPTHRMSFKAERAKAAVEGLPGEVEDAISRIEKKGKDMEKNTNSAASKQKMIKGLLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPR1</accession>
    <name>A0A2R6RPR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPR1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="8716" checksum="8A3CE6CDE6723F01" modified="2018-06-20" version="1">MLKPKTPSTFEGLGACFAKLARLRGFESKAVLTIGAWDGLLGAGGDRLKVESLAGLRERERPRGAGGAPSLSRSTEAGAAGGGCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPS2</accession>
    <name>A0A2R6RPS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000203">
        <property type="protein sequence ID" value="PSS32030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPS2"/>
    <dbReference type="STRING" id="98765.A0A2R6RPS2"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS32030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="255" mass="27884" checksum="11FB47F7458B7C38" modified="2018-06-20" version="1">MADQSNFDFLFKVVLIGDSGVGKSCVTLTLTGLCVPTDTQPLATVRTTTRHQSYIVYVALTHFLLSITVLSRFTRNEFNLESKSTIGVEFATRSLAIDTKTVKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKHATYVNVTRWLKELRDHADSNIVIMLVGNKSDLKHLRAVPTDEAKSFAAENGLSFIETSALDASNVESAFQTILTDIYRIVSSKSLEQSADPIKPSTGDSILVTPSVDTQANQGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ61</accession>
    <name>A0A2R6RQ61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v2043</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ61"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ61"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS32170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45918" checksum="73F344D16D3A3586" modified="2018-06-20" version="1" fragment="single">APEKYAQLTETYGPVFSFRQGSHITCVIGRYQAAVDIMQKHGSDLVDRPRFISGGEIMAGGMRTLLVGAGDRIRKLRRALISQMQPNAAITYRPLQMRNALTYMLDIIRDPDHHVDHARRYAASVVMTMTYGKTTPTYFTDPEVVEMTLYASRMGKLVQVGAHVVDRYPILSRVPWVTSTLKSWHCEELGLFNSLVDDVQKRMECNTIQSCFVTYLLERQKDYGLSRNELAYLAGSMFGAGMETSASAISFVTMAAATHPAEQAKVQEEIDAVVGRDRCPNFEDSLSLPRVTAFFLESFRWRPVSWGGFGHRATKDIIWNGYVIPKGATVIGNHWAIRLDPDMYPDPHEFKPDRWLDEKGNLREDMNYFNFGFGRRLEDFLLAAGQCLTYYVIVRVCVGQHVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ76</accession>
    <name>A0A2R6RQ76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000191">
        <property type="protein sequence ID" value="PSS32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ76"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ76"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="449" mass="51316" checksum="6BA7FC645AD153AE" modified="2018-06-20" version="1">MDIDASGSGGWRFAQCFGDKGEVEDITEADIISTVEFDSTGNYLATGDKGGRVVLFERNEMKKGCEYKFYTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNSAHFLLSTNDKTIKLWKVFEKSLRVVSESNLHDSQQRNLPMPTQASQLRLPRLAQQDNIIAAIPRKVYSNAHAYHIHSISVNSDQETYISADDLRINLWNLNISDQSFNIVDIKPVNMEELTEVITATEFHPTQCNVFMYSSSKSNIKLADMRDSALCDRHSKMFEEEEDPTNRSFFSEIISSISDVKFSHDGRYILARDYLSLKIWDVNMESKPVKTIPIHDHLRGKLCDLYENDCIFDKFECTWSGDDKHVLTGSYHNYFRIFDTDTLNDVVLQADKSAFKAKKVGGPLPGNKVGAKNGRPGGLRENMALDTLDFNKKILHASWHPRENTIAIAATNNLFLYSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQA6</accession>
    <name>A0A2R6RQA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQA6"/>
    <dbReference type="STRING" id="98765.A0A2R6RQA6"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="277"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS32189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="470" mass="49794" checksum="828306731A781454" modified="2018-06-20" version="1">MTSTGGLHSLATIIKRLEAATSRLEDLAALGSSAPQIQPTNTGTSPQSAEPTPVPPPTGSAAASITEVEPQSVIVYREVILEGKVKPFLELTRSFASESVIQQVLLVEKEFISLGAVIKLAASCKKPDDKTLNDLLSPLSADIGAVSHAKETSRKDRDWNNHHTVLAEGAPVVGWVAVTPKPGPYVKDVKDSTEFYGNRVIKEFKDKEPKHVEWVRSWYALLDELRKYVMEYHTTGLAWNPTGISTDQYKSGAQVATGDAPPPPPPPPPGPPPPPPPPAASAPAPSAGGAAAVFAELNRGEDVTKGLRKVDKSEMTHKNPALRAGSTVPASIGPSPASASKRPTKPSKPQALAGKKPSKFALEGNKWLITSVLVESVISSVSVTNSPSFQLQITGSAPMIQLDSTDSGHIFLSKDCLGTEITTAKCSSININLPVEGEEEGIFSEQPVPEMFKTVIKDGKLITTAVEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVG8</accession>
    <name>A0A2R6RVG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000165">
        <property type="protein sequence ID" value="PSS33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVG8"/>
    <dbReference type="STRING" id="98765.A0A2R6RVG8"/>
    <dbReference type="OrthoDB" id="3267102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18206" checksum="E10626D8F1075738" modified="2018-06-20" version="1">MQQHNPSTSSSGSHIFIDVRGNPLRVFIETSSVQARAKVVRMLRAGGAVITDNPKDSQITLVDSATEVGVALAAIWLDKPVLDAAWVYQANNWGAYIGADEDWGGYRVLGSYADDEEMPLPATSAKRGGAQNPGRSSDTQAEHSQDPSHAASSWHIQGRSDEVSSSNIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVK3</accession>
    <name>A0A2R6RVK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF1692-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVK3"/>
    <dbReference type="STRING" id="98765.A0A2R6RVK3"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="165"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS34036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="57062" checksum="372FC02A72AFA6B6" modified="2018-06-20" version="1">MAGTATTQRSKSPSLMAKLDEIVQTPLAEFDAFPKLPSTYKARSESRGFFTIFVTFMAFLLVLNDLGEYIWGWPDFEFSVDTDTANDMKINVDLVVNMPCQYLSVDLRDAVGDRLYLSDGFRRDGTVFDIGQATALKEHAASLSARQAVAQSRKSAGFFTTLFQKTQQGYRPTYKYTAAGSACRVYGTVPVKKVTANLHITTLGHGYASHQHVDHKLMNLSHVITEFSFGPYFPEITQPLDNSFELTNDPFVAYQYFLHVVPTTYIAPRSKPLHTHQYSVTHYTRTLEHNKGIPGIFFKFDMEPLSLSIHQRTTSIIQLLISHAMDVVTGADKTPGIVAAEATGVGRKKWGGSEIRSRVVRQGSGWTTEGGSPYGSYLNTPVAGAFSNPGSPYPNGLSPTPGTHSSGYGLGLSSPSLAPSSPAAPPISAVGGFPTAATVGSPYQRSGSGSPYTPPLPVPNSPPASAGLYAHFPPTPNPVDGTQTSFPRSPALGSPMFPSQHGASAPPPPRRENGVLHLSNGSLGAAGKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVL5</accession>
    <name>A0A2R6RVL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000159">
        <property type="protein sequence ID" value="PSS34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVL5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="13399" checksum="04F5CE34E9BC66E3" modified="2018-06-20" version="1">MHIVDKEQDVTKVLEELCQWASPIYGAMNKWWVRRRNVNEHLLRRIEAIYSLEGFTGERGPGVREGRLSTSPNISAKGKEVESRVSKEDSIEVDTEVFDDDKACEQFNIVVDFLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVP2</accession>
    <name>A0A2R6RVP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000157">
        <property type="protein sequence ID" value="PSS34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVP2"/>
    <dbReference type="OrthoDB" id="3249498at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="24388" checksum="2E58E6CC30396A6E" modified="2018-06-20" version="1">MDDFWGLDNEGHLVLFHQVWRPYNQVMLLLFWDLIRCPYKDKKQLHSNPLKIIGFWVDTNLGTISIPLSAINDAITAIDTFLATPSCQPILREWARLTGYLNWVLNVFPWGQPALTKLYHKMSGKTRFYAPIFINASVTVDLTWFKLTMPKAIGVRLSEVALWPLDKAADIIFHTDATLTSAISFVYSNQAFIYQIQPPPLHASKPDIFFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVU0</accession>
    <name>A0A2R6RVU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000149">
        <property type="protein sequence ID" value="PSS34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVU0"/>
    <dbReference type="OrthoDB" id="3258237at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="132" mass="14068" checksum="9D6B7D4757787236" modified="2018-06-20" version="1">MHINLRISRTNVNGASASLLFNGSAITVYGATSTDYGLFSVSLDGNAPLLLNGSAPMFRPQNMLYYAGGLSDEVHSLTFTNADPNGSWFDLDKFVVSTWQTLDDIAISSSSSSTSHLPGPSLLNPNQSPQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZD3</accession>
    <name>A0A2R6RZD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZD3"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="79"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="174" mass="19527" checksum="C00DFFF421CC910D" modified="2018-06-20" version="1">MDAQFALDLNTTPAEKICPYSDRSVSSGSRTASLDATSKHSSPVPSLSSHDSFKNSQEPRCPVIFTQEVDPNLIKISLDDRIAYLTDFLNFTSHDADVIKRIAPLVNDIIPGLVDDLYAKLFEFDITKKVFMTRNQVFMKAWARRVLTADYSNGKTWAYMDKVGIMHTGVSPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZE2</accession>
    <name>A0A2R6RZE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHLCEN_2v1656</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000134">
        <property type="protein sequence ID" value="PSS35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZE2"/>
    <dbReference type="STRING" id="98765.A0A2R6RZE2"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011026">
        <property type="entry name" value="WAS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47912">
        <property type="entry name" value="Wiscott-Aldrich syndrome protein, WASP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="20">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="492"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="58"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="281"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PSS35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="766" mass="82956" checksum="6E33F2C3DF1A21CE" modified="2018-06-20" version="1">MSSPSAVNQRPLQPVSNTRHSRITVEYHRPSRESIQEYNDLLAEANLHAAAAASFQDPFVPVRQAPPPPTSPTSSKNSVPSPPRVRNSLHKPPPGRKLSTPTPKTVDSDPFAANNNMGAGTAPPPRPSRANTATLNDIFPTQSDISHRLSDPVQYPDLGAYSDSPETQSLPPLPPIPDSSPSAIQSGSSIRSRSGTAATKSKKGMFNFMSDFLNSSKRVEISTPYDPVHLTHVGFNSSTGEFTGLPKEWQQLLQESGISKSDQEKNPQAVMEIVKFYQEGRGEGSVWDKMGTAPAPPGTQSRGHTDDGFQNPRAAPPPPKRPSGSQSSPGGPPSSSYRPAPPPPTALTPALDRSTSQRLPTSKPSKSADQLGRANTTRDRRSPGPQHSHPHQHTHSTQNGQPGTPPQAYATPKAAKTSPGSAAADLPNKTSPGGRQQSSQQPSPATTSLQKVATSGGATPRRREKKGDKDKEMDIVNRLKQICTDADPTKLYRSLVKIGAGASGGVYTAYQVGTNLSVAIKQMDLEKQPKKDLIINEILVMRASRHPNIVNYIDSFLHKNELWVVMEYMEGGSLTDVVTANLMSEGQIAAVSRETAQGLEHLHRHGVIHRDIKSDNVLLSMNGDIKLTDFGFCAQISDGNSKRTTMVGTPYWMAPEVVTRKEYGPKVDIWSLGIMAIEMIEGEPPYLNQNPLKALYLIATNGTPTIANPESLSSTFRDYLSKTLEVDADKRPNASELLQHPFFRLSEPLRTLAPLIKAARDIAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZG1</accession>
    <name>A0A2R6RZG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000137">
        <property type="protein sequence ID" value="PSS35359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZG1"/>
    <dbReference type="STRING" id="98765.A0A2R6RZG1"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS35359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11551" checksum="75D7F1227325552B" modified="2018-06-20" version="1">MDVHENPETNTVTATFELPGLKKEDVNIDVHNNVLSISGESKISADRDENGYAVRERRYGRFSRSLPLPPGVKNDEVKASLENGVLTVSFPKSSPDQAPKKITIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZY9</accession>
    <name>A0A2R6RZY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000113">
        <property type="protein sequence ID" value="PSS35595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZY9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="156" mass="17425" checksum="FFA7852E4BF360B1" modified="2018-06-20" version="1">MAERPDALSDQSSQVDTLLTSFKRFIEDYEIHIKAMIERSSEGAPECSILITSRALRTAAESLNTILQIRGAVVPTTSFGSDSSVLQHLLHSLGLRERFPTLTPSRFNLSNAISNVQREIYNPYSQRPWRPSDYPTQADPPTARVAQLHKTRTIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3C8</accession>
    <name>A0A2R6S3C8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S3C8"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1510"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="938"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1510"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1551"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1582"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1598"/>
            <end position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1650" mass="181929" checksum="357229D56A870245" modified="2018-06-20" version="1">MSTYITECFIDTNTPITGVAATSSVLAFLCFAYPCSAWLSSSTFSSSIKDLGAFFSFVTTQHPTYTCILSHAGCDTRRKESFLSQCLHFTFAHLVWIGNYGDISPHHTYSNRSEGWWSITWCSSEKAYRRYARWRKRRERPDEEGVDAAPGSRSLNKGQVPRGRLRQSGHIVVSSSKRASGQNCPTPPASPATPSTRVFAFICPALPSKSFALDRHQLCRPALAKPNIMSSQSSSSKVKRKPPPAFPYSPRYPEPDPTNPFVPLSILRARAQSSNTTLVNPSIDSHVGGHTSSTEATKTQFLHTPDAQTSDFLFSSPTRLINDPEPQRPWYGLAKGYLSDASKPLRPPRSRKRPSTGRDTTYFSDVDLSAEVRFQTQNQPAQSRQQPRNVMVSEATPRERPVSVQRRDSQYHYRRRSQSVFVSPPSRRASAVPPALGPGRNASESAQYAYGDRQSHGYMFNDMDNVDDYEYVEDKHGQETTVEPESSAHSRLTSHSSVHSDASTHSMPSRHPTPPMTPDDTLSTMSNSPLGDNTFVEPHSIEMSPPVPLKEVSSQNASKPIPIPNHDVVLRSNRDTIMAAESNRDTIVVADTPATGVRTIHSDDFSILQLPPTAPPQPSPPAPSSVEHHEPPPPPPVQITSRPPTRHVESDPETSVFERRRSRAGSVSEMRRRLRKSSNVTSTIRSKVISNPMPVVPPTATRKPSFASDSSASVSHGTEVRGSHVPPVAATALARLNQRAAVTSDSETNPRLAVPKPKKSLSHVNLGLKPLPNMSLAPTVATSANTSMASAFGNLSLPRTREDLEMPASSQNAPLTSHVDHHVLPKRAQTDVARFASETLGMGLHIPQVIIEPEYYDSDPEDLATYSILTDFTMALSPIFPIAASTPGGLDRTDSLYPHREPSPVQEDQQVLTAFAHRGYTRQTPPSPPPSPPPPRVESPLPRVVSPVPNTAPARVEQPKVAAPLYYRNPAPLPLTPPPRAKSPIAAQFHPQQLHAQLDVQQPATQVPTRARSPPPAPSRSKTVPEVRQVHREDPPARAKTVPEVRQIMHQREEDERSSQRSRDREDNGYLPVAQLRPTMSRQQTMQSQASMRRSTNVRGGSQQLFGGGAAKIQGQAQEAPAEVRGEGVQTRPARTQSPVPIRVRSPEPMLRVPAKMQVPMKDLDSPLPPPPMEVLSPAALIRDRSPPVHTMMRSPGVQTRSATMPDISSPVPTQSSPSQHLPQSPAGMPPPRRYRTAPSTPALGLETPSFGGMHSHGHEMHGRSCTPTQSAGSRPLDAYPPLDFDEDLIPSKEQLARAASLVVIAQNGVRVAFGDIFREKKVVVCFIRHFWCPLCQDYMYSISRDVNPDALRRAGVDLVVIGNGSPAMIKSYKNIFHTPFSLYTDPTLCVYNALGMTLRTNDAGPDSERGQYVKHGLIGGIAMVVRNALRVGMPVWERGGDIPQLGGEFVFGPGLTCTYAHRMRNTRSHAPIFEVLAAAGIQQYAPRAVASHDDEDRWMARRDMSLERMRTQRERRRDCSDPRWCGLTDEDGGSSGLGHVNALGGAASWESRDLGHEGAEDADTEEDRTRRADQWRSQPRAPKKNLKKTARSYRVANPDRRHPPREEKYELWHPQGGSMVDELGRKREHDSAYMLTHEALSYSFGNRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Q2</accession>
    <name>A0A2R6S4Q2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Q2"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Q2"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="279" mass="31079" checksum="68D7144662576545" modified="2018-06-20" version="1">MASSSAQKRKRDSNDLDEVTLRVAARSEAEVGPVLACFPALQPPKTTPFCLYIRNASEDESNAEKKKPRKESILVGEAETVEFVSTEESQPASAGCSYLVGIYDKRTKTTTLREAPLHILSRQVKALKNLKSIEVSSEERIKLRNTLGETFGTKKAKAAIRAQERNRVDVDAMQGVAGHLQQRIQANTESLPTQAEAKATADSNRLIPTYDENAQRPEDVYKLHDIIPEVEFNALSITPFKVAVTMHERKALLPHSRSNWINQHLSLLFSAPKPNKIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Z7</accession>
    <name>A0A2R6S4Z7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Z7"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Z7"/>
    <dbReference type="OrthoDB" id="3027018at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="73078" checksum="61806880A18D330B" modified="2018-06-20" version="1">MPGADVSTDAESRAVETQFTKASGGMEPQSPVPEQTVKSKITTMTTLPSELLLHIFALLIQWNDKDWENDGEIDWRAITLSHVCSLWRTLVLDTSTLWTCLTFHRFPAIRARIMRSKAQHVHIVYFRKFDTTGRFIPRLELALRDTSTRWRSVLWESSEAKMQDMLSVLHHGTSFPNLRTLELGVDNRGLPGTSLSPGVDSRNVECALFPLLERICLSRISVSELPPTHLPSLRSLTLHWPAHYPASRATLFRMSSLSAFLRRAPQLEVLTFSNSTPLIDVHLRLESDDHTQMTANERRTYVSPVDMPNLEHVEWSYAPAQDLWRLFSFVKATNLRRLEFHLDVIEKRWHMYDGMTVLPMDGSHPFSIAPGCPLIRFDKLEELSIFGSDTDGLCCAVKRMEFPELQKLTLGFLRSRATRIWKPPNQRQGQAGWLPSIESMFREPRFVKVTHLTLSDFKMEQSIIMSMLAYLKALESLTFDCCTGKLSLDPILCLSLNHVSPGAGAVICALSGTACGSPPGTLRRWTCPRLQSLAILDSDDVTFTCLAETVLARKQYSEGTANRNIPPDQKTRPMKPLRKLGPISYATSMNQCLSDSSPNGSFIAGWPSHQLVLPLPIRSIHIEGCNISEEQLYSLGGEYGVENLVWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S554</accession>
    <name>A0A2R6S554_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S554"/>
    <dbReference type="STRING" id="98765.A0A2R6S554"/>
    <dbReference type="OrthoDB" id="3230530at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="733" mass="79706" checksum="E949A1D88D2CF0E6" modified="2018-06-20" version="1">MVTLYLSTTKGNGGIRHFPYQGFLGLTPVRIDGIVRTRLDEDQKPIPAFSLTVYVRSYEARQTRTGSLHSRILAEYSQTVWRKPDGQDYASLGDFEHPFKITLPKRVAGYSTANYQDYRTFWRVEAVLEHAPSPSVGSRIVKYFDLALIRYDIPPSLPPPTPSSYDHPSSDPSTSLTPTLPHVTNKPRAPVLHYNLSTPTYPIGPSDLLFTSLFLRPRDPSVSIRSASLLVERRIDLLDADLPLSPSQAPTSPHPPRIAISSSLPEREANVREGESYAMAHSLAASHSTSTIDSVASTSTVTSRSPLIPYSHSHSQTPHSPLPTHQAPKPLHTSYTDPLSYTSHSSMASPTSPTSPPSDPQKTLTTTVAASSFPSFSLDPSTGVFSKTLSLPWPASRSHSRWSMGETMRGSLGSVTFWVRVKVIVTSPTTGTETIDLAPRELNIVLTNDAERRQALAKFAEAHAKSAEKRRAVTAPEESSEKEHRTVNLATADSPSPFTHSPDTPSSYPNPYYPPANVYIPPKSADTASSSKSSKSAPPPMPLLPVSASRTSTSSGFGKVLPSRKKSRRPHTSAGPQDRERDSVDVSMPMPRMGVSDATNMSPTGRSSPSSYPYPYPKPHSPTNTFSSPSSSLSLSSSSSTASSRLRSPTSIRPHSPTGSSDVVDVGPVSGGINGVGGPGMELVRAWEEELKRIEKASKRGSRDMLGFWGLGKSRERAREKAERERMAHVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6B9</accession>
    <name>A0A2R6S6B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6B9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="8158" checksum="0117B393F39425A5" modified="2018-06-20" version="1">MDHDTHFHERSVDLSTARVDDVDVVLANRLYDADIGFSDSTFCHLGTAEWDTESKIREGKRERRAKELVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6J9</accession>
    <name>A0A2R6S6J9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v257</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000022">
        <property type="protein sequence ID" value="PSS37896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6J9"/>
    <dbReference type="STRING" id="98765.A0A2R6S6J9"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="487" mass="53998" checksum="03C015C61C2AA5A7" modified="2018-06-20" version="1">MLITDIKGREEFISPDKGEDIEKWSGTSEPPTADINVYIIDVKEEARLVRRIDLRLLPASMFIYLLCFIDRSNIGNAKILNSDTGDSLAQTLRISDQQYLIALMIFFVAYIVFETPSNYMLKKFSPSRWLALLMLCWGVLTMALGTVHNFAQLAAVRFLLGAFEAGLFPGLIYCLTFWYKPEERALRVALISATPTLGGAFGGAIAFGVGQLNHVRGLEAWRWLFIIEGAPSVACAIIVIFLFPDFPETSTWLSAGERELAIERIRGVASLGHARITWRETKETLTDWRLYLHYLIFVSISVPFSSISLFAPTIVSGLGFEGLQAQLFTVPPYAIAFVVTIVVAWIADRYEMRSWAAFTTFTIAGVSYIAQGALPPDSFKARYGLLCVAVPFSYASVPPLFSWLTANLRNTGASTLAVPLNVSIGSLGQIIGIFIFKSSEAPGYPTGLFTNAAFQIEGALFVLLLRAIYVRRNRRLAGQTGVMTWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NED4</accession>
    <name>A0A2R6NED4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v13360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NED4"/>
    <dbReference type="STRING" id="98765.A0A2R6NED4"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000016">
        <property type="entry name" value="GPI-anchor transamidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR70740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41799" checksum="60E072AD54FCC2AB" modified="2018-06-20" version="1">MLSSHTNNWAVLHMANALGMYRTVKRLGIPDSNIILMLADDAACNSRNKFPGCVYANAGRHLDLYGDNIEVDYRGYEVTVENFLRVLTGRMDPSVPRSKRLLTDDRSNIFVYMTGHGGNEFLKFQDNEEISAFDIADAFEQMWQKKRYNEIFFMIDTCQANTMYSKFYSPHILATGSSEINENSYSHENDNDVGVAVIDSYTHHILEFMEGIDKTSQISMQGLFDTYNYDKIHSHPGVRSDLFHRPLKQTLVTDFFGGVAQVEVLPPTEAHPSIAALTPDSSGSHLRVGDSDPAYTMTNHSSSVGQAPYRVHSSGENEWLDVQTEIDPTMALLLTDTPELGKTTRQARTWVSTTLVVILVGFVMTRSQKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEV2</accession>
    <name>A0A2R6NEV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001304">
        <property type="protein sequence ID" value="PSR70910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEV2"/>
    <dbReference type="OrthoDB" id="2752085at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42485" checksum="478221F601BF99E7" modified="2018-06-20" version="1">MEKINLFDPPWQTDILLPVELHYPILDAVIHHGDQATLLACAMACHTWLQRCKAALFKSITVVAPTELARLLPCLNFPSSFLVRHVRRICVVQDESHQPWGHAMLADLGNRLPHVQDLSFRVRGNQGVGHIQPRFSTFSAHPTMPSLLPSLFSAFGTITKLQLTNYCFRSFTDILRLVSALPSLEDLGCEKLWWNHIAAAPPQLARTGHKLVRVRLRECRDTWPFLWLWAAPVTTSTPADSGFPGLNETDVLVAGEMGRNCTSLAATTYSDMECRRSEDKKISEPKEDSLLRRRSVYKIILEDPSSHLREIYRWEKVDEFLSRLPHLDSVVVDVVYTQSDTADNPSILNEFVDLMPLTGHKLSVKDGGGFINEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFA3</accession>
    <name>A0A2R6NFA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001300">
        <property type="protein sequence ID" value="PSR70959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFA3"/>
    <dbReference type="STRING" id="98765.A0A2R6NFA3"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="448" mass="48953" checksum="E60C8635C5CF42B6" modified="2018-06-20" version="1">MAPRFLTNLIPRKEQRRGDRPLLEVLRSLNWVQWGHFWSGWLAWTCDAVDFFSVSLSVTNLSKQFNRDTHDITTAITLTLLLRSAGAVIFGILSDRYGRKWPLVINLLMISALELGSGFVQTYSQFLGVRAIFGIAMGGIWGMAASTSLENLPVEVRGLASGVLQQGYAVGYLIAAIINLFLVPEVSASWRALFWTAAGLSAFSACVRATLPESAIFLRAKAHERASGHTTTHKTKIFLRETKEMLKKHWLLCIYAVLLMTGIKPLSTIGFNFLSHGSQDLYPTYLTKSKGFSDHDATVATIIGNCIPIQLAEMSPPAFRATFPGVAYQLGNMVSSASAQIEATGGDNLQTTLPGQTTPVPDYATVQGILIGVVSAFVLFITIIGPEKHGAHFEKHKTAFEEGGGRDDVVDDDEPQPDTAAVRDAESSRPTSIREEDEKKSSSSEKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFB0</accession>
    <name>A0A2R6NFB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFB0"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="575" mass="60954" checksum="D16FDE3DF0C4D612" modified="2018-06-20" version="1">MHPYYERTNGFRSTHRSSQPFDSVLLPIHASRRSLENQVHREGERDMFIKQTYSAYRSDDFPEDMNQDGSLPNSAGASTAEKKKKPRKWHLNAYFTKSTEGNLNTIDSIPELRGLVVPEGMFRSARNSTKKKAGGPASTSMSSDPPQAGALYSGEASGSGAAGARGKRGRDGSSVQRTYAPFPSGERQRPRPVAPAPPPTIPAHHASSPSMGQPNNLSVQTQMFPPPLPPMDVQHLRHSTSYTQAASFSFPPIPTHPHPLQHQAHQSQEMLHSPTGYGSPAGDVFSNLGYSASAPNNSTSYTLGDALSPVSSPTTNAYTNHNMPFSSPPQSNPMSFDFNAGSYSQPSMFASPGIPNNAFESPLAAHQHARRPSRGHGYVPHNNFSPHSGSSGTDSPAQSDLGSWHTPSPRPGSSIGSGSGQEEDLSAYLPMPALDFSTSNTFTVTDHSNNGNGSIPRSRSFGHQQRHLDPIVTTTGVAAAAMAMANGVMALSASLSTTDFGGLSVDSSVGGGGSLLSAGAAGEEDYGYGSESESDGAAQRVALAPLHTLQRNHGYRRSPMDDRALRLLGPPGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFC4</accession>
    <name>A0A2R6NFC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFC4"/>
    <dbReference type="STRING" id="98765.A0A2R6NFC4"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9438" checksum="1D25E815DAE55698" modified="2018-06-20" version="1">MPLRYTEDPASLESVKDISEKYIVFYSSRGEDGKLWCPDCRDVERLVEQTFTPTDGLSGLIVYVGQKQEYLCGNLPCCTPPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFI0</accession>
    <name>A0A2R6NFI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001297">
        <property type="protein sequence ID" value="PSR71018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFI0"/>
    <dbReference type="STRING" id="98765.A0A2R6NFI0"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="436" mass="48841" checksum="665FE9EDC03A98C5" modified="2018-06-20" version="1">MLSMTHAQETYSVNDLLATAQHLNNSLRTTQKWDVRDDRTTAALVKCRKGLPLLRPDHPMLTAVLLVISETLSRRFEALGEIADINDSIIFLGESLTISPSSQDGYIDDEDDLHAAALSLNVMGDALTSRFMHSKNSEDVDAAIDNYRMALALSSPDNPTHLQRRMELANVLFLRFNEHGRREDLDEFIQLERELVSSSETEPDEDGTYRSLALRLIRLGNLLALRYTNSGMITFKAKGQIEDIDGAIDRLREAIACLSGGNDLLDEGETHGSLAPILNLLGDLLISRHRKLGLIVDLEQATESYEKALALLPNNDERRPRYLRDLAGSLRLTFREKGQIEDLDGAIDRMREALACLSNGIDPADKGETCISLGFLARFLDARFRCTGERADLDEAIRCRYQAMELDPTKRYSALDNLSNHFFALYLVTRDVSGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFQ5</accession>
    <name>A0A2R6NFQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001291">
        <property type="protein sequence ID" value="PSR71203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFQ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="12980" checksum="BF8F2CB1AB1D29DE" modified="2018-06-20" version="1" fragment="single">MSSFPKSNAPPSYKAAIFSSGKQPSPATPTEEISVEAKAKSFDDSSEKTAVSTTSSAKASPSPSIHEVDTEKAERSLADDDKALAQYLVPTLPKGVKTARKKPASLWIRFRVWYNPYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG90</accession>
    <name>A0A2R6NG90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG90"/>
    <dbReference type="STRING" id="98765.A0A2R6NG90"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="662" mass="71460" checksum="63A8E5E097104E44" modified="2018-06-20" version="1">MGTGDYERRIYPEDDIEVLGDYLMYRYYPDYTKKRHEMKLSYPLPAQYRVIFDQEFAKDNSVPEQSQQQSAASEDPKKEKKGNSVTLGLWMFPSDAREPLKDVMIRLHSYVKRGEHYPDHFRYGPGRPPPPNPHLNRASQSSVQEDTDAPNVSAGGRLQQASGDTSGPSEVDKLFAKLQPQSTTPAVSNAATSRSVESWFAALAGQQELAPKNSSANPSPALTHTSAAQPAAAPASGLALLNSIFASVSQPADLGMNGAFHNAITPKRLPSQPETIQIVSPKPQSSALPQILNQDVISTLLGLAPGSRASSAAPSSNSSHRSAVNRYEGDNEFSETASDGGLSTSSTVLDEFDPLDPSPLPTFSQRITLSETDGLNHGSSSVQGDVTPRAFNKGIDPSSPMLTAQRFGHFLTAGSSVSTISSTSSTTTSSGNSASTIRSSDPTVNNVDQSANPPSHRNLVPFSPDSELWPYPRAPLNEESSDADVVELDFSDTRALSDPRIFQEKQTKQGKGEPRRKKTKKEKAADREKEREAIENGWDDPTKGEVTVGGVMSTSTSSSNSIATVDRKGKQPVNGADATAQPSGSNINDTADSARIAILSALNAHPKPPSRDLSRKQFVQEVLSLIYVCLSLCASHERLLTMTKSDNSFVDKLYQEYTSLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGM5</accession>
    <name>A0A2R6NGM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v12588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGM5"/>
    <dbReference type="STRING" id="98765.A0A2R6NGM5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR71537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="62949" checksum="7397A54F9B6F1CAB" modified="2018-06-20" version="1">MPETSVVSRTAPYLESVFECTENLYSVYLHDEETLYLTGTPSSRIDGPLGVYPGTNAHECSLRELLQTQVGEADFKWQERYGNVVHFKTALGGDMLFISDPKALQYIFQTSGYNYQKLPERRALSRLHSGHGLVWADGETHKKQRKVMLPPFSGPESKALLPVFNRYAEMVTLKWKDDLSSSPDHSMVYNVPAWLSRATMDAIGEAAFDYHFNAMEDVDSDIVKGYNGLMNIVFGSPSAGKILVLDIARFIPRAVIEWLQDYLPGKGLQKARDSEALTSGVARTLIKSKSEALAEGRRGRDILSLLVKANKSENEKTRMDENEMISSMRTILFAGHETTSNTISWALLELSRNPNAQAQLRKEIREMESAIRARGDTEFSATDMDQMSYALAVIKETLRIHPVIHHTFRRAMKDDVLPLSEPIRTKSGKLVSEIPIAKGTRVVLSIAGYNRNSELWGADVHSFHPERWLDGSIKKTQTIGVYNNLLTFAGGIRACIGWRFAVHEVQAFLVELISNFEFSLTEDIQRLRREPCGVMLPTLEGEVEKGVQMPLKVTLATRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGV2</accession>
    <name>A0A2R6NGV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGV2"/>
    <dbReference type="STRING" id="98765.A0A2R6NGV2"/>
    <dbReference type="OrthoDB" id="3267098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="481" mass="54636" checksum="2BB19E180FBC6BE0" modified="2018-06-20" version="1">MIKGECEHKRVKKMYARTNKREHEGQIAIKGHREGLLVKIKNKEEDLKLADSRGVNTPGEDSPIIFGLPRQPKKKRGRPKKAFFALGIEDSDCLPQTSFHAHHHISDSQRFAVDIPKFLAEYGEDPGVKGFLPLLKDHLLSRLTGRDFDGDEHVFSDDERDLVKIVDNRLFRHKVLRINYTTYDMRRDQDSINPRTHADIMVLSPEEDVEGQNPNMAHPYWYARVVGVFHAKVKYFGPGSSSSESQKLDFLWVRWFGRDLSALGGFGKRRLHRIGFADSEQPGAFGFLDPGLVIRSVHLIPAFHYGRTTAKLGPSILRQPQDLDEDWDLYYVNIFVDRDMFMRFLGGGIGHKATRLIVKIADTLQHFFKKKAAAVEDPSEMDDEGLDLDALVGADLIVEDDGAGSGVDEDQEDGEVEGHEEDEDEEGGDEDEDENENDDEEEDEDGDEEEDEEEDEEEEDLGPEDENREPDGEYDSGYAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI03</accession>
    <name>A0A2R6NI03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Midasin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">MIDAS-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v12199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NI03"/>
    <dbReference type="OrthoDB" id="2795140at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="123"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="483"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="920"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="1215"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="1606"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="1916"/>
            <end position="2083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR71989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2324" mass="257992" checksum="A598A9D55E160474" modified="2018-06-20" version="1">MEVERVKMETDIIGAMGEVDFQVNHSETVDGTTQLVDGWVMPIIEATRVVDARNALLIEQNYYAYADGDSIEPIHPAELSPLIVNVQGILMFRTSCTTVPTSPLVPTSTTAEALRTLAVHISLGVPTLLTSSPSSGKTLLLTHLATLLHPNTKNQLVTIHLADTTLDPRSLLGSYVTSPTRPGTFDWKEGVLIRAMREGRWVVFEDIDRGSSEVLGLIKPLLESLGVDRWIGGRGGLEVPGRGYTEASEDFKIFATRSLTPSRNGTFPASTFYGAHKFHDVVIASPTHDDLQTIVNARFPRLSGAPSQGLIRLWEAVRDLGLTSSTRTVGIRELEKLCMRVEKLLPPSHQPMDVDSDDVQDVTLWKIFSNPTICEDIYLEARDVFFGSGSTTLAARVHLDSIAAVVAEHLGLSPEKRDWLLHGRTPEFSVEKDVNGSVISVRLGANRLIAATNEADTLQVTRPFAMHKPAISLICRIASAVTLGEPILLTGETGTGKTSVITHLAALLRKPLISLNLSNQTESSDIIGGFKPVDTRIPASELQGRFLDLFGGTFSRKKNAHFEESIRKAVQEGKWKRAVILWLESVRLARERIQARLADEANQPREVEIPRKRRKTGQNGLNVSEREWIDFEDDVRKFQVQHVEGNGKFAFGFVEGPLVKALRAGHWILLDEVNLASAETLECISSLLHGPTASITLTEQGSLEPVPRHPNFRLFACMNPATDVGKKDLPPNIRSRFTEIDVPPPDADKETLLSIIAHYIGACAVGDKAAIMDTAEFYTAVRTLAEKREIADGSNHKPHFSMRTLARALTFTADLASTYSLRRALWEGCLMAFTMVLDRPSAAVVTSLAQKHILAGVRNPRSLLAKEPTLPPSRSADSFVKFGPFYLERGPLPEDFVEEYIMTPSVETKLIDLARILVTRRFPVLIEGPTSSGKTSSIEYLARRTGHRFVRINNHEHTDIQEYLGTYVSDPTTGKLVFKDGLLVRALRNGDWIVLDELNLAPTDVLEALNRLLDDNRELVIPETQEVVRPHPQFMLFATQNPPGLYAGRKVLSRAFRNRFLEVHFEDVPQSELETILCQRCRIAPSYGQRIVAVFQELQKRRQSSRIFESKHGFATLRDLFRWAGRDAINYQELAENGYMLLAERARREEDKAVVKEVMETIMKVRIDPSHMYNLGPSRPDVASYLGCPVPASSKLVWTSAMQRLFVLLARALRFNEPVLLVGETGCGKTSVCQQYADIVSQALYMVNCHQNTETADLIGGLRPVRNKAALEGEILQIASPLLESLGHQLDASHPSEAMPAITTTINVLLKSADLDATVREDLLNVHSKIQRLSIMFEWHDGPLIEAMRNGSVFLMDEISLADDSVLERLNSVLETGRAIVLAERGGDTHELSHITAAEAFKLVATMNPGGDYGKKELSPALRNRFTEIWVPSVDDRQDRELIISSLWKHDALMTQTTPLLDFTDWLGVRVNDQTVTSLRDILAWVDFSNAAYQADRSQTMSVNAIFHHAANMTFLDGLGSLAQLSSYSQSALAQLREEALVKLKELSPITEESLEDTAISDSSEYIQLGSFSIPRGPGQANPNLFSFQAPTTRNNVNRVVRASQLMKPILLEGSPGVGKTSLVSALANICGYRLCRINLSDQTDLVDLFGSDLPVEGGGPGEFAWKDAEFLRALQEGDWVLLDEMNLAPQAVLEGLNAVLDHRGTVYIPELGRSFTRHPSFRIFAAQNPLHQGGGRKGLPKSFLNRFTKVYVQELSSQDMLLVCRSLFPSIPVDILHGMITYTTRLNEEVMVKRAFAREGAPWEFNLRDVIRWASLLRASGPDASHPIRYLHTLFLQRFRTSDDRRLAKNLFQSIFSNPDDLPHNPTTEPILSPGYLQVGYAVYTREGCSLVRRTGRILQTQLHTLETMTVCINSSWLTILSGPRRSGKTSLVRLMAHLTGHTLQEISINAATDATDILGSFEEVDLKSRVAQLLGKASILLARMIASMKGSRLPNAQQFVALAKSLQMSWSEGARLGIMEKASSLLNDLEDLRMPNPAKQALTSVLNELLQVSQRAGRFEWIDGPLVRALREGLWICLDGANLCNPSVLDRLNSLCEADGMLILNERGAVDGQVETIRPHTNFRLFMCVDSHFGELSRAMRNRGVEVALLPAHHAEDKKRLLDHMRLPSGYAASTTDFYVLPLHYELVRRGLTIVEQPAAVTGLWPSDMLLDEDTLSSSIVAISEALSLCTQLSPAGFRAVMYFTAQSVSPQNIGSLVRFLRSTATVQPQRDSISTLLRELSRSRIFDIVKRCRLEASQAQSYPLELLLAQVGFVFVSFFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI81</accession>
    <name>A0A2R6NI81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Utp14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001222">
        <property type="protein sequence ID" value="PSR72069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI81"/>
    <dbReference type="STRING" id="98765.A0A2R6NI81"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="727"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="859"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1040" mass="115756" checksum="33D25C14F7A00615" modified="2018-06-20" version="1">MARPPGSNRTQKPQGSRKSANASGYAKRKSLKSQVLSNASDVYEYQPERVRRSKVKLELEKDELAGAPREDVGGSEDEGDGERRGKSLKPRLVGENDDEGGIGEDEDEDIDSDAAFDESDEERFAGFGFSYDKKQSNSKNKTNKTSSGQGVKAVRFAEVDLNEDTDEDVADEPEEDEAEASDEEEEEEGDPDEFIDVLDILDGRGDPQSEDDLGEVQKQPGARRQEKSKTPQEENNAETDIRLGEGESEDEEMDEDEVEDASEDVISVSESEDDADASALQNLETFITSLDTGKKRKVPDDNDAAETPAGQDRKQRRRLLKEQTQTGTESEFAAAAGASKLNLDDLLAPLASSSNLQSLKKSAKVLASSKTQTLAAPLPQRTQDRLDREAAYEQTKEEIDKWSATMKRIKEAEHLSFPLQAESRGRTSNLELMAKFKPTTELESAVDKLLKSAKMREEDLSQTEALKMNHLSVEEVAARRGELAKMRDLMFRNEAKAKRIAKIKSKAYRRIRKKDKAKLAAKLGELDEDDEEDEDGQMKREMDRARERATLRHKNTGKWAKAMKARGELDEDQRRDIGEMLDRGEKLRRRIQGRGSGDESEDEDDESDVEGEDAIQRIKRSAFDELEKLQEVSGVDEEIEGKKGKSIFEMKFMKDAMIRDKQRADRMADDFVREMGGQIHGDSDDGSDSHEPSQDAAVERIGGRVSYRPGNAPVLLNTFPSLASDTSSVTLKSTDFPQDGQPESPVTTSPLSTRPVLLPEEVNPWLTPREGSSSKTTQKKHEVVVSKDSAGAEKSKNKLRKRVQKREEEKEKAKEDATVDVTMSNVMTLGTASSTAGPSSQSKRKEQSAKLNKLKASAGEEEEDPEANSEVDEQEQALERKGKGRGKGVRAFEQRDLVALAFAGDNVVQDFAEAKRREIQEDAPKEVDTTLQGWGSWGGAGTKKAPHKSYLIKKIAGINPTTRTDYNKSHVIISEKRDKKAAKYLVKDLPYPYTSKAQFERNMDTPIGSEWNTRVGFQRGTLPKVVKKMGTVITPLEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI90</accession>
    <name>A0A2R6NI90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001255">
        <property type="protein sequence ID" value="PSR71682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI90"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="197" mass="22344" checksum="F1B38F95CB88D2F8" modified="2018-06-20" version="1">MDSLSEDITATLHFRKSDGDGGKETFSCVKVLHKPTPINGVQRDCLPAEFFVIGQVVEEEVQFLQEMQQGGKTVTRASFWLEERCDPTSQVQWERTLLTLRHIVRRTNVDVDTSSLFSVNAKTGAMRLRVHASELHTSRELSGYTMFDGEGDSFRLTCKSSLPSRVAVRAVFNIKYKKRARDGSYFMHAPLTYLSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIH7</accession>
    <name>A0A2R6NIH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001206">
        <property type="protein sequence ID" value="PSR72194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIH7"/>
    <dbReference type="OrthoDB" id="3014170at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="21720" checksum="C9294BFC2737940F" modified="2018-06-20" version="1">MTAVGLWIDNVVHTLQELGMDTGPNAIAEQAQGTFGDKEQGLNRPLYWASWEAEGGDGDIRKSGRLRFDVILFMFYWHLQSIQGVGLFDNDNDAPPIGAYTLSIQAVLPMGQVAWFSVDNWGNTYKYLGGRKVKSPKASKFSKTIQAFTVQDWETIFTEACALQTGFKMDGKKRKVASSTGSAYNSNDESSETQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJA1</accession>
    <name>A0A2R6NJA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJA1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5012" checksum="7C22127CE4661769" modified="2018-06-20" version="1">MSEAIQATVQLVEVPPPPPPSRSTGISGCSDAMGDATVMVMNASIIVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJL6</accession>
    <name>A0A2R6NJL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001206">
        <property type="protein sequence ID" value="PSR72192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJL6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="22287" checksum="947F585E1493E39C" modified="2018-06-20" version="1">MPPCNQRKLPLLAPLPRMQTRHGNKDAHPGQPDLPQSRQSSAVVQAEKSVKAHQEAIQRADQNQRMQAVADIEDLQDRENVEADHVANRPPPPADLPPRTKRNIAPLKNKISATEEHAQLPVKSEDSSDEYDPDTEGSDEDLVELDREEMHAPVKKCSRHKKMGHSDVMAARSFTSGIQRHASGKRKESFSTSQDDQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK66</accession>
    <name>A0A2R6NK66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK66"/>
    <dbReference type="OrthoDB" id="3357304at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="616" mass="67908" checksum="3C83C9613F1DD335" modified="2018-06-20" version="1">MHVVLQATTKESREWPYMLNYLSVDIPPLSGEPPLSINSGWTFGELAAWLLMNATTSALVQITHIQFLTLLFPSSLERKLIYILLGPLAIVAAIMQLVPLGDFSITDDKLSNISDAVQNVCNATLSLLFTGSLFIWGLLVNRKQAWRTDGGTAAFGAGALLLAVASTTINFVYIPSKDQYQWMPGLMWSVVLWQSFLAWWWWVGAGMGVGEVDELLRKEEKRRRKRKARLEKSHVRRERAQTFLRGVAGAFGYSRGAEGQRFGPATEEHPAPFSSGSASERQNSRDGSRGRRSQSRRTNRSSQTSPQSSSASSTTATASGFFGRMKNHAAARYVYGWYLLLRHAHLTAAREQAVEQGERIQQVYGQDGSTTGAAEVDPNAVGWGLGSYGLRQIEIGERERDVEAEKGILEAERASEDSSEDLEKVEHDEGAKSGVVDGPARARRRRNKHARTDTDGVAVDKKVVEVRAPDAEPPSMWYWGPLRRWRLQDSTPESGYVALSSEPDRLVGLPSPSSTASRSRITPPEETLHTTPHGGVLVLHPDGHSYTYAYGPKGLAGLLHNYFALGCAVFASIGGLLFGYDQGVIANVLVMKDFTERWPIGAWEKGLMSEYGHLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK95</accession>
    <name>A0A2R6NK95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001143">
        <property type="protein sequence ID" value="PSR72658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK95"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="100" mass="11174" checksum="6A89C141187D8620" modified="2018-06-20" version="1">MYTYSAASRNKLPPPPPQIRAACTVTALHKVNTYEIDRLVRQKCFNTKSEAETASEPKKVGRSAVAGLPELARDRYQLSGAYSIQVYTINATQTTNRRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKD7</accession>
    <name>A0A2R6NKD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Symplekin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKD7"/>
    <dbReference type="STRING" id="98765.A0A2R6NKD7"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="751"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111750" checksum="3EE69FB8EF977BBA" modified="2018-06-20" version="1">MSVPALEAEGLKLLEGVITILYTSQNTDILSSILNSWSSLTKQRPALVELVVSTLASWTPAKLAGLPAFSIKSVEKGVRILLMHIMRGPQGAQFGGQIQAALATQAQRMEAAAIEEKQRKLAVVESRKRPPSAIPTTDTPDTKRQKLVADTSSPSATFLSGFDFTSLPASLVTDLIVANLQAFSEPALIGLVQAYRHGKTVSSASTSPAAIASSSGHTPTPPPTSQAIPSAPVVPVPPIGPSRSHVSPPTGPTTSEYPTPVPEFLRKVEISRQQSQTPPVVKEEEPVDPLQMDIDEEELEYEPDKLNLELSGDQEEAAEEGLSLDQDMNISLDNQEFKLTAPKDLPEEAKEALVRSSLVRIWDGAKDLASHDMVIDAGDASGTTPADMWMLLLVRLITRVVDPTSSDSDPDDDGTEMDEDSKVSLLYAHQDRLRQTLCDYIMADFSARVRLATTWMNEEWYNDQIRSQDERNWRPNYEIWLNQLVAVYQTHLDNKDRTFSRFLLDLPAVPPDVMSLLREMCVEPDRRQVGFAALREFVAQRPSLRAEAMNMLLELTTHADKITRGAAINTVKRWIPDSEPMAGMIRDFALQLLRRLQSRPKDHQPPETQTNGNVDGIHDENMEDGQLPQEEIIQTPYLPEQLELPAESDQILQHLELLFALSTKVPEFLDEIFAAYGGMEETVQETVQQLITPLIRALGSSHGKLLTLLRTFPPGAETLALRVLTIFTENGRPSGQLVALVKSLINERDLDARFLIPIIAEMDKADILRHLPRIVSILNGKQEPKNLVRSVFSSIVTTPPQTFGSVTSNLPRDRQTELLTPAELMVLLHESEKEIGLKAAIEAIGVCFSMSDIFRSEILAVVMNQLVDEPVLPTLFLRTVIQAVTTYRSLVSFVSSTLLTRLITKKIWTNPPLWEGFIRCAKVIAPASFGALLQLPKDQLRELADKQPSLKAGLREYVMKKAGNKARVAGLLDIFSEDDSNATAAKSASESPMAEVIPLPEEQMVVEAPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKN2</accession>
    <name>A0A2R6NKN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKN2"/>
    <dbReference type="STRING" id="98765.A0A2R6NKN2"/>
    <dbReference type="OrthoDB" id="2774821at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="21098" checksum="372E72CA65F43F2C" modified="2018-06-20" version="1">MYDAPSPFTYPPTPAQEPPNISAIYQHIDEDTLNAILNHELPAAELYKLDTRRILEAQWHLIDLEDSTVSFRCVPSALEIYQTLDSLLVPLNTYFSILCIHGLSNGQPVTLPCHFFRYSSHLIKIAAQYEWQAVLLYHFAFFARRCCEMSQGSYAGWEKIDVDLMEELLVQHRKQHEVTLSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL35</accession>
    <name>A0A2R6NL35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v11086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02001116">
        <property type="protein sequence ID" value="PSR73064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL35"/>
    <dbReference type="STRING" id="98765.A0A2R6NL35"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015357291" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="258" mass="29062" checksum="4AA3A1DB47A14E2E" modified="2018-06-20" version="1">MDNPMLWKIPLILIVSASLEIAMTAPNPNGKAQSEERQRYDRDNKTRDAVPMPLGWGPPTFKGAGHVVSLLEIAAILVSLCPSALRAVHLDWIADSPFLQQGSKVAITSPFIFGFLLSVFGAYIRLTCYRYLGRQFTFSLTLQKDHKLITGGPYAIVRHPSYTGLFAFYFGSLVSQMGPGSFWFEAGLWNLAPAKGVGVVAWGVMWAIGAFYVAYRLWVGYALFERVNREDTVLMDEFKDQWVTWSKNTPYRLIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL61</accession>
    <name>A0A2R6NL61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001115">
        <property type="protein sequence ID" value="PSR73066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL61"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5021" checksum="8D14838A03B762D4" modified="2018-06-20" version="1">MLLCLPIGGGEASEAAAPSAFPAKPRLPSLPSLPSLPSLPMPIGRRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL98</accession>
    <name>A0A2R6NL98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v10969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL98"/>
    <dbReference type="STRING" id="98765.A0A2R6NL98"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00556">
        <property type="entry name" value="Thioesterase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="13">
        <location>
            <begin position="367"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="416" mass="47406" checksum="9D90AF9F1DCE0DB5" modified="2018-06-20" version="1">MSEFVLGSSTRPVTPPPRQPANLDLTPEQVKRIEINRLRAKAKQREREQNASSSSALNANSKRPLGVIPDSSTSPTAPRPEPKLKPDSRLGKYFEYDLSKMVNSKGGFLVEDGKEVDAELRAKEKERERQRAMQNMEPPIFLDPSMNPKCNECGSMDIDQTYKKVFGCLVCNGCKNSKPEKYGLLTKTECKEDYLLTDPELRDQELMPHLLKANPHKSTFANMMLFLRYQVEDFAWKKWGSPEALDVEWERRVAEKKKKKNKKFEKSLQELRKRTRETVWQRRKDQEHKHVFGEVEKDPDDYPKMAELPNNQVESRQPADALEVEQLDLNLYRSKRLWLPFSGRGVFGGQVISQALVSATNCVDPAFRLHITAPSIGSGRGVVSGRMYTQSGTLVAVMTQEGVIRADVRDPSKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLC2</accession>
    <name>A0A2R6NLC2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10948</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001097">
        <property type="protein sequence ID" value="PSR73189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLC2"/>
    <dbReference type="STRING" id="98765.A0A2R6NLC2"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015348451" description="Autophagy-related protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR73189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="493" mass="53926" checksum="7168E5EAA49C7625" modified="2018-06-20" version="1" fragment="single">EVFVIVSLTLFLPICLEQFARDNGYLLPDKTTPCTAVPAPPSIPGDSEEAGRCVVKLGWMWVDSASFSLYVNSISVALQALTVISMGNIADHPPHRKRLLLAFAFFGSLAATLFLLLPSSSPIWPASALLGICANVGFGASVVAMNAYLPTLARASEEVVSRRAELHATVSSTRHPREQTAVEARNGDESDFQNEPLLADEGGHVDEEEVENLRKEYNTALSRATSRISSQGIAFGYAAGILMLFVALVPVTLLHGTTFSLRLAIGLSGIWWALFSLPAAAWLPSSSLASKIDSENDAEAAWVEEEEENDGKREWSTRREIIGAWKRLGGMLHWREIKRLRYTFQYLAAWFLLSDGFTTITSTAILFGKTTLHMPPSSLILIGIISPCAGIVGSLLWPKLQRRFVWSNLTVIVVLVCLASLLPVYGCLGFLTFFKNGSVKFGGLTTPGEMYGLAVYFGTVYGAFQGYARAFYSELIPTGEEARWYALFSITDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLD2</accession>
    <name>A0A2R6NLD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001104">
        <property type="protein sequence ID" value="PSR73136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLD2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7022" checksum="BC250BF9A943BE19" modified="2018-06-20" version="1">MDEKQEEIHAILAVEHGWIESEVYVAPTGGGVDVVCRRFTVLFTCPPLLISDRLDRSVTLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLG7</accession>
    <name>A0A2R6NLG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001104">
        <property type="protein sequence ID" value="PSR73151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLG7"/>
    <dbReference type="STRING" id="98765.A0A2R6NLG7"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015325538" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="116" mass="13164" checksum="095A4FE5544C71EF" modified="2018-06-20" version="1">MILLLPFTLLSLTWLSFVDAGSVTYNHTCVVDHQRLQVGTYQFTTDCDSMTFCNSTSFCDWRGCRRDEFPFGYDNTSIKVPPRCDTGYFCPDEESGCQTMLDVGSACQFNRDGNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLI5</accession>
    <name>A0A2R6NLI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001098">
        <property type="protein sequence ID" value="PSR73186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLI5"/>
    <dbReference type="OrthoDB" id="2692137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="14309" checksum="49C9F508C462F9A4" modified="2018-06-20" version="1" fragment="single">TTVISFQKTRSVTKPPDVRGMNKFIISEHPRIPQPVKVWSTALANVNRAKMSANNWGCWVREPHVLVGPENTLRVQNCLCNWFWVWDAWYHMLAAMGLFGAFGEWKPTYRASLLSDYNGVLSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLQ5</accession>
    <name>A0A2R6NLQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001084">
        <property type="protein sequence ID" value="PSR73331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLQ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="16027" checksum="51C75565E3612B8E" modified="2018-06-20" version="1">MQDRFEGVVGKGYVGGTTDDDGSREGEGKRDTGRGTSDGVNGVGSETSASPCHVLTREGRWSSNVLFSHVQCPFHTTLGFQRNRGHKHWSDHTPAALQPFTMRPDIVICSRRIQQPASTRGYIKEEDAVRLRRSAFTEESWTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLU7</accession>
    <name>A0A2R6NLU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001087">
        <property type="protein sequence ID" value="PSR73289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLU7"/>
    <dbReference type="STRING" id="98765.A0A2R6NLU7"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="27384" checksum="22B1D5F5E787D6F3" modified="2018-06-20" version="1">MAKKAGFDGVELHSAYGHLPHQFLDCSSHQRTDEWGGSPENRSKFGIEVTKALIDVWGPARVGVKVNPCGGLRDMGMSYSDTIMTYTYFLTQISALKVAYITLIRHVHFLDPLIPGETELKRGTPHQVLALYGPIVKPLPHVLKAHSEKAYRGLAMPNSELGYLNPTPTRLLVNGGLTPREADQLIADGMIDGAVFGSLWLGNPDYQKRLEKGMDVDGKGINQVLDFKTFYGVPGVDPRLGYTDYPTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM68</accession>
    <name>A0A2R6NM68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM68"/>
    <dbReference type="STRING" id="98765.A0A2R6NM68"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF1">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="391"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="707" mass="80114" checksum="2B281D22F8EF2229" modified="2018-06-20" version="1">MSAVLVAPALLIHFFWYKPHPSDHRRYVKDNVEAWMFWAAANLTISWYLAVIIDAVPIFVRYLISIIWGHVSESVKSRTELYTSVKDTLKPLFYAASAWVSWVIIFAHIYKLYDMDDASKSRAQYTERLYDVVEFVFFFALVICGQQMLSHAIAFAFHRTAYRERLDKVQETLRVLERLRAYRPKRSHIKSSSMGFGSRSLNALNFANNFGHGSRPGSPAHSRATTPSNSRPPSPTQLSPIGQLTPIDHNTDGEPTKSKGKSKARHVSDWFSLTPSPQHFNSDHSTPQRHASGPMSPHRYPPNTPRRRKGSEDDTAAVLHGAATAVAKTLRTAVLHDARNLEGRIDPDLGGLGWNISSPHEAKRLARSIFSAFRSVTRTYLIPSDFFPAFKTHEEAEEAFRVFDKDNNGDLSRTEIKSTLVKVYKERRSLSRSMRDVSQALKSLNQILLAFAMVILFFISLSVFGVNVGDSLTSVYSLGIGLSFIFKNSASNAFDAIMFLFVTHPFDTGDRCFIDDENLVVKKMGLFAKTAENLTMQVHWRTPLEKLDALEKCMNDWLSTEQNRWFEPSTSVSLQNINYMRHLEITIGIGHNGNWQDWGLRLTRKTAFHAAVNHFCRQLGIEAYESPLPIAWVDQDTHDIDGYPGEEDYDNSAEYDQDAPILPQRPEEVHRPTCLGFQPPPDKPMPGIRARKSKHRKALLRTVGADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMI7</accession>
    <name>A0A2R6NMI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMI7"/>
    <dbReference type="STRING" id="98765.A0A2R6NMI7"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="38"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="463" mass="49531" checksum="CA4CFA870B6FF612" modified="2018-06-20" version="1">MVEEIMKEAECDDPKQRWLKAWFTVLGNVAHHAQGHEVVIVAASRTPVGSINGALKALTAPELGVIALKHAFEQSKVDPAVVEEIYFGNVVQAGVGQSPARQVALGAGMKTSSDATTVNKVCASGMKSIMLAAQTISTGYKSVVAAGGMESMSNAPFLLPRQNPVFGKFETKDSLENDGLWDVYNKFAMGNCGEHAASTHLITRESQDSHAIESYKRAERAWKAGAFDAEIAPVTIKGKKGDVVVKEDEEYKRVIYEKVPTLRPSFKPNGGTITPANSSSLNDGASALILMSAEKAKELGIKPLAKVISYADAGVDPIDFPSAPATAIPIALKNAGLSKDDITLYEVNEAFSVVVRIVEKVLGIDPAKINVNGCVSSGCVISFLQGVINLPDDTVVPSPLVMLSVIQGLVSLYLLSTHFNLVSTVPLVSAMEVELRRRWLSRDCNKGIILCNTLPTMIPDILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMN0</accession>
    <name>A0A2R6NMN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMN0"/>
    <dbReference type="STRING" id="98765.A0A2R6NMN0"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8615" checksum="C845ADB7D88E78E0" modified="2018-06-20" version="1">MMPSDLRTPPTPRSNAPSPKPSFDCDLLRAYMKKLLQTTLQPATWPVPRERDRVKAWMKEIGERVKERMIGSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMT0</accession>
    <name>A0A2R6NMT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMT0"/>
    <dbReference type="STRING" id="98765.A0A2R6NMT0"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="168" mass="18533" checksum="25ED32941E206938" modified="2018-06-20" version="1">MFARALQSSAIRSTLRSQHKAFHDSRICNSALHNILAGGASPSTQVKTITAEGINLADGRIIPSSCIFLDGKVFLWQTPETFWDGWGTEHFEVFDAVVPKPEILLLGTGKRLILPPPSIRQYLTSIGIQIDVMDTRNACSTYNLLAEEGRRVAAALIPLSARSWKRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN37</accession>
    <name>A0A2R6NN37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN37"/>
    <dbReference type="STRING" id="98765.A0A2R6NN37"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="255" mass="27105" checksum="2E92044D8A116313" modified="2018-06-20" version="1">MLDAALENNVQAIWLAFGNNIGQWVNYIREKNQRDGQKTLVFVQVNSLAEALVAVNEWKTDVLIAQGIESGGHGGGYAPSVFSLVSSILAALPKHGPPLLAAGGLATGAQVASFLTLGAAGAALGTRFLLTPDSLYSVPQKAALLAADSNSTVRTLAFDRARNTLGWPQGIDGRGLRNEIVQDVEDGTDISIVRKKFAERAQSGEPSYTIVWAGTGVGEMHEIKGAQQIVQEFHQEILERVQASQGLVGDSETQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNI0</accession>
    <name>A0A2R6NNI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001037">
        <property type="protein sequence ID" value="PSR73978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNI0"/>
    <dbReference type="STRING" id="98765.A0A2R6NNI0"/>
    <dbReference type="OrthoDB" id="2804581at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="475" mass="50673" checksum="2243764A0FA99089" modified="2018-06-20" version="1">MDLNTSTIVYDDSSSQINYIQGSWYELTDEGGDVLNETLTGTNDSAAFGFNFFGSQISVYGSVRISDGAARSLTPESAYSIDDTAVGSFVPANGIWDSDGVLFFDSGDIGLSNHSLLVNITFSSDLFPYYLDYLEITSPPVATSSIPPISSALPSSTLLFSMSPSSTLSYSSYVPPASSMPSSNTSSNSSGTSSMPITSNVLSSPSSSLSVLSSLSSSISVSLLPPHYTSSSPFVQSKTSCFSCNTSSESSRPSTSSASQSMKPATHTDHPRPYNIRTVAVSVVGGGIFILSVLAGLFVWCRRHTKMGPFVASEVAEVHEADISANDREMAAPLTPPPPPPPLSASYPSIIIISRDNARLFEVSSMLAAASSQTTSNDNGSRVRYRSSRPTEASRSWYTIDDGSQSLTFQEPESSNGERRSSSSLVTPEHLSRHSIVHTDSGLRFPVGTVGTRRVDHGAESYERPIEFPPVYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQM5</accession>
    <name>A0A2R6NQM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQM5"/>
    <dbReference type="STRING" id="98765.A0A2R6NQM5"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="295"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="642" mass="69529" checksum="21F6A864B9B2EE83" modified="2018-06-20" version="1">MAATFEPNRSLLNPKFEGYKLDALNQEDIITRYSLPHKLKQTTASGKSPFSFQEVQSRIRHNHLTFAPNGRAVYVDAELRVIAVDFDDVCISSSPPERLAEQEYPSVAFLDNEILFASDGNGTLYALHLQDRAPATLINAFEIPIPPEYESSESSVPFKVHAAVQTSPESCTVVLSSKHYSSVPAVSEPISTKVTKRVSQFDVWAVSVDVGMISQDQPLGLDILWHRRGEDVPLYVHYVESKKAFMLLGIASYHSIASAAPPTYEPSLDEMAPIPRSGECLDPTPAESGATPGPSKPPQYSWTQTTDTVTVAFPLPSSIPKDAIKVTFSPTTLTLLVQSAAENETPVSLPRYALKKFWDGIQPSTSFWTLDREAEHAFGLLTLYLDKQHEGTRWSHLFAPSSTATAATAGGGSSEADVEVPETLDPSELWQIREALEKYTADLQSGGEDAGGWGLGRGMPSLAEGEMDDEVDLTTGDTVALTWVGADGRVPSWCREAGSDDSPFNLLSTPLPGPSGPQPPSLVVKRGLDGVVYTLGSGGSAEDPPTWTHTSTFCVLSFVLASKRDTRFVHHVSDKAVLAFESGARGLGGNVYIYRNTAQKGDNWAKQAILKVSDGSGGVLLGVDSMDRDMYAKSPAIENIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR37</accession>
    <name>A0A2R6NR37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cleft lip and palate associated transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR37"/>
    <dbReference type="STRING" id="98765.A0A2R6NR37"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36817" checksum="DE51E4A1ACC40BD9" modified="2018-06-20" version="1">MSYSFQEAAKQQGSASGAEMDEIKRMLVETNPWFLGITALVSMLHVVYEYPHQKSISVLTLPQLRNVSVQFRRLALEKEARTCWCFRKIVTNVVVQIIILLYLIDNNEQTSWMILMGSGVGVLIEAWKITKAVDISLVAAPAGSILPYKIDIKDKHVLSVDEKKTQEFDKLAFRYVSYVAIPCLAIYTVYSLLYETHRGWYSFVISTLTSFVYMFGFAQLVPQLIINYKLKSVAHMPMKAMIYKTLSTVVDDFFAFCIKMPILHRLACFRDDVVFLIFLYQRWIYRIDPKRVNEYGQVMGSDADAVAEKTSEGATETKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRA6</accession>
    <name>A0A2R6NRA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000917">
        <property type="protein sequence ID" value="PSR75215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NRA6"/>
    <dbReference type="OrthoDB" id="3230070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1387"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1780"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1731"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1786"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1815"/>
            <end position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1892" mass="210960" checksum="ED8C6E933E2A8033" modified="2018-06-20" version="1">MAKTVREVDEEKVKDYKEDIDTLLVFAGLFSAVMTAFIIESYHSLQEDPATASLQVLREISAQTSSYSFNGTLLVSTISSAASCGSSPPFKPDITAIRINVLWFASLTFSLITASLAMLVKQWLREYLSGEYTSGLARLRVRHYRLPGLQKWKVFEIAAALPLLLQLSLGLFLIGLCFFTSAGIPSLFSPLIHSLTRLISNVIKYLPVTNVIVRSIMMDYPRASIYRLVGHIILLRQSARKVMETYISVEEDEAAKQLEFDLDILAAVDAIQADDNLLATTIYESVRQTQLDLDPEAILDFAFQILGNHSQRSADDLRSSLPLDLSSVTKRTWMAIADIVAEAISYDISIQLARDRSVSWKDWMSDALLLLVSPGPSSHLFTDHGRKFIKTCITYAPSKTSHTLISRYSTPHSAAPTGGWEVVVRILLANGILQQCSNADIFSFVKSTAMNLKATSLLDMTTRALTLELSEDHIWTLVMVAAEALHCQLDDVLAASTPWGTWMDEALLFICKATGNKYWLQTDLIRGIHGKLLVGLSAPHFLRFLANPSNAEILENDTMRLLPTATDEDYPWFKSPERTPDTWSALLEDFIQVSTHASSDENMLLLCRPAILLIHQFEREVATQNGQRLFPQMTSIIKAQLNLPGYVLGREQEVRRQKLAMQCLASIDDYEQWSHEFFMWKHFTKLVDSTKLSAYDEWKRFFDPRKSPFNDDLISVLNDIAPRMDTFRVRLLKEKRTALEASRRSLRARQQSQFNGRRERSSGSISLGGALVIGRWMGRYKRRRAKMPRIDKESDDSDVARDGGALSSGSSFQTNTTERSERTLDRDDSLAISPDREHSAIPLDRGNMHFLDPYHAQASGPSPSTSSHLNVGEPNQEEHEGSPGSDPGLTIGSGYENEGAYLGYHRNSYGSEDQEDPEGPVIPIFTGSSWGGDAQHYVLDHVSNYDVGVQHQESEAQTEPIATNDTSIGDGVSEDFEADNGAPLTTPTRRSTGLSDPIDVSTGVGQGSALSPILSSLYLASSVQKFYSEHLRELGNNTSLFYVDDGNIIVSSDSPATNAALIGGLYQALERELTRKGLSAEQTKFELMHFLAPRRGKQDPVKAWPMLWHPPDGAQGPPNQVMSTLGPSVYIKAQNGTIISVTPTDVLRYLGFFLDPKLNFNAHIERCAAKASSTVTALRMLGNSIRGLGPLYKRRLYIANVVPVMTYGMQLWWHPNLRNVKRHMAELAKVQAKAARWITGGFRTTPIGALNALAGLPPIKERCRHLMNKAALRVRKLPDSHPIRAVLPDYWIVNQVSEALPFQSVSFRKPDNTPIRHIDRVGRSSNEDFARLHPENRPGDRLLEEFPDRINFCLSHPPKSKKEEFEHWYENTFVPKLRALTWGFEGKQGIYIVFTDGSAKKTVRPDKPTRYRSSSSYLILKQSLERNRHVKHATLASGKATSYDAEVMALAAGIKNAIRAGGADLRKLHVFADNQTALRNIVEPGCHSGQKFILSVIKDLRRFLGESPEHSITLHWCPAHVGVPQNEFVDQLAKSGLKRRSPDYRSLAFATQMSTANMYQAWRAAPGNMGKSWLCPAGGFPLSHTAKSPLIANFGKLAASITARITRVVTGHLPIGEFRQKFNFDGPKKCLCGQPLETRDHMMFDCPIWMMREPNFTKEWLTNTATPKQFIRAVANFLSAHPLAGSFEMADAYKASEEENQTLGTDAGPLRRALLQQLKISVGRWRLWQGNEPIPEPNNETPEEKAAREARNYERADALIVLEFPEGANQHDALVMPQTQSQLRIASPEASPAAAQAANLTQAPPASPTRRTPDPEPPPGQIDPEPPPPGQSDFSLLEGTLTTSNVFAVDEWPQTEHDMRIQVARDLADIEADQVAAIRNYMEYSPQLRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRL7</accession>
    <name>A0A2R6NRL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v9156</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRL7"/>
    <dbReference type="STRING" id="98765.A0A2R6NRL7"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR75398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="581" mass="65563" checksum="D049217FD9208878" modified="2018-06-20" version="1">MRSPALVPMEFDREFRPHSQIRALLASRRTRYILGAVALLSFVTAFFAFSGPEPFLRSGSTYDVETDVPPPPTPHDWPRPGSPPPKLSSETSGDPVWRERADRVKDAFVTAYTAYEKAAFPHDELLPVSNGHSDHFNGWGATLVDSLDTMILMGLDDLSNKTVGYIAQFTFDDDQYVQFFETVIRYLGGFLSAYALSGNPIFLTRADDLGRRLLPAFNTQSKLPAFAVNVQKGVPRNGWAGNVALLSEASSCQMEYRYLAHLTGRPEYIKAVDYVTDLMHQHEEEGGLYALMFNLNNGEPANMMYSVGAMADSAYEYLLKQWLMTGRTEPKFLHMYMRSANAIIEKLLYLSPSRQLLYVTDVHRGSLLPVGDFQHLSCFIGGLFALGAATIPNVDPRHAWAAEGLAHTCWVTYADMPTGLGPEKVMFANHGTKWVDALDAWEKSGRPGAVPPGVNQTNPVKPGEDKEYRITDSRYLLRPETIESFYILWRTTGESKWRDRGWAIFDAIEKHMKTKYAYGSIANVNQIPPALSDDMPTLKYAYLLFTDEDIVPLDKWTFNTEAHPFPTFEWSDWEKNYFEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRU6</accession>
    <name>A0A2R6NRU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase ausD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRU6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRU6"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33182" checksum="34DFDFC1F9AF8535" modified="2018-06-20" version="1">MSTLQTQQEEGARPSLDEQLYALDEAEFEFFSSQTGIKDGEELKKHIVKVQTEAYAVHPYRCIRGFAFTKLKISRFPAYPKLLQLGRERPGALFLDLACCVGNDVRKAVADGFPISQALASDLHSAFWDLGNELFKTTPQAFPVPFIAGDAFDPSFLAPLTILDVLPSGSHPALSSLTSLTPLHGRLSIIHTSAFFHLFPEEKQLELAKLIAPLLSAEPGSFIFGGHGGLPEKGLRLRKNSHGIHMFCHSPETWKELWERQVFQEGQVKVDAELRQSVRKDLPPGTQSYVLVWSVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NST3</accession>
    <name>A0A2R6NST3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v8744</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000868">
        <property type="protein sequence ID" value="PSR76003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NST3"/>
    <dbReference type="STRING" id="98765.A0A2R6NST3"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003652">
        <property type="entry name" value="PRK05286.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="14">
        <location>
            <begin position="118"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR76003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="503" mass="53163" checksum="F1EA3642FBF9F240" modified="2018-06-20" version="1">MAAPRFALSGTLGRLNLSQGVRRSQRFASTSAGSPSPSSSPIRTGLYATAAVVSTGLLLAYYFDSRSAIHRYVVPPLIRRFLDPEGGHKLAIGVLRTGLAPRDTQKDDEILKCTLWDNITVSSPIGLAAGFDKHGDGIDGLFNFGFSWVEIGSVTPKPQPGNPTPRVFGLIDGGVINRYGFPSEGHAWMLNRLRERIPSFFQPADDSRASLRPGSVLAINLGKNKSSPPDSINDFVTGVRTFAPYADVLVVNVSSPNTPGLRGMQSRTLLEELLGGVSKARDEAVTAGVAGRKPKLVLKIAPDLSEDEIADIAAAIRTSGVDGVIVSNTTVRRPPGLKDPNQVEVGGLSGIPLKPYSLATLRSLRPLLPASIPIFGCGGISSGADALEYAKAGATAVQLYTSFGFDGAGTPRRIKDELVDELKREGTTWAEVTRKAIAEKSLKEEPPVEPVKAGKGAVEMLVAEAKELGRLLDTFGERFRSSQTGSGEVNADAAVAAAVPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTE1</accession>
    <name>A0A2R6NTE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000849">
        <property type="protein sequence ID" value="PSR76340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTE1"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015327426" evidence="1">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="18684" checksum="52E318389A456BD0" modified="2018-06-20" version="1">MFSLATAHVMIGLRRALAAFLESSDLPGGALGYYAEISNWLSIFKQALYATNNYTHLVPLAGDIFLPGWKSHAQIPSGCGNHGIVPTLIIVRVGLGISTQETTFGVSSKMAFSSRPSELPMKPRRVNLSQDPVRTQAATLETVMDGLSHTDSLYNEHNSLSKTRIHDSDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTK0</accession>
    <name>A0A2R6NTK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000846">
        <property type="protein sequence ID" value="PSR76412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTK0"/>
    <dbReference type="STRING" id="98765.A0A2R6NTK0"/>
    <dbReference type="OrthoDB" id="2728219at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="277" mass="30615" checksum="390055226B31C858" modified="2018-06-20" version="1">MQAFLSLALGDDELDDSEDGESKEEEPSEGNAVEDGGDSEEDGAVEGPRVLGDVSLAKRPERAYPRTLPELGTHFGVPHLPSLVAFFLYDQTHSEPLPDGSPTPPCPPLQHIKVYHSAAATFYAPSDISGIGGMRRERIRATPSWFNGPPRYDCVFAENDSTVEGFRGLHAARVKTFFSFECGGVEYPCALIQWYSPVADEPDDLTGLWVVEPDFDNDNQPFYGVIHLDSILRLAHLIPDFGDAVLPPDFLQSQSLDAFKTYYVNKYADHHAHEIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU10</accession>
    <name>A0A2R6NU10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v8241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU10"/>
    <dbReference type="STRING" id="98765.A0A2R6NU10"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR76644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5517" checksum="717E9BB91828175C" modified="2018-06-20" version="1">MSEKLREFAEIPQEFIKDGQQICKAVAVGFAVMGFIGYFVKLIHIPMGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV60</accession>
    <name>A0A2R6NV60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000795">
        <property type="protein sequence ID" value="PSR77393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV60"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7601" checksum="F3F3CFC932654CC3" modified="2018-06-20" version="1">MNALPGYAPDSPPEIIRSFIIQASAFSLQRMAWATSSVPILSYHMPDPPQILRLTIRSELAILQSPMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWB3</accession>
    <name>A0A2R6NWB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWB3"/>
    <dbReference type="STRING" id="98765.A0A2R6NWB3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015308084" description="PA domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="2">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="194" mass="21320" checksum="7BDCC39DF66FFBBB" modified="2018-06-20" version="1">MHITSFVAGTFVCTCLFSQVHGHPIDWFRKVASSSREDGSWLWGWAWAADGSVSVVDRSPALVYPARPASFGIELSDSLLGYVIPLSSFTAPCSAGNNTSHYPFIPNPVQGCPDLCVDGPYKPDQFESWIALVQRGGCPFVEKARQAQKLGAKAIVVGGDRENPDALLNMYSESAFWVLIDITQLIRSFCRRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWI7</accession>
    <name>A0A2R6NWI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWI7"/>
    <dbReference type="OrthoDB" id="2953893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="14819" checksum="8E0DAED17CCD22C9" modified="2018-06-20" version="1">MATQNTASGIPSDIAKLTGPVLLGDFFNWGLFGVLCVQTYIYYIAFPRDRLLPKFIVWFLFMQELLQTILVTRDAFTSFGFQFGNVIDLDNVALMWFSVPILTATTILRMEDCDVFTENVDLMHCRDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWK5</accession>
    <name>A0A2R6NWK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v7449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWK5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWK5"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR78327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="449" mass="48968" checksum="FC9317BFFCDDCCAB" modified="2018-06-20" version="1">MAIFSSILPNLVGHTLHSGPVKLRLLHKAGCGAYGVVYLAWDLSTPQHNPTFYAVKCLLKYEPGSDLAHIQQREIAFHKSVSHHPNVATLHTVIEEEYYVYLVMDYYEGGDLFSAICDRRSFVDNNHNVKRSFLQLLDAVQACHDAGIYHRDLKPENVLCSQSDSRFFLSDFGLATRSVVSSSFGCGSSFYLSPECIGSSSDPVPYSTRHSDVWSLGVILTNMLTGRNPWRVASAALDEGYAQYVRDGPQYLACVLPISLEAAGILGKILDPNSLTRTTIPELKVAIMNATDFFPLDDVPEYIRLADQSFETSLENADGDVGTCSVIDVTFEMQVPPSLIPMYSGPSSDVRTLTLEITTSSFVNQISSSTTSDSDSESGGPVTPVTRSIELTAVVPHLELAADMGSAGVEQVVLVAEPAKAHTARARRPSSTTVQRFIGAIHRMAVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWL9</accession>
    <name>A0A2R6NWL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWL9"/>
    <dbReference type="STRING" id="98765.A0A2R6NWL9"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="203"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="783" mass="84695" checksum="1BA8320DA8B9FA4D" modified="2018-06-20" version="1">MHTEDGRSITAVAKEKEEARREHEQAIQQGRMTGLVEHVTDDVFTISLGSLPSLQMITIRLTYVLDLMDDDLPDQVRFQLPLCVGMRYGTLPPGMQGAKTIPPERISISAEVYMKGAIESITSPSHSTLNVLSDGSVHVGPSVHTRTAEYRSSEFLSQDFILSVKAEGLDTPRCFAQRGPDGSVAMQLTVVPKFNLPTISSQEYIFIVDRSGSMRGDRIETAKRTLVMLLRCLPSQGTSFNIFSFGHRCDSLWQKSMQYDASTLEIATQHVDEMQANYGGTNIQSALNHVFSSRLSSSPTAVFVLTDGEAYDIDGTINAVTQAVANAKKGADLRVFTLGIGETTSTAMCEGIARAGTGVCLMAATSETIIGKCSKLVKASRAEILKDVSIDWGISERLVDSKDKDDAQNTPFRQGPSKLSSLYAGNRFAVFAIFKHERFEMPREVVICAHRTSGEELRFAVAVEERSSTTDRSAPQRPLIHTLAARRIITDLEDGSQYPIPLDTKAAIVHLGEQYQLASQYTSFVAVEERSQQPLLSPGDKHVIVPPQVHREPRVGSSSGGLRAGYGSSVGRGRVGWRARSSFGSERGRGGFGSGRGRGGFGSGRGRGGFGSERGRGRFDAVHSRPRPAIFPGMGSATQHAAHATPPGKKRKTADYLAQSQAAGSSNGTATTTTDGVVLQGTPRSAEDQLVQLVRLQSFDGSFPANIMLAQIVGKKALDEGRRKLGVDAVVWATVLAVAYLQKYMVKQPELLEGLLEKATEFVKQRPGADMAVLLAKAQALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXC9</accession>
    <name>A0A2R6NXC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000708">
        <property type="protein sequence ID" value="PSR79135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXC9"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="980" mass="111199" checksum="9F83393BC282D533" modified="2018-06-20" version="1">MPAIPSRHRRYGKEDRAYNPLRLPCLSCHRIFRNLSGLTKHTNTYHTRPHGHTLLIHKTAIVEEADHTNSDLDDGPQGEAPGNDPQMLQEGQLYHLVHPVLNGRPCSSNGEFLQDPSCLPPSRTKSTANDWTPFASRLQFETADFLFQRARMSQGNIDRLLELWAASLLPYEALPPLASVQHMLETVDLIPFGDAPWTSFKARYTGDLPPDPPPWMSAEYEISHRDPLVCVRNMLANPDFADEFDVTPYREYDHLLKRQYTNLLSGDWAWDQADIIAEDPETHGAMFCPLILGSDKTTVSVATGQNEYHPVYMSLGNVWNNVRRAHRNAILIVAFLSIPKTEKRYANNAQFRHFRRELFHASLSTILSPLRASMLKPEITRCPDGHFRRVIYGLGPYIADYMEQIVVTAIVQNWCVTCPTRRQNLQDFYEGFDVRTREHAKDLADAFSRKELWDNYGIISAITPFSDDFPRADIHELMAGDLLHQIIKGCFKDHLVDWVFAYILLEHGETEGHEIWGQIDRRLAAAPTFPGLRPFHQGRDFKQWTGDDSKGLMKIFLPAVVDFIPPDMTRAIKYFMEFCYLVRRSIQTEDTVARITHCLERYHHYRHIFVTTGVRPDGFSSLPLQHSADHYPRHIRQFGAPNGLCSSITESKHIKAVKEPWRRSNKYNPLAQMLTTNQRTDKLAAARADFNDRHMLQGSCLSEALQAFLSLALDEAELDESEDQQGSTHKSEGNAVEAGDDVDEDGAMEGPRVLGDVSLARQPERTYPRTLPDLGLFFGVPDLLSLVSTFLYDQTHPEPLPDGSPTPPCPPVLSIKVYHSAAATFYAPSDISGIGGMRRERIRATPSWFKGPARYDCVFAENNSTVEGFRGLHAARVRTFLSFKSGGVEYPCALIQWFSPVADEPDELTGLWVVEPDFDGDNRPFYGVIHLDSILRLAHLIPVFGNAILPPDFHQSQSLDAFKTYYVNKYADHHAHEIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY57</accession>
    <name>A0A2R6NY57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000681">
        <property type="protein sequence ID" value="PSR79847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY57"/>
    <dbReference type="STRING" id="98765.A0A2R6NY57"/>
    <dbReference type="OrthoDB" id="3268478at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="352" mass="38524" checksum="7420B579CB69DBEC" modified="2018-06-20" version="1">MHYYNSASLEVQQKVSHLAVLAKSLLPSSDDSALVSSRLSSILYYSRPSIPFSRGGGGDDDDDEGEEEGEDHDDGRIAKGQPTAGLAKIRMAAILANTHSHTWARNVVPAYMYAVGDIGYVPRAGGEDVTSFVVLSNVFTAPDAERFDRRGNACLGVSESAHGWQRYLQGAFQEQKLQPFALPQNAVSGWPIVLSAGTRQNVQLVHERSFTSVSAAWKVLLEHAKPIATSHGLEPQDLMLITRAGIDQRFVVHDLRSPPPPLHNPHFHSPHHHRPGFPQHQHQQMMHGYGAGGHRPPGFSGFGAPAPPALFYLFTSPEQGFEPYISETPMYVPVPEGTKRPDVRQCLCGMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZE8</accession>
    <name>A0A2R6NZE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZE8"/>
    <dbReference type="STRING" id="98765.A0A2R6NZE8"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR80707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="171" mass="19911" checksum="49C5D9D77D07026D" modified="2018-06-20" version="1">MTEKAVGKPWTQEEDNRLIQAVSIHGENDNWKNVSFCVPGRTNKACRKRWLHSLSPNVKKSAWTKEEDELLLKLYASHGAKWSLIARSILGRTDDACSKRYREALDPNFNRGEWTPEEDRLLLEAFGRLGGKWKQVGQELTRPSLACRNRFVREPLEYPFIAHRYRQVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZH1</accession>
    <name>A0A2R6NZH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000624">
        <property type="protein sequence ID" value="PSR81234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZH1"/>
    <dbReference type="STRING" id="98765.A0A2R6NZH1"/>
    <dbReference type="OrthoDB" id="3268967at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="361" mass="41382" checksum="4F8947C7B96933D8" modified="2018-06-20" version="1">MSVIVSWCHALGHYERMYFKLAHDTLGHWGNVKSYAAICSSYYWPHMQKELKTMYVPACEACQQNKSSTSRLAGPLHPLFMPNGHCDSVAMDFVGPLPEDDGFNCILTITDRLGSDLHTVPCRTDILAKDLATLFFQTNGSSERSNRTIIQAIRFHVKRNQQGWAHALPLVWFNHMNTINASTGFTPFQLHSGRHPRVIPPLVFNHTERSPDSIGAAKLIKQLDTNVMEVQDNLLLTKSNQAYHVDKARRPETVYANGDKVMLSMFHRRRDFMQRGDNQVAKFMVRWDGPYLVNYPIFDPDTGEDQHFVEHILDSWRRGCGKQNLVRWKGFGVEHDEWLLGACVNNLEALNVYLRENNLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZH7</accession>
    <name>A0A2R6NZH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZH7"/>
    <dbReference type="STRING" id="98765.A0A2R6NZH7"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="3">
        <location>
            <begin position="67"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="2">
        <location>
            <begin position="262"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR81312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="73617" checksum="1C656EC93D179C6C" modified="2018-06-20" version="1" fragment="single">MDTPPDTLPDHDWLDLISDANSYLSLHLLFTYLFTGLTLYFIYRNYQKFIRARQLFSLELVHSIAPRTVLVTSLPPHLRGDRALAEYFENMGLSVESVSVCREVDSLKKLLDRRTESLMKLEAAWVKYLGNPSRAAPVDSSTEPLVHLDGDAAEEQRERLVVPNRKRPVLRPTWFSAKVDALEYLEAKFKEADEAVTRRRRTGKFKATHVAFVTFEKMSSAQIAVQTAHAPNPGQCITYQAPEPRDIIWTNMGLPPKSAAIREYMILAAMCLLLFFWFIPVTALAGLLSYKEIKKTLPALARLIDANAPIRAIVQNSLPSVAMISLNACLPFLLEGLTYLQGYRARSWIEYSLLKKYFLFLLINVVFIFLFASTYWQLVRDLANSPMKIPEKLAAALQQGRARHFFLSYVMLQGIGLMPLQLLNLGVIIPRLFYRLFITRTPRDYAELNAPPMINYGVVYPQAILIFVITLLYSVIQPLILIFGAIYFGSAYVVYKYKLLFVFYKPYESQGQAWPITFTRLIWGLIIYLVFMSGIFILRKSYILSSLLVPLLIGTLLWAWYTNKMFRPLSKHVGLSSIFEVQRGEDTADVVRLRAGHPVSWSQSYLNHRRYAQNDETLYVAPEDERTDYSQPPMANWYTGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZU6</accession>
    <name>A0A2R6NZU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZU6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="149" mass="16175" checksum="E4978AB0D96BC0DA" modified="2018-06-20" version="1">MHTPAHLPLRLQEPALPVPTQRPPSPETQIIPPGQNPAPLFNNLSDDELLALWTRVQPLLPHDPPRPHFTPPPPPPPPPPSSLPSNPMIADPSVIANARVAAASAGDSRVTPLPPIKPGFLATSFREFFHHLSQVCCTSTSHNLRITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0G6</accession>
    <name>A0A2R6P0G6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000597">
        <property type="protein sequence ID" value="PSR82195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0G6"/>
    <dbReference type="OrthoDB" id="2793915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="282" mass="32469" checksum="D4BCD179DCEC3DCD" modified="2018-06-20" version="1">MDSLGDSHFDLHPDEFFRPQGALNDPSIPAPSDEDIFTTRHGHADFDRFLLTESPEAFAQFSRWKDRMRAREPVSMTDTVVIAQTDGFAAWRMPFEPRYPLEALPESTEAHLHTIKRATFPLFAQMLEQSNSFHLSLEKELTPINGLGYARTFVCTLLQVDGQEVAGNAPDKLCVKIFDDSYGEVSDIHSRPLWMQLFHTATELIQREENTYTRLRHAWGSALPWYYGAHSFTDIYGRNFYGILMEFVPHVEQDIKQFKVHDMLFEFYNTPTSAKQTGAPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1M3</accession>
    <name>A0A2R6P1M3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1M3"/>
    <dbReference type="STRING" id="98765.A0A2R6P1M3"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6593" checksum="64AD87E81157A47C" modified="2018-06-20" version="1">MQQKDEEILARLGYKQEFKRAFTPIEVFGIGFSIIGLLPSIAYVALQLNYSMHSNSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1W5</accession>
    <name>A0A2R6P1W5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v5570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1W5"/>
    <dbReference type="STRING" id="98765.A0A2R6P1W5"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR83861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="386" mass="42746" checksum="4183BC78B51CAB78" modified="2018-06-20" version="1">MGNDISKEGFDGPPEVLKGRDIASVATYIKSKDCKNVFVMMHSLQANLARLNLPYPEAVFEINFFRENPVPFYTLARELMPGKYRPTPTHSFVKLLHNRSLLQMCYTQNIDTLERMAGVPEKAVVEAHGSFANQHCIECGSGYDQHTLKDEILRGEVARCDECGGLVKPDIVFFGESLPPKFHNTIGLLRSADLLIVMGTSLKVHPFASLTQLVPESCPRVLVNMDPAGDIGSRPDDVVLLGKTDEIVRDLCKELGDDWLEELEALWKETEKYTSQETEAEKAAGEARLQLQPKLTEEEKLKQEVEKLTEDIGESLRIGKVPTSDDDSGIPAPEKEEESPEAQAAREVEEAVATQTVKPEDADESDKAEDNFASPTAEGDATESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1X0</accession>
    <name>A0A2R6P1X0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000551">
        <property type="protein sequence ID" value="PSR83797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1X0"/>
    <dbReference type="STRING" id="98765.A0A2R6P1X0"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="543" mass="60478" checksum="1A9F82FB03EA0F48" modified="2018-06-20" version="1">MSLKTHLDVLQDSASQFSTRAAFKLPVQSPGSHEVQEWSSVAYAQFQSDVERYAKYWGRTLASDGLPRRSVVGLWLSGLTYIDVLHIYGVARASYIPQLFSLRLPNPDVIYELLHKGGASCLIYDPSFRNIVSNCPVASHPAIEVSEDDVEGASLAPLSDAALQPDDIVMIFHTSGSTSGSPKLVPCSLRWVDSIIAKAEKVSRPKNAGRQDVSVWMGSMCHIGQTFMLIGALQHGSCTIQPTNIAFDSDELVDMINRCHLNRLNQFATFLTTHLRRSHQDPKLLGLLAGLDEVLYSGLPLPREEEEWAARNGITLRNLFGNTECGAMLLSIGGDGEDSRLLRRIEGTSYDFNSISSTSQAPTSTETTHVNANANLLELVIRSDSGDCPHPSLRQVDGHYHTGDLFLEVKPESYVFRGRDDDWIKSQNSLRCDTKAIEDNVRMTCADLVDECVVVGNGRPSPTLFVEPKTNGVNEDRMKRDIIRRTRHFHARRYLHERITSTNFVVVVPKGTLPRTATKGNIRRKAVEEAFQEQLDQIYRTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2G7</accession>
    <name>A0A2R6P2G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v5439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000534">
        <property type="protein sequence ID" value="PSR84402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2G7"/>
    <dbReference type="STRING" id="98765.A0A2R6P2G7"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="8">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="7">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR84402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="281" mass="31358" checksum="81AE113BE00416A7" modified="2018-06-20" version="1">MATYSARPSPSAFSTPASTTLFRRLTWEGTVPLEIRVDSKELPANSDRGLECYYIQAPRVSYLPLLVPELKRFLMDVVFDEAAARVIKEEDWWFESEDGTLLKWHWPIGLIYDNHTILSSARTAPSSSHSMIPLRLILHLASPPTDKLLLSPSTEACKQAFMGQMKEADFIRWGNTKRMTGLRKAEQDGLWEGIKEHSFDEYWRVAAKITPTTTPTRSTSPPPAPSSTSLHSRPPSVDPNTGGGVPDRDGAYNVRSVPVRIYLPDGPILQDLVPPTLDDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5K7</accession>
    <name>A0A2R6P5K7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5K7"/>
    <dbReference type="STRING" id="98765.A0A2R6P5K7"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR85869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="820" mass="89614" checksum="5DCF742BC023A58F" modified="2018-06-20" version="1">MQQQSQQQRKRSFLQGVASIMAQRGTPLPPALTGAPYQGFDPATSMWRSLEVSGVDVGVVRLAGKDVDLFKLWALVQHHGGSTKLSQQVMWGQLLPQFDLPEQYMQPNGQPQSSAVALERYYSRLIGPFEEMYRKNIYRDRAMQAARNQPGAPGTNQGRPPGMTGTFPPVGSLPAVSGNNGLGMMGQPITGGSALPTEVSLGGIGGPQFPASQMISQAAHMSQQQPISGMSGTPDSRVDVAGTDSLSAARQDANGIISSASQDSELNGTASEQDVDGRKRKMEEGDEANGKRVRHKTGESSDLRSSVPPSGLTPHGMNIASRPLRQPSRRRIEYIPLAREVDTAGGRDLDAIQSEFATASQRPLKDLNEWGAVDVEALTMSIRSRISTELSYALTTFTILTLMRIKDSGFPVVQAPDLLDELLDLIEDVAFEGMEDIDPDDFPNSSIITHRHLMNAILEEGSQPFASLKPKQGLRDPGSGPQQRPGDVILTALNIVRNLSLSAENQDYLARHSRLLGIILRLCSLKNPVDLLYPAPLSPALSLNDLILARKDVIYILVNISATVQLSSTDSPSSAVRNARRAFDLLASYLVDPVDAVPPLQCLLLNGAPTHIHASKPPSTLDTALEAFTRFTHPDDNRLVFARAIPPEWLWCMIEALVHRLPVTDHDFQVMMRAEWLAYLERIVLSLYSIGFLAPPKVKKRVKTDRQLAFPTVMLRLIRKLTIGSPADARPHFVVSVRRAIEVIKLIDDAGDSFDTSSSTMPTLAFGMGYGEHGETRVEKGMGLLSGHQDEVTWGLMMSRDVDDQMFSELSSLVRVEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8J7</accession>
    <name>A0A2R6P8J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Polyprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">PHLCEN_2v5279</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23 31">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000520">
        <property type="protein sequence ID" value="PSR87021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6P8J7"/>
    <dbReference type="OrthoDB" id="3251181at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="598"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="350"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="852"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="864"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="909"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="PSR87021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="30">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1309" mass="145369" checksum="27B69EBDE11A7322" modified="2018-06-20" version="1">MSSTDKLGEDYLRVPRLDVSGSNWIIYKDRLQFAADARGYLDHLDGSKTSPIAPVSPTPLLSSPAPDPKAIAAYEADEKKYKEDLVTFEKDETKWKRGEGIMKQLIAGTIPDSLFIKLRHQTNARNMWLALGSEFQNKSRMVSVDLRRRLQDVRCGEKDDLQTHFLKLRTMRENLAAMGHPPADDDFYAIILGSLPPSFEPYISAVTATSAVLGTTLSAEDLMLTLTEEYERRLLRSKNTPSRKEDTGDAAFTAAEKGKGRSKRNIECFNCKKKGHVKAECWAPGGGKEGQGPRKGKSKDTAAAAKEEETSADFAWMANAEANVLEGLSSTTGMEPLSVDDYDEWYPEDCASTASSDSIPSLDTVSEDSEDTETDWPHVSNVPDSAEGNIEDVEGAAYTLTFEHALLAKESSAACEFETELYDSGASRHMSPYHHRFLNFQSITPKPIGAADNRTFKAIGKGDMYVDVPNGETTSRVLLTDVLYAPDMGVTLISISRIDASGSSILFKSGKCCLYNPVDDLVGEIPVVDGLYCVYHPKHIDYAGQVKDVLTVEELHRRMGHISYDAARHLIKKGLIIGVVLDDTPPAGPCAVCDAAKATRKPIRKEREGERAAAVGGEVHSDVWGPSPVETLKGRRYYVSFTDDHSRWTVIYLMRTKDEVFRHYQSFEALMETQYGTKVKILHSDRGGEYLSTEFSNHLAKQGTQRRLTVHDTPEYNGLAERLNRTLITKVQALLLDSGLPKALWGEAAMHAVFLKNRSPTRALSDTTPHEAFLKRKPNLAELHRWGSQMSVHDPSRTKLEARASVGHWVGFDEQSHAHHVYWLHRRSVTVERSLRFDDTVDPVFADVPLEGERALEDPGGPDSTGTPTNTSNRPKNHQETAETSPEPLISPSPGSPDVLGPIFEEIPSEGRGKHVRKPSDYVRRLRGGEGSVDGKGDGNNLPKGMPVVAEGDTAGLAWVTKVDVEELAMAAVMGDAEGLQPTLEEARKRPDWAKWLAAIKAELESLIRNDTWTWVLRIKKDATGAIDKYKARLVAQGFTQVYGVDYFETFAPVAKIASIRLVLAITARDGWEVQSFDFNSAYLNSVLNDDKEIYLEQPPQFPLKDPKLHVLRLKKALYGLKQGGRKWYEHLCIALADLGFKRAEADYCVFYTKVGESLVLLAIHVDDCIITGNSSTLISQYKRQLGDKYSLTDLGPVSWLLGIKVTRDLEARTLSLSQHAYIDSILARFNFTDLKPSSIPMDPNIQFLKSQCPMSLVDIARMRKIPYREAIGSLMYAAVGTRPDISFAVSTLAQFSHNPGWIHWEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8L4</accession>
    <name>A0A2R6P8L4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000517">
        <property type="protein sequence ID" value="PSR87145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8L4"/>
    <dbReference type="OrthoDB" id="2739065at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50234" checksum="5D7F6AC49A10FA1C" modified="2018-06-20" version="1">MSGQVVESAHTSLPPELTDNIIDLLCLDKKSLSSCALVCRSWVPTSRRYLFSYVALRPDNSLNEFLGFIAKDDIDPWLGHPVSGFIQHVQIATPSPRLPGFRRSVLTTDIVNSLLSILPNLLHLHLMHIELCWLSPLDPDNETVIDRPIHLESLKLSFVTCPTLIDFVYSLSLFSSIKLLHMSKIKIPMVVRRGVQLVVVHHPSLSGEESHFPSHLKISSIEYSNCPETPPSLLASITKTASVETLVDVAFLCDGESEVNRMGIRCSYARSLVRVFIKFGNTSLGHLTIPISLAAGHLPSRVLQRFNLTACTTLKNITLRMTTIRRYFDLDHDISWGFFPAAAELLSLVPPSVKTVTLVILIGGTCQLLNKFLEVIAESKLLQSAIGQKQGVFEFHIHLTELEAMDLGIRKRREGEEELCRVIRSQLCKGIQSQLAELDAQGISLTLSCDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC84</accession>
    <name>A0A2R6PC84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v4995</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC84"/>
    <dbReference type="STRING" id="98765.A0A2R6PC84"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="15">
        <location>
            <begin position="17"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="34"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR88846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="453" mass="50214" checksum="9112B58075680FCF" modified="2018-06-20" version="1">MCPYSLLYLATLTVEVRVITDRYALPQGADATKCDPANQTWCGGTWNTIRENLDYIQNAGFTASEYIDSLSVSGSKGSLSRLVWISPVSQNYEGPRSAYGDAYHGYWIADATQLNDRFGTADDLKALSDEVHRRGMYLMVDVVVNNVMSTSLTPDLSTFMFKEQSQYHTYCPVDYSNLTSEQNCWLGDDKVPLPDVNTQDSTVVSGYTSWIKTLVETYNIDGLRIDAAKHVNVDFWPQFCGAAGVFCIGEVFGDDIDFASQYQGPQALDSILQYPMYGALVDAFAIPGPQNMSAMTDMIAQSKAKFKDPGLLGNFLENQDLPRWANISVDVQSLWNAMVFSFMSDGIPIVYYGQEQGFAGNADPFNREPLWPSQYANTSTYQFMTTLNTLRNFLVNSTDNWLNSSMEVLTTTSNGLSILKGPVISIMTNIGSPPQNISVAVYTPYESNLATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG89</accession>
    <name>A0A2R6PG89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000495">
        <property type="protein sequence ID" value="PSR90488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG89"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="215" mass="24718" checksum="2DB0A03C194F5DC3" modified="2018-06-20" version="1">MSNCFQALGSVDPPGVVQYLDPIFTPRSARYSSKELFYVASLPGFTSLPRQLVPDGRRALQPPVYLYGWEIDRAKLGEYAEENNLREFVEKTVWLDEDEDEDDDKDEDEDEDEDEPKTRIIIAENESRTMLNVMYSLAKDVGLRLRPQCPLGSVLAQGTMVSFFALYSNYQLANAPLKTEIAALQDHLRACIGETEPPKWLPDDEEFQWRQLYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG95</accession>
    <name>A0A2R6PG95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG95"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015357266" evidence="1">
        <location>
            <begin position="17"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="245" mass="27153" checksum="3C23A1C8F9784B9C" modified="2018-06-20" version="1">MFKSMLLALFVSTVLAVPAVKRENLCNVHSVTLEQRNRHPSCYSSCKRPCVHRSRRGCTELYVYHYWNVGALAELFDISCISPSYYDDVTDAAWFVWEHAPADLTAAEVIAGLAPYHLKFVLGQHYFITNPITGSGLSPKWDFTSASKAGNANAFVVGARTGDIPSPTDPAVNIDWLSLSGVQGDLADQIFRVQTRGGQPPTSCTPGSKEIGVRYVSQYSVAHVAPIYYHKIYHKEARKRGQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNJ9</accession>
    <name>A0A2R6PNJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000447">
        <property type="protein sequence ID" value="PSR94552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNJ9"/>
    <dbReference type="OrthoDB" id="2755641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="154" mass="16724" checksum="2D28A1B9C5C98CC0" modified="2018-06-20" version="1">MITDVHDLKNGDQQWKSAVGDVEQALILYRKAKADGDTDVKTKLEQEIPHRLRAAGDCAPDPETRAKLCSGADAFEKGDEKSRWEMIHPLLQGLAILLATPFAVAGVAIVASGTILYGSGKVLLGFGDLLTAGPVMRWKRRKAEAKATKKEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNQ7</accession>
    <name>A0A2R6PNQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD linked oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNQ7"/>
    <dbReference type="STRING" id="98765.A0A2R6PNQ7"/>
    <dbReference type="OrthoDB" id="3222453at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD linked oxidase N-terminal" evidence="2">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR94669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="354" mass="38584" checksum="9F058143D46604A0" modified="2018-06-20" version="1">MRYGGFQLLFNAADPLGERVPGLDVPNDFEPTVIGIGPVISRLRRNGVLKSAHIKETQIEASVSAENVPIFPTSAKAKLEYSFESSVSEGALLATKYETRCVDAQQLGTFRKYILAHYKSWFQFANCPDHDHGIDVEDLLFVTGCDMTADFSMLAFKHNKEGQQVRFELGAASIASASASWGTWQCQSPLTYENWGPQTLEDDAGVPLDGQKYDQCIFLRAFGVARRAWILPKVIKANAGPHDPGLGERRGDQPPLLRANIQDSGDLVDSVTRLEVVSPTLALPCPGSPPTVVVYPTSTEDVVHIVHIAKKYRMPVVPYSGATSLEGHWRAVSPSPFSPSPFSPSASPPSAPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVP5</accession>
    <name>A0A2R6PVP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000432">
        <property type="protein sequence ID" value="PSR97711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVP5"/>
    <dbReference type="STRING" id="98765.A0A2R6PVP5"/>
    <dbReference type="OrthoDB" id="2789130at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="143" mass="15921" checksum="E5267C958C48421B" modified="2018-06-20" version="1">MEKVFLGLVAGGVEDKVVIAVRALLDFVYLASLQAHTSVTLAALHQSLNDFHTHKQIFIDLGARSPEHFNTPKYHMLEPYVELILNFGSADGFNTEWSEQLHINYAKDGYRASNKKDYTAESAFKYRDLRLVNKTSGLGGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYV8</accession>
    <name>A0A2R6PYV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYV8"/>
    <dbReference type="OrthoDB" id="2537480at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37423:SF2">
        <property type="entry name" value="MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37423">
        <property type="entry name" value="SOLUBLE LYTIC MUREIN TRANSGLYCOSYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglycosylase SLT" evidence="2">
        <location>
            <begin position="180"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR98913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="294" mass="30377" checksum="00F081C70611F86F" modified="2018-06-20" version="1">MAKDEMLMRPGTVSPRPDVPRLVDGAANLEIKERGQPPQPALSAAGKFTRCYHFSRIRQATTQAPAPTTSKAAAAPTKNAAAAKPTTSAHAAPAKAASAPSGVNQLTTVAPGSCGASGATLDLTAQTGPNGAEWFFNCGIDGAGWNPPHMTVDDVVAKDLKAAVAQSNSPFTNCAAYIDLFEQYGNQFGVPPIFIASIAMQESSCDPNKTGGAGEQGLMQITKDKCGAAPGGNCKEPWYNIMTGAQFFSGLINDNDGNILLAIGQYNGWSKGMTIAKATAAAHTGCCPCQNNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ33</accession>
    <name>A0A2R6PZ33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000421">
        <property type="protein sequence ID" value="PSR99304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ33"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="92"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR99304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="882" mass="98692" checksum="B3296C638AA6778B" modified="2018-06-20" version="1">MDPWQESNLSKNQPIRKFEKVAHNVSYSQISDGSSTETQVNVSIVLLWNLLLMDESAHSLSMSITPPRTPGQVVTVNDEPILCKVVGHPTGWAAMAKAIREVDVAKVESHKDDLDNLLLFAGLFSAVITPFIIESYKTLRTDLDPKSSFELLQQIAGQTDSYTIITASGASMFINSTDPAPGSQPFKPTHDDVQVNRLWFASLILTLMTASFAIFVKQWLREWIYTDYTSAKARLRIRHFRRPGIEKYRVFEIAAVLPLLLQIALGLFFIGLCYFTSPIHPDLVRISIKMVAVWTLIIGITIILSFIFPQCPYKLVILNSLFRWLRVSARGLRKHAKHPPDFHEETGVVDREDNDLDILVKVDSIQADDQLLTTAIKDCVKQINPPPYQIIDFLLASIAHRARIEEDELRTSPFDLTAVSIPESVWGMVAQLSLEALGDRRPNQNVQRQGNQEECRIISPCFLFVSALHFPVQRPSPNSSDERQYSALKKHIETEPLEIGRAFGNIPHNSPGTGKRVLEVRTFKDILLGSLLSVILEEIEPSRAVYFMAGLLDTRQHIWRKEPDMFSEKFETIETQGTFQSGGGASTSEYPQTQRVSASGSNRRLSSPNSKSEGSLLSAMLAPVLKAYLQDLHHHRRGIPEDDVPVFFKAFKIILYQANIPDGAENTEDGGRVDSNEGNRAQDVAVKEILDLYIGLGAEQDHWLENQRNPMTLLLDFLLGQSIQVGVPDGETMTLGCAILSWFKNLQGDWSHGFCEMAFHAVSGLHRRGSIGASLFDALHEAIKSDQAQSRELRRRAVARTLGPPLAKNPRKAVAKGCLTAIDTCKRLVSESLHTQETDTSHYDSRISPSFCDDPLIKTLRDMSNAENGTWRVKRPALDSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZP9</accession>
    <name>A0A2R6PZP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000424">
        <property type="protein sequence ID" value="PSR99178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZP9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR99178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="167" mass="18498" checksum="20BC324C1FD101F1" modified="2018-06-20" version="1">MLLEHSTPSFAGPKLQANKPLHAQLDKLLALKQDAVNTGVTISDQFEAFALLWVAPPEYSNAITLVLQSKDIANITSKQIIDTLLQEESLRATSAVAGCVSNTTNKPKKRGLCGKKGHLQENCWDDPKNAHKRKGKGKPSNDDTLRPRYYPNTQHNPSRLCCSHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7H7</accession>
    <name>A0A2R6Q7H7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000388">
        <property type="protein sequence ID" value="PSS03337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7H7"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7H7"/>
    <dbReference type="OrthoDB" id="2800779at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="195" mass="22239" checksum="4CFD597DFFB3C580" modified="2018-06-20" version="1">MHPNDVPNHGLDDPEGQTPYLNAHAMMNAVIALGQHQGQFAEYQAQANGLLDTLTQWLVDPQLQPRPPLPTGQVRFHEPRVFNGKAEEVVPFLREIKNVVHLQHRVLLDAYDKVIYMSTYLKDGSPSSWYNALDVRRSPLLFNFKGFVEDFKHHFKDSDLVSSSLRKLKNLHQTGAASSYASRFKELLVYLDLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBJ1</accession>
    <name>A0A2R6QBJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBJ1"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="649"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="857"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="707"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="877"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS05485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="890" mass="95335" checksum="792F918FCED4A563" modified="2018-06-20" version="1">MTTDGGLERLVRILHDFCMCPPPPENAAILYGLSSPSAHITKLAPTLNPKSFDKAAALRFSLAFQSVVNIGVRGSELIRGRVVQAGTLDVVGCILEAWLAGKGFAIGPGVTANGTQRETREQRIARRQAQQEIRQREQATHLARALQRQAERSTTEGTIRATRTTQTLDDDTMDVDMSSSEGQAGSRDTDTSTEPSSNVTPLGSNTPTGAVLIPNRDRSGTVIARPVWDQAQTATAAVHHRRNYRGVSRLPVPPASEGPSTSHSTDTSRPDTETEDDGDVDMDHDSTRESDAPVSGASSPDRRNPSPDASTIRAAATHSRRAVGIVSDEPNTAGASLDLNSDAHIIINDQGVAVDGVGVEDGIVSLETNDDFAMGAPPGAPGAINGPPAGRQDVHTGAGERTPRAGTITLPATTPTQVPPVPATAAMRLRNAEGGTVPDQLQRARLHTLGVVPTPTRGVGAGAVLPTHHHHHHRDSDAGPYRDEDVLLALQLLAYLSKYPHVRQAFYKPRPSFHPATVQENLADEPAWRASAGPSTSKQPAAAPAKESNSFLKAFASAAGRGKEKEKASPSISLSSSSSTSAPSANAVPRMTNVFSLVERFTYRPSSSEVEAPTPPPTLPTEIQYWAGVIMRNACRKDDSRGGIRQCANMMCGRWESFPREFAKCRRCRKAKYCGKECQSIAWSEGHRFWCSAKDNDEDPDNLPFDSSSRAGSSASGSHSLLVTAGGTVTGRAERRAAREQERQARHADEVPVRTARIAATLAQPVVPDTPTTDPQRVRPAANNQGPLHWAFSPLAMRRPRTRADDGALNPNEPQAPRAQVTRLRRQGENAQVDIELAPEVRRQLVHIIQGNRRPERIEVATGTADAGPSRIREAGEAGEDDGDEAMVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEP8</accession>
    <name>A0A2R6QEP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEP8"/>
    <dbReference type="STRING" id="98765.A0A2R6QEP8"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="268" mass="29509" checksum="33F1AA85D669977E" modified="2018-06-20" version="1">MACEHCTQGYIVPGQPQGKMVNGAYFHPAPQGSTTKSRAIVVFTDIFGLPLKNCKLIADALSSRVGCDVWVPDLFEGKPPFTTDELVPILPDTGKPDDRMGLLRKLRLILLGLSRALRLYRARPAVVDARAIAFLKSIRKERMYETVGAVGYCFGGALAIRLGSGNILDSIVVCHPTHRSLSTIQAINIPTSWVCAESDTSFTKDLRDESERIFAARKNKPEYVDYEFKDYRGTVHGFAARPNIAISGLLEAYQGALEQAGAWFDKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QES9</accession>
    <name>A0A2R6QES9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QES9"/>
    <dbReference type="OrthoDB" id="3364886at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="6865" checksum="69F43EDDEF515F07" modified="2018-06-20" version="1">MESAHASLPSGGLRFLKGGLVDCALDMPLEIGPKAFIALWVLSAIPCILLAGRWKYAAIILAGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIP5</accession>
    <name>A0A2R6QIP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000340">
        <property type="protein sequence ID" value="PSS08867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIP5"/>
    <dbReference type="STRING" id="98765.A0A2R6QIP5"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS08867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="441" mass="47118" checksum="F257ACF04C948520" modified="2018-06-20" version="1" fragment="single">LLSVNYAKDIGHWATSSTDVAACSVEPGNAADVGIILQILGSTETPFAVKGGGHATNPGFSSTSGVHIAMYRFSEVTYHADSQTVDIGPGLIWDDVYTALEPLGVNVVGGRVTGVGVAGFSLGGGYSWLSNQYGLTVDNIEAFELVLPNGTVTTVDSGTPDLFFSLKGGYNNFGIVTKFTMKTYPQGQVWGGLITFTADQLSKVNDATVNFSTNIVDPKAAIITTYNFLLGEPGVSQLIFYDAPTPPEGIFDDFLAIPFFTKDISTRSFLSLVQSSPANATSNTRAAFNTVSLLQYTPNIMKAIVNESIFWGTQLSLASATFISYDVEPFLPAIFQQGTDLTSAYPPSRAPTLLPLNVYFAWELPVFDALMRNATRLSAQQLTNVALAEGQDIADAALYGNYAIDGTPLERIFGNNLGTMKATKAKYDPDNVMGLTGGWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIT5</accession>
    <name>A0A2R6QIT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000328">
        <property type="protein sequence ID" value="PSS08899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIT5"/>
    <dbReference type="STRING" id="98765.A0A2R6QIT5"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="3">
        <location>
            <begin position="146"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS08899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="381" mass="40936" checksum="71710C50B73576A7" modified="2018-06-20" version="1">MAPIRLGFIGLSSKGWASISLAPPLFDPLLASSYSLTALCTSSEASATAAVAKYSELAGHPVKGYHGAQGFVDIANDPNVDMVAVAIKMPQHLNAVWPAIEAGKDIFIEWTVGSSFEETLKIAEAAKKKGVKILVGAQATQAVFLNKVKEFIEGGKIGRVLSTSLITTASYFGSTMSESMAYTLDANNGADLLTIPIGHFLVALSHAVGDFAEVSASAINQYPVVNLTDEDGKPTDKIIRKTIHDQIALSGIVRGHNKNAGAVFATFQFRAGIPLDGERERGRTIFKWTIDGEYGTIEVQHSEEEGTAGGFIQMREKRVFLNGEEVKLELGEEDRLGNSGKAWLEFARGGRYVNIDDAVLVHRVLDAAQKSIAEGRKVVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUH4</accession>
    <name>A0A2R6QUH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000311">
        <property type="protein sequence ID" value="PSS15392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUH4"/>
    <dbReference type="OrthoDB" id="3172613at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS15392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54017" checksum="CD4A48BCD0AF9ABD" modified="2018-06-20" version="1">MHSRSQAAPPSSPIQIDEVLRHVRSQPGVPPGMPFRVLVMGRANSGKTTILRRVGGAEDPLVRRFDQAPPIHKKAFNLLRSQGVSPKDAIRQAPSRARKFFEEELRPRVQQTKYPPSRCITLSDPYGSKSIAYLVQYLVAWFCVATFDRTDDKVLPLIARITKKVMDTRDGIGNHKYEYWDPSNFHAGWTLAGSMPRTDAEHDVVANIMVLTASMSSLKSLRLSHTFLTHLPIPAETLIILERASWEKGLLATKINIALRSFDRSASRISDAIDLAVSGGFKEQTTEEQRVKWLYGVVCKNLLEPPDDSTSSLIARITKHVMDVRPGKEYRYTFWDLAYCYAGRSLAGALLATDAERDPNIMVLIASALQLTRFPCATYRRTTEILIVMERASWERGPLATKVDIALGVYKTSKSRISRNIESAVSRSHENSTSRRRKCKESSGYTELCAIANQVLTTEERHTDSATGALSRGSQLDAGYYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7B4</accession>
    <name>A0A2R6R7B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7B4"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS22661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8145" checksum="4FA81CBB941501C2" modified="2018-06-20" version="1">MAGTYLKRDPAIDSFSLLYLRPYTTSPKTKTCVHLALVVFTEIAQPLIPQRKWDWKGKKKGESLRAGPKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI52</accession>
    <name>A0A2R6RI52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI52"/>
    <dbReference type="STRING" id="98765.A0A2R6RI52"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS29668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="225" mass="25676" checksum="361088A84009EAED" modified="2018-06-20" version="1">MSSDSSSSDASTFERWRRRFGVMTGVGISEQERLAGLEAHRGRTCEKWKKELMHYSPSVVFMLKHLKLSGCNVTPDNIVCSPCDMSRSGGFSPQAGAIVMCQSHFFSKRHMEDTLVHELVHMYDHCKFKVDWNNLRHHACSEIRANSLSGDCKYTRELRRGFVSFSKQHQACVRRRAILSVRANPACPDDATAERAVNEVWESCFNDTRPFDEHPTVQSFARSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIL8</accession>
    <name>A0A2R6RIL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000249">
        <property type="protein sequence ID" value="PSS29854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIL8"/>
    <dbReference type="STRING" id="98765.A0A2R6RIL8"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="288" mass="30875" checksum="E7F93DB0A7315E9D" modified="2018-06-20" version="1">MATGWKQLQTGFATLNLGQSANKFARGFNSSVQATKERLGQVSAGEITELPQGVITRVYESETYDYPTAIQESLTELGTTIGQGITNFAAANLKGTNLPAPEPATPGVAQHKTLPHALGRAATTAANAMQESSPASEDKLGKGLAHYAASWEKIADARVQQDETIKVHFLQPWQTTLSTSIAVAMKARQAVRVSRLELDAAKQTLKNAGPAKQEAARIEVENAEDDLVQKTEVAITLMKTVLENPEPLKNLNELAKAQLIFYATAAEALSTAQGEIEELSVAAEGEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLJ1</accession>
    <name>A0A2R6RLJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000236">
        <property type="protein sequence ID" value="PSS30897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6RLJ1"/>
    <dbReference type="OrthoDB" id="3020460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29993" checksum="034E7BDE9BBC3708" modified="2018-06-20" version="1" fragment="single">FSSSVVIWPASAPFKGVIRVLKEYKGPLIAHKIRIGPNYQEDLKAMHFLGEPLGVEVKAYDPYTLSPLLCPSLSISRRLPRTPHTLSLLLLQDPPRLLRAQHIQSLTLDLCNEMENAFKLVHFDTDAQTARPTYCPSGITTRSFAYGLQPPAIQSMLYFDHSCGRDSVATMIYPFGPEVLLGMMDDSIIAPKLCHAGAVGYVSKSGSRSYELNGPGVLPFVTSGTHEGIAIGGDRYPGSTFIDHLLPHENDPECKMLVLLGEAVVYRVIEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLN7</accession>
    <name>A0A2R6RLN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000231">
        <property type="protein sequence ID" value="PSS30944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLN7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="165" mass="18304" checksum="F0B7621D7E257A1D" modified="2018-06-20" version="1">MSAVDLQEDLLNAISSPLTPQITIPTLLPSFPIKTSESHPIKTLANHLFASVQSKPAITRAVSYPTVVSASPSPFVLSTSPSSKRMDPWDRRLSHQPGPFYTFAETCEDTRFSRFALESKTCTGSCHLKNQCGPETQWKIYDILFGLNCIKRPQNIQAAQTTKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLY4</accession>
    <name>A0A2R6RLY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA processing factor 4 (PRP4)-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000222">
        <property type="protein sequence ID" value="PSS31022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLY4"/>
    <dbReference type="STRING" id="98765.A0A2R6RLY4"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001211">
        <property type="entry name" value="CBN-PRP-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="211"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS31022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="515" mass="57569" checksum="6BA74416B8AB9C3B" modified="2018-06-20" version="1">MSELTFDTLIDDGNYLGTERAKLENKLLLDELERKKKARSLAVPTDDNRVRARLREIGEPITLFGERAADRRDRLIYVISQINAARGEDSMQVDEESSDESEDEVEEFYSPGSLELLEARRRIAEYSLPRAQKRIAQQRIDSKMPLGRIIDIRKKVFADVKNFANLGSQIGDERPISQVRFSPNSKILATGSWSGNVKLWNVPSCTPIKTLRGHGDRVGGVAWHPQATLTQSEDAVNLVSGAVDMNLHLWSLNSETPLATLKGHQDRVCRVAFHSSGDYIASASFDTTWRLWDVNTHKELLLQEGHSKEVYAVEFQEDGALVASGGMDAIGRVWDMRTGRTAMVLDGHVQAIFSIDFSPNGYQIATGSEDDTIRIWDMRSLKALYTIPAHLSNVADVRFFYAQDAPVFTALHPPTHTKDVDMDATQDKPSADSKGETNTATPEEQWKYRSGLYLASAGYDGLVKLWSADDWQLLRTLPTDGGKVMSVDLSKDAKLLASGTYNRNFQMFAPEELPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM17</accession>
    <name>A0A2R6RM17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM17"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="116" mass="12587" checksum="B51588CB7B449C22" modified="2018-06-20" version="1">MFMDESKRSSSITESADVLVDENGMAHVLGREKGEEFVDGQTAEQVQPAGSTSDPYHIPDGGLRAWLVVLAVCTTRYFTLNNSTSADTVTMQSACATFTTFGFINAWGVSKQRIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPZ5</accession>
    <name>A0A2R6RPZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000198">
        <property type="protein sequence ID" value="PSS32094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPZ5"/>
    <dbReference type="OrthoDB" id="3270380at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="349" mass="38870" checksum="71635767AAA74DB7" modified="2018-06-20" version="1">MVEKFSQSFWFSNVFELRLLCTAFYRVLANPSTPQSVMLAVNNGDGFDPRSLVKPSLIRLPPEVLFKIVGGLSTSGLLALMRTSKRCRLFARMEMMEYIYKKLSGSIPNVMEFLDTMRRYEVVISGSFVLNIIDRGAYWNPSDIDMYVPYDAWYPFILAMEEIHNSVAVAPDTESAMPEYLFAARSIDKVLRVVIGSVSFDFVRSASGCATTPIASFLTTLVMNYISADGLCIAYPSTLKNTGVLTRTSLTDGENVAVTKYLGRGYDIFESQSVLYASQPSLAHSASLCGETERTFVDKYCIIMPFGLNKLEDGPISHTNTVWRLGGYGCDGEHEDFAETRVWEISGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVD7</accession>
    <name>A0A2R6RVD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000172">
        <property type="protein sequence ID" value="PSS33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVD7"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="735" mass="79693" checksum="CACCC7D2D4C5D1FE" modified="2018-06-20" version="1">MAKTVQKKKQTMAPPPRLSTRARNANAHPGLVDISEDENPEKTQRDSKRKAVRAKAKEQKEQKDANIAEMEQLIAKLQGEIAKRDALEVVNKRNNTEKQPPSGSHPSPSSPIEAIEEPLAPPSSPIEEMFEDTLDGDIVMSDCDGGPGSKILLVDAFDGSQSPSNSEIGIAGDIEPEEMDTSMEMAPAAVVPGGPLRRSNAAFFGRNSEGDVVALDRRSPVDNSYALDMLPLRTDQPKKRKAAVHEDDLPEATGGRSSTTKLNHNGSGAKAPGGVKQPANVKPAAKKVKTNTPKGLVMNWREKIVGGSSSPSLHSCSSSSSLAANAVDSDCSQASTPMAITSNASSPKKAVSAKLKVAARDTSLVSVVAAFNHFKLNVDLLQMNVSAVSSTSKPNVEAHANLEKPEPEPEERRLGRTPGRFSIRIASVPNGELAVRRRAVRRGPLMVDVPLPNVPGGRAIWRGQVVPSYIHFVATLNNPWDADSTGEEIDALQQSWSAGFPNHQQVVTAASPMYKVALQRLYEWRSTVGKRGIAAVEWLWSERKLETKEERCEYVATHLGPKFLCMYHDDTDGKGAFRSEVLMRTFAAYLTQCDPTAGSLVDFGVPIGGLAMCAAAVERGFLLYQTGEIQSDKEQKAEIQATLDKGNTQLAKDLKAFHIRLKTFSEPGWSKATQEYSKVIDKLSERAWGGIIRAGMKHVKNSKTLKKRAEGDDEEEEDNRAMMIVDSGYSSGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVG2</accession>
    <name>A0A2R6RVG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVG2"/>
    <dbReference type="STRING" id="98765.A0A2R6RVG2"/>
    <dbReference type="OrthoDB" id="2538110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9342" checksum="3FFF04B89A48B67A" modified="2018-06-20" version="1">MSSSGKSTDVKSARPTSRSRLEPTSDIDELHARLQADPRFNPPTPSPWKRIALLLVVAILLWAGVTMRKPHAKASQIVHAKRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVI1</accession>
    <name>A0A2R6RVI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVI1"/>
    <dbReference type="STRING" id="98765.A0A2R6RVI1"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="311" mass="33397" checksum="4A86C19395F2DA1E" modified="2018-06-20" version="1">MAAAFFSLPKQFVTVYLGVALEQSDDGKSNKLDNILKYVVIVVTGIVTFLAMYYINRLMNGVKPAVIYDRRKARQAKLPSAGASSGPYGNSNVFKPATSGAFNPNASDSDMPLTANFNESSYQQWDSNGRAVGYAPDPMLYAPQPQRPRVPQSASRAGSNAPTPVMSEYNGSRGPPSRQNTSGSAASWDVQTHAGGADAYQMSRASPYTDPYSNSTRVPPPQIQQMPYSQSPPPIHSVAPTSATAPVTPRIPPPEQTPTQMQFASYRPPAGLPPGAAQPYQPHSPHSPLPNPYSRGQESSDDPYVAYTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW08</accession>
    <name>A0A2R6RW08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000143">
        <property type="protein sequence ID" value="PSS34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW08"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="10118" checksum="79F12A5C46043668" modified="2018-06-20" version="1">MARRARRTQAAQQASEEARQADYQCFLQQDEHMVWRQWVAELEELNGQAEKRRHLRKKCRLAQQLLMVDPDFTVLCSGRKVCCMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZB8</accession>
    <name>A0A2R6RZB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000135">
        <property type="protein sequence ID" value="PSS35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZB8"/>
    <dbReference type="STRING" id="98765.A0A2R6RZB8"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="352" mass="37210" checksum="C3BDE6EFD86F3121" modified="2018-06-20" version="1">MEDAGERLGPVGNISVERAVPHLERRGATETPGALKSAEFATRSFSNVTNIYSNVSPSARPPILEGVFAIDLGKSSNDLLGKDFPFAGTALEVKTSTPSNVAFKVTGNQNAKTNLINGELEAKYTDKSHGLVFTQAWTTANYLRTQVEAENHLAKGLKFDLNASLVPDGAGKTALFTTTYKQPGLHTRAFLDLFRGPTFTADTVIGRDGFLLGAEASYNVTEGKVSRYAAAVGFSAPEYAVTLHGLGNLSTFSASYYHRVSPDVEAGAKAIYDTKATTQGVSLEVGAKAYLDSAAFVKAKINNSGVLGLGYTQALRPGVRASFGLAVDTQKLNEVTPSGPAHKLGASFTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3A9</accession>
    <name>A0A2R6S3A9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chaperone DnaJ C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3A9"/>
    <dbReference type="STRING" id="98765.A0A2R6S3A9"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chaperone DnaJ C-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS36761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="256" mass="26773" checksum="308ED2571E0F37C9" modified="2018-06-20" version="1">MGGMSGMGGMGGMGGMGGMGGSGSRGGFGGMPGGMFGGHNDEDDDMSGAQFFGGGIPGGMPNGASARRRESSPAPSGPSEITRPLKVSLEDLYSGATKRLKVGRKLLNGSTEDKVLEIQVHPGWKSGTKIRFPKAGNEQPNGEAQDLVFVVEEKPHDRLKRENNDLVATISIPLVDALAGDGGKKPIETLDSRRLQVSIPSGIVKPGATTTVPGEGMPIRKEGSVKKKGDLIVRWEVVFPDRLTPAQREGIRKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S436</accession>
    <name>A0A2R6S436_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S436"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="22317" checksum="918C529FEE22D1F9" modified="2018-06-20" version="1">MEKHCCWIYLDGTLNKNGQECGFVLPAKAIWKSKLQGRNPRVVQFTDVLKSICLEQQVLLDVGKSKGGVQIADEPTWKELNVWLVNALIDYGYLKKGSPPQSPYVLGECSIPPDTCSVASDSGLMWDDRAVLGTLRLDSFHIADEQATFDIDAWRSGKYNGYTKTFYIVNKEWHATLNEGERVGANMFPGYKVYSLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4I3</accession>
    <name>A0A2R6S4I3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v1036</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4I3"/>
    <dbReference type="STRING" id="98765.A0A2R6S4I3"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="392"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="795"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS37163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="931" mass="102612" checksum="8F44C79488DE2B3D" modified="2018-06-20" version="1">MIDCIRKGELPPNRYTQYMKQIETNQSYIRKWISPSPINNSAWVALVDAEMASLLNSPDAFKLYDVAVKLSVNNDWLLEEGWGLFLQGSHFIRCGVEGLGSELQRRGISRQSQWGARGIVYHLSSLIDDRSPLPLKRHIFSSDVAVQTDSVLISATPPPDEDIYPQSKSSSTTEEDVINKLTAGDLASILRWSKDISRDINLSLALQRLTEIATENSGSQSTCVVIAREAGDYTVATSMLPPEPCQVHENPISVRAIPDPLQRAVIQHALNTKGRVYLDDVTAEPRFSSEARESPHRSVICLPIFSNRGQTFGAVYLASRYAFSPNTVTVLTLLCEQASIGISNALLFRSVQAGTRENLKMIAAQRDALEAARKSREDALKATKIKSNFLASMSHELRTPFSSFYGLLDILSGTELNNGQREIVTTAKQSCELLLKIIDSILDYSKLEASALKLEYSSFAVESLIADCMELLLPMAAKKLDLSFDIEPKVPPWVTADYARIRQVLMNLIGNAVKFTINGFVRVTCSVDHNTSSTQGEAHLKFIIQDTGIGLSSSDVELLFVPFQQADSSSTRRFGGTGLGLSISRQLVKLMGGAIGVQSQLGVGSMFWFTIPVKICDSEESKDALAEIDRLKLQLMKPHPLRVLVTSKSPATVSLLNTMLSGFFIASVSSIEEAQEHLRNATTIHPPLDFVLLDDQSEHRADELARFLQALPADTLKDTKIIHLYTPTTDSLSGHSAFTNDTPGVVRMTKPPRSGRLLQMLAVLKNPSQNKIIPSGGEAQSEDQKLAENRSLFGNVLIAEDNPVAQKLLIKQLERHDLHVIATSNGEEAVTEWESHEPGYFSVALFDHHMPICDGVEACKRVRVLENKRRVPVLLPIVALSADCQESTKQLCLSAGMNSFFSKPLKKSDLYSLLCTFGTRPVKPPDDMSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4K5</accession>
    <name>A0A2R6S4K5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase family 44 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000071">
        <property type="protein sequence ID" value="PSS37224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4K5"/>
    <dbReference type="OrthoDB" id="3180848at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024745">
        <property type="entry name" value="GH44_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12891">
        <property type="entry name" value="Glyco_hydro_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015310962" description="Glycoside hydrolase family 44 catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 44 catalytic" evidence="2">
        <location>
            <begin position="312"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="748" mass="80691" checksum="FE2872A3FFDE1983" modified="2018-06-20" version="1">MSGVSRVKALVAIFAITSVAVRADEAVYTDNALASGWQDWSWGSTIVYTATDMKEGISSISVNSTAYSALSLYDPTPFPTYAGLAFDISGAQPDVSIIIQDTADNTQSATIPLSALSNSVTTNNFTSILLNFNSVPPNGVPLGNGTWDRITFQAGGNGAAYYIDNIELISTITIAPEFLSAEPLANNLLAVTTSGDVDFSTVKVNLNGKSIHLTSNTTTVPVDNPSKTITYLTLASSLAPGNLAITAGNSSFSFVLPAKLDATIGHSATHSISERIYGVNFPTSASYIQDLGVTISRWGGNAVTAYNPFGDFTNAGNDWYFENRDSDDGSADDWVGWVSAAGSDTLLTIPALDWVSKDATSYSYPASIYPDQEAFDPYNGVSGDGLFPNGSYVTPVPDQSNVYTPWNTSLAKQWLSGLVNKPTLVAIDNEIEIASNTHQDMHPDPMGYDEELARVVNFSTVAKEVLPDVEVAAPSTCSWWYYWTSEIGFSDNAAHNNTDFIPWFLAQMKSQEKTAGTRLLDFLDLHYYFQADTSANDDAAKALRLRMTRSFWDTTYVDESWIGTDTPQNTQPNATIVQLIPRMRKLISQVYPGTKFSISEWSSTADTDITGGLVTVDSLGIFGKYQVDSATYWSDPDETGPIGLAYWLYRGYGVQFGSLSLPVNIDKFNPDTLGIYAATSGSKVSLVVVNKDPSSPVALAVSSLPTGKYFLRHFGGQAGVAKFQTTISLTSASYLVVPAYTAVFLQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5E6</accession>
    <name>A0A2R6S5E6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5E6"/>
    <dbReference type="STRING" id="98765.A0A2R6S5E6"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015340859" description="WSC domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="368"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="589"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="702" mass="72900" checksum="9954656DC3C4C1B2" modified="2018-06-20" version="1">MFSFSKLSASMALLAAAPYVSASSHMIMGGLSPIAYERVDSIVNPGTVSSHVHGIMGANNFNQNSNYSSLRDAECTSVPFQTVDHSAYWAPSVYYQDQNNHSFSLMPSTFNIYYFFDRNGPNETVHAFPEGLKMLAGSPVRDTYNASNFADQAVSFVCLDYSGAVSSNPAYAERQDINFPNVNACEDGIRYQVFFPMCWDGVNLDSADHKSHMAYPVDNYNSGTCPSSHPVHLVGLFFEMLIPVSGYNYWGQGAYVLASGDPTGLAFHGDFQNGWDVDVLQDAVDNCHNMNGDINLCQVLVPYIDEVQAGACTLDSEVVNENVGLNGSPLAALPGCNPVRTDFSTPATCPNAAAVPNFQPTTPPLSAGWADVGCIAEGTNGRALTGATMSAHNMTLNVCAGFCQSKGFKLAGVEFGDECYCGNSFSNGASATTVPSDQCSTGCAANSLYAKCGGPNRLELLQFGGTPAVSSSVAVASSSAASVPASTVVVPSSVVPSSAASTASVDTSGIASSIIASASSVVPSVASSIVASASAVSSPVVASASVSSIASAPGVSSPASVPVAPTSTQILLQQTSSAAAPVSTASAGTWVASGCSVDGPARALTGFSYTDSNLTTASCIATCASKGFYIAGVEFSSECYCGNSFSNNLGQLQTDNHCYMSCSGDMSTNCGGTWSMNIFKKQTAAKRSKHFGRQHHRLSNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5L9</accession>
    <name>A0A2R6S5L9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5L9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10519" checksum="001F19F264CD91E4" modified="2018-06-20" version="1">MTATDGDRLDETFPPFASSLIRWRPRPFFILWYQAQTERYRSMELREEHAPQDVVKTTGEKPVSVVTSCAIGYSVERGLNDNGTCVGKIEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5T7</accession>
    <name>A0A2R6S5T7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5T7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5T7"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="292"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="486" mass="53160" checksum="E7D9B882D9101B3F" modified="2018-06-20" version="1">MGQQQSKKSKKNNKDKDKDAGTESTTPPESVDTDNTPQSSLSRATAPHHSLNSNTLVDGSSSIQVNVTDPDGGVISSNGNGSQPPVPNGSPSSSSSISHNPSSADQTGASISPLSSPLVGNGTKPAPLDIPLTQTILSNATSPSGLPTPGSTNSFSVGDPSYTGNGVLKDKSKVVQVEIDDMIQRLLDVGYTGKVSKSLCLKNTEITAICQAAREVFLNQPTLIELSPPVKIVGDVHGQYSDLIRLFEMCGFPPAANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKTWKTFIDVFNCLPIAAIVASKIFCVHGGLSPSLHHMDDIKRIQRPTDVPDYGLLNDLLWSDPSDTATDWEDNERGVSYCFGKSIINDFLVRYDMDLICRAHMVVEDGYEFWNDRTLVTVFSAPNYCGEFDNYGACMSVSEELLCAFELLKPLDGPALRKEMTKAKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S675</accession>
    <name>A0A2R6S675_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000031">
        <property type="protein sequence ID" value="PSS37772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S675"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9532" checksum="A9E9FC83FEBD15E5" modified="2018-06-20" version="1">MHVNRARNRFGLCKKHGGGGSDCNSEEAVEEHELTSIFIYASVKLLSIMFLVFYSHELTGLLNLKWQHLRTISSITMEHSEAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U7KE25</accession>
    <name>A0A1U7KE25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000253">
        <property type="protein sequence ID" value="PSS29815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U7KE25"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6500" checksum="8D37D14DC625393A" modified="2017-05-10" version="1">MVRFKKEASTIDWKYLLDDAHWAVHQALLAKQDNASPKRSAEDVLQQPRKKRPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDV4</accession>
    <name>A0A2R6NDV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDV4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="12200" checksum="DD2D41AA56FD8080" modified="2018-06-20" version="1">MLLGSTCTFTGKLACADELFHSQTTGAAVECRYALNDCDRLCVMAPACKKPRRFLEFENEKAEGPEDESASAKSEEKVPPAHVLRAGTGRRSGSLGAREISDERPGNLKGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDY7</accession>
    <name>A0A2R6NDY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v13699</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDY7"/>
    <dbReference type="STRING" id="98765.A0A2R6NDY7"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR70448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="826" mass="90597" checksum="803A861949061A93" modified="2018-06-20" version="1">MMLSSELNNESSPPHIRNAAGLALKNALTAREAARQADYSSRWLGLDIGVRGKVKDETLKALGSPHPKVGQVAAQSVAAIASVELPVGQWLDVIELLIGFMNNQSNIPLRVATLQAIGYICESIKPEILTTRSNEILTAVIHGARKEEPSSEVQQAAITALLNSVEFVRDNFEREGERNYIMQVVCEATQNSSVPVQVGAFEVLVKIMTHYYDKMGFYMERALFGLTVMGMKHQDESIALQAIEFWSTVCEIETDMAWEVAEAQDYGEIPENESKFFARTALPEILPVILQLLTRQEEDADEDEWNVSMAAGTCLGLLAQAVTDNIVQPVIPFIEANIRAADWHQREAAVMAFGSIMDGPDPKVLVPLVNQALPILIDMMGDNNIHVKDTVAWTLGRICDLLINTIQPDVHLHPLVSALVGGLTDNPRIIANCCWALMNLADQLDFSENEEMAGQGSPLSPYYEGIIQALLRATETASNEGNYRTAAYEAITSYVIHATDDTIPVVQSTAVAILHRMEQLLGMQNQILGVDDRNNWNDLQSNFCSVIISVIRKLGQGIQPLADRIMTLVLQLIQAAGKTSTILEDAFLVVGSLASALEQGFSPYIQAFLPFLYPALKAHEDAQLCTVAIGVIGDISRALGEQSASYANAFMNVLLENLQSDVLNRNVKITILSCFGDIALAIGPAFEPYLGTTMNVLRQASLLTPNPLDVELLEYVSLLREGILEAYTGIVAGLKGTEKASILLPYVPSVFELVQKCLADSDRSESTFKLAIGLLGDLADTFPNGEIKQYLLAEWIASELRTRTRMPVETKKTLRWAREVVKRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDZ4</accession>
    <name>A0A2R6NDZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001347">
        <property type="protein sequence ID" value="PSR70597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDZ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NDZ4"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="344" mass="35912" checksum="83DA1782C40F0D2A" modified="2018-06-20" version="1">MDTGSSSGEIIGHSKTIKTHTKYVQDVKYAPSGDHFASVGSDAKVFLYDGKTGDTLGDVESKKAVTTWTLGSGVNNQQVGNVWTEGDDIVSLSMSGDLNIFDKRTGDKPARVLQGPSKPITAAVQASSSGTFIEGVADGRVLAHSGSEYSYLDGPGHTNLVSGIAVASDGKVFSAGYDDTVREITPDVSGFIIPPHSQSSFSTASQPKSLAVAGDSTVFVTEVNAVEAIRSNQKVYDFQPKFTPSAVAASGSVVAVGGEMVNSRWSNHSGRVLSLAWSADGKHCASGSLDTHVYVWSIAKPMKNIAIKNAAAGSVNAVFWLGETKLGSAGADGCVRTWDITFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEB3</accession>
    <name>A0A2R6NEB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001334">
        <property type="protein sequence ID" value="PSR70714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEB3"/>
    <dbReference type="STRING" id="98765.A0A2R6NEB3"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11359" checksum="24617CC2E46F632B" modified="2018-06-20" version="1">MEGIGGKHGWSWIFILEGLFTVLFGVCCFFIMPATPFQAKFLTTQEKQYIDSVLREDGVVAQSDEDDAFDWSQVRKAFASPHVILMAISAFFSGKCKDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEH8</accession>
    <name>A0A2R6NEH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001323">
        <property type="protein sequence ID" value="PSR70784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEH8"/>
    <dbReference type="STRING" id="98765.A0A2R6NEH8"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="316"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="378" mass="41162" checksum="A415418605D2B384" modified="2018-06-20" version="1">MSAVQAWTTSGFPANQVASNGRISFRYFRPACAETDSEPMGKSGRTPRRDLSVVVPTLKQVRSQPQIRGENKEKGSPQPKKPSMKKSLEHTESVDVRDCDSPEKSPPKRGRPASCALKTTRASSSSLDQSPSPARPAPSKKPRHVEAATSKAGPSKVNETPSMIARTQRSAATKATNKLCIEIMPDVMNFQKELKSGNVKCAYDMEQASAKAKGKRKEKGGTAVAVPAQRKKRISMGDGEPELSAWEPEKKKRKTGKGNGRKSDAIELSVDENVAVEVAKGRRKSDIKTSATADRPASHTDVKNIVVMTTQVALLEDVVKAFTKMGAKFTQKPSECTHLVARSLVRTEKFLCATTTAPYVVTVAWVETCVSNKRIMHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NER3</accession>
    <name>A0A2R6NER3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v13561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NER3"/>
    <dbReference type="STRING" id="98765.A0A2R6NER3"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR70522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="21315" checksum="CF096AE8BCFE6EA8" modified="2018-06-20" version="1">MSNDGPNPTPEDKLKYDAAKKELMQALAKKRSADKQLQTIEVQVYNIEGTYLTETAAHSGGNIIQGFENYLKNATGSRRKYEVTEADRIFSTSSKTYQKALELQGEGDESTATIEDHQSRMSTPGLTTVVLPAAKTQEMTAAQQKKHRDREYQRKKRANAARRSAALSDEESVTSASGRRPTKRARLGDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF01</accession>
    <name>A0A2R6NF01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001300">
        <property type="protein sequence ID" value="PSR70943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF01"/>
    <dbReference type="STRING" id="98765.A0A2R6NF01"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="19374" checksum="F4AAF62360575738" modified="2018-06-20" version="1">MEAYGGDCIFGVIYCGGPVLTRSLHSEYIHPHLLSVMHDWFSTDGDTASHAAETYLESIVEDMDKTLSYDEQLQWMGSFAIQSPTVRIHTLTRTQTSAVWEREIRKKPVMIVQGTHDRHARAEGLLEVAKKWIGGEFETRLVDGVGHAPHVERAHEVSGYVAAFMHKINLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFP4</accession>
    <name>A0A2R6NFP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFP4"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10993" checksum="4C9F8B1A889BC346" modified="2018-06-20" version="1">MSDTEHITYSVESNAVYAIVAIAGEWYHNHYVLALRIYLLALTLYDHILTLPQEIDHIWRRKVTGVTVLFVANRYITLCMIFLVFQSTWSDSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGB6</accession>
    <name>A0A2R6NGB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGB6"/>
    <dbReference type="OrthoDB" id="2790797at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="12257" checksum="7C7CA0BAAC6B6931" modified="2018-06-20" version="1">MAVFLQLPKPLGFQFGQFATAGAYGTPIVAVLIGETVGRYLNDWIMNVCIRRNKGVFEAESRLWTCYIAVLLYICGFVVIGAGFQDQLSVGSVIMGWGIAEVATMVNTVAVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGG9</accession>
    <name>A0A2R6NGG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mo25-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001282">
        <property type="protein sequence ID" value="PSR71484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGG9"/>
    <dbReference type="STRING" id="98765.A0A2R6NGG9"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="33350" checksum="DCE3F4EEF12703D1" modified="2018-06-20" version="1">MNFFKTKPRTPPDIVRSVRDTLPKLESAPPGDMRKRAGEEVSKNLQQIKAVLLGDGDPLPELVAQLAQEMYSTDLLYHLLLHINRLEFEARKDLVQIFNNLLRRQIGSRFPTVEYLCNKPDILFAAFKGYENEDVALNTGMILREMLRHEPLTKILLHSEQFYNFPHYIETTTFGISCDAYTNLKETLTRHKPMVADYLDKNYDRFFASFTTLIRSDNYVTKRQSLKLLGEILLDRANFNVMTRYIANEANLKMMMNLLRDKSKNIQFEAFHVFKVSLFPRQFSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH71</accession>
    <name>A0A2R6NH71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH71"/>
    <dbReference type="STRING" id="98765.A0A2R6NH71"/>
    <dbReference type="OrthoDB" id="2593747at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1252" mass="133030" checksum="18B6963806BC8FD4" modified="2018-06-20" version="1">MSTYNSPYGSGFPTPSSFSSVSEAAAPSTEKIRRHPKYYLNGGDVHFLVEGYLFRVHRYFFERESAVFREKLGATPASGQAKGSSDAHPFPLDNVRELDFSRFLWVFYNPKYSIYDANVEEWTSILRLAYDWRFAEVKRLACRYLEKFEMDPVDKIELYQMYEVDKRLLIPSYISLVNRLEPLNIHEGRRLSLETALLLATARECARGKPLDSGRHSPTIASVAVDAMVSIIREVFGLTNSSPSSPSLEPISEGTGPSAFTATLMTPMKIVTSPPVQPPGSPTPISKTHSSTATSPGPISRGASSVPAVPSYLAFSDMASPSNTVTSPTKTHKPTKTSDVFGEVETPATATTPSSEKPPKTGQSVPSAKNLPRQMPQLALAVPPAQTEIKKMPKPWPSPNPQTPLTPSKKKMTQLDLQPQQTIRPTRELQRMETKGETREVARGAIKGATGMGTRAETRMGRTKRTEHDIDTSSDSSPQTFHTDDVTTTASGAGAIDDEYDHALDDNVRVEGSETTEHQHSPSVETLANAAALADENVEPVAERDESVVLTQSASSDLHGEMKSSAEPESTIVHHTPPPSESTIASDHRPASATTSEDLSAHLTNEASQINEAGEEVSDAFGNNKYDEGSAQTSELDSVSEDRPEAVGSDDLPAKDVADDRLDVTAEPTDDDAWDFDDDSEEAAASSDLLQSAVLIQFDDAQEQGSGVLPTPSGDDELEAQLTTTEDQGRPDIVKSQNPGVSSPGAAAIEAESILSPMAASGPTSETALSETERDTETEGHFSVGTEQSDVQVDAQDPEVDATLERSPPVTAADDLDEAETTAGASLLDSAILVRLEDATEGGNTELSPASEAQFPVSRIGQSPSLGPRENDTGKPSLTAESTQSPESAVDETTAPSHAERGSAEEEGVEANAKDQGIESTPDSDESKRGLEGAAWNSEVAEAKLETHADSASGQSVDSDDNSSPPEQVTSITSPVSVQTVEETVKGVNPDQQEKLGAGEHTGTSQRQDEGVLPGEDTGALLGGTEEGESSTGVSGATVIGEGAEHEALPHATPREGQSISSPTGEEESVPEAKDGAAHTPGHEGISMDANVPIGVDQIMPEPEPELEESAISSSIENDKQAGDGKAIPASTGVDKPLPEIIEDGVIVVSAQDNQPAEGDINMQEQENTSLTKPELRVNTELGQSMGDGADNEEPLAGLSMAEKLRQDLEDQDTDSAQTTETDTPGDSAASSPAKTRVRRKGKKAKRGTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHE3</accession>
    <name>A0A2R6NHE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001245">
        <property type="protein sequence ID" value="PSR71743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHE3"/>
    <dbReference type="STRING" id="98765.A0A2R6NHE3"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8415" checksum="DB258AD247B57054" modified="2018-06-20" version="1">MHALELSKTAWNASITRNDDVEASHPPPAVTKLLEDRARHYLTLAAEVMQCFGPEGDEGGPLEEIRIMRELLQGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHK2</accession>
    <name>A0A2R6NHK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHK2"/>
    <dbReference type="STRING" id="98765.A0A2R6NHK2"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="198" mass="22247" checksum="9B04048D478CD350" modified="2018-06-20" version="1">MTIRTSNPGLLTQDLLYADNPCAACSSVLPPSPREFPIRGLNLIRLLTQNRIAEFHTTLESLPLPADSLASNPFISHPINLERWLMEGSYSKVWNAREEAPAEEYKFFVDSLMGTIRNEIASCEEVAYNTLPLKDAATLLFFKSQSELIPYAQQRGWQVDLTGESISFAKKGEEKIEVPKEKLIAANLAYARELEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHV9</accession>
    <name>A0A2R6NHV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHV9"/>
    <dbReference type="STRING" id="98765.A0A2R6NHV9"/>
    <dbReference type="OrthoDB" id="3352270at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="567" mass="64675" checksum="DD87B2F26C7D6B4C" modified="2018-06-20" version="1">MSPIHSLPVELLSRVFVLGLPDDEYPRFPPLGVPDFGVLVSHICQQWREIALHTPMLWTTVHFRTVPHMDRAKHYLQRGHRHLIDILVDTCALEEHTPGYTIFREEFMPVFYMLIPHIKRWRSLSLKVRDLKCKIGARTALSTCGPAPALEYLKLWHVEHWDSPERLYTQIGPPPVVVFDKSLPSLKHINLIGVNLPWKHSPFLEDVSSINLGLHSDNVRIPYDLWAHMLSTSPDLEKLSLHYSGPRMEGPDWPADVITLPNLHEITLKDLDLTYLMELFRRLSMPLVSRLQLQLSGSDFAPFLQYLADPPAPPKDVKDKTQAKETARGSVFPVLDTLVIKALECSAESFQKFLQCCKTVKKLEIGKAKIGDGLLEELMPKQHDELHVAQDKDKQWAPLHDARKLTGVTSLVPSGSGSRESSTDSDLSSSSVSLSTAKTTPSSEYSSLSSRPYPDIPLPELHTVRWSRFPSESLRSYIQFRRARGRPVKCWVVHERLRDAEMETMADEMRKLGGDEKIVWFSRNEEEEEEEEEEAEDEGSEYDEEESYSEDEVEDADEDGDDAADDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI25</accession>
    <name>A0A2R6NI25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001224">
        <property type="protein sequence ID" value="PSR72034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI25"/>
    <dbReference type="OrthoDB" id="2802435at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="223" mass="24699" checksum="34A9EF24F71F04B4" modified="2018-06-20" version="1">MSRSPNTLGSKPFPTMPAKMASKKKAKDTDKTETEKEALAVVSTEPASLSVLKAVREFEHDRHLTRRAAERKEHQARKGLMNGVITWSAYKYSRTQAAEAAQRMRGLHGKGGWHIKLVDDVDVADVIESDWVATVESRPEVTEVPLAELVKPGKARKARRRGISGDFEFIPNNLSVIVLEDSAAPEPEADDPWECVDWDEDDPDGDHTARRAPSYAEVVATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI63</accession>
    <name>A0A2R6NI63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001223">
        <property type="protein sequence ID" value="PSR72049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI63"/>
    <dbReference type="STRING" id="98765.A0A2R6NI63"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="99"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="399" mass="45054" checksum="F871BF8FF0283F12" modified="2018-06-20" version="1">MSDHPVPGSVCDTRGSTSVTELESALQTLSVTGDDDTTRILSEHPRIVLADSRLKGSPCFLYLPPGKNEFVLVDYLKSLRTVASWPVWNQPAPSPPSDPESCSYRIDMAFDKGLGMYATRALKAGELIVEERPVYAMRRQIIRGEDQTHENGIFHRNAVRGLCPKSRAALMSLKNSYPPDVHVVPGTLCTNYLQLDITPEPDVMNEFVGCFPVLSRANHACSPNANYYFSFPSFTGQFWAMRDIAKDEEITIGYCRLIAPRRQRQADLRDRFFFTCTCSTCLLSGEQLAQSDERRTKLEKLLTTLETNSMPKFSSPTGALQLLEKALGWAQQEKLAVHQAQILFYGSNALTVQGTSPDVVLDWMKRARELFKDTEGERSYNVRRLDDSIQFAERMLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIJ2</accession>
    <name>A0A2R6NIJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v12293</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIJ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NIJ2"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="286"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="571"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR71792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="674" mass="74674" checksum="20594CD96738733A" modified="2018-06-20" version="1">MKWQALDQIFVCDCLRISQNGSGGLRTSIHYMSAQALLLTVIAAMSRNIFDPSALVATLPNILPPSKKSLQSPQDAIAALVHSALTIIGFRLLGVDESSPARTFVQNQLPEEWNVHGPGSYVFRYKHEQSSLEFLVKVSKLGSRTVIYAIALEVRKLLSVKGRLFKVHIQTDKTASLDIRTDDFVSPAFFPHEITSTSEPVVHGFISSNRITDFMSQFQLMIIQKLMPGLQKEGYVEQAADSSTTTGQGPSQPRNPPPVRPEPATPPYGPDRFSPLQVPPRNPLEIGRSDLEPFPRNPFAPPSLFPGSEGDGMFMGPNHPIFGPGLGGRGGRGPWGGDGYLPPMGAPPGARFDPVGPFPRNGRGMPGAGNTRDPDFDDFPPPGSRDTALAAGLLSMPQVSPTRNHLRMSPTSTSPTRKPIPHGFLPSYKPKQRPIQELSIRELQDTYERNARILSQPAPSTSTYVQRISAEQAQIEERLAELGVDVIQKMMHRTTIKDEAEDMNVDSEPQQVQQPQPSAGPRPISAKQRALQKFSAQIPHPDSKSNIFTYQEAMQIEREAHELDLQRQKELADKQEDKRRRMGLPAQGEKALSKAEQEARMWAFMNYKPSGSDLEDDDDDDSDDDPANWFEDDQDDGRKGQDIIEPDVEDLSSIIRIDDSRIPQSIFYEPPDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIY5</accession>
    <name>A0A2R6NIY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIY5"/>
    <dbReference type="STRING" id="98765.A0A2R6NIY5"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15003" checksum="1AB1FBAE335E4F56" modified="2018-06-20" version="1">MLPLEQRPGVISLLAGKPHSSTFPITSLNFTVRDPADPNSELPVQLSQEELELGLQYGPTVGIPALVDWFYGLQDVAHGRKVGEGWNISVGNGSQDLIYKVSRGDMPRKFIRLIFPCQAVTALVNPGDAVFVEAPVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJP9</accession>
    <name>A0A2R6NJP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001152">
        <property type="protein sequence ID" value="PSR72599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJP9"/>
    <dbReference type="STRING" id="98765.A0A2R6NJP9"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="190" mass="20519" checksum="80CDB9C7A34E0A6F" modified="2018-06-20" version="1">MAPANQKVPAKKRIRKRKRRVASSSESDSDTDTSSSSSSAPAVVKAKAPPRPVEPESSSSEESSSDSSSDSDSEPAQAISHPQKGRDTQARARSPSLPPIPAPIPSFLSETEPEPEIVLKEKFRKFWMSSVADAFKTDLEEIRKEPNMSTSRLAVLIDSLASGAEVYSSSSRSDPTQDLNEMEVVLGQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK05</accession>
    <name>A0A2R6NK05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001143">
        <property type="protein sequence ID" value="PSR72666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK05"/>
    <dbReference type="STRING" id="98765.A0A2R6NK05"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="317"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="43874" checksum="D6D3D0E68A693127" modified="2018-06-20" version="1">MSTPQKGDLDLDAKQKLEFWRRDVLQRNNPSSMLPSSAILDDTTIHLIACTGRISSEKFSQFMKHQWIWWDIYGEELAAYRESLFQHMKPLPEKAQKTKKLQKPKVVSHSVDEGSSVGGAGPSTGLLHFESLKVREFRAESMTVNMFANTIRRQLTTNTRPRLQTSCCRAVSTSTPKASTSLRYLRQISLVTSIAFTAYTAGSLYPPTFATYVSPRIAPPPPDPNHPSAIAYTEALEESLQNLPYLKELRNSPDAYEWYETRPFIAVPKEQLANSLTAGALRGPGKLTLPPLVRARRDESEAVILIHVGTGLCGHEGIIHGGLLATLLDESLGRLSLLNLPDKIGVTANLSLNYRAPTRADQFIVIKTRLIEAKGRKVKVAGTIEDLEGNILVEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK40</accession>
    <name>A0A2R6NK40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK40"/>
    <dbReference type="STRING" id="98765.A0A2R6NK40"/>
    <dbReference type="OrthoDB" id="2576580at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015310921" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="173" mass="18242" checksum="AD8BD92A73E9F7CE" modified="2018-06-20" version="1">MVSRRFAVSAFLGVLFSSAVADLQVLAPGGPNLWWGGYQGTSIKFGFIGDLQTSGPIVAQSANTIVWTCADSPFQSFTILIANSAISPVPEAIIASENNFDCSQTTTAAQQLNFPVGTGYTIQFANPLNNTDVYAESQQFEIKPLGSPFPPASATPVAAKRTFSERASLATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK73</accession>
    <name>A0A2R6NK73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Importin subunit beta-1/Transportin-1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v11396</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK73"/>
    <dbReference type="STRING" id="98765.A0A2R6NK73"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="10">
        <location>
            <begin position="515"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR72701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="920" mass="102914" checksum="8A336EE2C5D3CCFE" modified="2018-06-20" version="1">MTSWTPQPTGLKQILDTIIESTNEENNQDTQQAITEKLNEFTRVPEYIAYLAYILAFMPQQEDRIRTIAGYLLKNNARLIVRAAPEVVAYVKASVLQAFFDPSMMVRNAAGQDIVSFLGILEPKNWPECLQQLVHTLDSSSLDQQEAAFNVLEKACEDYPRKLDVEINGQWPLEFMIPKFLVLSEHPSPKMRAHAIACLSYFVPIGCQALFTHIDQFIACLFKRASDDDPQVRRHVCQALVLLLASRPEKLMPEMANVAEYMLYSTKDKNENVALEACEFWLTFAEDPDLAPWLHPLLGKVAPVLLDCMVYGEDDLLWLEGDAEDAHVPDKDSDIKPRHYGGKAHGLEREAANGDGSSKPKVGAYGEEFEDESDSDFEDEDDEFADEMSTEWNLRKCAAAALDVLAVRFGADMLNHLLEPLKTKLWSEDWLQRESGILALGAMAEGCIDAIEPHLPTLIPYLINTLNDSKPLVRSISCWTLGRYASWCTQPISEEHKNQFFIPTLEGLLRMVLDSNKRVQEAGCSAFATLEEDAGPELAPYLEPVLRNLVIAFERYQHKNMLILYDAVGTLADAVGNALQNPSYVDILMPPLLKRWSKLKDDDEDLVPLLECLSSVTIAMGPAFLPYAGPIFERCSSIVHTSLLQYQAYQQNPDMDEPDRSFLVVALDLLSGLTQGLGMALENSISRSQPNLLSLLTICLKHPQAPVRQSAYALVGDLAMNCFPLLKPHMPAVMAELIVQLDPEPKVEFISACNNAAWSVGEVALRYGRDEPEFQQWVHLLVSRLIPILLHPKAPRSLHENAAVSIGRIGLMHPQMVAPLLPEFAQAWCQALYEIRDNEEKDSAFRGLCTLVQTNPAGIAKSLLWFCNAIVKWNQPSAELNAMFQQLLQGFKQHDAAGWAAQVSTFPPAIQDKLAVRYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKE5</accession>
    <name>A0A2R6NKE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKE5"/>
    <dbReference type="STRING" id="98765.A0A2R6NKE5"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="816" mass="89838" checksum="2D88DC33544F064B" modified="2018-06-20" version="1">MADPPVSSNPTSPISALLQKLGMTREDLMLHTEQMRAHLSQPEEPPSDVPPAPKTRSAGMSRTRSISNVGAQALSPPPPRTPVKSEPLDVAIPTRPMDTMERVIERKSRQGRRERKDSVTLLRDNRRVQAVQNNTPSRCETPQLAPETPHHYKYYSERVIGEASSSQCTLDSFDVNAFPETPSRKEPKSANGFKVPGSRTRLPKTPVNRHLYSHASSSCASTPCSSPSRIVNIVSSPGPMRASLSSEDEDGLEDLPYTLPPGPYSREKPDFSYAALIGQAILSSPEHRLTLQDIYEWITTVYPYYTRGEQTWMNSIRHSLSTMAVFRKVTRGRNEGKSLWAIWDSDIPCFANGGFRKSLCADMVKSKPPPAKSGPKRKVMEETLTKETKRRKKNVLKDEADGSTIPLPSMFTAPILPPFYTPVYPNAQHQPYYQTYVPQPLPAEVIFPPLPAHSAYHRALTMSSQVSRQTSAESISQAHSTAESSSYSRAIPPKAPLSSSSSIPDLTPNCSSSSSPPLSSQPSLSSVEVNQDNETIPKILDTEDEVDRLTAQWLASPSTLDALEVGITLSASVAFEKNTTLGALRTTGRKQQNRKITLVVPPSPTLERQFVKSKVCKKSSSPQLLYPGNSRPSTPPPRPCTPPRKQPSLQISAQRTPISHRGLHMSPSPSLAHYKSNLDPPPAAVFHPQAPLLSGLVPPDDPSLTLPNPEVLRTPSRKRASPGDGSGSRGRFNRSPFPPVTPKRLLFGTHAQESPFRTPSIFDPHDPSALIDEEVLRLGSQNPLQLPDSPMGFFGRRSILYESPGLPSPERLNRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKN3</accession>
    <name>A0A2R6NKN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKN3"/>
    <dbReference type="STRING" id="98765.A0A2R6NKN3"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="418" mass="46106" checksum="0A1ABDAB2006393C" modified="2018-06-20" version="1">MDGSALGWGTDVGGSLRIPASYCGIYSFKPGNGRVGTMGAVGMLFLVFKNLDERLILGIDCIPGFEAVRTVCGPMGRSVEDLELACRVVFGLSSQNYGPAPLPFRAHELPERLKFGYYTSEDVLLIIAIWIPDNFIKPSPVCQRAVLQTVEALRREGHECIEFTVPEPSKPMELFLALISSDGNKTLFAPIGPDPQVRPLLDAIGLTNKPLQQAELATVALGPKLYGWLRSFAAWFIERSFDDRICANLLRASRKKSVDDFWRICSEAKEYARMFNQEVWEKHQFDGIIAPVQAMPALPHESVAYVGSLSCPTVLYNIVDSPVGTIPVTRVDPVLDSLTEEWSNPKVGTGHGSPLVERLLYRGEGAMYNAQKMAGLPVGVQVVGKKWEEEKVIEMMKVVDRVLGQRGFGPGCWSSQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL65</accession>
    <name>A0A2R6NL65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v11041</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001107">
        <property type="protein sequence ID" value="PSR73094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL65"/>
    <dbReference type="STRING" id="98765.A0A2R6NL65"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="909"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="239"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="785"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR73094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="947" mass="101412" checksum="4D63EF9B0FF55735" modified="2018-06-20" version="1">MSDLFQLIEDRREDHDVDVIVTFLEIYNEEIRDLLSEPGTPTPRGGLQIREDKSVKVVGLAELRPKNADEVKEIVLLGNSRRTQSPTHANETSSRSHAVLQVHITQSPRTASVTEQRTMATLSIIDLAGSERAAATSNMGQRMVEGANINKSLLALGNCINALCESGGAVRHIPYRNSKLTRLLKFSLGGNCKTVMIVCIAPTSAHFDDTQNTLLYAERATRIKTKVVTRNVLNVDRHVGQYVEAINRLNMQVEDLKAKLAGKRDAEAEKEKRKKVEATAEVQRAKKDMQVKADQTQASLVDGATCSGKLSFAQSKLKVIQGRLTELDVQASTSPLSADLETERGLLRSLASSEEQALKPNSALNTRIQRSNNSGAMFEATLRAVSERRSDKLDELSVDNVKLDARWRKAEMERMKAEASRSALQEAVESQAGTVVSLLGLVGRCTVMLNEASRALATAATDGNDGMEETAKMLAASLKNVADGNDSAFKALLGHTTAEYTIGPAPPSSSALSSFKGYPSTLGLGRAAATAGPTTSQQSQARIARRSSSYGSSMGSSPLRKTYRSPRKSLRSSMAGSVPYNRRVSDKGKKKGVQWRDEVGQGEIDDGGLRLGSAPAIAIIAPNTTIDTSVVTPTQLNISESISPSSSDPFIEPSTSIPSLSTPATGSGSGSGSSLHRSTPTLGPESDWEDEKTEESFSLSFASGLSSSSSSSRARDHLRPLSASTSAAEPRSGAGRRPRASRLDPSFLKSRTRGSTLGSLAETEEERASPRRPSPLSDRNMNRVPSPTASSDGSSSGSGPGKLYIPKGRDRHTSSPAKRVPMTPKIVGSSKSNRRRSNIGPMRIERPRRRSSMIPQLSPKFKSEGGLGGVGDTSVSGARRVAMAERSPAKRAKRASLLAVPTTTVTITTMASRPPSSLKLKQSPVDPNASLSDISFRAGGGSRPTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL85</accession>
    <name>A0A2R6NL85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001111">
        <property type="protein sequence ID" value="PSR73086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL85"/>
    <dbReference type="OrthoDB" id="3233731at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="481" mass="52546" checksum="DFD2074F87354116" modified="2018-06-20" version="1">MQTRSENLQPNYAFLSQPPSSKKRSPPNMGASEGPSQALAENVRRRSSTVASVSAWASTVQPGAPAPSSPSRHGSVADTSRPSDSRSRRQSIKPSPPTPTYIPDSPTSSHDTITPTLKTDHKHDLPSVGYTSIFVTLPKTPPVEYTPDRRRSMSRPPAPAVPPSPAPTTSQPRGLSRLLRPKGHSRSKSAVEVPPPPAASSSKSKTKPPPTHTSITREKKSKYAEMRPPQVATELALAQFTGGGTMEHHMNRYAERQAKNSGAATMMNGQLVGVSGLYQDGEGGVWRDQEEEWEYTHLLAGGNSQDASGPDWVQFDEERGVDASDDRRGSVSTQDSDLDPRYTMRASEPCENEMDVSHSRSTAKHLRKTPEFNLDIFPADHTTHHARSRPADRQRRRPEPLDLAPRSSNFSPSRDRQVDPAEIRRDFLESSFSPPPPAQYVKNASSATLDTFSTKRSALKPAMLNVKGLFKAVGGKKSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLA5</accession>
    <name>A0A2R6NLA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001107">
        <property type="protein sequence ID" value="PSR73091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLA5"/>
    <dbReference type="STRING" id="98765.A0A2R6NLA5"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6132" checksum="96649DFB26BE5214" modified="2018-06-20" version="1">MSADTISVLAPADFHVHLRQGTFAELVTKHVRKGGFTLAYVMVRRTSQSKTNNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLA6</accession>
    <name>A0A2R6NLA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLA6"/>
    <dbReference type="STRING" id="98765.A0A2R6NLA6"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="483" mass="53708" checksum="75CB73269340727D" modified="2018-06-20" version="1">MTEDAPSDTAQSKLDTDRARRAATRGREKLREVHAIFASIRDEVRGDRFWRYQRNVSPGLQEYIEALSFAHYLETGKLVSYDEVQKSLSDEEGVPFFPLPLEDYLLGLSDLTGELMRYAISSISRRGGRTKASEVCTFVRGCKGDFEALTPYFRELRKKQVVTSQSLEKIEDEIAAYAIAVRCSEYDLPPELMDDIVARTVSTSVGSGGAESNSRKKGRNDGFEDEYDARARPPPFHHPPGLPAGLISDYRSSASLILGYIIKAIANRESKGIRLRQSPNSSPTSSPPSRNIAMTLTFEPALGVRTTLPVPRDGYASFSFKASFSSREAYEQARDEGVRVEMWTNLPVGTNEDEWHALAFQYTADNKSHVKNASASTLNAEAHDQTDASVYLNVPLSDIRVGSTFSFTYRLVHPSGAIQWLGAYGQNGELSIEDFDPRFTLADGWKFGEGDRVEGKPLESAETEVAILNNEMEWTSWAFGKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLG2</accession>
    <name>A0A2R6NLG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sphingosine-1-phosphate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLG2"/>
    <dbReference type="STRING" id="98765.A0A2R6NLG2"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29434" checksum="643162353EA40026" modified="2018-06-20" version="1">MIVGSAINFPDGNQDDIIALGKLAKRNKIGLHVDCCLGSFIVPFLEKAGYPTDLFDFRVEGVTAISCDTHKLTGPYLYHAHSTHTYQGNSVIMYRNAELRTYQYYVNPTWTGGVYASPSIAGSRSVSFKSGDQLIYSCAIYFGDHSPGSLIAGTWAAMQYMGSEYVIYRFCFTQRTVSYIYSVHSGYLESCKSIVGATRAIAKTITTDIPELYVLGNPPASVVAFASKHPQVNIREVGDVMSKKGWHLNAIVQPAAVHIAVTVSNTPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NME0</accession>
    <name>A0A2R6NME0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NME0"/>
    <dbReference type="STRING" id="98765.A0A2R6NME0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33266" checksum="C46B9AC5C3E35B4B" modified="2018-06-20" version="1">MSSILPDTLNPATLLSRRFRPDQIPDLSSRVAIVTGGSAGIGYYDALALARAGATVIILSANEDKGKQAEAEINKQLKEITSYGSVTWHGVNLGNLREVDAIAKKLHSELDRLDIFIANAGIGQAPYGLTEDGLERHFEVNNLSHYVLILRLLPLMKKTAKKLPPCTVRIVMQSSEMHRVASGSTKFFSKEEINKDDDGSRLYGRTKLGNILFARELANRKLTDTEKPILAISVHPGTVDTDVQSAWTESYGALGKIMEKGTKIFGKSAPEGAEASLWAATSTDIFEGNWRDFQARLDYCTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMQ5</accession>
    <name>A0A2R6NMQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMQ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="9635" checksum="3B34005B5B5F8B65" modified="2018-06-20" version="1">MADPGKCVECVGPECQVSSTDVLPSEEREEPTLKAEDPLDSTTFAAPSALPLPSIAIEFCDRVCLLSQATGIPVLILSGVLCSVAGEQNPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN02</accession>
    <name>A0A2R6NN02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN02"/>
    <dbReference type="STRING" id="98765.A0A2R6NN02"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="93"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="205" mass="23146" checksum="A2177A5210D7A36B" modified="2018-06-20" version="1">MVPAPIPTFRSLQGYNPVDETAHIGTSFPSDSTQLSALLDAENSDELIRDLATLVSHRGVVFFKNQDITIQKQKELGLRLGQLTGRPAESGLHKHPVSEETPELGADTSVISSMGFTKRILELYPEESDNLLDYLYRQISENHDLQVRYKWGQNDVAIWDNRVTFHTATNDYVDNRQGNRVVGIGEKPFFDPNSKSRRAELKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN33</accession>
    <name>A0A2R6NN33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN33"/>
    <dbReference type="STRING" id="98765.A0A2R6NN33"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="141" mass="16088" checksum="8FB79986AFF7CDD3" modified="2018-06-20" version="1">MSAMAEVIDESIRNMTSNMVTKADQEKQVDFAQLKSELQLTEKNDLAMLKAENDRLVTDIEKLKQRLREEITRTQAGVRLDLNLEKGRMREQSSGQELKIKEVDTRIEQEIAALRTQIQSSKATTLQYLVGFVLDYGLQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP11</accession>
    <name>A0A2R6NP11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001014">
        <property type="protein sequence ID" value="PSR74189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP11"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32388" checksum="9E5F9B10023A85B5" modified="2018-06-20" version="1">MSSTPINLSDSPSSLHAPTLRRSLRKPKVVETPTTKDLPSEGEASTSSPVGNSRKRKAASGSKTSKKPRTYAPPETYAHLDPLTDILQPGLDRLTNRRLSPSEDSMLPELYNYGMAAELSSGEMVSGVPDLLAKVALYRPRIVCFVGKTIWEIFCKAGCKLAAQVTIAKDSDITVMRAATTTVKVAKSTTSLLSHKPTFKWDGWNIQPYKVLHSQTGEPVVDSLSRFFEVSFRLSDQQASVEETLFFVVPSTSGLVRGYQLPDKIKIFTHLQEELASLKSGALDTSRMTVFPIPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP86</accession>
    <name>A0A2R6NP86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001007">
        <property type="protein sequence ID" value="PSR74281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP86"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="14301" checksum="C5929320AEA99BD3" modified="2018-06-20" version="1">MNELVRHAGDKIDWDARGNQGKTALDYAPESRLPMNLLRLLKRYSRRDILEQGRGMETMGMNIYIVAVAGGGHGSCANARFAWWKGLGFGRWTQRKRRMRMSFQYLGPLNHEGDLVKRLTRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP96</accession>
    <name>A0A2R6NP96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001007">
        <property type="protein sequence ID" value="PSR74275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP96"/>
    <dbReference type="STRING" id="98765.A0A2R6NP96"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="309"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="893"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1017" mass="105653" checksum="1944602D95279197" modified="2018-06-20" version="1" fragment="single">MPYATPADPSSSTTTIPQRAGHRRTRSSFTDEHGPGAFVSLGTLPRRRASNSASSTKKPLFHITVDDDSPPEQEQDDHSSSSTPSNSPQPSNSALSIDTSLKGLGVSFGNGGLLTPTNSLRLSMENGRFSPSIIPPSHIDLSNAKSSSVQGVPFPKSSPLSPNGLRAPPSPPRTSSLPRTPSTSIILSNGKPLKPSLKSSTSSPNVSEEFAGRLTKHMRVQSAPSTPRVHFADKDAGLETVRLFNRSGKPASLSKPPGDETETETEAESYPFPLFSSAPSSSSYSSSNSSQLIHEIDATPGATSPIPSHNPSAYANVHVETVTLPRTRPPTLRGTVLVRNLAFEKRVAVRFTLDDWQTTSEVTCKHVVCLPGLPPPFPGSRLVGDMVAGIAAGDKDDEGGSSTWDRFSFTIRLEDYESKLAERTLFLVARYLPVNGVDGEFWDNNNGSNYRIGFRRSAPSPLSTPLRQPFATVSGALADMLSDGGSPTAQQRTFSAPSSMRFTPTTGTVPAVVSRVAAVGEGNNGPRGHGHGHAKVVVPVAIRMPGGSALDTSSSPDIGSSGVANVEGGEEVEKTSVRLDVDAFRGAIPLARRHSSPHASMDMPHFPSPPRSQSPNDAPPPESSSAAKMSPTAAYISRRLSLSNYVAPGTRAPPPPTPPAVATGIATPPSTPPQNGDVPLPDVSDEGKDRHAPTMESSSPPLLSPLVLVGGMPATILDSLIIDPTGNHNNQQHPMSFPFFSSSSSSNSSTPNANSTSFLQPPQLMSRSASLESDDGNAPFSPTSRKAQPFGMQSLGAQLRLGTGAGRSNSGGIVHQLASPPVSRQGSEDGSGHSSPFNGNSGRNTPKERSSSPPPPTPPRRGSPSRLENPALAAVALADDHLDVRTRRSSSPAVDAQALVQGQAGQGKVDTSDSSYAAFVRQWCFAQSTPPTPGVVSGSPSSSSGSPNPIIPGPPTLAASGGASMSVGAASRRQPAWPAEHQVGAGSSMGIGSGYGFPGFGFAGGVHPMAEGMVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPJ5</accession>
    <name>A0A2R6NPJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPJ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NPJ5"/>
    <dbReference type="OrthoDB" id="3223195at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="486" mass="51566" checksum="1344802570D5C1CC" modified="2018-06-20" version="1">MLHQEVIQPEVLISLLNAMTFCIASIVGGVFYVSILALADCLILPLNDHNQLLSNPENTDVNGETIGLSAYLYEATNDDKYATAAELAAQFIQLHLYNGTIILDTFTVANCFVNADLAVTYNSGFVIEGLSVLASKNSTWSPFLLNLISSTVPFSAWTNASDGVIIEGSQSDATTNGFGVALKSIFVRGLYEAWSRAIPNSPAALLIQSYLTVQFNALTTLASIAGSNVYSSEWEGPPVQNSVPWGQLAALDVLNSAVGIAPKPATDNSTSAIPGPSHTSTTSSSGAPTPTNTFAADESNSKHAPRTPIVVGIVIGCVVLVAIVLLVVFIIRRRRKQGQEDYVRAQMEETAVPFNVNPYRPEMSQTTGTIQSSSYAYQSSSESRATFSPTSDSKSRSDLPSIYSGSGSNPSHANAVAGPSNAVHDTNGAASDSQLSPIPLRADTRSNGDSETDLAAVPRLIDQLNQILSRLPQGGVDEEQPPQYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ22</accession>
    <name>A0A2R6NQ22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ22"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="205" mass="22556" checksum="8C72E915808F3F68" modified="2018-06-20" version="1">MFNHPQRGMRSFEDPYTPPVHVDLHPSMSAGGLSSPSQAYYTQGMNQDLFSPTTPPHWPNSPYIPYDVSTKPSTHHTYSAESRRVQSETNWHPRSISGSGDLSSDEVRHRRQAGGDGWPSGRVVEGPPLASMPLAHSSEGTTTTLPTVRTCEPVRTGSGSSTWSWDDNAHHHQLSSASSGEHPHRTATRISNAADYASRYSTQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ38</accession>
    <name>A0A2R6NQ38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000974">
        <property type="protein sequence ID" value="PSR74641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ38"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ38"/>
    <dbReference type="OrthoDB" id="2803928at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="460" mass="50736" checksum="A8B1A88C278358A7" modified="2018-06-20" version="1">MPASSSRLPARPARPTPMASTRIQQPPTPPRSSPAAPEINDEEGVDDVEEVADNPKKRRFDELCEALDSNPKKAKLVDEYKQLTHEARWVPLSISPFLDTEFTIRNGAPLPEDPSVPVLDLEEISEMSPKEIKELRYCYNALKKTITTIRENEGLWEGNSLAALIGTIDSYIGRARSDDLGQLKKEVLGLIPKREGVEPLAFNNPNKSARGWAHVSTGRLLCPCNRLEEFDANPKRFCRDVENGVIQINAEDFPCFLYPQDSYNPDNVEEGLLRGEFLRSVFRSIYTGPRTATKEAPGPSAGRPSKAKQHNMTKVTPRSIAYAAVVGRFSICGQDGWALEDGRYKLEDLFNNIVELFDDPSDSWCIETLEWWNKWVFGSSRIIETVASVDTSAALSSKATLQQQRAARRAAELAAINSGTGNLATGSGSTTGRGSLATNGSNSNERTTVEMAESDSELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQW6</accession>
    <name>A0A2R6NQW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000973">
        <property type="protein sequence ID" value="PSR74650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQW6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="284" mass="31584" checksum="6F5DFB305428B885" modified="2018-06-20" version="1">MEWSQLLSVSDLTVSSNIAPDVLSTDSTVPLRLSLVYTLYRPINQLLYTVCHTFSPHPLHKVSAPPPEGIPQIGEDLDGSNPFELALPTDMSCKMAKSKRSHAIVKSEKREVTPVAVVQMTCPACMSMQIATSANAQLFQLGGILDSQTTDLQFVRELDNCPLPDTDYATCVSLISDSKSGLYHINNGSQLVCIDIDDETTVGTLDNTFDIIVTTLSVLQGRVRDLEYEIARKNARHKQQVQELLSLKEFLQTRTDKLSCERDLAQHYCSNWAQLELHCQALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQY8</accession>
    <name>A0A2R6NQY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000965">
        <property type="protein sequence ID" value="PSR74681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQY8"/>
    <dbReference type="STRING" id="98765.A0A2R6NQY8"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="285"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="460" mass="51458" checksum="26559176917965C6" modified="2018-06-20" version="1">MDFPVKWNVSLQLWHREIIKTLPIGFQCTVSKALLPILQQEQVHLELPDGLRRNRESKVRATCDNCMTSIFASTWICRICGLEACSECFTPLSKLEVDQGANDAVIGPGLFSCTRKKLHRVGDFSPMSRFRKDELEKAILNMKALLKESTAKEVGETNLSDSIIDGSPTSVSNGASTKSALPSSIPSHGAQYFTDSDLTDVAFRDIWSKGVPLVVTDLLHKFRLNWTPEYFSTKYGEQACQIVECQTNQIKFVTVGKFFSLFGKYQGRKGCWKLKDWPPSTDFKSAFPELYNDFNQATPVPNYVRRDGVLNVASHFPSNTIAPDLGPKMYNAMASSEMQGSKGSTQLHMDMADAVNIMLYAASTPDGRQGSAAWDLFKAEDSMKLRKFLGQKFKGQFEDDPIHSQQFYLDAQLRQELFKEFNVMSYRIYQKPGDAVFIPAGCAHQVSDNAASISSASYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR94</accession>
    <name>A0A2R6NR94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v9249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000917">
        <property type="protein sequence ID" value="PSR75208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR94"/>
    <dbReference type="STRING" id="98765.A0A2R6NR94"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR75208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27422" checksum="7250090C62E56010" modified="2018-06-20" version="1">MPPGPRGLPLLGNIFQIPKKELWWKFMDWNREYDRPDVPMASEVLCGGLNFGFMPYGNLFGASAILCTTYDWSLYDSSSGLSVEEKDREVEKINSFVSVQSQAVVPGKYLVNSIPALLRVPVWFPGAGWKREGLKKNDWWSKKFLDLVGDVRSKVKEGRVGHCLAANLIENEEKFGLEKIETAWLAGVMFELDSVVGRDRTPTFEDRSELPYIEAIIKELFRWRPAAPLVYGDISLALSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS84</accession>
    <name>A0A2R6NS84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS84"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="13358" checksum="165ADB4D6B0F188C" modified="2018-06-20" version="1">MGAQLSTQHRHSKSSKSSTSLFRHSRGDDVGGKKTPSLGSIVLKTSGSPAQKAAQLQQAMPETSSTSSGTLVERSGADGKRPAAPPVKGPGNAESVRQALIAVYIDISAPLYEKCLATTAALAAVVAEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSE7</accession>
    <name>A0A2R6NSE7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v8906</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NSE7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="921"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="963"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1155"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="76"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="428"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="923"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1241"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR75789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1482" mass="161431" checksum="A027AFB622DD309F" modified="2018-06-20" version="1">MPRPTDLSIDTQMTNVTPSTSSSPTSSTFKLPLSAQESTQSVPSTTHEPPAGPNPSIRLLFSFLSRHDLLFLVAPAVFCSACSGAVAPFMTLVIGKVFDSFANFPLTPHPPESAKHQLLHDVGMTAIELIGLAIGTLTVKLSATLMSSLWIWTGERNLLAIRKHVYKSVTRKDLLWFDTKCEDSTGLGAGGLMAKFAKETDEVRTASSLACGTFIQHLTTTVVCLALGFSRSWALTLVILSAVPVLIFIQSLSQALASPRLNDEREHTAVAATLVDRAIAAISTVKAFNAEPHEAHSLGKVLDQLQKSANGCISVWGFTSGLSQFSMMAMFVQGFWFGAKLVRSGTISPGDVMAVFWACLIATSNLQMCVPQLIVIAKGKFAMVSLLTLVESSAQPTVLGRSPSSFSTTGAIRTTLRGIVPESCMGGVELCDVTFAYPSRPAMPVLKDIDIFLPAKETTFIVGASGSGKSTVAQLLLRMYDLNQGMIKLDEHDIAYLDMDWTREHVAAVSQTCILFDMTVHENVAMGLASPCSRRRPQDITRKEVENVCRAALMHEFIRDLPDGYDTKLGTGGANLSGGQKQRLAIARALLRDPTILILDEATSALDATSRILVFEAIKRQRHNKTTIVITHDLSQISSQDFVYVLKAGECVEQGYRSELECFEESEFCRMLRVQDVSGGFQEKTDEDLVNTNDMEVEEILEKQEVEKDAKLGAAGINAKTLGRQSVYRPLTMSNWMFDVVADLTKPPTSASAAPVTQPDRNTHRISRFVPAEAFTASPSPPVSPRRQSFINVPSIASPPPAYNTLSRRYSLQFTPSSPKSFTFNSTTSFASGTVMDDEDELEKDPLQVRVLRPARSTTTLASSIQPKRQRAKWDEATLAALTDVKVEKPVSASVDMQMPSQPSFWRLLVAIWPTVPLKPLLIAGILISLASGATTPVFSYVLSRLQYEVSIGATHMSAINVFGGISLAVAATDGILIGLKYFVLEFVAMDWVNNMRKACFDRVLKQDKAWFDKSTNSPVRLVQILIKDGDDSRSLIATVLAQSLVVIAMLGVGLIWALVEGWQLTLVGLAIAPVFAIVMSVQTNLVAKCEYRNKRGREEVAKHYYDAISNVRGIRSMGFEGIFQEKFDKAADDALSTGVRGAFVEGCTHGVSSAMIYLAEAVLFYVGAVLVSNGTYDYLRMVQVLNLVVFTVAIGSQLMAFTQRIAKSVQATQDFHSLLRLSNTPEESQGISRPPIMGDVTFKKINFSYPERPDVPVLKDLSLTIAERECVAVVGSSGSGKSTIAALLQRLYEPASGTVFIGEHNVKSTDIHYLREYVSVVSQQPSLFDATIAENIAYGNPSLSDQEIRAAARAANVHDFIMSLPKGYDTLVGENASLISGGQAQRLQIARALARPSRILILDECTSALDPKNQAAVMETIKSVKGGRTTLMVTHKLEVMRMCDRIIVVHEGKVAEQGTFHELRHSGGVFSQLASGGEWMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTX4</accession>
    <name>A0A2R6NTX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTX4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="19218" checksum="4AF7509EB3199DFF" modified="2018-06-20" version="1">MPDFYMLKLETIWLDQTVHFEQWNKFISDMRRDWEKAITPQEYLAQREGRCFGLDALALTFSMLSFLVAMSYVFFDATDSRTKCLLGLLLVSLTFVTLAVLYMDWGTVVPTRDSFWRRLGTSIVERIFNPRRYWKRDSKTLASVLRKLKLFFSGQIRDEENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU54</accession>
    <name>A0A2R6NU54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSMD12/CSN4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU54"/>
    <dbReference type="STRING" id="98765.A0A2R6NU54"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSMD12/CSN4-like N-terminal" evidence="2">
        <location>
            <begin position="939"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="930"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1236" mass="138569" checksum="04A0C36F3D5D1173" modified="2018-06-20" version="1">MTSPTPSLNRRSTLIDYLSSSLPKRTRLPSLRSRKSTASVASNNNRDSFYAPYAVHQQNMAPIILRDPEATARLLETILDAPGGRRMLCRLARTCKAFKDPALDLLWRDLDTVIPLVTLFPNALLKRARRPALGLIKNPEGSDWEAVLAYGERVRSITYVEAFNTISQTIFPIFEQVPREHLLPNLTSLTWKAETAPGLAYCKPFLNPQLKNFTLEMGVRAPRINEFLDYVLEKTQLTSFSFTLHSNLPDAFVEKMQPNKRLEKLALMAPGSLAAKVGRWTSGLPSLKNFQLDLTNSSTRAVEGFFSDIAPGDNDGDFSEIRKSAARLTSDYPRKDAFLTLTQLSLSGETANIATFLKHITSPLVTLDLAIEDPPARDDWQDLCRLVCEHFGRTLQVLRISASTASRFSELVRSTSRGGDVQLQHLTLEHFGPLPCLQRLEIELPESAIFHNVDLVHLARVCPNVEVVRLCGQARFPQSFGPPYLTLEGIIPLTSACTRLHTLSVVVNALDGRDETYKSMEISSRALMRLHVGHSWVKDALQTALLISHIAPHLETLKWFPHASRSGVVELHATNWQKVNDFLPPVQHMRLIERSLKPKPVIIEKPKTVEKEVDATVHTSHRGVQVKPEYADVDAQVAPQTADVEIEALPETHEVEIDATPVYVEHEVHAIPEFSDFGVDASPDTEEKAIDVFEPVVEEVQSVTDSEQPSESKTPPSTFIPSINDLVNLPLRVVQVYTYYLTFPVRYMLSFVPSMPTALANYADTEYEPKSPVPESPVTENGVNGVNGVNGVNGVNGVNGNGISEKHMPHMTHMSSPSLHELSADENDMDINPDIVHTTIDSNAITTFSVSNDGVFYFALEARREAKVSIKGHVGDTPLGAFYATRQSLGSARSRSAVNPLNHFHQMADPKKQEKDYTKEVDELLPQTKALAQSAKLQEAVDKLQVLEKQTRNASDLSSTTRLVKETCQLCYDARDYTLLNSSIHLLSKKHGQLKGAIQGMVELVMDWLDAVREREGTEKWLELVETLRSVTEGKIFLETPRARVTLQLAQYHEVLANSPTPTSPPTKESKQVASDLLSDLQVETYSSMERREKTEFLLEQMRFLIMIAREKDTEKGVEGKKDAINGGESEWIKVRVAGRKVNESFLTQKENEDLKLKYYDMMIQYALHHSEYLDAAKHYYKVWETPTIKAEETGRGKEALESIVYYVVLAPHDNEQSDMLHRLFNDSALSKLELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUY3</accession>
    <name>A0A2R6NUY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000803">
        <property type="protein sequence ID" value="PSR77277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUY3"/>
    <dbReference type="STRING" id="98765.A0A2R6NUY3"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR77277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="214" mass="23949" checksum="E638F25CD963E9FB" modified="2018-06-20" version="1">MDLYSSQNYHQQFQGQGDVNPYHQPYQGPMYSVPGSSSSAHTAPVPSNAYEYDVGILAQQSVYVPGAMIDKRGGAGGKLAKGGKRTTVLRKGAGKVWEDQTLLEWNPSWFRLFVGDLSNDVSDDVLANAFNQYTSFTKARVIRDRLSGKAKYGFVAFSDPEDFLKAWKEMDGKYVGNRPVKLKKADNAVNPVEIGHRKAKQLEKELKKNRHKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV16</accession>
    <name>A0A2R6NV16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000802">
        <property type="protein sequence ID" value="PSR77303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV16"/>
    <dbReference type="STRING" id="98765.A0A2R6NV16"/>
    <dbReference type="OrthoDB" id="2742885at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="327"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="882" mass="100977" checksum="81063861D8D423F1" modified="2018-06-20" version="1" fragment="single">MPLEEIEVPKQFRYDSKMITRHSEAIVHDNRWAILADQEVVEEGDYDLSSYTATFSAVMDTVCSSTGARVEVRDTEMKSFPRKIKKLLQRHKRYSKMLAKEVISLGGATESTTIRYRYARKAFRVARIAWQREQREKLYTRISDDFIAHDHKSVWRRVMSNVNDHKHGQAKSNGKAFAPVRKKPVNPKDDPLKGELLVNKMDILNRVTEHYRDLTEYNDDGKRDSDHWAKISLGEEEKQLLGINENLKWPEVLCAIRRMNRNTSPGMDGVHVNVLKSLVSEECMAKCKLDNPDWVRPDNVRVDLAADKLPTVPLTPLGKAIFKALEKAWEFETLPENWQEVVICNLPKPGSDPELCDGYRGISLLSVVLKVLLQIMTERLQDAAEKAELVAPEQSGFRRREEAMAQVIAIADIVRRRKLKGHSTFGVFIDFKKAYDRVPHGALYRVLDHLGVRGKFLNLVKHIYSNSTMAVRMGGITGDKFTMKRGTRQGCPLSPLLFILFINRIIKDCSSGGVRVPGLRKYKNPWQGMPGHDTEHYCEGGMYADDLLTLDRTVRGAQQTLRKIEKWARRWGMELGLPKCGVMGWITNDLDEEEFNSVQFLINAGTVPKVDRYKYLGVWFDPSLGDHRSGTSVFGGSLELHNSRFRAAEGLKAVHALRPLLLDRKCPLPIKVTLIRNLLLPLMLYGSEWTGFRQEHAAPIQRVVDMATRWAMGAGARSNSYAGFTLSTDLGIPSVVEEMAARRTRLWVKLEAGEKKMRTWLQILHDNDNINQNISEGDPLVHWNSYSWSRSGKNWIRDVWGPHDVSVWDVKVNVPDAILGTVATKYSGRSGKLNKYEFVSFLRRKKWVPEDFRIEMVDDTDFLDRRAEDEPQPLRPWAARMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV24</accession>
    <name>A0A2R6NV24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV24"/>
    <dbReference type="STRING" id="98765.A0A2R6NV24"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="153"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="562" mass="60378" checksum="CD8ECE22E822182C" modified="2018-06-20" version="1">MASDSEDEALEDLQYDDASDASEGIDEEILDALEGTLAAEESDADDDSDTDDTDDVSEDEESESGPGTLPVITNPPSRDVAAPSTATLSGTSHPSAPPSAPISDVPSPHGTLTPARSPSPAPRNRSLSPAGLRKAKLLADRKWPRSFTVEAICAIPHPVSTHALASSLCMSHLITGSEDGYIRDYDIFSAVNGKVFLTAPQRHHCGVMEGLMKAAQIKCWWENPADMRLAPGPIEDPPLSPVYSLLMHSDALWSLAGTEQGHINLFTVRHEPGRLCHTMYGHRGPVSALSMQYDERGFFSAGWDGEALQWDLNTGQVVRNFTAHGAQLAAIAVRPLSSDFQGVTWVGNRPSDLQRNTSALPIAVDGFTDTKRTSNDTTVSAKNSKSVSATVKQEEDAQSDTSFDPLFDDEPDTDAEPPNAPAPGPKPIVSAQPQRGAIAPKNAPPVLDPTTYASFSPDMLMTASIDGQVILWDRRVNSPRQGVGRLWMSEKTPPWCMSACWSADGSQIYAGRRNGTIDVWDVRLTGQAHMGTPRVLKTLRNPVSSGVVSCVVAFPDGKHIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVK9</accession>
    <name>A0A2R6NVK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protection of telomeres protein 1 ssDNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v7812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVK9"/>
    <dbReference type="STRING" id="98765.A0A2R6NVK9"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="9">
        <location>
            <begin position="489"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="9">
        <location>
            <begin position="620"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="762"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR77622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="830" mass="92058" checksum="5F037A49BB6346F0" modified="2018-06-20" version="1">MLKRNSRQEPETSRKKQKVDAVKEHLALDSAMEEAEEDPIFRHSLQRKVVDIYEHGADEEGFIHLKVKMKWPQIGGKARIQGEATENGNAVCFEITFIEASCKHFQSIGLQFEIGDVLYLSLKGVTVERKNVSKAASSKILPISLSFREGVLLRFLSKKTPPITGMFVDSFVVKSTHSFISTGDAPFEDDWFGTPHLVAVPSGAETIEVDGTNDGIARKACEATTDDATPDADSSGTKRVRVSTTSKKKLDSEMVVSIQRGVSVSSVPSNRAGIRPEPLPPASNAQLQQSRDHVPETKRPDAPAKRLYRDTNNVSNQKLTPAEVRQTAPAEGSSKPRVDGEPRKEPSLHANKKASKKAVREARKARKAAESTMPVLVEPILQATTTAVDGRIEDSALPAQIILEPPIVTPADDRSSEETSPYGDSGNKRPKATNEPSLSGSLTARNVEIQRPQVKSQELRVPPPIVPSALPLPHSDHDPALDLQAGLYIGEVLHGFQNENEVYSIYVTDYTANKEITPVNAPWCHHALADRVLKVEMWLEAAPMGAEMKPGDFIEINNIRMKSSSGGYLEATFSEGRKMRKLDADELEKEPHLEALLQRKKEWAAMAEEMGDRFPHKLFKDAEVDAHFGCTAEVLYISLKDNERAFIYVTDYTFRPDLAPIPATAEWVRDVDPDRIVKIALFQDQAETAKALKAGDIIAVRNVRLKQGLKAKVTGYLGGSERLIFKLQPNETGNVDCLELIKRKKEWTRELKLKREVAARLKSRQPKPVTGGGKPKKPAHDEPREILTIKEVENCTVCPALFRVVARIVAVWPPKIEDFVILHCTKCDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVU5</accession>
    <name>A0A2R6NVU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000770">
        <property type="protein sequence ID" value="PSR77870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVU5"/>
    <dbReference type="OrthoDB" id="2756261at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="242" mass="26819" checksum="83639057F2D137B0" modified="2018-06-20" version="1" fragment="single">MFAQFKSLGRPHRPRALSASAPSSDSSVHRQSVNGGSVPICDDMSDGSCQPDAPRGVTRSREDDAEDAREVKRLKTFGTQVARQVGIPADSLDCFVELEVKQMLITLMARIIALEAEKVCDENEELLRSKKFGRGLAKRVLACLLSPNLSAYVTEVTDHVVNFIRKNPVRFKVPLPVLEDPELVEVLAGLVSVYLTDLRSAIKQKMNSSIKKGQDIATLVARLVYKTNIEMTVSHWIRIAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWB1</accession>
    <name>A0A2R6NWB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v7526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWB1"/>
    <dbReference type="STRING" id="98765.A0A2R6NWB1"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015356299" evidence="8">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR78194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="146" mass="15584" checksum="963083786A6B4FA2" modified="2018-06-20" version="1">MNTHLMLVLWAVNLLIGGVAAWGALGHETVGYVAQQVHQFLAPKALSFVQSSLGSQYSESLGPAATWADDVRSEAAYSWSAGFHFVDAEDSPPSSCSVSESRDCGSGQCILTAIANYTTRVVKTSLNATQRQEALKFIGTTTYVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWQ8</accession>
    <name>A0A2R6NWQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWQ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NWQ8"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="133" mass="14729" checksum="8F51D8615A93F387" modified="2018-06-20" version="1">MPVVATVNAVPAPPARPLARVMVPDRVPIPPAPPAYQEIVVFPPAYTTLLNHSSIRNNAVASTSQIAGTRGIWAQTERERLVQEALENLRVNHECDHKRWKYRPGGGVCQTCSHRLPSYLFVSSMAPLSYRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYB9</accession>
    <name>A0A2R6NYB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="14">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v6850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="14"/>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYB9"/>
    <dbReference type="STRING" id="98765.A0A2R6NYB9"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR79949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="293" mass="31373" checksum="BA865A91686A9A0E" modified="2018-06-20" version="1">MFKYDSVHGRFKGTVESKDGKLYVEGKPISVFSEKDPSNIPWGSVGAHYIVESTGVFTTVEKASAHLKGGAKKVVISAPSADAPMFVCGVNLDAYDSKYTVISNASCTTNCLAPLAKVINDNFGIVEGLMTTVHSTTATQKTVDGPSNKDWRGGRAVGNNIIPSSTGAAKAVGKVIPALNGKLTGLSFRIPTVDVSVVDLVVRLEKGASYQEIKDVIKKASENEMKGILGYTDEKVVSTDFTGNEHSSIFDAEAGIQLSPNFVKLISWYDNEWGYSKRVCDLLVFAAKKDGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYG7</accession>
    <name>A0A2R6NYG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYG7"/>
    <dbReference type="STRING" id="98765.A0A2R6NYG7"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22413" checksum="DCEC73460869B6F2" modified="2018-06-20" version="1">MAPSFAQRSRIATDTLERIEAILHAVPEGSLDSTFIKGPELPPLTKISDEQTTTISVINSDAFTAARDIMRRFPDARGKTAVLNLAKERRVVSVITVAALRSPPLTADGEAFAWPASLNDMREKIRLVYRMAAHNAQEHIVLGAMGCGAYQCPTRQVAEEMKSILLDEEFRGRFRTVVFAVYSTGRNNNYEIFKEVLDGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ71</accession>
    <name>A0A2R6NZ71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ71"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ71"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47817" checksum="8B791730BF6D4F89" modified="2018-06-20" version="1">MEKFGALPRPVGTLRHGRSSIRTILPIAVALACFLFLVYGFAFGQGIKFWEAYSRARLSPQAAAAVSRCRSIQAKPAPPLDFAKRSQSDRFAPGTKPILLKNAKIWTGEKNGTEVVHADILLDKGLIKGIGQTNLAKILKSYKDDIEVIDVKNAWVTPGIVDLHSHLGDASSPELDGASGDDNSLHGPILPWLRALDGLNTHDDSYRLSIAGGVTTALILPGSANAIGGQGFTIKLRTTAERSPTSMLLEPPYQINNSFPDPDLPLRWRQMKHACGENPSRVYGNTRMDTIWAFREAYNKARQLKNSQDVYCSKVNAGKYEEIATTPFPEDLQWESLVDVLRGRVKVQVHCYEAVDLDDIVRLSNEFEFPIAAFHHAHEAYLVPNVLKQAYDHPPAVAMFATNARYKREAYRGSEFAPRILAENGLKVVMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ74</accession>
    <name>A0A2R6NZ74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ74"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ74"/>
    <dbReference type="OrthoDB" id="2504001at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="288" mass="32259" checksum="68B8CDD106EB624B" modified="2018-06-20" version="1">MSYYNAQVAVMGGSNNMVLRFVPHEEPSTTVPYELQPYYPADVWASRIPAVTRTASRYFKKGLEWIWLIVSFAALIAAPVAVYFVALHSLPDDDNSDDNNNNDHDRDRFDDDDRNSFDRYWKARLISFATWIALMIVVFVPMHMWKNHGKRVVNQMLINWENEDRAVRGPNAPLPTLRMKSPGVISKHIKLSVNIPPMAPSMYNPGSNVPPYIANGPMDPAAARYYGQQPPQNVGQWGPPPTSAQAPQGGAGFGGVPLYNPHDERVPGYSAPTLAYSDEKNPFEDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZW0</accession>
    <name>A0A2R6NZW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v6281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000609">
        <property type="protein sequence ID" value="PSR81709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZW0"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR81709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="786" mass="87661" checksum="D15DFAA93D1D9E24" modified="2018-06-20" version="1">MATIAVPSEFPLEKQGSMDSAMDEKLALDDKELESSIHGDHPIVDLKAAALSDQVGDVYDNVRAIDLGADGKERPIETDADYAVRLISLEDEPSLPIFTFRMWFLALGLSCFGAVLGQIFYFRPQTISVSQLFLQIIAYIMGKGMEEIIPGPYENARIRTRDNWFWRFMNPGPFNLKEHVAITIMASTASDSALAISIFAAQDLYYNVRPNAAVGIFTLIGSQLIGYGLAGMMRLFLVYPTFAVYPQLVPTVQLFDALHRGKSVVLQKKRLRFFWAIFVAIFVWEWFPEYIAPTLTGVSIFCLANQKSPWFTRIFGGAAGNEGLGAFSLCFDWAYVGSGGGAIGSLFTPLSTQMSLYAGCAVCMIAFCACYAQNIWHAQNFPFLTQLLYYEDGREYDQLSILNPDYTLNYDKLAEQGLPWYAASQLLYKISRTMYIGAALTHFLLWHGKTVYRLIRDAYTKEIDDPHYKKMKIYNEVPAWWYLAIFLGTIGMALATAYTAKSGLPWWGLIVALIFSAAFIPVVGTLNCTVGYAPSIENLVQMVGGAIIPGKPVANMYFTLYGYNTLVQSLNLLRDLKLGQYTKIPPRVTFTIQTIGTVIGALLNFVIMRTVISSHREILLAVQGSNVWSGQQVQSYNSDAIAWGALGKPLYATGTRYGFVPYMLLAGLGFPIPLYLLHKKYPKFGFNKVFTPILVAELGYLSVGINSSVFTSFVLAIFSQWYLRKYRATWFRKYNFLLSAALDGGTQVMVFVYTFAVGGGSGTVRPFPTWALNPTGNPDYCQRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZX8</accession>
    <name>A0A2R6NZX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000606">
        <property type="protein sequence ID" value="PSR81821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZX8"/>
    <dbReference type="OrthoDB" id="3263050at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52943" checksum="E9A0A05FA15E60FE" modified="2018-06-20" version="1">MPDQSSLAMIPQEVLEHIVFFAATDDFLGPPSGILPFLAVNRTMHDALSFNTNPHLYARIFAHKYDLAPAIRRMGADLFPATALAEELRRRSIVLKRIRHRLDSKRGTGERQIRRCSDNSQGAGEEHIDTLLWTAYLMMLESDGRNERQLREYARVNEWLKEYWFHESGASGALDIVKNADEWPENTERMSLATWLFWYMLEPEEYMHDDNLFRDATGILKVLALGAHKYPSCYPNWQDFVPKRSKLHPSLVRHFSSDIEVIAPAPASPAILAYLTLVNKLSVSWETTNYMKPLFPAVDIDRSARKNTEWDCDWARIHSLANPRILLGNTLSRSFTPGSLEGVWEGIFTYTEFTSYAALLSGAPPSVLQRSLVAQHRQTIKVREWHLLAPGIDEHEPTRNVTPLSPGNPSRAYVPDGVTISEVTDGLEITEPGRERVIYHSWSSTQKTNALGRVKDIFLTGEVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0U3</accession>
    <name>A0A2R6P0U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0U3"/>
    <dbReference type="STRING" id="98765.A0A2R6P0U3"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="275" mass="30061" checksum="AFAF1BB88269784A" modified="2018-06-20" version="1">MTETAVVDEGIRVVVLPSQASYFAGEPFSVTVTITNIRAAETTLPSRSASQSASRVHRRGAHSVSYVPMARPPTSPGIRTAMSSGPSRPLDGEAMVRRGVIGQPLLTKGAEKQPDLVDPTRRRVTLNKSLSVSITTHDFRSDSQDDPKGKSPLRALQAEESAVTCTETFSLELDSTNGDLRRYTENLLASASTKARVSGGAASGEPSDIRIPAWAYRNGDGLLYSEDELQEKETSCREAVDVLTRNPKKRELYEPLSSDHLEFWITIMIYLLAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1P8</accession>
    <name>A0A2R6P1P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000557">
        <property type="protein sequence ID" value="PSR83536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1P8"/>
    <dbReference type="OrthoDB" id="3235847at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="34978" checksum="22CF96452FCFEB82" modified="2018-06-20" version="1">MATIPLPPGLSLDQYLTLQGQLVTIAITVAVAMAVIGWDYMVLLPEEIALYMNFDKKLWRTPTAWLFVALRYSAFIATVPSLFFTSVQNQHCQAAVVISTLGGVLVVASSGLIFCYRVFAFWHENRIVYGTVLLFYAGMLGCWIAVAVHYKAITGPTTPFGSNCQMEPIVSWAPISYASSVVFDSVVLALTLAKVHSSSMPRSNLGEQISRDNIAYFTLATATNIAVLSIQALGSAHDMIKPAAVPFSTVMTVAMGSRVYLNLKLYDKKQQNRVSSFPLTPPISPGFSHFSRDRASQSPQIIPTPLGSFAQTAYDDKSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1R9</accession>
    <name>A0A2R6P1R9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000557">
        <property type="protein sequence ID" value="PSR83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1R9"/>
    <dbReference type="STRING" id="98765.A0A2R6P1R9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7521" checksum="11F4563C02F5F5FF" modified="2018-06-20" version="1">MPIKPLPQFDNAEAAKLHVPPSAQVLKLMKIEDPLLRSGYARLSLFPAATQKLYPDEFEKGREMGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P211</accession>
    <name>A0A2R6P211_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P211"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6755" checksum="FDB3667400F83F3D" modified="2018-06-20" version="1">MKLFKLRVSESTGTPLCIHTYRRQAGGTELAPIPPTCPLATCFVPITSYRVFIKPNAALGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P223</accession>
    <name>A0A2R6P223_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v5564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000549">
        <property type="protein sequence ID" value="PSR83948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P223"/>
    <dbReference type="STRING" id="98765.A0A2R6P223"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR83948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="206" mass="22959" checksum="8D8D565C3BBC38D6" modified="2018-06-20" version="1">MEVVNQRSALLSNFEVLTLLRELESDHLARTRTALRIKKEEESVGSPTKNHAPIEEVLENLRTIEVEAIQYLAADYQPTASQTEAGIQQLTRGLSPYNLNKAEKLQIVNLAPTEAVELYVIVEELEDRFGARIDDILSTVRESLTQPAPAASRPSPVVSMTDRTRKTEEKGYAANDIAWDYEENELVFDDTGEGAGIEGDLDVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2B5</accession>
    <name>A0A2R6P2B5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000552">
        <property type="protein sequence ID" value="PSR83730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2B5"/>
    <dbReference type="OrthoDB" id="3265353at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="116" mass="12089" checksum="CBDDC455E95681DB" modified="2018-06-20" version="1">MFSSNSPVRPDKVSFDDMTTVSMGVKAVRDIPAGSCILSLCGSMSSDTVEGNITVSGYGGYGGGLCVCATCNPTNPPVAKKRTAPPQPQQLPSKKKKPRRTGKENKKPKELSGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8P8</accession>
    <name>A0A2R6P8P8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000516">
        <property type="protein sequence ID" value="PSR87211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8P8"/>
    <dbReference type="STRING" id="98765.A0A2R6P8P8"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="115"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="333" mass="37468" checksum="222665B33365A40B" modified="2018-06-20" version="1">MENIPYNHGWPESWAIILEVRSISEERSVSSEDRDFGGLSRDHWHLATVLHGFDPRIYILSNSIRNTPAVPKNISQLLPTQVPDWGINESAESLKATWLGTDTPTLQILNKRYKPHVFAPLGNRPYLESIGIPSSNIHTLDWWDSCNVTLSIPSAASPDDRISTAFKVTCTPCQHTSARGIFDRAATLWSSWAVEQVLEGGDRQGKKVYFAGDTAYRTVMEHEDENEVPVCPAFEEIGERIGPFDLALIPIGIRIFQDVKAKKALAMHWGYVSYFLLSSYALAHSRPSDTRTWVLTTEDVMEPPRLLKKERDLAGVAEEDFDICGLGETRIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJG4</accession>
    <name>A0A2R6PJG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJG4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR92204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10500" checksum="66840249DF1E5CAC" modified="2018-06-20" version="1">MSTTSRPMTPAPGSPSSLHNATTTIDDLTIAFGLKVDAEPASDGQLGQTPYTSPLLSVQSPENKRTEEQVDARVAELVRENAVLEKVCCKSILKDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMT0</accession>
    <name>A0A2R6PMT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v4614</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMT0"/>
    <dbReference type="STRING" id="98765.A0A2R6PMT0"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000024">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR93719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="163" mass="18443" checksum="2DC6F1925BC80EF1" modified="2018-06-20" version="1">MGLSVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRERVSEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLHGLRQRTWFIQAACATSGDGLYEGLEWLSANIKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PV81</accession>
    <name>A0A2R6PV81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PV81"/>
    <dbReference type="STRING" id="98765.A0A2R6PV81"/>
    <dbReference type="OrthoDB" id="3241030at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR97094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20142" checksum="B51EB1C3057945B3" modified="2018-06-20" version="1">MAISVPFASISLFTPTIISGLGYEGLNAQLFTVPPYAISFVVTLLLAWQTDKHNIRAWGSVFALAAAGASFLAQGALPPDAFTARYGLLCVSVTFAFACVAPILSWLTGNLRNTGASTLAVPLNVSIGQFGQIIGVNIYKTSEAPGYPTGHFTNAAFLIGSAIVVLILRGVYVHRNRQLVGQDGALRWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVK0</accession>
    <name>A0A2R6PVK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVK0"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="163" mass="17702" checksum="1F9224A8E3354693" modified="2018-06-20" version="1">MAAANDISVALFHRNKADRFHWAITISVSPIVVVKFHARNTAGGFWSYQTDEQQISDSLGLVALVKIGSLSATRKTVADVDELLESLDMATSRQDGGRSVKFDCVIWVRQAVRALDANGFLHCTDVLALEKECQEVATKWAPSVMTGDASYIVHVSEHAAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVM3</accession>
    <name>A0A2R6PVM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVM3"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="334" mass="36838" checksum="F33093BDB98D3079" modified="2018-06-20" version="1">MSTALFEHSYYIGNYMSGILYGVEVVMYFMTVRQLLYRRTTRASYKFFLAYSTALILLLTIDIAVNAVWAEQMWITFRDAPGGVPEYIGTQLSDWYQAWGSSAAVALVFMSDALLIYRLFIIYGSNFLVIIFPILIYIAAFILAVLELVSSFSPGGFFFNGSAVNFGTPYYSLTIGLNVIVTALICYRLLSLSKLVKHTMGPENAKLYTSVASILIESAAPYSITGIIFLVPYARGDLVSVALGQVWAKCTCLAPQLIVLRVVSDRAWTRDTIDQVHTGGFSFSTRSRHTGTTNEVSMNQLSKRGTDVTQGSTLAESYTKKGNSAATLAEVPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYY3</accession>
    <name>A0A2R6PYY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 2">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYY3"/>
    <dbReference type="STRING" id="98765.A0A2R6PYY3"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR99057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15321" checksum="163866580625B6F2" modified="2018-06-20" version="1">MSKPLGPVLRELLDQNVAWADAVDVQDPTFFERSAIRQDPKPLQTTNWPPPAPLDTWLAPLRELALSYPTPPSVLELVKANIQQQVMNLLKLPVVKNAWMGGKLKGVRGWIYELETGHASDLGINVVLGNSQELTCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7F4</accession>
    <name>A0A2R6Q7F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000386">
        <property type="protein sequence ID" value="PSS03509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7F4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7407" checksum="85382F8A81CEBDC3" modified="2018-06-20" version="1">MAPGAATPPHFKSRYPGITLGGRHSLNAFVGLSRSSSVSLFRRFACTLQSTRSPSISSLPSIIFALATKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7L9</accession>
    <name>A0A2R6Q7L9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000382">
        <property type="protein sequence ID" value="PSS03723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7L9"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="439"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS03723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="899" mass="101440" checksum="FA111C2606CA7A1D" modified="2018-06-20" version="1">MPPPRFNLAPQAPPGTQLPRNTFPFAVSNAPVRGTPRTDGMLKSNHKNETVHPYVKRDVEAAKQIPFYAWTEGALNLTKADIDTWASAIDELNWFQDPIIEDALTEFAVHSNREVHRYIPFVTIANRILELAKGTLPDVPHSYPIDDIQFVKNDPTFLLRIPEHGELAAFRRPDILVLRGVHAPLVGGARSPGVAWSDVLAFAEFKRCRKNLRDLLAAVRSGSLPPVIESRDATPELDDLEPPPEPTPPPRSLRPRPSYIDPDCEMEEDDSHSSAEGSEDNDSSNQSSYHPGAKPALRNFLQIAATGDSAMDIRREPVIQAGGYALETAACTYGTRLFVHGIVIEDDDFAFWYYDSSGYLRTKHTLSLFTDFSRLAAVLVGFARGDASQWGALPPVISPPSSGAYPDHFPPKSLADHSFDMTRPRRKGVIRVTLKAPIFAQYGLVGRRTFLYKIETNSVIADTPLVVKISYQVVGRKPEHDVLAIANKARVGHLPEVHMWSDLWKLSDGVRQIFYERSKEMSKDETNIATYEDRVLRALVYTEYLPLNTLFSDPDNLKLIPVMATQMLDCLHDLRYKAKILHRDISCNNIMYEMRRGKPYFILIDFDFAAILDAKRKGRSSVGATSKHRTGTLPFMAHELLQDMTRMSMPNYVFRVVHRLRHDYESLFFVTLWCTITMPEITDKKLKKRLVDYVLQWETSTVDSISTFKSNMIRQLSPVCDVPLPPSAEFLRPFFSMWCVQFYKGYRNLDDKTCNSMEEDYLVLDEDESTQASVEEFDIETLGGFISRDAIMAILSRTKGWRAINTEAVKELRTKSPPGFKKARKSPKVATATRSKSDRARKASTTRKVNVAQKSQRTSSPQRLSPPIVIRNSVKAVPVAKNVTTTSTRVTRSMTKKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB53</accession>
    <name>A0A2R6QB53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000379">
        <property type="protein sequence ID" value="PSS05350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB53"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="12385" checksum="736E7148F1D4D8FD" modified="2018-06-20" version="1">MSANPEDLSYIHRRCVLVDELVSLEWAHPPYDAEGRYDLPLISVRMHRLRDLAEAVYTDLEAHPEVPRTPAPCLPFDLVTRIEGEMKCGRRVRRRESARTEVLSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBK2</accession>
    <name>A0A2R6QBK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF572-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBK2"/>
    <dbReference type="STRING" id="98765.A0A2R6QBK2"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34910" checksum="8FF8B7F8BE31E84C" modified="2018-06-20" version="1">MQGFNKYYPPDYDGEKHGSLNSYRGKHALGDRARKLDQGILVTRFELPFNIWCGTCDNHIGMGVRYNAEKKKIGNYYSTPIFSFRCKCHLCGGWFEIQTDPQNTRYVVISGARQKEEDWDPEENGGYAIHDTDPNAGPVDPLAALEKTTAAQNHMNKVQVPRLEELQSLADHYGSDPYSLSRKARKRFREEKKIDKEKQAADDELKGRYGLPETLALSVESEETRSQAREDWLQARNEMKLLDGAKRRKLEPVGIVPRTFPKSISSKHRSSQSSAASSSTAVDLLRARILLNTARRKPPDARRLARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBK9</accession>
    <name>A0A2R6QBK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBK9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="14689" checksum="5FBA9626EB4E7A01" modified="2018-06-20" version="1">MTTLPQTLREDRKMKEGTAEEEEFDNVFTIRKFAYLGPNVPIVGFSMHRRYMGGSVHGIPLTGFTSRNQYHHPQITKSLDVIMPIMLMGILLQPDNQTSQDGRDDSESLVLYYFLPGPSISIGMKLQMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEM3</accession>
    <name>A0A2R6QEM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gelsolin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEM3"/>
    <dbReference type="STRING" id="98765.A0A2R6QEM3"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="325"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="406" mass="44826" checksum="7E89E522277C87BF" modified="2018-06-20" version="1">MADTDHILLNRPTRYNIEDSNIALLGSDLEKHVREQAGDKEAAWDAAGKEVGTQIWRVEKFTVVEWPKERFGSFYDGDSYIVLHTYKKTPDAKELSYDLHFWIGSESTQDEAGTAAYKTVELDDREFITLLDIALCDSLATTVAQPADLNGQPVQYREIQGFESPKFLSYFSHFLCLRGGVATGFHHVSTPPPDDTRRLYRIISTGTRLLVREVPVEGASLVPGDAYVLDMGTKIWQLNTKGSVGKEKFKAAEFAQSLVNERGSTSPCDVTVFDEGGHGFGTFLAEVGLEAMPSTAERDIKRSGKPQTLLRLSDSTGKVTFNSVDPTARSTLSSSDAFLLDDTSNVIAPAIYVWIGNEASLTERRLALQYAQAYLYEHQEGGHAATSIVKMKEGHETEVFLHALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QES0</accession>
    <name>A0A2R6QES0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QES0"/>
    <dbReference type="STRING" id="98765.A0A2R6QES0"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="353"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS06626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="618" mass="69802" checksum="F27DD642769EC6CC" modified="2018-06-20" version="1">MHVDDVFCPDSSLKTTTPLPAPIPQRAVGGEIERIRLQMAADQAARLHETESRRPEYLKRAKRPIPDSDFTSENQENTYPTLGVTESPVKGRRLMLFQETSEESFEQSLLAGGYLQYGLAPAYAEPSTPRINGKTVPEDGPQQVPSDREIKKRKRLAAFQDHNVSTSSRLFPVEIEGRGRVILDKLPEEIVPQSDHPTKKRANRRKKGAIVDNPGKKKQVETPVVETALVKPNWLDEVFPWSLRYQERMELGKREEEEKLKWIERYLERDSDDEDDEDQSLGLPPDFDEEEEPQFRRGRGKMVPLPINPDEQKRIRAKRATVKFPCDPADARAALLSKRSVRALAFRRRQEEEVVCVCNGKDDGRELVQCDQCETWFHLQCIGIEKISDLGREEDPWYCMDCLGITPRSSSPTFVPTDDRPPVNGRRDPLFFQGSVQESPPAMPWSATRIPKTPVRGKDHTQVFSSRSSWGESSELEPQTPSSAARSTRIYNAPSFVDPLDEPFDPTSTPSRGIKFSGPFTTPKATTLWGYKSAQMYTPSRSGCKLSGGPFPYSFGSSDASSPYRTVYSNDESPVRRSKPPVPRRLPDSPVGPKLELPPSFDPQESPIPRKRTLGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF08</accession>
    <name>A0A2R6QF08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000350">
        <property type="protein sequence ID" value="PSS06875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QF08"/>
    <dbReference type="STRING" id="98765.A0A2R6QF08"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS06875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="306" mass="35546" checksum="0586FD836898B1D6" modified="2018-06-20" version="1">MVDQMLDCLHDLRYKANILHRDVSKNNIMYEMRDNKPHFILIDYDLAKEVIGLDAFRRSSIGTHRTGTLPFMAYELVEDMANYGLTGHTPVVHRLRYDFESLFWVALWCAVKMPPGADHSENKILKNIVKEWESGLLTMLASHKKSLCTSPYKIDLIQLPLSSEPLRPWFREWCAVMKKADLCLEQYKEALKKPSRRPPFDMETVDGLLIRDTIKEALARSNVVYNPEELVELQDEDEVEHIACNVPCDEESNDPYDEESNDSYDEESNDYQQAQRCCSLSWFLDWCWPEQANYPLALDAIPSTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM36</accession>
    <name>A0A2R6QM36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000326">
        <property type="protein sequence ID" value="PSS10454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM36"/>
    <dbReference type="OrthoDB" id="2797156at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="262"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS10454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="483" mass="54250" checksum="1706B304F6E2153A" modified="2018-06-20" version="1">MAGSSSSRPNMHTSRESWDTACTKDIEETWRTYARVPSLASVIPPGAATILAQSDASLLQVQQDTRLICEMQQDLAKTASRRFAEDGFEREWKIMAPVKRKEVILEGIYRTMSLPDMEDRRRWCPDSTSKYLASQNGDAFLRMLKGLLPTDLYASISVPIDIPHPVVDRFFTLSPADERKPGFKTIIRLYRLSRIYCLTTIVWNTFLAFYGEKETQLAIKPPKADRAADAKFREDPQGLNSTQVRDVMKQHNTQRKAYDHACWKCSKSERMFEPGQKLQACSKCRAINRLVFYCSRQCQLDDWKNGVPVPHKQICGKLMNEDSTVDSALNSDEVEVSWLPKADASYKRSPALLHQISLLRQGDGLDYVFVLPGSTGDDVGARFWPIEEKIQFLIQRNRAFRTGDPGAVSKMFLALCGVAATSSVPVSNELVRNQLENQYGVVLSEPLLSEEGPEPTSEEIMFAMLGLKDQIARSNAASATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIJ0</accession>
    <name>A0A2R6RIJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000251">
        <property type="protein sequence ID" value="PSS29840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIJ0"/>
    <dbReference type="STRING" id="98765.A0A2R6RIJ0"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS29840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="128" mass="14198" checksum="75CD4CE647789AD7" modified="2018-06-20" version="1">MTKKRRNNGRNKKGRGHVTVVRCSNCSRVVGKDKAIKRFTVRNMVESAAVRDISEASIYPEYVIPKLYIKIAYCVSCAIHSHVVRVRSREGRRNRAPPPRVRWKDGKKVNPAVAAAEDAKAAAAGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLI4</accession>
    <name>A0A2R6RLI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000236">
        <property type="protein sequence ID" value="PSS30893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLI4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13726" checksum="E2F9A56FECB308B4" modified="2018-06-20" version="1" fragment="single">TTVISFQKTRSVTKPPDVRGMNKFIISEHPRIPQPVKVWSTALANVNRAKMSANNWGCWVREPHVLVGPENTLRVQNCLCNWFWVWDAWYHMLAAMGLFGAFGEWKPTYSASLLSDYNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLZ8</accession>
    <name>A0A2R6RLZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000222">
        <property type="protein sequence ID" value="PSS31029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLZ8"/>
    <dbReference type="STRING" id="98765.A0A2R6RLZ8"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="153" mass="16606" checksum="CEEFBF242383E176" modified="2018-06-20" version="1">MAALFEEEESEESNRAFDIGYTQQAIHEALGTDKAKIPPSEGHTNDKPTDGASRPSEDGHPAAEPRPLEELDLLLPKICEALVLVSQCLISLTLYSEERFSAAGTCAGKEPKLRRFEEHLKDYVNDSMSPAGEGSIECLIGAKVLSGFRVSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPW2</accession>
    <name>A0A2R6RPW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000201">
        <property type="protein sequence ID" value="PSS32070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPW2"/>
    <dbReference type="STRING" id="98765.A0A2R6RPW2"/>
    <dbReference type="OrthoDB" id="2745253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="386" mass="44152" checksum="F8AC75EE570B014F" modified="2018-06-20" version="1">MGEVPRVLQLIAATVMLMGNLNRFVCEHFPECVPSLCSVLSRPITSTLTQLCISTVRTTYLTIGIEGIMSTMEPNLPFLTAIDLCAYFITAHPTAYAEFFQRLLASRCHKLVTLVLRARLEDVEYLLQTSDNFLSLETLVVHFSALAIRKLALADGIHTLQILEGSGYEESEFEEVSIPQGIFPRLQTLSCPANRLLAFTSNRMERPYLTTVRLDDAFFLSKGRLPRSHQWPLWESLHPNLLTLQHSTKNLVDLSFCVPELDVHALLAAGLEFPRVQRLTVCTWKDPLNVQCLSEDEPIRQFLSGLPSLRMFRLSDGPMYEDQRPAKLFSYESHIAFQKTVVEKWGMSSSTLNHIALTTAYEWHRQLGSWYREGHERHLHQIYHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVR1</accession>
    <name>A0A2R6RVR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000154">
        <property type="protein sequence ID" value="PSS34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVR1"/>
    <dbReference type="OrthoDB" id="2692485at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="204" mass="22389" checksum="B2FE7E128E102453" modified="2018-06-20" version="1">MAESGARPQQITAKLADPANTAQPAVFHQKAIAEHNQQQLDAQLNVSQQRLPSTPQVSVECIPKIHQGTSLPLVDPPSFNSAAGSEEQLDEDVTVRDRGKKRPLVVESSESDSEAKSAREKSLREGNRKRKRKSKGQKTLRVQPEPDAVDADDFLADIDVPAVKPATSPAEDRSRNVNNFFGQNFDSIGVNGITKKYRNCMVCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVT5</accession>
    <name>A0A2R6RVT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pseudouridine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000156">
        <property type="protein sequence ID" value="PSS34100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVT5"/>
    <dbReference type="STRING" id="98765.A0A2R6RVT5"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS34100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50271" checksum="409FE7EADFA65B37" modified="2018-06-20" version="1">MADPSTSTLKRPAPEVTDIESKEPDSKRYKYVDETDKGVVKEGGGTQAGEDRAGKKEKKNFKDESRKAAREFHASHKKRRGTRPEGEARVDDGEPKAPRQPKRHCALLIGFCGAGYNGMQIQPNVRTIEGTLFSALVKAGAVSKDNADDHAKVNLSRAARTDAGVHAAGNIVSIKLITSVPGVPDMVARINEELPPEIRLWNFVRVQNSFNARTSCDSRKYTYYFPSYLLIPSKPGSGLYKTLSEQAGTSDEPPHPFWADTPPDSTREDDLQKKRQWRVPPEYMEALRSVGKKYEGSHNFHNFTVGKDFGDRSTSRFMKSIEITDPVVHGGTEWISVLFHGQSFMLHQLYGPRTLFIPKMPALGLLLEYPIFGTYNWRIENTNKGLTSSDENYRPLIDFEVHREDIEKFKQEHIYSRMRTIEDRDGVYVILPPGHQNRSMVTDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW00</accession>
    <name>A0A2R6RW00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000140">
        <property type="protein sequence ID" value="PSS34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW00"/>
    <dbReference type="STRING" id="98765.A0A2R6RW00"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005365">
        <property type="term" value="F:myo-inositol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17360">
        <property type="entry name" value="MFS_HMIT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="542" mass="58682" checksum="1FECDE8A748ACCB7" modified="2018-06-20" version="1">MNSSEDIQDMSEVKESKESYIETEDIAQLNAAGEISELAVIAEGEERTTWFVWLLVCCTSISGLLFGYDTGVISGALVTIGSDLGPAELSSGQKELITSATTLGALLGGLIAGALSDYVGRKPVLAIADIIFIGGAIGQAVCHTVWSMIGGRFLIGFGVGLASCIAPLYIQELSPTRLRGRMVVLNVVMITGGQVIAYGIGAAFEHLHGGWRWMVGLGAVPAGTQFFMLFFLPESPRILLRRGDIDAAKSIMSKVYAHATPQQVDLKVTALRSAVRRSIEITNSTTFMQRVALILRNPVNRRALIIGCGLQAYQQLSGFNTLMYYSATLFKEIGFNQPTAVGLIVSGTNFLFTLFALKYIDIIGRRKIMIFSAPGMVVGLVLASISFFYLTRHTGGNLVDGSHYSSTWSAIVLLAMIFYVASYATGLGNVPWQQGELFALEVRGIGTSASTFMNWAMNLLIGSTYLSLMDRITPAGAFGFYAGLCLLGWIFCVLCFPETAGLSLEEVQIVFQHGFGVKESQRLRKEKQAVVLREKQGKRGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW30</accession>
    <name>A0A2R6RW30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000142">
        <property type="protein sequence ID" value="PSS34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW30"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6925" checksum="680AC8E929643826" modified="2018-06-20" version="1">MDDFGTSLNTRRLDKDTKRIPSAIDKDVRYRRGCRWIMLLHGKENLRRADVQVLPVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZC4</accession>
    <name>A0A2R6RZC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000127">
        <property type="protein sequence ID" value="PSS35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZC4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="7010" checksum="479CCDA1E97FCF35" modified="2018-06-20" version="1">MSNTGVQPTAHYRKERKPSKVKPKPQIGKVDIDDDSFDDNMDYWNGSTNDWGVEEKQLIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3H7</accession>
    <name>A0A2R6S3H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000104">
        <property type="protein sequence ID" value="PSS36831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3H7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="17365" checksum="550E20BBD2A9D278" modified="2018-06-20" version="1" fragment="single">GGFVALTADDGEEKQRVGKEARLLAGAPLGARLDVGIRSRNSPGPYTKIPPLKFNPLNRRDTCRHTRAVSISQSLVFDLIDFCDHPQESAAVKTEMDDLTTCIACGFGLLITLLLVALKNSVSSTDGSHIQEHCKVFGSLQLEFCKTLGIKTYELFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3P7</accession>
    <name>A0A2R6S3P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3P7"/>
    <dbReference type="STRING" id="98765.A0A2R6S3P7"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS36892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="615" mass="69022" checksum="262492CFD93EE69F" modified="2018-06-20" version="1">MQHLYDTAAFWGDKIVSWTNDPNDAFWLAQTYFLTHQYSRAERLLTRPFPTTPPNIPRGPSANGHANLFSADLKGKGKEVPPFVLPITAAPSHPRLPVGGPGEMINVAAEYQDGVSRLVDMSVACRYLAAQCQVRQGKWADATEMLGEANPFRASGNSGATVPNMDGGIKIEASMCHLRGLLMLKLNRGDQAKHCFMEALALDVKCYESFEQLISGEMMTPDEEWEFVQTLAYKEQTPDDAEFVQMMYTSRLRKYKHTEEHALARRKLVEDYALGDNPDVLYSFADALYAQFRWADCFAITSRILSMVSVHAPTMPLHIACLYHLSHLHSKLFMLAHELVEREPESPISWYAVGVWYLTCKKWSEARTYFSKTSLMDPRFAPAWVAFAHTFALEGEHDHAVTAYSTCARMFTGSHLPLMFVGIEHIVLSNQMLADEALYAANSMCDGDPLLKNERGVMAYNHGDFEGAVALFQEALQLAQVTQSSEQAWSTTYINLGTCYRKLKRYPEAKNAYQRVLRLDPRDAVALGFLGMVYHLMNDLDAAIMKYHETLSVDPINGQILELLNLALEANVSAGPQGPKGSLAGDDEWTRKMREHRKRSATVERGATGEDEMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3R6</accession>
    <name>A0A2R6S3R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000091">
        <property type="protein sequence ID" value="PSS36930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3R6"/>
    <dbReference type="STRING" id="98765.A0A2R6S3R6"/>
    <dbReference type="OrthoDB" id="2673461at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="222" mass="24460" checksum="ED4DAF87836404F0" modified="2018-06-20" version="1">MSTIAFMGLAILTITAIICLHTYVLTKFMLLTNQIIKSNQASTYNSGWGSYDNNNNNNNPEAYGFLDPDDVIQGAHIIPAFVHSQSSTTSTGHQNAVLVESEKDSTEGSEWYNYNSEWRFFYVNFFVDKDMLMHYIGGGVGHSVITIVNEDTVDGLEQPENDVDMVSQSLVELDADSSDNKPEEIAVKSETNETGANDGDGDPEDGEGGVTEEEYLEGYAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3U3</accession>
    <name>A0A2R6S3U3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1164</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S3U3"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1295"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="921"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1433"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1558"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1232"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1560"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1578"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS36948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1634" mass="179282" checksum="7F738A1B6CF2F1FA" modified="2018-06-20" version="1">MATSLDGGDSPVLSPMSISSTHGSSSGDMRFHLQTLLDSKEKQLQQAGTLGQQLLAQRMELEERVGQLQEMDFDVGDGDEVREKYRELADIIKAWDAENEQLSNAFGLKLLNGTHSSPPVDIPRGEIERTVERSKASTSGTTAAQSSRRAKNAAHRADDVEFAFEIGSGLLTEVRRLQSLLAERDKAIQDMKEEKDDLEKTVESLRTALREQEQSSDKFKEENWNLEVTLQDLRTQLSDSQATVQRFEGEQKRLAKLLTTTRETADHHKGEAERQKNAFEELKHKHETAVAQFRREKASLQREKSDLQQEYDAERAKNAKISLRQHRFGSPLTPNGTTAPDLATPAHEEDDIFGATGGASTANRKKFDTSGLLPLDDFDFADESPDPSPSRPFLAPNHPSNELEVAQQRYAHLQRQLNTQSRALQREKEQKLEWKRKYDLLTSAQADDDEEEEEETIQQSSLEDSKPKARLTPFRSSKGRARGRGRGGLTLLQRLAAHSPDYADEDDLPDVPNETGLPPVLRGSSPYHSDQEEDRADSIQSPLSRAALKRTSTDGMDPEFANVLRQSTSPRSLSRSASSLRRSVFSKSPRGKVLSRRPRGGAAYQEARPPSFAGEPEALANELSQLGFGDMEDTLELPEPVKTAEMGCQTDFEEPVLPAVIVTEPSNPVIPFTSEIGIQVDPTPVLLPAKSDMSLQTDVEVVLVRLEAGVQHEDQTPVPLLVTSHASSQTEWEPPVHSEAGVQHEDLTPSSSFVSAGMMTESELVLPPTTHAIPLGTFAQAEVQTSVVLSVDMDVQTIPEVVPSKADIDIQTLSTPSPMSIEEAIQTSSFAFSDVEVQVAGPSREASLADSSIGDSSGEATVMLHYTSVATEYIEDGGIRTETASIIETDTDDYMDARQSMSLVTPTESFDDYHSIMTVTDNDFSESDDDGQSVKTSRVSSRQETPSSPIALPDPPTVPTYESKGVSAEFEAETISADQTTDDPKPDFKEMSIQTDDWTPDLLSHITPSSPVPPASPSVFRVGPSSQQFQFISPPPSTGPTLASLPTVAPPSPNAIARDSFIPRPRTSQSDRRQSIESTLSSAVDEIMLRSRTPSNVPSVVDKSRPPMMALPPPPRQPPPPNSMLPPPFIPDRRQPTVSSTSQDVPPPRPSSPPPVELIQRATTPTFGAVLSVPGANRTFGLRHHSSNVPTSVRQPPSTSSFRSAGVASRPPQSSPSALSFSIQERERREMSTTSLTSAGHSIGSQRSSVSSEHYDQPPRRLPDPPVTPDRSAGFSARQAAGGSTDPTVIHAITQTMIGEFLYKYTRRTIGKGHGEKRHKRFFWVHPYTRTLYWSSADPGSASVSESSAKSAYVEAVRSVLDPNPMPPGIHQYSVIVSTPQREMKFTAPTKERHDIWLNALQYLLTRPSSVPVTSPANGTNTLHSPVSMDAELPEAEHQQRPDNFASPQSQRSVRTSRTGMSADSWNSTPRGQRSHSQLSQRGSMGKRSGTPAAEYLRWGGPDGPNSPTRSFEHIPGQEEGDLDFELHDDSMSDEGFEGLENVRACCDGRHTVGRSGKIEHHHHHHHHQTASQPEPSQTRDNHLDPNPHDIPRPVSPAWSFRSRAGSAHSHEGAGFFSRFGSRRSAKPISADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S496</accession>
    <name>A0A2R6S496_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="9"/>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S496"/>
    <dbReference type="STRING" id="98765.A0A2R6S496"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="11">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="11">
        <location>
            <begin position="172"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="12">
        <location>
            <begin position="361"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="565" mass="63491" checksum="07FD751647C99DBC" modified="2018-06-20" version="1">MDDDDDIFLSSSPFEPPAYDSRPTSEAAQAPAAGPMDVDPPPIPIPPYEEDISLSPEQQQVLNTVKEGKSVFFTGSAGTGKSMVLRKIITWCKETGPRYSFAVTASTGIAGVNVGGSTVHSWAGVGLAKEPAEQLVGRILGQDKYRRMLEKKLKRKEAGLPPDDEMEHEERDKQPRVVERWRSVRTLIIDEISMIDGKFFDKLEYIARALRGNDKPFGGIQLVLSGDFCQLPPVPDQNKGIQIAATFAFEADSWNRCVGKPIVLKKVFRQKEQDFVDMLNEMRIGRMELRTIRAFSELSRPVEYADGLEPSELFPTRNEVDVANRNRLNQIRSRAHQYNAIDTPGYDDYGRQIPPERVDRLLERLVAPKNIVLKKGAMVMLIKNLEQGVLVNGSTGVVADFCTTREALNRGIKIGLVESKKEDSKPRPGARNSGNEQLRRLKEQLERGVKKEEKVSKELVESSTPYPIVNFERATVLCVPTQFEVNSAEGGIEAMRGQVPLILAWALSIHKSQGQTLERVRVDLGRTFEKGQAHPRVMKWMGETIRDYKLVENGDDCEEEYWDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4H0</accession>
    <name>A0A2R6S4H0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000079">
        <property type="protein sequence ID" value="PSS37190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4H0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7550" checksum="F706982C4FE09EC3" modified="2018-06-20" version="1">MGLNARPSSPRVVKDASMEYLLCATRPSRFWDKNNRQSPDEKVDRVVVAVRYLAHDTGNERAPEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5R3</accession>
    <name>A0A2R6S5R3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5R3"/>
    <dbReference type="STRING" id="98765.A0A2R6S5R3"/>
    <dbReference type="OrthoDB" id="3253083at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="366" mass="40174" checksum="D2A9EAB1E4937EE8" modified="2018-06-20" version="1">MSTSPAPTVTRGEITLQPSYFTSSLFVSPLKQDIEHLLHLFAQYYDGTRPFELFKTLWSDQGWPLFHLKVFDARSREAFLNVTLRLFADYISNDTNPLARVAALFGVYTFFFSQPSTSAPSLHSIKHIPLPIDVYHTLLNLPSSLTEPHLLPLQPYATHVLTTLLSAQVFHILPHSSLRPHNPCNLPREYFVEDGVDVATALGLSAGEASSSTAPPLKLEKKKGRPARRDKVKKAKDAVNALDKWLEKNTYTHPSAGPSTEAKTTHTLISHPPAASLAIYKIQKAELLDVLNAGPEHDALVRANEAMLVRLRKIDEMAAEKGLEVGGEGGEMTGLTRVAKAVDELNEGNSRGGILDLVQGAGVTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5W7</accession>
    <name>A0A2R6S5W7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v467</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5W7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5W7"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="542"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSS37643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="830" mass="92157" checksum="F51E6651C056C0A0" modified="2018-06-20" version="1">MPKGTKPAPPQQANLQEMWGKNKSKVTKVEQEQPADLQEGPSEGSKRKQSPRAPDGVEPDKRPKAKRRRVVESDEEAPEPSTATKPPEPHTITTNGESSPKKKPKRISPTTRNEKSKGKQAMPPAEDDKEDSEMLSASSEEEDEAVASEGEEELGEEEAQQNAAAALQRTSEVDIAGGWKVGQPVPYAALAKVFALIEATTKRLEKTSLLTSFLLLVIRRRGEDDTTSLLQTVYLCINRLSPDYIGVELGIGESLLVKAIGESTGRSIAVVKADLKKEGDLGLVAQNSKNSQKTLFKPKALTVPFVFANLKEIALSTGHSSQNKKVSIITKLLAACQGEEAKYIIRSLEGKLRIGNAERTVLVALAHAIVLEEQERNNKRLNKEKLTARLEQATEIIKSVYSELPSYDLVIPALLEGGVDSLRDQCKLTPGVPLKPMLAKPTKAIGEVLDRFENKRFTCEYKYDGERAQVHKLEDGTVGVFSRNSEDMSKKYPDLMDQLPNCMKDTAKSFVIDAEAVAIDRTNGKLMPFQELSRRKRKDVKVEDIQVRVCLFAFDLLYLNGEPLLHKSFLDRRELLKEHFKIVPGEFDFAKSSDCDTVDEIQTFLEESVKDGCEGLMVKMLESEASFYEPSRRSVNWLKLKKDYLAGVGDSLDLVVVGGYYGKGKRTNVYGAFLLACYDADGEEYQTICKIGTGFSEEALQSHYDTLKPLELTKPRGDIKVGGAKPDIWFEPKVVWEVLTADLSLSPVYTAAQGLVEERGISLRFPRFIRIRDDKGADDATGPEQVNEVHSEFCCASLPFVKQIAEMYERQVLAQSKGGKKKGDGNDEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6B4</accession>
    <name>A0A2R6S6B4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000030">
        <property type="protein sequence ID" value="PSS37796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6B4"/>
    <dbReference type="STRING" id="98765.A0A2R6S6B4"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="21370" checksum="D7A481F8ABC0FA88" modified="2018-06-20" version="1">MSIVTIRNVEFLNNPARFLDPYHFRVTFECIAPLPDDLEWRLIYVSSPGNEELDQELDDCLVGPVPSGVNSFEFEGSAPLPSKIPPEDVLGVAALILTGSYKEQEFVRVGYYQNTEYDNEEMKESPPSDIRFERLVRDINTKPRVTRFQIKWDIFPQNGNGQAVSAGAATSAAVPSANDIDMEDPQPNGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE35</accession>
    <name>A0A2R6NE35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v13534</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001347">
        <property type="protein sequence ID" value="PSR70596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE35"/>
    <dbReference type="STRING" id="98765.A0A2R6NE35"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="14">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR70596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="171" mass="18434" checksum="8B3AB74D0A676156" modified="2018-06-20" version="1">MDPAKLAKLQAAAAANRIGGKGTVRRKIVRKTKPAAAQDDKKLQGALKKLNVQPIPGVEEVNMFREDGNVLHFSAPKVHAAVSANTFAVYGTGQVKELTELVPGILNQLGPDSLASLRKLAESYQAIQQNQQRPPNAADDDDDDVPDLVDNFDAVEDSKDDDEPPALEELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF26</accession>
    <name>A0A2R6NF26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v13178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001300">
        <property type="protein sequence ID" value="PSR70956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NF26"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="381"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="7">
        <location>
            <begin position="909"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="7">
        <location>
            <begin position="1146"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1023"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR70956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1452" mass="163579" checksum="265D476BF47848A9" modified="2018-06-20" version="1">MASETSGDVPPAPEIEPRGYQLELLAESIRRNIIIALDTGSGKTHVAILRMKHEVERGTKICWFLAPTVTLIDQQRDVIKAAIPVSVGLISGASEPDQWKNASLWKRVLAEHRIIVSTPQILLDALQHGYIDLGKDIGLLVFDEAHHAIAKHPYNEIMQLFYHPIRVQQGGNKNVSELPAILGLTASPIYGGDVEKAFQKIENNLDSTIRSSRLNRKELAKHVHRPSFKYVVYSAADAVGTVPSKNTAALLHVVDNMDIEDDPYVVAMRTQLAKMPPGSPRNRVDQRLSKTLVKKDTFTHKGLRDFARAATEICFELGPWAADWYVAKVLEQAKTIANQHAGVMASWQPPEKKYLLSIISQVNVAHPSGEPQAIMAGLSPKVEALLECLKDEERSFRTQEEAYSGIIFVTRRDSVLALGELLSRLPALTQHFQIGRLLGNSSTFKRHSFLDITRALLKETSTQTLQDFRIGDKNLLVSTAVAEEGLDIQACGSVIRFDPPPNMVAWVQSRGRARRQRSSFVLMLDENAMAQSKFVKWEQMEKDMMNQYNDTSRDDQEPESHEPEDGIQFPIESTGLRTFSVDCVYSTKTSARNHVAFFAYVALYDAGLLNDNLLPLTSVARPDEDGEVEVLLKEIEQRAGTANVPIQMDPWRDYQQVAEKWWYSQVTIEGLPALHMYTRCELPFLSEDEQPVLYIRDRGAVTVSICSASVEVDDEGAIAAAQQYTRRMFAPLYEQRMDAAKLDFCYLFLPIEEGEEELVWRERRQWMQERIQRSESTRMETPERSNADAFGKRFAYPLNIASVRYIERINKPLRFIGWHDGPISSEEAEELQARYDGFADFELSFPLLIAQAMPRRVNFLAPRDKKPDRELPILFHPMYSLVDFVSADDVQFASLLPSLLRFTTIACIVRSMRQSLLSSSSLRDIPFSLLRTALTAPVSQEPTNYQRLETLGDTVLKYIVSVQLFSQYPLWHEGYLSKRKDHAVNNNCLAKEAIRLGLEKWIIRDQFAPRKWRPLYSSDPFVPAKGSRTKKENPQQSTNGEGEQIAEGDEQGMQGVDADGDALNNKSPTQQRPKKRAPRTQELSTKMLADVVESLIGAAFEHGGFDLAIECAKLFDMGLPSWEKIPARVEVAFSRVEPIEDLPPQSTLVEQMLGYTFSRKALLVEALTHASYTGNIQTSSYERLEFLGDSALDMIVTDYLYHAPGKNYAPGQMHIRKEALVNSHLLGFICVNTSMMLEATMPSWDAEAGIRINNDSQRIHLFQCLLHSSSRVLEDQNLTLARYEKSGAQIQAALETDTIYPWAALTSLQAPKFIGDMVESLLGAVYLDSHGNLDAVRNVLRTLGIISLMERIVADEVDVLHPVSRLGIWAIRPDNNLKLEIKMEKADDNISCIISIDGVEEFRDTQKFRGKTSYNEVRFTAAEGAIKKLKVIETEQPADVDEADWGDVPDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF76</accession>
    <name>A0A2R6NF76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001297">
        <property type="protein sequence ID" value="PSR71023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF76"/>
    <dbReference type="OrthoDB" id="2729743at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="300" mass="33505" checksum="80B532A753EDCBA4" modified="2018-06-20" version="1">MAKAITLPPELIDLIISFLVIPHKCRTSKVIPHKCRTSKPSQTTLYSCSLVCRQWRELARLHIFHTVALRFVHNEYGRITLEDFLIFLEATPHVPPCIRRLELDFFEGFIDESRQGILEKPPASIDLVLLHAVLSRLPRLHSLLLGSFNPFNATPGDWAPTPIHLRYIDCNALGDILLFLEMFGNVDELVMGINQNYGSVSQVAQRVAGLSHLRLRSLKLRASSCSPSHIASFTEGILLTPLLNTLDSLTLMNFNTEGSLAAARRLLRGVGPQLLGVCIYVSDQLASKQSLTCHQHAKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFA2</accession>
    <name>A0A2R6NFA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFA2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7158" checksum="1ED03EBB60CE2FF2" modified="2018-06-20" version="1">MANGLPRWLSHLTTSVNPLVHLFTWSTGQLPYSQEQARQSVCTEATVSAHLDPSKRQILAGKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFN8</accession>
    <name>A0A2R6NFN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001292">
        <property type="protein sequence ID" value="PSR71183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFN8"/>
    <dbReference type="STRING" id="98765.A0A2R6NFN8"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="17499" checksum="0D5333C81B1605FA" modified="2018-06-20" version="1">MDHGGHSMPTTPSPPVKRCAMNMLWNTQIENTCIVFRSWHISTTQAFVFSCLAIVALGVLYEWLREAQKVMDRKIAATLSAQGKGKGRGGPVSEDSPESEEETGLLTGLRVVKESEGVAIPPALRFSRAVLYGAQVFLSFFLMLVFMTYNVSLPTISFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFP5</accession>
    <name>A0A2R6NFP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001291">
        <property type="protein sequence ID" value="PSR71200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFP5"/>
    <dbReference type="OrthoDB" id="2800083at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="663" mass="74691" checksum="ABF33BAB79FFE46F" modified="2018-06-20" version="1">MSAANIPPELFQEILRFPVLAVFEPFHRNYVKVNKRELGAYSLVCKHWAKMCQPHLFEDVTLRSREDLEQLLSFLDSSVSAVSRYIWRIQLEQKGLSVPWIHLLSLWVFPKLRRSVVPVVLHLESPMGALSSASFRSIHFALPRTHPSFSSKINHMKLSHITFRSFSDLLHVVKEMPVLRKLEGFHLSWPTPPDTVQSLPSAAYLRDISLSGCANSWAALWLVLVRRKQIVQIPGFSPIHFDLAQERSVVCSLVRSITNKSDCWVRTHRFGQDGYMIAYNNLSCQSALGSFLNLIIAPGPLKPSEKGATSHVFAISLCFIDCKLTLDEALLLDWKNFDDDASRLLHLQKVTLGFGSHEDMLHFAENVVNPAMVQLKNAGKLRFAVRPKGRRRWFTADPETEKMEGLVDSFPSSETKAVEIMEINDPGCGECHRRNLNGSVKLMSSVAPEPQAGPDATECGKESIKTVKLMRAPVSQTTLSTFFGRRGPESVTPYDSQLVFEKQKNTIAISLPVERGAGNQQSKDLPADPDDILGETELNRARTIGDDVPVDSESTLQDLQQATKDYFLLLNIHRAQLPQRTYRNLYVTAKSWNGQLDICVELYRCHGSEDGDSIAFLEDLKHCRTAYFGVLNQCKGELPSKTYRDLYVAATTWGAEQDVYFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG06</accession>
    <name>A0A2R6NG06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG06"/>
    <dbReference type="STRING" id="98765.A0A2R6NG06"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="294"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="794" mass="87116" checksum="3992274329FF7487" modified="2018-06-20" version="1">MSSPEENNDSETALVDGGKPEKKRRLSVRLNAAENPKSPGTDKGSWLPECSNATSPSSSTEVPTKSQLPPFEFHALMPQDTDGVDLSDDEWTAKRSLEQSLRHLSLDKGIHQFLGKSSNLLFLQTALDMKEEFVGGKLTPPAGVKAPPLGTRPEFWIEHPWLAQTMEREYPFQAFPEPPLMTRLIDLYFTHCNPYMPILHRNIFEQGVREGLHLIDSGFGATVLLVCAIGARFSDDPLILLQGSTNPHSAGWKWFHEVQSVRKAIRLSPPRLYDLQIAMLVAMFLHGSSVPQASFGVIGDGIRLAQDIGAHRRKMYNTVSRVEGELLKRAFWVLVCMDRALSSGLGRSCCIQDEDFDLDGPIECDDEYWFHPDPALAFKQPAGKPSKIAFFTCLIRLNQIHACALRTIYAINKSKAILGTFVGPQWEQHIVTELDSALNKWIDSVPEHLRWDPNMENTMFLNQSALLYSTYYTLQITIHRPYIPSPRKPSPFTYPSLAICTNAARSCVHVLDVQYHRSAASTYQNMMALFSSGIVLLLNIWSGKRAGSSANLHKEMGDVHKVMIMLKALEPRWHTAGRVLDILCELATIGDLPLPQGSNLKRGRDSDGPEISTPTVLGNGPRFMAGTKRVQHHQASSSSSMSQISSPSSMVSSLTQSINPPHSSDPSPPLLSSTSPWPAYETSPAIAGPSQVGSLSHMNNTSSRDTSTDTPFGLGFILPSVAHDTMVSSNAESTGPATPQFPPAAHSGIDSPSTTPADNYWTGMSTGTYATSPFPDVVDSDTLAMWSSAPAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGF7</accession>
    <name>A0A2R6NGF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGF7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6592" checksum="5ECD9D1447A7685C" modified="2018-06-20" version="1">MEHARNRFIVGLQDQKALGGVTLIMTTVIDNSYAYKFLVPLEAQVHIYYRRGMFEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGJ6</accession>
    <name>A0A2R6NGJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v12619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02001276">
        <property type="protein sequence ID" value="PSR71507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGJ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NGJ6"/>
    <dbReference type="OrthoDB" id="3238224at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="45"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="259"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR71507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="845" mass="93064" checksum="38E765D1919FF297" modified="2018-06-20" version="1">MSFTAPQLAQARTKLSQDDISTLKKSMRAMVNWDSDPRPFQLAGSVAQLEGVDMIIQAPTGSGKTVVVAGPHAWAPCEHMVTLMAVPLIALGEEMAQTFQNDFGLKAIVIHSKNGALSFQVIKEILRGDYQVIIASPEMLQSHTFINRILRNTSFTRRIVSLVVDEGHCISHWGASFRKKYGSLGMVRAFLPRGTPVIALTATLTRRVRSDIHSKLYFPKSGSLFRNEGNDRPNVSIVVRACEHPLNSYSDLDFVVPISIKKGDDIPKTYLYVDNINEGSEIIDHLARLVMARLDYTSPSCPDTGVVRPFNATLSHEYRTEAMCQFRAGTIRILVCTDAAGMGCNIPDIKLVVQWKLPSTFSSFIQRAGRAARGRGTEGLAVLLVERSAYSINLCQGELRRNRIRTVAIDKSTDKVQLDRKAVTATTAAVKVYAKSHGIERGGTKKRDDNPTGNQPPLNLEAEDEGLLTFVQSTTCRRAVWAEAFDNKPSGALKAATKKVSIKKGIPNKTAQAELRSWRERIFARDCANSLLSPSAVLDNDTIVLLSSVGPLPEDKIEALLKSRWIWWDTYGQELVEFFGASLVPIFEDENNQDSGTSSGVRMVGGELQFKKLDAPSIPVVDTFAGFEAAVVFVYCKGVVSKDGWDVTIEERDTHGNLLDPEKPLIGPAGELVVHREPKRRGRPVRPKTKELPHTPLPSTPVLRLDVSTPYFSHSNITVSQQSVQYLPSTPVPHPRSTANYNYYHDTTSMSGAISTAPTPWASWPAASHSSLPRVSNSLPSPYPGSMIYGSSPTTIYSPTPYTTPVHNRGYLPYYPALDRPNRGATCSQQEEFETGGSHIDKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGS8</accession>
    <name>A0A2R6NGS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGS8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7372" checksum="1520500FDE089CE6" modified="2018-06-20" version="1">MAHRGLFGFEFVKAYNSAYIECNHENPEGKVDEKCPPATSSISGDDFPINGYGLNQLPPGRTINQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH92</accession>
    <name>A0A2R6NH92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH92"/>
    <dbReference type="STRING" id="98765.A0A2R6NH92"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="56"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="145"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="597" mass="66488" checksum="A6A24C0FCC2E644D" modified="2018-06-20" version="1">MASSAALTTTHLPVLRSQLEEWREKQSAISGFSTSLSDIADNSLNSKDARDTASKDVVVAFRTRPPLEHEAEEKFKAYETKDTPEQDRTEASSGPATTEGSCKVEFCPGITVASAEPGTFIAHVPGLKMISLALSSGTACILAYGQTGSGKTYTMEALEYRIARDLFVIAERIGKSFVDAERHADTAGQEAGHGASGANIFEFSVTFLELLGKRAVDLLEPVDGLVLDNQGNPIRKEIPIHEDKNGDVRPRLISHIFKSSEELQELITNALAHSLAGSERYEDSKGHDKQRMLESRDNNNSLMNLKECVRAKAKMANEEGFVHIPWRSNKLTMLLKPKGPAPYSPADPRTWNHEQTVTWFTKQFTQRTRARQLNSYNLRQTEAEKKGKKLNPYDPTAPITLPVAIEKLCPDGMTGKHFGRFYTTEFIQRCLEVGHVDGEITVDVLKNIAAEVIGVLYYLILTAKTKARNDIMKSRKTLALEVYGEFILFFHGSPKENSIDEWDFVGESPIESIPGTDVKLAYLIIDRPPYTTLREYTNEQFLVVSQTLGSAWYTARNLAVSNAREQGTDMQDAEVMAIVEMMEEFYKPSSDADERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHU2</accession>
    <name>A0A2R6NHU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHU2"/>
    <dbReference type="STRING" id="98765.A0A2R6NHU2"/>
    <dbReference type="OrthoDB" id="3364905at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="464" mass="50595" checksum="C5E700421E0B5EE5" modified="2018-06-20" version="1">MPSTYEGDEFAASGSRFLSLKSRKQPPNGINGRRSPSGSLRGSSLAQVLDDDATSARHSLAHELAVALMPEPSAGSKLLAEEFGIEYDEGAEGIDDTAAHTEGDPHPDTQDPIPDPFSGPDPDSEPTFAAADAPPDFDPAFDNVPPTPQRRSRLPEQDPMVTLAEDLESTEKFLSQLRRLDAGDQGGQPKLEKLASDVIRRIDDTVREREGQVRELLEYEREFRRIAGEIGGNDVLSQLDELDHLTKEPKRDDDTTRHEDDRINRPLDAIHEEPLSNSQTLGSGVDWEGDLDRDRGHLGDEEDEYEHQYSPSPAKTTFPSAPPPVSGPPTPATTIVQLAHFRTFTTSVASSLATISEQTQVNAAATTEAGRKIRALKNKLGGWRTEWDSAERSRAKIEKWEAGSIDIDGTVVVLPPLGTPPRSGRVRVDGRKIVDEHLAAFEIAIKEANTKTERIAAAMAAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIK6</accession>
    <name>A0A2R6NIK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIK6"/>
    <dbReference type="STRING" id="98765.A0A2R6NIK6"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="252" mass="26906" checksum="16C50B681D5809EB" modified="2018-06-20" version="1">MAAYATEAPLTTPLTYLSLFGLGALIMRSAGCTINDMADRDFDNPFLVSRFARVGGKPSLDLSLTSPSGLAFNWGALLGWSAVAGSANWEVVLPLYAGGICWTLVYDTIYAHQDKDDDVKVGVRSTALLFGDHTRTILSAFSASSISLFTYAGLMNGQGLPFCTGVGLAGVQLARILYKTDFNSRPSCWQGFKDCGRAGAFIWAGALADYGLLLGGVQLPTLWPITHGIILGNEAVILSALWSLDSFTLFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIX5</accession>
    <name>A0A2R6NIX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIX5"/>
    <dbReference type="STRING" id="98765.A0A2R6NIX5"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="853" mass="95923" checksum="F378902F664AB8C9" modified="2018-06-20" version="1">MSLKFYDNRNEDEHNELDKIFLGSTAGKYFRSSVIPPPAVILWQSLVISICSSKSYESVASQFFDDNQRELEQLLNTAWKKQQFKAIRSLEFLNPAPASKNILKPTVDQTTKNAWNAEYIGHDHETLLETLRTVNRSRAGQYSNILPIIQSSGMGKSRCVHETARFVFTLPLNTRPPHESDAYPPSDCDAYDFFLRPDAETVTEGYPVCCAFFKALFSSSIKLLESHLSSEFTTYEELALAWRELLQETRNEFYADVCLEAKRLLDEGEISRTSGVEIIMLACNEGSRLRDVIHTRIVGKPLTKDDLTIMLYLDEAQGLLSMALHDGTMYDAFAYVAAKFLGFGFVLVTLSTNSTLAEFPTTLPSYPLARRTLPHPFTEFGFDCYEGGQALFRPNEMSLKDVAEESFMVKFGRPLFWSRLENSEEVDRVPGNIVHFARTKLIGKSNILPPGVSLLERRHNGLLAAIGTRILFEFDTSREESRTREMQLVEGHMRIVYSIPVDRQYIRSGYPSEPILAEAAAHEMNSEERPIINILSSFIDNGLIYKGDRGGLVARLILTQAYDKAIQTSHPQPWKYSQGVTVAAFLTALISEKYIEDVLNCTSDDGKTPLKEAFKNAYIRFTHFVQNGKDNKIDTDVALAGIVRGMALQITRNESIIDVLIPITLGEDKLREEIMTGILIQVKDKAATEAVDINADELHFFPPDCEGPRPYITIVMQLGLQTASDIRHSHEHWSPSRVVTKESHRTPQSMGNSLHPRYHINIRGCSGAVYGVVNKEDAYAKVVAPHNIIADHPKKSPRNLAALRRLKPVWQRNKQCSEWIGVSALQREQAGGGDEVLPVQAEGDGCPTTRMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ12</accession>
    <name>A0A2R6NJ12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ12"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ12"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="273" mass="30673" checksum="D1B13CCD2223CD22" modified="2018-06-20" version="1">MRVWLQINCGSPPLNQTHRDIWAALVDATCPSKGFKEYTGFFSNNTEELTKLLSAAWETKQFRSVRSLVYLNPSKKILIHKASPEDETIKNAWDVEYVGDSHKVLLDTLRAMNRFARAKYSNILPVVQSSGMGKSRCVHEAARFVFTLPLNTRPTGESSGYPPSDSEVFTYFCDANRGTITEARAACCAFFKALFSSSIKFLESNLSTNFVTSQELALAWRGLLQDKRSEHYADVCLVSRSLYLPRGLINANIHGSRKPSASWRKVKFPGSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJC9</accession>
    <name>A0A2R6NJC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJC9"/>
    <dbReference type="STRING" id="98765.A0A2R6NJC9"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000166">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="130"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="446" mass="49560" checksum="414B9DF18738D4A3" modified="2018-06-20" version="1">MALTASGGEVNDKPLLQVLPDGFYTPRLSVMANNRTHDGIRSVFHLEQRPGVISLLAGKPHSSTFPITSLNFTVRDPANPQSEIPIELSQEELEVGLQYSPTVGLPALVDWAYGLQEIMHGRKVGEGWKISIGNGSQDLIYKAITALVNPGDPVFVEAPVYAGVIPMFQTLQCEIIELETDSQGICPESIFSALENWPISKPKPKVLYTVPYGCNPTGTTATLERRLAVLELARRYDFLILEDDPYHFLYYGTSPRPPSYFSLERGLPEAGRVIRFDSLSKILSSGFRLGFVSGPQAIVRAMDDHSTVANLQPNSLAQVIALSIFSRWGYKGFSEHTERVSEFYRKKRDVFQAAMERHLAGIAEWTVPEAGMFMWFRLVVDAGENDSDSVIRTTALERGVLALPGTVFYPNGRKSAYVRASFSQLDEKQVDEALKRLREALLDGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJJ5</accession>
    <name>A0A2R6NJJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001156">
        <property type="protein sequence ID" value="PSR72539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJJ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NJJ5"/>
    <dbReference type="OrthoDB" id="2752927at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015363123" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="7367" checksum="B8FEE36FBD8F3145" modified="2018-06-20" version="1">MKHVLRFCKNQLMHAVWLLLLDDKFMEAYEHGIRVNCADGIIQQLFPRFFTYSADYPERFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK28</accession>
    <name>A0A2R6NK28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001143">
        <property type="protein sequence ID" value="PSR72661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK28"/>
    <dbReference type="OrthoDB" id="3215907at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="269" mass="29406" checksum="AE9653DCF256D475" modified="2018-06-20" version="1">MDVTQIFYAPPLTSNTLESYQRARLVRSTRKLGAVLGTTPRLVEPEPIPIKLLPIGRSSTSSLSSNGHNSPYGYHHGYPRSYTSVKASPSINSVYSSSSSNSSVVSLTLPPTYSSDVLPTPKSFSSKPRRSANTPHPLVLRVNTVPVKPSDIRVPMSPFTASIVPIVPGCTEPDTPVVPSAAEVRRKRMAKLTRTLGENIPPEIVFPPTTSTSNARSAPTQRQLATAVHPIKRSSRVWMTGSNLGTWTGEWNRKDIKEVQKKLRTLKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM55</accession>
    <name>A0A2R6NM55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v11030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001106">
        <property type="protein sequence ID" value="PSR73102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM55"/>
    <dbReference type="STRING" id="98765.A0A2R6NM55"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="299" mass="31997" checksum="26557D6ADA1A2A60" modified="2018-06-20" version="1">MAEPDKQAFRKALASSKNIIILSGAGASVASGISTFRGSTAGSNVVLSYHTPEAFKETPGAVWFYHERMRQSCLQAKPNDAHKAITALCFPSVLSRIAPAATSPALHVTQNVDSLSSRLLQALPPGEAPPPDTTLLEMHGSIFATRCTSCNHVQRSYSPVLSSALSSLKEGEDNIPVTALPRCGGDAWNGSNRYGRCGGLLRPEVVWFGEIPPLMGEIARKMNWCDLLIIVGTSFSVQPAAGFASQVKKRGGAVAVFNLERSVGDEVADFIFLGKCEETLPDVLDVKRDIELIWPESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM56</accession>
    <name>A0A2R6NM56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM56"/>
    <dbReference type="STRING" id="98765.A0A2R6NM56"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55944" checksum="D416CEBD0B5E971C" modified="2018-06-20" version="1">MPRFWVLLSAGPYDGRYAWQNHPTGQPIREAKGLYVYDPKALGNIIVKDQMIYEEPSWFISWNLMTMGAGLLSTLGDHHRKQRKMLNPVFSIAHMRHMTPLFYETTHRLRRAVTTQVAGGSSEVDILNWMSRTALELVGQGGLGYSFDLLEKDIPNPFGDALKRYLPLNFALQLWRMFSPYFTKCGPPGLRRFVAKFLPYSKMQQLREIVDTLDYQSRKVYNQKKVALEKGDAAVVQQIGEGKDIISILMQANMDASDEDRLPEDELIAQMSTLVFAATDTTSNALARTFHLLAEHPDVQEKIRAELLAVGGNDDIPYDQLVDLPYLDAVCRETLRLHPPVSFLSRETRADVVMPLSQPIHCVDGSIMNEIPVPKDTTVIIGIRGCNRNKAIWGEDALEWKPERWLSPLPKSVPDARVPGVYSNLMTFLGGGRACIGFKFSQLEMKVVLAVLLRSFRVTLSDKEIVWNLAGVNYPTVGREASRPSMPLKLEPINLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMS2</accession>
    <name>A0A2R6NMS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMS2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMS2"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="554" mass="62017" checksum="B69876353B187086" modified="2018-06-20" version="1">MSADDKLKIVASSALRSLFCSGKIDIPISSFDLLARVISSGPPAAGLLPGSEPAPRFRLTDLSIFDRILESISQEWDFGKITISHEEQSSGGGLTVLDVRLGQSFAHKTEEYAGFHGTKRKRIVDEDADSAAGDAEDEEDLNEDTSAGWKPAPSTLDRLSKEMKVVYSLLQRGTARGRLLAEQFHSPNPSFEPICSHITKEDCLKARRLDSDDQSATICDCVHFRALIRPHTDPTLGHCSYLNTCYSEPTYALSPSIPPLPSNRAPHGYGAQGQSAVTLPSGLGAGGRGKEKAPCRYLHFEIDWDGSDGSRYRDKRSDVRKKPFKLGIGQGPNGKYTQMLPPQWINCDLRRFDYSVLGKFQVIMADPPWDIHMSLPYGTMTDDEMRAMPIPMLQDEGLLFLWVTGRAMEVGRECLRVWGYTRVDEVVWVKTNQLQRVIRTGRTGHWLNHTKEHMLVGVKTVTDENGHLKFPSWANRGLDTDVIVSEVRETSRKPDEVYGLIERMCPGGRKIEIFGRKHNTRPGWLTLGNQLGADQIYEEDLAARIKARFVYWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNB4</accession>
    <name>A0A2R6NNB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NNB4"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="1196"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1632"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1664"/>
            <end position="1684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1715" mass="187155" checksum="B307D6ED3CD97212" modified="2018-06-20" version="1">MESTSIAEQRATAVAKLKRAASLPRMKDGRRPPMHVEAVSEGERGEKQEDESAQGSEGKPETPDELEVAEQSEKVELVLESHVEENEIEKIGQDIDLVEEKVEEDITQEDPAERPTTPGRKRRSRSRARSRGSKDLRNKAKTPPPVNNESSADEYGLEDIPPSPPVVSPIPSHFAAFQASRLLRSPISPVSPMFYPGTTPSTPMLPSLDEIQKGIGLFRSNSVGAARMMAMQKLTGGSEPLDPTFGSPSPTPLGRNNTVSGGERIAARRNLLRRLGERVKEADTDVTSGGEEVSRPATPATSKRRRRRSRASAVLDDRDEREQPATSPTTPVVPPSPLPPAGYNISGSPFALTVEHRRTPVQHIQPFEEIMGGRGVVIEDEDEDGDRQLPANGNAGLPITPARRLAQRVPHTSDAPSTISTDSTHAGVPVPVFMSSQPAPYKADAFPASPFATPLREKPFADEDEESDAYRELRLRVPTRNAFERDSEISWVADPVPMSRMPIHDDDDEEEEEEEEEAVEDAKLEPDLESSGEHVQLENLPEHEEQGKTLAEPSDRRSSHSSYAASLHSPTAKDLVIEIETSPEMSPAQMPPSPISPIAMSPHTINDHTADPPPSPPTYPMRLSVATPMQHFDRSPSTSDFPDWDENRNESTPKRNGDTSTWGRFKGAFTRSNSSSGRRSRTNSLSTRERRNNTDSSVSRESGASQTSAKVEKGEVQSVVTQQQSQASFLQSPSASASILSLAPQGIPPGGASPIPPASPADLLRYGDSNSKLFPFPGIKHLEEQRNKAKGLLPSASSPDIVFAPQSIEAIASSSSSSSATTKSPQVSRERKLSHQVSDSRLLAKFAPPGSAPPISSTPSTGSHPDYFSLPSSISPTTSQAGSMKLPMNREGVKKWLSAKKLFSSQSSVPSTPSTPISPPPNSSRPSTAQKKPSLSDLRLLVGRNKDNDLSSDWEDIGSDKSRTPTSALSAASQSLLSKHLKEEPNPLDGRVKNVEPVHQNHNGHATQSPSAVQELDVRKNGISSFVSFPSPPEPSSSTTPDPQSSLDEFTTRSTSVSLSSGVSSSPESPEIKTNDSTRAAIMLERLEEALGRGSKSSIWPIAIDDPPRKLILCSPVLQVANANTVKDRILFLFNDILVIAKPVVQEQDVLLDSMKPTPLDRKVIVKSVVLLRELKFNADRDESRTKAAACVSPTRHPVIRNFVYQFAKDADSAITNLFDKSNSRDDPVALGQLMFRTTDLDRVRLGEYLSRRTSKVVLKVYVDSFGFTGLRMDKALRAFLLSICIPAKASLDYLLDAFAGRWYEANAGIVTYDKDLAIRLARAIVQLNEVMHGGIAQMPGITGYPRRNVISRDFADAFRRFDPRCHVSNDLLDKIYAAVRRERLSQARNPSSDPVSNSVPTIQTISIKRPLPSRLTYRVQSDPIVLRIPSSDPHISIQLFGQDLIFDPPVLNFAKTSEASFRVTGTSLGPKTIIMWRSGANALSYSGLPLSSSVVVERAFMRNTFQLAFVNHHGAKRKYMFSVDDPLIRHEWTVSLKRHIELASASAPNSSLIEPSGSSSKIHEAVNAMAFKALQSALINSDDDLHPGIFPSAVDQALARLTGESPGRPILDGPLEDNRRRSRLDGANGHGRSKSRSQVYHRHGAGKSEPHFEDDTDASGDDGLLRRDLSSSQRSDDHIWSSRDLEIVCRQNSSLASVLAYLRVEEHGGTPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNK7</accession>
    <name>A0A2R6NNK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001037">
        <property type="protein sequence ID" value="PSR73990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNK7"/>
    <dbReference type="STRING" id="98765.A0A2R6NNK7"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="17706" checksum="752E64242F632C78" modified="2018-06-20" version="1">MARFRAYSTDSEDDSVLSSNEVGQEDGDASEVASSLHESPQRRRSHFSAQDSDESGMSEDEEDELEIRERMVSPPLASTKGADPSITPWAREVGVDPQKMHVMQASLFRVPEEEAAMKAAAQPISRRQLVLPSAVSRKHSRDSDGDGLRADSRQVLAIIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP07</accession>
    <name>A0A2R6NP07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1264-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP07"/>
    <dbReference type="STRING" id="98765.A0A2R6NP07"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26192" checksum="F5C4E050DE241224" modified="2018-06-20" version="1">MDSDTKRAAYHTSAYQASGSAMMSFEPINRIHQHICAFHAYSTDHTRHVEAHHFCTHYTPDFHQCVIYDSGAADARLIGIEYIVSEKIFEGLPPDEKKYWHSHKYEVESGLLQLQVKGAIPTAATDVAEQPAMLELQRTYGKTIHTWAYDIHPDLPLGPPNLMLSYTSDENAPPADLVKARDEKWGMDTAGKRKLRAGYLPPYEKRPESDMWQDTGECISFEPQERNVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP59</accession>
    <name>A0A2R6NP59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="9">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v10330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="9"/>
    <dbReference type="EMBL" id="MLYV02001056">
        <property type="protein sequence ID" value="PSR73848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP59"/>
    <dbReference type="STRING" id="98765.A0A2R6NP59"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015350394" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="11">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="188" mass="20173" checksum="A7D14A10DE519307" modified="2018-06-20" version="1">MYGITPLVLLYSLCVVYAAKLAALPEACPRLPNKLPAPTDLPIIDDLPNPFRFFNNVSLKSTADWACRKAELKILVQEYMYGYYPDHSRETVRTVRTNGTLVITVSVGGKSGSFNATLELPTSIDATPRRPVPVVISAGGQNDTVFLGSGVALVTFNVGDVAADSTTPGGAFWDLYSGEDIGGLLEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPB9</accession>
    <name>A0A2R6NPB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000995">
        <property type="protein sequence ID" value="PSR74340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPB9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10127" checksum="915DE1630C809A90" modified="2018-06-20" version="1" fragment="single">MPLAITIACEEEGSPLFIIPFAKMLQPARLGEHLPSPLVLPSPVTCQDEGNLRGWGSFSLHRMSFLRSLDPHEAGGSSPFTVALVVLVKTNDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPN9</accession>
    <name>A0A2R6NPN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000985">
        <property type="protein sequence ID" value="PSR74468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPN9"/>
    <dbReference type="STRING" id="98765.A0A2R6NPN9"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="14834" checksum="C831AF16BE1E42B3" modified="2018-06-20" version="1">MLVTGGSDGRVITFSLPFNFASSSPPPPSQEPSTPPKVFPVIQRLSAHDSSVTGLQLDSRFLVTGGNDGRVRLFELTPDIVANKGERCEYVREMCEPSEGVWKVACTRETCVVMSKKVDKTWVEIWTFKPQEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQA2</accession>
    <name>A0A2R6NQA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQA2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="7778" checksum="1A170EE8B325D0E2" modified="2018-06-20" version="1">MGGDAEADDAEVHDADSVDNADSEVNDAELDDTDSEMDDTESGSYAHGTDSDVDGTDSEVDDTDSEVDIFEADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQD2</accession>
    <name>A0A2R6NQD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000962">
        <property type="protein sequence ID" value="PSR74705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQD2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13952" checksum="8B360750D9CF9CC1" modified="2018-06-20" version="1">METERAVTRVSLVVRGERSDVGVTLVGVMIVGVGVMVVTTVRVWVVVNVLVRKFTAEEPKVTAVKEPLKKIGLVLDSMEVVRKVVVSMKEEIKTSESTGGKLEDDMESKTSLRTWEVGSERVFDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQF5</accession>
    <name>A0A2R6NQF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000957">
        <property type="protein sequence ID" value="PSR74766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQF5"/>
    <dbReference type="STRING" id="98765.A0A2R6NQF5"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="694" mass="79125" checksum="1FE256CB9DD64637" modified="2018-06-20" version="1">MHSVNYLSLVPNTVLENIAFWCIDPLGPPAALIPLLLICKDIYLKLLPPGLSHASGERPDQYFYARIFKFLFDSGAIDRRLGPRPAYSRNLAAQLLVYCPALKRIRSGNIHADTVQDDLWSAYFMMMENDGRNAAQLLEWAGLKAFVDRFVRTRLLDGATNGWPCENIINSLAVWLLYATTDEATIISETPEKRGELMDLLRPYVTMPIRYPSFYAPDNHFEFPISRDFLERLPVTIRTPNGAYPVYRSPLDSLARPMHYREPFYVRAPLISVSAKLLYFSRAEAVPQEVVEGTPLDRADAIARGITYILPTRVDYAEFNSHKAVKFLNNGSWERNQPISMHLDIDWDRSLYCFDPWSDGPLNLPYTFGTLTGLWLGRINFPDMRYFSRVMSRDYDALQQPMTYLPLAMYLREHHSINPRQRIPPGGDPKKEMDDGVNNGWLPHGKMRLDRRGLSLYDQQADVMYQCEHYVRGRPSSHNVDTCTNCIAKREREEARYAAQQEDVDAMDTDDDSEGVEYSERSQRSRRLGGTFPDDESFDGEMQRGENIRMQINAGLPDDTDIDEVLDAEMASTEDSSEYLSDDGSVSDESDDGEEVECNGVQDVIITGETLPRHGDAWHHFVFYGRVRKFDGLIALVRRPISEPTRGVQIFRGYVIGGKTWIGNWRALTADINSLPLEGPFVASRFETPARTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR29</accession>
    <name>A0A2R6NR29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000937">
        <property type="protein sequence ID" value="PSR75061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR29"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="11112" checksum="25B9C579F5C3E816" modified="2018-06-20" version="1">MDLNSIDNGMDSEDSDGSNILEAVYDERDPWGYYDEGNFRGVVVNELDIENELAVYNISLPSHTHDSFANNLKRIRDAKWITKKYGKQMEQFYGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR77</accession>
    <name>A0A2R6NR77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000922">
        <property type="protein sequence ID" value="PSR75161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR77"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8627" checksum="B4144C0EFFB1AC1E" modified="2018-06-20" version="1">MQNAADPVTRYGETTLRTLQPLKFKQSIRSMFSRGTSTLVDEMPEEHEMDVIDIRSRQERFDITTTALSPVPEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRG7</accession>
    <name>A0A2R6NRG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRG7"/>
    <dbReference type="STRING" id="98765.A0A2R6NRG7"/>
    <dbReference type="OrthoDB" id="417125at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="14807" checksum="723C5F6BB0B68F55" modified="2018-06-20" version="1">MKLSHPERIQTAQLLFLLDVLSKDLRTFKPRTIHANRGTFYAIAQGVGLGTQSARQAEYLCDLEALWYEITFGGENGRGRFLTKNDMDFVVNEEILTSEYAGRLIELGMDGWIVQGDALYRWLARKGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS47</accession>
    <name>A0A2R6NS47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS47"/>
    <dbReference type="STRING" id="98765.A0A2R6NS47"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="206"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="344" mass="40095" checksum="970DC42553C56B4E" modified="2018-06-20" version="1">MSDSEGDFSDELLELAGATEKKRRKRQAQSKSKRRKPEVTRSSDSDSDNDQPESEEETNPYPLEGKYIDEADRNRLMQKSEIDREDILAQRLEEMQRIQDKRNLDQMLRERTGGDETVSKAAKRQHAQRGATKEKSRKLDELKAKRKAKDEKKRTRTDSPKRERSSSPMDMETSDEDEEDGQISKFEEQEEKERRLFSKISPEDDTLVLEDLNKVRLTRDMIAKHCMAPWFEDFVKGSFVRYLIGAEEGTPIYRICEVTNLGADVVKAYKVNSQMVNQQLELKHGASEKTFYMDKVSNSTFTEREFHRLVKVCEYEKVKLPSKRQLEKKAAQMTKFATQPMTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSG0</accession>
    <name>A0A2R6NSG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Promethin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSG0"/>
    <dbReference type="STRING" id="98765.A0A2R6NSG0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="23788" checksum="7FC8F5B4941E09F0" modified="2018-06-20" version="1">MGATYNSAEDLQSYFEKSAAIVRRVVDRAEIAYVRPGIKNVAESFEKRPLLSSFVAVFVFLSFLPVISFVGFSLFVIGTFTFLGLAGAFAASTVVVLVSGLVLACTLAFLLLIAFFLSSALLVGFLTTRLLLLVRTDGPRTGVTEWTKETKTRLYRGDIDSPSHGPSNGPSNETEEYVNSGGKSDDEVQSEGSVGSTVIVDGVDANAAPEKGQSVVSLKSEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSG8</accession>
    <name>A0A2R6NSG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NSG8"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06629">
        <property type="entry name" value="STKc_Bck1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1103"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="727"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR75870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1382" mass="151980" checksum="13FA5D731334392E" modified="2018-06-20" version="1">MSDEAKSMISKPKKTRLRILVVNNPGPESDDENHGPHPISSNPSEKQLPPATQYAPPYGPDLVKCPSEYSNPSNPTLSSPSSTSSPACESTPPPSTPGQSNPTLDFAGDGTLRQEPVLVPYPDSNETSPQALHTYNPTGLFPGMISHPRHGRRLSANRPATSPTTSIPESQPPQNGAGRPSPSERILLVTTDAEHLVVVDITGARDAAYIRERIFAKLQISDDDQPRFSIYRTEIGKFAIGDALSDEQLWDLYCERGDERGSIKLLVSHSHAPVHEASHNSGQASPVNTIPPPVLPRHGLYPPLHPVRPSKSRRGSFSSASERQPPDVDYEASGSEDPDPPDREPRRGVRSPHQFPGPRHAYIPGFGRPQSPVGTLDRTRAQVFPEGSGRTRGGVLPTPPSQHNSPELIRPRDPPLAPVPPHWHSRSPSDVATERERIIQVSDNQSDLPQPKRTFKEREEREEKLKRRDQVKKERPTRPPHHDIREGWTVVPVDVPDSGYKRDRPTTPQDSRPSPRHGPTSVFQLPQQPRGPPPPPPIVGPNEPRNRKRQGQPVPNSFVITWKGPDAPGKPEPAPAPAPRSTPGPSWPRIFGAKSMHDLRGSYVMQAPAGGSGGRSRPPASPLPVSTRPGTGTSNSSVPLNGTMPNGNGNMDPPSSYSEASSMSEMGFPKSYEGPRGTLASPIRPSPVYHQPAGPMFLGSASSNLCHLPQSSTGSDLANLTNRINRSLQSPHHTEKPRMVSPPYSGSVRTSLPVREDIPGPTMSFGPRPLPSHPRYDRPLADPPVLDHTAAPRIPSRSPINGKSPVFETNQTDQRMEVLPVQRTLSSLPVREDDNDALSSSENTVRRDDYSRWQFPLQKNDGPGSSTAIPPPRAPSVDYQPDSDEESDGGTLWAKPPPKASRPVLTPIDTDSSPSSRHSPLPQENPRVPPPNFPAPPGYIPEPPPPPRRTVRPNNSGSGKNLQDQRTSRFDNNFDYTWAPRPPPEEVFESLQEYFPEHDVDEPVIDASSGGASPTSAEPDPLPQTDRKFKHKKSIRVVAAEHKRRIDRTSRMEANVNNHTILRKRNTKLWGSRLEEVTTAHAQQDASTSAESSPGTAKPIFRWVRGELIGKGTYGKVYLALNATTGEMIAVKQVEIPRTASDKDDSRQVSVVEALKLESETLKDLDHPHIVQYLGFEETPTFLSIFLEYVPGGSIASCLRKHGKFDEEVTKSFTGQILSGLEYLHSKGILHRDMKADNILVETSGICKISDFGISKRTDDINMAGAYTSMQGTVFWMAPEVIDANKQGYNSKIDIWSVGCVVFEMWTGQRPWSGKEAMAVLLQLYQTKQGPPVPQDVVLSPLADDFRQKCFAMNPDERPTASELRKHPYLELQPDWTFFGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT37</accession>
    <name>A0A2R6NT37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT37"/>
    <dbReference type="STRING" id="98765.A0A2R6NT37"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="586" mass="63286" checksum="26F1B2BC69A0AD27" modified="2018-06-20" version="1">MQRSPTTPSGAQESRQTDTSDPFSADRTQGMFERSQTPSSPAAANGNGHSNQVTSVPTTPDTQYATYTVPPLLDSERPSGARLPSYATVGNPNEKVAVNALNPDGTSAPITMKPWVPVPLRPWFWIPLVCLMAGGGIAFEVALHFSKKEQGWSTKGDFSTEQGLMHYVYTLPPVAISMIFAGVWAWTDIEIRRLQPYVDLAQGNSPPQRSLLLDYTRDHTFYVWTVAARNRHWLVSLGSLLVMLTFSFQPLAAALFNVQDIFQTDPQQIVGNLGAIGLNQNGNFEDLTSFLTAAGYASANVLYGIGDPSFIHNGFTVAPFEIPNIGNGTVLANTTAVLSEPHCVAPDQAVSMVQLADGWNNSATFNDCTFSWNVSKASQNLFGVNPVPDSTSCASLTAIPEQFRPIIFWFFTYIPAPMASVSLCTPSITLWDASVTVDIASNNLTSVVPIGPLGSHNGTAPALAQFAGNVTGDPLDGRAYNGLFFNLNDSADPFTLGRQTAIQLALPAAVFQAAEIFGLTEAFQQNMFANLSVDVYVSWSLPFFCFAGENRLIDQLAADNVFGPCSQDGVFFGYGTAPHHRDDDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU52</accession>
    <name>A0A2R6NU52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v8300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU52"/>
    <dbReference type="STRING" id="98765.A0A2R6NU52"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR76703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="218" mass="25235" checksum="6709A29C612ADB52" modified="2018-06-20" version="1">MLNRVGSKFGGGGVAGASETNVDRRERLRKLALETIDLAKDPYILRNHLGSLECRLCLTLHTNEGSYLAHTQGKKHQTNLARRAARDLKETQLMIAPTQSNIQRKVFLKIGRPGYRVTKVRDRDTGKEGMMVQVHLPQIKAGVIPRRRFMSAWEQKREPPNKAYQYLIVAAEPYETIAFRIPAREIEDEADDAGYWNWSHWDPDTKQYSFQFMFRLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV89</accession>
    <name>A0A2R6NV89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV89"/>
    <dbReference type="STRING" id="98765.A0A2R6NV89"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR77443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="141" mass="15211" checksum="A651CD24775C2223" modified="2018-06-20" version="1">MDNAEFHAAVYHVVRQIPPQNVTSYGHIAKLIGMPRHSRHVGQALKWLSPETAPPIPWQRVLASNGTISSRGPGTNGAQRQREALEAEGVEVTQGRSGELHVNLHRFGWFPAVGSIDTGVVHNDSEGQTSNSDDDTGSGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVR2</accession>
    <name>A0A2R6NVR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000778">
        <property type="protein sequence ID" value="PSR77759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVR2"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43625" checksum="D8D7D3559E588248" modified="2018-06-20" version="1">MTPYNWNQISISSYQMNAWNFPQSVLAGTMAKVYVEWDQYIFDDQEDDGGEVVYQLQGAPISASFQLQARATTTSFNLQAYYTNVATTSHSLGSIPPIGCSSVSLRADHVLTQTLSVGGQLANGARYFDLRPVISSGIFKTGHYSTLPIIGYQGANGESFSQIISEINAFTAANAELIILNLSHDLNTDSGYGSLTQANWNQLFQQLSGLSHLYVAPNPTTIDLSTLPLSQFIGLGSAAVIVLVDAGDKTVTLGSYASQGFYNSITQFPLFNSYADSNDLSTLENDQLTKLAQNRTSWNSSEFLLSWTLTQQGIDFTQKDAPSIIDYGNQANNDLFTALPPVINRNVFPNILYIDNFNRTDVTALAIGINDYNTNWQVTGTQVQRFASLGRRVSQLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW30</accession>
    <name>A0A2R6NW30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v7652</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000768">
        <property type="protein sequence ID" value="PSR77910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW30"/>
    <dbReference type="STRING" id="98765.A0A2R6NW30"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR77910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17966" checksum="BD368F9955E0B212" modified="2018-06-20" version="1">MTLYPDVMRRAQGEIDNVVGRDRKPTFEDEDHLPYITAIVKEVLRWRPVAPLDALVFENIWAINHDSTYFPEPDEFRPERYLDSNGVLAEPLHDTHHHGHLSFGSGRRICIGQYFASQSLFIAIATILWAVNIEQALDSDGRPIIPSRTDTVDDGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW83</accession>
    <name>A0A2R6NW83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000756">
        <property type="protein sequence ID" value="PSR78150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW83"/>
    <dbReference type="STRING" id="98765.A0A2R6NW83"/>
    <dbReference type="OrthoDB" id="2395160at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015323584" description="Polysaccharide lyase 14 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="2">
        <location>
            <begin position="92"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="346" mass="36621" checksum="18ADE8F997B32B1F" modified="2018-06-20" version="1">MRCVLALSVLLTQYQSAFAQIVPAATLASQLSLTTSTSFPFPTATLSNTDTQSFIVSGWSLSKGRIQNGASDLEFVQDPFPKSPAPGTSASPGPVLQVTYPAGSFSHDTGGAQLYSLWNTSDGSTFDSVILSYEVAFDQNFDWVKGGKLPGVRGGPDPDGCSGGNASTGANCFSSRLMWRTNGAGEVYAYVPETNALCASSDFMCNSDGFGTSIDRGGYSFLSGQWNLVTMLVRLNNPLDTANGQVSLYYNNVRAINEEAIQYRTSDAISVGGLYFSTFFGGDDSSWATPQTTHTYFRNIQMWGSSAASNLTGKVSAATSTHAGSALKWMVLVANSVVVVLIGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWC2</accession>
    <name>A0A2R6NWC2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWC2"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015218191" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR78206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="222" mass="24443" checksum="A9FB0954EFB79FE0" modified="2018-06-20" version="1">MLILHTLGALSFGALANAAKEPPSSSPKNYTGIPPGDYSTQWQQYFQVEDPLPDINFSLGNNYAGNILVQRPNHPNDSVFFWGFEKENGSLTAAAGEREIEPWAIWLQGGPGSSSLYGLLTENGPISLIPNLHQFTQTNYSWSNLVDYIWVDQPVGVGFATADSEGYAKDEDQVGIDFIGFLENLVKVFPSLANRPFYLTGESYAGRYIVSAFTMVFSLEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWF3</accession>
    <name>A0A2R6NWF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000752">
        <property type="protein sequence ID" value="PSR78248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWF3"/>
    <dbReference type="STRING" id="98765.A0A2R6NWF3"/>
    <dbReference type="OrthoDB" id="3047760at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="255" mass="28271" checksum="ADD3DBB32344CEFE" modified="2018-06-20" version="1">MAAQVARIPFAILSLNESFPHVDIITQLAEITAFDIHIDAGTDVTAEVMHKAKVIVKVLESLKGNPDISEEMIATAHDRVSALQQARITTMTPDQGAGFTAAQMQQLQGIVQPLRDEIHGLRDEMREDMRGLRDEMHEEMQSLKFRLDNNETAQRNKLLLESRPAALECRKKQVPGDGLNLCQQLGVAVGANPGNPLLGSKFRDEIDTGNLTAADISGMIRFYNETFGIVAGDQLYQRRIKVSNWLCNLPPSRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWG6</accession>
    <name>A0A2R6NWG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWG6"/>
    <dbReference type="STRING" id="98765.A0A2R6NWG6"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12659" checksum="615F89DB0B5FAC7A" modified="2018-06-20" version="1">MSGQSALILGATGATGKHLLKELISSSHFTKIGEYGRRVTPQSQIPATNKLEQKVVDFETINRTAFQNDRWDVIFITYVQCSVSHLFLRTKTEPIPKARDHSWKRRKCSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWU2</accession>
    <name>A0A2R6NWU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWU2"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="300" mass="33384" checksum="05F949FA7FF5F401" modified="2018-06-20" version="1">MQQPTLQNVRVRTTRDALLIFYAVARRVLPMIARRLDAEERRAIVPGNVYIWEERCANSEITGLGMERCQATLDGLNTIDAISGVGDVVVPQGWFRNARASKSKQGEAIRDEDSSIPFQDPWATGESFPGPYRSEFVVQGVAGPQEDQRQWPAAPPRIPAHSYYQGHDDYRSHGQPSQSVSSYPMRAPQLPDAHPDYYRDPSPFTQSSSSSSDVSSPRAFTSTPLTPVVAPLQSGPQASVHRSVASERNLVPLSFLTNLHKPARDPIAEDCLRRLSNTHLPIAHTPEPRWPEMRATPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWW1</accession>
    <name>A0A2R6NWW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWW1"/>
    <dbReference type="STRING" id="98765.A0A2R6NWW1"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="1">
        <location>
            <begin position="127"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="210" mass="23458" checksum="D302A06EA38C99CF" modified="2018-06-20" version="1">MSRTGIAAGSPIPIALMKRLVERMNLRELTIAYGMMQPHVKAKIVNAQGKVVPINTPGELHVAGYMLQKGYWNDEPQTRKVMQIDDQGTLWMHTGDEAIMDDEGYLRIVGRIKDIIIRGGENLFPVQIENVLTAHAAILEAAVVSVPDLRYGEVVGAWIVRDPHKPSVSREQIRKIVAEGMNPQVRYLPFNITLDQCNGCQANRAHLPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWZ1</accession>
    <name>A0A2R6NWZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000722">
        <property type="protein sequence ID" value="PSR78834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWZ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7552" checksum="D3FA3A434F72AA5A" modified="2018-06-20" version="1" fragment="single">MGEMLVAESPGPFTVGTPTIKPKAPVFGLFITMSFNFVHSTWVRWRMRAGRSIVNELGTTKTQLAQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXF3</accession>
    <name>A0A2R6NXF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000706">
        <property type="protein sequence ID" value="PSR79203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXF3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6381" checksum="F02515D39C1DE618" modified="2018-06-20" version="1">MRCETETEDRWGSAPEGISEPPAKERETRGRCATLPWAHVVATIEPWRMQTASVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXH5</accession>
    <name>A0A2R6NXH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXH5"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="33455" checksum="15257119E088B794" modified="2018-06-20" version="1">MYGVNICENTSSGKRHTRAPKGSSPKSPAEVAAGKLYAKEHGVLRGGVSKADGVPTGAQPVLNLEAEDEGLLVFVQSTSCRRRVWAIAFENNPQDLQQRPSGVLCCDICDATLFDRTRPGPPIRNSKISAPQKGDLDLDAKQKLEFWRRDVLQRNNPSSMLPSSAILDDTTIRLIACTGRISSEKFKQFMKHQWIWWDIYGEELATYRESLFQHLEPLPEKAQKPKRVQKQKVAGYMDEGSSVGGAGPSTGLLHFESLKVLAPGPLDNQPYEHAVMFEHYSQQPASDSRRGHKRKLMASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXS4</accession>
    <name>A0A2R6NXS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXS4"/>
    <dbReference type="OrthoDB" id="3630793at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014988">
        <property type="entry name" value="Uncharacterised_YqcI/YcgG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40045">
        <property type="entry name" value="YCGG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40045:SF1">
        <property type="entry name" value="YQCI_YCGG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08892">
        <property type="entry name" value="YqcI_YcgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015326537" evidence="1">
        <location>
            <begin position="27"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="33904" checksum="DE44D2BDBE64B1FB" modified="2018-06-20" version="1">MLLLALLALLAATGVFLVFKHPTVVAFCSRLARLWTSENSIFDVKSLAQGVHNISSTPITFTKEEIIRTFAAESWQLQAYNDYASVLLDTERVFPCIYAAKGFKSNEQVFVFLDSDDIGDPRHARTVASALMQYLPRARALGPNTSLVVLTKHTNDTRTVEEYNVLFWKLLDGLARLDEVAWPANVPKDIDTERWCFSFNGESVFAAVQTPAHQQRLSRYADSLTVAFQPKWVFDILFSTDAKRESAKTKVRRLLSKYDVIPVSPLLSNYGDDGTREAQQYFLMDENIPAPCPLQRLAADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY14</accession>
    <name>A0A2R6NY14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY14"/>
    <dbReference type="OrthoDB" id="3365874at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37228" checksum="836013E1B5E4C4D6" modified="2018-06-20" version="1">MTRGRRKDLTIPPSRALLQQRDYRARKAQYVADLEDRCRRAEEDNEKLRKELDSMRLKMAAGGTMAPSSEVVAASSELMHQLTSAASTLARFQQLAFNEQAQAQAHAQAHALAQAQMQTQNLRPPDSPPSLRAHEAHTLPPPSKSYPKLPPPQLLIQPQRPSPPRQVLHPSRHQAQPEYHHHRHSLTPPTLPPPLPGPSSRHEHPLIHPSQSEPTRTTPSSPSSSRSRGPLSAGDRSVQYVYNEVECCWGYFDCRDLGSDDREDEEDELIDDDRSVASSHKHRNHYQRSNGARNGHGQSVHRTSEMRSTSSSPGLDDAPMRMRDDSPMRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY30</accession>
    <name>A0A2R6NY30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000689">
        <property type="protein sequence ID" value="PSR79685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY30"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR79685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27518" checksum="397DBD0D4F1B6657" modified="2018-06-20" version="1">MALLPYLWWTTIFTILTTLWQDIYHWSVISVALRMIPIGALAFAASFSGPLSRKISPKYVLLFAQGLLVIATILLALADSPDKYWKMVLPAFVIGSAGAMLTYTHTNIAIFRTSPSSMAGTIGAIFNGALQLGSAVGIAAVSSIETSVEEKNGDPKGYAGRAAAFWFLLGIIGVEIISLLVFYRVEAEHMSPNKTQVAADEEKGKVEVEDEKARVETSEGDSPVTESPLEDSDDFKKVNVQEGDHEIREEFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY96</accession>
    <name>A0A2R6NY96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000680">
        <property type="protein sequence ID" value="PSR79871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY96"/>
    <dbReference type="STRING" id="98765.A0A2R6NY96"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26542" checksum="DF7BA0A1DB5F0947" modified="2018-06-20" version="1">MVGMTQKDSYVGSVFPISYFVRKHSPDHLAALYRDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAFYVNIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHSILRLDLAGRDLTEYLVKHLMDRGYAFKTTAEREIVRNIKEKLCYVALDYEEELARASQSSAVEKSYELPDGQNITIGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYI3</accession>
    <name>A0A2R6NYI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYI3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="13752" checksum="8DB2EBE8A30052B3" modified="2018-06-20" version="1">MESHLICQVLEERRDTRTASARTTPQRHFSQITCRREADQPPTTVPLFMESPAPAVPLPFTAWPGGVVPLGDRATVGLVFDRVNAGEVVVVIRVGVEAVGDDGVSDDAEPRSFCPMFGTSRAVGVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYU1</accession>
    <name>A0A2R6NYU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYU1"/>
    <dbReference type="STRING" id="98765.A0A2R6NYU1"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="830"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="861"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR80699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1216" mass="132688" checksum="D8101850A15F8B55" modified="2018-06-20" version="1">MDLTEIQPPTSRKSLGRRVSFASHAHVRLFEVQDPNASASSVDPGSPRHVQESDEENENENEDNAPPSHDVNRNRRRSSSSRRRSSTAFSEFGEQSMDMDEDDTAPIPQDFLGASAIQDEEFSEEEGDDFGEDMEMTEAIPREFLRKRSLSLGGPSGSFVPQRRRSSIAPITTSSQSHSENQVHHYQANQHIQQQQESIYPSLELEDILNLPEDTDGDGDMPHGEDPDHTTSTVQSGADEDMTGMTESSGGDDTQPMEFTIPVIRPPSPPPDVWHQLRAMTHAGESEPYEPPLLESDDDPEANAIIPLDEPRGDDGDTTSMELTDALTRLQRARTSLGLGADNTGDYTGDVNAEGNSGLQDDTFTSTEDSFNDDMSGLFGHGDRTVNVTTLRLSMESAAGIQRVDESMEVTSVFGDDEVIQNPIGVGNPSSQTSNLPDQQHQPPPAQPSNAAEPSTSSGAFSQPSVFSAPVQPSVFSAPPSTSVSRSVFSVPAPSTSSDITNPPLSHPPRSPLRPPPTATVPQPFTFSLDTRLGPSPAKSKIPLSSATPSKIPAPVFKGIAAFAPPSAPKSPKKRPAPEDDDVDWNMPSPQKKQVVGRLEPARKAVFEQPQNATAAEAGKEMRRASLAVRRPSGYFAQRKSLSGGVLPTPEPAVSTTTGTTSANENTSGKGPQKKAGAGLGLGRARASVGSAVQPPAGETEQIYPDVSGILEEETAAAATAARRSPATVGPSPAESGVEEPRELRGRTIDGPSEKETSVAVVRVASPAQSLPTSTSTLNRQPSQKEPASSLQEPTVTITQPGDDMDLEEEQIEQTEQWRDEFDDEEDEMFDGEGDEPTISVEQFFEMTGIKFMDQITAPRRSTIHPGQLHPPNRRRSLTASRSDEEASPDPVPLAEFLIAMAVEVPQLELYGVLAPELSAWIEESKKICIQAEEDAVKVTPALFREFAAADESEKSDLLHQLKLIKAHNIGMAKSQWYDWKSQWVGQLQNSAAEAFSNLESDAKVLEEIIGQAQEILPGLRDEYDQVMRELEKEEKDVSELEKSDKDYLNELKMTIAEQDTEIQASQANVSEAKAKLERLEEKLVEIETQKQENSSAIEEAQRIVHIQTESTSSEVFRLKAELEALQDLHLWRTTKIDASLMQFVYAARFDVSIPCINYKPIMADIAVHRTKGARTKERDLFPQLTQVMLGGVPHVLRASPGEVNVPWVRNHLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ99</accession>
    <name>A0A2R6NZ99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ99"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ99"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR81154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="150" mass="16926" checksum="E448374A598309FA" modified="2018-06-20" version="1">MSSSGVVVAVNDEPRTPLPPTVQVSLPPPSSSANSGLPFNEEAKLVYGVVLSLRNMFKKLSGRDDHFVNYRTSTYKLHLYETMSGFKFVMLSDPGTDSLRFVLRQIYAGPFLEYVVRNPLANMDSREHGIDNEYFRTSIDRMIRGLSVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0Q3</accession>
    <name>A0A2R6P0Q3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000604">
        <property type="protein sequence ID" value="PSR81915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0Q3"/>
    <dbReference type="STRING" id="98765.A0A2R6P0Q3"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="320"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="442" mass="48931" checksum="BE16FECD422E7FBB" modified="2018-06-20" version="1">MSPLLHRSRKKNDEDAGDKNNNTAQLAEQIARLNLGFEPRTRPQRQSGGFVGGFDVERPTPKLNPNSNLYPARNSYENDGPSPAFPQPNTYHASPGPLPTPPMYMPVPRTNGRPQLSVTMQHALLPTSAGSQTQGGLRPPEAQLPPRPYSDPGKANPSESISARLPSTPARRSSGGKSQTPSSVPAKQPRKKLPGDVQTTTPGKRRRAVSTPTSPTTSSTGIPDGKVQCSGMTKIGERCSRRITPSFTCDPTVEGEVEHYCHQHENQVLGPSGFYTKKTDSKAAEWIKFEDWIPEYLQKNTRAALRAEMEKPASKHDRDGYIYTFEIRDENNPGEIHLKIGRAVSLVKRIDEWTKQCGSKEQVLRGYWPGGLEDDDGPLMRGRVKAGPQGPLCHRLERLVHIEIADLIMNTPYLHPQFPNVDAESVKSDKKRTVKKKCPDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P151</accession>
    <name>A0A2R6P151_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P151"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015306089" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="41438" checksum="D8F94D90E81AEF86" modified="2018-06-20" version="1">MPSSNAVLVTLSFALLVAAGPSHWERASFTLQNGLDAQSLNAKFATLSASTPCTSGENACIDGAFAQCSNGQFVTFPCAGGLTCVALPLVNSPGTSITCDTEADAATRIANTGASGGISGRSLESRASFTLQNGQDAQALNAKFQTLSASSPCTPGENACVGGQFAQCVNGQFLSTPCAGGLQCVALPLVNSPGTSITCDTTADAAARIAATGAAGGLSGRSLEARDAVAPPACAAKATKRSEFSKRFDGVPSIAKRIAQTDLPALAQSWQNLCIVSGGDITTNTPCVTLAGVNGINALLANADPCAQQVNADAMIDFAKSAGITNKQALIDNAITYAKHPRNALNINGVTPSTPFCAQAPKNAELKGIAHAQLAGVNPGLFGSPALGIFPFGQAGTCPFGTTPDVSTCTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1K5</accession>
    <name>A0A2R6P1K5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1K5"/>
    <dbReference type="STRING" id="98765.A0A2R6P1K5"/>
    <dbReference type="OrthoDB" id="2688570at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7542" checksum="295E2AE718DAAD1F" modified="2018-06-20" version="1">MFPSAPNATGQSMNYAVVVGGGWIILCLIYYYFPRYGGRYWFRGPIFNVYAENLESEEKSSVSIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1T1</accession>
    <name>A0A2R6P1T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000554">
        <property type="protein sequence ID" value="PSR83713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1T1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7062" checksum="1F9728692EB9299A" modified="2018-06-20" version="1">MIGGFRCSRAGLNSNVIIKVYAQKGSDRNPQVTQVGSESVPVQMIIPSSPGDMIEVIQNTDTNALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2C2</accession>
    <name>A0A2R6P2C2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2C2"/>
    <dbReference type="OrthoDB" id="2742759at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR84237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="720" mass="80238" checksum="785AFC15E1A5DF03" modified="2018-06-20" version="1">MNPPLEPEPLKVTAQGLHHYACTTLRAPEIRKQLCTEMGGSFVGPMPIEDFLTSFMPVDPGRMPSTPLVDFSEVAAAPSEPKMYGPLDISGRAQDGTKLKPDIGGFEGGEMHLYIELKLSERQDAFYDPHNSGDRIEKQTDLSSKHRGQIIHYAAEQMAAQHRVSLFSISMTGRNARFIRWDRSGAIVTETFNYVDSPHFLVKFLGRFSELDAAQRGFDTTVMRADQHEIAALSNALEGHTDSFGKRLPTELEEDQAGQQMAYKVPVIIGNGTRTALVVGKPFCQPLSPCGRATRGYIAWDLVQEKLVFLKDTWRVVSPGSLSESEAYERLEGHGVPHLPTVIAAADVMDPTGIYQRTLTQDFAAHAWCRPHDSLRLLVHHRVIQELALPLSMVRNSKQLVKAIRDALVGLYRGIGNLPQLLYWVTRINHMKHNSKHFSMTLFDQLEEKPCHQCGLVHTYGGSMKTYALTSSEFESVVFDCGPLNHLICGLTEQVYTRLQQRRTFSATTRANERDNSDMDEAQPYIELFDEALGRGDWLVEDAVEDQLPPKSALQTSQAHEKARTASFSNPSLSISTKVVRTSQSLSSTIAGMVMRSGSLPPDAWQTDNVSSASRKEKPIRVRHRHNVKRNASPMGPPPLPAILGERPVNASHSSLAVRFASLDGITKGPEARPRNLKRARDEDEIDEFLPPMKHPRTGMQRTSPRSSLTRSTSKTDLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8T8</accession>
    <name>A0A2R6P8T8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8T8"/>
    <dbReference type="STRING" id="98765.A0A2R6P8T8"/>
    <dbReference type="OrthoDB" id="2649667at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="66"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR87384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="156" mass="17958" checksum="B97B031C179E52CA" modified="2018-06-20" version="1">MTEDSSDEIDFDEELLRIDKDILSLFLGWSNFRDNLADFLNTTRVLNNMPPAPQNSQFNILDDHYENREHEFRRQLVSLLHNCRIVDYVVGHTGIAHDSTAFQCTQIAQENERLKYLSDGSWIWVNSAYPLTPWCVAPYKKPAGGQVTKDQSPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBZ0</accession>
    <name>A0A2R6PBZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBZ0"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR88745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="221" mass="24602" checksum="ACA4EAF64224A9EF" modified="2018-06-20" version="1">MSHNHSHGGCSDECHDHDIPESEGPRDNLYTRIDRDNTVAMNAENGSGPEIIKPWHERMNEDIFLDSDADDQMIIRIPFTGAVKLRALLLKTGPTDQTPAKVGIFSNVDHLDFSEIASGKPTQEFEIAQGREVGEYHVMPAKFPAVTSITLFFPASQGAENIRIYYVGFLGQWTERKFEPIITVYESRANPADHKRIPGTDGAIWSPDLAHDLEGGSAPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG62</accession>
    <name>A0A2R6PG62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v4841</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG62"/>
    <dbReference type="STRING" id="98765.A0A2R6PG62"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071265">
        <property type="term" value="P:L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="16">
        <location>
            <begin position="436"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="441"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="441"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="666"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSR90692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="765" mass="84606" checksum="36233B9AA4F313DD" modified="2018-06-20" version="1">MVASSVLGFPRIGANREVKKAVEAYWAGKLSADELTKVAAEVKKTSWTSLKERGVDLIPSGDFSLYDHVLDHSAAFNVIPKRYLGHNLSPLDVYFAMGRGRQADGVDVPASEMKKWFDSNYHFVVPEFSEETDFKLLFNKAVEEFNEAKAAGVSTRPVVLGPVSFLALGKAAKEAKPGFQPITLLPKLLPIYKQLLGDLKAAGAEWVQVDEPFLVLDAASNLEKQFAIAYSELAPVSPKILLTTYYGRLDSNLKFVAKLPVAGLHIDLDRAPGQLDEVIAAVKPTNLVLSLGLVSGRNIWKTDIEAAVKLGQKAVEAIGTDRVIIATSSSLLHTPVTLAAENKLTAEQKDWFAFALEKASEVSTIAAVISGSQDAKVASAYEANKTSIAKRREFERTSDDAVRKRVAAITPDMLNRKSPFAVRKEIQKQKLNLPKFPTTTIGSFPQTKEIRTARAKLGKKEITEEEYNEFIKKEIESVVRFQEKTGLDLLVHGEPERNDMVQYFGERLHGFVFTQNGWVQSYGSRYVRPPILVSDVSRPGPITVEWSKYAQSVTTKPMKGMLTGPVTILNWSFPRADVSREVQCKQLALALRDEVIDLEKGGISAVQVDEPALREGLPLRKADWAEYLGWALPSFKLATAGVTDALQTHSHFCYSDFDDIFTSIQDLDADVISIEASKSDMKLLNTFKHYGYSNQIGPGVYDIHSPRVPGEQEIKDRVAAMLAILPADLLFINPDCGLKTRGWKETETSLVNLVNAARWARQTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ54</accession>
    <name>A0A2R6PJ54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000484">
        <property type="protein sequence ID" value="PSR92021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ54"/>
    <dbReference type="OrthoDB" id="10639408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR92021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="223" mass="25226" checksum="1848B87FFC2CADA3" modified="2018-06-20" version="1" fragment="single">FTIHPDAEVNIESKELMHAGRWTFVRQTFTRLNRCIWQCPEPFLNPVFLNLSTSLIIQHIEKDLKYWLNPRGMEPVEVRKHFALGTSRHFTLSGHEQNETLVHNEALSIALDYVYVLGNIHGKISDRTTTSHLRWVPDTTPPPEYPSPDFHSLLKDSSGVSAVALCLRHPGPYDGGVEYMFEKIIKPAIDLLFRSMPVAILPGTDCAPPPMTATNTTFPLLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN26</accession>
    <name>A0A2R6PN26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S53 activation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN26"/>
    <dbReference type="STRING" id="98765.A0A2R6PN26"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015310915" description="Peptidase S53 activation domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53 activation" evidence="2">
        <location>
            <begin position="33"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR93806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="328" mass="36484" checksum="F5A33F031745B60F" modified="2018-06-20" version="1">MIFPLLLSVFLPAFASAVPRELVARVKESIIPPREWTRQGRAPSHLPIELRIALPQPNFSELERHLYEISDPFHDRYGQHLSQEEVNELVTPHPDSIDQVNEWLASHGLSEEEFSRSPARDWVKVKVPISLAETMLDTEYYVWAHSASGDTIIRTTTYSLPEHLHEHIELVQPTTLFANLRAMRTTFRFDKEVPTTVAANAPPINVPTASGGHVDASCNFTVTITCLQELYNAVGYVPSATIGNKIGITGYLDQFANIQDLQSFFAKQRPDALGSNFTFISINGMRYRVFFNLSLNNYLGGLNNQTPADAGAEANLGMCTIAPSSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN43</accession>
    <name>A0A2R6PN43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000465">
        <property type="protein sequence ID" value="PSR93884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN43"/>
    <dbReference type="STRING" id="98765.A0A2R6PN43"/>
    <dbReference type="OrthoDB" id="3204217at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="512" mass="56255" checksum="C8F1F356EF6EE30C" modified="2018-06-20" version="1">MSEALPLLRAVIRECHRFLLAHPDPSLVFTESHPLRDSKSPEAMTPTEERLVRDWTSDSADHSSRCSNSTSSSSKSSDPPTAFHAIFGAALFFMGTIIAQDSTLALPDEPSNASTYWLAALDVFETGENTPSVMFGRGDFAEDWRMAVSWGRTLLCIADEKLEHSLHGSKGRPTPMSTVQTDFQNSWCAYQPPTAGPFSASEPRWPKSSPFHAIAAARPPVTRRMSLFSATAHDVMVLAMDQFSRGIFHMPHPHYPHTHNPSGLQLESPFVDGTGFSSAFHSRRHIVSCTSPPPTTSTLTFSRPKELFTIASEVLGIAERLSKAEQREYWAGQADSVFNQMKMEADMAVSRMAVNAARGRCWLVVGEARAEELEGRLEKGEIEVLMSAEAEEAREGLAMAIAFFERAKGSATAKCTAEQEDISPLLAEALVTLANLTADENKREELYARAQAEGGEDVDLELDPPQIHTPTFEIVMDEVNVNMNLKTPTSFTFSTGGVGIMMDDASMRMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNB2</accession>
    <name>A0A2R6PNB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI inositol-deacylase PGAP1-like alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNB2"/>
    <dbReference type="STRING" id="98765.A0A2R6PNB2"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="6">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR93817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="345" mass="37939" checksum="6158143B5393BDEC" modified="2018-06-20" version="1">MSTPHTLPPARFDRHIDRIYTANQDNLARNPTPILSLCGGATDLMIPSESCILPTADREVDAVQPYRRSIFTSALEGSWTGVGHLAMVWCHQVRWRIARAALELGATSSASSRSVILDTWLRDGHRTSPKIDDTYGRYSDHLDLESEEVEVLPSELNLVLNNPHGSHTYILPGYASTFSKKFILYVFQGSIIPTSPQTALPLRASVFICPPQGFCTRMIPSSLKLVPSPILGRPFPVPDEGSDESEGVVVFEADMEVTGDMRVAVKVEGADGRGWIVGGFVQQEALFNNANSVGMYSAWCNFCNSTAELYLCFSVSGIPCAYCTEQFNPYDDPFPSPPIYCSDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNH0</accession>
    <name>A0A2R6PNH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000452">
        <property type="protein sequence ID" value="PSR94376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNH0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="10750" checksum="25D57FF148078FF0" modified="2018-06-20" version="1">MSDALEAAEFHPDPHFTGEKSVWDPSLDPLFQICQFHATCQWLSRAALVSTQWAEIALDKLWHVIKDLRPLLSLLAPLSTERKPAPGGPMTFIVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVQ0</accession>
    <name>A0A2R6PVQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000430">
        <property type="protein sequence ID" value="PSR97721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVQ0"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="8421" checksum="49AAE723ED1C0217" modified="2018-06-20" version="1">MDFADSATGTQRGAHDATVRGRQEAEVGVNNIEGRHTTGTAPTQSATSGSGIATQTTTAPTVAPGTTGDQQQPGIGAGAGYGNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYX3</accession>
    <name>A0A2R6PYX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYX3"/>
    <dbReference type="STRING" id="98765.A0A2R6PYX3"/>
    <dbReference type="OrthoDB" id="2756327at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="42"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR99050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="28917" checksum="5A05250CDD4566D6" modified="2018-06-20" version="1">MSGGQSVDDVNFSFEDDHNYWAQSLCLLIQNPRISALIRAGWTAIKDHVQWDDEDTVQTVVEDIDTLLLFAGIFSGAILTFVVVSLPTLRPDNHHISVEILAEIASHFRVFESPTSLIKATGPPLLPLASFQVPSRARWLNILWLSSLVFSLSSALLSIIVKSKLRVYLQWDREMPPSRDNVVARQRRLQTWKTWKVPATISVISVFLEIALVLFLVGMMIFSWALDTAVTFVLTITIGAFLAFISAIATPPAVIRNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBK1</accession>
    <name>A0A2R6QBK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBK1"/>
    <dbReference type="OrthoDB" id="2758596at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015315767" evidence="3">
        <location>
            <begin position="30"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS05513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="516" mass="55048" checksum="69E108A9DD861B64" modified="2018-06-20" version="1">MMINTFSMTMKTTVSLVLGTLTLLNLAVAAPAPSPPPSLNPTMDLGTASPTDVNPSPTYVAVVSASDTSSDAPATVTPFFTPAVFQKDYYSYTTTEKPEQNDAAQILPVDTPPAPEPTTSDYAMLVETSITAPDMSTTDPVSTLTSVFDDVFSATTTLYSEPPPSMGTPEPVATITTTPVFTSRHFDPLSTSSPLPSRRPSAQSRVSEQSRQAAILGTIIALGFLSGLMVCVFCMRCRTRTRSQASFSPKEADEGTSGQADSLKEAEKPPVIYSNTAPDVTTLPVLQANSPSPSTTPSPAAKNPPDWPQGQQSQWRFLSIEEDGHFEDVTHILSGAAFVDMVSDSGDRNSTASKDHECSTNRTSNGVASVTAESYATCESRYSSPSIDRASQVSQGSNDASSFLVISPPESPLIQTPRQEDFVTRPRSKTVDQPCSPLLGRSISSSKSFPVRLGCHYSDDRVSQLTTASEESEWDVAEAYGARYSKNSLRMVPVLSTIAENVEVDIGGRSCILVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEN4</accession>
    <name>A0A2R6QEN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEN4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="11491" checksum="C9AA277D814117D8" modified="2018-06-20" version="1">MTATEDAEQALVKCGEHAADDTSVPISRSTHPSASTDDRAFGPPNPLSGQFEGVWSIGVHDRQIGIDYEEGIREEGIEGRIKRDSNESEIEMQETSTTRRDHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QES5</accession>
    <name>A0A2R6QES5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHLCEN_2v3599</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QES5"/>
    <dbReference type="STRING" id="98765.A0A2R6QES5"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="19">
        <location>
            <begin position="366"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="647"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PSS06643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="864" mass="97948" checksum="828C34C33F426D0E" modified="2018-06-20" version="1">MAERAGYTVTMFLVDVSPSMGKTREVEMSLPNGKTQTVEMTNLEWSLQFVKLKIQEMASFTFWYALTRFLKRVTDLQWTKDRPVWRDFIRHRSCMILGSFLALLETENIVHSKDGGYDHVYEYIPIAQPTAATLAKLSGLEPSTDVGDPIDALIVGIETQDKYLGKKKTWTRKMVLLTDGENPIEVEDWEETAKKMNLLDVRLSIIGVDFDDDEYPFHEEDKSGVKSANETFFHTFVDKLESGIVGNCALALEEISRPEVKSTKSALMGTVLRLGDVEDRPEEAVEILVKASKCTAVARPKSFKKFAVREKKDDEDIIMKDEDENPKDVYAQLAMRTEYFVDHNADKDEEDDEEPALPEAEDQSKRTVIDKEQLVRGYKYGSSYAPCPDGNFPRLETKKGIDICGFFLAKHFRRELSMGEVQYIWADPSSPVQQVALSSVVEAMYEKGAMAIARWVSKDGMDPKMGVLAPTVFENVDCFLWVQMPFADDVRKYTFASLDKLINKKGEPVTKHPYIPTEKQLEAMENFVDAMDLMQAGEEDEEGNREVWYDTRYSYNPAIHRTKQALFHGAVVSDLRRQPLPPPHPELLKYFEPPKRVLKRARHAIEDVKVAFKVKEVPRRVVRARKDGHFAAQDDDNMLLLDKVAPSRNKPSRIPQSQSQTQIISPPKSQKAPLAKKGNDSDSETESEGEYSQHLLLDLKRARLDEDTEKGNEGESMLPTPLHSPSRDISGREPGMIIGSVHPLEDFKRNIASGDLVTKAVEDLGTVIKTIALKPFSESRVEEMLECMQELRRVALEEDEIDAWNAFLRDLKRECVKDEESGSSDFWRRVTELGRNISLIGQLEAAKLGGDSDVSEAQATAFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF37</accession>
    <name>A0A2R6QF37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000343">
        <property type="protein sequence ID" value="PSS07206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QF37"/>
    <dbReference type="STRING" id="98765.A0A2R6QF37"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="393"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS07206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="565" mass="60975" checksum="1204BCC98138068C" modified="2018-06-20" version="1">MASTEHTSETADQDSTVEEVQAQSGLTQLVELSSVQNGNVEATAADNSAHPAHTDVGSDVAGASGNKADTSEPGPVPSTSTEPAKAGPSKDVFISQPSAVSASSPSSKDKADEQDRPKDAEKDRASLNTSTATYTRTQSTRRKDAKSASENAHPASTPPESPRKSKPSKKAKGKRSLFSRLFQVFVPCVAPSTRTHAVDIDVPKHQPSEPVGIAQPDLKEKQTAKEAQELPPRPEPEPPLTVLDTAPPSHEDVPELPPPTEDVPLKREPTPVPPPLQPIDVPSSSDDPTVVVPPTPTKSLLPRDETEGVLSGAVQPPGSTGDEIGHDPHQRRRDSLHDSDGSTSYTEDEDLEEGPPVDQIEDEEERLILQGGAGIPIGPDGVPRPLLPPLSAKHAGRKCLVLDLDETLVHSSFKSISQADYVVPVEIEYNWHNVYVIKRPGVDNFLKKMGEIYEVVVFTASLSKYADPVLDKLDIHRVVSHRLFRESCYNHRGNYVKDLSQLGRPITDTIIIDNSPASYIFHPNNAVPVSSWFNDPHDTELTDLVPFLADLSQVDDVRGVLDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIL3</accession>
    <name>A0A2R6QIL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIL3"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS08838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="227" mass="26422" checksum="3DD3CD28827B1FD9" modified="2018-06-20" version="1">MPKILKPRVEELKDEIRLRMPIPPPPPPPKSQSSTRTRYHRQCKKEPPVEAPKAPDTPKVSGYLLYDEIVKWEERAHAGGNHWLDSHDLRRRTRISRRDPQREHFNMLVSLEFKEPKGPRILCNLSKREYVREGPLWQLCKNSHNTVTLGEALVCRICWTDEPYICLGGEGQNMPRGAWSGDRFVVTTANRVPDLADWTDVTKDVVEELKCYWSFDNGDDWPNNARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIN6</accession>
    <name>A0A2R6QIN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v3456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIN6"/>
    <dbReference type="STRING" id="98765.A0A2R6QIN6"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS08841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="191" mass="20421" checksum="08B9C13527C27C4C" modified="2018-06-20" version="1">MSDHSIIKEQPGPVPSPSVNGGDYSTPGPLTLRTRARHVVRKLTTKEGWLGDYDYAWLCTPTLPFTVGGKKRRTSPPFYALDSELPLLLALGCGLQHALAMLAGLITPPIIFASALNLDGPTSAYLISASLIGCGILSLVQMSRLHLFKNYYLGTGLISVVGTSFATLSTANAVSRLFGESGSLPNWVTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM60</accession>
    <name>A0A2R6QM60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PHLCEN_2v3306</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM60"/>
    <dbReference type="STRING" id="98765.A0A2R6QM60"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000085">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="920"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="972"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="998"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="192"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="860"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="813"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="836"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PSS11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118277" checksum="4AAE5B1B1DB01013" modified="2018-06-20" version="1">MNSRVAATSARTTRQGKRRERYEDDPEEEATLLGEEHRDGEGRDLEDEVHEETASQISTVSRQTKSLGKDKSRTVPFRPPEKLQKKFPPNIVRNQKYNAFTFLPIVFYEQFKFFFNMYFLLVALSQFVPALKIGLIATYIAPLAFVLCVTIGKEAYDDYKRNLRDREANSQKYLVLEPSSYSASEPECGPHTRSVPSSQLAVGDLVLLEKNQRVPADLVLLRTSDASGTCFIRTDQLDGETDWKLRVAVPACQKLNNDTELLALDAEIYADAPIKDIHTFIGTFTINTPPSVSQNELPMVPVPTIEPLTAENVLWSNTVLAAGSAVGFVIYTGLETRAVMNTSHPETKVGLLDIEINRLAKILCTVTFALSFVLVALNGFRGLWYIYIFRFLILFSSIIPISLRVNLDMGKTVYAQQIMTDTEIPNTIVRTSTLPEELGRIEYLLSDKTGTLTQNEMEMKKLHMGTVSYGFDSMDEVTHQLSMAFGATAETGHGRNPSIATGVQIANRGRRDMSSRVHDVVLSLALCHNVTPVRNDDGSVTYQASSPDEVAIVRWTESVGLTLTFRDRTRIELQTPAGSRLLFEVLELFPFTSESKRMGIVVRDTQSGEITFLEKGADVVMAKIVQRNDWLEEECANMAREGLRTLVMARRRLSEQSYAEFKQQHHQASIRLEGRNEAMATVVSEYLERDLELLGLTGVEDKLQDDVKSTLELLRNAGIKIWMLTGDKIETATCIAISTKLVARNQYIHQIAKLKTSDEIRHQLDFLQNKLDCCLVIDGESLQLCLNLFKTEFIEIATKLSAVVACRCSPTQKADVARLIRHHTRKRVCCIGDGGNDVSMIQAADVGVGIVGKEGKQASLAADFSVTQFSYLTKLLLWHGRNSYRRSAKLAQFVIHRGLIISVMQAVFSSIFYFAPIALYQGWLMAGYATVYTMAPVFSLVLDRDVNEDLALLYPELYKELTKGRVLSYKTFFQWTMISVYQGATIMIMSLVLFENEFLNIVAISFTALVLNELIMVALEITTWHMYMVISEVVTFFLYALSLAFLPEYFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM97</accession>
    <name>A0A2R6QM97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM97"/>
    <dbReference type="STRING" id="98765.A0A2R6QM97"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="81134" checksum="C1C4280185D6854C" modified="2018-06-20" version="1">MALATMEILCTIPIATYGTYLNLTLYEVQPWISWSDTHFNYSHVNLYPSILWRMDRIGTVSLELSRSLPVFCALIFFCFFGFADEARRNYRKAYFAVISLFKPVRGFRIFRFRSQEFEQHVTLHVRNSIWPVDLETAILSLQNTPDVSNIGPASRELPRSLPTSSIADPIPVTSTNLTSQQVHPTEDNTFDSLLRSPETQDAQSPVIAQEPTALSATPHPSPQSQPVTVASPTTTPPSQLPTSASTPIPQPAPAASHPPPQISTPISQAQTQQLTDSQTPVQHTPPALPAYQYVPYLYPQHQPGAYPHTPQQAAYPHAPYYPPVAATSAHATSSVYPAYSAYPPYPPPHSYPPHPQPPPPTEDLPNYEDMIVEALTHMGTAAPKHLFAWMASRWPLHNNFKASANQALQKAVQRHRLEKLPGSKYRLNASWEGGATSKRATRRPQTLAQATYAVHHPTQRPSSPFTHAPLPHRASPASAAPAQHQPYGYPYAYTTAYPGYAPYASYLSTAAGTPGNNTPSVTAAKTTVAVKTVATADAISEKVKEKTDNGASAAAGANDEAGDAWVAAQHILQAINFAGSSSQPESSSSAAVSNGVQPPIMDSLDINYNLNLDRAVGTDATGDDGLGRAALTDEERAALQAQLALLAAQLSEIADLEDDGVDTDVTTEHMDQPLITEQPPQRVLIDVNQFPDVEINAPTTMDVHTVITATLPSLTSNGISALDNLIPMPAGGDLEEDEEMEMVDVDDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUG6</accession>
    <name>A0A2R6QUG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000312">
        <property type="protein sequence ID" value="PSS15391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUG6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS15391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="498" mass="54653" checksum="417E2A905B34D21D" modified="2018-06-20" version="1" fragment="single">MPSRKTKAARPAIVLGLESDPAPANLPPRRSKTKAIEDQDAPKRKRKPEDAIDNVVVAHHPEQAKKRREDVEKVSKPNQTKNGTSTKQLPNMYIVGPAFTVGNTDTPYEAGKRRRPVLQHSELLADEDEDAGVVEKQVSDTPLPPKVVVTADKRQSRQVKKNPAFVSNSKKGPAPKDTQSGPADGGDGDDSAGSDGDEYEAGSDAQSDMDASDNNEDLTCLEKHPNRLREAMLQEIPQWVVIDGPVISGGEDSDEHQPPVQSQSLSRRYSQASQSDGPPASTLAATSDDEGDSAAEENVSDSDTEDLFADDRKVAYASRVRVKADHRQPQGKDVVQRHGKAQTAPKVMSRREQAVQKERPRFKTAVADTNTITDTSDNPIQVGRTSATVRQGRRTMETMTEWEKTWPLSTRLLYNSRIKVNIGAQSVGIQRVLKSSIEELIADFAFGTAVYPADERISAQRSVVVSVATRLAFKEIGVRLREEWEYAKEFVEVVGDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R771</accession>
    <name>A0A2R6R771_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000277">
        <property type="protein sequence ID" value="PSS22608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R771"/>
    <dbReference type="STRING" id="98765.A0A2R6R771"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000025">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS22608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="447" mass="49418" checksum="B53940353A91BFBF" modified="2018-06-20" version="1">MPEPKSDWFDVLDQENRPVLTEREILRNLQAIVTDADKLPVHEVARNSIGVLSTENRKVWSSLRKALVRNRNNESCLEVVDNALFVVCLDDATPDNLAELCNNFLCGTYELNAGIQVGTCTNRWYDKLQIIVTADGAAGINFEHTGVDGHTVLRFAADVFTEGLMLLARSINPSAPTLFHAPLSPYAKSYKPPRSHRGHVSPPVQPTYLIDTAPKKLEWTLYPELRAGIRFAETRLSDLICQNDCQALEFKGYGKNFITSHGFSPDAFVQMAFQAAYYGLYGRIECTYEPAMTKAFLHGRTEAIRTVQPHSAEFVKTFFSDTTPAQKMNALRKACNGHVKLTKECSQGLGQDRHLYALYCLLQRERESANSEDRPLSPVSNCSSVSNGNNKAPLPAIFTDPGWSLLSTSILSTSNCGNPALRLFGFGPVAADGYGIGYIIKDDGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7H6</accession>
    <name>A0A2R6R7H6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000267">
        <property type="protein sequence ID" value="PSS22692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7H6"/>
    <dbReference type="STRING" id="98765.A0A2R6R7H6"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF302" evidence="3">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS22692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="824" mass="92313" checksum="7608A7C0E8BB6E49" modified="2018-06-20" version="1">MSNDVGKEVINYTAQRVVFTSTKPFKEVLAALDEELNKDKAGMRVLQLLATATSKEEIEQQLDAMLDGKRDFLQVPPIPTCRFFSAGSHARWMNILNGGNPQLAETVVVTLGNPLIAKNIIVHNMQAGLYVPPKILVQETGDSGTRIVYDLPSSLMGGGKLEGDMETAALGLDGKLERMVQKMLLRRRANGPRYDSDNAINIAQADKEPEAPHDHELEHPGTESAHKAEKLKSEGNRNDRRFYATRRFLFPLGIIVGILLGFILIQPSDLTDFQTHLALLLDEFEFEISMPQFPQLDLSMVENEWRKLRSSIPEPWKLNNNGLEFTVGEAIASRGLTAKYPIVLVPGIISTGLESWSTTPEYRPFFRQKMWGGFSMISQVTFNREKWMNALLLDPVTGLDPPGAKVRAAEGIDAASMFIQGYWLWSKIVENLAVVNYDTNNLHLAPYDWRLSYYNLEVRDSYFSKLKTTIEGFSFKWVESPAHGNGGTDWVEAKAMAAFLSGEMKDTVQMNPAGAYVLERFFSRRERRKLFHSWPGSASMWIKGGDAVWGNANFAPDDTSINNYTHGALVAFRDSILQETSNASLENMTADAAASWILERTPSHFQKMIATNYSYGIERDEEQLKKNNLDHRKWTNPLEIQLPNAPTTKIYCVYGHGKETERSYFYTRGEFEYDDVQADSSPAVCYNTSDCLTPRAPLDMPMFRKSSIDAEYTDDNVMPKILNGVKMGEGDGTVSLLSLGAMCVEGWKRKRWNPAGMKVVTVELPHSPVPTIPRGGGTTADHVDILGNIALNELILKVATGAGDEIQDSFVSNIQEYSRRVQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHQ3</accession>
    <name>A0A2R6RHQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000260">
        <property type="protein sequence ID" value="PSS29547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6RHQ3"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="9674" checksum="01C1E45D5959AE10" modified="2018-06-20" version="1">MGGPREAAASVAGAIVGHLWWWGVYHTRTLEAFGKAPRWLRAVIDGPSRPGNAGDATAGPGGVHVIPPRRVREEAAGTSSGYRWGTGQKLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPE1</accession>
    <name>A0A2R6RPE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000215">
        <property type="protein sequence ID" value="PSS31908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPE1"/>
    <dbReference type="OrthoDB" id="2800083at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="434" mass="49709" checksum="33355A2F96F50622" modified="2018-06-20" version="1">MLATAADLPPELFKGVIHALVDDYEHTPRCKREFGLASLTCRYFAEQCRPEIFYQIRLESREDVLTLISFLGSSISRIKDYIDKIVVTQYEPCEPWLHLLHTSLMYRIPHAEIEYFKLTAKTSSPTAVKLQSLHTGPPTSTPPACWNIKRLYLVKLQLNSFSYLVKLVAGLPQLELLFCERLTWPSLPPDSLPDLRRYSHKNQRMGEVSMKGCEEHWPMLWFNPKIAQIDRGDVRIMSRLGRCIENLNRPGVGEMTGYLRSHVFFRKGKLDVRTIFIGSKCWYQGPDLVLSFNNEQPKSLVKLRIIFHGCVGASIQCINWQEFDEQASCLRNLGAAEFCFEKRQSLAFVRSMAEIIPRLTRLRNADKLRATYQERCGKPTSNVDINDLERNLVALGGIKQEPSTPKPALETESVPPDTDATDLQMDTTRVNEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPF8</accession>
    <name>A0A2R6RPF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000215">
        <property type="protein sequence ID" value="PSS31912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPF8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS31912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="17753" checksum="08E275CB5572AFE4" modified="2018-06-20" version="1">MAMPNVSTNTCESFIETRSSVLATEIKEIKNLATTSCQTTQQARRGGKAETVAGTLESQMDRVSSKVRDADKSELLRRNEEENESDKFKSREPPRNVTALRLPTGSRLPSHCPCRRTVSTRPSPLSHLKNLERYDCSIAGIAIVATTVATVLVIARGVERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPS1</accession>
    <name>A0A2R6RPS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPS1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10773" checksum="575079CB1D11B649" modified="2018-06-20" version="1">MDGVMTGIRVHSSDAAIAKVRHLRQTKVMASQLTVFRRSFRVHATGFHWSSTRLVKILRSSSFGRGFERVMVAGSIFKELHRAHRMQESSFVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVU3</accession>
    <name>A0A2R6RVU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000149">
        <property type="protein sequence ID" value="PSS34147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVU3"/>
    <dbReference type="OrthoDB" id="2576082at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="298" mass="32107" checksum="48D62C08A8763839" modified="2018-06-20" version="1">MPVFNLTIPDTSPLIAYDGTWGDSSHIDSAWVDYANGTFHATQEYGASATLIFNGSAVYIFGARRDNHDYYTTTLDGMSTTGYGQSNTPIFNSSLFSATNLGGQQHRLVLTNTFTTPADPWVDIDYMVITSGDGNAQTQSADVWLDDGAHNITYSDGWDTSPNGLEASYYMNTMHRTNVNGASASLLFNGSAITVYGATSTDYGLFSISLDGNDPPLLLNGSAPVFRPQNMLYYAGGLSDETHNLTFTNADPNGSWFDLNKFVVSTWPTFETVATSSSSSFTQGPDPTLLSPSQADPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVW0</accession>
    <name>A0A2R6RVW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVW0"/>
    <dbReference type="STRING" id="98765.A0A2R6RVW0"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16425" checksum="49AAC8315E452409" modified="2018-06-20" version="1">MPEDQELKARRRADYSSDNDQYAHINNSVYYHLFDSIVNTYLIDHCGLKPPDSPLIGLVVSSFCNFFAPLSFPGVLDLGLRVNKLGKSSVTYEVGVFEDGKEYPSAIGGYTHVFVENQSRKSATIDDRTRVGLKKLLQVPANPRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVW2</accession>
    <name>A0A2R6RVW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVW2"/>
    <dbReference type="STRING" id="98765.A0A2R6RVW2"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="194" mass="21931" checksum="08230C07815E23B7" modified="2018-06-20" version="1">MEVSFAMTGKGYVLLAADTTAVHSIIKVKTDVDKIKELSPHLLMAYSGEPGDTVQFAEYVERNIRLYQIRHTYPLRPPSAASWIRRSLAESLRSRNPYSVNLLLGGYDTSTYTPHLYWMDYLGTLVEVPFAAHGYGSYFALSLLDRYHDPEATVEEGLAVLRRCLDEVSKRLVVSPGKYKVKIVDKDGIREVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW13</accession>
    <name>A0A2R6RW13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000140">
        <property type="protein sequence ID" value="PSS34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW13"/>
    <dbReference type="STRING" id="98765.A0A2R6RW13"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16225" checksum="A6C26562D0DA4BE2" modified="2018-06-20" version="1">MAIENSRHYQVDGPDVQLEWDSIYPGGDLGFIRLGPRKRFFGLSLYHQIHCLESLREAILGQGHGEGHSGVDHSSHCLNYLRQTVLCAADLTLEPEITEGTQDVGEGIAVTHVCRDWGEVHAFVQRNWEQWEALKESNGTHPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S439</accession>
    <name>A0A2R6S439_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S439"/>
    <dbReference type="STRING" id="98765.A0A2R6S439"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="415" mass="46649" checksum="3BC0109D258CD704" modified="2018-06-20" version="1">MEQPFNISVSQNTLDSLAQKLAVATLPAPAPVTYTDSALDSEDWTYGVPRPTLERLLIHWRTSFLPRWQEHQAALNALPQFTRSIEVDGHGVFTAHYVHKQSTHNPKGAIPLLFLHGWPGHFNEVSKLLPFLTTPPANAGYPSFHVVAPSLPGFGFSSAPTKTGFAMAQYAEFAHKLMLSLGYNEYVVQGGDWGCFIAHRLAYLYGPKHVKAWHTNMPAGRQPTFTRHPLLYLQHAITPYSAKEKKAVQRMQQLRNEGRGYFAIQSTMPQTLSYALADSPVGLLAWIYEKLVKWTDAYEWGDDEVLTWISVYLFSTSGPETTLRIYYETVHQGNFDEFAKLWSPIPLGLSFFPCEFIDGPRTWARTMGNVVFESDHDKGGHFAAYEQPQALVDDLRQMFGKGGKAYGVVKGKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4B8</accession>
    <name>A0A2R6S4B8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4B8"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="21220" checksum="B84C64E8BBA53887" modified="2018-06-20" version="1">MDYMATSAPSTGSNSEATDVSMTQGGDLPVLYGLVSLLVQRELVTQEFEMRVDGVTLVPNYSSWGRWQNLQFLFLISFIRLRSTSSSQIGFLYVARVMEGDVIGCGVDFDDEIIFFTKNGVLAGKYMLLNVVSLECLNMQTGVATFTSYNIERSAKLSSRWHMIIRPLASLSTPAIPPFNGIYAARMNTSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4H5</accession>
    <name>A0A2R6S4H5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4H5"/>
    <dbReference type="STRING" id="98765.A0A2R6S4H5"/>
    <dbReference type="OrthoDB" id="428177at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="36"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="316" mass="35029" checksum="422E5CAD96FF5456" modified="2018-06-20" version="1">MKVLHVWLDGQSTSQKGTNIDPFPDLEPTQICNGAANCYNDTVLQRLDDFMIDANSHGIKLIISMHSFNALQAGDVYGREYGTGYFYEQAYPQQAFDARLQHVMNHVHTTLGKPWKQLNDYIFAFEAENEAMIGKGQQYIEDHQQWQCDRANTIKNELAGNTGILIITGGESWMDESVQPGFLSCASLDAISIHAYGTGDYATSAIQTYVQRAQAAGKKLLMEEWGACYFTTENNNCPSGSVLSTSTRNQNIQTWASQITAAGLPWLYWQVLPNADPHYGQDYEIGIGDASWGTLESAAQAALSANAAFDFTEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4U1</accession>
    <name>A0A2R6S4U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4U1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4U1"/>
    <dbReference type="OrthoDB" id="2775820at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="534" mass="59860" checksum="7DB891159E2676C1" modified="2018-06-20" version="1">MSYFNTLRNGQSLACLLPPEILNSIFSLTSNVFSDFSSRPLEAARREESFDWHPMCLSGVCRYWKAVALSFPSIWSTIDICDEDECPSSSSIDIAKLCLRRSYNGCVDVHISCPIPKAELPWITETLASQSIRFRGFHIYGFSFGPEILQHFAEDPAPELQSLTISPQGDFSNGSGIVLPMLFAGYTPRLRHLVLKHITSWPGNDFSNLRSLRLEDQVASCPISKFLDFLHHSPHLEDLILVCAGPSEADPAVQLRQLSLPRLRQLVLKECPAICQATRILPYIQPSPTVTIMIDRTYYNNSLTTGSNIARCNTLLATMSRFASMPNITRLLLDTFSSFDRGSHKLRLTGTGLSSFDICPSADIHEMASNQYMAAAIGLISACNIQELWIGSDHVIQKDYIWQRLLFAMPSLKKIVLGPWDSHTPGCLLALHTPDESVGRALPCPSLEELVILGRLGESKWSCEAVQKLLVNRKARGFPVRRVVLVRRTHDTSFDLHPTADRFREIVEKMEIQTVPRYPTMEGSEAARALGRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4U3</accession>
    <name>A0A2R6S4U3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000067">
        <property type="protein sequence ID" value="PSS37286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4U3"/>
    <dbReference type="STRING" id="98765.A0A2R6S4U3"/>
    <dbReference type="OrthoDB" id="2740399at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="142"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="267" mass="30421" checksum="932A1769F52BEC34" modified="2018-06-20" version="1">MQQQLLNDIQEDILKEYIKYLAFARIALSKRTISPRVEALCGRKPSRRWVYWFLHCHPDCTLGRPTGLDPKRARAFNYTNVSAHFNQLQAIFGENQILWQNLWNMDEIGIQLGGGQKGTNELYLYLAFDKSWYNITSDDLKLVTIIECVCADWSSSVKPALIFSGNKMCKEWFKEEDGILLVTTDNGWTTKDACKSWFQTCFIPSAQAHADPSKPIVLMYDGHGSHVTINMINPGMDNNIILYCLPAHTTHKLQPCDVGAFGPLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Y7</accession>
    <name>A0A2R6S4Y7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Y7"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Y7"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="577" mass="64320" checksum="7EA642399A3DEACA" modified="2018-06-20" version="1">MTSKITDYLTKQIFIEKNVVTFRLLSRQFNVHVNESKNALATFYATNATSDERAYATYLLSGEVPLVSKLGSKQNGGPAAGNEDYIDEDEVMEDVNEQMDDLEEVVPQTKMTLAGEQDLERAKSTYSRIYSEYIYCLSPSPVHDAGLICTSSDQVYAADAKLKPDVAASLGRIIGSHVHMGKKQNLVASTYKGKEPAVRVATPVVQAKEKTNEETKRKELLKEKVPAPKKEEKEPLSIKPKPTGKLDWSKAKPRGKAEEKEPQVKEKPSVADKKPKEEIKEEEEKVQPEKKGLSLKPKASGSKDTIAQVLAFKVKEEKPTKPRDSSNLEVKRGQKRKSALPADTESEEESPPSRGKSITPPIERMSGLRLKRKTVISDSEDEDEKPKPQPKLKAKAKSKIPVEIESDNEKSLRAMMDIDDEQVIKASRSRIVRAAETSETEPDDEPQTETQTEDADMMDDSDPAPKPQPRKRKQKKAIPVGKNGLKKKRIVSSRNKLDEKGYMVTEDYSEYESVEEEEPAEEVPKTKKSVAKAKETKSEESKPIKAAPRKSKSSSTEKPKRTGSGKGSQGSLMNFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5Y8</accession>
    <name>A0A2R6S5Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein MEMO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5Y8"/>
    <dbReference type="STRING" id="98765.A0A2R6S5Y8"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48078" checksum="14A7A51C4CEAE15C" modified="2018-06-20" version="1">MVKIPIIKKRTKPFKRHQSDRYKGVKEAWRKPKGIDNRVRRRFKGQLPMPKIGYGSNKKTRHLLPNGLKKFLVNNVREVDLLLMHNKTFAAEIAHNVSSRNRITILERHATHANSWYTGDGQKLDSELTTNLTAVEASHEFKPPIKGCKAIIAPHAGYSYSGPTAAWAYKSIDVTGIKRVFILGPSHHVYLDGCALSKCTKYETPIGDLPLDQETIAQLKGTGNFSEMDLQTDEDEHSIEMHLPYVRKVFEKNDISIVPILVGAINKEKETAIGAILAPYLAADDTLCVVSSDFCHWGTRFQYTFYYPKPPPSSEAPVRLSRSTSALHDLSKHPIHTSIDALDHEAMELLTMPPNTGHLAHHLFAEYLTRTKNTICGRHPIGVLLGALETLEAEGRVPHLQWVRYAQSSECYNINDSSVSYASAYVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6B1</accession>
    <name>A0A2R6S6B1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6B1"/>
    <dbReference type="STRING" id="98765.A0A2R6S6B1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="69804" checksum="5A2A38D91ECB04EF" modified="2018-06-20" version="1">MAPSPVYNNGGRDSAMLSGQMHNMRNDMYNSSGSSEHMPRSGRSFPPLPGFAPPPHKYATYGIVPSTAPSSDDESEDTLPRSTMNAPIEALQGLANAAAEAAAAPSSSAPRVKKRKKAEPTPRNAFPHVVEKGLVSDTEARELYHIFFSGCHVFIPVFDPSYDTYDGLMERTPWTFDAILAVASKIRSGTGPLSPSFYKSLEEAQGIARSSLFGPVVRKEAVQGMLLLAAWSTNGWLPSGHAMRMALDLGLHRALEKLADDNGKNRTEEEERNLGMQRMSLGTGRPIVLRDESSIRHCRLLLKHPMASPTDVRLVSQVELIAQKTQIYETLSPLNGQVNHNTLAFIRRANVALDKWWQDCDELHRMFCDPLAPSQPKAKIPTGETMDDEALPRKILAGELYYAKLWLVCVALRGVSWDKMPFEQRELAFQAKDAASNCLSNLLNSPTYSLVTAAFSGLFLLKMANLFPAELDLSAITVQVEQLAQLLSDVAAERSDPEHRRILVPLSHPYCIPPPNRYALTLRIMLANLRRKISLASSSVHNMQNTDPSLLGVPSFMDPSLVSQAPPPFTMEELGMSWPSDLRMFSPSAIPVWLQEKNLTDLGLPVNGSDGIFLQIGSTNGWMGDFPQMPEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S745</accession>
    <name>A0A2R6S745_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S745"/>
    <dbReference type="OrthoDB" id="5378718at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040887">
        <property type="entry name" value="AUDH_Cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054583">
        <property type="entry name" value="Beta-prop_AUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22301">
        <property type="entry name" value="AUDH_beta_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18637">
        <property type="entry name" value="AUDH_Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldos-2-ulose dehydratase beta-propeller" evidence="2">
        <location>
            <begin position="128"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin" evidence="1">
        <location>
            <begin position="439"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="801" mass="87598" checksum="0522FF8CB2E07035" modified="2018-06-20" version="1">MSYRKLFLGPLCDPGQPASFPLFQPQQVQGGRDDGYWIEAFPFSTLTNDCANIIGYGLGTRENASNVEMFINPFSDKADNKYDLDILSKFIQITHPYIVNPRLGKVSPLPIIICDQYGPSMNEIWPNGGRVSWLENVGDPSRPNWTQRTMGRSPAMHRLKAGHFTRNDRVQVCAVPIIVKSSDLTTPAPVIIFTAPDDPRQVQGDWPSEVVTEKHLVHEVVLVPSEGRGFDQILIAGRDGVDLIWFDGVSWQTFNVGTGLPSSPGNPYWGAGSVAVARVGEDSAGYIASSEAFHGNTVSVYTKPTGSKRGIVGNKWTRQVLHDFGPLNGEHTGSIHQVICADIDGDGCDEFLVAMMGSAPADWNRTGVWCYKLQKETGTFTKTKLSNTSAGRIAVAHFTNVGRFAGAGAREIDFATISYSVPGYFESPNPSINIFLSTGISAERLDEEVSFNIVRASSTRFTTEAEFLDVSARKLALVILPPDSPYCVAEDSSGIKVLAGALSWVDDRNKLQERTSAARPFGCQTMTVNAGAVMSGKEGAVFVVLKPSNISGAPPYSSMDQLVSHNIFPATYSADVRALEFPWVKVQDRPWAHGRFKDLEFYNLVGFHVHYADDSLDELVHMQLWTAGKGVSAGFHNHVEKSFCEIHACIVNGTGQGGMRWATVPDQNFDPEDPDLDKTELVVVPDMHEHGPLWHTGPDGHPLLRMNDTIDYPWHAWLAGDGDPNSEQSFDVWVAFEFPSFETFSTPARPPAIQPGKYSILDPITQAVVILKDDNATDGTPVLATLPGVVSSAKVRPATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDL3</accession>
    <name>A0A2R6NDL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphomannose isomerase type I catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDL3"/>
    <dbReference type="STRING" id="98765.A0A2R6NDL3"/>
    <dbReference type="OrthoDB" id="10414509at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6104" checksum="463BB01C2CADBBC6" modified="2018-06-20" version="1">MTMPQNLIRLKGAVQEYDWGKEGSQSMVAHLAPNAIGEEFELEESKSYAEASMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDZ9</accession>
    <name>A0A2R6NDZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v13523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001347">
        <property type="protein sequence ID" value="PSR70585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NDZ9"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="9">
        <location>
            <begin position="128"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="10">
        <location>
            <begin position="923"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1136"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1211"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1311"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1141"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1173"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1257"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1322"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR70585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1346" mass="149211" checksum="3705C7036D077A4D" modified="2018-06-20" version="1">MIQICRAEDGQLFEVRLKLGEIEATLLNYLQVDISIWDIDSLEHFIQKETGIEEDSILAYLSDGRRLMTENIRDLAGVQDQTIYVFNKTSLDLDLDLVLRRLRVVAPLQPSVEDTIVATPPFRPSYLASSYLRTANIHHDEVNGILRSLRYQHEALRIASTSLDLHVLAIQDAFEAIALGAQRELDKQESLLLGVDADLQIVSRVAIHKEFVSPAVRKAMELGERGRTLGDYVSHVKMRQVADACAKTHDDLRDRLRQAQDAMTRLRDGTDNVRTVVSDLSSLEDAQICARRSHDISTKIGDLAAALDKPASHSDRLVQDIRQLDASLRAEVESITQLKNSYTERCISALRETSVLNNYVVQLPSTLTSLQASFKAKTSFSHIQRLHNMLYAYGATVVEIVRRKEFAQFFYQRAQSILEVMAKLSANERKRRQVYRGEVHGQLPFDTKGMEGAVPAIDFSPSGSTDSPYDLQRTDVDDLMHVLEDLEHFARELTDPAAKSSIQEARASLEKLISKMDSLEAGFDRIAERSLLSSSRFLEHRRRSTEADEQAYSDLEHQLVQVSQAKTDQETKFDKERSTLLEELNRLREQVEDTDSSRDRMERDLHALKAQLESEATSRRISEQRNDEISSESGNIRKALADALSEATEQTKTAEILRQELAQVRAEFEAVKSLEQRNADKINNLLEEQANALRRLDEARSRGENLESQIQAARRESDDVKQALAEARKDKDRLLRAQASEHDRIMRDHIAEADGDRAVLEHQYLELKAALEDAQRQLKDARAQADMTNSDAVGLREELQRVEHEIREARHVERVLRDDIRAGRASQSDFEQRLESSSRLVAQILDVALAFRESHVKALKAAEAMTSHPPSKSVAGSSSMTESAFGGLRRSAVGYLGEPTPIDPSDPAAALEALRAFDHDQFMEAISKTGQTIRKWQKQCKDYREKAKGKISFRNFAKGDLALFLPTRNSVAKPWAAFNVSFPHYFLKATGHLEEQLKTREWIVARITSITEGVVDQKDASTNPYGLGDGVKYYMLEVEDWTQPSHTPKRRTPKKALSMLSHSEPPTTVTTPEPTPGPPDPDPEVEEPFPSRSPTSHLLSSRARGNSLPSARPSSLSRLLAQAPVETPVEIETIVPSRAHSPPPPTPSTPHPPPSPVRTTPTPQIGTAPLPLRSGSRASRISSSSRFSAGRIPFGTTGNAKAVATTALAAEQGVSASPSSVGSFNSPKSGSLSVSPEASPTEGLSNLLPHHRRRTSSYHPTRNSPLIGTVNLPSTSETSATVFNGVDGASNSAVAGLTARHRLASLASSWGVPFGRKKPSEPTASGSSGTLSRATVSQERILQKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE90</accession>
    <name>A0A2R6NE90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE90"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="16218" checksum="67C57DFB3D3F642E" modified="2018-06-20" version="1">MPQGSGPKQSTNRTSKFPESLRSSSRDAVKFVQNMHSWDPVEREEERLNCMLDIFYYDPTDAQKPAGSVAYCMTTRYLKLIPKLWETVWKQRMIFLARTNANSEYYTHIEVDPGEVITLLKIITILVEEYISHHHRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE93</accession>
    <name>A0A2R6NE93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE93"/>
    <dbReference type="STRING" id="98765.A0A2R6NE93"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF397">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015337996" evidence="4">
        <location>
            <begin position="20"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="198"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="681" mass="73851" checksum="C100D56A31E3E919" modified="2018-06-20" version="1">MKLLPLILSSLFITTLAQARERPLARRNTPSKRVTRQKHDFHPESNPAPLKQDTSPAPSASDIWDIFQRVNPPPPSFVQNPLYDPQQKQSPHQAQNWYNPLAAIAKRQASTDPTTDHVPMARVVVPTVSVVMVRSTAETVLEPNAAAGEESCALNVCCSKFGFCGSTDEFCVDECADDPSGHCGKVSVPTNAGASVLSRVIGYYESWAATRPCSAWFPQNVPADGYTHLNFAFAGIDPDSSQIVPGDTNDPSYYSSFTGLKKINLNLKTYISVGGWAFNDPPTQRVFSTVAGDVGKSQTFANSAVAFMIQYGFDGVDIGLTFTAPSSYWYLQHFDLQNLLKYADWINLMSYDLHGTWDAKDAYIGNIVGAHTNLTEIDQSLQLFMRAGVPLNKIVLGLGFYGRSFELSDANCAAPGCPYENLFSKIGHASYLFSVSTVPRLQDHVPQQLVSCLGINVNQWVSYDDADTFKQKIDYANGGGLGGVMVWAADQDDFAGSALSAILGQPVGTAIPAPDGFGSNDAQSCTVMDCGVACPSGFVQPILTVAAKPEVVRFVAQQEINLKTVNGAAQVCQVGEISLAGDSFLLQIWYAVDHILLLESALTLAYSGLTDAQLEMGQSYWGDWKQKWYDIFGTGACPGNAVTAPFTLDELFDNPPEDEDMSYKLQTETINDDNPDAGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEY9</accession>
    <name>A0A2R6NEY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001300">
        <property type="protein sequence ID" value="PSR70954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEY9"/>
    <dbReference type="STRING" id="98765.A0A2R6NEY9"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="254" mass="27129" checksum="A24B88695E3F0126" modified="2018-06-20" version="1">MSTSTQERPLAGKVALVTGSSRSIGASIAKRLAADGADVIINYHRIAVEAERTAYFINSRDGGRAFIVKADVSTISGGDYLLQECVRHLGAPDILVLNAGYMGHRPLAETDEADFDLNFDTNVKGPLFMVQAAAEIMKPGSRIVFLSTSLTKASTVLPLAIIYTMCKGAIEQIVRVLSKDLGARGITVNAISPSAVDTPLFRAGKPPQMIKWIASLNPQNRIPVPDEISPIVAFLAREEAGWINGQIIGVNGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF42</accession>
    <name>A0A2R6NF42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001297">
        <property type="protein sequence ID" value="PSR71004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF42"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="7497" checksum="34CC006D4D8C851B" modified="2018-06-20" version="1">MRAVTTPPIIVPLEVEDVDRPAEELEAEGVVDLANVLLVAGVVDGVLSGTSGGAEDADNKDGAGPGTVASSPDDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF45</accession>
    <name>A0A2R6NF45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001297">
        <property type="protein sequence ID" value="PSR71007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF45"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="303" mass="32056" checksum="2E1600B31574A785" modified="2018-06-20" version="1">MVDTAIVDDSNLGRLSYTGTWQDGGAAPFEWDGTTHGSQTTGSQVTFQFNGGSLLIWLNDTSFLIPLSGTQVEVYGTIGPTGDVLPTSTYLLDSASILTYVAANVSATTYQNQFYQSPVLQDGSHTLVITVTSQGYYWLDYLLYTPSSNNLASAPISSSSSLSSSSSTSSALSATSSAGSAASSTSSCPHANGSQSSSIPVGAIAGGVVGGFILGALLIAGLLYCWKRNPTGTSKENRGALESPGKSLYPIDNFVWTPKQSILQNFGHCQQTHKLRPLSLILIPQKSIRQPRQDLYQHTIPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFC8</accession>
    <name>A0A2R6NFC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFC8"/>
    <dbReference type="STRING" id="98765.A0A2R6NFC8"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="64106" checksum="D967236BD278502B" modified="2018-06-20" version="1">MPKVSAANFIFHARWILLRGGRLALSVALLPGAVQVICLVVLYYFAAKIWCGKYCGVWEPAFPKAWTAFVLFLSIIPIFALLQLIWLLGVKAVVYFMDRRQGSRYQHANGSSGRGSIVFDSEEAQYMLLREGEGEDGPRTARPPSPTQASPRHKLWSRIPSIYKLLWWAQITLYSVLLFVGAWEVSHYENEGDIRYRPVLQKALAHKSRDPAGYAKGEKIYFAAAFYNNQDVLPYWSQTLLDVIAYLGTNNVFVSIVENNSDDHTADLLHELDNSLANLDVQRRILIGDQAVKKPDDMGWNNRIDFLSAIRNRALEPLVEHGGYDKVVFSNDIFIEPESLIELLETNDGQYDMACALDFGHFGAYDMWVLRDRVGRLAAGIWPYFFDMADYQAMKTESAVPVMTCWNGIVVFTADPVLPVHLRSNRTLSTEPLRRQPPSTHPLANTLAQSPALTPPLSFRSSPRGEGCFSSESFLLPYDMRRIMGLDRIYVNPRVITAYVWHFYVWHKWVLRQRIVKWFVELYDGAWMQYARMIVGDDDKVYTWDGIDCHPWWYGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFS8</accession>
    <name>A0A2R6NFS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFS8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="16783" checksum="931E2805157E24B3" modified="2018-06-20" version="1">MESLVKKLYPDVDLAQDLEYLHPPRTSAVYSGQNAPFVNRRAATPSAHRFRHTVDTDNSSSSDDEITTGKTLEDSFGAVALIDPGRPYYYGKSSALVLLQNVMDIKGEYNDAASTSSLPPSQPREVPMKRPEFWNNHPVSVPFKFDLVSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFX6</accession>
    <name>A0A2R6NFX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v13206</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02001304">
        <property type="protein sequence ID" value="PSR70892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFX6"/>
    <dbReference type="STRING" id="98765.A0A2R6NFX6"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR70892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14606" checksum="63E64D0CB1C562A8" modified="2018-06-20" version="1">MPLLELQTNAKLDDPKAFIKEFSEVVFVAYLQTLAAELLKTPLEYICVNYKYSEHLAFAGTFEPALLLSVASVEGLDAESNALHSQKLFGFFEKKLGVKDHRGYIVFVNPSKDFIGFHSTTAAKIFASKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGP0</accession>
    <name>A0A2R6NGP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001271">
        <property type="protein sequence ID" value="PSR71554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGP0"/>
    <dbReference type="STRING" id="98765.A0A2R6NGP0"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="341"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="759" mass="84674" checksum="0E753FD178CCCBBD" modified="2018-06-20" version="1">MQPGSSKHKQSPIESSPNTARPYSKVAAKEIRRNRGEIACAECRSSMLDMHKSGMHSTVSERFVVAAKDHLQKKISKMEERMRALEDALAIAQTAESTQPHPLLTTPLRFEDEKDLDSTPQQEDPVKPVIEDELSDSFGTLHIDDREKTMRFFGPSGGAENEHESAEVTRPDLHEDIGPLDLRALGLPIELDMFFESFPLAPIGIPVDPVREIIESFLPPWERAESLCRILLQHLSWMFQIVSYQQVIQELMAPIYSRTSRSHPYDPHDLALLLAVLAVGSLVDLSLPAYNEDAQRYYVLSRSSLALYPLMEGASLSTIKTLHLISIYNGMSGKESNLANTYTVLNLAGRLAQRMGLHIDPGNWGLKGKDAYDRRCYFWNLLQGDMWQSLGTGRPPALADLYSNCKVPTELEEREYQQHEHAALGFGVWGFRLSRECVIPIIRIVLASGSPSYQLVIDLDQKIRSIAMPDGGDSPDSPSVAISMRWWVRSHYMELMLLSLHRGFFAQAIASYPTNPFDSPYKHSFVTAYKCACRVLDVTGEQFVRQPKLLSRVWMVWSFSFVSAVIVGAVASRAKHLDIDPPPLDSFNRACTLFQSASKVNSRAARALSVLLDMRERAMQLHYPSTEHRAAPAKDDDVAALRGKPRLVESTAQPHPAPPTAASGMPTTSFAPAPSTLAPAYPSSLQTAVPPLESNWHSGYSEPPVHQYHEQTLDPMPTVDESWVAPHPSYPESHSADFILDDTWSNFMQHYGSLGPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGQ7</accession>
    <name>A0A2R6NGQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001274">
        <property type="protein sequence ID" value="PSR71513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGQ7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="7860" checksum="98B782433AFEFA3C" modified="2018-06-20" version="1">MASTTPETQPEVTAAPQYCIAVPPALLQNAELRAIVELAAAQIVRDHAQMVLMDLENGNLRERAFAKERSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH44</accession>
    <name>A0A2R6NH44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH44"/>
    <dbReference type="STRING" id="98765.A0A2R6NH44"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="103"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="341" mass="38203" checksum="E31D2059229A8CF0" modified="2018-06-20" version="1">MSKFFKRITLSDYNTMLDLIYEGLSDESLPTGDTANLVSLSGLIVHNAPEASMKLTQAHTTRSLNIFADHPRFTKETSLRIQVLESVSSQFNERVRDHLPPLFHCFIQLMSLQPASIRQPDLSSTWSLLSSCLAGSTEHDSKTSASVYSKVVSIVSALIRMRRDLVSSTLPQLGIVIRRLILSLRHVRPHLGAKQRRMVTDSLPKWVNPDEPLSAEESKAVARLVTTLVTKTIVRTHSDTQKAESLARPFSKHAAYVLSAYIDALSDPLCFLPVDIRKELEPGLFALCDMMGEHNRDAMMAGTLDAGGKVVMKSLWREYEKQRYVHANINKDARLDTRCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHC2</accession>
    <name>A0A2R6NHC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHC2"/>
    <dbReference type="OrthoDB" id="2587968at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="200" mass="23071" checksum="391CA8B3438CCF04" modified="2018-06-20" version="1">MAAIRVWNNQPLRPAVNIVRRVVFGSETAVTIQELYKLALQQPYEGPKLNHVFRPSKAASDPKPPNPEHPIRSMSYLRNVILPELERRQCIEKVHEKRELAPEEIEIRKNKLSKAAQQNPQQYMTVSVWAWKRRSPRPVPKPKPVPEVFGKEVGVGDDISHLNRRRQNSRKDTVLREVAWLQELQKARREGAAASSKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHF2</accession>
    <name>A0A2R6NHF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001244">
        <property type="protein sequence ID" value="PSR71753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHF2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="109" mass="12719" checksum="9335D5578C8C24E3" modified="2018-06-20" version="1">MYYGRWYHKQSIWHPWRNVRRAYTRYSFAESISSKLEGSKKNQGIAISNANITSPRSASSRTISIAEFGLMTQQEFMANWQCKTHLPLPPRHPAYVFVHALRPGDVHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHV4</accession>
    <name>A0A2R6NHV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHV4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8070" checksum="CFDC71D067554F31" modified="2018-06-20" version="1">MLYEIAEYKTQEPIRSSTVEWFVESSTDVVNANLSKNGVTTSGRRERGNGIPYQLLATGVSNANQVDVWYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIH9</accession>
    <name>A0A2R6NIH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIH9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIH9"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="108"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="167" mass="17829" checksum="FFB137B6E93D3938" modified="2018-06-20" version="1">MATEFTVPFPEGYGATVHFFWPGKGFQLLGMLSNEKPSAIFRLRGNFTSQSSDKQAVFSGASTPVADVTPQGVTAILGLAIEPLSQIMQEIASLPSMVAPKSNPAADATLLAERIVKHLFNYLSGFASGGPLTPESAVPMGMIVKWYEAFISKVRNSGAAFLENQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJU1</accession>
    <name>A0A2R6NJU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v11518</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001151">
        <property type="protein sequence ID" value="PSR72634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NJU1"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="368"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="1091"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1416"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="19"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="212"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR72634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1773" mass="196859" checksum="5C1CBE0533BB1CB3" modified="2018-06-20" version="1">MDTTSLSSTLTLDHTDDFLSHQIFPEPPPAVDRAVAPWLDPPSPTESGPGAGPEPPTPPPKYRTTGFHKPSLSSIASTVSLRSASRASDVTSIGSGTTTLTDAPRYGSDTSIRKFKSGSSIVDAVLKKVRSRSRLRPEQLNFLSPTQDPVPPLPSPDAILYSHPPAQYLPPSTPRVKPHKRKTPDEPPPLPSKNPDYVFDLNIENMDGIVDLKTVPEIPSDAHNGEISSPSSGTHSSSLSSDVSSTYRNRPSIRARLPSSSHGVFRDPFAPVPPNSKRKAGPPAYDGRKISPKTRPLSGDSQLWKAPESWAVEPGNEDFGNAQEPTSTDDEDMLLTEGDPLVECPDVAKKKNLRKRRRSSLGKTINKPTYKFRIYRADSTYHVASIELSATVKQLMKYLNNKLLLDPDRETHRLYLKERGRERILSMTEKPANIVRKRLQEAGYEEADGLPSLGMDDIQFLMKFVYKSNVLGRTPQQEDILDNLEFVDLTARALTTVPVALYPHADAIVLLNLSRNPMLEIPLDFIQSCTSLRELRLSGMAMKKVPQSVRHCTTLHRLDLSCNRITDLDDAGLEDIPGLRTLKLQNNGMERLPWHFPRLRSLRELNISNNKFRQLPEVVCKIPSLIDLDISFNMISDLPEEIGNLEALEKLVMVGNHVARLPVRFGSLTSLRSLDCRRNNILNLATACLLPQVENVLADHNLVHALELSFGPSLLSLDVSNNDITQLTLLPGPDGRQFSLKCLDLSHAKLSSLDDLALSCLITLHTLRVDHNSIRALPDSIGELVQLRHLSCSNNQLYALPSTIGKLQKLEKLDAHNNSINELPKTIWQCASLCIINVTSNLLGTLHEPASLEISVSPPSNMSASPYMERKPSAAGSITNRTLPPLAYSLEKLYLGENRLTEDSLHPLMLLKELKALNLSFNDLQVIPPSFFKNLTCLEELYLSGNKLTALPTEDLPRLTSLKALYLNGNRLQSLPQELHKMQSLSILDVGSNNLKYNTNNWEFDWNWNFNSNLRYLNLSGNKRLEIKYDQKAAPLKDENGFEINLADFSHLHQLKVLGLMDVTTMFLPNIPDDNEDRRVRTSLSEVNKMAYGIADTLGGNLSMFDLVQPAFRERKNEAVFAMFGRASHIGSSNRVSKYLHDHFLCTFSEELEKVDEYLPENIHHALRRAFLKLNKFLHDFLYAPQRRKSSVVSASGHSTDAVDMSSVRSGASGVVLYFVDRTLYVANAGNALAVISRQGNAELLSRKHDPFDREETNRIRSAEGWISPKGYVNDEIDVSRSFGFYYLFPIVNARPDIVAWDLSELDEFVIIGNRGLWEFVSYQTAVDIARTVRGDPMIAAQKLRDFAISYGAEGTTMIMVISVAELFGGGPSSSRQPTTDLVDPEVFPVRRPDPTGDRGIARLDEEVPAPQGHLALVFTDIRNSTHLWECNAGMSHAINSHNLCLRRRLRLCGGYEVKTEGDAFICSFPNTMAALWWCLAVQIDLLNVAWPLEILECEDGKEIVDSAGRLIARGLSVRMGIHCGSPISDPDPTTHRMDYLGPVVNRAARISSSAGGGQIMCSADVIREVNASILVTEPPTEHTHEQPAKAVDAIRHIGVRIIPVGEVKLKGLEVPESLSLVYPAELAGRHDLETLQTNSDASGSRVQFSVEQMRELAMLCLRLETLTSSRVFRPLPRRKGSTANPVEDEALDANPVFLYGNPDVLLPTIDKASDTELMLLLDQLSMRIENALTALAVKQIVSLNKGDRSTRRTGAGFDVRTLQQLLSFLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJZ8</accession>
    <name>A0A2R6NJZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJZ8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6004" checksum="A317787C75694F2E" modified="2018-06-20" version="1">MAGEGGNEAAPSDVDSCGTAEQKTRWSDGGDEGQQHANNFGTIKSVMSLVFLQMGNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKH2</accession>
    <name>A0A2R6NKH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKH2"/>
    <dbReference type="STRING" id="98765.A0A2R6NKH2"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="12455" checksum="3BF316C7BEF3A483" modified="2018-06-20" version="1">MATIDSNHLSAFPDLALQLLEESLELNKPDDPILSSLSSPEARQFTTDRECTRRCFWLIQCMGWINGIYTYRPMRPRSVELMRQVRLPVDETSFELAKITQEPGKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL53</accession>
    <name>A0A2R6NL53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001105">
        <property type="protein sequence ID" value="PSR73119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL53"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6048" checksum="6746B265EBB6392F" modified="2018-06-20" version="1">MPAGPNLAPGRYERTDKWCSNESNVEGRILIPSQALYPGELGKSSYTGEYRVSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLH5</accession>
    <name>A0A2R6NLH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLH5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="16068" checksum="B456954DF5DB2646" modified="2018-06-20" version="1">MGAYQRAVSNDIKPYGALALAATAVERAFTASAGGYVNRTHSWFSDRNWGEVSMKYLAATQTLSDATWNIIVRRAKATMDQAEPDQFKILKDLPEKPVDDYAVDDIVDEEWLANNREGDEAEDDGGVREGGNVHDEHMKVEEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLY0</accession>
    <name>A0A2R6NLY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001082">
        <property type="protein sequence ID" value="PSR73347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLY0"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="315" mass="36054" checksum="CFA1CF0CDCACAEF5" modified="2018-06-20" version="1">MHHEISSGTLSAPSWRLIRNAKLAARIYAPLGTEMSLGDYVRVVISFQEAFKLAEAPHIESSSDGEANLSDSGEALDARIISLGSSLKHYQDELVRWGVKDDRIRRPLRRRVIIYRMSVRLLWSIFLFSISFPGLFLWLPVFITTFIAVREFKRTGPIWDTWDEIAQYKLVYGLISGICVWAGAVLLTFPIAPISAVAVPIIMWTSLRWLEDAVSAFRAFAALARLLWMGRARMLKLQVERSDLHGGVMDLAINTIGLPADPEKFFAETGRKEKGRVRGKWASSAKYFSLRRRRKRDWNETLRLYDKVDYPDDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLY7</accession>
    <name>A0A2R6NLY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLY7"/>
    <dbReference type="STRING" id="98765.A0A2R6NLY7"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35828" checksum="E9FEB5C8D59D9B3B" modified="2018-06-20" version="1">MSHSKYSDSLYKFHSTGGNKLYDTVTHKDDDPPPPYNGVIDSKVDDLLERLGQEFSELYENPVEILEMFDTVVLLDDSSSMKHIDGKDGQSRWEKAQIALAAIAEFASRYDDDGIDIHFMNTVLKDGIGMNLKSRREVLDLFSLADPHGGTYLGKRIDGLLVKYLKSLPPPEKPEKPETEKRKKSRWTWGKSTSRVGTSTSGAPAIKRLNLIVITDGLSYDSLKDPIVKAAKALDASMKPLDQVGIQFVQIGNDKNAAQALQELDDDLRKEEGLRDIVDTTPYDANKDGGGDELNAEQLIKMLLGGVNRGCDEKGAAHFGIGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMH0</accession>
    <name>A0A2R6NMH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMH0"/>
    <dbReference type="STRING" id="98765.A0A2R6NMH0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13826" checksum="E7D52D38DA8E918A" modified="2018-06-20" version="1">MHKAYSQERALRKEKDHHWDNLLDNPYQPSPVPYSSRLFKVISSSPPSLPLESQDRERSREYRACRLRIGRGGRRLLDRRVLGTHPTPSQTTTRGVPTMKVVGNWRNDGGLMTTMSQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN60</accession>
    <name>A0A2R6NN60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v10390</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN60"/>
    <dbReference type="STRING" id="98765.A0A2R6NN60"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="47"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR73820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="363" mass="39535" checksum="249731324D62A3DC" modified="2018-06-20" version="1">MASTKWSRNNTALCRTIRAGYIAKFSTSSLSQANRAVVYKSTGDPSTVLSVLTFPSLPPPESHSVNIRFLLSPINPADINVVEGVYPAKPVHNHSLGGRALNEPVFVGGNEGLAEVTAIGSVVKDIQIGDRVIMATPQLGTWASARSVAAGDVIKAPAGVSRVHSATLTVGQTVIQIAKLKGLNTLNFVRHRDDVESLKSHLVDLGATQVLTYDELEDKSIRDRVKQWTGGKQIQLMLNCVSGPSTTAMIRLLGKDAHVVSYGAMSKKPLSIPTSAFIFKNLTCHGFWQSRWYEQKTRVEREEMLRKLADIMGNLREPEHEIQTIPAGESDVDATTRIQGIIKKIAGGQYGKKVLLEMEEPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN92</accession>
    <name>A0A2R6NN92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001053">
        <property type="protein sequence ID" value="PSR73865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN92"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="423"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="913" mass="101935" checksum="051BD8E1ED1871FE" modified="2018-06-20" version="1">MSVPTPTTAAEATPQPRRKGARLTRERTVYIMNTSHIQISSRVKATVHPYVKQDLANAKYIALYAWTETVLGLSQKDLEERAAHIRQLKWFEDTEIRQAMVAFCTTPHGESHEKGRYGPFAAIVNRAFELAKGNLPGVPNSYPIDDICVVRNDPHDILCIPEHGKLGAERSPDLLFLRAEPARKLLASKAKRVRWIDVLGWIEFKASKKNLLRILNDRRKEYGLGVIDEGTWESRESTPEPYLDLALDGAEIETSVVPTVGRKHARDVEDDENDYSDPTGGPSSGSSAKKLKTTHSPTDGRTDAKIQSGGYALETAACTYGTRSFCIGIVFDNDKMSLWFYDAAGYISITTTLSLLADFEKVLSIFVGFACLGPEGWGAMPSVLSPPSQSPAHFPRASLENHTFTLPRKGRSNVRVTLTKPVFTQYSLVGRRTFVYDIRTSSVVSKEPLVVKLSYQVASRKAEQDLLALAKKAKVEHLPEVHLWGDLWKMSDGIRQIFYDRSSAMSANEDEIASYEDRTLRALVCTKYLPLKGLFAKSWKMIPEMVFQMLDCLHDLRYKAHILHRDLSCNNVMYEVRNGKVCFILNDFDLATVVTDEGEPSAVASSKHRTGTLPFMAYELLKDMTRSNKNGSGPRVMHRLRHELESLLYVTVWSTVATPDAEGKKTEFVDYLRTWEMGTVKSVEKLKWSLCSDPDEVNDIPLPLAVEPLREVFIRWFAILRRAYTKWNEIRYPEESQVSISLQEDFDVETLDGMITRDTVYKAVTEGLVAAGLAECIRTKASDGAILNAENDSREAKANGNKSSGNKANSAIPVNTSNRFPTRATKYVQPKPKAPKAPDPQKSRADKSSQRIPSTTANRGSINASNTSTTKNVDVAKKTVARRIPKAPKSTTTATRTMTTRSMMKTLTSTAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNI5</accession>
    <name>A0A2R6NNI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001037">
        <property type="protein sequence ID" value="PSR73987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNI5"/>
    <dbReference type="STRING" id="98765.A0A2R6NNI5"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="370" mass="42199" checksum="A1963516473E7185" modified="2018-06-20" version="1">MATNNMNMDGMMLFEQPFARVPYENYRKVFRTSQKNIEKELSALQTTANDLMKRARAGEGSPEEALKAVEGMIKRTEILKRKLAELQNASGLPTLSVTRERLEHLSTVESITSANGPEFARWADTRLDRWLVDWALRNGKEKTARSIARERGIETLVDIDLFSDIRRIENALTRQSCTEALAWCSENKAALRKVKNPLEFDLRLQEFIELSRIRNLMEAIAYQKKHLIQWQDTHSAQINQAAALLAYTPATAFGPYKRLYDTARWTSLVQSFRLAIYNLSTLPTEPLLHLTMYAGLASLKLPACYDHETKNVDCPVCDDSFGALAKEVPFSHHVNSTIVCRLTGRIMDDDNWPMAFPENGHVYSKEAREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNV2</accession>
    <name>A0A2R6NNV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNV2"/>
    <dbReference type="OrthoDB" id="2751365at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="306" mass="33673" checksum="6C4AC4E93288B4E0" modified="2018-06-20" version="1">MKYSSIGSQRNGQDALNCVQCTDNLSSVLTIIRNHQAPHRIKNICVELTSSSEDDQHASDLFIVTAKCCKNLEAIMLDGLWHPGRPITIGFKAFAPLLQCNKLTSLNISTSGTVNISEDQLRTLLSSWPSLRQLILDRAGTIPLDPVAKLPLGAVVLSLLEHCRELEAVALYVAPVLASPQKPIQKISSPRKGYKISSHYSLKALSSRLSSLKQVRFHIGWGTTSLAPPSEVALYLKHLLPPDCGLVLDGDVTGQEKWCEETVASWKRIVTEGPFLSEEMACPVLDCYTEQLAIEKSDILNSPRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP45</accession>
    <name>A0A2R6NP45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP45"/>
    <dbReference type="STRING" id="98765.A0A2R6NP45"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="291"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="593" mass="64106" checksum="C72EC6669F7AB363" modified="2018-06-20" version="1">MSLIPMVEKEGLLSNSLSQPTRKSTGPLKTSIYVLLALICTGTALYSVQPHFFCGGHVGTAGGDICPQPGVLVPSKNGALWKGLVEETYNSQEFHDRAVNWLGGAVRVPTESFDRMLPVGEDPRWDVFGPFHDYLLTAFPLIHTTLELTKVNTYGLVYVWKGSDETQKPLLLAAHQDVVPVNPETADVWTHPPYSGYFDGERIWGRGSWDDKSGLIGIMTTIETLLENGFKPTRSVVLAFGFDEEASGLHGASAIGKYLLETYGENAFAMLVDEGGDYMVEYGKVYATVGTAEKGYLDTRVEVASPGGHSSVPPPHTSIGILSSLLVHIEANPFVAHLGRGTPMYLKSQCLAAHAPGLPRSLRKSLTDAARSDKALRKAEEALFADPRFKALVGTTQAIDLVQGGVKTNALPESAWAVVDHRVATDSSIEDVQKHETELLKHLASAFNLSYTAFGKQISEPGVPAYGTLTIDEAWGAALAPAPVTPSSGDAAAPFNLLAGTVKATYEAHRNISDGNGDGVVVSPGIMSGNTDTRHYWRLTEHIFRYSHHYTGNQTWVAGGAHTVNEAIYVDSWLEQIRFITTLILNADESTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ77</accession>
    <name>A0A2R6NQ77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000963">
        <property type="protein sequence ID" value="PSR74700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ77"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ77"/>
    <dbReference type="OrthoDB" id="2798752at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="28476" checksum="86CEDDD37D78105D" modified="2018-06-20" version="1" fragment="single">TSSTLPDSTWSPYPNESSFRLGEWYWNDGTCKSQASFKKLVNVITAPDFSTEDIQKTKWDVVDRELVLERDETWDGWEDVDGLGWVESPVTISVPFHKNTAHPGTQYYTLPDNFRHRRLLSALREKVQSADFRHFHTHPYELHWKYGDASDDRVHGELYWSDAFLEAHKSIQAQPSEPGCKLEKVVAGFMFASDATHLTAFGDASLWPLYLAFGNESKYRRSKPSCYAQSHIGYFRKVSGSLSVVPTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQZ3</accession>
    <name>A0A2R6NQZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQZ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NQZ3"/>
    <dbReference type="OrthoDB" id="3258638at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="177" mass="20300" checksum="0851F0ECC62A1DEA" modified="2018-06-20" version="1">MSILPQAYVLILRQLTPLIYPTILVIASFSFLRRLLNVVVPTWIVVIAVLISMPSFMITRAQIFHWLNARRAARLGAVLPPRWNGKRIGNLDVLEVLRKINVDGYLSDNFWEKMHELGPTYEVSIMWDPDYVTSDVNIIKNVLATDFNNWVKGEKFDAFMKSVLGTGVFNSDGDMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRN8</accession>
    <name>A0A2R6NRN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRN8"/>
    <dbReference type="STRING" id="98765.A0A2R6NRN8"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="651" mass="75723" checksum="6511954CA9F39CC9" modified="2018-06-20" version="1">MLPIEASDNYKPHHERPSSDEPDMDEPEVERRPRKRRKKDLSKLPDMPLDILFEIFGNLHPLDLLRLARTTKALRDILMSRSSITIWREARNNVERLPDCPADLSEVAYANLAFDPHCHLTITLTARFLDWSGTQWFDALEGLDLQKVLPSILRSDKYWYRRDQIVQLTGIIEDFPAGEEEAMAFYNSRVAWVKEMQDSEVALTAWQEDQSQQRSQELDDLRLQRRKQIMERLAECGLADEVGLMDDDNFEAFITQSWMKQPKALTTRTWNNIKDSVIEYVLEVQSYRIANERLRVPSDRIETIAGILDQYARTRPTTEYLPSLPDICVSPEFIRWLTIEAPQVVGFTSTGIMQKLPEICAHWRKTASFELLEIMGPSEKAAPGYNEADELKRLDLATTFFKCVTECCYHGTIAYPRILVHPCAAPLSTFFNKPNSDVYDVLNALDVLGLRFPWNFSRDTIEFDWVAWDAAREIVTLCGGDPEKTTAMQMDALDRRLACKQCKTAMNWRKAVSLFLPQLNADSKLRQLICLRFCPFTKVYHSLSYTHMHSYRYVEPAQWRVLDQDRTDLVLQKEAERSEQAKRCWAKWCCTRCRTISGGRRMDWGSLKLHLVQDHGFEEGLRKGRDYYMHPDIESSEMDGPDEVHFQSRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRS8</accession>
    <name>A0A2R6NRS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRS8"/>
    <dbReference type="STRING" id="98765.A0A2R6NRS8"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="381" mass="42626" checksum="FEA321C5A1C34BCB" modified="2018-06-20" version="1">MGRSRPKNRKTQPVVTESITISENSQAPSVSALLEKTQALIVQCDYNLANKFVRRVLERDSNNAEAKEMLGVIQLEIGELEAAKQTFLTLIPPNPSAPSPPPPSAYLYLAQLSDDNPQEALQYYQSAVDIQMAQLKGKERAAGTTASDDDDAELRRNIVRALIGMVEIWMDPSYDLCFDPAAEKTCEDLLNAALQTDSGNTEALQALASVRLSQQRPEEAKQCLEQAWTAWKDFESDDIRLPPIPTRLALVKMFLELELYEPALLVLSGIMAFDDQEVEAWYLEGWCFFLMAEHAQEHGGIFNELTWEQLARDARDCLEMCKTLHLSQEHPDVPLLDHVRELISKLESLGVQPSPEDGDEEGEGWEDVEGSDEEDGDVDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRZ0</accession>
    <name>A0A2R6NRZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRZ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NRZ0"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="17029" checksum="B8C1D94A03695540" modified="2018-06-20" version="1">MNWIEQDSLLLEGSDMDIQAREVKRRDYQNWPRARTIRKSTLAPKDNLDYAADDVPNCASPRGYQHTLQTGPAWSFSREDKTIWKQHFIRVKVTTRAIKTIKKHGGIDNYVMKTKPELLGWEGMRIRVQVRERKALNAQAAVEAPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS44</accession>
    <name>A0A2R6NS44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS44"/>
    <dbReference type="OrthoDB" id="3208773at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015302263" evidence="1">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="173" mass="17897" checksum="8966C446525A67C1" modified="2018-06-20" version="1">MVHFSFSAALALSLLVAAQARNVARSPSYAFLPASDLHRRTTGQTVAFACYGGGGDCECPIDKNNDSGALINVYPGYQCAYPNGACTWDDKTGALQNTAQTNCPSTAACSTTGGCSCPKDNLGDSGVLINQFSGYQCAYPGGACTWDYGGELQNTAQTNCPTNAKCVQSGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS98</accession>
    <name>A0A2R6NS98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000880">
        <property type="protein sequence ID" value="PSR75733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS98"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="400"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="868" mass="98053" checksum="3B60B45B3CF86512" modified="2018-06-20" version="1">MRSSGDVVRGHNTHSVNSFVEQDLWQNLQEVPLETWIEAVLGLSPRLLNQWTARIKKLDWFQDRVIRRALVDYARPTVAEESDIYKPFARITNRILELAKGTLPGVGDIYPIEDIKVVVNGSTQVECIPEHGRLGVCCQPDLLFVRGAQNNLSSDIESPARWVDVLAFLEFKLVNKGLLIQTLNKCRNGRGLPMINMESRKSRNRSKRSAAKRATKRHTAHAFKASQVPAHKGSSRLSSVSSKRSFDDMLEGEFDQSQGSSKKRKSDSLGSERIGKGVRLLAAGNALELASCTYGTRVFSLGSIVRDDKMSFWYYDASGYVRTAESLSLMEDFEKFAAIMVAFACGHPKHWGALPDIISPPTSTPYPSSFPPPSLKGHSIQMTLPDTKERVKVTLGKPIFTQYGLVGRRTFLYQIKTNTVVAQTPLVIKFSYQVVTRKREQDLVEVARKAGVKHIPKVHMWRDLWKLSEGARAIFHGDNKDAYEDRMLRALVYTRYLPLKALFRTAWHLIPHMADQILDCLHDLRYKANILHQDISNNNIMFEIQDGAVNFVLIDFDMATTVDSSGEPLATPSAKHGTGTLPFMAYELLHDMAQLESTSSEHQRIVHRLRHDFESLLYLCLYCLFTMVEVEDAKIKADMAKQLREWEDQAYNSIASAKLYLCTDAQGMGQLALPTPCEILRPWFYGWVKVFQRAHSAMTSYKNQIEWAQWYKDESSSSFDIDTLQGTLTRDKIKQSLGFFYDRPLAPEDLQVANIPGLGKQIEAYMHDDEDLAGQDRHVQERSAVSEKANPTRKPRNTTKRVEVAKKKTVPKTVVASKKTTTAKLVVSPVRKQIQKQAEPKRGVRTLAATTRSMATRSMQKGALAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSI6</accession>
    <name>A0A2R6NSI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSI6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="12191" checksum="60BFC767472301BB" modified="2018-06-20" version="1">MTSNMSAVSAISSVMAVEGVSGEIATPAFIFFSWIAWMRDRGSAVVTCQLQTYMVAGDLKKMITCGFQVEGIEGTSCLRDVVYPLQSASDIIGEAWHGRYTPSRAVRPSYGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT53</accession>
    <name>A0A2R6NT53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT53"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015363181" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7343" checksum="F161A2B9A399310A" modified="2018-06-20" version="1">MKRVKLSTSVLIWAITQSHAFSWTKIRQDESLAQARSSPIRDDVWSSGELAVILNAGKAKIVSFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTA2</accession>
    <name>A0A2R6NTA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTA2"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17449" checksum="9C68D59CC82F6C22" modified="2018-06-20" version="1">MVRLLLSLKAELENVTNLVPASDDFEYFFQVKCTSCQEVHPKFVGINRLEEHEVSGGKANTAHFVWRCSYCKRESSAKFEGKSPTIPYSADANSQFAPFLTIECRGLEFIGFDPTRGVWKCAGIESGTAFLEVDLSEGEWVDYDERYTMSSQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTP8</accession>
    <name>A0A2R6NTP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000861">
        <property type="protein sequence ID" value="PSR76117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTP8"/>
    <dbReference type="STRING" id="98765.A0A2R6NTP8"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00385">
        <property type="entry name" value="Isoprenoid_Biosyn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="520" mass="57350" checksum="B7AA95D53706473C" modified="2018-06-20" version="1">MVAARSMRNFERNAQSGTGNAWCIVDSPTLGRMSGVSRRLEAVPKSEKPATPSGSCLAINIAPLNIKKIRRRGLVSGVHLTLPPSPLPTGSPKHSPPETALTFTAEWDLTENTFVFTPFESSYPPSSVSSQFSRSPVPVNVDEDTVSRSASLISPSVYSSMLSPHPAFTPSRPSYVGDDRMAPNRPESIKGNDSAASSHGTPVSSIFDRNSMYSHSRQLSQSTVASSVLEDPSKCGQATSSVPITRETALHTFKQELHRAVPEPDDKSDFDRGVVDEMDQDLLMAPMHAFEKTLWESTESDAQALRRSVVDQVATVFPNAARRERPLPDVPRSASTDSVYSSTALLEPFSHINSIPGKDIRGQMLAAFNAWLKVPDDKLRTITKVVSKLHTASLIDYVPLVNLWGVYFQIRDDYMNLQSSEYESNKGFAEDLTEGKFSFPIVHGVRADTSNRQILNVLQKRPSTPTLKKHTISYLQKHTKSFDYTLSVMASLENQIYEEIARLGGNRGLEEIMKALHVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTZ3</accession>
    <name>A0A2R6NTZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v8558</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000851">
        <property type="protein sequence ID" value="PSR76264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTZ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NTZ3"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="371"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR76264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="446" mass="48858" checksum="31E68619E8B196CD" modified="2018-06-20" version="1">MASTTEVAAAKYDLITRRLQEVLGGDSIKAILTEGKRSPKCYWGTAPTGRPHIGYFVPLTKIADFLRAGVEVTILLADVHAFLDNLKAPLELVAHRTKYYKFILLAVFKSLGIPTSKLRFVEGSSYQLTKEYNLDNYRLCSIVTEHDAKKAGAEVVKQVESPLLSGLLYPGLQALDEQYLDCDFQFGGVDQRKIFTFAELYLPRLGYAKRAHLMNPMVPGLGGGKMSSSDPNSKIDFLDPPAVVRKKIKSAFCEEGNVADNGVLSFVSAVLIPISQLRIERRHGDTGADSEEGQEALGDQSPFALEGAPEGTVFSIYRKEDFGGSLHYSTFKELEDDFENKKLHPMDLKTAVADAIVKLLDPIRKAFEESEEWKTTEKLAYPDPNAKPEKKKKVKVYTPPPPGKGKNAQQAATKTSATPPVPVPPPGDDTIQAAVEAAKEGEVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUA8</accession>
    <name>A0A2R6NUA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000835">
        <property type="protein sequence ID" value="PSR76760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUA8"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="55"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR76760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="346" mass="37782" checksum="D35617BE7902DB94" modified="2018-06-20" version="1">MSAQSTEKDYERGIDGDEEERSQMLEVSLEKGNIDLPSPVSATQTRPTNKPRLSTAVIIPIWIVLSSSVIIYNNYLYNTLQFRFPVFLVTFHLTFAAIGTRVLQRTTHLVDGAKDVHVSKEMFLRSILPIGLLFSGSLILSNTAYLYLSVAYIQMLKAFTPVAILLISWTFRIQEPSKKLAVIVFMISSGVALASKGELRFNLVGFITQAAAVAFEASRLVMIQILLHGLKMDPLVSLHYYAPVCALINLAILPLTEGLAPFYEVMRIGPMILFSNALVAFLLNVAAVFLVSSGSGLVLTLAGVFKDILLITGSVLIFGSSIMPLQILGYSIALGGLVLFKTTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUG3</accession>
    <name>A0A2R6NUG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyaluronan-mediated motility receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUG3"/>
    <dbReference type="STRING" id="98765.A0A2R6NUG3"/>
    <dbReference type="OrthoDB" id="419631at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="79725" checksum="BCA7F7685ED2192D" modified="2018-06-20" version="1">MFGRGNRFPAAKHPEFDAYKHGAFLEKQDRFTKEKPSEVPGPGAYNMEQKTTTSKSGTGTRIASGDRYALLQRKVEELERLHAENKKNHLAEVERLKLELSRAQATHAEQTGRNDKLKKQNDALDTRVQELKRINLSDQSEIKDLRAKLRVSEHERTQLAAKQGETGEAKKALQSLDAKRRDEVRERDKKISELEKALALEKKRKDGLEVRLSEIKGKVGAEVQEARAAALTLESELQETKLESEKAKFALANLKSQAEDAEGELLSQLEQHRLVLSRVAEEYGRLASSTVSTAEYERTKHESISLQFRILRLERKLANAEDQVVEVANLVRATKEDNTILSKQLRDVAEEAMFYSSALSDLLEERIPDPTSMRVVEEAMTSLRRNIEDSRLAVQAFSSQDRASWAEFDHMRTEQLLLHSSFLVKHLDEAQALAEQQRARLADAENRQSQLAAELSTASFRHDTIQVQLVEATASLAMAKVAEEMLKKEAEEAQKRSKAEVARLEGAVKQERETSQRLASAVQQGKAAEEALNAEIDQLATDLAEAERYQEAYTNLVEEVDSLISRNALAEEEAHRLSKFNAEILGHHNPAQRIMYVDKIRRELHDTKQQLLISTRDRDTVLDENDDLRNELELYKSVAVPLNSKPRTTVTRVTRMPLTNQSMNTSANTRGLAHTKSTNNLVKRLETTPELEYKEGDMTVEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUT0</accession>
    <name>A0A2R6NUT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tip elongation aberrant protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUT0"/>
    <dbReference type="STRING" id="98765.A0A2R6NUT0"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1116"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR76700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1231" mass="135224" checksum="8E6EEE9A3A6338EE" modified="2018-06-20" version="1">MSFFSRKKHAPPPANNVQVQQTPSAALAQIQQQQPPQQQKPVGKETSYESGLNGRGSPSVAPNPSQYNSTQPQQRQPRVGSPSTLASNTNGSAQPSPLQAQTPPQPSQTQQPQPVQQGQPPQQPRSAYPWSQRRLTLPAPVTLPKHGVAPPTTPSPSPFPRYGHALPATATTTGELFLFGGLVRETVRNDLYLFSARDLTATLLQTAGEIPSPRVGHASALVGSVLIVWGGDTKTNNKTKPADKQDDGLYLLNLVSREWTRVAVYGPGPAGRYGHAVTMIGSKFFMFGGQVDGEFLNDLWAFDLNSLRTRASWELIEPAEGSPRPAQRTGHICVSYGDKIVLFGGTDCQYHYNDTWVFDTNTRVWSELTCIGFIPSPREGHAAALVDDVVYIFGGRGVDGKDLGDLGAFKLSNQRWYMFQKMGPSPTARSGHAMASMGSRVFVLGGLGGESLNPAKPEDPTLIHVLDTKHIKYPGTNGSPPIGPPTAPSRKSSVTAPAQVVNGVRAMSPSGDQGADPEDLRRAISPSSIRSTSKPNGIPQSINNSLKGKNPLQATREDEEYDSENPDIISGERAMSPEQNRAKSPNAFSSNRAMSPISQNGGESYEPLSMTGVAIAAIGVNGTSRSASPAVVEPRGKLSMDGGYSHKQGSPSLNGFMSKGSTGNITADLIRDLKEKEAEIEAIKKRETWMKAALSKASRAGFIYADAEDLGSDAEDDDIDSRRVSEMVINLKHVKAKLQVTVAEHARLASERMEEAEKLRSSAIQEASFYRAKLAAIEASSDRDISRLERERIGDLERQLASLASAQAEGDRQVKELQESLSLQTTLLEQAEARAEDASRRADMLAESHSQDGQDQSALHERHALMEATLREQADQLLSHKSQLEQREAELMSAQSHLEEMLRTRDQHVRALEQAQNAVKASSSRADELDLQCQRTRESARLLQSELFEKLGELESRNHELNSVREQLIDTENSWAKSREEADALRALTTGSLGELLDVHRDLKSDDDRAERNHAEKVSAMEDEIASLRSMLKDASRRAENAQNELTQEKRKMRDNDVENMALRSQILGLRTQLSSALADSGRLRKELAVKEAEVRERVKESSSVNSKLDALHTFLEERGVSEGDRDEGSSSSRVAELEDQLAGRDRMQERTERELQIAMQQKRDMEDRLDSLSAEIGRLQSSPTRRGSFDGDAEARVAELERKLEETETSYKARLQQLEEDYQLAVHYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUV3</accession>
    <name>A0A2R6NUV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000810">
        <property type="protein sequence ID" value="PSR77167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUV3"/>
    <dbReference type="STRING" id="98765.A0A2R6NUV3"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR77167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="464" mass="53111" checksum="ADD917BBE9FDDD44" modified="2018-06-20" version="1">MQEKFQKLFDDAPQVPYTVVRAVLRSEFGRDPSGPEGVFEEFEEQAVASASIAQVHRAKLRSPDGNGPWVAVKVQKPAVSKQVEWDLGAFRVVMWLYENYLFDMPAYFIVDFISDHLRRELDFELEAQNAIRTAKFVASEPRLADRVYIPKVFPEYTTKKVLVAEWIDGVRLSDHAGILKLMGETNRRGTTVQSRLPFPPKPLIGGVSSIMDTMLQLFSAQIFEWGWVHCDPHPGNIIIRPHPQKPTYPQLVLLDHGLYVRVSDEFRHQYATLWKGLMTMDFDAVKDVAEQWGIGTPDLFASATLMKPVSFKGEDARAEFIKLNQYERSVLLKERLKSFLTDTDKMPKALVFIGRNMRIVQGNNQMLGSPVNRIRITGSWASRSLAFNPDLSYRQRMREYVGYLGFLLATFTIDVLFWTSKVKQWVRYRLGKTAEGFEDELERTMKGFAKDNFGIEIADSAFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUX2</accession>
    <name>A0A2R6NUX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000805">
        <property type="protein sequence ID" value="PSR77235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUX2"/>
    <dbReference type="STRING" id="98765.A0A2R6NUX2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="18822" checksum="0F0EE52B5E42E7F4" modified="2018-06-20" version="1">MNERGTVAALGQEIAEAAQECCRTTLSLNNQSNFIQYYKQKYPDIDLLARTNPHAVEWSNFLNNQVVFHNYVILSGRQIKPSKFDEYAPNSLIQYESSGQKYVGKVAFIASHYQPMNDQDLLREFLFGVRWLKRASFQEFNTSTWDRLYLTIALIYVFSAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV98</accession>
    <name>A0A2R6NV98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NV98"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="86"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="281"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1154"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR77449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1540" mass="174940" checksum="FFCDDF683AF845B0" modified="2018-06-20" version="1">MAIESSHPWPPVPTNSVECSSSFVQALNKYIDSLSEKKRKKSFVVNNRDKTGMISPESMNASIREIKNKNSQGSSRKIVADVLEPTVRVLREYNGIINTLASADPMPTAIIWGVLNIAIDCANRNFELFEKIQEQLTLLTSELRRITRYDQLYGNSQDMRDALCDTYVYVLQFWDRVHYACTRSRSGKIVDALTSINLNKLNDTIAKIRSSADIIDKEARLSEGGKAETERQSATDWRILQQCDRNEAQFDTILTWLNCSVCQSMADSNLRLIERLREGRSCSWLSQHPIYAAWQDSAGVSSVLWTHANPGTGKSTLCSYVIDTIQKQNMDAAVVYHFYRFDQSFEAVRILKYLALQLFRTYCKTPCAPLDIQRLLLMARDGECTLERAQELITLLAETLPRVYFLLDGLDEELSGRRRHVDLGIVLDFLVGVSVKSPERVRLWCSSQSHPDIVKKLAAHQVLDVKDQMASSVTDYLITEVSMLPEYVSQEEQTFALQQLQRRVEGNFLWAKLMMEEILDAQSEADMRRIIDENSSMDEYYKRFFRRFTERDQELACMVFALVAFARRPLKVKELNEAVAMLRSQDHQSLDSRQRVFIEKLQKLFAPLIILKKDSDSQSDSTCRLVHSTVFDFLLRHPDILHDGKNCRMQIRPSVIADACLLYLGQRRYAQLLVEKDDVWCDAELTPVSEQHFLFYSAKYWDKHLDYVTDPSRDLHARVDAFIRSTNFLTCVQTQSLWVDQQFNVFKVLGVDERFRFFRRVFPDWFVETEDGHCLRSNYHRFLHEWKTLLNERTGQIDRCWWAALGSHNFLSNHGGKYKSFCLHDDTPEDEFDGLCFQAISPSGNNTKILRLSAHADSKLEFVCEHWTQSFPGEAPVISNRQKISTTEAATNWPLYASKTTDGWNLREDRASPVVFSEDCRHLRIGAQIFTLGIDGEYLAVRGLDADAKGGYKYVEELAGRDRFIVLATRRDVSVGKDARIKKVRKTAETTSKPQDFAKGKSGSKNPEDSDDDSSDDSIPSEEDYDDESDLDADDTSDADRSEAYESWSECSSENTEGSQFEDDMVTPWAQPVDSNLSDKDTDTSSDSSAPSSQQSRSETTSEDEDELEALNKRHKGVYTQDDDGTGSDSVETHSDSGRLMYEKLMRQRVPGTSDEDEDEDEDDEDEGEGEESEEAMSSYYGSTKGTQISNNSEDGSINSEPFVPRGAIIGLGLQHDDEDFMDRSDDEGPQFQCRNIATNLKTTLAFIKVIDTSGEIPKRVFSFSQKLAFLLYDSPPVVHPSASLVVWPLSSGGILFADFLDNTYFVRKLRPSTPYTCGRFLHIVSLEGQRKPLPRMKGKKKGERDTNLSLLVATYHLCRTKPSRSPPYLIHRAKVHLGAVEKIPAMNLLPYTLTWTPDMLFFTCSNNTLRLYRIKLFNFEKAPLNCETFVQMPRETINLPDSALGRKVYFFPGVTCPTTTSTSWIIVGATAEQALAEVHSRDKASPPIGCFFSDADLGGWEKSSSCTPIPMNRGVGRFDQHLEAFDSDEDCDCESHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVA4</accession>
    <name>A0A2R6NVA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000797">
        <property type="protein sequence ID" value="PSR77366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVA4"/>
    <dbReference type="STRING" id="98765.A0A2R6NVA4"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="40"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="181" mass="20015" checksum="094153DED0D514E0" modified="2018-06-20" version="1">MFDPESKRADRPFTHGLLDRDAGTRAALKSYFKIILLSTVLISLTIWAVLGIYWGANWRVYQGIHNMNGWIVDFDGGLIGSTVTQAYLNATGSQEQVSWAVVSPNNFPNGESGVIDAVLNERCWVAVMQQPMAQAMAVFALEQARRLSPSNTSTLLGSAPELILQPLNYTIENIRPFDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWK7</accession>
    <name>A0A2R6NWK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWK7"/>
    <dbReference type="STRING" id="98765.A0A2R6NWK7"/>
    <dbReference type="OrthoDB" id="6088208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47261" checksum="B57B6FFB6265045D" modified="2018-06-20" version="1">MSTLKHNIRQQQAQLHTLESTILRGPRPLPPGVFNSQDEFDVSTLSHSATPSTSHSPHSTPKLLKRNSYEVLQSLAGPESSLPLPRRDHRASSFGEESGRGINGIREGIPMASPNLRAQSPTRTLSRNARALAEENSDSHLNASTSSHQPSPISPNRRASFAPGNTTKVLADLQAGVLNAKNALENTKGQLRLSQRQVSQLTRQTEDLKEVRERLRLENEGLNNVVARKERLLQEVLERARKAEAEVVVLKSQLKTETTTSKKSLRDMEAALTESTARSQKCEREYITLRDSLKGLVESFKTDHENLREEMRKREGKMRKEAEEISKKYKRLLDEVKKEREGGGQGMNAIVKLKMESEKARHDVEEGLKEEVGRLREEVDRSSKDSEGAIKTSKNLAEELARLRRLMRASGSSPGANPGDPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWT9</accession>
    <name>A0A2R6NWT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NWT9"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="128" mass="14073" checksum="5043B297EACCD6D0" modified="2018-06-20" version="1">MLRPLGYRILHGSQVAIITPWRCISTGPTGTVASTPSWKEPGRGGQNLSQRYERLEKSLRGKGTYQQAISQLSHEAASPLTPSARRTKDKREIFMGLVVPEEPKPPGPDGTIILVSYTLKKVGLILDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWX7</accession>
    <name>A0A2R6NWX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000728">
        <property type="protein sequence ID" value="PSR78711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWX7"/>
    <dbReference type="STRING" id="98765.A0A2R6NWX7"/>
    <dbReference type="OrthoDB" id="2563011at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015310923" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="19"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR78711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="558" mass="59566" checksum="D07996E7437CFDE6" modified="2018-06-20" version="1">MGVSMVRMAWFSCAFIVLTRSQQSTGTSKQDFNFTLSTSTGFIYVAGTNDYANNAVTTYNETASTTSHVLRNDITANILGQLTDVAVVKETCGFVTSDSSLWSYENQTIILPKDQTQSALQQSLSMQLGSEISGIVGLGTNRRSKPSSNSWNTSSPSSTSQSVFQPDLNDSIAGQFFLRSPASKNFTFGMALEPPIASASGQSVTGTNAGVLHLLQPDTQFYDTASVSWVNASVTEPTNNGTLPQSDWSVILDGWVMNGEGSELTSKGQIVGNFDPLFTNIYMPEDQATLIHTEIFGSSFHNNYSTLGNLSKAWTVPCDTELTFGLVIGSQTFEVDRSILVIDHGNGVCVSGIEGWTNIFESQYMFGSRFLSSVYLIFNVASSGAQTVGVAPRRMDPSSPSSNPASSKLDVDAIIGGVIGGTAILVLALLAASYLHRKYKTLLSTERVSDYYRSRGVINDDDDLKSPGYIEPFMLMSPLSAAAAAAATSPATGTASRTPHQGLRPPSPKKSSPPRVSIPFLEIRNGAPAPQASDIADISGEARDRVVDGFDSDGSFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXM2</accession>
    <name>A0A2R6NXM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000696">
        <property type="protein sequence ID" value="PSR79414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXM2"/>
    <dbReference type="OrthoDB" id="3230658at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11458" checksum="A5770AEA79F2EFCD" modified="2018-06-20" version="1">MFTVPNVALTNAMACRVFRQVKLGVLVERPSEISQRSGTIKFSTPLSVRRIGHSATATYLDQDSFLSDLDNKGTLRVAIRRETETASHEASSSEGGKGTDLMENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXT8</accession>
    <name>A0A2R6NXT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000693">
        <property type="protein sequence ID" value="PSR79533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXT8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8180" checksum="68A9171C1482B79F" modified="2018-06-20" version="1">MDVRGSESSASDVEDDSQDLCQSISWSCNYTGLFILGMVSSKVGGGEYTRGQPEAAVGIRLEVEWNTQQRAGAYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXY9</accession>
    <name>A0A2R6NXY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXY9"/>
    <dbReference type="STRING" id="98765.A0A2R6NXY9"/>
    <dbReference type="OrthoDB" id="3238622at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="291" mass="32750" checksum="A2A8B77B7DC4B09F" modified="2018-06-20" version="1">MHMENTETAVVCKEQSDTYHPLFSSPGADVVLGARDGVLFRVHSFTLRTTSGWFRAMFSLPQKSESEQPVVIYMDEDSAVLEALLRCVCGLAIPRMDSYDLLEPLLYAAEKYEMPGPLSIARALSMTPPLLSSPLRLFAMACRYGWEDVAKLASTSSLSLDIHSPEHRTVLQKLTSVPLLNLFEFHRNRRELLRKRLNEAPFVDDGGGASCSHCGSAVDYHTWRELKYVMVLTMDSRPLGDTICDPGLTEWPEAQACWDARCVTCSRVLYDKKETLRAIRDCIDQLPIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY24</accession>
    <name>A0A2R6NY24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY24"/>
    <dbReference type="STRING" id="98765.A0A2R6NY24"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="280" mass="31049" checksum="6A59E3F195CC720F" modified="2018-06-20" version="1">MTDSNIASSSQQTSISPDLSKFLAERYPLVKAQYPGQGRRKWRLLVAEQFWALPPIEKAAYAQARLYASWDCRSVSILLTRSYILTLQTGPIPTADAENEAFATDDDPLDSVTVEASGLGIVLRTDFSNDQAWHAFCDKLQQAEAEFAADSNASIDENTPTTETPQHEAMDEDGSEEGEEDGDEPSPVFYVLDPEPIHRPAFTAISNITALRVLNDVDIRPAPPLPSSMKRIKPSNRLVDHDGWQETYTGKMVWIYDTKSNTDQCVRLVSQQGAMYGTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYD5</accession>
    <name>A0A2R6NYD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000669">
        <property type="protein sequence ID" value="PSR80101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYD5"/>
    <dbReference type="OrthoDB" id="5389493at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="19109" checksum="746BB160D504D999" modified="2018-06-20" version="1">MVNPGDTGGRTGIFLLLGRILKYRNVMRLIITVTITLGIYGGWEYGGWIKPPFILLVIGVMCLISEAYLVSTANNLPTVGSLPPLNVFQLLIQPYLFVQQNHAPLFYSLAALPEFIAVMMFMVPGLVPSKIELLECVNASKSARVADLWILPMTHEPRYYAPIVLKLVECSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYD8</accession>
    <name>A0A2R6NYD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000667">
        <property type="protein sequence ID" value="PSR80132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYD8"/>
    <dbReference type="OrthoDB" id="2795836at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10191" checksum="1DD4F147E8DA0CC3" modified="2018-06-20" version="1">MEGFMENHGHLDGQSSVETHMYTNCDSNAHIFDLYSVGTGTALVAGKGQGDNAAQPFVDHIAFHGPQGELVRVKALIDDGAMVNALDISGDFWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZR9</accession>
    <name>A0A2R6NZR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v6348</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZR9"/>
    <dbReference type="STRING" id="98765.A0A2R6NZR9"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="201"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR81582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="668" mass="73326" checksum="B499AFF2EF87198E" modified="2018-06-20" version="1">MLRAARLAGAPAGRAAVRVSRRRFATELPPAAPKKKKHLVRKFLVYTTAATATFYVGSAFVALDSPEYNEFFVENLPLGASLVQYAEDHDWDTLNLEKAITFAKDGVTYVQNLFGSGETGTVVQKTKEALEHAKDASKERMQSVAKSLKTTVNREEGKLAGRSNKEAALAKHRAIQFSEGVEELATRAEAAIAGKLAVPVPDVTTTPAQPETVPPDSVSSQASGSVTASTTNDSKPKNVYDAPLPIGFEPPPGYSRPAPPKPAPKPTSGTSSEAAPSKLEVVPAPPPLPLLAPAVSEFGATEPVIAQLASVIDNLASYLNTNPAAAEKARDVLDTAKVDLTSLATRIEQVKEEERTKLETKLDEQTREYTVKLLELEMEAQDKLDNQEEGFRKYFDEEKAKFIHAYREKLNHELQTQSDIINERLKEEVVAQGIEMQRRWIREIKIRVEQERGGRLAKLDELASNLKRLERIALDNSTYLDENLRIHALWSSLRALNHAVDAPVRQPFREELRVVRHIAAAREDPVAATALDILESSEVPDVGVEPFADLASWFSTSVAPRVANVALVPDQNAGLLSHLASHFLSSFSFKRQGLVPGDDVLSIIARAEYYLNEKDLDSAARELNQLRGPAKVLVMDWLNAARQRLEVLQALEVVQTQATLASLLVAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0D1</accession>
    <name>A0A2R6P0D1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v6156</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000600">
        <property type="protein sequence ID" value="PSR82086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0D1"/>
    <dbReference type="STRING" id="98765.A0A2R6P0D1"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015307080" description="GH18 domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="57"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR82086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="314" mass="33781" checksum="68E8889A4A9364BB" modified="2018-06-20" version="1">MFSLRHGLVLAIAIFTTILAANATQVMHKPANFMDAPHKFETGNATPRVIHKRGGAKAQIAYFTNWGIYGANFQPTDIVPGPLTHVLYAFADVSPDTGVISLTDSYADEQKHFPGDSWDETGNNLYGCLKQLYLLKMAHRNFKVSLSVGGWTYSQSGHFDFVTDATKRATFVSSALQLIEDYGFDGLDLDFEYPSSTAQGQGFADLLTSLRSSFDTYAAGKGDTTPYLLTAFRYMDVPSKIPMASAPLIMAYPNSKWDNIRSNMGTIGSPTSSSSTSAPTGGGTGQCAGIGAWSSASIYTDGMTAVYGEKLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0E1</accession>
    <name>A0A2R6P0E1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000599">
        <property type="protein sequence ID" value="PSR82130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0E1"/>
    <dbReference type="OrthoDB" id="2745635at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="339" mass="37865" checksum="FE7914CD7D91273D" modified="2018-06-20" version="1">MPAHTRSQFARTLLATPPSTAIRISSPSALERFVLRANAESHVGLAVEELEIGFANSVSFAGETLRRCLQLVPNVADVILDLPPRTPSNILQHVTFPHLQLFKTNLPHYTLLDFLEAHVSLKLLILGSCGSPGECAFASLSHVDHIVDLEGPSQCISHFMGTRLVRLTAHLSYDWYSKFATRSLPLSIHLVVLSMEFLPDDFQVLNSISQTAPSLRKLKLMENGIPMRRGSSSRRVWNDFKGWAMSLRKLRLLEELIVVTPAKLVRHSGDVLEEKELLGRWLTGRRNHPGSPSDSYLYHVGLWYGSQDLGESIISNWYKVGVTWARSVHNGQPHPASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0I4</accession>
    <name>A0A2R6P0I4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v5991</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0I4"/>
    <dbReference type="STRING" id="98765.A0A2R6P0I4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="127"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR82558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="193" mass="20798" checksum="484F16F828FDCE98" modified="2018-06-20" version="1">MSCDPNYIFSIDNHNMTIIEADGENTQPLLVDSLTIYAAQRYSFVLNANQPINNYWIRAQPNQAQLSGFANGLNSAILRYKGALDVDPTTIQPVSVAPLLETNLHPLSNPAANSTDRSFTVNGTSFIPPDLPVLLQILSGAHDAQDLLPKGSVYGLPPKSVIEIVIPPGTAPGGPHPFHLHGVSNCLNLPERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P187</accession>
    <name>A0A2R6P187_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P187"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015333207" evidence="1">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="13723" checksum="B00DFD2ED345A2D6" modified="2018-06-20" version="1">MFPFANLAQVIALASLGFSFSSAHPTPGGSELSKRFDDVPIYKSQGLGTACGGPIGPEIINASMPLFQSRRLVAENPIYGHLKQLFALSPQCQDPGCVGGAISLNPFLFEQLVGSTDVDVVYGSWDFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5H4</accession>
    <name>A0A2R6P5H4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5H4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5946" checksum="487F0E385FE4A1A2" modified="2018-06-20" version="1">MSKFNDEKSIIEIPKVVDALDENQTHQDVFSDEESHDIHYKTLSWQASSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5K0</accession>
    <name>A0A2R6P5K0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5K0"/>
    <dbReference type="STRING" id="98765.A0A2R6P5K0"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="7">
        <location>
            <begin position="201"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR85872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="491" mass="55697" checksum="0820E473B6387905" modified="2018-06-20" version="1">MPIFQDQNGMAIKFFIQKDIPDDIQAEVCETITSLGGRVEAKVPRAGYILVQPGTSEEERLRTCWSTAERPERYFVPYTYVEACKMNGMLLKQIFVHDGHPIPMHIDSSIANVNVRHALSTRIQHSGGDPTASPQSARVILADPNTEIFQHLVKTHQSETNKYVESYLWVKKCIERGAVVYTPVVYKNPGGRRAGEERTHFTEEDEERLCDWIASKIPYKETGGRTGNRLYRQLCEMANNPDYGWVTRHTWQSWRERYKKNAPRLDIRISGIVERKRPALGEKGQYGYVRKPEERMKRSKKKVSQDGEGATVAGPSNDELDFMSEPVMLAGPPPPGVPGALPPTQLSDLVYPQLDLRFPHENISPEVAAARQNATEEEDDESEWQIRVNDGTQPQWAKRKAEPEEEGPIKKQHTESQASPHSEQSGLHVVDQAVQDIADEYRFTVGEVKEYYDKCGDVDKTRNRFRKMREILSNLPEDDPPALAPNSSAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8H8</accession>
    <name>A0A2R6P8H8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000520">
        <property type="protein sequence ID" value="PSR87007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8H8"/>
    <dbReference type="STRING" id="98765.A0A2R6P8H8"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR87007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="80090" checksum="2FC3286CB219F834" modified="2018-06-20" version="1">MEKTLLEAAPMVMQAVTACISRPRPHPSQNELRSALKCFEAWLFILPSNNLTAIVPLLINLLTPISGPADFDEEEFELAAEALEEIMSRSALAGGTGTKTLTEPLLLWFERHGGTIVENTLKEGFADSVSRSLCKLLTALGDHSPEYLAANLASSVSPSPVLQEPISTPLPPKSHLIQTFLRLLLAFTALPGYYGVDEEESEMTLGFWYLFQEALWSTDPEYNEDDEAPPRAQGEQGNISRAVYSELVQALRRKVVWPEKNILQPWARGEYASWFTTQPSHASGSLSSLMTTISYIVSALSDSDLCLHAANSLRSVCDANRTALAPHISAFGELHAGLVGINDTEKSKVLQSIASVIQALPPEEEIPPVEAIVSPVVSKLYELLQSPAQLPEETRALVVQQLQTIAGVARGLTRTNDSLLIFDDSPDMKQETERMRRARQDPRVVRLRDAILDATRRTVDLWCTDASVSDALSELCKAITSLPSDDTLLSLPAGPLLELICLASQRQLTAVWLNLATMLIIQMDPPALFPTTFKSVPSPEARGTVLNAVTALLQSSLNMFGQPGAMVDNPDIVQAFFISMETVAQHFTTIFYDISPELFSALLQCAIGSLSLQERYSLVSACTFLASLVNRTATNDQLGDAKAVLVQTHGRNIMYGLLNGLAGVAPRSAMVNLTELLSTLVNRFPLESKAWMSEILYSPDFVSSKATNETKEKFLKTIFKSGASLFYLIVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8M0</accession>
    <name>A0A2R6P8M0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000517">
        <property type="protein sequence ID" value="PSR87139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8M0"/>
    <dbReference type="OrthoDB" id="2724825at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46682" checksum="FDDD22308DAF2AC3" modified="2018-06-20" version="1">MQLPIPPELSDQIIDHLDQDKLTLASCSLVSRSWHNRSRYRLFHSILIRESSRLEAFLAYLPSASIRTYVRNVTLGDPRKEVDFRKMSIGPTSLALLSELLPQLSNLFLLHMTWDSDEHINPPSQNCKSASSPCEYLDHLTLCGVMNAKGKPLATYEIVSVLRLFATIDRIQVASCQIAFDEPTEDTMVAEDAATLPEISTLWLAYSPANTRLLHLFRNSGLAKSLEAVDVHASQWSTVLALGALIREIGPNLTYLAVCYKIVAPNSGETVDEFRHALSVSSCSSLSRFHVSVLLRPGSPVVSLWQWDAMIALLQDVPAELITHIELSFIVENYPNPDDAVTQLTQFNWKRLERLLPRFRKLEGIVITRSEVETPSLVGNKIWTVAAQRLSSLTKKKIPLSGRHYIWKAEKSVSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGR1</accession>
    <name>A0A2R6PGR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGR1"/>
    <dbReference type="STRING" id="98765.A0A2R6PGR1"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="6">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR90595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="311" mass="35110" checksum="F0601A218C0C91AA" modified="2018-06-20" version="1">MSLTTPNNRRGAHNKGGIRRNENNKIYGHPLPLIFSEPSNVKYYSPHRALGLFGISSARLETPHCEGILDTATHSVWIMNSGDAMILWRRGFFGKGDLSRSEPSWYTRQANARQAAGKYLTSEEIREKRRAERKQFKLDRARAIAEAAAEAEAAFAEGREAPAIAIPSGATWKPQSSMSDGHETGLPPQIDNGDEDFAEEEPLEDVEHLQLTLQEAFFLLWNLNCLTVLDPATNDPIDLKGIWFAFQKAYYPPALPASIYQSYACRFDNPFLVNYVAYHHYRSLGWVVKGGIKFCVDYLLYKRGPVFQHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ90</accession>
    <name>A0A2R6PJ90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ90"/>
    <dbReference type="STRING" id="98765.A0A2R6PJ90"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="220"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR92208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="306" mass="33392" checksum="2156BC202C545EE6" modified="2018-06-20" version="1">MPGASNSDDEDDEEEEEEEDSEPITTVLCSLTPGKIEQATIDLILEEDQEIQFEAVGKNTVYLTGNFVDQTPAHAHGDEDDFSDLSDEDSYDLEDVSSDVEINPEDLEDDSARFEEINTEEPPKDSKKRPRDSDVTDADEPKLSKAEKKKLSKKLKAVNGEAIPTGQENVEPKAVEKKEKSKKEKESAEKPKPKAETKEVTGGVKLTDHKVGSGPQAKKGDTVSMRYVGKLQNGKVFDSNLKGQPFKFRLGAGEVIKGWDVGVAGMQAGGERLLTIPAPMAYGKKGQAGIPANSTLIFEVKLVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN39</accession>
    <name>A0A2R6PN39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000467">
        <property type="protein sequence ID" value="PSR93882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN39"/>
    <dbReference type="STRING" id="98765.A0A2R6PN39"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase meander beta sheet" evidence="4">
        <location>
            <begin position="166"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR93882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="248" mass="28249" checksum="2760E15764754652" modified="2018-06-20" version="1" fragment="single">MDNQRPYAAPQVCTKVASFLEQGQRLENLSWRLWHLQNLMVETDDAKSKHEFRKLLKCMSDKSDEEKGRSIEELQAPGSRRNHSTDIIQQCAIEKEREHEAQSGRPGIHRMQFTFSVDQPLAPTGHSPPAQKPDLKLSPEFKDNCAQQGIDSLHRCGGSCSGAARSYGDHKANFKAVETKYNAASRLIDVTVFEPRHDVSVPLQFQFEYKPSMGFAAIHEIAADHNKPIKVFYWKLWFGDNEILPEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNM8</accession>
    <name>A0A2R6PNM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000447">
        <property type="protein sequence ID" value="PSR94555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNM8"/>
    <dbReference type="STRING" id="98765.A0A2R6PNM8"/>
    <dbReference type="OrthoDB" id="2796228at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR94555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="25479" checksum="F54EBB0F366780A4" modified="2018-06-20" version="1">METDSPADVRTFSKPGLVLIDNQIGFTHPTHWGVHRSNPSYEENLGHLLSAFRDRGHPIFHVAHHSTDPNSPLNPISNPLGAHFLSFAEPHEGEPVFIKTVNSSFIGTTLEKAIREADIKELFVAGLTTDHCVSTTTRMGANLGVVGETGEIYVVGDAVANFERGKWDAETVHQVNLASLDGEFAAIISTEGVIRSLQNWYVPYISTSFIEFSSYHDITDDITDATNISTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVG5</accession>
    <name>A0A2R6PVG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVG5"/>
    <dbReference type="STRING" id="98765.A0A2R6PVG5"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR97588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="280" mass="31033" checksum="5A10163883FEB61E" modified="2018-06-20" version="1">MSATNITIRESTSTPRTKPHPQKSSIPVPFDYCPSDDGTDENLLILLHGLGDTHVPFGRLGRSFKLPQTATLALRAPDPLPYLEEEAYEWYTSFNLLGELVRNPNPTPAVDLLMRVFAHLTTDSSWPPNRIHMFGFAQGGTVAAEVGIKWWRTELERLSKDKKDKAGETSEDTKANEPSLLGSIVSVCGPLISYPTLQNLCPTPILILHRPAPAETALPSGALSAFKKGYSNITDLQMGRGEGMPRSRTEWEPIMRFWSERLGKRQMDGLYEVMSGITPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYY7</accession>
    <name>A0A2R6PYY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYY7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR99054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="150" mass="16706" checksum="CCBE9DF7F06890AA" modified="2018-06-20" version="1">MGGNLDLIQDCDERGDNRERNNRANAQLVNALLSEKLLYCVSTSPGLTGLPGLPLTRFDFECDCRRRWGEASRHGERERERAGDDEREAKAKLRERKDERGDDGEDLGERYMAEKDEERSGEGIGIDKPGVRGVLAKAPAAGDDVANMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QED4</accession>
    <name>A0A2R6QED4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000364">
        <property type="protein sequence ID" value="PSS06504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QED4"/>
    <dbReference type="STRING" id="98765.A0A2R6QED4"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="112"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS06504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="556" mass="62479" checksum="D2A650CE53B83AAE" modified="2018-06-20" version="1">MAPESSPQPWMPKARAGLKKSPPYWYAYTTMAKGRWLGRELLEIVSTEFRDRSMEYYRYAIESGVTTINGKVAKPDTIIRNGDRMENVVHRHEPPVTATPVKIILRDEERGFVVIDKPGSIPVHAAGRYHKHSLVEILKSEFGFKKVYTVNRLDRLTSGLMILPLSASGANEMANEFIAGTIRKEYIARCKGKFPEGEVICEEPLLTIDRQMGLNVVHPDGKHAKTIFTLIRYDANTDTSVVHCQPLTGRSHQIRVHLQFLGYPIANDSIYSETKIWGPTLGKGGIDTTPSEERAAPVAPPQFQFRPEDNPESLSKSKHAFSGAQDTRDADVESGEQKLLPRETGHDIGMGSPVPLSAEAVDVITKLRTMKIPLLKLIDQQDEDEDWSRWRDVVFRAKGALHPNHIVICSPPPQNERRRGGPATLRKNAQEDGETPPPETISETELPDDTPIVESINDAELQESGPAEPPQITLEEALEKAKAHESSEEKTSVKILAHPGTEELIFCPDCYLPLHPDPKPERLYIFLHALRYTTSLGRFETDMPEWAEEGWEWDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QED9</accession>
    <name>A0A2R6QED9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000364">
        <property type="protein sequence ID" value="PSS06497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QED9"/>
    <dbReference type="STRING" id="98765.A0A2R6QED9"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="18705" checksum="9C6CBD83B6634C78" modified="2018-06-20" version="1">MGHQTQIFFPRSIESEYAVKQASLQKSSFHLRTVRSHTRTAEHRNSYAAASPTKSPVSYTSEYNGGLNTLGKHYPDSMDSPTTMKTALDIEAYSPPQPVAMFAPNRRLPSGATVQGGVAVIAGGLTDQNLAQHDFNTTSVHPFVHNFTSPIAVVFTPRPLFITLYRLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEM1</accession>
    <name>A0A2R6QEM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEM1"/>
    <dbReference type="STRING" id="98765.A0A2R6QEM1"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11952" checksum="7738B1AB024A402E" modified="2018-06-20" version="1">METIPANKWVREDPDKIGHESIINSTMMHPHLPFIATAGIERHVLLHSPTATTPCTDELTHTPTAVRELPEANFNDRRRMLRALIAEQADNELDQDRDTIALFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QER1</accession>
    <name>A0A2R6QER1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QER1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="10969" checksum="95BB96BCEEB936BF" modified="2018-06-20" version="1">MVVSDPAELRPMQPSDHTVLASAAEARKCCSFMNFMRDIGILCYTILAAEEVATLPSRPTGPTSGVTTQSTSMSQISSDSGAVIAAFQAEYVISRHFIAGRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF11</accession>
    <name>A0A2R6QF11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000343">
        <property type="protein sequence ID" value="PSS07208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QF11"/>
    <dbReference type="STRING" id="98765.A0A2R6QF11"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS07208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10055" checksum="079D94A34A0373E7" modified="2018-06-20" version="1">MRAVQGEGQASGYIVEDVVSMGSLTVEKQQFIAVQTTSDSFLDEPSDGLLGMAFGSIARIHAPTFFENLLSGYKLASGIFSIYVTRGKEDGSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R780</accession>
    <name>A0A2R6R780_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000275">
        <property type="protein sequence ID" value="PSS22609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R780"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS22609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10133" checksum="01B52663FA8E52E9" modified="2018-06-20" version="1">MDPGDRNDPHRRRAPALVPRVMIGAAFGAVLVAFLLRPIHLSVHLHNHVNINEGGILNENVIKLDTEAVFVAAATIGRAIGKVIEFVKGLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7F8</accession>
    <name>A0A2R6R7F8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7F8"/>
    <dbReference type="STRING" id="98765.A0A2R6R7F8"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS22672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="240" mass="26295" checksum="2BC8763BA9F08A07" modified="2018-06-20" version="1">MFRTVLSSRACLPLYKIFPRIIGPVLTVTLFATGAAYAWSKGTDITLTNSVVPLFSVVVRNLSRLIWINVAVPPADDSSKGKSSAATLTAKELRRQKVQAMKLCVCFTFAVKHYLRGEDGLDWDDYIGILPPSVTRLARPSTSRRSSGWTSYAATAKTSGTDSGTASRDEQDVEGTTSESGPEIRRENADATKRIRVKRSKDRLKQGGVRNSRTPLLSALHQTIDFNPNPENLSTPLPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIB1</accession>
    <name>A0A2R6RIB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v2910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIB1"/>
    <dbReference type="STRING" id="98765.A0A2R6RIB1"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="9">
        <location>
            <begin position="402"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="609"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="657"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS29762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="764" mass="85464" checksum="9EFB949935D10B44" modified="2018-06-20" version="1">MQSLRTRKPSQSQPKGQKPGNRLAKSGTRDARKSTRVDDKIKKRMSMRYADISSPTDASVPAVPSIPFTLRPGTYKDSDEVPRGREQPKEDTKEIELKMLDKDDFDPDAFLKLKMANSTEAELRSLQSSLRSSKDEVALDLQRNVFKNYAEFVMVSKEISTLENEMLEFKEALAEWKGMPSLLHIDDSASVTERRRNVRSSIADLRVLYANQMQNLHTQIEGSSKFIPTTPGRHVILEMDSILALNPATYKVDHSVRFVLLDDAVLVARRRRRRNNSETDKLIAERCWPLNDMLVLDTKDTASMTNVFKIRHNKETHVYRTEIGADKKQLLTQFRQVAEELAAKKRKEREGEHQRRKSLWVGGDRTSHAFVPEVPFPDFLAEIAAKSEMGSTVSDKAERDLRWIGDFSDDLTVAVALRQWDRAVSLIEDGEGKLNSMPTLAAKLTPLKSTLTAALLQSLSMPSNRKSTVVHLISLLVRLKAGAAARNTFLTARTDVMRKRVRMITFEGHIGMYISDLAIVMFTGIKHTADWFLASFKENEVASCFIEWAKSQIQSYAEMFRKQVYTSDTDPATVEEAIKLTRLQSKRLLEEYGLDFRFLLDQLLVENPQEKAKPTPPPYKPHTQKAPEPIYTPASTPIRSRSPAPTIAAPVPSRMRSPVPAVPSLPSTVSSSPVTQLSSSPADSPASTPGPVPTPRIRSPVPRVPSSSSSFSARPTTPSSDISSRMARPLRGSPAPPPRSRDRPGSAAGHRPPPVAIPRREGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIC3</accession>
    <name>A0A2R6RIC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIC3"/>
    <dbReference type="STRING" id="98765.A0A2R6RIC3"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS29777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="18788" checksum="DC0C15EE958AF554" modified="2018-06-20" version="1">MANFDPHVRRGHPIVFGLLILFAIIELALSAWLTSRYNAHHNFPSTGVRDRTRFLLFTSIWTVFFSFLYMILFLHSASSGSVLTSVGSHGIFLFITWVFWIAGSAAITAALGGGLNCGRDPINYCDQLNALEAFGWIETVLTTFAILIVMFRGISASRRGDGLRGQLVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIH1</accession>
    <name>A0A2R6RIH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000255">
        <property type="protein sequence ID" value="PSS29798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIH1"/>
    <dbReference type="STRING" id="98765.A0A2R6RIH1"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1097" mass="125834" checksum="CE53730C76787C7B" modified="2018-06-20" version="1">MPVPCPAIAFESDTDDFMYNVAYVAELVQAGPPVGSHMERILDKQGDKVDDLADQVDAVNDAHETVQAFKSGVDTFMEDAQCFVKILDEVAKLHPFVAAPILAFKAVYSMERTRRENDKRIISLYVAMKDMIVVLIQLQNVKDPTHVGPDGVTIEARMQSLAGLAAEDIKDCANVCDTYSKKKLLVKVLKGPIWESRLAEFIGRFARRQSDFKFALAIHTATVADSMREAVDGIDDKVAVLTDMLHMVFKEFKPQDEASLAAKVDEKGGADYVQGNDMILRELLAYEDSIVLANQNATSRIEATRAEQFSSTEIYAKLRPDMNEQSTRQSSLKDLKNDLGEDWKTAVDRNMQVFQRKFSFRKKQLQELSLVIHEENDRIIQELSAGPHDTIHNKGWRRNVESNLFVTTLRDHFKDKLEMYGPRPKGAGHLLQDEWAIKYLGIRYLRLLKEALDEDGSGYITTSEVNRFTERLPENLGWSLQHWIAYWTIGWQISAASYREQIRRLFAQMFAMRSKILPENRRLVDNYLQKVWSSGVKLVEALQPVNTVPSHIKAKFLPYVQYEEERIAQNLDGIKYNIDALDTVYMVTGPGRLENHIFPLMYLLLRRDIELFRLAKHQIFWQDDLFVTAISNMQWVYDAVTSRYRELSALFKHKGLDVGSQMKIFACELFEFYHDASPLWKSIHAQTKLDQEAIEGFLDPDRERSRFDLEMQDSTTDFQSPYEVSRHFHTNTQVNVEAVASIVLGEWNGFVYSPVQYPMFLMTSFCAHISPYNDAEFEANGDHYGATYQLAGRCFKDKDGKTRVTFNIHYSQEFRTKYYSGYLTEDGSLIGSQGWKKDSLTHQYRFILKRTPAEVMCHRPSPLEFQANQPRALWKFAIRTVRHDLRKRLWSWSFFANRRETRLRQIHFDIRNYTPFGRPLSPEESAEWALRRHNMTATDANFYRNIRDIQLKIVPGHPGVVCAACSYRIGGARIVCLDCQPNDGDYSHTVDFCDDPICLGTTVTTDTRNYLLSSHTPSHDFFKVRSVLHLRDLPAMDSDAKKALAASRNSFDDPHNTDDNERVYYNSGSAIDGRTMILKPTRTGTLSLKTSSAAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLG3</accession>
    <name>A0A2R6RLG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000243">
        <property type="protein sequence ID" value="PSS30871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLG3"/>
    <dbReference type="OrthoDB" id="2953893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="54"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS30871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="237" mass="26194" checksum="F2F7D0ED26273F5B" modified="2018-06-20" version="1">MPKAIVACVYSLEVLQTCMSTVDSFRDFGTGWGNMAELDNVGLLWFSVWLGSAALNDIIISTCMIYYLHRSNTGFRHTSALLAKFIRLTIETGAICATFAILDLAFYVAFQNNNYHLAPSIPLSKLYSNSLLVVLNARVRIVGGRDNNDADSASLSYFNAVFPESNGRHQSRTQPLRKAHIRSGGISVAITHETQSDHLHVPMGECEEQSDIQKFDGSPLDIPPEELDIINKNAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLK7</accession>
    <name>A0A2R6RLK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLK7"/>
    <dbReference type="STRING" id="98765.A0A2R6RLK7"/>
    <dbReference type="OrthoDB" id="2800760at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS30911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="164" mass="18982" checksum="82ADF9323EB5C93C" modified="2018-06-20" version="1">MDDDGQPIKDDEGNPITKIDACVSDFEMAKVFDEVNEHSSNNTLTRQASARWLAPELVNTIRAEPPSDVFSFAMLMIELFTLQPPFPHLRRDAQVIHRIVVMKERPPRPRSPWVSDAMWQLIQECWNEQGDRRPTMGQVVERLKELENQPPVTLEPEEEEMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM44</accession>
    <name>A0A2R6RM44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM44"/>
    <dbReference type="OrthoDB" id="2527451at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="157" mass="16660" checksum="64495A9CBDD5A106" modified="2018-06-20" version="1">MAGRGCFNCGGFGHQAANCPKAGTPTWWPGRPFIEGLHWGSEGEDLLQMWPRRPFVPSPVLEPLPPRSAIAAESRDTSRARAPKPKTAEASTHSAVEIKSPVTLAGASDISPATAFKAQNVTIVTASGIYQKTARSPNVGLAIRAVRKDTFLVTALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RMC0</accession>
    <name>A0A2R6RMC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000218">
        <property type="protein sequence ID" value="PSS31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RMC0"/>
    <dbReference type="STRING" id="98765.A0A2R6RMC0"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015318729" evidence="1">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="16068" checksum="77040E9FEA2442EC" modified="2018-06-20" version="1">MNVLFRHPLGVTLLSALTCVSVLASPTKRQTLSALTQAQVSSFKPYTYYASAAHCPASETLTWSCGVNCQANPTFEPVASGGDGDSEQFWYVGYDPTLRTVIVGHQGTNTSELLPLLTDGDIVLGNLDSTLFPGISSSIGVHEGFREAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPR0</accession>
    <name>A0A2R6RPR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPR0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="15034" checksum="9AB998C4D8EE3ECF" modified="2018-06-20" version="1">MTMYMQDEHEVIYTKESIQLALLETSTNNDPSINSCPTKRTNPTITEYQETQHLRGGELQATFIGLYGGSLAMRRRFHSSALPELCLTLVTTHHMEQHLLRILYVESGVRSLASASASKLLVIQSGANVLAKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPR3</accession>
    <name>A0A2R6RPR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v2212</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000205">
        <property type="protein sequence ID" value="PSS32020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPR3"/>
    <dbReference type="STRING" id="98765.A0A2R6RPR3"/>
    <dbReference type="OrthoDB" id="2993330at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS32020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="17426" checksum="396FAB1DB0C1A80F" modified="2018-06-20" version="1">MGYWTVMSMYGKRKNEKIQLSCRNLEEYIIIHDPELKAKYHGKEKVPKQVFHDAHFEGTIDFNGSWLGKDGLTDLSVPSSPLPSYTTMEKTDSRKSEEIVEGLQILNRRNTRAATEALWHDRYNSKVELRIGWVMLVLPDHTTDVEAESIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVX9</accession>
    <name>A0A2R6RVX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000143">
        <property type="protein sequence ID" value="PSS34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVX9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015313851" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7000" checksum="6A80E8D73BAFC202" modified="2018-06-20" version="1">MFSFKSLAVFSTLAFGALSALAVPVLDHNNVDANAVVVARCDCDSVPNIIADVTVAIAPYIYTLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZ79</accession>
    <name>A0A2R6RZ79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase alpha catalytic subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000137">
        <property type="protein sequence ID" value="PSS35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZ79"/>
    <dbReference type="STRING" id="98765.A0A2R6RZ79"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="482" mass="54045" checksum="064701B5B2D73F9B" modified="2018-06-20" version="1">MEGRNLRERKSKIEKLAEYKRTREGGRRTYKLEEDAAIYDEVTEEQYKSIVRGRLAKDDFVVDDGVGGYMDNGMDDFDEREQAGMSDEEDVKPKPIKKDTKAKAKAKPRPLPPAVTPSISAYRPTVSAAQETDFMASLLGDMDTIDMKPKFSKKRKPEPEPDHEDPFSTSDAPSRPTKYGYRSSYAEGDMSSDGFLDTGMPSGPSSDDDFAVLSPKKKLKTEDAGMTPAIHRLGINRMDGNSSAGESMADTSFDDMDMDAFMDVDEDFTDEKPMLTAKKEPDVKARPLKPMNGALNAEDKKKSLDSIPTWLSVYDSLTVSSEDKLGPTAGSSKTSANPSSISILEDDGSLRFFWLDYLEHEGRLYFVGKAQDKTSKAWLSCCVTVENLQRNLFVLPRERRVEEDEETGELVDTDVVPSLTDVYADFDRVRKKVGIKSFKGKFVNRRYAFGEKDIPRGESQWLKVVYGFDGGRTNLNLPQRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZC1</accession>
    <name>A0A2R6RZC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho1 guanine nucleotide exchange factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000137">
        <property type="protein sequence ID" value="PSS35356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RZC1"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="641"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="866"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1092"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1280"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1160"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1587"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1656"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1587"/>
            <end position="1597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS35356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1680" mass="187708" checksum="67DF07B64197E7A3" modified="2018-06-20" version="1">MSTAAVHSQASPPGDEELAALYNQVLIGFAEESPTSEHSSQKLPSPGDRDFEPAYGQQHAGNGGDTQRSLHSMQSRAPNPAVSTQISLPSSPRSLPTPVVSPTAARPVRRLPPIPGQSAPPPPPISATMSQPFISMPEPGPYHPDHPPERMKLTTNDSSRRLPPTPTLAATNGQSRYSAHKGLPPSPRPSSRLSPGGRPGTASSIGTNAPSISMPVPELNGINGSDGDWSSPINRHSAASVSRNTSDRAAGTVRTSQYDDEPPPRSPSSLDDMYASPNEFSPRFSDTLQPGYRPTSGHSSSQVSTSIPASLYPGPVYSELGRSSSNTSGISSAYPTVARNTSTATTSTTATTTSASSRRTDGDTLNISRTDSNGWAPTPPAKYQPTSSQAYMQPQSSLNESGPSHSAAAGSSGRSWKDNDIIRTLQDIKRPLQVHENYEESEYYDDEDASEEGDDRFFNPALLSHIGVRLRDKVPRGTHVKGSIPYQRAFTGKDIVSTIQTQIQRELLITHGISTNDRRAALQVARSLQSQLFFYEVEWGGRILQDGVEDVYMFLDDQEGASDARIEQEELPTGIVTLLTKCYSVTCDEENPCYSYACPRKREALPPVSSAPDAEEDEEKDDWASTVPSDVLLSLPQSEINRQSIIYKVIGREKQYLRDLDTVESLFIRPLRNAHPPIIRASEVEEFIDEVFGNILDLRECNRRLLEVMYVRQREQAPVIHGIGDIFLDAATEFRIAYPNYVGHLPVAEKRLKDETEHNAEFRRFLEQCARHPDAHRLDLKHFLSRPSEHLQKYPPTLEAICKETTDGNPDIDFLKEAIDAIKKLQTVAQLWTFQSAMNKGPSGKLEWYNLVSEEIRKGMPKKEAKRQSIIFELIKGEMDYVKDLENIEVMYVQPLREMDPPIVPRDRLAQFITDVFHNFGELHAHHRKMLNTFQDIQREEHPCIRSITAAVYDAVLNFREAYMEYIPNYPIAAYRIDDEMINNPAFSTFVEQCTRLPDSRKLDMKAFINRPIPRLLRYELLLKSILDETPEGHEDRETIPQVLEVIKALGKDSEPGVVSAKQKVEVWRYNSNLVFKAGEAIDMDLLNENRSLIHTGKLLRQPDSGFEWSGWTELFVLLFDNYLVMTKPKERDGITKYQVYRRPIPLDLLTLANFTDPPVQRNTGILRPRLRGGEKHDQPSPNPAGSSASPETATDARAVYPCTIHHNGRLGGLWTIFADSSQARNEWKQKLEEAIGLRKVVQESNKVFEVETLSADTFLVPSILPGSGAQTWNHENAYTGKVTCSVPFTTADGRGLVAIGCAEGVWIGFRHDSRSMRRVLHLKMVTQCAMLEDFGIFLVLADKSLFAYHIEALVPSSPQSAHTSQTPQKLSGNKDVHFFSVGNLNGRTLVIYMKKKGLDSVFRVLEPVVGKINERAKAPQTFGSRLGLRSQRSEWFRVYRDFFLPSESFDLIFLKAKIVILCTKGFEIMDLTDFKSVTIPQRDDPRLEKLAKRCESCRPMGMFRSSKDEFLLCYDEFGLYVDRHGDPSRSIQTIEWEGTAEHVAWHPPYVLLFDSRFIEIRHVETGRLAQIIPGNDMRCIWDGRGTTTNTPATPGPEGWNEGMSQEPRVHGVMNSPEAAQQPGGPRVARPVAQHVFELIPTIPLYLPGSLSSPSQSTYFAQSNSPPHSPRLNPALSWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S394</accession>
    <name>A0A2R6S394_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S394"/>
    <dbReference type="STRING" id="98765.A0A2R6S394"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="25498" checksum="B7FDD9EEEBCCAAA5" modified="2018-06-20" version="1">MSECHKSPILFIGGTGVLATEAKGMFPSTTIYDDQDVEQIEGLPDNAPHRHVDLTIVQADQQGYVRAHIVLPGTIWGIASNPLVAAGIQNPYSQQIPGLIRASLDRKQAGMVGKGLAIWPDVNIEDVANLYMKLFDTIMTKQDTVGHGREGFYFGENGEHTWYSISKEIASVLFQEGISQSDEPTSFSKEELIQYWGSEIPRMQAIVMVATRVAVQTDLFLSDGSQLKVQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S467</accession>
    <name>A0A2R6S467_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S467"/>
    <dbReference type="STRING" id="98765.A0A2R6S467"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="18757" checksum="BB9CBAC056227316" modified="2018-06-20" version="1">MASTKSTKGKTSAPKASPKDAKAKAAKKAALAGTNAHASRKTRTSVSFHRPKTLRLPRAPKYPRKSVPHVPRMDQFRTIVSPLSTESAMKKIEEHNTLVFIVDIKANKRQIKDAIKKLYDVQAAKVNTLIRPDGKKKAYVRLTADYDALDVANKLVRYNPVGVTVLPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4D2</accession>
    <name>A0A2R6S4D2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4D2"/>
    <dbReference type="STRING" id="98765.A0A2R6S4D2"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="357" mass="39676" checksum="73DD40931B4B7CFC" modified="2018-06-20" version="1">MPPSTDTADDDTVVVSDSVRTSLESEKWYSLDSAEEEFFMTQTGIQDPAELKKHILAVQAKACEVCHERHVNTSAKPIISYPGPLMRCVLVGRVCSLKIARLPAYGKLLKVGKERKGALFLDIGCCLGNDVRKVVVDGFPMNQVFASDLRPGTCHQQFITVIPKDGQLALIAFAEFWQLGHKLFRSTPNTFPVPFISGDVFDPAFLPPAEIPTTARTVSLPPLSDLTSLARLAGHLSVIHASSFFQLFDGQLQLQLAKRLAALLSPEPGSFIFGSHAGRPEKSVRMEAVPQDFRGTRMWCYCPESWTELWECVFGGKGIVKVEAELKEIMKENLMFDAMEDEATETFYQLTWSVTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4D6</accession>
    <name>A0A2R6S4D6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4D6"/>
    <dbReference type="STRING" id="98765.A0A2R6S4D6"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="418"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="706"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1246" mass="137109" checksum="84A008DC3EC8B3FC" modified="2018-06-20" version="1">MNRRERHNAKARQSTAGQRKKRKHSTGAASLDPEHDPNAVIIVPKSEAQKELDRRERLRQELAARADSKMNSKKKKRLEKYIDKKLKQEERIVLFEKLLKSQAELPNTLNLHSSATLGTGKTMTHLERLEREEHHEVKRIMDGSIRTGKRKRDAYAVYESDDEEDTFGGEDGASGNAPRAEPTLRHDSGTIRPKEVVVIDSVSFTTPPQRPTATVGGALQRNADGSVVAPRIVARKKKTLVFSSWKDKSAKSNEVDIQSDTSFDSSDSADDGDDDDESASSSEGDEDMGSGGDDVSEPEEEPTGRKRFGFKEWAVKQLSAAKGYVASLEAEPLESEEPQSIPLPAKKRKLDTTKPTEMRGPLGKELVLPNTSFAKHLQDSTPADKDIRRNRVVDITRPPEVEAARLLLPIVAEEQPIMEAILLNSVIVICGETGSGKTTQVPQFLYEAGFGLPGSDNPGIIGVTQPRRVAAMSMASRVAQELSLTSSKISYQIRYDATVSSDTSIKFMTDGVLLRELATDFLLTKYSVIIIDEAHERSMNTDILIGVLSRVVKLREELWSQKKDNAKPLRLIIMSATLRVSDFAENVALFPSPPPVINVPARQHPVTVHFNRRTTSDYVSEAIRKASKIHARLPPGGILIFLTGQNEISGTCKKLEAKYGLKALEERKRRRNAAAARTQSAEEDSRGRVNVAPAQADVEAEDMDLGGDQMDLALDVDGDNADFDDEALDSDDDLNDQELGIDTEESDAPMHIVPLYALLPSEKQMLVFKPPPPGARLVVVSTNVAETSLTIPGVRYVIDCGRAKERHYDVVNGIQTFKVSWISKASAAQRAGRAGRTGPGHCYRLYSSALFETYFEQFSQPEILRMPIEGVVLQMKSMHIDAVTNFPFPTPPDRLSLRKAEVILTHLGALTSSEPGTPMVSGNITDIGKAMSLFPLSPRFSRMLVSGRQHGCLPYVVTIVSALSVGDPFLREEALDQGNDSFDDEDEDLSHLTSETVRAKAARRLQRKAFFQSQQTHSSLGDHASDVFRVLSVVGAYEYAGGGHKFCTEHFVRPKAMEEIHKLRAQLSSIVQTNFPDSDAGLVANLRPPTALQMKVLRQLLAAGFIDQVAVRKDKVSQDASSGQQFTTARGVPYRALGIDEDVFIHPSSVLANKPPPDFVVYLEVVRTSKVWIKGSLDLGLSAARRANVSSLKFVGLTVVNAAWLSSLGKTLCTFSKPIRTKEGHTVVIPHFGPGAWELPPVKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4J1</accession>
    <name>A0A2R6S4J1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4J1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4J1"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000131">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000236">
        <property type="entry name" value="Vacuolar protein 8, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000128">
        <property type="entry name" value="Vacuolar protein-like protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="354"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="10">
        <location>
            <begin position="395"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="633"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS37182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="683" mass="74579" checksum="57E8E56B548DFB6F" modified="2018-06-20" version="1">MVKQGARERSWSQYKALQPRVLRKRECWFPTWHRSFTWAGVYIPTVGIQPDDLFPSTSTFIAQRLAALLLHSRKSQSYEPLLLENEREAVADLLQYLENRTTTNFFSGSPLSALTTLSFSDNVDLQRSAALAFAEITEKEVRPVGRDTLDPILFLLSSHDTEVQRAASAALGNLAVNTDNKLLIVKLGGLEPLIRQMLSPNVEVQCNAVGCVTNLATHDDNKTKIAQSGALVPLTRLARSKDMRVQRNATGALLNMTHSDENRQQLVNAGAIPVLVSLLNSQDTDVQYYCTTALSNIAVDAANRKKLAQTEPKLVSSLVQLMDSPSLKVQCQAALALRNLASDEKYQLEIVKADGLSSLLRLLQSAYLPLILSAAACVRNVSIHPQNESPIIESGFLQPLINLLSFKDNEEVQCHAISTLRNLAASSEKNKLAIVKAGAIQSIKELVLEVPMNVQSEMTACIAVLALSDELKGQLLEMGICEVLIPLTNSPSSEVQGNSAAALGNLSSKDGRATSDDYSAFNDVWGQPDGGMHKYLYRFLTSPDATFQHIAVWTIVQLLESNDPQLISNIRSSNILIPNIRQLAATRTSTPTSSIGGTPHSHGSRHSYQDTDTGEGQGEIQLLARRILDFTEGDDDNIMTPSAPPSQLQVGSLAESRAESMMGRDEELRRSVREAFSGGSTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S502</accession>
    <name>A0A2R6S502_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000067">
        <property type="protein sequence ID" value="PSS37299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S502"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8019" checksum="B99F19D6EB746DFD" modified="2018-06-20" version="1">MIRIPTAIGQGQGKTIQCWEAVFWLLNSVSRAPSAVYGSELVGLHRNRKPRWGTTMDFGFQGNPSSSTTFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5Y6</accession>
    <name>A0A2R6S5Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5Y6"/>
    <dbReference type="STRING" id="98765.A0A2R6S5Y6"/>
    <dbReference type="OrthoDB" id="10261361at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="264" mass="28552" checksum="A17813B5A7300170" modified="2018-06-20" version="1">MTVKDLAALYDSRGPDTPIYSDTDQTSPDISAARRAKFLAHPLLRHNASQPQSYTHVDSLGDHSQQEALNTNDNLTTDTPDPIPQYTSSANGTVAEVETLEKGTCRTHDFGRSSWTIESETVVDGDHHEMKVLSSRGTTITEALPIISPSSTITNNPTVLHHHLGPHSPIAASVVFSRNASPLSFPDLDKNIASLPAPSFPSSVLSAGQDTSIFPPMELLAASGKSLEDLENNSQIPHWWQSRNTLFGAMVSIALSITVRVYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6H7</accession>
    <name>A0A2R6S6H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6H7"/>
    <dbReference type="STRING" id="98765.A0A2R6S6H7"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="461" mass="49290" checksum="6359F7F0E8EA6603" modified="2018-06-20" version="1">MDNDFASAAVRVLFINCMALQSIDALWDRLIDELKNADPKPNKGAKAKKIKETSAQTLERLLAERPSKCVILLDELDHIASSSQSLTSFFTIAHTHRSHIRLIGIANTHTLSSSSTTLHSAQSLAGVRTLHFAPYTPQQLLEILQARLAPLSANEDASTSPSEKADKFLPLPTLNLLTKKVAAQTGDVRAIMEVLRGAIDIAVNTNDAANPLAAPTPSVTPAHVLAALKAYAPAAPTARSAGSSAVSRKTSDSEVVTKVKELGLQARLVLMALVLATDRHSAGLPLSNSHSSSPSPTSTPRSPTKRSQSASSTGDCVDAIQLHTYYKMILSRADDGIFTPVSRSEFIDLLGMLETVGLVSLSSLSVPGTPSKSGKRGLSRCVSFSAVSSKATSHEVRFVEGVRTDEVKRGLGLYEKEAGLDVMAEEVWNVWENERVRIQREARSKPGASPVGEAFDEAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDL7</accession>
    <name>A0A2R6NDL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001355">
        <property type="protein sequence ID" value="PSR70411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NDL7"/>
    <dbReference type="OrthoDB" id="3169018at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="1134"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1408" mass="158130" checksum="9823EB9B2300CB26" modified="2018-06-20" version="1">MTGSCEKLPEQNELAPVPENTANDLSFQPHKRALELWNRFLESQSLQDLEESIRCDREALCLRLEGHPARDLSMNNLGSSLTARYEILGHAEDLDESISLHRATLLLRSETHAEYSTSLNNIATSLLSRFERDGKVDDLEQSIKLHRAALAKRPIDHEFHYVSLNNLASAVWTRFKTERMKEDLNEAIVLYRAAVDLPPELHPCRQMSVDNLVNSLIERFRQNKGLKDIDEAIALQRRAVDASEESQARAAELKILAYLLSLRDGRLENASDMQEAITIYRSVLGLIPNDDPERYASLSGLATCLRDEWEQSNRIQDLEDSIEFFRQALALCAEQDTKCVSAQANLAYVLRVRFEQSGEMEDIEEVIDLYRTAQQSSSDDTERVALLHSLALALHLKFGRTLHIEDLEESIALCRGVLELRPDPDPERPGTLNNLGLSLWELFEQRGRIEDLEEAIHLHRTALSLRPVGDIDRPESLGNLAFSLRTLFEQCGRVEDLDEAIALHSEALDLVAEGSLRAGALNNLATVLSARSRIWQSVDDQNKAVELYREALALCPKKHMNYSTFLYNLASSLCGRYNQGGRMEDLEESIAHDRAALALRPAGHSSRAASLNNLANALSARYTEMGDMVDLEELISLHRETLSLSPRQNPNRPIALTNLGSSLLARFERIRRTDDLDESIEVHRECVALCAEGHHIRALALANLGNSLYLRFDFKKTTDDLEEAISMHHSALDLRVEGNPERSASLYSMALCLGARFQQLAQQDDLDESITFHRAALHLRPQEHPQRSASLDNLATFLLTRFETQGQEQDLSESIEMNRAALALRPEGNAEHSISLNNLASSLLARYQREDTKQDIEEIFVLMESGAEHPYSSVLTRVGIAIRWARLARTYSHSSTPRAYRTALSLMENSLAFSPTLQMQHDVLTNHLKSPALALDAASLFIERGELIEAVEVLEQGRTLLWSELRGFRTSLDHLEKSHEPLATKLRSINRQLENLATTSETQHFGLLTTAEIDVHRIHRRRSFDEMLVMRRHLAEQQVNVIEEIRKQPGFEDFLRPAPFKVLQDAAQEGPVIIVNHCKYRCDAVIVLSNHPPINVPLDSQFYADTTSICKELLQTRDKFNAVSHEYDAKLREVMKMLWDRVVSLVVQKLIDFGVGPGERIWWCPTSTLSAFPFHAAGPFENSDGTSQYLLDEYISSYTPTLKSLIAARSGKIKGRLKLLVIGDTQLPSAAQEVDIIRKYGMPAEFLIDDEASRSTVLDKLAESKWVHFACHGQLDSKPFDSSFKLSDAGLTLLDIARAELPNAEFAFLSACHTAEQPLDGGQDEVLHLAAAIQFCGFRSVIGTMWELFDVDGPAFAKHIYARLIEKPTKGEARFKRSAGALRAAALALKAQDGIAAEGWVNMVHIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE10</accession>
    <name>A0A2R6NE10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v13513</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001346">
        <property type="protein sequence ID" value="PSR70604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE10"/>
    <dbReference type="STRING" id="98765.A0A2R6NE10"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="15">
        <location>
            <begin position="301"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR70604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="454" mass="51136" checksum="9814C94BDFB1F9D7" modified="2018-06-20" version="1">MLPRNVRRLKLSASTPEHIRLALAQRSSLRASIRPVLPYSAQVPPSSSFHTSARRQNEIKSPFQTFVDVLKEELRKNRELQDNVKQLQGDVDKLQDSEAMRKARAAYERARLTSSIKENPRLRAAAEELHKAGVKVGDAVSEALRTMEESEVMRAISRASAAVSSTIEKTTEPIRNTQAYKTLAETVTDALDDSGSAKHAGFEEKEARRKRRQLRLAKAGKDSMTSGTSRVTVNPDAGQALVMHKDSPRQEAWNRMKETNPVLRQLTELRQAFDESEHPVVSSIRSVTQTVGSWFDENENAQVQRLMKAIDPTFNMEGFERELREYIVPEVVDAYLTADHEALRAWCSEATYNVLWAMMEQYLKQGLISDSKVLDIRQVEVMSGKILENDIPVFVVTFATQEMVLFKNAKTGEIIVGAEDKVEQVHYAAVITRVIEDLDNELTGGWKVVETAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEV4</accession>
    <name>A0A2R6NEV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001312">
        <property type="protein sequence ID" value="PSR70809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEV4"/>
    <dbReference type="STRING" id="98765.A0A2R6NEV4"/>
    <dbReference type="OrthoDB" id="3337916at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="1">
        <location>
            <begin position="70"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="33622" checksum="21BA47B4A5C776BD" modified="2018-06-20" version="1">MSSVATNLFPVPPTRIVSGFTTCSLVDVPHVAKVALSDSALGIHKVSSQTSHNIVTPPCPEPVSREAHPRAWEAFFPEGSINPGNKQTAPGGFGFYMQGPGPFHKKLTQETPDEVVMSYEVMFEEGWEWRKGGKLPGIYGGVGESAYGCTGGRQTDRCKCFNLRLMWRENGTGELYAYLPQDAANTAAMLAIPPRSIQHPDYGFSVGRGAWKFVTGKWTAVAERVKMNTVGKANGEIEVFIDGRSVIKAIGLVLRDQEAPSSCVRGMHFQTFFGGHSEDWASPKDQKAWFTNVSGAILRPSAQPRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFJ6</accession>
    <name>A0A2R6NFJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFJ6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="13746" checksum="824FB6AD2E420F41" modified="2018-06-20" version="1">MPVARTPLDISNVKLDRETGKIYVEEFSNIGLAADATEQRWTGLYIRHPDRRSSKLSEGQALALKHEIAKLVTATGAFEQAPSGRAIFRNGTYQTIKDALRVGGFQLTKCDYSGFENCEHPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFV1</accession>
    <name>A0A2R6NFV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFV1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7108" checksum="82ACAB8D35F88E7E" modified="2018-06-20" version="1">MRHLRSTKPEVGRMVASNDRDRGTDNMVAYTEQVAIKEDKIAGDNQEDNGADHAPNERLAPSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG28</accession>
    <name>A0A2R6NG28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG28"/>
    <dbReference type="STRING" id="98765.A0A2R6NG28"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS-like N-terminal" evidence="2">
        <location>
            <begin position="233"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein MutS connector" evidence="3">
        <location>
            <begin position="368"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="4">
        <location>
            <begin position="507"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="80767" checksum="2E7BA3D2A5CDAC20" modified="2018-06-20" version="1">MLKSSQDLARSLRLRSHSNNVILRGIKTSHSICNTTSSTSIASTQPPLTKRAITRTRKSFSELPKTWTNADGTAAIPLSPWIGGLETSLEVSPKENVVSPTDDSANNTPSPSLTDSAAEIAEPELIKPKRTRKKRAAAPAQELVHTDGLDQTLQDEGPSKPKRARKKRANGDGSAQGEAVENVDSELKPRKVKRKAKKQQDSLASECLPEEETVVRQPTSPLATEILDNLVKFPHCILLTRVGQFYESYFEQAAEVARLLNIKLTSKSWGGQRVHMCGFPLIHLNKHLRTLVQGHNRFVALCEEFMRSRTLGPKGGFDRRVTRIVTPGTLIDEPFLNQYENNYLLSVTYPGDLAQPTGDSHALSHKPLGLAWIDVSTGEFFTKSIAYEGLRDELVRIGPKEVVLDNAIAEDTTHPIRKAITEENCFCSYMSTCSAEERDEIIEGQSGSDDLSLQLEPSKALQNLTDAEVAAVKLLTAFLHANLLEYMPRLSSPHREATAGRMQIDAHTIKALEIRESMREGGTTGSLFSVVKRTVTSGGTRLLARWLSSPSTSVIEINSRQSLVAYFYSRPHLRSDLVRSLSDVEDATRIVQKFLVGRGDASDLSAVCSTIDVWSSIKKRIEMERKMEEEENAHIVEGDWASIDALMSRLNSLGDLATTIKAAVGPRNGLLEANTIDVGPDEKSASTEHQFASSLFSDTTTSFNWTVRPESVNVSEINAFHSLTHMIGSLRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG85</accession>
    <name>A0A2R6NG85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG85"/>
    <dbReference type="STRING" id="98765.A0A2R6NG85"/>
    <dbReference type="OrthoDB" id="413649at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.30">
        <property type="entry name" value="Biosynthetic Protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1660.10">
        <property type="entry name" value="EreA-like (biosynthetic domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1870.10">
        <property type="entry name" value="EreA-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052036">
        <property type="entry name" value="Hydrolase/PRTase-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299:SF0">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159501">
        <property type="entry name" value="EreA/ChaN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47337" checksum="8575286D05566450" modified="2018-06-20" version="1">MPVVEKQASSNILARHLHHLSFKPTSYDPLLKAIGNAQVVLIGDGSHGTYEFYAHRANITQRLVEEKGFTAIAVEADWPDAFRINRYIHGGSLKDGPITSAHAALKDFERFPKWMWKNEVMPPFIQYLKDHNAGVLENTGDRSQQVSFFGLDLYSLHRSAEEVLKYLERVDPEGAKAARKKYNCFERFGEDTTRYAYEAQFGLAKTCHKEVVQNLRSLLKNHHKYIEEQLPDGDDRYGHPAEEQFMAEMNALVVKDAEEYYRTMMTEDEKSWNLRDDHFARILNRVAHHLGTTPEGQRKDAKIVVWAHNSHIGDARATDMGRRRGEINVGQRCRELFGDNNVFNLGFLTGRGTVTAAYEWDDDPELMTMNAPLDGSLEHLLDSSSTEDSFLVTHSIEDTSEGETIKVEESDELTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGR9</accession>
    <name>A0A2R6NGR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGR9"/>
    <dbReference type="STRING" id="98765.A0A2R6NGR9"/>
    <dbReference type="OrthoDB" id="3835061at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="191" mass="20656" checksum="043EC45E69ADCDC3" modified="2018-06-20" version="1">MDLAFAPDGGYFFIHPKGHKWHGLVPALVEKLDSLKGDGKKVNGSYFLEDSTGSRCWNFKGNYSSLQEYVKEHTFTNVATVNLSPFNGLHYFVTFKNSHAKWNLPATWAPDIREVAKQYQHQNASSSGGTADSSSSGHNASRPHKHRSSSSAASVMADVEDGLEMTEKIVKTAGVVISTTGMVAGAGCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH45</accession>
    <name>A0A2R6NH45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v12420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH45"/>
    <dbReference type="STRING" id="98765.A0A2R6NH45"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="283"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR71716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="347" mass="39637" checksum="847B947311412E50" modified="2018-06-20" version="1">MDVDAPPIIPLEIRRPTGTYRLSDFDIHRTLGTGSFGRVHLVRSKHNLRFYAIKVLSKEKIVRMKQVSHTRNEQMMLQAVQHPFIINLWGTFQDSTNLYMVMDFVPGGELFTLLRRSNRFPDPVAKFYAAEVALALNYLHNLDIIYRDLKPENILLNFDGHIKIADFGFAKYCNNTAWTLCGTPDYLAPEIIGNARYNKSVDWYALGVLIYEMLSGLPPFHEPDASPVVLYEKIAQGPTCIRWPAFNTNATDLILKFMERDPSKRYGNLRHGAGDVFAHPWFREVDWERLKNREITAPYLPRISGAGDASAFEKYPEDNIATAAYGVSSADEFGDMFPDFEYTSHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHT5</accession>
    <name>A0A2R6NHT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHT5"/>
    <dbReference type="STRING" id="98765.A0A2R6NHT5"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="6">
        <location>
            <begin position="578"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="652" mass="74075" checksum="8EAA0C9C31287DDA" modified="2018-06-20" version="1">MVRNRNAKRNNNSHPRPVDRKEGTLKRWNKPSDIPMDEEDQFHASRDRILLEGDDVHSDDEGDEEEVFALKGIPDSEEEDEGEVGSEEDEEDEDETPLPSAATSKKPSGKQRKQAPPSSDEQSDSESEEEGWGRSKAAYYSSNAAQLSSDDEEANEMEEQEANRLQAKIREVLNDDDFGLADVANIVMEQEDDGDEPVPVITEVLPKDKESLLRHLERTNPEALALARDWDDVARTLVKTQEKITRLEDEQSDAITSGMLHLYYQALLQYAITLAFYLYLRSSEQYSVHPEQLRSHPIMGRLLTLKQHIATLEDLDVAGSEEEDEDDDEDEDSDNDLAAIRFPKKWGAEASDELLNLFEEMKQFRGADEPPIKKEKKKARVPLEEPPKKKRKTTPASKPAPSLPIFDLEEPVFPAKSKPTTRPSSNTDADAYGEQTTLQAADAADKAARKRTLRFHTSKIESASARRERARANAGGDDDIPWKERKKEREERQKRELEKSRTTAGNDLDEEEPESREAASKKRRRDEGDDKETEQDDAEGYYDLVSRKSKEKKERKKVEYETEQSLVREELRVEDIADGPRSVSRAIMKNRGLTPHRSKSVRNPRVKKRQRYEKAKKTVASQKAVYKGGVGATGRYDGEKSGISKVIKSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHX4</accession>
    <name>A0A2R6NHX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v12194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHX4"/>
    <dbReference type="STRING" id="98765.A0A2R6NHX4"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="9">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR71984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="23566" checksum="9D4D77C3EBA91D58" modified="2018-06-20" version="1">MSPVKYFLKCHRTQMQHKHFNTLLNNLKMASSQPDHLSSPLGYAHKHLVDSFYASDNPRDKDKIRVTRDEKTGTVIACMRKVRLGNLDIYSPKRAADWRISVNLEIPVPPPIGSTTHTRKKDRMSYTHEEFVIDLTQVTSNAGPNTKPEILHELEVELARPEYVLSAATKRGDPNVSEAERSAFDHLIHAFVNNARILVRNSGEGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIB2</accession>
    <name>A0A2R6NIB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIB2"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="248" mass="26475" checksum="290C5032F5594B52" modified="2018-06-20" version="1">MPIVLLGAVYYLPVYFQAVKGSGPINSGVLGFGLALTTAPFGILFGASVARTHRYRPQAYLCWSLAIIGAGLLTLLKVDSSKSMAAGFEIVLGIGLGGISTLTYFPVLSPLPVTQNAQALAFFAFTRNFGQIWGVTIGATVLQNGLVHKLPSSFIKEVAVGGEIAYSIIPLIPTLNAGLRQEAQEAFTDSLRVVWQVLIGIAGIGLLASFGMAHVPLHTHTDEDWQMEQRKSEVDSELLKQSSKDTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIH3</accession>
    <name>A0A2R6NIH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001206">
        <property type="protein sequence ID" value="PSR72195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIH3"/>
    <dbReference type="STRING" id="98765.A0A2R6NIH3"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="404" mass="45655" checksum="C9357DDFC3E0ECDE" modified="2018-06-20" version="1">MDVGERKTAMLVNNGVKHPPVLTSGILTPEIIQQFQITCQHHFNYRKVADPDKKYREAWKTLLQQHLAAGRIRPSSSPHASPAFLIPKADPVVLPRWVNDYRKLNANTVPDVHPLPSIAEILSDCGKGQFFAKIDMTNSFFQTRVHPDDIPLTAVTTTFGLYEWTVMPQGCRNAPATHQRRMFNALRDHIGSICHVYLDDIVIWSQTLEEHRQNVATILKCLRKNKLYCSPKKTDLFCLSINFLGYYISANGIEADNKKVEKILDWPVPRSAFDVRSFLGLVRYISNFLPALAQHTLVLNTLTTKEADKDFIWTPAHFDAFEAVKTLVTSRECLTVIDHINMGANRVFVSCDASDRCTGAVLSYGETPETARPVAFESQQLSGVELNYPVHEKELLAIVRALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NII5</accession>
    <name>A0A2R6NII5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v11998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NII5"/>
    <dbReference type="STRING" id="98765.A0A2R6NII5"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR72150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="336" mass="36639" checksum="ACC2C6943E41A391" modified="2018-06-20" version="1">MSTQQKQYEYILLSRPAPGVGLITLNRPKALNALCTPLFKELNEALVDLDADDEIGAVVLTGSNRAFAAGADIKEMKDKTYADVYKNRFLENWSEMTALSKPVIAAVSGYALGGGCELALMCDIILASPTAVFGQPEINLGVIPGGGGTQRLARAIGKSRTMELTLTGRNFSAAEAASWGMVSRVVEEGEGKVVEEAVSMAGVIASKGRLAVQAGKEAVNAAYELTLEEGLKTERRIFHGLFATHDQKEGEHGCIELWGHSWLMRVAQACPLSQRRGNPLGSIHRFATVKPDPRKQLYTIHNEPTAYRRHDMLRIEGGRLNLSYGYYDYPGISYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIK0</accession>
    <name>A0A2R6NIK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIK0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="11713" checksum="79BCA75A5A329A52" modified="2018-06-20" version="1">MKSVRKGVQEAGARRGEQAFPLEEDITPGPAESQTEEIAGRLFGLIEISSGDPNLETVDCFFGGLGGLFVRKRCGFNPENPTWDVLLCNCFFNPSTILPRGFFLVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ46</accession>
    <name>A0A2R6NJ46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ46"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ46"/>
    <dbReference type="OrthoDB" id="2684839at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="16122" checksum="0710946F26381E86" modified="2018-06-20" version="1">MDNSAILELAKAWPALSTLRLGSNGSRAVSRITLRGLDHIIKHCRDLRSLSIVINAQDPPTVLDDMPTCCNKRITTINFADSLLSNPSDVVAYLSVLFPGLVEIQTHRNLDMETKDLWRQVTTMIPAMRRAHEARSRLLELESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ68</accession>
    <name>A0A2R6NJ68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001187">
        <property type="protein sequence ID" value="PSR72427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ68"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ68"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17658" checksum="4464022BCD8B06B0" modified="2018-06-20" version="1" fragment="single">IGGGVLGDCWRPEERGKAVALYSLAPLLGPVVGPVAGAWIAERSTWRWVIRYPYSSGRQVSWTRSSKFLVCSSCNLRRSPLLMERKAARMRKEMESDPEKATAREIRTRFDHSDRHWKQIFAKSLVRPFKLFWYEPIAQLLGAYMAFVYGLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ87</accession>
    <name>A0A2R6NJ87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001188">
        <property type="protein sequence ID" value="PSR72426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ87"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ87"/>
    <dbReference type="OrthoDB" id="2797645at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF25">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="295" mass="33038" checksum="9984B42981D41B07" modified="2018-06-20" version="1" fragment="single">MYQLRPDDVETISPARFGPYWRPKHATEIAEDKDSAKEAEKKWRRKDGIRVYTDGSDVGGGVGAAAVLYKPGQKRVKTLQYHLGPSSRHTVYEAEVVALILGMELIRQESKVRDVSLAVDNQAAVLSSRASKSAPGHYLMDKYHQMQARAVKKHPNMRITVRWVPGHMGIKGNEEADVRAKEAAKGEMEVCRPIPAILRKELPQSISKLHQGRSEELKAEATARWRNSPQWARMNEIDPTLPSKRYSVLIAGLPQRHAAILFQLRTGHAPLQKLLHKIGKADTPMCPACHEAPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJH0</accession>
    <name>A0A2R6NJH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02001159">
        <property type="protein sequence ID" value="PSR72535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJH0"/>
    <dbReference type="STRING" id="98765.A0A2R6NJH0"/>
    <dbReference type="OrthoDB" id="2499463at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="59"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="273"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="512" mass="58132" checksum="4D13968B6C5062CF" modified="2018-06-20" version="1">MPMPTAAKTPCPVSLLAKTRENAERTGNYSSAHTRQLVTQEIKKRCDGKTPYGWQLDVAEALLLRLDSIVIAGTGAGKTLPFVMPLLADQTDNKKIIIVSPLDELEYDQAERFKKMGIRAAAVNSQVWDKQLHKDILENKYQILITSPEMLLEHTEFSKLIRAADFMKDVLCIIIDEAHCISQWGSDFRPKYGELEKLRSYVALNVPILATSATFTPTVLADIQIKLRYSPERTYLLNLGNDRHNITPLVIQMKGAAKDFAALDFVVDEAFADPPQALVRTLIYVNSKDLAHDTWAHLSNQLPTHLQDQIAYIHAGRSPRAKKLTMEQFRNGKIKILCATEVAGMGLDIPDIDRVVQYMLPKTLNEWIQHYGRAGRNGQPAIAILLVEPSAFKLRKIKIKKENPDKSTSANTRGKRRIPIEDAVDNTDLDEDEHQINDTDELSHDVREESKIEAHLAYQKQVEDGLRKWLDTILCRRVIQDEYFQNPPACRRMQFILCNNCLRVIMILTVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJQ9</accession>
    <name>A0A2R6NJQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001152">
        <property type="protein sequence ID" value="PSR72609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJQ9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="7153" checksum="0DCE89BA3BF1FC61" modified="2018-06-20" version="1">MQNVVRIIIRAASKNELVELMDVQIGFRRGGAHYQIWHSTDAAALNTNFYYNPIFSKTLKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL21</accession>
    <name>A0A2R6NL21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v11185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL21"/>
    <dbReference type="STRING" id="98765.A0A2R6NL21"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="7">
        <location>
            <begin position="330"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR72948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="591" mass="64763" checksum="5A64155C9A330931" modified="2018-06-20" version="1">MLSSPTPPPGSRVIATNAFRKAGLMDHDERMRDASDKPGGRKGHQKTNTHKVRSHRPRAAEAVLGKDHPSSSNRNPMLAARIAASSSSEGLAIRGASKATTAGRLRRNAISLNGSSSSNVVNRATTVGVKVIELWKEFVNLRWNPEARFLNLERMLDDEFIAKNRLIPPGAPGSSTKEASVIFKIAGQLKPDVQTISLAHNNIGNGVMLTTMAHYLPKLANLSLEGNKLKMWRDLDYISGRKGKLEHLRELILKGNPIRELEYQNNRAHKYKSELARRFPSLEMLDQEAIVKIAFDVPQASTSGTITRTTATTFPAPMMPPFITGVDGSIVSNFLMRYFPLYDNQRSALIDAYHPSATFSFSANTAIPVRARIEGYHYSKEMPNQRKLEWPPWLLGGHGGSRNLSRMAGGGQRLTKTLHVGGEEAVKAMADLPSTKHDVSGSPEKFCVDAWPVTHADGTALFITLHGQFTELPSEGIRSFDRSFIVAPAPDGSRVLLPKFLTGLCRAKLNGWDVMIMSDQLVVRAYSKHEAWQPGPMRVQAGDSLPSDTPPSSVPSLTPQAEAQLQQDLAAIVSCKFHQSKGYAVSQNLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMQ1</accession>
    <name>A0A2R6NMQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMQ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NMQ1"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="61"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="156"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="270"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR73668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50297" checksum="CDA1A9F53A0153E2" modified="2018-06-20" version="1">MASHPIVELTSPSSWAMVEDKFSPYAKETLAKLISFMDNEVLPALRVAHAQVPTDPETRWKTVIPIVKDLKAKARKLGLWNLFLSKKHYPKFGVDLTNLEYAVMAEVLGRGGQFGSEAVNCSAPDTGNMEVLARYGSPEQQEKWLVPLLNGEIRSAFAMTERFVASSDATNIRTSIRQDGNEIVINGHKWWISNAGDPRCALHLVLGKSDPNNKDRYKQQSIVIVPTNTPGVKIIRPMKVFGYDDAPEGHCEIIYDNVRVPLSNLVLGWGRGFEIIQGRLGPGRIHHCMRSIGLAQMALDLMIERVTDPTRKTFGKYLYEHGTVVADIARSRAEIESARLLVLSAALQIDKFQAKGALKEIGIAKFVVPSMALQVVDRAIQSFGAEGVSQDQVLAATWAGLRTLRLADGPDAVHIQQIGQRELKRAPGILKRHAEIKQKEKQLFEKYGVKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMW4</accession>
    <name>A0A2R6NMW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMW4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9860" checksum="683564AFFA6D5185" modified="2018-06-20" version="1">MHVTISAVLHPGLVLDHQRSRIIRDVRLRGALPPPMDQDTDDQSPDNGSAIQKVFSLAFASASPEDTPYTRQPWSPSPSNAVYNDQYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNE8</accession>
    <name>A0A2R6NNE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001047">
        <property type="protein sequence ID" value="PSR73933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNE8"/>
    <dbReference type="STRING" id="98765.A0A2R6NNE8"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="288" mass="31972" checksum="90BD82706895E96C" modified="2018-06-20" version="1">MSVSPTMHISYTLLPSDPSRNDEPNMSYAEEHKTSVELKTALINRALEETGMGRYQWCIFFLCGFGYALDLMWAQAFSLVTPRIQQELGVAGVIITSLISWALIPKFACTPNLPACTAVSDPSSITCCTKSSNYGWRYALFVIGALSVFAFIARFVLFSFHESPKFLVSKGRDAEAVEVVKAVAKFNRRSCVLTLQDMEDCERTSASDSDESLRGGGGEVAEKKAKKIRVGHLTTLFSTWSMTRLTILTWICYAADYWGFVIAGNFLPKFLADRGAAANESTYDTYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNH8</accession>
    <name>A0A2R6NNH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v10323</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001055">
        <property type="protein sequence ID" value="PSR73854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNH8"/>
    <dbReference type="STRING" id="98765.A0A2R6NNH8"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015360159" description="beta-glucosidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="17">
        <location>
            <begin position="115"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="16">
        <location>
            <begin position="269"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="18">
        <location>
            <begin position="674"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR73854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="888" mass="98545" checksum="EA8CE7B69B9BA20A" modified="2018-06-20" version="1">MKLSIIVCAVVLTRSVWATVTNPKVLDGCPGYKASSINSEGSKLTADLTLSGDPCNVFGADIETLSLEVTYETTTRIHIKITDASSTRYEVPETVFPRPAISPSVSAHNAEIRFNYTASPFSFSIYRSSTSEVLFSTASHSIIFEPQYLRVKTSLPDNANIYGLGEHTDTFRLPTHNTTRTLWSRDAYGVPTGSNLYGNHPIYFEHRTTGTHGVFLLNSNGMDIKINDTDGTSLEYNVIGGVLDFYFLAGSTTDPTEVARQYAELVGTPAEVPYWSFGFHQCRFGYLDYLDVAGAIANYSAANIPLETMWTDIDYMYNRRIFTVDPDYFPLSRMREIIDHLHSHDQKYVLMTDPAVAYLPGEGYGPFDRGSQMDIWLKAENGSDSLGLVWPDWFNPQAQDYWSNEFELFYNPDNGLDIDGAWIDMNEPSSFCNYPCTDPFQQAIEQDLPPSRSTPPPDPNAPIFGQIASAQVNMMALRKRVDHTGDDLLNPPYQIQNDAGIGVLSDRTAYTNAKHANGLVEYDTHNLYGTMMSTATHNAMLSRRPGLRTVVITRSTFAGAGSRVGKWLGDNFSQWDHYRASIAGILGMAGVYQVPMVGADICGYAENTTETLCARWAMLGAFYPFMRNHNDAASISQEFYRWSTVAQAARNVLDIRYRLLDYIYTAFHEAHLDGTPILNPLWYIYPQDRSTYPIDLQFFFGNSILVSPVTEENSTTVSAYFPDDIFYDFLTLAPFQGHGSSTAVDNVNFTSIPLHIRGGAILPLRETGAMTTTALRNTDFEIIVAPDTHDQASGSLYADDGVSIIPKATTQVQLSYAKGNLAVKGSFGYPLGVNVARVKFLGVNETPRSVKVDGVDVKPGSFSFDKSSQVLDVALQIPFIQAFTVQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPH4</accession>
    <name>A0A2R6NPH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000994">
        <property type="protein sequence ID" value="PSR74347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPH4"/>
    <dbReference type="OrthoDB" id="1917726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17669" checksum="B52BF7C14CE92570" modified="2018-06-20" version="1" fragment="single">MAKCLQSLGNIHSMQHKYEIASQVLKEAQTQSAAIGDKLGVAQCLQSLGDIHRMQHEYEIASQALKEAQTQFAAIGDKLGVAQCLCSLGSIHRMQHEYEIASQVLKEAQTQFAAIGHKLGVAQCLQSLGNIHRMQHEYEIASQVLKEAQTQFAAIGDKLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQX1</accession>
    <name>A0A2R6NQX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQX1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="148" mass="15414" checksum="F1432B8FCD77C190" modified="2018-06-20" version="1">MEQNTANTNTTSPTTSPTNPESVPPLPPKSRARPRSNTVFSSPSSPVLYWQTSGPRSRTVTANAATLAKLQTTSGVPNGTTPSLPENDKAANAPILEDDKAVPNSPDSLDASTPTVTNPYPGKTPTQESLTEDAGLMLGKSSGLPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR53</accession>
    <name>A0A2R6NR53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000936">
        <property type="protein sequence ID" value="PSR75070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR53"/>
    <dbReference type="STRING" id="98765.A0A2R6NR53"/>
    <dbReference type="OrthoDB" id="2989020at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="21180" checksum="69DA1199A80AF345" modified="2018-06-20" version="1" fragment="single">SMGTRDTSQAPEPEPESVGESQADDAQAEVPVDGTIDTETPDSEPDKNEMITLQLNPGGQLYAKSQVTDYSLQGTALEDYDVHDFFTNTYEASMPKPPTADANDNRELSDSDNEPVHPARRGRSPNMRSLYHADHPHAMIKLRVVHTPLHWHIINYVGRFFPSKDDPTTYPFYCASMLPLDICGVFWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR82</accession>
    <name>A0A2R6NR82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000922">
        <property type="protein sequence ID" value="PSR75164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR82"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6989" checksum="61CF5EF6839F7E5E" modified="2018-06-20" version="1">MHDAQYGNDESAPSPNSTTSIESEEADEDFARRILAAKREAKKKHKCSICGRAFLRYSISNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRQ3</accession>
    <name>A0A2R6NRQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000893">
        <property type="protein sequence ID" value="PSR75470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NRQ3"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="14458" checksum="1F70FFB5B52BA409" modified="2018-06-20" version="1">MDDLAKGAGGGYRYIFSKAAPDIPRKITHALLLRSNGIISTAPLGWDLITVDINKGRRKSYLYILAKTVATETSSKAFLNVPSVGGYLTVRSNTPKQYVQALNVCYGDDLSDLPADCVGELNGLSADVNFQCGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRY9</accession>
    <name>A0A2R6NRY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRY9"/>
    <dbReference type="STRING" id="98765.A0A2R6NRY9"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="25871" checksum="4AB78A10EBF057CA" modified="2018-06-20" version="1">MQLIGLAARRATAVRSGTLRAVSSATRSYATGSPVSLKEEQDPQLGDYPTLPDISKQRRPARGWDDPQMRRNFGEPVRKLDDVASQGIYSLFRLIQLHFKEEMYSMWGPDAPVVPPAQALRQFTIVTIGFVMFGFLCKAIVPESPVARRQYPFSGLVTELGGLEENKVRSTRDYKDLGYFQLRLAGEITRRVRRGGLITPYNFTIVPLPNTNGISDTRDSSRLSTMCSLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS62</accession>
    <name>A0A2R6NS62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS62"/>
    <dbReference type="STRING" id="98765.A0A2R6NS62"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="270" mass="30589" checksum="32A310A8045F836B" modified="2018-06-20" version="1">MEKRGIREQIVVATKFTTNFKRGANIPQKTQFTGNHTKALHVSVEASLKKLRTDYIDILYLHWWDYTTGVEEVMNSLHNLVTQGKVLYLGVSDTPAWIVSKANTYARLMGKTPFVIYQGAWSILQRDFEREILPMALSEGLALAPWNVLAAGKIRSNAEEEKRRETGEHGRKIFGDWQRDENQRKVCDALEKVAQEVGAKSITSVAIAYVMQKAPYVFPIIGGRKVEHLHSNLEALEITLTPEHIAFLEGVQPFDKGFPQNTFVSQFSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSN2</accession>
    <name>A0A2R6NSN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSN2"/>
    <dbReference type="STRING" id="98765.A0A2R6NSN2"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR75922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25583" checksum="80A7D2B90115880A" modified="2018-06-20" version="1">MAPVGFFTLAMGRLLRIETLTLVKILAVMTSFGGVILVSLADSSPGSQGKDGALGTASIVGDILALLSAFFYALYVILLKVRVRSESRMDMQLFFGFVGLFNILFLWPIGLLLHLTRIEIFELPTSSRVMVAILINMSITLSSDYIYVLAMLKTTPLVVTVGLSLTMPLAVVGDFFLHKPVKFQVILGACIVLLSFVAVGIEDSRKGETDLISGKPLDEESTHVRLEEEVDLVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSN4</accession>
    <name>A0A2R6NSN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSN4"/>
    <dbReference type="STRING" id="98765.A0A2R6NSN4"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23100" checksum="54DB23E0E6DC991A" modified="2018-06-20" version="1">MNDAKCVLVVGATAGIGRALALAIHDLPSKPTVIVAGRRQERLDELCPKSERIKGVQVDVTGGKDSLKEFSTHVTTHYPELDAVIFSSGIQHLFKLEEPETIDLDLFETELVTNYTSVITMITYFLPQFLKLSEKGRPSFIVPITSVLGIVPGPWVPYYSATKAALHSLSLSLHTQLKDTQVNVMEIFPPLVESELHDRKFKLPIFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT18</accession>
    <name>A0A2R6NT18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT18"/>
    <dbReference type="OrthoDB" id="2960209at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015356306" evidence="2">
        <location>
            <begin position="29"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="21990" checksum="AC948F52952BFB6C" modified="2018-06-20" version="1">MHNWHHHNWHRGPSRLIWFVFGAAAATAFIRHREAEGFAVRHCSRHRIPQDAYPPPGQEQKVVDAWRWNANASFPKYPAQPPAAATAAPAESAPAHVPMQKPADGQWDEEKQRLQRISEQATETLTSLSEAGLDSLLSTVESLKAKIAERRAQREREVQEAQAARDEKFRQFEEWKKQQEAQEAARKPRHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT81</accession>
    <name>A0A2R6NT81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000858">
        <property type="protein sequence ID" value="PSR76214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT81"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="8289" checksum="E296F41422A45A84" modified="2018-06-20" version="1">MSLGRSKPAGPMLDAAPPDGDAPHAEGVLLQTTGDNGFVIEPFVGPAPGAVFVGATSESGAVLVELSSLELSSTEDLDVRGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTA1</accession>
    <name>A0A2R6NTA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000851">
        <property type="protein sequence ID" value="PSR76275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTA1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="14817" checksum="52BE4AC302903CE8" modified="2018-06-20" version="1">MIDHQSDPINPSSRSAPMKIRVEVILLDFIQYGLTLERIKAYDWVAFDKIASQMGHLQAVVMDLWSEEALSEFIDEVVRPKLTQLQCLNKLKCRCPHPNDEGKWTGDQLQEHIAAWVDDSEAGLLQERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTD6</accession>
    <name>A0A2R6NTD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTD6"/>
    <dbReference type="STRING" id="98765.A0A2R6NTD6"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="102" mass="11499" checksum="FC368C029887EDC5" modified="2018-06-20" version="1">MAIGWGNLNGAITSNVYRAQDKPWYRLGHGIVLAYIAIGWLCSLSFFLLLRKENARRDAGQRDEVLEGVDNPNANDKNGHFKDVQEAGLEKGDQWSGFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTT2</accession>
    <name>A0A2R6NTT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v8430</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTT2"/>
    <dbReference type="STRING" id="98765.A0A2R6NTT2"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR76527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="16934" checksum="AC3FEA6B386B8F1E" modified="2018-06-20" version="1">MISVFYFFPPLVGFNVETVTYKNVRFNVWDVGGQDKIRPLWRHYYTGTQGLVFVVDSQDRERIDEAKQELHRILSDREMKECLLLVFANKQDLPGAMSPAEVTEKLGLHRMRDRSWYVHPSCATTGEGLFEGLQWLSQNVKKRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU69</accession>
    <name>A0A2R6NU69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU69"/>
    <dbReference type="STRING" id="98765.A0A2R6NU69"/>
    <dbReference type="OrthoDB" id="2684446at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="841" mass="90697" checksum="D4F77FFCEF56462F" modified="2018-06-20" version="1">MYSGNGYYYPPPSAVHDENSLAFVQNRQVYGGAQYSSSRLVYLGPPPQDLQYPQDFYPQSAYPVIPVPPPVPQYHPKTMKHSKHSARPMPQSLLDDPAFSTDPRAHPHFAMNSREEIVPADQSSYSDNSYRSRETSRGDPSFKRGLQATPGATYGHLPDHSEVIGGNSQNIRPTSEVSSYSYSSYPGSSQDPRASSGSIGLAYDDPHDDDAYNYSYASSSKSKLHTPKTPISSASAAFGPPTNLSQSPYAIFTPGGSPSSASSRSSSPLVPRTPSPHSGSPSTSTKKLKSSSSLHLHNPDEQEIEAPPAYTPLPTPVGLSFDIPTSAPAGASSSLLAPTPVPVPAPSTSADVLNIPTVFPTAPVRPPLATNTSAPELRPAPARDVPVRSATTPAKAPQPLPETIKMQRSRSRKTSMSAPRDLDKIDELDETDPLGLAWHHESPYEAIQKAGVGRQSGPSGEPMRGVPKIFAAQNGVDPSQSQSENRKPSSYRKPVPVDPNVTNFHVKPGQLFPSIVPSSQTQSVPQQSQFQSPPFPIPYSQDSPPQFPQGFTNSHMHPGSNRPAQPMPNYAQGPPPRSSPIVDQTQPRSVSDNARPSPSSHSSSGSVGHGHSPSQPPLRSQISSASLARSRSAPNNRQPVLSSEPPPRPDIDLPPQRDPQSQQMPTFQPHYLPKRLVMPTPLQPLPQQSAPSNLSGQSANSSFIAPSYTGDPRDGLMEGQNDSGTSLKYSASVPTRAKAQDIPMSSGRNLLRKHKEKSENRKEEKRGGVSIAGITIIPGHAPSAKPDAAVFTSRVVMGESQRPVGRGGREAGLERIREKERERERDRDKEKEKGRKLSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUH9</accession>
    <name>A0A2R6NUH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUH9"/>
    <dbReference type="STRING" id="98765.A0A2R6NUH9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7618" checksum="EB4A111947C8AE1A" modified="2018-06-20" version="1">MPRAFHIPGVIFLFCAFVLLFLVSVSLPYLPALDIARVHFSGSSSTGDSTQGQLTELRVSFTFTFPPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUL9</accession>
    <name>A0A2R6NUL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000833">
        <property type="protein sequence ID" value="PSR76851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUL9"/>
    <dbReference type="OrthoDB" id="10598423at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="13794" checksum="E14F4E5665D3BDB3" modified="2018-06-20" version="1">MNVAQVLVNTVPSMQDASPVGNIIPILEPILISRFMLNLRQLGEPDNETEDTSNSKPSALLFSGPRFRAPTTMASIIGNMGEDLHYGPEELDADNLFEEANVGGSSEEAIMDAAPGITSHEIAQALEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUY0</accession>
    <name>A0A2R6NUY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000807">
        <property type="protein sequence ID" value="PSR77222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUY0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="265" mass="28749" checksum="67E972FA0627770A" modified="2018-06-20" version="1">MAKTVQKKKAVAVAPPPRLSTRAKNASAHPGLVDLSEDSDPERTQRNSKRKAVRAKAKKVKEKKGQNLAEMEQLILKLQNEIAKRDAEVVNTRVECPNMPVDPEDSELVHPMPASSPIEETEEPVVPPSSPIEEVFDADVVMSDGRAESASYEPSRPGSPFQADIDFNAAASDMEAEETDVDESDVPMIPGGPLRRTNAAFFGRNHQGGVVALDRTPSRNSYALDKLPKKQNQPKKRKATANEDDLPEAPCSSKAAGKKVAKPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV57</accession>
    <name>A0A2R6NV57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-asparaginase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000795">
        <property type="protein sequence ID" value="PSR77397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV57"/>
    <dbReference type="STRING" id="98765.A0A2R6NV57"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="4">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR77397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="221" mass="24056" checksum="BA203C6053C06909" modified="2018-06-20" version="1">MEISQPSDESKVLIIYTGGTIGMLVGHQGYVPEPYFLTETLHSQHRFHDPLEESLFSHSASVEGFRSWSGRASPAPSPRGSTFSSRPPSPTPGPNYPATLLVRSSRPIGAPIPLAPTASSSQYSTLRHPSCRKVADDVYEASLQSLVTPRTTANGLNNWIRIATEIELNYSTFDAFVVLHGTDTMSYTSSALSFLLEDLGKTVVRISTEIARDTTNSGIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV69</accession>
    <name>A0A2R6NV69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV69"/>
    <dbReference type="STRING" id="98765.A0A2R6NV69"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="263" mass="30099" checksum="CFD125244EF855AD" modified="2018-06-20" version="1">MSFTNSYKPPPPAAELSQAELYGPDPYDINFTLPLHLPSLETERVKLQPFIPSIHAKHYWEKASEDPDLFRYYPVAHPTLESYLTYYETKVRADPANTLLIIIDKTKPDPEHPEYDGGSLAGALGLFYTSADHLSTEIAYVVIFPAYQRTHVASNAIGVLMRYCLELPTATPQGLGLRRVQWCAHDKNLASARLAERMGFKREGIIRWRWVLPEVLARDGMKPSENDKYPTRYGRNTLCLSVCWDDWESGVREIVEKNINRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWI0</accession>
    <name>A0A2R6NWI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWI0"/>
    <dbReference type="STRING" id="98765.A0A2R6NWI0"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="129"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="36611" checksum="63EFAA3CB6C14403" modified="2018-06-20" version="1">MYSLFRPLLLSGLRPGLAARGHAPLRLNRPRPLHASPIQRSSNHDPGEVSVDEEEPIRLEDEGEYEIILPLDEFSTAKAIRTVPTRIQRPPYALAENVRRFKETGDFEQGYRWSEYDGRIMVGTVEERKLRRAADLARRVLRYAGGLVQVRAQKFMFYVPRFISLSKEGVTTDAIDAAIHKFIVSNNAYPSPLLYKGYPKSCCTSVNNILVHGIPDDRPLRNTDIINIDVTVYLDGFHGDTSKTFLVGDVDRIGRDLVQTTEEALEAGIRVCGPGRPYRGIARAIHGVLQGKDFVVCPAFTGHGIGTVFHRPPWIFHDGKQGTATVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWX6</accession>
    <name>A0A2R6NWX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000724">
        <property type="protein sequence ID" value="PSR78792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWX6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="422" mass="48111" checksum="29C28C5094EBBE66" modified="2018-06-20" version="1">MANVVQVPELIIHIVENLASSTRSLLACSLVSSAWYLCVRPYLFATVCLRGQRTPLITRIPAFLACIKPTNSIGQYIQTLLFREGQRKDPYVNSTVLASLFPHLPCLHSLYLIDIAFKGAEIPLPHLEPPRKIRSLSFRFKASESYTVQHVLDILGLFSHVDELRLSSDDPEGDEIIRGSEGNPATSVHVPGQPFTISKFILNPGMHVYNSMLVRLGETRSVLIEYLDVGIFVRNDLDWEDLGALTRNNRATIQTLIFKPRNPWFEPPLIVLRRPFLYMHRNLPNLQSLQSFTLHHEILNQSELHFPKIWALLSASLLELPISLHHIKLVLLPRMHPLPEVILSPIKLWSRDGLSWEVIRKAFDRLTALETATFINDGKFLPTPHPRIHHDGVLEKIKAELSQLARSSLVIRYETVERQCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX44</accession>
    <name>A0A2R6NX44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX44"/>
    <dbReference type="STRING" id="98765.A0A2R6NX44"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="74"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR78994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="329" mass="37223" checksum="DC0E2254BEE35B2B" modified="2018-06-20" version="1">MIRTSSIHSEAGDPFAAILRPPDGETDYDRQLRLKREAEAKRISDSIDDELRKDEKRYKKRKEDVKLLLLGQAESGKSTLQKQFQLMYSPNSLEEERLSWRSVIYYNIARPVRRIFEVIDTYGDGDSDDDSTAEEHQEHKGPPSESSLSGDQVSSSDKQLASLRLRLSPLLSAESSLSDRLSGGTPVSGGTSKGNLFVRSGWQARALLKSKFRDRSSFTGQRSSLENAMPRKSEDSGMVIGEKDQLIEEVANILYACQDDIKELWDHTTVRSLRETRKLRLEEWAELWVIYVLLIGIFVITSKLIVCVRLVDKTDVLLSKLANGVNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXH0</accession>
    <name>A0A2R6NXH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXH0"/>
    <dbReference type="STRING" id="98765.A0A2R6NXH0"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="44"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="779" mass="87409" checksum="6564477A20013FA0" modified="2018-06-20" version="1">MSSGGEDETLAGIDKVGVLTCYVKLAGANISQSPSNASSGLAGWSAIEDYMRRHDHNMMKVFVEDMDTLLVFAGLFSAVLTAFVVESYQLLQVDNIERSAQLLSKISSQLGSFENAPPFLNSTTSSESLSSSFNPSTSARWINILWFLSLVFSLASALFAILVKQWIREFLQWDSTLAPPRENVLVRQLRFEAWNVWRVPAGISAIPALLEVAVVLFVLGLVVLSWTLDAVVAVVVTIAAAILLLVVCAVTILPAVFQHCPYKSSTGWACVIVFDAFMWSIRYTSWLFARFWLYIRTSCYHLDGMDQNAQNKSIPQFLRFQGWRQRDLHTDGLGSRGDLLFADVGVSDLDSETGCVNHRHLMQNIFEVMPLVRALTWVKKASKDARLLSHVARSAECLHRDGLNIRERYYTVLYMLRKLCTAKSEKLKPLSDFLDGLRSTAYRTVKELALEEDAFLFRGGVPHHLNDYLQLSVHPVEDYATQLWVLAHHLLGDTLTSVWAELKDPTITREVVVLLCLLRDFTAADVWRNTSFGFLEECRTRLVKLHGDVALCSPIKRSGIPTMIMEILCGIGGVRVTHDERPISVSASCGSPSTYVEEEVAMNALWIFEQNVDYSDQEASHRFVMMADLLLRSLNRWPEYLLDSHLLSLLLQRMSDAVRLSLQKGYWNCGCYHDLPWIDSLLSCDDTRLRGLPSQQFWSLLDALEESLAGRYQPQSLISGEQADENFARLKRRVEQSNPRPSCSGEYPGDQAEAAYAESNSASIGLGTGHPFAWGEICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXU5</accession>
    <name>A0A2R6NXU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000692">
        <property type="protein sequence ID" value="PSR79561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXU5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9358" checksum="F93D76B479C46483" modified="2018-06-20" version="1">MDGYNDTFPPTFLEGGLRRPWFMSPRSQLVFVHALFDVTMIVPTTVTVVVGVALRAHTGLRRYTSTQHLVESEFDNDGAGEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXV5</accession>
    <name>A0A2R6NXV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide synthase-like phosphopantetheine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000692">
        <property type="protein sequence ID" value="PSR79571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NXV5"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="581"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1082" mass="117209" checksum="32A26BA03A72CF9D" modified="2018-06-20" version="1">MTVSPLLPPYDGSTTVLPGFLDFHAEHNADLTCFVYPSQDSSSTITNISFREVAEATHRIAHVLRPGRRGPEGDVVAILVHTDAIVYSALMIGIIRAGLVPLPMSPRNSSQAICNMLAKTSCHRIIAQSSLGSLVIDVQSELAQKGFSLQVDDLSTMRAGFQDLINPSHNTNKATIAEPYPTNPSGSKKEDVVFFIHSSGSTGFPKPIPFSQKFLSQWAQSDLILGAGRRGFRWGAMTLPQFHAMGIGFQIIYPIVSGQSVSLFAPQYPAPPVVPHPQNTLEVCKLTCSTALTVVPSFLETWAHSDTAIEYLRTLQAICFGGGPLSPKAGDKLVAAGVKITTAYGGTEFGAPAYTFDEDGAQDSEIKPDADWSWLRFSKKPNLRWVPQGDGTYELQILTSEAFGLAVENLPDTRGYATSDLFVPHPTRKGLWRIVGRKDDVLVLSTGEKIVPLHQEEQITANPMIMGALMFGREREQAGILIEPNPEFAIDPTDEAALAAFRNKIWPSVEEANTPAPAFARIFKEMILVTDPSKPFPRAGKGTVIRNQATALYADAIDKLYDTVAQSSDSEGIPPPTSWSTGDIEHWIVKLAASVNDGRIPSSSQSLFEQGFDSLSATFMRNRILGVLRSAEDPSLQKAVSKISPNIVFEHPSVRELATALAGIVDPTSDTSLAPGKIAADAVALVEKYTANLPLQTGQSRSTDGVVVLLTGSTGNIGSHILAALLADNRISKVYTLNRASSTSEDRLATAFRDRDLPVALLSHPKLHSLAGDLSQDNFGLEQSTYTEIINSATHIVHNAWTVNFNHPLSAFEKQIAGVRKVVDICASSPRPVKLLFTSSVGAAGGWKSDDGLVPEKPLPNPEIAALNGYAASKYVVEQILSKAAENGLNMVSLRMGQACGSRETGAWGTTEWMPILVKSSIALGCLPDIDGLVSWVPLDAIGGLYIDLLLSEQALPQLMNVVHPRPTQWKNVLSAIGEELGGHLPFVPLDAWVHKLEAYASEPTKQDLDNIPAIKLLTFFRGMATTSTSDKVAANVEAGGMPMFETIQLQRSSLTMRQIPSLDDENARVWVRYWRKRGYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYC3</accession>
    <name>A0A2R6NYC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYC3"/>
    <dbReference type="STRING" id="98765.A0A2R6NYC3"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="97"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="214" mass="23628" checksum="BE368B62D1A8BA77" modified="2018-06-20" version="1">MSRLSVPPSSSRAHTEDTPKARSPSPAATIGKGVVLNGRPHDAKSPAPLTPTRNASVAPSQSPAPQSDVEEEEQTDESTTIDMETFNQILELDEDDTRDFSTEMVWAYFSQADTTFGDMDDAFKSKDLLKLSNLGHFLKGSSAALGVTKVQASCEQIQHYGKLWDETAKKELTEVTALEKIEPLLKRVKKEYVDAEAWLKDWYKDQNITGPPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYL6</accession>
    <name>A0A2R6NYL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYL6"/>
    <dbReference type="STRING" id="98765.A0A2R6NYL6"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="148"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="764" mass="86610" checksum="02651026E210E2A9" modified="2018-06-20" version="1">MPVKHLDNYLAERKHLQTHPLSVLSDSRLGIDASFYLTQLTDNPPSREPLLAATGGLPLALTQRIESDLRALEKLRIKPVFVFPGLVPNRRWKQNQHQQYEQNDAMRDRREAWAKYEAGQEDGATRLFEGRSGLQQWDLWKMVLRIFRHRNVEFIVAPYVAWAQLLYLQRHPKAYIHAVFGPTDTLLYPGVEKLITSLDLASNSPSFTHVSKRTVLNDLGLSEDQFLDVGILLGFDHSPPFPPTLHDQALKATVDMVKYYKSGHAAVSAFADQAQVKQIQYPDQYARTRSMIKYSLVLSSDGVVIPLPLSGPNPPSHGHPNHHHHPTAADIPSDLHEIFTHRLPDEIYFYLSRGLMGPQALVWLTTGIINENPPLDNGETTEYRRFVKEVITDGQTGPRATSLALISSVTHSFWSKRNVSGHFWFEQGPQKPTLHNSQQTLQLAERVVSWHVPYAIVEEELRRQNSSTIDFALCLGATVSDKLATRTKVKSGLTPPPLDKKDELVANVIWRFLELRGFLLNSHTHSPLARAMYVAIRTARVNDKFQDSLYLFLELVRAGVMHGHLWSGRAFSGGPSFGTDDEKSCMLLVMRVLSIVPLNFKPQPWSAPLSRELLVFNSFVRSLTRALRTLLEVTSLNMLLRHDARQSRDDLLDINLSLPFQSEVNTGFGVLAKVYLDALTHINNRQRVRDPNAEGVKEAKAMALEICEETFPGVKYPKQEVERGFRFWDVTLTAMRQLHSEGAVLRELIDQFEAAEAWLAPMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ64</accession>
    <name>A0A2R6NZ64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000629">
        <property type="protein sequence ID" value="PSR81034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ64"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ64"/>
    <dbReference type="OrthoDB" id="3251728at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="154"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="323" mass="36583" checksum="801F49DCDD9EE763" modified="2018-06-20" version="1">MAYAYQPYMIPTPYLWPYYQQPSVSPFIPPQQFPPTPNAGTSSRRVHFEDEDVFHTGRARPPSWHAGMMGTAPAPNPAPFPSPPFVYTPLPSVVPLGPPAPGYYNHHRRRSDGALPQPGWISIPTWMVYPQPQTPPPQLNPLLSGEMQQAVLLFDLSQNAYNPLRMTSPQATSGTPLSREELSQTATYPGATRMVITCDEIPQWRVVLEPYEERPSNAGYLGVPTDSRSAAPITVHDVLFAIHKMLQRQISHRDWVDLSSDRATSVARAYTRRCRTFPTTQAFEESQGVRRVDYLLDKYYFKGLMRPRGEQGFENMRLLVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZX7</accession>
    <name>A0A2R6NZX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000606">
        <property type="protein sequence ID" value="PSR81815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZX7"/>
    <dbReference type="STRING" id="98765.A0A2R6NZX7"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR81815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="329" mass="35454" checksum="4B1D1BF9784F9D8A" modified="2018-06-20" version="1">MQSLLRWGIENSNDGGTTQGPQEPHRKLDPEVIDMILGKPDSELMKEALAIAVDEKCEEEERLQALDNFEMLVEHIDNANDLVKMKMWEPLQGLLTSSSSSDEIKRQTLWIIGTALQNNPAAQISYLALSPVEDLVAFLSPSVRSAKTRSKAVYALSGLLKHCAPAVQQFGDADGWNKLKAALEGVHPVSYLALPRSSIVIILDSDIAVRRKSAFLLNSLLIPTTEPVPRPVPNPPAPSGSPSGDTSVTLHPSAPHPTQEPEASGPVHPNSHSSMLSDPSSVSTSGLAARALEEQGLLQALINALVSPVPYGPDGESDEDAEFEEKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0E5</accession>
    <name>A0A2R6P0E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000589">
        <property type="protein sequence ID" value="PSR82344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0E5"/>
    <dbReference type="STRING" id="98765.A0A2R6P0E5"/>
    <dbReference type="OrthoDB" id="2788668at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015352337" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="490" mass="54259" checksum="DC6B9A694761D5B7" modified="2018-06-20" version="1">MKSFFALLLAASAAAVPFSSKTSSHPVCVVGAGPAGLTAAHELQKLGYDTVVFEKGDTVGGKCQAYYDKRGQFHPLGALLFTQETYRETYPLIEESGLPRLPFAYDFKAWQYNWTTGIVAQSPFSFKDIYPHVENDVIQYITFWTDSFAPTMEAIGYPNGIPDELTVPFEQWLKTNGYGGTFRGIIEHAIVPYGYGTISETPTVYMLQYFTPDVLLFFAGQREGFIIDWHEVFVRFANKNVHGPIHTGVSISAIDRSGDAPTVSYTTSDGSKGTQTCDKLVLAFPPLVDNLEAANLELSDSEYSVFGPVRTTEYWGGAVRVATPVGYGYSAETFEPNGRPSAFMRLFANSDVATSWSWGTTGGGLTQQEAKQLLRETISPFNKNPHDTSPPQEITDEHIHGFSATDYFPRYEPAELRAGYFKKFGELQGQQNTYYASGFNGFETVEFAVRAGKDVVKSHFPHVEAEVEEIAVYSLVEQVSGHLAETLNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0U7</accession>
    <name>A0A2R6P0U7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid synthase meander beta sheet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000578">
        <property type="protein sequence ID" value="PSR82692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0U7"/>
    <dbReference type="STRING" id="98765.A0A2R6P0U7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015332279" description="Fatty acid synthase meander beta sheet domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase meander beta sheet" evidence="3">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR82692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="9980" checksum="C9AB0D040EDEE03C" modified="2018-06-20" version="1">MGFLHNPTLAGLCLDWLRALFATPAIAQGAAHIDNPPRRLFAPRKKQHVVIDTEDGQLVSISLVGAAHSYGDHKLTSRPLRPSTMRPLASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1W2</accession>
    <name>A0A2R6P1W2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000552">
        <property type="protein sequence ID" value="PSR83736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1W2"/>
    <dbReference type="STRING" id="98765.A0A2R6P1W2"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR83736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="517" mass="56020" checksum="B2D89A67D89F3F0F" modified="2018-06-20" version="1">MSSQRASEPPSPTTSSTLPRGSACLPCRRRKMRCDGGKPACGQCITKGRQDDCEYTGDLQGLTRTQMLEENISILESRIQELENPTETAPSVRLRSVPAPQAAASGSSETVITLRPPTLPYERVGHAAPGSLQAHMGAGGIPTQPTLQESYIMINSFIPHATQVGFFLNIPRFMHIVYTPADARSPFLDPLVTTVSLWGCRLSQSPALAVHESGLLSRAVQQLSGSLFLAGTENHGNTIIGVIQAEVLLANYFFSLGRFLEGRYHCSAAVSLCISCRLNVLGNEQEARGQGGLAMDLVRSSDLVFTQSEPGDAIHTGEKIGAFWSVYILDKTWAVALGAPSSISDNVRVSTPLPLTMEAYEQAQTIALNRNHRPIEQLLAGQGIDNLAEQSPLALRALASILLARASTLASQYQEDVINRDAYWNEFNVLQTVIARFINHLPRITIVSRGASSEVLVANTIARVASIQLHIRFAQDAMRSRESCLFAANSIIASVQNIGVNELRYLDPIMAVSMAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Y1</accession>
    <name>A0A2R6P1Y1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000551">
        <property type="protein sequence ID" value="PSR83807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Y1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="9828" checksum="2FB1E2A81DF5C715" modified="2018-06-20" version="1">MDEDELPALGTLPVVSTIDFDRSLVCFWRNFGNFELWDVDGGDEGDWECLAEEDIVNVVVAVVKVVEEVKVADMPSSSRPEGHLCTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBW1</accession>
    <name>A0A2R6PBW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000512">
        <property type="protein sequence ID" value="PSR88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBW1"/>
    <dbReference type="STRING" id="98765.A0A2R6PBW1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="415" mass="45333" checksum="80AE197E9C4DDFAC" modified="2018-06-20" version="1">MANGKTPQNFPATKGEFEYLTKERYEFMHGVPIKGDTGHQCHLYGQWLIPRHSLQAGGQGPLSAWLNTTAFISSLIKLPRIPLSGLPLHAAMASLAETPLCKSTSRRSGTRNLTGTSRSVDDQDFNRPLRERLPKGSFDLDGKLTNEGYDTLSRMIAFGKHRRNVADALELTIDDLPKVATILCEKGCGKTYVLKDQLKEHMKTCGVPDQASGENVSINVAELMDQLSARLPIPEAFTPDGKLTSGGYTAINGIVIKSRRDAIKLHVKKCGVPGVKTSKKRKILEDANSQQNDTKDEYASGGFLSSQFTDSTSDSSDSRLYLGAVPSTPRRGHTVANDQYGILPSPFAYSLYLKHEQDAADLGPFLVGSPARDAAMGLFSPHFGVAFAYSPWKKPRAVYEDSLRVGSPDAFGRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC62</accession>
    <name>A0A2R6PC62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC62"/>
    <dbReference type="STRING" id="98765.A0A2R6PC62"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR88841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="32473" checksum="4AFF2913811CE978" modified="2018-06-20" version="1">MAGNTHSFTGYGWIACLWILVVSFQYGYHISALNQIQAVLTCRGTDTTDTDIPIQHGLPTCIPMSDATFSVVTAVYTVGGLLGSLFANVIMDRWGRKGAVRASSAMFVLGSGIMGISASLTALIIGRILVGIGAGFGLCVGPIFLSEIAPTKIQGAVGVLTQFAIVVGIMMTQAMGLQLATPHQWRIVLLFSAALSLAQLLLSPFIVESPTWLHRRGLLQDKAAAARRLWSIGDSPSVDFPTESSSDPLLGPEEVDVEIQRAKDPEDHQASVSLPQLLTAPELRKPLVIVCFSMLCQQLSGTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMS5</accession>
    <name>A0A2R6PMS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMS5"/>
    <dbReference type="STRING" id="98765.A0A2R6PMS5"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="4">
        <location>
            <begin position="57"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="3">
        <location>
            <begin position="400"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="3">
        <location>
            <begin position="464"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR93718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="650" mass="74048" checksum="BE07501FE12C4C39" modified="2018-06-20" version="1">MPPRRRPQFTQENIDQQLQQIHLLDPSSTSENLEQLGPIIKQIHTNRQQDAYLRTVKGLIESKDAEIETICGDNYQEFISSVSTLFSIKSYTTNLRDTITLLDQSVAQVGRGLVEKKKALLQSKKTAANLDEAIDTLQACLRVLDVVHRVGEMINEGKYWSALRSLEDIESMPPTSLSQTPLFQHLLSSLPSLRGQIKDAVNASKKQWLLDIRNVSALVGQLALEAMDARTRKWRARRDKDPVLKLSRVGSAVETMTYEKTEHNVLDNERLKVDFTPLYQCIHIYSALDALDEIRKSYQADRKAQSDLIIPETLPLGSLSSVTQEIVGFFIIETHVLSTTGNFRSERDVEELWDALVSRLSGVVDRMLQSETDADSFLRVKEGLIGFVMTLETYTYSTTSLHSFILLLFERYVSLLENQFGKRFQDIISQDDCLPMYVEKTSEYTGVLDTVLLSKDEREQLDQSSQRGGQIRVNAAQSFQATLTRALSRVNASITSKLDDFFGLSEYDWTPTTRESAPSMYLYELVNWLTTVVDSLVIKQEYKDEAYRNAVEYLEDCLMDFLTGRNIPMMNENAISNILVDVDFLEEEFKRIGRSQLMAAFTELRSRNLRVLDPNVEINHRGKEGRDAGKKPRLSEGYFLARTVDDVDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNB6</accession>
    <name>A0A2R6PNB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNB6"/>
    <dbReference type="STRING" id="98765.A0A2R6PNB6"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF7">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="22662" checksum="873705B8AF14F778" modified="2018-06-20" version="1">MKVADQSWKAGTADSNDTLVGCSFSASGACFTDRKLAGVRAYHEWMPIRQVDVDDKLRIWRNFQIGKLLDAWDGYRANRNRILDHLYNNEISNTVILSGDSHANWVSDLALTSTSSFGSGILPLQANAKSQTYLTDKLNADLQWSEGSFRGFFTLTIEPHQVNATYWAMQNISANKLSRPVAGGKVAAGVLKTEALAAIDTTTASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNS0</accession>
    <name>A0A2R6PNS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase RNF220 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNS0"/>
    <dbReference type="STRING" id="98765.A0A2R6PNS0"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase RNF220 middle" evidence="2">
        <location>
            <begin position="51"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR93784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="469" mass="50996" checksum="BF651182E6761E8E" modified="2018-06-20" version="1">MSSLTLDNYVRGKNRVVYSDPEESDAASTSDTPIPSAQFAPFGKARRAVTKKCPVCDEEIPVRLLERHADLEAERLDEIMRSIGSMEVLEMAEPDDGLTARTRRSAVQARKNMQPKSFATGGPSSSDTATLELVDKSLRLIKRRRKQRHAKLRDMTREDEDSGGLSGFRGGRGRWTGSSEGTLCPVCMKIVPGDPDVVEAHVDACLAHGARMQGERDREQRERQRDESPWEEVDVESEVQLRATDGVSFRGMGFAVRDDTQRDVDDDVDVDGEDEAVYGAAQFSEGDVLNPISNGQPGKEDSTGIGENGDDPSQSPGASGSGLTTVAIETIQAVTINVVGLGPESHFDVNRTMDDVMGVAELEELDRAVQRARRIGDTAALVLALENKMKILTPIPSPQYPLAAGIPVVGNVGYGAWVQPAYVQSASVSPQLLIYEEYIYDLKSAISRNMSNLSPSAAHMLCSSYLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVC0</accession>
    <name>A0A2R6PVC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000441">
        <property type="protein sequence ID" value="PSR97281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVC0"/>
    <dbReference type="STRING" id="98765.A0A2R6PVC0"/>
    <dbReference type="OrthoDB" id="2635432at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR97281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="796" mass="91385" checksum="D27D8B7E7E49E7D8" modified="2018-06-20" version="1">MPKPASHRGCVLRESTPAIAEHTHTRSFQYGRLPQQREALLLDAEKVARLVPLDYFFDSVLRPVAPKLVDRVLHKLQSSDKPVIVDHRWVDFPVDPSRSPESEADTFLPLVNIVKEITSASKRKGKQPILHYKSNPHAIPESTYRDNSSRPDGYLIRRSHSSRWTNITAIGEFKKKKSRECIRDNYCKIVWSLHHCMSDDSRRRFVFGFTIEDTIMRLWFCARGVLLITEEFNFIEDHDPVVRFFLSMLYAKEQQLGWDTTMIPVGRFELDIKVRAASGEQHTYRTDRRVSDYGADSLLGGGTRIWVARRVVNGRPYGEPVTVKDIWVDGNRCREGDILDAIRDAQPSEAARQSFKTFFLQVECHGDVFIANDEDQMVSDNTLELIMRGQDIPDDAPLFDLLRSPLLEPAKPHSISHIRTSTGHHLTLDKDENSLRKILKPNAKSHYRIVSTGHTNHDYMSFHHWEVFFRPQAIFSLVGTIHQVDLTFDAVADFMAVEVTEQAYQCHFTDTMALPAPAEDDPDADYNLALNVQNHCDVQVGKKHQLVLQIESGLAHLFRENPLHDLESLWWIVNYFLFERKLLAWQDNGDSEVRRALQQSISARELFSTRTKAFFRDTFKEHLVYLHPSVKVAGEVMENWRSLLVGAYLQVEQDPASITHTAADGLHGIFLRNAFETARDLSKRNVVIHAAVIQETEDETDKDEVEMQEENELLDDDGNDEKKDEVRQPGEDCFRILANKKRGRPLESIYEGVPLDTTSPPLMKRLRPLVDKCQALNGEKPGLGVRFRTTARRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PWC6</accession>
    <name>A0A2R6PWC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000436">
        <property type="protein sequence ID" value="PSR97469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PWC6"/>
    <dbReference type="OrthoDB" id="2802955at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="59157" checksum="D8B40F91D679B233" modified="2018-06-20" version="1">MVSFSLTPTPLRTVTGANIPEDLFERILDFLDKEIDSAISFNEGWKKKEKHELGRCSLTCRYWATRCQPRIFEHIRLRSKKHLDQLLSMLESPLSCISGYIKHLYLNQNTSNSEPWIHLVPLRLVPKLSLSPTISLLFKGGWENSHTKRFGHLRSIHYMLPSAHPELSSYISHLKLYKLQFRRFEDLAHLVGELRSLQRLECWRVKWSSPVPEIYVIPVCPPSLARVKMRSCTEGAAGVLFLMGKRRRRQRNEAIIPFRLDRNQQSLATPSVRSWARALSAGDKWSEYTIEKVNDVYHIGCKCHHSDINFIFTPTTEPQKSEVHLETVTISYDSWWIIYKATKDYLKRSDTLASRLPDLQKVVLGFRSQDDMLHFVNEVVNMQMENLRAAGKLRYAIFDKSETKRWMRVPPGSNQLEHFKVDTRLPGLRILFKHRAVRTPWHWLQFSVPLVAGLALLPDLDFRRILPAPPLELFRAVWTFLIQWAVNECHHFFGPQWASLNIDETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q293</accession>
    <name>A0A2R6Q293_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000405">
        <property type="protein sequence ID" value="PSS00865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q293"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS00865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7739" checksum="B7EBC3BA5824C197" modified="2018-06-20" version="1">MNAPRPFKDGCPSQEIRELTRLNADESWAVIVGTIDLSFNLLARAVMSGMPIYMTDLPLRSYVFDYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2A5</accession>
    <name>A0A2R6Q2A5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000405">
        <property type="protein sequence ID" value="PSS00876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2A5"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS00876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="11402" checksum="CCCACE4A1341BB5F" modified="2018-06-20" version="1">MTVMEGKGLPQAYERLEKILNFALVPHHMRVVVVGTVSLFWSTYILPFHYIYRDTQTITILDTYLSMVNAESEKERLMEATRDDQPLQAVALGSEKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5C9</accession>
    <name>A0A2R6Q5C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000399">
        <property type="protein sequence ID" value="PSS02211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5C9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14684" checksum="04D8F5210DD20EF0" modified="2018-06-20" version="1">MQHFWGNKAEWTSNQETSLFWKGFNQASENKTQTDLYSLFKGHSSTARGHASLATSVAGPSRSLPTPKQEPAPEQSEQDLEPKREPKNEPSDPSDPPPNPVSSEAFQALIKKEFEKPDKKTKAMLRLTQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBK6</accession>
    <name>A0A2R6QBK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBK6"/>
    <dbReference type="STRING" id="98765.A0A2R6QBK6"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="396"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="959"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1270" mass="137201" checksum="23D8E82309E69988" modified="2018-06-20" version="1">METFLRNQAFARQQQSQQQPNLAMHAQMNGGPSLHDQALSNQQQQQMGNPTLNRFLSARNLQTMQNPPAEAVNRQLQLMGLAQHQQNQHQLPNGQNLVALRQQQQQQQQQQQQHQARMAGQMNQLQGGIAHNNFLPQANMSTASDGQQQQSASAAQTLMNQRAGMMQHPAEIAQGQASMPNRAMSQTQLRDRAAMLTTSIKELEKRTMIVQANRAAKSEADFFKELTQIQNEITNRKTVLIKIAQAMQTIGMSTASGVNGHNNGPAGQGAQPVNAMPGGQPTPNWHPQAGPSPSNAFNNTQLPPNSMQLLPGTPHQQNMQVNNSQGNRILQQQLSNRSVPTPSQQFNSPAQNLSQGSPGMGNAPQLGVHDPQTSNGMSVAQTAAQMQMNRMSALPALPAPTFRAAYQTWCQKQGITPDDRMMNFEGKPIDLHSLHSEVLATGSTGARLSAEQWSIIGGRLGFIQFPGTGPDNPPQSGPGVAQHLQHMYKEYLAQFDAAYLRSVINKKYTAELAQGASTSTGPLQVNASNNAAGHNAPSMPTNIQQQYNNQASNIGMAAPGLAALTGVDPQEANQLLALSKYPADELRRRGVPSHIVDKVELHRALLQRTLQGQTSFRDGLKNSQVPGNSSLIEALHHQQQQQQQQQQQQQQQQQQQQRQLMSAASMNHGPQPGFSMSNPGMSGPMNMRPPGGENPARANPTMSLQQHTPFAPVGRQGEGSPSYRPSPQDQQKALQLVLGIREEYKSYVNNRRADIPEQSRMEYSRTCDQLSRLATEVDTKLHFMACFMKEDGIRRLLQVIHNARQQMSLLSSQVPKYIMTMEDVKGSLQMLRYACDMVKKVLVNGTLENGPLQQHPVPPALPAAGLMSPPRPNIPVQSAPPPQSQPLQQHPVPSQQQLSVPGPSGQSAAFGPSSSHSNVHTPQSMQPSPRPLPAQTTPNPAAAPLKRKPPLSAVPDAISSSTPPASASTPAASAPTPTHLTSSPQTPKSPKTKAPPKPKPPVKRKASVKGPPPLPSTPTPAATSTLTPTPTSESSTLPPPQESSNKRRREETATPAPTPSDHPSPKKPRTDWDGPVSEELLKKKQDVESISTDDDATQFFERMTDLMKLATGDGQEFSPEISDTLEQILKGIGSVPGDDTALGFLGDSGVMRPPSPANGTQTGLDDFFDFSSYGAVDDDVGSKAATPDLVPSSSANPSPGSETDLGRNSLGPADTVNIAEQRSEDGLDDVLGSGVWREIDGGQAAYHNNTAEWKWDSPMPALEQPWAFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBP6</accession>
    <name>A0A2R6QBP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000367">
        <property type="protein sequence ID" value="PSS05550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBP6"/>
    <dbReference type="STRING" id="98765.A0A2R6QBP6"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TEA" evidence="4">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="2">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS05550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="481" mass="52600" checksum="4B20866BCDEE8DF9" modified="2018-06-20" version="1">MSSSRSFAQHVSISSLDDLTYTVPSASSSGTNDAIQTIVTGRKCWKTIKGKGEVVWPPYLEAALVEGLEKYRPVETRSARALGRFPMRNKFISDYILQTTGKHRTPKQVGSRLQQLRDTCEGKRILKLLSRRPSDPPRADDAPQSPEPSTSSIAPRDYVSIDVLPADAPWPSSSGSTSSFTSSLCSIPRPLYAIDPTVTFQSRSPITAYSFFRVLKNGAAVHEETSEMQMRSSSCRPSTSWTSEVECNFLYSTALVPRYWKFLCECKDVSSYIIEQDIVRSAHADRTDTRSLSPTNPEDIMFSVTYRFNSNHSSAPQSPISSNGDTYSVESSPELGPEFDTVPMLNPYNDASASMVSRPYPQSSQRQYQQYHQQPSHRRDAFELPPGLIHAGEDGYASLPQSPLDMTFGGINASLGSSAGADPADSICRSYVDMDYSGACFDANVGVNVGPIGPGVVPGYNVAMSMAPYVSGFSCPERPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEH8</accession>
    <name>A0A2R6QEH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRAPP trafficking subunit Trs65-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000361">
        <property type="protein sequence ID" value="PSS06537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEH8"/>
    <dbReference type="STRING" id="98765.A0A2R6QEH8"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="970" mass="105426" checksum="827DF9424BF49403" modified="2018-06-20" version="1">MTTFEELFNKSVLAVIAPEASLGFPSQNDDFISWQDWLSRLEVESTDRKLAFFDENLNFLLTLRFEHSPSESEPDPKKPPVQLLSFLAHLQISYDASYISSIARQPTSPLPPEINRPPIPPRHQSMPNRNRPSPLAPPHPSIFPPHTPNPIPSTTENDRQYVQAQGTPLRSGVWGEATAISAPSASEEFALLWSESDRSWVAIFKMTVQVSFMPTRVPNPLLCLTASATLREKPVTTTPIRQALTALIEAAGGIPSSLDPSSPMKASGDEDDEDASDITGMEEINLLEGLTLGPTFAFAKSPLVLSSTRLGTSMRQQAFALPSTSPPSSSPLRSAMTPSTSRPGASHPTLRKSFRKTLRTVSGFRVRMRTVFVPYFMLPQTSSQKQNKRNGRQCKAQDAAMKDDSDADDDLELIRDRELLEAGNEEHTVVLCVEVENSGESSAGFAVESVNVTVGGEGAKTQLIGWGDFDLSAPDKVFPLLIGPEEQYNLLYAVAFMRTPETDEFSLARGRGLPGAPPVQQLQRAVTIILNGRPYEQLLIEEPPVKGKKKQDLHLLYPTHAFPSRWNCVLDLSSQAPSQNINTPGFGGPLVSLNEALPTPASPFPSATSRPTLSRPQSAFVTPTLGLRPNTPGSGASTPVSVVAGNKRFTFSAIDTNLQIGGDSSRLRPPPSPMNYRSDTSLLNPANQQDSLAQSGFPQSKPSTPSGGLSANPIAQNRASYIPPSLTVPTLNRTPTTTYGPLSPPLPSLPRSQSFAFMQEEHMSSPVSYEAIPPTPAYPAFPTSPLPPTPHWQGPMSNLQSGAVGPSIEIRREKGPNAMGIPPTPGPRVGAGTGFMQMQMQGEAALRGGSTDGPREPIVVSVGLLQRADGDEVHAGALGRIYPLDRFTLDIFVFNQSSWTRRFEVSYPDRRRQRRDQMHRAFDTEGTIEKSLADSPGIIPLENRVRVGSVIDVVVHEQELIPEKVAAEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEK8</accession>
    <name>A0A2R6QEK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEK8"/>
    <dbReference type="OrthoDB" id="3206554at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6604" checksum="215A54B35F32B28B" modified="2018-06-20" version="1">MSDSPSIRPSMGALVLGGFVSVLGLDFMHTIMACIANWVNLIEHFGDTSQADHISCADIPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEL9</accession>
    <name>A0A2R6QEL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEL9"/>
    <dbReference type="STRING" id="98765.A0A2R6QEL9"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="570"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS06569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="667" mass="69243" checksum="6832395F47B8F71C" modified="2018-06-20" version="1">MHADRLVKRRRSRRHQPLEEREPALITLPVPLPPSIPIIGPILTPILDPILTPILNPILTPLIAGNPVTTVASAPPAPTSPVHTLVPSTPATQPQPQPQPQPQPQPQPAPTTAPSTPPSSQPGGGSSEQPPLSNNGSGSGGGDGNNDNNQGGTDSGNGQGGSNPGSGNAGGSQPSEVSSAGGHSEVPPDSPSQATPGSGGSNTATTSLNPVIGDATGNGGNTFLAGAIPTSTYKPAVNFGDDPGTSTLGESVPSVTFSAIGSLGTGNSGGDTHQAGSGSNSPGSSGNGPDDGGSTNGSGPGPQDATHHGLSKAVIAVIAVIGALMLLALLVCAFRRCAAAKRIAYRRRWFRGSIYGVPPVSSSGYFRQHPASARSSFATNFEHDPFVAPSPPPIPTPLPLSSDWPLYQPAEMAQTNPAIITLPPAAPTTASTPSPPIRLFRRDSYDSVTTGHTLTTEGIPSNLSLPQIITLSEHHVVSSEHLGLIPATPLSVRPFSPSERWSFPKPPNGARPDSELYPMMYSVSPDSLSSSEYITAPESEDPFSDFAVAESVDAHTVETFITVDTDAASHFSPVEIVCRPFVPSRDDEVAMNPGDEIRVLKRFDDGWAYAENCVTRKHGLFPIDCLRMANQDLPAFLAAKRISHYAAVTPQSRAVPRMTTVEEDHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIU6</accession>
    <name>A0A2R6QIU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000328">
        <property type="protein sequence ID" value="PSS08930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIU6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS08930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7297" checksum="520385F5C20A60FE" modified="2018-06-20" version="1">MAAMRPLDKKVKSEAKNTAARTGMQHKKCFDIVTDNGLETKAGNERKMKTPGGWGEKTSEELATWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0X5</accession>
    <name>A0A2R6R0X5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000286">
        <property type="protein sequence ID" value="PSS18891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0X5"/>
    <dbReference type="STRING" id="98765.A0A2R6R0X5"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS18891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="21082" checksum="9D9CB2795C98366E" modified="2018-06-20" version="1">MKGCDAKGLYPLYVKSFRSRKGEEVRQLAPCLFILEDLDSLINDNNCSFVLNQLDRIESNKGLLVIGTTNHLDHIDPAFSNCPSRFDRKCVSTLVLMAGFEEGNEMRDFADVIKRQIKALRKQLSAEFAGHTPNTTQRGVVSPFDRSGRPDSRLANEGRIWGAGETFDRLRGPADYPCLACRGGIRTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0Y9</accession>
    <name>A0A2R6R0Y9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000287">
        <property type="protein sequence ID" value="PSS18888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0Y9"/>
    <dbReference type="OrthoDB" id="10016792at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="224" mass="24421" checksum="87C59D360F30CF2F" modified="2018-06-20" version="1">MEISGSGSADVPLSVTSDVLMTIRSNLQDLLLTATEDNSGIPATFPADWASGTGKRRWLSATELQTFLTEKIVMLPITPVFPKQKSSSLSSDFDSSANVRVYRVRFYLQGLKATSDCPSMPKMKSIIAHSGREVIVSRRGVSNLFDHSPLNTLHSYELDGNGRVVNVVDNGDLVEFVPGSAFGAPGPFTMWAVDSSSAEWEMLDTSEVVGAYLEFFGTNYAFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R103</accession>
    <name>A0A2R6R103_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R103"/>
    <dbReference type="STRING" id="98765.A0A2R6R103"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS18926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="165" mass="17494" checksum="8E1E1C248E0E1768" modified="2018-06-20" version="1">MAPKIDPNEIKIIYLRATGGEVGASSALAPKIGPLGLSPKKVGEDIAKATGAWKGLRVTVQLTIQNRQAKVDVVPSASSLVIKALKEPPRDRKKEKNIKHTGNITLDEIFDIARTMRSKSLAKTLANGAKEILGTAQSVGCTVDGQPPHDIIDAISAGEIEVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHV7</accession>
    <name>A0A2R6RHV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v2764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHV7"/>
    <dbReference type="STRING" id="98765.A0A2R6RHV7"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS29616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="657" mass="75418" checksum="F32995A31199C45D" modified="2018-06-20" version="1">MLEFCKISFAGMQLLRKKLPQRTDKNVVKGSACTVVPKLLAGISYLRVVFNFWEPLHYLDRGHGFQTWETSPTYAIRSWAYILLHLLPAKLTKFFLGPEKRPAFFAIRVVLAFISATCEAFLYRTVVDKVNYRAGRYLMFFLLFSAGMWNASISFLPSSFAMYTTAVAFAHSLEAPSKTNMRRTLFTTLLFATGAIVGWPFALAIAIPFVFEELFLFGADTVPPKERASWMISRWGRLITCGLVAALLFIPVVAVDTLFYGKLTVVPWNIIKYNVFPDSQRGPELYGTEPADFYIANLLLNLNVIVPFAFASLPALLVTHRFDRKRLGDRAGPERSSPYTILLVRLAPMYLWFTIMSAQAHKEERFMYPVYPLICFNAAITLYLVRGWMEVVYIKWTKSPYRASQAVLFSRFTLSVVSASIVLSVSRGVAQWKYYHSPMSVVAHFEAYELVRLLNTTGHVYIPPPKYHRRRRIPTSEEEEPRINYDLLYPFNLTLCLGKDWHRFPGNYLVPDSVKVEWIKSEFDGMLPGHFAPTPREAGLVGRIEGTHVIPQGLNDLNKEEPSFYVDVSTCDYLMDSFFPLHSETSRYEPAYAADTDHWDRVKCLPFLDARHSSLLTRALWMPGQRWQRLNNFGEICLLKHNENIGRKEKELAVHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI08</accession>
    <name>A0A2R6RI08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI08"/>
    <dbReference type="STRING" id="98765.A0A2R6RI08"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="428" mass="47004" checksum="C33CC0630DF201C9" modified="2018-06-20" version="1">MVTTRGQEAAGKATVSPNKTGPKKGQAKKKEEPETNAKRDIEEVADHIEGAEGEPEVKKAKVEDKGNKENEDAKPETKGHPAEHSYQAGKGIHNLMPRSRPMIVYSTGTIERGHIYFFYRPRVQLEEVHSMDDVQRFHILLVPRPPEFSVGSDQKDAQPDEEGEMKLISSGSDVIPAPESINEKKKPFRLLAIGKKQLPDPEASGGGRKGVFWALVSTVGEDLQKLQDGLGEKEYETKTRGTRHQGPARLAARGAYAIVNNEAKTPSQRETHLGYHLSHPIPENFGDVQEALGIHPASSFILQVKNPLAPNTGSARVGLPSNRRAEFPAYIMKQVFGQGGARGREDFGLKFASVERKEMLDHEGAELLLIAARSGEEGLDKSLQGEGRGQALKDTEETEGHKSIETVLKELAMDSQKIPAEPLEGNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIA5</accession>
    <name>A0A2R6RIA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v2897</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIA5"/>
    <dbReference type="STRING" id="98765.A0A2R6RIA5"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="47"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS29749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="315" mass="33901" checksum="0A14A263A54E205D" modified="2018-06-20" version="1">MVDARPIAPEILTNLFSLQKHKSSLSIFAGDDSVNIPTPASPESSRPYVTLTFAQSLDGKIAGKDGLQLALSGKESLVMTHWMRTMHDAIMVGIGTALNDDPQLNTRHLPQLSAGSAYRYHLPRPVILDSSLRFSPSSKLLKNFKEDKGRRPWVVCSPPQNESDLVVWNERRQALESAGAKIVEVHGSQGSRFVTSVVTIITSKIFDSPGHVSIPALLSSLRELGIRSLMVEGGARVIRSFLAEAQSSIGNDKSRSVDAVIVTTAPLFVGADGVGYESGLSSSEVSLDASSPHVFNLIFGPETCRKGLKVTALPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLM3</accession>
    <name>A0A2R6RLM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 17">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v2549</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 18">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 17"/>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLM3"/>
    <dbReference type="STRING" id="98765.A0A2R6RLM3"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSS30924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="402" mass="42913" checksum="65E6F44689A159AC" modified="2018-06-20" version="1">MSLSKKLAITDLDLSGKRVLIRVDFNVPMQDGKITNPAVCAKTVILMSHLGRPDGKVVAKYSLEPVAKELETHLGKPVTFVKECVGPEVEQTVNGATPGSVILLENLRFHIEEEGSAKDKEGKKTKAEPAKVTEFREGLTKLGDVYVNDAFGTAHRAHSSMVGVKLPQRAAGFLMKKELEYFAKALEHPERPFLAILGGSKVSDKIQLIENMLDKVNSLIICGGMAFTFKKVLENVSIGNSLFDEAGAQKVAALVEKAKQNNIKVVFPVDSVIADKFDKDAKTAVATDAEGIPDGWMGLDAGPKSRELFRQTVLEAKTILWNGPPGVFEFPAFAEGSASLLNATIEAAQNGATVIIGGGDTATVVAKHNAEDKLSHVSTGGGASLELLEGKTLPGVAELSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLU7</accession>
    <name>A0A2R6RLU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000224">
        <property type="protein sequence ID" value="PSS31007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLU7"/>
    <dbReference type="STRING" id="98765.A0A2R6RLU7"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS31007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="11574" checksum="7356EAC40F3857BD" modified="2018-06-20" version="1">MPVTPVTSFDEFKTIINSGDFAVFDFWATWCGPCKVISPIFERLSNQFTSVKFYKVDVDAAEEISQEVGVRAMPTFVLFKDGQKIKDLVGANPAGLQELIQHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLW9</accession>
    <name>A0A2R6RLW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase-associated protein LEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000222">
        <property type="protein sequence ID" value="PSS31027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLW9"/>
    <dbReference type="STRING" id="98765.A0A2R6RLW9"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58453" checksum="9A547119B89DE95C" modified="2018-06-20" version="1">MSSLAGALDETLATVPKAEDVVHDLSLAAQLEDDVEMDVKPRSENGQDADDSAPAQDEDMEDLFGEDDVADDVKHEDALTPASSEHADGISSPERRHREAMEYPEDDEPETNSEVVQLEATAEIPNIPVPRSSDGNHWVIRIPNFIKVDSKPFHPDTYIGPEQEDEDIHPGESLREKSMSIKLKVENTVRWRWSRDGSVQDRRQSNSRVIRWSDGSLSLKLGKELFDITQSIDNSAAVPRQAIGGPSQSSQGTLSGAKPQGLTYLVAQHKRAEILQCETTITGYMSLRPTGMQSDTHRMLVRAVGQKHSKVARLRMAPDPTTDPEREKLELMKLASKKPRKARGEDDGLGGGRRKRTGYSRKRSGDDMWSDDEDEEIFGGGSEDEYGHAGAPGRNAKRRKAGEEDNKKRGPGEYQNDDFVVADSDEDGDFADSDEGEGRKKKTRTKRHEEPEEDDLDKLDAKIEAEQRKRRQQEATEQTGGDAKITGVEAMEVESEEDEGEWGVRRAGTGPRKRRALGLDEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM61</accession>
    <name>A0A2R6RM61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM61"/>
    <dbReference type="STRING" id="98765.A0A2R6RM61"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="72"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS31065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="468" mass="52462" checksum="D7BDF8AA5896C6F4" modified="2018-06-20" version="1">MKALWRLTKGKPNMISLGNGDPHYSLYPVKKIQYEVASAAEDIEDPVAVWTAAGPSTPTQLFTSSRDEPCNLSLKTALAYSAGAGLPEAQRAVTELTKFYHSPPDHISTLTVGNMDGVSKCFRLLGSPGDHFLADEFSFNALTNAPLSHGVNWVPVKIDKGGLIPSDLERIMSNWNEETQGRRPHVLYSVPSGQNPTGCTLNADRRKKVYELAQRFDLIIIEDDPYYYLQYSEEESSGTPSKLMPSFLSMDIDGRVLRVDSFSKIMMPGMRLGWITSSPLFHEHLVSLTDSSTQHPHGFGQIFITEMLSASGWQISGFDRWTRSLRKEYQRRRDLFLDIFAREVSSAGFASADPPQAGMFVWIDVHVRKHPRYRCDIRDSEGSIARTNVPELMEELFERCLDSGLVVMPASIFVAPTSPQVSKILDPEDPIQDRVNFLRTTFAGDESSMQPGLKILGEVLKEFFQEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPS3</accession>
    <name>A0A2R6RPS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPS3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="317" mass="35292" checksum="BD365ED6A8FE8C4D" modified="2018-06-20" version="1">MERFLACISFPQNVQISLVASGTNKHNALMTAVEIMRYASDSDLCSASRHTHVRLAVVSRRTKPSTRVFTLHAGLNHHETKIRFQITYSNSSPSHSHEQPLSFIETIPLAMRSITTLILDAAEPSPTSTAATTTTTPNAIDRDYVGERWCEVLHALANLAELQITHHVLPYGALFQRLGGKAPDDGRRIWLSSLRTLHFKDLVLRGERCACGCTDAEGKRGAYGTCNAVDVKQFYARHSEPDWADFDSSEYADNAALWIEGLRRGLERRNANAAPPLSLRFSASSPREWRRSCCHHADIARVIRPLVDTLEFLAPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPU9</accession>
    <name>A0A2R6RPU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000202">
        <property type="protein sequence ID" value="PSS32047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPU9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="110" mass="12223" checksum="B05C9EAD8DC07012" modified="2018-06-20" version="1">MVVGLLPEKAPASACTNAKSGFDESQVRTKPNRRKPDNDPVSGPSPIMKLIGNENAGRTDPMFYVNADNFIKTCCEPTTVDFDHHVFMVTPLQKISNWPDPKYQESLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPY2</accession>
    <name>A0A2R6RPY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000199">
        <property type="protein sequence ID" value="PSS32083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPY2"/>
    <dbReference type="STRING" id="98765.A0A2R6RPY2"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1159" mass="128705" checksum="C0B399BA337EAB2C" modified="2018-06-20" version="1">MCLGENNAPQCSHYLNAQLNALYENSVGCVQRHGNGLQPDQGHRYSFALAEYYHGKHRRGQASKADMMFYAAFDKPRLDFICNHDAILRLTIKEGHYNTEFTKGAINPANADKNKTFSNVEVAFRVPFSVTGIRGQDLKLGDGDNVINLLVLEFTKAHLVSVTPELEAGRSALSYYLLEYLQLLQNSGNHVLFSLPDFDDDRRRVTIDFSANSQALLDIDEIYGVSVEKINTFLSSSWLKAAMLAGGKNGPSTDRAALSLAEYRSTWVLGDNSTYFHVKLGAPRIKALCNQEVVLYFVIDEALFYDSQDFTVAPKQTYQNCEIAVLVNVIHEQEEEGNVTRCKLDLNSGCLFLMSLDPVANGSIACRFMRQFCNYSAFDQTNEEAVRYLTRLVDFFTSDYLDVLESAQYHVCYHYDARWPQLSGLEDAERIEEAEEESDSEDEAETEAEIAAAAAAAAVAVAAGETGVETAAGAGAVEGGKAVASRAGRATRQASGQITRTIDGRVVTSQGVATTYVSKAAAWKEITEKTDMQGFDHVSAVSQAAINAYFKSLWTAAQSSKNAVDATLARYTYEQYFSSSFQPMNVRLLSNGRAIVWVHLQEGWLKTLRNWLPWSESAQYKFENWRLAFEVELKIVDHDKLDGVSAAWNAKFQDSFVFKHHGKSSDRVLKHIYLDFKNAEFIHEFSNFDGLFNSHDKRPIDKVQALVTYLQSYYFSSLVSSGLHVLYTLPVWKSGVSLPANALTDVTFQIYSKSVFDRRSWGRMTKDTEPVMLILGVTGFRALPAGQLKYSCSWVVRATKSISYGTVCISRKVFLDDRLLTLLARVNAITTIVSLPFALERGAWKLQLTTWSQSENRKDSNCRWVLDGDCSGILKYKWEHRDGWRYEHEGTADITNGSYSVDCNTKNYLEIPTVFKNGTLEIKIRGEVTLKIGVKGTAQNWSARSAAKWHTSLVLHSEADGLKISIVNPPTPVYEKAHIEGEVVSAFFTSPESLLKANLPTTVDLGEVLGLFKSFEGIWNGIYPGTSAYTLAQPVFNKNGDILFELRPHSQICASAPPVVKASSTHHTSRTTTTRTTSTIRPSMFSRPSLLQRVKNSLAGEKEKNHPQSNGKVNGEGHCPPPPPAQAEGPAPTPAKPDPKAKKVKAEAKPVENGEAPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVE3</accession>
    <name>A0A2R6RVE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000172">
        <property type="protein sequence ID" value="PSS33983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVE3"/>
    <dbReference type="STRING" id="98765.A0A2R6RVE3"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS33983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="394" mass="44564" checksum="BB649B99D7FB7126" modified="2018-06-20" version="1">MRYDCQQCARSFSTQGGLKKHKNASHKQAQFVRPSPPDNNFPPDNEHPSRDGSPEDAEECGGDGAVPLTVEVSEYHSIMNAVRCDQDGNPVQDGTPPAPSNAQTNDWKPFSNRVAFELGEFLYKEEQMSQRKIDKLLELWAASLLEYDGTPPFASQQHMYDTIDAIAVGDVPWATFSVKYSGEVPDGDIPTWMLSEYEIHFRDPHLLARQHLSNPGFKDGFDPIPRRDFDSKGDRVYNDFMSGHWSWKQADILAQDPKNCGAMIMPLIFGSDKTTVSVATGQNDYYPLYMSSGVITNAYRRAHCNSVFPIAFLATPKSGRKYDKDPVFQKFRWQLFHKSLAFIMRSLKPGMTTKQLVRCPDGHYRYMLYCLGPYIADYPEQALLTGIVSGWCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZS8</accession>
    <name>A0A2R6RZS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000120">
        <property type="protein sequence ID" value="PSS35533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZS8"/>
    <dbReference type="OrthoDB" id="3024736at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="272" mass="31131" checksum="686D6B08E8D9E82E" modified="2018-06-20" version="1">MAEFLGSIHTPYLHHLAVDETLSQWTEIAVITLLEDISRHVHLQELRICLRRIVTTSFTSIETLFGLTRLRSLSLQGIDFLLENDTIQQFGRAWPTLETFRLDWAPYQGDPSLFTLDALELFAIHLPHLNKITVYLDATHLPPSPSSNYRDVSTIRPDIGVDFSLGVSRSPVKESIATQIAEYIARIYPHANIQSLDFNSSEESKRQNKIWREIDRMSYRNQQYPGTISDLVQPSSQHLYRQLRKVPLAHTGMSFLGGCCSGSPFRILHERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3G5</accession>
    <name>A0A2R6S3G5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3G5"/>
    <dbReference type="STRING" id="98765.A0A2R6S3G5"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="462"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="737" mass="81980" checksum="E05365BB117EB10E" modified="2018-06-20" version="1">MDAPSLILIPPTPTPLRSLQPSPLSTNTTASSSTVPELTPSAADRDRSSSETTIVTIYSMYEEEVGSWSASDSPLHRHRPSKDLVDISADYRNSYIQPNGRPAEDSGFYDTTYQVMRPASKRMGMGGTRISVLSDDSTQLAYSDSRPPSSYVRTSSGTRITSDYLSEGPHRSRVISAEGDALSVPRSRPSSSGQPSRPQSQHEISNPSLRSHTQASAQPSSSQWPISRPLSSVSSASPATSPPSSPPIPSLPYPQTSPLLTVPSTPTSSPQKRTNKSSTPDSKHSQLSLVPSEGEDPDSFHVRSTYAQLDLCGVRGDGIDEGVERTRARVGGSRASELRAEEALADEHEKTRELTQEEARLLGSLDRYGFFVIPSHERLILLPRAPLSKTLSRVPASNIQAPANAPILRAQPPSPAPVKELERTAKWSRMLVARSRDEGGNVDLWDIKPSKEQKLRERTFKGIPDCWRSAAWEVLMNRFTRTGKAELRKLAEDYRDALDQPSSYDVQIDLDVPRTISGHVMFRTRYGQGQRSLFHVLHCLSLRCDTCGYCQGMGPIAATLLCYFDPERVFASLVRIHDAYSMHDIFSPGFPGLLEAIYVQERIMEQMMPDVYAAFKKHMISTTSYATKWYITLFANSVPFQAQLRLWDAFLLEGHDIFVLVAVAIVWVYRDHITSTSANFETVLSLLSSFFVPEDENALLFWIEKVTADKKLRSNMRQWRQDWKRLVAEGKDGSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3I3</accession>
    <name>A0A2R6S3I3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TrmE-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3I3"/>
    <dbReference type="STRING" id="98765.A0A2R6S3I3"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="5">
        <location>
            <begin position="324"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS36847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="679" mass="74501" checksum="B979B54F2C472288" modified="2018-06-20" version="1">MATSCSLRHGLIKNSLVLVSALRRPEVKSRGYALYSPLASSSRQSRLSAVSRNPQVAPGVLRNLSQDTSGGNANSELVRSDAQRRTIYALSTPPGKAGIAVIRISGPDALDLWRSMVSISSRKGKSRELDPEPWKMYRCDVSHPKNGELLDTGLAVYFKGKLFSQYSCISRSHMHSGPKSFTGEDVVELHVHSGRAIISSILDALALAPTCRLAEPGEFTRRAFEAGRLDLTEVEGLHDLINAETATQRRAALQAVGGKLRAHFEALRSDVLRSLSLVEALIDFGEEDVEESVYIEAQDLAARAIRQIYTHLSEYRRGEIMRSGVKLAIFGPPNAGKSSLLNCLAQREAAIVTNVPGTTRDVLEISLDIGGLPVIVADTAGLRNTDDVVEKIGVERALQAVQHADITLCVLSLIEALQDPNAEDPCLAIPENISAMISDDNTFLLLNKSDLISPLDARFARSLELQAQKLLGVKKVWAVSLTTSEGIEMFLEEFGDSLRKRFDVLPSASDSAGHLIINSRHRAHLETASHFLQAFLDDYTKADPLYVFAFLRTFIDILREYFGQISAETLKDNFDIVYQVRLITIRRSTASYDAQLLEETLDAGGHPSTTYSNALRDIVIPPSLLQKMLSVAGVSALANPSSNSHPFASPIPWRKAGVRYNNNEIFFDISEELRAVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S434</accession>
    <name>A0A2R6S434_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S434"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="429" mass="48035" checksum="ACDE7DACED0733C1" modified="2018-06-20" version="1">MEPYVGCIYVPTQIRTPQEAIASISDTKARFMNQDTVPLVYVPEYEHSEYVRVLEIALKHVDTLDRNLHKLYLFYDKALFDEMVLTIVSMQWQRRLLTMPLGPQYILSLADLRKLTELLDKEELISQSILDWTVSKEGTYHRRIVNRAHAEMLASFNAWVEITRASFQHPDHQSTLALASSIHDTPGPSTIHTLRATVPSVHRRPSPIVVPAPPLRCTTSDIGQFSSHSVPNNGYLRPPLSPFRRHRGLPQFGDPGFDRPHAYSSSPSPSIPSIGKRTRDEDSYYPSWHALDRPTKRRRLSVGSEATLVNSSSGSSDVFSMGCSDTISLVGRGFERPFCCEDSVSSSSSDSDDSFSCYSDLSVEEDEPTVSAPPVNARETSSAVKRPFLAPMNFGGVPSQENIIQTLQAYYRNPRIAKCNNASYCHIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Q5</accession>
    <name>A0A2R6S4Q5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000079">
        <property type="protein sequence ID" value="PSS37199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Q5"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Q5"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015323629" description="GH16 domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="6">
        <location>
            <begin position="143"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="457" mass="47720" checksum="73F09BF270160483" modified="2018-06-20" version="1">MYLHLPLLLFLLAHATQSEANVLARSSESIVRVATRAHRRAVKGSAGLARDLRLSFRGILADTQQPAAISNSRIYCVSSSGFSSGGNGSEIANGGTTSVGFEPISTNVPFSGSSSGSSASSTSKLTGTTGTGTATGSGSKPTSSAGATSSPWKIVQSYQGSSFFNGWDFFTESDPTHGTVNYVDQNTAQSANLTSINGAGHAIMSVETTPTVASVRQSVRITTQFTYTGGLVIMDSVHMPTGCGTWPAFWSNGPNWPAGGEIDIVEGVNDYTNNQATIHTNPGCSMPSSSSSALNITGDVVSTTDCAAAETGNAGCGIRSADTKSYGATFNSNNGGVYAMMWTNDGISVYFFERNSIPSDITNNAPLPDGWGQPMAFWPASTCSPFQFFNSHSAIFDTTLCGDWASGVWGSAGVPGQAQSCAQITGVPTCQQFVQQNGAAFAQAYWEVKYVQIYQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Y8</accession>
    <name>A0A2R6S4Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v837</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Y8"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Y8"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="236"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS37360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="530" mass="59090" checksum="1038F8D6B9ED3E15" modified="2018-06-20" version="1">MAEAIQQLILDTLHQHGTIKDTRTLTLPGYNEPAATHDGQIILLGALNSLSSRDMVTYTTHETMSHVLTSEGSSIAMNGSHEARVWSALPSKEQRPPLTPKELERKIGSEVAKIGQGRAFKNKWIVKEGDGLVRLTESIDDTTQKDMREVDSTGTLKAGEKALAELRKRKLIVPKKGQWFTVHKGSNFSTSTAKPETDLTVDMLTSGAWKTASFKKYNFDAEGMPTNGGGFHPLLKVREEVRNIFLEMGFAEMPTSSFVESGFWCFDSLFVPQQHPAREVQDTFYLSDPSTSLPPPADYYARVSKVHEHGGFGSSGYRAPWSDAESRKLLLRTHTTASSAAMLYKLAARCRGEDDLEADALAAHSGTTRKGKESGDGDGFRPAKLFSIDRVFRNETMDATHLAEFHQVEGVVADRDLTLADLIGFMRVFFKKMGLENIRFKPAYNPYTEPSLEIFAFHPQLRKWVEVGNSGMFRPEMLEPMGFPKDVHVHGWGIGLERPTMIRYGISNIRTLVGHKVPIENVEKSPAVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5A8</accession>
    <name>A0A2R6S5A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5A8"/>
    <dbReference type="OrthoDB" id="2976199at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="236" mass="26935" checksum="7CD498F0B7ABEDCD" modified="2018-06-20" version="1">MTEYDYSPEGYERYIATQNRVSNWVSDQVSRTPQHQAPFVARSVSQPPLQTRHSSSSTRDRHHSPSSSRSSSRPPPRRMHTTDVYHQSSRSGHASPPQYPPQYYQTTSPLSYAPPVPLPQGHNAMYKTYEYDHNTREIVLPPPRRGETYVIIPPNGRRVEVVKGRKHEESFLEVLTSRTGESILGKTKKHGGKKLVKSENEPRDAAEWWALPLTTPHAAPQASTWMICEKTRKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5X4</accession>
    <name>A0A2R6S5X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5X4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="7138" checksum="479608CB7C7B287A" modified="2018-06-20" version="1">MDRLYGREVGGTAKSMKEVKKESGRGCERLKTLEREDHLSVHFRQTLCEYCAKITPSPQTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S663</accession>
    <name>A0A2R6S663_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S663"/>
    <dbReference type="STRING" id="98765.A0A2R6S663"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="326"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="654" mass="70917" checksum="B71A2A614EC1E508" modified="2018-06-20" version="1">MDEGDLAKLEDSASESEGEDYLWVTRRRPCRLSRLESGDPLTLHLHRGKTSLHAQTASRSRSAPPSSLPSKPHLQSLLTRKGDISFAKAMLSTATTVDLTFDDDDWTAPPAAAKLYRAASVGNSWGVTSIGRGFDWRALDEQKENSKWDHEPRIHLESHSGNHPQTSQLPKTRSAWVSAPTIPKALGSPPIITTLSTVAPAPIPSYASGSFISCSPVQSRCSSPRPLSPANSFVSGRSPLLRSPSSPRIPGTPRSRRRSSQQRVSLIAGRVSIIPAEPPSPPPSGPQKLVRSGSTASFLSVASSAGPPTPGVDKAPTVGERSISEFVIEREIGRGAYGLVKRAREMQDDGSLGPPLVIKQIIKSRILADCWKRHPKYGTIPIEIYVMSAISSTAYVLPPRRPWDPSRSHPETDGFWVEGKVVNGHPNICPLLDFFEDNHYYYLILPSTTSEPVPNEPPPPSDLFDLVESYPHGLPISAVRSYLGQIADALCFLHSKGIVHRDIKDENVVLGPAGKCVLIDFGSSGLVKRGGWDTFSGTLDYAGPEILRGERYQGKEQDVWAFGVVAYVMLVGECPFTTAAEAQEGLESPFSNAAIALDERCMEKQKDGEEPDGGCALGDAAALVRACLQLEVNARPTFEKILQCRFLNGDGGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6S9</accession>
    <name>A0A2R6S6S9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6S9"/>
    <dbReference type="STRING" id="98765.A0A2R6S6S9"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="21057" checksum="D637592AFD8A37A1" modified="2018-06-20" version="1">MIRFDTLPPEVMQAMCTPMHLILPPSPSSHTGALYLGSFSAILDPSLLSSNHIAALVQVLDAPWLPSVDAHAAQGVKLECYRLDILDSTTADLKPHLEATVRWIDERLRKGINVLVHCQQGVSRSAAVVIAYLIYTHNMSYDAALDLVKRKRACVKPNSGFVRHVIVPFYLLPISACKNGNDSGVHLPVIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S786</accession>
    <name>A0A2R6S786_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000001">
        <property type="protein sequence ID" value="PSS38150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S786"/>
    <dbReference type="STRING" id="98765.A0A2R6S786"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43922" checksum="B5589BF0B2342DDF" modified="2018-06-20" version="1">MFQPPGNIFGATLVNQPQGSTIGFGATSSRSQVGSNPVSSLSQPQAPFDPTPNSGPSQSQVPESDPTLNSSQASAPLSRPKPVKAPSIIFQPTDTFGPSAETTEALHDALAQSLGDDGFLDIIFHVFTRKLPSGRVCKPRAVYSNSRILKSSSVYFRGLLSGGFAESTSLSTTGKFPSNQDEYTDAYEFDSDSDLEEGLDDDEVPAVSPIGEPPAPSVIQGIPPSSSAEAASPQLKRAVVIRSAAADTWQALMFYIYTHKVYFLPLQSNGSNMRQQARSDHEKKYLNRPMCSPKSMYRLADIVGIEELKSQAQTYILSQLCADNILEEIFSSFSSEYAEILKEQTDIFCKQYLNDEAMRNLHSKIQVVAEGRCPHGTRAIMSLLEHLPRISGQGGSLKSGGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U7KFP6</accession>
    <name>A0A1U7KFP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U7KFP6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7622" checksum="72553AAADDC331C5" modified="2017-05-10" version="1">MVMKLEPKIYMVGAHALGMDKARRAVRNFPNPPKGDKIALMRPPMLFPLSNPASHVGTLGAEAANITPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEP3</accession>
    <name>A0A2R6NEP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v13285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEP3"/>
    <dbReference type="STRING" id="98765.A0A2R6NEP3"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="187"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR70844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="454" mass="49233" checksum="D08D7DA151818B48" modified="2018-06-20" version="1">MVLPSEPEFEQALNELATSLAPFLKANPEYQKALEIVQIPERIVQFRVVWEDDQGKPQVNRGYRVQYNSALGPYKGGLRLHPSVNLSILKFLGFEQTFKNALSGLSMGGGKGGSDFDPKGKSDNEIRRFCVSFMTELQRHIGADTDVPAGDIGTGAREVAYMFGQYKKLKNEWVGVLTGKGLTWGGSFIRPEATGYGLIYYVEHMIAKYCPEYSFTKSSTLVAVSGSGNVAQYTALKIIELGGTVLSLSDSKGTLIAKEGGFKKGDVEAIADLKLKGGALESLLGEDSFKGRFDYHAGKRPWTLLPKIHVALPCATQNEISGEEAEALIKAGAKIVAEGSNMGSTEQAVHIFEESRKQGGIWYAPGKASNVGGVAVSGLEMAQNSHRLQWSTEEVDQKLKDIMTSCYKICLDAGLKWSGDEKAENGVMPSLLAGANVAGFIKVADAMRAHGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFD9</accession>
    <name>A0A2R6NFD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001297">
        <property type="protein sequence ID" value="PSR70999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFD9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="16421" checksum="2F9B033F5CCF6D34" modified="2018-06-20" version="1">MRLRTAFATRVSQEGGLPYVSPPHWARCQFCCFFEFKLMFGTWTTCITPPSVSHTPYGDGPLVASQASGSGPLQVVAYHWPCRSNSSGGRGPCGSHPFRFIAQIVVFLDLLDIRNHLKGTSCHSYAAITLGKTQVGGNYVVRGTTNLIPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG60</accession>
    <name>A0A2R6NG60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHLCEN_2v12746</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001286">
        <property type="protein sequence ID" value="PSR71370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG60"/>
    <dbReference type="STRING" id="98765.A0A2R6NG60"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="239"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="817"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PSR71370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="928" mass="104433" checksum="453E4D585BDDB0BD" modified="2018-06-20" version="1">MYSTVRRRLFSAFSLNKTVAYGLKTSRREVEASRPVHRQFNTLFTSHTLRTRSRHVPPPTIRHVHIRALSYTSIPRFMLRALRFPIGAATAGAGGLTYANYKFEEVRRKSNEWMNTVQDTATDLFDTASDALKSVTSVVSEVKLPNLETPQFLRDLFHSSEGEGKRKGDGESSGEHQKNNRPDGEDVTIAALVAATMSSPLDSKSESLSSNDPRNGLMHLTRKLIEIRTMLLSIDQSDALKLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGNNMVTRRPIELTLIHTPSQNGREPEEYGEFPALGLGKITDFSQIQKTLTDLNLAVPSTEAVSNDPIDLRIYSSRVPDLTLIDLPGYIQIPSLDQPETLKEKIASLCDRYIREPNIILAVCAADVDLANSPALRASRRVDPLGLRTIGVITKMDLVPAEQGAVILSGNRYPLHLGYVGVVCKPSGKNGKKDSTALVAQRAETDYFGSNREIFGTSSSLMVGTDTLRKRLMDVLESSMASSLHGITNAVQLELEEAQYQFKVQYNDRRITAESYVAETVDMLKARFKEFTTQFRKPQIRAKLKAMLDDKVMDVLEQLYWSDKRTPELTNLAADPKVKAEEVEPYWRYKLEAASSLLTKSGVGRDSTLLVADGIRALIDTIASGEPFTYHPRTAERLIQFSHMILRDRIGVTSDQVENCIKPYKYEIEVDDREWEVGRNEAVQLFEKEVGMCEEKLKEIRKKVGGSRRLNALIGHVKTLEQTEREKRAKLLKGPDENPEAIIEEPTANDYRFPPGHVLDARHAMLYSDRLGILRLRLASLKSKRCRAGPDNDLLCPEAFLSVVANKLAYTSAMFINIELLDHFFYQFPREIDSRLLYDLDRTEIVEFARENPAIRRHLDLQERKDKLEEVMKQLNSLATLRPEVVQPTQRRGRGLFGGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGT8</accession>
    <name>A0A2R6NGT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGT8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGT8"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="14"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="14905" checksum="DBC4EDD92CB2C6CA" modified="2018-06-20" version="1" fragment="single">MSAQMSSYVLINGSLNSTVPAYPADEPSFVPPPFALSINVLWFASLALAVVTASFGILVKQWLREYMTIETSRGAKARLRVRQFRVTALDDWKVYEIAAVLPLLLQFSLGLFFVGLCFFSRSVHPTIGWTITSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHE1</accession>
    <name>A0A2R6NHE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Streptomycin biosynthesis protein StrI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHE1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHE1"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="159"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49221" checksum="CE04BC5C64D92032" modified="2018-06-20" version="1">MRQDAPTHPSEPVTLAVIGCGQRGKAYTEYALRESANFKVIAIAEPRPKTRKNFKDAHLIDQTLVFNTWQELHEASAQTLKTIGTRLSDAIIIAVQDHMHLEVVLAFAEQGYHMLCEKPMSTNVADCIKVETAVKKAGIIFGMGHVLRYSPYTKAITEIIRSGSLGQLINIVHVEPAGYYHFAHSFVRGQWAREKESCFSLMTKSCHDIDILCHWLSPGTPTRVSSFGSLQLFRKASKPAAAGSATRCLECPMEHECAYSAKKIYLESVQQGIAWPANTIVDGIPDIENVTAALRNGSYGQCVYESDNDVCDNQVVNLEFSNGATASFTMVAQTSLICERQTRMHFAFGEIVGDMRTFTVTDFRTRETTKHSPKDEGGGHGGGDLGLIQSFIEAVRTNRQEPLGTDVTDVLRSHLTVFAAETSRLEGRVVDCVAFEKEAREKVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI13</accession>
    <name>A0A2R6NI13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001224">
        <property type="protein sequence ID" value="PSR72024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI13"/>
    <dbReference type="STRING" id="98765.A0A2R6NI13"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50774" checksum="1E2F2AED02676C2C" modified="2018-06-20" version="1" fragment="single">MDAFGTVMSALHAAHKVYEVVKKIRDAPEEIQALQDQTQLLDKILPRIKDVLQREGDSTLVALLVTKAEELTSSVTKFLDKATTTLQDKRKVKKWKWLFRADEAKGLAEKLRAFYGSISAVCAAHSIEFTDDIRASLSELDQRLEESFASIHHRLRDVHAHLDFTLNATLVGVREVVQEELTMSLDVFMYTLVTTLKRELRTMANEQRRGESHNFDRYSVLYDTSDVAQADNVQSTFLGQTSTSAQRDNLPSAMASSASVHHLPPLIPLNEPPCKHCGCQCHRAASIWRTPKSLGWIVGNHYVKIPFPHRLWPDMVQCDVPTCKKGWLMQIRSSLPYLFAQVYMQIRIKVIPVHFCIQTPRVNPDLDTKLGRMVLERGADVFKELLYSRRATINDVDNNGYNLLYLAMWRIERIRTDRQLNNLIDATTYLLEIGVPREWQDDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI85</accession>
    <name>A0A2R6NI85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001214">
        <property type="protein sequence ID" value="PSR72105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI85"/>
    <dbReference type="STRING" id="98765.A0A2R6NI85"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="4">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="544" mass="60136" checksum="72E54CC2FB3F8D7A" modified="2018-06-20" version="1">MKCAAVKKKFLLANKHITKLNSTLSVRIEELNAQISTLYVENLRLRASEIALATQLKKERERSRMIVVEAEAATHNLMKHLGHIRKSFNVPHRRSTTPEAKPLPELRTRRPPHDVNTSPLVPRLARPPTVPGILEEADEYADGGLDEDEPLSPTPIRRKSKSRPSSELPDRSVPLSLDLPIITFDDQLSQTGKRKPTRRQSGLLTSVSITTVTPKSYSDMLPPRPPSPAFGSPLRMEAALEEEEETLEVIQDARRRGEEEEDAEEPLALTITRRDKRKKSKEKEGTVNFGRELLSESSRRELDKRRLREAEDGAGPLTGKKPKLKDVTNAPPPRPSLANLENRDHSPDIELPSSTTSTSYSTGRTFLATPNPTPKPSLPTPRASSPIHPTTDVEPEDIGGVRERRVRKSINYAEPKLNTKMRKPDPTPSTSKRTSITSETIPRRSLDVQSSAPPSSSSTDSGSGSGSYQPPPVTGLKRKKSRVHIPAEDAEESDGTQADAEYGGLRSGSSTGWVNVDGRRRSVHTNVGARRAEGDDLRRHSMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIA2</accession>
    <name>A0A2R6NIA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIA2"/>
    <dbReference type="STRING" id="98765.A0A2R6NIA2"/>
    <dbReference type="OrthoDB" id="2801303at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="1">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="15667" checksum="1D64374441F96FCA" modified="2018-06-20" version="1">MIGAQGTSYRHPAIQEVVIKSWFRNRKDEGISQADFFDAPGIPLPTLALVITAIENALDEWETGIHTQRDFTDKEYAKRYREHLTVLKAWEKLTVERKTMSSRKLQMDILKAAHAAVGISDDDTAPAETVPALDDLASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIB8</accession>
    <name>A0A2R6NIB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001211">
        <property type="protein sequence ID" value="PSR72126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIB8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="5766" checksum="040C68508E24E758" modified="2018-06-20" version="1">MQMHLVETKIIIEVDGDGNNGLKPSPGISQINFNIKGDSLIYLAGSNAGHNSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIE4</accession>
    <name>A0A2R6NIE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAP-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001224">
        <property type="protein sequence ID" value="PSR72028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIE4"/>
    <dbReference type="STRING" id="98765.A0A2R6NIE4"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAP-associated" evidence="4">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="36060" checksum="DA93EF187AD5C243" modified="2018-06-20" version="1">MDGKCDEAELWHVPNSLRILTYFCADIVGQDTTMISILSSGTSAAGNVSALVVADAAEAPDREVSRRRKRKRKRTRGKNPETQRSTPWMDSLPMTEYESKEQSINSNDGVKAIPVIKRYLDEMPALRHLVLVIKAFLAHKGLNSAASGGLGGYATICLAIHLLQVNPGKRPTAHLENPMGNELLGFLLIDFFAYYGDKFRYDTDCVSVTTGSLISKEVKRWNNEQNPDALSIECLLHPDSGELKKRLDGLLLPTAYEPPPNSRYFERSLKHQAHNESIYTWRRYVERYTEAQAPNGGDHWSYDPSRSSYSDERKKRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIH4</accession>
    <name>A0A2R6NIH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIH4"/>
    <dbReference type="STRING" id="98765.A0A2R6NIH4"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9803" checksum="89BD8CD9FC2DD759" modified="2018-06-20" version="1">MNLMLLLYSISPPFLPPPRSTDDMWYAEERLGPERVKGLYAFRSIVDHGGRITLGSDFPVEGVNPLAGFYAAVTRLSPEGTSPHGPEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIL5</accession>
    <name>A0A2R6NIL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIL5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11716" checksum="CB4C84B51420E3BC" modified="2018-06-20" version="1">MCNKCNAKRIAPPEIVKNEQHTYLHALVTCKEKHSEESEVTSTSTEEKIATLEEKVGVLDGKIERLEEYMVRVEKTLAMLLAKLDGYVPPPDQPASAVNGLDHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIN7</accession>
    <name>A0A2R6NIN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001206">
        <property type="protein sequence ID" value="PSR72193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIN7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="23172" checksum="FAD5AA14567D9A25" modified="2018-06-20" version="1">MPPNSSDAADGSDDVGIHLSSFADEDDEIERQDLTMGSNVDLQWDVPVPYVSRKTQKQDAIQLGTHVAYVGSSAIDTAASDLNIRDSESTEHIEGNLAANQQTASTRNSNPRIPTIALTQVHIMKPRLSVTLKSARDREKVTINSQVPSIDKGKASVTQVVGGKATIEGKNTASRRQRFKMRDLPEGMERSFSEELVSCLRGVHQLLKIFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIQ0</accession>
    <name>A0A2R6NIQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIQ0"/>
    <dbReference type="OrthoDB" id="10558691at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="78" mass="8564" checksum="415A4BDF1B156F0C" modified="2018-06-20" version="1">MSNEADRRLKYDRGPVATLMDRKAPDEVKDEARDRLEQLQGSVEPNEGVSAAYGTQNSNAYDGQKAAQDVINTGRHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ42</accession>
    <name>A0A2R6NJ42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001196">
        <property type="protein sequence ID" value="PSR72321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ42"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015311896" evidence="2">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6216" checksum="53879073B54B842B" modified="2018-06-20" version="1">MHAFNTISSIGAAMLLFATLVIASAVPLYTQTPSTSSTWHGPVYPTSSSSTAWSAGTVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ78</accession>
    <name>A0A2R6NJ78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ78"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="325" mass="34837" checksum="D76CD685A7B949BC" modified="2018-06-20" version="1">MSPQLINVDQVKTRLAKLKSASTAQLGKLRRRSKDKEPTATRSPSLPSLRGPSAFSRIFAGHNKRATGDTAARRTSSDCTSVSSTWSQDEDASVTSIDASDEKSVESFATSVTDSTYPRTPAEQSYDDADDVGDKGGDVSVEIEAIEAPYPMPDVLNGSPPPVSPVEPLPSDIDPFSPQFAAVEIPLETIYEDESPSAHITQPAYASLTSLVEDIYSEPLPEQLSRSDDMDALAGSGVSCVAEQEAAIDVWETIEEAADTEAEKEKVQSPIYVIISRSVGTAAADRGTSYVDMLPPVLRLCALRVQSTSSVAYQLETSPEDDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ94</accession>
    <name>A0A2R6NJ94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein Sm D2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v11756</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NJ94"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="15">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SEC7" evidence="14">
        <location>
            <begin position="611"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="922"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="226"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="596"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1081"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1165"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1330"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1468"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1167"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1332"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1388"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1401"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1416"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1472"/>
            <end position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR72413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1513" mass="166072" checksum="65FDB07F2DA736F7" modified="2018-06-20" version="1">MSQYVHVPKSELDEAQLRALEEHEISQGPLSVLQQAVRNHAQVLISLRNNKKLLARVKAFDRHSNMVLENVKEMWTEVPKGKNKKPVNKDRFISKMFLRGDSVILNDDSQHLIGGMVGLFHLGNKASPSRTARSSSSTRPLTPPPPPYGQNGPHPPPVFASETTTTTTHVVTTTTLTTTHFFSLPLWRRRAQQSATLNNPAPDTGANQAADELGTIHSVSTPAVLMRDKDLPPTPPSDGESLASCSRRTAQYADRDAADDSRTSIHVSRSSSAQRLPPSTHSEPVAGPTATLARVALGLGLPPLMLDPSLGSAESSSDINTVSFVASPITAPVPVPRASSSSMRRAKSFQKDTSIPAGTSHSEFTERRRTRGFSLGPLQLGSEEKGKEKEPERKSLSRKGSFWSRKRNDSRTPTPAVPLPSEQYLQRPSLPSLQPVSPFRIDTDHQSSSLRPDDPNAPHASELRRRHSERTASQAEKSPPHTPSQPTSPKSSHLLRRPQSKRPQTADSAGSPRAVSSFFPSPTSASSLSSGPILTPPGQNNESVSPISPVPQITTSRPRSQTNPPFLHRLSMNLFGPSSTPSPVNGSAIMDDLHTTASPRTSMSSGSRLSVSRPSPKVSVEIPRPRHEEESPEVYLERLLEAVSKAEVATVLASSADEFHAHALRSYISRFNFSGDPLDVALRRLLMDVGLPKETQQIDRVIEAFAACYRYRHPQLFTSDDHPYVLAFSLIMLHTDAFNKSNKRKMSKADYVKNTRLPGVPAEVLDCFYDNIVFAPFIFIEDPLDVNGQRGLLPDGPSRRLSTLNAPSPGGLNGSGSTLLGKTSKIDPYYLITRNLLDDLRVDVRSYVPPASPYYYLGTAGPWDEDKLLQSFATANVVELASENRYLSAPWFGLNVGGGPASIAMSAAPTYPPIVPIVASLKVTKVGLLFRKDEVLEGGRKASSRKWKEMSVLLTGSQLLFSRDPTWAGAVQAQSDPTNGQVSFPHGLVPRPDELLSVKDAVAVYDRSYTKYDNTLRLALPDGRHFLFKAKDDREMNEWIACINYASAFKTAGVRMRSLGMSGQDIELTGQAAAVSHLRDLQQKEKPTMSPRIRSYGRPSTDVEQIVDGPTSPTSDPDEPTTPPMENSSRLFKATFDQVKADLASGNWQSLDAMSLHSSGRPRAYSLESTLNSPTSPASKTQENGERLRLSSRAQIIRSKVHDLDTRLALQQSQLDSDMRFVQNMAVLTPFQRATRDRLQLAVQNVAKRVMQVRLDLEKLKCHRDVLSKDLAAEERDWQRTKNMALRAATEKLQVERKQSLPRMTLSMYMDEVNDPVSSPIDIPRNSEMADSLQTEASATALSRSAPEYHTDWTSYSPDDQRQTLPVGDTSHILDSPTATVLSKTSPSRPPSFPDSPRPSQLSTQSSIESTIGTPDEGRTSEDKFYSAPETPEEQAEEWNKTRAAKRVSLVRLPSDLRMTALFGRHARTGSEVVSSDASTITPSTRSNRSASSPTSPFGRTNSTVDNVAMLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJQ2</accession>
    <name>A0A2R6NJQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001155">
        <property type="protein sequence ID" value="PSR72541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NJQ2"/>
    <dbReference type="OrthoDB" id="2749024at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015337039" description="DUF6532 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6532" evidence="3">
        <location>
            <begin position="289"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="491" mass="54970" checksum="E975E1BE0DCABB5D" modified="2018-06-20" version="1">MNKAYTLFNLFLSFILAKNPHGYPVKANLKASQRITAEINDGDDDPESGSANESKLSGEESSSYAPSEDDDDLRVTAERGNYAIKEKLQREKPQWVRPLVIANNNEGAADVDDNTLMDINQLPMHGSRSRRSSTSSGGAPLSTSPGVSDEDDDKVIEPEHGPRITSAKSHREKAVEAERPCFKDSETQKGLTPTPNNTGNRSGEPSQAAYVHGRKLQHKRRETIHDAVEGELKWPAQTRLAYVSVNKINKKDQSATIQCILTREIIDFTVDFSFAQAIYRADDRIFYQQKLAIDAARQLGYEEAALRLQEDLHYAKVMIDVGETRLGIIRGRMKKTAAGLTPVVFHLEEGACERRVARLLLDCQFVYPGDVEKSLDFKNPFDITIITAVLAAHFFNGPNSIASQHRQHLKSSIPEKPHEKEIPEAMLAMACAAIALALLDWDSGRYMPARDFNIAYAKRVYGLAIGIMHYIKEKSVNMYHRVMHKVYGNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKB6</accession>
    <name>A0A2R6NKB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NKB6"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="8998" checksum="EB60125216C60F4D" modified="2018-06-20" version="1">MSTYDAASQQGTPYAYTPVAAGSSSQLATPDLSQVASTSTQLPLPAQPAPPQSRQAAEEARKDRTLAEFLLMLDDYEPLVRSGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKD5</accession>
    <name>A0A2R6NKD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKD5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="10819" checksum="CD0A7C36277D4F64" modified="2018-06-20" version="1">MSRSPTDSMRMVAIAPDVPGSVPYGMNGDFSRMSIISSPEASKSSPLDSGVAFVKGGKRKRLSKLLAVTAILLQRSVHTRTRAVAPFQHLEIPTLTGPQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKJ6</accession>
    <name>A0A2R6NKJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v11250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 11"/>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKJ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NKJ6"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="158"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="30"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR72883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="328" mass="34326" checksum="C94F17F7C28931E0" modified="2018-06-20" version="1">MLARSALRTLSQSRQFSSSASRQTKVAVLGAGGGIGQPLSLLLKLNPLVSELSLYDIRGAPGVAADVSHIDSASEVYGYPADQLDKALEGVKVVVIPAGVPRKTNASIVRDLAAAVARVAPEAHLLIISNPVNSTVPIVSEVLKKAGVYDARRVFGVTTLDVVRSARFLGSVTSSNPDDCKVTVVGGHSGPTIVPLLSQTANGKAVKGEAYEKLVHRIQFGGDEVVKAKDGAGSATLSMAYAGAKFTNDLLRGLNGEKGVVVPTFVKSPLFEDKGIEYFSSSVELGPNGVEKIHPLGSLSAEEEKLLEACLPELKKNIEKGKAFVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKV7</accession>
    <name>A0A2R6NKV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKV7"/>
    <dbReference type="STRING" id="98765.A0A2R6NKV7"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="12855" checksum="84AC88EF3AC4719A" modified="2018-06-20" version="1">MRQIPESCVSWWAEFLDVYDRFTDRAFGPGLKLDSYHLQLFGVAPEHHRKGVACALVQAVEQIAEPQHLPMCVETTHPSVISIYEKLGFHLVGTEMYKRADGSQGQVSALLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL30</accession>
    <name>A0A2R6NL30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL30"/>
    <dbReference type="STRING" id="98765.A0A2R6NL30"/>
    <dbReference type="OrthoDB" id="3268051at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015320662" evidence="1">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="15821" checksum="3CD3AAD4A24C50C7" modified="2018-06-20" version="1">MRGICSLVSFLALALTTVTANFTLIQEYSGSTFFDKWDFAADLGQYYDNTTSGDVFWLGKANSSSLAYVDSTTGHAIIRIDNTTFVPYNDKRNSVRIYHLYTVTTKVALSIEHHRYESRPRTTSTTVPSGFLMHTTSPGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL77</accession>
    <name>A0A2R6NL77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydantoinase B/oxoprolinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001105">
        <property type="protein sequence ID" value="PSR73125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL77"/>
    <dbReference type="STRING" id="98765.A0A2R6NL77"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="591" mass="63604" checksum="A6EA2D800673E66B" modified="2018-06-20" version="1">MVAPTNSKGPDPILLTLFANRFMSVAEAMGRSLQQTAISTNIKERLDFSCALFAPDGDLVANAPFIPIHLGSMSFAVKYQMKLHGKDLKPGDVLMTNSPHAGGSHLPDITIISPVFDDNSKEIIFFTASRGHHADIGGILPGSMPPTSTSIFEEGAHIVSFKIVREGMFDRDGLIRYMIDEPSQYPGSSGCRNIRDVESDLKAQIAANHKGIQLIKAIVEDYGLETVQEYMYHIRSNAENSVRNLLRDVAKRAGTNVLESVDYLDDGSPIQLRVEINEKEGSAYFDFSGTGCEVRGNLNSPISVVHSAVIYCMRAMLDMDIPLNAGCLVPLTINIPEGSLLSPSLTAAVCGGNVLTSQRIVDVVLKAFHACAASQGCTNNLTFGAGGKDKDGNNISGWGYYETIAGGSGAGPSWHGTSGVHTHITNTRIGDVEILERRYPVMIHKFGLRAGSGGKGEFNGGDGVVRDIEFTEPLQVSILSERRTRQPYGLEGGEPGALGRNTWVKQARKQDGDLSEDHSNKEPLKPRNINIGGKATVWMGKGDRLVIETPGAGAWGAPPDVEKERDPGHSHVKAWAARGSLAEREAAQAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLJ4</accession>
    <name>A0A2R6NLJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001095">
        <property type="protein sequence ID" value="PSR73247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLJ4"/>
    <dbReference type="OrthoDB" id="10007757at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015334175" evidence="1">
        <location>
            <begin position="23"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="26583" checksum="AB6EAA529634444A" modified="2018-06-20" version="1">MTARQVPLVSLFLSLFLSLISGTYHVSATSTPPSKDLNIPTVVDLRIEGQNRTIFSGPIRTRGHNVTSASGVTLHCDGTNNHTNPTPGPTCTSALDDASKQAGFSWDGELFTEFDDFLITRIARSEQTATEFWGILVDFQFTPVGGCQQQVKHGDKVLFAFNAFNKTHFLSLAGPKAAAVNSSTTFAVTDGASGEKIANATVVTLRGGPVGITNADGEVSLEFGKTGIHVVKAFREDSIRSNHVKLVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM03</accession>
    <name>A0A2R6NM03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM03"/>
    <dbReference type="STRING" id="98765.A0A2R6NM03"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015339894" description="TRP C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="4">
        <location>
            <begin position="256"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109173" checksum="0E73DDF56B21A947" modified="2018-06-20" version="1">MAGFRSEHALLQMLLFLILSVFYIPRVLAQPATIQFQDCFSDDSTDRKLSISNVYAQLLELPHGGLLNFTVIGETPQQIVESSNSSNPVATTLFTTSSTLTFNVWNNNSYFCSTLRPPSPLPEPNNLTNNYCPLPAGPFALSSSIQLGKGYALATYNTRLRALDPVQRELLCIDLSTTPLLPNALDPVYGDAHIIFWSTVALAIVYWLVVGLARLVSAWGRGSTRSGRGFWAKVESTGFVLASAISGERLATSPALMRFCTPSLRDIIFHSQWCAALAMVAVQWPDFIYPLLSQTAWSTLSYNISLTQGSAAKADHWNPLSVEPYNAPTNFVDQLNDPASPIYINASSPNLLFQLPSNATSGLESFAYAVGLRPEDLFGICLSLFLAIMAATIVLSVVVWGIDWIVSLLSGRFTQTAATLNGSRSPRYSSASKDLLEGVGQLQNSEENRSLSGHALFRSTSRFPFARPWWRLRSSFVSFHGSILQGNLIRILILFHLPVTIFSCYQMTVGRSKASLASIILAALSFAILSVLLPIFLVLRLTFTNTTKLYDETWTLLSLGPLYNHYRHGSQLFACLLFATNLAFGLTIGCGQKSGTAQAIVILVVEVVSALGTSVWLPWGHGASMGLISFLFCVARIVIAVLLVILTPIVSVGSGAAQWVAYAILFILGLIYLAFILMLLVKLIEAIVRICGGVGFHKSKHVVDSGLLGALGLAGCCGSRRPRSYSRSRYRADAPQPATLPLSRPTPPYKDVTPTASGPPSVLRPEHALQPYKEESDDETGFIMGAWQPFPRPGYTPVDDSSPAPPEPPQTGFARVGGGRAHYESPYAIASSSTRGSTQTFPSVDRNIGTSQLNSTVTARDYSPPPTPSISSTTVAKKADLSLPPGALPPAHVRTKSQTAIVEDASTLMNLAELRQAQADYANNAEGEDGSDLLVTPRKRWWRKNRRPSEPEPPQNMPASDPEPGRSFVVVRKQRPGVSPRDSSGPSSEPEQRSFAVLRGNNADAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMD0</accession>
    <name>A0A2R6NMD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMD0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="181" mass="20695" checksum="3A7EE8849510F7E4" modified="2018-06-20" version="1">MGVQSMYTWLSPTGQAQHIKKILDETRVFMTQLKEQVPSGMVGEASNWTTIAVLEERLSDCEAQYKLLLEEIPKSGWAELYSILVGLRDLLKLCCTVRTDVLKTTNTVYKENKLRDQRQAVVEAQTRAQISEWMRSGLAPTRYAKVDGELKMKLDRRKVRVPVVGRRPGKRRFSFGCSAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NME3</accession>
    <name>A0A2R6NME3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001070">
        <property type="protein sequence ID" value="PSR73517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NME3"/>
    <dbReference type="STRING" id="98765.A0A2R6NME3"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="16283" checksum="EE29DFD49F849B4C" modified="2018-06-20" version="1">MPLLRRPANHDDHLDIDDENDAIDPQLRLRTVRTAHSTLEESMRTEDRAQRRKTMRRKKSRGFFRRGTDKKRAEKAESIAESTEPAAAPPATGLRRNIYVNTPLPPDELDLHGEPIVRYVRNKVRTSSEYRHYQQIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN27</accession>
    <name>A0A2R6NN27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN27"/>
    <dbReference type="STRING" id="98765.A0A2R6NN27"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="88"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="401"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR73781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="581" mass="64186" checksum="228792FB778F22D6" modified="2018-06-20" version="1">MVRRIAVSPSAQDVTLSYLTSTTSIFLLGFVTFSQRLQFTDIILATCLCYGMRPDHRHRSTESPYASISHIARTYLKSILSNPESRKIFYFLVLNMFYMLIQMLYGIWTNSLGLISDAIHMAFDCMAIGVGLIASVMARWSPNERFTYGYGRIETLSGFSNGVFLILISIFIVFEAIERLMDPPEMNTSQLLLVSSLGLAVNLFGMFAMGGHHHHGGHSHSHGHSSHGPEVAKAHDHGHSHDVDQYDHRHAPSHSHDVGHPHDGDHKHEHAHSHSHDVGHPHDGDHKHEHARSHDVGHSHDDDHNLKHEHTGCESHHNKSHQHSESHSSSCSDSHSHAHDEGEHSQHSPGSDSIEETSRLLALRATDLNSPITPSYHFGHDAHYEKHHAHDHTPNLHDHSHVHDHNHEGHSHNMRGVFLHVMADTLGSVGVIISTLLIQYYGWTGFDPIASLFIAILIAASVIPLVVDTGKVLMLELSDSTSGIEGALSNLHQLEGVESYSSARFWPKDDNSVIGSIHVRVAPSSSAVDPGGPHSRVQGQYIKVDRLVEQVDSLLRGRIKGLEELTIQVEGGGGHGATLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNC4</accession>
    <name>A0A2R6NNC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001052">
        <property type="protein sequence ID" value="PSR73887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNC4"/>
    <dbReference type="STRING" id="98765.A0A2R6NNC4"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="305" mass="32784" checksum="67DB3248BFFA714F" modified="2018-06-20" version="1">MSGPAASASGSKLQAFMNHPAGPKTVFFWAPMMKWCLVIAGLKDLTRPASKLSVPQNLGELLRRFNRSGTASPGLAAGTARLVKGDALNAEDVAKGWEKATEDSQYVDLVLFTVGGTPTLSLTKGAVLKIPDLCTHAILNLLRTIPPSHRAASSQPKIIAVSSTGLTPSSHAHHPLPIRALYSWLLPQPHADKLGLERVLAHCVGWEWKAEDGEPREDILPAGWAGQPGTPGQGELKQVLVVRPALLTDGACKADKKAGRAYRVGEEDLENNGYTVSRRDVAHFIVEGALPDWTRWGGKRMSIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNF4</accession>
    <name>A0A2R6NNF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001049">
        <property type="protein sequence ID" value="PSR73930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNF4"/>
    <dbReference type="OrthoDB" id="2797774at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15501" checksum="9CEA055597BDC449" modified="2018-06-20" version="1" fragment="single">NKIELYTFTVIASPTLSSYVTDGYPRQLVMGVLERHPNWGYTKEVREDPLKKKIVLNKVMTRLTDRRSKIKAVIVDSLGAEYPSDPTKNRQPQDILELCQEIAALAGGSLEDDKFKVTLQMCARVALFVSLSSVSQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNR9</accession>
    <name>A0A2R6NNR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001021">
        <property type="protein sequence ID" value="PSR74069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNR9"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR74069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="165" mass="18740" checksum="659DB6579355B242" modified="2018-06-20" version="1">MAATTSGSKRWTHYHSALQLAIQRSAHKWTSLKTELAQQNGCEDLLKKLDAKPNIDRLHAVVTEARAKKQAGYTGSDIWREDLHPSAAARAQIIPLLEEERERLKSQLAEAGKNSDQVIYQLDRRNRALQAEMQTNVKARSAADEESSHLLDMLDEVHFHYLFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPW0</accession>
    <name>A0A2R6NPW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPW0"/>
    <dbReference type="STRING" id="98765.A0A2R6NPW0"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="204"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="467" mass="51855" checksum="4EC4893870C242BF" modified="2018-06-20" version="1">MSYSDFAISIASQFDAPVSSPHLNLIKDLKAAHPDSQHVSILQYSESAFPLSGYLATLDTIPSIDHSETHAVVQYDPGEKIAFTQVVVGASRFTYDSTKFQAYKATWKLDHQIQAFYHLVFQGPDDSVGQKLASEVYIWANSLKEEIWVFEGGMWAKNKQLYKAIHSASWDDIVLKQTFVDGLRRDTQTFFSSKDIYLSLGITWKRGILLLGPPGNGKTESIKALLNESDCATLYVKSFVTRGGPEQGVRAIFDHARKHSPCILVLEDLDAMVTDEVRSFFLNELDGLAQNDGILTIATTNHPERIDDAILNRPSRFDVKYDFTLPDSELRKAFALKWIAKICSLGTETGISFEEPEEIASAVAEKTEGWSFAILKELFVSFLLRVAHDKALRNKGAEVPLEPAHVLLLKQVDQLAAQIIKSKDDVAEAKQPGVAHPSAYRSVRAVPAMFQMPVSMGGMSVHPGTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQC3</accession>
    <name>A0A2R6NQC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000964">
        <property type="protein sequence ID" value="PSR74690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQC3"/>
    <dbReference type="OrthoDB" id="2738198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="201"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1042" mass="117048" checksum="10C812EDD2F9B0BA" modified="2018-06-20" version="1">MAGETTSSRMPKSSPRKGWLPAISRLMTSSSKPKESRSKPTFDPWAAMRQKPPTDSSTPGASHPLPGPHQVHPGPTIDSAVGEDSYPALPADEEKPSVPTMGPKKAKTNNTIKPSVRSTKFLSYWGKRALEALLRREAGPRKSLDCAQCGERAFDLVYRCTTCFHPPILCSKCLVSTHMLGPLHVVEEWKGARGFWLRCTLAELGLVVELGHGGKRCPRTLSSTRLMAVVDSHGIQDVRVRFCGCLVDNGGAIPDATQLLEAGMWPAFTLQVMREYHLLAMQAHTNALDFFNVIKRLTDDIAPDEADDRYREFLTATREYFFINLCRSKGVSPTFGMDSASLATLCPACPQIGINMDPDWRRRQVDKRFLDALFHAVDGNFTQNQKDKKMDIDDFPLTLGAAYFANESDVSLFMEGLPPYKPERWMDLPVHVSAYDINCQYRINFAERMETFRGLTTEFKSIRRKFFPWTIAGVGKFHLFAHIFSCRYKYSFNFLPGVGMTDGECVERIWSALNGLGLRTREMASGHRHDTINYFYDDMNVRKTQTIGKYQEADKMYSRADSTLEKLEGDISEGILGSGKLAQWKAEEAEWLSKVVKQDTHKTLDNPYEPKKEKRLTQKQALAEIGAKMLSSSVVSAGLLGVLEEGIGLEESRYGGKASTMLLELDMGANSDVSMKALEDLRSHWERDLESWRGREATYLAPLVQEAVKVLDERSRTTALRSGPEGGTSEASIIGDGDSDVTDSEHDHLEDISTSQPVTGAKRKRGTAVSGRKREQARPAMALELLATRIDLPSSVHRIIRKHPAMKAAVDMEMGLREHQAHDALDDLRTQLITSAGMRQKKQEVSGQNRTTRAAGAIIRKNKAVQAAAASYRRARGALLALGMSTKDEEFRELRKEDVKAFTVLAEEQLLGDSKKSPSWIWENLEFIDARGEGAVKEYFEEAVRVHWFRCSALKTRWLEQMLLLPEEMRRTVRFFQYHKVEWRNKAEAEDSRENPGNAAQARRQVHGYDRFLDGCRQAFCDVPGVDVDMLIASPTNMHDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQL8</accession>
    <name>A0A2R6NQL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-coumarate-CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQL8"/>
    <dbReference type="STRING" id="98765.A0A2R6NQL8"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="464"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="63109" checksum="70B6105EBFEE2F4B" modified="2018-06-20" version="1">MYLKSPFPQLPPIPDANVHEYMFNTPEVQNLADYTLYIDAVTGRKRSWYDFRDTVYDGATALGAPVSQGGLGLNGDDGDIVGIFSHNCMDYIALVHSLLVITTPISLLSAYSTAFELAQALRTSKVTRLFVQPSFFEKAKSAAKDVGLSEDRIYILDGHIEAKRSYQDLVDDVRRRGIPRVPVKRATKDTLAYLVFSSGTSGLPKAVMISHGNLWAILVGNVMTRDEEEKITKPTPPASPPVWLLFLPFYHTYGVHMACFRSFARPMTYVVVPKWDADLVLRSIPKFLVNVLPLIPSAIHQLVNHKLIDKTDLSSLVSVHSGAAYLPPALSEKLKTFVKNVPHVLEGYGMSEQTLSASRKTYPGMFGLQPKSGSVGVLVPGLEARIVRPDGSEAKVEEPGELWVKGGSVALGYFGNEKATRETFVDGWLKTGDTFKADQDGQLYFVDRAKDTLKVSGAQVSPTEVEDVLLAHPEGLIVDVSVAGVSGGRTSDEKNPRAWVVLSEKGKRRGAEATLKALDDWTRRNLSKYKWLRGGYEVVDQIPKSPTGKVLRRVLQDRYEQQLLASSTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQP5</accession>
    <name>A0A2R6NQP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000949">
        <property type="protein sequence ID" value="PSR74875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQP5"/>
    <dbReference type="STRING" id="98765.A0A2R6NQP5"/>
    <dbReference type="OrthoDB" id="2789130at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="239" mass="27508" checksum="37059A63803B65E6" modified="2018-06-20" version="1" fragment="single">LHKGVSKDHTVKWSTACVDGANNEVDRHFKAMLPHPDLRHFKRGISLILQWTGDEYKNMEKIFVGVVAGAADPEVVHATHTKESLTNLEDAWEAFHKHKAVFIKQGIRKLFNILKLHSMIHYVQSIQLLGSADGYNTEGPKRLHIDFAKLGYRASNCKQYVQQMTAWLEHQEAVRHFEAYLDWLEVSQWDAEEIEDSSDNEEPEDNVEIEEIEESEMVTQGSLRTTHCTYKIAKKPPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQS8</accession>
    <name>A0A2R6NQS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQS8"/>
    <dbReference type="STRING" id="98765.A0A2R6NQS8"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="44"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="542" mass="59337" checksum="E8E7EB2301A1C393" modified="2018-06-20" version="1">MSSEGKLEYNEKVHDGVVEPYPDSEAYVAASGNAPLHRTMKNRHIAMISIGGVIGTGLFLGTATSLQQGGPVGLLLGYAIIGTICYSVMISLGEMVSYLPIPGGHLTMAERFVDSSWSFTLGWNYWYSWTLTLPAELSAASVLINYWNKSVNDAVWITIFLIVVIVINLFGARAYGECEFVFASLKVITITGLIILGIVLDLGGGPNHDRIGFRYWKNPGPFTQFAGIAGSKGRFLAWWAVMTQAAFSFLGTEIVAIAAGEAKNPRRNIPKAIRRVYIRILLFYIGGVTIIGLLVPSNHPDLNLTESNAAKSPFVIAIKAAGIKGLPSVINAVLLTSAWSAASSDLYTSSRALYGLALNGNAPRILTAVSSWGLPYIAVAVNCLFGLLAYMGVKSGSGVVFNWFVNMTSISGLMSWFGITVTYLRFYKGMQAQGMDRNTLPFKGPLQPYLAWYATISSIVVCFFSGFAVFLKGGWDTASFVTNYLPFIIFPILYFASRFYRGSRFINPEDMDFKSGLAEVEAASYDDPPPRNWVERFWGWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSF0</accession>
    <name>A0A2R6NSF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSF0"/>
    <dbReference type="STRING" id="98765.A0A2R6NSF0"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="63583" checksum="57A69C6B23A900FC" modified="2018-06-20" version="1">MSQIFEQHKHALQLQVELNDEDAYDKEESGVPGDAPNTIPSICGLPLKYVSLVTLAVQNALLTLIMHYSRVSAAPSHTYSAAAAVLLTELLKGSISLVVAFTRLDSYAPQYLPNGTPATNSCWNPWLLLARFRRLGKEVFRSDCWKLSIPAILYALPRAVIQNNLQFVAVSNLEAATFQVSYQMKILTTAAFSVLLLRKKLSTTKWLALLFLAIGVGVVQIQNVGHKSAESTEHDMNAFKGFMAVVAACFTSGLAGVYFEMVLKNSTGDLWVRNVQLSLFSLLPALVPIIFSGSSSTTPTSSGWFSTSLFDNFGVWAWATVLTQVLGGLLTALVIKYADNILKGFATSLSIVISFLASVALFSFPITVSFLVGSFVVLIATWLYNQPDTASSSSTTGSEPTATSGRACRSWSWRWRRRTTLTESRNASALELTGGTLSRRASTSSLSSLASFHNNSGSSMSSSHAHAHHSPSKSFPSSPNERDASILGPLLEKNMLAKKKQQQQQQGQFFAAPLRATKKNLARGMALFRSASYAGGGSAEEYYQPLTQMNHSSSAAAAGAPGSSLVASYPGTRPSSALAGSTSRPSMDHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSU3</accession>
    <name>A0A2R6NSU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSU3"/>
    <dbReference type="STRING" id="98765.A0A2R6NSU3"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="238" mass="27095" checksum="DF644F50E671F94E" modified="2018-06-20" version="1">MTRRDRTEVGRMAEKIVATGGFIPDDIMLKVVTSRLELLHNKASSHFRIHRSLSNPVHTQHWILDGFPRTLGQGKLLDEHLRRVASPLSLVVNIDVADEIILSRISDRWVHLQSGRVYNLSYNPPKIAGLDDVTGEPLTKRPDDNPEIFARRLEKFYASTSPLLSYYTTSNSTPLVSLTGATSDEIWPQLDNLLRSSFPSLKERPESQEHKRRTSLSDAILARTEPEIIRREKDHNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT01</accession>
    <name>A0A2R6NT01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000861">
        <property type="protein sequence ID" value="PSR76118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT01"/>
    <dbReference type="OrthoDB" id="2770090at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="106" mass="11924" checksum="A7C2BFAA28FDCFF9" modified="2018-06-20" version="1">MTRGLPHKLTQSLSYLVKERVDYERHRYSGASAWNPKLDPSSVEYKPQVFAQGKRASNRSNGQERQKALGDEAWGALGEVVQMAEGRHGISLGRIVERRGYALLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTW4</accession>
    <name>A0A2R6NTW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTW4"/>
    <dbReference type="OrthoDB" id="3220023at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="12601" checksum="71CDB0DB3C829A5D" modified="2018-06-20" version="1">MSLELLPVAQAQVILNQPMEIGLYTQLTHRSQVAVELRARRIYGCRHCEQSNISLDTEAPLSAPGTTHMSTMQTPAESSTKLKEKTRGSHPKAGQGKPLKLFGFDGFRSHAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUE1</accession>
    <name>A0A2R6NUE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUE1"/>
    <dbReference type="OrthoDB" id="3188871at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13157" checksum="6F463E40CF677E90" modified="2018-06-20" version="1">MSSTAGSVVSPLSAWAETHTNALYQASTQETFDDAYEAYFAKHTEITINGKNVSRAHHKQEIWSDKHDRSEVSATVCFPAVVEVLGLASNSNVGSVAVFLNVTIQFADPVGTLIITASRQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVM0</accession>
    <name>A0A2R6NVM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAPS-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVM0"/>
    <dbReference type="STRING" id="98765.A0A2R6NVM0"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="687"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="492"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR77575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="954" mass="105152" checksum="A25C1D9748A4C96C" modified="2018-06-20" version="1">MDYFQRVDVLQRLLGYVTGQIEGEDIGRFKYPYVATEVLCSEIWSIVETCITHSEQLLIPFWETVLDRSPEDMKTEMVMAAQFAKINMTFLNKKPAEMLVFIQAQPNVVERLLNHIETPTIAELLTRIIQTDELPSCAGVLEWLSRESLMPRLLDLLSPTRTRDMHSAVTDLIKHIISVAAPSPTAGLSDGLSNGPASNRIARELAHRDSIAKLVGYMLTEFPSPTDSLSTGRTEDASDPSPPKLFLDVDSATSSVVQSICIMIELIRQNNSDYFEPYLFHTLRNRLIQVQQQLQMHTQDGRETLERAMTEMVNRMGVVHLGPVLEIMCDKLDILQRYLRGPRSAHDPVPTTIGTLAPLTFERYRICELYAELLHCSNMSLLNRHSDFNHLYDSEGRLQGGLSALEELAQVIAIGTGNDQGDEDIDEEGNEEIEPAHDFPVSAAHESSIDSDEDMSGSSDDEAMEDITMYDATHALNGSTSSLPENPLERFPPATLSSPSNSSPNCNLLTTVHSRLSSGSDSEGSLTRPRSSNSRRSVRKSVAMDTPGAPVLGERLKMRFLETNVLSTALDLFFEFPWNNFLHSVVYDLIHQVLTGRIDIGYNRELAVALFRDARLMHRIVEGSKFNDAASSKPKGVRLGYMGHLMLISDDVVIALQQFPPDLRLQIAQYAPQPDWDEYMTGKYKETKKKDSSLLGGGKPVIAPGMRNGASQWKVDEEDSAADAAADQDLGEENEEGTLRGELKRHIRTTREVSADFGAAPMDDEEDDDDDDESHVGAPHFARYLAQEMQSGEHDSSDENSSDEEEDNGWLAHSTFDIRPPVSARSHGNDRRPLSSSGFDDVFDPGSSSSGVSDPFDDDAFGPFSDAAAASGEDPFTFTSALSEELHDDGSFGDFGDFGDFQSGASGSSAEDSGLLTPTADSWSFASISSTESEDSGSIGRLSESPSEQDLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVN6</accession>
    <name>A0A2R6NVN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7719</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000779">
        <property type="protein sequence ID" value="PSR77735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVN6"/>
    <dbReference type="STRING" id="98765.A0A2R6NVN6"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="99"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR77735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="382" mass="42504" checksum="A22B210796918982" modified="2018-06-20" version="1">MAPTFTKTYLTSPETEQVEQKIAALTLTGAPAPLKLGNALNSFQKSDLTPLIGTEFGKEVQIAELLKAPNTDEIIRDLGILSAYAICALSSQLFLYDIAVSQRGVVFFRDQELTIDEQKRLGTKLGELTGKPASSKLHVHPITEETSELGDEISVISSERNREYVTPRFDRSALSAANWHADITFEPIPSDYAILKVHTVPSLNGQVTGGDTLWASGYEVYDRLSPSFAKYLETLEAVHEARFFQNIAAALGNKLRDGERGSPGNVGSHLEAVHPVIRTNPVTGWKSVFVNPNFTKRIVGVTKDESDTILKHLFSLIQLNHDLQVRFKWEKNSIAIWDNRSNYHTATFDYGQEKRIGDRVVSLGERPYFDPTSKSRREALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVU3</accession>
    <name>A0A2R6NVU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000770">
        <property type="protein sequence ID" value="PSR77869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVU3"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="891" mass="100189" checksum="FC39CE853270B698" modified="2018-06-20" version="1">MAHCDTINHSLRTRASPKTTVLRPFVSASKAAPIPSGATQQISDSARSSSGSGTGDLIVTPPHEEQAIHGAELNDGIEATTSEVSDALMEDIMHSLHGISSGCDAENEEEPVRLAELWDAASRSRVVHAPEVDYYEELLFSLRRGDRLANLHTLSPFETNAGPHEDSEDSFGINIPEHLEPDINAVHTTADVDPNTETYPWPSMADYANPITRFSMQDYPVDCNGAMSQVQHAEKMLLDLPSEFVPPMVRVENESYFVNELLQLRSEEYFIPEHFFFANDLSEALLRAGDYGKEASTGQPELFALGWTATRTANGFVVNMEHRFHTPISEFHRSFDEIRANNIEFGCNFAECSQLWSTKMPHSFREKAQGRMVYSVPIIVFMDDVSGNISKQWNKHHVIYMSNGNMPREMIDKEFCVRFVSLSPHATPMELVDAMRKSICKVASFHTESRKAAEDGITAWDCKYNEEVLLIPYPLLWAGDNPMQAEECSQGGLTCNFFCRTYKVGGTKEYKRTEEGFESLFTSAELRQPEETLTEVLDQLNNALRPGAQTKLSNAVRETGISDTTNTHFLNFIVSLGKELRQLPGSNEEEISRQLQEKFENWLGDDLREGRVNPLLTTPGVNIHQDTPTEILHTVLLGIVKYFWGQTMHIITQKKHLTDIFRAWLESVNTAGLKDPDLRPEYLIQYKGSLIGKHFKSLAQVMPFLVYDLVPKMVMDAWAAIGSLVVLLWHTEIENTQEYLAPSRDTCTAFAEQDIVKHIATGGLWFDNKQKKWMRAGKGIINYVNEHPTQAKLLGIKQDREFEIGRIQLGIPVKDASHKVVNPVPLLWSNTVCGTTAATVSEEPFTERSTYKFYKARSLVVANGDRARIGDHVFYSVDDVGKPDVRDSVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW15</accession>
    <name>A0A2R6NW15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000765">
        <property type="protein sequence ID" value="PSR77971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW15"/>
    <dbReference type="STRING" id="98765.A0A2R6NW15"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="60"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR77971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="287" mass="32283" checksum="373046BB96E704ED" modified="2018-06-20" version="1">MSINPNEDTEFNDALRKHGILPPREPTPPSPSPPPSPTLSDKLRHLTPSELKDASEEAFDEETERLIEEYRKRRLDQLKRLEHAPFGRVYPIGREDYTREVTEASNVDSKDTGMEGKGTGVVCFLYKDALPRSELAFEHIRILAQRHPHTKFVSIVGDKCIANLPDTRLPMLIIYRKGEVLNQVVAWGADRQRRIEGMTRLARLPADFSTHLLAELEAVLILAGAIIPQPKPPSDKDRANEEASDDEDFDNNSSSRMRSAATSTNAQAPKNIRGKTDDSDSDFEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW68</accession>
    <name>A0A2R6NW68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000758">
        <property type="protein sequence ID" value="PSR78114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW68"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7708" checksum="2294477E93B8288C" modified="2018-06-20" version="1">MFCLLDGPKIKGQRSKFVRTTFALQETVAEKWGTSSSSSRHIALPTAYEASPIWGMEVHARSRKVSIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWA2</accession>
    <name>A0A2R6NWA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000760">
        <property type="protein sequence ID" value="PSR78072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWA2"/>
    <dbReference type="STRING" id="98765.A0A2R6NWA2"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50956">
        <property type="entry name" value="Thermostable phytase (3-phytase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytase-like" evidence="1">
        <location>
            <begin position="87"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="421" mass="46408" checksum="BB582D63CB8159BA" modified="2018-06-20" version="1">MCMYEFISGRLLLFISPPLYPSDTTINYQGRQHEIDFILNPYYSSENLTFTQAQETLQLQYKKTLLYTDRRNVKTSGLDTLGVRPAEFGFPFIAVADPVMPIPNSTFSHLSMDNEGLVLNTDGTFWVSDEYGPYIYRFDSSGGLMQTTQPPEAIVPRINGVVNFTSVTGPDTGRAGNQGFECLTVDESTNTLWAMLQSATIQDGGSDKSTSRFTRLLAYGISLPLVLRPVLKAEFVVPLPQNSKGNTLASSEIHFVSEGIVLVLSRDGNGHGDDTTKSKFKSIDLIDIRNATDIHGSKFDSPTHPIATNGTLDSSITPAAYIEFLDMINTTQLARFGLHNGDPADATLIDAKWESIALAPVGDPKFPHDFFLFTAVNAIIIRRQADNDFLTTQGISLGQPYNAGIDNDNQFMVYRVTLPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWA4</accession>
    <name>A0A2R6NWA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWA4"/>
    <dbReference type="STRING" id="98765.A0A2R6NWA4"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="273"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="412" mass="44872" checksum="EDFA3CF7FA25AF0D" modified="2018-06-20" version="1">MPSDGRTVVLPDYSGNRLLTSLGNIEATPLASLSYVDFVTGDILYLTGDARTLVGSEAQAVMPRQNVVSLVTVTGYIFVQDALPVRQRPGTGVERSPYSPPVRLLAEETVSSSSYLDDQITVTLSSIELHSNDLATFTWGTSKPIHILPGQTAILDMTDLVGARQYAHMAAYNPTSVNDDRIRTWTVSSVHLFPEGTKTFSLTMRQKPGGVATGALFSIAHKLAELRPELMKDCRPLNLELKLVGIAGDFILPKSISLGEDTKKMRVSMMWFAGGIGLTPFLSMLKAITRTNTTDDIQWDIVLALSTREPEVLMPLIDAALHGDGTPNLRLVVDVFSANSVPAGVRVRSTDTLNASLVPHNGRISQAYLTGLGDLESRTAYLCGPEPFERSVLEMLAQKGYSKPVIRESFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWE3</accession>
    <name>A0A2R6NWE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWE3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15039" checksum="A3E9AEDC19F2F299" modified="2018-06-20" version="1">MSWNYVITMAYRACGKQPLASRKIGRVGADACQSGPPKSRCIESPDFEDGATNGNEPTEERLSVLQTSVKRGTCSCDDIVKGQLAEKLGSATGRGAKSLRWPHGLSLCYGWRSNTLYHASVEEMHGWGRSYPDLRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXA8</accession>
    <name>A0A2R6NXA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXA8"/>
    <dbReference type="STRING" id="98765.A0A2R6NXA8"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR78567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="20082" checksum="8562BFE93324F5E0" modified="2018-06-20" version="1">MPLQEFQVVGRHLPTEAEPTPKIYRMRIFAPNEVVAKSRFWYFLRQLKKVKKANGEIIGVNVIHEAKPLKVKNFGIWLRYDSRSGTHNMYKEFRELSRAEAVTALYQDMAARHRARFRSIHVLRVVEIEKSEDVRRPYIKQLLTPNLKFPLPHRVTKARSTFIAHRPSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXE9</accession>
    <name>A0A2R6NXE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydroxymethyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXE9"/>
    <dbReference type="STRING" id="98765.A0A2R6NXE9"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7136" checksum="618F4BD1170E7957" modified="2018-06-20" version="1">MEANGSILTNKYSEGLPNARYYGGNEYVDELEILCQKRALQAFHLDPSKWGVNVQPYSGSVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXJ5</accession>
    <name>A0A2R6NXJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Organic hydroperoxide resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXJ5"/>
    <dbReference type="OrthoDB" id="60422at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797:SF2">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18234" checksum="54E14F50DA93F56C" modified="2018-06-20" version="1">MRPAQVVFGPLVARVMNGAAGRYTQFPNALHRRNMITLKDHLYFAKATAEGAGRNGIVKSTGDSPLELKLAMPKVAAGKGDGQNPEQLFAMGYSSCFLGALQLAASRADQKEMAENAKITASVFLGHPTDPDMDGFGLRVELNVEGCDDDAIIQAAHDVGSPMHSDNPAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXY6</accession>
    <name>A0A2R6NXY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXY6"/>
    <dbReference type="STRING" id="98765.A0A2R6NXY6"/>
    <dbReference type="OrthoDB" id="3219336at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="175"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR79630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="317" mass="35821" checksum="77E7D78DEF60120F" modified="2018-06-20" version="1">MPATRSAGSRRPLRPQPALPNTSAEIIVLSSDSEESLPRKVVPTRKSVKPKGKVRAKPCASPEDIIELTSGDEAPSAPSRKRSPHRSLQSKDQNSERRTENLENENRWLKEELRKFTTKAPSSNLKGTDLDRLRELEATVARSEKVRYGIQNERSPSTKYLSPQTMENLVEHITCEICTLRMWSPYTLSCGHTFCLNCLQDWFSTALVQHMTAHPNWTVNPRLPDRIRTHLNNPNLSEQQRQTANRQVQAMHIATPQPKYTCPSCRHPVTSKPSEVFIIKDVVRTIAGAEGEKSPKRNTAGRRPTESPWDGFFPTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYI8</accession>
    <name>A0A2R6NYI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYI8"/>
    <dbReference type="STRING" id="98765.A0A2R6NYI8"/>
    <dbReference type="OrthoDB" id="2802795at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="11321" checksum="8B0D6906B934B9ED" modified="2018-06-20" version="1">MKSCLKRSTSAPEVLYQARPGVSGDAQSKEQNRKSVSFSEDGEEEVFYAEDWDRSPAAVTQRLTYRDVYELKELRMALPRINLTNEHRLRNAAPISKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYJ8</accession>
    <name>A0A2R6NYJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000655">
        <property type="protein sequence ID" value="PSR80402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYJ8"/>
    <dbReference type="OrthoDB" id="10619883at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7516" checksum="FBAB9E0310FBA739" modified="2018-06-20" version="1">MVVTIGTPTLVHPVSFPALSTVCGHEDEVRVETTGSIVLILSEKEVDELLVMKVTYRVSVGVGVHDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZD2</accession>
    <name>A0A2R6NZD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZD2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7383" checksum="165089B732ABB1FC" modified="2018-06-20" version="1">MSVPPTGPVEIVLPALDSTFGALLIGSTLGAAYVSSVFPCMLALLTLLRLGTRLWGVGTLQLYLYDIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZF5</accession>
    <name>A0A2R6NZF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v6522</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZF5"/>
    <dbReference type="STRING" id="98765.A0A2R6NZF5"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="12">
        <location>
            <begin position="428"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="562"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="103"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="238"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="506"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR81187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="592" mass="67625" checksum="FFECBAEB275C50E3" modified="2018-06-20" version="1">MSYTDISLSELQKTLDVQGIEVVENQKESVVGRKALADRTKEFKKIPDDEKPHAYKGLLKSYQTEIDNLTKRSKSAENAFLNVYKILAEAPDPYPLLEAAVDQTVKVAEAKEFENELKRLREENDELRKRLNETSSLETAKKKAETRVEQLEQRMDEMIQEKVTQKENELNATYDEKMRNYEEREQDLQKQVGLLKGQLRDLRTSHESNQAKLLGHTQRQDEEVVTKLAELDMMVSDLERANSRVVTVERRNELLRAEIEAIKSGNQSSDRLQELKSRVTDLESETDRLSSTLESQKAITLEAQAAAAKRIEELSRDIQRKITEVDQLRHKLKHYDDYDEIKRELEIMKYVEFAGFEEGGDGEDAPVNGSEFSDALGLHLPNPNADKANAQRGKSLEVLLATKNQRILAELTKFRNLHGELEASFQASQYELATVQTELEKQRALNERLENDLLHMETHNTKTVNGDTTPADTDALAGLELGKKVTASPARSSPIPFTSSADTSILPIVTSQRDRFRQRNAELEEELRKQFNIISELRAEVKSLQADNLKLYEKVRYMQSYREDSAHRPSTLDPIPSSSAGRSDDMSKYRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Q8</accession>
    <name>A0A2R6P1Q8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000555">
        <property type="protein sequence ID" value="PSR83649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Q8"/>
    <dbReference type="STRING" id="98765.A0A2R6P1Q8"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="251" mass="28091" checksum="A771C74B469B8D34" modified="2018-06-20" version="1">MSLLQDVLRTQTLDSLDKTLAAVPSSQQIETDSDDELVNVVSIPGTPARSRPASRPASRAASPSRGAKKTLRGTALLSSHPSTDPLKAFPTEISQRIFGHFSISELAKCARVSRKWSRSQTINYVWFQNYRKEHFHDDHLPPGKWSKRESKQNWRITYLNVIAARERESLSYSRPQSRASGTGSGYQTPQELREEKWKSEAEGQIKPSKVEMRELYKELGGRKVRGKGKISTGGTRDKGGWGEDAGGTEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1R6</accession>
    <name>A0A2R6P1R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000555">
        <property type="protein sequence ID" value="PSR83659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1R6"/>
    <dbReference type="OrthoDB" id="3256283at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="269" mass="29091" checksum="D4D49CA548EBB7B6" modified="2018-06-20" version="1">MPPKRKQTGSSQAMATRSAKKAKTSAKAAPSNVTIAETATTTPPTTTVGEPTAAEPKPTAEPATEPKAKESSPQFTGKFDLYSTLLPFLKSEYLPQGATEPQFETLYKKILFYQAKPDFSMRINIDEAKTGRFTCPVICNPMSDEELEPIYIENGQTKQVAFSEMEAAHESTIGTGLGYTAKLMLGDSDGCGCGMVSGGKGTFKMRKVWEGEDEGKGELFEGYWTFKATYGPTLRRKGFGSGNSSSGVFWAVRARKNADGKEIGIDVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Y0</accession>
    <name>A0A2R6P1Y0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000562">
        <property type="protein sequence ID" value="PSR83329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Y0"/>
    <dbReference type="STRING" id="98765.A0A2R6P1Y0"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR83329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="227" mass="25954" checksum="6EB7D97AC6D4DBAA" modified="2018-06-20" version="1">MNEAAMGKAVRDSGVKREEVLSSLAASKIWYPDYGYESTLLCVDDSLEKIGLEYIDLYLIHSPETGKQSRLDTWRALIEQRNRGKLRTIGVSNFNVKHIEEIREACLELPAVNQMEIHPYCQNRPIVEYCKKNGIVLQAYCPLIRGQFDNPLFVELADKYKKTIAQVLVRWSLQHGFSPLPKSSRAHRIKENADVHDFEISDEDIARLDALDKGDDGALEWNPIHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P258</accession>
    <name>A0A2R6P258_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000557">
        <property type="protein sequence ID" value="PSR83540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P258"/>
    <dbReference type="STRING" id="98765.A0A2R6P258"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="156" mass="15605" checksum="B862086B099CA998" modified="2018-06-20" version="1">MSASQFCLRACKDAPQAPALCQHIYDEMGCAWNMPANYDSGTFERCQGDSGEPMGVYGTSTFHQGDPSTPSAHSAPSSSVCTTVSSIGNLAASATSGSSAPTSSGSSGSRTGTGGSGTPSATSSTQSNSAPRSPPLGWGRGVLFVLGMLVGGLLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC15</accession>
    <name>A0A2R6PC15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC15"/>
    <dbReference type="STRING" id="98765.A0A2R6PC15"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="6">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR88749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="153" mass="16843" checksum="A5700DB54D8BD938" modified="2018-06-20" version="1">MASNINSTIDSALQLEGPLVPADHGAAHVHNHRTPPLLPWPDIGHMAKWSVSSFKFGFGPECLRDDDPDTFWHSDGPQPHFITIEFPRKVAIQKLSVHLSFTLDDSYTPANIAVRAGTGPMDLQDIRAVSLEKPDGWYTFDVSAEPNEEGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNG3</accession>
    <name>A0A2R6PNG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNG3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="15495" checksum="BBDE179B8A718B40" modified="2018-06-20" version="1">MVYYTRHGVETVVDNAGGNRAVVNFCGRSLYWASIPSAIAQKRERIFSSVPVDHNTSLSFLSASHYASSTYCAFEISQKSSKAKAQLIELLKPETQLTNGKSSTTTKTSLWYTQASTTLAEGKETIKEATPLVTSITYPGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVK8</accession>
    <name>A0A2R6PVK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v4299</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVK8"/>
    <dbReference type="STRING" id="98765.A0A2R6PVK8"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="881"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="983"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR97592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1069" mass="115508" checksum="C3052F98D7D39448" modified="2018-06-20" version="1">MSTAAEHTLETKGEDKTQGPHRGRRRAVPTSAGQGTGSSEPVGDSSQKQNNRRRWKQRPPPQQVKPGPASGVGSKGAEGRSGVQPNLSGASGSSRPPHRLPLRSRDTDGAINPTSNNTTVGSESTESQKLKGPYRSGRRGAKFNSELTTDYKRPTTKSAGVDPAEKYRNPAPKKDDLTSTLIFDLSTPPYPDCLICFAAIHPAQPTWSCSPLIPISSATDDETTKDETRLRPETSRCCWTTFHLKCIRSWASKSVKDIVEAWKVRGENRPGEWRCPGCQSKRQVVPASYWCFCGSMPDPKPPRLATPHSCAGPCSRSRVCSHPCSLPCHPGPCPPCNVTTELPCYCEKQTLSFRCSNLAPSRAGVGANLSCGKPCGRRLACGNHPCENPCHDGPCAPCKVTEVAKCYCEKTERELGCGEGVAKTSSIIENGVKRDWTGRFECEDTCNRLFDCGVHRCLKRCHPPSINPAPCPRSPSLVQHCPCGKHPLESSSTPYFPRNSFLTRTSCTDPIPTCESTCLKPLEGCSHSCAAKCHIGPCPPCYIVTVRPCRCGSTTKDIRCYEDQTRARGQQEEIVCDRQCTALRACGKHQCNRVCCPLASLVGKGKGKKKATQLDLDGLGGYAGWHECDLVCGKMLSCGNHDCEERDHRGTCPPCLRSSFEEMICCCGHTILEPPLPCGTQISCRYPCARPPLPCGHPKIPHACHEDPIPCPPCPVLTEKVCACGKKTVGNIRCSQERVSCGTTCGKLLACGFHHCEKLCHGDACGSCHAVCGKSRKLCLPLNHPCTLPCHAPASCSETEPCRALVTVTCPCGRIRQEVPCGRSTMNPAGREGSLRLKCSDDCLMAKRNARLAEALGISSESRSAPVTYNQDLVNFAKADMKFCGLVEKTFADFISSEKKSQILPHMPESRRKFVHDLATIYRLDTQMVDQEPHRSVQLIRRIDSRLPNPLLSASSFAASSSTSSLGKLADLRAPVSQMARPAMGPARLQASTPNLPGSRGWTSVVAGSTSSHPSPVPSPTPWPSSQLGRRSGAVTPSRSAQPTPIVAAVAGQPSQSPEDVPDNWEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYU4</accession>
    <name>A0A2R6PYU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v4250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PYU4"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18659">
        <property type="entry name" value="CD2_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="203"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="302"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="404"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="701"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="959"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1247"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1405"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1294"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1407"/>
            <end position="1418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR98930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1544" mass="175474" checksum="9A69A66C19891DD3" modified="2018-06-20" version="1">MSVNGLDDDMASDHSPINPLSASSDESSDNNMQVDSDVDVQKLPDVDADADGESEDDDDVNDTPIVPNVGASSSSYLAKRAVKDEEESGYEDEPEPEDDEEEDASYADEEYGTVKKKTPKKKRVPSKPRVPTRPSNSDSDSDYGARSKKKKKRPAPGDEIRVSSRGTKVPNYVDDVQGFEQFEEDEAEASGYVEADSSQKEEDEIEMVLGHSRDEEHKDDSEDDWSTNVRFHIKWKNFSHLHNTDEMYEFLKRFKGLKRVDNYIKAYKLYLERLNAPDLSREDYEALLLDKEREKEELETYKTVERIISQRENDLNQVEYFVKWNNMNYEHCTWELLDEIRPIAKEQIDAFRKREAEAKFPYKSVAYARNQRPTFKKINEDPDYIVATGGELKDFQLTGLNWLAYLWSKGENGILADEMGLGKTVQSVSFLSYLFHTQRQYGPFLVIVPLSTITAWQSQFATWAPDINVITYIGTAAARDVIRTYEFGPSNKKLKMNVLLTTYEITLRDAKELGDIKWQVLAVDEAHRLKNSESQLYEALSSFAAASKVLITGTPLQNNVKELLSLMHFLMPEKFLLTNEFDLNDVDHEEKIKELHKQLESLMLRRLKKDVLTSLPTKSERILRVEMSALQTHFYKNILTKNFQGLIKSANGNNNISLLNIAMELKKAANHPYLFDGAESRTENNEETLKGLVMSSGKMVLLDKLLVRLRSDNHRVLIFSQMVRMLDILSDYMNLRNYQHQRLDGMVASEQRKKSIAHFNAPGSPDFAFLLSTRAGGLGINLETADTVIIFDSDWNPQNDLQAMARAHRIGQKSHVSVYRFVSKDTMEEDVLERAKKKMVLEYAIINQMDTSQAHLSSKANATKDNTKPNDLSKDELHAVLKYGAQKIFDKDDTQQNQKLDEMDLDDILNRAEHHETMAADNEGTSLGGEGFLAQFANVSDVKNDMNWEDIIPLEERQRFEQEEEKRKAEELAAQEKETKDRKRSHAPVSYEGMDVEHPAPAPAPKKPKHPAPQRKTASQKAMELKERDVRVLIRSLQRWGDIRQRYDVIVTESKLQDKNRGMIIDTADDIIELCSRAVDENNAEKRARLAAGETLTNAQKSKAVLVSYRNVGNINAETVLSRHRDLQVLFKYLNELNDDVYNWQIPIENIRPTLNWSGRWGPQEDAMLLVGAYLYGFGNWEQMAKDSRLGLEGKFFLEEGKKGEDAASKPIPNAIHLVRRGDYLLSILREHDEKIRAIESTLQRKSSGGYKASLSPPPVASSSYNASVKRRAESEAVASVDEGSTRKRKRRPTPTFTDSSSSDECPSMDEAATKEELRPVKKQLKNLKLSGGDMPRDDKVAILKESLAAIGKRIEFVLEQKAKSGEDIVRWKRHLWTFVTLFWPKKVKAAKLEEIHAKMVMKESAPRAASSETTSAAKKPRLAGASSTNATARILVRCIGHTMISSARLITLVSIFNIHRHLAIYSNCTSANYLMNDTHIRLDLDGYKEGASKSPILFQVRLRSIVTTNTTVHQKKVKDLGYSTVRLQGDTAYSNVIALRELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ18</accession>
    <name>A0A2R6PZ18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v4177</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000421">
        <property type="protein sequence ID" value="PSR99318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ18"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ18"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR99318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="354" mass="40513" checksum="AD535FBC7516580A" modified="2018-06-20" version="1">MSHISGDNTPNLPLMYSERPDWADVVPLPQYEGVNPIAPIFYTPEYKDATDYFRGVVKTSEMSQRVLDLTETIIRMNPAHYSAWQYRYRTLRALEAPLDAELRLMDSLAIQFMKTYQVWHHRRLILTHLTAPTSSPTKVDPIEAATAELDFIARVLTVDTKNYHTWSYRQWILAHFDDAGLWLGELPYIDDLLDEDVRNNSAWHHRFFVVFGRGSRSGATPEEDAEVFRREIRYIKDKVSLAPNNPSAWNYLRGILDHTQIPFNTLTPFAELYAVARVPASGGAEEVIDLENPGPSPDAVLPCVAAMDFLAEAKAREGGEGTANAIKIWKTLADKHDIMRKKYWEYRIKEVSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7E2</accession>
    <name>A0A2R6Q7E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000388">
        <property type="protein sequence ID" value="PSS03328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7E2"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7E2"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="5">
        <location>
            <begin position="16"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial chaperone BCS1-like ATPase lid" evidence="6">
        <location>
            <begin position="115"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS03328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="345" mass="37002" checksum="FE10EE5C17B16E23" modified="2018-06-20" version="1">MSDDTLSKLMGNVPSRCILLLEDLDAAFTRGVSRDESSTGAPTKSTAATAKEKEETKDDSASTLSLSGLLNSLDGVAAAEGRLLFATTNHIERLDPALSRPGRMDVWINFKNATKWQAEGIFQCFFPAKKLATTPSESDTAKEATGTIAPQSNLAAPKRKKGSQILHSLSEDEITVLAKRFADAIPNDEFSVASLQGYLLKNKTRPRECVEEAPAWVIQERETRAKLKKEKEEVNLTLYARGSYLRQSSQREAKEKKEKEEKVAAETSEAAEARSKATDATQPASTGTTSESGAASDNLSTSTADAESVTDDSSSKSNAAEVAQTGGDEKWVAVESTATDATPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB99</accession>
    <name>A0A2R6QB99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v3886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB99"/>
    <dbReference type="STRING" id="98765.A0A2R6QB99"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="42"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS05397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="370" mass="40126" checksum="98A5714C3AE8BC9E" modified="2018-06-20" version="1">MATRSVFSRLAPTLRRTPASTSFAARRVVLARGYASESEHHMTVREALTAAMEEEMLRDENVFILGEEVARYNGAYKVTKGLLDKFGEKRVVDTPITEMGFAGLAVGAALAGLRPICEFMTWNFAMQAIDQIVNSAGKTYYMSGGNVPCPVVFRGPNGAAAGVGAQHSQDYAAWYGSVPGLKVISPWSAEDCKGLLKSAIRDPTPVVFLENEMMYGVTFPMSAEAMSDNFLLPIGKAKVEREGSDVTIVAHSKMVTHSLEAADELAKEGIKAEVINLRSIRPLDMETIKKSVKKTNRLMIVEGGFPAFGVGSEICANIVESEAFDYLDAPVERVTGADVPTPYATNLEALAFPDTPLIVKVAKRALYRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBB6</accession>
    <name>A0A2R6QBB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBB6"/>
    <dbReference type="STRING" id="98765.A0A2R6QBB6"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="71441" checksum="768FB322AAFC5286" modified="2018-06-20" version="1">MSDYDFRPGGSLKLKGGVAEGGVVKKKKKSKSKSKEAESGLATLTGGERLSELETVLRDEEAKAGSPSGSSRNSPAVVSSDRKTAAEKRFEETQRRRLAERVAKLATQTHKDRVNEFNNKLEALSEHHDIPKMDWIPQWSAHTVIPDIVAILICLVVQTSFEDALLAMEANPVMTQILARFVLNLRPQTRNLSSDVISSTLATLLQEFMKTNERTVFWNEGMRGNLSPFDDMDCDFWGAGWGIKLDILRQLVELQLCHSTEVKSIIDRAWGVIHNKHKKAETTPARPPPSDPNSQENLQLVPVGQDCERKRYWIVDDSPRVYTSTNPWKITATFQCVSSTLDEYVALFKKLKESAPPEPKAGSKRTKLEAGHAALVKMLEGRLPTIEAELARIQRARKKIAQRNMLIAQAEVRETRTRRQTTRPDYAYLNDPDEDDQDEYKYQEDEEEEDHLGDDDFQSDGPSTSRRVTTEGRRRSSRAKKPNGSVPRTMDEWGEWRGERRSARLGAPSDNQLDGPPPKRARTVESTASSVDVVSPIVPSGGNGIKLKMNGAAAIKPTETVVEAVAGKKKSKFWVYAVEPIQSSAGIGPTAPAELDQNGGTSAVDQYRNGATDIDRPWAEVRQNGTNGHGIEGSLSPTSSMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBH2</accession>
    <name>A0A2R6QBH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBH2"/>
    <dbReference type="STRING" id="98765.A0A2R6QBH2"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS05477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="168" mass="18480" checksum="A0C296B76F40E35F" modified="2018-06-20" version="1">MVRSLRLSQPLRPRRTLQSRATQSARFASSTSGSSSEVAQKKAQDALAAAQKYAGNAVEKGKQFLGPVGEKVANLLGAYRQPVTYNFSVARELLKQVYVAERLQPPSLSTIQTAYSTLWARVRNPAYLRELVRSGDITKVGVYALEAYGIFKIGEIVGRRSLVGYNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEV6</accession>
    <name>A0A2R6QEV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEV6"/>
    <dbReference type="STRING" id="98765.A0A2R6QEV6"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="536"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="669"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS06844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="739" mass="82836" checksum="45100FEB647FA5AE" modified="2018-06-20" version="1">MGHDDHISKHKRSQDKGDREHRKKRHKSDKDGHNSKRKKDDVNRAHIVDEDVSGDDMWIEKNIDMDGERPLATDIPTAHSLSLTSRATSLPTDPSLPPPVASETRVQRDDWMLEPTTTPPIRDIAQPKRTGIPEVEDSLTDGYGEPSHDVRSASGGVDFFSSLGTERRRKPPPKLEEPKISHRELNVGLREGKTLDEYAAPVPKTITPGGPGSQWRMMKLRRVYETAEEEGKLVEEVALDRFGSMEAFEDAKEERRILDEREGRRASRGGKGKGRESEFGEKRFMFTDIGASGASSRSSSFRRPDVGDSAPSTPSPADNRLSRGRFDSLRLPSQGGIGTPLGQSHTPVPSVMTPAHLVATKSRALSPSSLNKLQARVLRAKLMNTPNAEALEKEYESEVRRMNGETVEDGKETQVAMIPTLDARGRLYDVGQANDDQPLLPGNRKPKEKVETRDPKTGELLRINADDDKITLGEMLRQERFNAGSADQKNMDAEFARSIATDAGFVNDLDYMDDNAEKLGRKKMRSDAMKRQFAINDYKRTQKVLATCSFCYGEDDSSPKAPVIAMGTRAYLSCTQYEDLVDGHCLIAPIQHHLNMLEADDDVWDEVRNFMKCLMRMFADEDKGVVFYETVITLKHQKHTFIECVPLPWAQFEDIPGYFRESILMSETEWSQHKKLIDFSSRPGGFRRAMVPNLPYFMVQFDYKGENGYGHVIEGTSEAAGDDDGAMDEGEKGGGEFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM39</accession>
    <name>A0A2R6QM39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v3362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000324">
        <property type="protein sequence ID" value="PSS10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM39"/>
    <dbReference type="STRING" id="98765.A0A2R6QM39"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="44"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="542" mass="58991" checksum="99B05EAD0C307D6D" modified="2018-06-20" version="1">MSSEGKLEHQEKVSDNVVESYTDSEANVPVYTGSTLHRTMKNRHIAMISIGGVIGTGLFLGTAGSLATGGPVGLLLGYVVVGTICYSVMVSLGEMISYLPIPGGHITMAERFVDPAWSFTLGWNYWYNWTIILPAELSAAAVLIGFWNDSVNDAAWITIFLVIVIVINMLGARAYGEAEFVFASIKVFTITGLIILGIVLDLGGGPNHDRIGFRYWKNPGPFAQFGGIAGSKGRFLAWWNVMTQAAFSFIGTEIVAIAGGEAKNPRRNIPKAIKRVYVRILLFYIGGVTIIGLLVPYTEPDLNLKASNAAKSPFVIAIKTAGIKGLPSVINAALLTSAWSAASSDLYSSSRALYGLALNGNAPKIFTRVSSWGLPYIAVSTNAAFGLLAYMAVSNGAGRVFTWFANMTAVAGLMSWFGIAVTYIRFHKGMKAQGMDRNALPYKAPFQPFLAWYAAISCVVICFFSGFAVFINHEWDTATFVTNYLPFILFPILYVGARIWRRSGLIAPEDMDFKSGLAEVEAASYDEPPPRNWVEKVWGWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM89</accession>
    <name>A0A2R6QM89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM89"/>
    <dbReference type="OrthoDB" id="2505473at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="29032" checksum="C98F55F8500541A5" modified="2018-06-20" version="1">METNQESAQAGPSRGRGRGKSRGGLGKYLRARGRGRGRGRPAEFSRRLVLEDEEDVELEEEEAKELQQKYSRRQLGTNADRYVEPEPELDSEGEQIVEPEVDISTFLERQRLSPQPSTAPPPPDDDDDDDIDHTLAHLSPQARQDSKTRKGRVQQIEWDQSLEEMIRQKAAADAARELKARFKAKTEKERAKALSNKSPARPSGHGTQLLSAILRKEFINLHIAKSDKAYAEAPALPTDVVQPKGEKEGMEDFLDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXP2</accession>
    <name>A0A2R6QXP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000292">
        <property type="protein sequence ID" value="PSS17141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXP2"/>
    <dbReference type="STRING" id="98765.A0A2R6QXP2"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS17141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22764" checksum="A46E7AECEC9BE0D8" modified="2018-06-20" version="1">MSSSRSPSLAQPRPFKTSSLLDLTVVALRSGPPPFDKPAHHPPGILIEASPFFESMFSLPQIPDDRKRKERDDAKYVGDTPVISVSEDNETLEPLPRFCYPGHDPELDKGELLYAVLEAARKYDMEEIAEKVSTQFVKYAEKYPFRLFALASSRCWTEEVKMAAKASLLYPVQTKYLEELDKVTSFFASQIERAISGVCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R101</accession>
    <name>A0A2R6R101_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000285">
        <property type="protein sequence ID" value="PSS18912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R101"/>
    <dbReference type="STRING" id="98765.A0A2R6R101"/>
    <dbReference type="OrthoDB" id="2804258at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24791" checksum="EC9BE3D2E898E453" modified="2018-06-20" version="1">MAAEVDNQQYYHLEYLDFPEPPVQNSGSVTVTSLLSAVEKGERVDIPLPRHPRIGRKNYIFRYNPLHDLESLWWIAIYFLVNKEITCNNEEEPSSSDPDISWRATIEQRAHAEALFYHNQPRVNVMLAFGRDFEYIISTLSPSLQPIAFILDDVRKLLIGGYQRAERNPETIDHTAADGLHEYFITAFFEIAGDLADQSLVVHPFVDLPSTSMDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7C3</accession>
    <name>A0A2R6R7C3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7C3"/>
    <dbReference type="STRING" id="98765.A0A2R6R7C3"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS22671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14799" checksum="F8578D227A26EB38" modified="2018-06-20" version="1">MNQLYALSLAWVIYLTLLPYSVQGMVDMMSNMERVANTPIPRSYSIHLKQTVTLYLFALPFTLVKELGWGMIPVVTVVAFTLMGIEGIADEIEMPFERYCGDLKEEVEYIVERLPEGGEGMYGFDDGEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHR0</accession>
    <name>A0A2R6RHR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spermatogenesis-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000260">
        <property type="protein sequence ID" value="PSS29549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHR0"/>
    <dbReference type="STRING" id="98765.A0A2R6RHR0"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46778" checksum="3D5C6469AFFE0E4F" modified="2018-06-20" version="1">MATDIISYISRDLRSPEGGFYSAEDADSLPSNDSKVKKEGAFYTWTASQLDELLEDNSELFKFHLGVEGDGNCDPRHDIQGELKGQNILYTAHTLEKTAQKFGVALEKTREIIDNSLALLKEYRDKERPRPHLDDKILTSWNGLMISGLSKAVEILDENRDMSSTALKLAEDSASFIRENLYDERTGELRRSYRKGAGPVGQADDYAFLIQGLLDLYEASGKEQYATWAIRLQEKQDELFYDKEDGGYFASAPDEHILVRMKDAQDGAEPSAVSVTLHNLYRLAHFAEDRHAEYGANAESILRTNSQLLNHAPFALATMVGAAMSANKGYRQFILIGDPKSPQTREFIQKIRTKFIPNRVLIYLDPNNPPAELSKLNGTLNELIKRTETDAKPNIRICENFTCSAPINSVEELKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM09</accession>
    <name>A0A2R6RM09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM09"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="39607" checksum="7FC8BDB71E2B0177" modified="2018-06-20" version="1">MPPDLPLDIVPLILQHLCRKPLIKEWRPFHQAEDPFSPDDLPDEGQLWDEYDVSWKYDLFSFSLCSHAMRRVALPFIFERMDYRFMNIWHNYPVTLKIADEQDPSIISTPARPKGPESSVLQDLYEFMAITPHIAGVVKNLRLQYAAEPCYEDTPGQEREIKSYHIDIRDLGKLLDLFGCLRSLELLGVPIDVPQSYHILETRGRAIDRLSFNSSHECTYPPTISFQPYLAPLLLFDRIKKLVLDYSFEEDFYKQPDRPVYFPFPGESLVVMCSPGLVGPVLERLAETDASRTETHLKSLKVCELTHSNLRPLNKLLSRFGASLVELDLEWVYQYGCKLHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPP1</accession>
    <name>A0A2R6RPP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS31992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPP1"/>
    <dbReference type="STRING" id="98765.A0A2R6RPP1"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="231"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS31992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="288" mass="30824" checksum="686B473A1408F8C9" modified="2018-06-20" version="1">MVFNNLPASEKEAFFGLLDEYFASRPDVFPNLNTASNSNNPVAAKAAVSAIHNAFTKESPVPAWKRQNNDTSPQPSNETELPSSVGRVAAAAASFKFSSPGQGAGPPRPPARNLSSSFSSQPDNDEASSASLSPRIPGNAAKLVAQKKFGDVDLSSGKNMYLSIRHGTANKTAPSAAVAPPVPAAFPPKKNAFAPPPVRRVSSVSNQENEVRASPPAPPPPPRPRQEEPEEQGDWAEALYDYSSEDPGDLELQAGQRVLIVERTSDDWWTGEYEGRRGLVPAAYVKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPR2</accession>
    <name>A0A2R6RPR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPR2"/>
    <dbReference type="STRING" id="98765.A0A2R6RPR2"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="169" mass="19041" checksum="B3E5A884F423793E" modified="2018-06-20" version="1">MSRFFRRLPVDKPVVRNNYSFQVIGRADGADPFDPEELSWAKAMKGDEDVEDGKPGFLRSQGANEASMASLDSKTEPVDPALIRLRVERQTLRRLPRTGAIVFTIRVYMTPLEELVKEPDVPGRMASAIRSWPDDVARYKARPVFESMLGYLDACHAEQVEGETIVKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVG4</accession>
    <name>A0A2R6RVG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVG4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7548" checksum="7EBE75E2772813C5" modified="2018-06-20" version="1">MEDLSEGIATDDGPAVGLVHDIPDSDSLEELDVVEDKDVRVDVMEAERLRRMGTIVKGAARAVTVSLENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZZ7</accession>
    <name>A0A2R6RZZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000114">
        <property type="protein sequence ID" value="PSS35577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZZ7"/>
    <dbReference type="STRING" id="98765.A0A2R6RZZ7"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF26">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS35577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="66813" checksum="4444CDF1829F034F" modified="2018-06-20" version="1">MSPALKPTLPTLDKLGVAIPQDLDVEKVAKAWLESFSQFVSAKDTEGIISVLDAEAWWRDLFALTWDLRTFHGPEEISAFLENRLEETQFGGIKFIEATLDRPYPDLAWITVQFAFETGVAAGRSVTRLIPSKDGAWKAFVIATNLESLKDHPERVGALRNHLPNHGKWVDQRRKEQEFADHDPEVLIIGGGQSGLDVAARLKHLGTSHLIIEKQPRIGNQWRHRYEALCLHDPLADWLEFYAGALELNVWTSSTVTNATHNEETGKWAVTVKREDGSERVFQVDHVVFALGLGGGAPKVPDIPGKEEFQGQILHSTAHRSAKDHLGKKVVIVGACTSAHDIAADYADHGVDVTIFQRSSTYIMSTKEGMPRMMSPLFWEGGPPTETADRLDNSLPILFTKLLAQRKAATIHEADKELLEGLKSVGYRTNFGVDDSGFVFLALKRAGGYYLDVGACQKIIDGQIKIKNDSQIERFTRTGLKFENGSEIEADVVLFATGFDDYRGPIRKILGEEVGKSLTPIWGLNDEGELRTAWREVGVPNVWYMMGNLAWARFFSKHVALRTSASFVISKAHISPFNPTEIKAKQEGLFGTRYPAPTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3D7</accession>
    <name>A0A2R6S3D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3D7"/>
    <dbReference type="STRING" id="98765.A0A2R6S3D7"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6391" checksum="070240BE80FA20D5" modified="2018-06-20" version="1">MESPDPAERKWACVAVSNLIQNDPSTRRLLQGKNIVGALITRLSDSEEEVVVEAGGALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3L1</accession>
    <name>A0A2R6S3L1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3L1"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="208" mass="23350" checksum="EA28850217453404" modified="2018-06-20" version="1">MPFVDIVSADDYVSLWYWTNTPSNNVGTFDLQKPTIALLHPVGLDSSWMQAQTEDPRLYCEFNIIMFDTRITGKSECKFTGKHDLWVSAADLAHAFYHLKLPPAHIFAPDLSTLAALRFAALKREPDVEKKKWYKNGRLDDKMTFQKSGSSSPSTPPLPEEPVSAEAQQLARSRRTNVFNATAVDKQVLKGSMAQVVSSNSSVPRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3L3</accession>
    <name>A0A2R6S3L3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3L3"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="26064" checksum="53DF597A158C562A" modified="2018-06-20" version="1">MSWIMKPDGDGQSRVRQRPSKLSNLPAAANVASGPGTSSKGIPTPGSVPGSPWAEFPMKDNYPKVADPTDQEREVSTKQANRPFLAYAQYREKRKLEHEAWLKRKEERELKLARGEEVGPEEPDPNEDPEVGCLGLMKFIVISLVVIILAGKFFTGSFLWEQELPDLRHFIPGLEHWRKYFAESKKYPKVGRVLHEPIDPRSPIPEHCDPKKAKAASETPITKPVTHHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3U7</accession>
    <name>A0A2R6S3U7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3U7"/>
    <dbReference type="STRING" id="98765.A0A2R6S3U7"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="24569" checksum="AEC18FA3AEBBD271" modified="2018-06-20" version="1">MFSKVFCTLALVMGLTLQVQAHAIISPALGVTGTPVRNDVQRPSTASPCGSVNIAKTLDTTTPIVAAADGSFTTNITNFNAGKDGSRQVTATVDATGTGSKFVAATVTENGDLAPTDVGSQPLAVQLPAGATCTGGTSGNLCLVSFTTAGGFGNCVVVQQAGAAGAAAAANSTAGAAAVANSTTAAAASTSSAAACAVQQGDAAGAVAAGNATAAAKPKHAKGGKAKQQNARRAWGTRLARAARAAIDELELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4G7</accession>
    <name>A0A2R6S4G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4G7"/>
    <dbReference type="OrthoDB" id="5563033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="195" mass="21469" checksum="B885317E8966E145" modified="2018-06-20" version="1">MFMASCYWPPAPLDAPLSMPWSDNITTFGEALLSRLPNLPADMVPATIPIADRCWCDFSGGLFEPFNTTLWELKSVEKLAEELGQKIAVGRNVTEGSESFEAGSTTSSPSAPTESPISTKWSDMFDAVWPFSTMPQSNSSASDLSPEQAIGTQTSPEDKRSRISTPSQNAESLLRREYDLRPYGFDMVVDLGWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5C5</accession>
    <name>A0A2R6S5C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5C5"/>
    <dbReference type="STRING" id="98765.A0A2R6S5C5"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="556" mass="59035" checksum="E4DCB0B44AD4046F" modified="2018-06-20" version="1">MGNSSSSGRGHHDDTVDFGYLTPQGIYTGQRDWNQAIVTQFIIDRKLAPFYRPLEDYDESWDDDQILAAMKEIQQPEPTEGESSIARPESVHSGPSRTHHKRPSAAIKEQIPPTWSDASRATLSAEADPNAAMKKRRKSFGADNPDVVSVDQIRPDWEAKLAAIRAAVARRANRRIVMRQVGDRLVPVGITSGRIHALPTEDAQENEGGGVERGSRRSRRRTQNNELNQYLGSMGLGGQDLEEATLRLSLIDYQDQQNRQREEEEKKKKEGDGTQIAASENEGAGASSSTSNSRPTPIIAPTVVTPSAGSSTVTTPVSSEGTMPGAFTVSRSSISLSRNSGELSPETSADGNRWRQRSPSPLGAIGAAMRSATSTASALASPPLESRVSNGNETIATSGSSSQGPLPSLPPANEPSASKGTATNFEDIHPIVVRTELDPTVPTPTTGSSSANLNDHIVEPGDENGAGSPSSDHTAIPSPHALDTSLSSDPRPISERTTSFASSLVTDTTQNPATYDYLPSSPSSSTSSLSQAPLLDGSTSIPYPPTTPSGESPIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5F8</accession>
    <name>A0A2R6S5F8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5F8"/>
    <dbReference type="STRING" id="98765.A0A2R6S5F8"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42385" checksum="00D70DBE96260955" modified="2018-06-20" version="1">MHILPLKGKWLVAAITACCCQGFLLLGYDQGVMSGIIGADNQFGTDFGNPDPTAQGNIVLVLPDSPRWLIAHGHEDEGTRVIAQLENADSLDDPRVLGKKKDIEVSLAQESAGGPFRYKELFEGGQIGNFRRICLCITVNIMQQFTGANMINYLAPIVYQDTMGLSRDLSLILGGATACTYMVASLIPLWTIDRFGRRPLLMISAAGLSTCFIITSILLSTGSKGAAFGATAMVFIFQIFLGIGFLPIPWLYPAEITTTRIRARGSAISSFFNWMCVFAVVKITPIGAFDHVHCPANAEHNPSAHSAINNIGWRIFIPFAIFNACWVPLVYLFFPETKGLELEDIDHIFDKGGFTGGVWYSPGGRTVGRHRVIQDVDVREDTMEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5I1</accession>
    <name>A0A2R6S5I1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v563</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5I1"/>
    <dbReference type="STRING" id="98765.A0A2R6S5I1"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000576">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="13 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="8"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSS37547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="388" mass="42836" checksum="F06F3E3C47552E9E" modified="2018-06-20" version="1" fragment="single">MATSISHELSIFIPLVGHVDHGKTTLTAAITKVLSERGGAKFTDYAEIDKAPEEKARGITINSSHVEYETDNRHYGHIDCPGHADYIKNMITGAAQMDGGIIVVSATDGQMPQTREHLLLARQIGVKKLVVFINKVDVITDPEMLELVDMEMRDLLTTYNFDGENTPVIMGSALSALEGKNPEIGVDKINELVKACDEWLDLPPRDLEKPFILSIEDVFTVPGRGTVVVGRAERGVCRKGDEVEILGYGTKLKTTLTGIEMFHKELERAEAGDNMGALLRGIKKEQIRRGQVIIAPGSMKSVKKFQAQLYILTKDEGGRYTPFMQHYRPQLFLRTADITIALSWPEGTADADDKMVMPGDNVEMVCSPVHDVALEPGMRFTLREGGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5R5</accession>
    <name>A0A2R6S5R5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methionine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5R5"/>
    <dbReference type="STRING" id="98765.A0A2R6S5R5"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12896" checksum="16EEB8DDFC313472" modified="2018-06-20" version="1">MVPTAASTVLRLDPPFRAEHVGSLLRPPQLLERRAQFDAKQCTAEELKAEEDAAIAAAVKFQQEVGIQSITDGEMRRGFFYEGMFEKLEGMENIVRPIETFSVGAARSVIISELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5T9</accession>
    <name>A0A2R6S5T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobalamin-independent methionine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5T9"/>
    <dbReference type="STRING" id="98765.A0A2R6S5T9"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16776" checksum="9D7CC49380F52AC6" modified="2018-06-20" version="1">MYFTDLVQAYVEELKELYYLGCRNIQFDDPTFAFFCADSTIEGMEEAGVDSEKLFDTYIKVYNDILKNRPAELTIGIHTCRGNYKGMHYCEGGYDRVAKKLFNKLNVDCYYVRSHTYDAYPGWFTEMTPRSWSMTTIGLVVSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5V0</accession>
    <name>A0A2R6S5V0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5V0"/>
    <dbReference type="STRING" id="98765.A0A2R6S5V0"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="363"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="405" mass="46040" checksum="1A5E4A5A273C4F85" modified="2018-06-20" version="1">MPRRPRPNSRQKSRNTAISRIPEKLKAATQPPNLVKRSRETSTSNHSGDIEPEDRSENEESDADDDSSSDPEEDDVDADAPRVVQWVDDEELNGDSEGDESESDQTDDEEDTRPGPSNLKSLQNDLSSISLGALRQAQKALARGKARDDSDSDSEKGDEEDGYSEGEEESGPEETPTSIDHKGKEKERERKDIATRKNKHAPQEVTSKRPVSRKRPAIEEKKLVPRDPRFLHITGEFSADKFRSQYGFLSDMHEEEMKTLKDNLKRARKMLASSPAHLREEREFEVQRLERALKRAESTVNRDKRERVEQSALSKVRQEEREKQKQGKGAWYMKDADKKELFVRAKFDALASSGGRTAVKRAIEKKQLKVNQKEKKRRPFAPGQGAKRPSSSQDGPRQSKRQRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S639</accession>
    <name>A0A2R6S639_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S639"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6169" checksum="61C899CFF52AFFE4" modified="2018-06-20" version="1">MGSLCSKAGTHTGGGHALGTQQAANERPNPRIAAAQAAEQRLKAVRMTTAQFHIHISAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S695</accession>
    <name>A0A2R6S695_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S695"/>
    <dbReference type="STRING" id="98765.A0A2R6S695"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF72">
        <property type="entry name" value="CAMK PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="250"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="649" mass="72037" checksum="78B6FAA44979F238" modified="2018-06-20" version="1">MQNTHGVQSPPFGYLSPPIDVNDTSSDDGDTLQTPLTEHDEQHQPYAVFHQHHFSHDLFRSDGHPERADSFNHHTTTRGEGSSFPSFPNLLTPPAREKLDVPRGHSQLDSYFPPFSPSYALDLANASLEFNLFSNAFAPPFHSSHVLSHDAQPFTPSRETFDFLAEAFSPPGPSQSDTSDFSLGPLPSMSISTDTIDDLDVHRGTPPSLLLTPDHHSHLPAEDPFMVKGRVYSPRFPAEHLLNHFFVRSYQLGDELGAGGYGFVMTATHRTGGYEVAVKFIIKDKVPDHAWWEDDMLGRVPTEVMVMSLISHDNIVKCLDIFEDDRYFYLVQELHGTPWVSKKKGVKQITAPGKLVVPCSSGSSTPLLTPSPSTESNGSLPPTPPQVYTDVNDDNITDSHLSAILECLPQASSSPSLSLVGTLEPNTERTAQCQGLLQPPPPRPNFSRRPSYDLFECIEQSKHKRLSENCARYIFAQVVEAVHYLDSQGITHCDIKDENLVVDSDFKVKLIDFGSAVVADPFISRPYYTLFFGTTAYASSEILRKQPYQAAPAEIWTLGVLLSYLLTGHSPFPSEQDAIDGRLVMRERGGAGRLSRAALALMGRCLERDPERRADIAEVRGHRWLQGALDRENLQISSVSFPSMDSKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6B5</accession>
    <name>A0A2R6S6B5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6B5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="202" mass="22385" checksum="490A6CE1B27C2574" modified="2018-06-20" version="1">MALYRAGEYLTHLSVVVEIDGNAPRNSAEKIIGDALSLLSSLSRLSHLILKLSWRDENSNYLNEPFRTFREMNREELATKILGAAPVINHIVLAIPGQFGQTKYAYVYEVVKNDSDGGERTLVELIGEAAWKPLRSNPRMCRLSACSLMFLCGVFTDYRALHTYHTHGLLTTRNGYKTTSNGNCSAVGESRIPGRSCACNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6E1</accession>
    <name>A0A2R6S6E1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6E1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="217" mass="24142" checksum="760FC4B13A4E4666" modified="2018-06-20" version="1">MAESPDGSESVGESGDDGQLTIRIPNPKMYMARQSQWKGRRGKPRVLPTCNHCAWANGRECKYTPLPTPAHRGIPRCDRCRLKNLKCDRNLPVCNHCADEEDTECNYTPKKRHKVPSDHAATRDRPVAPYAAKTASFLVTDMPAGQGDTPSGDNGSTSGPSGSHVYEREIRTEPQIRQYMPPHSPALHDGDEMEHSPDMEFKQSGDGNFTWVCHLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S759</accession>
    <name>A0A2R6S759_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v45</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S759"/>
    <dbReference type="STRING" id="98765.A0A2R6S759"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS38138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="462" mass="49917" checksum="E820BBABBF312C0F" modified="2018-06-20" version="1">MLQYRLYNGDALPSGLEGFVKAGANIGSVIGQFTFGFAADYFGRKAVYGKELMLIIFATIMSISDPTGDLSPNGALVWLGVWRMVLGVGVGGDYPMSASITTERAHLRRRGTLLAYIFSNQGWGSLVGALATMIVLLCYKSTMEGGDTGKVDGVWRIVIGLSLIPAFGTLYQRLTLPESKRFKETQKLGAEEDGVEDLKSKADADVASADSSTNKSLNEKKQSQSVAQETPATPRSGSAKPALQTKKAHFHEFFAYFSEWRHLKILMGTCICWFLLDIAFYGINLNQNVVLQQIGFDGKSGSPWTRLFKIATGNLIITALGFVPGYYATVLTIEKLGRKWIQVQGFLLAALFLAILAGKFHTLSTVSFIVCFALLQCYPAEVFPTKFRAAAHGMSAASGKAGAIISALAFNSLSAKIGTPAILWIFFGCCIAGAGFTFLLPEVRGRDPDVIYAQELAAAGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDI8</accession>
    <name>A0A2R6NDI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001355">
        <property type="protein sequence ID" value="PSR70405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDI8"/>
    <dbReference type="OrthoDB" id="2792479at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="179" mass="19266" checksum="C1DCA053CA063EA6" modified="2018-06-20" version="1">MSSTPGLNADSAIIPLAVLCFGLVAGGIAAVIITRKISRTRVIMQIRQAQELAEGVGEKPLLVEVCIGPPPEDRSRGPVSYPLPWSDFLPMSVNLSSTLSSPHPHHTIEHRPGYQLHPLVDGNVMELTVGIAMPTSSLNTHSPRYTKEPPLETLEYCIGTKDAVVCTVLGTKQRLLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEU3</accession>
    <name>A0A2R6NEU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI transamidase component PIG-T</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001304">
        <property type="protein sequence ID" value="PSR70895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEU3"/>
    <dbReference type="STRING" id="98765.A0A2R6NEU3"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13520" checksum="01732ECF31F3CDD8" modified="2018-06-20" version="1">MDVTKPFLRYTEHPPDAQRGWNLPPAVVVPLAWDENFTNHSFVSIGTTGLTSQRLPHARIYTPILLVDLATPDFSMPYNVIIMSCTLIALIFGSVFNLLTRKFVIVSVLPKIPNVREKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFM9</accession>
    <name>A0A2R6NFM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001291">
        <property type="protein sequence ID" value="PSR71197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFM9"/>
    <dbReference type="STRING" id="98765.A0A2R6NFM9"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="160" mass="17114" checksum="FD7C8F020F03EC90" modified="2018-06-20" version="1">MSQIQEEISAQLKYILKATAYIFSSVFDEYEYQPEAPPPQPSADSSSSANPPPATDVAFEIPLNTLIECLNIFGTAGTSNSNLNPSTKTRQWRKVGEESDGDDQDELRGSGASRRRDGRGGGRGGGASGNGRIDQFFGAEKGTAMRVSYAGPGYPLTLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFV5</accession>
    <name>A0A2R6NFV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Breast carcinoma amplified sequence 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NFV5"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24970" checksum="CCD6A6988B45532A" modified="2018-06-20" version="1">MSGGDIETAQGPSMIFDSLPYYDNDLERDPGLKDRAERLIARELKPQQGLHPRVPPPISLFTNNPLLQAELARIESHKPLPQLDTSRYQLPGPTSSPATEQDWQAALNNAHAQLEHQRLRHTNLALLQNYGSNVWRIHNYQMEATAKYLDKTLEDLKQLTIEVNRDRKNFQTRVGTQLTTLETRWTELISSVLQIEMANVALEAEIDRLGKREVELASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGN5</accession>
    <name>A0A2R6NGN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGN5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="116" mass="13362" checksum="D7DB545E9CFE30DE" modified="2018-06-20" version="1" fragment="single">IERAITGFRTGQLAKQHKRFGYLYWGKTSIRYLHNTETRIRYRTWRIIIIRSRRSIAPAAAHAEFTNITSKLPDADDDDYVLDDYTDDEWEGEDGGEMGTTMIVDTEAGEERTADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGS5</accession>
    <name>A0A2R6NGS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001263">
        <property type="protein sequence ID" value="PSR71584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGS5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="6008" checksum="E3919C543D7FDAE8" modified="2018-06-20" version="1">MHTTPTISFAQSRVIVEAYQCRLGIFAQLVLLGSLGDVFTWFKECRHVELVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH23</accession>
    <name>A0A2R6NH23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001254">
        <property type="protein sequence ID" value="PSR71685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH23"/>
    <dbReference type="OrthoDB" id="2692137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="651" mass="73961" checksum="93E9F468C23F6A31" modified="2018-06-20" version="1" fragment="single">PPVNYLDGLVGATSPEKRYIITSPNVEFVPLPIWGKIELRMRADGRFGIHDPINCPQTFLYKHGHLAAILREPDNVKDPIACMWQTPRPCDFVPLDGMSSAAFGTLAPTTLQPISACIRKLSDDVRRYLKHHPETQYLPALLLAMQNCYARLEFPSTFRDLIRQVASVQRTWLECRALWDWVGTFIPLLDNHSGAKPAPVKVNRMGAFTMDPAVVQNLMAIGLPVWFIRRTDQLPGSTVIKKIVPAAHAAYTTAIEMGFGPYPGQAVYSGYAGTEQHYLALWRTAFRMLDIEHTLIVDAFIEEEERTAGRPAASSSSLPSSTPGAVRAKHSHVNNCPYERPPATKSSATKAPKIRGMNKFLVIQHDRIPQAVNVWATALAKVNRAKTPANNWGYWLPEPHMLVGPDGINRARNYLRNWFWVREGWLYMLANRATRFDPLPSKLWRDWLQHEPEKVKEYKADNARLRRKTYVLNLFTANLPNELSQEEPGKDTIFWNNQRVESPPSVAIYREIAWEVLEIAFRVELLELDRYLVPIDTNDMVGAEFFRQEKIAKVFSDGQLMRPVRLPTSSRGLAATHIEDRRDSIQALHQLVLRWPEVPRAIVDSNTVPNMNTAALQSLEIALATYYVQKFYEVSGRAATIPYHFPTILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHK7</accession>
    <name>A0A2R6NHK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001282">
        <property type="protein sequence ID" value="PSR71472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHK7"/>
    <dbReference type="STRING" id="98765.A0A2R6NHK7"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16090" checksum="18E83CF3629D8256" modified="2018-06-20" version="1">MPPKKVKVVKEENAVSLGPQVSEGELVFGVAHIFASFNDTFVHVTDLSGKETISRVTGGMKVKADRDESSPYAAMLAAQDVATRCREVGITALHVKLRATGGTGTKTPGPGAQSALRALARAGMRIGRIEDVTPVPTDSTRRKENSFSNPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHS5</accession>
    <name>A0A2R6NHS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHS5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="15404" checksum="A31DE18FB946E4F6" modified="2018-06-20" version="1">MTTDRPNSKGHKDLRTLSPLRLYNISKAESEAIKNIGRAKQESPDATALLVVWDGVGTLVVDIDDVVGLDIVAGIDRERGALKDDEDDVACNEADVEETELGKPVVWPDAELVVDELLGLDDADEDDPGLKSEEIGLRVILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHV8</accession>
    <name>A0A2R6NHV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHV8"/>
    <dbReference type="STRING" id="98765.A0A2R6NHV8"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="9668" checksum="3AB9C56E36EC2614" modified="2018-06-20" version="1">MSVLPLAKRSMRIIALPLTTASRTPDSAASGHLTYVHFVTPPPKEEEGTNWLKWTTGKAADLWAGFGKAEDGTWKVRTHFEVVNCSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHZ9</accession>
    <name>A0A2R6NHZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHZ9"/>
    <dbReference type="STRING" id="98765.A0A2R6NHZ9"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50570" checksum="098654F26424BC96" modified="2018-06-20" version="1">MWMPVEDEDQMGRDFFGFLANLVKVFPSLKTRPLHITGESYSGTYIPYITKTYFGLEDPPVKLVKIAIGDGTLGSDWEFEVLPTLTVIETYPQLIGYDPDVYKYFREQSHLCGFDINLTYPQHGHFPTLNPQEPNFGDDAAKRASKKKSFNEAFKLDSHFTRNNLKVRSLEPGSERLAKRDQWKRDIIGRPNGTIDPYYGCDLYDEMIDYAVNFSLPWKGNDEENGFDVYQIPDALDPEAPMDASIFLNDNRTRAAIHAPTSKNWAQGINYPFNNSFRGDPSVEPMAFLTELATNASHRGVGNTTFGGIQGFTRKPSTPWYGDDGVFAGIVHQERNWTYILVKGAGHLVPQQQPERAFVFLREFVFGNNETGLVTSVKGHTTVIGGEDPQLANTVLTGQSGIYYGSGTTQYTYTYPTATIAAWETFIAFATDTENGKVAASATAAQLVARTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ81</accession>
    <name>A0A2R6NJ81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001183">
        <property type="protein sequence ID" value="PSR72430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NJ81"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1338" mass="153023" checksum="05271B98F8B8565F" modified="2018-06-20" version="1">MTKICCHCQGSFSSLNGLKSHRKGCKARTTSILRSVQQRTQAKAKIRRREKQDITGDCQELRDELNEAPELQHMEPITVPVDAYMRPPTPIPEIPQHTLPPTRSGRIRKAPRHHKDFLPSTTTGVLHTHISRLLPPPPPPADAPIDVPSLACNIETPMDSEILPTGMQNEATVFETEPNDFGVYRRYHRKPCQDISEEGTDDSLCDTPTIATTSPFNPSSALDSFGRAVVNGLAKAPDWFTPFLNSTVFRLMHWAYTGSNQKSTGEIERLVHDVLLSPDFDREHLEGFRMGREERRLDEHATSTNANFNIDDGWHEASINIPLPKERTRHDSEEQAPHLEVKGVWHRKLLDVIITAYREKSVRQLVFTPYQFLFQEADESPERVYTEGYTCDALLEEDANIQAQPRHVDDNQDVEYSMVPLMLWSDSTHLANFGTASLWPIYLYFGNLSKYLRCKPSHFAAHHLAYIPSLPDTIQDVYQNIYGLPATKNVLRICKTQIMHAVWLLLMDEQFMEAYVHGILVDCGDNIRRRLFPRFFTYSADYPERILLACIRFLGRCPCPNCLVLKSRVPDMGTKYDRKRQSENGRKDTTFVQMLIAKARKLIFQFGKSITSKAVECKIQPTSLLPTRSAFSIRLASLGFNHYSLYVYDLLHEFELGVWKANFTHILRVLYAEGGDRVQALNRRFRQVPTFGRYTIRRFSNNVSGMKKLAARDFEDILQCILPCIEGLLPSPLEKIVLDLLWDLAVWHALAKLRLHTDTSLSILDQATTNVGTSVRRFARACANIDTRELPREEAARGRREVAKGKVVAGKKQKKLNLQTFKWHDMGHVVSMIRKCGTTDGYSTQVGECEHKRVKKMYARTNKREHEGQIATKGHREGLLVKIKEKEKDLKPCDSQQSMHPGDVPPPIHGLPSQPKKKRGRPKKNSIALGPEDDDRLPQTSFHAHHHISDSQRFAVDIPKFLSEYCKDPGVKGFLPLLKDHLLSRLTRREFDGDEHVFSDEERDALRIVDNRIYRHKVIRINYTTYDMRRDQDSVNPRTHADIMVLSPEEDIEGEDVDLGHPYWYARVVGIFHAKVRYLGPGSTSSDIQKVEFLWVRWFGRDLSALGGFGKRRLHRIGFADSEQPGAFGFLDPGIVLRAVHLIPAFHYGRTTAKLGPSILRQPHDLDEDWDLYYVNIFVDRDMFMRFLGGGIGHKATRLIVRIADTLRHFFKKKALVVEDPSEIDDDGLDIDALMDVDLAVVDDGADSGLDEDQEHGEVEGHDEGEDEEGGDKDEEEEEEEEEDEDEDEDEDKEDDEDEDKEDDEDEDEEDDEEEEDLGPEDENREPDEGYDCGYAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ89</accession>
    <name>A0A2R6NJ89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001188">
        <property type="protein sequence ID" value="PSR72424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ89"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13843" checksum="7BD9789C70F1A086" modified="2018-06-20" version="1">MNDPTMWDLLMEETIRTPFPYTAQDRRFYENAPYTAPPFRARQAKDGFNWGEEVDRERPWEQARGPARGSQNTRQNTVRIRNGSGNGGTHQMVLDRHFRTHEDTRSIPSGSNSMCSGIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJG3</accession>
    <name>A0A2R6NJG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001168">
        <property type="protein sequence ID" value="PSR72494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJG3"/>
    <dbReference type="STRING" id="98765.A0A2R6NJG3"/>
    <dbReference type="OrthoDB" id="2797670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF14">
        <property type="entry name" value="RETROTRANSPOSON COPIA-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="22523" checksum="CC7F7CFC0AB560DD" modified="2018-06-20" version="1" fragment="single">ISSVGLFVDQSQVAHIRDCTSGPAAWKALAAIYERNDCATRISLKRELYTFVHDTSLPIRDYVTGITTVAGKLKAIGVDIPDEDVTDILIYALAPEYNAVATSLMQSADDTLSIASITGTLVDAEAKMSQNSSGPSVAAYAAKTRPSVSTTTPSSTSAPRPPPTCYRCGEVGHVARSCPAPAPVSSPNSDNTLAVNRAWLPRSDDDEYLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJI4</accession>
    <name>A0A2R6NJI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001160">
        <property type="protein sequence ID" value="PSR72513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJI4"/>
    <dbReference type="OrthoDB" id="3060478at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="22374" checksum="74DEA40016DDCAD0" modified="2018-06-20" version="1">MDCDTPFDRGEGIMFFPGRTVFSSNGRDGTILAGHRKYNPSTQNIKSSWVINKELTHNFGKIWELFYSSEGGVYYAGTFRCTVSPRQMSRASFLDLSETTRQQLFPYIFNCPLQAVPLDEHLNVVRMYQQGKVSVSCIRVRRIGFNWTLIDALALNAAKKPVPVPIPIPSNSNPDSRKRKYGADSSDSQVAAPSKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKC3</accession>
    <name>A0A2R6NKC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PHLCEN_2v11332</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NKC3"/>
    <dbReference type="OrthoDB" id="1750432at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0229">DNA integration</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <keyword evidence="18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="21">
        <location>
            <begin position="1291"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="1965"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="399"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="618"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="2553"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="2557"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="2569"/>
            <end position="2586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PSR72835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2662" mass="297366" checksum="EF2A3D999D2668D2" modified="2018-06-20" version="1">MTRGTITTRPLTRYHLRSRANSTPAQPVAIPGTFLAPSIAQTEVSSSEVGHTPTSPLTSLSRQSGASEVLRPVLYSQVASSIPSVESAAPEVSVTSSTNGISHIFSALSLRDKTQGRSASVEEVADEGEPSRNEYVTAETGTWTEVRYGKRARSPAYQVSNEGSPQDFECTGEQLDELALSLGQSARPLSNRRPPSRGEGTSQGKGKTVDPRNWGAANIPSNELDPELQRKALDFYTKYHSAGTVPPSQGLSDDDHNKDTHSEVLVHWNSSANDSINTVAIESPKGELTKAPKFLTREEQLLHEIYLLKLELSQANPATISHPIEDMVPKVRSVSTTHPVTSLSAVPSRKDLYPTQVAGSTTTALQAQEPDLNGEKLRPVNQVEPSSCLGRIFGKIAKLSPEIPPSGGPPSSSENSSSSDEEGSNSLPTTARRVRSRKTKKGHRLPTLKPREPDAYHGRADVHEFHKFMDECSNYVQGYSLAEERYVATISSFLKGKAYKYYTMMVSKDAAEWSLERFFRGLFDFCFPVDFRTSMREQLQHSVQGARQSVQEFVCELEELFMMVGFVSPRDRVLHLWNGLQGELRDEMFRFGLSPEISTWAEVVAAAVRFELAEASRRRRSQAGGGHHHPGGYNGGGPPGPKPPRGGRGGSGGYRSIGVTSFQRPPPNLRPSQGHPGHLSSMAGRPRVNQAPTNGSPHPRRDGNNPRPRQAALSEKEKADLRAAGKCFICKEAGHLARNCPLATNTRSDRRGQPPGVSTFSMAIDFDKIDSLRLQADASDLEAIRCNLMSLDDAGDEEGPSGDDTESADAPILEINWARAHDRPDLELPMTRREGRPYIRLGDPYSEHASNVLTRHMPYCCGRALGDECYDIDPLVVYQISETHNVIMGRGLVPDLEVPRYLLDDAEFNLPQWYQARVAELLGHRSCGRRAIPGEELGDVLSLAAEAILLKYIPFPKAWVRYRDGQVDQRFYCHRSQDAPVVVVHDDYLFTRSEIPIECFANRSLDLPNLYATVIRRVLAEPVFSVDALNDELLELFGHNDPISTPIAGEFIELFTVHTSKTGTHQPIAAIQRNAASVKDFKRLIPDSIVVIVNINGQPARALIDSGSMADFLSTKIAHQLKLDIFELQKQLPVHLAVQGSRAKISCGAKAELHYQSIKEPRYFDIVNLLNYDLVLGTPFLFQHRVTIGFNPTSVVVGSVTALPIQGKQVRVLESRAADVLHEEMEKARVQLRAYAACIASNDASDTPLPPLREINHRIDLKDPAKIYHWRPSRCPEALRGLWTKKRDAYLQSGRWKMSNARNTCPMLLLTKPGTGIRDVPPRLRTVFDLRERNENTVKVTSPLPDMEGILRRIAKKPYRSSLDGKDAYECIRIEPDHVERSAVTTPDGNMVSLVLQQGDCNAVATYQTLMNHLFGQFIGVFMDVYLDDILVYSDTLREHFEHVRKVVDILQREKLYLNKDKLKFLQPELKVLGRIVDDGGIRMDPDKVDSVLHWKPPTNKQLLQAFLGSVGYLADDVGLVRIPMGVLTELVGPDRVFQWTHTHQRAFDEVKRLVHSHRIHHRVPLDYTAEAAPIWLVTDGSVSGIAGVVSQGADRRTAQVAAFFSAKLSTAQANYPVHEIEMLAGVESMRRHRDILLGCPFTWVTDHKGLTHLLRQKNLSARQARWIERISEFNFTVEYLPGLENILPDALSRMYSNDAPGTVRAASEYTIFDDDEDLPLRLASFAVTIPVLAGVEGKASQAPRRRSPRLIAPAETGRPETAKEFSKRIQRLVVHGPRVQRAEGAPAVRPVPVTTDPTEATVETASVRNEQVVDEPSTTNSEPTTNNTFIDLLKDQSNGYHIPDIVRGRYAEDPFFTTIVKDPKQFKNFDIREGLIILRERELERLCIPDITIDKRSVREILISHAHSLLAHLGSFKTAGLLREHVWWKTVGADVKKYCATCSTCKRSKPDNQKPYGLLNPLPVPGNPWEAIGIDFVGPLPVSEDRDGTYDSITVVIDLLTCMVHLVPSRTTYNARDIAELVFAEIYKHHGLPRAIISDRDVLFTSTFWTHLHKLLGVELRMSSAYHPESDGSTERANRTITQMLRQCIHPNQKDWVTRLPAIEFAVNLARSESTGYAPFFLNTGRMPRSLIWEHASDSEYPGVRVYAQKVKFAVMAAHDSVLAARVKQTRDANRRRRPTPFEQGDLAYVSTKNMSLPRGLARKFVPKYIGPYRITKDFCNNSYRLDLPADLKRRGIHDVFHSSLLRVHEPNDDRLFPGRLASQVAEMEDKDNEWVIDKFESHRGSGPSALFKAVWRSGDCTWVPHETVKHLHAFNEYLVALGVSNIQHLPEGGGAPPTDDPQVYLGCMVLDRATRYKRPPRFAQRDIGLLCQSSAFSPFSQRYHSPLQPLLSNPRHPRPHRPVPVPMPYRHPRVSYRNDGALVIGFEDCQYSFTVSELQTALFFDSQLRELRVRSSTTIQPGFYDTFARLWNDLAECKYKFAVFDPSKEAPTISGPVIPRLELLHAQHTRPVRANPNSSGVDITDDEQQQLVLIAVREKLRTDRMRQLGIAARQAKRDLRPEPRMKSSPAAAPRRVRSRAAVQRPPRDGHSEDAEYELDDNEELIEYDLDAPMAGLVTEGQGSGSGTYLEAIEADTVVEPVVTKVAYKKSDKAAGKVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKL6</accession>
    <name>A0A2R6NKL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v11222</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKL6"/>
    <dbReference type="STRING" id="98765.A0A2R6NKL6"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="489"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR72919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="675" mass="73640" checksum="E10DDB9301D20EDA" modified="2018-06-20" version="1">MAEPYPIPSNNPASQYTLLEKLGTGSFGTVYKAMHNETKQIVAIKQIDLEDSDDDISEIQQEIASLAQCDSEYVTRYYGSFVVAYKLWIVMEYLAGGSCLDLLKPGVFSEAHIAVICRELLLGLDYLHSEGTIHRDIKAANVLLSASGKVKLADFGVAAQLTSTLRHTFVGTPFWMAPEVIRQAGYDAKADIWSLGITAIELAKGEPPLAEYHPMRVLFLIPKAKPPVLEGAFSVAFKDFVSLCLTKDPKARPTTKELLQHRFIRTARKTSYLTELIERYQDYRTRQPGRGPQMYQATVRNSGAWDGTLRSDWNFDTIKTSSVMGSLRSMAKDFAPHGTIPDEDYYDGESVYDPSDSINSDGATKGSDVPSMGVLSNADAAHSTVIIRPIASTSEKDLPSLVADTGSDEAVGFATPSTPPSAGADAIEPPPAYTGSVRSSRRASYAARNNVTSGTVLVEADLGNGVDTIRPVKKVDTVRSLRLSEEYVGSLRRERSGSGSQAGSAPSSPVTSKVGSGHKRRPSEVMNAGRVMVDAVLLPTLERATRDDMDAREIEGLSMISRGFEELRDVNPELAYNVILDILSGINENHQVRQHVQTARGLFPHKRIIRKSEMTAKGLIVTEEEEISGLPSTSGSVPPPVAADDTTPRKSPIAELLYMRWLEGLKLKWPSILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKR0</accession>
    <name>A0A2R6NKR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v11575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKR0"/>
    <dbReference type="STRING" id="98765.A0A2R6NKR0"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="45"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR72582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="35976" checksum="383712099C06CBAE" modified="2018-06-20" version="1">MEKTLQSMQGAGVKVLRTWGFNAINGSELAGALQSGLTYYQVWNSSQWALNDGPQGLQRLDHVIETAAKYDIRGAELYINWIAGSGQTHDVFYTNPEIVSSYQSYVRTIVERYKNSPNIFAWELMNEARCAGDLLPSGPSCVAGSETLLKWYEQQSNFVRTLDPFHMITTGGEGHFFWQDPPEYWFDGTLVSDFNFNGQAGEDFDRNLGLSNIDFGTYDFPGSNFSVEEWGLGWIEDHARSASNAGKPVILEEFGLSGLVNKSSIYPTWVNRALDTNHAGIMPWQFGQLHLTEDGGNRIIKYTDALNHGASPNDGKYFEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL34</accession>
    <name>A0A2R6NL34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001116">
        <property type="protein sequence ID" value="PSR73063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL34"/>
    <dbReference type="STRING" id="98765.A0A2R6NL34"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="618" mass="68566" checksum="F3366CB01F1B07AE" modified="2018-06-20" version="1">MATTTLPDIIPPSDPARCRTLVLCFDGTGDQFDADNSNVIQLFTLLQKDDHTQQMVYYQAGIGTYTVPQIATPFMANLSKNVDAAIAWNLDAHVMDGYTFLMQNYQAGDKICIFGFSRGAYTARSLAGMVHKVGLLPSCNHQQVPFAYKMFTRTDETGWRQSVAFKKAFSVDVDIEFVGVWDTVCSVGLIPRRLPFVSSNTAIRYFRHAVSLDERRAKFKANLYNRPTDEESKLGTQPGDMPVTNTSITATATITTTDTYSTSASSTAAAANTLHKGSRIPGLTTLDEWVGKGKDGKTGSVKTKKTTLDVDIEVEEEEFDAEEGDRDRKKETDVLEVWFAGCHCDVGGGSVPNNTPHNLARIPLRWMIRQCFLAKTGIRFHTSLFPNVGLDPATLYPDVKPRPQEVYATAELVEDLQNAEAATYLMPTSFSVTKATAEVESPTPTANRVSSPPMHDRTDSGLTLVDGDVPASHTLTKTTTLRETALLTTSAGAFLTEEHQDLLDSLCPIYDELSLAKVWWILEIIPQLQRYQRPDDTWDEKYECNMGHGREIPRRKARVEADGVVEREKVYVHRSVKVRESAEGMVQMVGRCGEVLAKKGSYKPRATIPEDAEVIYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLP6</accession>
    <name>A0A2R6NLP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLP6"/>
    <dbReference type="STRING" id="98765.A0A2R6NLP6"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="649" mass="72324" checksum="A60EB381750C246C" modified="2018-06-20" version="1">MSTWKWPTSLDFTSLQAQLSALFLELSMGPGSLYSEIVDSPPDPKVYPEVDWDAEVRFGQELCMAERAFIGERRRAMRAPFANLIGVPESDIDERDLPIVAVAGSGGDHMLGSCWALGVLHSGVAGLFQPKDAAAHLKDRIQLSYFDRSTLDALVTPPTHKSGILRKAAGPGGAVSLVDVYGTLLGSRLFVPSDLSKLNPQDLSLHLMRRGIDRGQRPMPIFTAVQHATPPVAVQALRELQAKRITAVDEDRAVSLDQEKIRLADATRCLWYEFTPYEIGCDEIGAWIPSWSFGRQFRNGLSVERRPELGFTILAGVFGSAFCASLKHYFAEIQPTLEVLPSQLFRWLREIITENERDFGLIHPVLPDQVPNFLKGLDGQLRYGSPPDLADREYMSFMTLVQIPKTCGLHELKVVRTSFGGKHFDVDDDSRTELAAKRGLRTWPKGTGWPVAVQPQGDANAAINRNAPGASPTSDTAAQTATRKLAETQESELAGQTDKQDSGTSHDLPQESRGSSESEVFSRPPSIRPCEVWIGSSESNEEDSSRLDDLDEDALLMRDGIGVVYIPLASNERTLPGFDPFAISTWRREVTAEESQALLDVAQANFEDSREKIVRLLRAIWLRKKHTREQKEWQEHFIQFRKNLRHNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMI5</accession>
    <name>A0A2R6NMI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMI5"/>
    <dbReference type="OrthoDB" id="3240950at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="394" mass="45875" checksum="7F00552E6920A930" modified="2018-06-20" version="1">MPRLFPSLHRSREHAREDYTRYNEYGHYDPHPPQHTPAWRRVIPTKKTRESSRWPEEVVEYPESYNGHGDYRRRQPQAPDHPYGFHPAENFGRHSESTLAHTEDAYDTHYPHDDAIPIVQRESSLTRLQEAFADHETQPRPVTQVNLPPQGTPRHSPHDFPPPPPPELRNVYPSQQPVLVQNTRVDSVEADVRVRSRSHRAQEKRPDTGRRERAENFRRDPSIGARSLDEEDYPPCVVVVERGRNGKQDTYYVIPGGAPVIFEDDEGKELTRVGDFSGKYRPRRQRPVIIEDENGNEVGRLGFDDEASLDYPYRNRSDDSLHERGGGYGHSRRYRDEYDRHSGSSRSHTSTKYTERYTEPERDYRTESRTSRGRSSSSKSPNVVYIPYVDKHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMY6</accession>
    <name>A0A2R6NMY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMY6"/>
    <dbReference type="STRING" id="98765.A0A2R6NMY6"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="409" mass="46302" checksum="92B7697D9DA0FD67" modified="2018-06-20" version="1">MKQGHEKYLRRLHDAYSRLTHEQLVLFATARSLPTQGNDSELASRLALHDLTTYYFPPIQHGHPVNNATSVGTPKRARQVKAPDLPVEILAEIMDHVGDWELSKAVGVPTSLPQPPDWTSATQTDHAVLTGYLPLIRSADPSSHPPTRVSAILVIRFGYVHVLEYFLTHHRTIFKALYEYDLLPVTASHHGRTSVLSWWKHAREQCSSVLSLPSRASVAAAIDGASRNGQVVSLDWWLHSGIPLEYTEAALEMASAKNHLDVLAWWKEQSKGYGLVMKIGRVMDIASRAGHVEVLEWWARTQPEIKYDRQALYHASCHANVDVLQWWLNSGLQLIFDPDALIGATKHNRPEVLEWWDKSGLPIQYRMCDIEEALEDAIGGGEAAREWWKKKGVDFNANDKEWMKLRNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN63</accession>
    <name>A0A2R6NN63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN63"/>
    <dbReference type="STRING" id="98765.A0A2R6NN63"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="10">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR73811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="226" mass="23602" checksum="48FED2067E5CBA9A" modified="2018-06-20" version="1">MFRPAQPHTPPTPKPSTSAPTTKPLHVVVFGYPPDKYSVTAEYFRSLGDSTEPDQNTEIMNCFRIGYTNPGEAMRAVRKNGEVLGGAWMIGVKWADPAQAEAALGSSMIRSPFPLSSPPDVSSPGPDISVSDSSPTRGFPSAETSMALSTVQRAQTPTVGTPMKLAPSTSAFRKPGSGAMPGAHPVADASQRVVGGLHLPGSAGASMQSSVSKGFLGQMSDMILGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN68</accession>
    <name>A0A2R6NN68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001059">
        <property type="protein sequence ID" value="PSR73833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN68"/>
    <dbReference type="STRING" id="98765.A0A2R6NN68"/>
    <dbReference type="OrthoDB" id="2766819at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098636">
        <property type="term" value="C:protein complex involved in cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046871">
        <property type="term" value="F:N-acetylgalactosamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04327">
        <property type="entry name" value="ZnMc_MMP_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052487">
        <property type="entry name" value="Galactose-binding_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46938">
        <property type="entry name" value="DISCOIDIN-1 SUBUNIT A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="546" mass="59921" checksum="0C36C014D48BB252" modified="2018-06-20" version="1">MSQPHACAQLFLPAEDSERAIRAALTENPKNATYFSAPTPDGVAADAGMGGAPMALALSVRKMWAAGRTLRVSLRGGSEIVRSKVKQFAATWSQHANIHFEFVAQEPAEIRVGFEMNGRSWSYVGTDCLTIAAADPTMNFGWFTDVTPDDEFSRTTIHEFGHAIGCIHEHQQPNARINWDRNFVYNYYAVNSGWSRAQVDSQVFAQYDAVRDNIQSTVFDGTSIMEYPIPPGFTTDGFTVGWNNHLSANDIQFIGTMYPFPPTSLTSLETGSFNTMSIRSWDRPANENVGTINFTIPRPSPPTLLLGINWFDMGFNVNTRLLCKVVNVAQTSASINLQSFSDTVNYSSGCSWLTVPSGDSDFQSGHFSTADDHVWSSPQALTSRKITFAKAYSAPPKVVVWLDSIDVGYNCNPRFTVFASDIQADGFTIHVDTWGGSNLYLGGATWAAYSANRTDIRSGSYNITDVRSWDSPQLLNAGQVAFGGANFSKLPNVFMALNSIDVAPRVNPRIRLSASDITTSGMTWHLDAWSDTVLYTAGASYIAFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNM0</accession>
    <name>A0A2R6NNM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v10555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNM0"/>
    <dbReference type="STRING" id="98765.A0A2R6NNM0"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="310"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="633" mass="69563" checksum="4A42947A8C6A9D3F" modified="2018-06-20" version="1">MTTSSVQANGHGDYRNHLDSAEQSLGAHSPTSPSWRTFLRLGNQSSKKLANGSSLTLDTDSLPSEATLTPLNTNPSLAPTSASGVYVDQRSSYNSSNTLSSDSNSGRPSKNSSLRTPSTPSYTSQHPAEGIDTIKEGEENARTLKSKHSKQRLLGKSRVPHTANASQMSFIPTTPPASRSGPLSPKAFGANASRFIRRVASAPNAKGLFSLGSRSASTTTTKNGLLAPADVLAPIPLEQRRDSIETVSSGSSRGRPSRQTRAHSTSAKKTKDRVTNASANVEGPGKIAFRRTYSSHSIKVRSVEVGPGSFQKIKMLGRGDVGKVYLVREKKSSKLFAMKVLSKREMIERKKIKRALTEQEILATANHPFIVTLYHSFQSEQYLYFCMEYCMGGEFFRALQSRPGKCLSEDGSRFYAAEVTAALEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLAKQSSEPGGLPAMIHQEENGIPLIDTRSCTADFRTNSFVGTEEYIAPEVIQTSGHTSAVDWWTLGILIYEMIYATTPFKGAERNDTFHNIMNLPVHFRETPKVTSACKDAVTRLLDKRESTRLGSKSGASEVKQHKWFAKINWGLLRNTQPPFLSSVLQSADYFRAADLSAFEAIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNR5</accession>
    <name>A0A2R6NNR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001021">
        <property type="protein sequence ID" value="PSR74075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNR5"/>
    <dbReference type="STRING" id="98765.A0A2R6NNR5"/>
    <dbReference type="OrthoDB" id="2781456at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015312824" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45817" checksum="D29A26179737968E" modified="2018-06-20" version="1">MKSTFSLIVLVTSSVGIAFATSQYPVCIVGAGPTGLTVANGLESKGYSTVVFEKDPEVGGKCQSYYEGDFFHPMGALLFSNETYTETLPIILKSGLPFQPFAYTSKGWLFDWRTGVVNESPVSAADVYPLLKPDIDRYIEFWNSNIGPNLTTIGYKNGIPSEYTVSFSDWLWENQYNPELISIFEDGMVPYGYGDVLDTPAHPGYVIDRSGKFPIITYANPAGSEATQTCSKVILAFPPVSHALEAANLQLSAEEQEVFSPVEITKYWSGAIQVATPNGYAYSAVAFEPAGQLSAYLRLFDASPIATTWSWGKTGSKQTTAQAKKLLRSTISKFNKDPNNATEIPQPVTEEDVRQFEEWDYFPHYNTKDLEAGFYDKFNKLQGQQNTYYASGFNGFETVEFAIRAGQDIVATYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNV4</accession>
    <name>A0A2R6NNV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNV4"/>
    <dbReference type="STRING" id="98765.A0A2R6NNV4"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="9847" checksum="35F327EF0F9F92EF" modified="2018-06-20" version="1">MTCGGCSGAVTRVLAKAEGVSSYDVSLEKQEVLVTGTIAYDELYAKIAKTGKQDSCRYEDMVKMGGVYFYSSLMFPQDNAKDWTPWQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNW1</accession>
    <name>A0A2R6NNW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001024">
        <property type="protein sequence ID" value="PSR74055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNW1"/>
    <dbReference type="STRING" id="98765.A0A2R6NNW1"/>
    <dbReference type="OrthoDB" id="2796020at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="26795" checksum="05E8BBE159439C2B" modified="2018-06-20" version="1">MSISEMLLKAFNTDPKSYQEATSREDASKWITAMYDEIKLHMENGTWELVDLPEGRKAIKCKWVYTIKADGCYKAWLVAKGFSQQYGIDYEETFCPVARWESICFLLAHAALENWEIKSLDVKTAFLYGKLDEEIYMEQPEGFMKKGMGAKVCRLRKAIYSLKQASCTWYYKINQSLTKLGFVCTKSDAGIYVYHQRQGEVIVILYVDDILNIGPELKELTRIKEMLSKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNX1</accession>
    <name>A0A2R6NNX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNX1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9802" checksum="6C1224BFBD140363" modified="2018-06-20" version="1">MPGITTSPGRLPKLRFVLPSLSSKTKQLWVNGNMAPEGKSSLKDALKWARIEDSESLCEQEATPMTPNGKSDGRNRDNGIWEEGRGCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP53</accession>
    <name>A0A2R6NP53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001010">
        <property type="protein sequence ID" value="PSR74215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP53"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1152" mass="127183" checksum="C987A3BCDD710603" modified="2018-06-20" version="1">MAKTLRDVDEEKIKDTKEDIDTLLVFAGLFAAVLTPFLAETYQTLSEDPGDTSVAIQRHMSAQMSSYVLINGSLNSTVPAYPADEPSFVPPPFALSINVLWFSSLALAVVTASFGILVKQWLREYMAIETSRGAKARLRVRQFRFTALDDWKVFEIAAVLPLLLQFSLGLFFVGLCFFSRSVHPTIGWTITSIVSAWGCLFFFAIFAPACSARCPYKTAVTKKAMRALRKLIYNCHLVPYFYFGPVQKSGFPKEDEDAATDAQGDVQILTTADAILLDDDLLATTMSDSLEEIQSSVGPAGVIDFVVAALQQRLPGSGLITGPIELLDLGRLPERTWTALVKITAQTLKRGSVLQNDSTDDLQEWAQDAITIISTSYSSTFPIHVVDALTLCMTTAFVPTCLLIRDTQLLFTVMSGSSHARPIEVMNAVVVALQKSRCLPASGSITRRIASLDLSGLPEPVWAALVKLTAQTLERGLILRSEFADALEEWAQDAITIISTSYSSTFPIHVVDALTLCMTTAFVPTCLLIRDTQLLFTVMSGSSHARPIEVMNAVVVALQKSRCLPASGSITRPIASLDLSGLPEPVWAALVKLTAQTLERGPILRSEPADALEEWAHDAITILSTFYPSSLLPEAGEALASCMTAALGPTCQHIGSLKKLLTSDTSRELGRRENAGPSQWLSHILESFRGSISQLNIKDTPANDVLQFIFRLVHAIPRLCDGTCTHDRDQHDLGELLSSHADDVPNSTISSILTEYRNRLSPSEREADPQYVNLVVAADATLKDVDFLREALQEALQRSQHSYRMNCIVGVIRNWQKHATPSNGSTSILHFDNIPGDLWTMIMDYVRSLNDSFDTGLDADHTDWKGCVESAFIVLMSAPEDSTATEEELRMLSRCISSLEDRQSKVVRLILSLNVNPRRMRHKYYASIIERLSCTSPPTHFRLEETTLDAVSFIQSSVCNVACNHGSRLGEMYTAHQDQVFYRIAHFLMASATAAKTCLGETSLSGLDDFLIAIFSDNHFYRTWKQRIHIAISASACAMADIHVLDSIYRPSDAFGHETRIWGLSLYYLIGELQHFQTLRIQLEQDNVSFVEVAGKCLDLLGSQPDRSAIETFLKAVSSSWGGYKLKDLIRALKVFIPEDKVSQYPILDALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP64</accession>
    <name>A0A2R6NP64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP64"/>
    <dbReference type="STRING" id="98765.A0A2R6NP64"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="243" mass="27054" checksum="9CF1FA8ADEBB02A0" modified="2018-06-20" version="1">MSSGLAISAGRKLFERNLDQYAPADPLYETYVDKKGRERRRKRELPPGLSARDAKILKSVKRRAHYLDKGFNLCGLRFGWTFIIGIVPGAGDIADATLNYILVVKKARQAEIPDWLLRKMLLNNAVSAAVGLVPFVGDIVLATFKANSRNAAILEEFLRIRGEEYLKRENQRVENPEVVRPGAGREEAEHVPGKDVKEDGGWFRRKSKSKSKSVSPASNGAESTRRESRFVENVNGDSGSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPI6</accession>
    <name>A0A2R6NPI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v9891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPI6"/>
    <dbReference type="STRING" id="98765.A0A2R6NPI6"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="440"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="754"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="829"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR74383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="895" mass="101637" checksum="6195D920E0763FB9" modified="2018-06-20" version="1">MTPTSAKRTAVNFPDTRPTKRQATSSPEEGELDDGTPPPLPSGLTTGSLTPPKAASKARSRVPFPFKKKASTSDTRPEYPPEVPQARGPPLVYNRSVEDERRFRDDDLRRGAHARPPRHDPPSARLGDHWVSNHYDDRAPRSRWESQDIRHDTERLYQPRGAVDRWARDEVPQPLVSPRPQRRSRSPSSPRSTGSPLSPESNSKEKHRLPRPSLLEQDSRSNFDYDRDRDWSGTRDSRDYKRDRQRSSPGAITRKGDSYIPNDDDDRHYRPRRDSRETWRRREDDEDVRRYSDDRDDRGSRRGFDAYHPLSPHTPPRQFSPLSTHRVPDGPVTPPLPSEAPPPPPPNDPSNALPTEHAMVKISLPKKPPTPIAHVPLSLIAVKEIPKSEPERVQIENESIKEQAKVIVHRTRRKPVVRTREEEKALYGRIFHGCGMQSDYDVINKLGEGTFGEVHKAIHRVKGHPVALKRILMHNEKEGMPVTALREIKILKSMRHPCIVDILDMFVVRSNGKESPLSVYMVFPYMDHDLAGLLENERVKLSPSQIKLYMKQLLEGTEYMHRNHILHRDMKAANLLISNTGALKIADFGLARAFDPNIVRGGDVKDAHPGKERKYTNCVVTRWYRPPELLLGARQYGGEVDMWGIGCVLGEMFWRRPILPGSSDLDQLDKIWQLCGTPTQITWPNHDTLPGCEGVKRFNMYPRRLKQTYETIGPETCDLLDKLLTCNPRERITASQALDHDYFWTDPLPADPSSLPSYEASHEFDKRGRRNQAPVGPPVVNRPDVPSRPLPVPTQPPLHFNGRPPPPRESFRGSHGGPAPYPPFPPPQQRFSAAPSSLPPYSLRPGQPPPAIWQPPPDRPAHLPPRPAFITGREDRSGGRHQWQNGHGGNELNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPK8</accession>
    <name>A0A2R6NPK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v9846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPK8"/>
    <dbReference type="STRING" id="98765.A0A2R6NPK8"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="9">
        <location>
            <begin position="161"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR74434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="558" mass="62211" checksum="60B3F8D2E3500CED" modified="2018-06-20" version="1">MSQAPPRSPPVPVRSYGNSHFSMSPGGHTNDPPAFSKGSGVSLDYVDSRNMYRNEKGEEVDIVPGAVGLLPGEVYDRQLYPWVAVFRRKLQSNLVWESDAIASMQVCSLSRDISGTHGAIKRKLRTPFLDAYFVNTSSLGTHTFFMTLLPAFCFFGYHEITQGLIFVLALGVYASSFLKDMVCSPRPFSPPVTRLTIGNHHLEYGFPSTHSTNSVSIALFFFTFIHRLAKTPVAALTPPIFPSQPLVQNATDLVQEIIPQMKVSQTAYWISAVVLLFYVFSIVYGRLYTGMHSFTDCAVGVLLGTAIWVLYVLYGDTLDFWLKNSGWIVPAVVIPFCLLLVNRHPEPVDDCPCFEDAIAFMSVVMGDCLTRWHMSQHGYDHRFFVRVMPGKAVGTFTEMWAWWTIAVAKLVVGILTIFAWRIFAKFLLHRILPPTFRFLAQLVTLPHRRYYTPATDYTNVPQDKGLRAIPSVLDLPGMFELEMDGVSTARAVDPLTARRRDIKLRNGGGRGVGKSEKFADGFAQEGLGLGIEEMGGKEADVVKHYDADGLGPRIRAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQK3</accession>
    <name>A0A2R6NQK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQK3"/>
    <dbReference type="STRING" id="98765.A0A2R6NQK3"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="265" mass="29090" checksum="21B56C280CC00F32" modified="2018-06-20" version="1">MSCEQCTQGYVLPGEPAGSIVDGAYFHPAPEGSPKSSAIVLLTDIFGLPLKNSKLIADELSKGVGCDVWVPDLFAGNPPFKVEELEPLMPQRPSESITFVNTLRMIVLALSRAFRLYGVRGSVVDSRINSFIQKVKEEKKYEKIGAVGYCFGGSVGIRLGQTDLVNSLVICHPGGCTVAQIKAIKVPTSWVCAESDMTFKPPLRNQAEAVFAARKEKEDYVDYEFKDYRGTVHGFAARPNLGIPEVYDAYKAALDQTITWFQKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQL3</accession>
    <name>A0A2R6NQL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQL3"/>
    <dbReference type="STRING" id="98765.A0A2R6NQL3"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="549" mass="60476" checksum="E8684DFE3C243DF3" modified="2018-06-20" version="1">MAENYWVAIGRELESGCTCTTLDASGRVCDRGCVCLSVPVPTGRPIRTFSPTGDCMTVRTVSRLKPLLRELLEVLVSIIQPPSGRPEGVSLHPHLLHPQVEQNISHVSYLRSILDADLIQQEIEHGLFDPSGVFQAIGDIIRCYCAPMRDRAVDQMVTLARSCVPGGTGTKTDAVRAIRQCFEIMELMKLTLRPYLVHSAAQFELKTFQENRHQKIPLSLDTTRAWFTSAYLELVAQNTASPPKDSAIPSFSKYPRGVQIQVAITKAIVNLIFHPPSSSTPCSSTSSSPNLPSSVNSRYPETLYLDHARLNTLRTDAADFTSLYMLLMLYRQLVHSSPRKDGSRTVVKQDELLALKKEIWEIGPAHLGHCFMRGTKSGDFSETSEKAVEATKWREDIGNVVLQLTMRASEVRSQPYIPTPSSSASTVSGKPPLTPDQNLLKLATSWTESNLRPESSLSALMKKRVRCAVEDAVVEMILPPSLCRKPGVEAGASPSIEHATSGLEPLMPEIRHLAEKLKKLIHIHTTVYGALYAQPGFLVDQPPPVDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQR9</accession>
    <name>A0A2R6NQR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000943">
        <property type="protein sequence ID" value="PSR74946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQR9"/>
    <dbReference type="OrthoDB" id="3265515at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="184" mass="19832" checksum="01460FD35DED899F" modified="2018-06-20" version="1">MPSHGTFPLAKRSMASAANDGMGRADIRIFSDASRMESGLGSAAVLYCPGHPEMVLRVHFPASVHTLTSLDGEIIGLTLALILLGHFLSRADTAKACRVSIGCDNTSAIDFSRKRTSRTEVVLNSLMAQLKSSRPQVKLSFHHVKGHSGIPGNQRANAEARRVAQDETCSTAMRLPPSLRRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQY1</accession>
    <name>A0A2R6NQY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000943">
        <property type="protein sequence ID" value="PSR74947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQY1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQY1"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21450" checksum="9F6A3EF692038E7A" modified="2018-06-20" version="1" fragment="single">MSAYGAITTRNRPSGPLASTLWHCKPRTSPSAKYLTIHHLTLADALTHSGLLQYLHTCFAEELERGMTYPQEILQGETYTQSMFEGYFFGADVLLGVVGEGDLPDGKNDGSVVELLLDVARNGRSWEESVAGVYYVKPNYPGRSSHICNAGFLIPPAQRAKGFGAVLARSYLHYGPRLGYEASVFNLVYVNNVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR22</accession>
    <name>A0A2R6NR22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000930">
        <property type="protein sequence ID" value="PSR75101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR22"/>
    <dbReference type="OrthoDB" id="2682158at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="228" mass="25532" checksum="D15EE143C60F97F8" modified="2018-06-20" version="1">MPRTHSKAPANKASARRAGQSTDKPAQQLIPVPDGEAGRRPPRGYNLQEAMGLGGKDEKYYRYLRKVKAIARRFLTAGLTISRQPRLTVAKVMNLEHAFFARFEQGWPVYVILKQYYSNSAAASKRNEERDCAASVVSSEEDASGDEDVSSRKRKRGTIDDTRDSADEGGNHWEIPESSEEEEDVPGKVMPPVKDHMYKRLPLKKKTVTIVSPVASPERTSKRKVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRB8</accession>
    <name>A0A2R6NRB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000924">
        <property type="protein sequence ID" value="PSR75149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRB8"/>
    <dbReference type="STRING" id="98765.A0A2R6NRB8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="500"/>
            <end position="501"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="541" mass="58913" checksum="CB5B03D2DC9BF1CD" modified="2018-06-20" version="1">MSTPTQAEYDVIFAGAGTSGGVAAGRLAAADPSLKILLIESGPHVREDDSFVQPARCLSHLRADNPIIKVHVSNESEYLGGRSQVVTCAHVVGGGSSINFTMYNRAVASDFDDWENVFGNPGWGSKEIVPLLKKTETYQVAPGKDDIHGYTGPLKVSYGGKLTNIGKDFLDVAQKFDKTRPISEDPNGIFTSNVWIDGETGKRSDVAHHYIYNHPSIEILTGSLVKRVIFEGNRAVGVEYVPNPRFQPDSTAEVKSVRAKKLVVISAGTFGSPGILERSGIGAKDVLEKAGVKQFVDLPGVGENYQDHPTIFAPYLATKGSDTLDGIGRGEPEDVASKGLTSLPICLLNPSASSEWHAQWLKDGQGMMAHKYIGDPLSVPARKYFCMGYFPAYPASMGHVHIKSGDVADAPLDFETAYCKRPEDLAILKFGYKLSREFARRLPCYEGEYTPSHPVFDEASEALCKQDVKPVPVDAPRIKYTPDDDVALEDYLRKFVVTAWHFLGTCAMKRREMGGVVDNNLNIYGVEGLKVCVFPVPTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRZ1</accession>
    <name>A0A2R6NRZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000882">
        <property type="protein sequence ID" value="PSR75617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRZ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7075" checksum="A18130ABEFA521D7" modified="2018-06-20" version="1">MSTIAFMGLAILTITAIICLHAYVLTKFMLLMNQIVKGSQASTYNSGWGSYDNNNNNAGGWGNTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS12</accession>
    <name>A0A2R6NS12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS12"/>
    <dbReference type="STRING" id="98765.A0A2R6NS12"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="108"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="36225" checksum="8C7976FC72AEF1C2" modified="2018-06-20" version="1">MPPLRSMPVVCQNVCNARKPGARPRSLSMADPLQDIPSIPTTPTLRPVMEGSPMLPGSPPDELLDPVWDRVWQMKAKALEALPSKVRSLQAVKDTAIEQQDLRQALGRIKRKVSATFKELEDGRTVSATFDMSGVRKQDMHVSFRTNRLVVTWRRIKTIEKMEDRVLVRERKEKQYKQTIPLPDGTQFDEVRACRDGRQLVLTYPNSRCVRVDPTMGLPTRENSSHSSSTAWSSSGATDFETCRSVHSAAVGFLEELIVEKDGGNLKVEEVCSKRSVFNAPKKSDCQSQASAKTFHAMTPCFTVFSFFGDNASAFSEWNMNGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS23</accession>
    <name>A0A2R6NS23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS23"/>
    <dbReference type="STRING" id="98765.A0A2R6NS23"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27171" checksum="A6CBD557820E2263" modified="2018-06-20" version="1">MPNSLEVVREKLQATAKNAHIVKKGSLVSDADGTYSVGPIVRRPFYEGGRAQFTLDRGPFRTAKAYYLACAQRELDCSRTLFVQSASPSYQKDLEDSSLQVERCVGLLSDLVNRCEGLDDDDPVLAPFSLDIHDIGLKNILVAPDDHTRIVAIVDWQFVNIHPLWCCARLPTWLRPSLSDGDEPTKSRLSTIFRAEIARLDGLDDSTFLHALDATEDARGTLDDLADYDAFRDAFLLLPALENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS33</accession>
    <name>A0A2R6NS33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS33"/>
    <dbReference type="STRING" id="98765.A0A2R6NS33"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="355" mass="38852" checksum="CA13A2FB712C3DC1" modified="2018-06-20" version="1">MDPTNKPKGPSPHYSLYQREVFKRGGEGGESTIFGHRIPAPICFAPIGINKLYSARGELIPARIAGELGLPYCLSTAASQPIEDVAAVNDEAASVRNESNSVHHYDGMRLNVKALLYIFNHILGLNGGNAKSPRFYQLYMGHDDDITISLLERAWKSGFDVLMLTTDTWQLGWRPTDINIANYVFYYGGTVGNELGASDPVFMRKYGKELDKDSGKWIDSSVWHGKAHTWDKIKWLIGEWNRISGGRPFVIKGIQNVADALKAYEVGCAGIVVTNHAGRQVDGAVGSLEVLPEISQAVGDKMTILFDSGIRTGADVFKAIALGAHAVMVGRLYVWGMSHEGDSGCRHVIKSLLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSW4</accession>
    <name>A0A2R6NSW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSW4"/>
    <dbReference type="STRING" id="98765.A0A2R6NSW4"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29368" checksum="47B6E4D82A32B851" modified="2018-06-20" version="1" fragment="single">AGVPLTSPQLYSAGHTDDLRTALLFISRLYPKAPLLGVGFSLGANVLTRYLAQEGDKSRLLAGCALGCIYSKGMGANLTSVIRRHRETFEAFPEAEVSKAASGLIQQSGTTLGQFDETITRLAGGSSPPFPFPSARDYYIWASSHKVLGDIRVPFLALNADDDPIVTVLPVHAGNSVLSPWVVFGVTQGGGHLGWFEEGSAPGRPHRWYRRPVLEWLKAMGDDAVILEERKVVKIIEVDGFLMEEGRDDIGCKEIQGGGHVVGVKGEGGLLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTA8</accession>
    <name>A0A2R6NTA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000858">
        <property type="protein sequence ID" value="PSR76217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTA8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8275" checksum="DAA1AAED9A5EC111" modified="2018-06-20" version="1">MVGSILAKPRRVLSLGLTGHEPQRIPLPKTKLADGQETDLIQDEVEVSRQRPRFAGVFIAFDGLLAKHGANLAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTS8</accession>
    <name>A0A2R6NTS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTS8"/>
    <dbReference type="STRING" id="98765.A0A2R6NTS8"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="310" mass="34585" checksum="4826268599BF4527" modified="2018-06-20" version="1">MSSYNKELDPYSTKAKEANANLTPQQKIDGLHAIVKKVKTAMLTTRDTDGHMHSRAMAPAGPYVATQVNLVFIANKASHKFEEIKNDAHVNVSFYDEQNTNWASYCGIAKVSQDKDLIAKHWSSMTSAWFGDLKDGVHKGDQHDPRVTVIEILVDEVRYWLSTESTVAKMVDISTAALTGRASAPGELRTIGKEEHQEITDILLDEGCCKEKQITAASRVPRWVSPGPGYAFFEEGSTREVEYCNDLKSRFWRTTGQMEPADAEVSCATRAKALPPREIRTRTRETRIPPTSDVETVVLAFSGFQCEEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU67</accession>
    <name>A0A2R6NU67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU67"/>
    <dbReference type="STRING" id="98765.A0A2R6NU67"/>
    <dbReference type="OrthoDB" id="2626014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="783" mass="87034" checksum="ACE1CD355A21C76F" modified="2018-06-20" version="1">MYSYRKHLQQSAPKFPSVRGSARRSSKATEAFASLESTAGALQSPAENNEAYDHSESLLFSEDDLVDIDPVEFWATAASYPHLHLISQNPQAHGLLPSLNPRNSILRLKSLTRRASTHETQALITRSSSTKHSRRFLDSTSVPVVDNRASVHEFPHFPSPSSSHTRGPTDRSSSDPRRVDNLISIFSEKDPFRSTRSPEESFHRTELAEAVHHTQEEVLDPNSILPSPPDTCFATPASITPSLAVSSVGLNPIRRSLKRLKEFTKGNFSVFHNPPEVCQILPSESTRHPRTPPQSRNFVWHLPELSFDTTPLSSLIPQEQEYTPETSVAEQDHHEISSPALRPSCTQTARFPLIKWERVNPNELTPSPYTILGTDLSPAQTPLSPIPSPSWLSRNTRDIEFGRTQPPPTIQIAPPSPAPLPILPRSLLPVISRPISAADSLSPKGSDNSSVTLYSPSKHLPRLTIPESVSRSPSINQLSIVQFHGALTDRRSSIHSFISAALSSSKSSPLNSAVESLKPHFLLLRHPSQSSRNRTSGFTPTPSPLALTLPVSFEPTGGITPDTPITPVQPILYEVFKPSPQAFAQSNDIVPLPNYLLALINSTYRNSKNIPNMPLNIYGKQEDTVDWGDEVDYSGYEWFKDPPPRPEPAPAPPVVEPYVPQPGVIEQNEMFDFALKSAPSVLYGRYKQYGQLGVLGWCPEFGELIDALKNLGFEGNMFVSTRSQALKTCEDILKLNLDIEMQIIVMHLSSQIARLRRFLDSDRQWEDYPQPRFPMDPHVQYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUC1</accession>
    <name>A0A2R6NUC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v8176</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUC1"/>
    <dbReference type="STRING" id="98765.A0A2R6NUC1"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="170"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR76795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="438" mass="48476" checksum="434D2315B2DCB390" modified="2018-06-20" version="1">MTEASAATKSNTCKSENLPSPGPLTEAQRKLVKATVPVLEAHGQEITSRFYKEMLEANPELGNVFNHSKQQKGDQADALARAVYAYAANIDDITPLRPVIERVCNKHTSLHITPSQYAIVGKHLLQAIAEVVGTNVFSGDLYEAWVVAYWQLAHLFIDREAELYKQAGWVGWKHFVVSRKVIETDDITSFYLSPKDETPLPPFRPGQYISVQKFVKELGLYQSRQYSLSDSPNPNHFRISVKRERGIRAVDSSTGAVDLAQDMQLGLISNLLHDTLIEGDGIEVAFPYGDFFLDDSIAPVVLISAGVGLTPLTSMLHAVLEGPSPRQVSWIQVVRSLSSHPLNAEVRRLLELKPSLVRRAIFYSDPGAAVGEDCDFKGRLDISLVPTETLRLDDPIVEYYVCGPEAFMVDVIRGLRLRGVSIDRIHVEVFGAGAVPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUY8</accession>
    <name>A0A2R6NUY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHLCEN_2v8045</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000812">
        <property type="protein sequence ID" value="PSR77137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUY8"/>
    <dbReference type="STRING" id="98765.A0A2R6NUY8"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="308"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PSR77137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="359" mass="38924" checksum="EA7A1C9FEA5501F9" modified="2018-06-20" version="1">MRITIDGTLQEGVTSKDVILHIIGVVGASEGTEYVIEYAGPVISGFSMESRMSICNMSIEAGARAGMVAPDNTTFDYLRNRPFAPKGEAWDQAVQYWKTLTTDENAAFDVEIKIHAEDIVPTVTWGTSPQDTIPITGRVPHPASFEDPVRRASAERALKYMGLVPGMLMEDIKLDRVFIGSCTNSRIEDLRSAAKIILAAGSDAKVANGIVALVVPGSGLVKQHAEAEGLDKVFERAGFQWREAGCSMCMGLNSDRANAEERCASTSNRNFEGRQGPGSRTHLVSPAMAAAAALMGRMTDVRKLVKPDIPPPSLSRQGWTMSSQHRSIQSHPSIRISPPKTPSFFPQPVNPKPLRPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW12</accession>
    <name>A0A2R6NW12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000765">
        <property type="protein sequence ID" value="PSR77966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW12"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR77966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="14919" checksum="D649C387866F3584" modified="2018-06-20" version="1">MGAAIPHLIQLATSLPGILPYAPEEIQTEVLTGTVEVQDEVIPEDEDEDISYRSRGKSTISVVIKIGDGVDEGARTGKGRNNWRNGVAPASGGDSRNNRQGRKQNQAPKDKPRGSEEKRTAEPERIVIREEDMENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW88</accession>
    <name>A0A2R6NW88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000785">
        <property type="protein sequence ID" value="PSR77681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW88"/>
    <dbReference type="STRING" id="98765.A0A2R6NW88"/>
    <dbReference type="OrthoDB" id="3257342at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="300"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="517" mass="57429" checksum="DCA8E4ED7D8B2DA0" modified="2018-06-20" version="1">MASNRVSRRTAKPSEKQKSIDAEKVTQARPKPIPVPRKERAATEQVRKASSGSFVSKTVQLVKKVVTPRATSKGTTPIQHAASKKRPVADPQPKTSATGSRPSETSGANDNGSMRQINSANRQLPPSHPIAQRARPPPLLPHRPSPPSPPIEELHGGMPDNQAFDDDEVDGQYYAAGPPTSSSYTSDMEPDGIFDDEIEEDDQPRPARYVSQYSSPSPEAQGMHVNDLTFVDDLQEGEDPLVEAAVTGNSSTGTGKRPRSPSTDDEKLPPTPKAVKIVDHSGRARQQDYDTVVKEVIKIAIDLYEVKLITVCGFPSSSMEVDWVTEVWAEACRREGVKYRVTSDLHKMLTRRGTHLRSEMKNKGRKTVTVYYNLKPGQSERSKITNKKLVGKLLMEEEPDRNLFIYPIEFCLKEWSEGHFEDTTFTVGENSVVFASHLADLDKFERLTLRHELYHKLATKLLTNARYYAGVGATTDVPTAGRLSDKVFENMMKAYEERGDPESESDVPDKASDVDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWI4</accession>
    <name>A0A2R6NWI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v7436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWI4"/>
    <dbReference type="STRING" id="98765.A0A2R6NWI4"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="101"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR78314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="413" mass="45353" checksum="FAE4D8C3F5C3C045" modified="2018-06-20" version="1">MEQFYQPYVSYHSILDSYRLTSILRAEIPIDPALQQQSQQPQHNTTAYSHYQQYYAQTPYYQQYTPQTAQQQTQVAAPVPAPVKPVVTAASTIDTTDVSKLNDALGSAGVDLRAEEESLQRSSDQYQSYRPYEDRSRKQPAKPNFDTRHLGAKIREFGTQHKVTKVPEESVNYMALALRARLQDLVEAMIQASEHRTDVQFERPASLYEDESPMWSLLIRADVAKQLATIERVEREEEMKVRRERKERAEMQAAHSAAMQAQQSANGMAVDGGDGMEESGPKKKKKKVDGPGVTARNMSEDVRKKMSNAVASQAAGLGTGKYAWMTASSSAAAAKPKAASGGGLSPATTTAPSASQGNGSTWARPYVPAKITPGASATKEDDTRRTVTLRDAMFVIEKEKGHGGGRGAAMGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXK9</accession>
    <name>A0A2R6NXK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000698">
        <property type="protein sequence ID" value="PSR79357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXK9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="9244" checksum="F7881A71074935FC" modified="2018-06-20" version="1">MNATGKWAQYECRCQVTSDEHQWRAQECASEVVRSSLAGEQMIEAKRKSVTKGENEDVKRTEDIEDIEDTESENEDIEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXP7</accession>
    <name>A0A2R6NXP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXP7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8153" checksum="BA6CF8F2E2724766" modified="2018-06-20" version="1">MSGGAVSTTLYPFIGRTTSSLQGFLQRNVEVESQTVFGLAHLMAPGCVRQTTLNMYLMKDTQQTATNPHDKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXP9</accession>
    <name>A0A2R6NXP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000696">
        <property type="protein sequence ID" value="PSR79396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXP9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8226" checksum="15B9C0993CFB0DC1" modified="2018-06-20" version="1">MQLKQDNVSIVAAAGKCLDLLGSQPNRSAIETFTNLKVMSSLCGCTYELKDLIRALKAFIPKDRVSQYPILNALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY17</accession>
    <name>A0A2R6NY17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY17"/>
    <dbReference type="STRING" id="98765.A0A2R6NY17"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="54"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR79663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="349" mass="40016" checksum="4396FE6966AA42AA" modified="2018-06-20" version="1">MLSSIRRCLSSKHRIYFADVVFADIFTSFAKVLGDVWLSVLMMLPGGSLLYPPHQDGLARWILPTLMSVPYAVRFRQCLVEYLFPENESRRPLYNAIKYATAFPVIYLSAAQRLVVVEHLAVNLEEGSSKSWYGGHPLLRLWLLAAAINSLYSFWWDVTFDWGFDLLRTRAKATNTSANRTSSPPRPLMLPRLHSRSALLANAANADSNGISKEDISEDGQVAQSSPHSQKRYPFGLRRTLLLPLPIYPFAIIADLVLRLTWSVKLSSHLHAYAEGDRLIFLIEFAEMLRRWMWVFLRVEWEIVKEREMRASLPAGTRMRRRAPDASMEDEFEMLNGRSSYDRDRSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY58</accession>
    <name>A0A2R6NY58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GET1</name>
        <name evidence="10" type="ORF">PHLCEN_2v7101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY58"/>
    <dbReference type="STRING" id="98765.A0A2R6NY58"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="169"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR79243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="227" mass="25481" checksum="175CC1CF13E808F2" modified="2018-06-20" version="1">MTLIATIFALVFVTELISWIGKSVLLELAYALYLRVFYSSKRSQQQRLKSEILANKKELMLTSAQDQFARWAKLRRSVDKGLADLEKLNSELSSAKTSFSLKFNTALWILTAGSQFVVGWWYRKAAVFYLPPGWFGPLTWWLSFPFAPAGSVSCGVWQMACRRVIKTGERVVKELMSGKQRILYDRWLHKYPLAIGGSCLLIYCIGSPGPVSVPSGAQEGPVPDKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYV5</accession>
    <name>A0A2R6NYV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v6628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NYV5"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR80712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="213" mass="23693" checksum="FEB3F82B7D580FE2" modified="2018-06-20" version="1">MPAHQEWVENNNQYAATFGEKGALPLAPAKKLAIVTCMDARINVYAELGINEGDSHIIRNAGGCAKDALRSIIISQRLLGTREIAVFHHTDCGMLTFNTPQLRKLVKDSDPSNPALNAVDEIDFLEFNQLEQSVKDDVTYLKENPLVLAETTVTGWVYEVGTGKVRSFLRFSFSFISNFVAWSISNLFFIDPSGGINWDSGYAFLYHQSKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ53</accession>
    <name>A0A2R6NZ53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ53"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ53"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34452">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34452:SF7">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="562"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="717"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR81119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1171" mass="126829" checksum="47ABCB018329FA99" modified="2018-06-20" version="1">MSATPGKGRVSGIPAPGKSSSIPTPGRPRSASSAAQHPAINDDEYISQAFADAIRANDPANHRTSFMDDVSLSASSANYAFQSGRKSVAGRPSSATSSSSAFSSGPSRNALSSAKPVAPRPSSRASDVFTRSSSRAGRTFDIGDNVRLESLGFEGVLRYLGDIDGKPGLYAGVELRGGFAGKGKNNGSVGGKQYFSCPSNCGVFIAANKLSPPTVGAGAISRPSSVASTRSGRETPLSGHSSANIRKTPSVSNGRVTPSFPNGRITPITNGRITPVTSGRMTPSTSGRRTPGTTLPTARSRSATATQPLITPVRLPTATTSITPGSRASKYVGMTAKQLSTRTTGSSSPVRGSVSSPTRSFGVASSSFQGSHLASPSRTSTSPFTPRAARSQAIGVGVPAGTPTKTRTALNTPRARVPSAVAMPPPPSPSGPSLQSRSVSLNDPILKPQREYASLDGPGGSVDFKSGRVSSLDRTSRPSSSASSYPELQLQNERLQARLDALEDENRRLMTDASNAEGSLSSLSGRLDSLTREQDTAAARITDLEFSLRTAERTVGERDSTIESLERSVQQSVLDVEKVRSEGEARARDIQSKLDDKEALVIQLKEIVEAKEGLESENDAVLSVKNTEISLLESRVQKAYIELEEERRELGAQVDELRKAGQETIALYEERLSAADGRRYELEDLISSLEEQLRMQARPQSPASMARKASSAMEIDNEALREQVQHLHKKIASLEDALEEAHLTSEREEAAIHEKVAHYKEREESMRGELSDSEKEMERVMKSEESARLRIEEIEEALRENTVALENARAEIEGLRAEIANLESIAAGGPQKAPNRSAAQTTGAYELLKAEKSELEHICKQRDEQLAEEREASAVLRQALDERIAELDATRKKLNRELPVNGLQDPSKPSVPPSPSKHDLATAREEIKGLKHIVQELQMENTNLAQRYKVLESENKLLMSETEQLREDMKQLEDNIEQSLLREEEALQAEEDAAINGSSDNVSTLQKNLRDAKTKYEAELDQLRKRLSDLEMKHARTVHDLNKEIGELESLIESKDELEREVERLKERSARSQKKSSKGLPEEIRAPTSVASSASKMSQYSDSTEHGGGEVCEICERPGHDIFTCDLLNDDRPLSIGSSSGLSDTKQDLYCEDCESRGHTAANCPHSLDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZA1</accession>
    <name>A0A2R6NZA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1168-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZA1"/>
    <dbReference type="STRING" id="98765.A0A2R6NZA1"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25253" checksum="F0A85CEB14236B93" modified="2018-06-20" version="1">MSASPSVPSSSTPVNRHAPTPVERQRSQLDKLLKDPTKPAYVPAPPKEKNIRPPREMMKNVQGSSAGAGSGEFHVYKASRRREYERLKLMDEEAQKETETEEFEKKKREREEQAETKTAKNRAKRQKKKERVKGKAEDKALDERRDLGRGSTVDIPLKKRRLVNGQELVFKRPGEESDEDDETDEQPRLTTGGTHDLARAILPNQLAAPVVDVQRIIIHEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZB1</accession>
    <name>A0A2R6NZB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZB1"/>
    <dbReference type="STRING" id="98765.A0A2R6NZB1"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015218207" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="24"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR81173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="354" mass="39617" checksum="36DAD220AC6A0DBD" modified="2018-06-20" version="1">MSPGHRWYLAGAFLSSLVSCTNAFYLPGAAPHDYHEGETVKVFVNALTPMLAASDNAKIFHFCEPDGGPKSEPESLGSILFGDRIFNSPYNVSMMRDNTTCHVLCRQDVPADDAKFINDRIREDYALNWLVDGLPAAEMKVDTKNGDVFFDMGFNLGDDEGAYAEMPALNNHYDIVFKYHEPQPGSDVYRIVGVLVWPASIGGNQDSDTNCDTSEDNKFILNEETSNRVRYTYRVTWSESDTPWATRWDNYLHIFDPRIHWFSLVNSVVIVVFLCVMVSMILLRTVSKDISRYNAIDLSEEVQEDWGWKLVHGEVFRTPQHPMVLSVLVGNGAQLAAMVGVTLGSSGAFVSCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZM4</accession>
    <name>A0A2R6NZM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZM4"/>
    <dbReference type="STRING" id="98765.A0A2R6NZM4"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="50"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="819"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="976"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="827"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR81341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1018" mass="114203" checksum="28703FD18660E4D7" modified="2018-06-20" version="1">MKVSLCVCSFQHPKFSAARESHKAQRVLHDQRRAAKPHSALLVEAKEAWALARQKNLSKEDRTKHVHALMEVIRGKVRDIVFKHDASRIVQTAVKYGGQKERNEIAVELKGKYKELAQNKYSKFLVTKLVRLCPAHRQSILLEFQGSVLRLLLHREASSVLADAFELYANAYERSLLLRDFYGKEASLFSLTAGSEDEKERSKKGMKGLIEGADKERKKRVMNAVKDNLTTIFNNPDKGAVSHAIVHRALWEYLVAVNDLEDEADREKLRREIFESCQDVLAEMVHTKDGSRVVREFIAQGTAKDRKHIVKTIKPHVERMCKDDEAQLVLFTAFDIIDDTKLTAKSLVADIVSSASTLYSSPQGRRSLMYLVSPRTRRHFTPAQISLLAETDAIRAQTSKKDEQIRTEEIRKAASEPLIAWVAGKGGEVVRDPGGSLIITEIMLYAEGDKTAASETLLKALTLPYPSTDFSNPHLMSLPHSSRVYKTLLQGGPFSHTDKAIVRSPSFSPVEFAKRFVRIVGQENTLAMAKDDGAFVVAVLCERAKESEDSELKDVLKTWFSGDVRKELEEDKERRGRALGWSDTWHLSHLIDPESAIRDTPESRPLDDSIGGRRPQHVLSLTSTTSSDILASYDDLSPQPAWKQPSTAYEHDTLPLPGNVGERHDALELGSFYGHEPYSDSDIYASPQGSQNLGKEMDAAHESRNIVNGWADEQPRDYEVLSRYSDGRNYALFPHNALDPKLLAGYQQADETIEQYDQSEDEGEEYDTVASQVATGSTPFLNTYEDPLRDSSAAETLQENVERAASQFEFTFSFPSPVQLDDAAHRSPTPSSPYSSRESSPSTIAVEAPPHLHSQHTLVLEEADTISSAESCPLGCGETVSMHDALYHVKKHHRPPGAITRTLITCPLCTSNPNLQWRNFPRHVQSRHYVEKVVCPCGKKFARLDAKKRHWDDSCLTNPLSLKSLAFAAKRNNLPAKGLKAMKKERGPRKSRQRNKRAAEDDNEYVGSKKTAKKGRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P001</accession>
    <name>A0A2R6P001_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P001"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="9228" checksum="FB464F1B5BFC785F" modified="2018-06-20" version="1">MPKSEKTGQNSSRGAKEEASLRPLACPQTINNNARPSLVSSEILHAFILILKPVLFKSRRATLENPAGPTVEVDFPGARGRSSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0R5</accession>
    <name>A0A2R6P0R5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0R5"/>
    <dbReference type="STRING" id="98765.A0A2R6P0R5"/>
    <dbReference type="OrthoDB" id="3159295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37458" checksum="AB882BFB36FF1207" modified="2018-06-20" version="1">MSHGYLKLQSTSAPPVEVIDRIVQFMLGYKHDFTIIADFSLVSYQFRQICFRRFFSSLCAFSKYKWANICHIPGVFNWTRSLMCDSNALHIRPDTLRQFLKLKTVQVNFSSEGRNTQLTSTKLILPCIPSYLTHLQLGYLPLIDATLLQRISSNLPALEFLELTCSVRLEPDCCWDCYEEAGSHTIHSPIPDYYCSAQDLACAFGEALQPLNKLKDLFLGIYLSEVNIFYYHIDHGFRRMRLLRTDPYGPEQCRQCHELYGEEVRQQEVAASASLARFLPSLKILGWNSFFAHEEDGDGWAEQRTTILIERVDEWIIAKRQTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0V2</accession>
    <name>A0A2R6P0V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0V2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="6813" checksum="B9E1D67FCE35A702" modified="2018-06-20" version="1">MNLGIPPMSNPPPPSTFTLPELDPMYNGQEIYLSVAEQMFECVIEQTTKKASSSYMGASSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1D0</accession>
    <name>A0A2R6P1D0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000563">
        <property type="protein sequence ID" value="PSR83276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1D0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="8949" checksum="28D0470A411E7B1E" modified="2018-06-20" version="1">MTVAASPLQVVLPESGQNRVRCSTFTGTASRSTPHLEDAVQLRVILRALERSSTGGVTGYDLVQYPAVSTSTHLTMCNKTLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5I2</accession>
    <name>A0A2R6P5I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000527">
        <property type="protein sequence ID" value="PSR85713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5I2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR85713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="283" mass="30992" checksum="2B2ABBFA7AF71FE9" modified="2018-06-20" version="1" fragment="single">MADPISIVISAASGTVKAAIGGFQALDKLSPEHRIKAGDLYLQQTADLKLKHIDMLTVDALEEHRHSLTEVEQIRMQYDVVRRKGSKFTYFREMKLSRKFEKKCAQVYGATIAWTTNCVNDHIERSLKVRKEVPACNPSVGESDEDMDKPYKGCHVRVNFSDMPDRTVDVYANGEKGVHVSGKNVEWQACTYSCKHGTMLESFPEAPSTEANEIGADYVPQRGPSPSLSRRPSPLASGAKASSNYDDPGRNPLAGVNSPSEPGSSEPIAEGSGGFVMHMNQCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBX4</accession>
    <name>A0A2R6PBX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBX4"/>
    <dbReference type="STRING" id="98765.A0A2R6PBX4"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="236"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR88735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="35484" checksum="A558E531561EDE8A" modified="2018-06-20" version="1">MPPKKAAAQEKKTLLGRPGNNLKIGIGASTGAGLGNAFLSHVRAVDGIFQVVRAFDDADVIHVEGDVNPIRDMEIIQTELRLKDIEWVEKHLDNLKKGGRALGNNSLADKAKKEEIATVEKVLKCVSVDNKDVRKAEWTNKEIDVVNGLQMLTAKPVTYLVNLSEKDYIRKKNKWLAKIKAWIDEKNPGDPLIPFSVALEERLANLSDEEQAEEEKNIGTQSALGKITQAGYASLDLIRYFTCGPVEVRAWTIRRGTKAPQAAGVIHSDFENKFVCGEIMSYEDLKEHGSETAVKAAGKLRQQGKPYEMVDGDIAYWKSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC44</accession>
    <name>A0A2R6PC44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC44"/>
    <dbReference type="STRING" id="98765.A0A2R6PC44"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00317">
        <property type="entry name" value="cyclophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR88743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="29918" checksum="79BFB39E75E4AC9D" modified="2018-06-20" version="1">MAPEESRYTAAPSQMKIYRVLWILKGIFSIYLLVSLTQFHARLLCMANRGPDTNGSQFFITLRACPHLNGKHVVFGKVIRGYSEVVEKIAQVPVDEKDRPAVPVTISNCGELMLRSKKTDVPPPARVKAISSSESQDESDTSERHRKKRSRHRSRSSGHNSDEESGRRRSKKHKHKQSHLPPPNSEKKGNHTAESVTEEETEEQYDARLEREEKERLELQRKEELRRLKSMQETMTVSNGVRFKGRGRMKYIDPELRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC81</accession>
    <name>A0A2R6PC81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">High affinity uptake of sulfate into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC81"/>
    <dbReference type="STRING" id="98765.A0A2R6PC81"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902434">
        <property type="term" value="P:sulfate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000046">
        <property type="entry name" value="Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="529"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="770" mass="84568" checksum="ADC5F1469414F5C7" modified="2018-06-20" version="1">MSVAAKVKNYVKKAINYPDDEVPVITAKDWVKSLSSDPVRDFVSYVTSLFPILGWIYRYNLGWAYGDMVAGLTVGIVAVPQSMSYAQIATLPAEYGLYSSFVGVLVYVFFATSKDVSIGPVAVMSLTVSQIIKHVNDAHPGVWDGPQIATTVAFICGFIVLGIGLLRLGWLVEFIPAPAVSGFMTGSAINIVSGQVPGLMGLTGFDTRAATYKVIINSLKFLPHTKLDAAFGLTGLVSLYIIRIVCDRLSKRYPKRARLFFFISVFRNAFIIIVLTFASWLYCRHRVSKSGKYPIKILQTVPRGFKHLGQPTIDPELVTALASELPIATIILFLEHIAISKSFGRVNGYKINPNQELIAIGVTNTIGTLFGAYPATGSFSRSALQSKSGVRTPASGLFSAVVVVVALYGLTPAFFWIPSAALSAVIIHAVADLVASPAQVFSYWRISPIEFIIWLAAVMVTIFATIEDGIYMSVAASLVVLLVRLARPRGNFLGKLTIHNEADSREVFVPLKPNGKIMNPHLKVFPPAPGVVVYRYEESFLYPNCSLLNDAVVDYVKEHTRRGKDMTNVQASDRPWNDPGRKDEALNSSSKPLLRAVVLDFSAISHIDTTGIQALVDTRNEVERWADRTIEFHFSSILSPWIRRSLVAAGFGRGDSTSPIRHEVAPVTRFHDDFIADPEHVDKDRQKQTAQAHRLPDPEEIITEVRPSSSRTSSEFTYEGPEESPPKSTARLVHAITPFFHFDLAAAVRAAETGLARETSSYGTFDDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGL2</accession>
    <name>A0A2R6PGL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000496">
        <property type="protein sequence ID" value="PSR90428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGL2"/>
    <dbReference type="STRING" id="98765.A0A2R6PGL2"/>
    <dbReference type="OrthoDB" id="2801423at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="471"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR90428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120500" checksum="852CB6CBB6D43795" modified="2018-06-20" version="1">MDDDTNETGGNMLHTTGQIGGVYTPQQVHTPGKAPVLPSSSSSELSGTSQPVTPIYSNPVYMSSMHTPMTPTPTQIPFYLDSAMSEPSIFVSNPLVPFSPATAPPMRDREPRLHGKRSATDFELTQTPEPVSKTKRIQRTAEQKLDLILQAIRDLNWSLSEFLYTLFHVRDTDGQDVSRTLSHARTVSRFLTGNSKYSLGEILQHIQKDPCGKPSEYTPEASMMYSHCVPFHTIRHARPSITSFAVQICREKMLKERNQAVKGASGLHGGASSTSRTGGRRMLCWDDIGQHTAAKVKEIIQIHQPVTWHIIESLVTPKPRKINGVVSVRRKSRPPEVVAVELIASINFARTSHARLLPAARTILYFACGAQETLFKYSSRIGHTTSWKTAYRTLKRLGDQRASELLLLGQDLERGVFARVDNVQRYFKQWEQRLGRENAMKIGIAGTVAEAEDYRPEAADLDKIREKIAQNQRSEVTVENLLSLIDMDNYKLVATLQWLQALVSNVPQLKHLKSDIAKLYRTDAAKNLLPRTQKTKLYPLKTSAKNEALTTDLRDALVDFLGQLGQREESYTPRVVWIGGDGMTYEKMLNLKKFLQLQDNSFNRFDIIKPFLENWHTGWTQLCLTYETHWGDSLTKDPSKIGHSATKIGQKGPTNVKKVDYYPSIYLSYTILDARMVDCWRIYFGCDDIHEYFNRLEIDDKLPTFSELKEIARTLNRRYGSLQGYYAALRSNAFSEDPIMQVPDGSPWKPQSAESALASAPSKNPADMYRGDQCLAHSMMFIHDTIISREMTMAVAEGDSGRVYEMMKMMLFMFAGSNHSKYLAYTLEQVCDLEYECTEAMRDVFMRNWLINPSGTAGGYKEGDIHQEHYNLELESMMGHKDTEWDSTLSRDIISPNVDKLIELKNTFTDGVGLARRRKKHTSPHSNPEMKILLRTYKETELHSFRIGRCYTSADAMDIDTFGRGVKALLKDKLQKWIHRTTKVCVLNHGTSQGELHVAIDEDDGNDADDNDNEGTTENITNGAIHIVNGELIIEVDPEVDEQEGSDEEPMEDEDVEEDCDGDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMU4</accession>
    <name>A0A2R6PMU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMU4"/>
    <dbReference type="OrthoDB" id="2804738at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="202" mass="21399" checksum="C0F80E647D1C11A1" modified="2018-06-20" version="1">MFSVLRTILAPQVEAVPEAGILSSEQLLASSDAASNECLSISVSLSEPQSEDQTLETKGVLQRSARVVTLENQPVISDTTLGVLDSKSLKPVTGSSPVVVVVGNENTQPISTHAPSGDGLHRTEPVTSFSQQSIKAVQAPSSPRIDQLCKSAANRRDFQEYEEGQGVLRIQAGKIEPLGIPVPSTYADATNVSDTELYARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PP99</accession>
    <name>A0A2R6PP99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000450">
        <property type="protein sequence ID" value="PSR94462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PP99"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="18553" checksum="C04F963BA0DC7376" modified="2018-06-20" version="1">MVRGRLNSILKVLDIQPQLIIILYGIDHTHSSYPLPSLTDLLTAVAAATRSIRAQVNERDLDRDSSASWTRAAPSVEWTLERTFEGCLCTLVFLRDAVRKLQTTADRGVEQLRTQRRELDVANSKIADEQRQKEVYRMNWAHAKMRCDELEDWLEQAGKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PV90</accession>
    <name>A0A2R6PV90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PV90"/>
    <dbReference type="STRING" id="98765.A0A2R6PV90"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR97095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="403" mass="44495" checksum="186012DFB0147D41" modified="2018-06-20" version="1">MSRVRSENQVREEKAAVPPENGGDFEKWSDINEFRTVDDRTNIGNAKILNSATDDSLVQTLHISNQQYLVALMIFIVAYTIFETPSNYMLKKFRPGRWLAMLMLGWGLMTMVLGAVHNFAGLVAARFFLGVFEAGLFPGMVYCLTFWYKPEERALRIAWISASAALGSAFGGAIAFGVGRMNGVKGLEAWRWLFIIEGAPSCACSILVFLFFPDFPETVKWLSDEERELAVERIRGVASLGHAKITWKEARETLTDWRLYLHYLIFMSIDVPFASISLFAPTIISGLGYEGLNAQLFTVPPYAIAFVVTLLLAWQTDKHNVRAWGIVLALGIAGVSFLVQGALPLDAFKARYGLLCVSVSFAFASVAPVLSWLTANLRSTGATTLAVPLNISTGQFGQIIGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVR5</accession>
    <name>A0A2R6PVR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v4273</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000431">
        <property type="protein sequence ID" value="PSR97715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVR5"/>
    <dbReference type="STRING" id="98765.A0A2R6PVR5"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR97715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12607" checksum="C6B93B2CF7BA7FDB" modified="2018-06-20" version="1">MHKVTEDDVYRGYHIPGGSTVIANSWAILHDPATYPDPDKFSPEQFLTDTGELNLDAPEPTAAFGFGRRICPGMYMASDSLWIAAASLLWAFRVEKPEGGEQESPTGNYTSGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYX4</accession>
    <name>A0A2R6PYX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYX4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="8067" checksum="780B7B094A1AA9DA" modified="2018-06-20" version="1">MVSKKGPRYADEDVHTAMHAEDLVVNYDRESQIIEHIGEISPHMWRTILPHTLRVEPIGLGADKSDYRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2T1</accession>
    <name>A0A2R6Q2T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000402">
        <property type="protein sequence ID" value="PSS01021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2T1"/>
    <dbReference type="STRING" id="98765.A0A2R6Q2T1"/>
    <dbReference type="OrthoDB" id="3262547at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS01021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="381" mass="41145" checksum="0F26E75FC7BBA265" modified="2018-06-20" version="1">MPRYSDQAERIIEQLAAVRDNITVLNEQLKQVIISQKEALLHKQRQSKAGSHSRPAPKPAHSSPDAQEETFWNTPGAAARTLHFTGDLLADEEMDLSAFASPLPVQQPRARPRHATSSRAMQFTSKRLVRDDSLTEFSAADEGVGNAETGSAVEEDTNVNVEPDFELDPAMPEGDDDDDDTDDKTVVLTTTSPVAMMETHSTELDRQIQVSTVCSGDPQFNGPEQAKHVKARTKVTTEVERIVAKIWSTVGDVIMPGHPYDASGSSSSRPPRAKETIAHLQSISTQIASAGSPSASSLSSLSTLQPTAGQPTAQQILTAQMLLTLLNHPPSYSLPLNRLKEILAEGPGAGQSVTRPIYGCVAKRLLKIDRGGGEQVVRFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBL9</accession>
    <name>A0A2R6QBL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000367">
        <property type="protein sequence ID" value="PSS05533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBL9"/>
    <dbReference type="OrthoDB" id="3267106at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015355331" evidence="2">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="185" mass="17947" checksum="A4A8C8880CE3C215" modified="2018-06-20" version="1">MLVLPLPLLLLVWPVSLALAQTSSSISSGSLSASLSSGLSSAVNPSASSAPSSSATAISSTAFPDLGGFSVCGCVTSQCPGDLASAENVSQLFCNVASPSVSLSFSPLPSSTSSSSGVSSSPSSSSSVSSTAPISTTASSSSTPSQTGNTNPSSGAGMTFQQLSYLNIAVSLGLALAALETILRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEI2</accession>
    <name>A0A2R6QEI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEI2"/>
    <dbReference type="STRING" id="98765.A0A2R6QEI2"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="717" mass="77833" checksum="B5B7507517FD20C4" modified="2018-06-20" version="1">MSDRGYFNLLSHLTRSRPSLSLSTFQASIAHYLAHVQPSSTPLAASVVSSPYFRPISYVKLEAISTAFRHAVHLKVKLLKEEQSTLFSCGLTGRTREWVRDVLRGLQGGNALLRLACTGGMLLGLNDLEREFFAPDTHIRRGVEEEIVVSLAEVMDLYCFATSGWEKEFVPTAQGTEGILPIAFLVASRSLHLVASHRLKTLPLSTLATLLVSTIESAFQSGAFLSSLSEAISSDTSARISIKSESSFAQNLRALTASPVISSMASLSGMCAQVLSALSDLNAADAWTAISETMETLNALTTTLEADWLRSPLAALSDEESISPESQELASTMWAILKTLLFTTIRLAQTTLSIVAYTPSSPPTSKAGASPFSLSLTVLHIFSHLSFVLPQFGGVASTSEGGFVELKKVFYTALDILSSDASESSRFVHELHDSFISNDGRSRVPSSSWPERFLQAKKAYVLDCVEQLVPVLSDESIRDDLYPLCELHLNDAAHRETFESAHSVMLAVFASHAQKSGVIRQDGALLQHRFAFAEQCKQPIIVKAPAVLKDTSQNSADGKLNVTQLCLAYRALVRSAGAFGNTAIGQTASEPSEGEAYASFCIDALLHALRSDVRDEHRHRLSLALISAVPSVSLILLPHLLKEVLDVVIEAEDGRRQELVDALFEEIADRVGDDGKQYAMRWWHQNKARLAGVGISESGGTSVVEGKGKARELVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIS6</accession>
    <name>A0A2R6QIS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000340">
        <property type="protein sequence ID" value="PSS08881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIS6"/>
    <dbReference type="STRING" id="98765.A0A2R6QIS6"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS08881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="648" mass="66511" checksum="E66A9FC4B1BF950C" modified="2018-06-20" version="1">MSAFGSFGGNQGTNAFGSFGNTIQQPQQQPQQQQQPSGNLFGGFGSTPTAGGATNQQNAGGGSLFGASTTTQNAGNTGGGLFGGGQTQAGGGLFGNTSITTQQPNGGLFGNSSNNQQQPGGGLFGSTQQIQQPTGGLFGNTGPTNATNTSGTPSGGLFGGAAPAQNPPGGGLFGSTNAGATGGGGLFGSTAGSSTNAGGGLFGSTSNNANTNAGGGLFGNASNTNTNTGGGLFGSTTNTSNNTGGGLFGNTGNTSNTGAGGGLFGNTSTNAAGNSLFANPSASNTGTGNYAGNWGSGNTGGGIFGNTQTQKPVGSLTGQPAQQQPQQGSLFASSSQPAGAQNGSFFSSSALLGSTTNNLFASKANTIPNQQQPDPQSQFAGLVHRIETVKQAWDPNSPQCRFQHYFYNLVDPAQVHLYGRPANATNDALWQKAQRENPDPSCLVPVLANGLDDLQQRVDAQTKQAADHQERLKELKTRIEGLSQRHQLSNTSRLRIASALQTQLTHRVLRVVQHLHLLIPALRSSSIRPEEETLRAALEDLDEEIRRPGGIGKMRGKLNELWALVDAVRAARERDRQDGQVEWAVVDEDGLSQIAQILAEEQAGLAHVTKILQRDIKDLSVIQGIPVKEEEPDVFMGSASALRSSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM90</accession>
    <name>A0A2R6QM90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pheromone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v3343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM90"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004933">
        <property type="term" value="F:mating-type a-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001546">
        <property type="entry name" value="GPCR_Pheromne_A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00900">
        <property type="entry name" value="PHEROMONEAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS11047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44337" checksum="B5D014C3BB96F1B8" modified="2018-06-20" version="1">MHPELPYIAFLAAALVLVPLPWHWRAGNVATLSMIFWLFLVDVIYGVDAVVWANNVEIVVPVWCDITTKVIVGANFALPAACMCVCVHLAQVASVSQVRTSINAKRRRQIIEFIFCYLLPAIWMALHYIVQGHRFDIIEVYGCRATNYVSLPAIFLMWFPPLLMSVIASIFASIALVSFVRRRLTFAKHLESNDCGLNLSRYMRLISMTFIQMVISVIATTSTMVFSIKNGYRPWTNWADVHWDFSRIDQYPIVLLPPFYQNFYYAIWWIIPASSFIFFIFFAFGQEAMKEYRGCATWVRRSLHLHSHSSSRSQVSSTGPLTPGPFTPGPFSPLSRKRSSGIQLTISSPISSASTDGFLTSPYLKDSKDFPTDISQVDVFCYIPPAVHLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXI9</accession>
    <name>A0A2R6QXI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000300">
        <property type="protein sequence ID" value="PSS16474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXI9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS16474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="6039" checksum="726A01C5D53C8552" modified="2018-06-20" version="1">MTLIRASGGMWEVTTGSAGEAVLELYSEDKIRGDCKMQLSETPCTFIFKWLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7D7</accession>
    <name>A0A2R6R7D7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7D7"/>
    <dbReference type="STRING" id="98765.A0A2R6R7D7"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="179"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS22652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="271" mass="29427" checksum="EF0118738743EB82" modified="2018-06-20" version="1">MPEEVVLLVEKQLAVLIDDPHAHHRPLSSQLEKWNAERIGGIQAQIAASEVKEAQDQAASRSMSEAAIRKRKEREEKRAAAARAKALAEGNDPNSAAESIFTPTPTPSSQTPNTQSPNTHVLSGTVGIAPHAVYTVTVPGSSAAELEWYSSHGCAYSTIEDAKAAGIWSYPTNLFERAKCGVFQDLWESGHFMGGGIKFGGDFLVYPGDPLRYHSHFVASVIESPIATLKPMEIVAHGRLGTATKKAHLLCGWDDEKREVSYYSIEWAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM99</accession>
    <name>A0A2R6RM99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM99"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="169" mass="19955" checksum="B5BAA9EC6F1C8065" modified="2018-06-20" version="1">MPTVQYLAGWLFRDDIFREWWNARHPQSDENHLEEDDLSCIMLEKHIAKEFQSTNKFVYTAEVFCLGPKDAQQLYILLMTNNRTWDGIPWAEVPLPHFSSDQPHAMEVKEFMEKDGFDFKKYDVKFLVSREPERILTHRAPTSLKWKLLIWTVFQTAQVVTLTTTAACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPM9</accession>
    <name>A0A2R6RPM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000212">
        <property type="protein sequence ID" value="PSS31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPM9"/>
    <dbReference type="STRING" id="98765.A0A2R6RPM9"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="474" mass="51900" checksum="B2A17B3CB4296DD3" modified="2018-06-20" version="1">MASDRREYISDLKVKYGESSGEAPLNALRELSGLSNNINHRCGGKHVWLIPTYTTDSGAAATSFHIVVQTHSDSKMDDLAKGAGGGYRYIFSKADPDIPRKITHALLLRSNGSISTAPLGWDLITVDINKGRRKSYLYILAKTVATETSSKAFLNVPSVGGYLTVRSNTPKQYVQALNVCYGDDLSELPADCVGELNGLSADVNFQCGGKFTWLVPSYTPDAAKAATSFDVLFLNTEDPKMDDLAKGAGGDFRYIVARSDRKVGDKITQVMLFRSETSTSAPPVSWNGITTPDLNQGRQKGYLYLIWKTVSTNSWSFVSLASISSYISTSNTNQFIKSLKVCYGDDTSEMPIDVVHECSGQSSDINHQYGGKYVWLVPEYTNDPNIAASAFEVSVQTIAQSGYDDLAKGAGGDFRYLIPKCNTQARAKIREIELLRSAEVIVTPPVGWDGMTKNINIGRQKTFLYVLWKNAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPW9</accession>
    <name>A0A2R6RPW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000201">
        <property type="protein sequence ID" value="PSS32071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPW9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="137" mass="16085" checksum="99D39C9F1619ECF9" modified="2018-06-20" version="1">MYFGWKIDADKWFEYAKLHDLTVVTRVCYFEGEDDSDFSDNENGDIPEIVEEEVDKLFSVAEVCWSFLWELKITPYTACPLKCSMSLRGGVTMLALRDNYKDNSSLTQDKLQQLQDKLGETGPPKWYPSNHFHWTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ97</accession>
    <name>A0A2R6RQ97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000185">
        <property type="protein sequence ID" value="PSS32211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ97"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="239" mass="26872" checksum="4BF40F3F3315D1E1" modified="2018-06-20" version="1">MLYRPIGEDGDSENDKPLLQRIGKRKRKNKGERKGKNKVALGVTRQAVDPGQGTGRIRVGYSQYILAEGYVDDTGSSIVLEPPSITDLGEHHNDNVVPIQTRADTRHPDQVGSLLSPDCLEQGDSRQEAIEELERFLGREAEAKKGMKLARRPLGMTARSSVDWVWKASRVKTMRKRLVETIHQLSCAEDFWPCELAYPSAEDLDFNYPSTEVLGDRDEFTLQETDSEEEIPNTDTDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQA1</accession>
    <name>A0A2R6RQA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000186">
        <property type="protein sequence ID" value="PSS32205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQA1"/>
    <dbReference type="STRING" id="98765.A0A2R6RQA1"/>
    <dbReference type="OrthoDB" id="3232438at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="243" mass="27265" checksum="B87EF1AFD6E9041B" modified="2018-06-20" version="1">MFHYLEAIEQKGALDGYNTELAERLHIDFAKEGYRAGNHRDYIANMTKWLQRQEAANLRKDYLDWLHQEEAAAAASLKKKVGSCAHGLPVGDESDGEENMTSKRPDLRFLPSQIPRLYRIAIKCPSPRTALRVLERAHGASEFLPALTTFLKRHFPQATSLPSRLTHYNTYKQVKVELPWNRYITSAVCIDKIRATAAVPARGQSQAVPQHLDTAIVVEDRAAYKAGSKGSLDGECIFMKAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVQ0</accession>
    <name>A0A2R6RVQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000154">
        <property type="protein sequence ID" value="PSS34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVQ0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6046" checksum="0C6EA96D257576F9" modified="2018-06-20" version="1">MCGPGLKAIRPGLPGPSDRAKAKPSGRPMGAHGLALPEAKPGQAAEPRLVCLNLVGKHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVX7</accession>
    <name>A0A2R6RVX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000149">
        <property type="protein sequence ID" value="PSS34150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVX7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="6326" checksum="B0913A8C0FDA3BDB" modified="2018-06-20" version="1">MPPDSRRPVKTEKRKAREEEQCVGGHIDIILEDWNADKEVERPSPNFCVLMDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZX7</accession>
    <name>A0A2R6RZX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1481</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000116">
        <property type="protein sequence ID" value="PSS35570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZX7"/>
    <dbReference type="STRING" id="98765.A0A2R6RZX7"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS35570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="711" mass="77952" checksum="815BE0385840E681" modified="2018-06-20" version="1">MSAYVFPPLPSPIPVTLRGGQTPYYMSPELMQEKAYDSKSDIWSLGCLIYELCALRPPFHEAKTHAELSILIRNGRIPPLPKGYSPTLSSVIKAMLNLNPAMRPSATQLLQHERLDLAFKVSETQKMLTAVKTHKAAVLAKERDVTAREAVLLEKENHLTSLLSQKDDEIASLRSLISTAESKHHAAVREALLRREEELRAMVLKQEEDVRMRMTKREEEIMEAVARREEEIGRMWAQWELETRERMATAVDERITWVQERTAELEREQTRLESTRSELERRMEQMEAAAASTAADRRVSVSVGNSGHRMKTPLEEVKNILAPLTRLTDPIDPQQTPVRPAKSRMMPEFQTPMNRAAAPLDYAMPSAMKGVILTETGEKLATPSPAEVAKLFIATPKVSLNFAQIFDFDSESEAEEGVQGLGLDGLESDSADESGYETDTRVPPSIQSSTSSGSRESLKLRGSKGSRERLDRTVRVTVSRETVEKGSDEEEGDVDVESTPRQAVRPTRLRRPSIRASTSRPLLETTASSSSSAAAACSSAKPSTSRSKSRPRPSPVISQPPTAAAVPSNPQPAPQRTGRVEYDLSDEENLPSPFLKKIERERITRTASVPAPIALQLVAAQQRQPPPETSAPKPRAVPRKSQTLRAMAVVNSANGVGGSGTMSRTVGGLAKASGAGTAPGMSRAISTGGVRPSIAKAKLATEEARKTLFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3Y7</accession>
    <name>A0A2R6S3Y7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3Y7"/>
    <dbReference type="STRING" id="98765.A0A2R6S3Y7"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS36965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="385" mass="42793" checksum="266EC3A5169C979C" modified="2018-06-20" version="1">MHILEAGDPSGPLIVLLHGFPELSYSWRKVMVPLSNAGYRVVAPDQRGYGRTKSCFAGDSPIQFNDDLSPFRILNLVHDIIALVYALGCTSVLTVVGHDFGSLVASHCALIRPDLFKSLVCMSAPYPGPPSLPFNTENQSTPSVHQASPSVTLDRFLRSLDPPKKHYTAYLSGPDAGKDMHDPPEGLHDFVRAYFHVKSGDWPVNNPHPLGGVSELTKLPHYYIMPAGSSMPEAIRQDAPSKEEAVLQNLWLPEEDLDVFVEEFGRNGFQGGLNWYRAMTDEQLTVDLSLFAGKKIDVPAMFLGGAKDWGVYQSPGALEKMHLCCTRMRGEDVILVEGTGHWVQQERPEEVSRHLLHFIETAKSVRRFRRIPIQGSEAHISLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S405</accession>
    <name>A0A2R6S405_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000087">
        <property type="protein sequence ID" value="PSS37024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S405"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="208" mass="23031" checksum="4435EC55DAB8E24E" modified="2018-06-20" version="1">MQDLSDNQPLLSNMEATLLALCSAQHNGLVPLKIQQVDKALLDAWYAQVPPITPHNMTKDALIAMKRIPWNNSKYCSDLEDIVYVYIWNKEKPPSLPTPHLLNTVPLPSPLQSTSALRLSKLTSPSPLPSIAPPTSSTLLNPDPLLAILREHAASARSDATTKRNKARVADLKATISKHKARAYEKAALENNIDFTQRQDHPDAHLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4G6</accession>
    <name>A0A2R6S4G6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydroorotate oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000079">
        <property type="protein sequence ID" value="PSS37184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4G6"/>
    <dbReference type="STRING" id="98765.A0A2R6S4G6"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="3"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="350" mass="36922" checksum="9EA3D19A5B452480" modified="2018-06-20" version="1">MVQVHTIEISPPLINASCAWASDLAQLRELYDCPYTGAVTTRTATLNGFGEDDSNTVVFAASSTSSLNSYGYSPHPLASYLSWVHTLLTTPTASGSTPSKPIIISITAASSTVLGEMLDEIQELRVRLKQIHHSNGAAGVIDPSTLVAVELNTSCPNIKGTSPPAYNFPLLLPLLDVLASTFRSDSSLTIGLKLPPYLYSTRFQEVVRDLSMYSRGVPGSEGQDTANPFAFITSTNTLGSSLFFADQTTLPSSATSSDNAPYALPTQLGGLGGEALHPLALGNVFSFAKLLGAHSDPAMRRVVIFGVGGVTSSEAVRRMYGAGAKIVGCATMLGLMGVKVFRYLTDDASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4H3</accession>
    <name>A0A2R6S4H3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000079">
        <property type="protein sequence ID" value="PSS37194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4H3"/>
    <dbReference type="STRING" id="98765.A0A2R6S4H3"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="553" mass="61567" checksum="5EE85A7CB3DF8FD6" modified="2018-06-20" version="1">MKSLSLKETLLPQPPSFQKKKCYEIHQVLGTGTFGKVMRATWHVPPGQVPVAQHGASAPLPSPPINGSTSSTSRTLTHSSSTKSANSSGRLSLPSLSRTPSKDGLSDSGMTIEVALKVIPKKKVKGNEDSVWGEMDVLKGLDHNNIVKFYEWFESRSKYYLAFELAMGGELFERITQKGKFTESDAVSVVVSILSGVRYLHEHDIVHRDLKPENILYRTKDSDSDIVIADFGIAKHLHSPEEQLHSLAGSFGYVAPEVLNKSGHGKAVDMWSTGIITYVLLCGYSPFRSDDVKELIRETTEAKIEFHERYWKNISQEAKDFILALLNPDPTKRLTADEAIRHRWLTSHQASTEHDLTGLRDNFNPRARWKAAIAGARALHRFGSSQSRLTQSSTKSSGGWKDSDDDDDDDDDVSAPVSVANGRAEDGPGENEFVKVIGPKDDLPPASSPPSTDSPQTSHESREEFSKNKPTEAHGLKREDDTHEPLHQNIPKELHDVQQESKDPPEPVDGDHVQDDTDDELNIPGSFRVRKEDQQHHHLPGWIDLFRKLHVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4J8</accession>
    <name>A0A2R6S4J8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000072">
        <property type="protein sequence ID" value="PSS37220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4J8"/>
    <dbReference type="STRING" id="98765.A0A2R6S4J8"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="317" mass="37392" checksum="F818B18EC1322872" modified="2018-06-20" version="1">MKDVSLVVAYKLVIYLADFLEDVFWSQNQAQLKDPDSEEASEVDHWDDETIWKKYCEAVRSQQGLAESIDGYGQIQIFRITDKVIVKQTLGRTFDDAVQVPHEALAMEFVRKHTSIPVPRILRTIHNKGTEGELFYAMDFVDGQQLRHVWPTLSIWGKLRVAWTLRSYIRQLRRINSTLSSVPGPLGDKPQTCIGFIFEGKRQTSFPSMEALFAWFHGIINMRRTRARLPPTEYDPFHDCKRMVMTHMDLNMRNILVGKDSRIWIIDWDWSGFYPEWFEYVSMFYAEKFTNGPVSWMRCIPFVTDPYIKRRRWLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4L9</accession>
    <name>A0A2R6S4L9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000072">
        <property type="protein sequence ID" value="PSS37216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4L9"/>
    <dbReference type="STRING" id="98765.A0A2R6S4L9"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="37809" checksum="A837147332FBC76A" modified="2018-06-20" version="1">MNTQTIPRNPFKEIPIVIAYKLLICVADFLEDVFWARNKRELEPESKEASEVDLWDDATILDKFYGAVRAGQGLPESVDGFSELKIYKISESIVVKQAMGRTFDSPVQVPHEALALEFVRKHTSIPVPRIHRILHTETEPGTHLYVMDFIEGDQLGQVWPTLLPQWGKLRIAWTLRSYIRQLRRAKSTLSSVPGPLGDEPQTCIGFIFQGKRRVSFPDLPSLSSWFHAGVRATRERFGLPPSRRDPFRKCQKMVLTHMDLNMRNILVGKDGRIWAIDWDWAGFYPEWFEYMNLSFVSMMSTPISSQRCIPFITDPYVECIRWMQATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5H6</accession>
    <name>A0A2R6S5H6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000038">
        <property type="protein sequence ID" value="PSS37534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5H6"/>
    <dbReference type="OrthoDB" id="2562239at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6294" checksum="71B8EA192B6A7427" modified="2018-06-20" version="1">MGFQTTSILAGPLNGARSKVFFYVFQVAPEWLACAVLLSVNVREMFGTGLWGDLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6F2</accession>
    <name>A0A2R6S6F2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6F2"/>
    <dbReference type="OrthoDB" id="2757830at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015360172" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52473" checksum="906C5117740202C9" modified="2018-06-20" version="1">MMLLNFDILIHLMGWITARRGVWLLMQTCRTLKSAGMPRLFRSPVMLYDHKQFAAFCRFMDASGSTCTRFLRHLMVQTPLLVRAQETGTLKSFVSMLEHAQQLQKLTIGHLADEAQALDPSLLQALTALTGVKDLTISPDASAFIPMLQSLRSPVVKMEINFKRVPVQVAPMSIIQNFSSSLEQLKIAWYPDLFAPDHGAQFPRMTELDIMCMGFLAVDTLIYSFPNLRVLRANSYNLRQLASSPADGEAQRQTNLSSQSRRRWESLDRLEGPLEYLFMLGISCDVGHLSLTLTEYPYDILGADLITAILSATRPKQLSVYMSCNSSKLRYYQIPLDLASEELTHLTLNVAVDIDGNVEMDALEIIEDMVSLLYFLPRLSHLVLRLTWWIEDQNDPASQLFLREVDLEELATEICGVAPVINHIVLEMSTEMRCVYEVVRDEDGEGTLTKLTGEAARKVQGDGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Q0</accession>
    <name>A0A2R6S6Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000015">
        <property type="protein sequence ID" value="PSS37964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Q0"/>
    <dbReference type="STRING" id="98765.A0A2R6S6Q0"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="203"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="732" mass="80369" checksum="E4E97CA7D2C61323" modified="2018-06-20" version="1">MHTEDGRSIKAVAKEKEQARREHERAIRHGRMTGLVEHTTDDIFTISLGSLPSLQMITTKLTYVLDLMDNDLPDQVRLQLPVCIGMRFGTLPEGMVQAKTIPPERISLTTEVYMKGAIQSITSPSHSTLTLLPDGDTHKTTSVPSRVAEYRSPTFLSQDFILAIQAEGLDAPRCFAQRGPDGSVAMQLTVVPKFNLPTVSAQEYIFVVDRSASMAGARIEQAKRALVMLLRALPRQGTVFNIFSFGYRCDSLWGESRIYNAETLETATFHIDRMNADYGGTSIRSALEKVLSSSDTQLPTACFVLTDGEAYDINATIDVVTKAAAGAQTGSPLRVFTLGIGETTSSAMCEGIARAGNGVCLMAAASESIIAKCSKLVWASRTGILENVSVDWGVPQSALDSNSADDTQTTVLRQGPSKVSSIYTANRFVVLAIVESGTFDIPKEVVLRAQRHSGQIFTFAVPVEVLSNTAQEPQRPLIHTLAARRIIMDLEDIKRGHVSSETKALIIHLGERYQLASRYTSFIAVEGPDQEKLLPVDEESIKAKSDPVQAVESSVDEQEHARRSRSPTRITRTGSPRSPRRIVMTDRHSRSRSPIFVESRQSEGSVSPIRTVRTDTSRSRSPLIIVRTAEIPLQSVDDEVVRLVRLQSFDGSFPADKQLANIVGQEALDEAEKLCVDPVIWATVLAIAYLQKNLAQQPHLLEGLLEKANEFVQQSPDLDFKALLEKANSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEA8</accession>
    <name>A0A2R6NEA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001344">
        <property type="protein sequence ID" value="PSR70619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEA8"/>
    <dbReference type="OrthoDB" id="3269446at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="13876" checksum="46CE667C94D07E45" modified="2018-06-20" version="1">MLNTFPITTAQIVALFMESIFFGIYLVTLGYCLRALLCKKDKLVFKSRREIKWVMLVMALLMAIFATLDVAFGLRHNLDAFVYYQGPGAAAQEFNDITYWVNVMKTVDYVTQTVIEDEAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEB9</accession>
    <name>A0A2R6NEB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001336">
        <property type="protein sequence ID" value="PSR70676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEB9"/>
    <dbReference type="OrthoDB" id="3364707at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="775" mass="83612" checksum="0F568CC3F898FE0E" modified="2018-06-20" version="1">MSKPARPKHSGSSVISIPSDAELTSASSLSPRYQQRFYNLPVGGRPSSSGHVTDSAVASSARTLRVSASRASLHAAAYEAEQVQKSRNVLRRKTSARSNPATPTAATFKAAQTESVNATPRKAGRSPDPPRSSAPRRTASATAEPVSVTRRHRTPPSGLTPAGAVAHAYKQQEQLREELSEVTGWNEYTRGQSLPDRSPLHEEDDEEASGAYYTVFGSTTGKVVAVGTAGDSSWDLTYGTQLGPEEQARLVTKVAAAGGSPATSHSSHGVRSLGRKVSGRFKKPAGSPPQRFAADTVREGWTPYDGRQSFQHDRRPVTPSKTKSSVPSLDEYVEVQASPSSIPSVPNGSTERSPMDREGRSLRAQRSHKPKELEKDEESPGGKLWKLMKRISTGGLRDKYVARDSSPPPVPALPKDFQHLVPSRTTFDIRPSSSHGNGTIPTEMSVMRFMNSRTSMSVVRPSTAPQKSSPRAEAPSSRPSTGARPSTTTRSSSPMSSDIASSRFFNKTHSTRSSISSYGEELPPMPKAVGNHIMSPSELYKLNKDGEDPIKGPRRSKSRPRIRTEEATSPEDNQPRPSLRPPRRSGTGGKSAPSDDALPPSPVIPTFSTLEPINNFSPPSRLSLPTSEFGVMDESTPPRPKRSSRRKAVPSESASSDLLTPISPPMPVTPRTPHSPNLPSISVDVSSLDGSHSSHSHSTARDGAQNVSPSSASSNPRSPLRFRELELSRSRLTEKEKADKWDDLLMRSDQAGGTLHIGETGLMSDNIRFSEYSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEW1</accession>
    <name>A0A2R6NEW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001302">
        <property type="protein sequence ID" value="PSR70924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEW1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="14316" checksum="D2554F2B1B9DFB68" modified="2018-06-20" version="1">MEMRLTERLVDSGETCDLSESVPHCLSGGASNPTDTPNPSSVLSPTDSNSPSVTPSPIFSPSPSLTPSNLPTPPANVSQPSGQNSSTPSNSPSNAAGGSPIPTPPLQTSGSGKVNLQITVMTAGQILFLNGLAGIVLHLSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFM1</accession>
    <name>A0A2R6NFM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHLCEN_2v13027</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NFM1"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="19">
        <location>
            <begin position="38"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="20">
        <location>
            <begin position="775"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="1051"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="955"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1094"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="995"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1020"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1108"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1128"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1180"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1215"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1259"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="131"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PSR71058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1290" mass="141609" checksum="7A6A1661A0C37863" modified="2018-06-20" version="1">MAPSKKAGKKVAAAPKKAGGAAKVAKADWKEGFKKKQVGVSDMTLLTTITNESINENLQKRWTNGEIYTYIGGVLISVNPFRDLGIYTDDVLQRYKGKNRLEVPPHVFGIAESAYYNMNAYHENQCVIISGESGAGKTEAAKRIMQYIAAVSGGQDSSIQEIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIMFNDHGEPIGAQITNYLLEKGRVVGQVESERNFHIFYQFTKAASPEQRETYGIQTPDAYAYTNVSNCLEVPGIDDVQDFDETIRSMQIIGLNDQEQSEIFRMLATVLWLGNIQYTEMDDGNASIADTSITDFVGYLMEVEPSLVQKVMTIRVVETQRGGRRGSVYNVPLNPAQASSTRDALAKAIYNNLFEWIVSKINVSMKPRSTAAQLIGILDIFGFEIFEDNSFEQLCINYVNEKLQQIFIELTLKTEQEEYVREQIKWTPIKYFNNKVVCDLIEERRPPGIFASLNDACATAHADPTAADNSFIQRTSALASNAHFESRGAQFLVKHYAGDVMYNVAGMTDKNKDLLLKDLLDLIGSSGNQFLQGLFPDRPDPNSKKRPPTAGDRIKTSAGALVENLMRAQPSYIRTIKPNQNRSGSEYDTKAVLHQVKYLGLQENIRVRRAGFAYRNTFEKMVERFYLLSPSTSYAGEYTWQGDAKSGCEKILTDTGIAQDEWQMGVSKAFIKNPETLFALETMRDRYWHNMAGRIQRAWRNFMRYKHECARRIQRFWKNNKEGLEYAKIRDYGHQILAGRKERRRFSLISYRRFMGDYLDVNGKSALGEELAAACETSEKVIFSSRIQVLVSKFGRSSKLSPRFLIVTAKTLYILVTTAKDGLAQTAVERKVAVSSIKSVSMSNMRDDWMVFNLGPTEEGDPLISCIFKTELTTHLLTLTQARIQVLIGPTIEYTKKKDKKGTVKFLKDETVVRNDMYKSHTVHVPSGEAPNSQSHPPAKRKEGVVRPITQGKLLRKGGPDQKPAASARPKPAARPLPGKSAPTVVKPPSSVATAASSTSSAPRAPPPPPRAAAPPSEPDVEQYKAKFAFEGQDGEMSLKKDDIVELVEKDDNGWWLVKKGTKEGWAPNNYLELVPPKPKAAPAPPPPPPPPPPGAGARRPPSMTPAAPAAPAAPRAPAAPTGKVMPKSMVADSSAKPVSVFPGMGPSNGSASPWKRTASTATDASSQEATSRPSSSLAGKHAPPPPVASKPKPAPPPVGHKPGAPKVPGKPPVPAASRPPAAVPKPGGGVKPAGAVGGQMDLAAALARRAQRIAEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFW7</accession>
    <name>A0A2R6NFW7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFW7"/>
    <dbReference type="STRING" id="98765.A0A2R6NFW7"/>
    <dbReference type="OrthoDB" id="2750010at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="13952" checksum="02C0AB0C1E4261FE" modified="2018-06-20" version="1">MMKRTFWALMIFERNMSSALGRSCSIQDEDFDLDLPIECDDEYWTNANSALAFTQPAGKPSTVSHFVCCIRITQIHAFALRTIDRRGSLPRLHFRLSLYAPMPPAAVFVSWMCNFGAHRHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHS7</accession>
    <name>A0A2R6NHS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001233">
        <property type="protein sequence ID" value="PSR71909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHS7"/>
    <dbReference type="STRING" id="98765.A0A2R6NHS7"/>
    <dbReference type="OrthoDB" id="3253416at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16940" checksum="981318129E1E2BE7" modified="2018-06-20" version="1">MPRASSSGNNPAAIHQTKFRVLPRKSYSERMSETRAEIRRIVKEALREITQDQNASMRWPSYWKDIVVKYRVVIEGWPHTEVPFRNLSDVSNLQKLELLLRGWQNGEIYFRRLPDEEFELLSAARAAQLEASEEGGGQDGFSFEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI38</accession>
    <name>A0A2R6NI38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI38"/>
    <dbReference type="STRING" id="98765.A0A2R6NI38"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42721" checksum="35EE1C7659E6D0C7" modified="2018-06-20" version="1">MTLNPTIFSLHGKGLKLNTRADIEPYLRDVNPAIVEEIHFGGNTVGIEAAEALAEFLEKTQVLKVADFADIFTGRLITEIPQALSAICDALKNKTSLVEINLSDNAFGGRSVDPMVPFLTTNRSFQILKLNNNGLGPAGGAIIADALLQSAKLSKKEGKPSNLRVVICGRNRLEDGSASVWAEAFREHAGLAVIRMPQNGIRMDGISALVRGISECKGLQYLDLQDNTFGELGSETMSGILGQWPHLHTLNLSDCHLAEEGDVSPVVTALAGGSNLKLQTLQLQNNNFDAQSFALLAEGIDSALGALKRLELQWNEIEEEDEGILALSRALKARRGKLIVDDEEDEEEEEETEETEKEETKEEAKPAQPAQAKSLTDQATDALADLLNKVSIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIB3</accession>
    <name>A0A2R6NIB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIB3"/>
    <dbReference type="STRING" id="98765.A0A2R6NIB3"/>
    <dbReference type="OrthoDB" id="5373615at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039228">
        <property type="entry name" value="SZRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796:SF2">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="150" mass="15510" checksum="E33504402CA613BF" modified="2018-06-20" version="1">MPELVISAGTATSLAALPPPAAFQPSLRILKRPSASPSPSSSAAADSQQKSFAEREAQYQAARDRIFGGTPPSDASNTGRHTVKSRTPPSSTSPKLTSQNPPISNVIRNPRGPDTVSGVFSTAQSTSRGVSRGFRGRRGTRGSTAQGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJT2</accession>
    <name>A0A2R6NJT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJT2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="6995" checksum="7FA6F4D9638A9E0E" modified="2018-06-20" version="1">MAGFSRHFGRPLEVCGKPQGSLDEARQWRGRYMPSGPPHDSELLRSTLDLLLINLAPVHAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKF5</accession>
    <name>A0A2R6NKF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKF5"/>
    <dbReference type="STRING" id="98765.A0A2R6NKF5"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7316" checksum="29C298880D7877D9" modified="2018-06-20" version="1">MSFFGFDEPNSLEDERRKLLQDAAQHEDVAVYTWGEESYDGLGDALQEGGDELNDETFGGGGQVGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKU5</accession>
    <name>A0A2R6NKU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKU5"/>
    <dbReference type="STRING" id="98765.A0A2R6NKU5"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="6">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="163" mass="19204" checksum="71CB7BF2764BAFF5" modified="2018-06-20" version="1">MKEIIYFQAGNFANYIGSHFWNTQEGYFTYGDEAEDPTVNHDISFREGLTAGEPISKSDYHAKLDAEEEALNEKDRDAEDPIQADDSKIRFWSDYNRVYFHPRTIHSLPDLSDWENAEGDWALGRDTFHKFNEDTDFMEESFRPFVEECDSLQVCLIWENFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM23</accession>
    <name>A0A2R6NM23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM23"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="9066" checksum="0D187706A12FA2C6" modified="2018-06-20" version="1">MPGQGRSFTSTEMILLPVWAWFGTRRRRRYEAYGVHGPLGEVWELRSFNETGLRMKRRWCKVVNSWARFAEAKKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NML9</accession>
    <name>A0A2R6NML9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NML9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7493" checksum="9D2B7EAAD691BFE9" modified="2018-06-20" version="1">MPKVEIMGIKYRYRVVGYPEGRMETKRIKPTKRIPASQIVRTANATQIQIIESCVRASCQLQVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMW2</accession>
    <name>A0A2R6NMW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001067">
        <property type="protein sequence ID" value="PSR73724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMW2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMW2"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="6">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="269" mass="29903" checksum="E27B93D08CE0A706" modified="2018-06-20" version="1">MSAKTNTEAKVPVLKGQEGTMNRPFGAVDVAANLKGAVPKTATQKILVTLAEKGELIQKTYGKTTFFVANQANLEDMPAEKLKTLEIEYKAVEETNKALLADVKAASAGIDPDSTSPLFLSYRDLRAGEAEIYTDGRTNLLANGRDYCYGTKCSRVHFSLPSDHPRNWRLSSQIAKAIAHLQPLRSGSPLVSAEELARLDAEWLKWRAEWIRRRKIFNDFWALAIDALPPQDASELAEDLGIEFDTEEHRYLEKGPLCVSGSILGKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN03</accession>
    <name>A0A2R6NN03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Carbamoyl phosphate synthase arginine-specific large chain</fullName>
            <ecNumber evidence="13">6.3.4.16</ecNumber>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PHLCEN_2v10406</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="13"/>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NN03"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="591"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="1129"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1394"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PSR73762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1547" mass="169867" checksum="41847EFA26D8215A" modified="2018-06-20" version="1">MALDKPSSRILIVGAGVFGLSTAEHLLRRGFRCITILDRSEVLPAPDAASCDINKIVRSSYSDIFYSQLAREAIHLWKDESVWGDTYHESGVLVLRKSGNEAYTDQSYHNDIALGAHLEDLTTPDAIRATFPADIKTPSFEGSSGYLNHDGGWAFASQGVSLLMRRVASLGAQILAGKAVIELIKKDGKTNGVKCADGTAYYADLVVLASGSWTPSTFASLDLKGKCLATGQTVATIQLTVEEGDRYRHCPVVLDFGSGFYVFPPNADNVVKFAVHDNGFLHKPNSPDAPSTPRTSLSDGDDGLRIPKTVVKKLRDHLRMIYPELAEKPFSGTRLCWYNDSPDDDWVIGFHPLDPTLMLATAGSGHAYKVFEGLDVGDARMGLLRAAPSWTTRCLPSSRTVQSTRHFHWSPYRLALAPTKPVRAVARSAVGSYGSEEGEHVLNSPSELARKISAKVLPKIPRPDVSKVLIVGSGGLSIGQAGEFDYSGSQALKALREEGVDAVLINPNIATWQTSHELASEVYFLPITADYVAYVLEKERPDGVLLTFGGQSALNVGIELDRMGVLERLGVKVLGTPIRTLEVSEDRDLFVQALKEIDIPAAQSTAVSSVNDALAAAEKIGYPVILRSAFTLGGLGSGFANNADELRDLSAKSLSLSPQVLIERSMKGWKELEYEVVRDAADNTIICCNMENFDPLGTHTGDSIVVAPSQTLPDDEYHMLRSAALKVIRHLGVIGECNIQYALNPTSREYCVIEVNARLSRSSALASKATGYPLAYTAAKIALGHTLPELPNAVTKTTTACFEPSLDYIVTKIPKWDLAKFSSQVNREVGSAMKSVGEVMAIGRTFEESLQKAIRQVDPRWKGFEAYIQPEDLDRALSQPTDMRLFAIAYAMFNKNYTVDQLHDLTKIDKWFLYKIDNIVQTVYALKAAGSLEKVDSELMKRAKCMGFSDSHIADLISSSEDAVRTHRKSFGITPFVKRIDTLAAEYPAHTNYLYTTYNASEHDVEFDEHGTMVLGSGVYRIGSSVEFDWCAVTCARKLREMGKRTIMINYNPETVSTDFDEADRLYFEELGYERVMDIYELEQAQGVIVSVGGQLPQNIALRLKHNGVSVLGTDPEQIDNAEDRHKFSSILDSVGVDQPEWTEVTSLEAAKEFASRVSYPVLIRPSYVLSGAAMNVVFEESDLEYNLSAAASVSPLHPVVITKFIDNAQEIDVDAVAYKGKLLIHAISEHVEPAGVHSGDATLVLPPVSLGNEDMVRLKEIAEKVAAAFEISGPYNMQVIRKPAEDDKEAELKVIECNLRASRSFPFVSKVLGYNFIDYAAAAISGHNVPEPVDPMAEKRDYTAVKVAQFSWTRLGGADPFLGVEMASTGEVASFGKDIHEAYWAALLSTTGFKVPRLNSGVLMGGDITKPEMKTVAKGLIDLGFKLYCSSPVVEQFLNDIPYVSAKRIFFPTRDKRKLREVFDEYEIECVVNLAKSRGKDAVDEDYVARRNAVDFGLPLLNNARCAQLFVESLAKKIPQGGLRPYTEGRIPPEVRSWREFVGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN70</accession>
    <name>A0A2R6NN70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001058">
        <property type="protein sequence ID" value="PSR73839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN70"/>
    <dbReference type="STRING" id="98765.A0A2R6NN70"/>
    <dbReference type="OrthoDB" id="3260348at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="109" mass="11672" checksum="D41120F124C3E0A7" modified="2018-06-20" version="1">MQAKLSNAELAFLAACHSAAAESKAPNEVLSLAAAMQFCGFKSIVGTLWTMDDKDGPVLAEAFYKHMLRNGVGKVNLLDSAQAVHLATKAMRGAGVPFHRWTTFIHLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNR2</accession>
    <name>A0A2R6NNR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNR2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6408" checksum="80C747A52FC486C7" modified="2018-06-20" version="1">MGPVATSGTVDQGRPPGRVVSAILGSMVWDLHAIQCKWIVVDVYEVTRQIWWAVDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP83</accession>
    <name>A0A2R6NP83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP83"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="14044" checksum="2BB785D57BCA2E43" modified="2018-06-20" version="1">MDPTGLAAYILDRLRGTPGRLIANFVLHNHINSLSLAEAPEDLLSSMTKGLSDAAIMEFKEIVGGICTAHRINTGTRRFRPLQDLVEQIQHAPDSVLPNEQPADDWEPPEWDFDEGPDQRNLGGNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPC4</accession>
    <name>A0A2R6NPC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000996">
        <property type="protein sequence ID" value="PSR74315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPC4"/>
    <dbReference type="STRING" id="98765.A0A2R6NPC4"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF6">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015329388" description="Cupin type-1 domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="239"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="446" mass="48279" checksum="6D7E7CFB7BB3D779" modified="2018-06-20" version="1">MWTILLPLFIATLVCAAPAPSQSSSASVAQSTVPYASDDPNPILWGPDTSSIPQAIRGSLGATILGPQDVSLDKQNPDLLAPPKDVMPMATGMYQSVHPQDYANKGSRLSHVRGKHASRSRGNSWAYILKNEGDLWYFPAGVPHSLQATDALPDGAEFLLVTDWMAHVPKEVLAKNFQADISAFDHIPGQELYIFPAGKSVLDDLAKHLNPVVYPSALPQPDSDTPISPQGNVPEPFTFKFSQVQPTQLSGGSVKVVDSTTFKIATGIAAAEVTINPGAMSEGTGRVTLFASSGNSRTYNYQAGDVGYVPPSYGHYVENTGNTTLRFLEIFNTDDNPWFKAHENHIREDTHDSSVSASSSFELLERGSLLNARQNATTIPYADGSTIDWQREEAAERERKRTLQAQRGLRGTIAPILDSSRIWIVIVLTGVGIGVAGAWLDVLVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ40</accession>
    <name>A0A2R6NQ40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001007">
        <property type="protein sequence ID" value="PSR74278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ40"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53081" checksum="C198B2CBD4D4B98F" modified="2018-06-20" version="1">MDDNIKRRIKLTGLPGDTPIKFPPLLYLTVFAAPTTPLAHTATITPPSCSPSMADPLGIITSALHAAHKVYEVVKTIKDAPEEIQSLQDQVELLYSILPRINDFPHRAGESASISLLVAKAEELNSSLDKFLNKTTKISQGKRKVKKLKWWFNADEAKSLTGKLSVFYGALSALHSIESSGHIHTRFSDLEESFTSTNEHLQGCFTEVHTHLDAQLVGVREIFQEELAKSSEELMHSLLASRVRELRTLANEQRRGESHGFDQNSVLYNMDYVEQVADVLSVSQDQADDSSTSARLDHTSSTVAAAAVYYPPPSLSSLETPCKHCGCQCHGAQSLWRTPESLASIIGHHYLKIPFPRRLWPGLIRCDVPTCKKGWLIQVRSFLPYWFARIEMQMRFEMLPVHFCIQTPRVNTDIKWHLGRMVLERGADVFKELLRSRRVTINDVDENGYSLLHVRFNVNLDATTVNQPNDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ46</accession>
    <name>A0A2R6NQ46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000970">
        <property type="protein sequence ID" value="PSR74670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ46"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="9561" checksum="8CE3DFDCC15BB6E9" modified="2018-06-20" version="1">MDNQQDPIIEKIIISARPGQALPGLGGSHILPFTSGSRLHPPALLVRKTTPVYTGHPYPYPPYRLLRSYRPLDFLSSSQEGEAHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQP1</accession>
    <name>A0A2R6NQP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000949">
        <property type="protein sequence ID" value="PSR74874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQP1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10025" checksum="4B120D8E5ED457DE" modified="2018-06-20" version="1">MPVECQLSVEIAKNAREAATTRPTERTNSGRTTVKVLASRPVSERVVVPSSVPNENVQRRLNPSPRLSLLPSPLVRESPSPPPPGNPANGMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR55</accession>
    <name>A0A2R6NR55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketosynthase family 3 (KS3) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000925">
        <property type="protein sequence ID" value="PSR75112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR55"/>
    <dbReference type="STRING" id="98765.A0A2R6NR55"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="3">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="193" mass="20438" checksum="E64555FBBFEFFD93" modified="2018-06-20" version="1">MDLSSDPIAIIGNAFRLPGGIASEDSLWEAFLQHDTSCMTHAPSSRMKFDFPRESIHCDPASFLVGGWLGSNGVEEFDASFFGFSPGEAETLRPNSRLALELAWEALENAGLPPSSLKGQNISVTIAMGAEDGWDIRRFAEDGPAAFDHNWAQNSDPSAVAGLVSRFFDFRGASVTVSGACASGALAMDTGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR74</accession>
    <name>A0A2R6NR74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000921">
        <property type="protein sequence ID" value="PSR75176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR74"/>
    <dbReference type="STRING" id="98765.A0A2R6NR74"/>
    <dbReference type="OrthoDB" id="3147752at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="492" mass="54842" checksum="3975C9B68BA7E2A1" modified="2018-06-20" version="1">MLWRQIMSITGQRDNMDIEEGPSLAERSHGNAVQTGQDATISATEVANGSRDPFDIAQDKIMKVRKENKKLVREKEDLEDQLREVEEESRKRNRKLYGRCKELEAVIMKGTAQYRQLRDRMRRCEGEGKELVEARETIAALRRELHSVHSQQSDKDALLETRTCELRNAQALLDRTDVVSHADAIRMVENLNSEIYQLAALIPDSVNFQKARRTETELTRAAYKGVEMSIGKELVELLATGSVHHGDDPICVQIALQTLLTQFATSIITSWDVRLGKGGNKLLDQIHSKILLNEPLVISAKWRSLTRRYLRHMNPKKEAAPSIEADILGKITDILITSGACGDAQSIHRSVSRTFGAKIKDIVNRSGGVSKAIAEDVASAYFQVIAPHSGVVFSSDCMEDEYGGGRGDAREQSNDKETRTLCTTQVGLRRCETQNTSTGKGGNEFNIVVLLKSKVALESIKQEMMRTEQSNAVECCPIIDVGCCLVRAMLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRE6</accession>
    <name>A0A2R6NRE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000947">
        <property type="protein sequence ID" value="PSR74880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRE6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRE6"/>
    <dbReference type="OrthoDB" id="3194731at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="427" mass="45542" checksum="835AB5305C4C31E8" modified="2018-06-20" version="1" fragment="single">DFSGKSSQEADDFIQAIHKIARDNDRSHDPEWMAELASVAFKGNARRWFNTLTFEQKHDWGKLEEAISQKYPPDPTSDSVPSPSNPAISGPGQIPSSSNPTPGAGQFPPFPTSNPGQFPPSSNPNPGAGQFPSSSNPTPGAGQFPPFPTSNPGQFPPSSNPNPGAGQFPPVPTSNPGQFPPSSNPNPGAGQFPPFPSSNPGQVPPNSNLNPGAGQFPPFSPSNPGQFLPNPNPNPGAGQFLPNSTPIPGTGPFPSNPTPGLGTYPPPPNPTSDSGPNTNPTNDQTKRARLVVNYVGESDTFYFDKYSKNTGPFKLTRKEGDALIVNYTNTDGILVIEAPDFGGNYGTTSQWASHLRFKNGPIISNFSLENGYKLHATWTMGKGPFTLQWLVESQSDVLKTAVGTIDGDALLDVNKQYIQYEEYIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRF4</accession>
    <name>A0A2R6NRF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRF4"/>
    <dbReference type="OrthoDB" id="3252362at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="495" mass="56987" checksum="A2D8CDC220F3BEA2" modified="2018-06-20" version="1">MADSDGEDPPLRDVSRTLAVLATADESPIEFMRACANAGIKPIYEPFWRHLPYADIYLSITPDVLHQLYQGVVKHLVSWIKAAYDPAELDARCRRMPPNHNVRLFTKGITSLSRLTGREHGDICRILLGLIIDMRLPDGLSSGPLVRAVRALMDFVYLAQYPIHSDESLAAMEDALQRFHDNKDTFIVLGIRTDFNLPKLHFLRHYLLFIYRFGTTDNFNTEYTERLHIDFAKEAYRASNRKDEYPQMTLWLERKEKTYPYVTVPFAKAVPFERLAERYGANDFRDCLARFITQHNHPGASRRELEELSALLPFAFRSVSVYHKARFWENTFSLYRHASDDYDVLHVTPSRLDKRGREIPGRFDTALVNDGTGGSLGIKGYRIAQIRVIFTLPPREIPHLFPSGNAPQYLAYVEWFSAFGQPEPNHNMYKVTRSIRNGVREASVIPLTTVHRSAHLYPSFGRSVPEEWTSSNVLDRCSKFFVSSFTDRHVYGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRJ9</accession>
    <name>A0A2R6NRJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRJ9"/>
    <dbReference type="STRING" id="98765.A0A2R6NRJ9"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="18075" checksum="4EA8872252DEE4B9" modified="2018-06-20" version="1">MDIPDSPPPSHHANDSATAFLNPWAAKSLLASRQVFSQFPLALAKRIEGYPIKQVKVITPDFGQSVPEDDVLKATWLGHAVSILSERLSNTISTHLRNRVLQGFMVQLPRVSGLKPVRILFDPIWSERASPHQSAGPRRRLPPPCTIEELPDFQFVVTSHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRQ4</accession>
    <name>A0A2R6NRQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000890">
        <property type="protein sequence ID" value="PSR75489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRQ4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="9079" checksum="7AB53183B117AF12" modified="2018-06-20" version="1" fragment="single">MEDLQDFVNFTDQVPPSVIKQPTEEGFSERSERPRTGSEALQRITATTAAQRLRKVHFLLQHSENILLPNKDQHIINIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRU3</accession>
    <name>A0A2R6NRU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000903">
        <property type="protein sequence ID" value="PSR75415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRU3"/>
    <dbReference type="STRING" id="98765.A0A2R6NRU3"/>
    <dbReference type="OrthoDB" id="2745105at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="128" mass="14235" checksum="EC088D6C4C83BD13" modified="2018-06-20" version="1" fragment="single">PYIYWCLASIAVTDALIAATLCVLLNKYSSAVKRTRNILRMLIVYGISTGALTCLCAILALITYAAFPKTLAFEGLMFLLQNLYLNAVLATLNAREQLRKRYNCCNTIELTPSTPVQVPNKETTVRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSH7</accession>
    <name>A0A2R6NSH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vimentin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000893">
        <property type="protein sequence ID" value="PSR75472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSH7"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18191" checksum="359963FD3648226D" modified="2018-06-20" version="1" fragment="single">MEYDEDVLSFQGKQKTALETFEKREQTLKGLEDALRQKDEELNGEKGILQQLKVELEEREAAIAVREEQLTLLSAFAQIEDANQTLKRLEDIYSCSLLADEIIQQYLNELASVPALPDEDGSTIDQNTSKGKGKGKSLPEDEVMSWREGGSARRDWLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSX9</accession>
    <name>A0A2R6NSX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSX9"/>
    <dbReference type="OrthoDB" id="2535391at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="21180" checksum="169ECA8442C250DD" modified="2018-06-20" version="1">MPPPPLSYGQAAPARQAQSRRHTQENIFSDPTHTVTIPPHLPLNDDRSIRTASIRQSRGNQQTQMPPPPVPGPSRQIQRQHANINASRHPSTPRRGNESEPTFQQRFDEPTALRAISNGGDALSLDTRLQHASSLATQRFMPSTPSGQQRFGTSAPVSVSNKSKFVRSTAVTGLHSSRAAGGQRVPFVPGGQSGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTJ4</accession>
    <name>A0A2R6NTJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000847">
        <property type="protein sequence ID" value="PSR76391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTJ4"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="338" mass="36770" checksum="A6A207D2FFC815BA" modified="2018-06-20" version="1">MDSHVRTHTKVYLVCPEVGCNFARADAAAISVHRKRAHGYVPLRRGPRKASGQSQPSSRQSSPDVPLYQCVRLRKGGRNTIHDALSNSASSGSRLANSIPPNRISPSHEAQTRNLPPPILPVQADALTHGQTYGSYGSIPPSQASLFYDATPTRDMLSPPVLPAQAGTSIPAYGQSYASHTSFNSPPRQISPSYTVQTRNIPHSVLLAQAEQRYASHGGSHGATEPPTPIELLERQFLHFPAGHTPVAEYPPLKEAGERAGTVERATWIYQQPSYLRSTMQPQDFRKTASDFGAGPSYASHSSQMGATSPLRQGSSWNRSAARYNPMMVGKPYNPYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTW6</accession>
    <name>A0A2R6NTW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTW6"/>
    <dbReference type="STRING" id="98765.A0A2R6NTW6"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="231"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="693" mass="77866" checksum="E0625E5C86DD979F" modified="2018-06-20" version="1">MSNVLVQPAGRHAPYDQLLGTDTTDLLAQIAPLQGYEHITILQDIAQLVDHLAQTVQEQTEGLCCDVYRNLVQELSAYIKFIAWVLSIDHELMSTELYPNLTTFTSKAQDTVIVMQAKLSSGALSQMDSRNDKQLNDYLGELRQSFVALDVVKALDAARLFALELLPLSFKFLCTYPQISNVMMNQIQEVVDSIKEPNRGCDRSKLCHMLRDISKQSGILPSSLFIHGVSRTDNDPVNGGSHADIYRGQYQGQAVALKRLRVTLQESSTQVYHKLFHREVLAWRQLHHEHVLPLLGVDCDTFTHYACMALPWMEYGDVLNCSSILRARDVPVPRERWMRELANGLAYLHAEELSHGDLRAANILVDSDLSVKITDFGMVSFAASLGSRPHGSARWTSPELLKGTIRCADQPSDVYAYGCVCVELYSQAPPFAHIEHEYRVIFAVLAGERPQRPCETAEASQRVLPGVRGLVPGQDVSNLLDTGDSTVGCAMPDSIWTLVQMCLRESPGQRPKAKDVRHQLDVWKISPNTSILIDCIPPIIVDEPRDNPPRIPERFELELEEDRLPTSIDKSGKRARNRMWRLLICSVLTVTALVAAILVFYYPTSIAIRITLVVVLGMLATITTLFLFLDYGMPKKESSQQLPWKSLKYKLRLKALYDETVWATQAFCEALKTLLIHKREKGGMLPSSKAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTW7</accession>
    <name>A0A2R6NTW7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v8354</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTW7"/>
    <dbReference type="STRING" id="98765.A0A2R6NTW7"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015317704" description="alpha-1,2-Mannosidase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR76596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="543" mass="59107" checksum="3D2A2346A946A729" modified="2018-06-20" version="1">MKGFLLCAALACSFNVGGVFAGLVQKSGLVLPSSAKTHQATVKSIFLDSYSAYKKYAWGHDDMTPVTKSFTDSRNGWGATIVDALTTLYIMGEEDLFEEAVAFVGQIDYNISHTTDTVSVFETSIRYLAAALSAYELSGQKHPILVTKAKQVADKMSVAWVGSNTIPFGEVEFNSSTPQIATSNIAEAGTLTLEWSTLAKYTGNDTYRRLAEGSVRTIASLPDPLPGLAPQGIDPSTSTFTDAYLTWGGGSDSYFEYLIKYPRLTNTNDNVFADTWATAVDSSIKRLAVTSTVGNHLYLADQDDTGEIVNVGSHLACYMAGNWILGGKLLNNATIVDYALQLNDGCWNTYASTATGIGPEAFAYFSNKGNYTGQTVTPELQTFFDQHGFFIETGSEYYYLRPEVLESNFYAWRATGDTKYLDRAASATSSFQKFLSAPAGFGGIWNVSDTVKSDDNFIDDTESFWFAEVMKYLYLTFDDPNHISIDEWVFNTEAHPFQAPPPKASYGSGTIGGSAFKQMSLPFKPTGPLPAVSPAPILKGHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUG8</accession>
    <name>A0A2R6NUG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000833">
        <property type="protein sequence ID" value="PSR76848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUG8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="248" mass="27874" checksum="917483E67D0AB77E" modified="2018-06-20" version="1">MKTNTSFHSLPLPTGEALLVTERALRPMVQECISGIIRRAEMGFNRRLKVWASFTSGEDRVYMAHTRLSAVLQQVLIQDTINSFHSVEEQTKLKQLWIGLLYDALTAPLDNCGLQSPLSGVMEVVHGNTEASGVIRLWTQQISRYLATSSLLSLTDVIQISTVACISNKAGSSHHYEWSNNYLPWLRIDTGGRYHMEYGMDALYDVLEARKKWCLHAGIFFLRHTVMAAAVATAREVIESIDRLGQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUQ3</accession>
    <name>A0A2R6NUQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NUQ3"/>
    <dbReference type="OrthoDB" id="2690066at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="899" mass="97017" checksum="BEEE548398A9E35E" modified="2018-06-20" version="1">MASSPIPRTRVIGKRESTLRASILDTALELGVGSSRTVANWIFNPVEEEDEDAESNISPSLTYASTATSEEFSLSPSFAFDRARPGAGQSGLAKSQDRSAGSPLQYSRSDGILSRGLTPEPSSQRMIQFDLSSTPEPRVPSPIPPSSKLRKLRKPKPDGYESDGGYVSDGGKGDKQKKDKKSKKKGGNEDETDGGYLSDMLGRRKTKKDKKKVSELPAIDNETDAGYVSTTSAARGKKKKTSKSSIISPTAGEESDAGNMSESSTKRRRFFRLNTKSRKRQDSSDVSLPEVIPPVPSLPPMPLPIAERFIRSETPSTSEQSRITTPTISERTAPQRSSDDASFLDTGSVSSPLDSPRALTKAFGDAQSIRTPSTDVLRAFGRQVGLHALKSPGAPTGSAPQSREGLDPTEAYYSMSTLSNGNVPMMGMPKPKRNFSQKRTPAHASAPNARALSARPRPIPMMLTPPTPLSDMNSVRASPRSPSSDAAFPPTPQSVHSSSSYFDSLTEGGEDAMPSPLLSPALPSGPIASPMALARPNALGKYDLPPPSPPPMGPLPQVPPSPSMSISQDSRTAQSYVRRPGTADNDQLPPPSPLTQRRLRPGTAPSDTAPSTFRSVSNGNLKGRPGTAPSSAPAMIRSESSPSIDSTPLFLRRIPSIQRGRESPFPSRPVLTPDASADLVRRTSPARPGARPSPIDSDEPPLSADAIHRGDQRKQLGVNWQPRSASALETRQYDDEDNIDSHSWVDFESANGSARTSARSSIESHPDIESVLSALQDGEDGDERDSQDFSDLYASRSREEMEDDDDRSRYPDEERSTAGRSTRYFDVDGNGDAEGDNRYSMWSEGDGRSRISILDDERSGDARVRFMKRVEEMYSKEGIERGLAPPVPALPPSGRNQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUZ8</accession>
    <name>A0A2R6NUZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000803">
        <property type="protein sequence ID" value="PSR77271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUZ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NUZ8"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR77271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="34575" checksum="B1FFC19ECEEC591A" modified="2018-06-20" version="1">MSCRFDPTGQNVAACSADRSVCKCVQSSSPSTFTYFVAWLALWRTYAPNTNYGLLSTLHKAPILDFQWSIFSSLIYTASADQTLSVTDLTTGQRARKLRAHRGIVNSLDRTLSGAAGMELIASGSDDGTVRVWEGGDDGGKQPVAVFEIGCPVTAVCWSADGSNIYAAALDNEIHVLDLRKNEQVFTLLGHNDTPISLSLSPNGSFLLAPDLESHTIIHDVRPFSPTPSRVHRTLMGAPAGFEKTLLRGAWSKDDGGRRVALGGADRTVCIWDVDSGNVLYKLPGHKGTVTAVDFHPKEPIILTGSKDGTMLLGEIEPSVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV79</accession>
    <name>A0A2R6NV79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV79"/>
    <dbReference type="STRING" id="98765.A0A2R6NV79"/>
    <dbReference type="OrthoDB" id="3003917at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="77"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="493" mass="54269" checksum="E793816D34134EA8" modified="2018-06-20" version="1">MPLSRLTPAALRVLNPNVLSSGLLGPSQARALHTLLTPFLLTPRSSSQKYHSRVAQLLVNEECSIPEDEMMWYAIKYEKTELDDEQPDEQEQEAADERWRVHWLQRMERREVMIQILLHFLLLSLPTPGRPCSPPLSMSPRKRKRESQDAESSDADAAAITPSLEERLEALMDKLSIWQLMGSIDNAVGGDETQRKPSSVWKGKQKAGDERDWMQIFCEDVVAPLFRGSLPSQCALLHAKVFQSSPFSDDSDPLSPSASPPPSPRQKEKQLNTEATSTKTASRSRGPQGLTCTPSSLSITLEEERVRERSKSLSIGPGQIRKRAVTREISMTTAFKGKAAKAKKPGPSAKDKRVRAEEMKRNAAGVVGANLAKSTVNGTTLVMATPAKPKHNKQQPATWADSPTGERCVDYNSQRGLAAQLQSALTEAAIEGDDDDDEWMVESSPDVLLLGSGGRQDVVVGFDEDLKGGSSVADFRSRVLAEGTPTKRSRHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVE1</accession>
    <name>A0A2R6NVE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVE1"/>
    <dbReference type="STRING" id="98765.A0A2R6NVE1"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF96">
        <property type="entry name" value="BCDNA.GH08385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51766" checksum="E94B97B431FC9C00" modified="2018-06-20" version="1">MPSSGLTHTQLTSLPTYQSTSSSRLKFLYSDFSRQKQSNPASYSSNVEWWRRTLEAVVLKGWQSTLGNAANLDRLVLHASGPALTEEFRLEGAGKPLGLATVLAELSATKSYFPVSPFLSSTPSIYDAGWLPYRIASYVVGKPLWWALQQLSIVGADDFSGHGGDTERWKKVRGDYVVLSLLERAGDGVLRKQQSKTGVSLAEELYNFDGFKREFAGDALDGVVLSELDVKVLLKYLERDKKAIVVQDEVIKFVQPNQSREITAVDIGVLELKTAVEDIEASVSKIQQQIDDRSEKISAALRQKRKEVALSHLRTKKQFEDLLKKRLTSLETLHSTLLRVEASAGDVEIMKSYESSAATLRAILAHPLLQRERIDETMDAMASANADARDIDEAIRIGTDVAQAETGIDDAELEAELNALVKDVEGERAKEQEERALQERQEQLDGLTVPEHLAKSPERVEPSKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW25</accession>
    <name>A0A2R6NW25_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000763">
        <property type="protein sequence ID" value="PSR78008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW25"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="82894" checksum="A562FE9D784C6367" modified="2018-06-20" version="1">MTITSLPRYPSTRSREALSPSQLTTLNTTISSSLAQIISLPPTKRDTPATITFISTYAKDHAQQILHSLIWGGENDSHLAKLSRVEQEIHQTVLRLAEKLAASLELQVFIDLGVIYGSTNPKRTRALFDSAFSHNASSLQIQLESDAIPAFTSLLSTPSQGLYGLRKMAHVLLSFLKPAPAELIRSFARSKHLVLALANAYDEGLAVVSQSYGSHHLERLSGASGDIQLDDWERIFLETKVALIDSFHILLQTLLKDVGDVDSAGSMLAARCEPAFEIVSALLDLQSSRPRPANPTPFLNQTLLEDYQRTYDLARVLSRTTRQADGSQLLESALQSLGSDSNTSERNGQAGPGVLKLLIRSSGVPPGIDNLGRGPSRVSAKGKGKAPEVVVQSNPALDAAVAQVLDILSDQDPEYVRFVLSHPDYPFKGDAERLIGALLEGVAPNPDEVAVAMVHASEAEGHGAVPLAQEAVKPFEYTKERRNIFDDERMDLSQLRVGKKKDESNVVLQDRAFIEQMKADILRRAEEVSDSEEEEEGPGGRKTKGSDLAFEDDLDDGGAVKVRDGDPSADEGSESEDDGEDGDATSKQPETILELAYIRDPKLFDRDAQTKRSKARTDLKAQTGWSDEQIEGWRIMLERNVSTNERLSPSTPFNQPRSFYQPQKDKILQKHEFAGNQPGLMPEAGSSIQGPRGGGRGRGRGGGGGGGARGRGRGGGRGGGQGGGGGEGGSGGDARERAWKDKNKASRGNHNRKRGHDKKMARAGGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW87</accession>
    <name>A0A2R6NW87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW87"/>
    <dbReference type="STRING" id="98765.A0A2R6NW87"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR78169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="522" mass="58140" checksum="59EEEACA4347AF29" modified="2018-06-20" version="1">MAEKALWHQAARELRFPYWDWSAVQVETDGLPKIFSEAQVTVTVPKNATTTLKNPLMSYTLHPIPVGAPDYSDGQLSVYFAEWVRTYRWASGERNPRENYTELNSWDYFSNTDPKAPPPPDAASLTSLEEPHNQIHLDIGGGGDMAYNEMAAFDPMFFFHHCNVDRLYALWEYVYPDYWIGNGYYDANGGLTPFRESPPLCGSGWKLNHRVFPEDPSGTYQEDPNTSISETSGLPPFRKDSNNYWVTKDVRGLQPSQGLTKYYTYDPLTLPVSDGTSNVVKQVTIDVTKPSTLEERTEYIAALHQYYGGNTVQLRDTTNLVAKPALFNHPVTDVPDTHQVVDGYRDFVIVVLLSQYAFRGSHRLELFLDGVLVGNVSVFSRINPANCEACVARIASGDAKTRGIITIPHALVVQVLEKYGLNKETTTDEEIVALLKKHIVAKIVNPIGSALAHASHGHVTASPGSHLPELKEEHRPNLRFHSTRVLVSAPGGTAPPQSVGWIDHGEVLGGEWRHATVQPISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWB5</accession>
    <name>A0A2R6NWB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000758">
        <property type="protein sequence ID" value="PSR78112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWB5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="15740" checksum="3DD810A7E5039B36" modified="2018-06-20" version="1">MAASTSTLSSHIEGISELDPVLQPVWRRYTNENDVQRFEDLPPFDDLPLPFIPDHRQRRKPPLMYFGWKIDADQWLEYAKSNNLAVMTRVSHFEGEDDPDFSEDENDDTPEIIVEEIDKCLSVAHVFWSFLWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWC0</accession>
    <name>A0A2R6NWC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWC0"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10462" checksum="94CCF43887C294A8" modified="2018-06-20" version="1">MHLDTQTSSAPSTVSLYKTFEGQFRLRTFPREAVFYDQSAKDPNGNGRTRSVNYVQDRRGGGRGKAVWNPRVGAQTLGSIVMKTSNADLQLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWL2</accession>
    <name>A0A2R6NWL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000740">
        <property type="protein sequence ID" value="PSR78459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWL2"/>
    <dbReference type="STRING" id="98765.A0A2R6NWL2"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="32981" checksum="DED3EB321655C197" modified="2018-06-20" version="1">MTDPNVVTAFAAAPLPAIPAEAASPHSTMLRGRLPRRTFLTAAAAVLTLHDTREKLPIYPSPEPVIFVQETPSELQRQIGNVREAATATYLDARARVQEVVSRWIGVEQAVERILGSVGRVQSLVAPEEPLNPALLYVGVATLTGSVLGRNRILFTRLLLPPTLFVLSFNHFLPKTAHNVSEYLGSLEERYLPTVAEKHAIANAHSAMTWERAKEATASGRESVTRNVGDVLARLQAVTGLKLQGALGVSQPFKQATKSQVQEIVHVVQQKTEEARENVEAKVEETTEIVEKKVNEIKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX56</accession>
    <name>A0A2R6NX56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX56"/>
    <dbReference type="OrthoDB" id="3249754at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="12345" checksum="B3E28BEABAD2354F" modified="2018-06-20" version="1">MPESVREQGIMVNPDSPSIDGDWLFYLSSVHKSQSLRARRRLWAIGEEIFRAVAEHRVGSEYDYVVSPDGQEQVPKSKTKKALEDSLADPVAVQLREMILSDRNNFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXT9</accession>
    <name>A0A2R6NXT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NXT9"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="79290" checksum="80CE61442F8EDDAF" modified="2018-06-20" version="1">MLPPMMYTACVQALQRLSKTIGRHDVASNVLEIHFADEEGDPYAVELAARLGGFVVGKDSDFVVLNSDGYLGYVPLDEMVWTGLQLEVDVVAEEDDGFQTVVNSKAKKKAALLQRAGVGHGIIPPEDSRELQLTVATYSPSTLASHLQIPLSLLPLLGALVGNDFTGSRDSSSATTAQETNLQWLFFERQLTLSQRITRVASAIKNLLAAALSPSPKNKQKQVHSVMELIERSVAALIVRPLDTISSGERSKVVERIVEATLQYAIPKYESDVPGPDSLWSSGICALHDVDACPLVQYISHSDTAAVLELASSAHDARTLYIQAYRAGRLDPHTLDIMHSGTFWYRQFLENPDLETVSRSLGRPLQIWSYALLDDALGLPENLDDDDLSVGEETVVSREEAEEAEDEDDDEDELIDVVEESDEEDPLAPLRGVLEKLNGPADGITTEPTASISSQSRDSRLSKSKSIVEYIRRGTRLAPEEVIVPSLAQLLPNTVDLEDSDIPVQLRSPDERFTFLLRILDSDHVLIRTLPAEQRIVVLTVRWVVLSMHLRAQESNSNKDRAKERWTKEEVQAFLASFSWAAPLDLEAAEEPVPITDRNVQLVAQISVALDAIERLSQVLLLCEQLPSPVLRFSGRLFHSYLTGFKKLVPEAIPDRLWHASIEQLNYALGESTAKNRKREKRKENVNRSTNVPERSTKSKGMAVLGGKFGLLASLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYU7</accession>
    <name>A0A2R6NYU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">PHLCEN_2v6651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYU7"/>
    <dbReference type="STRING" id="98765.A0A2R6NYU7"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR80735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="336" mass="37337" checksum="E94780D32E06CAAD" modified="2018-06-20" version="1">MSGHLLLPTLAGRVSLNRRSDRRENGFSTSLGLKGASVCLPLVVDLDDHLDTIDSEQTMELNDLHPPDDYSHRFFIWHEWIQANGPLTNENVFDYFATSMFYDKQSNNQVLRMQTMHTGEPLLNEAEELRRFTGIEFAVVHSQPPSLFIIHKRERLSADEEPTEDRTQLTSLHSLQTSLDTLRSHRPAYTPRTGFIWPIKEAPASEDSKKRSLEEVTDETQPPQPPEGLVDSSQKRKLTVTLGHKKRQNNVLLVNAMRTTAVHSTKSFSIPTALSESVVADTPASATAGRSSATPAPITQRGATPKLPPGSTAPQETASAKGPLIGGKKKKKREYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZY7</accession>
    <name>A0A2R6NZY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZY7"/>
    <dbReference type="STRING" id="98765.A0A2R6NZY7"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="306" mass="33088" checksum="1B16B55BB4BD240F" modified="2018-06-20" version="1">MQRDGGNDNAPAFPSPTAGPSAQPAHGGIFVSPSSAPQRFHNPLTGSPSEFDFIPQAPNFPASTSLANYMDQVRSVPSSYASSIYSDTTDNFPPTRGDSLTSFAQDALEVNNQLNALFSTELFDKFFCDAFEESSVHSLDGSQAVYGLNDMLNDGGNQLPYATETVDMQPFMGSMPPPDFDLYNLETNFMSAAAISTGPIPNISPVFPDPTVEPSVIPYPSEFQNYTHLFYTMFLAQIPIMHVPTFTIDGKPQILISAMQACGALYVRTQAAAKFIEQTLASARDQLVGEFVSGTGFPIMPPQIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZY9</accession>
    <name>A0A2R6NZY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZY9"/>
    <dbReference type="STRING" id="98765.A0A2R6NZY9"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015321622" description="ER membrane protein complex subunit 1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="26510" checksum="1E1AF3427BC10E20" modified="2018-06-20" version="1">MAHLSLPACLLLLLAGICFAEVITLRSQPNNHITDLSTSVRIRNAHDTYGTTNSIDDPLDLLDIVLVASVDGNLHAINRTSGHALWTISSPTAGDTPSTLGPLVRTKHSEPLPDSTDEEDGQEIYVIEPQSGEIYVMATPDSPLQRLPLSMPQLVEMSPYSMSGEGGMKLFVGKKETSLLLIELETGVVKATINPNSECPWDPFEDFSRQDDDDLDLDELDGTKPSKANRNSAEVFIGRTGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0E7</accession>
    <name>A0A2R6P0E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000589">
        <property type="protein sequence ID" value="PSR82343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0E7"/>
    <dbReference type="STRING" id="98765.A0A2R6P0E7"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="482" mass="55195" checksum="13193F2E54AAF487" modified="2018-06-20" version="1" fragment="single">MSLDQNLFTLTLSPNKDDPNITDLVDPSDNPHYRKERVPGNVYQMNVYDPLSQSLLATATAPNATSKHKTIELHNPSQIVELKYTGTLTFKWRFQWEQHEFEWKREECYILRKPDPAVLVALTKEPSGRIKTSSVQILDYNLNRFDIDDRKGLEIVILTALLTFQDSNDAYHTPPVEGMPPPAQISSPFAFFGSSRRASDTSESALSRQVSELPSQDAPLLPPRPPPKTGIERITELHMLKTLQGEGEANEIEVGLEGSADDYAQYAQRLLEGNGMEFIIIRSASASEVPKVLQVVEHTKRLRHKAGLDEEQELYQYVLYNTDKAKGPRRINLDDRAPTKEYTPPTSLKIHLSKIPVPELRPKAEITPTKSRVPSSSSRPPALLPDKSKERGNGTKEPKVDRAKEHEKERLRLFEQAREEREKAEKAKGKDKKDKRSDKVKERERLKEEEKERQREKEAEKEREKARKIAEKEAKRKDKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0M8</accession>
    <name>A0A2R6P0M8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v6033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0M8"/>
    <dbReference type="STRING" id="98765.A0A2R6P0M8"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PEP5/VPS11 N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="428"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="632"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR82600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="938" mass="104000" checksum="523D03CDF985F202" modified="2018-06-20" version="1">MSNQASGPAASAWRQFTFFDSVPVKDVHDLASSPEIFKKTPEFSCVISTSLGPLIADIHGSIYLLNDEFETVRSWIAHSGGRVTHMVERNGMLITLGEEDTVKHPFLKIWDLQTTEKKTGAPVLLRSAKVQSGNRPHPVSTIVLSATLSYLAIGLADGTVLLYRHLDQSIFSGSTSLTALPKPRVVFESPNEPITGLGFKEPSEDGPNIYLFIVTISRVLVYQASGKGSGGTPSAVDEVGCGLWCATMDWHARDMVVARDEAIYICGTEGRGACYAYEGHKSSVHTHLNYLVIISPPFTPSPSAASATVRNLFVKSADAANADVSKVVVFDLENKFVAYSGTFKEGIRDVFSAGGQIYLISNDGELTCLKEKPTSAKLDLLYRKSLYLLALNLAKTQRLDEANVADIHRQYGDHLYSKGDYDGSMQQFVQTIGHVQPSYVIRKFLDAQRIHNLVTYLQELHNLGLANSDHTTLLLNTYTKLKDVSRLDSFIRTESRRSSADGDTDELPFDLETAIRVCRQAGYFEHASYLAKKYDRHEEYLQIQIEDAGNYKDALTYLRRLGVEAAEANLARYGRALLSNLPEETTELLIDICTSLTPLTIDREERQPSPSRQASAGPSYLSYLALKSPVPSSDTAQASSASTTATVRPADRAPQRDASSTYDASRTSTPPPRTATPTQAGPIRARVVKRPSPRLYFAHFIDHREPFMHFLEIVALRRWGQSVSDANGNPFISVGLESPSDLQAEEQDQAAVWNTLLELYLSPSKDSSDLTGKAMRLLKSSNLPYDPTHALILCSTRAFTPGLVLLWEKRGMYEDVLRFWMDKEKEDPSSGASQEVIRCLERYGSAHAHLYPLVLRFLTSSSELLSKHTGDVGRILEHINEEKIMPPLSVVQVLSRNGIASVGLMKQWLTNRIKETRQEVDTVRRLFAVPPSSLTFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0U6</accession>
    <name>A0A2R6P0U6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v5920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0U6"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR82950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="63601" checksum="15377B9230D9857A" modified="2018-06-20" version="1">MSYPNTPPSPSPEPPKAPYEFDVAKWEHQQMAENGGNERTSYLALDPLGTHDSSPALVSIVDQDIYDDPNIDLDAEYLEDESPYPEVRSAVANTDDPDMPAGTLRAWILGLVWAIIIPGVNQFYFFRFPNITVGSLVAQLLSFPLGRLLARVIPRRRIWGIPLNPGPFSIKEHVVVTIMAGVGASSAYATDIIAVQRFQYNQIYSFGYQFMVVMSTQLIGFSIGGIAKRFLVSPPSMIWPSNLVYCALFNTLHAQWYVGMGKRGGISRERFFVYAFTAATLWFVIPGYLFTALSFFSWVCWIKPHNIVVNQLFGYQSGLGMSLITFDWSQIAFIGSPLATPWWAEGNVAFGFVFFFWFITPLLYYTNVWDAQYLPMLSRSAYNNTGQLYEVDRVLTNSTFDMKKYKEYSPLFLPMAFVMSYALSFASVTGNYSPKSTVDIMVQARRSLAEQPDIHARLMSQYPQVPEWWYICIFAIMFVFGVVSIEIYPTEMPVWAFCLALAIAFVYTIPIGIIQAVTNQQIGLNVIAELVAGYARPGRPLAMMLFKTWGYVVRLVVLTVLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P193</accession>
    <name>A0A2R6P193_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P193"/>
    <dbReference type="STRING" id="98765.A0A2R6P193"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10030" checksum="49FC7AD03D5BF16A" modified="2018-06-20" version="1">MEVCQFSAFLSGSQLYRLYLTPGLNHNQAGDTNKGVEIIIDVVKGEGCAAGKPFPLILPLGSDVHGVIKEVCENTTEHIETWKDVICSTDVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1H8</accession>
    <name>A0A2R6P1H8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1H8"/>
    <dbReference type="STRING" id="98765.A0A2R6P1H8"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="12442" checksum="4F1C1E5191938B02" modified="2018-06-20" version="1">MPQRRRRSSVSQRQSAKNGGHSMSERTPSRSVTFRPGKCLRIHWHANPTYLTPHILRLTAAKEEGAVIEIDGKKVALGIPGGKSAATGGDKSGSTSAYPGIPLARGGTPDEAAASILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5F9</accession>
    <name>A0A2R6P5F9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000528">
        <property type="protein sequence ID" value="PSR85640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5F9"/>
    <dbReference type="STRING" id="98765.A0A2R6P5F9"/>
    <dbReference type="OrthoDB" id="3260348at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015351392" description="CHAT domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR85640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="261" mass="28532" checksum="D8287CE155C846C2" modified="2018-06-20" version="1">MGHPKGSRVWWCSVGRLGALPLHAAGIYTDKGVLIEGFPDLYVSSYTPTLSSLIGSRETVVKGRSIPRLLAVGQSNSLPKVKDEFFKLKSLLPNNVLKIRDGDGAESDKVLADLRDHPWVHFACHGSLDAGSPFNSGFVLYDKKLSLRDIMQARLPNAELAFLAACHSAAMESESETPDEVLTLAAAMQFCGFRSIVGTLWTMSDSDGPVLTEKFYMHMLRNGLDDTDVCDSAEAVHLATKSMREAGVPLHRWTTFVHVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8K0</accession>
    <name>A0A2R6P8K0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000518">
        <property type="protein sequence ID" value="PSR87082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8K0"/>
    <dbReference type="STRING" id="98765.A0A2R6P8K0"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR87082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="338" mass="38515" checksum="5D614A982D80A9D2" modified="2018-06-20" version="1">MDPSLYKTITTSRGLHYSYYSSPAQQSKLTLLFCHGFPSTSNDWRKQALYFQDKGYGVIVPDMLGYGGTDKPTDPALYVSSVMSKDLVEILDAENVPRVVAIGHDWGSKAVSRLANYYPDRFIAYAFFAVAFMPPRPGKADFNELLKTSKERFGYELYGYQLFFSEDDAPIIIQDHIDSFISILWPYVPDIWRTHLAPTGVMKAYLLEDFKAPLPSYTTEEDKKRFKETFLKNGFEGPVCWYKIVTNGMQSEDDENIPSTQLVPPSSSPIFFGAAKYDYIAVPASGYRIFGGEAFKDHKITTHEYDADHWLLLSKADEINHDLEEWLESSEVVQKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8P4</accession>
    <name>A0A2R6P8P4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000520">
        <property type="protein sequence ID" value="PSR87013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8P4"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8065" checksum="B49F9463D1DC46C1" modified="2018-06-20" version="1">MSNSYIYSDGPPFVPPPDNVTIPQFMFGTTHPARPMGDPKSPCIIDDESGKGLSLHEVILISARSLSYMKANAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBX8</accession>
    <name>A0A2R6PBX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBX8"/>
    <dbReference type="STRING" id="98765.A0A2R6PBX8"/>
    <dbReference type="OrthoDB" id="3246760at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14462" checksum="ECF635ECF1C3A395" modified="2018-06-20" version="1">MLKGRFQSLKELRFLLESEEHLKFLIMWIRCCIILHNLIIEVEEESTTVDRLWYTKLREEGYEGRGGAERMDADEEDPDLPFVDEEVAGVRTEGQSFRHTLMQQLLASSRYRRDQARHAANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC97</accession>
    <name>A0A2R6PC97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 13">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v4933</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 13"/>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR88971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PC97"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15526">
        <property type="entry name" value="PHD1_MOZ_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="114"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="169"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="460"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="245"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="400"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="790"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="863"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1198"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="900"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1015"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1103"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1230"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1259"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1294"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR88971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1325" mass="147207" checksum="0EE7FF15024651A8" modified="2018-06-20" version="1">MRGLTFPKRALCEREESQELGTPFSHGDEIPIDPALSGPPLDPALLEEEARMRGLPMSFYPAPVQPQIPYHIQYSQGPQGDPFAPQPSPNYFPVEPTPQLPSKPIKKKRRHRPESQCGFCGGDYKKNQAEQSERMLSCFKCGRSGHPSCMHLAQISETLHSYDWRCNDCKVCTVCDEDKEESRMLVCDGCDRGWHMDCLNPPIEQEPPPDVNWYCPRCPPLEQQVHFESLEPDFIASCPPLPIRESSVASSSRSVPRNDMVKNTKKGKGKALVTDDSDVEVENEGTPVAAKGNNRRKSRPRGKLLPDGGAEAGDGTMLEPSRPNKRPRLRLSSPVPPSPKPPIIRLRLPARGKGKEREEEPDDSKKGMFDDFLAPEDRDVADTTITNSDKLRCERSRLIADAKLMPPPPSAVAEDSPVAGPSTRPLRSSHQLPPPSSRITPGASTSPAPSTPVVTAVHTPNQLRIRSIRFGEYEIQTWYDAPFPEEYMNVPDGRLWICEFCLKYMKSTFGAGRHRMKCKTRHPPGDEIYRDGALSIFEVDGRKNKIYCQNLCLLSKMFLDHKSLFYDVEPFLFYVITEVDDLGSRFVGYFSKEKRSPKDYNVSCIMTLPVRQRQGWGNLLIDFSYLLSKKEQRTGSPEKPLSALGALGYRNYWTLAIMRYLRVAPDNPRLEDVSNATAMTIEDVCTTLTQQNMLVSYDGAPTPRPLPGQSIRFVKGRKNGVARKHLQRTITQDDEKVKGPFVAPSSYEIRWNRESVEQYLAKWEAKGYLKLKPENLKWSPFLIARTRKSEGLPEAQAEVGTKQSEEPQSAADSIGTTDALTTPQSRTETPAFALFDDEVVESVGSSKLPMTRTLSTAEVVVVQSPKSMHSPEQEAPSSSPVRPRTRQQLSAALSPSTTRTPRRRTSTSRRTRSSIVEHSPRDEVDTIAEDAALAAKLAMEEDRPRRQLRSRSNTEQEQNTPIFSPLSPTIPTSGRKRGRLDSVSPPRTRSRRLSSASIRPTPTRNTSARVTSPVKRPRSQRKPSRLTKTLTNGHDVHEYNLAPQSPEIPITSPFSIHQSWEPESYEVGSSTVMEPQGSAAKGDVKDEDMGTPPTGVTSRHSVGHSDDTIAVDDHSVGTSKISPSVVLVQLPTQDGLDLRRGNNLNPGTQGDLPIRVSEQDRISGKLKVHLRREPDATARLPTGTELPERVTRGLDASVEDKLAPSPGLEVKNGHSTGTRYTEGISRVDELDQDGEMDAEGEPDVEDIDADGEDDLGELNVDRESSAETARVGEREQAEPNKMVGIIRAQSVGELDAEGELDAEGEDDVDAEGEPDLGEEFELNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGG5</accession>
    <name>A0A2R6PGG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000492">
        <property type="protein sequence ID" value="PSR90758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGG5"/>
    <dbReference type="OrthoDB" id="2742161at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104:SF2">
        <property type="entry name" value="CXC3 LIKE CYSTEINE CLUSTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104">
        <property type="entry name" value="SI:DKEY-29D5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="234" mass="27169" checksum="1BD007946838C469" modified="2018-06-20" version="1">MDLKLHISAYDINCQYRIHFDSRMAEFQELQEELEELRGFRCDCFPTTQAGIGKLHIPAHTLACRYKYSMHWLPGSAMTDGEAAERIWSVLNHLSLRTREMNAGHRHDVINEYHNDQNLRRTHQLARELTRKYTVAVKQRDSAVQTVENLEVTVTKHIGSDELAGWKRREEEWKVKVVDRRNHKDLDNPYELTKSKALSQKDALAELRENIVQGSTEDSLVGTIEEGVALQEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMX0</accession>
    <name>A0A2R6PMX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMX0"/>
    <dbReference type="STRING" id="98765.A0A2R6PMX0"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR93762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="295" mass="31579" checksum="E101FE0E1350E14E" modified="2018-06-20" version="1">MGAAENVRVFPGAAKPLIRPARHDPEIHGIDGLGGVEGLPPSDQEEVVARLRVNGVTVRAIEGIANAVRKTWNEGLGSKITIISSGPMTNIALFVSVFPELLGGIGATVLPSFEACLLNFATDELVFMGGGVGIGNRSSAAAEAAQIVLDTPVKKTMIPLNVTHTAIVTKGVHTKILSPTDQFKDERDALPPASTLLRHMLSTLLNYFASSYESTFGFMQGPPIHDALTVAYVSRPELFACRRFRVDVELSGNHTAGETVVDMWNYRSCDDSWGPAGKNCVVAESLNVRDDILVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN36</accession>
    <name>A0A2R6PN36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHLCEN_2v4716</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PN36"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000016">
        <property type="entry name" value="Putative Lysine-specific demethylase 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="18">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="17">
        <location>
            <begin position="203"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="405"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="19">
        <location>
            <begin position="571"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="37"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="320"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1593"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1835"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="987"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1597"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1617"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1651"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1688"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1758"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1847"/>
            <end position="1866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PSR93821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1926" mass="217011" checksum="53213CA9CDACFEEB" modified="2018-06-20" version="1">MRTSPDSPGRAGSSTAFSSRPTATFTTCLDIPVQGAIPIEKLDHTPPGSRKEVQQPSVTDSKRAPRKSKTDAIAALSANSDREDIQSRTQDDAGTKVKMRDGPPISVNPVLDLSSVKTPNPRNMPSKPKERPFGLTDCPTFRPTPEQFKDPMAYVKSISENAKSYGMCKIIPPLGWAMPFVTDTETFRFKTRLQRLNSIEASSRAKVNFLEQLYRFHKQQGNPRVSVPTINHKPLDLWLLRKEVHKLGGYDAVTRSKKWADLGRLLGYGGIPGLATQMKNSYARVILPYEHFCEHVRNSPNMSPSKPHDPTLKTHMNIQSAGKSVRSSIGAGDDSPPSSPLTATSSPLSEPPDESDKNDSTRPRRSARQTSHEQPTPSHKPPSTIETLPPSLNGADSKDRRSPSEPHCEVCQKKDRGEEMLLCDGCDCGFHIFCLDPPLSSIPKGQWFCHICLFGTGGDFGFDEGEEHSLSSFQARDLEFRKLWFSSHPPSKANGDRERVYDGDAISRANAPDPSVNRFGDIVVSETDVEREFWRLVQSPNETVEVEYGADVHSTTHGSGMPTLETHPLNPYSKDPWNLNNIPILSESLLRFIKSDISGMTVPWTYVGMIFSTFCWHNEDHYTYSINYMHWGETKTWYSVPGEDADKFEAAIRREAPDLFEAQPDLLFQLVTLMNPQRLKEAGVEVYSCNQRAGEFVVTFPKAYHAGFNHGLNFNEAVNFALPDWLPQGLDCVRRYQEHRKLPVFSHDELIITITQQSQSIKTAIWLNDSLQEMVDRELDARTQARAMEMDEVLEESDRPEDQYQCTICKTFCYLSQVTCACTTKVVCVDHVDQLCKCPKTSRVLRKRFNDIELQDTQFKVAERAEIPSVWRAKLNKLLSESAQPNLRSLRTLLSEGDRIIYPLPELHSLRKCVTRANEWVDAANSFLIRKPSRKRPRRLRGRVSGGDAAIGDEVMVDKSDRSLEDLYALVQEVEDLGFDCQEISALRVLTKDAEETKAKAKALLDTVASTRERDAYIQECEHLMLHGSTLNVQVDELLEVEKIVMREQLLKEMEELNFDQLTITDIRHLLSRGRLCGLTLGNERMKSLDIRLRTGQVWEDRAKAVLEKPQRTLDELEEAAKTLPGVPIDPGLLETLVNSRARGKEIERQINAWMVPDPALLKPRVQDVVKLVSRGEKEFNILILQDMRRTVDFAVDLESRCDSVLKNRYQHNDESDVFSTMRQWHTYAKEHLTMFTLPNLERFEKQLTLHFRWLEGLPWYCRAHHAAHGKPILEDVVDSTRPEDDLPPTDEYFTCICNIPVRPPLPGTMSDAVQCDHCFARFHGLCAANGGSCPFCDHQHWNGTIHKERSWHFCYLPTILMHAPEITKNYSEDWKELEIMVHRVDRLSGVIGQFLSFASQPANQRAEYIPQVRHYMRKLYKIQFAVSPNPEISYGLDLAGLHRILAGQPTPVRMKKRRRPKFTFGQDLDKDWVDGTRCICRGRTSYLLNYPTVECELCGKLYHGGCVFFPIDATLGSNNRFMCPLCCLRKNRTYPYSEVRVKHIDNPDQDMYVDTKEMLDTFSKDIVYTKLPHPYTQTLFVELCRFTPGQPDSMAGNASTNGNGSATPTRGAAPLSSGSQLPPQNGSSQNGFSPHSRSGQHSMLHHPSHSSHSSLPTPQSSSPHLSHDPSRASPGSALHGPPPPPWSGRASRWSNAAATAPPPSARNHPSEVASPSNTPPLASRKRKQPDDPSGSTDEIVLTNPPSNQPSPKRRPTHTPTTQHQHVHIPPMSQPMQLPPLQPAMHMPGMQSVHASPLHMHPPGMQSMRTPPMQSARSNTGLSPSLAMMLSPTAADRGMSSPRQHQAHQAHQAQHQLQHQLQHQSPHQPPFPGRIGIGPQPVGPSRMMPEEIQIPPHPVRQVHIPFQPVFTEDDFRWELGLSNDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNA5</accession>
    <name>A0A2R6PNA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNA5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7221" checksum="51797E9391ADF9AB" modified="2018-06-20" version="1">MVLISSSTLRPLVSARRKWWGAMEIGGTSSNLGYFLSSMDYRPALRNGYRESSNIVGRVVGEAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7K7</accession>
    <name>A0A2R6Q7K7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macrofage activating glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000382">
        <property type="protein sequence ID" value="PSS03726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7K7"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7K7"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015320686" description="Macrofage activating glycoprotein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS03726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="36423" checksum="F827D3FAFC1CC5DA" modified="2018-06-20" version="1">MFFYLTLISLPILVSAQTYSATYLPSTAPKTTEDGQSGTNQCGTNSSQDSMCQNLYVNSVDDFCLFAPPQPGATSSISFTERIEVAWCIKSGYGTRLIPDGSITGAHFVQTPDFVQVTGVGDLTKMNIPAGDDGGELDPHGADGNGNPIGGLLFSSAFGDLEQIHEWTNFMSASLFCIRACKPGPQAPQWCGHVWDVMGCEWNMPANYDDGVFERCQGDSGLPMGIYGTSTFSQGQPSTPSAHPIPSSSLCTTVSTIGNFAASQASSSTSSTSGSSAATTPVSSGVSGRSSSPTASSSHSGGASNFSQSSSGTPTPTGGSNQPNSAVQIGKVGLQWAFVAAAMLFGASTVAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB70</accession>
    <name>A0A2R6QB70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB70"/>
    <dbReference type="STRING" id="98765.A0A2R6QB70"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="96079" checksum="D71C7B7704505BD6" modified="2018-06-20" version="1">MSASLRHTSGATWANVVTRAAPNFTAWTTYTDGHLIGVDQNVTQEYMSCLQVFSHMGRVDGEDSEVRNRTRLVGLATLTGVVTSEALYHSPTQFKAQVTTLIPALVVPLLEVEVLSLDHEAAEVKEQPNSPYLDEFRNRPAMERRALSIHLHVTGETGPTSRDVANASLRALATLFGHSNGPQAAVSMRAAFDCLHAINAWERPDHCRWVAIRAAEWTQYQYRYAIPTKLVECLVQEQDAPQSTPQHMRLAEMITSVFTSPTPLVNLSTSDIISNLISVILRRIAREPDDMLLPALVQSISSLGIHVYYSDQIQDLAGELISRLVVVETSGIVTRGKSDLGKGRTQAVRCLLAGLFGLMHAAETYDGDKDEDDNKGAHKAGASVTIPDPPSSPHPDAHVRPSYSDGHIKPSRRTSITPEVFQETLTLICDGDYAVRVDYATTIVSYLQREIPKLGDYTDADGVKRVRPVAEGPTQQASMNLTMVYGDSTTRFLHALHAHLYVLATSSTLGLAPSTSSPSPQRSVNEEASTTGTDDNVPQEQQEPTEEPRRRSLAIPRSRKMSVMKRLLRGTLTGTSLSSIPATLSDYGNILVVLQAVHEHLPIRGLLTGVPMLLALDAAIQGDAACESAGEQRVQAIREALARTWLVIGKVWDSPEVTQLVEKALSSSPASPLPPLSDVEPGRFHPAREPISFDATNVDAEKVHQLDSQGLLMAITSNKTVQDATGMDRQGLLRKFTAPWSAESAFKDSTEAQSPSSDLRTSDGLSPLVKVSPALMHIENLSRASLARSTRGVGVTDLREALEGRSSLSNTNLANTAASLSTLDHPSTVHGEAYKLAPVRSRPQQRSKLAGPADVKDVLNKLGIGKTNGNGMLKPSFSSKKPEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEH7</accession>
    <name>A0A2R6QEH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000361">
        <property type="protein sequence ID" value="PSS06545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEH7"/>
    <dbReference type="STRING" id="98765.A0A2R6QEH7"/>
    <dbReference type="OrthoDB" id="2980978at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="336"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS06545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="825" mass="94632" checksum="768E4CEAC2B04F4D" modified="2018-06-20" version="1">MSQTMNQDEDLDADDNERYPDEIESEPFVYSDATRTRTHSSLPALDRTAAFRQFLDAQPPEDIARRCREAIRYMADNLKLDITLLLFYISWNLPETTEDKVIQYARTALMWSDELPSIIKNWHRPPRKHGVGVRTKAASTALESWAEEITKRKINEEMRLLGPYMRLKPSEISPENLLSITMADTIQTVQTHAPTMWSLCRSASYTPIQEMKNAKKNPDLVLPRMLGLYFKACGTSAKGLDTLHALGISISQKAIHDTVNAISCSAQQSLRKDILQYPYGGLHDNLNQQIRVYEQRLSNQSHFDSGTAATIFIIKDPSAVAPSNRAYQAQLEIGSSNPITFLTIVKLDHSASHRLRSQAIFRILSILKDAPPFGFNTYEHKDSEIFNRPPPVFQLPTGPLTAITQYMLDTIHIDQSSYEGNEACLGEWNRQTGQDSLEAQKKMGTEKLVVWIGDQLTTSRIRGIKRYHRQDLNASERYEYLLEHPGWFHTQITEGHSFHNQYYGTSAALGLKHDFDLLKRKGLGAPSTQGNFHHNINEALTHIAEARFRDLWCVAGGVQTLNELQNRSPEELEALANQILDNYASTRALDKQRSLPRQDDILIQAIQFNRDILPFLDLDDAIKTGDVGRIRDLLPRLLFRFIGGGNSNYVTECLELLQGLEREWPEDLKQFILKYCWLANTTGRPGLFLPFDMLQEHNIRDIKHTFASMGPYATWDYIKRISASIPTQRRIKDHVEHEINHFFRGKSHTSPEKEEDVALLQSSYSMTKMHYYNPRRQLHATDKVEDYIAKGADFSTLKRTVNNWAEKRKIKKAKTEDWTFGYNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUH2</accession>
    <name>A0A2R6QUH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000311">
        <property type="protein sequence ID" value="PSS15400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUH2"/>
    <dbReference type="STRING" id="98765.A0A2R6QUH2"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS15400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="391" mass="43053" checksum="ADE8DCD0614B1790" modified="2018-06-20" version="1">MDSSRKPKGKKGSKRGQSCRKIEDLSDAPMPSSMPQPTVKIENKMLLRAALKSAADSGTFIDTKFYAFSRRDPSRTAYEPKAVYANGWLLRARLPSYFEPLLAGGYKESAVGSLHGNFPSNHQAYNIEYGYDSDSDLEDDEDSDDGDGVTLKTDREEEYMTDEIPQPEKDVGDKTEAISEELLKEHGAYGTGRVVILRDFAYPTWKALIFYLCTGEVAFAALQSQKKENIPAGQISPDAPLCSPKSMYRIADQLGLDALRNLAEKDILSKLSADNIMEELFSEFTSLYDKIRDMETQFACDNALTRTSANISECIERMATGQRPYNAVILKCLFQRFFGALEEARSSKPGPMYCSSPNCRNTAVGGSGSSSKAKLTTLACASCLGTVGYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUJ6</accession>
    <name>A0A2R6QUJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000309">
        <property type="protein sequence ID" value="PSS15412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUJ6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS15412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="10984" checksum="15DB41A725CFD1C5" modified="2018-06-20" version="1" fragment="single">LEFLVKTIAPRSLASETTDAVAEASLAIDHLSPPSAIQTMVRAKEVGGELLEGADIVEEALSPIVKKTDFSAFIKNVEVFVGIVDTIAEVCCAVYWLVAHLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXQ3</accession>
    <name>A0A2R6QXQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v3221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000293">
        <property type="protein sequence ID" value="PSS17133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6QXQ3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS17133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35041" checksum="39FD6E27FB15FDBE" modified="2018-06-20" version="1">MDIPTIFYTYPSWMVIGFAVIVSGLLFAKQDKSKQAPLPPGPKAWPIVGNAFQLPKEYEWLTYQEWSRKYGSDILYFTSWGQPHIVINSAQVASELLEKKSSLYSDRPRMPMLNELVGFDWDFSFMPYGNEWKESRKIFTQYFRPTAAANYRPIETQKTRDLLLELLETPEDFMKLFRILSGKIIMALVYGIEVQKTSDPYVGIAERGLQGANMAGNVGTYLVDFIPALKYVPDWFPGARFKRQAREWRVDVDAMITVPYNAVKSAMENGRAVPSMLHSMLEESGENADALRSKLTASVPAVAYNGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXR4</accession>
    <name>A0A2R6QXR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000292">
        <property type="protein sequence ID" value="PSS17143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXR4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015306113" evidence="2">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS17143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="285" mass="25913" checksum="A5EE488F4A47B7CB" modified="2018-06-20" version="1">MRISFFAFTILAIAISDVSAYPAVPSLGELQLIELRKNSLDGDHILTRAIRYGGSAHSGNSGDANGGAVTNSGSRTGTVSNDGAGTSTGGLGGTTRSGSATGGTGSGNVSGGSATSGNAGSANGGSVTNSGGTITNTDGANVGGNGGTSTSGSATGGDAGGDAGKRAFEGELVNRASRYGGDASSGDADDARGGRVVNTGSGSGTVTNSGASSLGGTGGTSTSGSAQGGSGSGEGSGGSASSGNAGSASGGSVTNSGGSISNTQGSSVGGNGGTSRSGNAVGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0W2</accession>
    <name>A0A2R6R0W2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000287">
        <property type="protein sequence ID" value="PSS18881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0W2"/>
    <dbReference type="STRING" id="98765.A0A2R6R0W2"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS18881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="11363" checksum="9BDC062A5EB5F98D" modified="2018-06-20" version="1">MSAHDMLKQLSSQSFPYKHLTLTPFRLTKLPRAAGSGVVKKQVEAEAIVEKWEKSSWAQKRAAIEKRRSLNDFQRFVVMIAKKSRTDRVRKAVHAAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3W3</accession>
    <name>A0A2R6R3W3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3W3"/>
    <dbReference type="STRING" id="98765.A0A2R6R3W3"/>
    <dbReference type="OrthoDB" id="2757304at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="35405" checksum="690EDE39D8C52CA3" modified="2018-06-20" version="1">MSQDPCIVAGWLISPCLTDPFEAEVPGLYAGLGPDYYPPPGSTSDGFTATDCACNTVLYSLLSACAVCQSMTYVSWTSWEAFCSKVYVASYPDNIPSFTSVPQWAYLDVTKANNFSVSDAQALVAKDLPDVTTPGGTSLAGSQRPAPSTATGIAVSPTSAPTVNPFSIPSDTFSFSIPSDTFSFSIPSESFTFGGSNPTSLPSSFTSSKKKKTNVGAIVGGIVGGVTTFFAGLWGWIAHRKRKHAAPGVSAASGAPSIIPSTPDPEKPVHGAASPMGHSPAQDPALDPQFVHVPHLPMNARLYDPDDPSTYPDAQTHVPPPTHSSQDGASGTGSYVPTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3X8</accession>
    <name>A0A2R6R3X8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3X8"/>
    <dbReference type="OrthoDB" id="2753495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS19936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="206" mass="23130" checksum="13C5F157266EF71E" modified="2018-06-20" version="1">MTVRHFLIRPVPAYGKYTTQSVETYIKRHASKFRVDEIAEDPIIEQVIREAINIAQNGQRSNLRKAIFASVTGKESLDHFATRMINDWHMGKQPSDTSKKSITAQLALAREVAAPLAKAKNQRGADTGFWKKINEKLKALHGKHGVVQGRSSPGWHEWEEDVIHKDIEIYGNSRAGASSLGIDDEDGYDMMYNTLGDDLEADPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R773</accession>
    <name>A0A2R6R773_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000279">
        <property type="protein sequence ID" value="PSS22599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R773"/>
    <dbReference type="OrthoDB" id="2670618at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="316" mass="34230" checksum="A9DAB930595FDCFD" modified="2018-06-20" version="1">MQIQQNPNHIPRVQISTISHSSKSTSTSSTSTTAAMNADIANVIVQFCRGGRTISGGEPCDCEEYDPPDDSTAAARCKECGHGKSKHSHPPSSSLGHGHRLAVPPDSYRNSQSTGGGSSASVRKIFNDVTAEESASSGKGKQRASKSGYSKVSADAARKEVLQGFRKDPAAVDTASSSGSTKKSEKPTFQGNESLEDEQCPGATHVDLLERCGCAATAATHSNENRSLQIRVDWSFQDVDQHLRNLFPKPFEYIENNNRFSNRHSLWRVLSKEGKKLVVTAAKRPTGADLIKFKGCQKSSIRDSHIWIGANMIIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHT1</accession>
    <name>A0A2R6RHT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHT1"/>
    <dbReference type="STRING" id="98765.A0A2R6RHT1"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS29569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="638" mass="72102" checksum="0FB9E2FEC1F474BD" modified="2018-06-20" version="1">MSTVWNVEFPASDDGENRLTAFRQIINAILDGRQRSQNREASEPTADGFDPTGSQITDEDFSHVLAELVRDGTVVLHEDEEAEDEDDHEEDEEEEEEEELDDDDDMFGYYNDPISNGRWYEEVKQPKQEGMSLLFSGEFGRIRHQIRSRNEKSNVASILLNRGTKIRPTYKEDLLSDLVPNSDGTAVANYYANAYVGQYSSDSSFYYTCVRDFRLHVYDTTAPVTPTVPSHRTHRTRGGIMDYDHDTSMKVIKTIRAHPGGWTITDSHLSPDNQRMIYASVSNIVYMASTLDSNPTQVPINFADPVRRGGGYGYEDHYGVWSCKFSADGNEVIAGGTEMVFVYDLLADKRTVKIKAHEDDINSCCWADTASGNVLVSASDDTFLKVWDRRSLGSSPKPSGVLIGHTEGITYVSAKGDGRYVISNGKDQVLRMWDIRKMRSSLDFEQVKDRHYGIPNYDYRRGIYPKPRYKAHPRDCSVMQYTGHEVLRTLIRCHFSPAETTGGQYIYSGGADGRIHIWSLDGRVVQVLDRSGTLPMSYDPSGPQPAQVKFPHRKVCVRDVSWHSQQPILMSAGWLGSGWGANESSVIARHEWKGLSKMQYSLEDYVERQTSERAERAQRRGVLRSMPGSYQVDIDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHW6</accession>
    <name>A0A2R6RHW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHW6"/>
    <dbReference type="STRING" id="98765.A0A2R6RHW6"/>
    <dbReference type="OrthoDB" id="3247214at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="472" mass="52215" checksum="D6E189B1082BF01A" modified="2018-06-20" version="1">MSTQQPLEQNSSESESVFVRFRRSLSGSFSQTNAPSSQPSTQKTEDIHPTSRPTTPRQPTTFEKLISLGQSRKDWEVDFPPPHWSDQTGSVPGAPGMVLELYFFSITIVSPKETAHEPPPTTNPTREANNEPPPEPTTLAKRIQSMLASIPPILSSNSTQEPKLDGEGPPPKLVSDPKMISFLSSPGIMNGSLSKSGQSVWSVLDKLRAQLPGQDKHRADIPLEERKGEEEVLDDDESGVMIYGPLLPTADSEVELAKSEMVPHDNEESKQDGKKVPVRKETVVDKLERMWPFGKEKEKASDEPSESRVFFQPVKEKRVWIPSKDKISIQVMWWGYRIYLPPPVLDVLDNTKIEGAKRAAMLTAALKWLLDRVPMAMLPPQARPAMAMLKAFTPYLGYVGGVVAWSWGAVKTFDKGNGVTLTATWLLSVAVIPGTWEADEIPGPVDIPRENEATQQQPSEPGLATENPTKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHX3</accession>
    <name>A0A2R6RHX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHX3"/>
    <dbReference type="STRING" id="98765.A0A2R6RHX3"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF68">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="289"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS29622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="661" mass="73125" checksum="568DBE7B76C40BF6" modified="2018-06-20" version="1">MIAEVLLVLAGHSSSLFPTDHTVHPAFAPLLHPGEQQCLESLGRIACRYRNVKAISEKLSRYPSRYTSALCATLNQILQDDYEKLVVETEAKVLRRDSSLVACGTLVPLSSIRATFAEWDAPLAALECLVEDLQAQEHWQPGPLIDMLIVRSHTGIHRVASIYARLCTAVQRIWVRQLQALLIHGSLSEVDPLASKEYVLLQGAIPNCVSSQSRESIAYVGRAIGTVKAAKWDKQFPKSLALDHVKILATVLPQEQYVFDRIIADIRTTVSEWLWANVLTQKDVEEAVESLANYFLLRNGEFALSLIREIERLKVSRLTGRTGPTTMIREQDLHLALLRASLGTTAQHDPSLSRLRFELPAGPLRPLLPSLTAGPNHKDLSISLSNPPEVTSFDDLLLGTSLVLSYTVSWPLDLFLQASDLQTYAALFAYLSALRKTHTRVHTCWASLSNAQRARRRWTGLGEGGTAEDLAVRGELLRYGWGAVRQMSWFLDTLLGYVMTDVVDVEFRRLKSLLLGKPVSIGRQMTGAQSTDSVAPAAHSVRTHAHTQSVGSAMSTPTSSPLDFSSLRDIHTTYLERLVTGSLLADPAIMSIIRVILEVCERFVAQVERWGGDILPALLFEGSLAVGGDKVGEMVEERRTIVTEINDVSDRPQAQRTLLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLS3</accession>
    <name>A0A2R6RLS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000230">
        <property type="protein sequence ID" value="PSS30959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLS3"/>
    <dbReference type="OrthoDB" id="2795185at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015354308" evidence="1">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="250" mass="26750" checksum="2A6353B49E25FCF3" modified="2018-06-20" version="1">MRWFAILQFIFIAASPVVSVPSSYDTSLHFLDKRDAVCGSDFRSLVDFSSCLPNQVAFTSTPPAVTKEVLPDTESSSVPPDSQCDHTVELQVLDFVAKAAKLCDVLTAMANVGHSKQTLLQPASETISGLQNLNFLDKTVNNNKRVVVQRALKGNKQTSQPKDLAVGNYLALVKADSQKVASSLDANIATIITTAQTVLKGLPDGTTSKTGRKDKAAANKAALSSALEEYDKTKTVTAAWNNILAEAPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM27</accession>
    <name>A0A2R6RM27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v2419</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM27"/>
    <dbReference type="STRING" id="98765.A0A2R6RM27"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS31087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="19003" checksum="D6956F06D0B20C65" modified="2018-06-20" version="1">MQALRLARPRTSFRALNVAGVRSLTATAHSSHASPAPTTVSSVIPLSNVEAQWERLSSEEKLSVHQQLEDIQKKDWKTLSLDEKKAAYYVAFGPHGPRAPIHPPGTGYKIALGVAGLIAASGAIFLAVRSRAPPPPRTITKEWEEASNERALEQKSNPITGISSEGYTGKGFVTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM72</accession>
    <name>A0A2R6RM72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOPA 4,5-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000217">
        <property type="protein sequence ID" value="PSS31130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM72"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11405" checksum="A11813D8EF77F3DE" modified="2018-06-20" version="1">MPWKSPLVGYENAEPLPTTVNPDGKSLYNPPGPKSLAYDEFPEPIDSSNNGFDFHIYYMQADPEQTRFAKELHERIRREFPEFLSGFPSNLSKAPRASAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPF9</accession>
    <name>A0A2R6RPF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000215">
        <property type="protein sequence ID" value="PSS31914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPF9"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS31914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="37127" checksum="D8C63B2EB78B9B09" modified="2018-06-20" version="1">MRLSRRSGLAITTPPTSPVGCQSTLVNWQGGQAPYILDVYSPNAQGRRIQSFPAIPGLQLAIFFLPGVTDTMVMAIQDATGANDTTDAFQLIPPSQSRTLSCLIGTEQPPIPEPSTINSVAPTDTVTPAAPSVSIALNPGPTSSASHKASSMSNTEKVGLIVGITITSVAILAVLVILLYIVKRRRQRAVSRTPQSSPFDDVYVDARHGGLGRYGGVIDRGDTVREVALSQGRGNTTRNDIGRGRAEMRLTPFPMAAVAAPTSGKQASANRTNVSSTGQLSSTNPNSPRPSHSETVSISPVAFNRPHAALDSGIRFGHSASDRSESRSNSSEPAPGSLPPAYIQPLNVMLNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ48</accession>
    <name>A0A2R6RQ48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000192">
        <property type="protein sequence ID" value="PSS32160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ48"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="11481" checksum="02C90E7C3B8A39FF" modified="2018-06-20" version="1">MNIAQVLVDTVVVGSPYDAQDTFNSRFSITGLRVPTLASVIGNMGEHLDHGPVEEVEDEPDDVSDGPLAGEMVTSEVIIECCSSSSQKDPPSNNTISENNIQEVLCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVF3</accession>
    <name>A0A2R6RVF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVF3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="13039" checksum="C9FD9BC00C18286C" modified="2018-06-20" version="1">MGLSTGDGLNERKESVTVGRVCVCSDGSESRYRDELGESAKFMKVPFDKASVSESDSESLITTIRDEHMFISAIQHRKTYSSKDRYDSEGSIQVVLQPLRVPCELSLDWGGRCDSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVF9</accession>
    <name>A0A2R6RVF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000171">
        <property type="protein sequence ID" value="PSS33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVF9"/>
    <dbReference type="STRING" id="98765.A0A2R6RVF9"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="3">
        <location>
            <begin position="144"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="384" mass="40977" checksum="9CCFDA1538835B91" modified="2018-06-20" version="1">MAPIRIGFIGLSSRGWASTNLVPQLFHPLLSSSYSLTALSTSSEASAAAAAAKYSELAGHPVKGYHGEQGFVDIANDPNVDMVAVSIRVPDHLKAVTPAIEAGKDIFVEWPPGNGYEETLKIAEAAKRKGVRVLVGAQATHGVYLNKVKELIDSGKIGRVLSTSVILSAPTEMPFGGLTSEVYSYTADINNGATLLTIPVGHFLVAVSHAIGEFTEVTASGAIQYPIALVRDSDGKFTGDSVPKTAHDQLSLSGIIRGSGNNTNAVFANIHIQGGIPLLGEKGRGRTALKWIIDGEDGVIEVLKKEDDTPALAFISTVEKRVLLNGGEVELEEREEDQLENAGKAWLEFARGGRYWSIEDAVRVHRVLDAAQRSIAEGKKFVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZD2</accession>
    <name>A0A2R6RZD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v1668</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000135">
        <property type="protein sequence ID" value="PSS35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZD2"/>
    <dbReference type="STRING" id="98765.A0A2R6RZD2"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="350"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="611" mass="68046" checksum="4FD1A2FCE2EA5C85" modified="2018-06-20" version="1">MAWKGEEKAEVTAIPSGNIKWAQWIRVARNYQLRIGHKDQKDQNGKDAKSKDMKRDTFDGFVREDHDKLAQLLKQHFSIVLESKEVSVKGWNWGITDFQGQELAFLVSNKTAFELPLINVANSNIAGRTEVSLEFAVPADKKSSRHAPDELTEIRFYVPGTHAKEARGSDAGIQKSDQEDEGEGEDISAAQAFHDAVKDKAEIGQVAGDVILSFEEVLVLTPRGRYDVDMFPEFLRLRGKTYDYKILYTSISRLFLLPKDDQHVLFILGLSTPIRQGQTRYQYLVMQFSRDEESTAELNMTEEEVAKYDRLKKSYDDPTFEVVSGVFRALSGRKIIGAGSFQSDRSRDGHPGIKANLKAVQGDLFMLEKYIFFVSKQPTLIELSDIHQVVFSRLGAGLGATAARTFDLKIVTKTGPEYTFTSINKEEHEVTEAYLKEKKVKVKNEMMEGELILGPDDEDEEMQSVASSGEEVPKPRLGADDDEDSEEDEDFQASETDEGSPSDTSSDEGGQTASDASGDREFTRGTKGKAKASKKKASAKKAKAAANESDADDDDKPKKAAPKPKPKPKKKDTDEAMDVDEEKPKPKPKPKPKAKEPEDGPAKKKLKKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZG2</accession>
    <name>A0A2R6RZG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZG2"/>
    <dbReference type="STRING" id="98765.A0A2R6RZG2"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="163" mass="17911" checksum="420F9140FCC9DCA9" modified="2018-06-20" version="1">MSDISRQSSPRITPLSASPNRPSPLSRPHWPYTTYTHRPSSSAPSLNSTASSSSGSQAWDYRSSAGTPSPSGLVRRTSNLSMALNGVHDEGQNTRHWSFTAFEWVVRDVHRLRDYVENINTVSNLEGSNFDILKESPMLGDGKFKLEIGNIVLNAPSRFCSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S012</accession>
    <name>A0A2R6S012_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v1439</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000111">
        <property type="protein sequence ID" value="PSS35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S012"/>
    <dbReference type="STRING" id="98765.A0A2R6S012"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46530" checksum="0370EE4A82BA8B7B" modified="2018-06-20" version="1">MSIPLAFLDFVLVALGIFLVTQLFTGRSKPSLPPGPKGLPLIGNVLDMPPSHEWLTFAKWGERFGDIVSVTLFGQPMIILNSAQHAIDTLDKKSSIYSDRPMIMMGGEIIGWKYTLILTPYGERFREYRRFMHRLIGGHKQVERFHVLERDQTHRFLKHVLHTPEKLSTHIRRTAGAIILQMSYGYEVQEKDDPIVDLVDIATEQFSLFTSPGAFLVDVFPMLRYVPAWFPGAGSQRLAVSWRKTIHDMADIPYEFVKNRMSTHTNIPNYTSDLLENEELKGDKEFNIKWSAASLYSAMTLFPDAQRKAQEEIDAVVGSDRLPGYADRESLPYVGALVQEVLRWNPVAPLGLHLADASVWISCAMSLAVFNVTKAIENGREIEPVVEYTSGTIRYGLCIEITRIILLTCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S029</accession>
    <name>A0A2R6S029_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000109">
        <property type="protein sequence ID" value="PSS35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S029"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="786" mass="88918" checksum="5BC243E1311B8DD1" modified="2018-06-20" version="1">MDGLPLEPEPSDFVNEGLYRNYHPKLTGRPCDQDGKFLDPATPPPPRTQASRHDWTSYADRIQFDTAEFLYQRTQMSQGNVDLLMDLWAASLLRFGGEPPFANVKHMHELIDSTPLGDAPWTTMEASYTGELPANPPSWMTAKYELCFRDPRVCARNMLANPDFAKEFDTTPYREYDGRMVRQYCNLLSGDWAWEQADLIAEDPDTHGAMVVPLVLGSDKTTVSVGTGDNEYYPLYISLGNVYNNVRRAHRNAVLVVAFLAIPKAEKKDRSDPKFRKFRRQIFHTSVAAILQSLKVAMSKPEVAQCPDGHFRRVIYSLGPYIADYMEQVLVGNIVQGWCVTVFIKAIDSCPTPATDLEQPYDDVNMRSRAYTEAVVADMDLKTLWQDYGIVGDLIPFTNDFPRADIHELMAGDILHQLIKGCFKDHLVDWINDYLVLEHGETKGHDIMDQIDRRIRAAPSFPGLRNFKEGRDFKQWTGDDSKGLMKSKHIKAVKEPWRRSNHYEALSQMLLTNQRVDKLAAARTDFKARRMLEGTCLTETLKALLKEMQKNEERELENGETEMMAERASESDSDEEDDDDDAVGILEGPRLLGDVVLARRPDAPLTEDAVTPRCPDITGNVKVFHSAVAMFYAPSDLAGIGGMRRERIRATPSWHRGPGRYDCVYAEGDPTQPGFRGLLVGRARLFFSFKSGGTEYPCVLVQWFSTVGNEPDADTGMWIVEPDFNEDGSRSCGVVHVDSLMRAAHLIPVYGDAVLPHDFHWSQSMDSFRAFFVNKYADHHSHEVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3G3</accession>
    <name>A0A2R6S3G3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3G3"/>
    <dbReference type="STRING" id="98765.A0A2R6S3G3"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="38"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="93"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS36824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33793" checksum="49310A189A167F92" modified="2018-06-20" version="1">MDSPDRTHFLADLKPGGKYEKIVGIFRKNSSAVRIGVFDKEIIYSLAEVGVKWIAHCGAGYDKIDILACKEKDISVSNTPGAVDDATATTALYLMISSLRQFSKAERDVREGLWKSRLSSANAFDMTGRTLAILGLGGIGMRLAELAHVFPMRIVYHNRRKRDDVPDWCEYFPEDRLNEMLGITDVLSIHVPLRKETEGFVGDKMIRALKKGAIIVKTARGKVIDEDAMIEALEDGHLGSVGLDVHPNEPKLNPRILELPQVTLLPHVGTATFDSQKNMELRALNNLRDFLVKGRGIDVVPEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3R3</accession>
    <name>A0A2R6S3R3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3R3"/>
    <dbReference type="STRING" id="98765.A0A2R6S3R3"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF74">
        <property type="entry name" value="AGR407CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="16295" checksum="DDEC46DAF13CC167" modified="2018-06-20" version="1">MLRTYYTVISVANISFRIGLDTGSADLWLISSACSTSECSKVPKYQLDYHSPTFVPVNNNQTAFNVSFADGTGEWAVSVNITSTVTEYFFKAANGFIALETVQVSNLTVAQQGFGAVTSSNITFDDDVSGILGLGFPRLSDISQSISCQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3T7</accession>
    <name>A0A2R6S3T7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3T7"/>
    <dbReference type="STRING" id="98765.A0A2R6S3T7"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="7">
        <location>
            <begin position="541"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS36954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113819" checksum="7BA7BA7E14079BC4" modified="2018-06-20" version="1">MKTQHPDKMKQKSLMSFFGKASTNVTKAKPGLSSPEGSPKASRSSRTLTDRSSDPPVYETNIPLSKGGSQSSTLGSTNYTRGSNEASSSRDTPATSDPIDVDMLSAEEEEPIGKNTKTKTLVTRKRKIVLEDSEDDLQDVDTAAYRKGLSAYQPSPEANEAKSRAKKRPRVSAMLSDDNEDDGDGPVVSFTQRLTKFKPTAKSKQNRKSSMVDDDDFIVPDDEDEDEELPSAFHQPSPMSDVSSRPSSRLSDYAYTDASEAELDEPSTERIRSSKVRPSLSEKNSSKRTSSNLFLTAAEQRAQRQKEEKKGSEDPFEFLVDIKDKDGIRPGQPGYDPRTLFVPPRAWESFTPFETQFWKIKQNHFDTVLFFQKGKFLELYEDDARIGHQEFDLKLTQRVKMSMVGVPEQSFNFWAAKFLAKGYKVGRVDQAETALGAEMRVAADKGKGKGRSTNTENKDKIVRRELNKVYTNGTLVDEALLTDDQAGHCISIREDGEEDVKTGTQKFGLCVLDSSTSEFNMSAFEDDVCRTKLETTMRQLCPKEVIFTKGNLSVSTTRLLKTVLPEKCLWTSLRESEGLSYEKTMKELKTLYPDGGEDEETDDDMHGLSSAVPEAIRSMLMYHGAVEALGSMIWYLRTLNIDKDLLSMKNFNIYDPMKKGEGLVLDGQTLAHIEANGSFVSGSACPYGKSQTSMPGDLDAVQDLIDHPTFESEFTEVAKGLPDLERIVSRIHSKNCRVKDFLKVLEEIYLVQTKPTDDVPKSWVKSGATKAAARWMVPELAQSIRSLKEAREHKNIAIKEFKNRLYAEFDTDRTVWLRAIRVLSELDCLFSLAKASNALGEPACRPEFVEGDSAWFEFQELRHPALSVSAGFRGDFIPNDVKLGKDVGRIALLTGPNMGGKSTDGMAIAGLVFLYKLVKGVASSSFGTHVANLAGVPMQVVERAETISRDFAHQFKEKIEGKKKDKAVCTIPLVAQADFAFLYSLATGKRELPEDKMRRREVLRGIRAAVRSCLKQSHPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3U2</accession>
    <name>A0A2R6S3U2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor CWC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3U2"/>
    <dbReference type="STRING" id="98765.A0A2R6S3U2"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34618" checksum="657D0147026C7516" modified="2018-06-20" version="1">MSMKAYLAANYMSGPKADAILSRTSEPVGKKKKKRKVGASSSNGGPSFIKDDDVPGWGEEVQDAEDETAEAVFAEDRGFKKRQRTDESSGWATVREPTPPLPADEQPQVVVEEDTPFKGGLLTSAQLKKSLPKKSAQQEALSREEIQAAQETIYRDATGRKIDTAAERAEAAKKKREREEQEAKKMEWGKGLVQREEVEKRRREEEAIKNQSFARSKDDLALNEELKAQERWNDPAAAFLTKKRSKGPKKPEYAGPPPPPNRFGIRPGYRWDGVDRGNGFEKKLFQRRNDKKRRGMESYEWSVDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S532</accession>
    <name>A0A2R6S532_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S532"/>
    <dbReference type="STRING" id="98765.A0A2R6S532"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5782" checksum="111EB425FFCA5BA0" modified="2018-06-20" version="1">MALIPPNPGTDLLDVDESEVCRPEHCFYAFDTLFCALTSYHPLPPQFPDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6P3</accession>
    <name>A0A2R6S6P3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6P3"/>
    <dbReference type="STRING" id="98765.A0A2R6S6P3"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="457"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="499"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="545"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="629"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="671"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="713"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="755"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="795" mass="86323" checksum="AA75FA810C46C322" modified="2018-06-20" version="1">MSFAAVYAKGLSTAGHGLPLWHPEPSENAGEVQIGDVGFIHGGAFYRLFNVLIGRDAAVTVDEDEPPATLTYNKKLKAEFPRSLKPGAYMSSSVRSTQLIGHAAIPVAPGADVGLTWSWESTKTEGSILVLQDFGREEVVARSKAFEQYLLQHIDSWYQYATDVLGVVCKPEELLLVHGWIKTTSWNLGAFQSQTQSVGVTISGNISAVAGIGLGLEVTKKNGATFEPRSSPQIASTASLSALATNIINANTSPASSTMPAMLLPELPQNQCVFLSAYRLKYRIPKIWRTVAAAAGYDQLPDADDSDRHDPSATNDSMEREVETEGGPPTFRGPCDILLDYILNNSTAHAAVASEASLSDLLAGKEWPDDLETFLNELCPAIEIDENGYGTLSFEEEIRRTRIRETDYVPDDLDDRAIMRMHEACDSSDRQVLENGKLFLDGSSKPVTWSHIILANNQAEMGSVSAVAVSSQGHHVATGTEDGVVRIWNYKSGKVEVRLEGHEEQVCSLAFSPDGTHIASGSGDFHGMIWDLNDDDDDYAPLHVLEGHDGDVCAITYSPSGTLVATGSMDYTARVWKASDGVHLFTLGRPHTASVLLATFSPDETYLLTCSNNMGYVWDPYSGSLLRTLQGHTDAIWSMSLSPDGQRVVTGSEDLTGRVWSVETGDELVTLREHTGGVWSVGFSPDGKDVVTGSYDSTIVTCDSYTGERRHIFQERPAIVNAVAYSYSGDFIASGSADGCVKVWDTSSGAFVAEFQGHRDKVKSVAWTRDDLNIISSSDDGSVRTWNMRDMLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6P4</accession>
    <name>A0A2R6S6P4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Topoisomerase 6 subunit A/Spo11 TOPRIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6P4"/>
    <dbReference type="STRING" id="98765.A0A2R6S6P4"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="2">
        <location>
            <begin position="142"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="377" mass="42472" checksum="7ED2E9D8A34EC344" modified="2018-06-20" version="1">MHVQDFEVLDVDMWEDSREASQDEGAELHEGSEPSEDSEPEEEEASRENTIKLLEDMVVDFLEQLSDALPSADNPKPKKADNKKVIMQLADRRKPVKADGDMFYKDVQLFGNPFDFSSGIKGTLIPPSEEISRFEVSEDLSWVLIVEKEAVFQTLCHLDFSSHPSLPGPGVIITGKGYPDVATRQLVCTLSNNLSSTIPIIALVDADPYGIDILSVYKYGSTNMSHEQESLAAPRIRWGGVMSSELAGHWQCFKDRTFQRNGGTFPHKTYPAQPLQSAYRSFALICDTERCDGDRKELQYMLHNRRKAEIEVLSSAPRKSIKRNAREEEDDGAKSADEQPTCNVTKKSRIKTQECILVQYLLTKVTKAVNDCRRKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6V6</accession>
    <name>A0A2R6S6V6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6V6"/>
    <dbReference type="OrthoDB" id="3184377at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS38030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="23060" checksum="F7394156FBF888D0" modified="2018-06-20" version="1">MASVTAVVDAVSSSEAASLHGYVVSLSLTHNDQRRLKGQHRHKALTPMISGIISGSCVGIAWIIGFIIYFYKRHRREKRARALGFKNHREMLDPPKKPEAFIIPPDPAVVEGGRVPGERIYNDPGVLDSDLPKHAKTIPFAHLEKADEKTESDESSLSPRGSGVPHAASAPSRVPQKTSNQTATASTAHERTLPSPASPRRISSEMTIPQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6W4</accession>
    <name>A0A2R6S6W4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6W4"/>
    <dbReference type="STRING" id="98765.A0A2R6S6W4"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="244" mass="27430" checksum="E9D380810B74ADEC" modified="2018-06-20" version="1">MAVFYDEIPDDERLVEWVKAQKIFHVATAPLKGQPSPTGRVIERDTPEFDAILQSDNSDDDKSIDYPTPEMLPGVRAIIWLDITKVGSSCGYSVPFMQFIAHSELTFFIDVKFIWRLYSVEGNALNDTMNYREVNDEHNDNPFALHHKKGLQSYWVFKNSWSIDGLPGLRRPHIADRVTPDVIKSAMAECGLKFDAMKSGRGRAFGSYGGVLLGIFLTLLAQRVMGLLAGRFTDICIANHCLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Y2</accession>
    <name>A0A2R6S6Y2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Y2"/>
    <dbReference type="STRING" id="98765.A0A2R6S6Y2"/>
    <dbReference type="OrthoDB" id="9922773at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="166" mass="18641" checksum="C81CC5BFA9252428" modified="2018-06-20" version="1">MARLLEKHPVRSCGACDELAKFTAEPIGNALVNASITDVPHSLILNLNSLNSMLIEIERRPDAPTRALSFRMTRGEVLTRDDFTRGIMKGMRSSKEQIESWTRNSRGDPSHTLQICIIFEKHIRCIWASFTEGDLEACRAVDKQEANMVAVLWEEALKTKIDSGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S780</accession>
    <name>A0A2R6S780_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000001">
        <property type="protein sequence ID" value="PSS38147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S780"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="84"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="216"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS38147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="476" mass="51787" checksum="A5DA4EB12D99B44D" modified="2018-06-20" version="1">MNSVQNPVDEIRALSDLIKSSIDKIEESCLSRGQIYPSANDPFTPQSEAARMAPDVQEYGSIVVAAAAQLIAATRPPPLGLATHALKFHVSSCIRVAINLHVAEILREGGPLGVHVHDIASPTKVDPTKLARVLRLLATNHIFLEVAPDVFSHNRLSSLLDTGKSVTSILADGDAKYDNTLGIAALFDHFGDEAVKSSGYITETLIDPKTARSGEPNQTAFNRAFKTDLPMFHWYDLEENAFRRRRFGIGMEGTQNVVAPDAILQGFDWKALPQGSLIVDVGGGIGSQTHALAKAFDHLSFVVQDRDAVIEEAAKFWNEKYPEAVKLGRVKLQAHDFFEPQPISGPSVFFMRMIMHDWSNDYCLKILSHLRSAAAPSTQLVIIDNIASYACPDTTSAQQTPGASTRLPPAPLLANKGEANVLAYLGDIQMLNLNNGSERTIAQFSELLRKSGWKLVRVAQGDGFEGENSKLIGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7A1</accession>
    <name>A0A2R6S7A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v40</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7A1"/>
    <dbReference type="OrthoDB" id="2984821at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="15103" checksum="7E84DCFB6247913E" modified="2018-06-20" version="1">MWTNIELAINFLLSIKQPLTVPNVLSAYIEVAGFRSTEDAVVAFEHALDKHPLPLNYEPQGTVYHRPFILEVDHIRRDYWKERLGDAANCTCDECGNPVLDHCLDVTVDYSVTLDYEKTHEQKSRGTRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDV9</accession>
    <name>A0A2R6NDV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDV9"/>
    <dbReference type="STRING" id="98765.A0A2R6NDV9"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="431" mass="46687" checksum="AAAA7C576F2BB54E" modified="2018-06-20" version="1">MAAEADSKPAERKYSAEEKKQLLANLDLEVSHRAQQFESWLADALENFRVHQESHISRVPPLVRNITMREFAKYNGDIRACLRALNRERLGGEAEAIDKTTRKRKWVESQEAELKVGSNTGDLDAESSKGVKNARIMTATPKKAGPSNGVGTAQRARLPLVKTPATARMMQRIPSRAPSPSPYKPGPSRHPIPFPRLNSRPPSPSKLPSPSKPSSSTTHTLNVRLPSVPSFNPAISSASHPRWPRRDESMLSANGSPLANPLSLDLSGWLSKVTEVEGEEGGGSEHSVSKANRNRTNSIIVRSTSSNGLHSRTNSQTTIVVASQSQSNPRTNGFIPTRTPRATPPQEDTTLSDLGPSLPSLTALVAVPTQDGHLLEFNPFETTPGEIDALEGISDGAKKQAKEDMARLVMQAYLKTCGAADDLVPVAGFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEN2</accession>
    <name>A0A2R6NEN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001314">
        <property type="protein sequence ID" value="PSR70806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEN2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="5475" checksum="500E4723ABB6D978" modified="2018-06-20" version="1">MGEELDHGGPAEELEVDDETENISGGVQADDIEAENTSGSVQVEEAAVSETAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NET0</accession>
    <name>A0A2R6NET0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NET0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6644" checksum="BFDF5CDB9DBFFD8D" modified="2018-06-20" version="1">MHMVELWDLNIHIRGQNVVLPGGRSGAGTPVHSPAVGRRTSEVAAWAGNQNIEIEMLEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEV6</accession>
    <name>A0A2R6NEV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v13207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001304">
        <property type="protein sequence ID" value="PSR70893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEV6"/>
    <dbReference type="STRING" id="98765.A0A2R6NEV6"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="96"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="369"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR70893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="601" mass="64970" checksum="929AA0147E46AED3" modified="2018-06-20" version="1">MDLTHSLNQLSLECTRLWSVSWDTFVTLLDDSSSGENSDDKFGLKLQVSPRGVESNVSSDAYGSVGGLDKQIAEIRDLIEIPLTRPELFRHLGLKPPRGILLHGPPGTGKTHLARAIAASTGSSVIIINGPELSSAYHGETESKLRDVFADARSKSPCIVVLDEVDALCPRREDGPGGEVEKRVVAQLLTIMDGMAGNQDDGKDRVVVVATTNRPNAIDPALRRPGRFDREIEIGVPDAEARSSILQVLLAKAPHTATQEEIYSIASRAHGYVGADLSAVVREAGTCAIKRWLSAHPDPPHIQPEITANDLLTALLSVRPSALRSVFFDTVPVRYSDIGGQAITIQKIRECIEWPLLHPEAFARLGVKPPKGVLLYGPPGCSKTLLVRACATESGVNFVAVKGPELLNKYVGESERAVREIFRKARAASPSIIFFDEIDALATSRSTSDSGGSHEGVLTSLLNEMDGVQELVGVTVVAATNRPDVIDSALMRPGRLDRILYVGPPDQLGREEILRIRTKKMSVEPGLDIAEIARITEGCSGAEIAAVCQEAALITMKEDINAPHVTCKAFSDAARGVKKQITPEVIVHYQRWREQNGVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEZ3</accession>
    <name>A0A2R6NEZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001301">
        <property type="protein sequence ID" value="PSR70933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEZ3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6820" checksum="D986E673E7A0D867" modified="2018-06-20" version="1">MDYFQYSDQRQSLVQMELANRGCTVSRPSILLLGCQNVDFHVGGGHCNQDILRVWTFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF40</accession>
    <name>A0A2R6NF40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001342">
        <property type="protein sequence ID" value="PSR70632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF40"/>
    <dbReference type="STRING" id="98765.A0A2R6NF40"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="69378" checksum="79B7A41595BAFD0B" modified="2018-06-20" version="1">MHMKFNFLNCRTSKKRGSLDVLNNDILVDSVLCYLGIFDILRLRRVSKLYYDITHHAVLWKRLLHACELPLPPLPPTARHSLENLTALEAERLLVRAHSLDVMWKHTYPDFLDEWEFDSFHRVTQMVLLPGSQYLVASVADTGGSNWSIIVYVLDTRYNVIPIAKTPTTTKAYNLQAKYLTINGVLGITITYVRRDWRNRRDRRKGIDVSDYSGDHDIDAPYPLKYECHALHAPLKELEVLAISRLVPGSPEFLARAAAQPPPFAQLCMIRSTRALGSIVLDEVEDSPYLTLIRYPSSIMFKPLNGGPVSILNIENFGDFADYPHQIKAIRPLPQQRQILVAREIRMPPTHHRYPVFSLEFHPIPISMTSDPQEVTRSPDDFAFFSEDHYSNVYITDHGTQNWLDESIQGEKLGGAEYKAFKPRPINVLFRAVAPQEGLLRMTFYPRRLDNWAPPSPTPSISSSSENSSLKSIRPKYYYRYDRTHVSPVRFVAAFEGSQYRILPGSYRTLLYSVPWDTIGENPTVLGFYRYHDKEIFADEPEATTEESMIRRPIYTLPYNFDQNLKFGAFAWDETIGRMCYGIQNSTKIRVCDFTKRPKEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFC7</accession>
    <name>A0A2R6NFC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001297">
        <property type="protein sequence ID" value="PSR71021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NFC7"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051685">
        <property type="entry name" value="Ycf3/AcsC/BcsC/TPR_MFPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943">
        <property type="entry name" value="CELLULOSE SYNTHASE OPERON PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943:SF8">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN MJ0263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1468" mass="163573" checksum="39EB0EF8FCCFABC6" modified="2018-06-20" version="1">MAQHLNNSLRTTQKWDVRDDRTTAALVKCRKGLPLLRPDHPMLTAVLLVISKALSRRFEALGEIADINDSIIFLGESLTISPSSQDGSIGDENDLHAAARSLNILGDALTSRFMHSKNSEDVDAAIDNYRMALALSSPDNPTHLQRRMYLARVLFLRFHEHGRREDVDEVIQLEREFVSSSQTAPDEDDTYGSLALHFYYLGSLLKIRYTKFSLIVDLEDATESYEKALALLPNNDERRPDCLRGLAVSLLLTFEAKGQIGDLDGAIGRVREVIACLSDGNIPLDEGEIVESLAQDLNLLGDLLISRYLKLGLIVDLEQATESYEKALALLPNNDERRPPYLRALAVSLHLTFNTKGQIEDIDGAIDHLREAIACLSGENDLLDEAEILGSLAQNLNLLGDLLISRHRKLGLIVDLEQATESYEKALALLPNNDEMRHPYLIDLAVSLHSTFKAKGQIEDLDGAIDRMREALACLSNGIDPADKGETCIFLGFLASILDERFRCTGERADLDEAIQCQYQSMELNPTKRYSALDNLSAHFYARYLNTGDRNDLERALGFSREALELCPVDDSSTRLQIKRHVALYLDARFERSDRAEDLVEGLKIRRELVALTKGKDGHHEDVKYLADSLVSQWRRDPGQLGAFDEGIQQLRDVLPTAIHGPARIDLLERLAIFLHNRYLGSDAPEDLEEAITYLRELTVLVPRGYKPRAKILSHLASALQYRFKLFGRSEDIDDAVDSARDAVKITRSSHGRDDLVECLSILATCLYPRLHRDDNPLGVIEEAITVQQEVVSLSPDDGPALRNLALIILERQKRLKQSNGIEEAIILLRKSLALIPAGHPDKLWSLDALAEAALWRCYLSGGIEYQEEALDICHESVAAQRQLASDKSYCDAVGNLAEVYWIKGDYEEAFTRYEHAANMRYATPRSRFRITARWASRAMQAGHSSSLRANTKALELLDQCLTSTPTIDLQHQFLTRNPGDFASNAAVCAIEKEELEIAVQVLEQGRALLWSRMRGYRHSIEQLQESNPGLAEEFKGVCQQLEHITVSSEPNLSGMAPISVSTPPYAAHGLDFDAKVTKNRQLSDDYERIISEIRHIDGFSSFLQATPFSTLQTAAREGPVILVNVNEHRSDAIILQATEAPLLVPLPENLFAMVDTLSSRLVVVDRINRDEDRKGVARQPKQLDMGNILQLLWESVCQLIALALQEMGHPTGSRVWWCPVGRLNALPLHAAGIYNNKGVLIEGLPNLYVSSYTPTLSSLITSRETAVKGGSGPRLLAVGQSNALPKVKDELFKLKNLFPSHVLRVRDDDRAQADSVLLNLRDHSWVHFACHGSLDASSPFKSGFMLHDKKLSIRNIMQAKLPNAELAFLAACHSAASESMSKTPDEVLTLAAAMQFCGFRSIVGTLWTMSDNDGPVLAEKFYKHMLRNGLDHTDVRDSAEAVHLATKSMREAGVPLHRWTTFVHVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFE0</accession>
    <name>A0A2R6NFE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFE0"/>
    <dbReference type="STRING" id="98765.A0A2R6NFE0"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="473" mass="51018" checksum="9DD49ECD5D5A4105" modified="2018-06-20" version="1">MAAKDFTHILRESRAQRKAKMAHRSNNLPSEQRTKNKKKKGKSGSSKVNGQAPADGTSTPPSIEGPSIDGPDGELLLLHPSVLPDAPDPIEPQCLFLRGAAYLQHAVYLIEEAILKLEGIRKEPTADGAELRLCYVENGRYGGVEIGNPHGPLGSNDGEKLPAYKQVLAEDNFREQIITLIRKSLRDHERFLAYFDTLEGPAIDPAFDVNPSQKAEHAFLLSQSFRPGSHIAPPPPLHPDTPVMFTTYHPLLVESHFSILICLIMLGDFPSLLPAFYRAAMLVDGLEGYPVFLPPRSMAQAEFIEILERLAGGWRNGIQPHSMVRSTSFALEVASRSAKAKEVDRSPMLLPEGSSASGSAFATSLGINGSSSSSSSAVRASNPPSGRDTPASNEGRVDLVEALDCARMLLVPVAAKQKEKAEKAAAEKAAEKAAGKGNKKKPLSINIPLHGPRVEIVLAWLAAVHLVELDTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG01</accession>
    <name>A0A2R6NG01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG01"/>
    <dbReference type="STRING" id="98765.A0A2R6NG01"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="881" mass="96459" checksum="FA63DDE157CC4371" modified="2018-06-20" version="1">MGEASTLSVHRCRFVDFTPSAITALAFPPLPLPSLKGKKSAVVQKALKVGTLAVGRANGNIELCEWSASEHDLQAPQGWVVRKTIPGPFQSNVDSLAFTLRNPDQLSSDETPSLADLRLFSAGGGSELAEWDLERLCIRRTIPSQGGSIWCISPNPASTVLAIGCEDGAVRLLSLEHDTLTHLRRLDRVKSRILSIAWGPPVPRDTKNFPKPDEDSDDDDEDDWKDSWLVAGCSDSSVRKWDVASGRVGDRMGTDKMRGERTLVWAVGVLGDGTIVSGDSLGMVKFWDSRTSTQLQTFQAHGADVLCLTISPEGTAVYTSGVDQKVFQFTHVKTQQAGVTESSLLSRSPSRWVQSVSRRLHSHDVRALAIWPPYSPLPAPHRRQFPLDIAPVLASGGLDMSVVVTPAALPASTMTKVINPLSTSNVATYEDAYHRRLAYSSGPFNATALHLARQARLLLCMRDSSISLFKISPKKVPATSEDGSDLPELSEGGWEPVLDMDLNVNTNLVASAISDNGEWIVVSDWYEAKLFHMETLPSGELKPTRIKDFASILQAHLPNTPASTGASSFNFTPDSSKLIMTSAMSAYVLVIDLTTKPRVLRRFDHHRMRNVVLGDRVMKGRKNSVVGEDVEMADAGGAAGSDESDADENVLLAKPFVATVTRTAVSPDGQWLATSDDRCRTHVFNLDSIQHHCTLPSFPQPAHALSFDSTSPSILVLGLANNTIQVYDVESRTFPLWSRELTNCLPQRFTHLHDTILGVTFDLGERAVPRSALFWGATWLCRVQLDAGVGWGGFEKKRRWGGKRISTRQPKFSLATGPNLVSLTEDTAEKTPQNFKMVTHYRPIIFVDFIAPSELVVVERPLVDVLAKLPPAFFKPKYGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG23</accession>
    <name>A0A2R6NG23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG23"/>
    <dbReference type="STRING" id="98765.A0A2R6NG23"/>
    <dbReference type="OrthoDB" id="2755676at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015322597" evidence="2">
        <location>
            <begin position="24"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="243" mass="23671" checksum="89BA1801C13F6BB5" modified="2018-06-20" version="1">MLSPAVVISLFAVSALSPSIVCASPVPSMTHHSNTPATVDHHRAGNNIAPRGLGFLNEVFARADTADKAMPTSKPKVLSLADFNVGPREFWKKSVASTSMNGKRDAGSGSSGSGGYIHHHSKRLDDGQTAGGNAHSGTSGAVDGGNVDSGDNGGMPTLMNVNSNNAGSGGGSSTGCASGGKGAEGGNASSGNSGTAYGGEVQGSGGMMNIDSNNAGDAGESSSGCANAGNSALGENSETSAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG29</accession>
    <name>A0A2R6NG29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG29"/>
    <dbReference type="STRING" id="98765.A0A2R6NG29"/>
    <dbReference type="OrthoDB" id="3268787at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="336" mass="37927" checksum="36DB282524C72EF5" modified="2018-06-20" version="1">MSPSLDVTLKRHPSLYFEDGDIVISVAASAESVQLFRVHHIFLANSSPVFRDMLSLPAGTEKESSAHVNEQYDGVPLVHCQDDPDDFAELLHVLYDPSMLYTMLEPVYYDTATVLVGLMSLSDKYCMDKIKAAIGARVMKDWPTTIDQYDNAAQACMNYHPGRLLSMAWDFVFPEPVAAIEFATKFNTPEILPAAFYHLATLDTSIKWTGMEYKPAGRWSELSSQNVARFIIGRDKLYKATVASVLGVFDEPCEYAVCDTARAVRRQDVIATTFLEANVTQHMDPLRIYNQLRENIGFSDVCVDCQFRIAHRLSEEKGVLWECLKVFFDLPNPQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGM7</accession>
    <name>A0A2R6NGM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGM7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="11130" checksum="905D68F5AE9FE443" modified="2018-06-20" version="1">MALGDGINRVYEAIMYKHSLDDIEFQIQLYKPEEWRIEDTVSRLVEMQSLQNTRSSAIHEIQGMETNPEGFGEGRTITADIGIGAMSCGGLDCRFRSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI22</accession>
    <name>A0A2R6NI22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001229">
        <property type="protein sequence ID" value="PSR72009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI22"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="13327" checksum="3BDBC9B7D534F4C8" modified="2018-06-20" version="1">MSSSVNASVNPFAVLLERSPTRELHSVHRQNRDGTQLALLRDESIPLLCDPILSEIVANDPADLSLDQRHNLTIWTRPTPQVRDLVVHIQDRLKEAIGEAKGSKLSKTNNKGLQLIYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI57</accession>
    <name>A0A2R6NI57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001222">
        <property type="protein sequence ID" value="PSR72064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI57"/>
    <dbReference type="STRING" id="98765.A0A2R6NI57"/>
    <dbReference type="OrthoDB" id="2642524at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="569" mass="63120" checksum="B4D075BA7AB21533" modified="2018-06-20" version="1">MDVSNSEEPWYLTIVRMQGIQFIRPAKSWRPIVSVTMVDREQTLPETVLGCDGQNPNLKIPISLHDVDETTRLDIKVWHKPHSKKKSRKRHLIGSAFLSLGGALEGQGHIGSDLSLQLKLPQAKMRTFTIRGTRQSNCTALILRLRSPQDHSKLESPSSSTLISPSSRCDEEFSDDGTDLTGLQTPTEPEEPWECPENILPDSSISGLKKRRRRPKIRGYCVGSSDEDPDVSDVSETDYSLSRPPSPPHMNFPYIQDIEEDQPWDPTTVDPMHHQWDTGSACEDSSPQIMPILPQHTGQVGENEESLSLMEVILDKFSPYREMSDPLCDSGVVLRRLLTEWYAVGASLLALATLNAAVFGYSAGTLYEIDGFALRSVTFGSITAAIGLVADVWFLFLYSSVDVAKFENRARDVYNGYLFFCLTCRFPTLCLLVSTCSLTSFLLVVAWDAWPTAVLIMCCAAGTFLTLQYLIFGCHRAVNFIIWGLQGLCRWGWSLGSGGTGAQNESHPSLIDDILLAPLSDKTPRQTCADTARESLRRLLPTTSTPCIHSWVGSHIGFQSVVGNPSVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ11</accession>
    <name>A0A2R6NJ11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001193">
        <property type="protein sequence ID" value="PSR72356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ11"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ11"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="227" mass="25747" checksum="CB6CF42E3C6462A6" modified="2018-06-20" version="1">MSLKDVAEESFMVKFGRPLFWSRLENSEEVDRVPGNIVHFARIKLIGRSNILPPGVSLLERRHNGLLAAIGTRILFEFDTSREESRTREMQLVEGHMRIVYSIPVDRQYIRSGYPSEPILAEAAAHEMNSEERPIINILSSFIDNGLIYKGGGLVARLILAQAYDKAIQTSHPQPWKYSQGVTVAAFFTALISEKYIGRWQDSAKGGFQERVHSFHTLCSKRQGQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ44</accession>
    <name>A0A2R6NJ44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001224">
        <property type="protein sequence ID" value="PSR72032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ44"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ44"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR72032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="44028" checksum="D169BDB78B6F29B9" modified="2018-06-20" version="1">MAIETASLPLPPSADASKFAEFGREVKGVNPGTLTPEQFKEIEQLLYKHSALLFRDVDLSPEQQYALTKAFDPTSESYGHGNNKTGETKKSILHPDLKTIPRVPQVQLIGNGTVYDHEGLAEAKLKHPSHKSFHKTRVSDEDEAKGVTRFYRWHIDAALYDLSPPKVTTLYGLTVPRGDKQVCRYDDGTGDELEVPLGTTVFVSGKTMFEILPPELKSLAVRSKVKYSPHPYVWMAPAHAKSTGLGIETEGLEMPRDELPPWEESKIKVYPVLWKNPVTGGLHFQVHPCGVSEVFVDPLPEGAKREGALYPDGAHLTNLGEVRELLYKMQRPAIAPNLVYPHDWHEKDLVLFHNRGVLHSVVGAFAPNQVRAFHQCNLAASDDPVGPNAEDVKQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJQ8</accession>
    <name>A0A2R6NJQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001152">
        <property type="protein sequence ID" value="PSR72610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJQ8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015345628" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="6015" checksum="EBB70D41982B5B23" modified="2018-06-20" version="1">MLFHRIIASVLVAVSAGCVCQARPGFIKNAAAREIEMTEDFNVDEWEKWGQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJU5</accession>
    <name>A0A2R6NJU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJU5"/>
    <dbReference type="STRING" id="98765.A0A2R6NJU5"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="412" mass="46916" checksum="BD7F2C80CDEC3BA4" modified="2018-06-20" version="1">MIDTIDTVGDKICMFGFSRGAYTARALAGMLYKVGLLPAGNIQQIPFAYDMYQREDEAMSKEFKQASCRSVHIDFLGVWDTVSSVGLVPHHFPYVHENRAVRYLRHALALDERRVKFIPQFCTDPPSDTAVNNAKEQEKDNNAEKRAYTSPMSDVEEVWFTGVHCDVGGGAVINEKTVKLSGIPLRWMIRECFKCNTRIVFDAAVLRKLGLPVYVSGETGNPILAPLYEVTSLPYPSPSQETPTPQDNLEILPADYELRRDLDDARDDLHDMLKGSPMWNILEWLPLHLKKEKALASGAKGRDSYRWVWNRGKGRKIVKREIQEGWKVHRTVLLRLHADKDYVPQACPNIPIAKNPQTNRDKTREADVGRATKSLKDPRRLDHDEWRGLEWIIPQDGSAWTLVNPHKTKKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLC8</accession>
    <name>A0A2R6NLC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome activator Blm10 middle HEAT repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLC8"/>
    <dbReference type="STRING" id="98765.A0A2R6NLC8"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="2">
        <location>
            <begin position="177"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="446" mass="48982" checksum="80DD3EB914CC691C" modified="2018-06-20" version="1">MASDPRRIEEIPDDERSEDEGRPRWSKEDLESKWRWPGLYKDVGIFTDREWSLIMCKCLASMEIPLADSGSLTTGPSADNQAGFELNRLPKATWRIPSLARIIVYSMSPDGIPTPASTAPTPFFTPTASGASTPLPHPHSNAGLAGALADYLSAPLGKASHLKSKTYLGGSKALDSLSKFIASTEGFFHPTNSGNWTNDLSAFVKYVVFDFNKRWHDEQQPDCKTPTHRRLTRTMKRELVNSLRTVCFLAMFSQDNTTVSNIQGALKSMCILEPDLILPSILERAGPALEALVETQRTIAVIKALGAVAPAMVCRHIYYPGAKHLLPIMELLLPGIDLFCTTAFIVEVSQYVKFGELTNPEDSTNVDIDTGLTGPPLPTVEFRLPSKMSFGDDADYSKDEQDTLLITMSEQIADWVAAFLRRVILLFENLPEEGANGAAGGQTEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM14</accession>
    <name>A0A2R6NM14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM14"/>
    <dbReference type="STRING" id="98765.A0A2R6NM14"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="355" mass="39894" checksum="46579653DC6BDAC2" modified="2018-06-20" version="1">MSSQELSFSQGPVATGSQKPTAVPPPSLQQEDSIIHTRITNDEKALRRVTKKFHNYTSVAYDPVVPPSPILTTSVDDARDAFLVELASFHLSLKKSLMVCEAEARQVEEYQREKARIENEHILLRSQIDELKMSLEQAQVQRRRKMEYDLIAEKINALPSREELEQSIRVLENDMHAIHAEHEDQNRVLHAQQAALGVVISNIQDLRLMGKQDVEVAEASRTSSPAPDTQGGEPADVEMETDTREETGEIEDNKEEGSNERDSDDDVPLSKKHLNPSARSFLPHSSSSRLSTPHLEGTPPSTRAYREEGEDDDIEMGELAEEPIEKLIKKKIREEELEEGEASDMSSELSEPPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NML8</accession>
    <name>A0A2R6NML8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NML8"/>
    <dbReference type="STRING" id="98765.A0A2R6NML8"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="90"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="335"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="628" mass="66827" checksum="5099CB6E8D7BE8FA" modified="2018-06-20" version="1">MADLYPTYGRQYQRQDSSHQGYQLAAGSSSSGIMYPPQLLTQSSIVDDHSSANQHDSNSQSPISQPNSSPKQESPTASKPDGMPQQPSKPQATFLTKLYALLERPENHHMIRWDPAGEHIIVERPEQLALHVLPSVYRQSRFASFSRQLNIYGFMRKVNLRNVDPAIDDPDASTWSHPTLNRHSPPEVVANFKRRVPPRLPKPRKRDPNSEMPNIPPPPRSSGGMGPVPLSVPSGPGSPGRRSRGFSAPGSFTPLSQPTAPGWSTAGYPRSALPPLTVPDAHPSSLSAHGHHMYPHPHPLTPSDDPPPSSTSAFTPLSSYSSASAGNGRADMLLPSPSSGYPYSEQSSWSFSPGGTSSHSSGSLSSLLNPNTSGGAGGYGSRASTSLNTYASSYPTLPTISRNHPGGASPDSRPATGYSVSSISSMSTPYEETAPHHFGHDYSRPGSSHRPLTPASSRPPSSKASYGGPNSLSVRRDRRHSHAMSPYPSPYSDHPPQSAGSERPSTSPHPSEDHHGVNGMPRVRSMMSMGAVSDAYGFNPAQADFAYGAVDDHQSSVAHHGHGLYGRSVRPSTSASSLSGSSSAANTPGGDGYGHGGVEGADISRFSPDFGYVQMNEHLPHYSKAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMY2</accession>
    <name>A0A2R6NMY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001068">
        <property type="protein sequence ID" value="PSR73710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMY2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMY2"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNF598/HEL2 C2H2 zinc finger" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="ZNF598/HEL2 PAH" evidence="2">
        <location>
            <begin position="139"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="444" mass="46813" checksum="8E011ECE4A9686CF" modified="2018-06-20" version="1">MHTQELHFTQGHYPCCQPVCLVRKFVVFGSALDLKAHMVEEHGADMSSRDKKDARRIQAEFGFEEVPGGGRRGGRRDRGDREREREPPPSAPPRPNAAGARRREAFSGNLTTDNAPVTSSRIPSRQQTPSPGLDPAVAERHTAFLARVSLVASNPNNAIPAVKAAVRSYRTNESGARDLISTIWNISDRNLEGTAGVINSLVELLEDEDKKKDLLQAWNGFKIEQRNQFPELVPSGTGSEWAGITGGRLLNAKQTTASRSSAQSSRQVLDRVARAAASSSHAGSSTPPRAVSSTDMFPTLKATATVAGGSSRQGQRQTPWASSSAAAPAPAPVVRGPTSVPGPGAQTKTAPPNLTKAAFPELPMSATTRVPRAAVGGNQSLRKILGESAPPAPAWGAGGTGNTNGAATPQEGTNTESAAESSNRGKKGKGKQKQTLFTLGSFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMZ1</accession>
    <name>A0A2R6NMZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macrofage activating glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001067">
        <property type="protein sequence ID" value="PSR73721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMZ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NMZ1"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015362139" description="Macrofage activating glycoprotein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="38958" checksum="64563A534EFA98EB" modified="2018-06-20" version="1">MSAVALSALLAAAAASVVNAQTQQFPATPLANKHFAYPSGIPYQADTDDLLRGTQQGYNLCNSTTEGQSSLCQTAFVNDASDWCVWAPPNGPSTIGDTEGEEVAWCTKPGRGTRLIPAGAITGVQFVRSPSYLQVIAFMDQTKLNLEASDFGGELDPHGADLRGNPLGGLMYSNQLPQSGTGDNSTFTQVIEWHNFIGSNHTCMKVCDPKDPNAADYCQHVFDRIGVQYTCPNAAQDGVFEMCDSDNQEYPGVYTSDGQTLTYTQPAESLGPITSMPYTAVVPASSNCVTFQSADLFSALPTISGAAAATPTASGSNSGSVAAASKGSTSNVASRSGSSGSASPTGGSTSQTGGAHTLRTSAFATIAGVVFAVAFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNB8</accession>
    <name>A0A2R6NNB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001051">
        <property type="protein sequence ID" value="PSR73891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNB8"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="358" mass="41375" checksum="DB78A6E0A687BE6E" modified="2018-06-20" version="1">MSFNFDTKQFVTGSELTELLFCGGPNDYAALIRAPRRPRKPEFLKIAEDMYFKTRKRRQEELRVPTVQDLAFASQEIVRTILANLDDIMDIGHFSLVNTFICNCGLNHINDIQETINAPWLGGRLVCLGNVGLLDCDFPPSLGPRIEELKDEIRRELSAGDPPSQDPEQNVACERDDPVDDATLLDELRYDINYAWEHIQYPTCPDLDRLKRTWIDRRACRHDPHRKQLCDLTSISFQDPKYRRILCNLSKREYVRESALLELSANWDSLSFITLGEVLICRVSWSSSDVTHLPDGAEELKLHRGVWAGDRFKIIAEDELKSKDMKEWKDVTDDVVQEVDKIWSYEFGPNWRVGSHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPQ4</accession>
    <name>A0A2R6NPQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPQ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NPQ4"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="168" mass="17873" checksum="D010306A7CAF598F" modified="2018-06-20" version="1">MVELVHRINATVADSFVGRWFHLEGSGHPRERIGSRFLTEIRAGLTTWAAMAYIISVNASIIADTGGTCVCTSTTDPVCNTDAAYAACVQDVHRDLITSTAAVSALASFLMGLLANLPVGMAPGLGLNAYVSAHVISQMNSVPNSIWQFTYSVVGYVDILIDIDGSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPW6</accession>
    <name>A0A2R6NPW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPW6"/>
    <dbReference type="STRING" id="98765.A0A2R6NPW6"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="171" mass="19274" checksum="386EDB62C9C62582" modified="2018-06-20" version="1">MDFDLESLVNVEQSFYDEGYKDGFAHGRIHGLIEGRALGREKGFEMWEELGFYEGFALMWKSILEAQGRREDRAANNIRHLLDLIFQFPRMNPSASEPSELDIPKLFRQIRSRYKVLCATLGAKPTLRAGGSSSPTGDVDDLGGTQESRSADGKNQVWQIDKPARDEGLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQB1</accession>
    <name>A0A2R6NQB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferritin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQB1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQB1"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015307088" description="Ferritin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15269" checksum="96E67275DE3AB581" modified="2018-06-20" version="1">MFTFSLLLAAFATQCAFAAPNLVKRCTPSNSTSTPSSTNVTAVTGTLYYYVNAFYASCSQLQLPDTQVLQFALNLEYLESTFYSRGLSQFNETDFENAGFDSSVRERFVQISEHEATHVKLLQSVLGSDAPEPCNYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQH1</accession>
    <name>A0A2R6NQH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQH1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQH1"/>
    <dbReference type="OrthoDB" id="3266718at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="208" mass="23291" checksum="1ECE6F9DB593D2B8" modified="2018-06-20" version="1">MDDYPHESSTLHSLTRKRKADSDDCQLSNTPSNNTADSVLLDTAATPRMPCKPQNGHHLLPSWQQQQLMSTSVSIIPTFCQEGPSRPKRPRIEIPYAVPAASRRLRRGRISHSPMASPTRRFVRRARLVDIRDTGIVSAVEPRRVPPLRTGNLPPPSPSPHTRISHSVPVTPIEPISPHIPSHQPPINRETLKELDLEAILRNPQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQJ1</accession>
    <name>A0A2R6NQJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQJ1"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="53038" checksum="D164D9E54C2BCC0B" modified="2018-06-20" version="1">MVDATPLNIRSPFRHRKVSKRDGSQKFVVAHHMVGNTYPYTQDDWTSDIQAAHAAGIDGFALNIGSDDWQPTQVASAYQAAAASGTDFKLFISFDMSVLPCSSPDDAAALRNYITTYAQHPNQLQVNNRAFASTFAGESCSFGQGSVPQGWSSQFTQHPDLSGANAVHFVPSFFVDPATFGQYNGAMHGAFNFNSGWPIQLTANTGNSVLGPLGTNLASSASQAIGTITQALSQFVGATDTDTQYVNGLKSVTTDDGAPTYMGAVSPWFFTHYGADSYNKNFIYYADSHLYPTRWESIIDNRDMFDMVEIVTWNDFGESHYIGPIHGAQPNSQDWVDGFDHTAWLDMTSYYATAYKTGSYPQITEDKLYMWARPHTKDANAPDPVGKPDNYELDQDVLWAVVFATANSTVTLYTSDSTSQTFNVNAGVNKISTDLTPGGYMRGTIVRNGQTIVDFRPDGYNFTANPQAYNYNAFAAVSPSSAPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQJ8</accession>
    <name>A0A2R6NQJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQJ8"/>
    <dbReference type="OrthoDB" id="3235960at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="65"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="677" mass="76724" checksum="784B1217DDD87835" modified="2018-06-20" version="1">MEHTIQNENQPVFLTANPGPESPETGRQAKGLISGFPSTGVTEKPSCGCCTGSHSKESTEEPDGWKVLLEAMEQADQKTLDRWKAEMDSLLIFAGLLSAVVTAFTVESYQWLTDDPASTSVILLAQISEKMNSFSVGHSFINTTLSNPPSPNISGFSVPSDAVMINILWILSLTFSLIAAFFSLAVQQWLRHIPLPEDMTIRQSIRLRQFRQSGLAHWRVPMIVSFLPILVQVAVILFLIGLLYLLRPLNREIGLAFTMVAGSLLASFTITAFLPFYYRDCPYKSSVFPTILYIIQPIAKCILYFVLFGVYIVATSIIFTIYLGACAMVMALWVPIATFVVLLSVVSILCLAIAVSFDYIGVCLRTIFSPITRRWRTVPHKLQGEFKPPISPIRHYLRSLPTLILSLSIQYFSALARHVFTSGGTQNEDGSEPWWSRVIKLLERLYEARKDKQEMVNNKFGDPDKLWLNLELKRIMLDSHLLDKLDESALASAPLTVARSDSSFIIVQKCLKDLEPTRHRALCAFKWASHHLGVVSFENEMCKYSRYSRINPSLLEKVDETFAGRFREILWEALPTDWSKWDVREDRNSLLGMLILLMETNAKFRHDDPDYPKFVKDYIDLLMKIIQAQDDLSLVLTNARRYASGYVPTALFYEGCVRYKYIFKDEGRLFVLAPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR16</accession>
    <name>A0A2R6NR16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v9376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR16"/>
    <dbReference type="STRING" id="98765.A0A2R6NR16"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR75046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="226" mass="24644" checksum="A8CA437EC4C995AF" modified="2018-06-20" version="1">MSSTSRTPYIIGCTIGAVVAGFIGYAVWFDHRRRNDAEFRREIRKDRKRAKKIVPPTPPSAAGGIDADALKEALAKISGEVVPQSSDDKEAYFMTQVGLGEQLCAQGPMFALPAALHFYRALRVYPSPVELIMIYEKTVPEPVFKVGSLSTYDPYGQSLNFVHQIIMDLTNLDVSSSTPSFGLESSESHEIALEEDETSPERGGPPSEASSQDWDKLTDPGSVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRG5</accession>
    <name>A0A2R6NRG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000910">
        <property type="protein sequence ID" value="PSR75272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRG5"/>
    <dbReference type="STRING" id="98765.A0A2R6NRG5"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="30210" checksum="A48D8444FD85FC92" modified="2018-06-20" version="1">MAETESPAQPHEVDEDEDADIIHRYNPSALDVTERFWRDLQPWLEECGYLLRPRYRPGWIPSWIGTNKRWFDCEDAFTRETRVLDATRISDGAIVSLKRVGKDGDTESKEVDIAQLFSSEALAKDKRNHCAPVYDVLKVPGKTILAMPLLREHDNPRQHTIWEAVEFFRQIFQGLSFMHEQHVAHRDCKSDNITMDPKPLYPVMYHPAEDDIKSDFSGRAKRFTRTSHPVKYYLIDFELSRMYDPNGPPPLETKFIAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS48</accession>
    <name>A0A2R6NS48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="5">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS48"/>
    <dbReference type="STRING" id="98765.A0A2R6NS48"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR75651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="310" mass="32872" checksum="07EFEEFB566C6904" modified="2018-06-20" version="1">MTSPSPYASTLDVLAGLLPPHLLQPRVGIVCGSGLSTLASSLRDVHEVPYSALDGFGKSTVEGHKSALAFGLIGPGEGIPVVAMLGRFHPYEGHKLSTVVYPIRILAKLGVRDLIITNASGGLNPNLAVGTIVVIQDHLALPNLTGPLNPLLGPQTSPDHPRFVPLSDAYSTKLRRLAFLAAHDLSFDDDALAEGVYAWVSGPTYETPAEGRFLRAAGADVVGMSTVPEVVVAKEEGMEVMVLSLVTNPVVIPDTYRSIKEEVKAELAGKPVELPVMPVVSHDDVLAVGRQKAEAMKQLVARIIEMIPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSF6</accession>
    <name>A0A2R6NSF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000876">
        <property type="protein sequence ID" value="PSR75808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSF6"/>
    <dbReference type="STRING" id="98765.A0A2R6NSF6"/>
    <dbReference type="OrthoDB" id="3269001at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1184" mass="134403" checksum="0C9E3B7593C73CF4" modified="2018-06-20" version="1">MFVQGSSRDLVTTSFLEGDDSGSEGYRTTLRRRRAEERRKALEAEDLDEHGQPISQLKHKTSSRQNTVPPLITDMVLSAPNGLPFPRTQAGSPPPLIKLEVMRDFQHIQYTIVQRAATFQVPSHLIFMRNPDTSGPFVHREAGDICVANSGLHALRTTSQENQDVLDYENFLVTTIVELERLPIANHDPIALERTQALSSAVLEISRLEAIKEFEWNKQRAMLSVGTYSDTHCHTSDGPKPTVDTGNHFVHTFYSWEPAILAPHIAVLVMSLLFNIPRRASRVLISGLRDTMRLTASMAVQRGAILDVEALLRKIPRDPRTIISRFRIDPVTRSYVCCPSCFALYIDKPLPAICTHQATPSSNMCNTKLWRRREIRGRSYDVPVRTYLHQEMMAWLGRLLSRPGLEEKMDIAYLGSSSSDGAMHDIWDAPALHTIVDPVSKEREFIIPPPQTNPSLSPEARYVFTLALDGFNPFQNKEAKQTVTTTAIYMSCLNLPPHLRFLPENLYLVGIIPGPHKPSLEEINHALKPLVDELVVFYDSGVLYTRTAKYARGRHVRGALGPLVADLPAARQTAGFASISAKLFCSCCYLELDDIENIDQATWRKRSGEKHKKHANMWKAAQTQKDRDKIFKKYGVRWSELHRLSYWNPVYFTVVDSMHNHYLGLLKDHCRTIWGMNVKLEDNDNAFAGQGSTIRVVPEPSESAMADGWRRLQERDNLFECSKAVLWHLCTRLSLRRPKLNKKYLVKELLAWRSKQSHEAVSKEVAAATAASRPTKEAIRHAVLGQSTLASIQADMARTILPSWINPAPKDIGSKQRGKLSADQWRTACTIHFPITLIRLWGGEADKQDMLHNFLSLVSAVEVAGMLVISKEHIKVHQKAIHSYVKTLKALHKEAVIKPNHHLAFHIASDFLPNFGPLHPIRAFHTERHNFMLQTINTNMKFANVQALLQDNQVREATAELIATYEDVHYEDRRGTRIREAFIQNNRDVEITGRNNNILSPDILGRLVRFLNCEAGEETYVNIRDGIRSPGHVQVTDDMSICSHVALRGVSYKSDGMSPRDSNIIFRRSSDLPSEAGRIKMMFRHSRSHGKSHIEEIFLVVERLVELTRNDVKYDPYRRFDWVGGRLCYDRSDPDVMIIRPRHIVSHFARTSMTVPGISTGCIHILPLDRMLHFSEQLENEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSZ4</accession>
    <name>A0A2R6NSZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">18S rRNA (Guanine-N(7))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v8702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSZ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NSZ4"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="168"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR76040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27832" checksum="A29558CFED6DDF9A" modified="2018-06-20" version="1">MTYRALELLNLPPDEPAFLLDIGCGSGLSGEILDEEGYNWIGVDVAPSMLEVALEREVEGDLFLQDIGQGFGFRPGSFDGAISISVIQWLLNAETSHPTSSPPHRLTRFFTTLHSALRNPSRAILQFYPTSDDQIQLITSIAQKAGFGGGVVVDYPNSKKAKKVFLCLFVGSGGQQIPKGLDGEDTEVQEGRAAFEKRREKSGKKDKNGKRRGIKDKDWILKKKELYRQRGKESVPRDSKYTARKRKPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTB4</accession>
    <name>A0A2R6NTB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v8605</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTB4"/>
    <dbReference type="STRING" id="98765.A0A2R6NTB4"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="451"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="915"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="919"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR76182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1123" mass="124643" checksum="B401A2A0A4BC8FF9" modified="2018-06-20" version="1">MAQDCSRKREQTCKSPISTPSSTQSVNVQQSNVLRPQNETIATNTATGRSPSTLLPSPSTSDTPVAPPPGSTLTTSLPSIATHFGNYTVHKTELPTEQICRQFMRGKCSQGKQCKLDHPPRHEWHRYLPKIDKPCIGYQRGQCFLGENCQYRHPAEPSDMVPSESIPLKTRPVSSSSEKENAEKLSSPKQKKKRCTVPSNPKEGLGTSSSTNVLQTTQNDSSTLNRKKVQPGNQETSTKAKPIISSSDKGPSIDVSTRLLQKDQNTKQRRRYPVKNVRDSSSDGTVNQTSSIPMSSSSNLAGEATTSSSNFDQVSTKSDECRDFRHGRCTRVSCKYRHVATSATVENHVDRLVGLLNKSVEPEKPKVQPWPTDHPKFQTPAVQSALEGRPLPKPIPLLPPGLGLEVGSDAPASKSGSDLPESFSVSVLDSVQVTFGPGFEIRDLQTGFESRKVFIRNIPANIDLSTVKEILVPFGDIRDIQFLEQGGKVCTKTVRATFGKYTQAAEAVSALNGAHIFEANISVQLASYKSTSLGKGTVHDGDVYLEFPAPCRTGFAGYPTTALAQQAISRAHGTELRGSWISAAIYNGIPRLSAVNVKFYGLPPDAQAKDIRLFGENEGFMFKDANYTSLQSALHKLQHVLERSGELISLNIIAPPYIRQTVRAWAHFTSPIAAARACRELNTCRQYFVGNNRVYAHHVWSVSYTLPAEVFDAISEDIHRLRSCVCASDNRCNLIISDRRRYIPSTPTVSVKVLADHLPMLTRLKTSFESILRGERVVQDGSTVWDPFFDRPAGIAFLNGLQKSHGLLVNRDPRRRTLALFGPPRRRANARKVILEKVAQLHAQRFHKFPLDGRLIGLFVSADLMKLQEELGRENVVLDFAGRTLKVRGNDDARQVVEIILRRAKQRYMPEKKRPQHECPICFCEASLPVTLDCGHSWCKVCLTNYLLASVDTKVFPLTCLGNEARCSHPVPLSITRDILDPRDFTSVSRASFLAYIQSKPSEFHYCPTPDCEQVYRSAPPDTVLQCPSCLVRICGNCHVEFHEGSRCPTRESDDERLFEQWTQSHDVKNCPGCKVPIERAEGCNHVTCIRCKTHICWVCLSTFTKGEDVYDHMRNVHGGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTG5</accession>
    <name>A0A2R6NTG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v8857</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTG5"/>
    <dbReference type="STRING" id="98765.A0A2R6NTG5"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="14">
        <location>
            <begin position="42"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="305"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR75943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="486" mass="54800" checksum="C3CC4FB86E2625EE" modified="2018-06-20" version="1">MGSKNHEVVPTVLIVQISGLRNGGVNKLLGSLAKRNLVAKVQNSKYDGYRLTYGGLDYLAMRALSKRDSMYSVGNQIGVGKESDIYIVANEEGDEMVLKLHRLGRISFRAIKEKRDYMGKRKSASWMYMSRLAAQKEWAFMKILHEHDFPVPRPIDQARHTILMEFIDAYPLRQVSELPSPGALYSTLMDIIVRFAHAGLIHGDFNEFNILIRRESGQPIVIDFPQMVSTSHLNAEYYFNRDVECIRTFFRRRFNYESKLYPRFKSTMKDGAAEEGDGFRLDVVVAASGFKKGDQKVLEEYMETVTKETDNVDGEGDSEEEEESGEESEGEAESEKEEEDMTVESHTQADKGKGRSDVEDAHQTSSDHLAPVTNPSPTRSTPDAESDREEDSTGLSPISLSRPLSRSPPASRSQSPSSIIGRTAALTLSHERDITERIVTEVSKQRAREQRKYHSKKGAQRMGGRQKGSKAKMDTRVKPDRSGTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTL9</accession>
    <name>A0A2R6NTL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="1">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v8466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000846">
        <property type="protein sequence ID" value="PSR76431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTL9"/>
    <dbReference type="STRING" id="98765.A0A2R6NTL9"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR76431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="22769" checksum="DF0FF2BB57F7FA2B" modified="2018-06-20" version="1">MSTNLDKALEIIKVAIDEDTKQNYAEAYKQYNNALDYFMLALKWEKNEKMKQLLRKKVDEYLGRAEGLKEVLNAESDKKAKKAVGMSNGGVGKGSKKADEDEGDPEVKKLRAGLAGAIIADKPNVKWDDVAGLEAAKESLKEAVILPIKFPHLFTGKRTPWRGILLYGPPGTGKSYLAKAVATEAKGTFFSVSSSDLVSKWQGDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTZ6</accession>
    <name>A0A2R6NTZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FERM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000841">
        <property type="protein sequence ID" value="PSR76542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTZ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NTZ6"/>
    <dbReference type="OrthoDB" id="3031116at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01765">
        <property type="entry name" value="FERM_F0_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="110" mass="11987" checksum="6326F8E9BB8A8F8B" modified="2018-06-20" version="1">MDDFETGSTTTLPPSSSSTTLPRKQTTPAPLPAVPAKAKLIPTNSVTLRDGTTVRVRIEATLTVEDVVRQLCLSVKVKDPPGMFALRDESDELVTNENLRKKIKAKVNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUJ3</accession>
    <name>A0A2R6NUJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000824">
        <property type="protein sequence ID" value="PSR76935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUJ3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6943" checksum="F1C9853530B13C3A" modified="2018-06-20" version="1">MRADEGLSVKQNLAERLSNLLAERPYRRAKGMKEGLSNPRVIASGGFKHLVNRNAIHLVQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUT9</accession>
    <name>A0A2R6NUT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000812">
        <property type="protein sequence ID" value="PSR77145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUT9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="154" mass="16663" checksum="47F5C330C8BC7DFF" modified="2018-06-20" version="1">MSAGSDYVVGNPAWREILADVPVANFAGVDTHYTLQWFSGMVILGGANARLAATFGANTIATANTAGNLKPEDTKTEDGYLILGTGDPNGRCVRFESTRHTDSLAKFLSSVRCAPCLRRSTLFGRHKVIVTPHLTGWTTAYWDHGKINNPYSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVE0</accession>
    <name>A0A2R6NVE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVE0"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRA" evidence="2">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="307" mass="33816" checksum="2650B1D0A85491DE" modified="2018-06-20" version="1">MATEGRAVRDPLAETLDKLLRPAELRKQIRIHILSGRVDEAIELLHIHFPTVLPQDSNPHQHETEIPLPSDPPSSSESFTFTSSTSVDPTHLLLNLRILGFSEAARTVPLSYHPPGEPLPASPASPAISETKKDTGDPELSEQQLILLHKAQKLYSEANCLPKPADRATYLKELAQVSALLAYPNPENSIMAPFLAQDRREAVADQVERAILHCRGESLVSHLEILARYNTVIWGNLHDHNIRVPPPTKWPPGVQLPPSALSLRSWVGTKIQESSAGDKTPSGKKPSEKESERAPTFSLTEFLNAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVI1</accession>
    <name>A0A2R6NVI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVI1"/>
    <dbReference type="STRING" id="98765.A0A2R6NVI1"/>
    <dbReference type="OrthoDB" id="2505887at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="860" mass="95467" checksum="A357EC6921DDF8C3" modified="2018-06-20" version="1">MSSVDLDVQERPARRAAAKKASLQAAEQLKSSPIRATSAHVDLNFGEPSRPRMNVKVTYGKKSRSPAKNSPNRPPQISKNLSAPSLRSLPNSTARPRPRKAPTQAHKELQVLEEASSNDGSLTSLSEDFDDDLIEAAPVSPLLVPQKTAHVVKAHAPRQKRRLSPLDSNISSRSNTESILTPLSSPEPEEVAKKDNGSHASARERMGQNNGPRPSASSRRRPLKLSYSAPSIPTSSVVTITNVAEGHFGGEDCEFAFVRLDISGEVSEKEESMWWPAKVTSSKPLRVRLFGRSPGNSITQTVSEITVLSPSPQVFVSCVSASGRLRFDEKSYSSGRRFSTLNMSPRKRQKTEQSDLDARWCEARDLLLEAYEEDNDGLPLLVSHYKSKDRPAGVRPRAVGVVIQGGSVSEPEETQAPWEPPGPNELYDLPGELVLAKEKPRSSEYWPAKLIEYIPPQKPTQKPRYKALFFDGIIKDIPKDMFYSIYDTEFKSCKMGAAADDYDLNEDAEDEGADDFTMTFDDNVDEESLRAPSPDLKEPAPIAFAHDLTIPEQFEYAKPVLVALMNGEYPPATRLHVAFMKGGRWRNQVTSSAWKRGELSHKEKEELSDCIRRWMHKRMVRQKLGLVPPDAAVRMQDGDHVSPDEKQQDTSAVGQVVLEKDDSVEPPPCTQSSAGDTEYAHSVAAGPPSSFIVSDILEETDGEVEILDSVDSIDKNVTKVVVTQPAANAAPVQMAVTNIPEHPPELSDTDQEPLLSRSLPTYAMLSGIDQITYCTSVLLPEAILQLLLWRNNLRRSPRLLSREEEEELHRQAEERASASYWVHDIVYMKRSAEGKTLPPYVSEPPDQATSSRGRRQLRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVN5</accession>
    <name>A0A2R6NVN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVN5"/>
    <dbReference type="STRING" id="98765.A0A2R6NVN5"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="243" mass="26394" checksum="F7885EC282FA3FB1" modified="2018-06-20" version="1">MLIVNSFGLQNALERSAVDIGHFFARCYSSAVACATVMRDEMGPCGYLRYAPDSNYVQGSYAVLSLLKVKFHLDPCSFHPLIIRQLLRPEFKTFLDHESKIITLVNDVASVLEQAAAGPLHTPALYSCFLRALVSAKTEYPSSNSSISHMSNAPNGAVDTSHESSTSHSASMNNSYPFIANDPLSEFQFDGEMGPVADMSTFPPTMAPHPSEDHLGMLTMDSILSASFWDSVLVPGQSESASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWB7</accession>
    <name>A0A2R6NWB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carboxypeptidase C</fullName>
            <ecNumber evidence="2">3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWB7"/>
    <dbReference type="STRING" id="98765.A0A2R6NWB7"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015330370" description="carboxypeptidase C" evidence="7">
        <location>
            <begin position="24"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR78200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="391" mass="44420" checksum="BC427DE41302BDEC" modified="2018-06-20" version="1">MTFTTMMKSLLVVAFCITCNVRGNVQKSFPSGGSAFEPYDADLFWPLEDLGLLSSTEFTTLNHPTFAKHGVRIKKSDFCDGTVRAFTGYIDIEARHLFFYFFESRNDPDTDDVIFWTNGGPGCSSSTGLFMELGPCRVTTRDNTTFNPYSWNEKANIFFIDQPIGTGFSYADYGEYVSTTEEAAKDIGAFVAIFFEHFSAFKGRSFHMAGESYGLPRCVKWLKEGCFDTDDKINCLAAYEFCSQTIVIPFAKLGYNPYDLEKIWYVRDQLFRIVCMLIMSLPFSDDPDFVCYPISKNISAYLDHPELRRQIGVDSSFTANFSHCNYDILQRFASNADSFFPTKSYIAALLERGVRALIYVGANDWICNWAPYDKPAESLELVKRWLAGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWG1</accession>
    <name>A0A2R6NWG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWG1"/>
    <dbReference type="STRING" id="98765.A0A2R6NWG1"/>
    <dbReference type="OrthoDB" id="3357985at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="345" mass="38378" checksum="A49FA0FB5C5B21C4" modified="2018-06-20" version="1">MSSTGDNVDVFTKPEADVIVRSSDEIEFRVHKSVLSTASCIFADTFGVPQPESFKVIDDELDDAGGKDDLPIVALTEDAETLRVILRTLYADGISTIEDLGLLARVLAAAEKYEMAGIISTLAPFLHTPRFLESEPFRVFAIAYHFTLPETILIAAKATLLHPFPSSLPPELEYLPTPDVYHKLLLYRTRCEATLEPTLVDWMSVWIGFDESRFRHSIRAGAMDMPAWSTVDRGGCSFCVRGTYTTLNKYGVLPLWFIDHLERTRDMFKDRIEGPTVKSLKLLEKTISILPSIGSNGGCDCAEEAPLQLMQFSERLSDKLDEKLAEVSVQPTITHFGVISLADIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWU6</accession>
    <name>A0A2R6NWU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWU6"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="148"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="378" mass="40301" checksum="8EC88F27632A8795" modified="2018-06-20" version="1">MSSKRKWDQAGPNDADSPSKAQKVEEGKTASEAAAAAAAIAAKIAAQFAGSGGSGVQLGVKDPHDGDFIHDIDINDIHDETGASVSTKGTWYPDRSKATDKDPPLYLHISATTNEILQRAIDKVNELISMDMGSLVEDKKDRLREKRKWPEEKIPVGLDTIRNFNVRAKVVGPSGMFVKYIQQETGTRVQIKGIGSGFVDQETGQEHDEPMYIHVTGPDEGQVARAKVLTEDLLDVVRQEHAKVKTVVAAQQMELHQAQVQYAAYSAYAGYAPPQPGSAPPPPPPGEQPPPPPPDGSAPPGAAGQGSMGAAPAASDTDAYAAYWAAYGYDVNSPEFKAWQAQQQQQYAQYYAQQGYVADAGAVAPPPNDAAPPPPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX89</accession>
    <name>A0A2R6NX89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX89"/>
    <dbReference type="STRING" id="98765.A0A2R6NX89"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE MBLAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="262" mass="28983" checksum="66C5405B9F593AF5" modified="2018-06-20" version="1">MEDDSVEKASTHRQPGPCTKKAAFKATRLTPTVFLVNEHSDIYDERPFIYVKTISSANTLLILDTGCGGATDKPDIKITSLREFLETCDVEDNEGKPLNVGGKMQYVIVLTDYSTPTPNYSTSLGVVVHHTPGHTPDELALWDESERMLYVGDTVYEWEHIIFPKEGSIVQWLQSMDALIELVGTSEANICCGHVTAGRPAKDVLTAAKAFVMDVLSEKESVRSRFEKRGEVSVEYVQAGSRFSLICPERLVVVARQKVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXJ8</accession>
    <name>A0A2R6NXJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GHMP kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000703">
        <property type="protein sequence ID" value="PSR79300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXJ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NXJ8"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="6">
        <location>
            <begin position="272"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR79300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="377" mass="40468" checksum="37816E598CDB76C7" modified="2018-06-20" version="1">MVVASTLAFLAVNDKLDKDGQGTRKGELVEMAVENEKRVGVNSGGMDQAASVISLPTSALYISFFPVLHAESILLPITRTVPRAVFVCANSLVVSDKVVGAKTRYNLRVVEVLVAARILARLLSLSFISGAPASKPTLREILGAYINARIRIPGSEVLETNEVRGQASPALSVEQLEEGLGRLLGECEVLRASKLVGRVGGEEGLTMEEMVEASGLSKEVFEEVYLSWVDVEATHFQLYKRAKHVFSEALRVLQFRKLCLSVSGSSEEGDLPESTLKDLGALMDASQESCSELFECSCPELNRLTTIAREAGAYGSRLTGAGWGGCTVSLVAENDVEGFISRVKAAYPPYRDLEGERLSEVIFATKPSGGAFGTAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYH7</accession>
    <name>A0A2R6NYH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v6777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000658">
        <property type="protein sequence ID" value="PSR80305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYH7"/>
    <dbReference type="STRING" id="98765.A0A2R6NYH7"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015214205" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="22"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="289"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR80305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="447" mass="48370" checksum="0F327195EBAB6C3E" modified="2018-06-20" version="1">MFSRWTLVTLLGLALSGAAKSSTGDSVLVVLDSISDKDNFSQFFNGLTDKGYDLTFRSPKDAKPTIIEDDVAQFSHVVLFSPDSKNYAQDITPQSLVTLLEKGSNLLVALPSKKQTIITSLAPEFSLILPPPGTPLVSHFPERDTPVTVVPVTPPSSNPILTPNTPPVWFSGVPFAYGNNPLLVPILNAPAESFAADSGSDSGADAVVEAADKGGEGLWAGSQMGLVAGFQALGGARATWVGGVELFSDEYAQKELPQGVKPGNTQFTSDVAAWTFQESLALRIDNVTHHLVGETGPRETYTINDNVVFTAHISKYNSGKSAWEPYSGITDMQLEFTMLDPHIRTSLPPATGNPGEYSVTFRVPDRHGVFKFIIDYKRKGWTHLQSSTVVPVVPPRHDGYPRFLSAAWPYYIGAISTSIGFVLFSTLWLAGDDREANKKFAKTTKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZN5</accession>
    <name>A0A2R6NZN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proteasome activator Blm10 middle HEAT repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000632">
        <property type="protein sequence ID" value="PSR80950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZN5"/>
    <dbReference type="STRING" id="98765.A0A2R6NZN5"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="415" mass="45352" checksum="45FDCC257AB15446" modified="2018-06-20" version="1">MASFLPFSGTELYLPTVFNLWGSFNSSIVNDWFLELCGDLAEEHVTGHAGSAEWRDVGIWSEEQWTLLGRGTSALETRRLTPSIRRAFVTTLRTPVLLAMFSKDPFSSTSAQGALRTMALLEPGLVMPDLLERAYSGLEVVNETHRTTAVLSALAGAALPLVSEKVWLGGQKHIVPLLELCIPGIDLNDPMKTLCASLFVVSVVQHMKIGDLSIQQGGAPLSDAQAEEMMDINGHDHSQIPSGTDVGETVILSREEGRTLARDSAAGFADWVVSLFRRILALYENLPEEGGKKNTTGGKMEEAVLKSLKGTLDTLCLHLSDPLFDLVLQLVYDYGITNAKSNAVRAFGQLVACLARVKPEQVIAKFLPYCMSQIKELKHGASSVRTTSTHTAIPSDTTLHWSEFLVIHLYFKPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZP3</accession>
    <name>A0A2R6NZP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000618">
        <property type="protein sequence ID" value="PSR81452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZP3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="121" mass="13834" checksum="8E29039CD03EF1FC" modified="2018-06-20" version="1" fragment="single">SDPPTNAPPDDIRRQAEELATLVRGLKRKRMEYDEDVLSFQGKQKTALETFEKHEQTLKGLENALRQKDEELNGKKDILQQLKVELEEREAAIAVREEQLTLLSAFAQIENANQTLNFQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZW7</accession>
    <name>A0A2R6NZW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000607">
        <property type="protein sequence ID" value="PSR81804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZW7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="18907" checksum="F2EBD69AF5C2646A" modified="2018-06-20" version="1">MPASSSCLPAHLARPTPVASIRIQQPPTPPQSSLAAPEINDEEGVEDVEEVAENPKKQRFDKLCEALDSNPKKAKLVDKYKQLTHKAQWVPLSISPFLDTEFTIRNGAPLPEDPSMPVDDLEEISKMSPKEIKELWYCYNALKKTITTIRENEGLWEGNSLAALIGTIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0F6</accession>
    <name>A0A2R6P0F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000588">
        <property type="protein sequence ID" value="PSR82392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0F6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="15984" checksum="D4F308FCE6A3EC90" modified="2018-06-20" version="1">MSAPAHNTPAFSLNKMDWSFHNALKWALWEDMEEAGRRALTATENELTGDWNQVPVKKFFTAVANTAQNLLNMRWAQQVIFEFPCIVEFFPNRHIPSTGTIPAPAAPLAPCSSAPRVMFALLSPTAPPCTLPQPSTVANPTFCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P124</accession>
    <name>A0A2R6P124_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P124"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11427" checksum="13E4B9B9B0853CD4" modified="2018-06-20" version="1">MLDSVANRCAKGKQDDLCDCEESRAKYNVSNRPTILESAENEYQLRDDVNHGTDQGPEDVNDPKTERFGESETCKALERGDCNEETDTEYDQAGYAQELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P145</accession>
    <name>A0A2R6P145_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P145"/>
    <dbReference type="STRING" id="98765.A0A2R6P145"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="2">
        <location>
            <begin position="2"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="254" mass="26747" checksum="028F775D3AD58E9A" modified="2018-06-20" version="1">MDVTMGFVFPPVTTPPSNEFIIQLIAPITNGYTGISLGGQMANSLLFTLWPYDNELILGPRWTSGYVLPEPYPGPETTLLPSSGINSTHIKATFRCQVSTTANDPTRLIARQNCTVWDAGSMGSGDLTSFTVIAYVVATTTEPSDPADVASVIQEHDDFNFFGLDLSQVHDPNYDSYINAGSSTSAAPSSTSTVHSSSSISISSTSAAPSSTSTVHSSSSVPISSTSTASGPLQTQWGQTNVPVLVFATQNIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1P4</accession>
    <name>A0A2R6P1P4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000555">
        <property type="protein sequence ID" value="PSR83653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1P4"/>
    <dbReference type="OrthoDB" id="2803683at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="947" mass="106812" checksum="1B44B24C70F3E41D" modified="2018-06-20" version="1">MIALYIAGLKENAHLMEATNVAERLRILDEYEAYWKAARFVSQRITEPISAAHIGLWYEGGLFIRPTPDWAVQFGFHQTHKTLLCQHFTQSSSNAISPTWRIESLYDFDTFAVHPERDLVALLSLEATNIAEPSRIIKFFILGTACLDSFYTIQLYSIEDLIFRMDSTVPAPRHIATFQLPAYQPQLILEDQLTFTKTTQGSFLRERSNNPFFLLPSSSMLRIDGIWARNPNGMGHSSGHRRGITIFVHPSSFLKILSRDPNSDCYGIEFFPWETWGPEYSRCFDVTYNARQLYASYGTRIVLDNSLLDFNPSSVARELGRVRTLDESHMAEASTPQSHVGHTLISGDPVANTRVVTAPTIIERGRFFANDIETTLPYLETDITWPNKVQPDAIFANDSVWIAEYRDLLVTKQFQIIIDGTPELQYMIALYTSGCDENAHLLKSMLVPERLQLLHRYQYSWKAARLVSRKITVAISAYSISPWYRGNILIRPALTGAMQLMGNPHNTLICQCFIPSGSAGILAKSWNIEPAHAFCAFASNTEYNLVAILSSQNAQYNIHLLRLSDGTSHGEMKISSSARRTLTGLITMRFEGDILGVARYRLTGEILDLYLFNWKNCSLVANLTHRSNRYEMSMKGCFSFISSTSFILGMSCSGCFYAIQLYSMDGMMIPIDGTVPSPRHIATFQLPVFQRQCILTNDMTFSKTIHGSFARNVSTTPFFAAPSSAMLRIDRVGARRANPACWTYITIFVHLSAFSEILENQPRNPVDNPDFFPWETWGPRYTRCFDEAGSTNYSLPAEQWRLYASYGTRIVYNDSLLDFNQISVAQELNYASYQALNATESTSKSDSPLPPTTSHRMDNLHAGKMINTVDPPPSRIVTAPTIIPRGQFFENDVESALPHRETRIAWPGNVRPKSIYGGEVWIMQGPHTAIGLPTFYTLSLDSTLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1R4</accession>
    <name>A0A2R6P1R4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v5674</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000555">
        <property type="protein sequence ID" value="PSR83667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1R4"/>
    <dbReference type="STRING" id="98765.A0A2R6P1R4"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="126"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="395"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR83667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="579" mass="64586" checksum="9F12D16D0681DAB4" modified="2018-06-20" version="1">MPKTFYASQGDSEPCVVIKNGIDQHAYVLERRPNEVYVHYAGTDKRLDEWVLETNVRLLKSAAANGHSAEGSIQPIVESSSSHQNGAAHKKRKRSASAEVLDGAEGEATIKMSEEEYDIEHHKQITAKRNFDKVIFGRWQIKTWYFSPYPLTETEIDEHTASSVPGPSGAHTGSLSTARIPGVARASFKSHGRTSDLLAGGLGRTHGAGEKSVLWVCDKCFKYMSEGLSWELHVKKCTRKHPPGKKVYQRGAHIVWEVDGAKEKLYCQNLSLFGKLFIDVKTLFFDCDNFLFYILTDADSQRDHVLGFFSKEKLSYDDYNLACIVVLPPYQKKGYGMLLIEFSYELSRRAGKLGTPERPLSDLGLRSYLTYWIATLVRYFRRLLSVLPPGSGKIITNGNSHTPDTDLSMSPTRESEEANGLPRKRRKSTKGWDGEAIEPMMRNAYIAEDDGARGNTLCLTMGAETNCLGPMYTTFRSIEMKANPDGSATSHVVVRCTLADLARATGLRVEDAAFALNECGMLTRRKQIDLADTKDREKDTAVGEAEAEECIVISREMVEAVARERGVKKMCMDLAHVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1S1</accession>
    <name>A0A2R6P1S1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000555">
        <property type="protein sequence ID" value="PSR83664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1S1"/>
    <dbReference type="STRING" id="98765.A0A2R6P1S1"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="270"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR83664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="421" mass="45215" checksum="AB632EF27EFD2AF4" modified="2018-06-20" version="1">MVDAATESSQAESEGPEGSDKPPHRGPSANKLSSHQDKPSKNGTQQTHTSPSTTAPTASVSATRPYTESPSNSIPLPPPEFHSFPKAPGRTRTDLQHLELGNMASNGVTRMKQQASSSTSGSITPPTSESPSPSECESWSVPSTQPPSRAGSFSTGKSGGKLEPMTAVVPPKTPSKNGKDSSKTPTATKVTPTLSKDSTASRSKGSGSRPPSVHSDGGGQKFTLKDLLGTPKLARRSSARSTSSKKSDSDRGGKSVAGESTTSLLKKYGVCEKVAIGKGATSVVRLAHKWDRSEEKLYAVKEFRKRRKNETEKEYVKKLTAEFCISSTLHHTNIVETVDLVQDENMHWCEVMEFCPGGDLYAAIKRGGMSPSEVECCFKQILTGVHYLHSQGVAHRDIKPENLFFDTKGHLKVRHTAETIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2C3</accession>
    <name>A0A2R6P2C3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2C3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="167" mass="17206" checksum="DDA587EA9F61BE9C" modified="2018-06-20" version="1">MVQSRRNVCTYEVPSAGTVGICALVAGELVDEYTSVTVIVARAAAATSLTASMTGRTVGLEDILESTGTSTVGVRTLVPRVDVDEHSAVTVQIAGAFAVTATSVAGESDGLARKAAGVNRRSPKEFMSGGAGGVCTSFREDNESGGRDEDGETGKHVERLDLKKGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2C8</accession>
    <name>A0A2R6P2C8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2C8"/>
    <dbReference type="STRING" id="98765.A0A2R6P2C8"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR84238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="689" mass="78114" checksum="E538D714E6EF8DDC" modified="2018-06-20" version="1" fragment="single">LAGFNANDGEPSDNAAVWSSMQLCIDNRAEDAFDVAYDPNDRESLRESEGGSTKPLGQMIHYVREQMSHQHRVFMFSLHTVHDSARLIRWDRMGAIVTEAFNFVLQPQILAEFLFRFSLLGPEGRGLDSSVELAGPQECHEFTEAVANYLDSFGERKPPHFDSTLDASYPTCKIHIDESCSGERSSFIVRRPFSEIPFPCGRATRGYIAWDVGRKKLVFLKDAWRPEESSRLSEKEAYETLAEHKVPYVPAVLIAEDVHSSTGEPQRTVTQDYSDIPFGSRCAHLRPHIHHRIVQELALPLVMMRRSKQLVQAIRNTLVAIQAAYQDAKILHRDISMGNIMLDSNLNGILNDWDRAIRLSASEEHHAARTGTWRFLSIEQLRSETKAHEIHDDLESCFWVFLYAALHHFRHQPVPFDMSIFEDVWDRKDKDGTMHYFGGGRKRATLALGHVIDLKFDCAPLTEAIHYVSSIFEKFHGSAVGSRLPGDTGLRARAARAKVHAEMEDPYPLIKFLDTVLDREDWPQEDDAVFDPYPPPKVQSPRKEEEDSYSGQNSMYIDSNHSPSPTAHSDKGREACDSQPLISEDRLGYTRHNAMSSQPQPTTPQATDVAEHPFSLALTSEQMNGEPPRTYEANRIGKRLAPGSADYATDEPKAKRPKMARRNPKQKDTTRTHAMTLRPRAKTSTYAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2H7</accession>
    <name>A0A2R6P2H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000534">
        <property type="protein sequence ID" value="PSR84412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2H7"/>
    <dbReference type="STRING" id="98765.A0A2R6P2H7"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR84412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="141" mass="16699" checksum="68D98053267DD469" modified="2018-06-20" version="1">MDTTNDASSVKKLRVMLPQELIPIHPEYDVQDWDSAEGAIDWSRMVNALRKVKETGVIPPEHYSHDHLNEQKEVPVEEAQLDRWREVFTRLQREREEAGEKVVWVIVDGFLLYWNKVRVCLSVFRDRVLKGRRRSAEWESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5E1</accession>
    <name>A0A2R6P5E1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000532">
        <property type="protein sequence ID" value="PSR85531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5E1"/>
    <dbReference type="STRING" id="98765.A0A2R6P5E1"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF453">
        <property type="entry name" value="S1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR85531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="309" mass="33734" checksum="3A17C6DA196B1333" modified="2018-06-20" version="1" fragment="single">IYIDQPIGTGLSHGVVDVNSTFAAAPPFWTAFQVLLESREFHKFESREFILATESYGGHYGPEFVTFFDEQNAQIEKGAIQGEKITVSALMINNGWYDPLLQNEAYVQFATNAPGYGQLQSDEVIAALNQAFFGPGGCQEQEMACFAAEEDADSNSICGTADDFCIENVFVPAVGNRDSDDLRQNSSALFPPEFYVNLLRNSTIMQLIGVDPGVTYRECAGSVDDQFSRTGDDARTLLPQLASLVNSGLKTLIWAGDADINCNWLGGHASVLAMDWFGNETLHNTPFTNMTIRGDAVAAIQNVDNFSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5K2</accession>
    <name>A0A2R6P5K2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5K2"/>
    <dbReference type="STRING" id="98765.A0A2R6P5K2"/>
    <dbReference type="OrthoDB" id="3357813at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR85867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="648" mass="69804" checksum="DE6B5F389C28A356" modified="2018-06-20" version="1">MPTEPPPTYSQDQTDLDLPPSPNLEPQILILPSENGVNFQKGYLGADGERAAIEGELQVKGAGTGRWAHVMMSLRTIEHTHNSEVELASSEVVLYSALSSQSEGGPSPSIYPFSIPLPPDTPQCVHTSQSGLEHTLTATLQPADTDAPKLSSTILVHTRRYMSHPHTLHTEPETKIMEDPTRVEVQIPRTAFTAGEALPLYITVPSPRRELILDEGLRLRNIRAELIRIVKVNGSTDESGLQSTINSTKTGAVEASTSSSSHSLDMRSILGVPGGGEVIAVSGASCRLHPTRPLQIRLVLRPPHEQASPISHSGHDHLPATELGQAEPTTSCASISQTTLLHSISFAVCVHITFMHMHSHTERISAISIPVTMLPPSAPLPELEESMDTAYHKKHDRPPARTVRQDDVDVPDYSESEAGPSYAPPPFEEREAPPPFFLAEPEASTSRLPTFLESEAEIYVQADEDPANVPPPQQLFFQGEGVDFGFTPLEQFDGYPDHDGSLTPPPTMEMATRDPNVTNLATLDDNAALDALELALENHPDAAHDDALPPPPPALDDPSDPPPSIDSDFRCPGARQISTPPQHHAAPAFSPHTASTDAVVDAAQVASHGHAPPPYAGVPDHNSDEDHEHVARPPPYVDLVPAAVLDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8U4</accession>
    <name>A0A2R6P8U4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHLCEN_2v5223</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="MLYV02000516">
        <property type="protein sequence ID" value="PSR87216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8U4"/>
    <dbReference type="STRING" id="98765.A0A2R6P8U4"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="17">
        <location>
            <begin position="119"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="19">
        <location>
            <begin position="413"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="18">
        <location>
            <begin position="730"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PSR87216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="974" mass="106314" checksum="0AA3B6F2A992D1D5" modified="2018-06-20" version="1">MELKSWLSAPFKFAPIPVSVLAVLLYGVVFASVLVTDQTPAVAKDLGGLNLNQAYDDLHRITSRPHPYTSHANDDVRNYLLSRLRPIVASQDYIHLSNDLTSNATYHTGKSAIYFEGTNILVKIDGTDASVVKSDGVLFSAHYDSVSTAPGATDDGMAVVTLLQMVEYLSKPIKRPRRTAVFFFNNGEEDGLNGAHVFFEHPWSNLTTSFINLEGAAAGGRPMLFRSTSLSAARSLRGPGVMHPHGTVLSADAFARGVIRSGTDYSIYAQGMKEQKDGLSGVDIAFYKNRAFYHTPLDSIPGMGKNEGRRSLWAMMETTKGAGLAMLNEDEGVGSGDTGVYFDVLGRIMVAFSLRTLFVLNVVLLILGPLVVIGLLAWVLILSNKYARRYEEPELTQGDRLKRVLVAAMGWGRFWLALLLAIGLHISLVAGYVKLNPFIFHSKPYLVLTTILALSFLSISVPLSLLNKLWPSPPSSQKFAIVLELYFISWVFLVFATVAVNNIGIGGLYFVTAWNLCTWAAAVSAVAEAAVRAGRGGEEGGKGEFDLVGEQEVNGADPGDHRYVRGVMYQAPPEEEDGDSHQESEPVETDPTEITPLMHQQRRRSTGGGEYVVGIDNEAVPVSGLKKRGSGYVEFGWWIAQMVALVPLPAVLLFQIVLLLVHSLNNTLVDGSSPVTAYGGAAALSLLIFLNLAPFSHKIHHVLNILVLVVFVICLIVAWTAFPFTQEAPLKLFFQQSVELDAAGFLLGTSHNHARTFLTGPQGYVDKMIVPDLPSSWGKDIRCQTDETLRKGLLSCAWESGLWPSPGGNASASLAPETLMSSAPATSLSDWMEVTAERVNASSGRISIKGTNTRGCRLYFNKPIKYFHVREAGRLQPGYELPDTGVMDVMLWSRNWENQFVVDFGWGVADPDVKMEGRAACIWAEYASSTAGSPHSAVSAQIPALEEVIHFLPLWATVTKWTYGLVEAWTQFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P922</accession>
    <name>A0A2R6P922_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000521">
        <property type="protein sequence ID" value="PSR86945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P922"/>
    <dbReference type="STRING" id="98765.A0A2R6P922"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="231"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR86945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="474" mass="52294" checksum="32CD71557E56171D" modified="2018-06-20" version="1">MSPPTLSTARSPFDNAKADTILQTSDNVQFHVRSAILSEASLVFCGMFSLPEPTNPPETPVITVTEDSRTMDALLRLCYPVCDPVFTDLSLLEYVWEAARKYGFDYAAEKAGRAVKTFLGTSPLRVFAISCRLGVEDVAGLAAIAWKNSDTFKSLSSLQTPRKFEGTLAGGSYVTEMKNISSEAYYRLLSFLRTNPNPQNPRFCGTSVSLTVRQNSQRVHPTFDVPSRADADCVIRASDGAEFFVHKLMIRSASAEALLAGEGSLDLRVDDLPIVEVEIQSDILVELLKLCYPTNTLSVDDCAKIRRMLQAASSYKMARIVDIIRKRVMDLLDMHPLPLFFIAIEQSWEDVAEAAAKRIATGAIKDLYTPEMKDVSAAAHFCLLKYCHQYSVIVSDAVSRYSTDAKLWKQLEFALDSALLISDSIVHVPLPIVESSLSSRNGSSIHEVVAKSEAMASRMKRDMSQVNVQDTASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCT0</accession>
    <name>A0A2R6PCT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCT0"/>
    <dbReference type="STRING" id="98765.A0A2R6PCT0"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme synthase central" evidence="10">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="9">
        <location>
            <begin position="213"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR88863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="341" mass="36766" checksum="161A5012224D3AE9" modified="2018-06-20" version="1">MPVEMRKATADPPRPSGTLSVGGGLEQPRGYPGLSISSFSPVTNSQLYSTLCMASNISALSGGSLLLAWQLKDKHVLIVGGGDVASGRIESVLVADAKITLISPRAGLHSLTKRFIEATDRITYHDRVFNGAEDLGGIDMVLTAIDDVEKSREICALCRSLKIPVNVADIPSSCDFYFGSQVRDGPLQIMVSTNGQSPKLANIIRRKIEESLPEHAGEGIEKVGILRSKLKERAPGVGGEVGKRRMRWMIDVCNSWEMEELALLDDEMMVKLLDDGWEKNRVPKLTEVAPHARGTAASKSDLQGQGSPLPFAMSIPLMYGVITGLVFTAGLVTGSVRSTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PFX7</accession>
    <name>A0A2R6PFX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000500">
        <property type="protein sequence ID" value="PSR90288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PFX7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="20119" checksum="F9F2638A099856A6" modified="2018-06-20" version="1">MSSTEEKPNGQDAQSEEGKTKWSLAETQVVAPQGVPDNTKLSAASPQTQLQQSDPEDLHTSITVHNEVSTPAAVCIEKPVNVAPQPEEDDSALDTVAIEENMQAAERPRGELETNVPGLVDTAQDERNSVAPPPAHDPAITAQANSDPSHGTKAQPSDCNTKAKARPKKTSKVKGTKKSTRKGAERAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG66</accession>
    <name>A0A2R6PG66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG66"/>
    <dbReference type="STRING" id="98765.A0A2R6PG66"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="240" mass="27512" checksum="587FA0092FF4660C" modified="2018-06-20" version="1">MVWAPRRTIKECDAILCGPGMPHEMESRVVDGRVLRVYKNLWPSLRSFWLWATSEFSDKTYIVYEDNRSTFEQILSRSLLAASVFKNVYHVQKGDRVAICARNIPDYLVAYWAYVERAQRVYQAVNDLFTAGVTGLILFDVLGRDSQWKGVDLWENVMQSHKHDPRRILLEDPNVQPEDNATIIFTSGTCYGSGKSGATATRERHSCRYGRTPERSSRVGSILSCYWKHQSVGRKRPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG84</accession>
    <name>A0A2R6PG84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG84"/>
    <dbReference type="STRING" id="98765.A0A2R6PG84"/>
    <dbReference type="OrthoDB" id="4743193at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="307"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="629" mass="70683" checksum="6E011DA0398F2E58" modified="2018-06-20" version="1">MNNKMLSLLNDISTLLNEHRCTLSDVILLLLNPATVHSLSGDLVSSSGRILRAFKAHPASCDDTSSFANEAVLDIYDRELTKLTSADEGWHFNASKAALEQLSQFHLEDMAQRKEKAAPQLFSLLNRLLAAAKPEGGMHGDLGEGSADLEVEDELDDLGDAEYTTLSKEADGVSAEKLRKQHEDIRRIKVIDMLARMGLTVSVRSIHRSLDSLIIEAASNIRTIGQTLTAAYCYDNFDVDLKPSVPTVEKSGNTLKHLTSSLVFPLQHGTTAEDLKCSDLLWKKSSNNPKAISTSRKPWTNLLTLHADTRIKDEHGLTARDRFNAYKFLYDLCHFGPPEFRVYQKDIKPPEILEQIPVVKTPMTPLCATRDNNSEISGNIETIRHILEQAGLGVPGWESGDRATTDTSEYVLLFHGDLGTGEKLESALEWRGADYTPASRLQNIIFVLGGFHLKMACFEGCWRVFIKPDEGRDDSTSVMSDVAVIRERETGVIASKPGYRRTVQVVQHVGIGRRLDCYRAEANKRNIAHITLEDYAASKPSFVELQDMARYLALNYVGRGDVIHDLRRKPIKERDQHFENALIVNQYFLLCEELTYAMNFGDIKRFETCFLPWIFIFKALDICGDFWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ67</accession>
    <name>A0A2R6PJ67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000480">
        <property type="protein sequence ID" value="PSR92128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ67"/>
    <dbReference type="STRING" id="98765.A0A2R6PJ67"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR92128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="406" mass="44614" checksum="15F358B4FC54D2B5" modified="2018-06-20" version="1">MGMEQINGSCTTLMSTLLKSCPGGTLALASQAGFPAPPLLDRINYPDVTYWESEDWRKHGTKGVTQLRGKVDRSTAAKCAFIQKADGAELSEEEWKTMHNMARAIFNGLSAAPESWLAHSTTEQRTTVYNELMFKFPFLSFCNGYWKAEKYVINQFPLWKNARKETIKMEEDNPRKRKADKDSNDHSVHEHGETKKVASELHGSKKVVSVPAVQTLVSNPLLGMAVPKIITTVSRRPITVTEVGTDQESQETAQNEIAGPTPSTPDTVPTATTIAMTTATTSEAAIIQAAAESAPIVLPTAEVTQANLLSTTVAHSTSKLFQPGPKPTGRNLYGRTWKDLNPNGTTAEFTKAWQNLPKVEKRVYDRDAKASAKGNVPFTKAGIGLRQRLYAIIYDNSDFPLGLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJK8</accession>
    <name>A0A2R6PJK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000477">
        <property type="protein sequence ID" value="PSR92305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJK8"/>
    <dbReference type="STRING" id="98765.A0A2R6PJK8"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR92305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="284" mass="32275" checksum="64C457C0133BDEA9" modified="2018-06-20" version="1">MPVGSPSNRRNGKANRVFKPLRLSCHTCHRIFRNLSGLTKHIHTFHARLHGHTLPQATHRAAINNEANVTAQPLDNNPQHQVLKDGRLYHLVHPDMNGRPCDSKGRFLEDPTSQPSCRTESITSDWTPFASRLQFETADFLFQRARMSQGSINQLLELWAASLIPFGASPPFASVQHMLETIDSIPFGDAPWSSFKVRYTGDLPPNPPPWMTAEYEVSHRDPLVCARNMLSNPDFAEEFDVAPYREYDSSLKRQYTNLLSGNWAWKQAVRLCLTLGRCVINEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PND0</accession>
    <name>A0A2R6PND0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v4547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PND0"/>
    <dbReference type="STRING" id="98765.A0A2R6PND0"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR94119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="516" mass="55745" checksum="892B25A73868BE1F" modified="2018-06-20" version="1">MSARTAAPAVRTANGGSGANSAFNDKGKPMEVRLSNMVAAKAISDAVRTSLGPRGMDKMIQTPKGEVIITNDGATILKSIQALHPAAKMLVDLSAAQDVEAGDGTTSVVVLAGSLLGAAEKMLQKGMHPTVIAESFLKASAKAVEYLEELSTPVDLKDKSALLRAATTSLNSKIVSQYSSTLAPIAVSAVTRLVTPTSSNVDLRDIRIVKKVGGTIEDTELVDGVVLNQNVVNAAGGPTRMEKAKIGIIQFQLSAPKPDMDNTVIINDYRQMDKVIKEGRQYLLNICKKIKKANCNVLLIQKSILRDAVDDTSLTFLKRLGILVVKDVEREEIEFLSKSLVCKPIADIDAFSEDKLGYADLVEETNENDVKVVRITGVRNRGRTVSILAMGSNNLVLEESERSLHDALCVVRCLVKKRALIAGGGAPEIHVSRLLSQYAQTLKGMEAYCFQAYADALEVIPTTLAENAGLNPIAIVTELRNRHALGERNAGINIRKVCIILEKRFFPCAHTLYRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVF9</accession>
    <name>A0A2R6PVF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVF9"/>
    <dbReference type="STRING" id="98765.A0A2R6PVF9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR97578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="15779" checksum="617033AA8038997C" modified="2018-06-20" version="1">MAFSHSVRFELDSPDGIAEWAAIIPGDGLVHLGEQKEPYTISMMHQLRCLDILREELVRERDDSEGPSTLSRHCLNYMKQMVMCRGDIELEPFQYPNHKDPIDMEGIYECRDWSAVYTEVEKNQVEFGKWLEQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVL1</accession>
    <name>A0A2R6PVL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000441">
        <property type="protein sequence ID" value="PSR97288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVL1"/>
    <dbReference type="STRING" id="98765.A0A2R6PVL1"/>
    <dbReference type="OrthoDB" id="2796803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR97288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="383" mass="43162" checksum="3F02D02AF32E3515" modified="2018-06-20" version="1">MSPDGKSVLSVCKFGTIRLWESSTDRWRTVWKFDNDHSDENDSNEDDSNEDDSNENDSRNHGERATIAFSPDGCRFACVFDDELRVQDVETGEGKMRSVGDTGRASVVGTVRFSPDGRNIAVEVWEETWPGYQRQVINTETLEDVLRVTSSHIAFSPDSTHLASSDTQDHIVVRQMNGNIVQSFIPFDNFTNAIEFLPSTTGIYLATASRDTITVWDMSCLTGTPTPVLRFSCFGGSVASMACSRDGKRLVAGYADDLVRVWDVSINDNPAEHSTMPICFSTTPEHALPFSRFLMEYDPIGEHQDRNGMILEQRATVRVCIYQPDLEGWVVSPSRCRLLFWVPPEFRERLLMPGQQLVLGVEHLELDLSQFVHGPDWVECYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB64</accession>
    <name>A0A2R6QB64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000374">
        <property type="protein sequence ID" value="PSS05366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB64"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="100" mass="10812" checksum="76E3E2144802C0A1" modified="2018-06-20" version="1">MCQGELRKRRVCTGPNKSANSLQASGKANAAAIKAYAKCHGIQRGGTKKEDGRPTGDQPPLNLEAKDEGLLTFVQSISCRRAIWAEAFDNQPPDPCTWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB82</accession>
    <name>A0A2R6QB82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB82"/>
    <dbReference type="OrthoDB" id="3229881at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="9808" checksum="710541DC7376B17B" modified="2018-06-20" version="1">MCQCFASLDFACMMCLLEKIACVLALSAWISAVLAIPAFEGVSTWSSIGSLVPGMSYLEALGPTNLNENSSPQYVSIAAPHGTSGYTSFHITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB84</accession>
    <name>A0A2R6QB84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB84"/>
    <dbReference type="STRING" id="98765.A0A2R6QB84"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="328" mass="35217" checksum="83BD5B2E1AE759C5" modified="2018-06-20" version="1">MSPNPNSPPGESATDLWFERSNFDGAILGGVAYGAGRRNLEFLLLSILLLTGATINLAGNGVLSEEAWIDDRGVDGGPIAWLTTACVGPNCALGNYGYIISNFFADGLLLWRTYTVWNSVFIIAFPFVMFLASTGLSIIGVYQTAVPGNNIWSQVSISFLLPYLSISISLTIILTLLIVGRLLYTTRLVKTAMGEDHAKMYTSTAALIVESAAPYAFTSILFIIVFARGSNVQNLILPILAQVMCISPELIILRVARGNAWTTTTTTCPPATTVRFKAGAPRRNDRSGETTSVILTDVILAETGDGRSTLASSQYIVKEDSDARGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBC3</accession>
    <name>A0A2R6QBC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000372">
        <property type="protein sequence ID" value="PSS05429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBC3"/>
    <dbReference type="OrthoDB" id="2576311at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="312" mass="34437" checksum="7E91024C15803657" modified="2018-06-20" version="1">MKCVPITEAHGWSAIQIATPIIVGVGIITLAIAAFLIYRHRKYNHSSGGKRRQKPWESAHLHGPRRFFGLLPDRFTVRSRPTKEPQWEIDEQALQDTDLEPSPSSQGAASNNQSRPDMHSMHLRTTSTTSLISNMSHGTANRSRSIFSALTSKFNVFSPRDYSSGTTKGPDYKRVQVRSEHPDRRFKIDGGELTPRESAFSFPPPPPSPPPPERRDTLPSVLDIRRPSTAGGSRAGGQARNGSLPTTYYDDRTDLTSPIAPKSDYSLRTTDLQTPTSLSGSVPGAPFAYSTFSHIPVLASLSCQDFYFTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM77</accession>
    <name>A0A2R6QM77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM77"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS11028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="6263" checksum="F6FBB136974E72AF" modified="2018-06-20" version="1">MLRSEKQTVAEEFHSRHEGLRRQDVQVDGVQFPQRSESELLLNELEANRIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI76</accession>
    <name>A0A2R6RI76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI76"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7320" checksum="98741C8162B3CD91" modified="2018-06-20" version="1">MRTVTPNETGGNTQPLSRRREGRKEEECLERTGIALVADDRKKSWANVQGWHSGAFLHRWAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLI0</accession>
    <name>A0A2R6RLI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000243">
        <property type="protein sequence ID" value="PSS30874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLI0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10246" checksum="149BC581BB31119C" modified="2018-06-20" version="1">MSGFPLPPALPVQSFLLDDHYLEFEKIMSQGPITFTQTAYHAPVAKAICMQASISNGRVHAEVFGNFSDDLAEHVMLTIPPNLNSGTWPEDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLM5</accession>
    <name>A0A2R6RLM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Signal transducer</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLM5"/>
    <dbReference type="STRING" id="98765.A0A2R6RLM5"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS30933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23377" checksum="9773F6036F98E127" modified="2018-06-20" version="1">MDSSSYPTSRPSQPARRPDIKKKLVVVGDGGCGKTCLLIVYAENRFPEAYVPTVFENYVTQVTFEGKLVELALWDTAGQEEYDRLRPLSYPESDVILIVFSIDFPVSLANVQDKWYPEVAHFCEGTPLILVGTKTDLRKDEQTRRMLGAQGQTPVTPEQGAAVAKEIGAKYIECSAKTGTGVQDVFNLALKESMKGRWGKIVKQRRCIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLN8</accession>
    <name>A0A2R6RLN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000231">
        <property type="protein sequence ID" value="PSS30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLN8"/>
    <dbReference type="STRING" id="98765.A0A2R6RLN8"/>
    <dbReference type="OrthoDB" id="3271139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="609" mass="69107" checksum="60B599B2B96FB0E4" modified="2018-06-20" version="1">MREDPRRRFTFGFTIEDTEMKLWYCDRSQTVASQPFNFITDHETLIHFFLSLSYASPVQLGWDPTIAIQEHDLQYRITVQSGDGTECVYRTLEVLSKSSASVLHGPGTRVWKAVRVVDGHDYGDPVVLKDCWVSCDRQREGTIHERLRNANSSDAFREAFENMFLTVEQHGDVVIDPGIQRQPDLTPLIMPPEEMKKNGYNIPPVSATLKPRAARSLWREITYTKSRHERKVHYRIVFKEICKSIKHATSLQEVFKALGEICSALKLMHQTGWVHRDVSIGNILIDSHGKARLSDLEYAKDMKDTNDPEFRIGTANFVAVEVQTQQYAFRPLNPPSVSPASDTRSITSDDLAEKRSYLDSAARPHSDSSSDLSISPPLFAFRYNPLHDLESLWWIAVYFIFTTEVANYADLDEKGQDRQLGLDGCVLRLFCDFEERKMDMIDGWDRRFLDRCQCLHPSIRPIGRDLERLRVVLVTTYAQCEANRGSITLEPLEGLHDSIQELFFSISKEISEEPTLAHVLPATNCHPVPRPVQPGSSSHNTASSSGKRSRSDSSDEESATVGNGTPIASTSLSGSRKRARIEREQEESAPRVGMQTRSKTRAQTNNRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPK7</accession>
    <name>A0A2R6RPK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000212">
        <property type="protein sequence ID" value="PSS31956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPK7"/>
    <dbReference type="STRING" id="98765.A0A2R6RPK7"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF131">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="38"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="753"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS31956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="846" mass="94732" checksum="1A9987BA8EE27C24" modified="2018-06-20" version="1">MALTSEVKTLNAESSYAQHLQLLLTLINQLRAIGAQADLDLPRIAVIGNQSAGKSSLVEAISGINVPRDVGTCTRCPIECHLSNSGDSWSCQVSIRWEFNGDGTRRNEVQEIKFGSTLTDPKDVELVLRRAQAAILNPETSMQHFVTKTAKELRVQQRDQIKFSRNTICVDISGPHLANLAFVDLPGIIQNDSEETVKLVKDLVLSNITTSNCLILVALPMSDDLQNQGAMSLAREVDPSGLRTIGVLTKPDLVTTKQQKELWQEVIDGRREPLKHGYYCTRQPDEDDRMNHITQEEARATEEEFFSTIAPWSTSTHRSRFGTQNLVQNLSMLLTKIIEECLPKLIEETNLQLADCQTRLHALPRPISSEPTSFILNLVTSFCGAIHAYVQGQSLSATLVQRTRRTYGRFKGDIKATVPPFLPYADEKSAGPISREAFQLDEEDEDKDVSASNIIYLNDVRKRIEEAVTRELPNNVPYPAKVSFILEFQSRWEEHARKCTKAVHDHLQDTTDRLINHTFGGYGHLEPRIRRSVEELLKSMYTDTVSQVLKLLKYETSPYTQNTHYLSASKEKLLAHYKDLRATGAKPSISHTPATEPLNQKPTAPFSFQREATVSAQNNPFYVISTTKFEPCGFRWSSPGTKSTPYTETIISDNAAHITMGDISCMPAFQNWSSEELRTADYGYTKKGAAGFGQPSMPQAVESPTPESTGKVSQYERKEEEDRILAGLAKLGFHGLTAADFGKLVPTDEFQEELEVMAEVCAYFKVAYKRVIDYVPLAIDHDLLYAFSESLQAHLVEKLGLGTKDAAEKCAGYLEEDPHIKATREELSVRKKRLESVYSELTSFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ23</accession>
    <name>A0A2R6RQ23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000198">
        <property type="protein sequence ID" value="PSS32095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ23"/>
    <dbReference type="OrthoDB" id="2843772at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="532" mass="56856" checksum="48A8915C39021DC4" modified="2018-06-20" version="1">MSLETLSSARAADNNTPSTAGLLIAVPSSSLDLSPVETAVTTSLPSAGKTAGSIATGSFSAGSSSPSSPCEKFASAATVAPASRAMLSGAAMPTAPTTGSPATSPPDMPGVTGNIVADKPGLSTTSPTSAVFNRTSSSGSLPVAEPQTPKRAPLETLYPTPTSLGSPFSSPTFTGSPDPSTPSWGHNHPFPSTPSTPSESSSASPLPLSRAPRPGVPFVPVTAEQGAEYTAEKMLWYRDRLLRRGTYLGDPDFDPVTVLAWVTVGRTRILCTKEVAEEYSMEFERYKADTDNIARPAPPEGACLGGVYSIDHSRFYMTADANWYKGNRFNEEYADAKATCLLKAASHFVFAGDFPTMERNLAKIVDMARGGANRELKGLYGISEGGKSLLKVRHVLFEPLSKSPPADDGPTNNEFTVAGWPARKRDARAALHDMRDTHRVNVMPAYDAYSVQILPSRYEAALRGADVQVYFSMLHWAIGQGEVINSDTMVCDVRNMRVTIPPRAKMQPRTPTKRVSQTDPFTPAFTKKHRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVI0</accession>
    <name>A0A2R6RVI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ku70/Ku80 N-terminal alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVI0"/>
    <dbReference type="STRING" id="98765.A0A2R6RVI0"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku70/Ku80 N-terminal alpha/beta" evidence="2">
        <location>
            <begin position="51"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="15092" checksum="C750C6E1D8938684" modified="2018-06-20" version="1">MAPYDEWNKIDDDDDEELQDTSVSTSSEQGTSQRFVNVCTHKFFEGKRDVILFAIDCSESMLELREDPNYEDVKTCHLMAALDAAVQIQKKKVVVGPNDAVGIVLFNTVSEQALHLTGSRATFATHGEQFTDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZF9</accession>
    <name>A0A2R6RZF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZF9"/>
    <dbReference type="STRING" id="98765.A0A2R6RZF9"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="173"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS35411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="883" mass="98619" checksum="F16AD6294FF1FD5D" modified="2018-06-20" version="1">MDMYQELDPAVQQHLSLESFEGKFDVKEFVAGISERLISQSKASSGPFDPKPFIRTLEAAVDQLITQRKDVQARTEQMEKSVKVAEREYSKKMAELNRGFEAVGQSFGGMESKMNEVGRTAIRIGEELESVHHQRQRAQAAYDLIDFYNQFSRDDNARLDALKKEGKEGRRQLAVLLRRLGTVAKEVDLPNADKTRENIDKYCEKFEKDMLHLFDRAYRRGDPKMMHHCAQTLLDFNGGASCVQVYVNQHDFFINRVREGSGNQDEEIWDNLPDPDAPLPTTESRLAELFQEIRTTVGQEVQIVQAVFPNPAYVMQVFLQRVFAQSIQQQLEQLVSRGTSLSDLAFLRILQMVHQQTSLLVEDLKSYELPSIIPRSPIDRTDFNQSLNAAASGAVAATTTAVTISAMLETAMEELFVPYTEGQRYLERESKSLSELYASFLTNFTRYHERTHKGGKSSLFDRMVNQLSTAAAAGSAGGASTTSAQAAAAILRYGGLSASAERNKEKANEEPVREEDGQLHIAIAEIMLKWHAEAVGRCVELSSSSDVPKHIFALLRVLAAAIGSAYIETAIETAQTRVESADPKAEPSLQPLTVLHSIDLICHLWQQYVNMALLPLASTSVTIRREMVVFNNQTVSRLEGAANHVMQKLTDSIITWLSVHLSKQKRSDFKPRNDDLSFARVNTEPCVACCETLEKVRDAAKENLSGKNLEVFLTEIGVAFHGLLLEHLKKFPVSATGGLMLAKDIKSYQDTISSFGIPSLLERFEFIRQLGNVFLVRPDILKSYITEGYLGRIDSSLLRPYLAQRSDWGQAEKGFNDSTGVEDGPEGKGLRDRFGMGRLSMIMKDLEPLRDQLPPMSMPSLPAGMSMPNLSMSTRAFTSNQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S006</accession>
    <name>A0A2R6S006_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000111">
        <property type="protein sequence ID" value="PSS35611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S006"/>
    <dbReference type="STRING" id="98765.A0A2R6S006"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS35611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="350" mass="36882" checksum="B5EB7CF37A43C445" modified="2018-06-20" version="1">MATIPTSMPATTANWHWKNKNVTPWAKTWFERELTTISVQGDGGEVSISQVTEVDGDVELGQRKSKLITIYDCKVELNWTGKAADGIEVAGKLTIPEVSHEITLDGLSDYVWNFSLTTASSPAVDAIYKLAKSRLPVALEAKLSEFPSAIINTHGKDLTVSADPSRSGTPAPSSSTPTATGGAPTSAPAVAAKVAPKKVTAKAVNSTTVTIDGAFMASADDLFSILTDEKRLPSWTRAPAQSAAKPDTEYSLFGGGVKGKYISLSPPKEIVQTWALSSPTWPSGASLSVHGLKSIGYVQLSLYTPPPPSRKSKAATISKPQPAPSSHPYVALGLAALALAAAFTIPYVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3F0</accession>
    <name>A0A2R6S3F0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 8"/>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3F0"/>
    <dbReference type="STRING" id="98765.A0A2R6S3F0"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS36810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="436" mass="48261" checksum="5657F584DB1338DF" modified="2018-06-20" version="1">MSPDATTTSPSDWRYIAEGGSSIVFFYNGPPNPDFDATALRLRKTANDVFPVIDESVEEEEPDDPTILFQHQVIQRLMPAEYLPRLDAVRVGKEWLEELKKLNEEIRPLERREKDGIDVRKRKAVLATDLVGGTNGFTVEIKPKWGFLPSPTHLSIATRPVKTNTCRFCMHSHLKSSEGEEVSLGYCPLDLYSGQEDRIKKALHALWDVWIGSSGSVNNLRVFVDGQIVSPSLLPSSLAPLAKKLPLPDPSSPPSLTGLRDAFTDAILPLLMDIPVLRVLSTLQRNLDALDVEGLSVLWSQAYASVNAQAVVDGGAGGSLPVPPLGTGLAEPTLEDWKAFLDIYLTKHANMDHDHPDAANIKYYCMAYLLSTSFKDCSIILRLPRDGANTVTVIDLDVKPVDRMSKWEKLDKKIVQSYSSLSEPTHCVDQWASQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3F4</accession>
    <name>A0A2R6S3F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3F4"/>
    <dbReference type="STRING" id="98765.A0A2R6S3F4"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015354368" evidence="2">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="13838" checksum="6D6BC8D3F2737961" modified="2018-06-20" version="1">MRATTIISTFCVLACTIYSPASALPSNSGSLAARAPSPSIVARAPQPSSARRMEARAPMPSASLKKKREQHVIVSAEEQISRQLCPTPMSVCPITSARPSTLLGWIADGYECVDQQEDLTSCGGCGIVDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3X1</accession>
    <name>A0A2R6S3X1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3X1"/>
    <dbReference type="STRING" id="98765.A0A2R6S3X1"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="51088" checksum="89781DA390B4CDE3" modified="2018-06-20" version="1">MDNRSTTASDTFAHTPVNRWRTRRLSHSHHPRPRTRYTLLDCKIIIPLILLPLYLFFWLWEPHVEFALYSRRWIRNEVEALHPLAGCFDAHRVSHKYNVTQSLYGAKKNEIHAGMPMRLGMDCYNFAGTIKSNHDIPQRWIPPDERMQFHTYWRSDLAHFGERQEWMVKSFFATQNTDTSRLVLWSNGDLSQNKIVQKWIRRYPDAFTLKLVDLNKLAKGTSLEGSKLLKLKDQKAWIDGDMVRLLVLWAYGGVWVDMDSLLTRDLSPLLEHEFVTQWDCYDKTYIPFNGALMNFHQHSPYLCEAFHIMSNGPPPRTGTTDWGATLYLKLWRRLIEATIPPFKVLPFCFSDGRSCRLDNRLPDPFVTDPSSGKWTMGMGREEGGGLDRVLGKIFSVHLHNQWEKPFPKSGWVERLLLKRYEEKLRRIKPRAAGDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S438</accession>
    <name>A0A2R6S438_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S438"/>
    <dbReference type="STRING" id="98765.A0A2R6S438"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS36979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="182" mass="20049" checksum="873E3E0D86CD3217" modified="2018-06-20" version="1">MGIFEAGFERPSPIQEEAIPIALTKRDVLARAKNGTGKTAAFVIPSLQQIDINKNKIQALLLVPTRELALQTAQVCKILGKHMELQVMVTTGGTTLKDDIIRLSETVHVLVGTPGRILDLAGKSVADLSECPVFVMDEADKLLSPEFAPVMEQLLSYLPKDRQVMLFSATFPMIVKDFKVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4E6</accession>
    <name>A0A2R6S4E6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4E6"/>
    <dbReference type="STRING" id="98765.A0A2R6S4E6"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000524">
        <property type="entry name" value="Cell division protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="384" mass="43479" checksum="CF9F103D5C051FCE" modified="2018-06-20" version="1">MNYVQGRSRTTNEIVALKEIHLDAEEGTPSTAIREISLMKELKHVNIVRLYDVIHTETKLVLIFEYCERDLKKYMDAHGERGALDPVTVRSFMYQLLRGTAFCHENRVLHRDLKPQNLLINRKGELKLGDFGLARAFGVPVNTFSNEVVTLWYRAPDVLLGSRTYSTSIDVWSCGCIFAEMISGVPLFRGRDNQDQLLHIMRIVGTPDDRLIRRITNENNENQQTPQKQYPRYPKISFAQVLPKASPEALDLLERLLQFDPTKRITAAEALNHPYFTTSGPPVPMPPPGNMAPPAYNFPHPHQQQQQQQQAQQAQQQAHAQAQAHAAYLAQQGMAQQAMGQPVYGQLPPGQRPPQAHPQTQGMALSQQHQFMPYAQQQYGTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4J7</accession>
    <name>A0A2R6S4J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase ausD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4J7"/>
    <dbReference type="STRING" id="98765.A0A2R6S4J7"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34313" checksum="0D893EF906717314" modified="2018-06-20" version="1">MATTSLELKIVDPNSIRRPLDEKCYNLDNAEEEFIMRHTGIQDPQEVKKHVIAVQAEAYEIFPYPCIFMFGFAKLKISRFPAYKELLRLGKERQGALFLDMACCVGNDLRKAVADGFPVNQALASDLEPGFWDVGHKLFKSTPETFPVPFIPGDAFDSAFLAPATISTSLPDGPVPPLSSLTSLTPLIGRLSVIHASSFFHLFNEELQLQLAKRMGSLLSPEPGSFIFGGHGGFLQKGPRSMPMSAAVQSITMFCHSPESWKELWEKEIFSQGKVKVEVYLKEVQRQDLPAEESATYHLMIWSVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5E2</accession>
    <name>A0A2R6S5E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5E2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="7645" checksum="5B137EA18CB96C6F" modified="2018-06-20" version="1">MAPKEGLIAVPSRLVSSSMPNNGGPPHRRASLPSSGRCQRPPYIMQSSQSRPPPPPASRPSSAPAFSPLTDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5J1</accession>
    <name>A0A2R6S5J1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000038">
        <property type="protein sequence ID" value="PSS37536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5J1"/>
    <dbReference type="STRING" id="98765.A0A2R6S5J1"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="281"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="387" mass="40610" checksum="535EA4D8B828BB70" modified="2018-06-20" version="1">MKTSHLASSLVYVFSFLNLLQIHAISVYLYPKPSSPVPERLDAGHASLALARHLGLERFEKLGDGDGIWNGALEANGEGWVGTASKDALLITLSEADAKELLPSSFESTFQLSSPPLDSLSPLIQAYLSRAAHTYSTVFSTASSTISQQAAQLLDMFSAPTEANQAFLTSISALVDFLDSQPSEPSVTPGYENFGAFEVNGLQELAKQYGKSSDPYQTAVKTLQAVFTSTISREDTKFAILTFPSPSPSPSPMTRRADPPQSPFPPPPVHPAEPISGVSTCFSSAEVCGNATDGCTGHGECVAASKIGRTCFVCACSASVDDQGRREDWAGTACERKDISGPFVLIGGTVVALVLLVGGSIALLSAIGSQELPSTLTGGVAGGLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5X9</accession>
    <name>A0A2R6S5X9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5X9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7027" checksum="F5B5E22A7E2F525B" modified="2018-06-20" version="1">MFDVSEAEAYQNMPCIFFGALLAPGINENSGQPSCQPRLQKENLLLAETLIPRAFLELWLCIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6V4</accession>
    <name>A0A2R6S6V4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6V4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="16022" checksum="D176C78B016504DB" modified="2018-06-20" version="1">MFWRRSRSPKYDSPEKAEVPRDETPRPFPFAYPSPQGTAEQTASLPVSQMQAVPVTSIVSAKMREYTRHVNQYSQSTPSSAYTSSTDPSSSRVPPTVVSDSSQTGSGSSPLSPQDVQGLRSEVENLRRVMESIQNERLEPPPSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7H0</accession>
    <name>A0A2R6S7H0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000001">
        <property type="protein sequence ID" value="PSS38149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7H0"/>
    <dbReference type="STRING" id="98765.A0A2R6S7H0"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="14"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS38149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1045" mass="118004" checksum="AB29BC00514BAC2F" modified="2018-06-20" version="1">MNTRFSAVGMPVGWAAIAKTVRDIDEDKIRNCKEDIDTLLVFAGLFSAVLTAFLVESYQTLSEDQGATMIQLLRQISSQTHSYAITAILLNSTAPPLPTDATPFEPPLFAIRVNVLWFASLIFSLITASFGMLVKQWLREFLSGDYTSPKARLRVRQFRFPGLLDWKVFEIAAVLPLLLQLALGLFLLGLCFFTWEVHPSIGLTSTPLVAGWALLFASCTIAPAFSSRCPYQFALLKRAMKSLRRLLCSNTHLGWLYAGPRGVIKFATPFEDADAATDEKSDVEMLAAVDAILLDDDLLGTTMWESLQQNETKLSDTIRFILGALRRRLSQRFSPSSMPRLLDLRQLTKQGWEAVVNVTAQSLIYSVESGHSKNRDWINWAIAILLSHSEYPLTIIGRNALVASFQESLVSTCNSIAVVSHHEHGTNLNESFTHLFERLGGALGLLKPEAVTHSIFTIVRQHLELCRTTCFHRIPSLADVLFHHSDSTLARETISPILLKCLDQNLSNPGEDVWTFGTCTEILAALDAILLDDALLVTKIWPSLKQNRISPSEIVEFVVGSLRRRAPFASISNRSPQILSLHSLAQSAWIGMIDIVADLVNSRSAKHVRFESNSDSILVAEEDWEVHAFTLLLSKSDYPLTSDGVRALESLFEQMRKTVVGGTSVVKPSSVLPPNPSLTYITQVFRKLRETFPSSDPECMMQHIIAITKFHPICTVSCNHHSFGDVLWSHSSQLPVDDMLHILMDCVIEHFPDSEDSMWTPWAEEIFDMVYLLHDLLSDPDAMNLKLRSAIQRSLPQTHLIRPMMVIAANRTMQVRSAHIFSWIYDECDTPNRLLLLGNLSFLVKGLTAVQEDAEVIDSSLPGPLAMCHFTLHVLDDLSDAHGFLEHWKNLWVDLSIALKCFRPTVQGSSEEHHKIAAACLSWIEYLEDWMDSKEWFLDQDMYKLWLERYKPEKSFFPEELIEALGMFIPNTSKITNCKRLKRLRDLDLQDTTNDSQIEWDYWYRYPGRATAPYPQPAEIRQTASLMNWLKPWRRSNSTVVIAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDW1</accession>
    <name>A0A2R6NDW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v13620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDW1"/>
    <dbReference type="STRING" id="98765.A0A2R6NDW1"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR70469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7344" checksum="019E583B7DFD15E3" modified="2018-06-20" version="1">MANAGPGTNGSQFFITTTTTPWLDKKHTIFGRVLSGLEVIHSIENVKTNKVDKPYEDIKIINIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE01</accession>
    <name>A0A2R6NE01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v13532</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001347">
        <property type="protein sequence ID" value="PSR70594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE01"/>
    <dbReference type="STRING" id="98765.A0A2R6NE01"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR70594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="16272" checksum="D826BDE275D7CCAC" modified="2018-06-20" version="1">MADVSDSKIDEAYNDVRSDKTETNWLLLDYETDRSDVLQLTATGTGGLEELRDKLDESKASYAYVRVRYSNDKESQREKFILVVWIGPSCKVMRKAKISVHAADVKQVLRVFSIEVPAREKDDLKEEPIVVKLRKAGGASYDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEW9</accession>
    <name>A0A2R6NEW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001302">
        <property type="protein sequence ID" value="PSR70925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEW9"/>
    <dbReference type="STRING" id="98765.A0A2R6NEW9"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="408" mass="42634" checksum="DEEAF96C9C8452E6" modified="2018-06-20" version="1">MKVGGNASANEFFNKHGGATLLSDSDTKKKYSTRVAELYKEELARRVKEDAIKFPTRISVDGLPDSTATPTPGSTVGAEGEDDFFSSWDKPVAKPASSSASTPAAPPVIGRAASASPGPRTVTSSSLRSSSTTGSSRPTSKLGASRLSSSPATSTVSSPAAGSAPKKSKLGGLGAKKAATPFDFAEAEKKAAEEAERIKQLGYDRERERTEEEERARKAMSDKAAAAAVARTSAPVNGKTATTTTPVENRPLGSSQDMERLGMGMKRLGFGSVPVAAAARVSSSVDDPTFAREKFGNQKAISSDMYFGRNAYDPAAVNEAQSRLQTFQGASSISSNQYFGREEEEGAGGHAGGESTLGDGTLSNLEMAARDAVSRVMANPDVQNAADSIRAGALKLHLYHGRRGAWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFZ4</accession>
    <name>A0A2R6NFZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFZ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NFZ4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="9824" checksum="69D5212E5270737A" modified="2018-06-20" version="1">MSAASSSSSQIITAAALIAASLGVGYAFGLKSAPTPHPPKPEVSPKIPPQQEIPPHTNDSESDSEEEDDVADGDLSAVKPGFLEPCKLVSAFHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG27</accession>
    <name>A0A2R6NG27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG27"/>
    <dbReference type="STRING" id="98765.A0A2R6NG27"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="8219" checksum="4842ED33C3229DCD" modified="2018-06-20" version="1">MKDYFQCLPGAATSSAPTSTPISSSSFTTPSTSSIPTSTSPATPSQTVSNISPEWAAAYTKAQAAVANMSLNDKVNLGTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGD5</accession>
    <name>A0A2R6NGD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGD5"/>
    <dbReference type="OrthoDB" id="3256745at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="245" mass="27438" checksum="5370C4CF88BF7323" modified="2018-06-20" version="1">MRLFRPQARQELHQSRPPSHAVFQQDSLTALPPRRMRTRESKLSTRFESSQLTVQDGSAPAYITSSPKELQKTLVPDSPGRSPSMAKHSRYHLPFHTTPPPSAPHSRKPSIHSQNTDTARDSPLLDAIRGSHPHPPSPIIFASPSRAESQNHTVVVTISPSPLPDNGFDDVKDDESIQVRPIELDMNADDGVSGSLRWARDSDRGSIGKNEFVYITRPEDEEDSSTYAFPPYPRIRRVASGRKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGW0</accession>
    <name>A0A2R6NGW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGW0"/>
    <dbReference type="STRING" id="98765.A0A2R6NGW0"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="487" mass="54970" checksum="B96CA882A1D76BC0" modified="2018-06-20" version="1">MANICCHCKNSFASRAGLKSHRKGCKERDASLQSSVNQRNLRIKEGKAKIQQRGQQDITREREQLREHLNQNLDLIHPDIAPDVQDAYMRSPTPKPAETTHILPPTRSGRIRKAPRHHKDFIPSTTTGQLHAHISRLVPPPMTPIHPVPLPVDPPSPGVDVKVSNHRVGPNDNLPETATVYETEPNDFGMYRRYGRKPSQDIAQEDHDDSLCDSPSIATAPSSISSSPLQSFGRAVVNGIGKIPAWFSPFTNASIFRIMHWAYTGSNQKSTAEIDRLVHQVLLAPDFNKEDLQGFRMGREEHRLDDHTTASSPDLPVDEGWHEADIQIPLPKEKTKHQSEEQAPHLKIKGVWHRKLLDIIVAAYRDKSVRQLTSIPYQLFFQDTNSNQMPERVYTEGYTCDALVEEDAKIQALPRNPEDQEDVEYSIVPLMLWSDSTHLANFGTASLWPIYLYLGNLSKYLRCKPSSFAAHHLAYIPSVSFSLKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHK6</accession>
    <name>A0A2R6NHK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHK6"/>
    <dbReference type="STRING" id="98765.A0A2R6NHK6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="25324" checksum="DE0000EF8DE7F092" modified="2018-06-20" version="1">MLYIPVEDEDQMGRDFFGFLENLVKVFPSLKTRPLYLTGESYAGTYIPYITKTYFGLENPPVKLSKIAIGNGAIGNFWEYEVLSTLTVIETYPQLIGYDPDVYKYFREQSHLCGYDLNLTYPQRGHFPTLNPQLPTFTNSDRAFKKSIVKEALKVDAQFARSNLKARGLELGSERLEKRDQWKRELTGRPNGTIDPYYGCDLYDEMIDYALNFSLPWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHP6</accession>
    <name>A0A2R6NHP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12127</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHP6"/>
    <dbReference type="STRING" id="98765.A0A2R6NHP6"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="346" mass="36150" checksum="D1141701594D6C4E" modified="2018-06-20" version="1">MPDAASPSTKRQRLEPIDPSAPAMMTTGDDAFIQDHDAVESGGDDDDEEEKPKSDKKAGRRKIKIEFIQDKSRRHITFSKRKAGIMKKAQTGLVYTFTTAKLQPLVTQPEGKNLIQACLNAPHGQLPSSMPVGTPLGRSSGPMNVNNPHTPSTPSAPPNVPGGLAIGGKDEDSTDGHDGHEQVPGMPEVGPPPETNERASRKRRRTSGATTSPGGRGVAPAPPPSAAAAPPPTATSPQQTSPQQGPSAPSTSPHSRSAMPLPNPLAIPPGPGPTQQAQMQPQSPSYTAYPSGDPNGMYAGYANQPPPPGPPQYGYPPPPQGHDQQQAGMAWGPAPGVQQGGHYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI08</accession>
    <name>A0A2R6NI08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI08"/>
    <dbReference type="STRING" id="98765.A0A2R6NI08"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="312"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="587" mass="65757" checksum="E39837DEE50C22DD" modified="2018-06-20" version="1">MAPSRAKKEPASPTPPSDDAAPKDSSENSKIKRNYLRRLQEAQAAQAASHQDGTNGSESVQSPTSTTQKSASPSHTAMSTSPQLPSPYLEPSLSSIPPPMLNGSLPPSRYPIAADGFHAQYPTMSSLNPSTFGQPNGIHSRSPPREEPSFTPTEQFSTYPLFNWSFKQHQALPIPPPTAIPPLSYYYRPHRLEDIAPRDTILLIIALFFDFVYPLTPCVHKPSFMADVHARREERDPLFFALVMSTVASTLVQVPRSYLPMERHAVRKLAQTCHEASRHISVASYDPPTSMHVVVRYFDCVYHFCEGHDATQHAAFGETAHIAVTLRMHEESSYEGLDPIECEVRRRTFWLLFGADKSMSILLGRPICLRDEDTTCNFPRELDDEYITQSAYLPQPHGKTALVSGLNYISRIFALLGEILVRIRVDKRSPPQGQFLTARLEEVQALHARIVTALAHTPEPLRLKHAHSQSHIPPEYGGAGFRQATFAEVKDFFDNPNASRANALNPFLVMQANLYVTQVSRGSISHRLIETWAAYFSAFLPRQQLVRFVIEQYRDELVTSLQGAIDESRVAEDREAVASDLLNILHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI36</accession>
    <name>A0A2R6NI36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001223">
        <property type="protein sequence ID" value="PSR72057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI36"/>
    <dbReference type="STRING" id="98765.A0A2R6NI36"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="271" mass="29317" checksum="31F704CABC583630" modified="2018-06-20" version="1">MCLLVTRAPTSSLASASLHELDRLCEFFELIGEKSQTATNNLVQCSFDCVKYQILRIDAPQEVVQKLRRQAHDAANNAQSADRSHPLSTELDRLGGKTHLISSGHSGMVSVPSPASSNTSSTQSNCIGTPGPSTAATPPFDITANCSPIPPDQIHPTIISDMRSFEEFSMTGPDGDQIMSIPTSFNFDLAQAFPLPQERQQPPDYATLEEIQRFFGDDFFGATATAASASAAVLPPYMLAPPNMEPELNMLPVNVPVLDATWQSFVEQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI45</accession>
    <name>A0A2R6NI45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001222">
        <property type="protein sequence ID" value="PSR72065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI45"/>
    <dbReference type="STRING" id="98765.A0A2R6NI45"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="378" mass="43716" checksum="E1781F0BA95E3F73" modified="2018-06-20" version="1">MLKKDDRRQQMVYYQAGIGTYTSPHIATPIVNKMSKIMDGAVAWNLSAHVLAGYEFLMQNYEAGDKICIFGFSRGAYTARALAGMISTVGVLPACNHQQVPFAYKMYKTKNWHQTSKFRETFSMDVPIEFLGVWDTVSSVGIIGRSLPFTMQCRTLKTFRHAISADERRAKFKPNLFRHPGDSPWQTDVREVWFAGCHCDVGGGSVKNDVEHNLARIPLRWMIRECFRTNTGILFLTKSLRDISLDPDSVYPEVIVRPEPLYTPPILPPVAKKQKRALTEEEADAIDALCPIYDQLRLKPFWWMLEMMPVKRWVRTEEKKWLKEYTFMNLGRGRKLYREGSDGLFLHRTMKIRMEALDLKDGPYLPRAKFQTEPTWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI99</accession>
    <name>A0A2R6NI99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001220">
        <property type="protein sequence ID" value="PSR72089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI99"/>
    <dbReference type="STRING" id="98765.A0A2R6NI99"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR72089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52851" checksum="31029983B0F1826E" modified="2018-06-20" version="1" fragment="single">SPDIVSFKGTFSTKHHPPETSHSGSFIEKASTHDSGSIDVVHGELKSLDVGLALVADRSEDADLSPQESKRLRRKIDWHLLPMLFLIYTVVLRFLLGASEGSMTAGLMLVCSMFYTRTEIGERLGWTFQCNGLAVIISGFLQFGIAHTSPSLKPQQWQWLMLTTALITFMPFLLFLLFFPNNPTNAWFLSEEERIRAVKRVKENQNGIETKVWKRYQAAETIKDPKTWVMAFMAGFTAMIGGVGVQYALIIKNFGFTQLQTALRGIPGGVAQIIAILLGCYALRRLPNSRAWISIISWIPSILGCLIEICVPIENRVAHLVGIYLLFSGGSPAFIMSMSWVTSAVSGHTKKTTTAALFLTFYALGQTLSTQFWLSKYAPRDRTPFGITLMSHLASILCTLLFRFLLVRENRRRDRMREDARTSGVGVGRFEEWAWVETVDGDHGSVRRRKVDKTYLDLTDGENLSFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIX4</accession>
    <name>A0A2R6NIX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIX4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6857" checksum="FA32A77F23207341" modified="2018-06-20" version="1">MRFGLQQIDPMLALFAFLLLFLKHTLGRLAFLVLNPSWGHKEGSMSVLSSFGMQGELSINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ61</accession>
    <name>A0A2R6NJ61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ61"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6156" checksum="FEBE5CEF60632022" modified="2018-06-20" version="1">MDAHMDPSSLEIPDFLNGFFPQARVNWLTPDQLKANVGEDPSLDSDVTLNQDCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJD8</accession>
    <name>A0A2R6NJD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001188">
        <property type="protein sequence ID" value="PSR72421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJD8"/>
    <dbReference type="OrthoDB" id="3266934at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="153" mass="16765" checksum="5F72EF3AACFA34DF" modified="2018-06-20" version="1">MVPSLTPSLFFFIYNFADKKVLSSVSLQPVLGKEVRLSPVALMELFAMGSLSQTIVPLNPPHIPGSIFSPGLTPPIVLFPDQEHRQLSYYKTATTHSTETSSLNLHASICAERSREDLEAAGYEIPALTANASFGDMRNAHYLIPDLPPPQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK23</accession>
    <name>A0A2R6NK23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001141">
        <property type="protein sequence ID" value="PSR72676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK23"/>
    <dbReference type="STRING" id="98765.A0A2R6NK23"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF2">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="488" mass="53245" checksum="FC38D40F8F551B0D" modified="2018-06-20" version="1">MADGASAIIGVVAFGLHAVHRVYEVIYSIKDASADILALQHDAKEVGSLLLQLQQSQVLGSAVLPQNADVFVLTNRFKDALSKITSFADKVAEERRDGKVGLRKLQWLLRDGRCAKLRAGMSSLKTSIIAVVAASTSQSVNTVQATMTRLAEAQQQSCNNMDAFKQDHESWFTRQVADLASFRAIVEERLAAIAHNQDKIFNMLASSPEATRSPDNSLPTLPVTVLITPLQLLQYYASSRQLRGSDINSIRTIQLHIAGPIFHEDAIDAWEDWLEKCDFPEIYRAVLVDTSTGPDSSLKNLLASRVADIDVPCRKGFTPLEWSLFMHISSSVEVFLECGADIHKGYPLHGAASCGNTGALETLVRAGVDINQQDARGWTPLHGAAYYGVVDCVKELIRVGGEGLDWGALDHNGRIAIDEARRGLEHVEGQGKSADSHNEVIRVLLDLQTSGSSSGASESGRLNNTTYRRMEAEEDLKIPGSFSMEYIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKN1</accession>
    <name>A0A2R6NKN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKN1"/>
    <dbReference type="STRING" id="98765.A0A2R6NKN1"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12372">
        <property type="entry name" value="RRM_CFIm68_CFIm59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="111"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="391" mass="40676" checksum="8CEA3C14D0CBF0D9" modified="2018-06-20" version="1">MPEDDFDIYGEDEGFSTKPVGALDDYDDDIKEEEPEQASSTPSVGEKRPREEDEPEDQSNSNFPIKHETRGESETQSFDTAVNGSVGGMNALTNGVAGVGNAAGANTGQFDALYIGDLQWWTTDEDVRQIAAKHGVNLDHKDITFSEHKVNGKSKGIAYIECHNADNATVLKNWFDNNDFQNRRASATYTSTSQGNPFRTLPKEPPARDSRQSAGAPIPSTANGQATGRGGGSYRGGMNSPANNMGMGNNMIGGMGMRGNMLGGGMMRGGVPSMVGGMSGMGMGGMGMGMGMGTGFVGNSMGTGFGGGRGGMIPQGPRGGAMGGGFGGRGGMMNGMGGMGMMPMGGRGGFNGVQGHFNPAFMPNAMQGGMQNNGQFGSDGPRKRFKLDESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKS9</accession>
    <name>A0A2R6NKS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKS9"/>
    <dbReference type="STRING" id="98765.A0A2R6NKS9"/>
    <dbReference type="OrthoDB" id="3358904at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="9834" checksum="E717CFC63C01FA99" modified="2018-06-20" version="1">MDTANGHVSWQAGFNRLVDVLAALDARGELELETVSAASKACSECWSVAGNWRELEDANCRESVRGIAVRLKGLLDENGRTYHGGRLYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKW1</accession>
    <name>A0A2R6NKW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v11118</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKW1"/>
    <dbReference type="STRING" id="98765.A0A2R6NKW1"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000002">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="13">
        <location>
            <begin position="97"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR73014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="420" mass="45354" checksum="D8F08940CE1513E1" modified="2018-06-20" version="1">MPKAGRTPIYYAVAKGHSPGIYETWSECEAHVKGFHGAKYKKFHTIVEAEAWIASGGSSKPLSTADVGASSKQPPAASDGVTNVGGASGSNAGGTTKDGWLVVYCDGACKGNGKRSSVAGVGVWWGQGDPRNIAERCPGGQTNNRAELIAIVRVLENAPKDHIPLEIRTDSQYSIKCLGEWLPKWQRNGFKSSSGGEVKNAVLIRYIAALLNERGRLGQKVVFQHVYGHRGEVGNEGADYQANLGCLLPESEEPDWAMLEIATREEIAATQPNIAPDRDNENATVDTTVDMQEIQVDSSDSVIDDDVDTTEFVEMTPAGASKIRSTKVEQPIPPLSTRRHRKPYDRPSSSTPHPNVLQDVAVQTLPYVHPLGYVPQDPTIIPHIHPPAPTPQFTKEDLEVCLAQSSLSFQGAVESDLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKX6</accession>
    <name>A0A2R6NKX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKX6"/>
    <dbReference type="STRING" id="98765.A0A2R6NKX6"/>
    <dbReference type="OrthoDB" id="3222669at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14958" checksum="66371B03B2DC4393" modified="2018-06-20" version="1">MAALYLHQALFASDIPPQPSIVHRIGSPHEQQLSSISTGTLRTTTTDHSHPSEPLLHTPYTESSVYLDLLSRQPLHPDEAARTSWVPTLSLESDPMTPRERRRLREEVKRKRIRRLKWVKNILVGIAEPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLB6</accession>
    <name>A0A2R6NLB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001100">
        <property type="protein sequence ID" value="PSR73179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NLB6"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40591" checksum="1BCA89FECF3955A9" modified="2018-06-20" version="1">MDPASVPDPFWKLSDFTITHKSPLTSLSTLTKHLPSMAAAKRLHSEIPVLPAGEAILCAPKAIAGTFRRSNDQEASSITTLGNGYLRIRPRLLVENLPETYSPEDPLPDFSHIQPARTITLTGDLAQFIPLIKRMQRDTKVGHSNTKTLRKHFSRKDRTAYGAKTKALDSVFEAAIKMGVVIKEGTPPKSREKLLLIPRATYVFPAGGIGQATAKALAQQGCSIAVHHSSDASKSKAQDLIAELTQHEGVRAAAFQADLSTYENTKSLYDDVVKRLGHPDILFGNHGATKKTIGPTGDIGDISPELFEETWKLNTGTNFYLSPVVTYLSDFIFFSDRRGHWAPLCLVKVRYARLGALAFSAVLQGRNCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMH9</accession>
    <name>A0A2R6NMH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMH9"/>
    <dbReference type="STRING" id="98765.A0A2R6NMH9"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="723"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="958"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1227" mass="136663" checksum="09718AD17844BFAC" modified="2018-06-20" version="1">MSGTAEGEPVDSAVAALLKHNDSIAGPPAAPRKRKRKARALSPEDIGQPSATSDHVAKKKKTAETCLSKDMVVEFDAQRAQSDTQLYTRMYNMGREYISPYYFNAAQKLLLDLGPCAADLLWRLVLEGRTPADAPSKEAIPPTIRQFIETWNFDMPNPSPLSHCYNVTHKFSKLVDVLQSCETQDDSFRGLILVEQPIVASMIVEMLGALDDILLHVRPFTIPGLDPSNSPWHQRTALDSFASGTYNLLVCTQCIEHLEIPGVAVVIQFDLSDSPPSRILPHEPTEHQTLIVHMVEGNNTLHKDILDSYKRPTPREHSHLEPQAQSSTQRDQTGFIHDPTTGLRIYPSDAKAVLRRFICSLPQSARRATTTTDIHSETHHTCILGFPGILKSKVKVTRASGEEAREVVAYRACEELFTECLLDYRFFPTTRPSEDPTKADNSAVGKEEPGTSRSANASLTTRCYSKKSALFWSNSLSVLGPHLYSMILCVERFKDEYHAPILVLTRLPLPDLSEFSVFSSGSRAQVHFHRGSAIPVDEEKLAILHGYTLRIFRAVVNKVIDSSMSNMPYFFAPLKADWDCNKAKTGARQVDIGHKIQWEEMKIASLQWCTSLVDEDRPLTDEMVHDAIVQDRFVEFTNRHYVVRARHDLSPLSKAEDGEREAGHANFLEYCKSRRKDFEGLNNENQPLIEVSLVPPAVNALSPTSKPAAAHTKYPAKSTFFDNIVEENHLLAAVSPPTASVEHDYERLEFLGDAFLKYAVSTYLFVTMPSDREGSLHQARQRIISNKALHLGALQAGIPPYIQSKPVVAKIWHPAGYSRTNDGKSTAGGAAVEIKAEDDGDVVSTLQSSASMDVDTDVGRFPTPQDNEESKLRPRHFGGKRKKQQEEQSLQWLGDKTVADVVEAIIGAAFLTKERDAALSITKILRVPLPGVEQWPDFARSEALSAGEDFQRIPSHVCKTVQKIVGYKFQRPLLLAEALVHSSLPGHKSKNYDRLEFLGDAVLDFPMVSNATLATICVSMGLYKHAQHASLDLTNSIAAYMEQVRVLQDREYKLAAGENRQPGQFWLEIEPPKVLSDVVESIIGAIYVDDSYKNNGVQKFFDEHLKPFYDHHIRLQTLSDHPNKTLTEIFHAESCQNHSIVKEMVGTTLRCDVLVHDVVLASGTDTLSNAALRKAAMGALDALANDPSFMTRVCDCRTSRADKGGRKKQQHANNAHGEQDFEMTQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMQ6</accession>
    <name>A0A2R6NMQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMQ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NMQ6"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="181" mass="18703" checksum="A9FBCC3CD33BE5BB" modified="2018-06-20" version="1">MSQSHLPPSETSPLLRSTAHSIISYDGEDDLTSPSSPVDFTPFNKVSKTDLAWVLAGLWSAVFLGALDGTIVATLLAPIGSYFNESNRSSYIGTSYLLSVCCFTPLYGRLSDILGRKGAMLLALSLFGVGTLLCGLAPSMDSLIAARAIAGMGGGGLFGLGAGLGGPLGGWMNDSFGWCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMY3</accession>
    <name>A0A2R6NMY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v10432</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMY3"/>
    <dbReference type="STRING" id="98765.A0A2R6NMY3"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="403" mass="43734" checksum="F66E108510D1C1CE" modified="2018-06-20" version="1">MAIQSSLGTETIAASSTNETIDVQKDLAMLDASKLRINLADRLKPVPTPENVVFGKHMSDHMLVATYDPSSGWSEPEIKPYGPLLLDPTSSCFHYSTSLFEGMKAYSGPDGESRLFRPELNMARMVRSAERVALPPFDPNELLKLIKRLVQIESRWIPQESGYSLYIRPTIIGTRPYIGMGASDYATLFVVCCPAGLYFRRGAKMLSLMTLGAHVRAWPGGTGGHKISANYAATFLPQQVAAERGYDQVLWLLGDRITEAGAMNFFVVRKRSDGDLDLITAPLDGTVLPGVTRDSVLSLAGAHGHGITLPNLPPSLKIHVQECTFTTSDLSQWAEDGTLIEAFSAGTAVVIVSIGRIGLEGETDIILPKQESGMGPVAEAMCGMITAIQEGREQWSGWSVLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN05</accession>
    <name>A0A2R6NN05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN05"/>
    <dbReference type="STRING" id="98765.A0A2R6NN05"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="20905" checksum="14B57D16E4427DE7" modified="2018-06-20" version="1">MEKNTKKPQADAIAWDTDGLWTEHLRRDDQDMMDRIVNGSEKGHYFMLLGPKGTGKTTMLFDAMRAIHAEGASICDAHPDLEVFRLRLGKALNYEYHEDSQTGLFQRRDPREGGPALDIERALNKLEKVALRYSARTNRPLVLILNNIHFFKNDDEGQNMLLQLQQRAEAWAASGAGYIYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQF6</accession>
    <name>A0A2R6NQF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQF6"/>
    <dbReference type="OrthoDB" id="3256943at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="223" mass="24482" checksum="425E9B4EF10B1837" modified="2018-06-20" version="1">MSSSSSSPLAATSTTSNDASQSTSPSTGNGTSPPSSTLYLLTFLATLFVLLFVSCAIVLRSFFLRRRLQRLYEEQIAAGLLPSDARYPGRRGFGEQPKLWDLGLEPLPHEEWAAWDHISPLAAKHITHASSYDNNFESLPRSTTPARRGPFSHLLVRHRPPTEPPSSDDHPKSETYTRPSCDINADIHVAVFITMPARRSLQGEGIPDMVIGVSQVPMQTDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQX8</accession>
    <name>A0A2R6NQX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQX8"/>
    <dbReference type="STRING" id="98765.A0A2R6NQX8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="291" mass="32025" checksum="36B509A037B5D9AA" modified="2018-06-20" version="1">MPPLLISHVHQASLQGIVEASFFPGALFLISKWYKHDELGLRTAILFCGNIISNAFGALIASAILDNMQGVLGRAAWRWLFYVEGSLTVLVAVCAMFVLPDFPETTSPGWLSAKEISLAIKRMEEDTDLVHGREAESLSSGFWMAIQDRNVWLLTCTMACQIVTVSFTAYFPTLTATLGYSRTISLLLCAPPYLISAVLAFFWSRHSDKTRERFYHISIPLCVGIFGFLIAACTMNTAARYVSMFLTVQSYAGVCVLYGWLSNTFPSPPAKRAVALAFINSFSQVGNITGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR99</accession>
    <name>A0A2R6NR99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR99"/>
    <dbReference type="STRING" id="98765.A0A2R6NR99"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="10757" checksum="40847840B07BA683" modified="2018-06-20" version="1">MVEYLKNGTLLTLPEVGDVLGTVNAVTMGNYEQPIKISVFVKDLFAGFAMLNLKNDTLRRRYDSLKYDIKKIEEGIVYDVSLRNLAPASSNTEQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRD4</accession>
    <name>A0A2R6NRD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000909">
        <property type="protein sequence ID" value="PSR75279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRD4"/>
    <dbReference type="STRING" id="98765.A0A2R6NRD4"/>
    <dbReference type="OrthoDB" id="3269417at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="339" mass="38269" checksum="ED0F51A681FC02D4" modified="2018-06-20" version="1">MGAYHRILEQATTNLGKATRQFAAACANIDTRELPKEEAARGRREAVMGKTVAIGKKQKRLNLATFKYHDLGHVVPTIRCCGTTKSYSTQVGESEHKRVKKFYARTNKSRHEGQITAKEHREGLLFGIKEQDEVAKKAAAETNLGRQAPDQPKKRGRPCKDQFGLLPNKEEHLPQTSYHSHHHISDSQRSGFKITTWLAQHSDDPGLKIEQVCGQRYVHALPCIGHKAARHIVKIADSLQAFFENGSGIAARTEDAEEEIDFKDRTDVLLAVDTDLDERASEDIEGEDKDEDNKDEEEEGEEEEEDEESDSEVDEEEETDGEDSEGDERREEETDSERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRK6</accession>
    <name>A0A2R6NRK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v9170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000905">
        <property type="protein sequence ID" value="PSR75361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRK6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRK6"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015321620" description="tripeptidyl-peptidase II" evidence="12">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="13">
        <location>
            <begin position="209"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR75361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="585" mass="60561" checksum="116D6CFE13997CAA" modified="2018-06-20" version="1">MFKSKLLIAACLVSFALAKPHARDMTVRESRESIPAGYVHSGAADADTTINLRIALVQNNPSGLIDALYDVSTPSSPSYGEHLSKEEVETFVAPTAQTVESVNSWLNEAGLSATAITPAGDWLSVSLPVSKANELFDADFSVFTHSETGKQAIRTMSYSIPTRLEGQLDFIHPAISFPSPFSKLPVVSSPNGQIAAITGPLASTCSSSAITPACVQSLYGIPTTLATQSSNQLGVSGFIDQFANQADLTSFLKKFRTDLKSSTTFNLQTLDGGSNSQSGSQAGVEANLDTQYTVGLASGVPTTFISVGENTQDGDLGGFLDIINFLLGESAPPQVLTTSYGENENEISRSLANNLCNAYAQLGARGTSILFASGDGGVSGSQSGSCSKFVATFPSGCPFMTSVGATQLSGSSSETAASFSSGGFSNYFGTPSYQSSAVSSYLSSIGSTNSGKFNTSGRAYPDVSAMGTNVEIVVDGQSETVDGTSCASPIFASVVALLNDQLIAAGKSPLGFLNPFLYANPSAFNDITSGELYFFSRALIVDADIDPKGDNPGCSTNGFKAAKGWDPVTGLGTPKFSALKAAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRP1</accession>
    <name>A0A2R6NRP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000902">
        <property type="protein sequence ID" value="PSR75420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRP1"/>
    <dbReference type="STRING" id="98765.A0A2R6NRP1"/>
    <dbReference type="OrthoDB" id="2756205at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="17364" checksum="E8375C767B8E8ED2" modified="2018-06-20" version="1" fragment="single">CTAFTFLRVDYESVVSWKTVTDLPRCNPMFHGVPRYDGIIVNVAGDVKLFAKLIFLFCYSFGENQYPLALIQMLDQPLDRNRDIQVDVDLDFYRVRAKPRRSCEFIPIRSIVRGALLYDDPGNAGESLVVDTIDTDMFLRLKELSMERGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRQ0</accession>
    <name>A0A2R6NRQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRQ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NRQ0"/>
    <dbReference type="OrthoDB" id="5593376at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1097" mass="117248" checksum="DCDC3C34F74D96E9" modified="2018-06-20" version="1">MSLGMHMTAVDLSPMDVVPAPLPERTYANGMLSDFSGQAGSSFQQQDPQMNGIEASHQLLSSPSATTASTSVSHASSPSMNGMVPAYAIASSSLASALDSSRSRSGSSASPGHLAGPSPDLGFPSSSSIQSNTSIHDPAYPFPYENSYSSTPQSKENSPDGDGQQRQFLGTVLKQIAAAANSGSEAVSNGQTTETLSIVDSLKKTLTWVSDMLKDLDINEQHHSGPSTNGSPHAHPAAGVTASHHHSPQSSTGFEPSQLQHINGVTSYSQQTTNTSLEQGLLDPSDMSRKRCASTAAGDRIVKAMKMEPPDDVSLQMLPIHPPQPPHMNTSPVFPYSTSNSIPPLMSTIAEHAPIPSLPSSVPVSRPASSSGLPPHHPLNLMADIQQSQQSLSFPSRMDFNPQLSHSPSDFPTLSSSSMASQMNAFSPTTSLSNATWSDNRPTISRHSHSLSGSSVLASMPHNGLPMAISTNLQYSPTTGQFSSPTHSVHPSQPPLPTGNVPPSIGRMSRSSSISQANPFAYGIDMQPLPQVVPIKAYEPMQSRPSTSGLHTRPQSPEYDDDDDGDESDDEHHLSYLTYPTPPSGASPDDGKGENGMPNAPSGTSARRGSRTSPSAESNAGHGNEVPQEYKADVERIFFEFLNKTCSNLDATDSKGEPIHQTLMAKKMQRLDESPDFRPFKFRIQAFTNAFLEELARQGFPEEKIPMKKIRNFLWNQPFISRFNEEGKKSKSKGNHIWHVDAKKTDGGWMFRPFQRKLAGAPPGVAYIGLRWSWTPRIWDPQASRSNMPVTYNSPSLPSWLSWSNDTLSGIPPPDAENCDVTVEAQFIQDGKEESLSHTVHLNIAPMAAVDASFTPSRRPSLVGDLNNPRRVMSDSVLSQTTPPRALRGQTMSQGGPVAPDSQVVQVLTTAAQRVAQEAQSQVVGSPNDLTLDLNSLAKQQHVLTVTAQAFNNKSGDPQDESSTAQSNALTAAAQQVVLQAARQVAADRTVAAVSSGIPNPVVLTSQVTVKEVSVATQSAVAQAVEMIGPLSSEVDVLMTAKSLIQQQMRSPLDPGQLPGSLDQVRPHSTGGTMLSFSSQSSIVAPPPVPAFFQHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRR8</accession>
    <name>A0A2R6NRR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000884">
        <property type="protein sequence ID" value="PSR75526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRR8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="16318" checksum="0C5FEFE335138270" modified="2018-06-20" version="1">MPFSKTRPLRGYWFPHTVSNPRYINSDNTRYYLNAGFDVPDLRTFFPNCDNVLSHTVTIDTISGCEVRPVRYIVFFKHCTPQTLSSTNPSLAKLHPALQLTGSVVVFRCSKVEGRRKLVNMHSNDNVYARHAVHKMLQEFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRV5</accession>
    <name>A0A2R6NRV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000931">
        <property type="protein sequence ID" value="PSR75095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NRV5"/>
    <dbReference type="OrthoDB" id="2986975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="152" mass="16937" checksum="ECC5FA60512B7E0D" modified="2018-06-20" version="1">MERHAGALMERHKASLVTPRHAVRGLWNKNGAWKWCAGSGNQLFVCPAEDQVFNGGNSYTELNLQERYAVACHSNVESSHQKKDLPRIVELAKGMIVLVTQNLETDLDLTNGACGVIINIILHKDEPPRPEIGLVHLKYLPALYMGIKVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS61</accession>
    <name>A0A2R6NS61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS61"/>
    <dbReference type="STRING" id="98765.A0A2R6NS61"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="353" mass="39553" checksum="E3337F164E0F460E" modified="2018-06-20" version="1">MDERRAKTLEALSTFIDSQRTLLTRTQANIVRLTQLRNDIAQNEHDECSVTAYGSQLDGTGYGEPEEQSRVLPAIPKEINWSLYASADSPDPAPLTALATSARIAYTAQRKPSLKQSTPLSDLQQLVKDSRVTMLDPILASLPPLSSDEDEEPPDPEELRRIREREKIRELKRRRIHGDSGFIYGLSGLGLRKPGAEAVFVRRDQEDETAEVDIGLGDQINTNSSEQPNLVFPNAPTKVKKEEHTSSIPHYEETELLDDVPSATKGSRARRPTRKATDSRTQCVKTSSTKKTSTQQTEAPDATKEEDIPKTDKKGKLRPETYKQAWSVSEQHLLERLLEEIPDGEKNRSVCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS87</accession>
    <name>A0A2R6NS87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Timeless N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS87"/>
    <dbReference type="STRING" id="98765.A0A2R6NS87"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="6">
        <location>
            <begin position="42"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="942"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1027"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1178" mass="133712" checksum="98FF4461761FD0E4" modified="2018-06-20" version="1">MNRDDAISVESGDEDSGNVRRAILETPIRNVVEALGGYEEGRYRLGDECYGCLKDLKKFWRKDDTDDERTVARLFWETRVLPNDLVPILLETAGKGMFEDKRAIACADLMTAMTWPIDMAEELLELDEVLDKGTDYTQLIQSHLHYKAALLKPGVMEALFAIILPCLAKDVKERTERDIQIIGVVLYLVRNLAFIKDPPANMHTSADQAEYSSLQSRLIKVLSGTHILDLLLTLASNAGTDTMFNGWNTLVLEIFNLLFRGVKPSSLSADQSKEPTQNLKRLLAVEDKRKRDIARNASSRHSRFGTTISVTLNPKKSQNGGAENGAVVEIQAPEASSSSQAFVLHRQQAINREAGSILDMTSSKRTKAQKTKKVDEFARDENLSLESKFILQNLAKSFIESCFNRAYTHLSNLEMRLTRCVYHVLAFLASLLKDIKAERPKITEKDNLRLLYIMKWFLEFFLCQRVSDKEQSWSFGLVAEVAERNWIGWVLKRMRQAMEEKPKSWTELQAGVECLTQLVLLIDGMCSSGDPSVADVAEVLQTQIIYNGEVLDNAFESLRVYKEGTQSLAYLDSSVYLAYALLRLLERSSKKERGAYVRKKAKRKSKGKRSNDDSGVPEHEDESEEEEKITETMFTFDAFEQRFAHPDVTQTLMLYLARYKEFHSPENMKRIVNLLHRQAVKAKAEGLFFKVSTLDLFKNILSEEKSLPKEQAYKDLVNLINYILRKFFKAVEEDSFLMVEAFFPKNRGKWKQLSSWEPPEKNTGPQAYADESLPGSQWPAEVKIKKGFTWSQEMGIAIACLVDNGKMTLIDWIKQILIMVIGQRQRIIEDTDGSSSQQIDLISDDEDEAARALKLREASREAIAKFTDYMIPYVSDEQADAATKDPHVKLMFRLLNFALLQEDAEELEWYVPQAIVPSELQRSLNIINQFLEEPIDLGGKKAAQMLHKKRRTRRRRRAETVDSEEEHASDDELTRKRKEKKQKEHKQYKSAQFIEDSDIEDDALDAFFAREKELREKMALASVVSGKVATMKATGTKKRRNRNEDKGSKKRKRGVDGGSDKGENEDGAQPAIDSDTDSEEAIFNPFASPKQVPSTARTSPESGEEKRAKPKPRPRPRLRAQRTSSPNKTNSPQPEVEPSTSGSRDTSPLNISSDDDNIAGSKLAGKKRKPMVIPDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSB3</accession>
    <name>A0A2R6NSB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSB3"/>
    <dbReference type="STRING" id="98765.A0A2R6NSB3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="2"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121472" checksum="5746850A9A3115FB" modified="2018-06-20" version="1">MAKTLRDVDEEKIEDTKEDIDTLLVFAGLFAAVLTPFLAETYQTLSEDPGDTSVAIQRHMSAQSSSYVMMNGFLNSTVPAYPSDAPSFVPPPFALSINVLWFASLTLAVVTASFGILVKQWLREYMVIETSRGAKARLRVRQFRVTALDDWKVFDIAAILPLLLQFSLGLFFVGLCFFSWSVHPTIGRTVTSIVSCWGSFFFFAIIAPACSARCPYKTALLKKAMRVLRRCICGYYITRHIYLGPVKESGAAVEDEDAAGDAKGDVQILTAADAILLDDDLLVTTMSDSLEDIQSSIGQVEVIDFVIAALQQRLPASGLIARPIEFLDLSRLPERTRSTLVKITSQTVKRGLDLRSKPVNDLEEWAQDAIMILLTSYSPTFPPYVVEALTLCMTTAFAPTCHFIRDKQLAFTMMSDASSAVPMEIIYTVVVAALQQTQYLPASGPITRPIVSLDLSHLPEREWTALVKLVSQTLKCRPVLRINSSGDFEGWAQDAITILSAFYPSTFIPEAGDALTLCMTTALIPTCQLIGSAQNLLIGHTSRDSDRSEGIDPRQWLSHMLELLRGLFSRSDITLPVKDILQSIFGLVLAIPDLCGNSCAHDQDQHDLKELLSSHADHVPNSTIGGILVEYRSRLSTSEREADPQYIDPVIAADAALDNDTFLRDVLQEAVQRYQAMPSELMKFIIRIIRNRQKQSILSGHLQFDDISQTTIMGVIARLLNATLDTPRYSDASYTDWELWMKDAVLVLLSISEHLITEEICRTLVRWCTGTSSTEDWQSVIHHLLSLSGGLQITEYEGYRGVFERVHSASSPPMLFRMEETTSGAVNYIQSSVCNGACVHGSGLGEMYIAHEDQGLVFSRVADFLMASATAVKTCLGETSLSGLDDLLVAIFSADPSREIKKQQVHIAISASSCAMADTHVLDSTYVDAIGRYRLLDTIDDVFGQRSQQFFDEDFPMVAVFNVAFLHLHLMCLQISANIDLAERDTRMWSRSLSNLIDELKNFQTLRIPLEQDNDSIVAAAGKCLELLGSHPDRSAIETFIDNLNLHSRWHESKPELRDLLHGLKAFVPEDKVSQYPILDALPEEEHIQNFIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NST7</accession>
    <name>A0A2R6NST7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v8933</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NST7"/>
    <dbReference type="STRING" id="98765.A0A2R6NST7"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015308082" description="Wax synthase domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR75642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="19698" checksum="FB1262C7F007075F" modified="2018-06-20" version="1">MMYHLATLIAFALPGLDQQPSDWPPLSQAPWLSTSLAEFWSKRWHQSFRRSFVQLGGKPLRFLFGRIGGIIGVFLLSGILHDWCIWGMGRGTDFPEIGGFFLLNGVGVILEQVWEQATGRKVEGWLGWLWTMCWMTSTGNLLVDALLRRGLAGGVLVPATMRPGKVLLQVVSKCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSZ9</accession>
    <name>A0A2R6NSZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZC3H15/TMA46 family C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSZ9"/>
    <dbReference type="STRING" id="98765.A0A2R6NSZ9"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZC3H15/TMA46 family C-terminal" evidence="2">
        <location>
            <begin position="44"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="17201" checksum="94DBBC47CE1A9287" modified="2018-06-20" version="1">MAMTFTLVSHLREKLSTLVHARYEHHKQEEAEKERLVVEAEEAKTRGTPVTPESFLKWKAKFDKELAVKKAREDEEKMKGMTPKEREEYKKLATRLSGRQLFERNKDLDAADDLLEEGTVSVDISQYEREAIEEEEEEDHVTFSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTN1</accession>
    <name>A0A2R6NTN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-aminobutyrate aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTN1"/>
    <dbReference type="STRING" id="98765.A0A2R6NTN1"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR76487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="48527" checksum="B9EEE114FD9C0C30" modified="2018-06-20" version="1">MSSTIQNNTSLLEFGKKHVTAGLARSVDGVMTKGAGSYVEFGDGKVFLDFTTGIGVTGLGHCHPKVSGAAAKQCMELVHGQCSIAFTEPYLQLIERLLPMMPDPSLDSFFFWNSGSEAIEAAMKMARLFTGKQNIIAMQGAYHGRTFGAMAVTKSKTIYSEGFHPLMPGVFSIPYPYWHQLSLPPTTEQSEITAQCLNQLHLVLSQQTAPRDTAAILIEPLLGEGGYVPAPAEFLKGVREICDKEGILLIIDEVQSGFARTGKNFSIEHAGVRPDIMTIAKGLANGFPLSGVVSRKELTDKLKPGSMGGTYAGNAVACAAAVAVADVLKEEKILENVNARSKELFAGLNELRSKPSVSPVILDVRGQGLMVAVEFASPTGTSPYDSFVKPSAPARLSSRIAKRCQEKGLLILTTSVYEVIRFIPPLNITQEDLNKGIKIFSEAVEEVVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTR7</accession>
    <name>A0A2R6NTR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTR7"/>
    <dbReference type="STRING" id="98765.A0A2R6NTR7"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="323" mass="36427" checksum="ADBF776C41D73D53" modified="2018-06-20" version="1">MPGLTKLPPFPEDVPTHPLLIIDYQLIKQGDSEEIDRLWEAATKLGFCLKNHGVDAEVDNMFEAGAETMRLPLEEKMQYTQGEGEFFFGYEAKGSSAIDDSGTPDTTEYLNISKDDALAWPEKVHREYPSTVNARMESTIKPFTQKSVEINNTLLDVLNDKLGFPKETLASKHPMWEPSSCESRCIKSHPGIGGVEGRKTTLGAHTDFVSLTFLHNRLGGLQVLPPGSTNWYYVKALSSTPPKDQANYERWSLAFFTRPANNVVLRALKEDSPMVAEAVASDPGKFETGQSAYEWFHRRTKYRMIKYRTVRNKLLSPRFVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU21</accession>
    <name>A0A2R6NU21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU21"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11638" checksum="E3FE4B5A13506B06" modified="2018-06-20" version="1">MPGKVFVVGSPDSAEVADEAYCSGYQYAGSQGVAVRSQKSVVRHPKPTVRRFGRGSRRWQEGYQELVKACYQGHQVLLAEFRRRMTRKYPVLSQVAIGFPTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUF7</accession>
    <name>A0A2R6NUF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUF7"/>
    <dbReference type="STRING" id="98765.A0A2R6NUF7"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="181" mass="20200" checksum="1E83D1AFF0FC2224" modified="2018-06-20" version="1">MQTPRSSAFKVLQLAVLMYLTAALLYTTSYFIVSPVSTAIQALFRVHDVKLGDVFSYAHSVSRVDLVDRAIQAAEEAYQHPADTHSQDISLMSLLSSDDLLYWVQSKNGDNADLALTSSVPLREETFLSKAFSLAMHPTKIIPFYYKASGPISEDDVTITTLVTSNRFKVLKQLVERYQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWA7</accession>
    <name>A0A2R6NWA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v7522</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWA7"/>
    <dbReference type="STRING" id="98765.A0A2R6NWA7"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015340822" description="glucan 1,4-alpha-glucosidase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="13">
        <location>
            <begin position="32"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR78190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="486" mass="51891" checksum="9D61F22ABB66FF72" modified="2018-06-20" version="1">MRSCILLSLGLLGSALAQTTSVDTYVATESPIAKAGLLANIGPNGSKSSGAKAGVVIASPSTSNPNYLYTWVRDSSLVFKVLVDQYTAGTDTSLRGLIDDFVTAEATLQQVTNPSGSVDTGGLGEPKFNIDETAFTDPWGRPQRDGPALRSIAIVTYANWLLDNGNTTFVSQTLWPIIQLDLNYVANFWNQSTFDLWEEVDSSSFWTTAVQHRSLREGSSLATRIGQTSSVAFYKAQADNLLCFLQTYWNPSGHYITANTGGGRSGIDSNTVLASIHTFDPAAGCDASTFQPCSDKALSNLKVYVDSFRSIYPINNGIASNGAVATGRYPEDVYQGGNPWYLSTMAVAEQLYDALYVWDTQDSLTVTSISLPFFQLFDSAIQSGTYPSSSSAFTTLTSAIRTFADGFIAIHAKYTPSGGALAEQFTKSNGAPTSAVDLTWSYAAALTGFAARSATNVASWGAAGLTVPALSNMEQYVNYLIGLVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWD9</accession>
    <name>A0A2R6NWD9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ty3 transposon capsid-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000754">
        <property type="protein sequence ID" value="PSR78233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWD9"/>
    <dbReference type="STRING" id="98765.A0A2R6NWD9"/>
    <dbReference type="OrthoDB" id="2768905at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ty3 transposon capsid-like protein" evidence="2">
        <location>
            <begin position="57"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="296" mass="33321" checksum="A43E49215576615A" modified="2018-06-20" version="1">MASHYDNAIGSLAQQVTTFLMTVQTQQALVVSYKRQVDALPALAGSGHSCQPKIGEPPSFRGSDNKTKLDEWLNLIVLWCEHEGVATDKQRIVTALSKLQEPAHQYMMSYYVRMCKGKDLGTWKGFVNELAQIYGQRDDKEGAKKEITALFTNKDLTFKDFVKYAERFRTLGQLTGYNNGLLIDKLREVLPCDMRLVLAGKVESALPTEWTKFLDVLLNINKVVNPEKSRGTFFSKGGSDDHQTPMDIDLAKKSKGKGKNKDKQVATATADKKKFCHICKKTLHNTDDCYQLAKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWY1</accession>
    <name>A0A2R6NWY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000726">
        <property type="protein sequence ID" value="PSR78751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWY1"/>
    <dbReference type="STRING" id="98765.A0A2R6NWY1"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="3">
        <location>
            <begin position="479"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="562" mass="61376" checksum="E3C0E74890C83535" modified="2018-06-20" version="1">MENLIAIGVGLGLRALLDAVAHDSYRASALVGIWEGVVLNHFLAKFPSSVDPYIAFAFRLFVDYLFTESLSRIIIIVLWTGLGGLLADVAVQLSGDRRFRRLWRRTVSSLPWSGSHSRPTSSRVRFYEVPDSSSTAGSATPTVASIPVRPTTHPVPGQFDGWSEVTPSTVSAPSEHPSEVGLDPEQSPQMTPQPRTPSELEYISLPVIPDMRDSTSLYDLSARPTSLPPYIADLNDNENNEPLLNAGDDAPVIHSGLTTPTNDPMSLSRPFDDEDRPLIHSGLTTPEHMHTAGLPPIAIFDDGEFGSSIKNLPDQDPVPIRLTIAPPSPLAASIAFPEPQLTPMLLPPTSEIPNIPSPDDPDVNPTADDDKRTPPPSFDEAMKAEDLESEAAAESVVSGGRNTIIDKADEMRNRAIQLEASRDKIKNEMKRARAEKRYADALSLAVEYDETHEEISLLHAKAARRYYRAHNLNQPPQEIDVHRLSVSEANIQVKKAFRDAYRMGAPQLRIITGRGKHSKGGIPVLKLAIVGEMQKNHIEAQPDEKNPGVLIINLPNAPSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX10</accession>
    <name>A0A2R6NX10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">PHLCEN_2v7380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX10"/>
    <dbReference type="STRING" id="98765.A0A2R6NX10"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR78633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="371" mass="40685" checksum="1969B867C0E67372" modified="2018-06-20" version="1">MNVDLPGKFELVAELEGHDDRAWHIAWNPTRNLLASCSADKTVRLYNFSSSTNQSDGTTNGLTFTHNTTIPTGHTKTVRAVAWSPSGKTLATASFDANIGIWAQEEDNEEAEDSPSGEWECMSLLEGHETECKSIAYSSTGTLLASCSRDKTVWIWEVHPDSDFECMGVLMEHTQDVKCVAWHPTEEILASASYDDTIKLYLDDPSDDWFCATTLTGHGSTVWTLAWEPLQGGYLASGSDDGTIRIWRRLPVKGELRFDCVAVLEGHDRSVYSISWSPSPPSVVVEGEQQCELGLLASTGGDGIVLIWQITETTEADSGKTVIEHKIVARIDAAHGVFDVNSIAWCPRTGLQDVLATTGDDGHVKVWKIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYG8</accession>
    <name>A0A2R6NYG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000665">
        <property type="protein sequence ID" value="PSR80167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYG8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7288" checksum="3E322C72F0923C56" modified="2018-06-20" version="1" fragment="single">MRWWLLGLNAEIHVDLLRIGWLCHDPWVPHAALWDTISPRVLGPSLKHLEIETSGPVAIWEGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYS6</accession>
    <name>A0A2R6NYS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYS6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7463" checksum="123AB2157E5AFEA0" modified="2018-06-20" version="1">MVKAIKREATQVKAIFLTGSVSQGAPRQSSATHLLLPNIRNQTPRDRATTPPPPLIRAGHPMIVAKPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYY3</accession>
    <name>A0A2R6NYY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYY3"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="89"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="35189" checksum="EFC846C6C33E9BE5" modified="2018-06-20" version="1">MVNARGYLFISLNAVRFLSIVGLILLFSSSIVAMVHDVKAVNAFIADGKSDASSATSNLTSTDNSFDCSVYDCDYIEGSTVPNQPAGAFWAVLNRLLIIFQCVILILSECSWPSQFFSSYFPVLGPSFGLGALGVIQCLLGAAVLSHHVDEFSLVSAFFVFSIGCLNILLGLIFRESVKHKRSIREWKEKEPGTLPTVRDGKVPRFDVSRNVFLDRPVSDEKGAFGAYRSGSLSSQKVGFGFGRQGEKMAANQGYVVREPEESVPPYAAKPISHSKHSSRDSRDSRSSYSESRRQSSHHEEDDEEEDGSPAMTRTNSSATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYZ6</accession>
    <name>A0A2R6NYZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000638">
        <property type="protein sequence ID" value="PSR80830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYZ6"/>
    <dbReference type="OrthoDB" id="3239894at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1212" mass="136201" checksum="D055E64AF9D54C10" modified="2018-06-20" version="1" fragment="single">SYTESRHTTMEYNDKRTKYEYEKQLAPCDCEDCEGAMVPIYTVKSHRKRKRFKLQPALDTSSDEDPSTKVRQSSKHSETQKRRKTTTSTHRRPVDVQVPEVKSAPGPLAPNTVSTTTPICSTTPTLPYAFLSDISTISATLIHTPTPSFLPQSIGTLPDNPGPHELYTVATMPNTSPDLPCANTINDIAQDTTLDPHTHRADSPFLDYFDPPPLPLHLPHVSNDPPPSPPLPQSTAHATQPDHPQDLHASSGPENNHDDLHATFGPDLNGDLHAIFGPDLPLASSPSPSATVTHATQPDHPQDLHASSGPENNHDDLHAIFGPDLPLASSPSPSATVTQAPRQEIVFERTPFAPEVVETSTTTWFWRPLMMLAAWLHLQHGLSHKGVGLFLNIIKITLIAIGVLTRKDDSPTDLRTAFTRLNLHDKFSVAPTCPTCRRVFPSDSPDDLQCNICNISLFSGEKYSSFGIPIHDDAIGTTWKRKTGNKKSRKPILQSPIRLPSHLIAEIINSTETMEHDLDKWRGIPLEHGVLKSIQDGNVWKTIPGPILDGPVFFDNTPDRPNPEELRIGVTLGFDGYRPQNLLLCGLTPGPREPNADELQYFMKLFVDDLLDLYDHGIIVKTAQYPQDHGSKSFFCPKGNMQHTDLGTLAGVTIDACNPRDEKEHRRLAEEYSKLMTKGDRDAFCRNHGVRNSELLRLPYFNPIQMTIIDPMHNILLGVMKTQWYEVWIKEGALRERTQVRPRELDTVHEYLKLFEMPSWVARMPRDVGYPAGGSLTSDEWKALLLIYCPVVIPMVWEEWIQAAEKEYKTKLKNWKKKMQNYLASANRSDNPPPKPKRRMYPKDDDNFLCLAASMKILLARTINIEELPRAQTLLQDYLDGFHEILDYGPVYGFWTYLFERLNKILKSYSVNNHDGGELEVTFYREFSREVRLRSMLSVMSTTAVNINTSKAEQLVLDASQLMIKTDADDRGTMAALMQEIDGISAEMATKFSVSPGVLSALKFDQQQFFVKYYNDVYPDCAIVSRADPHASAESIFLNNQVTLHDHLVLNGRRIVPSSFNGYAPNSIIQYSAVGQTYVGEVLFIATHRQPLSNHPALVQCLLGVRWLSRLTRQDFDTAAWDPYPELEVMAWRHNTYLNPAVEGPSFLIPAANILSQACRLTLSVHEARTEEVGSDNDGNLQEQPRMRHQGLRTTVSKVWLTAGLTRDVQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0J9</accession>
    <name>A0A2R6P0J9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v6003</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0J9"/>
    <dbReference type="STRING" id="98765.A0A2R6P0J9"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="180"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR82570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="424" mass="47232" checksum="DBF46F08C0AE2604" modified="2018-06-20" version="1">MSESKGRVLLAYSGGLDTSCILAWLIEEGYEVYAFMADVGQEEDFEAARVKALKVGAKKFFLEDLKREFVTELIYPAVQANCIYENVYLLGTSLARPVIARGMMAIADREGCDFVSHGCTGKGNDQVRFELAFYGLKPDIKVIAPWRIPAFYHRFAGRQALLAFAAEKNIPVQQTAAKPWSTDENLFHISYEAGILEDPNITPPTDMWKLTTAPEDAPNTPERISIEFKAGLPVKVTAGDKTYTDPVDVFLALNALARKHGIGRIDIVENRFIGVKSRGCYESPAATILRVAHMDIEGLTLDRNVRALRDQFVTVELSKILYNGHWFTPEREFVVSSIPASQRTVNGVVRLKLYKGNVVVEGRFSDEGLYDAKESSMDELGGFEPTDTTGFIQIESIRIKKWAQANIQKGQTGIEPKDVYGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0R6</accession>
    <name>A0A2R6P0R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000578">
        <property type="protein sequence ID" value="PSR82694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0R6"/>
    <dbReference type="STRING" id="98765.A0A2R6P0R6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="163" mass="17617" checksum="486FFD28EE95ADE1" modified="2018-06-20" version="1">MARASYDPKIGSYAFASKLATQPILDLSNVKASSEILSVESIAGVGVDQDKNALLSGVGKGSVGVEILKGLLPSGAHIVVTISRYSRATSTTHASFSVSAAEAPPLLWFLSIRIKTRRKGACRLHLCHPRLGRRPYSPFATFSLRYILPSLHSPFATFSLRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P143</accession>
    <name>A0A2R6P143_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P143"/>
    <dbReference type="STRING" id="98765.A0A2R6P143"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="10108" checksum="1BC7453A21CC091B" modified="2018-06-20" version="1">MSIIFYGALVSPTSLTSYLALPHAVISVTRKTGTIEWIEEDVPASQLQDILAMHGHPNITKLHGWIQFIQLKTGEFLMPGFIDTHTVSELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1B5</accession>
    <name>A0A2R6P1B5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000579">
        <property type="protein sequence ID" value="PSR82659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1B5"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR82659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="218" mass="24047" checksum="BDDFF3D4C1A4740E" modified="2018-06-20" version="1">MPIVDGMEACPSPSKDDPKTKKITSWNTRDRKAKAQITLMLRDKPLNGVMYAKTSKEVWDRLKDRYEGKGKQTIAYLITELFRGTLYDKSPLGPQMDATVQKGHVITSLGQTLDDSLIAMILMLSDHTLTMEKITTAVPCQKKDRNHSLDMTALVARNGNRSGNKGKGFGGHGKGNNNKKKHIKCDFCGKRGHVKDECCKLKAAQSGEQPKALTAKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1U5</accession>
    <name>A0A2R6P1U5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000551">
        <property type="protein sequence ID" value="PSR83795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1U5"/>
    <dbReference type="STRING" id="98765.A0A2R6P1U5"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR83795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="258" mass="27669" checksum="30FD63356C6E53CA" modified="2018-06-20" version="1">MGPYQGGQAEFVRVPFADFNALKLPPGKEHEEDFALLSDIFPTGWHGVELSGFRPGESIAVFGAGPVGLMAAYSAVLRGAAQTYVVDRVPERLQKAKEIGCIPIDLTQGDPAEQIKKLRGGKEVDRGVDAVGYQAVAADGKTEQPNAVLEGLISVVRPTGGLGIPGLYVPKDPGAPDSNSAKGYITFPFGKLFEKGLTVGTGQCNVKKYNRYLRDLIIAGRAKPSFVVSHNLSLDDAPNAYIKFDKRIDGYTKVLLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P630</accession>
    <name>A0A2R6P630_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P630"/>
    <dbReference type="STRING" id="98765.A0A2R6P630"/>
    <dbReference type="OrthoDB" id="3267487at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR85856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="20006" checksum="CE7C1352F054F217" modified="2018-06-20" version="1">MSLDDREDKAVSVVNKEGISENGQIRRGWWDYVPEHSLSDTQLRHISPRTRTTSDHSGITQYTGSKLQNTRSYPQGEVPVLVPHRKPSLPEGRPIRQPSRTSTVTFSSSNSRDTPGGGVRLTVPRRNQTYPTIPPSPSAVSRLSKYMPRLQLFRQVLKNEVRKANYKNLFDVTDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8U6</accession>
    <name>A0A2R6P8U6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8U6"/>
    <dbReference type="STRING" id="98765.A0A2R6P8U6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="33863" checksum="91EF493B9E0B95F6" modified="2018-06-20" version="1">MPPSHETDPIYCEDLAHPGEGCLREFPNKKKAGLCNVCEALGTFDEGSDKYLEAKARETAKAKRTEAFEARTNQQQKAATSVQSQANPLVAAIPHSDQALDTQSVRVARQASSGSNRTSGQGGGPPVRYITVQCDPKLNGKKTPEFGIRLASHSADTPMGGENKSDCDIRFKGNINIIRNADSMTLGDFYDTHAQSSQRESYLGKDCDAKNKGKYQILHLEIYINKELFTPSDGKGSYVAKRHIDIGAGLNIVTIAENHLNLIAELRRLKLGQWFLDAFYQHARNLGASVSEGMERFLIMKSILTCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8Z7</accession>
    <name>A0A2R6P8Z7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">ATP-citrate synthase</fullName>
            <ecNumber evidence="23">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">PHLCEN_2v5194</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 23">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 23">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="23"/>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8Z7"/>
    <dbReference type="STRING" id="98765.A0A2R6P8Z7"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 23" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="29">
        <location>
            <begin position="2"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="28">
        <location>
            <begin position="293"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="27">
        <location>
            <begin position="540"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="26">
        <location>
            <begin position="704"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="24">
        <location>
            <position position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR036511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR036511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="PSR87377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1152" mass="125294" checksum="AE0C9A62B5061884" modified="2018-06-20" version="1">MSAKPIREYDAKLLLAYWLERAPSVDSSASVATKFVFPSPKVAQVSWDPATNAITPDTQLPGWVFNTKLVAKPDQLIKRRGKAGLLALNKTWDEAKEWISQRAGKPQKVESVTGTLNNFILEPFLPHPSNTEYYVCITSQREGDSILFTHEGGVDVGDVNAKALTLNLPVGAHFPSRETIASTLLPHVPASKKETLVDFLIRLYSVYVDLHFAYLEINPLICLDGVNGGEPTIYYLDMAAKLDQTAESICGPKWAIARDLTVYEPGAQGTTSKGKGVSADRGPPMVWPAPFGRDLTKEEAYIQKLDGSTGASLKLTVLNSEGRIWTMVAGGGASVVYSDAIAAHGFAHELANYGEYSGAPTEGQTYEYAKTIVDLMTRGKPRSDGKILIIGGGIANFTNVASTFKGIIRALKEYKGPLIAHQVRIFVRRGGPNYQEGLKAMRLLGESLGVEIKVYGPDTHITAIVPLALDIKAAPKNPLHSVPPTAPGSPKASSQGPAYSEPGVGSIQEDGERVQANDQIVHFDTVDQTARPAYRPFDATTRSFVYGLQPRAIQGMLDFDYSCGREAPSVAAMIYPFGGHHIQKFYWGTKETLLPVYTSVEEAAKKHSDADVVVNFASSRSVYSSTLEILNFPQIRSIALIAEGVPERHAREILHLAKAKGVLIIGPATVGGIKPGCFRIGNSGGMMDNIIASKLYRAGAVGYVSKSGGMSNELNNILSLVTNGTYEGIAIGGDRYPGSTFIDHLLRYENDPECKMLVLLGEVGGIEEYRVIEAVKQGIIKKPIVAWAIGTCAKMFTTEVQFGHAGSMANSDMETADAKNAAMRRAGFVVPDTFEDLPQVLRETYERLVSTGTIVPQPEREPPVIPMDYKWAQELGLIRKPAAFISTISDERGQELLYAGMRITDVFKDDIGLGGVVSLLWFKRRLPPWATKFIEMVLMLTADHGPAVSGAMNTIVATRAGKDLISSLASGLLTIGSRFGGALDEAASMFSNARDTGLTPREFVDNCRKQNKLISGIGHKIKSVNNPDLRVELVKEYVRKNFPSHSLLDYALAVEKVTTSKKDTLILNVDGCIAVCFVDLLRDSGAFTPDEADEYIKIGTLNGLFVLGRSIGFIGHHLDQKRLRAPLYRHPADDIFINMADVSQPRVLGKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P957</accession>
    <name>A0A2R6P957_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000518">
        <property type="protein sequence ID" value="PSR87081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P957"/>
    <dbReference type="STRING" id="98765.A0A2R6P957"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR87081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="335" mass="37792" checksum="3C30512CFD2D9059" modified="2018-06-20" version="1">MDPSLYQIITTSRGLKYSYYFSPAHPSKLTLLFCHGFPSTSDDWHHQALYFKGKGYGVIVPDMLGYGNTDKPSDPALYVSSAMSKDLVEILDKENIVQAVAIAHDWGCKAVSRLANYYPDRFIAYAFFAVGFLPPRPGTADFGDQLKTEKATYGYELSGFYLFFSEDDAPGIVRDHIDSSISILFPRDPKVWETRMAPTGTLEATLLENWETPLPSYMSEEDKKAFKTTFLKNGFEGPLCWYKIMTNNIQGEDDKKIPSTQVVPPSSSPIFFGAAKQDRICLPEIGYQTFSDKSFNNHTVTTHEYDADHWLILSKPDEINRDLEAWIESSGIEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBR5</accession>
    <name>A0A2R6PBR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000512">
        <property type="protein sequence ID" value="PSR88464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBR5"/>
    <dbReference type="STRING" id="98765.A0A2R6PBR5"/>
    <dbReference type="OrthoDB" id="2976273at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF6">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="130"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR88464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="242" mass="26016" checksum="AA7786B743EE3C48" modified="2018-06-20" version="1">MSQEMAGVNMRLEAGAVRELHWHQTAEGPGDLWYFPAGVPHSLQATAESTNGTEFLLVFPDGDFSEDSTFMLTDWTAHIPKEVLAKNFQVDISAFDNIPATELYIFPSAPPTSNTAVSDPQGQVPQPYTYSFSQVAATPLSGGSVKIADSTTFNVSTQIAVAEVTVAPGAMSEGQGRITLFASSGNARTYNYQAGDVSYIPASYGHYVENTGNTTLKFLEIFNTGKDISQCGTFDMLIEGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCA1</accession>
    <name>A0A2R6PCA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCA1"/>
    <dbReference type="STRING" id="98765.A0A2R6PCA1"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR88902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="468" mass="52001" checksum="4AD5B9EC377D4DD1" modified="2018-06-20" version="1">MIHDELTLDGSPNLNLASFVHTWMPDEANKLMMENISKNLIDQDEYPMTRISMLADLWHAPDAHDAIGTATTGSSEAIQLGGLAMKRIWQAKRKAAGKSIHEPGPNIVMGANAQVALEKFARYFEVECRLVPISEESHYRLDPQKAMQYVDENTIGVYVILGSTYTGHYEPVKEMSDLLDKYEASTGHSVPIHVDGASGAFIAPFATPNHLWDFKIPRVVSINTSGHKFGLAYVGVGWVVWRSKDLLPKDLIFELHYLGSVEYSFSLNFSRPAHPIIAQYFNFVHLGFEGYKAVALDDLKNARLLSRALERSGLFNVLSDIHRPAPGLLSGVKNTIGFDESDAVNYVPGLPVVSFRFSDKYRAQNPDVQQKWVQTLLRAKGWIVPNYELAPDLENIEILRVVVRESVTADMVDRLVSDIVEIAEDLASSDSPTHALNQLQSNKSAEQHHGKLQKGEGSSSNGTYAKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCF5</accession>
    <name>A0A2R6PCF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000512">
        <property type="protein sequence ID" value="PSR88457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCF5"/>
    <dbReference type="STRING" id="98765.A0A2R6PCF5"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="237" mass="26770" checksum="C648F9DA3F5A5FA8" modified="2018-06-20" version="1">MDRPAYNIQRLPCPSCKRVFRNTSGLTQHRHTYHSRPHGHVLPAQPVLQPNNGPQSISPPPNNVPVNNLNPEGLYYQFHSKLNGRPCDSSGQFLLDPNAQPLPQARLETDWTPYNSRLEFETAEFLFQCVKMGQVNVNLLLELWAASLVPYGGRPSFSSIHDMLQVIDSTPLGDAPWTTITAKYMGALPANPPPWMVATYEILHRNTLVCARNMLLNTDFAEEFDITPYREYSGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCY5</accession>
    <name>A0A2R6PCY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v4938</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR88976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCY5"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015327420" evidence="11">
        <location>
            <begin position="23"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR88976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="27218" checksum="17AD872499CF8CA5" modified="2018-06-20" version="1">MRFQTILGYGMGLAAFLQIAAASPLDEPEVLAVASFPEENAFGHVVNGEKNDVFLAVENKSDRNITLQSIAGSIHHPETNALVKNTTALTYKVPLLGGAKIQLPYSFYSEFKPGDWRLNIWIDHTAEGEKYRVQAYDSIITVVEPEVSIFDFKMLSTYAIVIALLGAIGYYTYLSFAPQPKKRKTPAVSAPVGPVTATGAGGYQEEWIPEHHLKKPKARKTKSTALTSGDETSGAELSAAEGKRRKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGS3</accession>
    <name>A0A2R6PGS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGS3"/>
    <dbReference type="STRING" id="98765.A0A2R6PGS3"/>
    <dbReference type="OrthoDB" id="2778810at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="251"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR90675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="584" mass="66461" checksum="6D6D8902F7C95FF8" modified="2018-06-20" version="1">MPPSADGADGNPTGGSDTHTAREEESGMTLKRLDVWIQEWRLRMRMMSVCVEGARDTHGGALVNLIHGYADTGDPFVRKFTDQLLEEVSNPFFATLHKWLFSGELNDPFSEFFVAVDPELAHVQYVQQSSSGGQLAGDGGFGGLGAEGDDVSGEREGGLKLWEGKYQFQKDMLPAFVGEAFGRKIFSTGKSLNFIRYSCNDSDWVVTREKLSNTGGTLKYSDIAGLERSIDTAYQIASRRLFDIFFEKYGLLDHLRALKQYLLLGHGDFADQLMETLAPSLARPANTLYRHNLTATLETAIRLSSAQNDPVDVVRRLDARMLEYSHGEIGWDVFTLEYKVDAPIDTVLDPEAMIKYLKLFNHLWKIKRIESTLSKGWMRIASGARTFLRVPELNHDWHQVQIVMAEMIHFIRQMEAYCQLEVIECSWKILLEFVHKKEGDLDALIEAHRAYLDRMVKKVLLLNPKAGREENLLNQVRELFSVILQFREATDDFYNYCLSESARRDAEKDEQRGIFTTVEPRHGPHTLSEILGRIKEYSSTFSERIQTIVQGLQSHADLDCRFLGVRLSFSDFYKAKKEPAQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMW9</accession>
    <name>A0A2R6PMW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMW9"/>
    <dbReference type="STRING" id="98765.A0A2R6PMW9"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR93759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="348" mass="37935" checksum="DD6D33937F96D04E" modified="2018-06-20" version="1">MGRKIGHPIRYEDHLSLQSVMSEGQYGPAYSLYGIISHAGGGPNSGHYYAHVKDAKGRWFEMNDDSVTHSSPPLGQKNAYMLFYIRDKGQSLEAALKKPVSVAPRNIVAGMKRKKVAESDDEEATGTPPVRAARFIGPLLPSRTDAAQQSPSAKARVKPSALDPQAAMLKKKIADKRSSISSPKVSAALQSLSQYAEDDDDDDKNGDAGEDVGERIDQPVSSTPTILATEPTSPSTSTPHPTTPKDVAAPSIVSDRISTESFYGSSTGKSTHRSNIKKRKSLDDDDGDAVRSLSKFARTPLTPSTSPRHRHPPFRKPNNPFNRLARSDNLHGSPAFPPQQYKNRRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN27</accession>
    <name>A0A2R6PN27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN27"/>
    <dbReference type="STRING" id="98765.A0A2R6PN27"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015347523" evidence="2">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR93810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="242" mass="26476" checksum="595A597610ABF582" modified="2018-06-20" version="1">MGIFPIIMNILQFWLIDSIVKAGAHQASVALPSDSTRNSINSDEEPLFRSSMDDDDDEPHRHDIENPAPAPRSRSRSKDDRDVSPVDDSKSSEATLATASGSVTPKGVDGNQATTITHAYPPSMASTSSSPASSRHSSISPPKRRRSPPPRLALQPRSPMPAASNPALPSADPVAPPTTTERQADTLYDEKEWATWEDDNNDNWAERVGEEDWTGRRIDAKKATLHDAWTERGQGSVWISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYS7</accession>
    <name>A0A2R6PYS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYS7"/>
    <dbReference type="STRING" id="98765.A0A2R6PYS7"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR98910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38286" checksum="D107DACE5B78D5E1" modified="2018-06-20" version="1">MGKLGLVQFAFEQYARIPPVLQASPSLAGRTVMVTGATSGIGFETAKHFAGMHPERLILGCRDEEKGRKAIERKETGCKTVELGILDLASFESVKAFAKRYDNDRLDILVANAATADSKYATTEDGWEEMLQVNHLSTALLVLLLVPALVRTGKASSLYSRLVIVSCSTHHYGQIYDALKSNNNALGMLETMNDSVYCTREIMRRRYFDTKLLNVFFTRALAHHLPPSLPLIPTIGNPGLCYSNLRNYIGLPHIVIVKVVETLFARTAEKGARGLVWAAIGPDGKDGEHVRGHLRGAYVSAGEVKEPSDGVLGKEGWEDQERIWSETLFILSKVAPEVQEVVKQYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ32</accession>
    <name>A0A2R6PZ32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ32"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ32"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="11"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR99069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="980" mass="109183" checksum="A91330BBAA7FDD5D" modified="2018-06-20" version="1" fragment="single">PSPDAAQETGWAGIEDHMKEYDEGEMKVLNDDIDALLIFAGLFSAVLTAFVVPSYLLLQPDNSQLSVQILDRISAQLARFEILPPFINSTASDSASPAFQVSTSARWMNCLWFLSLILSLSSALFGILAKQWIREYLQWRKVAAAPRENVLLRQLRIEAWEDWKVSAGISTIPALLELAVVLFLAGLVVLVWTLDTVVAIVITTAVSVVIMVLCTVTVLPAVYRRCPYKSPTGWACVIMFDALAMVVSWTRWHFRWLAKCVHILWDAHWFTTFMTHLNTVAIKVQKWIIQPAGDLATTCSSHIRRVLSDGSESPPSFPRFSNWRERDLYVDDSGSSEISDLNNIEYPHSHPGARGRVAKDICEVMPLVRALSWVRKGTEDPRLLKHVATSAESLHTDNLYAGDCYYVFMYVLRKLCSAKSKSRELKSLSDFEGQLRSTTYKAVGDGHNMFRRGVYSLYDYLDLQVDLLDYSDLWVLGFLLLGDIMHMLGHNFYTLPLFACLSKHMFSVFRYNQDFDMGRTRLQKIYNDAIDSQSTSHQKLRSSGVHTMILEVLCSMSQVHMAEGTKRISADGPRVSRYMDNEMRLAVQMFDQNAGYSDPFARHQFVMMADLVMRSLHACWVADTDLMGTLLEKMSEAVTISLKEGYENCGCYHELPWIGSILTLRDTTRYMFASSLDRLPARPLWSLMEGLEKGLPAEEPNNQGWTLLTGENIRTDFFKLKWRLEMVHPRQRLAYGPMTDVDVPPSDSQALNLSGPLSLKGPANAAVDSDNGDMQSGGNDGVDFESCSKAAHSSQHSGEFRIEGALQAVEFGGTSHTPSNESCRDVTGQTMGLEGLVNPEDPHIPSSPLADLTLVGDRGDKVGQPPSSEMGLSDSFAISAGDDTRWTMPLSPSVSNSDASSTESPSHNDVLLTDVQASDNVVHPDDLGHSPNSLLVRSSDSASYAGRTITRNSSSSRDRDEEVQPSEHYEVSGEMAEYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZR3</accession>
    <name>A0A2R6PZR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000421">
        <property type="protein sequence ID" value="PSR99301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZR3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="14007" checksum="F4B7F386618066ED" modified="2018-06-20" version="1">MFELRVSRCNTSRPSSPAKIKVVKHCLAAIDNYKQAIFTDYTSWLEQFKPDESVFGDPLIKTLRDILPTKGDTWQVKRLEEPSQCIVPTTASGNGCCRCLLFDEENSETIWGYQRVGFAVWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZU4</accession>
    <name>A0A2R6PZU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000420">
        <property type="protein sequence ID" value="PSR99341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZU4"/>
    <dbReference type="OrthoDB" id="2987506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="443" mass="48948" checksum="C19604D9D9D79B47" modified="2018-06-20" version="1" fragment="single">MATYTLTVNVNSADLVPLKEAGYKLCIAKRVNDKYDVVWSGSDFFTKNTFQWNVAFQVFGSQKFEGGLLVGSDTEERTIDFGEICTLDKYGSMHPAHGAKDTSGVLRVENQYGAMHLGVNAKLGEKWSAIYLSDKPFYTGEIKLTPIEKVVIWFDSKSETGTMLVGAITDCIELDFTGSAEPQSVKYASDPKTPGKGGWARGEQFILSSTYHIDTDTFSFEPPSAPLVAKLTDIINSQKDRQPSTLSLSALTEFHEQGAAQTFAQYALEHQPDGIRTWEFTHSGHIVESKLKAQEDQDDDLAVRFLQDAYLSVLYSFQGPKYKRLSFDVHGRSSSPTPVVAPDPRSTGELRIIYANRFQAAAAVNGINAMAQNGLNYAAAVRGEDSESLRVKLSLQFPTGNVDQDRRTIVDPLATALFGGAYNFLLPPLFPHAPQFVYETVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBE4</accession>
    <name>A0A2R6QBE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBE4"/>
    <dbReference type="STRING" id="98765.A0A2R6QBE4"/>
    <dbReference type="OrthoDB" id="429183at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="61"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS05458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="275" mass="30826" checksum="0508725D669240C1" modified="2018-06-20" version="1">MSIDDDARMGDLEAGEGEPLYEDGSIPMPQPTRSIYSMTRDEITKGIANRFVHSRTYIILYLAMAALSVTTVVLSLVNGCPTLPFYILELIINGAMILEVSIRFLAFGRQFWKSPFNIMDLILTAFCVITLVVIFFAGCGNTSKEEELLDTLLLVARNVLQFGRLASVMRQYAFITRFTTYESSDHDECRSGQSIFSRPKPIDLSSARRRAFTLDIDMEGEDPGDELGRPLIRDSVVFDAGEEQRQAPRTTMTPMPRAAQALEERDAEDVWAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBN2</accession>
    <name>A0A2R6QBN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000367">
        <property type="protein sequence ID" value="PSS05549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBN2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7218" checksum="259C187D164DCC88" modified="2018-06-20" version="1">MNPTDHISSGAAVRRLDLCTWADSIAEHDSELYPCRIPAVRTERTAWASRIARELANVAKTPLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEL2</accession>
    <name>A0A2R6QEL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v3642</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEL2"/>
    <dbReference type="STRING" id="98765.A0A2R6QEL2"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS06584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="573" mass="66882" checksum="D1E936A321881F27" modified="2018-06-20" version="1">MAISGQMLGFNPKDHDGHFVGLDSSIQDVSGVRPDVEVSGAPEPPSPFKPWKLYPRPPPPHWHWTDKEAVPHTPHDYSQEEFVFENCEIPGPDNWGFEIDERGVYQVYENVEAQDKKPLFNIPTIREYFMDLEYLLAVVSDGPTKSFAFRRLGYLSSKFTMYSLLNEFQELADMKDVVIHRDGKELTLEQVFESLNLTAYDLSIDTLDMHAHQDSFHRFDKFNLKYNPIGESRLREIFMKTDNYIEGRYLAELTREVMTDLEQSKYQNCEWRISIYGRSPDEWDKLARWIVKNKLFSHNVRWLVQIPRLYDIYKQSGSVKTFEDILHNIFRPLFEVTQNPATHPELHVFLQRVIGFDSVDDESKAERRFHKKFPYPRLWDAKESPPYSYWVYYMFANIASLNHWRRARGFNTFVLRPHCGEAGDTDHLTSAFLLAHSISHGILLRKVPALQYLFYLKQIGLAMSPLSNNALFLTYERNPLPDFFKVGLNVSLSTDDPLQFHFTKEPLLEEYSVAAHIYKFPQSSLAELARNSVIQSGFEMEIKRHWLGQKWYLPGAAGNDIHKVSQLEYPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIU0</accession>
    <name>A0A2R6QIU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3413</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="MLYV02000328">
        <property type="protein sequence ID" value="PSS08923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIU0"/>
    <dbReference type="STRING" id="98765.A0A2R6QIU0"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS08923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="328" mass="35929" checksum="3F7BF19470DBF4C3" modified="2018-06-20" version="1">MTTSLDQLKQTGTVVVSDSGDFESIDVYKPQDATTNPSLILAAANKPAYQRLINNAVDFGKSKGGDVDVQVNAAMDRLLVEFGKEILAIIPGRVSTEVDARLSFDKEGTKKKAKELIALYKSVGVSKDRILIKIASTWEGIQAARELERDDGIHCNLTLLFGFGQAVACAEAGVTLISPFVGRILDWYKKAKPGPKYEGDEDPGVQSVKKIFDYYKQHNYKTIVMGASFRNTGEIKALAGVDFLTIAPALLEELKNDTSPVPKKLDAQAAAQAAPIAKVTYIDDEPEFRWTLLQDQMAFDKLHEGIKKFAEDGETLKQLLRKKISGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM29</accession>
    <name>A0A2R6QM29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000326">
        <property type="protein sequence ID" value="PSS10459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM29"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS10459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="15205" checksum="E2A3B6779782AF34" modified="2018-06-20" version="1">MSLNYQNYQVKQGNFNSLKFTQPLEETIKQAANKVEKWPGYPKIDFYVRLPSNASNSQLHSEVVKEFWNWFMRHKDEFSGHEEWRFPDYDNGDIEITGLCAVEGPFDKNKRCEWHLDIKLQRGYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM57</accession>
    <name>A0A2R6QM57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v3302</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM57"/>
    <dbReference type="STRING" id="98765.A0A2R6QM57"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="442"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSS11006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="741" mass="80642" checksum="DEC269E8B91364CE" modified="2018-06-20" version="1">MSAAPATPLYSSPPLSKMDDPTTLVSSKSEPSASAINPELASAANPTFSQGLQTVREPDSEDNIFVAAQRGDVDALRSLIESGKAKATDRDSQNITPLHWAAINAQVAACRFLLSQGAEVDALGGDLVATPLQWAARNGYLYVIHLLIAHNADPNIADAQGYNTLHLVTHSSNVMPLLYLLHQPINVDSRDSQGHTSLMWAAYQGDALSVDLLLRHGANPNTKDDAGLAPLHWAVVRGNRICIRKLVEAGADLSAKDGEGRTARDMAVELKSLGAWKRALEEGGLTEDGIKKKKPLSERNIKITIFMLPTVFLWLMFMTLTILPWFTGVILAMALFFAMHHIVTRILLDKSNYTDSVTQSPYFAGIIFASMVWVGYAWGSRLLRQTQSHAFTHLIFALTVGLCAYNFFRAISLDPGICPKPASDAELKSIVEELATEGRLNGQTFCIQCMARKPLRSKHCRVCDRCIARHDHHCPWVWNCIGVNNHRQFLLFVFTLVVGIALFDYLTFAYFATLSASIDPARISPSCILPEDLCALTASDTFLVSVACWSTLQLSWTLVLLASQLWQVARQMTTLEVSNLGRYGFMGGRGGASLGQQMGHQHHQHSPSDEGGAGGAHGHNHKHSCCGGGGFIMNLLGFDRFTKGKAADGLARAAKAPNPFDLGVLGNCKDFWTSGRELGVEYERLYDVPPEGFLEAKRRREEGEDGGGGGGRKSLRKSLLMGIGLGRSGSSRGGYEPLSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM94</accession>
    <name>A0A2R6QM94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM94"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS11041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="165" mass="18636" checksum="7BF56B48483FAE12" modified="2018-06-20" version="1">MAGLVMFGLLRRRYDISHRLKTSNSDLPVQTCLRLLVMCVVQTSLWVCVIAFSLWDASAQGLLPWKGVHIDWSYIGQYTVVSLPPGSLQRKLFCWWAVPASSLVTFGSLSFGGECKSEYIRLFGWVCKVMSKERTQEAIMLRTMSVSKRCVFSLLHIGHLTEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R102</accession>
    <name>A0A2R6R102_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R102"/>
    <dbReference type="STRING" id="98765.A0A2R6R102"/>
    <dbReference type="OrthoDB" id="3219024at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS18920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="484" mass="51982" checksum="FA2031A3EB574BBB" modified="2018-06-20" version="1">MPTRAHTLRPGQLARTHSRTSSGGGSKVGLNLQLTQKEPAPPRFPDKPKKNQLLHEPNNKSSVHLSRNNSSVRLQSKEHVNPSVFRRAPTPLGNNKGSSSKGRVGFTISSPSEGDDDDWVSSESGAATPVDSQDSDVEEVAVTPVEKHKPRLPTITNGFVKDDHPTPRADPLALPRVETMRPSQETGPLPAISAVSAYAPAQRQSSQTIHPPPQRLNTPPVQQLHHQQSLRPESQPTPPHVTKAHSETHSPPRRSPDAPKRQAMTRPPSTHSITNSSVHAMRPHPLIRANSAGHGALLQPAKPAPLAPLTTRLVDSVPAQMSSASSPTSLRAVSPTFNMQGSSVSPVLSQPSPTGSEASKQLRRTSTSSRSSVATIPSGAPLLGSASHAQLSRTTNHDRQRTLSSSSTFAALSNLNLVRGAPSPPKTPVQHLTVRFPPMEQIAQSESVHTLLPPPYLSAHLTMLAHRNPLGESYDRVMRAKQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RBK5</accession>
    <name>A0A2R6RBK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000264">
        <property type="protein sequence ID" value="PSS25956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RBK5"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS25956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="863" mass="96960" checksum="89A4D59F4016A8FD" modified="2018-06-20" version="1">MPRRNTYNILRFDCQHCNRSFSTQGGLKKHKNSAHKEAQFILPQASTSPPTNNFRSTFEYQDEPSDSAQEFPGDAGTVPLPVESTYYHPILNVPCNQDGNTVPKNTPPAPSKVQNDDWKPFEGRIAFELGEFLYKEEQMSQRKINKLLELWAASLLEHGGTPPFALQQHMYDTIDAITVGDVPWKTFSLKYSGDVPDGDTPSWMLADYDIHFRDPNLLARQHLSNPGFKDGFDPIPRRDFDSKGGRVYNDFMSGSWSWKQADILAQDSKNCGAMIMPLIFGSNKTTVSVATGQNDYYPLYMSSGVITNPYRRAHCDSVVPIAFLATPKAGRKYDKDPVFQKFRWQLFHKSLAFIMQSLKPGMTTKQLMRCPDGHYRHVLYCIGPYIADYPEQALLTGVPFTNDFPRADIHELIAPDLLHQIIKGTFKDHLVTWVGEYLILEHREAAGNAILDDIDRRIAAAPPFPGLRRFPEGRRFKQWTGDDSKALMKQFGAPNGLCTSLTESRHITAVKEPWRRSNRFEALGQILTINQRLHKLGAARADFEERGMLKGNIISATLNALLHAQGESNQEDLLLLAEDHSAEVPVGESIGVGLPAAQDGATVSGSQTEQASLPPDDDESPVDGKQIVGFVDLAKTPQRGYPRTLLGLGQYMGCPSLADHVRRFLYDQMHPNSNHSSADLELEECPSLPDSQRISVFHSACATFYSPSDISGLGGMKSEHIRSCPRWRGKEERRDCAFAQKDSSIPGIKGLYVVRIRFFFSFQVGGRQGVVHPCAFVEWFKLVADERDPVTGMWVVEPELDVDGTRDVSVIHLDTLVRSAHILPVFGDEFLPTDFHFLYTLDAFRAYYVNQFADHHANELIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHU8</accession>
    <name>A0A2R6RHU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHU8"/>
    <dbReference type="STRING" id="98765.A0A2R6RHU8"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS29606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="661" mass="73833" checksum="B54B9DCFF4040E29" modified="2018-06-20" version="1">MTSATPSVIQKSTGPNPKRPTNSKMASNQSLNHLLNFSLPPRQAHQYQSLPRRRKPATHQVVWNKERFINAQYRFVVNPSGDYTVHFADPDIFFQWQDILQVIIPRSSALASAAGSGEISGHDEGLTTCPICLSPPTAPRMTKCGHVFCFPCILHYLNTSNNLKWARCPICFDSVNERQLKAVKWIDVALMDEEDNTPPVPSSSSSNADYGLDSGPRLGSVLRMRLIQRPQITTLALPRSPTWPSDLMPPHQAPFYFLPDVGTFSKFMLATPTALITDLTKDLDDLVSERRTLTSMHDHLGVIYIDMADGKLRQQMAKAAALETPQLKEAVDAARHALHHIVERAALHSRKVREDQTRSDPPEDAPDDLLASRPSGFNTPTSTVNPVSSDDSRRVSTPTRAPRQRRNLNPPPPSSSSYYYYQAASGMPIFLHPLDIKILLSYFNSYAAFPDSINVRVESYAESTVNDDLRKRCKYLAHLPEGADVVFVETDLGSVVGQEGLKNFERALVMRRARRKEKGRKDDKARARAEEREKEKIVNRWNELTRHDVDAYIPPSEPRVPSPVNVDNAYDFPEPGQAARPQLPPQTPSAWGARSFASAAQHASQGARTSTQPRPVRRVPEEDEWELDVAFHDLEQRAGRGGGKRRNNRMVVLGGGGGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHV3</accession>
    <name>A0A2R6RHV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHV3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7308" checksum="F6AADD18BD9D7E00" modified="2018-06-20" version="1">MKRDNLGQSRQMGGTLGHACASVSTLCRDGKKANSNQGVTTNRDQSLPYLGGACTWPDEEDHEWNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI51</accession>
    <name>A0A2R6RI51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Antiviral helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v2845</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI51"/>
    <dbReference type="STRING" id="98765.A0A2R6RI51"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="290"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="573"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="492"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS29697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1229" mass="137794" checksum="DBE3E94ABCE56D91" modified="2018-06-20" version="1">MEDDEHLESVEQILRPKHNHAEKILNDLGLDGLPSQERVYQEIEEKLLLPKEKLPSHWLPTYQIYWEDKLSIPDLLSFEPSPPPTSLAFVRSGLHGRVTGYTEVPNPPVGTGLTSSSLDRAPGPSTNFVRGKSGYMPFWPGGLDDVRKDAFTVKELDETSNGLRKVPPGLSRGLRLPGAELEDMLVGLEGISHKPSGGDIPNGNDDQEYPEPILQDQFGSSEIDDLLPASRTHLKPVTSVHRPLRRANVQKRDWAHVVDINKPMTNFHELVPEMAHKYPFELDTFQKEAVYHLEMGDSVFVAAHTSAGKTVVAEYAIALAAKHMTRAIYTSPIKALSNQKYRDFKQTFSSASVGILTGDVQINPEANCLIMTTEILRSMLYKGADLIRDVEFVIFDEVHYVNDAERGVVWEEVIIMLPDHINIILLSATVPNTREFADWVGRTKKKDIYVISTAKRPVPLEHYLYAGRELHKIVRADRTFLTQGYVSAGEALRRKQDKEREAAGLPPVQKLGARAAAPQRGQRGGQPARGGQRGGAPTRGASSGGRGGSSRTFHQPDKNLYVHLIGHLRKNALLPVVVFTLSKKRCEENAGTLTNLDLCTSVERSEVHVAIEKALSRLKDADRRLPQIRRMRDLLSRGIGVHHGGLLPIVKEVVEFLFARGLVKVLFATETFAMGVNMPAKCVVFSNIRKHDGRSFREILPGEYTQMAGRAGRRGLDSTGTVIIVASENLPEQGALNTMILGTPTKLQSQFRLTYNMILNLLRVEALRVEEMIKRSFSENASQRLLPDQQKKVVENEKILSILPKLECNNCLPGIGELYDDMANIVDYNFQLLSLDESHRRQGSQKLLQPGRVVVLRDGHFTSKLGVVVSIPSGREKLKIYDILALVDKDTKDGKRDIDDESMPPFWPPEPTSLVVEDGTYDLRPVPLTSIAFVTNRILKIEIDLISAHRISAMNNAIRLLQELLDEWLLSGKLPEVDWKSRTRALQLQELLRTRDGLLQQTSTYVCTECPDFHDHYIVLHGEKVLRANIATLKMAISEQNLELIPDYEQRVQVLQELKFIDDNSTVLLKGRVACEINSANELVLTELILENTLAAYEPEEVVALLSAFVFQEKTDIEPVIPPRLQEGRDAILAIADRVERVQDAHSIPGEEFRGLKFGLAEVVYEWAKGMPFEQITDLTDVPEGTIVRVITRLDETCREVRDAARVIGDAELFKKMEEAQIKIKRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RID9</accession>
    <name>A0A2R6RID9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v2945</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RID9"/>
    <dbReference type="STRING" id="98765.A0A2R6RID9"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="293"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="487"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="571"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSS29797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="693" mass="75279" checksum="7892B03FB38E81DF" modified="2018-06-20" version="1">MAPDLKPIEAKAARWEPSADPHDIVVPGLDASASVNDQIEQIEQLITIKLQNIDANFSKIQHIMANRILPAVKRYAVGTEPVREAAKFWITFFEQAAQIRVPTYEDYDTQQDAQSEAEHEEIQESTNNEASVLETPAHSRVFGHDATVSEVSFAPGQAAISSTPARHKGEEDSFSDQTDATPSWNASIESPLVRLDREIQSLTRDEVSVASSVSQSHSHYDDSQDVTQRQIPATFTEEQTAPRSEKGKGRGKDSAEPLLRGVLRRNVDISSTTAHVTATSPLKVRGKTPVLKSLNPYLPPDTNPSDWKGLVDLADPTVSTPGKYTKSPTKRRFGAQPSTSKRPTTPQLDDDSFDEGLGMSPPITMDFARLPKAKTPKLGKTPKKQAAERIVQSLLDVERRGVFDSARTGSTYDISAMAKLGVGASVESSISTVPTPPSFSRYARHPYPLAPETNSSIADASLESMMRRVGLNVPAFGPSYGVPYSASKGEASPSYSSIPTSVFLPPSQSQSSGVPPPDSPETPETFHFNTAHLQDDEFNQEDPDSSMDSLDAFDEANNTANPSAAFIFASQQASHDDDSSFESNQSDDSLDEYDGMGGPIQPFGAEQDGDGFDDDDSFDDPLYNPPTEEETLFGVPPAQRLQAHAQFQNRASDQNLRMLGQELLEDTIGIGTQMAQAGRIEESPTPWGVARGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIJ7</accession>
    <name>A0A2R6RIJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000249">
        <property type="protein sequence ID" value="PSS29852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIJ7"/>
    <dbReference type="STRING" id="98765.A0A2R6RIJ7"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF84">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS29852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="35013" checksum="5D47D8D8B3D06DF0" modified="2018-06-20" version="1">MILEKAFEKTLRAHVVPQLAADEASASDRSRMARESSASKSNTANCTDSSAATCTSSERTSHGNATNQAPLHGISNCPPSVGSCPLPTPLMEGSSTALLAILEHPSASPLKPSKPHSLFHPQARRPEEAHVQAADRGAVIRIAHLGDCMAVLIRGEEIVWRTEEMWWNFNTPVQLGPASSTRPRDARIFTIPVMEDDILILASDGLSDNLWDEDILDEVVRFRRTFFADSAASPTGDSFCSASLRRGSLAGMLSEALCSRARCVSQRRGSQRKASGLPQKVTLEAQNLEDDIPFGRRAREQGKCFQGGKPDDISVLVAVVSPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLK3</accession>
    <name>A0A2R6RLK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLK3"/>
    <dbReference type="STRING" id="98765.A0A2R6RLK3"/>
    <dbReference type="OrthoDB" id="2800760at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="263"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="350" mass="39251" checksum="DAF38CF540A90D36" modified="2018-06-20" version="1">MNFVFNTVTDAGIAGLGIVSDLGIAPGAGLVATALHSIKENCEQIVTHKADCRRLANTAAQLYNLFEEQTKQLEKTPLRPATDEVEQVLLDVREKTLKWASYGRIRAFRYEKTIGDGIKQCHTELENSVRGFQIAAVVSLAAAQKEQMEQMQYNHQEVVERLNQHQEIAERFNKLILTASKDAIIKRGPDPQAEPLLELGHERLREMRDYLNNMTGELRINGQTTTRATFNTTYLRTQDVLSALHTATKLLPNIKSLNGEVVKDGNMPYAGGSFSDVWIGIWLGDRKVALKCLRGIKNTSSTAKRRFENEIKIWSKLQHPNVLSFLGMVTDVGAYLALVSPWQENGNIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLU2</accession>
    <name>A0A2R6RLU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000224">
        <property type="protein sequence ID" value="PSS31001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLU2"/>
    <dbReference type="STRING" id="98765.A0A2R6RLU2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="986" mass="107113" checksum="E0831723642A4D21" modified="2018-06-20" version="1">MSSRIPAPDGTVDDLHYSIVKNSDDGKLSHSTHYIAYRDAIILPAASGAYEGPQHILPILITDGDGAAPCTTIYGENLYFKAGATYNFKSKILKIVAKSINVFGEGVVTFDLHGDDGETSTEDIKPAASGRDGTEDTPSENGSDGTKGHDGGNGVAGGSFSLLASSVIGAFIVNLKGGNGSAGRKGGTGGNGGHGCKTNRSYINTNNTNYTLEELQARYRGSKGGRGGTGGNGGNGAVGGNFIAILPNHCRTLLNVSQDDGSAGAAGEEGDAGKGGGAGECVIGRNGLKSSWRRRMYANAGDNGDAGSRGSAGNAPDSSQKQTILTDFVAQVHFPTAFPPDFLQLICDRLRFEYHILSAVMDLNTPSTDPDARLVKFGETLAWLLLACPAIPAPPVDPNVNVEGGILSDLRSNVRQSILNLKYCINLRTDIWGRRLDSVDSLFFPFYGIKEKLHSARHVEEEYLASKKLNGEINKDRYEKANTFASLVQNEKTLKDKITEAGLRCQELVEKITRAKTVVEDKTRDIATQLRKAEKKIEGHVEWNGWGALLALGTVVVAPEAGIVAGAITVLEGADLDFNGITTGGGDKVQKSYVLRKMTHVQGGVAEIRDKMKDLFKGMGEGSGEGLEMITVEKDKFTELCDEYLEAIGADGPLRMLFQDLQTQSDVLNNIILSYNTEVVQLHKLTSDRAQAKLQQQVLQIVPSQEDEDYRRLHLLRYFYSSTYTKHKMALVKEIASAAAGVRALTFINPDYLASWMDFGCFGAVTVDCLIEAWEVLRTAVEDYQRVESMNKTQEVPFTARIDTVYPFVVDNLKKNRSFIVDLLPKAAASAHWISSIWRDVRLQGLQVFLEGAKHKHPSDHAQISLRVRSLNAFVVHDTMGRKYVVNCPEVILPFAYLAKDRTAACKPVNPNSAQFQLDDPKNTEPMRRCLISPYTTWIVEVDGDVDLSEVDGVTMVFTTQARSTQGKVDSFNLALARMMAAPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPI3</accession>
    <name>A0A2R6RPI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000216">
        <property type="protein sequence ID" value="PSS31905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPI3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="268" mass="28383" checksum="A309DA18E46689DD" modified="2018-06-20" version="1" fragment="single">MVDTRTANATAHPGQVQIQRKRKRRTAAQMKAARDAEEEGKMLDVEKSISSVKQELLMHRIAVLENELVEGRAAAHPSPPIRANLVVQKPGNGGPSASRNAAKNLETPANNSQSAQPFPLSQPRTKYTRAEIATMRAALSTPTRKGAGVQGKMLVIPGQGAGGGKRKSEGNASSNKKAKPPPHSGFRKDYAASSSSKGKGIQVDKVVCWPMTTTLTPPSRTSTTSATGNLTRGMVEGEAIVISSDDDGEGGNNVPGQQLLFGHRMTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPL1</accession>
    <name>A0A2R6RPL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000212">
        <property type="protein sequence ID" value="PSS31964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPL1"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015344680" evidence="1">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="153" mass="16957" checksum="5AB92AFE85C1BFAE" modified="2018-06-20" version="1">MLTEMWTSLVATILLASSVARASLSSANGVYDTSNTPVNLPWNTYNYCNAPHVNANHYSAPPISGAKLVYLNAVIRHHKRTPDNLYPEENPLNTPWDCSNFLQHNYGGPGTTHVFHETNIPSWHPFLIQIWNGTCDEGQLTRGGMDDAVQHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ38</accession>
    <name>A0A2R6RQ38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000196">
        <property type="protein sequence ID" value="PSS32109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ38"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="112" mass="12942" checksum="02F6F40FF397EB25" modified="2018-06-20" version="1">MYKIFRKLHLRLLPFLKGIAWPRRHKAAATQKQPSVQRAFGIADITLSILERLQNKELARCALVCRDWANVVHDILWKGRVDSGVSIRPILGLLDEFYIEHVRVLPSVLYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVX8</accession>
    <name>A0A2R6RVX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1786</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVX8"/>
    <dbReference type="STRING" id="98765.A0A2R6RVX8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31814" checksum="F74B377536F0E074" modified="2018-06-20" version="1">MDDTSKELFALRKAAFAKGDKAVLEQVGEGKDIMSILLNANMHSTESDRLTDEELVAQMSTMLFAGTDTTSNALARTLHLLSMHPDVQERLRDEIIQAADTYGQDIPYEQLFELPFLDAVCRETLRVDMPLNFIVRETVGDSVLPLHQAITGIDGTPIHEIAVPKGTMVLVALAACNRSRAVWGEDALEWKPERWLSALPETVGQARVPGVYSNLMTFSGGGRSCIGFRFSQLEMKVVLAVLLQHFRFSLTDKKIVWNFSGIHFPSMHTDGTTPSLILKVQPLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW09</accession>
    <name>A0A2R6RW09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000141">
        <property type="protein sequence ID" value="PSS34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW09"/>
    <dbReference type="STRING" id="98765.A0A2R6RW09"/>
    <dbReference type="OrthoDB" id="3166447at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="53118" checksum="211B67859C12009C" modified="2018-06-20" version="1">MPALSQDFSGGQHSLAMSVSGLSIRSASSTSSGSSDGLPFPSNKSEFEVEQTKSQFPTKPRRRRQSSDRDSEAAFRACVSMLVSSKARRVSVSGKIPVDPSNLILFFRSKSGITHSMDFPIDVDYDMPPALDVLIAASRPHSPAGLEEFSEHESLFYPPHLPLTTNLEIANHPILDAVRTTLFPTLPTGHYLTVLRDKLQIWLTGSGMRAQPRPNDMRVATILVTLPVKFRGGDLIVRSPEGMEEKYHTKGTKVGDMEWTAFTGDCDHEIEPIVKGCRVTISYAVHLKSFGPASIQADPLITPSDQFLDLLSPVLNLSRGRRVAFFLSCDYDVNPAEALADSLVPHLKGGDSVLYHALKLYKLQPELRWSAGGYIWPVDQVVDISLAVDDAPISPNMRVSFPSPLGSRQSPSPPMRGIGISSVSDIGESTTDDLRSKVERSGAVLLAGAGITLLSDPAASGAISKARVPFVRSGELEKLVVSVMLVVFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZD6</accession>
    <name>A0A2R6RZD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000134">
        <property type="protein sequence ID" value="PSS35390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZD6"/>
    <dbReference type="STRING" id="98765.A0A2R6RZD6"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="452" mass="48699" checksum="D53657C5952B76AF" modified="2018-06-20" version="1" fragment="single">IVDVVNKTLAFHTSVNYELLAPEPFTADVHEDLLGDLARIIKQQYPSDFDLHIDMSRTLKRLNDGHCVYINSCYDSLFLTFLPIPLVFLTDSNGAQAVHIAPEAFTVASAEFADELQVWQNALPGALKGQLSSLSGAKVLLINGADPFVAVDANALITGSFQPFGTRQNSFFSSYNRADTGWSYIMGNFAQLSLPLTDSATLTIQLANSAKTETITLPYRSRIGSTAVPWTDSTSFRENNCVAIDGTNGVDINAPDTSSAKRDTATISPVSKFRQQPKISSADARKHALNVMLDVTPLQDISLPPALTPGGVVSGSLGVSEFHLLNDGKTGVLALGSFSEDDFDTFEQTLLTGLTNLKTMGATQLIVDVLAGPKSTTVPQAGLDTETRAGPLARLITKTIVANPSLDPNDELLYNPIGFAFLNNTVFPADFDWLEPPVQKIINGRQDAFSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZH6</accession>
    <name>A0A2R6RZH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZH6"/>
    <dbReference type="STRING" id="98765.A0A2R6RZH6"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000016">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="10">
        <location>
            <begin position="135"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS35407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="335" mass="37011" checksum="C820BA19CC819E9F" modified="2018-06-20" version="1">MIDTVMDKVRRLADNCNGLQGFFVFHSFGGGTGSGFGALVLERLSTDYGKKSKLEFSVYPAPTMANSVVEPYNSVLTTHTTLEHSDCSFMVDNEAIYDICKKRLNITSPGFTNLNRLIAQVVSSVTASLRFDGSLNVDLNEFQTNLVPFPRIHFPLATFAPIVSSAKAHHEQNSVADMTFSCFETGNQMVKCDPREGKYMACALLYRGDVVPKDVNAAVSIIKTKRTIQFVDWCPTGFKLGICNEPPAHIPGGDLSKVSRSLCMLSNTTAISTAWSRLDHKFDLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGIDSADAEEAGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZL7</accession>
    <name>A0A2R6RZL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZL7"/>
    <dbReference type="STRING" id="98765.A0A2R6RZL7"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS35475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="367" mass="40395" checksum="BBC68AAEE5F5C141" modified="2018-06-20" version="1">MKLVGRHFEKNGAGHVSLRPEDDEDMWHLYNLIQEGDRVRAPAIRRVQNVSSTGSTESHRVRLNLTLAVTRVEWSPATSAGESSASSTDPANTNSQGSTAGLQISGRVVSENPHVKMGAFHTLDIEANRDVRIEKEEYGWDSISKARVNESCIPGRGAEVAAVVCGEAPSIRAIVIASPGWVRDTVLDHIMQEASRTGNKALLSVRNKFTKVHISSPHVHSLVEVLKSPEIASQLKETKFAREGIMLDRFFKMLGTDEMRAWYGPDHVALAADRGAIGTLLISDELFRASDPTVRKKFVRIVEDVKQKGAEVLIFSSMHESGQQLNQLTGIAAILTFPLDVEVVEAEEREAKEEERKKANENGDTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4J5</accession>
    <name>A0A2R6S4J5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000072">
        <property type="protein sequence ID" value="PSS37214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4J5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="92"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="187" mass="21378" checksum="1F72BF4D68A71909" modified="2018-06-20" version="1">MEVQPEINIKKDDRDTEILRIIVSGIPTQAVAEGRPSVPLIHWRIEAVLQHCATVNPNHHYESGVAFDTALRPDVVASPFIQMQAFSHQGAKSRSSKFHPDFNVLVRGWTPMQMLEDLKTANEPLHRYRYDGESSGCLYWCKRVLTRLEEIKKIPAGSAQRLDDVVQEARIAHANIYWIPEDRGSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5F3</accession>
    <name>A0A2R6S5F3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5F3"/>
    <dbReference type="STRING" id="98765.A0A2R6S5F3"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35613" checksum="074AFD5F2424FB0B" modified="2018-06-20" version="1">MPTLFLFQSVQCQKADWPRHKEACRSNQERRESMARHDELELMERQLFGTHKDRPVSSEVDQELREFLKRFRPVICQAGYRCLGVQKGRTEAWKHEAFVMRVKRIKKPDPESRLWSRYKVVDAKAVPLEELAEEYGGDMQPLLKQGEVYHEENVKTGCIGTIMTFLNCDSAGRDLRVSSWAGYHPEGWDDDEPCDDWKAALVSAIERGCGRPVTGTDQLLHTKVITVPSWSVSFRGTSSYPNTLGSRILHAAQYRTPANMTPIPTKQYLYVDDRSQKGVLRRSLHVQVIRERRSVSFAVCRAKEWGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5X5</accession>
    <name>A0A2R6S5X5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5X5"/>
    <dbReference type="STRING" id="98765.A0A2R6S5X5"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="45"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="220"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="74534" checksum="D35B2DA045FFD09E" modified="2018-06-20" version="1">MRWAIHRWCCTHKGQYGRRYTTARLSPPSVQLRPYQESCIEACTDALASGASRIGVSLPTGSGKTTVFITLISLIYPPDGFPDAKRSLIIVNSIELARQAASQAKKLFPHWDVEIEQGTKHQASGLSDVTVATYQTLLQSQRLAKFNPSGLKAIIIDEAHHAAAPSYRRILSQFDPAISNPDAAAPVPTLAHRIPILGFSATFSRHDGLALGSVFERIVYHRDFLEMIKEQWCICSTWLDKAVTRKSTLVFCVNLAHVRDLTQAFRDAGVDARYVYSGTPAAERKALITAFKAQAFPVLLNCAILTEGADIPNIDCIIVARPTRSRNIFAQMIGRGMRLSPDTGKKDCRIIDFVDSTSRVPGVVSTPTLFGLDPAELIDDESIETLEERVNQAKDIEDIQSPDNMNMVPEPKSVAYIEHDDPFSLADGASGAPHIRTLSKNAWVGCGGDIYILECMGKGYIRIEPNTSEDKGEVGFFSGLMPFDLLECAPDPESNYKAVFTPASLPSQTAFMLKISPFQRSREILQARSLADAVKGSDTYARTKILPGPIGLGLLRSARWRHQPATDSQIAFVRKRRDKGFTTARKLQEEVIGSKAFKAAALEDEQMRKLSNLTKGEAANIISRIKHGAQARYEKIMKANNKLAEREKKERQRKARENVAVGPLPPASHYEAQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Q4</accession>
    <name>A0A2R6S6Q4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Q4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6535" checksum="CE9097BF166ED691" modified="2018-06-20" version="1">MLAYLPAFPTHVLGPFSKCSTIWRTSKSMSPVAGKAFVPRYPGPHSMESVVSIQQDRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDN5</accession>
    <name>A0A2R6NDN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v13614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDN5"/>
    <dbReference type="STRING" id="98765.A0A2R6NDN5"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR70463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1092" mass="123111" checksum="78211A5435CBCCC9" modified="2018-06-20" version="1">MATDPQNDAERIRLKRLAKLQGVASSTPRPTPTSSTPSGSNPVRSTPPPKPQTPVKRPADVSPAPSPVPKKKSPPQPAHLDLPSWEDGIISTVLNVTMRKETAEASGYQVVWLKNLATELEAENPMSPKPIRLAADIADRVLIARLELDPQAMSDDLDYLPVLASLPAQQTAFEYLVSCWKSLNGVRSALLKKNHPPIQMQQATAVLDKLRDLIISYAGLTLQEPEMFSQPTGKPLGAIELVAPLVSLSSLSAPLLSMSSSSESTLGPSDIEPFLQDLVRRFEPDNELDDVLGPVIRSLCFHPSLFRPEGLAGGDASWRGIIGGLEALVSIKGIANMITRLPEWNPTHAVANNIETTSLFGPLLRLGVFQREWPSIAAAYFMKAKDRPATDIQSAIASLRGTLKSLQSSMFQIFNALVRASAEAREAVLQYFASAVSLNVKRAGMQVQPETVATDSYMVNLQAVLLRFCEPFIDANYTKLDRIDPLYYARSDRIELKDETRINADSNEAEQWRQQNEAPHGSPPNFISEIFYLTLAMNHYGYQKTITTYEELARQYDDMARHAEMLEGDGSWRGSPLQARTQAAIDAVKVEQDKVQACQLAFQAQLAEPELVFRTISFTNFVSVWLIRSVDPRHKHPNPILDLPLPKEVPLSFRVLPEYIVEDVVDYHCFVIRDAPESLELTGKIEMLLWALTFLTSTWYIKNPFLKSKIVEALCWASMKYDGRRSVLESTMNSHPMALKHLMPALMHFYIEVEQTGASSQFYDKFNARRNIAVIFRTIWDNPQHRDALKIQTRDNIERFVRFVNLLINDLTYLMDESLSDLVKIHEIQEEMKDAEAFARKPVQHRRERESTLRSLERQTISYMQLGNTTILLLKAFTHETKEPFMVPEIVDRLAAMLDYNLDALVGPRCTNLKVANPEKYKFNIKQLLSDFLQVYLNLCDQGEFARAVASDGRSYRKELFEKAARIARNKGLKSDDELEKLHLFVVKVEETKATIEAEDDLGEIPDEFLDPLMYTLMRDPVLLPSSRTVIDRATIKSHLLSDAKDPFNRMPLSLEDVVPDLDLKARIEAFLAERRNKNTAFDKPAEDVVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDV6</accession>
    <name>A0A2R6NDV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDV6"/>
    <dbReference type="STRING" id="98765.A0A2R6NDV6"/>
    <dbReference type="OrthoDB" id="2538319at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="385" mass="42485" checksum="FF8CFC2C8CF031A2" modified="2018-06-20" version="1">MATVTHYIYSRYDPKDRERLRQETGQTEVEVPEEHEDPWQTESSFGAQRRLAAAPRFIPAVVPYDELNNMIGAFPQATIPSTGAEVDASNAVGGWYRSLTRQSSSDITPRPSTAPLPSMQNPSESLISSPKAVMPRRDKNNWFISRALQSEPPSAPATPPPTLADILARDPPPPSSNKPFKPPVFLALGPSNKGWAMLQQHGWSEGEGIGATVARRADARSVPTNTRRKKARRETDRVVVKQEEREVEWDSEGEISELRKVEIVDLTLSDSSDSDDDEVDEPEPFSLPTAIESPPSHTTPLLTPISTTLKSDRLGIGLKAKTVGLHRASKKRITHNQAALAAHIRASEEMRRMKAITGRGSRGFARLAKADEERRKQLLANLNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFF2</accession>
    <name>A0A2R6NFF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFF2"/>
    <dbReference type="STRING" id="98765.A0A2R6NFF2"/>
    <dbReference type="OrthoDB" id="3038990at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="15592" checksum="04A8ABB67D8D1B74" modified="2018-06-20" version="1">MDDCGRLIFALGFIGAIPIIANSFLMLVRVRAVFFNSARIRTFFSFLWAVNVVGSLTLPFAMKSGRGPGGTCVLIKLEPYLAFVAAIFAAIDTLTFLAITYRVLSSLHAADGWSSRINAFIHGDDVGKLHRLLLKTGQTYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGF0</accession>
    <name>A0A2R6NGF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGF0"/>
    <dbReference type="STRING" id="98765.A0A2R6NGF0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="8731" checksum="2A3DE1730388A2A7" modified="2018-06-20" version="1">MSKLSDILEAALPPSTSFSTGMRTTLSPDFEKTATTPSKTNIDHNVGNVENINPYRELAKEFGVEAHLVEALALRLSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGJ5</accession>
    <name>A0A2R6NGJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGJ5"/>
    <dbReference type="OrthoDB" id="3228420at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="13478" checksum="5F0FE48B465D6BE7" modified="2018-06-20" version="1">MPIPEAIASHPPAQKVAGRRMSITARSKPHNTVEQRAPSPQGDDGPIDYPRPAAPGEQPQHHEEEHPRRERQQGLGGPEHERRLQEDMLRKAELNRPRKDLNANARGSGARISQPAAKAFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGV4</accession>
    <name>A0A2R6NGV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGV4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7633" checksum="05ADB6FC489FCBF9" modified="2018-06-20" version="1">MGGSLVSNRGTGVRPRWQTHAGAEASHSSAWMYPSLCKAICSPFCAVEGVWLREAGFGVLGWIFKDFGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH10</accession>
    <name>A0A2R6NH10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH10"/>
    <dbReference type="STRING" id="98765.A0A2R6NH10"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="406" mass="44360" checksum="F8DC512F261898BB" modified="2018-06-20" version="1">MPITTLILDDVSSHYGAEVIKVEPPNVGDPLRVWRELDVDGVSPWWRSIARNKKSVTIDLRKEEGRELVKKLAIKSDVLIENFKPGTLEKWNLGPDDIHPHNPSLIFTRVSGYGQTGPWSSRPGYASVCEAESGFRYINGFPDPETGMLSGPPVRPNISLGDSVAGLHAAFGTVLALLSRKAKQTAGQPGGQTVDVSIYESMINLMEGIIPEYDRKGKIRGPSGSSITGIVPTNAYPCLSSSDAPGKPSFVVIGANADSMYNRMMVAIGRPDLIGPDYAQNHHRVGRQKEIEEGISAWTKTRTAQEVEEVLRAASVPCGKVFSVKEVMENPQTEARGLVEEVWVGDKESGWPVKMSKVTPVLEGCDTKTRWAGPELGQHNREVLVDELGMSEANFLEYQEKGIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHH0</accession>
    <name>A0A2R6NHH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHH0"/>
    <dbReference type="STRING" id="98765.A0A2R6NHH0"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="25644" checksum="E848A87563343332" modified="2018-06-20" version="1">MFVYNAAQIGRLEKPLSGLVLHIGEGGPNSQPSEAAWIGSAMVNNAVVPHITVYVSPSSLNTMRSVYYTKVGTHITVEPLLFNESELDAKAFLSLMAIGSSEGAPLYMQTILSILRELGEQYTYQEFMIRLERKKQDLLPAQLTGLKQRMELLESFLEKPAYGRKQQAVPVRFAAGQLTIVDLSDPFIDSASACGFFEILTRLFVRANVNTGKVLVVDEAHKVAMFPIMTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHR3</accession>
    <name>A0A2R6NHR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001273">
        <property type="protein sequence ID" value="PSR71522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHR3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="415" mass="45354" checksum="BA5AE3E85F565596" modified="2018-06-20" version="1">MTVDINETNDNRDERNEEVEGGKQGTNNKREDAEKAYKELKIENLKLREVLAKGQKKVVDVPLTTTALGPEIGKYAQKFITVIPLVDFAIIHNTGWPNINPQSPQRFSSKAGFKLGIIAEIFDIFPEGSKVPSIIGKSDWFNEVLLRSGLYNLSALKPDARPSATSNGVKWGVCEVTENMIATTCTVALHHLSYDRQFQAIGDQTGFKYMEFYERLLQMLITKQHTPHVKAIKQVWNKVALDGVMPCVVDNPVVADEDADEEGDCCFLQRWEDDEVEIIDAGVDGIFLGNQVDTEPEEHSEPSLPPSLSQAGAAQNVTQPATLSQSAHPVFTPAPHTATLSHSISARSQPPQATLSGETTSTQTMANPEDIAPAAVSRKPTRKTGKGATLGSNTGSKKAAASHSNRRGQSRDDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NID8</accession>
    <name>A0A2R6NID8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 20">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="2 20">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PHLCEN_2v11977</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="2 20"/>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NID8"/>
    <dbReference type="STRING" id="98765.A0A2R6NID8"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000067">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 20" id="KW-0288">FMN</keyword>
    <keyword evidence="8 19 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 20" id="KW-0520">NAD</keyword>
    <keyword evidence="12 20" id="KW-0521">NADP</keyword>
    <keyword evidence="13 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="11 19 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="22">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="19">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PSR72129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="591" mass="65069" checksum="551183ED891ECC85" modified="2018-06-20" version="1">MRNLCCLKAVPYARFLVASAPRAAPDDDAAEGSTSHVNGRQGDGENDGEEKTLTGPQRGKKWSKEERKNKRGANKGRRFQKVRDDLELCWKVASGTQCEFGQECRNTHDIKAYLSAKPKDIRFPSPASISQSPPFVLSVADDEEMADAENPSVDWTVKCPVYEAMGECKHGLKCRFLGGHVRKGEDGQLILTTNEEKKVLAATTEEEVNFAGTESLKLIRTKKFPHPISDVYLKELQNAASEEAKGGSGKHTPLSEPPPAIPEPEQTTPDGPVDHGQVPKVPSSDNTEDLSQIDHPDVPTRFAEKKRLNWTGKTYLAPLTTVGNLPFRRICVDYGADITCGEMGLANSFLQGSKEEWSLVRRHPSESIFGVQVAGSKPQLLVPAAETIAKVCAGNLDFVDINCGCPIDLVYKTGSGSALLDAAGKLGKIIVGMNRALGDIPVTVKLRTGVKDGRNNAHKIMPRLGAEWGAAAVTLHGRTRQQRYSKLADWDYIKQCVEAVREREAEEDLSPVPIFGGGDCFSSQDYWEKIEQSGVDGIMVARGALIKPWIFTEIKERREWDISSRERLEHIRKVRMPRSLLGSYSSFVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIH1</accession>
    <name>A0A2R6NIH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001206">
        <property type="protein sequence ID" value="PSR72197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIH1"/>
    <dbReference type="OrthoDB" id="2793220at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="150" mass="17694" checksum="0B2D53FF6AB7A54D" modified="2018-06-20" version="1">MLSTFHRRRDFMQRGDHRVAKFMVCWDGPYKILRAWPKSSLYELDLPGHSNAFSKFHTSLLKPHVSNDDSLYPSRACAEPEPVFDPETGEDQHFVEQILDRCRRGRGWQYLVRWKDFGPEHDLWLPGSRVDNLEALNVYLRDLGLHDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NII7</accession>
    <name>A0A2R6NII7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001205">
        <property type="protein sequence ID" value="PSR72205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NII7"/>
    <dbReference type="STRING" id="98765.A0A2R6NII7"/>
    <dbReference type="OrthoDB" id="3181669at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60885" checksum="995E5E9768BD9A7C" modified="2018-06-20" version="1">MIRTHETILHGQDNSSHGLTLQPDTLLLLSNLPAELLAEIFQQYVVMMQQESRQESTVYFRPYHWLRVGGICRVLRHSALQSPLLWNYIVITDHVRQECIEEMLARSQQAPLSVRVRIRTDAEQTKSLLSLICAQLHRVQDLEFSGPWNMLEYVSDRMGTENPALRSLKIAKYAHWGSSVYWQEAKLPFTTEFSHLERLTTVSLTLANLPPCFLRPSLKHLEIHANFLPTFPVDFLNILLQLPLLETIHTEDTQRAWEPYREPVNVRASAPIVTLPHLQSVVLSSSGLLCAYFLEHLSFPSDARIDITCLRTLAAERRIEEDYLIPAIASKFNAGSNAPTGVKPSKPLLSFAARLNGKQNTIILEGWPVRDPEIPFGRACPVPKVRLSFSPFAWSNPFLRKFCGALNLSDVQTAYVGDGLPKPKSGFLAQAFGGMHALRVMHVCGESADDLPEVLDITGDDVTFPHLESLTLERVAFRDFDGPEDDDFAARLEKALTARKQVGAIAQIHIRSASNLSAKDVENMRVAGMPSVWDGIEDIERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIM2</accession>
    <name>A0A2R6NIM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIM2"/>
    <dbReference type="STRING" id="98765.A0A2R6NIM2"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="297" mass="34209" checksum="CD10EFADAC95731E" modified="2018-06-20" version="1">MSDSRFVLDNRFAEESEAESSTSQTSRNRDLNPEQEDRSRGDQLSDRSEDEEGDDELGNGMLPEGFAGPSEKVVKPLTAEDLAKFQAVQEKTGVIYISRIPPGMRPTKVRHIMSGYGEVGRVYLQPEDPKRAYLRRKYTSTKKMHFTEGWVEFKDKRVARSVADMLNAQPIGGKKGTRWRDDIWTMKYLPKFKWHMLTEQIAHEAAMHAARLRVELSQSKREQQEYLKNVELARVLDKRAERKRKAGDDVPPPKEYTKKQKKGEFQGDTTSEKRKGRDIREPGNTEKQLSSVLSNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIS9</accession>
    <name>A0A2R6NIS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIS9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIS9"/>
    <dbReference type="OrthoDB" id="2747316at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33810" checksum="2CBC6C54D52BE084" modified="2018-06-20" version="1">MHEITVATAGLHIPDQVQAAIEQRHREIIGLKRHLNTFTLINKRLPPELLTEVFLFYIADKRRFDIRLQDSTLSSPYRYWYKSIQICHVCHLWREIGLCAPRLWNQIVVNPSTTSECIQQMLSRSRQVPLLVKINLGDSMRGTAVTPLVFAELHRISSLNFRVSASTLLQQSATIEVAAPLLREISLVNSHPSKDSSARIPVPKDLPRLERLAISDFRLAHIRFKHSWHDDDDDDDKYSFLGMLEGALSKRKSRGVQLEKLTITHAIKLVDEQQSRRWNIQLEWDGKEDLLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIU1</accession>
    <name>A0A2R6NIU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIU1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="82" mass="9255" checksum="ECCC01B0B11B28E7" modified="2018-06-20" version="1">MYDRTANTTATSEQTLRNLLDVLQELANRDRGQCGSFAPWYPFSSGLAEIIAANLQQIRVEDAMGLPDLQRVGAETFFRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIV9</accession>
    <name>A0A2R6NIV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001196">
        <property type="protein sequence ID" value="PSR72325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIV9"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015353354" evidence="1">
        <location>
            <begin position="17"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="14787" checksum="3CC959CFE121E786" modified="2018-06-20" version="1">MKSFFVLASLAACALAQRLSILEPTTGNSISSSGSFTVELHQAQSTSDVDQVSVVIALTPCYDVCDDPSQWGLATVLYNGAFNPQYNTSQPQKGLYQDFVLPLSGWPTGGSVLSVAHLLDIGALRIPSFDYSAVQVNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIY6</accession>
    <name>A0A2R6NIY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIY6"/>
    <dbReference type="STRING" id="98765.A0A2R6NIY6"/>
    <dbReference type="OrthoDB" id="3181259at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="565" mass="65267" checksum="5963F5FB1E9B10ED" modified="2018-06-20" version="1">MPFTLRRSRRAEPPPSRSLVDVVKSKIRCCHEKKDRSKREYDSFVPQPIRTNDPVRSLTTLTTRHAVYHRYEAPRRPHRIDRLPAELLACIFVLGSEDEVMLPLIVSHVSRKWRAVALQTPSLWRRISLDTRLRLWTAHIQRAKACTLDIEITPQTPIVSNRTVRRGYLAAQTVQVYMHMVTPHLPRWRSLTIEFRHYAPYLWNAALSECCGHNYRLQAPYLEHLTLVHSLNDDTKEFTLFNGYAPRLRSAVIQGIRLTWLPSLFANLTSLDYTHHGFTRGNDACTELYYMLQVSSRLRELRLAFPPPRSHYSLDSHLPDIPGNTRVHLDHLHTLELYVSSGDIPSALIQLVARLRLRALRSLSLRSPMPPTPSRSNRYPQDFAPILYPPFYRLPQFLISLSRFSKVTHLRVDNSWCDRYFVLSLLKSHMTYLKHLTLASAHVNDAFLWALGDDMRRRYQVSYPIPKVKLVGSVKHPEKVSYATLDVLEVINARISGEGLLAVVRRMLGGGVVWVKEVWVKDCQGVDGTVMQRADRFGVGLKVWGNDDGQGRAESRGSMWRKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJU6</accession>
    <name>A0A2R6NJU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v11874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJU6"/>
    <dbReference type="STRING" id="98765.A0A2R6NJU6"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000384">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="693"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR72282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="922" mass="102749" checksum="8D6DE6472C2AA64C" modified="2018-06-20" version="1">MAANKPNKLAFLSMPAPASYVAGLGRGASGFTTRSDIGPAREGPSADVVAEAQARRGEEAEIDPEQFQDPDNEYGLFAGTTYEADDEEADQIYEQVDQNMDARRRARREARENAELAKHRAERPKIQQQFADLKRGLSVVTDEEWENIPEVGNLTRKKRKRDERSFVVPDSVLVGDRSKGEYENALDSRQQTAGGFETPAENGTLTNFVEMGQARDKILSLKLDQVSGTSTSSGLSTSVDPKGYLTSLDSVILKTDAEIGDIKRARMLFDSLVKSNPKHSPGWIAAACLEEHAGRMVAARKIIKAGCEQCPKSEDVWLEAARLHNNDDAKVILANAVQHVGQSVKIWLAAADLEHDIKAKKRVLRKSLEHIPNSVRLWKETVNLESSAVDARILLSRAVEVIPLSVELWLALARLETPDKAKAVLNKARKAVPTSHEIWIAAGRLLEQEAHTPGKTEEQRDKELEVVDKTIEAGVKELRRHQVLLTREQWLKEAEKCEGDGSLRTCEAIIKATVAMDVEEEDRLETWLGDAEAAELRGNVGTARSILAYALKVFPDRRSLWRRAADLERTHGTRESLNAILERAVHHCPQAEVLWLMWAKEKWLAEDVPAAREVLEKAFVANPESEQIWLAAVKLEAENGELGVARELLVRARTVADTQRIWMKSAVFERQQGQTSTALETLDAALKKYPKFPKLYMIQGQIYQSQGNFPAARASFSTGIKAVPKDVTLWILASRLEEADGKSIRARALLDKARLANPASDVLWAEAVGVEERSGGTAQAKTVLARGLQECTTSGLLWSMAIWAEPRPTRKSRSADALRKAADDPLIISTVARLFWAERKIEKARQWFERAVKINQDLGDVWGWWLKFERQHGTSEYQDEVIRRCVAAEPHHGAVWQSVAKDMKNTGKSTKENLELVAAALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK27</accession>
    <name>A0A2R6NK27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK27"/>
    <dbReference type="STRING" id="98765.A0A2R6NK27"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="292" mass="32690" checksum="518558F93B88285C" modified="2018-06-20" version="1">MAPLCKAINAEYANKFEGQDPRTVYSGQVDPEWTVISVGPFEVHIRDIKTGKGFKNIAATLVQNGEEKVLTHMIFGRLTLPEGGRQDDFNLIVEPPSPYASRIPFHTHPSNCKIARTVSRYGFRNYIQSARDPVYLPNAKIPRKGGGIEWAEYVTLKDAEDRLTAPSMAFFADTFLSLPVILPDLKSLDFWLPTMVMTIEFKFPIPKPSNPHCSQRTVAIFSRGQFVNSPSSRHDIYLEIWTAPNDTTEETDDWKEHQRCLAVATQMAVVVPADVNRKKGKSGTPALGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL24</accession>
    <name>A0A2R6NL24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001116">
        <property type="protein sequence ID" value="PSR73053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL24"/>
    <dbReference type="STRING" id="98765.A0A2R6NL24"/>
    <dbReference type="OrthoDB" id="3247308at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="7772" checksum="D82697952636604C" modified="2018-06-20" version="1">MPEMHVQFVNLVSGSHLQVGEGLLSCTPSVQTSQTFALFGRRIMLIDTPGFDDTTKSDTEVLKMIASSLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL94</accession>
    <name>A0A2R6NL94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001104">
        <property type="protein sequence ID" value="PSR73147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL94"/>
    <dbReference type="OrthoDB" id="2771516at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="168" mass="19021" checksum="859C1799B2126B37" modified="2018-06-20" version="1">MTIADVLVLIFTWARTFKDYRDGYRLKLGMPLSRVLLRDGLYSSSQHDIRSADFMEKGTIYFMFTPLLISRFLLNLRQVGDPGDSGTDWSDMTDLSTPQFRVPTFSILTGNLAMPLDYTTDDSSITLGDDRPRRRSRIPGSVAEPSGCEEMTESRSDGILEEKVVIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLQ4</accession>
    <name>A0A2R6NLQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLQ4"/>
    <dbReference type="OrthoDB" id="3260134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="529" mass="57414" checksum="295585BA9FF620A9" modified="2018-06-20" version="1">MRAEIERLLSHPDFAGLSQRPKTPVKYHKQDDYTGAESFRSPSYNEDFSSPSVSSPLRRRNTSILVPSPRSSFASSSSHAELMNNATRNFRKDGEEHAFSGLRCVNDVSSPPELGRFRRYSPLFEPVNFSPNEPSSPYAVDGASSVPESETGSSYQEVLDQAHFCFGSSDDTAYSSQTNYQACYSGGDDNSGVETKFSFLDATSLSGGGGRHVLYNKVEEDQQNTAAFGSSHFYTPAGRSSTPFDHTQLSSGFSGSTFGSSSPSPSFCSRTRHDSTFLGYHSATSALEYENKCTESAQDSSIQETLFDAVNGQLFEDSDPWTAIKLRLNLLPSLDGSTIQSSDGSDHSDVLWELALANDRSGVGYIATSTFRDTSTPNVAEHTTITRRDSGPLEDVIHDTIQHFQLPSEPTSAPLCGKIPSSPLSGEPLQPHSRPVSLYGSRSINSFQMENHDNVEATQPRSKPQMQLPAPVPVVRSPIFTHQTEATVGSCQPCEQPELGPPSASQEPTGSSIAGPSLFGDYTELDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLS6</accession>
    <name>A0A2R6NLS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001085">
        <property type="protein sequence ID" value="PSR73314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLS6"/>
    <dbReference type="STRING" id="98765.A0A2R6NLS6"/>
    <dbReference type="OrthoDB" id="3251205at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="461" mass="52984" checksum="9AC0FF2E50D43F37" modified="2018-06-20" version="1">MSVNAFHGHAHNRICQLTNHPLYRTVLGLEDLETCERVFSASNSVARVIRFASHFHWQQFLDLHFKQWNEDRYADISKFLFNNYKQAIKLITEFTPQLTIYKNSNGITDTDIQRWPEDELRYLKDLQTEPETDAVPAAYVEALITLKKVQADYDSLAGFQFAGTKENACSIVAKRTGVRRRVLMAMTAVEDLEALLQVEERWSENCKEYLAALDYINRREFIRAVCELEGLVIQRLFELSKANLAGTGYKMRQHISKALVRRSAAIKASLDRYNKLAVKQKPKRPTLDYSEVASWCLIGEFELLKDSRYGVLQQPWSLPVNREIMTKYFKTVCAHTELVRLNVEVARLQDWVDREDVHLKEVADSLTVTDPLLACAVKQVYLRQRRVNNVHRARLRTIYKLPGYSGVIPSISVNMSPSDVDNAAVAHELDATDSILVDEDDTLNDEGNRLDEVMERILILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMI0</accession>
    <name>A0A2R6NMI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMI0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="10636" checksum="C9DD53103B303397" modified="2018-06-20" version="1">MSFLGHLSLRRIATTTPFRAHLSHFRPQIRRFSVSSRRTAEESPKSDIWPALNEFKETKVFAEIQSNKELREALLDAMKVMQEEALENMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMX5</accession>
    <name>A0A2R6NMX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMX5"/>
    <dbReference type="STRING" id="98765.A0A2R6NMX5"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58674" checksum="566BAE9257BA8F35" modified="2018-06-20" version="1">MSTRSDSLEECKDQDIPEKITVDSEVDLTAYYERNAGRLVVDPDEARVEFGEQVACRLKLTKDGTRVLWPQPSDDPEDPQNWSDFRKGIQLLIITLAAIVPDFDSGIGTASIFALARQFNTTSGVINNLTNKEVLTKPFRLGWHPRCRSDETIWTASGVVLDTAMRCLTGFFGTAPQVTGLYVVSDIYPFHLQARKLNIWTMGFIISPFLSPFAFGFMVARANWRWTYGIGSIYGLIVLLLIAFLGEETMYDRSLPDPKPIPMPASRLRQRFETLIGVTGARMAKYRSGWKEVNSIWFKLIWRPHLFGILLFEAMLFGFSVGLNGTNIVFLEEQPPNGYGFTQFAIAGCYGTPVVAVLIGELLGRYLNDWIMNVCIRRNNGVFESESRLWACYVAVVLYIIGFILIGAAFQDHLNISCFIIGWGLVEIATMVNTVAVYAYVNDSFPRLQGEISALLDLGRTLGGFSVAYFQVPWATKNGAIQTFGVEAAIVAGLFLLVVPTLQIKGSYLRVECKSVTKWGENRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMX8</accession>
    <name>A0A2R6NMX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMX8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8428" checksum="E00B834604B8374F" modified="2018-06-20" version="1">MGVEAVNAKLERIDTQVESFILLRGIFQGGFRGTLVSTLNTNWFHITKREEKLRTIVGLRIAFMQSGLSSFQVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN23</accession>
    <name>A0A2R6NN23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN23"/>
    <dbReference type="STRING" id="98765.A0A2R6NN23"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26950" checksum="B877E9A8B6DDCDA9" modified="2018-06-20" version="1">MLASKVICDDTYSNKSWSIVGQGMFALREINQMEREMCSYLEWQLNVEPNQLREFEAKVRRDFKGPGPYPNYAVPSPAPSPMPSTSPYGVGSTSAAPSFTRHGPSVSPPKSAPHHPSSNPIPIPERAYPSPTSSPEAPDTPEASHSASTSPASTASPRTPGGVEDYTAQIVSPDGAALHMDARAAMQIAIAQQAKRTSASAAPIPSSRPQPHHPQQQQQQQQQRSRDPVPQVSKRSKCGELFAFAAPISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNS3</accession>
    <name>A0A2R6NNS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNS3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015317702" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9815" checksum="3EA0A06F613B3644" modified="2018-06-20" version="1">MFAPVHCISFLLASASEQTQVVIRQTAEHEKETRENTVFDRHGYVNRRGDFTRRHKTVRDIFVSCERGDVVARRKKRQPEQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNU3</accession>
    <name>A0A2R6NNU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPP4R2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNU3"/>
    <dbReference type="STRING" id="98765.A0A2R6NNU3"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33395" checksum="D00B1083556551E9" modified="2018-06-20" version="1">MTGQSSFEWLPVNLSRGDSAEWTRLQEVIKYKLDKNIALYLSQSNELPKALAVPFAPRPLPSGGLKLPPFPAKTPKDRRIDPPKIILTAEEANELKESIYSQLDDFEGAPFTIQRLCELCLHPQKHYKFLGKYLRAVEKTLLVTSTWDSFPLPTAGESNRSTNATISMGITPLLSSAPPTPMFSPIPFLHDDARRSQSRSPPPSPLMLASADAGSAVTVMPQSSGDGVETKALGLVDELDDPSPGHLSDHPHPLSATTTVGSKPFLGSLEERFVRSALGGGEASGRERGSQEPDDMAVDDPEKENKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP47</accession>
    <name>A0A2R6NP47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP47"/>
    <dbReference type="STRING" id="98765.A0A2R6NP47"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR74155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="659" mass="74357" checksum="47D9F500377016A0" modified="2018-06-20" version="1">MKGLKKTLLSRSKSQESSSSKTKESKAAAAAAAAPPPPPPNSAKPLPQPSSAVASLSHLANNTSNHSLPSANGSNASLRSMTSTGSGTGIPQRAYPAPDRSTPAPPIVVVSPDVPEPIERHSLDGSVTPPRANTLSRLRTGPKDTIPIVGKPPRKQRSSRFVITEKVEIEKLPPFLETPPNERPQLFIKKLHQCAVLFDFNDANAELKGKQIKTQTLHEMLDYITTQRGVITDNIYPEVVKMFATNLFRSIPPPVNPTGDAYDPEEDEPVLELAWPHLKIVYEFFLRFVESPDFNTNLAKRYIDQTFVLNLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAPIRRSINNVFFHFIYETERHNGIAELLEILGSIINGFALPLKEEHKTFLMRVLLPLHKVKSLSMYHPQLAYCVVQFLEKDAALAEEVVLGLLKFWPKVNSPKEVMYLSEMEEVLDVIDPAEFQKIQVPLFQQLARCINSQHFQVAERALLYWNNEYIVNLMSDNLAVILPIVFPALYTNSRSHWNRTIHAMVYNALKLFMEINPDLFDEAMQQYKQRKLDERQHAVDRYDHWVKLRVKATDNSGGKLPEGFERELPTPPPPPVDEAEIMDLSIDLNAVSIEAEVPLGDLDESGIERVPMADPGMDVSFRLSILAYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPJ4</accession>
    <name>A0A2R6NPJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v9880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPJ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NPJ4"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="77"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR74372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="24929" checksum="EC259BCA4269907C" modified="2018-06-20" version="1">MSSLEKYQTELIEHGMTVGALKFGSFTLKSGRSSPYFFNAGLLASGPVLNTLCSAYASTISASLQAAAFGSAGLPEFDIIFGPAYKGIPFAAGTAMLLHRDHNIDVGFAYDRKEAKDHGEGGVMVGAPVKGKKVLVLDDVATAGTAIRGAIETVRKEGGEVVGAVLMLDRQEVGREGKSMIDEVETLVGGKGRVPTILKMKHLMTWLELHGKTQELQSMQEYWQQYGVKETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPU2</accession>
    <name>A0A2R6NPU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000980">
        <property type="protein sequence ID" value="PSR74511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPU2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11109" checksum="6302AA145F1BA060" modified="2018-06-20" version="1">MAAANPSIFNVSKAFAAIPKLHNNSTNFELWRAHVKAAAHTIGNEAILTTAHADANFDKIIAAAIQAKLQNNLFMLINALTTTSGCQKNIEIAHTYGKSEVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQS1</accession>
    <name>A0A2R6NQS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000941">
        <property type="protein sequence ID" value="PSR74958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQS1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQS1"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="730" mass="82653" checksum="E4D7ABB979BFA603" modified="2018-06-20" version="1">MPRLQHNPLKFSCDHCPRTFSTQSGLKRHVRRTHPLLPPTALIHVPLPNHDHDNNFDNSDAHLLRTENDGIVSAVAHVEHHKVLDAAPCNKEGANIPAGAEPPPQEVDDGWLPFCNRVEFELAEFLFVEEQMGQQKVDRLMDLWAATLLKHGDAPPFANHKDMHNVIDAIPLGDVPWKCFSVKYTGEIPEQPRNLLSRPDAVIRQMLENPDFAHGFDPIPRREFDARDQQVFSDFMTGNWAWRKADKLAENPNNKGAMLVPVIAGSDKTTVSVGTGQNEYYPLYLSIGNITNSVRRAHRDGLIPIAFLAIPKTGRQYDDDVAYRTFRWQLYHQSLSRIFRSLKPHMETPTVLRCPDRHYRRALYSMGPYIADYPEQALLAGIVQGWCPKCQAVNKDLDGGNPARRTCELTDVLASLYDLKVLHEKYGIHGDIVPFTNDFLGADIHELISPDLLHQIIKGTFKDHLVTWVGEYLTIKHGTPAANRIMDDIDRRIAATPPFPGLRHFYEGRRFKQWTGDDSKALMKIYLPAIAGHVPNGMVQAIAAFLDFCYLVRRSTINHDALCRIEDALDCFHKHRKIFVTTGVRQTISLPRQHSMKHYVHLIQEYGAPNGLCSSITESKHIKAVKEPWRRSNRFEALGQMLKTNSRLCKLAAARAHFKKRGMLHGTALFHALHQALPSELQEELLRQEGEVMEGNDDTVDEVAREDDDGGPVDGMKAATTVDMAKRARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR59</accession>
    <name>A0A2R6NR59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000925">
        <property type="protein sequence ID" value="PSR75129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR59"/>
    <dbReference type="OrthoDB" id="3244253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="326" mass="35563" checksum="4CF7A7C685577043" modified="2018-06-20" version="1">MSASVPSLPSPVPSNVESKPEVVSTTTIFPNATAASTSTPSSGNNRSSTIPIAAIAGGAAAGVFLAVVAVLFWHWWGRSIKRKEDRERNDAFDFLQLRENTRRNASNLVAHHYSSYRPSFSMHKHERKVAFVPSSNGPMEERSSEKEKQGTLHNRTNCLVRTSTHISTSATTASANAPETRRVVRSSVPSPLSQRGSPPEEMRLPRPLARERAVPSDPAATNRRSTIMSLEAPSLVHKSSNVSSASIYSTQSGEERQVRAPPSLIMAAFGRLDPRRPLSANYRPGSGLRHSVNMYDDYNRLSQISAGSAYLQRSDDYSDVPVGYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRT8</accession>
    <name>A0A2R6NRT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000938">
        <property type="protein sequence ID" value="PSR75056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRT8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6548" checksum="101326F82731D455" modified="2018-06-20" version="1" fragment="single">MRIWSSLMLVSNHHHLRYNIPPLLPLSLLTSSRLIHISIDDMCSMVGIEAGSDLWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRW5</accession>
    <name>A0A2R6NRW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000895">
        <property type="protein sequence ID" value="PSR75460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRW5"/>
    <dbReference type="STRING" id="98765.A0A2R6NRW5"/>
    <dbReference type="OrthoDB" id="2800239at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="383" mass="43277" checksum="1E37A42798BBA131" modified="2018-06-20" version="1">MAHGRRHFEHRGHHSHSRLTHQLHLSGQERAEFEALVLANPTAGPLELCVGPRNLKGTGKSAADIALPLLNKDRIKVERNQIRRGSKGDLKSLDASLVEFEEFCAEEDFVIQHPTIEPVSVISMQTAAMRSELIKDAPIEDDAVNGIVTDAAHGFWQESKMLLLISSSYSSVLQMWMPVLISYMNGASADHYHHHFLALFRSIRDRANACGVKLTDSLFRNVLSFSEAERGGFISAYIAFWIEEGSRRSEDDLRSAAEKLLKGCRQHFGAGVTRISRNSGIIPSEEAALFKKMALGLLDLPSVKKFQKHAKRLLKKFPKIKNWLEWWTREAHASMLFIAHRKMDPILWDELPQSTNAEEAMHAKIYAARIKSWPHWISVGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRY0</accession>
    <name>A0A2R6NRY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRY0"/>
    <dbReference type="STRING" id="98765.A0A2R6NRY0"/>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="398" mass="42876" checksum="2981778942EC80BF" modified="2018-06-20" version="1">MRAPTSTAKAVNMERPPLPFDQFNPFVKELDETAKPPAVKFQEIVRDGQATIVGRIKIPTPLGHAFILRRLDTGAISLTTMFRAAFPSANDDTERAEAAWVKLNYDVVGANKSGKARFAGTWVTPEVAMAIAASYSLESFIAPLADAVPDPNIVYRKSASAKAQQATPASSPAVPSMAAATPKEAHPTKRRREDSPSALSPAQVAAAVATTPTPAKKRAITPGATPSTRWSNSLKSPAPKLAAVTNPKRIIVRDDEEGREVLVGGDDDESYREASEVVAVAEPKMQDDIREQKELIERLKAEKAELEQKAKEAAEKVKAMTGESFPEDEDAFVGGVPTSQKRLREEASVEHKLTIKEPEAEGRAIATNSRIRVITNMPPERKQLAWGAVLFAAGIGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRY4</accession>
    <name>A0A2R6NRY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9084</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRY4"/>
    <dbReference type="STRING" id="98765.A0A2R6NRY4"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="31"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="399" mass="43529" checksum="EE74A6884D1DC290" modified="2018-06-20" version="1">MSDSTKPEETPRPTEETKETPRSTAEADFTKYKTAAEIVNATMKKLVELSVEGAKILDICLEGDKLIEQGTSAVYNKAVKGVKIPKGLAFPTSVSVNNCVAHFSPLESDVLSSQTLAKGDVVKLHVGAHIDGFAAISAETVVVGASANEPVTGRRADVIKAAYLASEAAMRIVKVGNKNWAVTDAVSKVCAVFDCKPVEGMLSCHQSQNVIDGKKRIILNPSESQKKEFETVTFLEGDVWGIDILVASTEDGKARNEDSRTTIYQKDSTITYQLKMKTSRLVFSEVQKKAGAFPFNVRCLEDENKARLGLQEAVQHALVKPYDVIYTPTGSFVAAFHFTIALLPAGPALITQAPVWYKPELVKSEKELEDPELKELITKPLREDKKKAKKAKAKTDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS19</accession>
    <name>A0A2R6NS19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS19"/>
    <dbReference type="STRING" id="98765.A0A2R6NS19"/>
    <dbReference type="OrthoDB" id="1932208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26223" checksum="00C18F11FB9813FB" modified="2018-06-20" version="1">MFDTSLCNKPSMYFVDYAYATPYAPNGRHIPENPSDGMYNFLDNPCFASIGALSGDQQSRRDDIESIAYILMYLWRDRLPWLEPQVDFQWPSADAIQNGQLSPSDASNLEYYAARYLSCKKHMVESNKIAFDQPPELQKLLNDARRLSFSGRPNYEHMIETLKKGSARIKREEKEKAKLRVAKWSESDGSDWDEDQFLCLEDGMLKSITTKVMRVKLHVRDPRDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSD2</accession>
    <name>A0A2R6NSD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSD2"/>
    <dbReference type="OrthoDB" id="3168922at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="186" mass="19895" checksum="DB91E1DA65F2E82A" modified="2018-06-20" version="1">MGTTSALRQAMSNSHASLTSVSRTAPVAQAKHRLMGTASSMALPLNDQPDIDIQIFDIFDAPSRLGESSKLLARAAGVRTVANHPARTMATSAVDRPSSTCYIKPLPSPILYDGPARPKHLAHGSHRARRAHSHAISGSLSQNDDSPFTLPSPIVFDGPSRLRPYGRDTSSEQLVSCIIFGIRITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSM4</accession>
    <name>A0A2R6NSM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear protein DGCR14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSM4"/>
    <dbReference type="STRING" id="98765.A0A2R6NSM4"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="58118" checksum="F7A6E2BECBCDA904" modified="2018-06-20" version="1">MELTTGASSSSGPAHSLNKQVILDEDEYTEALSHIIARDFFPSLVHLDATNEYLDALRTQDPQLINASVRRLEQLSTPRTTHTSYPWQTPSQTPFAAGPSDTPLRTPRGEPPQKRMRYDTDMNLDNFQARYTSEDNSSFTEILDDENRKRREKWGWAWEAQKRVEQQRDRMLEGRERLLIEAQAGTGVKERFRIEIPTPAGLLTDGSEGDRTQEGIKAQGSEIEQADGEAGKVVVREKFSRGDTEEVVDVMAPKKDTRPAGVDGWEFKARNALMFTPDADASPYHPKPAINFSGDTKPPPPRIIKYGNTRLPEQDDVPASSISAPPSPTRSRINAAITGTPYRPKSPTADDFSLVPSIPSPTPSELGPAAVKQLMTWGTLNATPRVLSQSHDPAESLEMPSSSLFQLQPPSARERISQKLSNSAAKSLRAKAELLGLPGLRTPARTKTAGFARNGSMPPPSWTPRRTEGSLTPAAKRLLDRTTLGTAAARRAEAMGVMAGWEGSSKAKEKDLNRVRWTPTPSPVTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSX5</accession>
    <name>A0A2R6NSX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSX5"/>
    <dbReference type="STRING" id="98765.A0A2R6NSX5"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="163"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="306" mass="34246" checksum="C2C90B52B5B04102" modified="2018-06-20" version="1">MPSPTPPQGFLSLVQVCDNFRVPPLSAQQTSYLTEDLVPWRLTTEPSSPVIGLLRASIVKQLVAENSKATRDEEAPWNLRQENGRTTLSFASWIDTPQKRTHIMKEMCERWRDGGLWSDIIGPKKWRGEMYPVYRNPFGKNDAPSEAELAAEGSDTRNYAFMMERSACALFGVVTYGIHMTIYEDDAESGCKIWVPVRAQTKQTWPGYLDNTVAGGIPSGLGVFESLIKEAMEEASIPEEAIREHAKAVGSVSYFFCTQDGWLQPEVEYVYDIRVPPGMEAIFQPKPLDGEVESFEVCSPIILLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT49</accession>
    <name>A0A2R6NT49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT49"/>
    <dbReference type="STRING" id="98765.A0A2R6NT49"/>
    <dbReference type="OrthoDB" id="3255291at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="819" mass="88880" checksum="0F4DBEAB4730DDAD" modified="2018-06-20" version="1">MAGRPAPTGWAGNWPPTAPAGYPGPPPPPPGVDSTRWYSGQWQFNPMFRNTAPAQAQAWAPHPSWGPSATAGANWNPYKRIPNRGDAEYWNTKLSDNPLGLENMIPIEELKKMQEQEQKLHSSAPQTPWFWVPKELKESDENPPSSREGNGTRDSQNAAYPSEHRHHHHDSHRHNSSTIATSNHTQPQQSLRQQVPQTQPPTQAPYPFYNNKPDERRAAESSVPPAVPPPSSAPASVSTFSRHHQHQENQTHTARDVRTVPTNGSSASEQARSQDADQVHAFSSHQQLQPTFSPKIVRTPMHYSGVSSASAAAAASNTSTPTRRSTRDGSTSESRTRRSSTDDSRERRSYRDDSPPPAPHNHGPIYGPATPILSRSGSGANPSSYSDLTPSRQSSLPSLSNSMSSLSVSTAPTSASSNQSLFLSSFSDEPSALLSPLLVNTPTPTTPSKTSPKEVSRSHTYPLLSSSSHTGSFPAIPEERSPTSQPPRTPARTPRPSPSEPMPRTPNSISRSRTYPTMDFTNEPPVIPTPIPSPNPLLGRAPSPSNGSRNPLPPPPHPVAYSVSSASTAAAVSYPQSHSYSRTPPQYTSSPSQSHSRSSVSNSTYSSPGRIQRQSSSRKVRYGFWNQRGDHLIVIPPPSSSHSPSSPTSALNGEQFIVYAPREHANPKELAEYPGPTQGWMNHRGQVIKYDGSVREFPDSLPSRGNPPLRPYEQFVCKPGISEASLGERLFLTNHQSISTIVIFGRAIKNEYLALATLGATGLLASVAMGGSKKEAAGPKTTLEQVKEAVKFNAGSSEEEQLMNSIKNFIAEAEKESKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT55</accession>
    <name>A0A2R6NT55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000861">
        <property type="protein sequence ID" value="PSR76123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT55"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="12277" checksum="4EEF1AF0B1B85247" modified="2018-06-20" version="1">MRNGNDVVPLKTLETVGKEPDAQDALQQFRDKYRDRAEFIEYPFDGLTSDWVPVSDSDSDSDSDSDSDSTDGQSESEGSGEESGETASASGSEDESDSDEASSRDKPGVTEPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT99</accession>
    <name>A0A2R6NT99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000851">
        <property type="protein sequence ID" value="PSR76276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT99"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="433" mass="49481" checksum="D354F4D3FBA552AF" modified="2018-06-20" version="1">MAVTTRAIPTSTLTVGTSYYEVEVLQLHTVDGLIAVGYEHGSWPNRAMLKARDCQHAVGTIPNSWGYNSNGIVNYGNPPPQWQYAPKFQGVFFEAKIYEKSVLFPSVSLSHDIDAVQANFGREPFRYAIEYIKADSLRKHRFPMAPKIPFLPSEIICVILSALASKDDKRQPYIVACSLVCRYWSKILSPYLFKTLKLRSQDDMGMLSTLTEQPNSCIPASLTRLTIHEHACSAWAHNIAMSLSHKLPNLRILQQERDHLTPSQWKTITQSTPPFVSRFLPALYSAYKGVTTFILINHHFPSFAVFTQLVSALPVLETLDCRRVTWDTRPENPRLLRAPGRLSTLQVQDCDRYWQMIQLFTARWGRSPLDWEPPLKCPEFNYNDSLLVHPLLNLNQALFPPVHDYKIKFLFACSAEERVCAYRFPLVLLRVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU71</accession>
    <name>A0A2R6NU71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU71"/>
    <dbReference type="STRING" id="98765.A0A2R6NU71"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR76708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="290" mass="33175" checksum="00EDFD3D007AF7E8" modified="2018-06-20" version="1">MVRRIATQVHKQASRLLRANYLKKEPVWYKAVLDHPPLPLPARAPSVRSAYDLPEVGTIFPSTIKHMVSRRLHPSPIYYIEDAIRRQFFQDHPFEAFRPRTLLEDAEIAPEHPISGKNWTRLRQHGRNPSSEDAVRYAVNLYEEHEVPLNDAYSSAVAQFRSLRSEHDVASTVALLEAESLGIEFGATAVEKNFKKEEMALDTWKDRPELDASERAARKRWQAIADRETGEWTRGQTYTRLWQEGVRPTYMSVPEEPTVPVDPLPSSAPANGAGQQKRNPLDFMGLENRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU86</accession>
    <name>A0A2R6NU86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCMP deaminase</fullName>
            <ecNumber evidence="3">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU86"/>
    <dbReference type="STRING" id="98765.A0A2R6NU86"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="101"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="18377" checksum="447406594FD15154" modified="2018-06-20" version="1">MAFTSYLHSRSTGFHWDRIGHGNRLSLDNFVQEHDLFFFGQRAPSVGRSNTKAAVTPSKPSFQSLNHLVNLHLMNSFESISSLYRYLEELDLSDPERLRPGWDTYFMELASLASLRSNCMKRRVGAILVRNKRILATGDDASAALFRDAGVVLRRHAPPPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWG5</accession>
    <name>A0A2R6NWG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWG5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWG5"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="246" mass="28224" checksum="81AAC8C1383E2C69" modified="2018-06-20" version="1">MSLPLPETKRVRLVSGIFPKSHVDPENQLNNLADLHPFTEQERLFTLQLDIVVPSSDVLESELKELTAKYHTRRWKLSEFVIFARPLVNGVSLDSDLIALGTPGYQDDDVWCLDTRGILSLAVKTQSYQRLGLVGKRLPWKGCDDMYIQDVLEAWDMRRESWNVLYHVSTEDVDPTTELHIVQPVVRQMKTIHLPVPMISPRPTSLDLVEEWEEEVSSLFEWVGMACLGSQRYTSPSPTHWVTDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXE1</accession>
    <name>A0A2R6NXE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXE1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9906" checksum="60C92E336C0D0B29" modified="2018-06-20" version="1">MQEIFEQRTKQKKNALAKLRHHERINEGKWRSPKLPRLLLPFWEIARYARLLSRKLSKKAKRLVDQSAAMWCLFEDRGADSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXG5</accession>
    <name>A0A2R6NXG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXG5"/>
    <dbReference type="STRING" id="98765.A0A2R6NXG5"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="58"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="288" mass="31490" checksum="545CD92F7404E090" modified="2018-06-20" version="1">MAAPVFPTLVKPSMETLPESSPLRQMFPETFYSNGNYYSSPFGRVKYWILGPADGKKIVLIHGISTPSFGFKNVAPELVKNGFQVLLYDLYARGYSEAPQVSYDPNLYITQLALLLQYIHWSNVNVVGMSMGGAVAAAFSAMFPHLVDEGVVFLAAAGMMVLPKPKQIQNQDPVAALNAQSTIDVTNQIRDLQTANLPGYQEAITSSLKGGIITGVHWAYETLGKTTDKRFLIFHGTADPTVPYGEALKIKELIPQAELVSITGAGHALVIEEGVWEDMTKKIITFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXS2</accession>
    <name>A0A2R6NXS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXS2"/>
    <dbReference type="STRING" id="98765.A0A2R6NXS2"/>
    <dbReference type="OrthoDB" id="3222645at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="459" mass="51085" checksum="6633E62246382681" modified="2018-06-20" version="1">MPASWGFLQSAFVQGILNYIPSLRKSIEPTHPESEAAVTSSPAEVEPWKEEVDRWKQLADKAAAERDQLRHEAAQLHGEMQRLVRDLSQVRTEAEENWKSHEQELRREGQEEISKREMDIQKTQEELATVKQDRADMESLLGIHIRKLETELSTAKQNHADIEGLLGTHKIELDAVQRVLGRDNVGEDEVTQLLQSLNDEIAQTAKATRELFKVDKAVRGTGKAVTDAAGAIEGWVGSAIPALLSTQYRGNPILVQAALQAMAVAFTSWISSSYSFMHEHDQVLDETYKYLMNAEDQAVLGRWRALTHKYAKQGMPNLTDELTKMLVTDVRNLLLVAGSSTGQADSLIARKRDNFRAIVELAINLRRSIGEDIISCDFETILIHPGDAFDAANMEDAFESISKSKGSGDGTTRKVLCTAGLGLRRCRKTKGEGETAGQWDVTVMRKPQVILDTVMQGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXT4</accession>
    <name>A0A2R6NXT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXT4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="8644" checksum="1D9F0E2DBE8A600A" modified="2018-06-20" version="1">MFFVSYVWRLPLATNGHDPLGQLASSAASESAAASMQSAASDASSTSTLPMGSQITIGVTSLMGVAYAYTSISYFLSLGAARGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXV1</accession>
    <name>A0A2R6NXV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v6975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000692">
        <property type="protein sequence ID" value="PSR79564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXV1"/>
    <dbReference type="STRING" id="98765.A0A2R6NXV1"/>
    <dbReference type="OrthoDB" id="2802867at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR79564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18967" checksum="8799E618BC41A67C" modified="2018-06-20" version="1">MNSLSKVDIAVTFAAIVAICLLYLYQRRNRLPYPPGPRGFPIFGNIFDIPEKRQWLTYGRWSQEFNSPILYLRVLGTHIIVVNDHETAQDLFEKRSDIYSESMTGSLILDISYGIKVKPEDDEYIEFAEKAQEGMEKSGDTSFRMRDVPFEWVKGQLVWFGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY74</accession>
    <name>A0A2R6NY74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000680">
        <property type="protein sequence ID" value="PSR79882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY74"/>
    <dbReference type="STRING" id="98765.A0A2R6NY74"/>
    <dbReference type="OrthoDB" id="3266740at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="133" mass="15379" checksum="68D2C66050956F01" modified="2018-06-20" version="1">MLLGLAIRHHRWGHRYVWTTSVTAYPWFAGRDAQTGKLPGATLPPPVSAKRSTSRSQPRGAAVAERPNHEKRPSQRSQRPPQRRPSETRRDEPTRNETPTYVYWIPHTPPEKAVTTETSRPRDKYHRDASPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY83</accession>
    <name>A0A2R6NY83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY83"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="299" mass="31982" checksum="8E690E05809593A1" modified="2018-06-20" version="1">MSPSPALIAARSSYAAALLACVTYGIYFVLAFQCALRVLNQKTLSTTKRSALLAYAVVLFLGQTLYFIGGCKWSAIEFVEAPVDPAVFAGELSSSLSMLKDVMYTMNIWIADSFIPSATGVGLLVETGKPGAVFGQATVINFGTPFWSLSVATNVIATALIAGRLLSLRRAITRLDGRDRIMLRDNTSALVICVESAALYAICAVIYIPLFAINTPIQYPFSALLGGVVVSVATDCSLKTTYLMKHPQSISPTLIMLRMASGIAINGKWGDIALRDIDQDAAVGDLDRDSKLTMDSVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY89</accession>
    <name>A0A2R6NY89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v6890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000681">
        <property type="protein sequence ID" value="PSR79844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY89"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR79844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="85188" checksum="12D9841485DEDDB0" modified="2018-06-20" version="1">MSTPSLPEKYVDPDEKQKPTVITAIADFDDPNLDLDAEGLEDDSPYPEVRSAVANTDDPSMPVNTFRAWFIGIIWAILIPGLNQFFFFRFPSVTVGGVVAQLISFPILRLWARVVPQIKVFGVSLNPGPFSVKEHVLITIMASVGSGSAYATDIIAVQRVYYNQTYNFGYQWLVVMSTQLIGFSIGGIARRFLVQPPSMIWPANLVTCALFNTLHSQQYAGIGNRGGISRERFFLYAFTGSFCWYFFPGYIFTALSFTNWVCWIAPQNVVVNQLFGTVSGLGMSLITFDWSQIAYIGSPLATPWWAEANIAAGMVFFFWIIAPALYYTNTWFAAYLPISSTHSFDNTGASYDVTRIIDGSTSFDLEKYKAYSPLFLSTTFALSYGLSFASITATLTHTFLYFRKQIWTQARLSMHEQPDIHARLMSKYAQVPEWWYGIIFVSMFIFGIVGIEAWPTQMPVWAFVLALIISFVYVIPIGMIQAITNQQVGLNVITELIIGYALPGKPIAMMMFKTWGYITMAQALSFTSDFKLGHYMKIPPRPMFWCQVVATLIAGTVQLGVQAWMFTNIPDMCNLTQEDGFTCPSTQVFGTASIIWGVIGPARQFSQGQIYYGLVFFFLIGFLAPLCQWLIQLKWPHGIIKYINWPVIFSGTGLIPPATPSNYVTWSIVGFIFNYVIRRRHFAWWTKYNYVLSAGLDAGVAVSVVIIFFTLFFPKNGTIGETTILSWWGNTVSFNTADANKTPLLPLPNGLPFGPKTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYS8</accession>
    <name>A0A2R6NYS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000645">
        <property type="protein sequence ID" value="PSR80626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYS8"/>
    <dbReference type="STRING" id="98765.A0A2R6NYS8"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="8265" checksum="1481E1187E8DC4E1" modified="2018-06-20" version="1">MSTRLDVPIKPLPQFDSEEAAKIHVPPNAQVLKLMKIEDPLLRSGYARLSLFPAATQKLYPKEFEEGREMGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZC1</accession>
    <name>A0A2R6NZC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZC1"/>
    <dbReference type="STRING" id="98765.A0A2R6NZC1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1139" mass="123188" checksum="ACC58E645F76D397" modified="2018-06-20" version="1">MTTSILPPPTFETFKFNSIGQPPKLLQRLSSAASGADFDVEMEDSSPSAPPAGATLPATPRAHRPKRIPVQVLTEPADANPEDFDSNPTRPRSYLEQITNAASSALVTQTPVFPSQLKISGTFPSQPPPLVSSGGAFVGSVRSANLRSTFPPAEVAPQQATVTGSSVTVQTSIPSSTHVPFNPPMGHIQSSLPPSHLAIADLPTFLSDLSFEHSTWSRISSLRDRLRDERQELVRRHEETVHASEREKQQAEKFVSVAEEALDIAENLGTWRCEQLDKELARRTHEEAEKVRMRDQSISQVAQPQADTSLTRDDRQQSFSQTPVINSHTAPPTTTLNTALSMAASHGETVNTQQAVQEVSSGSNSLRTQASLSRAQSVAEISALSPAAVAPSSDAPRSTTPQGSPPASLMLPMMPGAPKVPAAEQPGADVNMDAVERQQKDLDAPDQMAQKAAEEATRIKQVEEAAVRYGLEEGARIQQRQIEEAATRRKQEEEEASRREAEASQALYQARREKFQAEKAREEARRREEETRTRLEKAKSEMKLAGPSRSSPVHANTAVPVPPMSTETPVATVSQPDPSGVDAVRQEEALDKTAAVASIPDTTSAQPQKVNRGNVSGSSAVVPNMPIPPITAPLSQAFPSRGVPNPLAHLPSIPPATVVVKPAEKAKKTKPLQIKTERSPTPSIPSPLPALPSHVARNDNAEHNTSDASNRKLPSPARTPRVVNRDLLPSPALPPKPQLPPPPPRVPPKSGTKSQGTATAATRDSNNARNRGRPGHPMSAAGSKKPQPSSVATEVGAASESTPRAVIREGHPNAANRKNPRLPAETSRPDVVGQRSPVENLQRHAPREEPTVHQRVGPAYVPERNRSPAPSRGRQYDHYSPGQNPRQPPSPPVSRKRLRGDYVDDRPDRRRRYSDPDDRSTSPYRGRAPLTIVRHDYARTPSPVRPPSPPLRSPDWGRENVYTHVRINLAPSPVSTLRPPGDALSRQYVHSSAEQEYFEGSMDMDQSFGSSSNPISNANRSEQHNSSHLTQFNVTTTDQPALLSRMSNSQKSLRGRNPSGSSTGAGVSLDPGSPPRRPKSKRGGRGGATIAPRSVRGIPSIQPRTLVNRLGGSNTLDPSSHTIGIFQQNDKSKICYVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZH4</accession>
    <name>A0A2R6NZH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v6402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZH4"/>
    <dbReference type="STRING" id="98765.A0A2R6NZH4"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="216"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="363"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="531"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="713"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="935"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1094"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR81323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1236" mass="137100" checksum="447A1F4376D2ADD6" modified="2018-06-20" version="1">MATERKRKRNNETGTNGLKRRHVTSDKNKQHISDDVSEVTQIAADVFPPLVGGEDEDEGSDSGSEEEEWTGLDGAADGDVKGSEHTGSKPKKPPTGEELRNIKDATELYRSSSFKLQIDALLPNVHPKYERFAPLDRFLHSLYSFLHSIPSVEPEHPLIASRRLLKKGIAVPYSAPQPTEDTNWKVSFTKPNEVTVVGSWPTKLSVKAKDKNPYRVDVAVEMPAALFQEKDYLNGRFFHKRAYYLAVVASAIARKGGELNVDVLFDSVAGDSRLTTLVLRPKQGLKNDWSKLNVEVRIMPTLPSDCPIPLQRLSPSRSNIRTLTSEEAQEEFSTPLYNTALLLGLTPRAHLLRVYALKEAVPAFADALTLLRVWANQRGYSEGGKFCVRGFEGKGMWWAAVLDLLIHGEETSGLAKLSPKRKPLGKGLSSYQLFRAALDLFARHDFTQERVYLKSEGGHRFLPQEYNTHEAVFVDSTSSVNLLAGVPMSSLDMLKHDAKLTLETLNDGTSAAGSKDPFREVFLKDLRDLQSRFDVVMRVDLSSAKPSQPSPHATLDHGSPFNALIADLASKLRSGLSDRIKALAVLLPTSGPRSLSQAHPSNSPIIYIGLVLNTDHAFRLVDHGPPADDPNPANVQQFRDFWGDKAELRRFKDGSIVESVVWDVKNVDERAHIPFNISRYLLSRHSGIPSEDVRGWQASYDSTLRLPESIASFYQAARSATGFKTAMTAFEGLIKSIKALDDELPLAVLNISPSSESLRYTNTFVPVALPPSLSSILPACARYAPVMDVIIEFEKSGRWPDDLKAIQKIKLAFFETLATALMKSVKGLRATVVVGDGVSTSEMQDVASLEIITPDGWAFSARIWHDREAILLDKIIDDKPHIPKHLKRKLQQTSDSSGAEAKERQEAMETKALYIRRFIHAPRHHRAIAALSHRFSAFAGTVRLVKRWLASHWLLHGYISEEVVELICASIFLGSDASSKDRESVPGTKERGLAVVVEFLKDWEWENGLFVPLYGSSESEITDVTKQPSLTGGKSGAWAVSTELDPTGHMWTSNGPDAIVARRVRTIAKASWSCLQEVEDGNFDVKTLFVHPTEHYDIIMRLDPSALPRYYQNITADPSVWKGKYANAVLNGESKDALKPGFDPAQLLFNDLKRVYKDTLKIFHDPFGGNLFGAVWDPTLKESRPFRVLGGFSSTPVRKDNEKGKDKSLVVLNTDAVLSEIERLGAGLVTSITVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZM1</accession>
    <name>A0A2R6NZM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000616">
        <property type="protein sequence ID" value="PSR81501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZM1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="14756" checksum="6D38BB2D289C598B" modified="2018-06-20" version="1">MKNGLCYRIYSSTRLVANSASVSSSDPRVYVRYAFYGGYHARSSVRQKRLTGVMATQRYHFVHGSIPLEETEPWVSMDEVGMMGRRVLGMWRLSFWISPYRSCISPAAPLTHEITDLDQPLVCWVDQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZZ4</accession>
    <name>A0A2R6NZZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v6239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZZ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NZZ4"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR81867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48939" checksum="34F37717860B8C4B" modified="2018-06-20" version="1">MDRASLIGPNELSIIPKETVSNILGPKGLPRGPYYDTRKHEEGTSLDGIKEYTVHAVRRRPWARGMNSTAMKYYEGVIKEETANLIHGLRERKSKEVDISAWMSFFSFDAMGRMSFSYDLRMLKDGRDSHGLSQQIENGLIEAAWISHVQWLVPFLKYIPSASKSWEEIKAVGERLVRRRAQDGSIHPDIFYYLMNEDGQEITKPVIEVCAIDGMLAIIAGSDTSATTLSHLWYYLLSNSACFNQLRSEVDEVFPLGEDPLNDLSKLGTMSYLNACINEVLRLYPPVLAALQRRVEPDRGGVMVGDHLIPPETQVSLYAYAIHRDPSHFWPIPDQFWPDRWLSQEEYTLPSGDRIASVITDHEVFIPFSAGPMGCVGKNVAMAEMRAVVSTVVQQFDMTVANQSNLAKWEEDIREVFVTSRGTLPVVLKPRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P082</accession>
    <name>A0A2R6P082_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P082"/>
    <dbReference type="STRING" id="98765.A0A2R6P082"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="18635" checksum="710C0FD8C3C2F477" modified="2018-06-20" version="1">MFVAGVIWNLRPPKGSGKKKFLTTPADSEPSTPAVPTLAEQISYLHYARPFKNLNYTKNVNRRTKNLKAVLTQERERERLERERRRLEREEKMDVDGEPADITPEEDLPTCEFTPLLRTPSRTNQPQTRQLKRRHLCSPCANIAILQGLSVYAVIVVVLIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0J4</accession>
    <name>A0A2R6P0J4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0J4"/>
    <dbReference type="OrthoDB" id="3211970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="10973" checksum="B5BA9D2698BDB40C" modified="2018-06-20" version="1">MAQLAPAASVLGRDTPTPRSGFSPGSRGFVSACVLGTQGKRGVWVERNRGSVGRAVFGFKTGVSPENMSSADSSSLDTGEGIIHGKCLHEVQNCYDLRGEFIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1D4</accession>
    <name>A0A2R6P1D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000563">
        <property type="protein sequence ID" value="PSR83274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1D4"/>
    <dbReference type="OrthoDB" id="3225366at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="17838" checksum="A37A3C4CAC050A67" modified="2018-06-20" version="1">MEVHLLGYMNNTLQTGVGENSAMGQALLAFSYLSLFLSISAAMSSLVLTDELGEVPLRASRSKDSLRYSTYDEPSDKLLTRFNGGRCSWRWVMWHWLFNLVTGYVCIIVQLVLYVWSSEQSVGIKGAVTFIAVFSSLPLFDLFLPSSINRTISAASPGPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1T0</accession>
    <name>A0A2R6P1T0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000552">
        <property type="protein sequence ID" value="PSR83731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1T0"/>
    <dbReference type="STRING" id="98765.A0A2R6P1T0"/>
    <dbReference type="OrthoDB" id="244190at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15859">
        <property type="entry name" value="SNARE_SYN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="158"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="365" mass="40492" checksum="7EB8B0940EDE85FA" modified="2018-06-20" version="1">MATLAKLTSLSTQTLSLLLERQRLQSLGPNGSSLHLPQISRNLTQLHNGVTELEEKEGNIEAVGLLKSQYERMRNMLGPEAETSGIPRLQEATHVAVSSTSATASSSSLPLSKPSTLQPVNPPAPSFKYTDSDGPYMPYTDDPEAVIPSTDIMLQTQRRMMDEQDIHLDHLSHSINRQRDISLQINDELDVHTGLLQELDEDLDHTDSRLTRARRNLDKVAKGAKENNLNELQEKLITLHWKICTIITAMGQQSPTGSGIAKSSTKNHILPDPTTIKYAEVGGHIIKSLFSSKSKLDRYRAYLPAPSEETSRVLNLLTAQRINSVLGHWWGSNDYSLETLALGFDELLKMPGSPFTAKEKRVAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P226</accession>
    <name>A0A2R6P226_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000549">
        <property type="protein sequence ID" value="PSR83949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P226"/>
    <dbReference type="STRING" id="98765.A0A2R6P226"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="413"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR83949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="479" mass="49694" checksum="702FFA721456D788" modified="2018-06-20" version="1">MPPRNVMPGYPALQNHRTAQSIVPQPSPNFIQQRGQASFAFAGSLQQQQQQAQASTQHTPQPTLTHPSLQPQQPQAQSTPAVTSSLPPHLAQNTAPSLGTAPSVSSASEAGLDPNDFPALGSTPTSLNTPSTTNATSYASQAGTGAGAVGNGVHVGAVVGSQQRDLTADDFPALGGSAQVAQQQSSQALQNTDGHPPGLNGFQHSDQRQTLLGSLTGGGQQPGLLNLGQSRNQATFQSEAEKRNYALKLNNQSNLAAAAAAWNSPNANPSSQQQISAFPPPTNGTHPNHSQQSSGQPQTQTQHLTAPPGVPPPATFPQQQTQSAVPPQHTPYAGNGTVAGDTGILPSQSSAQVQAIAVPQTPAQQVLMSPADRWGLLGLLAMIKSADLDTNLLSVGTDLGTMGLDMQTPGSLYSTFITPWADSSAAHTVEPDFHLPACYNVTPPPPGPAKASAFSDETLFFMFYASPRDALQEIAAQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5H0</accession>
    <name>A0A2R6P5H0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5309</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5H0"/>
    <dbReference type="STRING" id="98765.A0A2R6P5H0"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="123"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR85833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="392" mass="42850" checksum="BB905A7B2F499686" modified="2018-06-20" version="1">MSTALVTSLLRAGPSRIISSVGSLHIRSLATPSSSKTNNFAKSLSEGPSLDDFIAGEVPDRVVLGNTSAPRLPSFLKTSIPTGASFKKIKKDLRGLGLHTVCEEARCPNIGDCWGGKEGATEEEGRRAATATIMLMGDTCTRGCRFCSVKTSRTPAPLDPHEPENTAEAISRWGLGYIVLTSVDRDDLADGGAHHFAETIRKIKYKAPQILVEALTGDFAGNLDQVSLVAKSGLDVYAHNVETVEELTPFVRDRRATFRQSLAVLQRAKQEGVRVTKTSIMLGVGENSDQLMDALRELRKVDVDVVTFGQYMRPTKRHMKVDRYVEPSEFDHWKKVAEDMGFLYVASGPLVRSSYKAGEFFIENVLRGKGAEKRAGTFNEENHPVTTSTTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBY0</accession>
    <name>A0A2R6PBY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBY0"/>
    <dbReference type="STRING" id="98765.A0A2R6PBY0"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR88722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="547" mass="61175" checksum="18CA03FC91AB2055" modified="2018-06-20" version="1">MGARESTARNPEEAAAVAGPPDYYALLEVEESATADEIKERAWYDNHRASFIPEPDAQTVFEDVKRGASYSRARDRGLTVRHLEQFLNPSVFTGFGDGKDGFFMLYGNLFSRLAHEESQWAEQPGETYPSFGDSTWPWLPASREETNRAARTFYNTWLNFSTSKDFSWIDQWEINDAPDRRVRRLMEKENKKARDDAKKEYNETIRDLARFIRKRDPRYKSHLAKQSEAAATKVLKGYAQSTPPKSSTPTPDISTYVEQAWQKPPSSIRDHADLEWAAAETAEDTEEWECVACGKSFRSEAAWDSHERSKKHMQAVERLKQEMLEEDEELALGLEQAELEDAEAEVSEDAQEEEPAVPDGQSEAPPPTIIDGEKEDIPEEDEPQPKPSKKKKARKSRAPSPEPLSKTERKGKMRQQLSGEVAGDIDEALRPASDTSVAGSPVGSTTPLESGGNVADKPELSKREKRRAREAAKKAKEEHTPPTKLVRPSLSVMYILLSTITQVCNVCEENFDSKTKLFSHINTTGHALASSAQGGAGGKKKGKAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC99</accession>
    <name>A0A2R6PC99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR88972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC99"/>
    <dbReference type="STRING" id="98765.A0A2R6PC99"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="290"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR88972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="505" mass="55882" checksum="DE9E1EEA313B53D9" modified="2018-06-20" version="1">MGCVGTKLGDAPVGACVPGSVAREGAYEAGLWSMGLSASTFFVGVNYRLNKLFWGRKVAVADGSPAKQIRFHKRHSFPPSLSSTTSTTTTQTMQTAVQHFAPPLLSQYTHPALHRAPNSNNSAMPTPPVPTRKRKRPHQYTVSYSEVQEVDNAGRLREVIVIEDTPPPSTVSPATTHTHLYSASYQPPVYSAPIRTRARAAAEAQALSASTSSAIPPAKKRRRDAIDIVGTVAKKQAANGHLQNIAGTTNKSWASGSGVATDDASKGTVPCDDKEGHYIIVPDDMIYRRYRTVRLLGQGTFGKVVEAVDTETNKRVAIKIIRAIPKYRDASKIEVRVLQKLKERDPLNKHKCIHLLHWFDHRNHICLVSELLGMCVYDFLKENEFAPFPRHHIQSFARQLLGSVAFLHELRLVHTDLKPENILLVHNDHKFVQVPVPGKVCEVGLDVGRDSLIVQRNAPPRIKKILESTDIRLIDFGSATFEQEYHSSVVSTRHYRAPEIILGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG57</accession>
    <name>A0A2R6PG57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="11">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v4826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG57"/>
    <dbReference type="STRING" id="98765.A0A2R6PG57"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="177"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="600"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR90677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="919" mass="103741" checksum="D9F18A67577D3ECF" modified="2018-06-20" version="1">MSIFKGSDPLSTSPRSTSRLTRSSTPSPNGSHSDLSTATDSVRPPIILGICAMDVKARSKAMREILTRLVERARGAIDVKVFGDKVILDEDVENWPRCDVLISFFSTDFPLDKAISYVKLRQPSCINDLPPQALLWDRRLVGAVLDHLGVPTPRRLEASRDGGPKVDEELRVLMKKHIGLSLGGFQVTPEVTLSEDGDSIIIDGQIMRKPFVEKPVSGEDHNVYIYFPGGHGRRLFRKVGNKSSEIDQNLNHPRTDGSYIYEEFIDVDNSEDIKVYTVGKGFTHAETRKSPVVDGVVRRNTEGKEIRFITHLSDEEKTWAAKISEGFGQMVCGFDMLRCENGKKSQIIDVNGWSFVKGNESYYGTFVRSLPYHIMVGSQLITRADKAAEILASLCIQASSSPERPIGAAEPVPVEAPTWLLKANVTVFRHADRTPKQKLKFNFPIGERWTQPFVRLLNGEKEEIILRERIQLNLIATAIEEAKGLGADGDDLTKLTQLKNALFSKIDLPGTKAQLKPVYSKKQPGQIRKLAKLTLVFKWGGEFTHSARYQSRDLGENMKKDISIMNKEVLKNVKIYTSSERRVVASAEIFAAALFDSPRDNYSTPHTPTSRSSTDGGSSVGSQTPNKKRESSQFSTTGRIPKLIVRKDLLDDSNAAKDLMDDVKKRLKILLRPGEPEKRPELTWPKSMKKEPVEVVKEVIDLLSSFREIMHRNWETMDVDKIQERWCCGDEPWLFRERWEKLFEDFCDVKQEKFDPSRVSELYDTIKYCALHHRTFLFSIFNENGQGPEEQGQPQDRRLHELYGRAKALFDLVAPQEYGIEPEEKEEIGVLTSLPLLRNVVGDLENARNNEESSLTLYFTKESHIHTLVNLVLLSGLPIANRRIPELDYCDDETDLETPMSYEAIEPLAANASDSTIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJH3</accession>
    <name>A0A2R6PJH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJH3"/>
    <dbReference type="OrthoDB" id="2755197at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR92214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47591" checksum="22258AF0344BB25E" modified="2018-06-20" version="1">MGSSFVPPELVDATIDHLHDDIPTLAACSLVHRQWLSSSRYHLFSRISFAVSKLPDFLDLIEENAQISRNVRELRVHYSQGATFGTVYNQTLLFDVLDRLPALVTLRLNGITYFPSSNRACFAPWQPPPGRTLQCLDFYGFRGSSEILTYTLSLFGKVPVGVLRVQDADMLVHPDRFGYSWDYASSQAHLFASSMVGWRVGGLELGLNRPSHHWNDLFCKILAPSCLVSLEIGALNTLFRARITAVQRLKDDYGLLFEQFGVRFAHVRLDVSTAGSLVTDILSRPVVKFSVPATVLERYLSECSSLQSLHIYCGSFRESVRDVALLIRSVPPSTKRITFGIQESLQILLQDPSFSEDQWTYLEQGLLGIRDLQYVKFVTEIADVEQTHCLLRKQIQLDHMQRQLMKEVVPKLNETGLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN25</accession>
    <name>A0A2R6PN25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN25"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="8561" checksum="49031971056C6923" modified="2018-06-20" version="1">MASHDCVVSLEGEMLYALPPSKGRGLSFTGASAYPISPSLKFNPPPDPTPSTAHPRRQNNILIAHNATYPTHGPHRTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PND1</accession>
    <name>A0A2R6PND1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v4543</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PND1"/>
    <dbReference type="STRING" id="98765.A0A2R6PND1"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR94115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="267" mass="29357" checksum="035FAEBA8A633C0B" modified="2018-06-20" version="1">MVKALCQQFSPPLLKLPPPHVQSDDECITTTYHAFPRPSVLAAPEVSNVLRSLGFGYRAAFIQRTAKMLVDAQGISTLSTVSLEPAELWLRTLRKMNTAEARVELLKFVGVGRKVADCVLLMSLDKTEVVPVDTHVHQIASKHYGLPSSKAKVNMTPALYEQVNAKLTEVWGTYAGWAHSVLFTSDLKAFSTYGLHSDASSTILPSPSPSPTKRKRKEDRPTKDTTSATLSKVSTLLLREDLPEAGLSLADRVKRRRRGQDTSSSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PND4</accession>
    <name>A0A2R6PND4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PND4"/>
    <dbReference type="STRING" id="98765.A0A2R6PND4"/>
    <dbReference type="OrthoDB" id="2804486at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14238" checksum="616C6E2D6CAA2DDF" modified="2018-06-20" version="1">MASLASILLGYRYVLFGMYPAVSPLPRAHTFCTVLFVIFNAVIASVAAWDYGMAHETGHNQQIDAYLIFLGILGVIYIIPIAAVDILRKNAVPNRVWFECLWVGVFWVLELGASAVTANASNSACSLSGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNP2</accession>
    <name>A0A2R6PNP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNP2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="109" mass="12241" checksum="CFD3F8CE16CFFDE1" modified="2018-06-20" version="1">MTEATKKSVGKFTNCGCYCDLPWIYTLAHSESFSRLPPQQVYTLISALEESIREGIITGEQVKKEFTQLKARVAESQITRHVDETSRLPVVGTGIDRAMDNLETSSNWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5E7</accession>
    <name>A0A2R6Q5E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000399">
        <property type="protein sequence ID" value="PSS02210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5E7"/>
    <dbReference type="OrthoDB" id="6511194at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="49392" checksum="185744F21CEF3032" modified="2018-06-20" version="1">MARKTRQYKACTANLQKAREQMLPEALWHPEPPSAGSPRGGTLGTSDRPTEEADVDMPSLEPWKDGMDSDSDIESEMKEEEEVSYPEDYAEFLRIAQATLAERERAWMAEYHRPKHYTGNLDRSERRHKANRNRLAVEGANFISDYFQPVSRGHYDTNASETELPDSGDGVGIYDRALSSENTPKSPVLLSITSLPVLPLPSELVSPPPVLPSPGFQVVAGPTTSEQHRKLQELLKASETDISGFSESQANWELNQYSYLQFPMLHQAQKQLTVKIKDKTLNVVYRTRITAMVATLNFYLDHDLCYSWRRASVLASKASSRSEKYARTIRSWIHQYLRSRQLPLHGYGHGRSSILDDKDFAAHWQTYLMKISKERCIFAKDIVSYITTPEMQDRLPTKLTITERTARRWLHKMDWWYSEKKNGMYIDGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBH8</accession>
    <name>A0A2R6QBH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBH8"/>
    <dbReference type="STRING" id="98765.A0A2R6QBH8"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1020" mass="117877" checksum="E996CA7917611F1C" modified="2018-06-20" version="1">MVIEVFRKEWTPWGESQLARKVEEKGGVKFVENSDTMLSELANWDAGAGAGQKETNGAGHAARLQGRTVKSSSLTLQDLKDELFEDWESAVQKNMETFEGKFALHQRQLQEELARFIREENNRLIDEVNKGPHDKIKNEELKAIWKEMDWKLNVKARLFVMTLRDHYKDKAESAAMSPFVQSPRSSQRSDDWAFEFINAKYLQPIMEAFDDDGSGYVTYQEVNEFVESRPLSLNWSLPHWVAYWAIGWQIISSRYRDRIVGLFEQMFAMRCELRPENRYWADYYLSNVWPVAFELTQSLRPANVAEHIEDKFQTYADFEEERIRKNLEDIRFDIDALDTVYVVAGPGRIEKYCFPLIYLLLKRDIEVFRIARTKVLHKEELLDSADSVLWVLKAVNYRYLDLSVLFKQNHLNVDSQMKITACGLFDYMHDSSSLWIWRNLQAIDENGSSDSSIEPNVCEWDRILNYPLQDGHSFKCSLYDTPLKQEVQADAHARMPVRAILGEWNGFVYNEDQYPAQLMTSFQAHAVPSDPLGFRASGIHDGVSFELSGRCHQGGDRTIKLTFIIRYSREYRPQYFTGYLDRSGSIVGTEGWEADECSHSNQFILKRLPARLLCYRPSPMKFEKNKARALWKYAIDVVLHEVRRHYWTWSYFSERRERRLRYIELSIRFSAYGHLPNERELVEWLIYKQSVLAVDASFYRILRDERLKIIPSHDCYCHGCGGKIGGSRLICLDCLSAEPEARTVDFCDNPECHQIVHAPNSNGDQPAKHHNPGHDVFKVRTVLHLRDVPRMSAMAGNALNVCREFFQNATPVIDTGLLATVHDNDAIRDTLASYFDEPAVQPTLSSSLTNIQCRICQHAVQQPCWFCVDCFALEEEVYICDDCETKTLLQCTHCQKPYKQPSWYYGSHPSDNFMCNTCNWNRTEAPDVVRSKQHTYLHALVRCTSKAENEDDQGPPSTDQRIMALERTVGALDGKMGRLEEALSRIERLLVTNLSTNSTQGEHSAALCARCRTFIPPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBN8</accession>
    <name>A0A2R6QBN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000366">
        <property type="protein sequence ID" value="PSS05553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBN8"/>
    <dbReference type="STRING" id="98765.A0A2R6QBN8"/>
    <dbReference type="OrthoDB" id="2803148at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="549" mass="60982" checksum="CADA796FC94AFEC4" modified="2018-06-20" version="1">MRIKNRKVLQDKTPGNTPKQEIQSQRKRHVKDIREESELLPRALTAHQQSPLKTPGSSSPARMLPVESTPLTRRHHRARMPAKGRSTRQPFSPLPPSSPPSSVVFPVRSVGREEDFVYAQENAFDEYDENVGEDKENIAASAIEHIERAESSSSDDPFGFLAVERQLKVRRDLSHHSSIGPTFKGKGIDRKARTPLGELLYEPVASSSALHQRAPTPYHPSDDLEDMYAEVAQDADKENLQPSPRRIALAALEREIDDEDDRVNFEEAEEELEETENVPALLAPPPPASDAMSDVLRTPRHSHVAKIIPLSSPFSSREGTPCDRSLPASPLSSPSPMKPLTAIRPLPLASTKKPTGATRSRQIAFMRALSSIKRPATQKKEMALSSEMTEVPTDSPTTVVRNLKEMIPERPVRRSVRASIVASATPAKPVSRADAKGKGKQKVEIVESDAEDDYEEERLSPAARKRKTKDKPQPPAKKAKMQPPPATRAPTSRRAKPASNAKTRAKGKGKDTGKVDEENSDDRRARRARIEYFKKLDGYSLQKENVYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEE6</accession>
    <name>A0A2R6QEE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000363">
        <property type="protein sequence ID" value="PSS06513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEE6"/>
    <dbReference type="STRING" id="98765.A0A2R6QEE6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015215640" description="Hydrophobin" evidence="6">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS06513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="12864" checksum="B721723BDC593C2B" modified="2018-06-20" version="1">MFARISATSLYVFIALGVLAVATPNPENAKRWGAPTTTPPVTTTITETVTAPASTVTSVSQCNTGPVQCCQSVQSASSGGIVDLLGLLGIVLQDLNVLVGLTCSPVSVIGFERVISSILTKDELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEI1</accession>
    <name>A0A2R6QEI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v3610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEI1"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="122"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="221"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS06552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="35644" checksum="65C0D36697ED1353" modified="2018-06-20" version="1">MHSSTHSMIAGAGGGLIASIATCPLDVVKTKLQAQQAISGHKSYEGVVATVKTILRHDGIRGMYRGLGPTILGYLPTWAIYFAVYDGIKNRFGEQPVGDVRVVRHVYPAAQVKGYQPLSRDHPWTLHLVSAMTAGACSTLCTNPLWVIKTRFMTQSRQEARYRHTLDAAVTIFRTEGWRAFFRGLFPSLLGITHVAVQFPLYEQLKRWAGRGNSGSLSPQQILLCSGFAKMTASIATYPHEVIRTRLQTLRKPLKGGSAHGERVPGIIQTAKNLVTNEGWRALYRGLSVNLIRTVPNSAVTMVTYEMLMRYLNSKDLEDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEL4</accession>
    <name>A0A2R6QEL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEL4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="9809" checksum="CA7D5DEB65D4BDA0" modified="2018-06-20" version="1">MDQLEEKKFAHRRGSDANAAPRPISVIHSPLAAMSITGDTHSDVGSVSGSFKLSSLPEPAMKETPAHDVFSTMHTAQQEVPGVIHGEMRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEY9</accession>
    <name>A0A2R6QEY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000351">
        <property type="protein sequence ID" value="PSS06873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEY9"/>
    <dbReference type="STRING" id="98765.A0A2R6QEY9"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14725">
        <property type="entry name" value="ZIP_Gal4-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS06873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="585" mass="64893" checksum="BF5A8A84110112D2" modified="2018-06-20" version="1">MAEKRTTVPVPSTSTLQRGKACLRCRKRKMKCDGAKPACQQCVRAKKGDGCEYDDGKGKTRTQLMREHIAKLELRIKELESTEVSSPPVTLFDPHAMSSYLSESSSSSGHGSPGNFSVSASASPIPFPLDGETPSWEDQWASMADFAAASQVPDPFSADDPPVELAQMLLEIFLPHRHQCGLEIHVGRLRESLNYPPSERRHPVLMNAIYLWACYLSRPTSLSEHESLYLARALSAMNDAVADPSKVIDLIQASCLLSVYFLSNGRLLEGSYHSSAASSLAIQWGLHQIGSSEITSGAIMNEWDSTFRLDPPKDSIEQGERILAFWQIYDLDRCWSVALQRPGMLPDNKHPRTTITTPWPQSMAEYEAGDLDIGSGSPTINAFFIHQAQATPLVGGFNPAALRVKVSALLEGANKLSQSWTPRLPTACNFQDNFRLFESTITRFITTLLPLHQLSPNMADDKYTWYMIHSLAYAAMIRLHQPFIQDDQVSRDKSLQAARSVTLVTKLLTEADFEYLDPLIGHCWVSAARIFVFELAQMPMASSWASAELRGELATLLYALSKLSTKFPLLGYEVAKMQKILDTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM27</accession>
    <name>A0A2R6QM27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000326">
        <property type="protein sequence ID" value="PSS10457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM27"/>
    <dbReference type="STRING" id="98765.A0A2R6QM27"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS10457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="35377" checksum="98F5E273B8C68C83" modified="2018-06-20" version="1">MSNPRVWVITGTSSGLGLALALHVLSHGDKVIATVRSLSRFPDSLKDLDAKPLVVDFSHSDEQVISAAHEALQIYGYVDVLVNNAANGVIGPVEELKLSDIRSQFQTNLFGIIAFTQPFVAHFRTRRTGHILNVSSIGSSVTAPGWAAYCGSKAALDSFTHALHQELKLFGVRVLSIMPGYFSTAFFANHRRDNSSEPAIDTSSRQSKIYTDPVTQGYDTTNALPRGAAERGLIGDPEKFGQRIYEVVTGTGMAEGLVARPGVDGKWEGEWQWNIVPLGTDCVNLLKSRLEHINENVATFEAISKSTEVEQEQLKYYPLGERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM33</accession>
    <name>A0A2R6QM33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000324">
        <property type="protein sequence ID" value="PSS10985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM33"/>
    <dbReference type="STRING" id="98765.A0A2R6QM33"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="71"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="177"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS10985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="75219" checksum="CEEFDA0C693DF5A3" modified="2018-06-20" version="1">MPQSPPHPEQEDAMALDGVEEALDETQPATQVDSQDVDQSWRYADNHLWGYLIPCSSHLRRLDFMKTKATYQLGRNPNRDLNNDFIFPGLKISNVHCVIKWDGRMEKGSAVTVTDLSSNGTFINGDKIGKNRFGVLKEGNELAFGSPQPQSGSYEDYRFIFRHLAGGGPNTGLYAHYELTEELGKGSFATVMKAMSKSTGQWYACKMIHVKQVRASVRVDGNGAKERIDPYAAVHKEVQILGQLRHPNICQLKEVFSDETYINIILEWVPGGDLLDYILKKDGLQEDETQHITYQLCDALAYIHRQGIAHRDLKPENVLLTTDDPPIVKVADFGLAKAIDSLTMLRTMCGTPSYLAPEVVQQDPDEGYQQIVDSWSVGVIVFSMLTNASPFIEPTNTTDVKKKILERTIDWDILQQHNLSAAGNYHVLSNIPMFNSCVGVDFIRCLLREDPKVRMTLAHAMEHPWLASFRPLRIPVPTRDPTASPTAMPLDVSMKDIPEEDMSLDGPSSSPSHNIPGAYPGGSQQDNPRALQRRRKVLDDARERGEAPPEPTPEMILRAEIEQQQDDDQHYAGHSRPLKRKARKEDSDPLTPLPEEQEEELSLEVSPGTSANGALARRGKAVAAAEGPSGSGKGEKGRGRGKAPQLDGGGEEMEEVSPAPARRSNRLGAQAPQKAARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXM8</accession>
    <name>A0A2R6QXM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000292">
        <property type="protein sequence ID" value="PSS17146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXM8"/>
    <dbReference type="STRING" id="98765.A0A2R6QXM8"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015354314" evidence="1">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS17146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="9395" checksum="DBCE9697D4D25211" modified="2018-06-20" version="1">MPVVQAFAIILALQVVYAVPAPVLQTRQAITGLSTSQISAFKPYNYYASAGYCQPAATLAWNCGANCQANPTFEPVASGGDGSSTQFCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R793</accession>
    <name>A0A2R6R793_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000272">
        <property type="protein sequence ID" value="PSS22638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R793"/>
    <dbReference type="STRING" id="98765.A0A2R6R793"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="869"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS22638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="979" mass="111041" checksum="F8C9E9F5F96A6146" modified="2018-06-20" version="1">MDIRPEYPQTPFQRAVEDLISDLSPHERSIFNMKCNNLDTMVQRVSGLNETHSRGDMRRYASKLKAIKEHLSGFFDFIRKATSEAPPYVQLAWGAFTVFLEIAATYSTRCAKLTEILHDLSEQEADVVVRYTKMGFKNWERVAKALQIKRWKGQRVFVPDGFMSRLETFNMPSYHDDLSKLNRRDTHAFIQKFNQWVDDFSGTPILWARGESRLPPWVEGIRTTADMPTFATVAGCGKTTFWYALFSLRWCPEVYICTISHSAIVNLKNRLERTELGNFVCAFFYINKSEERLVSSSVIMRSILHQLLFQAYDTIPDSEKICNFLPEGGPAPHVPDKEGLRNIAIAIVDLLPQTYILIDGADHLPNEALLDILRFIHDLTCRSKKCRAAVFSCDGQDFRNTFALYATIIECSTFARPQIAEYLKCQLRRKLESSLTAEQEKWITDNVKGSFLTVERVLDILRRGSSQENMQRRLNSIKPLENINGASEQLEYLYRESLNKIDRYSSFSEKQRALTVLKWVLLAACPLTLAELSDAVTVSEITDNDHWPTKPYMTTRDLHSLCVRLCVIHKGKVVFHHDTVGDYYIQYETSKGGGPASFKKAGHSSLYVACLRYQRLHKGGPLASYVYWHSLHHKRQAGDGIDAEDDMPFPGSYAFHGPGQSCVLKSRGNGSENADYSRQISDSSGESSVPAWFVSRADANREDVSFGQQNTTNRARDLLFATSPTSPHFHEPVSPAMPSPPRAGRLDRARKAASIMGAARFWQPKSLAQTIRPVSMPPITVEESPPSLRRFSAALEHPQNPLAHRWFFALDSDYSHNLTISELEGAFMNLNGSPNPEPFDTETVSILGKQFDTEKRGQLNLQEFTMLFDFVAACGSTFRKFDRDHNGLLDSGELLVAIEDQGFQISRIDPTMNLFLGRYGAEIPHNTEGSQVGIKLDRFARSLVALQVIKDKFKKDADKDGFIRLTQEQLLHTFLQLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7A8</accession>
    <name>A0A2R6R7A8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000272">
        <property type="protein sequence ID" value="PSS22627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6R7A8"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1481"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="921"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="789"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1395"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1410"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS22627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1739" mass="192628" checksum="BD9B8D41A24EFC57" modified="2018-06-20" version="1">MPQNDDAQRPARPRANTTFNAFNWRRGKIPTSVETAAPSAELTQPPPLETLIEALTPPAVPSLAYARGLAHTLSTVTPPPRFAILSPVLANLCGANAPIAFQAAGYDILASYWENCGSAVLTTADRLSCFSLFLDLSVSWLTELWEPRFKALVALIRSGTETVGIEAQLLKILRTWIEGAFSGLTVPDPSISPSPAHTEERLERQRAVESMTALLMSLVGRAEFVSRISETDTSTVLQLFGNLIDSALDVSSEHSGALSSPISEITLVSPTSTSRIPLRHHRHQSSLSIPQAPAVKPAADLAVEIYLNYLAIRLKAVAPVHLKTILPHLFRALAFYASPLPRLSLTPSDIHENPLEMRIMEVLDSLVTGPYSASCTVMLKYHLFPEEKGVQEAARTSLGAIRTLRASIRRVLIVHLARSYISRTTSMNYTPSGAPGQIVIERDLLERAWAKDDAATWDLNRFRSVLCRAVRQWIEFDQTGSAMCSTANHPCEMILTEITGILKDITQAFDETGDELDYEEVEAIGDILRELTAFVRLQKTPGGAPIRIALSQMEVPTNFLSMLSALLAQDLLVTPLHSVLPTAILSIAEHVSDTDTAQLLCAMLERQSFSPTSPIWLDNWKTVFAIPDLFTLHRTRTRQVAVDILLSVWEFVKDIAAYRHPLATLVFEFWREQAVDLKEDHASIIIWRILGDEIVLHSVERLEETATESDEEDPVDIAGEIVDFLTLIASESHDDELEVTGDTTLPSPSLHMPSTVGSPILSRMTSEYPSPIKERETAIPSVMSLLSSLTSGHSSRSHSQPPHSHDQPAAPESPMTHSPEQPSIPKAVGAVVALVSAFSQLAFTSLAVYESRLELATRLFKTLVSLLGGTTSTKARLAILQFFMRLRVDRDHQLYFASSDYDKEGITAALASQIGRGDKSMSAVDLHTSEEMDLRRARAREPRNGRRLSRGRGGQPSASESSRSRSRATSRAVPTSLRKQLKPLEPLWALPESLPFLISAEADTPSERLSSYDPDGPENKIVLPLSLYLAQLVSIIRSGKDWELLSYVLCHLPAQLSNKHLFCGPKSKVVLNDLLTTLCSEILDGRVAASVERWPENVFPRDAQGLAYHTLTILVSYKRCFEKNIHLLHTLVEVFLAGLSGSSHTIKCCLNALSLSAFELPVSMTKYMSRILEKLSQIMSNPAMAVHIIDFLAIVGSQPALHSNFTEADYKMVFGVALQYLQHHNRPEASLTISWALSQHVCIMSYYIVYLWFLAVKLPDRPRHIKYITRQLLLANEGRQEVDEPTEVCFDWLARYTYASADPRPANSMLSDIIMSPLPSEASSQPAIAEKTWLLGNAVVTIRTLAKRGWVEVISRRASGLTKFLCRAENVPMVTAGDVDPDLLSVAATLTMDRGSGSEASSASVSGTSEEIKHTAENSEDHEPPDPITGYVWSGTAPSQRRKEVSIDPSYFALQLSSYPNSRPSTIGRIVADSSRVPAFFRALDRMPVIDTHKVGILYVAPGQSDEKDILGNTHGSPAYTRFLEGLGRLIDLRGQVDVYAGGLDPDEDGEYAYAWWDDIGQILYHTATLMPSGDEDKYTNKKRHIGNDFVRIVWNDSGQPYRFDTLSTQFQFVNIVIEPHSRGAIAAFSHNIHENEYFKLTLQRAPGMPEFTPVGEFKLVSAETLPLLVRQLSLLTDWFVAVYQHTQNDTAQVEMTTNWRSRLQAIKRFRSQLAVPTVPERLEGILGQESFRDFTTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIH3</accession>
    <name>A0A2R6RIH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000253">
        <property type="protein sequence ID" value="PSS29819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIH3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="168" mass="17717" checksum="1180D12520AA5095" modified="2018-06-20" version="1" fragment="single">PKASSSSSTTTQPIASSSTIRAVPTSTTPKPQAPRPTQIPIAHSASGSGTPIQQPIAQQQQPPPPPPPPSPPPPTTVVPMAAQNPSLSDVSKAFLAVPELRNNGTNFELWRASRQQLVPLGTKLFSPPRILMPISMESSRQLSKGSCRIIYSCSSIHSLPAKVSWTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM55</accession>
    <name>A0A2R6RM55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000219">
        <property type="protein sequence ID" value="PSS31110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM55"/>
    <dbReference type="STRING" id="98765.A0A2R6RM55"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS31110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="588" mass="66138" checksum="B9E4994EA37C43D8" modified="2018-06-20" version="1">MDPPATSQPQVRLQMDPEEVQHIDKKPRLGFATEENDAIHEYDDHDPESSKEAMEGLTSVFDQSRVKRSRPQKKLTKKMKNMVIEPYSAQDVIFRDVISLLGQEAVDKAIQEGKDWESPFQFREEVELTASILSSTGESLAIAPAPYPPWVVLIPFALPGETVRVRIHRNCKMYSHAELLEMITPNTEMRDDSLIRCKYFGQCAGCQYQMLSYETQLDLKQEVLVKAYQNFSDLPQELIPAISPTMGSPLQYSYRTKLTPHFDRLPKAKMADTVLDGSRPDWFKIGFNGSGTRSVIDIEECPIAAPAINEGFGPLRERIYKRLYTYKQGVSLVLRESLPTGTRPRSHSPSFGLRPQIPMGRLEVAETTSDTEKKVCVTDQRATVRERVGDTIFEYPASAFFQNNNSILVPFTSYIRDMILPEGTSPQSKVTHLVDAYCGNGLFALTLASSFKRVAGIELDVSAIQWANRNAQMNKVSEDKVSFLAGHAANIFETVQDFPRDKTAVIIDPPRRGSDEKFIEQLILFGSQTVVYVSCNAHTQARDIGMIIKQSEALKRGNKYVLDSVRGFDLFPQTAHVESIAVLRLVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPQ8</accession>
    <name>A0A2R6RPQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPQ8"/>
    <dbReference type="STRING" id="98765.A0A2R6RPQ8"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanine nucleotide-binding protein-like 3 N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="270"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS32011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="659" mass="71701" checksum="4EF476D9FB4C83B9" modified="2018-06-20" version="1">MPRIRKKTSNRGTTSRREEIKHKVSETRKKRKKAAKKNPQWKSKHTKDPGIPNNFPYKDQILAEVAEERRQAVEAKQLRKELKKAAKAGAETKGEESEQEGSEAGYDGVTAIHGIKAASGSKNKKEVTVVEENGDNEAPGLINPEWPSLKAVLDAADIVIEVLDARDPLAYRNAHVEQLVKENDSQNLLFILNKIDASPREAVSAWATTLRSHHPTLLFRSASAYLPSSDVTPTKGKGKERADDALGLESVLSILRKRAEEKVGDESLVVAIVGLANSGKSAFVNSLVGKASAPIYRLSSTQDGPSTTLHSQEVVLTIGDKTIRLIDTPGLSRIQSDECSEEEISRSRAHDILVRNKGRIDRLKDPEPVVNEIVTRATREDLMLFYNLPAFAEKDTTAFLSALARANGMIKKGGVLDTVGASRIVLRDWSTGKFPRYATPGPTSLATPADPTSELYTKDEETLSKLPTRKELRKSSGVVKLTPSEVDDRRIALEVTWASADDDESESDGAEGREVELEESGGDEEEDEDEDEEEEDGDEDEKDEDEEEEETTLPVGKRKRGITKASEPVRPAKKVAFSVEPQNTKQARAAAGARGSALAAARKAKAGLKASAAKDKSATPKPSLKAAAPKKVANAASSKKAVPVASSVGEEAYDFKKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVL3</accession>
    <name>A0A2R6RVL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVL3"/>
    <dbReference type="OrthoDB" id="3256736at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF4">
        <property type="entry name" value="PROTEIN DIAPHANOUS HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="678" mass="74399" checksum="ECAF6ACFACC91915" modified="2018-06-20" version="1">MPGSLFPRSPSLEPESTPYKDGGHQTPSSRDTRTPRQPSYRNLLEEAEKLVSTPNPFLVEGPPQTTGVISFSNDGPQSLNEFNPSPRSSPSPVSPRRRPSTPESPVGSDHARNQSATPKGKERARKTVYDFLQGDTSQEIRVRGKEKELDEAREEQLRKEQELDPDASAYFEERERDKERIKSLEEEVARLKSQLAHQRHRNGSGPTPPPPPPPPPPPLPPPRRTLITPLTVSNIRKRSGPFTTAATESFLVSARAALRKQGPPVEAPINAANAPRTVKSTRTAHPTVKMPTEKMEAFLTEMKSVKLRKVSGVLAPPLIPDETERTALARSVRSSNGRDVLRDMVRRKSMSQLDPRTGEKRKRDITDAEFIVPTIPAKRIAKEGSGVSDTSSSSFTSSSSSIFSDRPTLTLADLHNRTWPSISTTDTDITTPSLCSDNENDPTSEVSPEDVLPPTPPRNRRSPDAFDFSIVEEDRLPEIIDVDAEPDDGDLSYIPPPLRDSTPAPPAIENAFARRVPVSPLPLAIPKKPRPPGRVRRTQPLPGTGLESKDHGSSNTSSRIPTLQRVAKKRKNKKASDTGQQPKQTSSGQIRVIDLTAHPSAHARRRRTLDHELRRAGDHLWHSDDFDDLESGTLLGVGTKDNHGGFLARGGGGGSPVFMGVGYVEGAEDLDDNRPSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVW9</accession>
    <name>A0A2R6RVW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHLCEN_2v1776</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVW9"/>
    <dbReference type="STRING" id="98765.A0A2R6RVW9"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="20">
        <location>
            <begin position="121"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="20">
        <location>
            <begin position="435"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PSS34159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="564" mass="61439" checksum="3FF96776D36BD30C" modified="2018-06-20" version="1">MNTAASYLSAVSYADARARAYGKTPGSTPVLSSSSSMTSASEDTVLHENEDNEDGLSYANGYAPLNSDFDSFYTRRFKLRIDDCFSHPVTGVPGRTIVLLDRYSPDHNNTMISTGTRTRALNVSSYNYLGFAQGKGACAEAVVESVERYGLSACGTRLEGGTLDLHVQAESIVSRFLGMEATLVSSMGFATNSTIIPALVGKGCLVISDELNHASIRVGIRLSGANVRTFKHNNMKSLASLLREVISQGQPKSHRAWKKILVIVEGLYSMEGTLVNLPAIIELKKKYKFYLFVDEAHSVGALGPHGRGVTDYYGVNPRSVDILMGTFTKSFGAAGGYVSGNKSLIDRLRISGHSGTYTEAMAPPVLTQVIASMASIMGITLPQKHSPSSRSSLHNSENAALGVEYESYPGRVPAAALPSWMTLTPSMCDGSDSRMRLRRLAFNTRYLNRALRKLGFITYGHDDSPVVPLLLFHLGKMATFSRLMRTRATPIIVVVVSYPATPLVTSRVRFCMSASHTKEDVDTVLKACDEIGELLDLKQAEGERWPLQEIMDRAVELVNMDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW29</accession>
    <name>A0A2R6RW29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000140">
        <property type="protein sequence ID" value="PSS34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW29"/>
    <dbReference type="STRING" id="98765.A0A2R6RW29"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="170"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="495" mass="53194" checksum="947A3D3C985EC7E7" modified="2018-06-20" version="1">MVEASNWRSASEKGKSAKVKDTRVRAGTNQDGFGWSCDGGRERVSPSPSPPNSLDDACVFAIMPGNKDSATYSASVNPPRRAKRQRIEAGSAAATAAAASSTSGTSPAATSQRLRPHNILPKDFALIDKSADNGTSDEEEDEYDPVVSAPAPKRRGRKPLPMSRSARESQRKLNHSRIEKARRTKINETLTTLSNLVNEAEKQRASAPGGSKPAIDVQQPKEKEKGGEKEFKLDVLVKTVTYIQELIEKVKTLEARKCSHCQSSGESRRTSFPTPAPSMSPPMKRKRPAEDAEETIEVISDDEDPRIVDTHTGRIEKASRDTPRHPGPSPSLPPISAWLPHPYIDPSCIAAMSDANPPPSSSHLPTPPLSGSLRTPVSLSSQALPALTLPGPAHPMSLEESSQSMRISMPSRRLSNARSPTVSPSWTPEDETAASLLLQMSSSPASSVSGSIPGSTPKMQARSLETTWSNARWARQRGDVRAETPSSLLGLGTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZG3</accession>
    <name>A0A2R6RZG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZG3"/>
    <dbReference type="OrthoDB" id="2687259at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6143" checksum="2E72F83F474910F7" modified="2018-06-20" version="1">MADGEDDYGYNEPGPGEESEDEDGGNEEITEEDLGPEDGEDDVGEEGLEYEEGFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3T1</accession>
    <name>A0A2R6S3T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3T1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="223" mass="23984" checksum="ABAB34953B6EEA8E" modified="2018-06-20" version="1">MAMGKQVAPPKDAYSQTPTQGKEDLVLPLEVTEELKKLNSVMIEKDALIEELLKENTALRNKMSALESSLALHKQEEPTAVLGDHAHSSVFSDDLTLVGGNFDVSLSGELPQLEDTTVATPPESYPEPPSPVRSNDSMSSPRLISPNESAFSPDSACDSRSESGNPGNLFRVLLPGSRCHIFTGSARAMRSVRLVVPPLEDAEKGPPFDASSEFSSDEDDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S485</accession>
    <name>A0A2R6S485_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S485"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1499" mass="166246" checksum="5AE0D0A06ED5B56D" modified="2018-06-20" version="1">MPYNDGGYWEAARSQSVRYIGEQASIYSQNFTSWDNRYPGVPSFQTSPFAQSIFQHTAPSTVYPTPPPGISSSSSSLANALGEPPQRPAPRAYRPQDSARFFNDFLAQQTTEQMPTPVAKEQQDLKPLIPSKLATDSSPNTRALVPTTPHTSRKRKAAQVLDSPSVKRVQTPQQASMLARSQSSVESRSTPSTSRGTPTPRNKLQAYVEVPPIPKVYQTPSQKIENWSSPTPTHRNKGKMRAHNDDDLGGFGSEVDDPHTMSMKSSGRRATGERDDRAPLEKLIALLEDITEAEDSLSPDADLSELSSEFFSSLTFEASRPLLHANIIRKLCAHITKVARPSKRTRQNTRDSGSRSPIKSRGTMLDVDTNLLSRILRTLERTVKAGEDIDPFGSSRSSSLGANKISEVGSPKKSPKKKHARTDDRRSKSKTPRPMEDDNEHREESTPGPEVPTDADLDALTRSLELAKESIYAADCCIALLSSDKLTKQLYSEELITTCLSTVKNQLMKIIYPFVEASSDVYSQVPPLLRYTVQSLACDCSAQRRQLAETFHAISSAIPRINDLICSESLAMPEGIIIQAVYVAIGPFFVVESGIDGKGKEKKDSVVLSTLGSSAMRGLRLDALSLIRSIFANHEDQRSWIIEEILSSLIKLSDSKQKAGQFRLRDGRSIRTVSALLLQLVQTSAHDIRIEARAIRKSRQQALVLQRQESFDERSQEPFLDEKDMEELRLYSSGLDSAMKAARTIVAFLTQRSGKTKSTKNSNEAEYRTIFDNLIADLLTVLFWPEWPASSLLLSIAIKYMVSSLDDIKSNTSENNAAKTIALDHLGIIASRLRNSSLRSINLGNQHGSRLKPIDEVSSALDVQGLELLMAAHQDLSSYLCKRAADDRAYNSACELTAVVWGQELSSVLKHCAKLLEDGVTAEATVRPFGTKLKSALQDVWKDSSADIFDSSNLQEESLRIDRLAEEIGTVQTLKVYFNPILNVVLQALDAPPVFMRTKALKALGQILTSDPTILGTENVRRSIESHLLDSSPAVRDAAVELIGKYMIESPELASNYYQKIAERVADTGLGVRKRVIRLLKSFYIITEDRERRIDICVRMVLRMLDEDDTIKDLAIRTMEELWFLESAGPDIAQKPFSSPTDTTNLLTKVTVIMGVSSNFRDRHSPLEELLHKIISEKDGANATSLHRRYAEICETLIDGLVDASDIPGFTVVNCVRTIYLFSAAYPAVLSTSNVCTLLPYLKNATTPEEQIASDYLLRIFKASIPHLPKTALKFGQELQLALQPMIVKPSTTAGVVGLQETVACMCTVVRHITHDFKRLVSLLKSCSGRLQQTLAKPISAKTHATDMRTLSILILIAALLCEHCDFEQLKTQDDICTELASVTQGSVTEHMYHTFLRLYEKYSDSHLRSRILQCLGFLFRTQPTLLTAETSSHIMDDIFASEDEEARGRLLKIMQEFLVSEAEKHAAKEKVPSKAKLPADNVNMDELVGNTDGFADSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5B3</accession>
    <name>A0A2R6S5B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ran guanine nucleotide release factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000044">
        <property type="protein sequence ID" value="PSS37409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5B3"/>
    <dbReference type="STRING" id="98765.A0A2R6S5B3"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19004" checksum="4DE6B98F7C5B3210" modified="2018-06-20" version="1">MSSTKDLFGGAIKVTLPNNYIDASTLRQIPDTQEVFLHPSSGVSLIVEVLESVDQQDIKKAAEFHFDSLAHDNSAVKHDVGQVVTTSERRGETPAPVLLRGTQLVPKFNKTVPDEVQILLALYRIPSKNVDLVMTMNVPTRTVEGGAVSGDELAAATREFDIAAPSLTIADFGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5G6</accession>
    <name>A0A2R6S5G6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000039">
        <property type="protein sequence ID" value="PSS37531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5G6"/>
    <dbReference type="STRING" id="98765.A0A2R6S5G6"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="3">
        <location>
            <begin position="109"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="616" mass="70061" checksum="0E3D1B89331E067D" modified="2018-06-20" version="1">MSETSPLLSTSPRNSFEDFHSLPTQDYYHPNSTIGGSDKNNGWAVPRKQPAKSNGSAFGPDTKLNCNALNEADNRMWIPAENPEKHCGHQHRTLVLCFDGTGDQFDESAGLGTYTDPLIKTPVASKVSMVLDQMLAWNLDSHVKDGYTFLMENYTHGDKICIFGFSRGAYTARALAGMLQKVGLLPVCNHQQVPFAYEMYKREDIKGLELCHDFKETYARTVTVEFLGVWDTVASVGLVPRYLPFVHENTGVRYLRHALALDERRVKFIPQFCANTEPKLESKAEHAGSETQLTSNGQQTMKRDAQNHGRPKPVHQESTTRSFENSINRQNGIKPDVQEVWFAGVHCDVGGGAVDNDIVHKLARIPLRWMIRACFDCNTGIMFEACKLQKAGLPVYVGDTGKPVLAPTYQWQPSPPVTPSLIRPKRTQSMLPLVIAALFSPFVLIGTLWRAVFGTKTEETQLPPRDAHQCNLEAISDYYEYNQDMEDIQMPLNDQLEKKALWIFLDWFPQRVKKFKAIQKKTDDWKSYKWVLNRGKGRKIPRSETKPDANGDPQWLVHRTVKMRLDVSLEEPYVPQARPNIPITLKGSNGEHLEDPRRMTHEEWNVEDPQHWKWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5N7</accession>
    <name>A0A2R6S5N7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial presequence protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5N7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5N7"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="202"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="820"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117372" checksum="3D7BE75C8EFE8EDD" modified="2018-06-20" version="1">MPSVQTNGENFGNFDLITRTKLDYADILVSKWKSRVTGLSIVHLDYDAPLVNGYFVVGTEIFNDSGCPHTLEHLVFMGSEKYPYKGIIDHLANRGFSNGTNAWTDNDHTAYTVSTAGEQGFLQLLPIYVDHILYPTLTNAGFVTEVHHINGKGENSGVVYSEMQGRENTSGDIMALQMQRLTFPEGSAYRSETGGLMQALRKLTVEQIREYHHSYYVPQNFTLIVAGKLASGTQSLLNVVQTQVEPSLIAHGQNQGPRPAGWKKPFVETPSANRPAFSETIKETVEFPEKDESVGEIQISWVGPPPNAFLETKAIDMLGIYLTSSSASPLNKEFVEIESPLCTYIYFEEREAATRGSLNVYIGSVPTEHLDTFDEKLRCSLQRVVKEGVDMDRMAMLIDRDERQLRSKVESSKGDTFSGNVITDALYGAENGADLGPSLEEIPRLDELRKWTNEDWVNLLDKYYIKPHRVVLIGKPSAAMVQRLEEEEKARISEQQEALGESGLKKAEEELEAAKKEHEKEIPTEILKSFPVPDVKSIVWIPVQSLQEVGSSTERKKTVDPTTNNSLARHIEADGSSLPFFVAYDHVKSDFVCVHAYFSLANLPNHLRSHVTVYLSSLFSLPVTRSTGEHLSHEEVVNKLDNDTVQYDAGLGMSSGFSEILRISIKVENAKYETAIAWLKDLVYGIQFDKDRLQVTIAKLQQSLPEMKRDGNTVMSSVAANLLYDESSTSRAGAVLTQMEFIPEISKRLQESPEAVIAEFEEIRKHITEPSGVRFSVTGNVLDLKEPRSTWGKHFKQHLKESSLAPVPVAADTLSKIGKKPAKKAIIVSLPTVESSFVSYHAKGLQGFTHKDYPALRVAAEILNATESYLWRYIRGSGLAYGAYVTLDLEAGLSGFSLYRSSNSTEAFKQAKDVIHGLVHGTITLDETALDAAKSSIVYSVAKGVSTPGRAALVSFSNQALKGVSQNYNIEILEKYQAVTKEDVIYALREYYLPVFDPSSSVAVVVTAPSKAKELGDDLTMAGYEVEQRTLHIDPDEEGEESDSEMDTDEDDESDDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Z2</accession>
    <name>A0A2R6S6Z2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Z2"/>
    <dbReference type="STRING" id="98765.A0A2R6S6Z2"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="205"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS38047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="37895" checksum="B779826E5B359864" modified="2018-06-20" version="1">MSHTPAEIVAQLPERFDKARESGDVLFFPSTISKHQAHGVEFEIRLCPALQKKPSLPTPHFDANADERRAILGKEGKKFDPFAPPYVPGLYLGDVKDEEEGVEYAVLFNKYAVVPHHILLITKEFHSQTSPLMPPDLVQTYLLLVAAHNAGRRFFAFYNCGDLSGASQPHKHLQLIPIEDNGPPVEVLARRTVIETLERPFSLQSLPYANHVRRFPAFLPTAPVDEIEPTLSRAFLSLLDLALSTYRRDPAPSTSATTMSTLSYNVILTLEHMHVIPRKAENYTLAETGDALSINSMGFAGCMLVKSERELEAVIKEGVGEILRGVGCKSIHDQQCEGACSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U7KUH7</accession>
    <name>A0A1U7KUH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001120">
        <property type="protein sequence ID" value="PSR72984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U7KUH7"/>
    <dbReference type="OrthoDB" id="2799721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="357" mass="39515" checksum="F3D4AFEE92E80104" modified="2017-05-10" version="1">MSVIQTDPVLDMFNTTLPAEIEAVSGMEAQNSSTAVEVSDDQDASEILPTPSVLRTTAQCNKRPADDLTECAEQAGRRVRLKPANIKELVRVAKFSTEERGIYQLAFLMKIDESLKLINFSEMTHWSISALLTYKIELYTFTVIASPSLSSYVTDGYPTQLVMGVLERHPVWGYTKEVREDPLKKKIVLNKVMTRLTDRRAKIKGVIIESLGAIHPLDPSKNRQPRDILELCQDIAGLAGGSLDEDKFKVTLQMCARVALFRSVLTTTYAHAIQTALAKRQAVPSFWSTVDKSLDGIRARCNNNATLLSQGFKAILDKDLDTYGQAPVSDYSGVEITPSQQVSEGAVRGRAIMEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE17</accession>
    <name>A0A2R6NE17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE17"/>
    <dbReference type="STRING" id="98765.A0A2R6NE17"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="98"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="615" mass="67834" checksum="CBB5CDEF48BE216C" modified="2018-06-20" version="1">MFSFRRRTAKKQVNNGPPFIRTSPSLPDLSAEGVQWPESLIDVSELPPATETLRSHGKRAQNPEGGPISSLYMSHPPSAFDNRKSTYRNRPSQRKNRNPPTFNIMVAGAQGTGKTSLLRLLLETADMSPTATAEQKTAMHLFLRGPPKRTDSIQSATVEICESKYDRILLSVVDTPGLDFQEGHELKLERQVSSIVKYLDTQFAETLSEESKVVRQSKGDQHVHLCIYTIDPASIITPAERRSLSSFPTTTRSEATISPPELTTASDDSLSDESEDELGEDISVSPIDIAVMKRLAKKSNLLPVISHADCLTDDKLTAIKNVVRRDLDAAGLDFGVFGPINSGANKREKDANGNGNGHGVKADGVNGSANGDSHNEEDDATEEPEEERQSRPVIKLKQSRNPFKLRFNSRSRSRLDLTDSANEPATAEITDNESVASIRFSAHIVSKVGLSDILPFTVIAPDYNPRRTRVRQLSQLSQFVPDDRQSIHTDTGTSAVSPSDDGHGPGSIVHSPVSPTLGATRNLAFLSGPPADLRGVFVRKFRWGTVDVLSPEHCDFAALRTAVLSTHMKMLKVRTKEVLYEKFRTEKLLARRATRNISEDDTRRMFEGPYSQCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEA5</accession>
    <name>A0A2R6NEA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001348">
        <property type="protein sequence ID" value="PSR70578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEA5"/>
    <dbReference type="STRING" id="98765.A0A2R6NEA5"/>
    <dbReference type="OrthoDB" id="2657661at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="470" mass="53198" checksum="3BAB49168BC9FF1B" modified="2018-06-20" version="1">MSTIWTWLHGSSTGTSERAKLSNASDSEITPLRTRAEPISQIDPLHSRLHLQPVTPEKVMQWRYEQSFYKDHFVDGSDSTGVELVLEIHQGEPEDGKTDLICGYYYADWERRVVFWQDDIHIVDITKGQRPLASMSHLDLVTSETSTAPYDLETIKEFVEIVHKIPASDESSTNIGNEGYEEGAGRDMIAIADGMFLNYHGQYCARLNRDQSVHSGGPKEKRLSAFFCLVSPILFYTPDSYMKKLDMVWVDDTLNHYRWKEFITRVREEWERYNTPATVMLTTNVAFLAIQSIDTDHADNARSFAQIASYASTLLSLACYTIYHVLILRFPHAHNRSLVKVSTYLKRRELGWLGLESLALVFSLPTSLFMWSMIAFLVAMSYAVFVGTDVYTKTLVGILLGILLAVTFSVVGITWQGGGRIPARENQWVEFFSSLKTQLVKRPPTEKDSGAPMTFWTGRSSPVSGSTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NED7</accession>
    <name>A0A2R6NED7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001346">
        <property type="protein sequence ID" value="PSR70608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NED7"/>
    <dbReference type="STRING" id="98765.A0A2R6NED7"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="237" mass="26618" checksum="3C77051A9C4FB064" modified="2018-06-20" version="1">MNPTWPPFTDGSQNFDNVLRSLLDSLSVLSPELIPIHERLVNIRRQLVALAAKETASQAALAAKAAEEAELRTGIKPSYFDEDSPGADRESKTPTKDMPNPEPIVAPKLKAELKPLQEELRKIDSKRIDGKFMGPGGTFPASQAVCSSLLEDCFDIVQEIRAQDESKNVASSLKPIYDRLTEIRRELENLVLTHRWSLRETDLWNYSLSLQEIDKMRIDGKFVDAEGNRPVGQYVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEF3</accession>
    <name>A0A2R6NEF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001334">
        <property type="protein sequence ID" value="PSR70711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEF3"/>
    <dbReference type="OrthoDB" id="2754177at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="299" mass="33883" checksum="36825669903E663D" modified="2018-06-20" version="1">MVDSNSNVDCDGYIALHHMLSPSLTNSISTPESSSFPAMNLTYEETRPTLYHFPHLRIDVRRLVRKRDGLWPLLPPNHPFSLYPSVELMIPDSLDLYDFGRIWNKFPRLRFLSLTWELQRDTITIIDDFAYDFVPSYIVKTVETLNIHLRCGYKECLTPKRFVKLLDLLPNVTCLRINVFVFLKDIAPHLPSLKVLILDAPPFYAGRQYPGNIMGWNVAAGLRAGLFHGLDGTSPARIIIESGRDKPLGWGPAAKACARCGVEFEHRVIYDASGKVTFPEPPNHSFLKVAISQSTSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEJ1</accession>
    <name>A0A2R6NEJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001318">
        <property type="protein sequence ID" value="PSR70793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEJ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6233" checksum="76843EE19611D7DE" modified="2018-06-20" version="1">MGEDLDHGGPVEEVEAEAENYSGSIQAEEGAAPEEIIEVHPSSMDPTPSTSQFPVLHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEX9</accession>
    <name>A0A2R6NEX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001300">
        <property type="protein sequence ID" value="PSR70944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEX9"/>
    <dbReference type="STRING" id="98765.A0A2R6NEX9"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11761" checksum="FF87934260E7D0D5" modified="2018-06-20" version="1">MSYRRQHLLSADGTKIWAECAGNPSKPAVVFLHGLTSGLFVFDRQFSDENLLKDLYMIRYDLRGHGQSDYPATPTAYESRRYAEDFDAVCKWAEANKPVVLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF04</accession>
    <name>A0A2R6NF04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF04"/>
    <dbReference type="STRING" id="98765.A0A2R6NF04"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10752" checksum="EB69BF025CFCBB85" modified="2018-06-20" version="1">MLGSAGLPKGPGMAGRNLHQPILPLIAIMDPIEHARRRKPWNRAFSTAALKEYQPIVTRRTAQLIEGLMGEVGTTDLAKWISYYAYVVIYPPLFTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFJ2</accession>
    <name>A0A2R6NFJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFJ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NFJ2"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="269" mass="29665" checksum="472267F088D78791" modified="2018-06-20" version="1">MSRSYDRALTVFSPDGHLFQVEYALEAVRKGTCAVGVRGKDVVVLGVEKKSVLQLQDPRTVRKVVMLDDHICLAFAGLTADGRVLIDKARVECQSHRLTVEDPVTVEYITRHIATIQQKYTQSGGVRPFGISTLIVGFDPHSPRPRLYQTEPSGIYSEWKANAIGRSSKTVREFLEKNHKDDLSRDDAIKLTVKSLLEVVQTGAKNIEISVMESYGKVTSLDLAQIEAIVSDIEREKEAEAERKRSRLAATAAGQAAMSQRVAGSEAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFK0</accession>
    <name>A0A2R6NFK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFK0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="7795" checksum="8DCE56058A7674EA" modified="2018-06-20" version="1">MNTSLKYSHGRKGETLECVRTVVKVVLGHLKGPQTMPQVKSYGTPEKERLKEPSCTSPEVPSGTTAPRNGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG04</accession>
    <name>A0A2R6NG04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG04"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="13812" checksum="508F346C692C7A1C" modified="2018-06-20" version="1">MNRDDLATIQDLTNPLSAAEEDLSSFLFALANIIADELENLGVDIASLRHSSPQDTTQPESRDSDTNSAGVGILVDEQREGILPVESIPLATLSTSMPSGAYPYRDMSFGQHKSVYRIFIHRCKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGL9</accession>
    <name>A0A2R6NGL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001281">
        <property type="protein sequence ID" value="PSR71491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGL9"/>
    <dbReference type="STRING" id="98765.A0A2R6NGL9"/>
    <dbReference type="OrthoDB" id="2742161at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="197"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="632" mass="70790" checksum="A28E099D1EB69E5C" modified="2018-06-20" version="1">MAGETTLSRMPKSLPRKGWLPSISCLTSSSSKGGGARRKIVFNPWAALRGNTIPPSLPSTPVPRQSDPGPSQDVTIGQSQAMPETDEGQDSQSLPRFAGKKARINNTIKPSTRSVKFLTHWAKRALNAMLRGEAGPSNGLHCAQCRARSLDVVYRCTICFHPPTLCSRCTVSTHRLGPLHVVEEWVVERGYWMRRTLGELGLVFELGHGGERCAKTLSSTRPMTVVDSHGLQNVHVRFCGCLVDNGSAIPDAIQLLEAGLWPASWDLPRTAFSLQVLREYHLLAMQAHTNALDFFNVIKRLTDDISPEEADDRYREFLTATREYFFLNLCRRKGVVPEFGMEAASLATLCPACPQIGINMDPDRGSREVDKRFLDALFHAVDGNFTQNQKDKKMDADDFPLTLGAAYFANESDVSLFMEGLPPYKPEHSTCNKFGAMGFGVHWGNVSGTLGLSCARHTFVLPGGGVDLQKGERFANVDFCMLSGLQRWMDLPVHVSAYDINCQYRINFAERMKTFRGLTTEFKSIRRKFFPWTIAGVGKFHLYAHIFACRYKYSFNFLPGVGMTDGECVERIWSALNGLGLRTREMASGHRHDTINYFYDDMNVRKTQTLSNTGYLWGFLAKIKLENRLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGQ2</accession>
    <name>A0A2R6NGQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001277">
        <property type="protein sequence ID" value="PSR71499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGQ2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="166" mass="18004" checksum="97B5356CCE4D8C3D" modified="2018-06-20" version="1">MAAPQIGANDNAAILLNYEPTVRAQDRLNDLAPAALLPADNFHPGQMMPESVYGVFMADDSEVEYSELNSESAAEVDDLLQITRRFDGMSVAESPLEVSPAAIPPRNLLKRTSTEAGNNYEAPTKKTKILPQRVQGNKARLRKRPEAAVTPSRVFLAPLAGPLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGQ6</accession>
    <name>A0A2R6NGQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001266">
        <property type="protein sequence ID" value="PSR71575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGQ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NGQ6"/>
    <dbReference type="OrthoDB" id="1743579at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015322611" evidence="1">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="36737" checksum="E33540A1C420D79F" modified="2018-06-20" version="1">MAAWALTCLLLLTGRAFASANAMSTIGSLHAPCLCTFGAVPVPVNVQIPSDPSEGLNTTNLRRLKKTFNIFGEFCQPSGQQLVINGQTTFSYDELGVGLSERPLNSTDIQIPVAASVASSLAAQLKDGTLTSSLGLEKQLFKKVVGIAHSQGSVVFNFIAITQGASTTLDAMILTGHIHDQGFLATFDDPKPLASQVDPARWGNLDSGFITTPNRSSFYSPDTSTFSPDVFMLDGLTKDVSTIWYTRELPSVYVPAKGFTGPVVELVGSMDQLHCLNAVDKNLPCNSTVLQQMEAPFWPDSRNFTALVREGSGHDVNLDFGAAETFALYSSLVEVMTRQISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGX8</accession>
    <name>A0A2R6NGX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001279">
        <property type="protein sequence ID" value="PSR71498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGX8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGX8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="34"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR71498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="453" mass="51711" checksum="AD4320F5C7DBADBE" modified="2018-06-20" version="1" fragment="single">FYLARWGEAYEDSKASRSDQNWHWHWHWPWERLPSPNQDVVPWLMIYFYLSTAGAFSVLAYISLGYYASLQASRTLFDAMLTRLAAAPTRFFDVTPIGRILNRWTSDINTVDGKLQSSFRTALYGSLNFIASFTVIICVIPSFSLFAVVIAWLYIRLAPSYIRASRDLRRLESVWLSPAFSGFDELLRGLPHVRAFGMEKRYQDGFYKKVDKFQSFDHVYWLVTTWLRWRYDCLGSVVVFSTMVFALWSGIGDGLAALVIVQAEIFAEASRQLVTVLAQLELDFNSVERIIEYLDVPQEAPSMIEERRPPAYWPSNSGELSVNNLEVKYAPDLPSVLHQVSFIIRRSEKIGVTIISQDVSLFSGTIRSNLDPFAEYTDRECWEVLERCHLTSVLNRSGENNPNVPLDTLISQLGCLSAGERQLVALARAVLRRSSVIIMDEATSQIDMDLDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHV7</accession>
    <name>A0A2R6NHV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHV7"/>
    <dbReference type="STRING" id="98765.A0A2R6NHV7"/>
    <dbReference type="OrthoDB" id="2804180at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="364" mass="41397" checksum="3994343C5B1042EC" modified="2018-06-20" version="1">MVNAYTQKDIKEEREVEEMLEPPCNLPFDGPCRPTMHRTIVDYVMDEEQVHEMLCEKTNLLSDEITSVGDMETSESNPAENNRIPLDTHRLGQNHASSSPSKRSRRRKIPRPNGGFGINYGLKEMLNWPQPRYVKLLTVARNLSNKFLDGTRPFNQQNATRVQYAVREGAQILPELAGYEYHWPMADALAVYVNNAWYHRRVVNRQQVDCSPLASSSGSSTLRNSSTDTSDLHADGSQTARFSSVSPHVSISPPSSGNLSRRGRRLVPQPIGTPGLPGRAGYNLKTTLKWGNEEYDELWDLVRSLVKEHHLDESKPISLQAPRRIEAVIKGCLEEMPRLKWYENCWPVRDVIARLLKKTSYKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIB9</accession>
    <name>A0A2R6NIB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001214">
        <property type="protein sequence ID" value="PSR72109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIB9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIB9"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="396"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="279"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR72109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="720" mass="80553" checksum="18777B1B12F0FABA" modified="2018-06-20" version="1">MTNVPSGSKRPWAGGNDSDTRKRARDDSRDWRDVHLSSPRGKPLSEGRDSADRRRNDYHAHSRDHDHRRSSDHGRDRRDERDRRRDRSRDRERDRERDYYSRRDDSRREDGGRRSRSRSGGPRHSNGHVNGHAPVTKDESEKEEGEISPRPSPTHNPPLKSTPVLPSSIPPAPVTELELDLPVPPPSVEETLAARRAKRQAILAKYAGTTSITTSQTASPSPGPSSVVEPPPVSSVSDAPSQPYSVPATPGVSSASAYASKRESISVSPTPALFALAKEGQEEDVQVKAQEEEGNREQISAADYDPSLDRREDEQKRVRGVPEETSADIEMVEEEEEDDVEDMFAVVTAEKKKVKRVKRVMKPSAPALITTTLDSAADPEGYYQVILGEQLDGARYQVFSSLGKGMFANVVKARVLHGEVGEAGKEVAIKIIRCQESMYRAGQKEVQILNKLKQADPDDKKHIVRLERTFEHRGHLCLVFESMSMNLRDVVKRFGKDVGLNIRAVRAYAHQLFLAMGLLKKCNIMHADIKPDNILVNEQKTLLKLCDLGSASDASENDITPYLVSRFYRAPEIILGVPYDPALDIWSIGCTLYELYTGKILFPGRSNNQMLLLMMELKGRFNTKMIKKAKFGDVFFDDLGAFQSVEMDRVTGSDVVRKVHITKPSRDLRARLMPSASAKLKDDESKLLTSFVDLLDKCLALDPAKRITPKEALVHPFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIF3</accession>
    <name>A0A2R6NIF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIF3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7784" checksum="16D7D8F87E1C6975" modified="2018-06-20" version="1">MSGVLETVKHAYPSYRPDARYACTRNGHSSCLRVRTVLQMVKDLNCTPKVRLTCDEDCYDLKGVQSCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIK9</accession>
    <name>A0A2R6NIK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIK9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIK9"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="27753" checksum="788D09182B195AA3" modified="2018-06-20" version="1">MHESDAEKENRAEKEDDNDASTEGRSDEVKGRGDVRDIAEMDKRVGELEKIIGSSNTALDEMSPLPPPLLPLLTRLNTQFTLLTQPRHIDNISRRLKLLLSDLDRLSSSNGQHQGSGQRRQTGVHPGSSAHPGSPVVPTPPQPTTHQEQLAPILTRLAPLLPHIPHILTRLRTLSMLHTNAAAFQSSIEGLEEEQRKVRAALVELESAVEGVEQSLKDNENVVRNNVKDLEERVDSVWKRVEELKLNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ28</accession>
    <name>A0A2R6NJ28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ28"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ28"/>
    <dbReference type="OrthoDB" id="3257007at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="674" mass="76834" checksum="20B4424F3651C980" modified="2018-06-20" version="1">MEYRPYALDPSVGPQTSSQDGVEETHILHDLMAGSNDHSGRSRDSGLNTGRAEPLQRNLHPSAELYPDAHHNSAQQILEDIGTQIIGDITRRLDGFRLEFQQDIRDVKQEIQDIRSGMESRSSRSAFVDQDGDWNILTEDVGFDGDTENNPVRRSAIGRIYTRAQGGASRRPSSNSQDGQRRPTTSPQPLRNQIPNPEVQRDRTYHSNPSQPRQQPNNMFNNPGRSDAPSIAFASSFRRDSRPPSDIGHPESVQPTYGTPTSPLRTYVQNQGPSERRVPRRFMTSRGGQLQGERPHADAEPRQFAEQGLGPVPQTSPQESLRAGTHQSHRPLGGRPGSDGGRNYADAALPQYSRSGGNRASDRRGPRNARREAGPHRGPDDEGWDTEEPENLLATLLPKRRPDWRNECLKDCREAMRILMRREEGDSAFNLNLVPSPEEVAAYRSSQGRCCTDDNFRLDLNGTPKNDWNKSCYRVFERYFLEMRYACTDTKEIEKAFFSHVKYLQDLWRKEVLSQHELEARQQAKTRFHRKQALMERRVSAALSRNDTVAHALILRRLGAEGMSSDESDHENGVAQYRILIHPWRHPHLTPWIRTFDALHRRTRFAPVMHNTRGAHPRNRFPSAIRSNSQRPAPPGLPINAYNPEWYNRLAEWDQEDLRADEPYEFSHTATTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJY5</accession>
    <name>A0A2R6NJY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJY5"/>
    <dbReference type="STRING" id="98765.A0A2R6NJY5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="121" mass="12995" checksum="42E8C34D58D98DC5" modified="2018-06-20" version="1">MTDFLARESELLGDEFSTPTETGGSFATAAGDDIDFDHAISAFPDIEFDGDIPVPSAPSGAPVVSSGSFSFDDFDTPPIRGRDTDVKVTGDDEIEKFENEFPELDMPSVSATCTQIYVEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKC0</accession>
    <name>A0A2R6NKC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001138">
        <property type="protein sequence ID" value="PSR72751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKC0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="262" mass="28735" checksum="07411986690A35EA" modified="2018-06-20" version="1" fragment="single">MDVKNKSSPWTFVMKVHLSRKFKRKCAYVRRKVELSTGRAIKDAIEKYDQENADSGTTEASNKGTSESARKNQPTCLNVHDGQSAQCPSTPLRGYHVRLKLSDPQDRPTQIDVSCGGIDLHVCNGQCSCTSGHQTTDPMMPAQGVSQTFNNRAGKAPDTSVLSSSDVESILSKFHSSPLLSRDEGYIVKERSSIITQSTLAEDDTRTETIPMDGEDTEAGTDWDGDSDYQSAYSIELYSVHSEGGPPAERLEHLVMHTGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLV8</accession>
    <name>A0A2R6NLV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001082">
        <property type="protein sequence ID" value="PSR73344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLV8"/>
    <dbReference type="STRING" id="98765.A0A2R6NLV8"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="432"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="474"/>
            <end position="475"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="567" mass="61761" checksum="610686F4BB836059" modified="2018-06-20" version="1">MLPLTKEGIYPGLPVYAEVPRRSHQLGLRHVLLTLLAASATAYVLLGSLYRPNEFEVYTCGSPSCARNPAFLVKAKHGAVASENELCSDIGVKTLKKGGNAVDAAISTTLCIGVTNMFSSGIGGGGFMTVRLPPLQSNLSSISSSKVMTIDFREVAPAASREKMYVGQSDKARWGGLAVGVPGELRGLKKAHELWGKLKWSDLVRPNAELAKGWKVSKELERRIEMFATPMHNLPEWKAIFAPNGCLLREGDIISRTALSRTLETIASEGPDAFYEGPIAESILARIRGTGGIMTQDDLSNYEVKVQPALEGTYRGRKIYTTHAPTSGPVLLHMLNLLEKYEDFAADGRTSLNVHRLIEIIKYPNFMERADAKHIDEIPTKAYADYIFPNITDGFTHSPEYYNPVYDVPTDHGTSHSSVLDKDGMAVAITSTVNLIFGSMVLDPVTGVILNDESAGPTQFCKDNYPQPGKRPLSSMTPTIVEDEAGDFSIAVGASGGSRIFPAVFQVLANLEWGLDASAAVEYGRVHDQLFPTFVDVDNVYPSEIVEDLKNRGHNITSTYMQGLVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM58</accession>
    <name>A0A2R6NM58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetylornithine transaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM58"/>
    <dbReference type="STRING" id="98765.A0A2R6NM58"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39891" checksum="A40CFEA461260E31" modified="2018-06-20" version="1">MADESRQLLHTSNVFHHQWAGKLAELMVTLTQKEGGLGWPAGTSGRKNAKVFFANSGTEANEGALKTARKVGKMRWAAKHGKQWDDPSCDKIELVCFENAFHGRSMGALSVTTNPKYQKPFAPLLPGVKVGQLNSKEAIEDLVSEKTCAVIVEPVQGEGGIHLADENWLRALRKRCDETGAVLIFDEIQCGLYRTGTLWAHSALPADCHPDIITMAKPLANGYPIGAVMIRDIVAEAMTAGTHGTTFGGSPLACALGYHVLSRLSAREFVANMQETSAYLQGRLSQLPKWFPDTLQPSVRGRGLILGLGFRNVDHPGRVVTMARERGVLILTAGKDAVRLVPSLNITREEVDVAVDVLESCLGVLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMJ5</accession>
    <name>A0A2R6NMJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear GTPase SLIP-GC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMJ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NMJ5"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="297"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="4">
        <location>
            <begin position="903"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="128226" checksum="2C8CC7576E3AE94D" modified="2018-06-20" version="1">MDFKENLHLSISPNEPRIKPEPQETHITPLVENKAWRSTLGESKVATKLEIGDAARVYLDRGLPVPNYLNGASGSSTIASRVKDEDVDMKDAPHALSNPIQPTVLEPAVKPFTVYQSEDDITYVPEDALKQGLGMVKSMKHNIKRLELGSKLPCTAVVTEIGYHPKKTIDADVSFLSEAEWRQELAVLLDDLVDEDGKLKRSTDLRSDAGVAWQKVHAVYPAVSQEQIIKLTVDQILSRDPSSSFPFFVPLYSLIRSTGVAQILGTTKHITAKDSKAFAQEIGKYIDSKDQKRGDKKEKNAKEKKDKDKGKSIIEKLREQNNKRMGTGTGSQDKNHDLEEPAFWPLIRQVQVQCNAGALSTGAILVDLPGVADANAARNNIAKDYMKKCDCIWILAPITRAVDDKTARDLMGDAFKMQLMTTKCDDVSCSEVIRALNLDDDPALVEIEDEIDACNTEMDEHKGKKKEAESTAKEIEQGLKQLREFFAEYQDHLKAMENGETFVPKLTAKTKAGKNAEDSGSRGKKRKNSRGGKKGSPKRRKNEKSSDDEDEDDDFLVDDDDDLDFSGSESDKNSGESDDDKSEFGSNKDSGDEEDDEEDQEAEEATEESLKEKIEEAKNGIKEFRVHLSEARKLRKEAMDALAGLKKRQNKAQREKNAFCSLKRSEFSRDVLKEDFRIGLKDLDDAAAEQRDPDSFDPTLNIRNYEEIDLPVFTCSSRDYVRLKGQVKGDGDPACFTKFEDTGIPELQKWCHQLTVSSRERAARNFMTHLKTFATSVKGYVQGIGDVTVADRDALREKWESILPDDDDDDEADPFGGFGGGWASSDDPFDLPGLADLANPLGNAFYTMQNKAPKVDRFGELVGITPRLVKDFMKVIDDCVHELQKSFRDGLEEKCRVGAINAAAAALETSDNFAASMHWGTYRATLRRHGSWRQDLNVELSNPFTRQIASSWSKVFEADLFSGFEKATKEAIKNVLKEVEESAALGLKERAKGQAEQALEEARVALEKTLGLVRDTINTEQKEVSRCLAPHIRNQLVDDYNAAMAERGKGSVARQKALFHDAISDTKSEMFDGAADVIMGRLAKAAEAVGKALEGSLSELAETVEVSVAVLWEGVKDDPAQVKVRTEVISSVAEIIEQIRLWQEAARQKQTTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN98</accession>
    <name>A0A2R6NN98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001053">
        <property type="protein sequence ID" value="PSR73869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN98"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="683" mass="76058" checksum="B026E980ECA35B73" modified="2018-06-20" version="1" fragment="single">STPPKTLPLTPPGPAFASSSTSAPGIPGKPENKSPPAGTKRPRNSLDSRDEASKDDSGSGIKRKTLDYSETHGRADAKVQSGGYALEAAACTYGTRSSCLGIVLDNDVMSLWYYDAAGYVSVNQCLSLLADFEKVVAIFVGFACLGHERWGAIPSVISPPTSAPYPTNFPPESLNDHSFVLPRRLNSKQMVRVTLTEPCFTQYNLVGRRTFLYDIKTDTVISKKPLVVKLSYQVVTRKREDQLLTRAKKAKVGHLPEFHLWGDLWNMSDGIRQIFYETSSRLSEDERGVATYEDRTLRALVYTKYLPLKTLFSESCELIPVMVDQILDCLHDLRYKANILHRDVSCNNIMYDIRRGKVHFILIDYDLATVVTDDGEPSAVASSKHRTGTLPFMAYELLLDMHNNSIDSNSPRVMHYLRHDYESLLYVSLWCAVYIPPAANDEQREIFITYLQTWETGTIQAVGHAKEALFSHNIGSLPLPPSAAFLRPFFTYWIALFAEAYIKSVVLRNKAAKAMTKSQGPQLHTYNLETFNGLITRDAIKQELAEAMAPPEPSDDKEGLLPVGDAEPVLGDLANAQMNVDREDGHTEATLPEETCTVETAKSIVLPIPDKTPALAKATVATRRQKTDQAEARTRTTRKVNTARVMEEVVPPKKASVPKNPRIPKASTRVTRSMTTRSMVRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNH9</accession>
    <name>A0A2R6NNH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001037">
        <property type="protein sequence ID" value="PSR73981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNH9"/>
    <dbReference type="STRING" id="98765.A0A2R6NNH9"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="9843" checksum="5A841B0A49B0F2B5" modified="2018-06-20" version="1">MEEAGQAPGEADMAGQSKYKQIMGLKSVHFLACWALIYVGVEVTLGGWIVTFIEQKRGGGATAGYISSGFFGGLMLGRISLMWLNRKVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNK4</accession>
    <name>A0A2R6NNK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNK4"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="45566" checksum="E5A885D66C3E3761" modified="2018-06-20" version="1">MALQVNLPQEMIDAIIDHLHDDKTALSKCALVSPAWLPSAHHHLFHTLRVLVPRESGFTSFFQFIVSSSPSVCESIVVFELGGPGSSFGDLETFSELDLDAFRSVLSRMPNLTSLSLHGLHVRSPFGSSSHTISSKLSTRPLTGLKKLVLTNIALKDDNLRDLSGLVALSSGLEELHILTLLDRVATLSADWMQTAKVVQQAEDMRLKTLSFGSPFMTMPIVVRILDSIPTLGSSLTSLDVRAVSSDDLPPVGKVLGVVGPNLRYLGLDISYLHTGNHSIRDLLELPHKCDLGSVTHWDEFNLRRCTSLQEIRIQASMYSPWETVTKELLSLTLSHLFSAVQTLHLILDVHPLMHISKLEDGILPFPGIKTVKVLTHPQAGSPPFRGRGLDISERVFVVHELPRLNSRGILRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQL0</accession>
    <name>A0A2R6NQL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000951">
        <property type="protein sequence ID" value="PSR74867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQL0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="255" mass="28435" checksum="25A30A7C1C997B6A" modified="2018-06-20" version="1">MVTSRRHDYQGMGGMLIDLTAWMLNALQQRLDEKYNKMLCRIIKKKTIANAVGDAVGAVFGEMLQEMELKHGQRIVFEKGGSEGMGEYERYRRNRTCDALGYVIPNATIRLLGEIGEGASATVWKGKVGSKVVVVKVSKLGRKRDVVREWKGVEAIMEKHQALPIPRYYGCFESVNGQTAAIVMEMCGEPVSRSEGEDEIPAAYREKVAAAVEAFRVAGVEIYDHANRNTLVTREGEIRLIDFALDVDRDMTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRS5</accession>
    <name>A0A2R6NRS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000889">
        <property type="protein sequence ID" value="PSR75497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRS5"/>
    <dbReference type="STRING" id="98765.A0A2R6NRS5"/>
    <dbReference type="OrthoDB" id="3227343at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="158" mass="17369" checksum="8D21373D6420B955" modified="2018-06-20" version="1">MKKWRVDLLGVPFTVFSDHRTLENFTKQKHLSHRQAQWQELMSQYDYVITYIAGVDNAPADSMLRKPLPPCTITSDTITAIWEATTAMANHPPVTPVLAAMSGLQIDCDANWITAVKSGYELDSWCSYLVDSLWDSVAQKAIGVDAAGVSASKALGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRU0</accession>
    <name>A0A2R6NRU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRU0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="8019" checksum="EDA5CBEEB1148026" modified="2018-06-20" version="1">MGGHAATQSMGRANAQRLREEREEKNAPQESFLEMQRISIHGSADDLSAHVSSHGSKNTASGRLFPIEEYHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSM0</accession>
    <name>A0A2R6NSM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSM0"/>
    <dbReference type="STRING" id="98765.A0A2R6NSM0"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="64001" checksum="2811FF68DC2757BC" modified="2018-06-20" version="1">MKIDWDKVDHPEVVFDRFPSRRSVVFGTKGIVSASQPLAVEAGLEILRKGGNAADAAVATSAALNVTEPCSCGIGGDAFCLFYDAKTKTVKALNGSGRSPRKLTIEHVRQQGITGNSIPASNLNSVTVPGAAAAWVDTVDKLGNGKLSLSEILAPAIRLAEEGAPVSEITGFSWMRSEKLLQTASPNGDEMLINGKAPRPGQVMKLPNLAKTFRSLAEHGKAGYYKGRIAEAIVELIQSKGGVMDLEDLASHDTDFVEPIQYTFNEEVTVYECPPNGQGITALLALGILDNIGEQGKIKSLLEMEHNSAEYLHVLVESLRLAFADSQYYVTDPAVHHIPLEELLSKEYLASRAKLFDPTKVNPNIVHGNPVNSSDTVYFTVADQWGNACSYIQSNYAGFGTGAIPAGCGFTLQNRGSNFNLTPGHPNALEGSKRPYHTIIPAMALKGKELFLSYGVMGGFMQPQGHVQVLLNMLRGFTAQAALDAPRFCISAGSPETQNTQTGAAGDINSEVYFEEGITEDAVDKLRGKRYFFATVLPFVDGYVSEAMGHDARRASGFARGMLGRGQIIQQVVDPSGVRVWVAGSDPRADGHAAAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NST0</accession>
    <name>A0A2R6NST0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v8745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000868">
        <property type="protein sequence ID" value="PSR76004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NST0"/>
    <dbReference type="STRING" id="98765.A0A2R6NST0"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="114"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR76004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="225" mass="25003" checksum="6B44862C13EC9B7A" modified="2018-06-20" version="1">MASSANTNTASPNARTNGRHSSEASPESHPFKNSTSLLEVIPQGIDIEEESRLYDELCNSPLPDTAFDFEYSDNFPNDDHPRTRNRPPSVFSAEDAPSIWLADNSNSGSSTGFARDVHIAGWTHVGDKLGGAYIVYDCAITTKEGTVMHTHKRYSAFAQLYAHLRATLPAAQQRFVPPLPPKNPLSKFRATFLDRRRRALQHWLASVLLHPDVGGCEAVRQWVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTV7</accession>
    <name>A0A2R6NTV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucose receptor Git3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTV7"/>
    <dbReference type="STRING" id="98765.A0A2R6NTV7"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28681" checksum="EC4AD9144E1C4C4C" modified="2018-06-20" version="1">MRNNPSFIWRIVTICTGWSAVAFVVASGPLLVQSEAKGPYFGPSGYWCWITDNYPREQTFLEYFFEWLSAGFSFIIYIAILLRVRGNLVRGKDGWHIRYVPRSQRWQLAISRDWLDSTMMQVAARMVWYPVSYSILLIPISLSRLVEFGGGNVPFWATILSDTLFNLQGFVNAILLFTTHRLIPDPATLPAFSTRKAVDLSSSAALGITPFVLSPVPPSQTVSPPVARISNDFHDINLASPASFDSQTPLIREKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU04</accession>
    <name>A0A2R6NU04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000851">
        <property type="protein sequence ID" value="PSR76274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU04"/>
    <dbReference type="OrthoDB" id="2804335at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35446" checksum="CD6C5BBF3335A064" modified="2018-06-20" version="1">MPATAADLPPDLFKNILDCLQTSSRSPYHGENSIVAVTKHELAACSLTCSYWATACRPRIFTHITLRSREDVYTLLSFIEQPNSPLPGYIKFIRISSVLSGLPQPWIYLVPLLSSPKLNPFIDKELYISQPLDSDGKDRVVDLNLHLALPSSVPSTPFIDFSDIALTDIHLNTYSDLSRFVRTTPFLGWLRCERIAWTTAQEETLLPGSSRTSYITYVTMEKCTENWKAMDLLLGATYLMFHLPGSFMEGRHPNGRQYRRLLLDVTERLSVVALVRSIQSVIDSEQSLQPYVSTSAEPFTGEQHFYISKIEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU36</accession>
    <name>A0A2R6NU36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v8265</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU36"/>
    <dbReference type="STRING" id="98765.A0A2R6NU36"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR76668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="464" mass="52024" checksum="DD7DCC95989ECA1B" modified="2018-06-20" version="1">MVDSEDEDGAGSSTLPLILAITSLVWYFIILSMGLLGCWTARKRYRLRPRSPLASADPASIPGVSILRPLKGLDANLYENLESTFTQEYSNYEIFLSVESEHDQALPVVKELIAKYPHVKAHMVIGAENVGSNPKVNNLIRAYRQATYDILWVLDSNVMVDRGTLARSVDVLDGPQTAAAPSGRRRIALVHHVPFAFATEQTLGSHIEQAFLNTNHAKMYLAINTVAIDSCVVGKSNLYRKSDLERVDGTLKPVTPTSGDRSQQRGLAAFGRFLAEDNMIASALWKELDLRHELSCDVARNAVGSMSLADYFWRRVRWIRVRKHMVFAATLVEPFTESVVAGVLASLGLRYLLGLPPWLFIPLHFLTWLSIDLDVYASLAAHPIPSGATFWKFLGAWSLREGMALPIWLYAIWGSTVDWRGKTYVVMRNGEVKRASRDARGWFRRIFGTKERGQEYEPLELAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV87</accession>
    <name>A0A2R6NV87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV87"/>
    <dbReference type="STRING" id="98765.A0A2R6NV87"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="476" mass="50228" checksum="762D85C425545602" modified="2018-06-20" version="1">MSSVLKTEPSPEVATMPVAVKVKSAKSSSGTSKPKSAKVKSSSKSQKTTTSAESKPKVASDSSKAKAPSDPSKPKTSSDPSKPKKPPSTKPKTITDPAKPTGHKPKTTDSSRPKKISTPSSTKASKDKATSKGSVAQTAYGDIDAFSNLMTSAGEHIHSAQGIVDQATGLTEASVRLAQGVQHLLATFDSDDDSDHPTRHSKTTVTVAHQHSSHGGTVTHASQISNRAIVAPHAAVDVHRQPRAPAQPVGSINKMSTYVAESPSVTHSDEEAGGHPGSVALIYNETGVQLAEQGGEDEDEEPHFETEDRSEEGAGEDDDANGSDNDEHAGHPHDDESDDEVASRTSDEDETGTEDEDQKSEDNDGEEEEQEGTDDEDNDDGQRQDDTDDEQGNDSDDAPGGHMAADGSSDDEDEIGHGRKGKDMNNEVEDNASDSNGDKGDAVDNDDGRAEDGEETNSKGFATRRNESDEDDDSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVK2</accession>
    <name>A0A2R6NVK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v7800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVK2"/>
    <dbReference type="STRING" id="98765.A0A2R6NVK2"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="109"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="248"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR77610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="750" mass="83811" checksum="03F75271522DE88E" modified="2018-06-20" version="1">MLTSPTSPPPKYQTSSPRPHNPLSIRLYKVLAANLDDDTTKEALHTLADLYAPSLLNDTKVKPQDRELKGDRERLNDIDDEDDDTKEDANTKLPAQSPALAETVPGEIAARARRNLKKDVESKLAESSRRFLTAFAEVDKQLDTLQEYIGAMRLRCDDAQSQLGETNEACKALLDRAGSLREQRQEISTRQSMVMVFLSRFTLTPEDVEAITSREVPVGKRFFNAMNKAERIRNDCRVLMAGEEGPTKAGLDIMSTTSGYLEEAYEKIFRWCSFAFREMGRDAQIDVSPAMREAVRRLRQRPELLTEALGTLSQTRQATLLNNFTTALTRGGPGGLPRPIELHAHDPLRYVGDMLAWVHQAIAAEREFLEGLFGARAEEGGRMVGAVRAYGGTEEEDWMSELMDTAVGGLCTPLMIRVQQTIRSQESSITAYKIANLLQFYMLTMQRTLGEEAALSKRLREMTDYAYKAFSDAVEAQGRSILGIHLDLDDLTLTPPFAILDHTQILREILTVYESSLGDESSLRGKSAKDVNEAAAQGCRAILDQMVDPAVEMCVLASEEKHRLRPSWDREIFIINVLTYLQSVLEPYSFTAEKRDVIQDLVAGRVVQLIEDHFTGLLVDTGLGEMVDAGKARQGDEPLSHLPAASSSRLQAALHKFSVWLTSNTVDYPPRLGQLSVQSLASRVHRAALARLVRTYKWLCEEVRNPENKYEAAATVLGSERPFGQVHLLWQIFGIDEEETGDDIVTDKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVU8</accession>
    <name>A0A2R6NVU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000769">
        <property type="protein sequence ID" value="PSR77885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVU8"/>
    <dbReference type="STRING" id="98765.A0A2R6NVU8"/>
    <dbReference type="OrthoDB" id="2797179at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="365" mass="40852" checksum="9D5ABA70053A370D" modified="2018-06-20" version="1">MSSTGDNVDVFTKPEADVIVRSSDEIEFRVHKFILSTASCIFADTFSVPQPESFKVVDDELDDEGGEDGEDDLPIVALTEDAETLRVILRTLYADGISTIEDLGLLARVLAAAEKYEMAGIISTLAPFLHTTRFLESEPLRVFAIAYHFTLTEAILMAAKATLLHPSPSSLPPELECLPTHVYHKLLLYRTRCEATIESTLVDWMSVWIGFEEPPADAPHAFWQRVQAGAMDRPVWSTVDKGGCLFCVRSTYITLNKYGVVPLWFIDHLERTRDMFKDRIEGPTVKSLKLLEKTISILPGIGSNGGCECAARAPLQLMQFSERLSDKLDEKLAEGKKHASDEGDENLKHVRKNKRDESASRRDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWL5</accession>
    <name>A0A2R6NWL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="12">ITPase</shortName>
            <shortName evidence="12">Inosine triphosphatase</shortName>
            <ecNumber evidence="12">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="12">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v7447</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWL5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWL5"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="20520" checksum="780A17A893273ECF" modified="2018-06-20" version="1">MASTPLVFVTGNAMKLQEARAILLDAKVEITSQDLDVPELQGTTQEIAREKCRRAAEILQGPCITEDTALCFEALNGLPGPYIKSFLKELGLDGLNTLLTGFPTNAAHALCTFAYSAGPGTEPILFEGRTDGKIVPPRGAGKFGWNPIFEVDGTGKTFAEMTEPEKNSISHRYRALEKLTVFLRSQTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXE8</accession>
    <name>A0A2R6NXE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXE8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="12011" checksum="0C09D731474C4845" modified="2018-06-20" version="1">MSGPLRVVSQIPRDRNDEKVPRNRDRLSQRYWDRQRFSWREVHRWLYIVCLFRWHRESELDESDERTSASAGLGEEKRRKENGGPYELDYGLISVFIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY43</accession>
    <name>A0A2R6NY43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cysteine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v6881</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000681">
        <property type="protein sequence ID" value="PSR79835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY43"/>
    <dbReference type="STRING" id="98765.A0A2R6NY43"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09326">
        <property type="entry name" value="LIM_CRP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000054">
        <property type="entry name" value="Cysteine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="259"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR79835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="34235" checksum="4208E91BD7DA1EE7" modified="2018-06-20" version="1">MHPFGGTPICPRCSKAVYAAEQIMGPGRKNITKNKTCHVKNFGTRDLRHANLPDRNDVLGSPPGSPMRSGTNLPTHSPRNNAPPLPPRNDTSGGPFSHTRRASPTSPIFRPTRTFSPVRTVSAERNDYVATEQPTDFGATSKHDEDWEPPVISSTPSHTGRSAGGLPRTVPLAPAMTGPPRTTSPTKDSTLPVRVVPTSTGDGATAQGNTIVNGRMSVSLTPKTTGTRYGAALSGGRVASPMAPMAPMATGRQWGGGTPSCGRCGKTVYFAEQVKAIGKTWHRNCLRCTECNHLLDSSRLTENEGNPYCSHCYGKCSAQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYU5</accession>
    <name>A0A2R6NYU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYU5"/>
    <dbReference type="STRING" id="98765.A0A2R6NYU5"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="298"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR80738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="369" mass="40433" checksum="56B8201BCFD67594" modified="2018-06-20" version="1">MSEQFQFLNFATPHPNFDAFATNGYDHTLDYGKPQSFDYDAFPSDAVHLFPTQHLEQFDCEIDSSLAAFDAEVHHLPLDTFDTFTLLRTETPTRSVPSSFTVSSESVSAYDSGYGDSVSVHSESLYNFSDSAALSNEIDMDMKRLGLSPIDDNAFNLSSPGSSHSSPPIGVANFSPTPFSSRGSFSDYDSTAAVRIHVPSSSASDYYPHPVAINKYQPVTQATVSPANVSSQLPAVAPIQPTIIASQRSVKSESGLTSPNGRDPKRKYQCPSCPRAFARAYNLKTHIQTHDPNRSKPYACYHKSCGRSFSRKHDLTRHLISIHRCEAEEAVKGNQVVGVSVGNRQWCDSCGTSWLSNGKTKGCDCDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZE1</accession>
    <name>A0A2R6NZE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000624">
        <property type="protein sequence ID" value="PSR81229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZE1"/>
    <dbReference type="STRING" id="98765.A0A2R6NZE1"/>
    <dbReference type="OrthoDB" id="2792256at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="14956" checksum="820FF3AC7B47393D" modified="2018-06-20" version="1">MVNDSTAILIDTHELQDNYYDLESKNLLPSNWEWSEQAHQAGYNKQMPNLDRIQANGDPLYASFVDYFGDDVSRNQSKSWNKHRNAHVTHWNLPRKLLQQEFHTHFISTSPNASIPKQFHEFKKTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZG5</accession>
    <name>A0A2R6NZG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000623">
        <property type="protein sequence ID" value="PSR81280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZG5"/>
    <dbReference type="STRING" id="98765.A0A2R6NZG5"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3533" evidence="1">
        <location>
            <begin position="73"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="255" mass="27208" checksum="97F5A3DD57EDB652" modified="2018-06-20" version="1">MPDALAENSSLPVLPSTFRSSADNLAEPPPHRFTALTVDEFTPAANVGAGSLIPDIVDDGAKKSKLETVQDDCLYWGALSTAPTLTTSLTAWYINRDAARIGNTLWDSFGNTSAPGQQLGWINVDPDMAGSNEQVMNAIIQGQAWIAVVVEANATINLSHARANGDSNYDPTSAITVYYAQARQETAVGNYVLPITTQLLTSSVTAYTTGSAQRYFAQITPGTTVNQTAVQLLSQAPQTINPAIAWAMVNLRPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZI7</accession>
    <name>A0A2R6NZI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZI7"/>
    <dbReference type="STRING" id="98765.A0A2R6NZI7"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="227" mass="24698" checksum="171CBD3F3D37D4F6" modified="2018-06-20" version="1">MPPSLASSTTLKRIHREIADLKKEDLGNITLVPSSDSLFVWKARLPGPEGSVYEGGFFDVDISLAHDYPYVRTSGANLPSIANEYVRNRAQHDRTARQWTQLYAQPPPPPAPSIVTPLTVPNSRAKGKARHTSLNPSIHSSRANSAAPSTPGPSNASTPITIEIEDSDEERNKRPVASRRPTAVKRKRGSGAVDVDLVAEEEAEARARRRRAGDGPSGLREVIVIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZQ9</accession>
    <name>A0A2R6NZQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZQ9"/>
    <dbReference type="STRING" id="98765.A0A2R6NZQ9"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR81572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="494" mass="55063" checksum="89FB484E96522122" modified="2018-06-20" version="1">MKIKKSRVSKSPVLADDSNGELYNVDVMSTSEKAISSSSHTVSDDGAWEDEPEINLARPDEKSPSPPSRSVRKRKVGSRTIFVAQPNSSRKVPSAKAKNIAADVPPLFDIDREQLRDAFRSGGFYALEYAFDVVKTAIQFLRKPLSFFLFIWLLSLIFSQIHGFLRTIVSPVCWIPGVSRTPLCYTPAPPPRVPKWADYPKLVEMEGSTFEQLLDESVGGSGLSLEIKRAEMATSDLVTLVKVSSLRSKDRMAQYLEEFVADAKTTGRGLQKLSSRIGGAVDREISILAVNDHALHTIEAHQDKSKSALAAFWPFSSTVATREVIIQTFTDAMSVLQTQMQRVVLEAEVSLTNLNNLEEKLSTLHEFVLRENEFISTAKSEMLAELWTVLGGNKRKLHGMDRHLQLLRGIGDYRKRAKAHVHAALQALQGMSEDMEDLRQRVAAPELVGERIPVEVHMKSIKAGLDRLAAERTKAKEKEEAAVRRILGIDEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P050</accession>
    <name>A0A2R6P050_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR81994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P050"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="7181" checksum="044D0E26C67C1CCB" modified="2018-06-20" version="1">MVMYEHNGLPFHSYLSTADMMIVEPAKLDEEEDVKTQMWSLRSRRRALEQWSKIVAQLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0D6</accession>
    <name>A0A2R6P0D6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000594">
        <property type="protein sequence ID" value="PSR82259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0D6"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="15475" checksum="3F4A728F98DBEFB3" modified="2018-06-20" version="1">MSSPPPSPPTLPTVDIQMSSSPPPILLALNIQMPSPPPPILPAVATNCCTSKEKPIPKFILDMTKRNLKRLHHPGSYLNDNMISCGLSLLQAHNGYLHIARWTSKVDIFSKKYLLIPIHDNMKYVHVLNAAWLLSDYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0T3</accession>
    <name>A0A2R6P0T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000579">
        <property type="protein sequence ID" value="PSR82655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0T3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="35822" checksum="515956A6DAF6D125" modified="2018-06-20" version="1" fragment="single">MIEPVSVILASTKAASNGYKLLQSIKPERNIAVGDANLWISNELIFKHIDILPNKIRRRLNRAKERAENVRQEYMDIKNKSNPWSFVIKIHLSRKFKRKCAYVREEVESSTGLAVRDAIEKYDQENADTEATNKGTSALNSHEGQSAQSSSTPLRGYHVRLKLSDPQDRPTQIDVSCGGIDLHVCNGQCSCTSGYQATDPMIAAQGVSQTFNNRTGKAPDTSVLSSSDVESILSKLHSSPLLSRDEGYIVKERSSIITQSTLAEDDTRTETIPMDGEDTEAGTDWDGDSDYQSAYSIELYSVHSEGGPPAERLEHLVMHTGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P131</accession>
    <name>A0A2R6P131_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P131"/>
    <dbReference type="STRING" id="98765.A0A2R6P131"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015309995" evidence="2">
        <location>
            <begin position="23"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="425" mass="47577" checksum="D6B1537F49173AFC" modified="2018-06-20" version="1">MDTRPQTSVVSLWLIFVATILSTPRKAMEMEGLENDPNFWNEFDGNLSEDDVPVVDLTSWFFRDQVSDKAIGWVGIEGESCRDGLPKPPAWTKKRVETSYPSNELQAKDSSKAKSKQKPKPKVQEKAVVDKRLQHLEALHEGTNVKASIQLSEGRRIKIDGKQSLSQKKCRPPQFDFDFANLREEEPLSLGDISAVDLSDDDDLPEPYEILNEFSGNKKGNSSSETSYTNPEMDALIREMPSPVLRRSIQMPQKPSSSCHVEDFTLSSSSPPTLKRPVERQNNEQDAKRAKFASQRETTPLFLAGACGSRSSHDEDFELDDTLFDLRPASPLPKISDMPSSSQMVKSLNHQQELATSSSRTINAFHSGIKETSPKAAYIDAWSAQDPAMYDDDYMLPSVAEDLAELEAFLNSDAVIMVDNMDDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P133</accession>
    <name>A0A2R6P133_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P133"/>
    <dbReference type="STRING" id="98765.A0A2R6P133"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="338" mass="36472" checksum="0157216C53076BAF" modified="2018-06-20" version="1">MPVHLAPFTRQDTQDTEHSESGGLSSTEDLYHGQLPSNSKFNKHSREPLLPIAISGARRSTASRPSIAVTGPYGKSETNVSTTGRMRGSFEKLFKRGLSFETGRKPVNPSDVLDSASMDPAVNCIPRSRQTSPITPTANGRMTFDLAATDEEHSPVSPITRYKNSSTPPAASLTSLQDLVFNPIPPYDMNPPLAETPIVDTKTGKQLRNWQLHPSRNRFFGGGHFLTGGDSPWAFIASLTLVLGITGVWFGTTCLWWWFNESPAVAAVVAYMCLLTISSMLATAFRDPGILPRNLDPDPPSASTGSEDSHRVPLPRDLKVRAGGVITALTAATTIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P188</accession>
    <name>A0A2R6P188_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P188"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015362141" evidence="1">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10439" checksum="A6F3DC787DE75B0E" modified="2018-06-20" version="1">MFAFATCAQILAVASLGFSFSEAHPTAASARLSKRFEDVPIYKSQGLGSACGAIQDDLINCQHCSSGSISLNPYLFEQLVGSDSVNVVYGDWAFPVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1J4</accession>
    <name>A0A2R6P1J4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1J4"/>
    <dbReference type="STRING" id="98765.A0A2R6P1J4"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR83465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23237" checksum="800C7B57AF20DC7B" modified="2018-06-20" version="1">MFIGLALGELASAAPTSGGLYFWTYKYASPDWRNLLSWIVGYSNTMGNIAGVASIEWGCAVQLMAAVSIGSNLTFTPTTGQIFGVYAALLVLNGIVSSTATRLIARLQGLYIVLNVLLCLSIIIALPASTPAEFKNTASYTFTGFVNLNGWSSGFAVVLSFLAPLWTIGGFDGPIHISEEASNASTAIPWSIVSAIGIASILGWGELAHFLIVSSYFYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1L2</accession>
    <name>A0A2R6P1L2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v5722</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1L2"/>
    <dbReference type="STRING" id="98765.A0A2R6P1L2"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="318"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="596"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR83450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="830" mass="92287" checksum="288230FF1D938C47" modified="2018-06-20" version="1">MLLDVNRKLFARSDRVKGIDFHPTEPWLLTGLYNGTVNIYNHETGALVKTFEVAEVPVRCVRFIPRKNWFVAGSDDFQLRVFNYNTHEKVAAFEAHPDYIRCLTVHPSASIVLTGSDDMTIKAWDWDKQWRCIQTYEGHTHYIMNIAVNPKDSNTFASACLDRTVKMWSLGAPSANFTMEAHDKGVNYVEFYPGADKPYLVTASDDKTVKIWDYLSKSCVQTLESHTNNVLFAVFHPNLPLIVSGGEDGTVKLWNSGTYRLENTLSYALERAWCIAVRKNANEVAVGYDEGVVVVKLGRDEPTFSMDPSGKLIYTRTNEVLSGNIQTIADADITDGNRIPLAIKEIGTTEIFATSLSHSPNGRFVTVVGDGEYIVYTALAWRNKAFGNGSSFAWAGDSNTYAVLEGRTKVRVYKNFRERPGAPMKGAGSWSLEGLHGGTLLGGRGSGFVVFWDWETGEVVRRIDVDAKDIHWSGSGELVALCAEDSYYVLRFDRDAYNTKLDEGVDASDEGVEEAFEIVAEIPEQVKTAKWIGDCFIYTLASNRLNYFVGSESYTITPFDQPLYLLGYIPAHNRVYLADKDLSVYSYALSLSLVEYQTAVLRGDMDSAAEILPTIPKEQRNRVASFLEGRGLKELALEVTTDLDQKFDLSLQLDDLDAAVEIARQVPELEAEPKWKAIGDRALATWRFDLARESFEKAGDLSALMLLLLSIGDKDGLAKLAVSAEQKGQNNLAFASLLQLGNPAACVELLIKTERTPEAAMFARTYIPDKVPEAVSAWRSDLQGKNKGKIAAAIASPDENVELFEEGWKDSVHRLETAELQHPPLPINGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1N9</accession>
    <name>A0A2R6P1N9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000556">
        <property type="protein sequence ID" value="PSR83598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1N9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="25472" checksum="BF6606D1852900F7" modified="2018-06-20" version="1" fragment="single">MTTAQSTTPLPCDNKTHCYDADDLKDRYLGPDPHTGKETWTACREKICINRYTFPHYTERNQDPWAKTPDPNQIRLIVEEHGLSDELRREVEEELARRIRLSRPSTTPAQPKASSSSSTRATPATQPIASSSTTQAVPASTAPKPQTPRPSQIPITRSASGSGQPTQQPIAQQQQQPPPPNPPSPPPPTTVIPMAAQNPSLSDVSKAFQAVPELRNNGTNFELWRARVKAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2B9</accession>
    <name>A0A2R6P2B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000538">
        <property type="protein sequence ID" value="PSR84298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2B9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7248" checksum="9A234B69733AB301" modified="2018-06-20" version="1">MASRERPVTEGDLVDAHLSSAHPNMDRNNPYLIKNSSTNLRWILNVKTALYHGWVSYLVRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8K4</accession>
    <name>A0A2R6P8K4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000518">
        <property type="protein sequence ID" value="PSR87078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8K4"/>
    <dbReference type="STRING" id="98765.A0A2R6P8K4"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR87078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="357" mass="39712" checksum="ECCEF0613C5E6ECA" modified="2018-06-20" version="1">MPSLPTRKIGNTEVTAIGWGGMGLSAFYSKPLPDEERFKLLDAVYERGCTNWDTADVYGDNEDLIGQWLKRTGKRNEIFLATKFGFVFSSDRIVNGSPEYVRQSIDKSLKRLGVDYVDLYYLHRPDPSVPIEKTVGAMAEAVKEGKVKYLGLSECSAETLRRAHAVHPIAALQVEYSPFTLDIEDEKLGLFKTAKELGITVIAYSPLGRGLITGQYKGPEDFEEGDFRRQIARYSKENFPNILKLADGLKKIGERHNATAGQVALAWLLAQGDNVIPIPGTTKVKVGSLVLTFLRHLFLNVFLSMQYLEENLGAVNVKLSAEELEEVRKVAERADAAQGLRYPESFMAVQFADTPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBW5</accession>
    <name>A0A2R6PBW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v5076</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBW5"/>
    <dbReference type="STRING" id="98765.A0A2R6PBW5"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015341738" description="Store-operated calcium entry-associated regulatory factor" evidence="15">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="100"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR88725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="156" mass="16879" checksum="748BF2E844A64CD8" modified="2018-06-20" version="1">MLIWTAVLLFILYGFLKSCFGGESGTSGPRSPRRPGPGWFPGAYDNGPTDSPPPYSKHSDTSTSASPAQEQGWRPGFWTGAAAAGLGTYLFSNTNRQDRTRTTAYDWERTRQATGYRPSSFSSSYSGRQRTEDRGEGSSSLGSMRRSTGIGGSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC13</accession>
    <name>A0A2R6PC13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC13"/>
    <dbReference type="STRING" id="98765.A0A2R6PC13"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="178" mass="18730" checksum="7FF5708EFB56F3B4" modified="2018-06-20" version="1">MNEPHDIPAQTVFNLNQAAVNGIRASGATSQLILVEGTSYTGAWTWTTSSGNSAVFGAIKDPNNNVAIEMHQYLDSDGSGTSATCVSSTIGAERLQAATQWLQANNLKGFLGEIGAGSNADCISAVQGAFCSMQQSGVWLGALWWAAGPWWGTYYQSIEPPSGPAIAEILPQAMMPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCD4</accession>
    <name>A0A2R6PCD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR88980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCD4"/>
    <dbReference type="STRING" id="98765.A0A2R6PCD4"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR88980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="333" mass="37963" checksum="22017C6041C2B114" modified="2018-06-20" version="1">MPSTIRSYVLPDLHALCAWKSGFNPHHAEARAASQKWVLGFKAFSGKKLEFFSQGGSELLCSYVYWYAGLEQLRTACDFVNLLFTIDEISDEQNGEDAVKTGEIVLNTLLDEAYNDGSMLCRMTKDFRARFFPHTGPATLRRFLKHTEAYVHGFGREAELREAGVVLDVESYNVLRRENSAVRYCFGLFGFLLGLDLPDEIFEHPIMMEMHLAAVDMVTWSNDLYSYNMEQAMGHLTNNVLTVLMKEKNTDLQGAANLVGEHFKNLSDKFEALRLALPSFGEEMDYVVSKYIMAMQSWVSGNLDWSFATLRYFGADHMKVKETLVVQLYPTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG50</accession>
    <name>A0A2R6PG50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG50"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR90599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="167" mass="18280" checksum="8F1CBC0D69BA062F" modified="2018-06-20" version="1">MFAKSLRVFSNGCPTTGSLGSTALRSGYFSRSLHILPVAPGSIRKSQSRFTRPVVSYPSRRWATSTTPHSTASDPAEVEALQCLEQGTQKLEEGDVQAAKALYQRSVHIKRSASSLFNLGVTHYHLKEFDDAITAWKESITLQPSSPDAHTSTYSSDRLTPLLTTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN34</accession>
    <name>A0A2R6PN34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN34"/>
    <dbReference type="STRING" id="98765.A0A2R6PN34"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR93820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="251" mass="28462" checksum="65186BE3C196BAAB" modified="2018-06-20" version="1">MSPTYLEPLNMYIIVFREGILSFHFRPTPHPQNVRRRIKQLKDYISVTSDWISYALIDDITDAFGPLIQSIEYEVDSIDELVLILKEAEQSDMLRRIGTCRKKVMGLLRLMGNKADVVKGLAKRCNENWRVAPTSDIGLYLSDIQDHLITMTQNLNHYEKILSRSHSNYLAQISIEMTDANNQINDVLSKLTALGTVLIPMNLVTGLWGMNVHVPGQDDQTSYVWFGSIIAVLAAFAVIAGWSTYKLMVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN88</accession>
    <name>A0A2R6PN88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN88"/>
    <dbReference type="STRING" id="98765.A0A2R6PN88"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="213"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR94069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="535" mass="60203" checksum="E1352E1C79CB07C8" modified="2018-06-20" version="1">MALSPLHHSAGLLSRRVLLSKCLTHPHACSSPARSFFSWFKKKEIPKPIAKKYEPVLTEDNLFHPFSKSPFPAVRARGEAIKTLAPCPVCASSSRGDEFGESTLERFHRHTDALPKAVKYECPDCGWPTHCTEEHWHEDEEHAKYCGRLREVNEDEHDLRSGRRLREFELPGPQDSEAAISFANWDLFWYTRGFPSMDTERSRRHASKILTYPLSIGSVLHQHSYLQLSNQRLTPEGSRSLAALRTTLHVPLGTPETEEASADKPQMRIFILGARAESSLPPHVWEQLCMLFPAAMFHLYFIGPQVSLPRPPNAGAAKQTETSSSTTTDTKETTEIKPKEEEKPVYLPNVYEPPTPAPIARLKRTRESLQEYGVPSYTVPYTPQLTITGMQANYSEVHAQFAETFDPYTDCFFMFSPGLGFPSPKSTSETTGEPLLQIASPTEWGPVMPALLATKCPIFVTGFSPADVERDVKSLSLAPEVAGEFDWVITPGPNAFGSEKWEVADFDPRVMVKTNWGVWGIRGKRRDVREKTSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNF7</accession>
    <name>A0A2R6PNF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNF7"/>
    <dbReference type="STRING" id="98765.A0A2R6PNF7"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR94136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="19498" checksum="B00F55847A8C8859" modified="2018-06-20" version="1">MASGGVERLLGSTTIEPSMDIDQTAQASSSSLSGPSSLRKGFGRIIRDENGNIVDVQIAEDDDETSPEPTDRLIEDIPDPSKHNGLEGWVTLGSTARTGTDTTLSGTHVVQSLEEISKTRAGPAQRFTSTGEHGVLERLVAKYKDDVDAMARDRKLNVDQRTAGQLSRAITKAGGFAELMKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNI6</accession>
    <name>A0A2R6PNI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNI6"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="106" mass="11806" checksum="B20207E22878CFE0" modified="2018-06-20" version="1">MVVHHSCAQSYESNSSNDSLPDEELQPFLSDDIEGAIKLEDGGRVTNHSRVTPLPKAQLATLCAVRLVDPIMFTQIFPYVNEMMDHLHLTEDRSKTGLYSGMVVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNP0</accession>
    <name>A0A2R6PNP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="1">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">INT6</name>
        <name evidence="3" type="ORF">PHLCEN_2v4413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNP0"/>
    <dbReference type="STRING" id="98765.A0A2R6PNP0"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR94681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="459" mass="51987" checksum="CE980B7A26A85763" modified="2018-06-20" version="1">MAEYDLTQTVIPYCDRHLVFPLLAHLVENELFPAGQVHAAQYELAKGTNMVDYAVSLFDVLYPNEEVPSEFAGKRESAVHTNERLQQEAQAVLNVIENPEVAQALRQDKNQNLQYLKEHYGVTLEQINALYNFGQFQYTYGNYSGAADYLYHFRVLSTDPDLTISAHWGKLACDILTGKWDIALEELNTLREAIDSRSPSHPAFAAGPTSTDPALAQLHSRTWLLHWSLFVYFNHPEGRTLLLETFLTPTYLNTIQTSCPWVLRYLVAAAVLSRKASATSGSSGRVRYSIREIVKVIQMEEYQYQDPVTAFLRELYVEFDFEAAQKELSKAEVVVGNDFFLAEFKDEFLDNARYLISEAYCRIHQRIDISDLSERLNLSRDEGEKWIVNLIRETRMGADAKIDLGKNVIEINRPPQPIYQTVIEKTRGLAFRTQALGAAMARQGVAQAEGPTAAVEASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVL7</accession>
    <name>A0A2R6PVL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v4374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVL7"/>
    <dbReference type="STRING" id="98765.A0A2R6PVL7"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR97093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="393" mass="43519" checksum="270201F9DF3BFC4C" modified="2018-06-20" version="1">MDAKTQDIDKLKVEAYDVEKSSSTVERANDIDVYVDHAEERLVRRIDIRLVPSSMFIYLLCFLDRSNIGNAKLLNSATGDSLVQTVHISDQQYLVALMIFIVAYTIFETPSNYMLKKFRPSRWIAVLMFGWGVMTMVLGAVQNFAGMVVVRFLLGAFEAGLFPGMIYCLTFWYKPEERALRAALILACATLGGAFGGAIAFGVGHMNGVGGLDAWRWLFILEGIPSCACAIVVFFFFPDFPETAKWLSAEERELAVHRIKGVASLGHAKITWQDAKETLTDWRLYLHYLVYISISVPFSSISLFAPTIISGLGYEGLQAQLFTVPPYAIAFVVTVFVAWQSDKREMRSWGSFLSLMIAGVCFLAQANLKNTGASTLAVPLNVSIGQFGQIVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYS8</accession>
    <name>A0A2R6PYS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYS8"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR98909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="541" mass="60440" checksum="743328DBC5C4FB35" modified="2018-06-20" version="1">MRRRSVQRYLKPSTWALEPAPSTFAPSSRWSNKDMDPVPPKLRTWDTYNYIAYWISDATNAAMWELASSMLAIGLSWRQALPAIAVGHIIIAVVMVMNGTIGARLHVAFPVLNRSSFGFWFSYFSVISRVVLSMFWFGIQTYTGSECVYQMLKAIWPGIQRMPNALPPGANITTAGLMCYFLYWLIQFPFMFISPQRIRWLFLLKALIVPPVWLAMLIWAVVKVPTLKGLFGQHADIAGASVSWAWLRALNSALGGYATLAVNIPDFTRYAKNERAQYVQIIIIPVAFTLAAFVGMMVTSAGTVLYGKVLWDPLTLINEWESRAAAFFAAATFMLATLGTNISANSLSAANDMTVLFPQYINIRRGQVVCAVLGGWALCPWEILASAQGFLNFMSGYTVFLGPFAGIMVTDYWFIHRGRVDVPSMYRPHGRYRYTYGFNWRAVLAILLSVPPAMPGLINSINPKIAVRGAAFLFDIAWIFGFTVASGVYYVSSTLFPAKETYLDQAVLPDDEVWDLAKDEPLEGSFVEKDSVHADAKSVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYY8</accession>
    <name>A0A2R6PYY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000424">
        <property type="protein sequence ID" value="PSR99175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYY8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7544" checksum="22BFCF362FF5762A" modified="2018-06-20" version="1">MTRPGAGSNQELDAPLHATLLYPTLGACVIRTLPYPILAGLAVRYLPVGFAPALRPDQPQSIIKFEEAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZJ8</accession>
    <name>A0A2R6PZJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZJ8"/>
    <dbReference type="STRING" id="98765.A0A2R6PZJ8"/>
    <dbReference type="OrthoDB" id="3233661at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR98932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="336" mass="36921" checksum="B03A75CF48B50B54" modified="2018-06-20" version="1">MIILDEVEDVPKLASPPPIHSDLSRLTRAVTTTPSLPDYETSQEQHRSGAWKPKPLSRRWRWAIYGLIAYFVVTIAIGVPLIILKSRKSSKTYKSPSLLYPAPAAYGSNINNSLSGLDLGIGPYNVDAATACDIWSFKDRQQGNLMHAQLEYYVPTENTVFVQSNVSYSATNNPSYINGRLNVDISDDPKDTNVSIKVAMSYSGTDIRQQTSVCLMNLDGADGLNLYVPYNLDYPDQLNFNVTVLFPQQDGPTSVYICNFITFLPYFAQHIGNLSPGVSFGTVVLEGSNSSVTVERFIQSIQAESIAIKSSSSDIVGSMNVTNQVVLDTISARVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5B8</accession>
    <name>A0A2R6Q5B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000400">
        <property type="protein sequence ID" value="PSS02206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5B8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="180" mass="19623" checksum="9D51D782ECEF9F19" modified="2018-06-20" version="1">MEELDRMAHQDDGSNDSTEETPNVPELSKKSAKATKATKPAKSTKLTKPVRLPRTQGTLRRLSTPAEHVSSPSPAPALTMASTSQTAPIKDEDIDTTINQLNLGKYPDALSSKRRHSSLTLTPFTSPSPLPQPLVSKPKTIKNKGNKVSKCPKTGRRTADSDDDYVGPPQTRKKGKKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5F2</accession>
    <name>A0A2R6Q5F2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000398">
        <property type="protein sequence ID" value="PSS02364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5F2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="6862" checksum="7897FCBDDD4D0DAF" modified="2018-06-20" version="1">MALYRDAGESLVEIPVHAACIQGPSDAEASKQPSGTELFPGSNFSGEKQGSDVTNDLKDDKDEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7G5</accession>
    <name>A0A2R6Q7G5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000388">
        <property type="protein sequence ID" value="PSS03326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7G5"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7G5"/>
    <dbReference type="OrthoDB" id="2442602at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="740" mass="83610" checksum="3E934E91BE3145E8" modified="2018-06-20" version="1">MDPSSSLISRPDLVRTDSGGQISLVEGVDKMNTDEKGRLPPRPVRYKDKFNTLREKYEQVMSTHEQYERELALANRKIRGLQNECDLLLDAVDIAVPGQPRLQYYLAKEPVEPHLMSGPQIYQSEPGAIMPHVGGAQVLPAVPSPLPDQAARPHTNGTNGHDKSRILRFLQEASKQRPSRLLVVTMLLPEDTSTMRAQLERRAELQKQEIMRLQRQLAKTTTEMKELTYVAHLSPEVLSEIFRFYRLGHRMDYEAERSYAWLAITQVCRFWREAALSTPHIWTWITLNQANCVQELLLRSKRLPLYVEPATTRSQHDTRSLVLAMRELPRVAHIELSFRKDTFNFRHLQRIRPQDALLLTHLSIDSESSPNVTIPDVSFLMSQFKTVPRLEVLDLTGILLRSTTPFLVPSLRKLVLCYVPERPSATGLLNILDTLKALEELVLSNTISHSGPDLPVVGVPIATLPQLRFFMLTETDPGTESMTFTDHVEMHPDATVVVNWDPSVTISQLRPLIRHVASRTAGKGYTGSVALPSSVRVHIRGDSVANLDIWRTTRPIDFIARARRLVSEPSGSDPAFNVHLIGHDLGLFTLELCFALAPIPITKLCVLANSPSQSSTHLWLHAFVALVNVKELLVSGCIEGFTAALQNHQQILFPKLETLVIDVIGFHSRVEQPGSTLRHKMKCLREALAARKRRGFGIQTLVILERPEFRRGDMEKFAKQTVANNLEWDEASQYIAGENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB90</accession>
    <name>A0A2R6QB90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v3890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB90"/>
    <dbReference type="STRING" id="98765.A0A2R6QB90"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS05401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="374" mass="40617" checksum="509CD0616AE7E6A6" modified="2018-06-20" version="1">MLRNAIASAVRPALQGRTATTLAAGFPKVASSLPTKKYGGVYTVTLIPGDGIGQEITDSVKEIFEFTNAPIEWEQYNVSGMSSEGEVLFKQALESLRRNRVGLKGILFTPISQTGHVSWNVAMRQQLDIYASVVLCKSLPGFPTRHSNVDFAIIRENTEGEYSGLEHQSYPGVVESLKVSTRAKAERICRFAFDFALKNNRKKVTCVHKANIMKLGDGLFLNTFRRVAEEYKLAGIEFNDMIVDNTSMQLVARPSQFDVMVMPNLYGAIVSNIGAALVGGPGIVPGCNIGREFALFEPGCRHVAKDIMGTNRANPAAMILSATMMLRHLGLDNLANNIASATFDVINSGKVRTADMGGSATTSEFTAAIIKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIS1</accession>
    <name>A0A2R6QIS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000335">
        <property type="protein sequence ID" value="PSS08885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIS1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS08885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="14243" checksum="AC0DFFCB279F94DB" modified="2018-06-20" version="1">MAAYVGEASPDRFVAQLDDISDPSIGLRFSPDTDSITPEEHKQLDDEVYVKMDLPEVADLTDCGGVGQAILTYVVETCPLKYRREGRGGQVVVEHYYNLKQSKLFGVIARMYRARHSFTEIRRISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0Y1</accession>
    <name>A0A2R6R0Y1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000286">
        <property type="protein sequence ID" value="PSS18904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0Y1"/>
    <dbReference type="STRING" id="98765.A0A2R6R0Y1"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS18904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="439" mass="49643" checksum="9C28B23DEA7B739F" modified="2018-06-20" version="1">MASYKDLFRYTSGRWLHDEQRQQALHYRRFNVDALKNVAVSSARAGGITGIRKLAEGRCNQVFHLQLTEGRQVIARIPTPLSGPPHLVTASEVATMKFLRNRLGLTQVPRVLSWSSRSEDTPVGAQYIIMDVADGVELHSVWHQLTMKQRLRLVHKWIIFESKVIQAFIGGSGYGSLYYRKDIPVEDARDLSVDGQIDEEFGQMYHPISSLSPTPNALGPGSLPISQLLTVAHLLLHGNPLRVFSYRRTISVSVAKYFIPSDERLVRPTLTLRDSNQGNIFLSREALERDGTIEISAVIDWQHTAVLPLYLTALIPRFIEQAEPVPEQAEEEFLKEKAYLRKAYHALYQETELDVVEVVAQADEDERTWMEMEDAVEGIEGVVGAESDGWVRNEDYERAVRANETLRRARVENLGKEERQGLGGVNPAEIWPFQGEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHX6</accession>
    <name>A0A2R6RHX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHX6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7473" checksum="535B16A5CA602F9B" modified="2018-06-20" version="1">MPRRPRTRRSAVVLDSSEKLESSSEYFTFFLGRRAIFARSITQSMWQRAAGEKEREVNHEIVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI33</accession>
    <name>A0A2R6RI33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI33"/>
    <dbReference type="STRING" id="98765.A0A2R6RI33"/>
    <dbReference type="OrthoDB" id="3155440at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="474" mass="53196" checksum="B54F0730FC60E687" modified="2018-06-20" version="1">MSINHHLVHMHPADIDIHGSSETATLGSEVVIRGSANSTSNTSPSGILRMPNELLVCIFEHGGRITLQDLGLPFAVLVSHVSRHWRALSHNTPAVWSSIPVRPAHLDLASIFLDRSNGYPLSLCLHVEKVWKVQDALALVLSSAQRWLNLYIRAGTGASVYLVITHLKRINVPRLEHFELTVRNAKPGTLGWLPPIFDPSEDDRRHHPSPKLRSVCLQGISFRFRSGLLSGLTSLTLAYLPRDMAAPMYSEFRELLRMSPNLVHLKLADVFPQVAPGVHYSEIEMRCLSTLDIVMHQSEEYVQTFFGIIAAPSLRTLKFESKWSIAWEGFESAIVSVLAVKFGQLRALHLTVSDTIHLGEYGVNVAFYDAFPELRQFSLNVLDDQLAQYFLKPWAVAMSGGEEDDFPEVAYPLVWPKLELLTVRAPYDEQEEDEDSIDDTLELIGSLRLSLGLPFDVFQACVFADFQMMEPLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIC2</accession>
    <name>A0A2R6RIC2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIC2"/>
    <dbReference type="STRING" id="98765.A0A2R6RIC2"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS29773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60745" checksum="A9F908658F2858F0" modified="2018-06-20" version="1">MPRENSFSDSDGRSLAPDLQDELENYPVHVPHSLPLHAHAASAPKVPHHHQAERLSLDAMDISLSAPASIRERGVHVLSPTKPSVGRGSGIPQRPSILTPGDRFRSSVRKVIAMRRGSIAISGGTIGAEPGIDPRRESAFLTFGHVRQKCLIEIADYSSIRSSSGRMTNQEFISLLADERASAKEPWVKVRWINVGGISWDVVSALALKYDMHPLAVEDLLHFRKNARSKADYYPEHLFLRVLCHSLTPDDDDISEEISHGSMTDFPRSASPAPMNADEESASSWSDIKHPDVEEQKECGRGARFSIGNTARRRFSRLHRGLERQSMETPHQSIHMSNMETGSKGVKNTEVIRELKKDDKVNVKISPMSIFLFRDVVDQALEVVEEYQSRILQLEEAVLLKPTMKIVRKLHVLQGDLILHKRTLEPIKTVIYGLRRYDVDRVAALSERVDPSEKIQGYMSHKAKVYLADVHDHMDYILTSLDMFAGINNIFRDERGYEKAHNDNNHLPAAYTSNGLFRTLYRNNSANMRRLTIQTHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RID7</accession>
    <name>A0A2R6RID7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RID7"/>
    <dbReference type="STRING" id="98765.A0A2R6RID7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="988" mass="107020" checksum="E675A31E18189BE6" modified="2018-06-20" version="1">MSSRIPAPDGTVDDLHYSIVKNSDDGKLFHTQHYIAYREAIILSTASGTYDGPQHIIPILITDGDGAAPCTTIYGENLYFKAGATYSFKARMLKITAKSINVFGEGIVTFDLHGDDGQTSTDAIGPAASGTDGTDNNESATGSQGSVGHTGGNGTAGGSFLLLASSVIGTFNVNLKGGSGSAGSKGGTGGQGGNGCYSKEHYTNTMFSHYKLEDLRSKYRGADGGNGGTGGNGGDGAVGGNFEATILNDCQKLFEVCQDDGSPGGSGEGGDGGAGGKAGEFLLGHTSYSGAIYHRKVANQGGAGGKGSAGSSGKAPDSSQKKKIFTDLVPGSHLPTAFPPDFLQMVCDRLRFEYHILSAATDLSKTSTSPDARATKFLDTLNFLLQTCPAASPAPPDVNPGEGTIATLRSNLRQSILDVKYCINLRIDIWGRRLNSIDTLFFPFYGIKEKLEETRHIEDAYLESKKLSGELNQERFNKANEFAGLVQSEKALDSKISEAALACQQLVEEINQTKSILEYKAHDIEGQLRKAESAVQGHVEWSGFGTLLAIGTVAVAPEAAVFEGALTVLEGADLDFNGITTGGGDNVKKSYVLRKITNVRGDVAEIRDKMKDLFKSMGEGGSEGLEMITVDKDKLTELCDEYLEAIDADGPLRVLFEDLQTQSETFNNLVLSYNEKVVQLHKLISDRNQAKLQQQVLQTASSQEDEDYRKMHLLRYFYSSTYTKHKMALIKQIATAAAGVRALTFTNPDYLASWMNFACFGAVTVDCLVEAWHVLRTSLEDYQLVESMNKTQETSFTARIDAAYPFVVGNLKKNRSFIVDLFPKAAVDAHWISSIWKDVRLQGLQVFLEGAKHRHPSDDAQISMRIRSLDSFRVCDTIDRKHIVCCPEVILPFSYLAKDRTVACKPVNPSSAQFQLDDPKNTEPFRRCLISPYTKWIVEVDEEVDVNDIAGVTMVFNIQGRSTQGKINIMQGGQGFSDRVIEQIKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLS5</accession>
    <name>A0A2R6RLS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000230">
        <property type="protein sequence ID" value="PSS30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLS5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="261" mass="28398" checksum="457C93234D77BA09" modified="2018-06-20" version="1">MSPVPYPSTPSTPRRIRGSYGSTVEPPTSSSACRPTPSRSTRKTRSMAKPPRGTKFPSNGKACHGRTRQPSVKNHARQPLIETAAAADLTRRLQVPTPPPSPMKVDGVSTMPKKGMMEQYLAGRDSARSSSLQWTSPAKDTGFRTGVAQFSTSEVALFPKIGDFANPVTPRSQCRSLRFGADVGRTIYSPQKRIEGTVLSDGWDTWSPRGTIARLNNGIQDPEGSEAHSKVGLNAARERLLEMNAALRLAVPFETTVIFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPE9</accession>
    <name>A0A2R6RPE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000216">
        <property type="protein sequence ID" value="PSS31904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPE9"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS31904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="892" mass="101009" checksum="B7DA3860F0BA840C" modified="2018-06-20" version="1">MPRTPYNVDRLPCLHCKRIFRNVSGLTQHRNAHHGRPRGHLLPAQQQHDLERQPSPLDDIEIVPTTQDPDLELVIYHNTHKLLNGRPCDSSGKFLADPEAPPPPRTERPQSDWTPYNSRLEFETAEFLFQRVKMGQGNVDMLLELWAASLVQYNGRPPFASVKDMLSIIDSTPLGDAPWVTRKAQYNGPLPQDPPPWITAHYEICFRNTLVCAHNMISNPDFADEFDVAPYREYDGRLERRYTNLMSGDWAWSQADIISKDPDTHGTMFCPMVLGSDKTTVSVAMGQNDYYPLYMSWGNVWNNVRKAHRNAVTVVAFLAIPKGMYEPKKRYAKDPVFRKFCRQLFHSSLATILQPLKPFMTKPEIVRCANNLFRRAIYGLGPYIADYLEQVLTTNTVQGWCVTCPTPRPCLGDFYEGPDLRVKEHTELLVELHDLKTLWEEYGVVGDLIPFTNDFPRADICQLISGDLLHQIIKGCFKDHLVEWVNDYLKLTHGETKGNEIIDQIDRRIAAVPAFTGIQRFKQGRNFKQWMGDNSKALMKTEDTVTHISACLRRYHALREIFRTTGTRPNGFHSYLRHHAIDHYPQHIANFGAPNGLCSSITESKHIKAVKEPWRRSNKYNALSQMLETNQRTDKLAAAHVDFAARHMLQGSCLLEAIKSFLSVTADDAPDNDVEMDTTGPRDEVTAENAGPGEGEAGTEPTWDYGDVVEGSRVLGDVSLAKQPQRNYPKTLKTLGRSVNVPHLPQLVSQFLYDQTHLAPLPDDSSQWPPCPPLSGSINVFHSAAATFYAPSDLSGIGGMQREHIRATPSWYRGPPRYDCVLAEKDPSKEGFRGLHAAQVRLLMSFSCNDIEYPCALVRWFSPVGDEPDDLTGMWVHQQNVTSAVQLKCNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVB7</accession>
    <name>A0A2R6RVB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000175">
        <property type="protein sequence ID" value="PSS33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVB7"/>
    <dbReference type="STRING" id="98765.A0A2R6RVB7"/>
    <dbReference type="OrthoDB" id="2804327at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="367" mass="40075" checksum="85E33563B0129784" modified="2018-06-20" version="1">MESEPGLAGVTVMLIDKGITEASTTGVRGQEWINKVKNTLTYLKDHHFTWGDIIEYISDPQHGKGQERWEGFFHSPRWVQQILNWWSSSRNSKTGCCTLQKWAVSYVAGAVEKEGHAATKNGLLQSCKMTVDELFAMGFYIKRLYSQLDAVCPTITRVLHAFSTTAKQRQNNKEGPIQRKVWRVGAALLLLLGERSQANSYSKHVIGLYLYATGAQRQVISVLNSLGICSSYPTLAGSRKLAHIGQETPVVQNRQADELLMAGSGVTVVLMGECQDPQAVELSGSDVSDSGESNKVESDTGSHGRALLELESEDIPLLSSIQHTSSTMIMSALTSAAYIPALPHTPSLNILASSLAFLWPAAQPQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVY4</accession>
    <name>A0A2R6RVY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1768</name>
        <name evidence="2" type="ORF">PHLCEN_2v1771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000144">
        <property type="protein sequence ID" value="PSS34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000144">
        <property type="protein sequence ID" value="PSS34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVY4"/>
    <dbReference type="OrthoDB" id="2795280at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50560" checksum="8F74A09DD6F6B126" modified="2018-06-20" version="1">MRAGYKGLVWIRKLQEYNGGTERATAIKGLEGFGELAKWTAQRLTVWIEPGHFGVSPLLAATPSRQMAHKLIGTAQCLADAETEARSYGSEAIEQEQDEEIDTFDSGVTIDQLEEAVATRTEDENSNEPLQGTDINVKRVKLAENIVQRACEEVIVPATLQDYRRHWAQFCQFAEDEGFVISASDIEKFLPNLPKDFPEWIVAWIMSRADSIDIHTGEEKHPSISRISFGAAQKMRATITHKFGREFGLGTAPWTEDNMKPGRYTGNPSLSPIISQYMAKSGEVVTSARAMNEDTMKQLYKFNKLIPLESLAPNTNKRKAEGLSVWGGYRVRMMLHLLYTISMLCLLRYDEALSIRWEDITPGKTASGIPFIRLDLLVRKTHQNGNIAPFFLYLTPDKPWMDAVLAFSRWWTLAGEMGIDRNGYIFRKRCGYDRVSFNAEDAMVGLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW35</accession>
    <name>A0A2R6RW35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000140">
        <property type="protein sequence ID" value="PSS34233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW35"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="8984" checksum="1237BFB83D32944E" modified="2018-06-20" version="1">MDRNFSSRAPHTYTDPPDPAGPLRKATAMDEEKQSFKSDEMNLVSDLVCDAKADETSKLDIFARKVGNWLSQRGLEGHGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZK9</accession>
    <name>A0A2R6RZK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZK9"/>
    <dbReference type="STRING" id="98765.A0A2R6RZK9"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding 8" evidence="4">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="5">
        <location>
            <begin position="74"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS35472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29448" checksum="4D3E806D73C3C63B" modified="2018-06-20" version="1">MAFPTLGPIESHPFTIANIPEGEQKVKEIIWIIRARGGFTKRLKEHILEKNGACKVPVFLDGPYGAPPDITPFDTCIFFAGGSGVTYTMARFRELLNDATAGRACVRRIVWVWAVRHPSHINWLSSELVKALTSAPTGIELSCIVYITSSPPSTPVSESAAQTLAYGKSGIPKSSQDLEKDVEYDEKQSTAASHSNEGYTPIKGVELLSGRPDVRKILEESITTSDGPVSVDVSGPTPLVSSIRSALSSDFASPMAVLRGAPTVQLNVEDFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3R2</accession>
    <name>A0A2R6S3R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000093">
        <property type="protein sequence ID" value="PSS36918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3R2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5557" checksum="F3E3A94960D38170" modified="2018-06-20" version="1">MTWGPTGQVELVATSGSPMENSAEELSVGSNEIVKAERLVRKMGQKAPKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3Z2</accession>
    <name>A0A2R6S3Z2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS37001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3Z2"/>
    <dbReference type="STRING" id="98765.A0A2R6S3Z2"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="507" mass="55176" checksum="715E68719ACBFADA" modified="2018-06-20" version="1">MSTLAVLAASVSESATPSSDTLNTSDTQRTKEQLRKHYIRALHKVIDESDIIILVLDARDPEGCRSRLVEEEVRRRESEGKKLVFVLNKIDLVPKDNAQAWLRYLRHTTPTLPFRSVSNAQRSNLSTSTAPALVRLLKAYRPSSAQSVTVGVVGYPNVGKSSLINSLKRSKACAVAAQPGHTKELQTVQLERGIRIVDSPGVVFDDADDLLDSGGRARVRGSVLLRNVVKVEDVEDPIELVEEILQRSDREALQKIYNLPEFSNTLEFLTMLALITGRLLKGGTPDALASAKVVITDWNHHKIPYFTIPPTIHPSSLPAMTASGEVAPGAEDVGQARIVTELGKAFELGALFQGADEGAFGDQGATGSDEQEVNMDEAEDGMVEDATVSPTAHKRRRSASPTPSVVPSTDANPNNYTKVNEVREITQRLPKRLRRSHDIPAYDAPVQASGLAASNPLSRRMLKQAAKKARRAARPRGQEEGGGMEMDDDGLGDTFLANNELEMGIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S475</accession>
    <name>A0A2R6S475_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S475"/>
    <dbReference type="STRING" id="98765.A0A2R6S475"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="64"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="233" mass="25788" checksum="A78E8678D9FA2E21" modified="2018-06-20" version="1">MSIEPTSTIRVDVLAGHLGHLTESQKTAFATFQENLAKAQLYSPPQGQDEGGIISRPSHDEPTLLVALYEVMCRFVLPLCTYLPHRTAPTPISSVTTIIDLEQVTITSLWNWRRHLQEASTLATANYPETLSTIVVVNSPSFFPTAWSWIKPWFDEGTRNKVYVLGKDPGPTLRTLIDSRDLPKPYGGELDWKYEDEPFLDDAATEAIGSMPKGPAVFIDGKVEQAPSGSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4E8</accession>
    <name>A0A2R6S4E8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4E8"/>
    <dbReference type="STRING" id="98765.A0A2R6S4E8"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="15020" checksum="8ED842C15E7C9DEB" modified="2018-06-20" version="1">MIAKNLQEYPVIATLPAPAPAPTPATYSDSLESDNWMYGAPHPTIKCLIHRRTQFLPHWQEHQATLNALPQFTHSIEVDRHGWSGYFNEVSKLLPFLAACPPTLATHLSMSLRQVYHALAAPTKTGFAVAQYAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4G8</accession>
    <name>A0A2R6S4G8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4G8"/>
    <dbReference type="OrthoDB" id="2804687at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="637" mass="70141" checksum="2A8600BA0671F1AD" modified="2018-06-20" version="1">MASLSQISHPDSSMGPEHSAIVLSQPTPDISASVPTMMVDIPAGTAQESAPSQYSAARTMDTIRQRFTELTGDGATGSSAPTSLGAVPRSHVSEMPRPLPAFMFTPRSETFPSQASSTRRSLLASHMFHRRDSNPADPSTSLGRRVEARAAAARHRTNRGNEDATTRIRDLASNIDRVVSRFNQQREEVFAAPSSSRTTNSSHTTRSSGRSVVSPRGGTLSRDAGRHRQASARPVNWGRPARVSLPSQDPEEPEWILPFAEDIPQVLPASMSTTSLAYTVSVPSTMPLPLPNAPSSNTSAPRRNFGMPDLESDSDETLPPPGFRVRRRVDAWGVERIHHVMIDSSDEEEEPYSFSISNRRPRPPLVGLNSARVRSDMLGRMRAAEGTQDESGTGMPAPSEQLPLPRDLPSLTGYERLQERFEMAFSGINPSISSSYGITSRPRRRSRGWGAFHLTCYSSTWLTFSSLARLDQDGNEIPTDEEEEYERNRAHMRNRAQALSSGNSFETVSSDATTLPPPPPDYMSYTTWMAPATQSRVPISSEDPGYALVRLNGRARSRSYTPTVIQGDFSDRSRSRSRTRRRTEPLEGSGTSGDFHPSPLPWASVDLTPGTSSRTTEKEKRIYTRRRLSTRSPFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4W4</accession>
    <name>A0A2R6S4W4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Syntaxin 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4W4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4W4"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000069">
        <property type="entry name" value="Related to syntaxin 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33924" checksum="DA8D1A284CB86E19" modified="2018-06-20" version="1">MTAINRTAEFREVLTEVQDTIPPAKRRKVSRPSKRTGEHQRQEQDALRRVELAASMTNPLARFLPARLRQDESSAASDFLAAHHASITWYLSRRLTETSQTLKEMQEERMKRQLERTRTLGSGAAREAMFMTDVPSSSSSEASAAAGGSSSWLGGASTLASSLATIGSPSLGSSARSTPKTASFASGDELLDDTEEDEELELSASQIMQFEMENANLLQNVQDTLASVQQAESRLLEISALQAELVAHLTKQTEQTEQLYEDAIATAATVEKGNAQLKEAKRRAKDSRKWILLFLIGASLSLLFLHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5G3</accession>
    <name>A0A2R6S5G3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5G3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7046" checksum="F9BD4F6CD1FCD5D4" modified="2018-06-20" version="1">MLSNLVVNREYDRATYDASGETASHQGKPDEQEQPSPPHGPGITKPLISAHSVFVNHIHDDHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5P2</accession>
    <name>A0A2R6S5P2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5P2"/>
    <dbReference type="STRING" id="98765.A0A2R6S5P2"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="586" mass="64686" checksum="C8890918DFAB9F59" modified="2018-06-20" version="1">MSPLLRRTSKVACFYCNSAQLPRNAQSFQCSECACWNRYDSHGEIISDDPAMHDENLNAPSFAKRASPRKDRLPSVYGQALFCHTCQTNQMLIANLLSNYLPSQDDPEYTRRTELLPAYRQSVETRYPPVCHNCLPAVEEEIKKRDYMARTSALGGFLQKSRGKGKQRQVSISLQEKHRLDRELVVWRFRGAAWVVGWVGSVTAYGAVIAGYGPPHLSQRFATALPLLVLLSIIWTVWDPTYASLKRAQLQGREVRQRGKREYNILQLIVWMSRLTTSLALALPSYRSSLDDLPSTPTRWYAYLSLSLELAVLIRSATILRVERPPPVQLQARFSHRPSNLNDPSSTVSPPFSRTSTPALGTDPDLLATLSLSNKPITATGNPIFGIPSLPVGGRQNGGDVSLNAMDEDQEEEEERERDPNAMDWSPLSPARNRHQNQNHTHHAPAADASSSAFFVRPQRFFAPEEPTGLENLFAKTIKLADDDRMDGGARQGESRRSRSRSPWGGRGRGRGKTVGRWVVMGVVVLVVPALLGAAGYRVWDVRRRARDGAGGGGAVSMGLDVPVVVVLDTDVGTGGGGGGGPEEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S620</accession>
    <name>A0A2R6S620_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S620"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="263" mass="28788" checksum="5EF3DFF7CF16FDF9" modified="2018-06-20" version="1">MPKDDGMPSQVPRAGSGALHRVAEFLHAFPDDHPFQIALRTYALSLSLSLGPAFIPFVVSAKARARGVGSLLYVLKRELGIHGFAFAMTVGVGGGAALKHVWKVWETTSGEQAGDAATGQDQSLALARFRTWIRSLKDTQKTFITNACSAFLAILLLQSRKSRRKATLTASIPMTLPSSDLVGRASPTFDLTLLILVRAADSITRYTLFKLLPNSKSEGQEASEKVQERRQVITRRIDALVFWACSARLANFSNLKSLNHTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6C5</accession>
    <name>A0A2R6S6C5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6C5"/>
    <dbReference type="OrthoDB" id="2804729at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="56192" checksum="99C03B2560E2E781" modified="2018-06-20" version="1">MLVPFDVLIYLMTLGQRTDVSSMMRTCRTLYSAGMPSLLSFDIRFYDYQRFAAFCSFVNVDAPTRSRFLRKIWLNTDHLAQASGTRTLGHILSILQHAAQLHRLSIDTINEERAGPLDPCLIEAFSSLTSIKDLSILSCITKDTAKVLKSLQSASITKVHICFQREHFSLNHDGPWTDEDNIDPILLLQKYRSSLEILKLYWFIFPPSPHHGIYYPRLTELMITDDCIPLSLELLVYSFPNLRILRIVDLDDFELDFDFDSDTVSDGKECRQANILSQVQMRWESLEYVSSEMLCLYSLGLCCKVNHLRLRLPGYNNTANLSYTTDVLSMTQPTRLSIDIQLSSDRTELIQTQLYHVVDYHGLTHLLIQVDFCPEDSEADYNIPGVLDDIIAALPPLRYMTHLSIRLEYGFCNTDIRAFLSTVLEREHQNIATRAMEAAPALRYIVVHSVHAGHSVWQVTRNDGDASLLEKLTGEAAQKISSEPELRSQWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6I2</accession>
    <name>A0A2R6S6I2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000023">
        <property type="protein sequence ID" value="PSS37894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6I2"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25421" checksum="FB8DEA8B6F360635" modified="2018-06-20" version="1">MNSLVRTNFMEDRDWFAKKYPLWHMLKGEVIGCGINVTDRVVFFTKNGMLIGKCMVLFCGVTTVSQFAHRSRKLRLPWYYKYEKVNPCGQNSYNINSQDDISEFWSFPVSLEFAGSKRSCQSKNMRSAQWMPITTRAVPATATFTVGMSYYEVEVLELHNVNGLIAIGYEQNMGTATANWRNWNDQHMIGAIPSSWGYNSNGIVNCCGNPPLDSRYGPKFQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6K6</accession>
    <name>A0A2R6S6K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000018">
        <property type="protein sequence ID" value="PSS37918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6K6"/>
    <dbReference type="OrthoDB" id="3235325at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="484" mass="52481" checksum="7DE607878A2F03BC" modified="2018-06-20" version="1">MQHGFQATRSSQLEGDFGDNPFVCSAMTGSQQPNGELFSRGHTSSSFDTVLPDVPSSLSSPFIGRTGMIFGMSGNISNMAKSTPSTPFGPSHKNGHGGQVLVSDVTAAPPPPVLRREDYPAVTYWTEDDWNARQAKGTTLLRGKSDYSTAAKCNYVQMADGQSPTDAEWKGMHGAARAAFNGLETAPDSWMANSSTTQQTTVYHTLIKNFPHLGYCNGYWKVEKYVINQYPLWRKARKDKSEAENSQERKSTVPVDATNRAQAVATRKRASEGTSESERDTRKRTRATLLRCGMTAPAVALTVINTTEATADAIETIASQAALVPPTTADVDVGADVATIVPPTIPDLDAVERTGSVSAPALEDIASADSDGHEPLPPTPSSEGQTVPAVTVSPTPALQRSPKRKSQVFQPGPKLTAWNICGRAWKEGRPDGTTAEFTKHWKDMPKAEKKGYEDEAKRLAKTNVQHDDDNIHLIYSHIVDYMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Z9</accession>
    <name>A0A2R6S6Z9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Z9"/>
    <dbReference type="STRING" id="98765.A0A2R6S6Z9"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015218433" description="Extracellular metalloproteinase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS38032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="328" mass="35600" checksum="037DC1473EA4EB3C" modified="2018-06-20" version="1">MFTRTFFTSVLLAVACASTTLAVPWPLAAKHTTHRVREVSSDLRIETFHPESTYETFGEGIDHPLYRRADDDLEEAAVSFVQSHLGLSDGSISFKSGFAGEAAKHAFVKQKVNGVPLANAVANVAFNNANKVVAFGSSFVKPTFVPSTTPQISLEDAISKAETLLNGKFNEWPATVEFVAQEDGSLALTHVVQIQNDETGSWLEAFIDAHSGKLVQVTDFVTKASYRVLPITKETLPEGFELLVDPQDTTASPDGWHSDGTTTTTTTASQTATTSESSTNLIFDFTQDPTQAPTATNNLNAARVNAFYIVNTIHDISYKYGFTEASFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDV0</accession>
    <name>A0A2R6NDV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDV0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="10807" checksum="228D39DCB2285CCF" modified="2018-06-20" version="1">MFEALGAYVEHLLPILVVSYTGRLKQTAVEEVVGRMTVGGYKSRRIWNVTKADLSDVGILFVQLSSAHSAYQMFYSRIGGSRDEFSITLEKFGARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE83</accession>
    <name>A0A2R6NE83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE83"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="284" mass="32381" checksum="946BA1ABF9FEE0D0" modified="2018-06-20" version="1">MAPLTKRQLIPKGHCATFDDLRDTILEQTSKKSLQGLILDDFDDTGHLGERTMAEEVLDHNTRLETTLTLQTSFFPGMEPCLSWVLETPSVQFISKLHLFGIRLRHLADVRQLLKLLESSLEELKIGWLSDMDISEKGLNDHFKGLLTNHSKISSLYLCIQDLRPSRARWVSSFLEHSGFLRWTSSFTQVAFELSPVLLDELEENMETFDKIDRLLEPWVIHYASKDPKDTVLIGNICSLIFHLKCGVVTFQDAATLLSKRFWHLGEGAATMSVGFNDLNHKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEI1</accession>
    <name>A0A2R6NEI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001315">
        <property type="protein sequence ID" value="PSR70797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEI1"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="12978" checksum="FDD8330015C5BADA" modified="2018-06-20" version="1">MIGMKQDGAIALVTFDVIVSIVMTSLFIWPLLRAHFHNSDLKHIARRSVIAASIALSTSCVNITVLAVMHGVELGWVCLACWEADVMDSMEELYNGDASGSNPKLQDVNLKESRKTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NET8</accession>
    <name>A0A2R6NET8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001328">
        <property type="protein sequence ID" value="PSR70768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NET8"/>
    <dbReference type="OrthoDB" id="2736021at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="238" mass="27228" checksum="AEE0A815567E99BD" modified="2018-06-20" version="1">MSDSSRRRHPLHNYLHQMVFSLDYFSHRDLSDVFFTLPDCEEPPDTNLCCSRIPPDPVDIQGRIFEAVPIIFEVVGEICTEDHRFSARVDCTGDGDPPSHGIGSCWITSRLDAASRIQWVRMQATLEEISRLARRTTDEEMDVSTLYRVDESTGDMNLQVYFESPCQHHPDHVSRLHFLSIGALSLTAFTSQTSVMPFQTVHDVPFHQALRVLFYLHLRVRRDGDRSLHAELALMTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF09</accession>
    <name>A0A2R6NF09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v13215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001304">
        <property type="protein sequence ID" value="PSR70901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF09"/>
    <dbReference type="STRING" id="98765.A0A2R6NF09"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="189"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR70901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="994" mass="110020" checksum="0AEDF9BBFE6A09CA" modified="2018-06-20" version="1">MEIRPSPESGAAVGAGRPARELEGLRARGSKFAPRVHYVDPPVTSIPAGLNRQRLRIQQFQRRWQNIKEDLPPQLSRRHIGMISIGGVIGTGLFLGSATALYNGGPVGALLGYSIVGSVVYCLCVSIGEMIAFLPNVGGIVGLADLYVDPAVGFSLGWAAWRYTETVLATEIAAAAVLVGAWDTQHHVPFIGFKNWKEQPFASNYLGIDGSLGRFLGFWAVLMQASFSFFGSEVPGIAAGEVIDATRNVPRALQRVWIRITLFYVGGIFCAGLLVSPNNPALQPNNPRAGTAFSSPFVIAFNEAGFTALWYIVNAAILLSAWSAAASDIYISSRFLFFLARCRHAPQVFATLFRYPSEPNDAAEDAPSDEEDVMDMDDEDLPYTIDIRLEFAEDHAGELNAADNCYDTEDASPVDVTIHSVTNSEDTALHDGGSSPVESSDDPEAATSRKKQPWFVLPLYAVLGSASIGLLSFLSASSTVSAESAFNWLSSVASVASLQSWAGMLFTYIRWFQGTAYAERKNKPYAEDDEESRKVLADIQQIKINRHWGQPYVGVHSQWVENRDNPRRTRPNIRTEPKAKRSSLIIPVFVYSDPSETTRTKSRRSVQKGRTSANCDNRFNDATIGPVVAVFRDPDHIPISEGSIALNPQNIEYIGSYNWVDALRPTIIVPGSPRIWRNSLPLPYSLPGKPVLQFFDENGYRMRVKALSPLVAAVDVVSELTGKPPFDWSSVDIVSDRGNLRLLLKWLQRGGTLLPPFRIDLELAGRRSLLLTRRDIKPSTWVANLWSYGHWFHMLSTEPASGCEVGAGSHHRIITYILKNYDGLRIVLRCEIDACLPSVEDSAVPLSCSSTITTWLPSSPIQIMHGGSIVSQSDLVELKSQSRQARWKSLVAQLYLSQTWTVFFGRHRKGMLSEIRAERLDCDIVQTRLRMDEKGYRKLGPLLKAIRDTAFGRGTKGAKFSLICADRRTLELRERRTNRSCLPDEILQRFEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF18</accession>
    <name>A0A2R6NF18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF18"/>
    <dbReference type="STRING" id="98765.A0A2R6NF18"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="248" mass="25547" checksum="8AFEE8537563BA30" modified="2018-06-20" version="1">MGGFTINPQTLLVVTDMSDGLVDGDTSGIMGLAFQSLASTGAVPFWQALTNAGQFASPEMSFWLTRFLDVSNPTDDEPGGVFTLGGTNSTLFTGDIEFLDLAATSSANSATFWLLQMSSLTVNGQNVQISTGDAALSAIDTGTTLIGGPTDGVQALYSAISGSQALSGQMEGFFAYPCSTELSVSISFGGKSWPVNPADMNLQTMSNDLCLGGIFDLGLGSNIGSGGGNPSWVVGDTFLVSLMDHICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF36</accession>
    <name>A0A2R6NF36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF36"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="191" mass="20928" checksum="C0E94B31DF113023" modified="2018-06-20" version="1">MDRLQEVGRQSPNEVAYCSPETSERLLTVDNFLHIANLRESIPEGKFLPARCSKTRARPESDPEEFQPGGTLIEFNATPLQSPPGYSGGSLSSGPCTFAPIAAPTPLRQSFGFPSAELNLPKVPSLSRRDPDWVLDNCVPVSPDMCQAQSRGLLGQGASKDMAPLLYMRWSPYMPRHPADNDALRAFDTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFA8</accession>
    <name>A0A2R6NFA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v13170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001300">
        <property type="protein sequence ID" value="PSR70948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFA8"/>
    <dbReference type="STRING" id="98765.A0A2R6NFA8"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR70948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="588" mass="66154" checksum="8663B935BA132CDE" modified="2018-06-20" version="1">MKDIFAYIKRTPTREYLLRCSYLEIYNEAIHDLLAPLSTSAAQPVQIHGTGPNVVLSPLREEVVTSLKSVREVLERGEGNRRTASTDWNERSSRSHSVFRVVIESRERGIGGDDGTPSGRQTPGYRPPTPGGARLQARGGRSVQTSVLSLIDLAGSEKATSDKERTREGKYINTSLLTLGSVIGTLAENSAKGKSDHVPFRNSKLTRMLQPSLSGDARISVICTINPDKDAIGESTSTLLFAQRIKKVQLRAQKKEVVDTDALLEKYRKEIEDLKQRLEEREREADAPTRSRRLSAREKLEESKAMRDLNARIQQLTKLILTSQTIDEIKDSRPGSPVKVDFDMTPYQLQQELLAARREIESQGTQILSLEEALLARPILPPDAPESEKDKRLADQAKTIRELEIVVKGYEDNLGEPLRKVKEDVEREWAVRLEKEVKLREEKDEWADELVKQLDKEKKLRMKLEGEREALAAFVKKFDSIGLGISLPPTKLNPPMPTPGGAAAVFAERQRNRVSEHEYALPMTTLVEAESPVRVTVPMASEPSLMEERWDVIEDLSFEVAPNEKEKPGKSPLFRAMSLFKQKENLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFD2</accession>
    <name>A0A2R6NFD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001298">
        <property type="protein sequence ID" value="PSR70989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFD2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="11918" checksum="C5D92AC7AA6A411E" modified="2018-06-20" version="1">MTLYPDVLARAQKEINEVVSWKRMPNFDDEGNLPTMIYGTHSQRVPKLRPTSLPLLPMVSLPSQHDNIQFRFVAQEPAKIRVAFEMFGRLWLYVGTDCDPTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFZ1</accession>
    <name>A0A2R6NFZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFZ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="185" mass="19972" checksum="D4E5D6AD7F6267E9" modified="2018-06-20" version="1">MSTTDDIGLRHMAGSRRAQVYQQQHPFIPATLPNAGGSFEPLTDSDFVLPIHSSELGRLPLHVAFDPHSSPLDDTNGDWRSDFDMAPSAFGSSQLCPDLGNNVTDRALNGVYRPMGVQEACSFMTSLGPSLGPQSSSHCNFLNATPMVHAGGNVMASVSTQPHPMQDFIDNDTLAIWSRAPTNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH50</accession>
    <name>A0A2R6NH50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001250">
        <property type="protein sequence ID" value="PSR71690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH50"/>
    <dbReference type="STRING" id="98765.A0A2R6NH50"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12352" checksum="E70836EC15649D33" modified="2018-06-20" version="1">MAAVMGDVEGLEPTLEEAQKQLDWPKWLATIKAKLKSLNSNDICETFFNPPHSPIATRNGWAIESFDFNSAYLNSVLDDDEVVYLEKPPQFAAKDPKQYVLWLRTYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH60</accession>
    <name>A0A2R6NH60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH60"/>
    <dbReference type="STRING" id="98765.A0A2R6NH60"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="225" mass="25819" checksum="FE01D447A052FC0E" modified="2018-06-20" version="1">MGRVLLKVIILGDSGVGKTSLMNQYVNKRFSNQYKATIGADFLTKEVMVDDRLVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNSSKSFETLDSWRDEFLIQASPHDPENFPFVVLGNKIDVEENKRQVTQKRAMTWCQSKGNIPYFETSAKEAINVEQAFQTVAKNALQQEAEEQLYVDYPDPIRIDSESSQNYGYRQWRHLGRMGVEEEEEEDARSVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHF4</accession>
    <name>A0A2R6NHF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHF4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="481" mass="53449" checksum="A0454E211AE30BCE" modified="2018-06-20" version="1">MEVHEGSSSVVPSKRRRAQDPEHKDSVSDLAKEPGHPFDLSVLDSLRAHVSKVKVDLSEWTAQEPADAAGLPVSQQPGAPVDEAGLMVENINSLRAHISRVKSDLSKWLDQEPADPDVNGLPVVQQSGAPVNEARLQVEGVDPLHIHTAQNSPEIAESTFSKHPRALKNLQQAPQQAGSGILAILDTDAAGSHENNSSVVSSKRRRTEASEPVAKEPERHYFDLSMLDKVMAPVSEAEIPMEGVDSLRGHVSKVKYDLSKREPQEDEKGGDEEDHEAFLSMKAVHDPNSMDVDIPASNSLNLDPLASKLLQGRTDSNRAFSPAPTIFDRDPPIPEKDVHGPSTTQPSMEDVQMLLLQRIMHSAELGRNVKKYVQTTIAGRKTPLIYPLSKSQQLEKWQHMHNLLTGRQIDDNELLPLDYFKDDPNYIYIKQEFMEAMSQDIQEDMDEYLQLTKEIADLKAALGLVEEAFTTRSSFLSKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHY5</accession>
    <name>A0A2R6NHY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHY5"/>
    <dbReference type="STRING" id="98765.A0A2R6NHY5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="208" mass="20639" checksum="E5997F8E9EA16C91" modified="2018-06-20" version="1">MHTLHKNAVPTAALNMLSGSGQSPGSGESPFGNDPSQQRPGAHPFGPPLGVGQNRPGPQQQGKPTGMPPPPSPAMSAAKNAPGQNKDGGPESSTNSSPRNNAAIAGQGQSQGPSPQNASGSQGSQNMGGGTAPPTPAPAPASITAPSPSAILNNNGGVGSQPINQGHSNDQMGGDQIFSADFMHSLGVDNPLFPPDGMGGLDFDRDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI29</accession>
    <name>A0A2R6NI29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001229">
        <property type="protein sequence ID" value="PSR72010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI29"/>
    <dbReference type="STRING" id="98765.A0A2R6NI29"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="9873" checksum="0355EAEAD1248F51" modified="2018-06-20" version="1">MLGAGDLIDSAALAEFLFKCQFKFGGVRKAPEGSPDPYHTYMAIATLSISPPPNSDESLQLAHLDVLWNTTEDTARWIREHVPVSARKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIK2</accession>
    <name>A0A2R6NIK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001205">
        <property type="protein sequence ID" value="PSR72217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIK2"/>
    <dbReference type="STRING" id="98765.A0A2R6NIK2"/>
    <dbReference type="OrthoDB" id="3264373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="591" mass="66596" checksum="1CD32382B571C7CC" modified="2018-06-20" version="1">MSATGPTRTPSKLGILDLKTPQGIEAALEQRHREIEAVLEQYHRDVAELRQRLNAFSLINQRLPPELLAEIFVHYIAETSPSGLETYAPDARPPDYKKPYEWVQITHICHFWRDVALLSPRLWNRILVTQHTNVDCVREMLARSQQAPLFVSVDEEHHTNSDSVDFSLQAILAELHRIRSLELSVSSATLFKHSVHIERPAPLLRRFLLIDIDAQDEVVSRAPLPIATVHLERVILSGYELTHIRHTLLPSIKHLTLLLPPQGFSLELLHSALGDMTLIETLTLSLWDGPSTHAVLGVVAFPYLERLQLIGASVVCAAFLRHTTFPATSTTVIEGLDGADFNSFVSAMADKLNGDGVLGKPAPIKSLALTHPDGNSSAWTLQGWTMERPIESLPKDRAPFQFSVTFNESCSVPHLVELFSSLPSSEVTSVYMGGPAMYLMISDWFNSFKHMERLMFLKISSMSVDGLPPALMMQQDGQVISQRATTSRKVNTLCKPMFPRLRLLVLHEVFFRELVGHDEEILFFELLRKALKRRMTRRLPLRQLIITSAINFTASDASKLKSVVKALEWDGVETMIDDEDSYDDESDLSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJB8</accession>
    <name>A0A2R6NJB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001170">
        <property type="protein sequence ID" value="PSR72485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJB8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10576" checksum="73D440D366CC4608" modified="2018-06-20" version="1">MPPPYPINRSPRPSVKTIRPTVPASPPSTVQCLQVSQGIDPMAEKAGYTTPFVFPVSVVTAFSATSQDLPSTPTLTMLVPMATPFLPMKPRLTKRPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJD0</accession>
    <name>A0A2R6NJD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJD0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6936" checksum="0245ACE13CEBEAEA" modified="2018-06-20" version="1">MCQGYRRDGENETADMLGKFASEACEICVAPSQSVRWLDWSYAHRGKRMANVRVLAEGSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK43</accession>
    <name>A0A2R6NK43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK43"/>
    <dbReference type="STRING" id="98765.A0A2R6NK43"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="340" mass="37805" checksum="5F3DCD5EFC353ACE" modified="2018-06-20" version="1">MSGAAEVARRPSISIPNNRDFPAENGHQALREITYRNVKSLVNVVVMITSGSPYAAVGLVSNPCEKVARMFQFLTDVGAHTEWEDGDFQRTALQYIKYRFNQRPHAYGCNTVNSLSIQLYIAGPVFHEDASDAWEDWMEKSDLPHIHRAVLTDKNRETALKDTLAGIAETEINTPCRQGLTALEWAINMFLPDVVRTLLECGADVHKGIPLHGAAYHGNDEVIKLLIDAGADVNLQDHHGRTPLHRASFRGQASAVEELIRLGGENLLWDIQDNYGRTVFDEAERGRTFFAAIGWPTGHARIIQTLSPFQVCRFEAYSGEPGCEDAHDADLEIPGRFPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL76</accession>
    <name>A0A2R6NL76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001116">
        <property type="protein sequence ID" value="PSR73061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL76"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="14286" checksum="AA59968E5C52703A" modified="2018-06-20" version="1">MDNSLYPGGVIERLRLLRQYQEARKRPVATLDSFNGPFPDRYYSSVSQHPARYHGDVIIYESGEVSSLRQQESWSELKCIHMRYGPDGPISREWTLAFDVSFVTYAIDAGQNLLVLVTPGPEEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLL4</accession>
    <name>A0A2R6NLL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLL4"/>
    <dbReference type="STRING" id="98765.A0A2R6NLL4"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="612" mass="66418" checksum="799E10D31648483E" modified="2018-06-20" version="1">MANVATMGPPPSPKEPRRSGRRSVPSHSASKSPAGSPTSETAPKSKDATQRPPLPSTSSSNRNRRTKNEEIDAILEEPQRTITNGASNGRTKRKEPTNSHGDPQDDDEEEAGVTRCICQETGIDESEAGEFMAECEACHAWQHGTCMGYQSPETMPTHYFCERCRPELYPELLKKHAKRARQSSAASHHTAANPPRTSRSHSPTYLLKQPAKRRNTMNSRDAAYDESLQAIIEASAAEAAANAVPQDGSSPAVVKPDLVVNGQTENDPEAEVVVPGRKKRKRTEDDTNSSKRTRSASIVSDLPHGNNAAPEASPIATTKPSLPLPTTTATKPAPPRARRGGGRKAQVQELAEGEEVASTSSGRRQTSGRSKANAAHEHGARRSYANGVNGHGPSSHAATAAASRAYHNSHAYAVSQQPLFTSWNLPDYLAHLEQLLPTETPRPLELRGFGTATNGQDSADRTTERGVKVKWPSKRMSVVDMNKRVRALVEWVGREQANATERTRRREAVEKSLGERDTATTDRSGALDSVEGRTNSLLLEGGTLTQSPAEEHQLPSLSARFIASLSLEGPGPDPGKETMKMMEELMEELISFQERFGPGAKIKERERRTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLV9</accession>
    <name>A0A2R6NLV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLV9"/>
    <dbReference type="STRING" id="98765.A0A2R6NLV9"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="95"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="265" mass="29231" checksum="73DB6CD2D8115267" modified="2018-06-20" version="1">MLVSRISRRVLAEHHIALTKDLQSRRDGDSSRSDHVGIIYTGLNVKDSIDLCAKHLRSRPYYVDDGVDSGANVNADWPEVIIDGHVDTKFAYIKEHLDYVIFELLKNSFRATRIRHPTASNLPPIKATIVAGENLVTIRISDQGGGLFIPQIKSPSDLFSFSHIRNATRLEDSRLGALRTASSRSQGLRATVDEQLNAMARKESTTDEAPDRSAPHPRIGIGLPMSNIYATYFGGSLDLVSMDGYGTDVYISLPRLGTNLEGIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLW4</accession>
    <name>A0A2R6NLW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001084">
        <property type="protein sequence ID" value="PSR73327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLW4"/>
    <dbReference type="STRING" id="98765.A0A2R6NLW4"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF4">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24362" checksum="A6EC91B031070A90" modified="2018-06-20" version="1">MSYFARTFPRLWIFLTWYFFVLGPRMWRELRHTNFRRLEKVSEDGDEDESLVHYLGRTFANIDGQVSIADTLWISCLILRAVVAVWVMFELSARPSYMPAIREELSEILGHTSDGSMHLTYESLRNARHLDSFIREVLRLKGDTLSIARETVEDVAMGDYVIPKDIHGPNAGVFNGFRWVDPGLPATMLSQGYFPFGLGRWACPGRVLAVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLY1</accession>
    <name>A0A2R6NLY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mismatched base pair and cruciform DNA recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLY1"/>
    <dbReference type="STRING" id="98765.A0A2R6NLY1"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9400" checksum="1AB1ED2AC9E4B840" modified="2018-06-20" version="1">MSSTTTNNEPNKTTGQYHSAKGTVVETIGNLTGAQTWQTSGRDEHAQGEAEYNAAQAKGYAEGTIDRLGGKKDAVVGALSGDRQQETAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMK5</accession>
    <name>A0A2R6NMK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHLCEN_2v10631</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="MLYV02001070">
        <property type="protein sequence ID" value="PSR73519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMK5"/>
    <dbReference type="STRING" id="98765.A0A2R6NMK5"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="537"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="831"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="836"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PSR73519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114081" checksum="62C6E771A3332C3A" modified="2018-06-20" version="1">MSRSCLIAFQNIVPISLYISIEIVKTIQAFFIAQDIDMYYKAFDAACTPKTWNISDDLGQIEYIFSDKTGTLTQNIMEFQKLSVNGVAYGEGVTEAQRGAAKRDGKGDLMDPEEQDRMLVALKGQMLDKLSRTFKNRYMQSDKLTLISPKLADDLADRSSEQRSHLIDFFRALAICHSVLSDRPDPNAKPFHLNYKAESPDEAALVAAARDVGFPFVGKTRNGIEIEVMGQSERYIPLQMLEFNSTRKRMSVIVRNPQGQIVLYCKGADSVIYQRLAADHDPELKDNTSKDMEAFANGGLRTLCIAYRYLTEEEYIGWQRVYDAAANSITDRDEEIDKASEQIEHSLTILGATALEDKLQEGVPEAIETLHKAGIKLWILTGDKVQTAIEIGFSCNLLKSDMEVMILSADTAQSAQLQIEAGVNKIASVLGPASWERNTRGFVPGAQAAFAVVIDGDTLRHALSSHLKPLFLNLATQCETVVCCRVSPAQKALVVKLVKEGRNAMTLSIGDGANDVAMIQEANIGCGLLGYEGSQAAMSADYAFGQFRFLTKLLIVHGRWSYQRIADMHSNFFYKNVIWTFAMFWFLIFNSFDATYLYQYTFILLYNLIFTSLPVMALGAFDQDINAKAALAFPQLYIRGIRGLEYTRPKFWLYMLDGLYQSAVVFFIPYIVWTIGPAISWNGRAIDSLSDFGTTVSVAAIWAANTYVGINTHYWTVITFLIVIGSSVVMFAWIVIYSFFESSDFVDEVIVLCGNGVFWFSVIMSVIVALLPRFLVKFISTSYMPQDRDIVREMWVHGDLKERLGIKHRREPLDSAHNDLEQAPMFHRPHFRSESEVSSFQPDSYSGARSPQGSDGFTPPQSAPTSPSVGGPHEADLVTPIARAAMSPSPFRGSYYSASDIPGPSPTPYDQPMTSLTPYPIATHQPSGNTLQVPALSVVRGHSPNPETYEMHIRGTSDDVSTPTAYGMHAPRSGTDASYATAYEDLGQDAAYDGILHADGRDHLSINHSNENWRESTYSTSSGPTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMM7</accession>
    <name>A0A2R6NMM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMM7"/>
    <dbReference type="STRING" id="98765.A0A2R6NMM7"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="4"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="266" mass="29729" checksum="0367E4B8E1441CAF" modified="2018-06-20" version="1">MPSLRLGNTAPDFVAETTQGPISFHEWIGDSWVCLLLSIKQSTIVNQREHLRQSCSLTLVTSPLYALLSWLKSREGTSISLLIFKSVVNRMNRAPDFAKRNVKVIGISANGLDDHVKWAKDIEEWGAKFAPTTVGFPIIADQDRKISTLYDMLDEQDATNRDNKGLPFTIRTVFVIDPKKTIRLSIAYPASTGRNFDEIIRVVDSLQIGDKYRVTTPVNWKKGEDVIVHPSVSNEEAKTLFPEHTVHKNVPDESAMGASISPDLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMV0</accession>
    <name>A0A2R6NMV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001068">
        <property type="protein sequence ID" value="PSR73713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMV0"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9465" checksum="C9279D6157485952" modified="2018-06-20" version="1">MSQKSQDTQLSMISADRTDDEKTIREEHPDHSFSEKKDIEAGKANSTLDSESVNVPSAETEAVFSDDDIPDGGLRAWSVVIGVSVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN30</accession>
    <name>A0A2R6NN30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN30"/>
    <dbReference type="STRING" id="98765.A0A2R6NN30"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000639">
        <property type="entry name" value="Related to serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="300"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51341" checksum="A789F16DD622A41D" modified="2018-06-20" version="1">MLSTNGPFIPITLPLGLANIRGKQPIDFDGDVNLFHFVLLRCVGKGAFGKVRVVQHKQTRELYALKYINKTKCVKMKAVANIVQERRLLEEIDHAFVVNLRYAFQDDENCFFVLDLMLGGDLRFHLERLGSLSEDTVRFYVAEIGSALSWLHDKRIIHRDLKPDNILLDERGHAHITDFNIAVHYSERRLLTGVAGSMAYMAPEILAKRGYTYTVDWWSLGVCAYELIFGRRPFRGKTNSDLTHSISKDHLRFPEDAESKCSRAGLQALRAFLDRDAVRRLGCKPNGEGFAELRQHPWFQCIDWETLETKEQTPPFIPDSKKANFDASHELEELLLEDNPLKARQRKVQDINNLSVEMRQMEEQFASYDFKKMQRRSYYPQNQQIVSTVTATSSTGVVSSRPVTPATISGDADIVHSDNYGHKPSHETIEMDSRAIPMDEIDNEKAYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNH3</accession>
    <name>A0A2R6NNH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001038">
        <property type="protein sequence ID" value="PSR73970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNH3"/>
    <dbReference type="STRING" id="98765.A0A2R6NNH3"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="7622" checksum="5F42240A6486B7FE" modified="2018-06-20" version="1" fragment="single">MSRGGSRRGDDRGEHQVGPDGWAVAGSTQPRAPPKAGDLSNFGKINKTTSMSFGPSSIFAAGKKESKRDSTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNU4</accession>
    <name>A0A2R6NNU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNU4"/>
    <dbReference type="STRING" id="98765.A0A2R6NNU4"/>
    <dbReference type="OrthoDB" id="3365439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="185" mass="20450" checksum="C572EA1B1E4C1DD5" modified="2018-06-20" version="1">METAGTKRKKPPTFQHLPINRAKKLKQSWVESQKIKSKWKAEKRKEGFVEHPTIAAMVANGHEEDIDDEQHSTNSEHENDAEDPLAGKSGDESQGREEEDRSEADGDKDEESSEEEEAATVEGNQPSHPSHRGKLSRGRGRGTGVRDINLLLDHLKEVAVEAHPLLGAENADEGEVEASLICVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPD4</accession>
    <name>A0A2R6NPD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000992">
        <property type="protein sequence ID" value="PSR74354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPD4"/>
    <dbReference type="OrthoDB" id="5598737at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="20836" checksum="456474181D962A10" modified="2018-06-20" version="1" fragment="single">IQWVANLLVLYVRAGSISRHHKVYKTLIKQIAAPDIVLQLVPYEAIELLRSVGKGNKPAAWLQVYCPAFGAVVNSHSDEGTNLPHELQQIATWLATRAKDVYTRLAQHDPAPIRDNILPEDWQQTGTCYGMPATRRRRWYSKLQSQIFEPDLQSLRQKGSSHTYKEVQALGDQFPGVSWLVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPG3</accession>
    <name>A0A2R6NPG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000996">
        <property type="protein sequence ID" value="PSR74334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPG3"/>
    <dbReference type="STRING" id="98765.A0A2R6NPG3"/>
    <dbReference type="OrthoDB" id="3262173at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="464" mass="51180" checksum="A6123A49E7D96B1C" modified="2018-06-20" version="1">MGTDDQSRVEPEDGGNTAVDVSKSYGDDRQTSKGRVPKKVDEILPGPSPKRAPKSLDESGPSMKPSSKVGKVVHSRTSSIASASTAAGSPSTSKTKAQSSTKPLSAAKSNQPQDSSNLGSPEEVSDGASSIAESTKIRRKRKTEADRIQFIKDDPKCQELEPNRALCSQCHEWIPLHAKRRYVMQNWVAHRKFCVPRPLSTNESGVPLSSDGDTSTENIKAEVNILYPAGADVESPLSEEEAAGKAMLENEPKIGEIQPYMVYCTACTTYVGLTIGTRYCPDQWRHHLTMCDELVARQANSRENHSKTPTWSPPPAQSESFSINDLFIRESHTPPPTRKRAIVHDSDDESEYRSVRARTESYVAPKGNSLWDTLTRRLTWSSPPARSRPICSADFYIPSDSDSPPPPTRTGVTMHVSEDELEERLVCARTESHEAPKGHGLWDNLTRPIRNFVQGFKEGLNQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ68</accession>
    <name>A0A2R6NQ68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000973">
        <property type="protein sequence ID" value="PSR74648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ68"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ68"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1259" mass="140521" checksum="46E0DEC12D617885" modified="2018-06-20" version="1">MLSLSGDRDFEVNGNWGCCTVCPGSKWTQTKNLRAHAKLACYIASSKRAAVLASRTHSAPLHFLQATVEGYVSDDEWEDLIEEPYHLPDENTHQVDHDSLNSLSTLVGMFHAEALRVGVSLTGDDLPPNKAFIAFQEALAGTTIVDAALWPHNEEMPSVETDENVEEQDYSQEEADDATPLSAQEISENYFGAGRGLPEEEYFPYPNQAMMKTDILFSSPRLRFSRTQQEAVLAWGKELGARNVPSLYSLAKFQADSKRALGDPMVKVQTASGNVLYMNDPVKLLAKMYAHLPTRKLLHSLSELTPNKLKEVWQADKWLFEVSDDVLTPMIRQGDKDFYVNELTYCVDGRWFIPERYFEHEGKMFALGRAVTSNPAGLIVSDKCSTVACATFVNNWPEIDTANHGGIQFAPQSVCYAACMPNPDRELADGLEWECPPLIVFIDDVSGNSTKQWNVHYSSYMSHGGLPRREIEKERNIQFLATSPHASPMEILQAICDAIKKSGGKTPMKIWDSLRERYILICPWLLFLPGDNPMQSEACSHIGLNANQFCRCCHAGGTQEYKQSDEGFVTLLKPGHPRVVEETREAILSQLVLSTHASAEKPVKDAMTASGVKDSFAISIIHKLIATGKELRRATLARKALSPDAVNSLLTDELKKYQGKPIMNPLLDMPGFDVHKDTPVEPLHTHLLGIVKYFWAQTVWIMEKDKKLTIFQARLNSLSQSGLNIPQIMADYMCRYCGGLIGKHFKTISQVMVFAITNLVSEDLKNTWLAIGRLTVLIWQTDIQDRGQYLVELLQAIKDVQDFAATLSPGILITKIKFHVLRHLIDHVPRFGPAVLLSTERYESFNQIFRLCSIHSNRQAPSRDIATAFANLDRCRHIVTGGYWFDEQCGRWVQASHHVREYLKNHTLDSRLLGIPMAEKTRAGVTYQSRYGFLEFADLPSRHGVWDQAKSIISHIGDTAECGNAVLVRIEGGKNSPLAFAFIQNILTPTSASHHESQPCVVIALARLEDELHPQLHMPVLSQSTQVRLIDGHDIVCVVNIQHNCLHGGCTVSGTQRLMQEREATSCTRPTVVHVETGQYIINMAALHNHDYIRHALPSSLRLFPAFFSDWGALHWAAAASLRDQKLQKKLAKEASSRKQAEDARRASTVVGGEIASLVRLRDSEDLEPDMDLEIEPSYSMGIVGSLPDLHVEQGHNTIADEEADTGNLVCEQSALVLPEGSDMTEEQPVMPVKRKRKRAAADPSAAAGRAKELRNILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQP9</accession>
    <name>A0A2R6NQP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQP9"/>
    <dbReference type="STRING" id="98765.A0A2R6NQP9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08254">
        <property type="entry name" value="hydroxyacyl_CoA_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="7"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="354" mass="37184" checksum="A224B11644A0E6EA" modified="2018-06-20" version="1">MELPADGKMSAYRFRPQATIPIHEEIPIPSPGPDEVLIRVLAGGVCHSDVDLLDPNGFGANATYTCTMGHESAGLVVALGSSVPSTYPELTIGSYIAVYSVNACFKASCVACRIGRDNLCPNATWLGLGGNGAWASHCVLRAILAVPVPGNIHTLPPAVAAIATDAVLTPYHALKTCIRLEPEQTVLVVGAGGLGLNAVSIAKNCLRARYVLATDIRESSLTQALEMGADHAVLMGGLVGFLQESQTVIDVVVDFVGSQQTFDMAVSLVAPGGRIQVVGLHDKILQFAPTELMAKDLTVGSSFCGTKADLVEVLAAIADGKIQPKVETRPLEDCIQVLDDLRNGKLKNRVALIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRL3</accession>
    <name>A0A2R6NRL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRL3"/>
    <dbReference type="STRING" id="98765.A0A2R6NRL3"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="14453" checksum="A628A6C9AA3E9B6D" modified="2018-06-20" version="1">MAIRIIGLIKRRPDITLEEFKERWGTRHAGILVSTRAVREKIVRYSQFHVLTQPSEALAAAGVPIAPYDGMAEMWVDKIEDLLELFQDEEFQKNVLPDEANFLPENRENMLVLVGEDQPKYERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSG5</accession>
    <name>A0A2R6NSG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000898">
        <property type="protein sequence ID" value="PSR75445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSG5"/>
    <dbReference type="STRING" id="98765.A0A2R6NSG5"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR75445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="390" mass="44971" checksum="EB5A5F68851B266C" modified="2018-06-20" version="1">MDSDSESEVRTCHLPSCRKPGSKRRCSGCHEAFYCDAQCQKADWPAHKVNDCLATTAHRLARAVYKDLLPLDQPTLNDYGFTKALTTDDKQKLFGLYVGLIMYNRVKPQTLHEWRLNGTLVRNIKDVYEAIPEQHRGGYYPWFLQNQYVLDSSLKPPSAEDYVNSMILRAWKFIGGSETDTVDQITTKLKTWPRNRARCHWLYATLLSQAHPAPEEDVWIPFGFCVCDEFSEMALGVLYEELIRRCTFEEFYTAFENSKLADLMDANGFKRRRLSFPDLESVLSTSPHMNLSVWDLKQLVYSEERGPGRVPSVFVDYGFGNCKDEGERGDLKRVYKEYFEAGRARAEPLKLHEACIAGKLFEHVSGVVRLKKDVKKYTRLMKNVYPLPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSQ6</accession>
    <name>A0A2R6NSQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoporphyrinogen oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000871">
        <property type="protein sequence ID" value="PSR75961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSQ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NSQ6"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20630" checksum="325B1A40E262A1F7" modified="2018-06-20" version="1">MPLSVLEAILERSPVPPLPNLRANPSSSVTVVNLIFPPTPTGQPIHSEGFGYLIPRDKNGHVEVLGTVFDSCALGAQDEYASAESPRFTKMTMMVRLQPSSLPITQERILQHLTTHLAPPTPLPEPVYFKAHDLRDCIPAPSVGHVKRMKELAEVLRKEWDGKLAVIGAGVGGVSVGDCIEQGRRVGEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSX6</accession>
    <name>A0A2R6NSX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000862">
        <property type="protein sequence ID" value="PSR76092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSX6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8368" checksum="7698F084025364D8" modified="2018-06-20" version="1">MSPKLDVVHHRVIAEGSSKRQRGVMKHRRVVRGFRVRLRGGEREGVVHISQEEGRDDSEAPGGAEAEEEIEEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT45</accession>
    <name>A0A2R6NT45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v8642</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT45"/>
    <dbReference type="STRING" id="98765.A0A2R6NT45"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="820"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="86"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="171"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1158"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="292"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1181"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="953"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="860"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR76144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1198" mass="129976" checksum="1702449B6C124097" modified="2018-06-20" version="1">MLERTSLSRRAQRSRAASPYPSTRPIKRASQESKTSFWIFPSIWNIFKGHTRSYLDEEAIDVDPNPAAQALGERMRDFEAAQAIMPTPPFINGQPNPAVQPPPRRVPSPPPPPPPPLAESAPNRLSTTPPGQDRPSATRNLETVTAFLNEKQGQRLNKIEYAGIVSLLQESVDDEDKPVPFRFSSSPSTPGPEAPMFAFGSSSASAPSLGNNTSDGEKKAPKMLSKNPNGRYKWMGGGSSKVKNRFQSPNFGPSRSQSSIKLSPEKPTTDSKRRRVGETAQASTSQRSTAAPNSSGTTSSPVANGASSSRPSNGKAPAQSSSVPFPNGSQSSSNLPKANGASSTTRLRTNGLKPTAPAVPSPLRQAWGQSDAASTSASKPTRAANVMAELIKEASPPNKPAFFNPYQAASPVPMKPVVKKPLPPRRRAKAGVDSASATTAEKKIAEQHIAPQPPKERKVEPQLSPQKIIEATVPKGAKRFRPPPDLEKQKPEAVVEPPALRRSTRLRSPDASSGSAQPFSLGTTRQPTVVIEEVEDDDQPSPKKQKTANGARSSISPPSRYAVTIEEVDDVDMPLASRPVSSRPMQPSQIIEPEETAPSASTPSLNTGLAAKPPLGPKSSIPKAPSKLRYSFQVDRDEKAMDQDEEKPKEEEKKPMLAGKGLPSSLGVPRSEAPAPKESPAPKTAEEVKEMVKAIPVNKLPTYSFDLPMSSPGAGPSTLKARDVARTSPVSSLPTYDLTAPAVAPPTLAPSAPASIGFNWSAAGIKKPAAPAGDSWTCGTCALLNSADAKDKCSVCESPRVTAPAPPKSTGFNWAAAGMRAPAPPTGTWTCKTCMLTNPVDKDKCMVWREVSTGRKVAIKKIKVGQFKDGLDMSAIREVKYLRELKHQNVIELLDVFSSKTNLNLVLEFLDTDLELVIKDRSLVFLPADIKAWMAMTFRGLEFCHRNWILHRDLKPNNLLIAADGQLKLADFGLARDFADPGYKMTCQVITRWYRPPELLFGCRYYSTAVDIWSVGCIFAELMLRTPYLPGESDMDQLKTTFRALGTPTEDDWPGHTKLPDYVPVGQFPKTPLRDLFTAATPDCLNLLSKCLIYDPRKRISAKDVSSASSLPKRYSSRMTQALYHPYFSAHPYPSHPSKLPKPVKKASLLPLEEVDGNVEFNSTGPSVRANPPNKLKRKHSQEDFDSRSIARRLDFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT46</accession>
    <name>A0A2R6NT46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT46"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="28"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="577" mass="61694" checksum="DC67195FD865C8B6" modified="2018-06-20" version="1">MAKVDDRSLEQATSVEERKGKGLKFWLIILSICVSLFLSAIELTAVSNALPTIIADLHGEEFVWIGSAYALASTAILPASGGLAEIFGRRSTMLSSLTLFAIGSAICGAARNMNMLIAARAVQGMGGGGILSLSSIIISDLVPLEERGVYNGLIGLTWGCATAIGPLLGGALAQNGLWRWLFYLNLPIAAIAALLVVTCLHLRTPTGTVREKLGRIDWIGNILVTSSAVSCVIALTWAGIRYPWSSPQVLVPFILGFLGLGFFLFYEARWAKHPIVPLSLLSNRTSLSGYLQTFFTPIITLSVVYYLPVYIQACKGHSPVKTGVDLLAVSLSLGPAVIVSGVSIAITKFYRPQLWIGWVLLTVAIGVLSTIQADTPIAQIIGLPILIGVGCGILMAATYFPVLAPLPVSENAHALAFFAFCRSFANVWGVTIGGTILQNELSRNLPAEFLSQFPGGAEIAFSVIPVIHTLPEPLKHQVQVAFANGVSKIWLVMIAIGALGLISSLFMKALPLHTEVDDKWGLEGTEDIKGAMSVQKFTIALNPTEKEISTQSQKRESRLSTARFSVVDFTAGGARFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT61</accession>
    <name>A0A2R6NT61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT61"/>
    <dbReference type="STRING" id="98765.A0A2R6NT61"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="156" mass="16659" checksum="D4D9C8E673FAC461" modified="2018-06-20" version="1">MSTGLASVNEAGHAIMKVDNTTNIPSMPLNQKRNSVRITSQDFYDYGSLWIIDLLHIPYGCSVWPAFWAKGSLWPNDGEIDIIEAINNMDHNQMALHTTTGCLHNASIPQLGANTNLDCGTGAGCVVAETQPNSYNSGFAAAGGGVWATQFDVSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT98</accession>
    <name>A0A2R6NT98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000853">
        <property type="protein sequence ID" value="PSR76258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT98"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8434" checksum="6A7A1D0DFBBBAEF6" modified="2018-06-20" version="1">MGFEVKGGLTRTSYTTKLTALRPDLQTLGPRQLDLKSMRPSAGLATLWVKRYEIVDRFASKPHNQAHFELSETNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTH7</accession>
    <name>A0A2R6NTH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000871">
        <property type="protein sequence ID" value="PSR75960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTH7"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="341" mass="37986" checksum="B414A91A472BADC8" modified="2018-06-20" version="1">MSFPVAEAQVVALFMESIAYGVYVVTLGIACRVLFFDNQGMKKRVNWSMVVVVALMAIFSTLDVSLGLRHNLDAFIFYKGPGGPDAEFDNISYWVNVMKTVDTQMMSLIGDGMLIYRCFVIFSHKWLIIAFPLLMWLANVACSVMIIFITATLRQDTTISQQRLLKPFLYSFFIITIALNLLTTSMIVWKIWRVNKDSSPNVPHISTAQRGLPRSRLEKVIRIIIESGMLYTLFVIMTFICELAGSNAIYGVSDVLVVVVGISFNLIIIRVDSSNNVPNSSYIESGVPSYPLRLVRASKAPTSPGGRGVEVMISRDIDRDIAESDKHGSIKAESRDAWGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTY4</accession>
    <name>A0A2R6NTY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTY4"/>
    <dbReference type="OrthoDB" id="2753342at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8704" checksum="B95168FE341D776C" modified="2018-06-20" version="1">MPKAELLGTFLEILSYGLYLILQIECLRVLWVKHRSGKPMHYLVGTSVAIFSLVTILTGSSNLHMGNMVLERSQTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTZ8</accession>
    <name>A0A2R6NTZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTZ8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="150" mass="16001" checksum="0FF8D1339F24E29A" modified="2018-06-20" version="1">MDDSTANGTQAKGLTPYYRELGIPTVSYLSSDIPSPTMVVTPASFRAPSPTLSQECSSPSSTCSSSRPRPSSSRPSSMATLVASTDDTPIPSNNVAIPLTEIAGEDPQWELTPMSSQDILDRISERVDYALVLIPSKSSRLMPSTHIQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU16</accession>
    <name>A0A2R6NU16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v8255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU16"/>
    <dbReference type="STRING" id="98765.A0A2R6NU16"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015362168" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR76658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="529" mass="58423" checksum="A226B6B700C1C86C" modified="2018-06-20" version="1">MSTSLDVLLLATSWIHVLLAPYTKVEESFNLHATHDVLMYGVSSDALKNYDHFVFPGAVPRTFIGSVLLAWLSTPFIQAANALGLLSDKFQLQIAVRLALATYNVVGLSLLRRGVSRRYGGPAGVLFVLLTCTQFHLPFYMGRTWPNMFALLPVNIASFLLWNRAPNALRPTSKSVHTAIALLTFTTVVFRSEVLLLLGPLILQALISGYTSLSNIIKVGISAGLSSIALTVLVDSYFWQRWPLWPELYGIYFNVVQGNSSAWGVSPFSAYFTSHLPKLLLSSSILSVVGAVIDARVRALLWPAIVFVILLSVLPHKEWRFIVYVVPLFNVAAARGATWLVSMRKSNIIGRLCFLFVAGLLVANCVATYFFTVTSMANYPGGEALSRFNELYASRQNVHVHISNLAAQTGASLFLQTHAPPYLPGYSIAPPEHSAYWRYDKTENLTPTALTASGNITHAIAEITDRAAPNSFAATGFPKHQWIMTAVITGLERLRLDFARIKSMEPWKVLSFSRGDQLVILERRGQSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU31</accession>
    <name>A0A2R6NU31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU31"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7545" checksum="2CC83EB2916C9EB8" modified="2018-06-20" version="1">MHWIHEHPGGTLEQFQDYWEKRIAPQERKDVKSSLWTGLRNSFHIQETPANALRHPRTTAPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVK4</accession>
    <name>A0A2R6NVK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v7801</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Preautophagosomal structure membrane</location>
            <topology evidence="3 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVK4"/>
    <dbReference type="STRING" id="98765.A0A2R6NVK4"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="21">
        <location>
            <begin position="333"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="798"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSR77611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="867" mass="97660" checksum="DE1A5ED2C32F8D93" modified="2018-06-20" version="1">MSSPPKPFTRPLSSSRSLHGSQSIFPGASSSRPFLNMLNPMMGRTYQGYMQANQSVLEEEEEEEDNDNFTGGDLEAGHASRSGSLAKGKQRAGWAPDSSEMNVLRPNIKQDDQRHANDDSDDEVPQDFMIETARKPSQPQSTAYKGKERGNLRQQPLYSTSRKQAPPILPSAGHVSVPPRPSELDVEEDSPPTERLTEPKLKQMRGLDNYERALWNWVNVYNLDAFLQEAYYYYEGKGIYSIALSRGLNLLSADIQTISWPEVVRRIGAIREDNPLTALSSKSPSHQDHTATAKLDAHDIANRIMRQENYLIALFNKELLDLRIPLPEALGRFIGHEEGKGRMLTRALEWNLRFCLMEYLFDASGRVRKVFLKSKNRAILIDGLRRRLIFMGILNAIFAPFIVLYLLMYSFFRYFEEYHKNPSNMSGRRYSPFAQWKFREFNELPHNFARRLNESYPLASMYIGQFPNEKVTLIVRFVAFIAGSFAAVLLLASVIDSDLIVHFEVTPHRTVLFYLTVFGSILAVARGMLPEENTVFDPEMLMTEVIQYTHYMPDEWKDQLHSKKVHEQFGELFVMKIVIYGQELLSVLLTPLVLWFTLPQCAPAIIDFFREFTVHVDGLGYVCSFAVFDFQRHGNVKFGAPTAVSDERLMSKEGKMEKSFLNFKAAHPEWMPTDPSGSLYLSRMADLTTVGLGRRRLLRRSHEFAQGTESTMINAERRVDTPEKANEYERALRQSQMARRRSSAMAQSRLGVPSSSSIFQSGLGLGMAQTAVLGDSNGSILPPTHMGEANLQTSTIPEEDLADDGGVGSALGESYVDGRRPKGPSVSQSQQEEDEQLEDGGVLGLLAEIYGTGANLKGRGRGPPRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVS8</accession>
    <name>A0A2R6NVS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000776">
        <property type="protein sequence ID" value="PSR77782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVS8"/>
    <dbReference type="OrthoDB" id="2804383at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="178" mass="20159" checksum="497CD9DC2F55585E" modified="2018-06-20" version="1">MFGISRWLPAVFSYAGTHLLLSIRKLAADRQRRFSLDGVSTQVPSFVKPSPDTPEAIELQEFINWQTQGSSLLSPDTPVARRHDVERGPVAEFDRDEDRLRIPLARSRPENQRAPPPPPPRRNDAQPVSSEQGAASQDSAGGLPPLALGPPFSIQGIFARLARRWDWDWDWLKDWEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW54</accession>
    <name>A0A2R6NW54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v7819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NW54"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="920"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR77629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1455" mass="164696" checksum="EAE503F367B8BEF2" modified="2018-06-20" version="1">MYSLLNHIAATTSKETYESTTTSRSSLDDSADAATLYSLETGLRGLTEEEKRLVGISTISVVTRLALEFQTEEVTRLTISMLLQRLRTAEPTVEAAIAYNLVDLALEAPAGSFTDIIRVFSSINRSANPDDPRFSNNMVLAAQTRLARELQRRPELYQLYLMELLTLFSDKGVAIQNLAISNCQAKMEDMTEQLASLLLPIDALLSHPDFEVPPNAPSSLIGLFRNMWFLCVLFQFTSADDKDQIAMSWQKPALARIAMKTPPIVLEEAHDTIVSDLEYNPVIRREYAETIIARHRELLTKHIPLRSGEIRGLFPGQVIFLLCMHDMERLRSAIGLPASLVSYFANNSLNKNLALVQCMGSVAEKVMRECVVDLNSLAAKQSLPNALSLELRALLVCSTHRIGRARDVASKYLDRLITSFPSLTCDPSLVFAILEILTLLRRACDNEFFDEDNPVYVFTSEQAGLTLQLTDDYAARNQMLSNLQRDANNWFELALGRAPVELHATLQKYLSMTHAVSLADSSDLGASIAIDFARAFGPIDRKLASLSNMAPPKRDRAKVAADQLTSKAYFSGEASGFHLARILDPRREDTQASPQEVDMLKSRMADAILEIMQKKSILTITDLKRLLFRCASTIISLEQCDHDLIHYLVALPFEAFNPAAISAGIDAWSWVISEKAEYETAIMSELTSAWIETIKHEKGMFSIILNYSDPFYHSVQYSPSDKEAVERAARVAYRALLPHTLILQLLVSRLQAARYRKPGLMLLLQRLILASSRARVHMSTHPLAREARFSLLLFGFEALRSSYLDDYCEHQMRDSLYKAAFSWFAVRPQWSYGANRIQIDTDVKVLSEFLSYLQGDAIRGLPAISSFSPMQSVSNTSYYRSLLKTYNTPLRLLVDNEIFRLTVWANPSSDLKRGTDHVGAIEKLMTEPTWVSSIRTVWQLDPAIAVYMTERFHHVPVLNEVTHLVRSNTKDVLDIPEALRFLVGERIDVHIPRDLKYLLLWAPTPPVLAITFFEKRYHNDPLLLQYAHRVLEQHPVDLTFFFVPQVVQALRYDELGYVARFIFETAKISQLFCHQIIWNMKANCYKDDAAEVEDPMKPVLDKMTDMVVSSLSGEAREFYDREFTFFNKVTSISGKLKPFIKKTKPEKKAKIDEEMAKIHVDVGVYLPSNPDGQVVDIDKKSGRPLQSHAKAPFMATFKVRKTRTAISEDAEILAEQENVRNEEYEVWQAAIFKVGDDCRQDVLALQIIAMFKNIFNTVGLTVYLFPYRVTATAPGCGVIDVVPNATSRDEMGRAKVNDLLDFFVAKYGGEDTVEFQKARLNFIQSMAAYSVACYILQIKDRHNGNIMIDGEGHIVHIDQLVSTVQLMLDTSLPSFKGEPTIRRLNERFALGLNERQAAEWMMAIVRNAHENVRSTAYDEFQRLVRRCLLAKLLTCDVPDQNTPEQRRYNINAIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWH3</accession>
    <name>A0A2R6NWH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWH3"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="746"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114155" checksum="21E8C942616FF20E" modified="2018-06-20" version="1">MPRRTIYNSLRFDCSRCARSFSTQGGLKKHRNSAHKQTQYVPPSPPAGDTLSGSGTQDNNLEPPEVAREFEGDGSEAVPRSVPESRQYHPALNGTTFLFHKSSMYTNCSPFIPAVPCDQDGKPVPENTPPAPSNMQNSDWKPFSGRIAFELGEFLYKEEQMSQRKINKLLELWAASLLEHGGTPPFVSQQHMYDTIDAISVGNVPWATFSLKYSGEVPEGTIPSWMAADYEIHFRDPHLLACQQLNNPGFKDGFDPIPRRDFDCNGNRVYNDFMSGNWSWKQADLLAQDENNHGAMVVPLIFGSDKTTVSVATGQNDYYPLYMSSGAITNTYRRAHCDSVVPIAFLATPKSGRKYDKDPVFQKFRWQLFHKSLAFVLQSLKLGMTEKQLVRCPDGHYRYVLYCLGPYIADYPEQALLTGIVSGWCPKCLACKKDLDNGTHGRRTRELTDLMIETYDPSTLHEKYGVHADIIPFTNDFPRADIHELIAPDLLHQIIKGTFKDHLVTWVGEYLTITHGEAAGNAILDDIDRRIAAAPPFPGLRRFPEGRRFKQWTGDDSKALMKVYLSAIAGHVPDEMVQAIAAFLEFCYYVRRPVIDQQTLRKIEDALTCFHTHRKIFETTGVRTTFSLPRQHSLKHYTWAILQYGAPNGLCTSITESRHITAVKEPWRRSNRYEAIRQMLTINQRLHKLGAARADFEERGMLKGNIFSATMKALLQAHASGEIDQEDSENDDSDLAAEVPVRQSAVADSASASASGEQMEQASLPPEDDGTPVNGKRVVGFVDMALTPQRGYPRTLLGLGQHMKCLSLLDHVRRFLYYQTHPDSDCSSTDLELQECPSIPDSQQVLVFHSACATFYSPSDISGLGGMKCEHIRSCPRWRGKEERRDCAFAQKDGSVPGMKGLFVVRIRFLFSFRIGGRQGVVYPCAFVEWFKPVGDERDPVTGMWVVEPDLDSDGIREVSVIHLDSLIRSAHLLAVFGDKFLPTDFHFSYTLDAFRAFYVNHFADHHANELIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWQ2</accession>
    <name>A0A2R6NWQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWQ2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="137" mass="14612" checksum="2F37A22FE9466EC3" modified="2018-06-20" version="1">MSAVAGPSHRRSTVASQSAADTELYRTVARLSAYDLDGIAGALEAIRSPGVPVTDAELAVRLAREEAEAFQIFNSDRALAQQLQTTWHPLAPNRQLDEITGIGATPGVTGTRIRDPVAAPRATDPLQNGRTQQLIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX53</accession>
    <name>A0A2R6NX53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX53"/>
    <dbReference type="STRING" id="98765.A0A2R6NX53"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="317"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="472" mass="52932" checksum="DF2D75E603C04B5E" modified="2018-06-20" version="1">MSYPTPAEAGIIADAEKLMVDTMARYDPSHDAFHVQRVRKNALQLAHSLSAQPGARKPDLLTVELAALLHDVLDKKYVSADEAADPYGFFLPFFEAAGKKHGIDLIKDGRAQLIAKIVTNVSWSTEKKLRQAGLIEDWHRECVELHCVQDADRLDAIGAFARTSPLHTPASDPRHDDTAIQHFYDKLLHIREQLKTERGKQLAEKRHRLDGTPTQRSIDGPSVWVTCVRGKERQAVGELYDLFGQLASELWPDSSLTTGGASIAEDSDDDADSDIEKAIAKEVSSMKRPRKEQRFVVILSCKSPVDPVLLVTKHVGNVLEKGVTHTRYTQRLSPISATCSTNLQEMKTMLIRLLQPFLSADEEKVFSYKIELRTRNHNTLSRPQIVQELATCVPAQHKVNLEDPEVFILVEIFKSTCGMSIVRDYYRLQKFNVMEIAKTEEPGFKPNEGRISQVTKSKESVTKEGLNTIADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXW5</accession>
    <name>A0A2R6NXW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXW5"/>
    <dbReference type="STRING" id="98765.A0A2R6NXW5"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR79610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="362" mass="41121" checksum="D3375E5D951AEE2A" modified="2018-06-20" version="1">MTGTKSALEVKEDMTFLDLIVRQVVHLNTTNHVDVPLILMTSFRTHDDTLRIIKQYANQSLRITTFCQSRYPRIYKQSFMPCPKSPDDDKDKWYPPGHGDLYKAMVNSGLLDQLLAEGKEYLFVSNSDNLGAVVDEKILQYMVDSNTDFLMEVTNKTRADVKGGTLIEYDGRLQLLEIAQVPFDHADDFKSIRKFKIFNTNNLWINLKALKQIMDKEEMELDIIVNPKTTEDGVSVIQLETAAGAAIKHFQNAHGINVPRNRFLPVKSTSDLLLIKSDVFTIEHGQLIVNPNRMFTTAPVIKLGEHFRKIADFQQRFAQIPKITDLDHLTVAGDVYFGRNVTLRGTVIGISASPYEAYLGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYG5</accession>
    <name>A0A2R6NYG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000661">
        <property type="protein sequence ID" value="PSR80235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYG5"/>
    <dbReference type="STRING" id="98765.A0A2R6NYG5"/>
    <dbReference type="OrthoDB" id="3265715at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015315727" evidence="3">
        <location>
            <begin position="18"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR80235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="656" mass="68921" checksum="8BE98846798A32C5" modified="2018-06-20" version="1">MVLWSFLVLYLLSPAPSIRSPLLLPGSSVSYSGSLALAILVNITLDDTSSLITYLPASSWHASTNSCTTCLTPSEQLAYAGTWHDGTHIIPTVDNDDQSGTQTDADDPPKPASSSLKRPASTSSSKAPTATGKGDDDGDGGDDGDEDKGHSSSGKGKRRRVVESIRDLALRRRQDVDDNNPFFTPNLDSDDPGFVDTPVLAEFNFTGSAIYVYALVPLFVATSNSTPTFVNLSYTIDSQPAGNFLHAGSPSVSPSSNTTSYQRGVPVLAKTGLSEGPHTITVNVGPDSVFLLDYIVYSQEDDLRTNVSSTEGGSSSTTGPPTSSVTKNAMPSAALSQSVGTHSSKSHSVATFAGAVGGSVGLLSVLALFLAFSLYRRRVLARRRDRAYREARRDAASISESYHTDASEDGPPMQGPLPFIPRYFPGTVISTAPPPYSPPAPPSNSPTSALLGPPETPVPSMMWSSRRLGIIGDSESYAERPPPTPPPNGSGLGADLDDDYFAPPPSFPMAISTPIPAILAGLSGAPIASQSPGPRSPTPASPVIPLLAPPPSSRPPTLSLADQSPGAGPSSSRSRSVSITSGRASTHSLRVPTQDTEERVLTETDASSIVHSLYDSDRRSLERVESRYVLGSGTIPQGDREMRGQNNRGNDNSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ60</accession>
    <name>A0A2R6NZ60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ60"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ60"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="10106" checksum="6AB8B1466FD6293D" modified="2018-06-20" version="1">MKAYYHDNLPGDPRLPHINASAESVTDLTLKAIGVLHWSIPVDSDGKWETEIDEVAKEREYRNRDVVESSRETLGDQFDKKMAVVYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZB6</accession>
    <name>A0A2R6NZB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000645">
        <property type="protein sequence ID" value="PSR80621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZB6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7508" checksum="E34201BB14639006" modified="2018-06-20" version="1">MSEGMNIDALYRRITIQLLNILDVGRSIVHPFCHLVTVIPALATRSPALKHCVGPMGYGFWPLFRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZZ8</accession>
    <name>A0A2R6NZZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZZ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NZZ8"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="202" mass="22415" checksum="5CDD553C99E08D5D" modified="2018-06-20" version="1">MNSLSHDVALNVYFDGRLVNRSSLRANSSGLLAGSRTQDDMLRPFIFSVIDTTEDDNAPINDINLEMLGVIQVDYFRTTVVNEGVAGNVAQQNFREIGPVSERTKKAGVHHVALDSASVKARKQHMDVVNYIDPGNQPYLTFIFYYRPQEILQAQGIMPPCSISADAPCFSVQDKEFSRAGHGSQRQDGHTMSLRNICWPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P031</accession>
    <name>A0A2R6P031_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v6260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000606">
        <property type="protein sequence ID" value="PSR81829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P031"/>
    <dbReference type="STRING" id="98765.A0A2R6P031"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR81829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41148" checksum="086E4C8EC622B8B6" modified="2018-06-20" version="1" fragment="single">LNPAFSILHMRHMTPIFYQTIHRLREAIQLEISQSPSRNRETGVEIDVLSWMGRVALELIGQGGLGYSFDPLVKTEHNAFGEALKDVFPTVGRCTTYRFLCHHANKFGPPRLRRIFASLFPDRNIQTLKRIIDSIEDRSKEILEAKKGAILVEGDDEVLKMEVGEGKDIMSILLRANMKTEGDDKLPDHELVAQVSTLVLAATDTTSNALARIFELLAQHQDVQDKLRQEILDACDSQDGSFTDIPHDKLVELPYLDAVCRETLRLYPPSSFVMRETRQDIMLPMSEPVQGVDGSYMQEILVPNNTLVFVGIQACNRNKVIWGEDALEWKPERWLNSLPNSIKEAKVPGIYANLMTFLGGGNACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P044</accession>
    <name>A0A2R6P044_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P044"/>
    <dbReference type="STRING" id="98765.A0A2R6P044"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="230" mass="25356" checksum="60FB0DE5B8DA5F2E" modified="2018-06-20" version="1">MPTLNTLANIGAITLQCHRVAKFGKATPYELKQVDLGMKEIPETAKKAGAHKISLGAARAITSVATQMFLKDSIDKPYATFCLQYRPKEMLQAQGIMPLDVVGVTVVACGPKRSRREFSPAPRQQSGLPSPSKRIRTEPVSPTSQARWGIFSPAERYQSPSQKDSRPKVKPEDVEVIEDLEARRAAAMNQIRELEVRLEIARSQGDRVKREPSPIRLGGPSGEVIDLTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P084</accession>
    <name>A0A2R6P084_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR82001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P084"/>
    <dbReference type="STRING" id="98765.A0A2R6P084"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="88"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR82001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="403" mass="44851" checksum="5447337B70F7D6A0" modified="2018-06-20" version="1">MAPVATTEQTLQSNGTPKKAVSNGIAKVFNPFYSPPASDENDGTYKFAHYKPSFPDIVWAPLEEQEVTDRGLSADPEKNALFSAATKVQHLTPAIGTEITGIDLRQLSPQQKDELALLVGERGVVFLRNQDISIRELLDLHRHYGPLHKHATTGVPREPGLEEVHVVYSDASRRPDPSAFSKIELWHSDVSYELQPPSTTSLKLIEGPPYGGDTLWSSGYALFSSFSPLFQKYLESLYAVHSAVAQADGARAAGHTVRREAIETIHPVVRVHPATGWKSVYVNPGFTRRIVGVPKAESDAVLNLLFHQISDNPDFQVRFHWEPNSVAIWDNRVTTHSATFDFYPHTRHALRATPHGEKPTSVEEYERHGKVAKDRQLEIWKQTGISLPESAQLGKSTPRGYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P100</accession>
    <name>A0A2R6P100_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P100"/>
    <dbReference type="STRING" id="98765.A0A2R6P100"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR83044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="314" mass="34442" checksum="1409636477E26DEE" modified="2018-06-20" version="1">MARRLYLGRLPPDARTEDVSKFFEGYGRIVDCRVMTGFGFVEFESSRDAEDAVHNFNGKSFMGANIVVEFAKESRPRRDVYEADRAPRARRPPGFRLVVSGISRDTSWQDLKDFGREAGSVSYADIDRDRVGEGVLEYLSRDDAERAVKELDGKDLRGNAVRVTMDTAVLAPTIIVVMTAVTTVVVTIVIPVTIVMLAMTATLATIVTVEMIATPQEKTVVAGKNAQRTPGNALDRRPAVRTMMIVALGRLLPRGKWMIGGLQGTMIDGDHMMSGEALTLILIAVGMNVAVTRRRTASRRGHQEPMEITVGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Y5</accession>
    <name>A0A2R6P1Y5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS41 SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Y5"/>
    <dbReference type="STRING" id="98765.A0A2R6P1Y5"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7261" checksum="739DA208C5A72CCE" modified="2018-06-20" version="1">MGLAAKIDSPTAFLTAIGRSAETKVTPETWEELWKLDRQTLKKAGLPVRDRRRVDVILYHVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Y8</accession>
    <name>A0A2R6P1Y8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Y8"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="311" mass="35193" checksum="FBAD95C671620974" modified="2018-06-20" version="1">MPDGWEAKLVMVDDRSPCDIYKAGDANIMQWFEKAYSEAGAIKFCQRIIHEGYVLPILTSIALAVLAEMYTTTSGAQSKQRRVRLKYRSSPIADFGIAKGSAVVTGEDKLAYYRMSDGSITHGQDPDDHYWLYFTTIRGEDLILDLSMFTFNMCSMVHLKGYVDIPEIQHIIAVVPAYFQERVVRINTPPLHKERMRISVLRNNALHDAIVHTHHRTIYPEDEAPIISFMEKLAGRKVTAAEKKLAFALTADHCEALGETLKERRWTKYPAAPLLAIDSDPGEMDPEAIARFNMKEPKVKKKKSKTNTVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P251</accession>
    <name>A0A2R6P251_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PHLCEN_2v5537</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="MLYV02000544">
        <property type="protein sequence ID" value="PSR84035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P251"/>
    <dbReference type="STRING" id="98765.A0A2R6P251"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="53"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="503"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="58"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="447"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PSR84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="639" mass="70083" checksum="9E9A7362D1BF3051" modified="2018-06-20" version="1">MLRKSLPRVLKTAQRSFTSSAPACRVAATNPVKAEEVSSWASGKYPLIEHEYDAIVVGAGGAGLRAAFGLAEAGFNTACITKLFPTRSHTVAAQGGINAALGNMTEDDWRWHMYDTVKGSDWLGDQDAIHYMCREAPSTVIELEHFGVPFSRTPEGKIYQRAFGGQSLKYGKGGQAYRCAAAADRTGHALLHTLYGQSLRHNTNFFIEYFALDLIMQDGECVGVIALNMEDGTLHRFRAHKTVLATGGYGRTYFSCTSAHTCSGDGNAMVVRAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGYLLNSEGERFMERYAPTAKDLASRDVVSRSMTVEIREGRGVGPEKDHLYLQLSHLPPEILHERLPGISETAAIFSGVDVTKEPIPVLPTVHYNMGGIPTKYTGEVITVDEQGKDKVVPGLYAAGEAACVSVHGANRLGANSLLDIVVFGRACAHHIKETLTPGKPHKVIPDEAGLDSVEFLDKIRNADGPLSTAKIRLDMQKAMQADAAVFRTQESLDEGVQKLRQIFKSYDQVGIKDRSMIWNSDLVETLELRNLLQCAVQTITAAAARKESRGAHAREDYPERDDENWMKHTLTWQHDPSNPEVDIKYRGVIATTLDENECKPVPPFKRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8W8</accession>
    <name>A0A2R6P8W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8W8"/>
    <dbReference type="STRING" id="98765.A0A2R6P8W8"/>
    <dbReference type="OrthoDB" id="2757320at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="576" mass="63971" checksum="7DB3CB791190D24F" modified="2018-06-20" version="1">MSDSIHDKKEMSRAWNIEELVCYIIELAALHPRVYEATTISEAFEVDLQTLSALARTSRAIGELALHRLWQRQWGLGNLVRCMRSDGDTPWTEVTTEGFSGAHLEFVRTPLSGEWARFHYYARRIKRLDFITSDISNGYTALSPDAFHMLSRHGTLFPNVECLHWSIHAVGHEAMAFFIMFLGPRLTDLSISTHACNSHRNNAPDESVMQDLENNIKLYPQLQNLGLYMFGSALCAEKLLNILARLNDLRAFNCYMENTPLPRAILPILASFPRLGSLDLAIESPEADRAPGVPLLQPDDAVSAGSPVNFETLKRLNLRAFTVPPCVDALKAIEAPNINRVTICATIASDLQSMSQAISDRCQRSGARLYEIIWHDAYIESDGLDIGEDPHDIVTIHTLRPLFKFEYLVTLEITLPCTFDLTDEDLGEVAHAWPCLRKLSLGPARWNRRSKITLDGLAVLIDLCPDLTVLDIAIDATNPTNCAEPYRIEHPNPEIYSIGVADSVVSDPVEVAARLGYMLPNLTVIDVAEMGGAEMGEVDNTLSALWSAVESHLPVNAATDAEDSDADDSQTMDVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBX7</accession>
    <name>A0A2R6PBX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v5134</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000508">
        <property type="protein sequence ID" value="PSR88583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBX7"/>
    <dbReference type="STRING" id="98765.A0A2R6PBX7"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR88583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="526" mass="56544" checksum="1603C71AAA7F296B" modified="2018-06-20" version="1">MDPDVPVKTSVPVVILGEKSPGVKRIEVISHSLNKWTKVMLFVGIFLIAYAYGLDGSVRYVYQTEATSSYATHSLLATVNVLRAVIAAAAQPTLAKLMDVFGRFEVLLASVVFYIIGTIIEACSNNVESFSGGAILYQIGYTAVMLLAEVIVGDTTTLRNRVLFSFIPALPFLINAWISGNITAAVLGATTWRWGIGMWAIIYFVCALPLLGTLWFTARRAQNSGALQSYKTPFQQYGFGKLAIALFWQLDVVGIVLVIATFALILVPFTIAGSAKEQWKAGHIIAMLVVAFGESVESATRILNVYSFTSVIAGTAMGFAVRHFRYLKPFIIFGVSLFMVAFGLLIRYRGGGGSGSHSAIIGAQVVLGIGGGFFSYPTQASIQAQTKHEHLAIITSLYLASYSIGSALGATLSGAIWTNVLPGQLISNLGNATLAGEVYASPLTVALEYPMGTPERIAIVNAYKHTQKLLCITGICLCVPLLAFACLLRNPKLTDSQSLPQAEGETSSEYTHDDGDSVKDQKFPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PFZ1</accession>
    <name>A0A2R6PFZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000496">
        <property type="protein sequence ID" value="PSR90429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PFZ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="143" mass="16205" checksum="213C03492AC42D6A" modified="2018-06-20" version="1">MGNFNVFLAITSDPLANRSLSPLFFLPHFLSKSIQLENALERYALALDNVANLCKMANAVATIERKVTSDLYLWQVCRQLVECRPIVEVFSKKKRAAKVYCKKNEAAKTCKEEACVKDEPLTKKAISYNQKKQELTTKLAKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGV3</accession>
    <name>A0A2R6PGV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Golgi-body localization protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PGV3"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1267"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="1388"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1786"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2112"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2558"/>
            <end position="2612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2785"/>
            <end position="2819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2836"/>
            <end position="2905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2861"/>
            <end position="2875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2882"/>
            <end position="2892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2893"/>
            <end position="2905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR90705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2905" mass="324003" checksum="162F44AE641A6ADD" modified="2018-06-20" version="1">MPWNVFSSIALFLNTLFLWKPQNSLSASIVIWLVRITTFSLLFRSFVGPSVLRLLNNRLRVQSVSLRSIRGIYFRAGKGVLHVDRVGLSYHRPSGQNASRFSIMVEGLRLEIAQSEPKGSRKRSSESSKRSKFPQLSDLAPSPLAMHTWAGACFIYSALYSSVEPFVRPVVRTFIVAVLRIMIRALPALTQVLDLEIDSAVLSSKTIVGAEVIIHKAKLHTSVVFTQLDNSSNSGALPHPTQPRHKRFVSVVDMNTRLRNSFRRTWERAWGSTQVAASVSLSVQEVLGVALQPLLKEMHTSFQGEFIIRNGSNKHTFVVIPNIAFTASVRLDPSQKVERHGLETSLSSDAASLDIDVVQYILKQLKKHDEHNEQAESVPPSSPPLSPSLSRFTPGSPAMGSPQSILERGSHSPGARRTSRFGWVSPMSPTSPIMEALSMRFRWKPKHHPIRRIRGSKYMTHLSTLKAVHVNLPSLTLIHRLVMDEDKHPQTFRANLQQIGLNITLSHPDRVPLHREQLGRTSAPSDPLTADVYTLGFSAHHVTLDRIGAGAVRDHLRILGLGPLNIAILVSQWPSPWLQGPTFLSGDPNVQFLTARVSLGKIEMTERLEVVEQLLKRNQRSQRPEAAEGRPSLPAVLSPVPRISIGLHVEEVCIRLISSGLHRGTVPFALEARTDGFTASAETHFQMLPDSNFGRLLTDHDRPRLQMKIAVHAALQRTFVNVNRATEWSTDDPRASLGGSLYPGEPVMSLDTLQLTGDGHAFGEMADEPGGGVTIDVASTFLNLHCATDALSVELWQPDAVAALKAIAVSLKTDPPEHPVPPSPPSYLLDKLPVGISASFAVARLMVFITGPDLAPGDDLNISRGVASHMGISLHYCSLKDKHCDGLSDIRSRTQQRLLLSLPTELVATAAGSTSAAALTQSHQALVQVAVWDLALRDALSTRFVADDPYGVGDMSEDYRSQEYLRVEHISIGIAISGRRVNHVPFLRSMDDCAVSVAVSHVRGYFHLAHAYNLLLAAQALKNLAPAKNIPPPARGPPSTLAYNVHFELDRVQLSWEFPLKMKLFTRIFALSAQRPASGKLKLQWDQVLLAVPLDVERDGTPRVEWMELARISNWSVDIRPDVHPVAISAQGDSARLHIPYDYVLADLILDINLTVKCMKHLTRMIPSGQFENPPAPEAEEAKSMPDLSIRIGCLCVEAADDQFETQLGLIWRTGYESARLRLEREEAFEAKAAAVRAANQQDPSTPNRELQSEFQFTPEHTVSVEDALNRLYSLHAGSWASGFRQARAQQVLQQQTEMQRSMGKVDPPDALDTDLITIVTAPPAPPLIRLNFDALSLHITGPSFPSSNLPDFLFNEGGGLPRDTQYSLLIPMHLTFSVASLRATCREYPLPLLNIPASSQKEIPGLEFDSDVVIAEEIGTAHTVEWIDCAIVKAHTGVHGAPPLCVAVPKTLNPVKSYANPIIRVRTDDVTDFAWGVSYGPITQDLMRVVDTLSHAPRDDSPPIGFWDKLRLVFHWRLKVFFENDVHFHMKGSHDPHGLHGMGAGFALCWQGSPQLFINQKNAQNELIQVSSDSTLVVIPNIEESYGESSTMGPKTESHGTSASNKKCLPRKVCAKFDSGSRFGVGVVLERTCGPDCPNCTGGAFDRQCRFFDFRPHYEVTLETKPQKPVENTPQDSYNGFRSDFIHLSISLTSSLNKDSDKYSSIHLSPAVFAHFWSWWTLFDGNALPIRQGRRYKHKRPLSPKFGQHLATIKYRIEVPHLFLSHIYMDESRDAWTDGVTPFVGVKAMIGRFQADMHQRTQQSTITTPDGAEKILIHKPFYAVEVVMKDLELRALLAIFSEPLKQRVPLEPNFLESSYRKRENIPVTEANSPWVDADDFLDVEWVSSETPLLHLLPVVSCPRFTYFRRASANTSENRVERTKFGDENSHECLLGKEASVLQAQIDIVRNRITELRDRSANGADPCASTRPERQFTTDTNYMISLLETYIQKLEEESRTVPSNEPQSYYMPSDSVSSKDWAEFDNVYQVHCPKLYLDNIVRDIMMQYYYCSRARRGVEYHMATRAVKFIRDQALTAIHNFEHENIEPDKHRGHATGVAQTATQAVRKILGGGDGGPSTSVESSPEPLFHTPDNRDPMKGWSKGVSLRKGHFCLLLKPQLVLRSETSTESVCVLTAVQGNLQTYHIMDDVNADDPVSGKIMNRNFASLSGLQAFSPSVENKSQEGVVPLEVLVDLRGSSSLFDRLVPQTNATFHYDKFNRLRLRNEITSVARTSHDGNDQMHNHLQSQNDLVRFHVPRFTVSANDRHFQAISNIVTNLLLFSDAAHKTRAERLEKMLFSYDFTNLSSAADVVSKLQIRLRMAVETRRQAESKLQGRGDTGQIEKLKIEAHILLLAEELDYVFEAIKLAQDKADGQAAQKSALLLHASSSEISWHMLDRHDQLLAKLAVRDIDFRWLNRQDSSTVNHLEVGNLQAFDGAADAEWTEILSKYDEPSNHPLVKRKLFCVADWTVLPPVGGITIYEAFELVFHPLRLQIDSRVGSRIMEYVWPTRRKRVSHRADSATEVNEILPPPSQPSSPIAPRTPLPQTPLTSRRASADLPSPRSTDPGRLTVPALRKIGTSRSFSDIRKAATDSLQVQVPSLHRTKSTDVLLTLSASNSSGQISKASDGSNSTRLPSLRHEVDDAAVMKTRSSQKTFVWVKVSTLHLLLSIMKEDSFLCRDARIQTRDLEYRNQTWSFEELVDQFIPSGKNWKGWVKMAFSQPLVPVLPVARELISKTKWVNTKGHQSDIHRRGTASPRLPFIGPSREDSQVPTRKRTTSTLATVKNAPLYKTENFSSLGLTSEPEPLPPLPPEPDETGRRTGKRLFKVFKRRKSESKTRGSFESTESSSTFAENTTVTGQLIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMR6</accession>
    <name>A0A2R6PMR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v4603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMR6"/>
    <dbReference type="STRING" id="98765.A0A2R6PMR6"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR93708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35026" checksum="6E539E00B7062D82" modified="2018-06-20" version="1">MDDEYIQIASAANEGFNQMKNSPGAFWMDYFPILKYIPAWVPGATGRKLAEQHVPITRMMRDQPFYSAKNDILNGSATPSIVYNIIDRLQSQFSDSKSYTAEEEMARDVLALAYSAGLDTSLITTLVFFVAMTMYPDVQKKAQGELDRVLGSGRLPTFEDRDSLPYIEAIILESIRWMPAVPLGVSHRVLTEDVYKGYRISKGSVIIPVIRAILHLNSMLNFRVFQMSQNAWSVYSFHLKLAFGLLWIAFGRAMLHNPDDYPCPEQFNPDRFIKDSSLDREVLDPSVIAFGFGRRSVLWSNNYFSTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMW2</accession>
    <name>A0A2R6PMW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMW2"/>
    <dbReference type="STRING" id="98765.A0A2R6PMW2"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="530" mass="58882" checksum="526C98B73D4A84EE" modified="2018-06-20" version="1">MSRQPSPAHNSQMYHQQSLAPSTSKQRTRTYGVAIAAGAEDVKYQGKYRELKKKVKEIELRCNILRILYERLADVPPTPGRHPQELPSDHDPVYELPLGPPEHARVIDPNDHALQDYLRSNPNARIIPGPNGGVIGIVDPSGNTSRGHPVLPPHGIPLVQDYRTESGSGTDAGRQLPPLPAIREPHAEPLVPNSRSSGYHASTHSTTSSHHSHNPSSHHSRVSSSRQDLDQLQGEPVRLDTLPPVRSVHSRSSSLSGDGQGESRSRRPDLHDISIPHGHRHPHPHAQVPEPNLPPSPQQVHSPTHGRTHNHQRVGPGVHLHRQVERDPETTRQLMRERDIERERERERAIALRMRLAAEEEELRNSGEWQQEDPRLGAGGMARGRSRSDTPGSGGGGGSGVSSRPASGQSYERERSRPHANRVADLLVSDQDPYYDSRDYRMAGPDSTRGYPSDSTAHADSRKRSRHDMEIDEEDGRSIRSPVDRSGANSTEFPMSHETRGPKRPHPDDETMTQGHVSSVRDEKPMDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PND6</accession>
    <name>A0A2R6PND6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PND6"/>
    <dbReference type="STRING" id="98765.A0A2R6PND6"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="158" mass="16764" checksum="B3CEDCB521F8E678" modified="2018-06-20" version="1">MSSLDKDKGKEVEEEIGETAGSQTETSDVEEISTGDATLPEASTPSTSSKKKKKKRTKALKALNALRSNKSDSIPQDLVNVVLEKVKETGGAPGADEATVRAALEQMKIKDVIQGKAGIGGINKKDTGGHKVRLSLLSSNVHSLICRNSSGLHNLFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVW2</accession>
    <name>A0A2R6PVW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVW2"/>
    <dbReference type="STRING" id="98765.A0A2R6PVW2"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1250" mass="136571" checksum="1D45B9B86EBC6F20" modified="2018-06-20" version="1">MPPTVSKSSGKIVIKPPQRGRGRGRGRGAFASASASSSSTIPAATRPTIRIGPRVVAAAVTRQETPTENQDGSDSASLPPLGEEGEQSSSLTSNAGESGALDFTPQEEEVGVDDGEEHEETQEENIKEEGMDVDVDDNNEGDDGVSEAVGEDGDVAIVSTPKEAGDEGEGEEPIPVRRGRGRPRGRGRGASVSGSSTPRTQPRGRGRGRGRGKGRSGAGKRKGEEGDGTEIGEEGEGGEGGEGGGKPFRRIQGQVYIIDGDEFITEGNPKGDEKIDPDGNLLGGRQFKAQTFTLPNRHPTRKYMLAIDAARTSGFRDSLYYFRRNPLAFKLNANQWEKDHLIEIGKLGSHLRTRSVTLITARSAYKLHGAKMILEGRWVVDDYNEEKVLAEITERGLKPGDSVGELVDTSTIAAEAAALAGTSTRDAGKQDRGGPSGGTGIYRAGGPTTIFGGSGWGPYSDGPLNAVRKSLLNREGLNEENWMWMTAQRTLEAGDEWKKIRQEGLRACGGILGEEDIVSEVEMKRAMDEIEGEDGEGRNSSKKRKIERDLPMGVYEPQSGIVLYRSDTQPLRSRWEVVHDPGKHVLGGTKAGNGAWGVAWVDTVMELPNPDEDEQMRLQAMKLILEESEREETFLTYESTNKDTNNVRASDHVETQFLPPRRSPPAIALFSSDFEGMEPSGTPLDHTLPHHPGLHTLRTKLQDILKSISSFGPTVPRPPVIDSSFDLAGNPVEDSQRQDAVRGLRALKDSVKRDLDVLEKVSHSSLVPTITKNSRLLAEFREIDSYFTDSEEESDAEDILPSLAQTEFDNSILRMGRSLLAAARENPIPGTNEVPAVTLRLTRLELSPSNEKEHDPRIAQTIEELRVLGIDVQLGERKDAALLQPSNGVPARLRRRIPTTRINLDLSILIALVSDLTHTTLPVSPQDANMRFTPSIQYVEWKNKRIASLNSGSVQNTQADEDRMDAADSDSVGRPSRALVHQVQQEMGKALFHDIFDRLSPVLCSVPSTAFPSVEFWTTPEAKERCLQIVAKIGGPKERSRADALFCVADVIEAEQLYWRDSRYPLGFIPLLPIRIFPTDDPEQNLRAPSFTEDGMSLSPFFQALARTCRDVLVQETIPHPRSARALPIATPKDDDYDPGEIQRANVTKANPRLTAHTVQSMLWGATKGWTTLTANKTSVKAILREMKAARNGSLWDRGDESDRVPPSTDAALGLANGTALVRDDFEVAAIWQVDPRSLAEGMRSDCEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7J9</accession>
    <name>A0A2R6Q7J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000383">
        <property type="protein sequence ID" value="PSS03716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7J9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6308" checksum="79FD4766DCCA5E6B" modified="2018-06-20" version="1">MVSALLKDAAKDEFEGLFEAALGTPKPVSASTRCGGCQRESLSGPGINEALLAWQSSLIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBE0</accession>
    <name>A0A2R6QBE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBE0"/>
    <dbReference type="STRING" id="98765.A0A2R6QBE0"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="20417" checksum="5EADF60C53FA3123" modified="2018-06-20" version="1">MASDVPLTFNRIVDFHRGAVHIAHRTFSHIEALRGITEFSTSKRLRSGCTAKAQGNVDKVVVVIKSKDDVALERFIFAVQNMIEVEAFNKDTSVLGAMSSVVLGQYFRSFLVKLCMVESQLGHLCLGGERLPLYDVTFAIVLELRDDKAPSLTHGKLSLVVQESEQKLLLGKENDRKGKEREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBH0</accession>
    <name>A0A2R6QBH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBH0"/>
    <dbReference type="STRING" id="98765.A0A2R6QBH0"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015350423" description="Cupin type-1 domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS05482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="329" mass="34337" checksum="BCAD592BB8F3DBF7" modified="2018-06-20" version="1">MSGIFRLSILLLAALSSVDAAPAFAVGSDSAAPLSADSDLSLTSSAASAASASPTVAFASDNPNPLLWTADSDIIPEAIRGTLGATVIGPQNVAVDLQNADFLAPPSTDAGTVCCDAYGNRNGWSQYAVGSGSYSNTSDLWYFPAGTPHSIQATADSPDGSEFLLLTDWLAHVPKDIIAKNFHTAQSAFNNIPGSELYIFPSTPPADNAVAPISPQGTASLPYAFSFSQQPATPLAGGSVKIVDSTTFKISTTIAAAEVTVEPGAMRELHWHPTQDEWSFYIEGTGRMSLFAASGNARTFDFQGGDVGHFVENTGNTTLRFLEIFKSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBL3</accession>
    <name>A0A2R6QBL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBL3"/>
    <dbReference type="STRING" id="98765.A0A2R6QBL3"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS05528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="341" mass="37653" checksum="90629FC36907B8CA" modified="2018-06-20" version="1">MTYSASNYVLVTGATGFIGAHIVDELLRRGLTVRAAARSQSKANQMIADRPQHQGRLDFVFIDDLTRPGVFDSAVKDVDAVIHTASPVTFDAIDNENELMLPAIQGTKSMLDAIKKEPSVKRLVFTSSFAAVFDASRGDAPGLTYTSADWNPLTYDEGKQGEPIIGYRVGKKYAELAAWDCIRDDHPHFDLVTFCPPMVFGPVVHPVPKVADLNETNAILWSVAAGKRPLPVSRVPCWIDVRELALAHVEGLLRPEAGNRRYTIAAPDHFSYGRAAHIIRQEFGWAKEVVVEGDGGALPDAFYVDGETASKEFRIKYRSFEETVVDAISQFKDIQSREQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBQ4</accession>
    <name>A0A2R6QBQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v3730</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="MLYV02000366">
        <property type="protein sequence ID" value="PSS05560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBQ4"/>
    <dbReference type="STRING" id="98765.A0A2R6QBQ4"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="278"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSS05560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="826" mass="86187" checksum="131DEB926D696672" modified="2018-06-20" version="1">MTDSPFLTPQTHTSELERPYPSYAYGATNFAPSAISVGPSVETPQSTPRGSTAYNAYPDRDGTSTPNLNNNAPLLVGGERDPSAGLYDPYTANKEQEAYDAAERASRPFYRKPWFWMLAAAVVAAVVVAVVVPVVLVAHKNGKSGGSASEDSSSGGGSGSGGGGGGAGGGKGGNLATSGGDGSTVTMDDGTTFVYHNSFGGFWVSDPANPFNNSAKANSWTPALDEEWTWGSDHISGVNLGGLFVLEPFITPSLFQAYPGSVDEWTLSTQIALANANGSNSQNLTQVMENHYSTFITEQDIAQIAGAGLSWIRMPIPFWAIETWADVGQDTPGGPAVAEPFLAKVCWTYILKVLQWARKYGLRVELDLHTVPGSQNGYNHSGKLGQINWLNGVMGVANAERTLDYIRAITEFISQPEYVDLIPMFGIVNEALLTTIGKDQLSSFYLQAYNTIRGITGIGQGNGPYMVIHDGFTGLAQWANFMPGSDRIALDTHPYFAFDGAANSAPIAAPATGGDGTMLGGPWPLQACNAWGPDQNNSRSNFGVTIAGEFSNGFNDCGLYVRGVGTPPMYSGDCTPFMNSGDWNDTMKGGIMNFALASMDTLEDWFFWTWKIGNDSVTGTVQAPLWSYQLGLENGWIPTDPRKAAGVCASLSGQTAPFVGTFSAWQTGGSGAGTIAPTATTDFAQFPPTTIAGVPAGQVPLLPTYTQTKAPVTLPPPTFTASVTASIGNGWVDASDTAQMNTAVAGCTYPDAWNAIASPVPTAACGSGGVATVPTAVTPAALPPASSSVSAALPPASIPATSVALTSDPAAVPTVSNIVAVPPIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEG4</accession>
    <name>A0A2R6QEG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000361">
        <property type="protein sequence ID" value="PSS06534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEG4"/>
    <dbReference type="STRING" id="98765.A0A2R6QEG4"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="23168" checksum="B8E542ED23687843" modified="2018-06-20" version="1">MDFNVYDSEDPPSGDEEARRRSDAIDEDLRTIDRERPSWRPIVYSNILKAIRNILDALDRSSGLPSPPIAASPSLSESSSGSSVAQADSPWSPELSRLRTRLLPLVASEDALASELSGGITVSGGRTGVYVRAGWQALITPNRAWPLSDIRAAASRPSVVTNLVATTLSATQDEILELWHYPAVRKLVATNKLRLEESAALWVPHFTSVYQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF09</accession>
    <name>A0A2R6QF09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Delta(14)-sterol reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QF09"/>
    <dbReference type="STRING" id="98765.A0A2R6QF09"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS06840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40491" checksum="EF7B06FC52C4CFA9" modified="2018-06-20" version="1">MSVAKTKADLNPRTQGYEFLGPLGALFITLAVPATTYALYFGCSESSGGCPPALDTLWPTLSSSLSDPEWWQSLWDTKASLMYLAWYAFCVVAYFVLPGDWIEGTQIRDGTRKMYKINAFSTFLLSMGITFGLIWRFGAQSFTFIYEHWVGFATAALAMSIFQGLACYLTSFHGDKLLALGGNTGNPIYDFFIGRELNPSIGLFDVKSFNELRPGLILWALVDISLACEQAVRRGSNITDSMALVLFFQLLYIADGLYNEPAIFTTMDITTDGFGFMLAVGDLLWVPFVYSLQARYLVSHQVELGPVWCAIVLVVNFTGYYIFRSANGEKNDFRNGKNPKTYFTVLLIHRELRDEENCEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXM3</accession>
    <name>A0A2R6QXM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000299">
        <property type="protein sequence ID" value="PSS17121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXM3"/>
    <dbReference type="STRING" id="98765.A0A2R6QXM3"/>
    <dbReference type="OrthoDB" id="3271139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS17121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="519" mass="58136" checksum="A5CEB66F4E9B3EBF" modified="2018-06-20" version="1">MTPLHDNLKDLQYDIKVQTHDGEEVYRTVTLLSDSGAQSLHGRGTRVWKVVRVKDGEAVGDPVVLKDSWVDLDRPREGAILQEICGMAASEPVDKTLSDALLTVECYGDVVIDGDGDRCIDRTTRMNLSDLPTHGSDTDTVVIKLLLHCHHKVHHRVVFKEICQTIQQLVSFHDKFRVLGQTSIILKALHGFGWVHRDISSGNILMDSFGRAKLVDLEYAKKLDGGDSVAETQVGTSKYMAVEVGARGYRFRPPLDLPPIPKDYILRSTDFDSISEGDSALNIPPPPRPILPIPIRGPVTPFRYNPIHDFESLWWLATHFMLKIEALYINEQGPPPARSLDELREQRNWSLFLSYDRTERLIALSDSDKFQEILCSLHPSVKPYGLALDTWRSRITCAHRQAQQTPILNADAAMRGLYDAFSQDLFTMANALARKTVVTEESEKERLAQLTAAAEVQGTSATKRRLDTQIESHEDDRNPGGIDVATPPHKKARIVRPVRAILVEGPAARTRSRTKANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R110</accession>
    <name>A0A2R6R110_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R110"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5812" checksum="D3A94A6ABF8DBBE8" modified="2018-06-20" version="1">MENVYAKGEEERAPASRIQINKILLVDLETADRTWDALLRGSLEFRQRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R128</accession>
    <name>A0A2R6R128_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v3158</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R128"/>
    <dbReference type="STRING" id="98765.A0A2R6R128"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000176">
        <property type="entry name" value="Isoleucine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="21"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="698"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS18942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1078" mass="124092" checksum="C79F6B0D943B1A14" modified="2018-06-20" version="1">MSFPPHDLTTPFNFAKEEEKVIAYWREIDAFQTSLKLSEGRPEYTFYDGPPFATGLPHYGHLLAGTIKDIVTRHAHVSGYHVSRRFGWDTHGLPVEHEIDKKLGITGREDVMNMGIDKYNAECRSIVMRYSSEWRATVERMGRWIDFDNDYKTLNLPFMESVWWAFNELFKKGLVYRGLKVMPYSTGCLTPLSNFEAGQNYKDVNDPAVTVAFPLVDDAKTSLLAWTTTPWTLPSNLALCVHPDFTYIKIYDEQHDQNFILAEGLLKTLYKDPKKAKFKKLGTFKGSDMKGWRYVPLFEYFTEQFEDKAFRVLNDTYVTADDGTGIVHQAPAFGEDDHRIAIANGVLRAEEMPPCPIDDAGRFTKEVPDFAGQHVKAADKDIQKVLKAKGRLIVQSTLMHSYPFCWRSGTPLIYRAIPVWFIRVTPIVDQLVANNKETRWVPQNVGDNRFGNWLANARDWNVSRNRYWGTPIPLWASEDMEEIISVGSVEELERLSGVKGITDLHRESIDHITIPSQCGKGTLKRVEEVFDCWFESGSMPYAQQHYPFENKELFESTFPADFVSEGIDQTRGWFYTLLVLSTHLFGRAPWKNLIVTGLVLAADGKKMSKSLRNYPDPNLIINQYGADATRMFLVNSPIVRGDNLRFREEGVREVVSRVLLPWLNAFRFFLGQVNLHRKTGDFEFKYNPHATVSNNVMDRWILARCQSLIKLVREEMAAYRLYTIIPRLLELVDELTNWYIRFNRRRLKGEDGKEDTVAALNTLFETLFTLCRTMSSYTPFLTENVYQSLRTFIPEDPKAGDTRSVHFLLFPEVKEEYFDVIIERQVKRMQTVIELTRVLRERHTLSLKTPLRELLVFHPEQEWLDDVKSLERYIQSELNVRDVIFTSDESLSGVKYRAVADWAVLGRKLRKDLGRVKNGLPKVSSEDVKKYIKTGKLVVDGIELVEGDLTVQRYIDLPEAAEAQHATNTDNDVVVRLDIQVHPELTGQWLARELINRVQKLRKKAGLQATDDVDIFHQFEGGEGGELLTAMKEHEETIKKTVRGVPQDASRRKATQKILIEEEQEVSDVKFILSLAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7C0</accession>
    <name>A0A2R6R7C0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7C0"/>
    <dbReference type="STRING" id="98765.A0A2R6R7C0"/>
    <dbReference type="OrthoDB" id="2527864at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="68004" checksum="F87712393268342A" modified="2018-06-20" version="1">MGDRCVACGDQTIYEEELGSSICTSCGTLANPTQQVLASHLEHVDTSGHDYSFYGSGIGGSTLKGRNGWALAGQDKEGRDRRNAIAMHEFIKSIAGRLSFSGSATRAQAVFDQAMSKGGLRWGRKAKLVAGASLAVALRESHKSDSLRDIAYLLDEPYVALTRAFTNVIDLLKLQVASADPAQHLTILENHLRALIQSATTTKVSLPGQLHTVLTPLVPRLSAVRQTASSLSTMIMRIPTLASLPTAPTACALFMLALEGELSGSLPLAGALAQALGVRLGASKAVVMQRYKSVYDAVEECIREVPWLDAHERKSNGKGRSKVAKRVVVARGLNDVVQFQEDIWRKKFESMQRPILTLEIDDTEDTEAGRRQEGYISGCAGGTSNTPMTPIPNRGHVSRSQPKKHPRKSVHERNIAQTSQFLLNPLGEVCSRERSRGEAREDLAQHFLTADTSALSETFVRPPTRLQLLATSRGGGEEDQIEDEELFEEGELEGLLRDPEEIETLRVALDWRHEDTDVMNIPEKTKKKRKREPTEQDDRVGNIKRTKRIDMDALARLLDPSTHLDDQEDHDPFDTAEVLGEAEHSGGQPCVFADGEEILEEWRPLSPGGGYDEDRYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIB5</accession>
    <name>A0A2R6RIB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIB5"/>
    <dbReference type="STRING" id="98765.A0A2R6RIB5"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS29767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="419" mass="47375" checksum="90F5EF1796EA2FE9" modified="2018-06-20" version="1">MKTADDTPSVQHGSLDEKADESTMQISALDIEDKDEALKLVGLERTAGIDEERFLKVRRKLHYNLAALAFYLGFLIWVFPTMYISQKLRLGKYLGTNIVLWGIIMMLHAVPNSFGPFFVLRILLGMLESCVSPALVLIISMFYKKNEQARRISWFYFTTGIGNMFGFVAYGISFDMRTGFAPYKVLYLLCGAMAITVGIAVLIWMPDSPLHARFLSQEERIVAVERVRDDQGGTENKRLKKEQLKETLLDVRTWLIVLSTLIRPGEQGPSSLRSVSAQSALKSPHSIPMRHLLAANYIVLTFGSCFGVIYAYNASNTSGHTKKVTLNAMTLAAFCVGNIIGSEIFQAKDAPHYIPGKVTILVLLSVQFFLCFLLRWVNLHMNAKKKQFIEEMKERHSWSDGDIAKERERHAFLDLTDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLP0</accession>
    <name>A0A2R6RLP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000231">
        <property type="protein sequence ID" value="PSS30950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLP0"/>
    <dbReference type="OrthoDB" id="10261040at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="204" mass="21577" checksum="245DF0598A601583" modified="2018-06-20" version="1">MSDDLKLSHKIIELSGIPSTSISSIYATRSALYQGIKTSHTTIPPDLIVLPPSLPPPPTDAADFLTELTACANAAATSAACGSILAGHNSETDEFGDIAFWLGPGSYEQGNELAVLRALDLPVGSHPEIEPVELSPSTRLPTSAGLTMTTTATERLVGLLTRLSNPHGFRTKLTRPEGDLIVYILAGQRDAGWMGLLGLGMWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM19</accession>
    <name>A0A2R6RM19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v2398</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM19"/>
    <dbReference type="STRING" id="98765.A0A2R6RM19"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="127"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="249"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSS31066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="392" mass="42878" checksum="63B7CA4C03EE93DC" modified="2018-06-20" version="1">MPSNGHAQTALTPGHFLFTSESVGEGHPDKICDQVSDAILDACLEQDPFSKVACETASKTGMIMVFGEITTKAQIDYQKVIRETIKQIGYDDSSKGFDYKTCNILVAIEQQSPDIAQGLDHGALENIGAGDQGIMFGYATDETEEYMPLTIMLAHKLNAAMAVARRTGAMPWLRPDSKTQVTVEYKHDGGATIPLRVDTVVVSTQHAESISTEELRKEILEKIVKKVIPAQLLDERTVYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYTARWIAKSLVSAGLARRALVQLSYAIGVAEPLSIFVDTYGTGKKTDAELVEIIRNNWDLRPGVIVQQLDLQKPQYRRTAAYGHFGNPDYTWEKVKQLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ60</accession>
    <name>A0A2R6RQ60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000192">
        <property type="protein sequence ID" value="PSS32162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ60"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ60"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS32162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="222" mass="25529" checksum="80741F29B8CBED78" modified="2018-06-20" version="1">MSHGKQFTLYTHASGPNGWKVAIVLEELGLTYESIYLDFQKSEHKAPEHVKFNPNGRIPTLIDHKNNDFVIWESDAILLYLEEKYDPENKLNVTTEEDKFVLLQWLFFQASGQGPYYGQAAWFTFFHPEKIPSAQERYKKETLRVLGVLEGVLSKQEWIVGGKPTIGDLSFVTWNQFALNILNMDEGFSFQQEFPAVSAWHAKLEARESVKKIAEIKASVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQB7</accession>
    <name>A0A2R6RQB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000185">
        <property type="protein sequence ID" value="PSS32207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQB7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="110" mass="12796" checksum="87D6DEB0F35152F5" modified="2018-06-20" version="1">MGWALGWPLPLKETAERARRCGLAKKSWSDKRAREEVMMEIVRWPDSRLIQFVACEVDNRIVCTVALCVDEDAETAEEAKPNNLPPLKVAYRIIDLLDTDRDLQWYKDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVW3</accession>
    <name>A0A2R6RVW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVW3"/>
    <dbReference type="STRING" id="98765.A0A2R6RVW3"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="955" mass="105710" checksum="B0E6E00679168099" modified="2018-06-20" version="1">MSSIQTFLNMRSIGSSIPTDGPLPDSLLPLNISRNFDPQSLISAFGWKELTIGEWLRHVLDPDVSKSNAEYDLTLSPTWAERVLNVLARVWPACPRAVQEDVINLLKDKICIPTSAGLRTPQEAYFQNAHVFPDLPLITLPSGAPVKGPLEKFVQALGVRKHVELQIVFDRMLKAGDWSIVDLIKYLVAVQSTLSSEELDRLRLTPAFPKENGNADATSDKTRKTRSRAEHLYEPLDVFKELGLPVIDWGSKKWRGSSEEAKFLFLLGLRRFPPLDTVLGLAAGPDERIRGLALKYFLDNFAARYSDYQPASYSQLAFIPALKGRAPCMAKPGEVFASSTWASLGFMILNPNLQADAATKLGVKDHPPASFLVSLLEKSPPETEDVARLWFGAMATRTTDFAPRDLRSLSRLLIVPVTTLKDGEAKAGSAVRLIAPSQCYFKRDTNGQIHSKLFTFVDFGPQANQFLSACGTKHEPTVEEIAVILLEDPSRFWELADGRDNFLIELRNIAVNHRLLSPATLTRMKQGPIFLGSRRIKREKFKSKESSADLEEDENWEYEYGLFTPDKIVIADDTNAYRVFGDSIFACPQEDLLEDFYSEVGSRRLSSMVEEEYRTTTEIKGSRKAVEIRSLILERLPLFLHEHTHAKPRVPFSWLNNNTNFVVRTFGKLTVTKSLTYGEVRAVRNQDSSAVAMRVGRGPIELWLAGNDLVDMFEVSTSICRLLFDSPRASDALLFMTILSTDLRALRRRGYNVDRILQKQKTAAEDAARERAQQTALVPQDVLLAMAHASAAIDQRPGSPSSESALDNDVGLGREKIQPPHWMPKGNLKDNLDSWKRMLTSKNGSRPVSVPVLGAGSAAEPPSDHQSISSAPIPESANGSPSPLPPPTTPAPLLLSSSPPHTKTQAPLLSPPRPTASRPVTPAPLLSPPRPTASRPVTPGPTVTPRDHIGKLQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVZ2</accession>
    <name>A0A2R6RVZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000143">
        <property type="protein sequence ID" value="PSS34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVZ2"/>
    <dbReference type="OrthoDB" id="3257375at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="246" mass="27321" checksum="B5E7AA813225089D" modified="2018-06-20" version="1">MQPQNTDNPGVQGLAPNELPQHVGNITQYVVDQAFVSSSMFRTHALTGHDLIGFSDRKQLKLKETPRKIGTPRATQNVTTQREDIVDQMENEMVLCQGWDETGFGHYLPSKHPVSDADVDAAVDALKQAGHLELDAADGDFQFTEIDPTAHGNETVIYSPLVKICEVLQDLSFADKRQVSCKIEQNPNNYNESETLGANFKVDAYLKLAHSTMPKNKDLGPVCDLAVPSEYKRDRTNVYEVCVSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW04</accession>
    <name>A0A2R6RW04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW04"/>
    <dbReference type="STRING" id="98765.A0A2R6RW04"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS34175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14253" checksum="D14B30BD5173B9E7" modified="2018-06-20" version="1">MVRVSVLNNIVNAERRGKRQVLIRPSSKVIVKFLSVMQRHGYIGEFEIVDDHRSGKIVVQLNGRLNKTGVISPRYNVQVTQIENWVNLLLPARSFGIIILTTSSGILDHEEARRKNVGGKLLGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3U1</accession>
    <name>A0A2R6S3U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3U1"/>
    <dbReference type="STRING" id="98765.A0A2R6S3U1"/>
    <dbReference type="OrthoDB" id="3270670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="35388" checksum="3F84401D0062FDA8" modified="2018-06-20" version="1">MHSNPSYWRPPLCPQSSSHTSSHIASQPTAPSLIHPQPYSTWEQSRESWSLPTSYSFDHTDDFATPSSSYEPDYLKIAHLSDSYTDVPDSRSGSSASQLSSKPKFEAASWGNNLYRLEPDTESVQDTGPVTQVKQEEMPTNPIVFDTPCLGRDASIHAPKHEVPLRATQASPEMRILMGCFRLNPFAEQNGRRGTAATTSWSGEEIGPLREPPRFIDFQLEIPHAASSEPDLPPRRSMPSPTPPFSPPESLQYSYDEEDEEEHNWSSPPAAYSSLHVVPEPPVFEPVMTPAQGLWQMSYQPQGSTDGSSYSLSPPASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4D9</accession>
    <name>A0A2R6S4D9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4D9"/>
    <dbReference type="STRING" id="98765.A0A2R6S4D9"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015310047" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="40111" checksum="A7C594933052DE25" modified="2018-06-20" version="1">MKFYILLALSCSAVASARFIPVRRANSSLQSGQDAIAQNAQFASFTADTPCSDSQFPLACVQGSFAQCVNGKYVLTACGATLTCAALPNVGSPGTTVTCVAPADRDARIAATGATAASSGSAASSSSATSAAVAATSSPAAGGNNAGQGGAAGNKGANTTSTDSGDPQTSLTLLSSVIAKGFENNGQDQPTQGQVASLTSSNNFINFCATVPNLPITNGQQIKTGSCNPAPMGIIAATTNIPSAKFVSPKNGATIAANQSFTVQLAIQHLEAGHFVNADENYFAAPQQVNTAGDIQGHSHIVIEKLSALDQTTPTNPTTFAFFKGLNDPAQNGILSADVTDGLDEGVYRLASINTAANHQPALVAVAQHGSIDDMIYFTITKSGAAAAAAGAAKNGTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4U4</accession>
    <name>A0A2R6S4U4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000068">
        <property type="protein sequence ID" value="PSS37282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4U4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4U4"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="568"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="774" mass="86451" checksum="B7CB7240472BA102" modified="2018-06-20" version="1">MSSCISDLSKEDEAIFQHLQDALNRTGHICSEPDQQLLQALEDMIPVVITSIFDPLLALVEKHPDLSIMRTLLKDTKLAWNTIPLGTIPEDVEGLCIRSTILDSIYFWTLQARSMVDDSDRQLPGLQTYPCICLKLAIIYSRIALARDKNPDGRGHFDLACLLKKQSERHGNEEVIEEVVVMFREAYKLSPTREMLHPLVDSLLARFSASGAISDIDEAIDLMRQSEERKVSEDGQIILCDAYRTRFSVCQNPDDLTVTLSIIEKALPDGGQARTPEQYWGRLMSISRTIPAGTMNTEQGTLMLEIYRKLLKLLHSVSEPGLDLELSLPRLLSFEGLPSEAAAHALSLSLPEKAVEMLEMGRNLFWYQTRQLRTSFDGLPTPLADKLRKYARLLETTINARRSADVYKLRKMQDKFRHLLKKARRIKGYENLMKEPDYTFSSLAAAAEKGPVVVLVGADVSCHAVIIRSPSSSAEHIKLSGVSLKQIRNMTQKLKKIATRSRECIREGSEFIDDISRAGKQSMPATEDLLRTLWVKVVKPVIDVLGYETLGTLCNAREGLDSVVLSGPKALLVAEPDAPKLERLPNVIREVKTLASIIPPNAVIHLGDEQVNDWLPEHGTSVQAVVTHLPEASILHLACHGIQHDSQSGHHRYATDALRSGFCLRDGDLTVFQLLRLDLPRAFFAFLSACHSAKGDASQSDQRLIPFRLGFAARIRSMGDQDGPEVAAGIYKELFKGETMDPDDVPYGLDEAVQKLRARKVHSSRWATYIHMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Y9</accession>
    <name>A0A2R6S4Y9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Y9"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Y9"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="169" mass="17789" checksum="934A4ED783E4BC27" modified="2018-06-20" version="1">MLAPSSLDSSDTSRFNPIFVLPVFSPVNLTTGSSRTSTPVTHTPGRRTGTGSAAVSSPSSRPPTPQSNVLGFRTASLFSILSASGNVPGGYTDGEEHSSLEDIRTKAGRPVVVFPECTTSNGRGLLRFANLFVGVDVPIRPTNELVPHDVTFNLIPYAESVVACLQADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5N5</accession>
    <name>A0A2R6S5N5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5N5"/>
    <dbReference type="STRING" id="98765.A0A2R6S5N5"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF2">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="98"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="963" mass="104624" checksum="89273A072BD7B0AD" modified="2018-06-20" version="1">MDAKPLPPPARDDRLPPLPPSHYDNSATSWDVSPPPPPKHTLDREYDASQYNTRGHNLPDIHSSALSPHDGFDVPPITPISPVGSTPSSPSGDAKSKKKANPLTDLIETEKVYVDLLTGIIRKVAAAWSRSNLPPPELDTMFRSVESVYKANRSLLSKLKEIGANPSSPKALGDLLMRWIDDLEAPYTKYATNYCAGFDEWDPVQSNTRLRTTLAIFSSSNPPPLPSSSPEHPPEPPLWTLDDLFLLPKGRLGYYRKLYSRLLKSTVPGRSDHRLLSGALDKLDNLLVTLDERAILKVGANTQAPQDTEDEVVFDMRTRQSTVPLNSQTQRESDSTHGSGSIANDDRLSQETPPTSVERTSTAAMSIPITDLERRLSTEQTLDIFTMQPKQVRLQIAPPTLHYTRDLRICADVVMTFTPRSTGVDVTHERGRIFVLTDLLLMCERMTPREAARFTPEGPDMWLLYPPLAGKHLRVVPVDGSDNAFTVTILRKEIVTMYAESRQLRDRIVAEFRECIDAAATLVPAKNQAPPPPVPKLPSGGGGLPTSPTALRGPSDMFSEYPNMSSILPNHPSSPSNSLPRMQSPPVNGFANMNISEDPHARDMSRMPSLSNAMSGSAYPPRSASMASPDGPGPYHSPIENMSGQGFGPGQMMRQGSFGPGQVMPSMNPGQTMPHQQFVPGQIMPPPRGASYGAGAPDPSVAGPRRSGSTYSENLPSSPYGPPGSMRGMSPYAPSMSRPSSDGSGGPALRKSTSSRSLASQYDSRQSNGPLPPMPAYPDGLIPPSRPFLPRSDSSSSLSSLPSLYAPQARPLLPSAQYSVRSMSTGPSFIDPSPPSSPVEETPKPTGPVTSRVSEQMKCKVFLQEHHAKWKSLGSAKLKLYHESPTNVKQLVVQADSKQNVLISTIVLEDGVERVGKTGVAIELSDKGQRMGVVYMLQLRDERSAGSLFESLLAGSDRSEVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5P1</accession>
    <name>A0A2R6S5P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5P1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="13913" checksum="7A755A654795FA10" modified="2018-06-20" version="1">MSGTKSTCSSPTVLGFCKMTELHCAGQRKEKADSSKGPQALPFSPQPSFGSQYVDVQSIKASVGVRKDCAREKNAKPMMYATVRRTKSQGDLKGRVIRIRAGSKARLWERRPVYTVKFRKGTGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S721</accession>
    <name>A0A2R6S721_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S721"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS38055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="387" mass="42154" checksum="062207939E7792C6" modified="2018-06-20" version="1">MEKPDSKYCLEISVSQIEKAEPIRPSRWRDRVQDWGTGSTAFLYTLWGFWWLDCVVSCSIAFGLVYIMMGQNSREMSKVGPVWMVPIITLITISSSGGLFARAFLPYSHTLALLSSVLSVTMLLIGLSFTMMFTTVFLLRLYLYGPLEGTAVLTTFTTLTPLGQGGYSMLINGQDLSELLPDEIQETLAPATAGAAAAPLVGKFIFSVCFCAAYALWCMGVAWITLSCFSIIRRAHTLHTLPFCISHWCVIVPNGVFASLSLQMATVLDSPFFRAFGAVWACLVFILWTVIFLRSIPALIDGSIFNKPSPSATTTVTTSSSTASSAPMVTIDAPRSPIKVVLGRGESFSSEKSQDIESVVATLCYKKAQTAIEETSAGEHKDGSHSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S760</accession>
    <name>A0A2R6S760_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v62</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S760"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="861"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="906"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="511"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="806"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS38082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="942" mass="102278" checksum="88B0330A133F7D55" modified="2018-06-20" version="1">MNPSADNADNLKPPDVADPAPSHTKMDSYPPAHPPVDPHRPPGGTRRSGNKTPRKVQWVDNDEGAESSTRALDEHGLNPEPFETLKDALEKHRSQPSINTSEVNNVLRTVPTTDSSSLDSPTLDRTTTHTVPGETYIDKDETAGLPGTNDLEAYSQKRASQVVQAHKLGFFKSHLGFGASSRKPIKKRSKQNKGLGRAKSAEETDPETDVDVEHIAESSSSAVRPRPGTGVLSALLSLYDHERPSMSGMSTPARSSFEMDDSRPTSLYETMTKDSRSSFPFENTISPTPSMAELKAPNHPWTKTLTGGFGEKRPASARNAGGVFGALIASTGNLSAAASPMSSTLAPQVKRPGYKLSRYSLETSIPRLESAVHKERGLRRPQSMHFSPSETLTTVVTTPSSSGTSPSASAIFPGGSKPPDLVLSTGGLDTPGRQKWTGVLKDLPKRGWSRVGTPTASTPGTPNTDTDEWLGEKERVWDRDERKEKERKRRRKKAEIYITRHVAEIIQRQEFICKLTRSMMMFGGPSHRLQAQIQATARVLDISLSCMYLPDIMLISFDDASTGTSNIKLIRQGGAFDISKLQAAYKLYWKVIHDDISVKDASVELDNLMRKPPLYNKWQLIFFGGMCSASICSVSFNGSFIDSLIAFPLGCLLIVIQLFAAKHELYSNVFEITVATLFSFISAALASTGHFCYSSVAASSVVLILPGYIILCGSLELSSHNIVSGAVRVCFSIIYSLFLGFGLAIGATAFSKISNSPLQGQDDLTCSLSHHADGAWYQQTPSIRWAFLTVPLYSLWLSLRFYAPWNRKEIILLVAISCIGWVTNHFTGLKFPGQSDVSAAVGALAVGFVSNLYARFFNGNAFVVMITGILFQLPSGVANGGLFTFVSKQDSGQSSSDVYLSGFQTALQLVSVSVGLTVGLGISLVLVFPIQSRRRAGGVFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEA4</accession>
    <name>A0A2R6NEA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v13410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001334">
        <property type="protein sequence ID" value="PSR70717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEA4"/>
    <dbReference type="STRING" id="98765.A0A2R6NEA4"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="4">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR70717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="27529" checksum="C69E168BAD80C323" modified="2018-06-20" version="1" fragment="single">MSTAQLTTTLHAAQALAQAGGGVGRFACVGDISCDVEGGLEFLPRSSTLSSPFFRIHCGSAGSTGVTMMAVDILPTALPREASERFCAALVPYLRTVVRQYLTPVAKEGREEEEEKELERAVVASGGALREEHQWLEGPLGLWRDHQRGLSQSHRAAAAAQVGAQSDSRGGAADDESGNMAGGVRKKRVLVLGSGMVAGPAVDEITRHGDVELLIASNSLEEAERLTRREHAKNASALYVDINDKETVGRLVERADVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEG6</accession>
    <name>A0A2R6NEG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001325">
        <property type="protein sequence ID" value="PSR70770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEG6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="15298" checksum="F3DCA388C16DEFED" modified="2018-06-20" version="1">MEEAGNGRYRDRYRGSIVDITRLVEMHPVYCIVNVSGDREQWMNGVTKMPTTTGQEDNFYNYGLDHTYTQVSPAPGKTAAQASQVSKLWRKKLSRPTLQQGASTSLDGQVEDRFITTENSVFTELYEDMWYTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF27</accession>
    <name>A0A2R6NF27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v13299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF27"/>
    <dbReference type="STRING" id="98765.A0A2R6NF27"/>
    <dbReference type="OrthoDB" id="2755091at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR70858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29285" checksum="BF9056412A1E590C" modified="2018-06-20" version="1">MAFERTIQRYNRGSLTKDLFYYLSNEDQAETESPPRHIVISDGLIALIAGSDTTATTLSNVFYCLLTHPETYKRLQDEVDKYYPLGEDALNPEHHVHMTYLDAVINETMRLFPAVSSGSLRAPIRGTGGKTVGPYYLPEGTQARLHVYSLQRDARYFTQPESFWPDRWLIAEGLQKFSGQFVHDPNAFIPFSFGTANCVGKNLAMLEMRMVMCNCMQKLEMNFAEGWDSEMWLRDLEDVFVTRMGQLPVTIRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF60</accession>
    <name>A0A2R6NF60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001300">
        <property type="protein sequence ID" value="PSR70951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF60"/>
    <dbReference type="STRING" id="98765.A0A2R6NF60"/>
    <dbReference type="OrthoDB" id="2751773at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015323581" evidence="1">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="82" mass="8826" checksum="A0A47523E47065CD" modified="2018-06-20" version="1">MNTLVFFLVALAAVVSAVPVLFLRDVFVPPVTYPHAGTVWKIGQRHNVTWDTAGAPVNITNKIGRIVLAKGGIEDIGTLNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFH5</accession>
    <name>A0A2R6NFH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v13372</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NFH5"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015361140" description="beta-N-acetylhexosaminidase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="173"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR70752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="394" mass="42603" checksum="9F4337D445818F6F" modified="2018-06-20" version="1">MLTLALFSILVPAVVALWPVPHTLHTGSGALKLAHTFAVQLQAQESPPADLLAAISNAESLLKTDSFQRLVVGRASADDKAISHAPELPSLLLSLAPRMTLRSIADEATLALESRSESYQLTVPHDGSQATLLANSSLGLFRGLSTFTTMWYASPTQKYILNAPVQILDEPAFAYRGFSLDTSRNFFPVSDILRTLDAMCWIKLSVLYWHVVDSQSFPLDVTAFPELSAKGAYSDAEVYSTADVNNIVSYANQRGIDVVMELDSPGHTTGIAFAHPEHIACANKSPWSQYASEPPAGQLRIASNSTLSFALQMFDSVASNLKGPMMSSGGDEVNLPCWQEDEATVQDLEQSGTTIEDALNAFIQAVQAVLTARGKVPLIKSGGWMCLSTRKDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFV6</accession>
    <name>A0A2R6NFV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001305">
        <property type="protein sequence ID" value="PSR70882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFV6"/>
    <dbReference type="STRING" id="98765.A0A2R6NFV6"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF108">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="35621" checksum="4AD3E8A2CF81F27B" modified="2018-06-20" version="1">MSSISSTGGYILLASQVGGHPGVKTSEDGSILIKPALPVEVHFYQSVGSDPNLEPLRPFIPHFYGTLRLEGQVDPEQNVAGAIAVTKESAEAVNEAEKDIASEEKRARMEKTARETTSLETGIRLTGFQVYDLSKGVPINTPKSYGKSIKANDLPEGITRFFPLSNRSNPPVASEESADLSVAPHSEDTNVGTGLPADILLPILECLREDIAEIREALSQMHIRMVGGSLLVVYEADWDRAREGLKLLEDGDDEDEDEDEDEDEDDENVAKKPSPPYVVKLIDFAHTHFVPGKGPDEGVLLGVDTFLKLIDGRIEQVKALMNTKEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG25</accession>
    <name>A0A2R6NG25_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG25"/>
    <dbReference type="STRING" id="98765.A0A2R6NG25"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="266" mass="29269" checksum="14689F4BF1D08868" modified="2018-06-20" version="1">MHAPSAPILCSFANSDELVESLAHFIIKAQKESVQRKGKFTVAVSGGSLPQQLNGLIGKPGVKWDKWQVFYADERIVPLDHEDSNHNLCTTHLWSKVTIPKENVHTIDPNLIDAASASDAEDALEEIADAYEKELIHEFANKDSARFPIFDLILLGVGPDGHTASLFSGHPLLSEDDRWVAYITDSPKPPARRLTLTFPVINHAARVAFVASGANKADTLQTVLDKPEEGLPASRVRPITPGQVYWFVDDAAASKVQYPRTPFEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG35</accession>
    <name>A0A2R6NG35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG35"/>
    <dbReference type="STRING" id="98765.A0A2R6NG35"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="36109" checksum="909BB141F83FAA9F" modified="2018-06-20" version="1">MAQAHFPPHSNFDLSDFFSPINVSSESRARAFLWLCYHYHESPLPNPFDDEYSRRHPGQVPTLESLSPEEAKLENMDTPEEKEWGLRMKEQRRIFMENKDKSAQTDTDQPKEKTSRRRRKDRAPKSNASQKRPSAGTSKLIAERSPVDRASSSTSNLNQDQLSEVTMSHLRLLCDSHQSPPILPSMSSSSPEASYEPSSHTRASGRPDERYDHHFPSPFPAFLNSSDRHVEWTQSGKPRGPTLPPLKYVASYSEESPPRELPPLSIPPSPPMLVDSQGTPPTFCMPPDATPASSVSFRSQSRTMLERESMLHTFLYFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG87</accession>
    <name>A0A2R6NG87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001286">
        <property type="protein sequence ID" value="PSR71363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG87"/>
    <dbReference type="STRING" id="98765.A0A2R6NG87"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36476" checksum="6A6563EF407B425D" modified="2018-06-20" version="1">MASPDKTDVTAIVPSNLRAPLDETMYSLDKIELEFLTKLTGIRDPEDLKKHAIAIQAEAYEVCLKSKAAETSENLNMRLATGLSLSLYPLKISRLPAYKELLRVGKEWKGALFLDIGCGVGNDLRKATADGFPVTQAIASDLRPEFWELGHKLFRSTPETFPAHFIPGDALDPAFLKPVNIPMTAPTTPIPPLGSLTSLTPLVGRLSIIHASSLFHLFNEEEQLRLAKQLGALLSPRPGSFIFGAHGGRPEKGFRIAASRPDSHGVRMFCHCPESWKRLWEKEVFREGRVTVKAHLQEVERGDLLAVDSEGSKFHLIIWSVTRLPEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGM3</accession>
    <name>A0A2R6NGM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001282">
        <property type="protein sequence ID" value="PSR71473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGM3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="5615" checksum="2417B5482A79AB42" modified="2018-06-20" version="1">MPTLASFAGNMGESLGGNFAHAGGNMEVEALGGEVGEEDTNESSMRHSDDIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGV8</accession>
    <name>A0A2R6NGV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGV8"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="275" mass="30530" checksum="CA11A5670FF1E27C" modified="2018-06-20" version="1">MANDVAKAQLIDQFMTAVVYGIYLVTLGMTISVLFWGRMGQKRRNWPLILVMVLMFIFATFDVAFGLQHNLDAFIYYTGPGGATEAFEDISNWVNVMKTVDVQLMTLIGDGMLIYRCWVVFNHNWLIIVFPILLWLANAVCAFAIIVITATLRENTLIHVGNLKPWITSFLVVTLVTNLLTTGISFNLIIIRVDKGIAVGGNNGTYAETAPSIPLNFRRHPPNHTTTYDLEVSVDVSVSRDVDQDTDHRDLDTVDGGKDSVTVASGDADAKWQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHU4</accession>
    <name>A0A2R6NHU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHLCEN_2v12164</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHU4"/>
    <dbReference type="STRING" id="98765.A0A2R6NHU4"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PSR71954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13246" checksum="01E4EF8CFD8EC342" modified="2018-06-20" version="1">MSLLSTFSTNSINILAGINGSETSQALIIALSVILNDLLYLPWPFGFRIPLHLLGGQAELEVGGAWSAGMSHGSRELVERHLFSLYFMLPLVGVCAGFLYHNWFGLPLPILFIFISDFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIU4</accession>
    <name>A0A2R6NIU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIU4"/>
    <dbReference type="STRING" id="98765.A0A2R6NIU4"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="2"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="749" mass="81300" checksum="CD340FA3F9CA8966" modified="2018-06-20" version="1">MLFTGVAYSITAFPVLCRILTELKLLDTTVGIVVLSAGVGNDIVGWTLLALSVALVNAGSGLMALWILLTCVGWTLFLLFPVKMGLRWLSRRTGSVENGPTMFFMTVTILLLFGSAFMTDVIGVHAIFGAFLSGLVVPREGGLAIALTEKLEDMVSIIFLPLYFTLSGLSTDLGLLNNGITWGYTVAICALAYSGKFGGCTVAARYAGFTWREASTIGSLMSCKGLVELIVLNVGLSAGILSQRVFSMFVLEALLLTFMTTPAVTLLYPPERRVRVSATGANFNSVIDADIEDKSSVTESRLGDPDVKDLSPWKTRFTVVLDKIEHVPGMIALAQFLQPPPSTLVAKEDSKRRSGSRDVVIDALRLIELSDRTSAVMKSSVWDTLMYTDPLLGIFRTFGELNGMTVSTSITIDSYDDLASSVAQAAGRHGSQLVLVPWLPPYHSHPVEHHHHTSPPQTPMPTINPFDKLFGNDGPTHTSHSESALHSHFVRGVFSKSTTDVALFVDQHIPGDMPRVTTGASGTGGRFHIFLPFFGGPDDRLALEFVVQLCAHPRVSATVVRFERTDDLSQSRSIDKPEAAYLSIKEKGDVHTRENTSTVASRAFPDTVYGNATTQTRMQSETADNIIWLRYASPSSTESFDSVASSALSRIEWKETSTPTPLHSLVEQAAVLEDSTSERRSRLMIVTGRSRRLAVENHHVELKALIDQHRDGGVMQEVKKTVGDVASSFIVTGSKASIVVLQAANVSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJS4</accession>
    <name>A0A2R6NJS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJS4"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="116" mass="13352" checksum="4D46DEB0D5EFA016" modified="2018-06-20" version="1">MPGLVRLASRSPVAEDLEEALHIRHELVALSEGTASHHEHVLKLSHSLHSQYRRDPGQLSVFDEGIKQVRDVLRVQNGTKRADVLVFRYNRQRRLDDLQRAQAYRATGYDEPVTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK85</accession>
    <name>A0A2R6NK85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK85"/>
    <dbReference type="STRING" id="98765.A0A2R6NK85"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015318692" description="Cytochrome P450" evidence="6">
        <location>
            <begin position="16"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48515" checksum="04C62EB75513C8DE" modified="2018-06-20" version="1">MQLVVGLFIIAVLLAVILYPDRCIGVAARKDLSGPRGLPLVGNLLQIWPNRRRMIPLMEELGKKYGPLSTFTIPAWGRTIVINRPEWLAHVKQNDLKSYTRGSVAVSIFEQFPGHFTPVATEGAAWRASRKSIQPIFAVKSFQDHLVSAMDELDGTKSHFDKNISRLWAAIEALIAEHSDRKRSQDNLNEKTDFLTSLIQGHSEENPVFLRNIMVTLLFGGRDNTQNSISWAMYELSRHPQWLTRMRKEAMELDQAGGMPTFSNVSSYIVHLAVFYETLRLWPGLPKNARYAIVDDVLPAVPDLGLPEVPISKGTYVLWSDRIIMRDPTVYGEDAAEFNPGRHISPEGKFIKPSLPEFISFGAGPRYCPAATIVPYEWVCIWSALLRDFDFEALDLAERTVGDTLTNQMEKPFMVRVRLLDKQEQLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKT6</accession>
    <name>A0A2R6NKT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR72989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKT6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="153" mass="17172" checksum="603122D2B76F64A0" modified="2018-06-20" version="1" fragment="single">LSKLKNYIPARLRHLHPPNLKVPPIIVTIQLHNKAPSGHGLDVAPSWSLAVEPASSFNLGSRLELKAKETKVATTFRGWVSGVEELQTKSVVLRVTSSGKGKGDVMLHIPYHFVKLPWYTRKIGTFRAKFNLLPEGLPLKYIEKRTIEDPLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL10</accession>
    <name>A0A2R6NL10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v11147</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL10"/>
    <dbReference type="STRING" id="98765.A0A2R6NL10"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015334152" description="Palmitoyltransferase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="14">
        <location>
            <begin position="153"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR73043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="409" mass="45108" checksum="6103A07DEEE47913" modified="2018-06-20" version="1" fragment="single">PFLVVFCILLIMMLWAYVMVITTSPGKAGQHVEPSEAPAYDNPVPRWWDAEDEIGGGPYQYAPQGTNQNGGSSGLPTKPSPARLAEKGSQQDYNAGDTDAIPPVAAARTRAEVNGNEAANVPPNQTNGNQNTSGQLPMMFSRSPPQTPVLRPEFRYCQRDGFIKPLRAHHCRACGTCILKYDHHCPWIGQCVGAHNHKFFVHFCQWAAIFCMWTFSTLVAGTVKMSKNGGAVDAQTIVIIALSALFILFTTVLLITHIRLIILNQSTVDSLKAQHMKEREKSVLARMHSWYQFGGRRSNGIKNGVISIRKETSGGWEARGKTGKLSWDLAYGDGFYRSDTPRRMVLIGLSILALTPKVDGGHGKNGLRNCGDMTLAMYQVSKRIGPPLPRLTLFADLPFLADNMHYHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL56</accession>
    <name>A0A2R6NL56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001106">
        <property type="protein sequence ID" value="PSR73105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL56"/>
    <dbReference type="STRING" id="98765.A0A2R6NL56"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="9">
        <location>
            <begin position="142"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="298" mass="32831" checksum="4E5D0A69D0F72ADF" modified="2018-06-20" version="1">MLSRTCRSGLSLAVRCRAGFHGIPEPATLTSTEVPSQTLPDPPKSVGSASSIVNKSALQAAPVLTEKMEHEVASYIGEDVHEFLSDDHPALRAQVEKALKAAGIPDSDADITEAHIASTIVHGRSWVDPYCHPRTHGIPSAVLHLRSYHLPLLILFSHFAQHAASALGIPISKPTPLPVRRNLWTVIRGPFAHKKSQENFERRTYKRVIKAWDADHEVVDRWMRYMEKHVLAGVGMRMVRWDRAPVGVGHKIAETVKADMKIAQAETSQERIKALGEKILQQELMAAAAVPETKQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMF7</accession>
    <name>A0A2R6NMF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMF7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5793" checksum="6A14C949A5B24652" modified="2018-06-20" version="1">MLKIWVVLNSNPVPLKTVYLAKKARPIQVYHTTQNCMQALTSPQIPACVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMG3</accession>
    <name>A0A2R6NMG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMG3"/>
    <dbReference type="OrthoDB" id="2260578at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="224" mass="24244" checksum="1FFFCDF8BF91D363" modified="2018-06-20" version="1">MPPRVPDPPQSMPAYPAGTSRHRPSSSWQQAGTHQAYFSGGSHPYQQQGDWGNAPLAASATEAQLVPQYYGGAPVQTRTGRTYYSGEQFGGQATYDYQNYRDSSTAQPVSSSHPAYAGGPFPSAYPTPDMDMGSGDLTLSYSYSADRTMATNQTRLHPQQSGYTEQYQQGGNDVYRAAASGMVSNTSHQGWLSVSLGTKSFGISADTMYQDPNYLAYHPSLYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN39</accession>
    <name>A0A2R6NN39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN39"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="220" mass="25139" checksum="8A4E9ABD5975C7A1" modified="2018-06-20" version="1">MSKTDPIFIPRNTADSEACPPSTSRRRPQQLELFSTEDVENPLPSPPYRRVASQTYLHPYPEESPAYNSQSRLDLSTELSRMVEENEDQHPPSDKESEHIVDLDEHKPSAKTARFREDVQSPLATIHPLPSFVRAETFESTRSRSPSIADTDDERDDYDWSGEEDLVDEEAKFEQNMGVAKKESWGFRKYVWWKLCAVSESSMPSNGLGLSVLPMLIVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN42</accession>
    <name>A0A2R6NN42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN42"/>
    <dbReference type="STRING" id="98765.A0A2R6NN42"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26938" checksum="257FA4C16FE1BAB2" modified="2018-06-20" version="1">MHFHDTLPLTEEACELAESLELERTVDLDDRLALTVPYCPHLRAVYLTGVRDLTDRTVNLLARSTDNLTILDISGCRNVTDVGILELVAQATHLQIVRLNSIVGLTDPAISAIARSLPHLAELELCGLPMITAGSVRDIWTFSRKLKKLVLARCSHITNKGFPEPSSLNSSPTRRSGARASTAVATPQASHRNSEATRVTTSVSKGRIAYSGSRISSLFRASWTKKSSVDKKRKGEISSSHQGPMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN80</accession>
    <name>A0A2R6NN80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001053">
        <property type="protein sequence ID" value="PSR73863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN80"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="421"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="957" mass="108145" checksum="0F609A1BACE3E0B1" modified="2018-06-20" version="1">MLPVHLLPEAIKPLPNFKGPPPSPARTLCKMNTGGLPLSSHKKEVVHPYVREDLAETKYIPLYAWTQAVLGLSGRDIEERAAYIRRLRWFEDPVIRDALIAFCSTPPDTRREVGRYQPFADIANRAFELAKGNLPNVPESYPIHDICVVRNDPKSIRRIPQHELGADRSPDLLFIRGADKWKLEGSKPKRLRWVDIMAWLEFKASIKDLMGAFNRESKEYGLHTIDEETLESRDTTPDTTPLKPATTEPTLDAKVFSRVGSKRSRYSTESIDQTRGNDSGSSAKRKSLEYSLSDGRVDAKVQSGGYALETAACTYGTRYSCLGIIFDNDIMSPWYYDAAGYVSVNQSLSLLSDFPKVMAILVGFACLSHEKWGAIPPAISPPASAPYPTHFPPESLRDHSFDMMHPTSKRSVRVTLTKSLFTQYNLVGRRTFLYDIETNTVISKDPLVVKLSYQVVTRKAEHVVLAIAKKAKVEHLPEVHMWGDLWTMSDGIRQIFYDVSSEMSEDKEGPGVATYEDRTLRALVYTRYRPLKELFSKSCELVLVMVDQMLDCLHDLRYKAKILHRDISCNNIMYEIRDGREYFILIDYDLAIVVTDDGEPSAAASSKHRTGTLPFMAFELLQEMRDPGYGSKAPRIRHRLRHDLESMLYVSLWSSTSMPDTEDKKLRKEIVEYLTKWEKESIGSVADVKSALIMEPVMIDSVPFPPTSEFLRPAFSNWVTLLREARIQWSTHCRRIQSGRSTRSYDMETLNGMITRDTIKKAIKTGFIPGDSSDDEEVPAAVARPRYRLRNPKTSDNVEEDKTLFGGHSTMDRTRREKPKNIVASREKDMPAYVEADAESADERSVDKILNQTTAKKARGRTNKDVQPPLLKKVPRSPKVAAAKAASGKRTETTKKTTVIKKVKAAKKTEQVTPPNKSIATRAQRDRKNIGQASKSATSVTRTMTTRSMMKSANLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNF3</accession>
    <name>A0A2R6NNF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001047">
        <property type="protein sequence ID" value="PSR73939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNF3"/>
    <dbReference type="OrthoDB" id="3066072at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="29449" checksum="A86E0C3BB347196D" modified="2018-06-20" version="1">MEPPSKDQSELVVTAAPQYHIAVPPSLPPVASRQALQAQNAELRALVELAAAQIVRDHAQMVLMDLENGSLCQQAFAKEKKRQARFNTTHARHLTAEENIDALARAEWEGRMQVLFREEKETFDARCKALLRLDVLEKLRRKEELRRLQEKVREEKQLAVAQEKAAKADERVRKAEERVQKKTEETADKVKKAEERARKKAEAAAEKQQKAEEKELKKQKLVQKKQAAEEIKAATVAGCKMVQEVDTQLFLLQANATTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNX4</accession>
    <name>A0A2R6NNX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNX4"/>
    <dbReference type="STRING" id="98765.A0A2R6NNX4"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="138"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="417" mass="45200" checksum="770B86B618B43CAB" modified="2018-06-20" version="1">MPKPLETDNPTRSSLPPLPTQHSQPDIATSSSLLRAKTPTTLSVKRNSSIGPGVPSSPYRHNSLPAQAIKKRQAAIGAVSSHGRLFKVLGDLFLLAGRTMDASVWYSEAVAMLKATQDTVWHASALEDNEKEPWSEIADKLSQAISLYQKTPPPVDVETNHSFVAWFYVRAVLRHASLLFAIWSAKGWGPLAFTTMLQTGIASVPQTLTHGDPSRSNDGKRISSNFLERLALLTGITRSTISNTLAQAHGPWLLHLGARERILILEHMAAMYGMLGFERKETYILREVLGCVMDLVVCGREEGGGAKIGGAGLGIHGVDLGAGSNQGTVGIRTNNSTEGNDSVLRVVKHICKAHGIDLDAVKLVDNDSWRNSASQTATHDDELVSFEEPYGWPELQIGIVREAIAVAEALPGPFYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPA9</accession>
    <name>A0A2R6NPA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000996">
        <property type="protein sequence ID" value="PSR74321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPA9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="295" mass="33762" checksum="36F0546BF673490E" modified="2018-06-20" version="1">MPRLRSLVLEELSFENGRGRSNSQSVALAKLEKLAFKRFKQTLKVASGAFKEILALFSEIGELHLSKVPLRSSTLYLGPGVALRVRSIVMEYMDIPLHHLICHNQALRLHTDTFESLSVTCNTEPHIRDLGKVNQVFGAAIRHLEIDMSLRHVDRRWYIAPRWEEAHFECLTGLRSASLIMHEFWRHPLPGCLAVLRAFVTCKSPVQEVTLVFAVEEGPMASITDFPPLYWREAGVILKGLKHLEKVFVFWNDFHLPMNTTPSCSLTRLTFGADLRKYIRSKLPELQAKGMLWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPC8</accession>
    <name>A0A2R6NPC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000995">
        <property type="protein sequence ID" value="PSR74341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPC8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5864" checksum="E4BBF4597B498E42" modified="2018-06-20" version="1">MAARVVWTTTTTTTKDIDEWTIRNGMGAPGFILGIFEMDQVRPTDPEKGMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPQ3</accession>
    <name>A0A2R6NPQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chaps-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NPQ3"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="759" mass="84884" checksum="5D5AB420FC5CB5BD" modified="2018-06-20" version="1">MAEASFKDVPEIFEVDLGESLTARTESLSTFRELGPPDLCHVVKSTGRTGNRDLGSYHYVSGVDASSSASLAAYINSLTYAIEEDAGWFTKGAGWKVRNGSYCCFNAFSRVDVRVEVKIPGGVHAYVVDLRGERHDATAEIWQETYLSALLRSILYSDDPVYWLEAYRKVDPITTPEGELRFLQATEALFNKGWQVGSDPEIQVATVVSNHLTNAIMKYFGDSGRYQHAANLFEKLSAKEPEVSSLLARSYIGMSGYHSIRLCVLCIDQMFIDEEVKAVQIISAAMKQTPQSYTLLHAQCDFLRSKNNYEWALKLARQAVNCAPSEFVTWEKLTELYIDLGNYDSALLTLNSCPMFTYNGRDAHRNLPAARVHLPPKGQIVDILPDRAKTEDDEADPALLRLPAPGLRGTWARAYALLTRLVSKIGWDELLKTRSAVFVMEEEYRMQKAQTETQPAASPVIHEDGSVTLRSDDSTLAAKLADDDASTRGVRSTSGTPVHSPHTSSGANGEGDVDKDVDSITNGIPTIRISTESNRERLKQEAEANGVKENGEGFKEAAGLGLEKPVQAAAGEQAAEGNSDEQEAFSFSNKRLCERWLDNLFMVLYEDLRVWTIFRAEVAHFKTQHVAYRKTGMEWEILGDLGLRLQHKEEAKEAYQRCLDSPRYSAKPWIKLLDMYAEEGDIQRSLQVAIRVAAYQYGEYTEMTYPTQIAKCLFKLGQIHGHAKISYTLMSMSLPEPVLKIMESFLHYGNVFKVEGYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPU8</accession>
    <name>A0A2R6NPU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPU8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015309985" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="6855" checksum="19E07C0C8A137503" modified="2018-06-20" version="1">MLVSLAVVFAALLAKEVSAVAVGNNLPLRSLLHVRQDQVIDPNEIAPEAGLRMPPFKNKLNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ43</accession>
    <name>A0A2R6NQ43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ43"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ43"/>
    <dbReference type="OrthoDB" id="3169018at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="869"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1162" mass="130501" checksum="C43F306E30825C09" modified="2018-06-20" version="1">MDELGRLACRCVLDLYRSVDLTASQTSSSASDDSNAVEISSVGTLASEVTELPLIIIPCTHHSNIPIEYFTILLDLNDAINTMELSLLRIPLMDQESKILHFGVLSRLRHLRWTKRLHRSDLAAATSYLRSCTESQVIDSFHQGVFYEEMGVCLSSRYCLQKDQLVLESAIECLQKSIASVRRASPTKPLIFFIWQLAYLQFYRFEGTQDVEFLDESVRQLRQCIMLSVIDNAALAACFRLLIRELVLKFELYQNRADLDEAISIHDYLGALPKRALSPHDKDLAARGNRKIVNTDRWRTAHSSLLYLRFMDTGQYRDLQSAVENLEDVLQGLDDESAAVREEATASLVNCLMQRFRVHGRVEDLRRIEELVVYDSTPSVENIYNLGKLHIMAFSWFRYQGFIDEAVKYLLLSLADLAPRMHTSLKDGVPIETEEESTFAQAALKQLRDAGTIAHYARHSRRQGILPSESRFGHGSDWLQHTSRLHDLGRAITMQFEFSPLRDNRQMGIALTVLRLAEQLAPRNSFQRWEYLFSLGISHRVRHEVMQQETDIAEAIEMQSKAVEKLIFPNPRRIPALSCLAHSLMQSARASGDVAQYHQAVDHLERVVDAFYGFIHDRLEGAILWASLLHTNIPFPFEEEHAQLQKALEGYQKGILLLARAVWIGLSTSSRLARLHSVPKTFASDAAACAIRLAELQTDPGQRQEYLGKAVELLDEARAILWSQASQLHADLRLLSTQHSDLAAELNAVAHELARTAFKDGNADSGRTTEGLAYKWESLVERVRELDGFHDFLRSIPFAELRQAAGSTSIIIVNVSEHRCDALIIPPEGLVRLVPLPRLSKSQVEDDVQDIHNMLPSYEDRGEFETVLNDLWLDVCKPILAELRDMGVVGQRPHAAGTRTPHIRWCLTGRLAFLPIHAAGPRYQSRRKPGMLDWMTSSYISTLSMLLRAQHRTETSQGGVPSPRVLAVCHSGGGGRGHLPKAKEEVEILRSCAQPETVSVILDQAARVDVVSGALRGSNWVHFACHGTQNHANPMDSALLLDDGKLPVSTLAEQNLKGEFAMLLACETAMGMPGLSDEAIHVAAALHFAGFKSVIATMWSICDDHGPIVAEKVYKHLFRKKADGLLPDALEAAYALRKAILYLRDKEKLSVRDWAPFMHFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ59</accession>
    <name>A0A2R6NQ59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000964">
        <property type="protein sequence ID" value="PSR74695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ59"/>
    <dbReference type="OrthoDB" id="2692137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="574" mass="65509" checksum="63CB03146D9B4C1B" modified="2018-06-20" version="1">MPMWLNLSPVNFVPLNSCMIRSLGTIDYRTTDMLRPLVHTMQVRMAALEEQCGRQPELYHIVIAMQEAFDRLDYPSTFRDLLFQFSCVQRYWLLASAWFEWHIHIWRSFPFVEQRAAPPSIRTDLMGAMTTNPSVVQQLSSVGIPVWFMRLMDTVTNEDVVIESVSFIEPVEIAQESGLFGGSPIYTGPVGERHLQAIARRCNFYADVERVPMPRVLQSLSSAVPSDMASTSSAASHAIAPASLVVRSTPGRSCVRHTPYPPRHKAPKANPGERCKFHDFNSVYMPPCIPVWRDALARVNRAAPAPEGADVWPYWFPEPALVASPTKDDRLLRHFVNWHRARSPWIYVVTHHSMTDDVIRPLTPAQWREYLNTGDKSREDAKTKNTKKSEQKRQIAAIFSRIFGEGNVVEGQVPGDWFGRAVNLIECKDSLIMAEMLWELSEMGFRHELRELDRYLVPFVAKQPDVGESQRRLMVNNVFPPSRPFHMKELPTKVDGLAASNLADRVRYLDALRQIVCRWPNVPPSIQSSPSLLDLSSAPFLEKIEREMAQFYCQTFYEVSGRAAVLPRKFPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQM8</accession>
    <name>A0A2R6NQM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQM8"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41732" checksum="ACA92AC3ABBC5598" modified="2018-06-20" version="1">MDDSELQVQYNSKQLVAGDVVEGAVLMNIPLLETKHYEEVHTIFAGIIKAQITNSSCEVDLFRQFETVWKPAIPSSAGSANLHVVKVPFRFTLPSVLPASGVYGKNPFTATVHYFVKVVGIRSGFHKNKEILCRFAVVPSNIAGFELSQSFKAGWTGKWKTVVEQKRMRQFFFGEYASASVILTLPDIDTFPIATSIPFTLELTTLTKPAIWKEEYQWRVGDVLFPTPPFDPRTGIAFEIAQTIFLDTGQERRYSTGHEIWRLGGFGSEAGEHAKAKISEPLWVPIDGDAQGRGMYKQKVVFTSNFVLKCSPCYESNLLKVEYMMHLKVDFPGTRNEVKLSFPVRVVSNRRPPTASSRRPELHPPEDAEAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQT2</accession>
    <name>A0A2R6NQT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000945">
        <property type="protein sequence ID" value="PSR74889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQT2"/>
    <dbReference type="OrthoDB" id="5419324at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098636">
        <property type="term" value="C:protein complex involved in cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046871">
        <property type="term" value="F:N-acetylgalactosamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23422">
        <property type="entry name" value="beta-trefoil_Ricin_MPL_CNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052487">
        <property type="entry name" value="Galactose-binding_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46938:SF1">
        <property type="entry name" value="DISCOIDIN-1 SUBUNIT A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46938">
        <property type="entry name" value="DISCOIDIN-1 SUBUNIT A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="H-type lectin" evidence="2">
        <location>
            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="H-type lectin" evidence="2">
        <location>
            <begin position="350"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="H-type lectin" evidence="2">
        <location>
            <begin position="444"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56710" checksum="DAF5C387698CAD23" modified="2018-06-20" version="1">MKHPGQPSVAPPAHSLSKISKSESNPTATALADSPKKRSTLKPGVYTLVNAQSGTVIDLSVMDHKTVVGFPRHNGDNQQWRLSLLGPGYTIQSISSGEYLTLKEGITHGAALSMSSFPVIWKVDAYEEEDELFVQIFWPSETLSYVLELAGGDTALFTKIQLASYQHDQRHQLWRVAEVDRWEERSQLKSGAYTPVSAQSDTVLPESSIFERSSIDTADNEFPPPTAARTPCPGAIHSGTFHIESIRPVNQPRQDNRGTIYFTPPISTAYNLLLGINALDIGCSADFTLKCNLLSVANNSVQLNLQSWGNTVQYSSGCAWLRVPTDDLDFQSGRFSATDYYPWYKPHVSYRIAFARSYAAPPKVVVWLDSIHTDANTDCRIHVYANDITADGFTIHLDTWNDTKLYLAGATWAAYSADRVGIRSGSFCAGDARNPTKLPSENSAQIAFDGADFRNTPRVFMALNLLYVDCKHNTRLKPICATNVTNAEMTWHIDTYLDTILYAAGASFVACDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR31</accession>
    <name>A0A2R6NR31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR31"/>
    <dbReference type="OrthoDB" id="2802108at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10638" checksum="F46ABC2B15F90A52" modified="2018-06-20" version="1">MAANSSTDVRTPLLKNSSDDELFEVADLEDVGVVLGSRARQELERGLLRKLDKRMSILVVIYILNFVGLKALPDYPSYISFIHCIRLTVITLGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR40</accession>
    <name>A0A2R6NR40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000929">
        <property type="protein sequence ID" value="PSR75104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR40"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="6355" checksum="C0973566A196594D" modified="2018-06-20" version="1" fragment="single">KFIDTKDSDLNEEEEEEEEEEERRGGSRRVVRVHMFPITLALHTQLIILIKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS08</accession>
    <name>A0A2R6NS08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS08"/>
    <dbReference type="STRING" id="98765.A0A2R6NS08"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="236" mass="26766" checksum="022C73DB812EAD6F" modified="2018-06-20" version="1">MKAIKYIHDCGIVHRDLKPENLIFKTKAEDAEIMITDFGVSRVMEDDKMQLLTEICGTAGYMAPEIFKKSGHGKPVDVWAMGVITYFLLCGSTPFDRDTQKQEIEAIIVGDYKFEPEEYWVNVSEAAKDFIRECLTIDPTSRPTAEEALKHKWLADTESHFVLDQQGNMKNLLPHIQKAFDAKKTFRNAVFSVMATKLERMSALASAKQLSPETSAFGADIVQYMEESEKEIIDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSL9</accession>
    <name>A0A2R6NSL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSL9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="9001" checksum="EFAE7C20496021B2" modified="2018-06-20" version="1">MHTSCSWNACIHLNKLPNRLSGANRLPIVGCGACQITTYTYTDHANFSYMSRCQSKYAPTRLKSPKVIIKRALKATLAAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT96</accession>
    <name>A0A2R6NT96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000858">
        <property type="protein sequence ID" value="PSR76222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT96"/>
    <dbReference type="OrthoDB" id="3265564at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="206" mass="20765" checksum="40325D5A4EAA3000" modified="2018-06-20" version="1">MLSFKSFAVLSALAFGAATTVFAAPLTEGTNILARCGCSSVATIIDDLTVVVTPITQEFHYITASNCTVSALTPLVGQLKGALSDAVGEVNKLVGQPAEIILATVDGAAQITVIELAQLISTLVILIFTALGAVLNVASSTVVGCLTPLLCTVGEIVGALLSAIFSVTGGLLVGLSATVLGLLAEVIAIIVRLNVSMVISVVGIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTJ9</accession>
    <name>A0A2R6NTJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000847">
        <property type="protein sequence ID" value="PSR76399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTJ9"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="53"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121114" checksum="90C28BBEDC7DFF37" modified="2018-06-20" version="1">MPNRSAAAAQGVLGGHGTPGPGMYPFTPYFVTKSTFLPVDTVQDTRREQIQEWTWLAQALRTGDDGKVKDCDDDIDTLLVFAGLFSAVLTAFNIESYKNLQPDSNNISASILQKISRQLGSFQLSHGFANSTEPSSASPGFHVEASAIRINILWFLSLVFSLITASLAILVKQWLREYRSGKQTAPDEYIRVRQYRYEGVIKWHVFEIAAFLPFLLHIALFLFLIGLSDFLISLNPIVGWFVTSVVIVWLLLYAGSIVAPIFFDGCPYTAPLVKVGTRAARRILWHLRSKSPLGKQTRLSKYYDFPGDEKGLRRDKRLDLPAFVTADEILSDDSFAEYVLRPCLRGTGGPDTTIFVQAMLQHRLGHPIPTLEACTTGHLDFSRLNTRSLVVSILILLDALDSAITAARENAIWSPWMHEALTYLCAAVNHCGPFRIRDIGAVKDAVLDMGGSLVHLNIDFIKEFFLLSSKFPLICFPAVPMISPERTLLDVVMAAATLCADGEDPLQLCRIVLHVISQQLIMILRGELPYNGTGFGGRDLQDPTMSFLRFHAVANTIRDSATWEGLMHTLATAIRQQYSTGSLLQDAEAVYSLNKCIENCQDLNERSTNFIPPSLANVLLGFRTNLAEYKLGNMVPTEIHAAPISAPQPDRDISLPGEAELAQGISQDGSRPISRNPVQLGAGVRFSTASWPLPVFDLGLPPDCFPFTPVESPRPIPKLTDLVPIFPTDGPRFSPTSPIDPFSIPVSSLPPGFIPTHYLSFNMTTETPDDRVRQELHSQMKDPDTVNTAKVDSSSIFRPLLSSKMDAATVIPEKSLPIRVSSSALPVPDAFCIPPPPPNHPFVPFEPIRILNINIAPLNTPLMPQALVSNAVRDPDWSRFITDLMLAGSGRLDASALSITEAWNISFFTARRINVSLVLSAETELEDDRQSDPHIAAGLREESGDSLNNRAIQHDEFEPAQALCLTADPTNTHIPKVHIHPSYELWITYIKKPPPRRALSYSTLYGTPNYDLRGFDIGLKSAGINSARRRPRLGRKSVHWDPGFVSLPIVRLGLFHSYLSHRHLRQHPRSISIGQYKPLSSIPEADEPFRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTS6</accession>
    <name>A0A2R6NTS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHLCEN_2v8431</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTS6"/>
    <dbReference type="STRING" id="98765.A0A2R6NTS6"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="24"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PSR76528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="357" mass="38107" checksum="87FD2D9DC4256F1F" modified="2018-06-20" version="1">MFAAALRTKVVSRAFTSRAVDGFTGAVGNTPLIHLKKWSEKTGCNIVGKAEFQNPGGSVKDRAALGVVRDAEERGLLRPGGTVVEGTAGNTGIGLAHVCRAKGYRCVIFMPNTQSQEKIDLLRMLGAEVFPVPAVAYENPANYNHQARDFATKLPNAVWTDQFDNTANAKAHYLSTGPEIWEQTNGELDAFICATGTGGTLAGTGKYLKEKSKGKTQVWLADPPGSVLHSYIESGGKLKDRSGGSITEGIGQGRITNNLGTFVKELDGSLTIPDEKSVAMVYDLLDTEGIYIGASSALNVVAAVELAKLLGPGKTIATILCDGAYRYQSRLFSKAWLKAKGLEDAIPEHLKKYAVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU68</accession>
    <name>A0A2R6NU68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU68"/>
    <dbReference type="STRING" id="98765.A0A2R6NU68"/>
    <dbReference type="OrthoDB" id="2801555at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="198"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="268" mass="28025" checksum="8FAC0293645578FE" modified="2018-06-20" version="1">MAEIYAPEVALNSIPDDLTVPQFFLDSSHPLKPANNTVKPWMIDDATGRQVGFEEIGPSCYANPAYTADELLHQITLTQSSLLVTHSSSLSVALSAAKTAGISPDRVIIIDSLEQAGSSVHVTVDELVAAGLAKQPMFVEKRLKPGEAKRKVALLCFSSGTTGKPKAVEVPHYAMVANVIQVALAIGSAPRYVPGDVALGGLTETFTAVALSSNDQKIATPASAGVLIPGIVARVVKPDGTLAKLGEPGELLVRGPSMALGYYKNPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUI2</accession>
    <name>A0A2R6NUI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000825">
        <property type="protein sequence ID" value="PSR76915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUI2"/>
    <dbReference type="OrthoDB" id="2793557at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098636">
        <property type="term" value="C:protein complex involved in cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046871">
        <property type="term" value="F:N-acetylgalactosamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052487">
        <property type="entry name" value="Galactose-binding_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46938:SF1">
        <property type="entry name" value="DISCOIDIN-1 SUBUNIT A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46938">
        <property type="entry name" value="DISCOIDIN-1 SUBUNIT A-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="294" mass="32874" checksum="DECD7039FC57CC2E" modified="2018-06-20" version="1">MRPTTNIYPARTYHKLSLDTGSFNTASFRPWHNPAQDNFGIIHFRAPSTSYDILLGINALDMADSTDLSLKCSLLSFADNSARLNLQSWGNTIQYSSGCSWLSVPADDPDFQSGRYYTIDHQQWSKPQVSTRIVFKRSYPSPPKVVVWLDTIHTDANTNCRAHVYPSDVATDGFTLHLDTWHDTKLHLAGATWVAHSSDRTDIHSGSFCTEDVKTTAHPQLENSARIAFNGANFSSSPRIFMALNKLDIGRQRNLRVSPVHASDVTNTGMTWHLNSWAETELFSAGASFVAYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUR9</accession>
    <name>A0A2R6NUR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v8056</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000813">
        <property type="protein sequence ID" value="PSR77111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUR9"/>
    <dbReference type="STRING" id="98765.A0A2R6NUR9"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="350"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="672"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="694"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="442"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR77111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="709" mass="78382" checksum="9FA7C97FF8DD52DB" modified="2018-06-20" version="1">MGRRAKNKQGDPTPLKDAQAHDSTGRPSAKKLGKRKAEVQDDERETLSKRPMKKMKESEGKQAPKKNQVKDDKKRTKKFAISSVKTKTKEPEDEGEAGGSSEGWEDVEGEDLTSHKKSLFHDSDEEFAGFDGDLNEYDIEGAEDEDDDMLRGPIQELDLGSEDEDDEEELPAVKTKGQKSKQHERPSKIIPTGSDASSDEEDEDEEAPVTMANMEARSRALDAAAVRDADLDAEEMRQAELAGEEEDDFADADMDADEEGEGDEGAFQLPTAEEREQEKKTGGPQVQVVQRRMRECVRILNNFRRLGAKGRSRSEYVSQLISDIASYYGYNDFLAEKLFQLFPVSEAIEFFEANEVARPVTIRTNTLRTRRRDLAQALINRGVNLEPIGKWTNVGLQVFESSVPIGATPEYLAGHYMLQAASSFLPVIALGPQPGERVLDMASAPGGKTTHMAALMQNTGMVFANDANKARTKSLTANVHRLGCKNVVVCSYDGREFPKVMGGFDRVLLDAPCSGTGVISKDASVKTNKSDRDFTLLSHLQKQLILCAIDSVQPESKTGGYLVYSTCSVTVDENEAVVDYALRKRPNVKLVETGLEFGVPGFKSYRGRNFDPRVSMTRRFYPHVHNMDGFYVAKFKVEKRAKKTKEEGDAMDVDAGVEGVAGKFAFNDDEDRPYIEESKRKSLKAKGLRVPPRTKASTTTSPAKAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV27</accession>
    <name>A0A2R6NV27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v7941</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV27"/>
    <dbReference type="STRING" id="98765.A0A2R6NV27"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR77340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="564" mass="60865" checksum="68DA9D260D30A070" modified="2018-06-20" version="1">MVLADLGRKLNAALSSLNRAPVVDDKVLDILLKEVCAALLESDVNVKLVASLRQKVKAKVKASLESGADKGKDANRKNIVQKAIFDELVQLVDPGVEPYKPKKGQSNVIMAVGLQGNGKTTTCTKLAVYYQRRGFKSCIVCADTFRAGAFDQTRQSATKAKVAYFGSYTETDPVSIAAQGVSKFKKERFDVIIVDTSGRHKQESELFEEMVQIGEAVKPNMTVMILDASIGQAAEAQSRAFKDSADFGAIIVTKMDGHAKGGGAISAVAVTKTPIIFLGVGEHLHDLEKFSPQPFISKLLGLGDVQGLMEHMQDIATQNPDKQKEMAKKLEEGKLSIRDWREQIQNVMNMGPISKIASMIPGLPQELLQGSDEEGSQRMKRMIYITDSMTASELDSDGSPFMETGKDGKPIGLTWRVTRVARGSGTSVREVEELLCQYRMMANMAKQAGGKNGWLQAAQKMQQATGGRGRGANGMPTPAQIQAMQRSMPPGMLQQLQKTMRGGGGMQEMMKAMMQGQGGDQADMEEMQRMMAQMGGGLGGLGGLGGGMPNMGDMFKMMGMGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV65</accession>
    <name>A0A2R6NV65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV65"/>
    <dbReference type="STRING" id="98765.A0A2R6NV65"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="323" mass="36362" checksum="ED38472B2AD5636D" modified="2018-06-20" version="1">MSVEPDIKIASTPFDDETADLILRTIDNVDFYVHKFILSKASPVFAEMLAFPHPPPGAQGVDAGDYCNSIPVVKIQERSNEMDNLLRCWYPNCVPTLDEISAIVPLRWDCADALGRFAETDPLRVYAIACRFGFETQARQAAKCSLLFSFFSLSLTSGAIGEELELITGAELQRFWRYRSDCLSAVSCLTQASYWTDSWKRECLPLWRSSIAADCQCGTNDRRFEGVMTRYDPEQDGNIEEPTMYYVTNWFVRYLQDIQDGLDGFYKVLSRDLTRACTDAANRAATTANACPVCRDEFFSGFSHFFASFTAEAGVEIAMVRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV71</accession>
    <name>A0A2R6NV71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NV71"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="94"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="956"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1280"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1449"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR77423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1702" mass="185758" checksum="79E7A3D0ACBE934E" modified="2018-06-20" version="1">MSDSINQGVDIQLRILQTLLSLITNFPAVHGELLGEVQSRIAVVSSTAAATLRQLVMFVVDKVVDEDKRDDLPRSDFSKTTLPNGSTKALGPSAKDAFSVFEDLCLLANSEKPTFLKLETLRKTFALELIESVLTNYHELFRKHEELLLLLQHHLCPLLLKALSDRPSFPLTLRSTRVVFLLLKQFSSELNTEAEVFLMLLIKIVGADMEAATPAQSSESFHLGHGARPQWMRVLAMEIMRGLCSDAELMRNVWARYDAEESGSKVFTSLITALKRLITEKPAVLGVSSQMLGVGVPSHSSSSDGAAGYGLDVGGVAGMVANAASATMSNVVGMMGPEAGLSLQGSVMKLQCIDQLDKADSPPIPEPYVYLLGVQCLVSLCEGFAAFVGPLFNSLVVQRPRNAGEPVVRAPPALDLSSLPPDDPATKQLQLVHDMVENGWPALLAALSFVVSTNLSDDLFVDVLASYQAMTNVSGMLGLVTPRDAFFTSLAKFAIPSRVVSSLDTYVEPPTPRTPGILSDNLGLTSPAQAPTLSERNMACLKVFVASSLFLAGSLGESWFNILEALQNADYVLTTKGAKAQGKRNTIGPGTGVTAINRSVSAGNVPVGGQPGNSSPQQQSARHPLLIDLDVDSLQHSIQRLFDASKNMDDRAFHDFIASLCKLSAVMVGMQSEDSDSAIELKLVDELPTSPSLSLPVDPAHRRRVSGIHLARTLRSGDFGITKLGGVAKLNIHRLIYRDPEVAWDIITTHLLSVIKHTLAPTTIRIQAGRILDDILTVVPRNLSTTGELQPKVQRRVLDVLAQQVILDTYAGNNATTVELRRMGLETLHQILQASGHTIVVGWETIFEMLGSVCKPASSLIDPSSSPSDLGVASRKPPPLGYVTEKSYTSLVKIAFQSLTLVCDSLSQLSPEHLRLCITTLGQFGRQADTNIALTAAESLLWGVSDSIQAKRKDAEKEPEFSSLWMFLLLEILGLCTDGRPEVRMGAIQTLFRTLQLYGATLSSDTWEECIWKVTFPLLDSISSSLRHSSSPSAEGAESAVDPQWDESKILALQSIGSIFNDFLTSKIMHLESFQQAWEIFVGHISSSWLNDVRNISPPALRCLDKAVNALATTDPALIDKTLDALEVVWQACDIMGQAVLDSRTVSMSYRPFTQESLVTLVDVIRSIRSVGRSLRNVEWPLERLTRLMAILKGVLTYSDSPDFRPDVDALSPVQSVVVEAIDSIDLSTTGAPSLVLRDLSEHATLPFLAGFDVPNSLTHGGIPKDSHAPKQDRGSQKRVTYIGLSKKTMPQLVDLFLRFKDQATVYNDGTVEAIFSAYSIPIKLKYECPAPSKFGKDLPLWKTATTSFLRIVKECGTQIQQLGDQILESRVESIWRQIVDTFRGGILADCSAAEAFPLDIQETEESFDLALVASLEIDVVPHLGDSRVPDYIIAQLARVLQQGSRIRETDDYRPPSPISPGNKLPEPSFEFDKFGALGEYGSNEVGRFQPRERFSYWCFDLLVLICSDTTKDQVTSRRRVATVALPSLLNRCKSTLVSFVADESLRGNLPFSRAREEELLYVLRKMLGLRLWPGTLWAALSDSPSEYSSEQPSIDTTLKASELIADAVKRSTKAHLFHFYPVLCEIVAIPRKTPTAWSAVSALQRPNGPSRSMSVSEVKGAVSWSSVTSGGQDEGKAVELDARSLVKECLKEIGQEMGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWF1</accession>
    <name>A0A2R6NWF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Guanine nucleotide exchange factor Vps9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWF1"/>
    <dbReference type="STRING" id="98765.A0A2R6NWF1"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="333"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="707"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="82775" checksum="FB4CD18CC5F7FEE6" modified="2018-06-20" version="1">MTERDDAQLLEAEDSLATLHISKPTTTDEPPEPNPWQDSTHNILEVSVLANNTLEGMAKSSDVSALDPSTAKGLAAEVVAVPDEEEESRQEILQEFDPLANHEEKAAKAAWESSDSNPPSIAPVAHPVADAPPPPAPTTHAIDLSHPSSPSLPSFPSLAALARTFALPLTSRQRPRSLDTATAVPSPATLSSFASQQQQPRTILPASDSGRSTPTRIGKANDGDPLQFDFQKFLDQMKLKSAEPVAKYLRSFLSNFAKRTFTVNDQVKLINDFLVFISAKMHETDLWRSASDAEFENAMEGMEKLVMNRLYDFTFTPQVIRMIPPRPVTTDDLERDRVLSQRIALFRWIEAKHLDIPEEHGSEGFLMFAQQELLKINHYKAPRDKLICILNCCKVIFGLIRHLRKEEGADSFIPLLIYVVLKANPEHLLSNVEFINRFRNPAKLQSEAGYYLSSLMGAVSFIETMDHTSLSSITQEEFEKNVEDAIQSLPSTGAHTPEPGTPVLEHVSNGQSTSIPLPSSHTGEESAQPLALPVPTQTISEDARRLLQKTGDTISKPLSAIGRIFNEVLDGAEESLASFTPFELGKDQPDTPQTVGDAVSSSSQQRTPYKPRIRRQPSPNSATSSEWHLPIPEDTPTRPHIGLPHTNQPLSMGPSQPTARLQAPRVQSLLLSERDLYSQSPHVSRTPTPNLDFVGMQQEIDRVHESAASASRETLRQIFPTMDPEIMDLVLEANGGDLGKSIEALLEMSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWP2</accession>
    <name>A0A2R6NWP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWP2"/>
    <dbReference type="STRING" id="98765.A0A2R6NWP2"/>
    <dbReference type="OrthoDB" id="3254377at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="492" mass="52628" checksum="86A5040D44F2DFB4" modified="2018-06-20" version="1">MSTQSTLNSVLAGGSEADISLEVHARTLSSRITDKSTWMEDLDQISKGVEGLFSVEEGGSSGDGQVEEAVSQSLPASSSLSTVADRITRNHLRRPSLDINDATLHFSNHDRSDLVAPPPRALTMYVDSLDDPDTIPIPSTLGIRSSSRLPTTPLPSETSIMSRRPLLLQGTVSESEVPKRALDVLSSYATMRERSTTGSSSNSNSRTASPSSSYRTRPRSGSASTSTTTTVTTRKTRSPLVERSRSPSHSPSRSVRRTWDTPPIIELPSASDSSSSEDMHVDRTLTSLRTILQNNPPPQPKEVPKPSFLKPPTVVPIADTSHATASVSRLFTKPRHSSSTRAPSPPRVSAMKGKSGRSAPPTPISPSLSLSSSWISVSDAMGIGSRVGSGRNTPNRVSFAELPDNGRDKDSPSSSRIRSRSRSRSRKGKGKARGDESGSEDGSGKWWTWLLGPAPASGPAAPTYVRQEERVARGSAWGPRPGFAGSIEEWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXC7</accession>
    <name>A0A2R6NXC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipase C/P1 nuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXC7"/>
    <dbReference type="STRING" id="98765.A0A2R6NXC7"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF29">
        <property type="entry name" value="S1_P1 NUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR78587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44436" checksum="A56E6EEC3F479D65" modified="2018-06-20" version="1">MKFNRACTYAVTTTFILASVPAAYAWGAAGHQIVATIAQIYLHPTTLSNVCEILYPGSSTSRQSPPCNLATIASWADQIKRQPKYRYTAPLHYIGALGDHPSEACAFPGPRGWAGKKDANVLGAVRNVTNILVEYTNGLYDAEAAADALKFLVHYLGDMHMPLHLTGRDRGGNGDRVTFDGRVTNLHSLWDSLLIAQRLRTIPTNYTRLFPPGTTSIDVESHLRGAIYDPYVRRVMFEGMGVGSVSGRYEKDYLNWLSCPAVETQSVWNTLQTVFGLHQLGDESRWDDDMLCPFAWAKQLHPLNCDLVWPPELDEPPYKNTGEVARSSVEETAVTSRPNPHPDLLELDTPEYAGRIRDEWVVERLMAMAGVRLAGLLNGLFMNPEAFKEGLINGLRKKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYD9</accession>
    <name>A0A2R6NYD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000669">
        <property type="protein sequence ID" value="PSR80107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYD9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="112" mass="12796" checksum="C10C795AD7FDE8ED" modified="2018-06-20" version="1">MCDNHNRKKMMTDRQKRKAKNGQSRKHAQREEIRHMIRGRMENGELSMELELEDRSARGMKRATDDSIARSSEAATETKGTKERVAVNQDGFFGEDIGEDELEAGDQDMHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYJ1</accession>
    <name>A0A2R6NYJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NYJ1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="47"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR80361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="382" mass="43007" checksum="BC339359BF65D2A1" modified="2018-06-20" version="1">MSKILKKWVGAEELAKSAVLNVATPWYDLNTGERMGCAQWRPAVMKETGGDFLLMKHEDVHRMVYRLAVDAGAQVDFGVTVESVTAGNPQPQVRLSSGEVLKADLIIGADGPRSKIRRYVHKKEDDALPSGFTIFGTTIPATEMMKDPELAKLVQANERAKAEFAVQMYWPDEDAGTPKDATESWYDIVPTSSVRFDNLGDNVQRMMKLTPYLYRTRWMTRATEIDEWTDESGRIVLMGEAAHPWFPGGTYGPAMALEDAVVFGTLFQHLSSWEQVPVFLNAYREIRFDRTTAVNDMDVSNAAFVRLPPGPEKDARNADIRLARDEWDDGSLKEQFEGLANLFCYEAEDAAQEWWVTWGRYGQAARDSVQFGYHTLATNVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYS2</accession>
    <name>A0A2R6NYS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYS2"/>
    <dbReference type="STRING" id="98765.A0A2R6NYS2"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="15293" checksum="19EF41009349859F" modified="2018-06-20" version="1">MEDDLFTWDAGIAKLALNNVRKTGDVFGGSDDAFVREISFIDPATQTATITSVNLSLSQVATCYENILYRPAPNGHTTFIQTAEIQTRITIWRSMADKLENWLVQRFEQNAQLGKAGFSDVLRNLWEAKQQQLAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYV4</accession>
    <name>A0A2R6NYV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v6664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYV4"/>
    <dbReference type="STRING" id="98765.A0A2R6NYV4"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR80748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17691" checksum="93F1427DE92F0A09" modified="2018-06-20" version="1">MSKFPHLQKLLKYNSRRVLRLWSDYRVVNSASLHGTPWLEYTWVGVAYMLTQTAFQPLYGKLSDLVGRKSMLWLIISRALAGIGGGGIVSLVWTITSEIVQVQSRAKWSQALSITWSCSAVAGPLLGGVFSGKVSFIPAFKRFPDDPARANGCLKLEMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ57</accession>
    <name>A0A2R6NZ57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v6540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000627">
        <property type="protein sequence ID" value="PSR81063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ57"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR81063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="209" mass="22343" checksum="D4ACCAE055D43B36" modified="2018-06-20" version="1">MASDLGATPVIAEFSRGTTFARQIFFVRYIQWFITFPLLILLLLFSTGLTISDILTTGFFAWVVVVCGLCGALTPSTYKWGFFVLGVAALAYIWAVLLGHGPRSTFNAGGGVRSGYIRGAGFVALLTMIYPIAWGCCEGGNVVSPTGEMIWYGILDLLLGPVFLFYFVWGLRGVDYGLFGLNSGKYTDGPYGSAGGAPGARGPNMAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZH5</accession>
    <name>A0A2R6NZH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v6399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NZH5"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015321638" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR81320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="188" mass="19342" checksum="F4F34AA2A26CE76E" modified="2018-06-20" version="1">MFASSVLVALVALPFVAQSVAADCTRTYTITDGDICDSISAAHNVSTYQLAVVNPKIDAQCNNLQPGDTLCLGLTGQDCTTTYVVSQEDTCDLITSKHSINSTMLWANNPQINADCSNLYVGEVLCAGSVFAAPPPPASMPAATIPATAIPAGPTSVLSSTPAITSAAPTPSPSADDDDDDIPFCDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZP9</accession>
    <name>A0A2R6NZP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v6347</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZP9"/>
    <dbReference type="STRING" id="98765.A0A2R6NZP9"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="60"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR81581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="631" mass="68711" checksum="4C8B853157C68259" modified="2018-06-20" version="1">MLIDIFKKEGISGYYKGFGATMLNTFSMQYAYFFFYSFVRTSYIKRLSARIPKGSKAPPLSTAAELLLGAIAGALAQIFTIPVSVIATRQQIGRSLDSPRKKAETAEQIATGDIEKAAVNVGNLASSDASIPDKQEEVEAYDDSFIGIAKEIIEEEGVTGLWLGIKPGLVLTVNPAITYGLYERVKSVMLVAQQTASGNSDAKLSSLATFTVGALSKTLATVVTYPYIMAKVRIQARSADVDDAIVHHSSKPQPHHFHHDKTRHIGALDILARVWRKEGPLGWYQGMGAQITKAVLSQALLFLSKEQFEQWALAIIRIAHEKVEEQRGQLQEQEKQVALLRARIALLEGTNDPKIAKPGVSADSVDDFSIRLERLINGWAASVVNHPPADLTEIRQAALLDVYDGYPPEPSPYPAQATAIQTMSLLRHGMSKTISEGTINCLIVTDSPEANIQLTRIHEHIFSRDATVAAVWRRQTFSAAVESCSADMSRFFLSEGMPALTNILGPEDKEGSLISTAFPILQAGYEFSRMLHGSPSSSGGTIDAFYRAFVPELGNMLHPQQVELVKRCQKTERGEPDRVGATVFPGLVKVTRGVPSHNGEASPHVQTVVRRAQVICECALGLCTPGPQNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0N3</accession>
    <name>A0A2R6P0N3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v6232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0N3"/>
    <dbReference type="STRING" id="98765.A0A2R6P0N3"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="8">
        <location>
            <begin position="328"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR81860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="510" mass="57263" checksum="0B91C688719EAA45" modified="2018-06-20" version="1">MHIASSFFGIFQPELYSGDITVNTQVIQQPQQPLGLPKSDVPHPVVLNTPKPPPITDLSVDFPETTIDAHAPGWTLFHNLYMSNGTLYVVSSHPYSDFPDINLMTSTGLAAENTPENIAARMPTSQELDFITPEEARTRWGPIPSQPRSKNRVWNVQGNTLLSNDPSQFLDHYYHFCAELMLGAWAFWQGAHGAKVDPKRAELTTAPPFTRAIFAHADADGWRDRPGFNSYFLRASFPSLTVEVQADWQDRVAATSAVGDYARTWHFDSVLLSDRSAAFRGVICGTQVHRTAGEAFHFMRNNGNLTRWWWEPVRRAVLRFASVDQRVLEVGVRAQIESEKAKIDGLAGSRSQRQDVVVTYIDRQGVRRHLIDEDHERLVAALHQMCAIKGWELNIVQAEKLTKEQQLNLAARTTVLLGVHGNGLTHLIMMSPTPISTVIEMFFPGGFAHDYEWTARALGHKHFAVWNDTYHTYPNLPHVDYPEGFQGTEIPVHAENVINIIESRVAGSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0V1</accession>
    <name>A0A2R6P0V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0V1"/>
    <dbReference type="OrthoDB" id="2769307at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015351372" evidence="1">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="146" mass="15440" checksum="2828F8234F1805F8" modified="2018-06-20" version="1">MFFSFAKPTSLLALIFATLPALANPVQIQRRVTVFETSIAAPTTGTTISPGDSFPFSYTPADSCHEAYSGYTVWLLATSPTAADLNSTMAFSQYLYYFGGFTVADFPGLPAFSNAPPSTLSAPDLGESAPSEVFLTIVETISGCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P160</accession>
    <name>A0A2R6P160_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P160"/>
    <dbReference type="STRING" id="98765.A0A2R6P160"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="12"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR83082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="341" mass="35955" checksum="C6D73A687EEF6262" modified="2018-06-20" version="1">MDRHSPDYYVEPSPEASMTATRSLISHIRSFTSQPSTALVQPILTPRFAISCTPILLASLGALAKSDPNLAIQTHISENEAEVVFTKSLFPPEILPKPALGHVRGGTAGKPKKTTYAGVYDAYGLLRENTVLAHAVHLEDEEAEIIKARNAGISHCPTSNFNLRSGCAKVGMLLDKGIKVGLGTDVSGGFSPSILTAVQHASIASKVVAMHHPPCDPPSPTGFASRQLPVSTLLYLATQGGADVCNLSSWIGSLSPGKAFDALVVSVRSDAGNPSVWGADLDIELGVRGSGGEGGDEGGRGRTEKEELEGMLERFLFCGDDRNIRSVYVQGVLIGGKELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1B9</accession>
    <name>A0A2R6P1B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v376</name>
        <name evidence="2" type="ORF">PHLCEN_2v5822</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000031">
        <property type="protein sequence ID" value="PSS37775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1B9"/>
    <dbReference type="STRING" id="98765.A0A2R6P1B9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="143" mass="16853" checksum="4FB2259860DE680B" modified="2018-06-20" version="1">MSLHETSHYWMDPNDTISDKEWGTTLLYTPGYGRVRLGPEHRVFVVSYFHQLHCLRGIQGGIVFPGRDEEVRGTYEHVQHCLNYLRQTFLCTAADMLEKGDFMENSFEPGTLGDDLVCQDWEVLLRAMRDNYDEFVEWNQKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1C7</accession>
    <name>A0A2R6P1C7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000563">
        <property type="protein sequence ID" value="PSR83273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1C7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1C7"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="494"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR83273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="562" mass="61799" checksum="220F6D0448599415" modified="2018-06-20" version="1">MTHGKGREFKKLPPVKLETLLLLEAERAWVYSRELSQLATLPANKDKAAALRRNATSRFRRAVNWATQMLSHCQGLHATGRLSASDLIQATVYTLVLNGRFLRHRYDFGDALVQLSVARSLLDELAAHASTSRDQALATAFADEIGPEIRHCSHEMGNTKAYDVDSIVLDSAATQKNQLVEGYDKLVQELSKESAGGASAERKKLKPLVWEEEPVPVRNPELVDVLLKVQQAEEKLKEMPSDKSVATGEDDKRKGKVGKGTKSKRGVAAYDAILLALSDAEGVARKLVEAQQLSGSTTVTPTGTRDVQFVHAYIVYQLLARRIQRDLLLTSTILHQSQHTSHRNTSKAGPSKPSGNKEHVDARLFPAVVKLLDTIIQSLTQMRTLTVVDDSPDLATVIDARISFTKARSLLPSSADAISASEPAFYVLDPESLAALEEELATESLQCKKDWFNYNGGDATGTVDRKTHKKPLFFDIALNYVELDMERLQERAGKKAIPAQKLVAPQPQRGPSSTVPRQVEQEKTKNPTSRAKVEEIIRPMTPEPSAAAKGLGGLLGGWWGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1F1</accession>
    <name>A0A2R6P1F1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase family 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000561">
        <property type="protein sequence ID" value="PSR83377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1F1"/>
    <dbReference type="STRING" id="98765.A0A2R6P1F1"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="73"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR83377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="332" mass="37514" checksum="340A9E1FA33B9355" modified="2018-06-20" version="1">MGIRTVFTDHSLFGFDDAASILTNKLLEATLRNVDAVICVSHTGRENTVLRSRLYPPTAYVIPSALVADQFKPAVQLPPTDTVTIVVISRLAYRKGIDLLVATAPKICAMFPQVRFIIGGDGPKMIDLLQMRENYLLQDRIELLGPVRHSDVRSVLVQGTIFINTSLTESFGIAILEAACAGLYVVSTRVGGVPEILPPDMISFANPDEDDVIRAISQAVRTVQAGKHDPQKAHDLIRGFYDWNQISERVERVYDAVFETKPYDFWTRMRRTLDLGRFAGPIFAIILVVDCLFFMVLEWWMPSWDIERVQMHWNQERFVEIASPRKMNDTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2N2</accession>
    <name>A0A2R6P2N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000544">
        <property type="protein sequence ID" value="PSR84039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2N2"/>
    <dbReference type="STRING" id="98765.A0A2R6P2N2"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015358220" evidence="1">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="238" mass="26268" checksum="9E92093310448FAF" modified="2018-06-20" version="1">MLPIYTAVFLAITTSSSVVAEQARLSVEYPERVDPSVNFTKLFSQDVVFPHAQWTKETWNGITSYAHTTPLRCFGSDSAIKYDIAIIGALWYNLVGKAHLTPLPQVLPSILPPAIVLDNKVALRQLELANAALLSQSSLRVADGESLAKDGKFHPRVLTLHVGIRNSLHSWDDEEDDYKVGFVISYAEDIEEVGWKGIVQRIRDAVGDNPVYNEITQIAAANIGWEILGLMAKTPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8J3</accession>
    <name>A0A2R6P8J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000521">
        <property type="protein sequence ID" value="PSR86948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8J3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR86948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="206" mass="23123" checksum="EDE96D1FAEA20806" modified="2018-06-20" version="1">MDDFAHERNVSAPPASVNSFRWKHEAMRFGVVLYNDEFKNQTAFITGERCSPRSRHLAGVLDRTEVKGFVMPGDFKVLASIIGEHSVKTVRNSTSREREEEISEGDDLPSLPFLHPPPDPDPGYYLFPLPPSRTRVSGWVVMTPFRSSLVILKQLLPPVALNGWNTTILEIGNETSMRGYLSAQHSHHVGACLYLAIDQQYNSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8N3</accession>
    <name>A0A2R6P8N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000516">
        <property type="protein sequence ID" value="PSR87220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8N3"/>
    <dbReference type="OrthoDB" id="2956939at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="18472" checksum="F8FE146C419AD72C" modified="2018-06-20" version="1">MTAPDPLTSESPSIMDSFVDPRNRFDAIERDAASLLISETDTSMSTTVHGLGAFSGRAIMRMGEYTLRGITGVVIKWKLSDISAKIQRKDPQDWPPGLLDHVLELQRIVLYPDSSRRDAWNLIFIVMEKKYWKPLSEALKIWPYIETQLFLQQLATCKLSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8N9</accession>
    <name>A0A2R6P8N9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000520">
        <property type="protein sequence ID" value="PSR87009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8N9"/>
    <dbReference type="STRING" id="98765.A0A2R6P8N9"/>
    <dbReference type="OrthoDB" id="3061923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="506"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR87009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="549" mass="59084" checksum="1CBCB6FA0ACFEBD1" modified="2018-06-20" version="1">MNMDSSLPTSTATSVPVYSTSSATVLVTSTQSSSISVPTSTPTNSASAASVSSDNHNRAYLGIAFGAIAAIAFFIALVTWFFRIRPRAIKNPTSWPWDADDHHVEDGLGRLHGLGLGNTWATSNVDDLKDPNVYGPSLTLPRCSLAYPSNVVDRDDVLHSTRNVPVPNSPYPTVKLHIAHQSVPDLAPDLGRLQVTNYVPGDVSSEDGSRANSRQGMVHDSDSSQPAWSPLRIRKSGSSPGLAVIDEKSANDITEWPVLPLPGETPSDPLPAPSQGGWASSLRSNLVNAIHAAIGGPGTTPQECLTPAPRRISRQSSRNSAGSGMLSRRSSIRTKLSNRSRGHQNGRDTPASNPFVVDPNDLITALSNVMSAVPEEDIKRPPPALVKSRDRSHIPGPPSLSRHSSIHSAVSLTENKDTSALVLELPGIPSMSRTSTNSSFHQAVQRKALNLRKSRKYPNDRPHRPTLVTRLSSSECSVGSDMSRSSSVISGPLTDQEQFAQRALRERRKRVSAARKGVVKQSIRRPGARLTSRRPRGTVKTDVPSERSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8P6</accession>
    <name>A0A2R6P8P6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000517">
        <property type="protein sequence ID" value="PSR87142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8P6"/>
    <dbReference type="STRING" id="98765.A0A2R6P8P6"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR87142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="12829" checksum="1E8356DF7888C50A" modified="2018-06-20" version="1">MSLSSIEYVIVAGHTNCGGVAITLPNLDDQTKMQCFSPSETSSWPPEEPIATWLGPLRELAIGGGYPTLAALTTANVQQQVSNISQLEVVKAAISNAETRMTGVRGWIFDLNSRLVNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8V4</accession>
    <name>A0A2R6P8V4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8V4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="10103" checksum="FBECEA47BC33BE88" modified="2018-06-20" version="1">MLDECGGLTETKLEVDLELGPCGIETDERDTNDEDMDREDIVDVVNVILWLLEIGRLVEVEDIENGREEEPELGSESGREIDSDIDPEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBR9</accession>
    <name>A0A2R6PBR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000512">
        <property type="protein sequence ID" value="PSR88462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBR9"/>
    <dbReference type="STRING" id="98765.A0A2R6PBR9"/>
    <dbReference type="OrthoDB" id="2742205at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="658" mass="73262" checksum="46CBB52C5A19BDCE" modified="2018-06-20" version="1">MPVLDLRAKKHEVGNLIMELSKDAKRSFVMDTSNKPELYEENIETLTSWLNDIWSVVYEHSVYFTLAHECLLFVVSTVDRIANIRSGCKCALTNMYIPITLRAKSGRRVKTFHITGAQHLDEVVEFIWREMFLSMLASGNRGHRDRIPGMLQDIERMSGWRGVQRILYGGKRSLFDLGYDCETESEDYPDDEVVDDDEDDNFEDEGSDDEFDEPHHCRHWSSRVSNQMPQLQRLIESALIAVFEDAPSTSLYTALLSMSTDTASTEERLLALLKSIATVCSDTYAVALEIYAKQRKTDLILNLLDSHSHLLRSRDAHALQSAVLALSHRGHVQRATQILEAELLETSNAVRQSLLLSYSQLDDEHNRTEISSIIKLRSGAGDRRDRVETWVDNITTPGAETPNPLLFAAMMMGMPPMPGMSQDDDPYTYLDFDPLDPDLEDLRCEFRPGLKQRFESWVDIGVTLRTGPAVLLKVYKDIIDVMPFLRAPDATEEMINRLQDRVSKKYVCEGLDALLAFVKVQRRKWNTAKADLRRRKEAEKMASSSSTPPNNAKPPNIFLGMSPFAVPSASTTPPPSKSQSEAQMSPVPADSPSTSAIPSFFDSFFRNSPSASSTPSLPAPASPPATALSAFGFLFPGTQPEAGLSGPAGGGGGVEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBW9</accession>
    <name>A0A2R6PBW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBW9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6608" checksum="E4D04722D26A47D9" modified="2018-06-20" version="1">MKKESPKKAYKKESTSKDGIGGPGRYVQRVRISRAVAGRVDVCIQKQDLQGLPSFTLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBY9</accession>
    <name>A0A2R6PBY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBY9"/>
    <dbReference type="STRING" id="98765.A0A2R6PBY9"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR88751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7397" checksum="35D12346FC20172D" modified="2018-06-20" version="1">MSEDLSSKYILQTAGFDARFPNTNQTRHCFQNYTDYFKCIAAKGEDFAPCKQFKRAYNSLCPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCV5</accession>
    <name>A0A2R6PCV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v5042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCV5"/>
    <dbReference type="STRING" id="98765.A0A2R6PCV5"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR88893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="14982" checksum="543336FD55D0C506" modified="2018-06-20" version="1">MFGPLGLSLAPVIKANRGIYRWIKPFANWYVNVAGYRKLGLRYDDLLVEERDDVQRALGRLTDREAYDRSFRFKRASQASVMHVDLPKDQWTKPAEDVRYLQPHVESVAKEDNERRVWDTMAVERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGA2</accession>
    <name>A0A2R6PGA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA oxidase C-alpha1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGA2"/>
    <dbReference type="STRING" id="98765.A0A2R6PGA2"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="1">
        <location>
            <begin position="260"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="562" mass="62443" checksum="C1F129EC37DAE0A9" modified="2018-06-20" version="1">MSVTERLRTSELFKSSNASHSSASWQAERAYLRASAIAEAYALSLDDVLSLTPGFWDMHADPILCWDGAATTILIIQYNLTIGTVGRLAENQNREDLLPLLDDLLRFRTIGQFCLTEVGHGLDAVNLETTATLLEDGTFDLHTPTPAAAKFMPPMVPVLGRPCVAVVFAQLIVGKEKRGIRPFLVNINDGRHMCSGITTKLLPHRNGSFPVNHSITSFRHVRLPRGALLADDIEKSPSEHFDFLMRIWRVSVGTLSLSLVAMSTLKIASHIAFFYSKRRTVGGPENSRIPILSFRTQQIPVFTAVARAYVLDAFSRRAIQLFMDDSLDIRVRHGIATCFKAATLHCAQESAILLSERCGAQGLFGHNQIVTQYSEMRGIAIAEGDILVLSIRLATELILGRYSMPHSDNSRSLLSKHEVGIIAECQSLTTQYGHRSEEFATRVLPKCQFLVETIGHRIAYDAAVAEGVPTSLIAIYEADVIKKDLAWFVEDGCISRATFDDMEVDAINKASHQMEEWVNGMKTRTYVTAPITSADRWDDFVAGLETFSSVRRERRPLFRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ94</accession>
    <name>A0A2R6PJ94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ94"/>
    <dbReference type="STRING" id="98765.A0A2R6PJ94"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR92209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16167" checksum="6EB14450E3641E52" modified="2018-06-20" version="1">MTDPLARSRNSREVLLNPLTISRNENERVLIEPSVNSIRLSIKIKQADEIERILCHKFTRFMMQRAESFIVLRRKPVKGYDISFLITNNHTDTMLKHKIVDFIIQFMEEVDKEISEMKLSLNARARVVAESYLLAFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMY3</accession>
    <name>A0A2R6PMY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMY3"/>
    <dbReference type="STRING" id="98765.A0A2R6PMY3"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR93785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="421" mass="45602" checksum="77E3CE09C4AF7EBE" modified="2018-06-20" version="1">MSSPPQISSHIDIEKTLSKMTMPDKAKLLSGLYTTTFTPDEDGDWDVSLSLAGKGNLFVDGKLVIDLSTDPQPGDSFFGLGTSDVRARIPGLKAGKGHAIEIRLGNADFIARGPPFFTRGGIRLGAVCNVGDDEGINAATKIAKEADVAILIIGLNNDWESEGHDRENMDLPGSTNRLVSKVLEANKNTIVVNQSGTPVEMPWEDKAHTLVQAFYGGNEVGNGIADVLFGKVNPSGKLPLTFPKRLEDNPSYPSFGQRNEVYGKVLYNEGIFVGYRGYEIKKVAPLFPFGHGLSYTTFKYSGLKIGPISDQGEFTVSFAIKNTGKVFGREVAQVYITDPVSSLPRPLKELKGFTKVALKAEEEKTVSVDFDRHALSYFDERKSAWVAEAGKFTVRVAASSVDANELVGDVELASTIVWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN45</accession>
    <name>A0A2R6PN45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN45"/>
    <dbReference type="STRING" id="98765.A0A2R6PN45"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="456" mass="50696" checksum="3CCE222DCA2BD991" modified="2018-06-20" version="1">MANDPDFTDITDKVLQDEVEHVASHTGRSQYGPDGGGASSCGLAAFNCARVVLQTEKDGLQGPDLIQAMMRRDMFEDILAICSHWSSSAHLDVDDIYNAPIFAANLTLIWSEYEQPGFKQFQDLLVRLQQVSSSSGALILTRPPEIISVLNIHTDSKPVIVTFDSHPRSKHPDGAAFIFHPTLNAAASYLSDLLQFDPQLLADPSLQWQAQLLAHYSAHMFVAKDLPTSSSEFLDTLVAASLEVLALKAEITELKSRNRMLESDTKHLTAENAQLEARIEDLEEDNRRHVRRATLSEPTPGVKSTLPSTAPRQNPGPSNSITQTVASSSSSKGTLIFRTTELEEDDELFATRIQLEWQEQVDDGAKFAFQRQKEYEEEDELLRSQFVSLKQVVPASFKCGICLEEETEFMIARIDPCGHSFCSAILAQQIGLNEEEYALFTELELGAFSVLLHCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYX9</accession>
    <name>A0A2R6PYX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYX9"/>
    <dbReference type="OrthoDB" id="3050153at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015310917" evidence="1">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR99060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="178" mass="18564" checksum="6CCDBDBBDE5737EA" modified="2018-06-20" version="1">MFNKALLLLPFAVGVMSVTLDVSFFSGASCTGVGMGCTDIESDACCADYNTSAAWQSLSTSSWEGIASNTYVHAMAGKTCSVNVGTVSSAGACFDSGSATGITSAIFYNGAGTALKKRDDDAECTPHPADFYFYSPGDGFKYIVDATNPVHSTNINSATSSEEVEQYILANFEKKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7J5</accession>
    <name>A0A2R6Q7J5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000384">
        <property type="protein sequence ID" value="PSS03522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7J5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6310" checksum="E09E1964D76579CA" modified="2018-06-20" version="1">MSDTDADSTEIDQYIDLYRRLLVENYCILATSGMCKRCLMLERCQLVAPDGSYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBE9</accession>
    <name>A0A2R6QBE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBE9"/>
    <dbReference type="STRING" id="98765.A0A2R6QBE9"/>
    <dbReference type="OrthoDB" id="3190515at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="849"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="890" mass="99210" checksum="1ECC466E51AF7F87" modified="2018-06-20" version="1">MSVDPRILEDVQRALKLKARREARLKTSQSHPPLKDTVLTSDQASSSSFSTHSSSALRTNPPDFQQATTQPAFGSVESDIDFSPAVGSIPLHPVPSSSNGGATLDWTGSGSEDERDKRWALHITKRKPKEKHSVYANRIVVEKQESLYADRLAVIKAKVKPHTLRKAAITAEQVQRRYAVLLGSSPVRNASVNLLNAARWYSKQESVVQSSLDHAEPLTWLKHLLEKRSKASSSRLPWHLTALIIEEFAKSLTRPEMMETIPEDAALGTSSHAPDSSPFVAAVVSHDAELPSKSPSTSGSWSWSPPPQSLEPSLSRKRRPSYDGPVSFEPKVDSGRESVGGDSRRSSSDPASKRKQSLTYGTDSPRSSIQSGALNGSWNYGMSPGSSRMHLRDIAKRIRRKPHHGSDDGLSSGRNSISEHSHEDDTRPAFKGRSRSRPLSIQMQFPGHVVESEEDHATRSASDRALSSGGEGPLTAKQAPSPYVSPEEPTVKPAERITSPDPHTPPPQLQPIKLRSPVSRRPRRMSLPSLGQLLSNEQAKRQLQADEEQERNEYDHKTQLLEDTMAQNHRTRQLLQRVGANVREYDNVQSRLSLLLGTPHSPIPLDVLDAFSHDPASVTSGTKRFKSWRAVEDISDRINRQRETLLTFATSFSLREGSGSTTPSSVFDGQIATVSHSLEQLEGHRRHLAVEADEVAETLARVKNIHSTVKKAYNDVLSHTSLIYPELSQVVALEESYRNKYQQFWDIGLDALTLLLDTVTPVWRNYGKVIGEDVQDFLIIPWYRNEFTGEQRRYPIAHLPKRPVRHWLGLLVFSVTSICIVLLQMGAAVSSTLNYNLPWIAHTGFRWMFIPIFSIGLIIQWCAVLIECAIVFAEIGVVTWWLGWAVKIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBK7</accession>
    <name>A0A2R6QBK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBK7"/>
    <dbReference type="STRING" id="98765.A0A2R6QBK7"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="399" mass="42577" checksum="5DA1B3B05C2B412D" modified="2018-06-20" version="1">MGPAFGDSATSSVKSEKSFSSPHKAESPVDVAPPVAAFIAPKAFPPPRSITPRPSMENLRGSRPTGHGRQKSAGSESMRHLIPSQQGHSHTASTASVGSTMTTESINRPIASMDRLNQMVTVPLPTAQKSSLRVEIGNVSDSSLSLPAPPRNTRSPVLRRPTLPSIASPPLDNSMLSAVPLKTPLPGSDNAGASQRDSFIKMYASQSALPQTATFMPPSMFVNDGDRITMPTFSPGSNSSPGFSSDSDSELPRSAFGERVVRPRPSRSFRVAVEQRLSTVDVPESGGLSSLAWATLVTNAATSNGGTDAAAKMKASRRRSKSMESLRVPSALQPRTPISAKLRRERTMGFVPPRSAMGESRYPSNSIATAMHRESRATFRDGPSKTPTYKTSSETMRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QER2</accession>
    <name>A0A2R6QER2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QER2"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="255"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS06641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="532" mass="60341" checksum="C984D4A3F2586E8C" modified="2018-06-20" version="1">MLEHTNTTVHPYVRQDIACAKSVPYHVWTDAILKLDKKKLKKWVAQIKQREWRSDPVIQEALIQFCGASKETERYEPYVQIINRILELAKDQLAGLDAYPIEDIKITRNDPKYIERIPEQGVLGALRKPDLLIVGKAAVERTVLSSTNARFHWSDILTFVELKAELGLLPGLNAWRVQQGLPEINTDTLKPRTEARKGKSRKTASLSRADPTCTTHNLRDTVVSSSEDGSHMLPSTSKRRASPALHAPVQEDRSRSNSSTTWKRVRPHDSLDLLHISKKSNTSGVVTLDATVQAGGYALEVASCTYGTRLFCLGIVMEDDRLSLWYYDAVGVVRTQETLSIIHDFETFAAVHVGFACCEPSQWGAIPPVIKPPPSAAYPEHFPPLSLRGYTFDTSVRSTGEKVTITLEEPIFSQYNLVGRRTFLYAIKTKSKTLKKPMIVKFSYQVTTRRPEQDFVKIAREAEVGHLPEIHMWEDLWKMSDGVRAAFHEKSNDYEDRILRALVYTQYLPLKELFSKSCDLIPEMVNQMLDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3W8</accession>
    <name>A0A2R6R3W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3W8"/>
    <dbReference type="STRING" id="98765.A0A2R6R3W8"/>
    <dbReference type="OrthoDB" id="5550090at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS19944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="237" mass="25846" checksum="C5CDCC815E69E6FE" modified="2018-06-20" version="1">MSPSKSPVKNIKVKVPRHNSQRIGPVLTAQVQALARKKKLRVDVGQTAYDPASILAQATDSASDWNSRLMTARAERGPQWDIGTQQFLVDEGSDLYYDPTPLREYEKEGRSAEENERNDRASMPPPNSLPNPDSPQLRRHPSHALQAPSMPYSPRHAPQFSQGMSSPFGGMQPVPAAQFYGNGDMGMRMGGMSGMHMDGMGMGNMGGMGIGMGSPEMRRGLMRRGPMGMDDGFGGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIA7</accession>
    <name>A0A2R6RIA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIA7"/>
    <dbReference type="STRING" id="98765.A0A2R6RIA7"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015357278" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS29745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="446" mass="48263" checksum="28F96C3D7A38C3B7" modified="2018-06-20" version="1">MGPFNFLAIVLLFACLVRASSDSSTNTLSVHLTSGSFAGESLAANGTERWLGIPFAQPPLGSLRFKAPVAITRPSQILRNATQFGNACPQAASAGLGASISEDCLFLNVWRPSGTTTRDKLPALVWFYGGAFMDGAASDPSFDPTRILARSVTIGKPIMFISVNYRVNTFGFLPRLVKHEPQLASSHVPTEDLNAGLLDQRAALTFLQDNIGMFGGDPAKLNEGTSFSQSLLNLNTPSAEEDAAFVTFIKDLMIDPSTITNSTFDTLISLYPANDSSLGGAFNTGDSLYDRGEAWYTDNMYLSARRLLFAKAAPLQPLFAYFFEEFIPGNPTDLGVYHGSELGLLFGPVPNSIEDDFANQLTDFYINFINDLNPGSQWPQYELSTKKVLQLMRNNVTVIPDEDDIPQLCCGPGAVSKIVSRSQMFYAASLENLSVNGSSGNSMPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPQ0</accession>
    <name>A0A2R6RPQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPQ0"/>
    <dbReference type="STRING" id="98765.A0A2R6RPQ0"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="377" mass="40928" checksum="5D5D950B4D40341E" modified="2018-06-20" version="1">MTLEELVLLPLCGVPAHRAIRTLADVISPSKTRPNAEDPHRRQPRVFIIQAHDGPGAMAVQMLARRGVNVCVQVPDSAARDDTNEGDDEDTDTPVTVRRSPSSSTKAKQTRYDRLEARLRAWGADEICVGEPLEVLERMIEDGRSFDGVLDTVGGAEIWERSRKILLADPELDPLLQSSPLSPSTPTTPGTISSSGNSHSSRASSNSNKRGFTMTQFTTLVGDTPSRPIPTAHDNLRSGFRSFGRSSSTGSRSRSRSPTRSLAKSSTSVLSSPSKDSLGPLLRRNTLTRVKAQKRTVSYAWVCAAADVDFEGEDVRDSLGALISMVEQGWIRPWVGDSREGSKVVPFDQAPEAFRRHGDEIVGLLKDGGTCIVKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPU4</accession>
    <name>A0A2R6RPU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000202">
        <property type="protein sequence ID" value="PSS32048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPU4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6698" checksum="D7F4C01F8435C914" modified="2018-06-20" version="1">MSRTSTVRDRSPFALSVRLSLDNKPETAGVSHTGGSFSVRGESQVDRLVHRTVGEKAALDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPX8</accession>
    <name>A0A2R6RPX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000199">
        <property type="protein sequence ID" value="PSS32077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPX8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="513" mass="56940" checksum="47B2363FBB9952CF" modified="2018-06-20" version="1">MSEHQYSTGYTDVTANGIHGYPSQSPTIPLVGDTLSQAFGAGPWHNYPTPILFSEQITGNDAFQPQDPFCSIFQSVLTVRHPLVCRFLGSLPYTSPEVGMQTPFCDSAERRAMAGIEEIGQDWDKPLDVNHVLGVGLPTEEAECVFVLAALQVLLQCYHAAHFTLWGTWRCASTAQRVNTMLGEDFSVCLNAYTQSLLMLIIEAKPCPIVVPPWITWAGVREQLWSLHAMHEDLFPAYIPSKIELRDTTNVEIADTFRHADRSNTKHLENQHPTEIKGLKRGSVDLMCTWDDDIHERPRKKSRISDTIGAHDHTVLTSVPGLSSPQTQVKLELTDDWASRPLSSLEESTCPLPTDSKLRYSVPLPQCRRCKPGKLCSSSTAAGHSDSEDTYVDSDVDSDHGFGAKYGGKRELTPLEMNVPLRESSRLKKMAVSLDEMAAEGESIQLESGKVVGRKKVRRSDKTSEDRARRTHGLGRANKDSSAGIKQKADRQFTNSRRSKRISLRLAGSHLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ07</accession>
    <name>A0A2R6RQ07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000196">
        <property type="protein sequence ID" value="PSS32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ07"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="288" mass="32357" checksum="ABBB704FF24EABA6" modified="2018-06-20" version="1">MLDVGCEEISFLLEPVAHRREGKFAAHLKTIVIDIVSVFSNVEDAIVCDWNAFDNCVSRLSRLHKIVLGLYPQEHARLRFIHEVVNTKMVNLGLAAPGRLAYAIYGRDQGEDERTGDNETSDENTADDQAQVIRIPEIPKWMRVAPGSDELEDSVPPIVFSPEAAYALPQPGDVRLRNVAALEAHNERNSFQTPIDAVELIDDGWMITAVSRFIYITPDLLRRAGTGDKMRMKGIYNILSFIFVLDDPESFFGQRIDESMSAVTMPRGLHAIEELSVQRRQKLPPLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ66</accession>
    <name>A0A2R6RQ66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000195">
        <property type="protein sequence ID" value="PSS32139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ66"/>
    <dbReference type="OrthoDB" id="2802668at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="13011" checksum="87493D98561C9857" modified="2018-06-20" version="1">MPALPPEVLYDIIARITAEYIDDVVAGPLSMPRQDIPSIMDQQTGNQNDEEGAAVNLEQQVLFGLLPDQLTPDLDEDDPVTNAPNPIIPLLTVSYQYRRTTLKVLSDALGIPLNEEGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVZ6</accession>
    <name>A0A2R6RVZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVZ6"/>
    <dbReference type="OrthoDB" id="3261714at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="464" mass="50928" checksum="AB7D6A6827FDD2C8" modified="2018-06-20" version="1">MSARQPFIPQQRPPSKPNPSEASADESFRPNGLLSDSSNTSTETNAPQSARNGFSTSLDTPPLITGAHKPLNLAGFVKKKSHGTVHTSGKAHQVIDDHSSSSPKPMNQQATRIVAPSPFFPSSSGFAPIAAFRTPSISSSKLQTSTSTDEFGSNQPHIPSGPAQDGSNNSDRYSQARAGHRMRPLSQPSLERIYEIEEETPPEYGIQGPGAGDGQEIIRNSSTAPEGHARYESDGKEKPPPLRRINKRPQRNEDVEDELDYGNPTKRYKPDNLDEEQSGYYSLQPSPRPQYDHQDSHTPTFAHDIRDQTVEHALSRPVYTGRDPKEASIHHEHALHRLLGQELDAYVDTHLESYEQAKKKWAQCSMDEWKTGADGQRAHDVRPIEVSSVHPLTLTFRTKLALHASLHSTLAAHRTVLSDREDTLKEVRTTLVREGGNVVSGKGAASFGGNGNEDELVLSKDGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZG6</accession>
    <name>A0A2R6RZG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZG6"/>
    <dbReference type="STRING" id="98765.A0A2R6RZG6"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1-type" evidence="4">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS35421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="526" mass="60018" checksum="B2A48D6DEAB4A115" modified="2018-06-20" version="1">MDSIIELQRQTHEEIEHYERALYTILSKSQTTHETRLQTEHKASQILDRISSRVVTLNNFYQDQESRKAEMDLLSSATNPNDLSEFYTRFGKIQEHHAKYPESAANGFELELAVFLDDAEEEAGDEEYEEDDPIALLFSGEEQYGKYLDLYANHTTYSNLKNLGKRLGYLQYLDVLLASQSVTVHSELPKECRLSRDYELYIKALHTYLVSFSKRAQPLVDVTSQQREAETMFNKKWEAGEIEGWEEIRQKAVAQAEGNGEGIWCSACQKLYSKQTVYDAHLTSKKHVKAAAKQVESGQVPPNPNGPSASHSATNGSGNGQDASSKQSKHRTAALLTHLSTKLLASLATVLTDTKSNVERRFSLTAREREQELIEQSKPKPAAAPTTASGEAAEEEEEEERIYNPLKLPLGWDGKPIPYWLYKLHGLGVEYRCEICSDHVYMGRKNFDRHFQESRHAFGMRALGLPNTKHFHEITRIEDALALAEKLKREGRNEIFEQETMEELEDEEGNVYNRKTYEDLKKQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZP2</accession>
    <name>A0A2R6RZP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000124">
        <property type="protein sequence ID" value="PSS35498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZP2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="250" mass="27687" checksum="1487050738BFDAEE" modified="2018-06-20" version="1" fragment="single">TVVRSFDSERDDFMGDFHSYIPPVSDYGFNIPIHAEHYGPTRKESGIAVLILPPDLIRRAAENGDVIYHYSELSRSPKRIRRLRAASNASSTSIPSSQTNESELVWPSTMRPLFIVKTEPLVDSLSAVEPTAPAIHPTAEDSDSETEPDLDADDADAAVDINVTQREPTAPAIHPTAEDSDSETEPDLDADDADAAVDINVAQREDQLCQCREDVIVLMKKIAMHARETSFATDGLLEFLRLEAAHRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZS9</accession>
    <name>A0A2R6RZS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000120">
        <property type="protein sequence ID" value="PSS35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZS9"/>
    <dbReference type="STRING" id="98765.A0A2R6RZS9"/>
    <dbReference type="OrthoDB" id="1932208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="20613" checksum="EDA04ABA0F3FD2F3" modified="2018-06-20" version="1">MAELMRVQLMCLQEIHFKCVIHADIKPSNIFLHVQNGSYQVYLIDFGYALIVNERRVSSQNEPPPGSAAAIRGGTILFSSINWQHDRPISYRDDLESLVYTLLYLRFGQLPWWNPRSGHIVLDEDVVEKLKQTWVDLPWAPTELVDLWHYARELRVDEKPDYDYILGTIFRDDKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3B2</accession>
    <name>A0A2R6S3B2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3B2"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="10"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS36770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="296" mass="32370" checksum="2FD64779F92901C6" modified="2018-06-20" version="1">MPIFDVGRAHRYLPYHGLQFVEAILGTLVSVLCNQALLVSVGVSAEGSIFGAVAVQWIIKDGAGELAKLFFIRKYSSFFDSHPKTFNLIGAANVLFGSGLQIASLIVPSTATYFLLCAAGGNVFKMIGGAFWFTTHIKFVRCFAQQGNTGDVAAKSESQASIGQLLGYAAGIGLLAVSHSAPYLYSIFALTVPAHLAVTAWMLRVATFELLTLPRLSHLADEFVGNREVVSLKQLEAEKKTGLFGEFYKRKENAYVSLTPRLEDIITTDSLKDRRIWDACMHAFDVRILLSSYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S452</accession>
    <name>A0A2R6S452_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S452"/>
    <dbReference type="STRING" id="98765.A0A2R6S452"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="364" mass="41130" checksum="AFE94C9513059DCA" modified="2018-06-20" version="1">MSSDEQPFNLSVPQDTLDTLAKKLALATLPCSAPTTYTDSEDTQDWTYGVPRPTLQRLVHHWRTSFLPNWREHQQTLNAFPQFTRSIEIDGHGVFTAHYVHKKSEDRQKNAIPLLFLHGWPGHFNEASKLLPLLTAPPASADYPTFDVVVPSLPGFGFSSAPTKTGFALPQYAEFAHKLMLDLGYNEYVVQGGDWGRHIGLCLAHTYGPKHVKAWHTNYPRAGPPQLLRNPLLWLQHIVTPYSAADREGLKRMQWFRNEGTGYSAIQSTMPQTLSYGLTDSPVGLLAWIYEKLVLWSDAYQWGDDEILTWVSIYLFSASGPATSARIYHEVKHSSRSQELINIWSPVPLGLSYFPKELTPVPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4H4</accession>
    <name>A0A2R6S4H4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4H4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4H4"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="116" mass="12567" checksum="C4E466B62F21E02F" modified="2018-06-20" version="1">MNEGQLRPAWFDAFHLPPCGSCGVSGISASVARIEHIILAEMQILSQPNRVVVAGFSQGAALSMILALTSLHDLGGVVSLSGWIPRRCRQTYNGLDHSIGDQEINDLVQWLQDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4V2</accession>
    <name>A0A2R6S4V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000067">
        <property type="protein sequence ID" value="PSS37296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4V2"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="14671" checksum="BE0AA8513C1F1CC6" modified="2018-06-20" version="1">MSTAVWFTLEGVTEALASELDPEWNIKVDAFEIWRDDAYGVLRQADYPRGVWRFRVERQRQRGTGPPHAAYLKPSLASTNSRPYFLDKSSTMSGDAGKAIARVYDLAQLEDPPLGLPLGNDGMSQRRRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5T3</accession>
    <name>A0A2R6S5T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5T3"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="6022" checksum="D192BC3AA4BCE4A4" modified="2018-06-20" version="1">MGIITSGHTKSLGDVFETLVGAYYTEKGFHALHEWAKRTYEPIIEAAVRAYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6F7</accession>
    <name>A0A2R6S6F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6F7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7775" checksum="5C101C5A4C4E5298" modified="2018-06-20" version="1">MIEIELNESLRRRRDELRGKIETLSAAEAGDASAADELENRTRELKALSNDTCHGYMICDAVCWECWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6W3</accession>
    <name>A0A2R6S6W3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6W3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="115" mass="13198" checksum="6DA20B799C407978" modified="2018-06-20" version="1">MPVLRSGTCTARNVSALPVAPGRARKVSRRKIKKPKRARKRKPDIQWSTPWMGSLPMTRYESKEKRKRLLANLSSPKSKKSFEGVSQVAMSRSMAAWLKNSAPLKRKKRFICDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S744</accession>
    <name>A0A2R6S744_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mannosidase Ig/CBM-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v31</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S744"/>
    <dbReference type="STRING" id="98765.A0A2R6S744"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="2">
        <location>
            <begin position="213"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS38124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="387" mass="44150" checksum="3669D3413388BBF3" modified="2018-06-20" version="1">MPYHPGSPYGGQGYDTADPTVGDIHQWDIWAGRERPWQNYGIMGGRFVSEFGIPAFPDIRTVDYWLDGNQSERWAQSKLMAQHNRAGAHERRFAVVMNENFRLTGDFETHIYNTQIMQSEAISLAYRMWRREWRGKGKEYCAGALVWQLNDCWPVTSWSLADYFLRPKPVYYTIARELKPISVGIFRTVVKNRDNDRPLQFYEFGAFQSISASIEVWGTNSTLKAQALTLELRCFDLQSDWTYAQTQQVTLYPNQSTELLDIPCPCPPRKEVEIDNCTTTSHSVIVQVRLLDTDTSEAVARYVDWPQPYRYIDFPDPELKLAIDGEQVTVTVGKPIKALVLSLDGEGESQWSDNALDVVPGDPQVVTVRGLAGRNLRAAYMGKEKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U7KT05</accession>
    <name>A0A1U7KT05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001214">
        <property type="protein sequence ID" value="PSR72098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U7KT05"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="9140" checksum="650EA84D4F88D46A" modified="2017-05-10" version="1">MEIRSDEAVPRALPRLRYSSMHLLPYFAPIQRASFINKRGGDAVLSEFQRQTSNQLRKGSTRSSGNRVGQECPSDSMKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDZ0</accession>
    <name>A0A2R6NDZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v13585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDZ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NDZ0"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR70546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="282" mass="30890" checksum="8D113B74734ECE23" modified="2018-06-20" version="1">MLGILDPVTRIFPFARGLFEDKVANFWCASNVAFKWKIWMSRETLVKLSTALTAAGFLPSVIGLIYSGYRLGASEQPSLQASKEKSAPPSMPLLPLLPMWPLLKRDGLALQYIVAIVLWNRLIGYNPFRQGSKSLMQYASLAIYAACFALHLIEARMPPPTHLPDLYSVLNVLISTPVFAFTWLWSIKRGVEVGWAIGGLGSKSPAGGSALLTPSASYADGDKHFRSAAEIPSSGSSFSNVSDKSLKRRSLGFAQGRKINVVSPLREDICPESEGHEHPVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDZ5</accession>
    <name>A0A2R6NDZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001347">
        <property type="protein sequence ID" value="PSR70583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDZ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7726" checksum="C66470BCCC7C5E0B" modified="2018-06-20" version="1">MAEGLVARPGVDGKWEGEWQWNIVPMGTHCVNRLRGRLDHINENVTVFEVISKSTDVGQEQLKYYPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEV9</accession>
    <name>A0A2R6NEV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEV9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="111" mass="12313" checksum="BE4EFA95FBBD5506" modified="2018-06-20" version="1">MVHVYFNPSIAPVLNASVTSFCQIALQPGASEDEVKAERERLVGSPSVHPVSASWGRAVERAEYILAEGWEETEAKHAQAHGHSKVEETSIAENAFRVALATYKRYEQKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF89</accession>
    <name>A0A2R6NF89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v13019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF89"/>
    <dbReference type="STRING" id="98765.A0A2R6NF89"/>
    <dbReference type="OrthoDB" id="2802627at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="158"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR71050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="413" mass="47183" checksum="41A838EF363DAE4E" modified="2018-06-20" version="1">MGGCERISRQDLQALLAVQSANIQVAASFYDDMVDETVRLEHLFHNWLDEDEDNLTLDSELDELQATVLRQTGTDITLVASTLSEDHSQGPYDQIAKCGEYFEKALSWPDRDFRYEFRVTRALRELGLELLTWGDDDRHAQSKLHFGQNGFHGCIGIVDGSLIRLTAAPPEQGAVFYCRKKYPAVSSIHWLVSGKKVIISCQINVQAVVDHEKRFISFEAGWPGSVNDVTIWKKSHLWRHRHEFFKEGEYILADKGYPSSPYLLRPFTEPEVNACDELEKRRRRLFNRNLSNKRIYVEHAFGMLKGRFPALKLLGTPEDIQNAYRVVQALMAVHNICLDMGDRPEHIREYDPNDLEIDGVIDPLELLRDVELSHYGGVVGDAPVNIPRGETDDTLRAAGYEMRMKLLDEIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFU8</accession>
    <name>A0A2R6NFU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFU8"/>
    <dbReference type="OrthoDB" id="3215388at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="13165" checksum="888295D6DFF97245" modified="2018-06-20" version="1">MSSSSYSTSTSTLTSVTSTISSTSTYPLKGNSSMMRSSKDYEATFGALQSIYGFSGQATCQPAPPKPFKSTSPKQQRSQTVAQSSSSVKSSQPKDYEAAYGALCTSYGFGGSAFAAPNGRSSRSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG24</accession>
    <name>A0A2R6NG24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG24"/>
    <dbReference type="STRING" id="98765.A0A2R6NG24"/>
    <dbReference type="OrthoDB" id="3035352at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="132" mass="14081" checksum="61E442412F40E87C" modified="2018-06-20" version="1">MPGDETTNSGTTILPLAFLLPGMKQNQYIFSMLIINRYLLGQDTNFPAVNFNSWNVGAGQHIDVSGNHGRLVYYSIDASKALIPIVSSLIRQIDAASTVLLKNTNSALPLKAPKSIGIIGNDAGSNPNGPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGG1</accession>
    <name>A0A2R6NGG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGG1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7675" checksum="8D4C40099B3F82D7" modified="2018-06-20" version="1">MSIRVFEYEKYEFFRALQCRVTAVILKRRASSVRVNGSTPGRLKTLFDRGVEGEKLRMAHPETKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGS4</accession>
    <name>A0A2R6NGS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001262">
        <property type="protein sequence ID" value="PSR71587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGS4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6200" checksum="572D271D0BD9B2D4" modified="2018-06-20" version="1">MVIKVQDVIFPRTTVALRTAVATVATGNPPCTLSFHPAGMRIFFHGMSQPAALIFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGS9</accession>
    <name>A0A2R6NGS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001260">
        <property type="protein sequence ID" value="PSR71595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGS9"/>
    <dbReference type="OrthoDB" id="2803586at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="909" mass="100771" checksum="CFF64EED6126BF3F" modified="2018-06-20" version="1">MPKPHMFEKYPTRLQEFRLTADGGYGENCITDDFVTDVYLEFDKRTRAEESADYLRTLSGISLSLDATFKTANKATLVNTQKVCVCLTKGGLLTIINERNEIIAWTQSNAEIEELLSGLARRFELLGLPLPEQVVADNCCHIRTMILKVLPSSHVCLDIWHCIARYTVVVLNGKKNPYLTSVARDISSALLKSRGSHGVLAEYRNRDEAETMLQAVYEKYSRIGGVWTAAAAKVHADQLSHVKKGCLERRRQDIAADGSRIEGSHKAWNALRRACASGLEMFGALSRDFVLRRNLRIITTTGCHRGPATGFAATTQGSHHIRLQNWINTLFNMLADRERTWGGPELPAKPILQKIDSRETFGLVVSDHNLTFGGLLQIKDELDEDRKLEDLLSEREEELDVTTVLHDLNIDPALLHQPEPSGCTISHRPFHPSASPLALGGTHSSITTSSSGPSNVDGLLGSLTESSSSWDNLADGHCSMEGTLERVEMKALTSAQVVGDLIIDLTKESEEPTSTKRKQATLETVAGLGPPVKKLRTQAPVTQNKLNATSKAGQLQLSPFFSDQRHAVMLGVPDDVAKNLGSGSAPDLPSKTPPVPCQDKPASPSLINMLSSPLPVVHGPDVAGSNLQHLSRSERLFALNTGMNPQSLQINSDIEFYAFMDLRLEHGWATYKMNSRRYVEAADLYNNRLVQVNEGEGIQLTIKKRPRAIAEKLAKIEAMCSQRIIAGNYASKRNGDEAFWRKHCHAVPLGTDPAKQNNGKARKLQTCARCQKIKYIGGLGASGNHRKICCSDGVKTQDKNDPPPKWPQPEGVFTNGTHFHLLAFLEQLRRLYEKAIVECDTASEDMESEAFFELLKARLGTMDVEKDGKTLQVPVFRLYSYLMMSPPLDQLVMTRDSKQYLRVDCLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGY7</accession>
    <name>A0A2R6NGY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGY7"/>
    <dbReference type="STRING" id="98765.A0A2R6NGY7"/>
    <dbReference type="OrthoDB" id="3219836at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="206" mass="22426" checksum="0A2C201E406C826C" modified="2018-06-20" version="1">MPVPEPLADPRHVRPVLGHVNLMVDTFLANSDVDDLRAVVRGLLSASPPSVASAFTAAAQRRLMQTNAAAVPSTDGLFVRRANDGEIVPTLELRNTLKRARTLYGAGLGFASLKVLAQPVRATLRFHWEEGSELESFLAEIDADISQALQSSREELDSGRVADIAKARDAIGDLRAAVKESQRAVHNWGGVYPFERASATLEFWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH73</accession>
    <name>A0A2R6NH73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v12385</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001245">
        <property type="protein sequence ID" value="PSR71737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH73"/>
    <dbReference type="STRING" id="98765.A0A2R6NH73"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="133"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR71737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="245" mass="26267" checksum="D716D33C77938023" modified="2018-06-20" version="1">MTEPRIAFKAGRAFRRGGSNFVDPSSTKGAVILQNGEDGLLHFVWKNRVTQENEEDADTSRDDEFVGNVNRLLADPDSIPIWYAPGYNPSNAQAGPSSGDAPSSQPPAGPSSIPAASSEQLTQLQEIMGSVTEQAGRPEYLLQDILTPANLTPLFISHPELVPTLFPFLPSDLPTPPSAEALQQIISSPQFRSAVRNIDVALSTGALHGFVRALGLPEEAGTGFDAFLRAIQDQARERGDGMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHI1</accession>
    <name>A0A2R6NHI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 105 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHI1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHI1"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44668" checksum="09AD0B6B96C91E24" modified="2018-06-20" version="1">MSLANIDPQRVEVLKTIQSLINCLVNIKDETGEFLMTLEDGRVIDTKGWNDWEWTHGIGDTSSFANIARVDIYPGLYGLLKFHEITGDIEALRIALTWFRDRFAVGTTKNVNTMSPLLTAAYLHEAKHANYAVHLDSWAEWAMYEMPRTQEGGLQHITYLVDNHQQLWDDTLMMSVLPLAKIGLVLGRPEYVEEAKRQFMLHVKYLADPTTGLWFHDFSLEFTAQLGWTFDGRHHFARALWGRGNCWITVAIPDFIELLNLPPSDGLRLFLVSTLTAQIDALVRLQDQKTGLWHTILDDASSYLEASATAGFAYGLLKSLRLRLIPREERYVRAAMLAVSGVLGKIAANGELQQVSFGTPVFDDIEGYKQIPLTSMPYGQSLALLALTEYLRTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHK4</accession>
    <name>A0A2R6NHK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001238">
        <property type="protein sequence ID" value="PSR71864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHK4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="166" mass="18205" checksum="DA7EED51889FA4BE" modified="2018-06-20" version="1" fragment="single">VLDAIRVPKPVIETDIRVIVFSALRIFAICEHNVPVSLLVLVLNLLPAVADILNSGGKSTAYVEPIEGVFCGYTLWQLPADDPGANWVFRPLSTPILISRFMLNLRQVNTAQNEMQNTLDSCFSALTFRVPTLTSFIGNMGEDLYHGAEAGEDIAEESDIEILDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHZ6</accession>
    <name>A0A2R6NHZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001229">
        <property type="protein sequence ID" value="PSR72017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHZ6"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5703" checksum="7D90568A60B7C727" modified="2018-06-20" version="1">MTDGLLTDEQLKASVPMQREGNIDDMAGIILFLANLKTSSKRKYGIDLYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIB6</accession>
    <name>A0A2R6NIB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001223">
        <property type="protein sequence ID" value="PSR72041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIB6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="10991" checksum="806AEFA10929506E" modified="2018-06-20" version="1">MSSKNESKPVALERRRYLLNQRMQFSSMIFKSAVRNEVAQLLVLVLAESPVLAGKLSMVAWKHFLTTLDKDLNTRSEPDGKDTENKTLSMRGATHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIC5</accession>
    <name>A0A2R6NIC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02001223">
        <property type="protein sequence ID" value="PSR72051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIC5"/>
    <dbReference type="STRING" id="98765.A0A2R6NIC5"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF452">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="24438" checksum="2ADD9E4F88EDA6F7" modified="2018-06-20" version="1">MGLLFELGPCTIANEGENTTVNDHGWNTYSNLLFLDQPADVGYSYSSGGVPVDNSPVAAEDVYAFLQLFLSRYPEYESAPFHVAGESYGGTYVPHIVSEIHRRNKKLDVSDGGSPSTLRKDLKKIHLESVILANGLTDPYVQFGKIPEYACEGPYALFKRGSPECDSLREKARTCQRLIQNCYDFQSRLTCLPPTHYCTNQLFEPFSSQCQSIAYVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIL9</accession>
    <name>A0A2R6NIL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001200">
        <property type="protein sequence ID" value="PSR72226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIL9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIL9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20352" checksum="198BD302881AAA17" modified="2018-06-20" version="1">MNYHRIPSAHLVLAERSYSYTGETYPLFLPIPPLAPVAISLHESVRFALNSSDAVADGEWDSLSNDLPGLGRMRLGPERRVFAISMFHQLHCLRELQRSIVHREDTRNSYHHVQHCLNYLRQSLLCTAADTIEPGDPMLSDFETGGVGPDLGCQDWEKVFDAIVENKKEFDEWNSRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIQ7</accession>
    <name>A0A2R6NIQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001201">
        <property type="protein sequence ID" value="PSR72223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIQ7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="195" mass="21926" checksum="DA0A351274CA4336" modified="2018-06-20" version="1" fragment="single">GTPPPLSFGESDDNDNETGDQQSSPVTGAKSHRAKAVEAECPCFKESETQKGLTVVRRSQPSAEPPVYVHGRKLQHKRRKTIDNIVEGELQWPAQTRLAYVPVNKINKKNQLTTIQRILMQEIIDFTVDFSFTQAIYRADNCIFYQQKLAVDAARQLGYGEAASWLQENLHYAKVIIDVVCTVSSLCHLCYSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK44</accession>
    <name>A0A2R6NK44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001137">
        <property type="protein sequence ID" value="PSR72755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK44"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="191" mass="21163" checksum="5EDC5DDE7ED1CDA6" modified="2018-06-20" version="1">MTLNNNNISSEKNLAPRQPGDDRGSTSLGSSRPRTGKENFRSRIPVRILPTGKGKAKADPKGPAPPNVKPQPIVSLDSYPESPELLEKDRWFILDCRLLPPPPVPPTIEQNRRLDWAPKRFRTGYPSKFLGTPCPEQRAGGGTVKLADWVVFFGTKRLPTPPPGDVNPFSLPGSHEEDEHPVNQSTYNRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK52</accession>
    <name>A0A2R6NK52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK52"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="689" mass="77250" checksum="BB6B81D995CC00AD" modified="2018-06-20" version="1">MVQLFAFLVSIEEYADPQKQWPILTGADKDTSRTAAYLSKLEVPQENVLVLTGQRATREAIITKFQEHLIDNPKIKRGDPILFHFSGHGSRKPAPKGWKVIEDEEEEGEMRRKVEIIIPWDEGLEDDAGRKICGIPDRTIGALISKVAKLHGDNITVVLDCCHSGHGTRGGGDSAAKFFEEYAIRSVDPSGLTPLREDIDRDILAEDLSNPQSFRRGGFSESHGGNHVLIAACGQKESAVGTSNGGLFTTCWLDALRRDINPRTYAELTKHVEMKLDFVRSKNSRVTQHVQCEGVVRDRLVFEETMMSSELFPAERRKDLGENIVRIEAGEAQGIQQGTLFELHEMDNRLQSQRTMGSATATEVNAAHCIAEFGEGIVFDGSKCTALILQHRYLLKYSVDDTTQTSPAAKKTLALLRKSLSKTQPNVSSLAEEVPHGEAVDLVVEIDSSGEVVLDRRDPFLGTLKTDPPRIQPDEMETANFPYILNAIARFNMHLALTNPKHPLTDNIEFSFHRLEQYGKVEEWDDDDDPVLEPAETIPFVDDEARFVQRDDDRYAFILENKHPTPLYPYLVYFDPATYEIATWYTPFEAQKPTLLADRSLQIGASPEHQGSFQFFLPEDAELDTSFIKLIVLESMSKMDFMNQRPVLGMDEVGQSIVKKGAQHRAGGQGAQTKGRWDIIIKKLTVARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKD2</accession>
    <name>A0A2R6NKD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001132">
        <property type="protein sequence ID" value="PSR72845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKD2"/>
    <dbReference type="OrthoDB" id="2803586at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="89046" checksum="DF5D3EF2BA34C23D" modified="2018-06-20" version="1">MPEQVIVDNCCTVKGAILKSMPDCHISLDIFHCIARYTVVVLNGKKNPLIEAVAKDVSNALLKTRASGGNLAEYRDKYEAEAMLQMVFEKYSKIGGVWTAAAAKVSSMRHELDWIGLTYHGPHQVHADQLAHVKKGCLERRRQDIAADGSRIEGSHKAWNTLQRAHASGLEMFTALSRDFVHRRNIRIVLTTGHHRGPSTGFVSTTHGSHHTRLQNAINVVFNSLAERELSWGGNLFPLRPVLQQIDSGEAFGLVISDHSLTFGGLWQIKDEPDENQQLVDLITDPNEELDAAFVLRGIDIDPALLNQPQARVEPVPSGVPHLPLDPQSLALVLSRSSHASSSAVLQQCQSNTSASDIQVCSMGAVTTAGGLGGGKSEVPMVVDSKEQIQAVTIQDLTEDSPGVTVSPASESILVASTKRKQMAVDATAEHSSAKRSRIEIEPIASSSANRSQISDFFLNHRRPVAPISSIMPEVNKIIDNIQAKTVPSTNATALSSGQDKSGSSSHLRLLTLAAPLPPGPDIAGSELQGLSRSERLFAMHTGMHPHSLKISPSGTEFFVFMDIRFEQKWATYTMTSRKYITAADAYNIRLEKTNQDRGVAPTIKKTPRAIMDKLADIKAKCSQRILAGNYASKDSGDEAFWRKHCSIVPLGNESAKQKSGKPRKLQTCARCHKIKYTGGVGSEGNHRKLHCSDGVRTQDKLDAPPKWPQPEGIFTAGTHFHPLAFLEQLRRLYEKAVIQGDPSFDSMEAESFMEMLKARLETMELEKDGQMIKTVAFRVFPYLTMSPPLEDTVVMKDGKRYLRIDCLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKF3</accession>
    <name>A0A2R6NKF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v11232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKF3"/>
    <dbReference type="STRING" id="98765.A0A2R6NKF3"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR72865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="8388" checksum="E7FFB65047442752" modified="2018-06-20" version="1">MATSTTASQEELKAARVPLGWRDGCSALLLPLNVCRKEKYYLPWECENEKHAYENYIRRMKLLAKQKAAAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKY6</accession>
    <name>A0A2R6NKY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001116">
        <property type="protein sequence ID" value="PSR73049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKY6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="7023" checksum="6BF5D5F136CEE841" modified="2018-06-20" version="1">MKECSKGLKIWPCITVFMTTGTKLSDRTRANNTRLWFHRAYTRNAEKTSKSSRMKIKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLX0</accession>
    <name>A0A2R6NLX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001094">
        <property type="protein sequence ID" value="PSR73261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLX0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6632" checksum="F809A294FC4AA196" modified="2018-06-20" version="1">MAGNTGLRHGEVKNEIQERKERTKRIVMYSSPSQLLILSSSASLTVRAITAPPEEAFEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMB7</accession>
    <name>A0A2R6NMB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001070">
        <property type="protein sequence ID" value="PSR73526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMB7"/>
    <dbReference type="OrthoDB" id="2803471at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="121" mass="13290" checksum="B325589455066288" modified="2018-06-20" version="1">MADTSSNAELAAAFQADCPPASITGDVLQMVQYSVFAVFSALRVFAIWDRNVFMALLMLVLNLVPVATNTVSHSRVPFLSPSNPHFEQYVSTQETIMFTTDTTLGTFCGYIINVPTNTIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN72</accession>
    <name>A0A2R6NN72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001058">
        <property type="protein sequence ID" value="PSR73840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN72"/>
    <dbReference type="STRING" id="98765.A0A2R6NN72"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="82390" checksum="9CDAAB4CB0F6CBDD" modified="2018-06-20" version="1" fragment="single">REAVASEPNNAAFIGDLGASLFGRYQSTGQMEDFDQAVDCQRQALTLEPSQRFYWLNNLAGMHLKRYGMTGQIEDRGLVAHGQSEPSSGQTNQQDNLDKAIACFRECVDIAPSDRYRMVALVNLASAIHTRFERCGVLDDLEEATACHREAAQVGRLALGLNSTVLLGNFAAILTTRYKLFGRMEDLEESIKITRETLTLTPPNHIDHAMYLNNLGQYLISRYQQKKQLDDLKEAIRSLRSSLSLRTVGHDDYHTTLNLLASALYLQFTLLKQLADLEESITVYRETMTLGRTQSPNHWAAMYNLATALKSRYKTLHQVEDQEEVLELCQRAVAVFRPSHPRLSAALQSLALTCIDRGKLEQAFSLFKEAVNLPNSPLNDRLGCAREWAHTARNAGHSSALDAYVKSLELLDLCLASTPTMDLQHQLLAAADTSDDVPDISYLASNSASYAIQAGKLQMAVEMLEQGRALLWSRMRGYRHPLEKLRQVNPQLANDFKETGRLLAKLAVASDTDTTGDRGVQFDDQITRNRELSGRFEKIISDIRETEGFATFLQATPFDSLQRAAENGPVILVNVDRYRSDALILSSSGAPLLVSLSNNLPDAIDKLSSKLFKMDLSARSTDRYDATHQLSTGDMGTILRFLWVSICKPVSSALQSMEIPVGSRVWWCPIGKLGTLPLHASGRYEDGALLEGFSDLYISSYIPTLSSLIASRESATKPIAQLRLLGVGQSNALSSVEGEFKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN93</accession>
    <name>A0A2R6NN93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein prenyltransferase alpha subunit repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN93"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47688" checksum="054CC1C7739C38A9" modified="2018-06-20" version="1">MPTSLCSQIGSVLNGMLNSVEILPGDGSAWFGGEDELQTTTKQAFLFVDNNLGIPQKILYKAYLEASAIFNRGYRDFSRSEHPYDDSDSSVVKDMVYSSSVILATNPGHQTAWNARKRLVSSGMLDAQQELGFTTALLTIRDCAKHSVLWHHRRWLLRRIYPYHAEEHRTPSASTTTLRIPDLCADEDSLHNFDIPPTSLREEFSACSIACGTYDRNYFAWSHRYRCFNALVEAVAGTRPACSRLSDFHKITDEELAWCTQWVERHVSDYTAIQYRCNVVSMIAHSKFMIPRLETTTWPDAHSEPTPGLWDHAKSLVESYPEHESLWLYLRGALYFNTGVPEGEKQLLENDDVMAFAQRFLPESFSVTALRGATSLDLVCPSRPIIKEDFHNLAYRFILWFIRERMEYGKGRTRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNJ7</accession>
    <name>A0A2R6NNJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001037">
        <property type="protein sequence ID" value="PSR73980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNJ7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8483" checksum="1B20A7436E8E73EF" modified="2018-06-20" version="1">MNGKTADPAWPTPLIQPTLPINNHFGKMVLHWLTRMGYIGPSSKPMQDTATAFSSKEGTTQIVTSNLQSHTSKYSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNK5</accession>
    <name>A0A2R6NNK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v10195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNK5"/>
    <dbReference type="STRING" id="98765.A0A2R6NNK5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR74011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64690" checksum="22AD9834CCE854AC" modified="2018-06-20" version="1">MPSWPLVDSLVIAAVVILLIVSSGKGRRYWSSRYQLPPGPLGIPIFGNILQVSALRPYPQFLEWARQYGEIFHLRLGPQNVVVLNTAEAADELLVNRSKNFSSRTAPHIAQDIVSDGQRMVFLSYGKEWKIPRKSIQGAVGPGPSKRSRYIQDLESRTVLKDLLDYGDGHGRAAQFCEPTAKVPEDHWFSFFRRYATSNVMMVTYGKRAHKIHNNPRLHKIYDVVSNFVHVSQPGNFLADAFPILRTLPDCFASWRARAREMHAWEMELWGGFLDEHKKSVMKGDTSRDCFVSAYLRSREEGGHGEAPGLGITEDGWMRDKMLTYTAATILEAGSDTVSSAAQSFVLMMLNHPAVLAKAREEIDAVVGGGRLPNFEDQDHLPYIVACIKETLRRHSPIIMGIPHRSDQDEVYKDYLIPKESTVIGNMWAIHMDPVQYPNPAVFNPDRFYKAGSPTPWGSGPDMQDRDQCVMSPRSKHTHTNSILSAVQLSLFIVCARIVWSFDFEAPRDPVSGLPLLPDINDEEGTWSDGFISVPKTFPVVWKARSDSKAAMIEVLFEDLQSEWRSMGLEEDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP01</accession>
    <name>A0A2R6NP01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP01"/>
    <dbReference type="STRING" id="98765.A0A2R6NP01"/>
    <dbReference type="OrthoDB" id="3268356at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="13958" checksum="633AFF746A1C2A70" modified="2018-06-20" version="1">MSDLAEDPKVDELEEVPGDTDAAPATETPKRKRGRPPGSKNKKTAAAEAATAGSSAAAGASGEAPPKRGRGRPPKQRKPEDDAAEAEPQPKRKRGRPPKPKPAAPETSGDDGAEGEASEPVPKRKRGRPRKDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP14</accession>
    <name>A0A2R6NP14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP14"/>
    <dbReference type="STRING" id="98765.A0A2R6NP14"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="111" mass="12446" checksum="D49661672265A3A5" modified="2018-06-20" version="1">MRHAVTTPAYLFRKALDNILFALTAQQLPLESSAFKASQDPFPTRNPSGWLPLYTMVTFRPDISYTAVKRKVHQQSQILNYAAMARAPNVNESLDPVTRTNGYGFTNGDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPA2</accession>
    <name>A0A2R6NPA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPA2"/>
    <dbReference type="STRING" id="98765.A0A2R6NPA2"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26368" checksum="0141F1637A4FDE9B" modified="2018-06-20" version="1">MDEDGVEPIKPSLETCAIDGQLAIIAGSDTAATALAHLWYFLLSQPQCFNRLRKEVDDAFPPGEDSLMDLARQGAMPYLNACMLTTQGCIWDGRKNGWSTLGSLNSFVPDGTQVAAWAYSIHRDPKHFSPLPNAFWPDRWLSQEKFVLPSGEAISQDQVITERDVFLPFSLGPMVCAGKNVAMTEMRAVVCAVMQQFDIEIADRSCVDSWEDDVHEIFVTSRGTLPVLLKSRSLPTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQC6</accession>
    <name>A0A2R6NQC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000958">
        <property type="protein sequence ID" value="PSR74763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQC6"/>
    <dbReference type="OrthoDB" id="2692137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="694" mass="79494" checksum="259D922AD654AFDE" modified="2018-06-20" version="1">MVLRSSVDWLGLVARTFLPGTGIRWRDGLVGCATDDAKSVITSPNMPFIPKPEYGNIWVSIKADGRYGLADPTQWPQFMSEDSRWPWLCAIERKPTLTTNRVVMWAPFTPVDFVPLQGSLKMVMGDVKVLGTVHATRIEAMQLHVTEALQTVKLFEKYNARNRELTWLSTTMKDALDRLSFPATYRDMTRQHACVQRFWLMTNAWFEWHINIFQNYHLDRIDRMASLRVRDNLIGAFTTSPMFAKCLFDADIPVWFARTVDHLTMADVVLQPIDFEYPKMLTLEEGIFKDTRGFLGIAGNAHLTFLIHNCHHYADVEPTLLPSPGNFRATSSFPQAVISRATSTPFPGKPSSDRREEQSGSTATQLAVPGSVQSSKPGTKQPGHASISMSLREKFTDFQHPLMPPGCPIWVSALAKVDFSRPAPLGDNGWAFWLPEARLVIGSEMIDRQARYVMNWLRVRESWLYILTHHNMQDGVIGPLKAPQWREYLNTSARSQQEAFSKDTKKSLRKREVAAIFKRVFGVDDILEIQPPDEWFGRSLKNCTPEDLRLYYQQIAWELSELGFRYELLQLDYWLVPIDNEDPDRHLKENERRRLIAEVFPSDRDFVMGSLPIAVDGLAAIAVEARVPHLEALRQVLARWPDSPPYLKKARVSDYTSSVLRIEHIEMQMARFYCQCFYEIAGRAPALPRRFPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQD8</accession>
    <name>A0A2R6NQD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000957">
        <property type="protein sequence ID" value="PSR74779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQD8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10550" checksum="8884404D7C424B3F" modified="2018-06-20" version="1">MSERGKSCPPRVDKYLSGARICIDYEDTYLSGILSWSILRSMVSVYGSLQWSNGLGMADRYGTNGAPAESLYSSNAPQRAKGANSVAPLKGTDESHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQN0</accession>
    <name>A0A2R6NQN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000945">
        <property type="protein sequence ID" value="PSR74886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQN0"/>
    <dbReference type="STRING" id="98765.A0A2R6NQN0"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="83"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="514" mass="57109" checksum="B8A23B5ABB3E94EF" modified="2018-06-20" version="1">MLPQAEVLMTDIKKREEFMEISPDKGEDIEKWSRTSEPPTADINVHIIDVKEEARCDIFSASQCRSLSDSLSNRLVRRIDLRLLPASMFIYLLCFIDRSNIGNAKILNSDTGDSLAQTLRISDQQYLIALMIFFVAYIVFETPSNYMLKKFSPSRWLALLMLCWGVLTMALGTVHNFAQLAAVRFLLGAFEAGLFPGLIYCLTFWYKPEERALRVALISATPTLGGAFGGAIAFGVGQLNHVRGLEAWRWLFIILGAPSVACAIIVFFLFPDFPETSTWLSAGERELAIERIRGVASLGHARITWRETKETLTDWRLYLHYLIFVSISVPFSSISLFAPTIVSGLGFEGLQAQLFTVPPYAIAFVVTIVVAWIADRYEMRSWAALTTLTIAGVSYIAQGALPPESFKARYGLLCVAVPFSYASVPPLFSWLTANLRNTGASTLAVPLNVSIGSLGQIIGIFIFKSSEAPGYPTGLFTNAAFQIEGALFVLVLRAIYVRRNRQLASQTGVMKWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQR4</accession>
    <name>A0A2R6NQR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000954">
        <property type="protein sequence ID" value="PSR74853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQR4"/>
    <dbReference type="STRING" id="98765.A0A2R6NQR4"/>
    <dbReference type="OrthoDB" id="3267102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="541"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="747" mass="81142" checksum="62E927665B68BF66" modified="2018-06-20" version="1">MLVATPHLQGTHLLLSIRKLAADRQRRFSLDGVSTQAPFFVKPSPDAPESIELQEFINRQTQGSHLLSPDTPVARGHDVEHGQVTEFDHDEDRLRIPLNHSRPKNQRAPSPPHHNDAQPVFSEHGLAGLCGGSTPSCARSSFLDPRHFRATLTKMGLGLAQGLGALMNSRAEVGGAVMTDNPKDSQIILVDSATEAGVALAASWLDKPVLDAAWVYQANNQGVYLGADEDWGGNRVLENDADDGGVPLPATSAKYVFFVVTLSRFSSNIDIITRSPLLTPRRTHIEDQAPSYSLPSGRPPHSSRVPSSQTSYLSHTTSILPHAHSHSNPLLAQSHNIEDLAAIVQTLSSASALTVWQTILEVARRGGVQNPGRSSDTQAEHSQDPSRASSSSHIQGRSDEVSSSNAPSHKSYLRGIQATSHVSKSHNASASASSTSHLRQPSRHSRTPSPVSLSSSQSNGKRRELPIDRRHKRQKLSTPGIDTSSWDFSAPPPPLSSSTRRDRQIFKTNSGQPLVFVVQAGMRNGKELADTIKVDHLRPGIQNHGGKLGAEIPQADYIVLAPNMDYFKDLLTATVAAGKPAVQDAYVYECARQGTLLDEADFSFDGFEVRGQGFNVHLQGVSHRILKDHLAAGEDKTHGSMPLPAGKSPRRRASSGHRPSSSRLPTPPRNVVQFSAKRATRNRYTDEDRAYFSVYVARLLRGDPDMSASAIAEKLTQKVCFLSIELTLVCIHSRGICRCRTIAGHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRC5</accession>
    <name>A0A2R6NRC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Subtilisin-like protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v9234</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000910">
        <property type="protein sequence ID" value="PSR75268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRC5"/>
    <dbReference type="STRING" id="98765.A0A2R6NRC5"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015327424" description="Subtilisin-like protease" evidence="10">
        <location>
            <begin position="21"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="110"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="12">
        <location>
            <begin position="333"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="13">
        <location>
            <begin position="558"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR75268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="88038" checksum="DE19FD6FD691EE23" modified="2018-06-20" version="1">MKIFAWSFLLPAFLSVSALAAFPISSLRGAVSTPGNVVPNKFIIEVDSLSDIPTKRAIVSRDAHETLYVHMRKRNVGFGVDKEFNSPGLFVGAAVTLSGVDKLHAQGIAGSGIKIGIIDTGIDYTHPALGGGIGPGFKVIGGFDFVGDAYNGSNTPIPDSDPLDQCNGHGTHVGGIVGANPGNAFNISGVAYQASLTAYRIFGCTGDVTDDIIVEALLRGVSDGQDILTMSLGGADGWTESTSSVLSSRIASTGKIVTIAAGNDGAKGVFFTSSPGNAIDAISVASLDNTVIPLQNATVHGVVHDPITYFDTFPFPVTATLPIFPTSTDPTVVDDACNPLPDDTPDLSNFLVIVRRGTCTFVQKLTNVAAKGGNVSLIYDNGTGFTAIDVGNFTSTLIQTDDGVFLVNAFASGANVSLSFPQSGASAQFPDPSGGLISSFTSYGPTNDMFFKPAVAAPGGNILSTLPVPLGSFGVESGTSMATPFIAGVSALLFSVKGKSPEVGTTARTLLETTAQLISSSHTDGDPLQTVAQQGAGLVDAFKAIHTDIIVSPGEFLLNDTAHFVSLHTFTVKNTGAQVKSFKVTHIPAGTTLSLQPGTDFPADGPVPLSNISATVKFSETSFTVHPGQTQELTAHITAPTGLDPSILPIFSGFVQIANANESYHVTYLGVAASLKDAQVVDTTDTFFGFDLPALVDPIGDVFTGPANFTFNDTNFPELLMRLDFGTPLLLADLVDPNIKITTTLNRRNGLAFPQTSPGGTFSQIKTLGSLFEFDFMSRNSDQDDGTGFNLFNIASPLFANGTTIPNGSYKILLRALKMTGDPTKEEDFESWLSPILGIEVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRK1</accession>
    <name>A0A2R6NRK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000943">
        <property type="protein sequence ID" value="PSR74941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRK1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="6061" checksum="72BDB86764F0A21F" modified="2018-06-20" version="1">MKLLTRVIVPDSYPKRKRIDAMTSTSPVERAMLDIPPTHLWSSAPMPVALLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRZ2</accession>
    <name>A0A2R6NRZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NRZ2"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="443" mass="49122" checksum="38840B212EABD5E7" modified="2018-06-20" version="1">MSQFDRPPSNVLDLGCGSGLWILEAANQWPTTKFIGFDMLRIQPDWSECVLAFPDLMNNAGRIRWITGNLLEPLPFEPGTFDLVRATGIGLGVPEDEIIEDDLLFPGGISRPSSPAIYASMAQTQKENSPYNGHPKANSSFTSSFASHQTSKSSLSLLASSPPRISHMPSLLTPLPEAPTESSDVEYVDLAPLIGDPRPDFFKLLHPQDHSKLKTAWDKMLHKRFLPTGLLSILPFYLSTEFQEVQVKATLTVPLPPNNLPPLEEGKDTSSFLRARIDSISNRSIASVLSDMESMPSPINVSVQEYTSRQRSASVTTQSVSYASMHLARMVSIVRGCKEAMFEEYRALESPYGSDVDIVTARAEFSAAWSNWESDMKNRMCMRDNMQQHVSWISPSSGYPDWKLWRDRVAIAELHGADLNAADTSTEGGLCRSMTGFVVRKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS73</accession>
    <name>A0A2R6NS73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS73"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7157" checksum="FDE3E83AB3D06DFB" modified="2018-06-20" version="1">MQSSGRKQNIAVAATSSTSSGLVISQKPKNNSASSTWLNKGRTLKTHPMIVYSEPDLYTATGSLEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS79</accession>
    <name>A0A2R6NS79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v9004</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS79"/>
    <dbReference type="STRING" id="98765.A0A2R6NS79"/>
    <dbReference type="OrthoDB" id="2992663at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR75713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="25225" checksum="095AE0B4010DBA50" modified="2018-06-20" version="1">MDSVVGRDRLLTPEDEKNLPYIRAIIKEIERVHNSFWLGTPHMSTEDFNYRGTFIPKNTVVILNTVPLIPKSISAMSNIIQQWTMHNDPKRFPEPEKFNPDRYLDDHLTNAKSANLADPMQRDHWMSGAGSVVLYNLYTAFKGLTMFRRRRICSAIPLAEQEIFLAVAHMLWAFEMQQLPEEPIDLKEYDGLSGRFPVPFHIKMIPRDEHVAEVLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSB2</accession>
    <name>A0A2R6NSB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v8884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSB2"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF88">
        <property type="entry name" value="BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015354316" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="41"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR75767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="340" mass="37987" checksum="C506C80CC72574B1" modified="2018-06-20" version="1">MSLFLCLFSLALYSAGSLAAPSPSQNIILRDLAVPRFFGAAANTTFLFHDVNYTKVIETQFSIFTPENEMKWESIEPEPNGFDFTAADEIVRFAESVNAKVRGHNFMWGNQLPPWVNDTLSATELDRALKNHITTIMDHYRGKLYSWDVINEMISDNTPNETFKDNIWTQKFGEEAMPKALTYARAVDSQPKLYINDYSIEGINSKSDALYSVVSSFLADGVPVDAIGFQCHFTLGQIPDTLQENLQRFADLGLDVAITELDINLMGPSNATALEQQAKDYWTVVNACVQTKRCVSTSVWGVSDDHSWIPNGSVLPWNAEKQPKPAFYAIADAFEGKPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSB9</accession>
    <name>A0A2R6NSB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSB9"/>
    <dbReference type="STRING" id="98765.A0A2R6NSB9"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="50164" checksum="C0208145A0E9086D" modified="2018-06-20" version="1">MKQNGNIKVNAKYNPDERRHPPPANMIDSERDSELEKFIRAKYEFKSFMERPTKAVSSSSSSGPSVLSSSRQLDRSATVAALLGPSRSASSVSRVPNTRQATAPPEKTIPAVPTTTPSVPPQSSAPSGNTYSSSQSSSVVPSSQPGAARAPLQSASQPTTAFPMQATTMAPQTHAAPANPIWSGLQSLQPSQSVDATLPLQIMSTPTPSQPIPMSVNSSSQYVPATNPYSGLSVSPFSTIPSSFSQTGISPGTVGRSMSLNSGLSATPNYTNGLSPFQPSPINPSTPLPPISNTPSPNPFAQQMLQPVGNMGGAALGFSGTMTGISPQPQSSFGVPPPSFMSQPSYQQQQPGQMFQAQGQLQFSPASNPYMQAQTSGTSYMGMQYAGTPPPFTTQSLPQMQPMQQQQQQQYYQQQQQQQQQQQQQQQQQQQQQQQQQQQGFGGSNPFTSWIQQPPVQQSGYQNSWGGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSV6</accession>
    <name>A0A2R6NSV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSV6"/>
    <dbReference type="OrthoDB" id="2524554at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="488" mass="53029" checksum="A2F25CE4D393FFA5" modified="2018-06-20" version="1">MNPVQEQLSGYAGFTTDLFIRFLKYSAIGFVAVTLTTINAFECAHIWVENIELAAEKDEEVKKWQWDVESERWSGGSGGGTDPGLGFLGRHAVRAAWMAQNWGIGSEGSVMSSNAFSGRARSGVSGLNVVEARLEVAQSFLNIALKYAQERSASGQLRAQTIAELLARHANIMERMGQRDALYEARSEYERVWAGQPGKGIDAARTAVKLGDLSRRLGEYEDALSWWSRAMYLVKGSSGAAPAEILATVPDSVPTEPLAQRTFVSTLVSLSAFYATTGQLRKAKAVEESSLALLQSIPQSKTSESASPPESLHAFYILHRSALLSIHLAEVLYARSKKQTSSLEWLARAAESSERVALSLTGLPAIHPDAPESKIPHPPSTDAPLISVYAKSISLKRPAKSLLRDARRTAAEAWNLTGILTESHDTPGSKERALECYERALGWAGVAADRAGGIGRPGEGTLEDEWKALWSNYVRVREAVKNKASGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSX2</accession>
    <name>A0A2R6NSX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000864">
        <property type="protein sequence ID" value="PSR76078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSX2"/>
    <dbReference type="STRING" id="98765.A0A2R6NSX2"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="313" mass="34700" checksum="579A6EF4B1CDCFA9" modified="2018-06-20" version="1">MTLWASRAMQAGHSSSLRAHTKAMELLDQCLTSTPTIDLQHQFLIKNAASALASNAAVCAIEKEELEIVVQVLEQGRALLWSQMRGYRHSTEKLQELNPGPAEEFKRVCQQLEHLTVSSGTDLSGMKLIPISTTPYAAHGLNFDAKVTQNRQLSEDYKKIITEIRQLEGFSGFLRATPFSTLQSEGPVILVNVSKHRSDAVILRATETPLLVPLSQHLPAAIHHLSAQLLRVDEINQTEEQRDGPYLPKLVQLSTILEILWLKICEPIADALREMGQPKGSRVWWCPIGRLGALSLHAAGIYTLDMPGDFMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT50</accession>
    <name>A0A2R6NT50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v8601</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT50"/>
    <dbReference type="STRING" id="98765.A0A2R6NT50"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="119"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="235"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR76178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="329" mass="34855" checksum="A9B99A0EA5DFD177" modified="2018-06-20" version="1">MEAAPDALAGPDGPSVAVRAAKDISFGSIAGMTAKVFEHPFDLTKVRLQSQVLDSTARFSGPLDCLTQTWKKEGVRGLYRGLPAPIVGAMAENASLFLSYNEFQNVIRSYTGQPLSQELSLGQLAIAAAGAGAVTSFFLTPIELVKCKMQVQMLMSPELSIPGASSTAFQKLPGPISVLNNIVRTSGFKGLWLGHTGTLIRETGGGVAWFISKEAVARFLLSRHPPAEDGSKRHLAAWESAVSGACAGVAYNFALFPADTVKSTVQTEAEMRPRAPGEPYPSFLGTAKAMYKAQGLRGLYAGCGITVARAVPSSALIFLIYDGLNRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT97</accession>
    <name>A0A2R6NT97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000853">
        <property type="protein sequence ID" value="PSR76257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT97"/>
    <dbReference type="STRING" id="98765.A0A2R6NT97"/>
    <dbReference type="OrthoDB" id="3258400at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="373" mass="41847" checksum="AB99148D7787878E" modified="2018-06-20" version="1">MDSNYYPSFTQPHHHDASSYGAHSYPSPLSPYPQPGQHQYLFQPDYSLCDPISFNSPELYLPPYEVQEQSQQPRAYEVHSNLSPLIHAPIPISAYSTLLPSIEQSQPLVHSQTKQDCFTSAESVVPAFVACEAQEHYGPLDCYVDAPQATFPTPCELLNELAARDRAAHLFPSDPGASSSMSSADEHLAKSKPKKTWKSRPVTNGKPENQRKAYFRSVAENVGFKPTDPDTITSHDKKRHYLECLEQYVLYLHEQIRLVGSGPSQFNRVVDYRGLNSRSIRNESRRLHLEVREEERTYTELLKSQTFFHSQGAADIRNTGQPAVHDLRRNSIASGMIPRCAALHTAIPPQPHCVNGQMDITTLNLDTGIAIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTI3</accession>
    <name>A0A2R6NTI3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000847">
        <property type="protein sequence ID" value="PSR76383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTI3"/>
    <dbReference type="STRING" id="98765.A0A2R6NTI3"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="61"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="285" mass="30604" checksum="4AFE17D07FE58C30" modified="2018-06-20" version="1">MSTGTIVVSALLPLFLNRLRRKSTFERGALFCSTKFSPPSSTTTAAPPPKPTSTGTTIKRGISYNQAQLTENFSGSKVSWAYNWASAPGGELPKDLEFVPMLWGGGDNSNWVNDATAAIASGSTHLLGMNEPDLGAQSNLSPAAAAALWKQFMEPFAGKAKLCSPAITNGAAPMGEAWLDDFLSACDGCTIDCIAFHIYDSATNVAYFKNYITDMGTKYGKPTWMTEFGASGSTQDQQTFLNEMLPFLDNLTTVERYAYFMAGQDILVDNSGNLLPLGQTYNTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTQ9</accession>
    <name>A0A2R6NTQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTQ9"/>
    <dbReference type="STRING" id="98765.A0A2R6NTQ9"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="23629" checksum="870CA335295E5E6E" modified="2018-06-20" version="1">MASVMGFNSGVNPVDMPRYEAVAYPGEIVSEGMTIMHRHFGRQHNGGITLLPYINAKVDNQLSFSPHKMARFINFLYLVAVVSVASALTVSDKRATGGYVQNPSGTASFTMYSGCGSPGISILSRAKYLLLKDVTSACGRSATGFTAAISQLAFGSAPGSGAGDACGRCFSITGNKDPYSPNFTGPFGKSIVVKVTDLCPAQGNEEWCGQSQSSPLNQHQEPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTW1</accession>
    <name>A0A2R6NTW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTW1"/>
    <dbReference type="STRING" id="98765.A0A2R6NTW1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55837" checksum="090703C14917A630" modified="2018-06-20" version="1">MVDPIIESERDSTVKDICVIGTGPSGLGALKIIADSPQYKAGLWRPVAFEAREEIGGVWVPAPPTDNPPLTPLYDSLTTNLPHPLMAYPSFPFPPSTLLYPPASTVLKYLQSYASHFDINQHIRVNTSVRSVDWDKELSRWRVRTSPTSSGADAPTGESLFDLVVVANGHYRVPRYPDIPGLDAWLAIGKTSHAAWYRHARDIGDTILVVGGGPSGLDIADEMLAVSRTVVHSIPGTKRADRGSLKLRGRITEFADVTEGRVVFEDGTSESGIDHCILATGYEHSLPFLPGTLLQQSLPPPIPPIPETLYNSTYHIFPLAKQMFPLVTSFPTSSLAFVVLQYRIIPFALVETQMRAVLKAFAVPESIDPANEAVDIVSRYEELRKQVGDDERVIARAWHKLEGEEQFQYQDELHKYVGGEYAGPEWKVPDWYREVWEYKFKLRDEWKELVRIGEAERWVQGVGEAGGAEGTKEWLELMRRVIRRAEDRQAAPSSQRGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUK2</accession>
    <name>A0A2R6NUK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000823">
        <property type="protein sequence ID" value="PSR76949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUK2"/>
    <dbReference type="STRING" id="98765.A0A2R6NUK2"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="493" mass="55753" checksum="306A5E8F84D7A657" modified="2018-06-20" version="1">MISNRAAHIVKYPRIPSSVLLKYRSYSENATEPDHRASSQLFQDAANEEAELAEKAARSSRLAAMETKHENWTGEETMQDAVLRMLVDKYKPLRSGPVRTAEEKLKQNPPKIGTQIPVKDTSVNTDAFVELTTEVRTTWGASTSRSMAEVPLLPSIEGHQPWHTTFRVPSHAQSSIKYGHIPPSSTSRPLPASALDDKARRKEREAKKRTEHAGRIHNAKESTLDYRLGIKGSKHGASVAGRRPVPVNLKGWATLVEDRIERARQEGRFDSLKGRGKPLEQFVEERNPFIAREEFLLNRIVQRNGAAPPWVELQGGQPHSQCSHTASHFLKRIIIELETAINTLRDIMRQSWIRRAIRMLTLSRPAALLPKLTLEDVMSLRDPEWEIRERAYHDIALEEVNSLVRKHNGLAPYAVRRPHYMLSVELEKVYRESGEDILKGIAERVNPRAGSLGREQGLNWDEEETSAVGGSTSLAPLRIRDVVRQWIGKLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVM7</accession>
    <name>A0A2R6NVM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVM7"/>
    <dbReference type="OrthoDB" id="3366352at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46241" checksum="F78F3AA8DC33EDF0" modified="2018-06-20" version="1">MSQERQDNCLLSSSQPAIRLPDDLLELDESSQSSGRSLSVSINATTVDDPVQAPRRAMHYFVPRPFPPPALANVPVEYIIDQLHTLAPHYWSKPETADCTIIVPIDGLFRKTGQASRSSGSTPQPFPVPMSSQHGSSTTARRVTEPTLRPSPRMVMKLHVDYLSAHSTLLRGLFSGASPLDLIQSSSHSSQSTPRGSFYNLSLHSNSPPPFPLPSTARGLPIAPLLPRLLPSSPSNPTIYLPVPDPDSFRLLIHYVYFGSTTYIEEALDTGDVTWEGLARNVEFLGMGTEIKVCLGRWYGRWRRGRAAEHAAFQTEEYDEYDDDSYSDSDEDSFFDSDDDEADGSSCTSAAMDESDDDMEIDECLKRTKLDSYSRGRQRTIRRLGHAISDPGPIRGRHSRPTCYISQSSSPSSRGIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX83</accession>
    <name>A0A2R6NX83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX83"/>
    <dbReference type="OrthoDB" id="3355886at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="204" mass="21857" checksum="A0CFF977E60BCF34" modified="2018-06-20" version="1">MSSALRSVTKHTRSVSRTIAAAPTRSFHSPFAVLSSSPLTSPPAPSSEVSPLYEKQLDHSPHPQLSPSGQRTYVVSEPDPRSTPYEVPYGAYPTSAPYQNFPATEAPTIEPRASTSPNLAHPSTTRAVPQNPEGVQESSAVRFREAPGKLYEKGGSYGGLGLMDEASTKPGEGELSSRNPQPDQPDVAKKFSDLGVDNAWKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXW8</accession>
    <name>A0A2R6NXW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXW8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26642" checksum="30E4531B35417C27" modified="2018-06-20" version="1">MRRASSSSSDIAGSTDNPFQEKWLLLVDEMKEEWAKVGGISMGIVEVVITVATLQFHAGARSPMLFTFGALTTVCGLIGTVLSFYHTIHAYVLSNLNIEKVRAEVDTSLNRPYLLALPVLCACPRAFFIWTLIFFACSIASLAWSLTLDLKPSSDAKTPGPNQDPPPLPLVVPIAVSIISIVLTAFATLDIVRFGSLVDAQPYQPEEPPRELLNMSPLSTPRPRLAPLRTEDLKAGYSRGGPMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P032</accession>
    <name>A0A2R6P032_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR81996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P032"/>
    <dbReference type="STRING" id="98765.A0A2R6P032"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR81996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8307" checksum="C333268D6D75246A" modified="2018-06-20" version="1">MAQEVKLEYNAKGMPFRRLGNTGLRVPIFSLGGWLTLGRTVKGDSATDIIKVAFENGINMIDTAELYAKGESEIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P055</accession>
    <name>A0A2R6P055_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v6199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000602">
        <property type="protein sequence ID" value="PSR81959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P055"/>
    <dbReference type="STRING" id="98765.A0A2R6P055"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="133"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR81959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="257" mass="29475" checksum="E2CF30B3C2894350" modified="2018-06-20" version="1">MGPAADFLEKLGWISRPPSDSRFSHPCNVRCQTITAKLLSLRADQCLGINCDVEVTRKVAVVLEELGLTYETIYLDFKSGEQKASDFTKYNPNGRIPVLIDHKNNDFVLWESDAILLYLVGKYDPEHKVSVTADEQKYQIIQWLFFQASGQGPYFGQAFWFRFQHSEKIPSAIERYQKETIRVLGVLESVLSKDEWLVGGKCTIADLSFIQWNDIVDRALEGYENFNFEKDFPAVFAWHAKMKARDAFKTIAAVWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P069</accession>
    <name>A0A2R6P069_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR82020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P069"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6206" checksum="020DEA6EA1B6BB0C" modified="2018-06-20" version="1">MRTHGPLVRLAVNPSFSNLEIATTQITTETANAAPDVRNDSKERKENKGKGYQWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P079</accession>
    <name>A0A2R6P079_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000600">
        <property type="protein sequence ID" value="PSR82058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P079"/>
    <dbReference type="STRING" id="98765.A0A2R6P079"/>
    <dbReference type="OrthoDB" id="3268967at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="124" mass="14311" checksum="84BBF59162D5CF3D" modified="2018-06-20" version="1">MRWDGPYNVVQAWPNSSVYTLDLPEHSNAFPTFHSSLLKPYIHNDDECYPSRAREVEPPPVLDPDTGEKHQFVERILDRGRGWQYLVRWVGSGPEHDLWLPGSQVDDLKALDVFLQEHNLDSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P085</accession>
    <name>A0A2R6P085_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR82015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P085"/>
    <dbReference type="OrthoDB" id="3224744at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="824" mass="93613" checksum="3282A5D775D0E4C9" modified="2018-06-20" version="1">MTLRLQIKVHRLSNPDGKSDFRSEISFSKGQHGVCEINSLKDELSTASSPEAGEIDFKTAASAVRNHEIPDDLDDLTLEELAQLPDGHNNPAITALQSLVRGLLISETVTLRQQFSVSLPTLGVTTLIPDCSPASEDQEGCHTVALEIIVLRELSLLGLGPLLKELGDIFIHQPESDSELPILFYWLAFQVNHNPETHDILSRLLVNRLFSRGLAIDPSGRLVDPEELCTMIYMTRTAVERWGREHGDILGFLTERLVLLIGKFGCTLTLENGVRWCQEAFALYPTTDHAEVEIFGRLLFTRFQRLKREEDLEEALVWGRRALDVCPADNEQARVHDLYALGERLFAKHRTFGNVGDSDLDETIQMWRAAYELESNGKGGSGCPAFVSLHQLATATHARYIERRQQADINECIKLGRRLLEFFPPGHKHRDEAISMLCEFLVEHIHDPKYMEEIVDLLHQKQYPRDHADVEPHCRSLCKSAGIMMYCGYLSSKVEYVDEAIRLFQQAFSITVTNEGKCGASTGLGYAHLVRLWAKRSASDATAALEHLTKAYNEWDSHTALMGLVEFYADEENQHYDPQRAIGLLETCLEREDMGAGQRLEFVTRIITSYPDIAIDTKFSKQLQVILLKTIRLMPRAAYFGLHVKSRLRTLRQWPSWVNLLATLLCSNHKPVQAIEMLEEARAVFWSQGQQLRMDFEQHPSPPPSYPEKYHNVHHRVPQLPQEFRQRLYRIAQELESASFAPELGMTGIMPMIEDEELVRRRRLNAEYNDVIEQVRKLPGFECFMLPEPICLLAEAAAKGPVVILVSFGEAYAIIIEYPDTHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P173</accession>
    <name>A0A2R6P173_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P173"/>
    <dbReference type="STRING" id="98765.A0A2R6P173"/>
    <dbReference type="OrthoDB" id="3062801at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="252" mass="28203" checksum="047433118B4189E4" modified="2018-06-20" version="1">MFQIQDAAGDPLTRWAALFSLIFAIMSLTYGCIYIVQFGSMRSMYKASRWAEEGQKTKTAIWWNIWVLLAMPAIWLAWSMTAFCVAILSYVWRTGSSSDPSDGIRAPLSPEQAVIVRTILTVIFGIGLIYFILILRTFSSYGEREAGWRRSWLATGHPTLEERARRDAAERARGRSRDRELNRDRTEREAAPDRGSDEKPSPVMGLGLSGMSASPSGLASMSGVLREEANLDPGDGKRREEYTGRGRISPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1S4</accession>
    <name>A0A2R6P1S4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v5659</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000555">
        <property type="protein sequence ID" value="PSR83652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6P1S4"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1017"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1126"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="657"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR83652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1289" mass="143767" checksum="879164CAE0462A15" modified="2018-06-20" version="1">MANQRHEFHAVEGEVHYHSFSPEQIDKYYRGDVQYCPEDDVHFPTLTVEQTISFAAKTRTPQHRVDERTRAEYNATMTDIVTTVFGLRHVRGTLVGDAAIRGVSGGEKKRVSISEALATRSLINSWDNSTRGLDASTALEFVQALRIATDIGRMSTIVSIYQAGESLYDLFDKVCVIYEGKMAYFGPANRARQYFIDMGFEPANRQTTADFLVAVTDSNGRIVRSGFESRAPRTAIEFAEYYNRSEIADLNRQDIASYEAEFVGKPELMDAYKSSARSEHAKTAHPKSPYIISIPMQIRALMIRRAQILKGGIIAQVIQVAVFVIQAIIMGTVFLKVPDSTSAFFSRGGVLFFALLFAALTAQAEIPALFSQRPIVLRQSRAALYHPFIESLALTLVDIPISFITLITFSIILYFLVRLQQSAAQFFIFFLMVLTMTITMKAWFRTLAAAFKSPAPAQSVAGLAILVLVLYTGYAIPQPSMIGALRWITYINPLRYGFEAMVVNEFHTLDGQCATLVPSGPGYEGVSISNQVCTAVGSVPGQATVNGNQYIALSYGYSYGHLWRNFGILCAFGIGFVSTYLFFTEMNTSSSAASSVTLFKRGSNAPVVKAAEDETRSDEEKNNNEKGAGGATREGSMVDNKQVLAETPAMKDIFSWHHLEYTVPVSGGTRRLLNDVSGYVAPGKLTALMGESGAGKTTLLNVLAQRTSSGVVTGDRFVNGQLLPADFQAQTGYCQQMDTHLPTNTVREALLFSARMRQSKSIPDAQKEAYVEQCLKMCGLEAYGDAIVGSLGVEHRKRTTIGVELAAKPRLLLFLDEPTSGLDSQSAWAIMSFLRDLADNGLSILCTIHQPSAELFQVFDRLLLLRKGGQTVYHGNIGHNSSQLISYFERNGAAQCGELENPAEYILTAIGAGATANSTTDWHDTWQRSNEAAQLEKEIQEIYTEGRNRPPVETNLQHEFSTPWLYQVSQLFKRDCQAHWRDPTYLLAKILLNIVAGLFIGFTFFKAKDSMQGTQNKLFAIFMSTIVSVPLANQLQVPFISMRDIYEIRERPSRMYSWSALITAQILAEVPWNMLGSSLYFLCWFWTVGFPSDRGGYTYLMFAIINPMYYTTIGQAVAAMSPNTEIAALLFSFLFSFVITFNGVLQPFRQLGWWQWMYRLSPYTYLIEGLLGQAIGKRDITCSSVELVQLDPPSGQTCSQYLTPYMNAAGGYITNPDATSGCEFCSFRTTDQFLSASFNIEYSHHWRNFGFMFAFIAFNVSAIYFLTWFFRIRTESLIGWIKRRVARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1U7</accession>
    <name>A0A2R6P1U7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v5632</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000552">
        <property type="protein sequence ID" value="PSR83733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1U7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1U7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015317754" description="Cytochrome P450" evidence="15">
        <location>
            <begin position="21"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR83733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58871" checksum="6EA5695F452AD58E" modified="2018-06-20" version="1">MDWILFSILASAAYYLWTRSAPSNEPRVPPGPKPLPVVGNILDLTAKELWLRMTNWGRKYGDVVYIHVFGQGLVFCNTYDTATDLLEKRGAIYSDKPALVMAGELCGCENMVAFTRYGDKSRRQRKLMNSALGINAVRSYRPLLEIESLSLLKRILADPQDYLGYVRRYAGGLTLQSIYGYRVNSNDDVFLTLANECVDLLSNRIASGGGIWPVDIFPSLQHLPLWFPGAGFKRKAIQWRAKMEEFVDRPYQLVKERMKDGTAVPCFVTTLLDDPRDEKSQKPLDAQRDFDIRWTANSMYSASIDTTITVVQHFLLAMITHPQVLKKAQDEMDRVVGNGRLPTFDDRTALPYLECVMSEVLRWGVPVPMGLPHRLMEDDVYNGMFIAKGTLVFANIWNMLRNDELYPNPDAFIPERYEAETDDATKKRKDPRQYVFGFGRRRCPGVHLIEDSLWIVMATMMATLDITKPIDENGRVIQPNVSFDNSVFRTPSEFKCDIRPRSEHALRVVRQATEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P208</accession>
    <name>A0A2R6P208_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P208"/>
    <dbReference type="STRING" id="98765.A0A2R6P208"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prospore membrane adapter protein SPO71 PH" evidence="3">
        <location>
            <begin position="300"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Mug56/Spo71 PH" evidence="2">
        <location>
            <begin position="635"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR83892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="797" mass="89405" checksum="5A07966AFEC92507" modified="2018-06-20" version="1">MPESVISNMEGHQRTKGNTWIPFLQRQPTSSSDEEVGVRNAIREHALQFFLGHGGRKEDWGESQEKGVREEMYRRWKESEWGQARARRRELKSSSVWVGSSFDVGVFLGVDLLIPSPSVQRTLEADSAMFASPSHVAVTGPTAAETFVTAPAFPNEGTSAFRHLPLQPPVLPRLLVPSSNDNLGRPVSTDSSTPLLPTPAVTIDAHSTNGRSVPHDQGCGISSSSVSAASDVNGTQGLIPPVHSSKGKAKMVHYSDEPMPHEELASPSEVLARTGSAVQDTSAGAALQATAENQVKWGDVIMRDRMLVQVSFSNLETVGANFDETKNRVTPHMQYDNWKELIVVWRKDRLEIYKDHGNAPSHLELRLQEHRATRLTLKDGTRLDEPPSIEGYADRIRPSSQLKQALYLSTHNGYLFFINAIQAHPPPPPGPSIGVNDSQALNTSETIRGARQVLEATGMTDLRNVVAVRRAFQVIPSQSEGVAAHDVPEWEDGESFWENVDTYDDDYRDGGGEEGLANVQDKQQRQVRRSFELLLKSGRIMRFEVYSCQYALEWIARLRPLISYWKKRHQVDAREEMDLVHASTGRPRITARRHVHDEQDAAPETPPDPDKSSPDLSSFYNWCLLDGCRAISKCGKLFSRKGLRGQYKHVQLVLVPGHLVQFRITGTSLYHRRGKVIHLLDSYVCSGYFAAQYLPEGQYDPDSPPLPRRYQDGLESNDQDEDTLFMLWSYKKERDALNVSSKNIPPLSAKRQIFVFRTRSKLERDAWVWAIKAEVEKAARDVPAREKSLREDGELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5F6</accession>
    <name>A0A2R6P5F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5F6"/>
    <dbReference type="STRING" id="98765.A0A2R6P5F6"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="204" mass="23405" checksum="ACA792DAF74B6659" modified="2018-06-20" version="1">MIIMRNMDELMEMDLPRDWIAAAHACTCNPRKLPHYPKDWIPANCPHTSVQHPGGLTSPPRITESSPRTYTLLNSGTVVLHPSKELAESVIHYLSTSPLVPTFSFPDQDLLAAHFAGRWKVLPWCYNALKTLREIHKPLWRDDEVRCLHYILHDKPWSTPRGTAGIYELQNGWWWDTYDKLGQEMQASNPEGWAIVDAQVTKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC59</accession>
    <name>A0A2R6PC59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC59"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5879" checksum="3693948B723AEB12" modified="2018-06-20" version="1">MRRMSYGAYGEERRVTWWLVTKMCDGDNLNRKVTMIFESEVYSADGLAAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG96</accession>
    <name>A0A2R6PG96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG96"/>
    <dbReference type="STRING" id="98765.A0A2R6PG96"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="587"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="945"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="961"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="983"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1082"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1110"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR90834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1124" mass="125378" checksum="9DF6C7834FDA3366" modified="2018-06-20" version="1">MPARTVFSLDDLSTSVPKIFQQVQLTTANHQKNYIALYKLQTDAAKQRENVQNGRSVKLTGERAFEDVFISMLSRALPVKKGATVADRILKFVGGYTKLINEKAAEDRRKPGYDEDDDDTASRFVNRLLRFLFKGCTAKDKVIRFRVVQCIAEMVAHLGEIDEDGYTILRDSLLERVRDKEVPVRVQAVTALSKLCGSEDPSEQPNITDILLDTLHHDASADVRKAALVNLPPSPLTLAALLSRSRDVDPTIRKLVYSAVLEPNCVINKPSSEGQEQTVEGVGLTHPRVLSIAQRELIVRNGLGDREESVKAAAAKLMSTWVDVVRPAEVKPEEGQGVAEADLIAFLNLFDLVENSTAENALVSVFKTRVDLLDGLQFGDAFWNSVSPEKAFLARVFVDHCVSTKDDARLENALPVVTALAFKIQATYNELLEQVQAEEEEMLLRGAVEEEHEEERIEREFVIGEMLRMAVNLDYADEIGRRKMFQLVRDMISQDILPEGLVSRCLDVMRELSPSERDLIRVVVEVVHELRDPSDEDEPVRDTSGADDAETTIGETPMTARTVRVGPKPATEMSPEERARADAIDLRCLSLCIGMLERVNGTFEENSTLEGILGELIIPAVKRKELLLREKGLVSLGLCCLIARRMAQNSFQLFLSQLQSAPEVLKIRVLQIVFDIMMVHDGIFLGPGSTNGERIVEFLLHILDTDESEKVQALLCVGLSKLMLSGMVADERVLQSLVLIYISPETVNNQELRQCLSYFFPVYCYSSSTNQRRMQKIFIPLYDKLSEVYKEWDGDENMISPAQASLMFVDWTDPQKSAAVAAKVPGHVVDESIHVDLASNIIKALFNDELEKDDKKALCQLLGRLYLPDKVDDDKIRTLKFLMDNLSSRRPLRDSAAKNAFAKFETAISKKFDAQLADFNEEEYRQLEYLQELFEFVDDIIPNDAEEEEAPKRRGGKKRSVSVVSDMTSTTSAPSGDESTPPPRRKSNGKGKAKRRRLSQSDDESDEETPTERGGTPLSVAPTRVMPRRSAADKSRVAVTKTLAPPPSETEEEDEGGEDEEDEEDDEATPAPSKGRGQGDATKVREAAKSHTEIDDLSDGEIQHDSIMDSSEEEDADEVDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNA4</accession>
    <name>A0A2R6PNA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNA4"/>
    <dbReference type="STRING" id="98765.A0A2R6PNA4"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR94077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="364" mass="41816" checksum="5726AE3F45208442" modified="2018-06-20" version="1">MSDFEQEREANIARNRALLAELDVSLVIPKKEPPIKKDKAKPVQPVKRVKREPVTPAPVRQSARLKRSAPDPAESPAKRRKREQDDEKIRRQQEQERLETEERAREAKKPRHQNLKLTELLEDTDAEDSTLLTAAFQDTMEERGVGSQTEFVFDEEQQEREVSELKKKLKGMKVIARAKVTQDRVYSAAYHPDRTKDLIFFGDKHGQLGIWDARAPSDEADNGDDEESSKRDDAESGKYWRLQLHWPATSKSSISTIKFDPIDSHSVSSSFALRAKGEISKQRPYRYSQVRTIAQFAVYPSLPECPEKYTPTRTLSYLRSTFHPTEMRCGYQTLPEGSRTSICEKTNRKRDGISSLNRRSEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNP7</accession>
    <name>A0A2R6PNP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNP7"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015306079" evidence="1">
        <location>
            <begin position="17"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="166" mass="17649" checksum="B711DACD86A57837" modified="2018-06-20" version="1">MQSFFVLVCFVAACLGQSINIAAPLINSTVSAGQNITVEIDRPVCIGIPVVRCSGTDSVLELQRTLSASEEVALVLSMVSCSPSCTDPSYDPSSSLGDILYNGLFDPEDHPVTPPDHKPPYQNFTVQVPTSFTSGEEIALIATHFTLVGAGPQPIVEVKFLPLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVA3</accession>
    <name>A0A2R6PVA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000442">
        <property type="protein sequence ID" value="PSR97187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVA3"/>
    <dbReference type="STRING" id="98765.A0A2R6PVA3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="365"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="732"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="804"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR97187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="977" mass="104290" checksum="E149BCD66AD62119" modified="2018-06-20" version="1">MDNNHHGFVRHLLDHPQVRQQIGEAVHALFGGLLNHNHRQSADEVDTDMPSTPAASTQDPPPYEAVDRETAPVEGPLPASLITSTSSVPAEANMSHVAYNYESDDSMPSLGTVSESTDNEDTFDVEMSENQIFLPHPLSSGSTSGDEPMSRPPSSIRNSRRARVEEDEDEDVMRETNRQRMHPPVPEDAHDHHFHPDIHDHAQHHAQQQQPPNGHPPLLSRVTYVVDILPPAAIPPPTATATAAGQRPQPTGARGAPPIFYPFGPAGFHFHAAPGGAPANAEGGTNVPDTDGQHAGTNFEHDFNIFVQGLRQMNAMPWAGFFNNFEEQEDPERAKKLLTGLEEVPEGLVKRMEIVGSDEGEKPVCAVCFDGLLDPEAGTFGEENKEEEADYHDGDPTHAGGSAPMEVEAEPTTNSSAPSPTTSDEQAKFVESVKHKVIVLPCSHVFHASCLLPWFTRPHRTTCPTCRFDIDPDSLTLSVPVGNRRARPRPPHQAPAEPGAGQPIPAADGTGATHPNPVHTPFGGDMPLPIPPPQAGHGPRPHVHGRGTSFRIGEMPFGFIVDVNIFPGHVPPQQQQGQGAVPGHIHLPRFGPPPQRTPAQPANPANADANAPGASARPRPFNPGMAGLGPVPVPVGMFAGPALFEQFLFGPQPPPPSGPAHADTEPVDPARTAAAEPQPPQPQPRPPTATANAGATLADLLGLGRFEPQLGAGAQAQEPLPSFEEFVNLVGQPAPPMAQAPPPDQPPATEGAHPQPQPPPLRQWQGFFPGGQAGSPEAEAQMNVMLDDIATSLFQQMFPGIGGARRPTGAAGAQGATDAPPVPPGPIPFNIPPHPRQRPSPQTPSEKRQWAPPPPPGPTLRERVEKKEREMGLRCSDISCGLGPSDEDPRPVVDPREMRQVHIHPLQGQGEGKESVCDHMFHPACLVSAERVAGWSGADQKKEVEGDEEEVQVSCPACRAVGCISRIDWDEGACALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVH4</accession>
    <name>A0A2R6PVH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000444">
        <property type="protein sequence ID" value="PSR97180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVH4"/>
    <dbReference type="STRING" id="98765.A0A2R6PVH4"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="8963" checksum="1FC6BC9A51215180" modified="2018-06-20" version="1">MVPPDKLHSNGTRRTHQHTRRLLDAFDLNTLWDDYGVVGDLIVIKGTFKDHLVAWIGEYLELVHGAARAAAIMANIDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2C4</accession>
    <name>A0A2R6Q2C4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000403">
        <property type="protein sequence ID" value="PSS01015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2C4"/>
    <dbReference type="STRING" id="98765.A0A2R6Q2C4"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS01015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45393" checksum="E9FEB0C4769003FB" modified="2018-06-20" version="1">MSKISMVRVVREGKEHLYIKSLHDRYGDVVRIGVHGSPLYITKGLASRCPGKQISSSIAIHEYRPVIAKRVRQLVDKLSSPKGNTVDLAQWMGFFAASVIFEHLPWLQHLTVPGIGRGLKRLHEVAVGGTEARLERETSKRDFFRHLNNKDSATSEDIPDGVSAWIVESHTTSSVLSNLFYCLLRHPHAYARLRAEVDECYPPLTDESESDVDIEDGLDAEKYEEMPWLDAVIYLPEGNQARVHTYSIQRDPRNFSHPETFWPDRWLIASNSPSPLSSPNPSSNLSSKTNKAAAFTHNNDAFLPFFSLDPADCVERDSAIQTMRVLVCYFVKRLDVRFAVGWDPLDWEKERDEGERGEKVGRLPVVVQERVRSPHSPYRDPAPYLFSLNSTSSTSTAIIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5E0</accession>
    <name>A0A2R6Q5E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000399">
        <property type="protein sequence ID" value="PSS02208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5E0"/>
    <dbReference type="OrthoDB" id="6511194at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="175" mass="20409" checksum="980524E8B8639643" modified="2018-06-20" version="1">MAQKSHLQEFIESRGHICDFYPNFHPECNYIEQYWGFSKYQYRLSPQTSNIAEMEENVRASLDKASLLQIRRWANRSGRYISAYALGLDGAEATGGARDKSQRARDEKRERERERQERERFQEPPDDIQTYLGATNSVHRAHTSLTDNIRATEPPYKPPDDIQTTDHTTDNTRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5F8</accession>
    <name>A0A2R6Q5F8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000399">
        <property type="protein sequence ID" value="PSS02215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5F8"/>
    <dbReference type="STRING" id="98765.A0A2R6Q5F8"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF29">
        <property type="entry name" value="PEPTIDASE A2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS02215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="26003" checksum="913F907D70C28F30" modified="2018-06-20" version="1">MLRQHIGSICHVYLDDIVIWSQSLEEHRQNVTTILECLRKHSLFCSPKKNLFCLAINFLGHHISACGVKADNAKVEKILDWPVSHLAMEVCFFLGLVQYISNFLPSLAAHTTMLNILTAKGADKDFVWTPSHFAALEAIKSLVSSQECLTVINHNNLGDNIILCLVMLATFVLGWFLPMGLLWSHPSWLLLNCNNCLVQSSTTLLMKKNCLRLYVRCVNGELACLVYPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB86</accession>
    <name>A0A2R6QB86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB86"/>
    <dbReference type="STRING" id="98765.A0A2R6QB86"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="859"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS05374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="953" mass="101272" checksum="248F8E6BA93B3F7F" modified="2018-06-20" version="1">MRNGSERGKYRPCTGVSAQNAPTLLPVPPLQWINLTPLIQGANAAQPLKDASIGYDDNGRNLLIFGGESSAGFAQSSTYLLNLDSLSWQTINAPTGLDNVPPARSAAIGGDDSAASYRHGHVVIGGKGTDGNPLSDAWEFDYTNTFWQNITIASGPAPAARWGAVGGLDFRTPFIQDPNLKFPNTSFFMAGGFDGTDGVPLSDVWRLNITGALSSNVINQVEATWEKITLHGNPLPSRVGPAGAMVSQGSQQHIVAVGGCNSTTVTDGCEETTSYVLNIDTLAASNPPGCAAPRVGGSLALNLNQGSPSAFGSQVFLLLGTFNSSLYDDGGGLNLGEVDVFDINAGAWARVLPAGDPGSDGNVTYPTPREGAAVFSWSSALVGGSRSSATDTIVFGGRDASGQYLSEIWLLRAYNAILTESSQHWSGFGDGKLQTGANATGEGVTVGYMTDCAALLRQATPPGSSTTNPSSTSGSNPSQTNVPDSNNTPAPVSLYDTSTVHKALAPVSVALFFPAFVLYRLSLPAVTSRNIPSSRGSYLHLGWVVAVTALALGVAGLATAFTSLTYTASLVKRSPPQNLATAHGKAGLALFLGLYGLILLFIFISVFRRHSRERDDSPSRLRKTSNELGEKLGLYTHRGASPAPPSSEFPATIEEPQPRVRSWGSLALGPFSIGHGRRSSDSAIEPAVSPSSTSFEVTNRPNRARHASANNLAAFADPRPSLTPRNLSDMSWLDRRRSLNTTGDLDYALGQMSRREPSTPGTMVLEMRSNRALVNSPPPPDHPAMPRALDSFFHVLLHAFLIALSILSLTALKSRAPIAGFAVFLVWTVCFYLIIITLAWNGIPRESILTVVLHRLRTPPAHPGSSQPSAGLDGVPFPAEGHGPYQHQPMYRTAHDSDYPTSISHGGQTVEGDGDDEDDEARQRRMEEEMSRRDVSIVTVPRRKLFLTNPEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBP3</accession>
    <name>A0A2R6QBP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000366">
        <property type="protein sequence ID" value="PSS05554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBP3"/>
    <dbReference type="STRING" id="98765.A0A2R6QBP3"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="513"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS05554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="702" mass="80564" checksum="E2D78009B3599673" modified="2018-06-20" version="1">MLSEDSDNESIHQLTINEHFAKAFEYRKEREELQKLKDKYGSDVDEGEEDEEDSEDAESEDEDGEELTPAVDAAILRTLARIKRKDPEIYEQGKDVFEEEIKKTGKHKLSKRADKDKSKPLTFRQHALASALNPTSRSPSPEPLTHIEEQKALRNETITAFHTAVNVEDDEDDLLVPREKTKDELERQDEEYRDFLQREVGEDLSTLITIEDNGVLDEPTQREEEEPKEKKKKRDKKAKGGKNTEGDQEFLMNYILNRGWIDKSAKRHPTYHEVTGMNRKGKARADSDNEGDEQPSERDADSEDNEGLDEDEFDEVADRFESSYNFRFEEPGADAIARYPRNLNSLVRREDSSRKEAREKRKARKEEEMLKKKEEIKRLKSLKMKEIREKLERVGREGGKTLAETAALQELDLEGDWDPDAHDKQMTDIYGQDGEDAFNDDEKPQWDDDIDVTDIVHEEAESSEKKKKKKKKKKGGDEEGVDESGVNVDEMDADVEMAVDEEEWDGTEEMRKRKLDEYMDEIYGLDFNDMVGGMPTRFKYTKVQQQAYALSPVEILLATDAELNQYMGIKKYAPYRKDGNNWDQNRSTRLKELKTKLQERGVTSGVAGEASAGERPAKKRKGKKERMKAKEAVVQDGDEEGEDMGGGAAMEADRSRDESKSEETKRKRHQEPVEEEVGAGGGVEGTTKKRRRHKKSGVSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEJ3</accession>
    <name>A0A2R6QEJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEJ3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="23871" checksum="EB9FFA7060179DFB" modified="2018-06-20" version="1">MDQETKDCLLKATDEDKFMLLWLICFDNKPNAKYLKQLSTILREKPADEVLRCVETNGFDFDGFYKYLEEGKRAWTGHLNARLLSLADISSKQTPLPEKSDRQSTSQPQQSNTREGAPSSPMKVDSNVGHGTGSKRSSPVKATHPLDHGSPGRVPVSSPSSRHRRTPYYRQAPTMPTTRTPHYREAPTTPTKRRTTGGLRPVTPKYRIISSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF59</accession>
    <name>A0A2R6QF59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000345">
        <property type="protein sequence ID" value="PSS06890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QF59"/>
    <dbReference type="STRING" id="98765.A0A2R6QF59"/>
    <dbReference type="OrthoDB" id="2736601at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="203" mass="23466" checksum="456A87ABD140859F" modified="2018-06-20" version="1">MRQHISKALVRRSTAIKSSLERYNKLAVKQEPPRPKLEYSDIATYCLLGEFELLKDSRYGVLTQAWSSPTNREITTKHFKVLCARAEITRLNVEIARLQDWIDKEDSHFQMVVLSLARSDPLLSGEIKLRYARQRRTNDVHRARLQTIYKLPGYSGYQPTPQDNKVVAQDLSMEEAVLIDEDDVLNDEGNRLDEAMDRMSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUG4</accession>
    <name>A0A2R6QUG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000311">
        <property type="protein sequence ID" value="PSS15393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUG4"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS15393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="21667" checksum="B057C2CDD58E8B01" modified="2018-06-20" version="1">MPDSDYLKPTTEGIFEDCPRYELSGVGKSSLINAAFKVDLAVYPHRRIFEDVYTLPSVPFIVVFTKYDQFVSAKEYELLNSLNNLDDMTDDEVEQTVQSRLGQDFADLCLDKLRKVSPELPLWVYVSGNYRKSSRYQLFPLSNFNLVADARYTETLKGLLGLTHKHIVDSVSIILASAQRVDATAKIDASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXK7</accession>
    <name>A0A2R6QXK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000297">
        <property type="protein sequence ID" value="PSS17126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXK7"/>
    <dbReference type="STRING" id="98765.A0A2R6QXK7"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS17126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="291" mass="32446" checksum="7515EC8557164CF4" modified="2018-06-20" version="1">MGKMGAWNAMLEQYTRLPPALKASPSLAGRTVMVVGANTGIGLEAAKHFATMNPARLILGCRNEEKGREAVELVTKETSCKTVELGLIDLANFESVRAFAKTYENDPLDILVMNAALAVRTYETTEDGWEQTSYGEDLKPENAPSMLEKLNERAYCTQKVMETRYPDSKCMYLSLMQFFVARTAEQGARQLLWAALGPDGKDGEHVKYLNGAYVSTLEVKEPSDYVMSKDGYEAHERIWRRDLTCDGVFIEGNPFYPGTPSPNPSSRSAEASASLRQAFHIKRWIKRPGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R109</accession>
    <name>A0A2R6R109_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000284">
        <property type="protein sequence ID" value="PSS18917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R109"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS18917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="8624" checksum="F7CB52FCF7274E69" modified="2018-06-20" version="1" fragment="single">MASSTATPPSALAALPSQSKDSELLKTREEQRQSFIYLASTTENVVLELNRETVSLIPWACSIGANIHKLRKSGPSPAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI32</accession>
    <name>A0A2R6RI32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI32"/>
    <dbReference type="OrthoDB" id="2740821at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8330" checksum="805695A296B70B5D" modified="2018-06-20" version="1">MSAGFTSSFYDRVGTHQFQPPTQMWGYWPQLNEWSRNSIEWNIVRVGGADHMPVFEAYPICVYSIQSLAEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI63</accession>
    <name>A0A2R6RI63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Spindle pole body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v2867</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI63"/>
    <dbReference type="STRING" id="98765.A0A2R6RI63"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="191"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS29719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="68626" checksum="BE34DBE234AF5216" modified="2018-06-20" version="1">MSSAHHVLDDSLDAQRPTKRARVDVTPALPEGTDNSTVDTRETPLDEEEDDEEEESGRGQTEVSRASDLYLDTINRAALDFDFEKLCSVSLSNINIYGCLVCGKYFQGRGRKSYAYAHAIHDDHHVFINLETTKVYVLPDGYPVSDPSLEDISFVLSPSFTKSSIANLSSPAHLTKPSYDLSSRPYMPGYIGLNNIKRNDYMNVIIHSLLHIPPLRDALLLSNFRGKESELLKRFAGLAKKVWNPRLFKSQVSPHEFLQEVGRVSAGKFSLERQGDPVEFLGWLLNRLHKDLGGTKRNTSSVIFSTFQGAVGMENQQVVVRSNLRGSAKPRFDIDREIKSSTSPFLFLSVDLPPPPLFQDAVEKNIIPQESAGQLRRFKLQRLPPYIILHFKRFTKNVFVEEKNPTIVNFPLRGLDLRDFVDAPSSHSSTLYDLIANVTHESAAGTTRDKASTVWKAHLRAGAGGGESEQWFQIQDLIVEEIRKEMIFLGETVLQIWERRADTPPGTLNPKMDIDKSWHIPAYPPAGAEQHPTMRLSEFGFMHLRVLRSHERGQGYQMVARSKRLCRVAFLRWRCLDQSCQTKINRSDLNLCLQERYVTSVLRAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIF0</accession>
    <name>A0A2R6RIF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000255">
        <property type="protein sequence ID" value="PSS29802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIF0"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="10636" checksum="5739FFE59A781D40" modified="2018-06-20" version="1">MCLLWRARQQKLGVDDFGNPVSLGTVDVDPQMEDSPIPVTQGPEGGVRVEEAISAAVETDMHVGHEAGTVDEETPLLKKDAAERQVGWFGRLLPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIL7</accession>
    <name>A0A2R6RIL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000247">
        <property type="protein sequence ID" value="PSS29876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIL7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="14485" checksum="9FFF8F5933FAF9B4" modified="2018-06-20" version="1">MSTQPPPPIPAFIASPMTTATFSCAASVDPFMTSRAAMSFTGRPLTPLFCHNNCWISDGLDHLPLWPTPAQTQSSTGGGSVEYCAILKNVSHNALMDAENSAYLQLHDAYHAAKSECTMLDFYKVVISNLTTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLK5</accession>
    <name>A0A2R6RLK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2529</name>
        <name evidence="1" type="ORF">PHLCEN_2v8513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000849">
        <property type="protein sequence ID" value="PSR76339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLK5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="8916" checksum="FBAA7663C5175553" modified="2018-06-20" version="1">MSLPEYIHESDEEGSAESPAFIPKEWIGNGKQWVDTMPQCVVRARNEARRIPLGVLANIVPQQGTPIAAVLRCYTPPTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM68</accession>
    <name>A0A2R6RM68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000218">
        <property type="protein sequence ID" value="PSS31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM68"/>
    <dbReference type="STRING" id="98765.A0A2R6RM68"/>
    <dbReference type="OrthoDB" id="3264126at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9447" checksum="11E4F6225B27BD59" modified="2018-06-20" version="1">MRRVNPVTLLPQISEAQILSYAKFLSEDIGYRTVGTREHALGDAWMVEQAKELQKQCEEVVKGSTGRKLECEVWRQEGSGSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPJ0</accession>
    <name>A0A2R6RPJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000213">
        <property type="protein sequence ID" value="PSS31937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPJ0"/>
    <dbReference type="STRING" id="98765.A0A2R6RPJ0"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="524" mass="57976" checksum="040709ED5E3E36D7" modified="2018-06-20" version="1">MDSHSVSLNPSKGSNEQRIDVPMRSFQGGYYPQLIALYKHLGVKFRQADFSYSFSTLTNLSDTLQRQITTTMIYNGASGRDGVSMPSNMLPPTAKSSLLSAPSSLVAHLHIYVTFMLSMFLLVVFYLRLVLFSLPIQVPESISSSWVAFSIPLWLPFPTRPRNKCLTLREWTERTTPNNAISRWLKLDVQWQHFVKEVLVPLFSAVCTAGEDRIWNHPVEELLDYIYLTFGTHHYVVLNGVRDVVRKITTPVPPSNIHLSTPIVALVPGSPDGVSVSTVDIHCASNVVFSGFEHVILATQANHAGPLLKAYCDRLPESTSPDSSHLDHHRDLVAAQTSCLENFEYCRTIVVNHTDSTLLPSCPRNWRDLNLVMTTEPPLQADASDLCLPPTYAMATHILPKLKGVYQTTNPIVPPAATTILSVAHLERAVVTICGKNALAGLWQEREENKWKWGCAGSDGGRLGSLQGAGRSRQCRVPGIWICGSYAHCGIPLLEGCVVSARNVVEQGIWASEDVDLSTLPPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPQ3</accession>
    <name>A0A2R6RPQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6RPQ3"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS32003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="26097" checksum="7C1F65F51EBDBC0C" modified="2018-06-20" version="1">MTVARFEPTGKHVFVGTSSGQFNLPTYGPPAADGAYIEQELEPTYRFSDPINKVAWHAISYSPDGEWLAGGAADNATHKIYIWDIANEGQFAAALDGGREPLTHVHWHPQKPSIASTTNQGNILIWHCPTPERWGAFAGGFEEVDENVEYEEREDEFDIVGVRQEDEGEQALRKQKEEEEEIDINGAEEKGDRGDYWNGDDDEDIAWADDEPDDDLPGWKLKVIMEEESDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ74</accession>
    <name>A0A2R6RQ74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000192">
        <property type="protein sequence ID" value="PSS32159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ74"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ74"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000039">
        <property type="entry name" value="Glutathione S-transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS32159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="222" mass="25059" checksum="B667CD016B7E7CAD" modified="2018-06-20" version="1">MSHGKQFTLYSHKGGPNGWKVAIVLEELGLTYESIYLDFQKGEQKAPEHTKYNPNGRIPTLIDHKNNDFTLWESDAILLYLVSKYDPEHKISVTGEDEKFHLTQWLFFQASGQGPYYGQAAWFIYFHAEKIPSAIERYTNEILRVLGVLESVLSKQEWLVGGKLTIADLSFITWNQGALAGPLPNKEGFNFQKDFPAVSAWHAKLEARDSVKAIAAAKAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVM5</accession>
    <name>A0A2R6RVM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000161">
        <property type="protein sequence ID" value="PSS34056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVM5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="133" mass="14882" checksum="E7FD46B975BBB675" modified="2018-06-20" version="1">MKPPRINVNQPSEETTPFTLVIPFTLSPEGGFPCVHFDDALGMYDNISQKQYQDWRNFPRTSEAECVLVQVYNQGPPAPKMARAVTDKIKHTLTCLIGYNKAMISYPTPMNPSNRDSKGETKAAPHSEHTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZQ8</accession>
    <name>A0A2R6RZQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000121">
        <property type="protein sequence ID" value="PSS35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZQ8"/>
    <dbReference type="OrthoDB" id="112749at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34204">
        <property type="entry name" value="RNA-BINDING ASCH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34204:SF2">
        <property type="entry name" value="RNA-BINDING ASCH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="25498" checksum="18892EF9BA5ACB10" modified="2018-06-20" version="1">MDLEAKISLLSTQSDTGTPENNTASTSAFIPTPYCYNMLEHPSAAQERSTLNSARASGDHSVSKLTNSLMVHLSHGLAYTVGSALGCSPPSQQECLAAFVAPNKVGLTAGARAWSKHAHRSGGSETNAVGWWGTPSGPVATINECALLLFWRTMSAVSWRNLHWLPHSVLVYEMRMPEGYGMRWSQDQNSLLDDDGKIMDEKLDQLEERMWTFRGFVEPMMENGHETGWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZS3</accession>
    <name>A0A2R6RZS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000124">
        <property type="protein sequence ID" value="PSS35497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RZS3"/>
    <dbReference type="OrthoDB" id="2687259at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1318" mass="148808" checksum="CB90313BAA384E81" modified="2018-06-20" version="1">MVQCVCGREVAAGTGLTLHQRTCAEALLSFSKAMKRKREAAEEKRARKRQRKDALTAAQDAHLQDEPPSYEMPTPELAPEPVVLSNYTEASASGRRLRVHRAPKRMADFLPQSLTSLRGLPAYFRPLPPPPASHTGPTPPASISEPVEDPSPPPGPKYINGQPNSFGLYRSYLEMPSHDPEVALSLDSACDVPTLSIAKPQRPPWWSVFGKAARQVVNTQFTPFLNATTFRLMSWFYSGSSAKSLAELDRLVQEVILAPDFDRNEITDFSALRESQRMDDWIDEDSSASESFRVEDGWHEASVQIPVPCERTKWASEHDAPIFTVPGVFYRRFVDILKTTLASETAQTFHMIPYKLWLLPSNSPANAAAAETASDSPANADRVYSELYNSNAMNDEYEKIKSSPRASACDLEIVVAGIMLWSDSTHLAQFGNASLWPIYAFFGNQSKYVRCKPTEFAAHHLAYIPSLPDTIQDWYQETFGKAATAAVLTQCKRELMHAIWEQLLLDEDFMHAYEHGIVIKFADGISRRVFPRIFTYSADYPEKVLLATIRYLATCPCPRCFVRKPNIAAMGTKTDLKRREKNARLDDGERRRIIKMTRSWIYEKGVPLTSKYFDEVLGTRSWVPVRNAFSVKLSPFGFDFHSMLAVDLLHEFELGVWKAVFTHLMRILYAAGGDKIQTLNTRYRMIPTFGRGTIRRFVKNTSAMKKLAARDWEDMLQVAMPVFEGLLDEPHNHLVMDLLFELGRWHSLAKLRMHTDTTLAVFEQSTSSLGTLLRRFSSEVCSSYVTRELPREEAARGRRTAAKATQSKGKGKSSTKPSATGPHTKTFSLSTYKLHALGDYPNMIRTFGTTDSYSTQTGELEHRRVKRFYGRTNKHGFTRQIAKQHMREELIRRIGKRVENAGTLTMVTGADKIHSTAKKAPTTTKSSLPTLSFADSDPLPYSPPEQHHHISQSNRFHQDLTDWLSVNKDDPALKRFMPRLKDHLLSRLSGKEYDGDEQEYTDTERRQVIFINNRIYRHKVVRINYTTYDIRRSQDSLNPRTHADVMVAAHEDQDGNNPHPYWYARVVGVFHADVLHIGPFSKTAEPQRMEFLWVRWLGRDMDVPAGFRKKRLSRVGFVSNFDDDPGAMPFGFLDPGEIIRGVHLIPAFAHGKTSELLGPSMVRPSSDGDEDWVYYYINMFVDRDMLMRYLGGGVGHRIARLVADGLEAAPTDHAEETAHPEVDEVEPLRLPDPDIIGSELETSMLEDDAEDGEVGDNLDTGMADGEDDYGYNEPGPGEESEDEDGGNEEITEEDLGPEDGEDDVGEEGLEYEEGFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZU1</accession>
    <name>A0A2R6RZU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000120">
        <property type="protein sequence ID" value="PSS35536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZU1"/>
    <dbReference type="STRING" id="98765.A0A2R6RZU1"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS35536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="216" mass="24414" checksum="603B606EEA5D34A2" modified="2018-06-20" version="1">MSAGSSNQKPFVQAGEPLHEFLPLFWRRQMDAAEQETPDYRHPPLPLARIKKVMKSDPEVKLNRGAPCSCLSLSVFISEITARAFIIADSNKRRTLSRADIAKAVSKSDQFDFLIDILPREEPFTMPANGGIITNPKAAGKKAGKEQRTSIFDRNRPLEAGKKCRVDKHQLGAKSRAPWFWWIRQAVPYDQCISLTHYFMQLQTLLHPSGPSEPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3I8</accession>
    <name>A0A2R6S3I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000096">
        <property type="protein sequence ID" value="PSS36841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3I8"/>
    <dbReference type="STRING" id="98765.A0A2R6S3I8"/>
    <dbReference type="OrthoDB" id="3364670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13695" checksum="C8CD57E1AF791B30" modified="2018-06-20" version="1">MEWDRLDQATGGCNIALGTKLHQETWKKISRQKPALITVIKKFNGYCERLRILCPINSTIHMPEPLPLDLVALRQHPCLMEDVWIAPAVNSAPSHWLEDSNIRAGILAYHKSSHCQEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S477</accession>
    <name>A0A2R6S477_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S477"/>
    <dbReference type="STRING" id="98765.A0A2R6S477"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="568" mass="64806" checksum="CD27BA776D22FACE" modified="2018-06-20" version="1">MAGSRSDLTHAVGAIHDSWGYNSDGIASHGNPMPDQYAPKFHAGDIIGCGTMYDLCGGSIFYTLNGSFLGIFFKDATERCESDEFFPSVSLCHPLDTVRANFGQQPFRYPIARIIRDSSRETQWPRPPKPPSFSSEIIYIILGGLAPNNDMDKTHMVSCSLVCRYWSRILSPYLFRTIKLQSKDEMDVMSAQVDNSNRQMSAAIISLTVHERAHDVWAYKVAMSLANRCHNLKTLTQERDPLDRLGWEIIRQCTPPGISRSLPALYSAYRAVTTFVLINQHFSSFAALTQLVSAFPVLKTLKCERITWDKRPDNPRLLRAPRCLSTIQVECCDTDWRMARLFIARWGRLPLDWDPSSKSPELHRNDSLFVHGLLNTEDTQPFDTSELLFASSTDNHAWHLKMTLMDRSRTEAMKWDFIFCPRAIQDHIIKTCLTELRICMLNSFDPDEVGPRIPLLDKLFSEAPLAFLANVTIVSSEYMSPEIAAVKTSKLRRHLSHLQAAGKLRLCLSGQTTAGHEEQGEQEITEEVEQFVTERMRIEENERAEMICMEESQWAERISRWQWGEPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4D3</accession>
    <name>A0A2R6S4D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v986</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4D3"/>
    <dbReference type="STRING" id="98765.A0A2R6S4D3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="656"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="841"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="149"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="333"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="618"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS37113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="900" mass="98325" checksum="75B43E99200B4F6F" modified="2018-06-20" version="1">MLVQSQALITQLVFNHALRVRMKAEVTNSSSSATSTAATTPDSASIAPSERADSPDGSEEDTAFSETTSATKASKGKHSKTASTSGQSSKAPEQPADGSQSSGDSKAGNFVGKLNNLVTTDLNNLIDGRDFLFVGEFTRIALKHPGLDIGLAVIIALFPIPGYIAKLVQGVQKEKMKKTDARVQTVTETMNVIRMIKIFGWEPKVNDQLAQKREEELGYLKKFKLLELSNGLMNFAIPVLTMIFTFMTYTVLMKRQLTASRVFSSMAVFQILQENLHTIFGMIPMIIQAKVSLDRVDEFLHKTELLDVFATGTGHETSSIVPPAEVDSSVIGIRAATFTWSSDHDGTVTPGSNRRNFSLRIDNEVTFKRGSINLIVGPTGSGKTSILMALLGEMHYIPSGPESYRHLPRDEGVAYAAQESWVQNETIRDNILFGAPYDEERYNKVIYQCGLERDLTLFEAGDKTEVGEKGLTLSGGQKVLAALDVHTSKWIVENCFKGDLIRGRTVLLVTHNVHVARPIADFVVSLGSEGRISSQGSLSKALASNKKLAAEAKHEAEEMNKVEEAVNETAEPSAAPVAKSDGKLVLAEEISEGHVGWPALKLYFANLGGDTPIVFWTLFVGGMFFTVLLETVQAWYLGYWAQQYETHDPSEVNVSAYLTVYSSMLLVSVVIYLGACFVFVYGCLRASRAIHQQLVSSVLGTTLRWLDKTPTSRIITRCTQDIQAVDGPISMYLGYLTEMTITMMMKFAAVVVISPPFILPGILVFVLGGWCGQIYMKAQLSVKREMSNARSPVLGHIGAAMAGLTSIRAYGAQDAFQMESYKRIDRYSRAARTFYNLNRWVCIRIDVLAGLFSAGLAAYLVYGEGISASNTGFSLTMAGMFARILPSLQSLILPKSGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S541</accession>
    <name>A0A2R6S541_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000044">
        <property type="protein sequence ID" value="PSS37410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S541"/>
    <dbReference type="STRING" id="98765.A0A2R6S541"/>
    <dbReference type="OrthoDB" id="3197614at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="417" mass="46513" checksum="9597B1FC8F5E8C9E" modified="2018-06-20" version="1">MLYNEHSKAGKELQRKIAKLREENKDPSLPQKVPSRMAAAAGSAISTPLIPPQPQRSPPLHLTQNQLSESQQTVDESFMLLGQKSEPGDAFNHFWKITEGMLEHLSQPVAFATAPLAPPSNSPSGSRRRDGNASSDTDVEDPITKTLNRGLDFVKAARSKMLIRNDSGTYTSDSDSGRPGLSTFPPKPQPIGDDWDEDVGFDDDDMADSFCLVPSKADAPVSLLKKENAVLKDQLEKERLKLAVAERMLKQRQEQDQHLRDSIMLARKEAQRAMTSSMALRPQQLPPPIIPAPPPPVDIAALNINVPPVLPPLVPTNAGLTRDREAQLVRRVRELEEDVRTMRIENDKQKAMIAKFRERWEKLKESAKKKKEAKVAAEATNVVNDRIDEDPEAEAEAERDDLRPRKHTELPSPPEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5M7</accession>
    <name>A0A2R6S5M7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v607</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5M7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5M7"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="168"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS37591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="572" mass="62047" checksum="BB9FA52D25C85359" modified="2018-06-20" version="1">MAPYHDQPDSPSTTNLLAPGLSSGRAPPSLRSVASNTSLGSQSDSRYAVVGDGSSMRGGIPPSISDKFAMSPDPSSWGGDLSPAFREPDDELHNPDPRRDRKSDKGGTIFTARGVSNLGCLVILFSGMAMLFAGYPILSHFLKKPQTTSGGFNLGGTNATGQVPSMVGNWGLVDLETPKEVYTKADYVTGAQWELVFSDEFNTDGRTFYPGDDPYWEAVDLHYWQTNNMEWYDPAAITTRNGSLEITLSQKDTHGLQYQGGMMSSWNKFCFTGGLVETSVVLPGINNVVGLWPAIWTMGNLGRAGYGASLEGMWPYTYDSCDVGTVANQTLNGLPLAATENGDPSANGALSYLPGMRLSRCTCSGESHPGPMHSDGTYVGRAAPEIDIFEAQITGTPLTGQVSQSGQWGPFNEEYQWFNTTDNLIIPNATATFLNPYMGGAFQQATSGVTESNQEAYELTGNVYSVYGVQYQPGFDTGYIAWIANDELAWMLKQPGMAADTRVEIGSRPVPQEPMYLIANLGMSRNFGFVDLDHLTFPATMKVDYIRVYQDPNMKNVGCDPEDFPTAAYINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S719</accession>
    <name>A0A2R6S719_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v80</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S719"/>
    <dbReference type="STRING" id="98765.A0A2R6S719"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="144"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS38100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="244" mass="26723" checksum="19308CDB521C715F" modified="2018-06-20" version="1">MQGNMWVESEVSNGSRFFFTINSQISHMSVEATMIKMSPFRGRHILFVDTLDDDTGVAQTIEDLGLKIFHVHGVAEVADKASCPHIDTIVVDSLYVVMKWCLDNSISSQITKPVSPPDLASALISALESNTVTPVVADTEVPYDILIAEDNLVNQKLAVKILEKYGHTVEIAENGQLAVDAYKARAQRKQPFDIILMDVSMPFMGGMEATEHIRSYETLHGLDPVPIIALTAHASKQTGVTSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDT1</accession>
    <name>A0A2R6NDT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v13627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDT1"/>
    <dbReference type="STRING" id="98765.A0A2R6NDT1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="407"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="498"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR70476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="529" mass="58304" checksum="2DB6802A160CA7A3" modified="2018-06-20" version="1">MDRGGGGGPSRRKSSLPESLHDHILPRQVLPGTSTLTDEPQSFTETEEQQRARIPRAAHSFPSVWTPPPPLPSTLLSPATFEEGSSTGAGTLRWLSATTHLVSPPRFEGVQVTPRPPDVSPSSDQRFFPAIPPSFSRGHSLSSATALPHLSPPVRAFESVPHLPPVNQLLRHLSDNHRLRSWSPGDFRNVTLPPIPNLSLQGREVTGPRRLYERRARPSRVHSAPYHRNLPDVQRSNEPAHVEDLSHWERRDIEAHHRVSVAGPGPTREVRSASTPTGGLSPRPPFGTASEHDRAQSTPRAAFASQPRESSARSEERERTVRRDDVQRSLDPTSQGGPSEKEPGNRLSKARQPLGVEAGKARQRKATEALDDDDDETEESIRTAKKTQLACEFCRRRKLKCTGLKPTCRSCQKRGLPCEYPVEMKRRGPGKAPKRQRTRMQEPKSAQQSSGCASATSTEQGEAPTQRADISGQQTPQRQGRRTNSQVSATTPASTSNDADHSTELHEFIHDDQAPPPPPPQPPPRREAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF44</accession>
    <name>A0A2R6NF44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001305">
        <property type="protein sequence ID" value="PSR70878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF44"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015336088" evidence="2">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="225" mass="23920" checksum="210B04CC7228F8F9" modified="2018-06-20" version="1">MPSLRQTLLLSTLALAALPVHTFPAGPGMPTRPEPTPLIVPLEPGMLLGRHYYHHQPPFPKREPLVLMDPALESQFAKASPPPPSASSHNAEHPSASKEKGGSSGKKEKKKTEKKGGATTRRYGPFPRYLAERKGAMVQMRDDVNDVSNVGPSSRGGTAETSSSDSGALAPPAVPSNAFITNHMNGTDHSPHVDRSKAQDKDKSVQKSAGKSSKSKGGKESKTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFB6</accession>
    <name>A0A2R6NFB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NFB6"/>
    <dbReference type="OrthoDB" id="3265815at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36126" checksum="8110161F34750D81" modified="2018-06-20" version="1">MGSFDYPSPSSNDEIHKPTPVGSPAVQEPDSEQTLVSVSRAFHPRAQLDPLEPDVIIVTNDEVFFYVHHHVLVSASQNNFNFHLPDNLDHAVPLPFILPLPEHSNEVNIVLHTMYHLSCNHYAPTFETLLSALGILRKYGIALSLYTSHFATPLFGLLLSHAPAHPLEIYAIAAENRLEELAVAVSPFLLSFQFSSLTDEMAIRLGALYMKRLWTLQHNRLAVLRQLILALPYMHPVDAESSCDQGAVIKAWAQAVEELAWEARPDLTCNAIQVAFMCPGFQFPCSLCKDLWNARVQEIVTEWSLTKKDSRQLVLRECKIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGS3</accession>
    <name>A0A2R6NGS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isomerase YbhE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGS3"/>
    <dbReference type="STRING" id="98765.A0A2R6NGS3"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="37822" checksum="7C50A296E382416C" modified="2018-06-20" version="1">MVHRIFVGSYTKEISTLSFDPDTHSLSLDSSVTVGHHPSWITRHPTRSSVILTGVEQADGKIVAVLYDDNGKGTIAAEIPSGGADPCTLLAVDNNLLVGNYSSGILATIPLVNDPPFVKGTGITTLAFNGTGPDKERQETSHPHQVFLHPSREEVLVPDLGADKTWRLTKDANGVWINQGHVDYKPGSGPRHAAFYNDILYTLLELTSEVSAHRLPPLPSQPAFITAVPTMSKFPGPPSVLGMLAAEILLPVPNKSYSTPYLYVSNRNDTSPEGDVIAIYSVADPEKIELVAEVRSGLKHLRGMLFGGPDEKYLVAGGVQGGGVKVFERIDGGKGLKEIASVDLEAPTGFLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHL7</accession>
    <name>A0A2R6NHL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHL7"/>
    <dbReference type="STRING" id="98765.A0A2R6NHL7"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="497" mass="53864" checksum="12CF826F9E7F6813" modified="2018-06-20" version="1">MSLESVPLEKDDKVSASASVAHSVDSEAASGHTAAFKRHGRVDLVPMPSDDPQDPLNWPSWRKNLLLWIVSFHALQGPFGAAVAIPAFEDFAVEFGIPLNTVAYLVSVEILFLGVMPLVWAPISERIGRRPVYLISALVSAGCALAGAYCHSYGTLMVSRVFQAIFISPPLSIGASTVSEMFFSYQKGRKMGVWVLLVTCGPVTGPLVTGYLVQNKGWRAAFYLLAAIHLALFFAHLFFGPETLYPNRAAPGEEPKDAVVSTWYSSYKFQLYSRKPLQLIELWRPFTMAMRPPVLLAAFAIAVPFAYIGVLLIFGQVFHLSPGPIGLQFISLIIGAVLGEQLAGLGSDLLANTRTKRAGGIRLPEYRLPLVYPGFVLAIIGVIIWGVQLQNATPGVWNVTPDVGSAIAMFGLQIITTICTTYAIESYQSEAASVSAFLTVVRQTYAFIAPFYLPIPFEQWGPGKAAGLFAALITVGAIMIGACHIWGRKWRGSTSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHP4</accession>
    <name>A0A2R6NHP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHP4"/>
    <dbReference type="STRING" id="98765.A0A2R6NHP4"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF66">
        <property type="entry name" value="HISKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="438"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="932"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="751"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="823"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="888"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR71904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119015" checksum="80DC3BCDAF00A39C" modified="2018-06-20" version="1">MPFRSRISLASALTTTSSMNPVSSSKHAQAETIELEPSTTPLPPDDGLPAPVQASNYPSPSRKQKRTRINLGFHIHWDRFLRKLGSGTAPSTSSALDESSGDSTTVYHRSQQGRSGGGGGVGGGGPEDTDAEVDEVVVDREWSSEIKSSVHSEHGGSPEKSGGSNPQIGFGGTSTDRDSVAVHDGFWTSCTFLVFLRYRIWPVVLAFFSTHFMDDKSEQHYKKENWFLRKSLALWAAAFYIINWALAIAFIPHPGDLADKIFYYGWTPVLTFPLFFMVVYDFPRDRPIFYQIYLAFSTWSWSCFQLIFMFLCGFYASETSRFDCEHKDFLLTFYYTSAFQTISLFGLGFNRFPAMIGAAVFMCMAWGFTVPEQTSFTRNVINFIIYQAFLLYVHYMRENAERRLYTLRDQLKIQFRATQKAQVNERKAADSKRRLTSYVFHEVRVPLNTALLAVQNMEASGTVAKTQDIEFRALEGSLSMMSKVLNDVLDFNRMDSGRFESVLKPYAFHQVMRSLFVPLRLAADARSLEFVYDLDPNIDEVARYALYEARGENAEGIARLFSETPENIGLVVGDETRLRQIITNLASNACKFTPAGGKLIISTRLAIPARSPRTVNKDGQDLAADQPVSDEKDEKVSQGLSSVLLSQHDGIYSKPTPLEWIVVRIEVTDTGCGIRPKDMVQTKLFSAFNQTEMGRQQGGKGTGLGLALVRQIVKRSGGRLGVRSKANEGSTFWVELPLGVGNKVLAGLGTPEASSASGDNTSRNTLHLRRPSASVRKSPLPHVSSSSSPTSEGSRESSALHSIMEQAGLVEISTKRGEGAILTRTIGDPSTGTEPVRADSSSPSDHSSATQVSTPPERPDTLNEESSDTTIKLPPRLELPKARDFIIEDPTADGAPPASPVAQVVTPGSTSSTAALSTTTNSSTITYDSGMRVLVVDDDTLTRKLMSRMLTRLGCLVTTAENGEIALDLILSGTRPTPSSEDTGSSGLLDAPSPVAAEEYRYAVVFLDNQMPVMSGLEAVTKLRHMGRRDFVVGVTGNALLTDQQEYLDAGVDHVLTKPVLEKSLKSMLAIADERRKRGDRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI37</accession>
    <name>A0A2R6NI37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v12074</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001223">
        <property type="protein sequence ID" value="PSR72044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI37"/>
    <dbReference type="STRING" id="98765.A0A2R6NI37"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR72044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="644" mass="72247" checksum="C8EB5B786F0318A1" modified="2018-06-20" version="1">MGEEIQDAFPASKLGEYTVIQEIAEGTFGKVKMAVHTITGHKVAMKFISKQVIAATKTKTRVQREVDYMRALRHPHIIKLYEVIATPTDIIIVLEYAGGELFNYIVANGRMEEPQARRFFQQLISGIDYSHRLKIVHRDLKPENVLLDDDLNVKVADFGLSNEIKDGDFLKTSCGSPNYAAPEVIRGGLYTGPEIDVWSCGVILYVMLCGRLPFEDEDVQTLFTKISQGVYHMPSYLSAEAKGLINGMLAVDPVKRITVPEILQHPFFTTELPRYLQPLPPRPGPILGPLSSLVSPPKALDYEIIEGLGRIEEDVVDELAARMEGVERDDIWECLRRDDGPQGNAVKVAYMLLRDKRRLGRDLAEFEEQERDAQLAAMDPRNPLSPNAMSPGGTELEENPFDTEFNDCGEDDDDDDGLDFSTPQNESENNFAVLNSSLPLPDQLPEQHHLASYVSAKRAWPVKEKKQHRTKWHFGIRSRSPPMEVMLEIYRTLKALGMEWKEKSDLGGLGGIQKGRSSERAKLERAREYDGGGYVDLRAASSIYFIESRARVGDVVVLMNLQLYMVDSINYLVDFHHKKTYKASAEPGAGNFEMAHPDSNFSETASESSRSVKDISIRDDEVISPFVFMDVACRLILELAGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI84</accession>
    <name>A0A2R6NI84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001217">
        <property type="protein sequence ID" value="PSR72094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI84"/>
    <dbReference type="STRING" id="98765.A0A2R6NI84"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="215" mass="23694" checksum="FC46E44F7EB4FA2A" modified="2018-06-20" version="1">MPVQRHKRTFMPRTLPCTWKGCRQLFTNTSGLKRHVASAHQAFGAALKSMLNPLTPALPSVPLSGAPVLASLDFDDLADRAADGQGPRNMEAEPSHAGFQRRGGPRIEIHPRLDGTPCDTNGNDLPPATPPLPRAQPSGDDYSPFTDRTEFELADFLYRKVQMPGGRIDELMQLWGADDHHPPFADHKDLYNCIDAIGVGEIPWQTFSISYTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI95</accession>
    <name>A0A2R6NI95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001213">
        <property type="protein sequence ID" value="PSR72115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI95"/>
    <dbReference type="STRING" id="98765.A0A2R6NI95"/>
    <dbReference type="OrthoDB" id="2747940at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="464" mass="51668" checksum="DAA8195E027C5C87" modified="2018-06-20" version="1">MQNATALIEETDKLTLQTLNTEDPSIRWSKTQTNPLPDPTERFIMLTSLNNDGSHFQPAQITGLFAKLKYALRLVMLVEIKSQNNGGDAEQDLSVCRALGDWIHEHRTHSTFNRLCSLQHLASGFAYGDQKLPNIWWMDRVNWSKMLYKGDELSLANIQSMFANLEKRTTALWEQDILLGLQLRAEYTAIKEDLSNQQVGYSFLSDTRNPFLACRDTLVTPVLRNPELKKRFIYVANGSVQWRKTALAVWLANYTELNQNLMDDNLGDDYIGAEQTGHTVDTERMKNAVSPEALAGLPEDLFPLFLQASSEWQKVMKIVPGSLSLTYLEAGCGHFQALVEQKKISMKKVSNTGLQAAEINTEEIAAKVVNQITPQLLQHIDTMSNTIVERILAKLSSNLVSATPLPNYSAGSTITSLSALVPTPLSPSPPSSPVMLPSPPLPSAAQYPQICHHPNLYPSVSHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIP1</accession>
    <name>A0A2R6NIP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001240">
        <property type="protein sequence ID" value="PSR71862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIP1"/>
    <dbReference type="OrthoDB" id="2751164at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="14619" checksum="4CB13BE6508FBC4D" modified="2018-06-20" version="1">MVYPDVSGQYAITQETITITVDPVFGGYCGFVLNIPAKTYFKLAPILISRFLLNLRQLGEPEVETQFNSRFSIPGFRVPTSINIVGNMGADLDHGFSEELDDESEDGAPNGALDAVSVENCSGTSVENIGEIQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIZ3</accession>
    <name>A0A2R6NIZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIZ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NIZ3"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="260" mass="28647" checksum="3DF28C2287728D62" modified="2018-06-20" version="1">MFYYEVQILQGEFSSYGTQVFGHIGPQSNSWRYHSSGRFSIGNGDMIGAFGPAYEAGDIVGCGVDFYNRRIFFTQNAVLLGIVSTDSIGISLSTELCPAVGLASGFSDISIVANFDCTPLFWESLSSCYTKRLAALNTEARLNVGKPFFVAATRWRAKHRHNSIEVSHDGRDIRKIRPHSLSDTTAVSARGDSITVFEDGVSYYEVEIVDLAVDGFADPWTETWDHAIGVLKGTWGYHSNGKVYEGSPYADRFAPTFQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ05</accession>
    <name>A0A2R6NJ05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001193">
        <property type="protein sequence ID" value="PSR72367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ05"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ05"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="240" mass="26966" checksum="5C376915EF03EFFC" modified="2018-06-20" version="1">MAAIYGIPAAANYHTTPTHPTSKQRGYRLCDRCGSVEQPSMRFRLCGGCSQECQKMHWPTHKPICQHTSHQISSSKQQLMGVGINEDIVKGLRKFTSAHATLLGWSGFQALQLKRMPSNVRQHALLIELAYRPSTDSLRRFSIKSTHVVPRTYVTDNDPLVGEDIRRREDRCRKSGGIGTAVIVIQCGEISQVMPVEVDSPSRISWDSREDWTEVLRHFVDSGRTDFKPISTTARGIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJJ4</accession>
    <name>A0A2R6NJJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJJ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NJJ4"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="329" mass="36947" checksum="3A818B6974571227" modified="2018-06-20" version="1">MLESLRPRRTYAPAAYDPAQKMLLDRPSTMQDVADFVTEYINSDSLGIIATAWLVIADQSSQGIFDQDCLTLSALHSDAVDYPKSGRPVPLTKIPKYKFRAKPDWNAPETVISKDSTKYYQSTKAIGRLYREIDLPAVATARSAQRSQRRDVTNGQPRRLDEVLEAFHDGGYYDDGEAFAAVQHRVEDHISIGRHDDDLVAEIWELFRNYISQLQTICADHSLSHKKDAMLTEEEAVVGSIVAQCSQPRKRKDLMSKLREQTTALVDDILNDLSGEVGTLPEKSLERAMVALRISTIEEKLFGAKSFAWIAMGEIFEAIKTIETSEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKI6</accession>
    <name>A0A2R6NKI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKI6"/>
    <dbReference type="STRING" id="98765.A0A2R6NKI6"/>
    <dbReference type="OrthoDB" id="3515175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="660" mass="72170" checksum="07C216B5BDFDE119" modified="2018-06-20" version="1">MGQRHQAFVIARIIPHGATQPRYRCVAAYHHQWCYGVLPLYAARRFLTLAQQKDNAEIIREELHSLSGKYGTFGNEPAIPDTPCPFLASVLGMSWDIDLDSGYSSGGTITNSLLPAGMCSWDGDNNDGISIIDVTDLENPAYCFATEAEPLTATEYLSGYYSIPGELNNGNIDVDEDNVEPRSDENDKKVRAAIGILDGVRLIDLSALHEAWPTEYRPVNTESTAPAEPSDAGNPPVTIPSLVNFSLPQAILQTIEGGDTTIIEQLLWLPGKRKDVRDVLQAQKPYPDEGLPLLAKTLKELSDTPLSVDLSGFDLADAQVIALAQGLEGVEALNLSRIARITIDGVREVLTLLSSGLKRIVLMNCESIADEDIWELLRTKPSLFYKLEALMHPALLQITQNPSRTPAITFLTLPNDSYRGVSLPIFTPAGVIQGLTDFIASMVLINPWQFDATGGAIITAACTASPRKPGQSWNERNIVTAPSLSFDTLSNDIGGWIFIVRCAAFPFGGPNGWALLRFPPRPSKAKRISEGKPQKKLSESKGSSGEAGEVEGASGNTENRDLAENDSSDKETDPGDSNETVTHSGLNFELHDIRSFLTITTQEGRPAVPEEAVLCLEELLRRLEDNPTRSPPGKRLMCPKFTRDQVEKCLLDMQSQAWQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKM6</accession>
    <name>A0A2R6NKM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v11253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKM6"/>
    <dbReference type="STRING" id="98765.A0A2R6NKM6"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="98"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR72886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="648" mass="72447" checksum="690603D556B828C9" modified="2018-06-20" version="1">MAEYHYDESGNMAVYFLLTFLLVILVPLTLSSPASFRRKQGKDGCPCQQCVDHRANLQQGFLNPKARRRTIILLVGWTFSAFLAYRVASAKIENKVYNPFEILGISSGTTVKDIKSHYKKLSKKFHPDKVKLGMNDTIEAVQAKFVEITKAYKSLTDETIRENLERYGHPDGRQEVSMGIALPKGIVEGRNRLYVLAAYGVIFGAMLPALVGRWWFGNREKTKDGVNARSAAAFFKSLTEESGIDEVVGTLGKSFEWERSQLKSKAAELDELESRIKAKLGSKWATLKQFAEVGKEQYETRRRAFILLYAHLLRLSISSSSLRAEQSNILLQTPTLLNSLLNISISRNWLVPTLAVMRLHAYLAQALIPGESSLRYAQLPGISESEAEVLSRETNALQDLVQTLEEKGDGRVGEIKKAVSKWGKLEIVDASFKVIGERIVTPLSIVYLVVKLRISPPTAEVSAKPVGAPKNGNDEEFLISRKDAEDMPEGAHDGGWAHAPHWPANRKPGWWIVLADPKSLRVIVPPMKVTDVPIADPSSSRDYRSYKLQFQAPQNVQSFPWRLHLVSDTFVEEEATQDITLTISQPEQEQEAEDEISDPEEDSLAGQMAMMRGGTVKKRQDGDDESDDESSTDDDRKENEDSSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKX1</accession>
    <name>A0A2R6NKX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKX1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10009" checksum="3590C08DA8B4B945" modified="2018-06-20" version="1">MNLAFVVSSYRGSRPAARGNYQCVGEKASLWKEGSGGPPPPPTPDLPPHGCIHVYTISVEETWAAKWAPQPSAQSEATAGRMVFRPKLLDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKX8</accession>
    <name>A0A2R6NKX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKX8"/>
    <dbReference type="STRING" id="98765.A0A2R6NKX8"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="238" mass="26971" checksum="BD85B06F619A26EF" modified="2018-06-20" version="1">MSFVTKVPLSALPLPPHSLVLTKILIPDPHTPSPSEFRKLQLEKPSQQRRARILAPESHFSYVAPFPVPFPFRIEPKEGEEVIDKAALIERWLTEREAVHERSESTIHLKKYYPENRDQHLELVGLSETGLQDCVPHLHVGDAFDVLGSPTLSRSFEDEPDRPESRNEDVAARQELIEILSGHATLMNITEDPEKSWAPWSLRYSGHQFGVWAGQLGDGRAISVREWAIATLSSYWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKY2</accession>
    <name>A0A2R6NKY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKY2"/>
    <dbReference type="STRING" id="98765.A0A2R6NKY2"/>
    <dbReference type="OrthoDB" id="3364069at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="466" mass="52139" checksum="8060B28A34B36784" modified="2018-06-20" version="1">MSWTKRQSTAERPHGELQDEDVGTQPLLTNSGDVRTESYGSVDTGSSSLERPSRRHSPEMHRRESLLNRVPEEQSTEGVLAESPEDAEEIQWDLEEQGFYAGSYRRTVMMYTFVPLISLLLLAFLARCPDMFWPIPNAKPIPHPSYFPSPIPELLLSSALWSLGYLLRMPIYTVVSFLTRRLSPFVTTFVFHLIYAIVYNLLRISSSPILRLRTLMDHPRPVWTDPVFRTVWWLSLGWAAIDVAVGIIQSYSQIALYRNVMVPEDRIAQILAQAYGSRTDLISQSEEILPLSPRCEGNSNGSFQPPASWGVSDDTRAQPQKASYSKPLSADEAIGLAVDQDLEQLANLKERQDLEEIYGFPVIKIPVFVSCLQRIDSILLSTGNTLVLSAAYLHSSLSFSPSSSASFNNRPILITFPLVLLINWVLSVMHTPLILPRIGVQTTAYIGLLFGLGSFFAGLGYWGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL67</accession>
    <name>A0A2R6NL67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR72998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL67"/>
    <dbReference type="STRING" id="98765.A0A2R6NL67"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="1">
        <location>
            <begin position="97"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="34070" checksum="9867227D1752FE04" modified="2018-06-20" version="1">MSHPPPTEHGSAALDLAHYFSPATHWDSPWYLTQDLPPPIANNRPPSFSSAWEMRGPSKTVFGGAIFADLSMCWYSVQFPTTAKSDPNDSRTVHRKAQYFPCPAARDQATLVEAHETYGETIAAFAESFEGTGQYCARGECWDLASEALKYFDQYDYVPKPIPSLSRTHGHLIYEGKAVKNGLQQCGRWRGGDDRIRRGDIAEWRSVRIGMGKTGGYAILGAPDHTAVIVSDCVPSTHVYDGGPVKPSQLGLLEVIEQSVGSPPKRQTYDLNQFQEGEMWIYRPIGMLDYVGSLLEPRCPENVGALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLD5</accession>
    <name>A0A2R6NLD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v11080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001116">
        <property type="protein sequence ID" value="PSR73058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLD5"/>
    <dbReference type="STRING" id="98765.A0A2R6NLD5"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR73058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="255" mass="27866" checksum="30D0A86199E883A9" modified="2018-06-20" version="1">MVSLLVKEKVIQSVSERSTPCLIPLQIYVNEVVLGTAFGVIMGPHCANVFDPRHWGSHTNVITLEVMRVVLATGLFAIGVELPPAYLGHHIKGLLVMIIPTMAFGWVIVAGGRFAIRHVPENLRHILAAESAANDGLAYPFLSLAIYLTVESSRGVAIGKWLVIGCLYGLSIPFFSFGRSIRSRTVSWTSRNGSGPDWLLGVLHIPGTHKVPSSTGEELQRDLEKGGEEWKNEGEPRPEVIHLHPPVDTCQPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLK4</accession>
    <name>A0A2R6NLK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLK4"/>
    <dbReference type="STRING" id="98765.A0A2R6NLK4"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="177" mass="19677" checksum="392610975AFDB51C" modified="2018-06-20" version="1">MKAALVASQDFQGGHYTTPPYQGIRAFGIVGNAWSSSQAWFRNRHHLENGKYKDFEDFLRAEGENMFLTWDANDMLTLLRTWQLGDISRVSTTNTSLQGDLVGVLGNISAKALIMPCKTDLWFSPDDSALEVAAMKNGIAKLVVIPSNWGHMAGGWANDEDVQFVKEQVKVFFAEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLQ3</accession>
    <name>A0A2R6NLQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal biogenesis factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001095">
        <property type="protein sequence ID" value="PSR73243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NLQ3"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60612" checksum="6D0A329ACAB6B550" modified="2018-06-20" version="1">MFQTLTNYFNAQRPRVARAAGYAGAVYLVGRYVGERLEEVRNRLLHDRMARENLRRRFEQNQQDVSFTIMALLPTLGAHILEGMDVEGVTQELQAQSRASKAPYTEPTPPPPPLEQSSVPSIEIQSAPEQDARSENESVSVVSYPDHDDTGSSSNLGASSQSWVENFSSQQSQLSPETSSVSADESRLNADSPKSSIVGTDISDSIMTSSSAVSYGDTQSAPWTMESSPIASFTRSKAELWKEVKMLTFTRTLTILYSMTLLSLFTHIQLNILGRSKYIQAILQLAEDEVDRERLQDSLSLAALFWNGNLASAEVDGDLQNVEAISEEIERKYLTLSWWILHVGWKDVGERVRRAVEEVFEGVSLKTKLAASDLHRLISDVRRRVEFEVTFEGTERRINFTSTLLPPTSETLQHVLTQGGIPPRLAAVHDPSFLKLLEETRTQLCSGSFELVLEVCLDKATELLFNGLEKNVFGGSTEWDDPNSSLGLTQEPRVRLAGMLPGLARWCHLALQGLPNELVDGLGDTREVKAFSAIIYSNYEDQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMZ2</accession>
    <name>A0A2R6NMZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMZ2"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="27989" checksum="C488120B1E1F64D4" modified="2018-06-20" version="1">MVFDASKYESQIRAILQAPGVDLTLISAKRVRKQLVEDNDELTTELVKDHKEEFDRIIGSVYEQVSEEAGVEDAEEDDATGENGKRKREGSEENQGHGSPSSPKKLKKAPKKESLTDAELARQISSELNGRGRAAKTESKPKAKRTKKAAKSKATVNSEGEAEGDDAEKPKKRRGGFTKEYSLSEPLATLLKVERLSRPQVVKHIWDYIKEKQLQNPEDRREIICDDRMKAIFGLDRIGMFTMNKMLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN24</accession>
    <name>A0A2R6NN24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN24"/>
    <dbReference type="STRING" id="98765.A0A2R6NN24"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="718" mass="77605" checksum="42F8DB5B33EC15DA" modified="2018-06-20" version="1">MSPLAAGQQATSYMTAHVVESPGPSPIIPHAQFTASLPASPLSSPRILNAKAHEFKPIPRPLSAAASSNPNSLSSLRAETPSPDMWAHSQRPTSKLAIAAPLTPEGALLPRSVTPSSLRLSLRPGEEEEEEDPFDPFAPKSIQRSFHPVESEGHPLWSNSPLSNSSLSTDDPQYNYYTNEEHYAQSFSSQSLQSQDSGDFDPDANPMLTDGMTPLDVLSMVFGSTLAPSELEDALSNNGYDFDRAMSWLVDRQIATHHSSALMPAQPKIQPVGNRVTIVSRDGHGGYVRGGRAGYNHMGGPSRGRGFLGRPVPGGNRVCRYFLAGECLRADCRFSHDLERALCRFWLRGTCAKGESCEFLHHLPKDVDVASISQTMSRADISPGGIENVGPSPTEDFPALNQTAAAQSKGRRGGYGRGDGGANDGRTRFAAAVKKAPPPPPPSQLLKESAALATRREAMSANIEPLTNNTAIVAPKPSPRLKLRPPTLLPTLPTGEAVNNLYMAYRSRAHQLASDRNRCLTRAAEAWKRGDGALAKRFSREGHDLNARMSAEMGQAASKLVRERAKLAEQVVREREANWSDDYGDRAARGKTCGAGLGVCLGIASQVVSDGKKLSPEERTEAMLDLHGLHSTEATEVVEEFLLALEREHFHGLAPSNSVYLPPAYLVVGEEKHTGTADVARGASRARLATGIREWLHLWGYAWSERDGVICVDPLTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNC8</accession>
    <name>A0A2R6NNC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNC8"/>
    <dbReference type="STRING" id="98765.A0A2R6NNC8"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="38833" checksum="300CB6DC66DBCFDE" modified="2018-06-20" version="1">MPETPRHPPAYHGRPWYYPESMKHCYSRTSSNGGARPIPYVCPSPRRSRTAASFEPSDARRDRDQEPWRHMAKTYAWVMEQKIEEMARQNEETVRWVLKQQERDIRERAKLVVRQAEGRYWDLMEEIHEVVDEEIHHHLPRQDRYWTRQSSFQEELDMALQEELRKLQSRRRETERCRAAYERRKALEEHREKERRKQKQDKMKVERDEAERAAWKSYEAKWSSLASGDEAADPLTFETVPWPLITPPRSVEDLRPARIAMFLLSPQHSEEQTRKDRIRNALRRWHPDRFGRILAKVRDEDKEKVAEGAGIVARCLNNLLERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNJ2</accession>
    <name>A0A2R6NNJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001052">
        <property type="protein sequence ID" value="PSR73879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNJ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NNJ2"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015336094" evidence="5">
        <location>
            <begin position="23"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="448" mass="48248" checksum="725CF53FDB6780DA" modified="2018-06-20" version="1">MYESRILMLVVVTYTLTGPVYALDWCKSAAPGQQLRARSSFRLGIGSLTDNHQNRIAVVGLQDERVLVEDDFAENYPDFITLAEANHGYPATSLQWQPAASQSFAWSQKAATSELLATTGDALRIWEYTNDAPTGLSSYVGRQSGGTGHRLSVKAALAGNAWRRINGTTELTAIAQQSKVQNHQTGAPLTNFSWNEKSPSLVVTSSIDTTCTVWNIDTSTAITQLIAHDREVYDVAWLPGSTDIFVSVGADGSLRAFDLRSLEHSTILYETPAPKNAPPPSASPSTSARPHTSPLLRIAFNPADSNYMATFHQDGQDVQILDMRSPGQPVMELRAHRGPVNALGWGSTESPLLATAGDDCQLLLWDLSAYTSLPAASPRHAGSGLSSPRPDAKKKVVTDPVMAYTGPSEIVNMAWSPQMAGMTINTGHSTPGEWLAVAMGKTIKALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNZ7</accession>
    <name>A0A2R6NNZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNZ7"/>
    <dbReference type="STRING" id="98765.A0A2R6NNZ7"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="3">
        <location>
            <begin position="261"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="499" mass="56377" checksum="D4BA006B77A579B1" modified="2018-06-20" version="1">MALVIPANSYHPVTITAQVLEAGILMVRGCIVQAPGGAPREFVLPVSSEDEESKRSRRRSAIENEAGRSKHAGLDSRLWKKQEKRYSKANTPAQPTPIRFLECKVVSEQPFLRIRRTSLTHGALMLYNGEKSSIRITLENTSSLPIDFMRLTFDDSTVAPAQQALADGGLSVFDTYETEYDLIHKPVFTWDSKASKQEIGPGEKTVVTVNCFGKVGCASGVVHVSYSYFHRPRTTLDQPSDIFHTRQLSYPVLVTVYHMLECHAMDILPYSPDSTFATIRDSQGFDSDTTTTKIGLIVDDITDWCIFSIEVRNTYGLPFEVTFERQQAGAQIRMIAVNWLTTCADTEPCLMTSVVPPGSMSRVLIPVQKFHLAEEHISRPIPTLSDRQFILTKSNLTSAEERTQQELFWYREELLKLVRGRWKESGGTRTGDLSLRNQRMTQRMVEVLRTEIARIQLSLWHYKDDGSEPSLVPCSGDIYTPPLNDFVYLRAKVMNLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPD1</accession>
    <name>A0A2R6NPD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000995">
        <property type="protein sequence ID" value="PSR74342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPD1"/>
    <dbReference type="STRING" id="98765.A0A2R6NPD1"/>
    <dbReference type="OrthoDB" id="3270296at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="604" mass="67509" checksum="A4982D94B69D7E72" modified="2018-06-20" version="1">MPTTRLRTRPTKSASASLASKATRKALHAVDTNTASYDRTDPFTALNVLRKLIASLPARLGGCQFKLSPEEHRLSMHLLTIVEPFVGASHSRRTLTRQPTELLDAIVFHLDSKSDLLSLALSCKRMHGVIFPRHYHYRTIRAKVSSLSVWNHLVVHRSLARNVRVLEILDERTTEPELLPPDILTTDTDLESSDDELSMHVKQERFLVSALARMTALESFTWSCNHSPICIDCVWPSLLKCQSLNHVDINDNLIFTDIDTVEKTPAKRQTLLPEVRTVALKSTKHVYGSTKTPTLARVSAMLHNCPNLEDLSIGYGQRRGGDFMSPIVDDLFMFGRWPQLRLLSLTQLWCTPHAGPDITATFLSAHVNLQVLHLDMSTTLGAAGAQISLPPDSLPHLRELKSSRDFASAVLQCPCSVEGGRPLEIIKGVKLSGSGWDDKFFRSLAQFGSNVVKRIELAGWSDVEDLRRLIECIPKLVWLDIGTRTNNSNSMAYCSDVIQANTNRNASSLQTSVLEWATLLASLTGLAAFHGVRFFYEVTSTNPAGPITISERSKLRKNEEIASILAWKCPKLRRLDHWEDGSGKVVVLLRDGDQVKYEVRRMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPM0</accession>
    <name>A0A2R6NPM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPM0"/>
    <dbReference type="STRING" id="98765.A0A2R6NPM0"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="302"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115303" checksum="DCD06612BB5BF9A1" modified="2018-06-20" version="1">MTMSTPALSSSSSSVGSPSPSYRSQDDVNKAEAENLAFDDSDALQILLQTITQSMDSPPVNNPDDWSQLASWTSQDSKAVDMASDFNFAFPMDLDFDPNMAVDPSALHFNTSIFTQPTLSDHGYLMGMHEQPTSELLSTSVFPYGSNAWAPHIEPATGRRLSITSSSSSSGASFSPILEPQSAVSSSPSSEYGLSDSDPASELAQRVRQAAGVTLAVPVSAQVQQLAAAGGQLKLPIPRLPRPTLSPALVKRSGSSKSVSPAPELTPAASPTASSLSSESSESASVTQSHDPNAPTTTVIGRPKTSHTTIERRYRTNLNARITGLKQAVPALRVLEQKNGQSPYGDIVDSRGFVDGVKVARKMSKANVLGKATEYIRVLKKREARLKHEQGGLKSLVGGLVGGPALLKEWEREWRDRFGGEERDEVEGEDVATASDDEDGDGEDSDGEDEDGRARKKVKIAKAPKKEKALPKPAPPLPVSAVPGAAPEKRKRGRPRKVPLPTPVAPAPAPAAMQQTGAGPIVPPVQPIEHSLPMQHEYFNQPTNTQPTGQYLLAAFAFFSVFNSPLASSYTRTHNHAYSQGHAHHGAVLTAHPTMVPTSTVTPSHNYGLHELVQAFHLLVSTLVFFYVVLPWISGVVKHSGVPSILLAKLHSTFSTAHHQAPATPTILEAKTYQRVALTNALSFSVRGSSDEPAQLRTALGVSTGVFGLMQGVIKAARIDRGLEMNQLEQRAWVRLGELVAFDGAAPRITRLQTYWCMSWHVSTFATSTSDLATLALIILPVSHSKASELWDRARNQEILRPYEKIALTNMTIDDAAEWLAKWRRWHNTERKGRCAACEKRSPLGILAAIITRERLRNHAAAMFVRTVVPSQFREPREDCSDCEGDELVYDPDQDEKDDQDRRETIEAGKAIGGRTAELAILLERIWDTGFCAHEDVISTSRAHYSSYEDGNCENEHDLASTDEAEIRSLLSATMIYRRIFPSSFPSCATAVSVILSPPPSPSRKNMALHVSLRAALASSAFDLADGRLEDGRLGAALDNARDRVNDMLTALERSVKRNTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ20</accession>
    <name>A0A2R6NQ20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v9681</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ20"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ20"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR74615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="359" mass="40636" checksum="196F34C149487179" modified="2018-06-20" version="1">MKSDTGEVFLSDTWADQDIHYPDDSWNDSGKNLYGNFKAIYKLKKRNRHLKVLLSIGGWTYSPTFHPIVVSPQLRAKFVASAIRLLEDNGLDGLDVDYEYPSDEVQARGYVELLKELRHGLDEHARKKGTDYRFLLTIAAPCGPDNYKKLFVREMDRYLDFWNMMAYDFSGSWDKIANHQANVNGGPISASEAIHWYIAQGVSRDKVIMGVPLYGRSFLSTDGPGTPFQGIGPGSWEAGVYDYRTLPLPKSYVLRDEHALASWTYNYQTKEMVSFDSEEVGRWKGEWIRNEGLGGSMFWELSGDKGSSRKDMEGGPGKDAQPGRSLVAVVKEAMGTLDRTPNWLQYEGSQFDNMKNGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ33</accession>
    <name>A0A2R6NQ33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000973">
        <property type="protein sequence ID" value="PSR74647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ33"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ33"/>
    <dbReference type="OrthoDB" id="2756261at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="338" mass="37912" checksum="BF1B677A6F66BD0D" modified="2018-06-20" version="1">MSSNGDTNNTGSSDWMSKYLTASATPYSQSGPPNPDGSSISGPPVITPVFNMQDNVFAIPPSPVNSSSQESHTSGEGGRVNSGETHWNFLSSPLAPTSTLGIRAKRDKDSIDAICPPQPEIYRKMPGQHARAFASQHAAAQGLTAEQTQAVLDFCEFKFTEMMIAMQVAMFKHENMMAQWMLRLYVRHPDFQDHFQDNLDSLGLPPSTKDDPVDWQMFRTSVSDELAVQRSWMKNKQGAIVEFNRTKKQGQTGKHWEYIDERIAEMRAIMKQYPPAQRKMHEAAFFAKVLAEDQILYPPSSGALMRQTYDNEAGHDWQRSMEVVVSNFVVDNDEVMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQB3</accession>
    <name>A0A2R6NQB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000968">
        <property type="protein sequence ID" value="PSR74675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQB3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="82" mass="8939" checksum="FFC3BB379787BC9E" modified="2018-06-20" version="1">MIFSEATERCKAVMGVAEGSDGSSDDDAFESCALPDRFVHSPSHPTRHTHGPDLAHGVYASSRLARQYRRQVVERVPTPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQT5</accession>
    <name>A0A2R6NQT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQT5"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28797" checksum="95171BC1AF3A9D05" modified="2018-06-20" version="1">MAKQRTQALTERDKEKEGKKPVMKPVEDVVPSEPKKDEDTDLSDLEGRIQVRIVSKSYLVQDVEYVILETLLLSPDPPDRDRARDTLASLLTRRRGEYIFRIGSRPLNAKLFAGEVITASDGTHGIPRTLEEIETLCSRIDEVVDEFGGKVSLSHAIVGSILKERTNFARKTSVLYRVDEPLPHAALLLRLPAPSVALTPEVRCAVVGNVDSGKSTTLGVLTRGLFPLQELSYCIMIQLGFSPRCVGRWTRSSTSQLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR67</accession>
    <name>A0A2R6NR67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000924">
        <property type="protein sequence ID" value="PSR75146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR67"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5047550965" description="Hydrophobin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="111" mass="11334" checksum="C2EA5859AB9A5D96" modified="2018-06-20" version="1">MFSPTAAIFFVLVTLPLTALASPAILARASDCNTGPVQCCDSVQPANSPQVLDMFKSLNLDIPINAPVGLNCSPLNVLGGGVSGSCKANPVCCENNQMNGLINTGCVPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRC3</accession>
    <name>A0A2R6NRC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000910">
        <property type="protein sequence ID" value="PSR75264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRC3"/>
    <dbReference type="OrthoDB" id="1161823at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="19701" checksum="4F2A3921B409A3CF" modified="2018-06-20" version="1">MSFPFKPNTEPPKDMTVFKNLVKVASDSDKFRRVLWTGRNSQLVIMTIPVGGEIGEEIHTVDQHLTFHSGSADAIVNDKTERVGPGDIVIVPAGAKHNVSIIKLIFYQWSYPYLYTSVQFTNKGQTPLILSTVYAPAEHKADTVHSSLEEGERLEDEGKDEPPKWAQDLHQKDIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRG0</accession>
    <name>A0A2R6NRG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000908">
        <property type="protein sequence ID" value="PSR75290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRG0"/>
    <dbReference type="STRING" id="98765.A0A2R6NRG0"/>
    <dbReference type="OrthoDB" id="2793484at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015311900" evidence="1">
        <location>
            <begin position="20"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="2">
        <location>
            <begin position="72"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="3">
        <location>
            <begin position="238"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="634" mass="67869" checksum="5328E570C353E760" modified="2018-06-20" version="1">MLSTLAIVALLSAIPTLTATSLAGRTLVPAKRAITLETRDLWRRHIVPKESVQLNYAISTYHPPSASVSFTAHDGRPLLLLEDLDHLLENVLCCPLVPDEETSIMKIRFHSSEAFTEALGHWGHLAEFTVITAHPSCNIDNEHGAWTVVSTDGDFSLKVLMLTVRSIPMNAVGRSCRVKYEHSGSNKWDARDLTTTGIIHRRDEHSNDQLYSFGYSPDLSSPFPLFPPPNATLISDAIQTQLQDVNIQLSCINCVSQTNLSIGVDFDIDLGDASCFISSTENCFTLNRAAMNFTVQDFEQSADLELVIGGQYSLSTDFDVLKIPIEPAFTFGSFIDIGPAFGLAVGFDLDIPASLNVSYGAKAQVPSGAFASVSFINETGGWDPSVDATGWDATNVVQVPFRVNSGEFNVSTSVSMAAFVEVAFTIMGVGASARVTQNVPAVNINAVVHNAVNRACKPIGADDFESFGTAFAVGAGLELGSTAHFEVDTGEFFGTLIPADWDFPIWSHEIPLAPAQGINTTVCFVLSDDATVTTGNAKVDAVTLAGVPAATGTMFPAASAVPTWDIPKIESYYSANGHLPTNVNYNQMAQATTIPDNLQTAIAKAAKSGTKGKLRGASRLCIVLVAISFGSWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRG6</accession>
    <name>A0A2R6NRG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRG6"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="208" mass="23889" checksum="9460E7A36404D847" modified="2018-06-20" version="1">MASGNAAQLYFCNDISSMDEWAKRTGIPLTTADALGTPYRRARDWIVRIRNELVGTHGWRDVVPLDSRILFDIEMPYPYRSEGGIPLRPNLRLRLPAHASTFFDPERRVQWEMVFHSNIFHLLRHTVRPITDLLYLLQCLLTGMLVLVMEDLPGQGGLRTIRALPPSDWVAAHEPELVKIFGHTHFRLLLRAAQDTRVAFKVEAAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS24</accession>
    <name>A0A2R6NS24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thg1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS24"/>
    <dbReference type="STRING" id="98765.A0A2R6NS24"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thg1 C-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="14452" checksum="C694AFF9A9770ED7" modified="2018-06-20" version="1">MTTQASLNATETQLTAHINNLYNTVFWALVQQAGETTTQAHAILRGTVSKQKHEILFSRFGLNYNGIGERYRKGSILVREEKVRNKVRKNLFRQMRACMNGALKKVAGERGRKRGRSHRKQRSAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS75</accession>
    <name>A0A2R6NS75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS75"/>
    <dbReference type="STRING" id="98765.A0A2R6NS75"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14908" checksum="310CED1573DA0E99" modified="2018-06-20" version="1">MEGMCTISGFSTAKSTQMHWYLLSSINYYHLADLSIPALYNVQGKTAVITGGGSGIGAMFASAYVQNGAKVYIASRKEKQLKEVSEALNKIGPGSCHYVVADLSSKAGCDALADNIKQKESKIHILVNNSGATWGAPFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSX1</accession>
    <name>A0A2R6NSX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSX1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="8300" checksum="CE5FD0CCDBC4BE73" modified="2018-06-20" version="1">MSRSNANVHLRIWARDDVVGPRLPKFVQPIPKSPVRDYFFDGVITTCPDYRNPLYYLTPQLARCKMKWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSZ3</accession>
    <name>A0A2R6NSZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000861">
        <property type="protein sequence ID" value="PSR76110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSZ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NSZ3"/>
    <dbReference type="OrthoDB" id="7108654at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF32">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24934" checksum="BE7297C729486D08" modified="2018-06-20" version="1">MEVVDLSQVLWSDMPVYHGDAQFQCTSTFLLPGGITTQYIGCSSHHGTHIDAPYHFFEDGETVEQLPLSDFIGPVIVVDVTDKAPRQRIMWSDIEHYEERIRLGASQGALVFFRTGWSKYWLSQEYSGHPFLDKGIAEKLIEFGIQAMGIDTFSPDETPVYDLGGTTKDYGVHQTFLGAGAIIAENLTNLEAIQDGDWTVCLAPLKILGCDASPVRAMAWKRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT48</accession>
    <name>A0A2R6NT48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT48"/>
    <dbReference type="STRING" id="98765.A0A2R6NT48"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="124" mass="13074" checksum="5A12247533EDE2FA" modified="2018-06-20" version="1">MFVLAVLGTVLHVWHSRERHVLRLAGAPGTIASAVSLGAQTGVGNVLAGRQGVEDMSQALANKRFRIDTRTMKIVMEGEEGYEDAHSPLNKEGFGLGAGMVRRLSTGWMLASRQGGGKASTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTK2</accession>
    <name>A0A2R6NTK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11631</name>
        <name evidence="2" type="ORF">PHLCEN_2v8696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001164">
        <property type="protein sequence ID" value="PSR72497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTK2"/>
    <dbReference type="OrthoDB" id="3160134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="6000" checksum="4E4BFFF6E692D20D" modified="2018-06-20" version="1" fragment="single">TRFFCSSLVSWREKDGAFSFKQFYYYIVALFEMDLDSAWVAETLDWWDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTP5</accession>
    <name>A0A2R6NTP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTP5"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="19378" checksum="3ABC41A37A800334" modified="2018-06-20" version="1">MPSLVNQGRVQGDQPPIDMDWLYPDPNTNLVINLMVVPANAGDSRLNHWELFWVVRGTPGDSKALRKISLEEARDGTHKRLNHLTYWGAVTKQISSTSRVHTAYKIPVGFINLDSRIRLEEIARETQVMSPYDNGRLWNCQDFTTAVLYKAVECGLFRREAVDAALHSASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTZ5</accession>
    <name>A0A2R6NTZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTZ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NTZ5"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF1">
        <property type="entry name" value="OS04G0684500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="74543" checksum="882157CFDB0B4DF6" modified="2018-06-20" version="1">MAALRNIPYPSSGLDTSIFEDSLDEYDITLNRNDSSLSRKPCHLLRSLIGERKYADAARAKGEMEELGITIEPHAIYQTAAMYALVKAPFKTKEERMAAFISWWSLVPDTSQKHYYYPRTSPIMSALLERTAIPNISLIMQYAIAAAGKGLEGRVSKVIIPIVLRHSPPSISLIFLDKYRKSDLAYRLARIPRRDVRATAACNFQNRKHFRGWYALAIRTHCMAGRYSAAVATLKAARRSNLTIPEATYNFILGYLRRGEHPAVSLVEDIWQEQRTLKPKTPSPPPPLSATRYELPQEIDEPKSPHLITVYSRLLETLAEGGIPAHSRFRHFLALCGMTGEWQLLQNIREKVYIHPRFATVASSMIYAEMLHHSEGGDQDAALMSFAEHCHTIGIPKIALLKIRQLRMEKQNVTEKSLPTPTTLPKPALKHKLWPSSYQSTIVWRIIVQDVLKSDGHVAENLKKLYNELLSQVTLSRAPVSMEAELENIQVGALAQTSHSSSGEGGAEWKIEGSPASIPVQPAPSQYTAAHFNIFIHAFVAADMPRRAANIPADMYRVGIAPTLHGLTTIVKGLASIGNVDRVNALLDIMEASAKPQDESLGSSPGSNMTLPPPTVVTYTAALQGFKRSKCKGAAVGILQRMRTNLDYTPGPDPYLDSAVAWLNEEIANDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUM8</accession>
    <name>A0A2R6NUM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000818">
        <property type="protein sequence ID" value="PSR77010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUM8"/>
    <dbReference type="STRING" id="98765.A0A2R6NUM8"/>
    <dbReference type="OrthoDB" id="3271139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015312828" description="Protein kinase domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="96"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64767" checksum="3878BA075A0D82CE" modified="2018-06-20" version="1">MAGSAHMTEPRILFLTHICVCAAPLVAHWGGWTSQHLANLKKDAQPLTGKQSDELGWDPTVRLLKDDQQTPQYDITVRTEDGEKLVYRTLELISDLAVESAIGKGTRVWKVIRLRNGEPFGEPAVLKDSWVDKDRPREGTICQELRSFAGPVEPPPGLADALLTVECYGDVFIEPGPDLIYLDHTIQLPTTQPPNCGISPPPVWSVGRYKIHHRIVFKEICTPMMNSSAFQNVFRVLGQACLALQALHTAGWVHRDISSANILIDNTGRAKLIDLEYAKKVDEECAKEMRVGTAKFMAAELILRRYQYRRMRTPELMAHLPPKRNREEDYRLLFDTQSLPPIESPPPAPRLPSPKPKPPFRYNAIHDFESLWWLTTYYVFKMEAVVDRTSTSLPKPQLKNLEQQRAHADKLSYDRSWRDVVMLNTDAFIESVHALDPSVRPFGMIMEQWRKKILRAYYQAEETLIPDAKSAMQGLYSEFAKDLVWISDALASKTVMIEETWTNEEPVVVTVAKETSKRKREDDEDKSEQKAEEPADSPRSRKRARNTCPPHMVDGPAARTRARLKAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUS3</accession>
    <name>A0A2R6NUS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000812">
        <property type="protein sequence ID" value="PSR77132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUS3"/>
    <dbReference type="STRING" id="98765.A0A2R6NUS3"/>
    <dbReference type="OrthoDB" id="2733714at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF9">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="540" mass="60840" checksum="2E90B0CD51C069CF" modified="2018-06-20" version="1">MNATQPNFLAWESEPTRRGTYNIISTCLITLVFCVWSSVHIDIVQSQRNAFIHKLFALMLGLLAPEVLLATAFLQRNFATQVMNEVNKHFTIPAQMPWYRRVPTQLWTKVRTYIWSTKASDSESYSQFHPDSEKGTSTRVRWTLVHGFYAVMGGFVFDASTEPKFLPNSYTRAILTPAGLRVLLEHDPELIPDLSEAEIMDKSKADGLAKALLLFQALWFCTNCVSRLAQGLPLSLLEVTTFAHAFCTFFTYLLWWHKPLNIREPTLISGERAREVCAYMWMASRIKQYRFGGLFNSSSASEFSIVLTDDGDILMDDGNIAGEVLPHNAEDIYLRIWGRRPSSPFAAAYSVKKAFKSTSGAWYSRQWDKPFENVSLTSGDTERWALASKALSRYGPPSQYLNSLVHGENEIEGEWDIDSKAGLMITVALLTAIYGAPHVAAWDAPFATRSERVLWRSAAVVITTTGTAFGLMVPWLNIRDIDPNMINSKAIILGPLILGLICIYPVSAVYLLVESFKQLSHLPPETYQLPSWSNYFPHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUZ2</accession>
    <name>A0A2R6NUZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NUZ2"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="196"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR76796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="498" mass="54250" checksum="F1DAC4294745C0A4" modified="2018-06-20" version="1">MEAARRRRPAPRPTSVSRAGSVRSRNSIYKSADTQASDSDSDKNTTEGLSHSLAKSLSLRKSDSNGGKPPSRPPSRPPSRPQSRASRKRSDSTVTAVSASEETEKEKVEKEKEKSRRRSVTGWASSKIGSITGRGKKERGKFDSLMADRDDQVSDDDEDLGGPPSRQSPTKMRKTKSASATPNASPQVPPRPFKMQDRKLVVALHDFAAGSSDELTFKAGDQIVVLNEVLDNWWMGELSGKTGLFPTTYTEVLNSSSSSLLSKPPLPRRPNSTTQLPILIPKPSVAPPEEQRKTAPRWLTHHLDEPVTSDEEHPFGDNYVADSRRPLDSHFYPESIASSGDEYDENERLVPVRGQDGDADFGPVSVSSSSTSRVPPLPVRKPNLPSKKPPPPPPPPRRPANSAPTTSGMSIQPMIPARPGTTRTNSSLHSHSASSSQRGSTSSFPTLAMASVTPEPSDDLTFSPFDSPKDAVFYRGCHNFRQDPTKIQGVCANCFQMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVH9</accession>
    <name>A0A2R6NVH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVH9"/>
    <dbReference type="STRING" id="98765.A0A2R6NVH9"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="496"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="538"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="578"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="654"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="793" mass="87579" checksum="E4FCE5EA33D6F57A" modified="2018-06-20" version="1">MQEDEQVVSGKGWRMIKPDEASDTRKEVGLTEAIERYGRKRSYSVENMMEGIEATTGSTTNAPPRKKVKPAPPPPISTTVMSAAPPSPLPSPNGSPPPENIWPSAPPSGHSSPQPHAPVQPDLSLATLLTLPSLLAHFSNLPPQLQSHVLLTFLRHSPLPVLRTLHSVLTPTLARDFLSLLPAELVSLILSYLSFADLARASRVSKTWRAIIDSDPVLWRELLKTTKIWFGGNTENAFADAIFARRRRLGTPLSSSLPLPHPYKMLFKSRHLTRTRWVQNQNPKRITFPAHGRSVVTCLIFSHGRIISASDDHSIHVYCPVTGTLVRSLDGHDGGVWALAATKNTLVSGSTDRTVRIWDLSTGRCTHVFGGHTSTVRCLAIVKPEWIDVQNENGTTTREKWPKRPLIVTGSRDHSLRVWTLPRPGDDEYRCYSADDTEVDPSEDEVDDNPYHRVHLEGHDHAVRALAARGRTMISGSYDCTVRVWDIINGACKWVLVGHTQKVYSVVLDIYRGLACSGSMDGTVRVWDLNTGACSHMLQGHTSLVGLLGLSPSHLVSAAADSTLRIWDPETGELQHTLAAHNGAITCFQHDEFKVLSGSDGTLKMWDIRDGTQVRDLLTGIVGVWQVIFEGRWCIAASNRTDSTVLDVWDFGGEDGDEEWVGEPPGGLYDEDTDDEDEFDVNEGELGVDPMDQDVEVSPSDLDEAFAEDPDVAEDEEDRLGEWEAPSKLPIPTQPATRSLGSRLESHRPVRGRLLLAPADASSSSTSTRSRPLPTNDETPTRPRIRNMIPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVL3</accession>
    <name>A0A2R6NVL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVL3"/>
    <dbReference type="STRING" id="98765.A0A2R6NVL3"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="370" mass="41584" checksum="9AF3052F15DE44C5" modified="2018-06-20" version="1">MNTVMCIGTPHGSLRECSNNPASLTSRLGATIDVEQNHVRFLGDLILNLWDCGGQDAFMDSYLSTQQSTIFQHVGVLIYVFEVESRSVVRDLEYYAECLYALKKYSPEAAVFLLVHKMDLVRAPKEAVLERKTMELKQASGDAEITVFGTSIYDETLYKAWSSIVHTLIPNASVLTRHLTKLADACSATEVILFERTTFLVIATSSHPPSPSSPSPLELPPSSPPTASTPSTLSSFGTHTSRLSAKTDDGDPHRLDPKRYERTSELIKAFKHSCARVRDEFHALEMELADFTAVLDELTKNTYVLIVRRHDRKGLVLWIVCYTKHLGRKQNRYQAQGTLYRADNWWGQEIDNWGGRGNAAGRERQGRRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWN7</accession>
    <name>A0A2R6NWN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWN7"/>
    <dbReference type="STRING" id="98765.A0A2R6NWN7"/>
    <dbReference type="OrthoDB" id="3358294at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044784">
        <property type="entry name" value="At1g01640-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47274">
        <property type="entry name" value="BTB/POZ DOMAIN CONTAINING PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="151"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="512"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="880" mass="99244" checksum="F6C19DA3AECCAA0A" modified="2018-06-20" version="1">MSTNVVFGTWSAASTNDNNVDLEAQVVVGRYESSPSTVPYVYGPPPARTYSPRAQSAASQGTDPVDDFFGVTRSTSRGTQDSRHDDRRVSIHLDEEIAPPPYADSNDLPSYASVAEPPTLAMYLFKFGFLSSSVRKGDIIVASEPFDRQAADVILRTSDNVHFYVYKTVLLASSTFFKTIFSSCTWKADRYHGYHPIIDVPEDSSTLEYLLRFCYPGHSPMITNPVKLDLLLEAAFKYDISTAVEPLHEALQLSVYQNPLRVFAIACRHKLEDEADLAALTWKKQSFLDDTAQDFSRTCAGASYVPEMAQTSAGAYYRLLSYLRTARGNARFQLHESCPSETSPPTAEFPQPRSDPSPSHSPFNRADADVVLRSSDNLAAATCGWIEEARVALELLVFEPIHELYVTELEGVSADIYHRLLKQHHLLQFTLLNTLEPPVRYSNRSDTPSAANVPWKDTWLTVYDGISDTEVGRRRDSHLMDMVKRRREIQVILRDAMQGRVTAAAPFDRQAADVILRTSDNVDFYVYKIILTLSSTFFDTMFSLQQSPMVEALPEQRPVIEVSEDSRTLEYLLRFCYPGRDPVIIDLGQLDLVLEAALKYEVGFVSELLRSQTLQTFISKNSLQVFTIAVRHSLEDTAKMAAVRCATNSFDENPLDFTNTIAGGNYVPEMERIPAGAYYRLLSYLRSPNANRNPKFIHNRFCEPPPPSTEGPEGPQALSHFSPFNRAEATDYGMTSVVDTMRSILKRAVDSQPFRVYLIAVACNWTEEARSALELLASAPICKLYATELEDTSADIYHRLLKQHHQIQVAMTKVTNGQWKKHWTRPSYGKSTRTVPSVLLVKRCRGNSDYRYELLDIMEQRHKLEITLQEVISNVIFDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWR0</accession>
    <name>A0A2R6NWR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWR0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="190" mass="21321" checksum="DD3FF477548BCC65" modified="2018-06-20" version="1">MNQVTYWQAAAQTYQVQPQVTPTIPIYFQNGQGLPFNVKTIVSMVEDMGPELVGFMEPVLLNAVGSQTIDVHILVSVPPSTLNMQTPIIPTPISLTPKCAGTTLHEKVISNISTHGGRISKGRLLRSLADALKYNRFKKSEARAQQDKYGSGVSEEIVNKVRILALRYQHINCRWGQHIECRWELVCQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY02</accession>
    <name>A0A2R6NY02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY02"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5617" checksum="8A3A00AE35F46A29" modified="2018-06-20" version="1">MLEVCTFQRQLQTYIGKEHIKSALFLQSLPANPDYRGFVGSICLDRGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYT1</accession>
    <name>A0A2R6NYT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000681">
        <property type="protein sequence ID" value="PSR79848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYT1"/>
    <dbReference type="STRING" id="98765.A0A2R6NYT1"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054000">
        <property type="entry name" value="MLKL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22215">
        <property type="entry name" value="MLKL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="118"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="305"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR79848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="817" mass="88887" checksum="5613D5B46F518268" modified="2018-06-20" version="1">MALKLLSKCRLRVLLLHQCPNSRTAITRLLTSSSSSNSPKDTDAAGAVEETQDVSTMDRLLRTVRDRANPAYQSLLPMKSLTKWSDTLTPTAACTTSPPSFSSSPAHDSRTARHMCDSYCSLTLPFSSSPDLLEAYTNTTGGIRTGKLMEHLDSLAGSIAYKHMLGPEEVAGRMELGGRGFYIVTASVDRLDMLAPLHPVRDMRLSGQVIYVGRSSMEVAVRMEALNLDGTEETIMLGRFCMVARDSETHKACAVNPLVASTAEEEALLKIGKVYAQWRGAAGGGGWGRAGADGGDAVGEDVDDVSSGEKVSVVARGEGVADGPSVHQKIFGGYLMRLAYELGYSNAMLFTRGAVSFLSLDSISFARPVPIGSVLRLKSYVLHTAGSEQHPALVHVGVKANVVEMRTGKEQLTNDFRFTWSREAALRRRVVPLSYQENALSVALATTAVTRELADMCQFPPVRAAAGLLLLIFQTIQVSPPSLLFTALTPAQDIQTNRTECYRLARRSLALLTDLRETMHGRCQDAPPSLLLAIHKFEHTLEEMHTALKASAEHKWHSRLIKKNSIEAAIADFNLQLDDAARSFQIATLINIQYELATSAPLCESPTAAASIALTPNGTSSDDEFVLVSTSDALPAAQSLQQQPRDTTTQQLTEEEAIAQMTKDLKDHGFRRFHTSDLSFTSSSAISTSTTDWWSTARDGVSLRTTTDDANSSYSESVLYMPYHAGTRTAAAQKWLQDVKILQNVHHPNLPQMIGYSGDSAPTPFILLANGKHPPSLLAHLSGVAHIPAFSQCRRGFRKPSSWTRSKTRASSRARGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZD8</accession>
    <name>A0A2R6NZD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZD8"/>
    <dbReference type="OrthoDB" id="5418639at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="373" mass="40468" checksum="38BF7B22522BF387" modified="2018-06-20" version="1">MPTHSFTPKEWEDAIFPHMKDVSTNQASPPVSQSSQATGNSYPSTLPSQDQTSSIMAPPPSMVTPSRKRQRSVSPGGPSMASIPSVKRVAGSYTSPRNSQEKPSVSSIIGGTHQEACPLGSSNNAMPSHLDSSSTQPTSYGHVSDEEWMASSSPDTPRQDQDIGPRVLLASRTASDSSIGPELWSTGVRRPSTPHREEPGGSGNTIAHGILTPPRSTPRTKWHSSAYQIYPQAPATPTRSNGKTRDLLASTASGLQNDQLVPVCWQIAMHVCNGCLHREQRLSFELQHDAFHHRPTPVDKQQAEAVPGWITSPDSIIAHLDALSCVPEHIRKLERKIKALESSVVQRTKAIDELKADKIRQLGGEEQQPGEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZM9</accession>
    <name>A0A2R6NZM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000618">
        <property type="protein sequence ID" value="PSR81449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZM9"/>
    <dbReference type="STRING" id="98765.A0A2R6NZM9"/>
    <dbReference type="OrthoDB" id="4230923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16745" checksum="02256DD321D01F0F" modified="2018-06-20" version="1">MREETKSKQVLLEKVNITGKQLEDQVLLRRANLALEHMGIQADDAPKKCKEIYFASVVVLPRGGVVYEMDSRESADWIKKADVKAAFLEKYGRGLDVEMKDRLYLVVVDSVPIRLNIDDGVALRRIEGGNTIKEGSIKKVRWFKKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZU2</accession>
    <name>A0A2R6NZU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000609">
        <property type="protein sequence ID" value="PSR81714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZU2"/>
    <dbReference type="STRING" id="98765.A0A2R6NZU2"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="245" mass="26301" checksum="B9B9D5957A2BC8B4" modified="2018-06-20" version="1">MPGHPIPPGSVEQTKKDVAVLEKLFDEHDAIFLLMDSRESRWLPTVLGAAKGKIVMNAALGFDSFLVMRHGARSSLSKGQRLGCYYCNDIVAPADSLTDRTLDQMCTVTRPGLAPTAASTAVELLASLLQHPDGINAPPPPTGKDAPDPHSSGSVLGLVPHQLRGFLAEFRNMPITGAAYSRCTGCSDTVLEAYEKEGFPVLLRAFNEPGYLEALTGLDKLYDEGEAALASVDWDIDEGEGDEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P020</accession>
    <name>A0A2R6P020_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000604">
        <property type="protein sequence ID" value="PSR81914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P020"/>
    <dbReference type="STRING" id="98765.A0A2R6P020"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015312823" description="Cupredoxin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="30377" checksum="F05D5613ACBC9684" modified="2018-06-20" version="1">MLFSIVPTLAIILSSAVVPSVLAADHQVIVGGPGVLQFNPSTVTASPGDTVSFTFKQVNHTATQSTFANPCQMADNGFDSGFIPVSADNTNGPFPVAQFTVEDMNPVWVYCRQANHCQQGMVFAINPGDKFPAFQAAAMGVPVGSTLSGTSSSIASAPPNTNTATATPSLVTVTATVTISGQQQVTTYGSYPGSAAPTAAVSSDHKVVVGGPNKLFFDPANITAQVGDTVTFQFMQKNHTSTQSTFAEPCISLTQTSTSGQVGFDSGFMPVADNATTFPTFTIEINDVLSEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P089</accession>
    <name>A0A2R6P089_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000600">
        <property type="protein sequence ID" value="PSR82071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P089"/>
    <dbReference type="OrthoDB" id="3070390at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8503" checksum="7DCB091E166244EB" modified="2018-06-20" version="1">MTITIRVQYKGEAARKLAADGQARGENDPPLYAQDVSRALSLFSIPPPDNTRAIWKSGFVLCNYNITRDNVRSHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0C4</accession>
    <name>A0A2R6P0C4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v6113</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000597">
        <property type="protein sequence ID" value="PSR82190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0C4"/>
    <dbReference type="STRING" id="98765.A0A2R6P0C4"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR82190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="15075" checksum="79BFCEB0D162BEFD" modified="2018-06-20" version="1">MSMEVQSMEVELALGFAPRDFGHISQIIILRRTGFSEHFPGIVPHLLTLASNFRVPFYRDILLALGICSVSKQSCSNILKKGPGQAITIVVGGAAESLSAHPGTADLTLRKRLGFIKIAIQHGADLVPVFSFGENDVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0J2</accession>
    <name>A0A2R6P0J2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000582">
        <property type="protein sequence ID" value="PSR82514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0J2"/>
    <dbReference type="STRING" id="98765.A0A2R6P0J2"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="2">
        <location>
            <begin position="130"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="255" mass="27079" checksum="FF23D758DD7861F5" modified="2018-06-20" version="1">MTCATGEDQEINDFKKRMGKSTAPGLPKFDPNRGVHATQSIEILQPLPEVSGPGWKLKKRVIGVSENKSGVIVENETLLVDPNGTPYAKLYSSSFNLGAKALGQKFTKRIAAAPPAKDIPKDRGADWIVKDQTTPEQAILYRLSGDYNGLHIDPAIGQAAGFGGVILHGLSTFGFAARAVVSAVGGGDPHSLKYFGVRFTSPVKPGDELETSMWEVGPGPNGTTEIAFVTKDLVTGKICLGAGVAYVKKVEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1E7</accession>
    <name>A0A2R6P1E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000563">
        <property type="protein sequence ID" value="PSR83282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1E7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="5916" checksum="2EB3883ACB5F5729" modified="2018-06-20" version="1" fragment="single">FLSIQAVSTVQPISALLIVYRVAEGKCWTKDTYNEVTQSANIIQISTPRDASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P207</accession>
    <name>A0A2R6P207_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P207"/>
    <dbReference type="STRING" id="98765.A0A2R6P207"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="905" mass="97953" checksum="1758701A268A1B93" modified="2018-06-20" version="1">MSDSFADLWNSTAPTKPSNPPRTLGSIAPSGAYQQRKPTNDVFSLLAATSSSSSSRSVSPSYATAQQKTSGHGAVPTVKAIQKTSSTSDDAFSDLFSTNSASASNSANMTIAERAALAEKQRLGQLRQTHSQKLTDHTPGAWAGLDSLGTTSLIGGTNNVPSKASQPPEDDWTFTFNQPEQASTVPIVRTSSPPADDDWGLDDFVSKPASTNAARLQSQTSQSLWDLDEFDSHQAHTSRPRRASPAPINNGTSTPGSFDFGDREDGLLNEHSDDEDDILGDLAKPAGLRPSSSNGNAHPAPSPPLTTSQRSRAVSPPPHILGQIVEMGFSVQQARVALAATDTGLDVQVALETLLSNGVASGSGSPPGEARSRDRPRPRYDDPEGQHRDESSHPHQRIHPQRDHQRETPSRENPNSAAEARQLQEHADKLIAQASEIGLSVFNRANALWNVGKEKVQRAYEERAAASISSTPKNESKPKWMQETTMKDGEPYDEGWGGHVNDGFKDDHDESEVFPPRPEAQRQAKAPEVRAKPQPRSDEPSNRVKTGNLLSDDAPTVYVSPFRRKGPARSQVAAHESAPKPTLRVPSPTPLIQRKTISAPASALATSSKHKAAGTEMFKLGRYAEAETSYSYAIAALPDSHLLLVPLYNNRALARIKTGDHSGAIEDCTTVIALIGPSYHPAREAKVTKEDEGSSVDLADAFVKALRRRAEAYEGKEKWDDARKDWETIAGAEWAGRSRGEAASAAGRCRRMLTANVVEPASSKAQAMPQKSRPRPKPANRSPTPPSEALNRVREANEAAEAEDQEKHALKDTVDGKLTTWKGGKETNIRALIASLDTVLWPELGWQKVGMHELVTPSQVKIRYTKAIAKLHPDKLNVNNTTLEQRMIANGVFGSLNDAWNAFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P299</accession>
    <name>A0A2R6P299_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P299"/>
    <dbReference type="STRING" id="98765.A0A2R6P299"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR84205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50793" checksum="8BCA8F3486164866" modified="2018-06-20" version="1">MSDSRSVKSLEKASISETPLQQYDPDLVEKTWRKVDLHVMPISVMLYLASYIDRANIGNAKVLGLSKDLGLTNNQYNLALSIFFAGYVVFETPSNIIIKRTSPRWYIPTMTVIWGIVCSLFSLVNSSSGLTAARFFLGFAEAGFLPGIVFWSGLLATAIHNLDGVHGIAGWRWIFIVEGCITAGMGLLAFIFMTSNPATAKFLSPTEREIVARANEADRALKSQESFSSSQIRSAFTDWRTYVWSLMYLTTYIPVYSVVLSLPTVVTGLGYSGVVATLMATPPYGLGFVVVLVSGWTVDRYGYRFLHYVVGISVTMIALIILMAVENLVVRYVMFFFIMFMFIPISVMWAWLSSNVAGSNKRAAATGVIFSVGNVGGIISGQIYRAEWAPRYVQGHAINLACYVIALVAGFILWLSYRNDNIARDKAEGRRVERTESMLGDDLGDLGDRHPHFRYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5E3</accession>
    <name>A0A2R6P5E3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000528">
        <property type="protein sequence ID" value="PSR85652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5E3"/>
    <dbReference type="STRING" id="98765.A0A2R6P5E3"/>
    <dbReference type="OrthoDB" id="3258419at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="203"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR85652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="918" mass="103919" checksum="92EAC6A4D47B4AA8" modified="2018-06-20" version="1">MRSLDSTEDVIDIDEDKDFIAEEWIGKDKMFPPLTSIPSFILFAYEKAYAIPENLDHHLPSMDMTAAMFLHTQLPAQSPKPSFSKPETWFSMDDPCTDLSTLLSRPVPHPHMLEALENVSGQKWLDGAKSMKDRRYMNGRESFPLCSLKLWRKLQSLITTQVRWTSSTDWLAQQLAVVQATEDRLTFERSQAMLCALPYNGRVETRSVECKTLEFARFLGDSGEHAWLSQDLLDLAVDDLNQRRLADTSNNAEGILIGDLLLMQEIRRAAKGRGISKRLYKIGMQIQSGATKDIYQPTLVNKHWVAIHTNVNTGTIEYGDSLDEPQKYRPDADMASIQKWLGYFGVQMRVEGGSLSHGIQTDMDSCGVFALNTISHAVFASGLLKPECTAVARAEWFNTLVYRYLPHMQLLEPLGELKEATRQRRAMDLAFLCTSDAEHDEVAHPTCGQDRDQDAQQGLAGGIPAPKWDVVNNCDILPEPPSSDSLETYDIEHIPDRAISPLQSSSKGPVSHEPASQYPPKRLFALFEQCYHPEPNDGTKRRKLTGLGTYSMPERAEPAGTSKSARSDRDNRAAHEAGTLKISAKREETWRTGILAIDSRARFEENNVIKVICSKCRKWQKMGSVCCTSRFREHFNRCKGKLGDQRTMEEMKEQLGIMFKPLKSSKTDNIASKGLSGRVVTPVLEITCPGLTEKDDTRIQQYLRRTMAPGGGGRALVKLALERYGRKYSELDTEDREEIENAQADSHLWRNDFRRGRVYAWKCTRKVEVTGASHCSECDSVLKHRAFRRLIKRDPIDDKNLKYVNNKFRDPIMGEKYASTLGLRGILQPKSKLSPFLQLGLGIEDGTYKDNKLLGGLVYAHMIKADKTRRGVGMQNFQWGKASIGDYDRLLHIIYIESPKAYRQIAKYLPARSERSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5F0</accession>
    <name>A0A2R6P5F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000527">
        <property type="protein sequence ID" value="PSR85711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5F0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015327417" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR85711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="9650" checksum="D6CC55A10611E7BB" modified="2018-06-20" version="1">MAVKRCLLLAVVGTCLALLRGGELSEPLVAPAKEMVPSVTNPGGMFSLSDSSPLAPNERLTNGPCTVHEYRKVSNIMKLLALQRGDPFLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8S5</accession>
    <name>A0A2R6P8S5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000515">
        <property type="protein sequence ID" value="PSR87275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8S5"/>
    <dbReference type="OrthoDB" id="3231188at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="82" mass="9270" checksum="134F4F6D681D65F7" modified="2018-06-20" version="1">MKHCFWNEALINALDPVNSQPKANSAGVQWGVHTVMYGVIAFAAIIVHYLLSPDKVFKEEGEVPQKISYKLHAKEYIEKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBT9</accession>
    <name>A0A2R6PBT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000512">
        <property type="protein sequence ID" value="PSR88456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBT9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="375" mass="41088" checksum="7FE73400FC4C7319" modified="2018-06-20" version="1">MVNTRPSNASAHPGHVQLAPKRKHRTAAEMKAVRQAEDSAKAIEASKLSHQQQLLLHIAELENQVKSQPGAGPVGPPLAAELVAKGQRKGAKQAKVVDDTTPASQGTSAEGLAFEEAGKKIERARTMGKYTRADVATIRAALSSPTPMGMRQKDIMASAAIKREQQAKRKADDDIWKQLQKDEGTASIRVHCGQCWSEGKDVVPGGKEAKGGTSKSFGSFQSTVNTAIADNIDEYSDSDSNHFEELDDFSDDEYMDDLMLIKGEANDAIVISDDDDDVTMEEDNGAMGEGENVEADKGRQYGHRMTTQGMVYIIDESSEEDLAPDDILPWRRACFGERTKKATQDDLPIPHKLHNTGYLWGFLARIKLKNKLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC46</accession>
    <name>A0A2R6PC46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC46"/>
    <dbReference type="STRING" id="98765.A0A2R6PC46"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="216"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="356"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="490"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="687"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="721"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="620"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="826" mass="89619" checksum="0B759EF356764815" modified="2018-06-20" version="1">MRTKPRVSWAGQQHNASSSNAPSPQIYAPPPGPPPQWQHWQTPHSSPPQTAQRNNTLRRGNGTNLPPPGSGSRTPVVSKEEEVRRLFVICEAGRGNARLLHEAIVYAKPEDLKENTLIDEFRARCRASQERIRPAIPWATTEAENSRRGGVSGAEATEERLLSELLASNEELLDALQLYDQLERIGVEQQERESREAERKLRALDAITSFEPTSLESSLVDQIFAIGDRSGSGSVSADAAYKIFTGSQLPPDILTSIWEIANVEENSTFGKHCVGVALRLVGHAQIGQTIKEELVNQVGPTATLAGLDTPSPLHNYNVAGPSSPSLSISTSTSSSNILPPFPASSSSILPPLTPQDRTKFIRIFAKSNPENNVLSGQRARELLMKSKLPMTTLGQIWELADTQHRGVLDAPAFIIAMYLVQACMSGQLSSIPPTLPPFLYAEAAQAFSSMSSSPTYSDVGGASSTQPWTPSMPVPSPNAHGPKWGVSLELKASADTFFDALDEQKKGFLDGETARSHFLHSGLPQDTIRQIWDLADINLDGRLDREEFAIALYFIQMKQDGQILPQNLPANLVPPTLRSARSAIASSFPQPTSPSEESLIELEEPEQPIRMPVPNITITSAAHAPSSPSATNSRPPVPFAMPHNSTSMQTPVLDRSLSMSSPFARSPSMSTPESSSTTTEWEISPAESANSDRLFDTVLDPWKHGYIEGDVAVAFLSKSKLDPAVLARIWDLADIDDDGRLTKEEFAVAMYLVRRKLSGDEIPSTLPASLVLRRPTPDSAGTSETQADVTTPAVAANPTVSESAELSRVYTPPPPYQENIPAEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC79</accession>
    <name>A0A2R6PC79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC79"/>
    <dbReference type="STRING" id="98765.A0A2R6PC79"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015340834" evidence="2">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="13290" checksum="CBF045BF5E656F29" modified="2018-06-20" version="1">MRASFAVLPILAALVAGSPAPAPVAEGIKVANATLSQRDYTDARFTWYEVGQGACGGTNTDSEYQYDGGAYCWELINISYNGQSTQAAIVDECPGCPYGGLDLSPSLFSFLAGSTAPGVIYGEWSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCD5</accession>
    <name>A0A2R6PCD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR88998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCD5"/>
    <dbReference type="STRING" id="98765.A0A2R6PCD5"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR88998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="20889" checksum="B66CE58605EF5F4B" modified="2018-06-20" version="1">MSFFNNSTSSTQLDPAQATRKDIEVSNPPSDSISSLAFSPQADYLAASSWDNNDGTKVFSGGTDNAGRVFDLATGQSQQVAQHDAPIKVVKWIEIPGAGSILVTGSWDKTLKALMARLASGTRILAHVSRADVLPAFDPAPGSISATCFNRTGSILAYAVSYDWSKGHQGMTPGYPNKIMLHACTDDEVKRKAPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG71</accession>
    <name>A0A2R6PG71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG71"/>
    <dbReference type="OrthoDB" id="3270395at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="12156" checksum="348EB03A1648E5D9" modified="2018-06-20" version="1">MILLGQQEDLLLSMIVDYGRGGGNPRKYYIDDCQESDFGFLKIFLTTKRVDLSHILQESPFVGSRDVPELEPKKQIPLWDTITVMINQRKPVRGRRTCGWLARVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMZ5</accession>
    <name>A0A2R6PMZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMZ5"/>
    <dbReference type="STRING" id="98765.A0A2R6PMZ5"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="6">
        <location>
            <begin position="633"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="879"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="947"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR93781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="964" mass="107676" checksum="EEC6CBD6C0E656A0" modified="2018-06-20" version="1">MFSNPSNPLQARNGGLIGLAGTAIALGVDVASYMEKFINPLLVCFTDPENRVRYFSAECLYNIAKVSKGEILVYFNEIFDALSKLAADSELSVKNGAELLDRLLKDIVAETASVYVPQFPETEKARQRADEKPSVLIPHPDDVASGRDLQRARKAFSLAHFIPLLKDRIYVLSPFTRSYLVSWITVLDSVPELELISYLPEFLDGLLKYLSDPTEDVRIATENLLAEFLREIREITMVQRYHEDQLKAKREAESELQTRRGDGDKEKLPDITMATSERATFIPEHDDLSDDESTTPVDEKEKEVEPADRERGTWFPGIGVRIDYASIVEILIQQLDDQPEHDEIQQSTALRWISEFLSIHQQVMLPFIPRLILAVLPNLAHHVPMIQSAANRTNKLLLAVIQSLPSPSEPTSRQNTEKASISGPSTMAPGSPTPVNSTLAASRPVTANREPTLSSKDACVDSPPDVVLMQGAHLSQIPRSRPSTAVDPVRVSTVMQTVEPGTVNVQSSRPDSPMSTISMPQVQQSPEQSLLQERDPFDYQATVNALTIQFLSEHEETRVAALKWLIMLHQKAPRKILAMDDGTFPALLKTLSDSSEEVIKHDLQLLAQISSSSEESYFKLFMNTLLELFSTDRKLLETRGSLIIRQLCLNLNTERIYRTFAEILEKEEDLEFASGMVVKLNMILITSPELADFRRRLKSLETRQDGQALFTTLYRSWCHNAVAVFSLCLLAQAYEHASNLLSIFADLEITVQLLVQIDKLVQLIESPVFTYLRLQLLEPEKYPYLFKCLYGLLMLLPQSSAFVSLRNRLSAVNSAGFLHIAPKSNVSNVSSTRSKLGREEIKWSELLSHFRSVQNKHEKARRQGLGGVDELMPLPGFPIDRSTAPPSVASANGSARPGIRRRTTGTMGDAPVRPPSRALSPLNPRARGQSTLNTTVPQVPPSPTFAPGQNQRQTKRTSSLNRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN06</accession>
    <name>A0A2R6PN06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v4668</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN06"/>
    <dbReference type="STRING" id="98765.A0A2R6PN06"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="7"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR93773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="383" mass="40156" checksum="D092FE49FDC98A8D" modified="2018-06-20" version="1">MTKKIFQIAILPGDGIGPEVVAEATRILEVVSAASTDVELKLETYDFGGCAIDKYGAPLTDETLKACQGADAILMGAIGGPKWGVNSKVRPEQGLLALRKALGLYANIRPANFASDSLLAHSPLKASVAQGVDIIVIRELIGGAYFGARKELGASPDEDAAWDTMIYSVPEVQRITRVAAQVALAANPPLPVHSIDKANVLASSRLWRKVATETLQSEFPQLKVDHHLVDSASMLIVSNPKKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAGAPSVADYTSPSFKPTPGLYEPIHGSAPDIAGRGIANPVGTILSVAMLLRYSLGMGKPAQAIEQAVRKVLDDKDIGGEGLRTADLGGASKTKDIGDKVVEILKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNK2</accession>
    <name>A0A2R6PNK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000447">
        <property type="protein sequence ID" value="PSR94553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNK2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="152" mass="16452" checksum="1BA7D1097C11E6EF" modified="2018-06-20" version="1">MIVPEERAMASSGGKRPLERLKKTLVLYKKARADGDSDTKAKLEKEIPNRLRIAGKYAPDRKTKEHILGDADKFEKGDDETRESMTHPLLQGLGILLLAPFALAGATIVAAGAIVYGAGKILMGVGDILTGGPFVRRNQRAVKEESAKDKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVF8</accession>
    <name>A0A2R6PVF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVF8"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR97584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="178" mass="19790" checksum="7C559344F6A096F9" modified="2018-06-20" version="1">MPSHREEYVALLDERQLSSPVELEKERVREGAPSERATGSIHLVTTILCIFVLLDVAVYGYIVQLLRASNIDTGSLELRNSYIGLDELYHETTLVNSSRHEPIINLARRVGQVSSTDPHKPSPVDAHRMLTPFGLMAPPDRNLLVSSDVSQILFVEPHHSNSEPSHPADSHNTPVQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBQ2</accession>
    <name>A0A2R6QBQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="MLYV02000366">
        <property type="protein sequence ID" value="PSS05557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6QBQ2"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS05557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="328" mass="35955" checksum="EF62F546331CBC05" modified="2018-06-20" version="1">MSTALFMNGVRRRIAFKHDATLIRRWMSVRPEEGVVSISRKKVTIQHLQHLRKIGQPITMLTAYDFPTGRACESHHIDITLVGDSLAQVCLGYDSTTRLSLDEMLHHTRAVARGSKAPLLVVDMPFGSYSPSTEDAVRNAVRLVRDGGAEGVKIEGGLEVVDVVRRLTSVGIPVMAHVGLLPQRHTILSGYKVQGRDAQSALSVLQSALALEDAGAFAIVLEAIPQALGTYITRRLRYAPTIGIGAGSQTNGQVLVWDDMMGTWHGHKAKFVRRFGDVKGEVDKGVKGYMQAVRDRSFPAPAESYDITPDEWNKFLSLVEGGVERTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEF6</accession>
    <name>A0A2R6QEF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000363">
        <property type="protein sequence ID" value="PSS06523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEF6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6741" checksum="CA9870FB66256E16" modified="2018-06-20" version="1">MFTTTATTRVTRPEKGMSMSSSTDVRKAGGTRRTTRLNRARQPIDNISKPKETVSDERVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIL6</accession>
    <name>A0A2R6QIL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v3450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIL6"/>
    <dbReference type="STRING" id="98765.A0A2R6QIL6"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS08835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="271" mass="30994" checksum="3DF108919AB7F386" modified="2018-06-20" version="1" fragment="single">SLPCQRYSLWSSGFGSLHMSSQLEKHIHVTEKRNASSDAWHNMTFSYIRLSRLHLFPLGTIFVFWPFAVTTFTFGAIATLLHSAACVLSDICDKDLDSQVGGYTMIFFSHYTVHILTHLRAYKQPPVGNRRSFHYWCMDIHDLHNGYATRRFTMYRPPSVLKYSWVASWSIFYDTIYAWQDRVDDAKAGVKSTALLFGNYVRPILSVFATTFVSLMWLAGILNGNGVWYFCISCGGAACHLIWQLTTWNDADNTDCAAKFAVSTVWLQLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM68</accession>
    <name>A0A2R6QM68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM68"/>
    <dbReference type="STRING" id="98765.A0A2R6QM68"/>
    <dbReference type="OrthoDB" id="3070852at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS11016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="288" mass="31550" checksum="68532D806A3F2D88" modified="2018-06-20" version="1">MKSDVIRKRARHDARRGNGSSSETPSASPGASRRASPIADGITATDVNGQINYGDEQDYNTSTSSELMGALGENTQTQQNGQTTNDANGFASQFTYTLNYPGPYHPDYIPQLYNIPADALPFAGETSDFDGSETRSVKRRRMSNDSASDPPSSATSYGSYGDSYSSSSASSQSQPSSLEFPFSYSYSLFGRQHQNVYPHPPMLPVDGNSTQYIHPPMVAPEDTPMDFLHNSMQHDDADTLFATYMHPPMLPPDDSPKAAHGSLQPHPPMLPNDWAHSYDFHDTSMQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXN1</accession>
    <name>A0A2R6QXN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000292">
        <property type="protein sequence ID" value="PSS17142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXN1"/>
    <dbReference type="STRING" id="98765.A0A2R6QXN1"/>
    <dbReference type="OrthoDB" id="3357985at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS17142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="302" mass="34412" checksum="4B1ED985E780F646" modified="2018-06-20" version="1">MSDDSQSDSITVAQPPFDRKTADVVLRTSDQVDFYVRKGILAEASMIFEDMFGIPQGGNVNGESVTPVISMTENSCTIDFLLRVYYPVDNSQLETGEDALSALEAARKYMMDYAMKEAKKQFIIHAEKEPLRMYAIACSRGLHEEMRMAAKASLSRPLEDSHEYVKELDDISANAYLRLRDYHRRCCKAAGSLHYSDTTLGTRGWSRSAFSKTSFNPDRLWERQYTEWARKILQKQPSAAVIASPDTTYAFLTEDNAGRALSHIHLDRLRREIGVFVKQFAEAIDSVVETVRDRYSLEKSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3V9</accession>
    <name>A0A2R6R3V9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3V9"/>
    <dbReference type="STRING" id="98765.A0A2R6R3V9"/>
    <dbReference type="OrthoDB" id="2246127at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS19933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="874" mass="95097" checksum="1D579BD0BCC6DF5D" modified="2018-06-20" version="1">MSSDPLGGPNMAEHAVWTSEKPCTAPSHQLSPLPPSSPPSDHVPSQSSPTGLAHETEGLNDGDSEEETTDGLVDPYSIHGPALPSDGADLIYDNWGGNIACEKASTTALPLEDDEPGGPNSEVFIDPWLDLDALDHSDPLAVDPGFDELAEHLPSDGIQLPNEDAWFPWPNEKHCLLDILGAFPRAAFSEAEMEITRWVAAKLGVRDLPSIRVVKSHRSEVLKLAGSQPQVLKSAIGNLYCKTSLARILAHEVANPIVRQLLEFYPEDSGPRLAEARQGERWRCEVDSTFAGVMARADDGQDYFVSEPALATVDDIGTIQPVIPVRFFTRNKTLFAKVHRLHVERHADRDSFVVDASGALDQGSMELPLHAFFLSYPRLLESHNAYSLPPPTRIAGIRRSTASNAPGRAAAVLDVWKAPLPNPWRTKAQGKRVLALPLWWYCDDTSGNSSKKWNKHNSFLCVLAGLPREHVHLAYNIHFLATSNIAAPLEMFEGIAADLKQMQADGLVAWDCVLDEDVVYIPWALACLGDNPMQSELSSHIGLQGKRFCRVCHAHGKDNSLTGEEGERDRLTSFLFAGRPRTHAETLQALDLQWKAIQVGAPSRVDILATESGIKDKHFMAFVERFSGEISKLKASNRAEGNNATDGLPDLIDAVLDGRDDKLLFNPMFTIQGLDPHADTPVEILHVVLLGYVKYFWRDAVSRQNVAGKRTLRTRLASLDVAGLGLPALQGNTLVQYAKSLTGRDFRVVAQVGPAVLYDLLPPTAYEAWLALSRLCPLIFQPEIEDMETGDSSNSTHASSASTLLTTYSANTFTDVSQLPNSAGNSSNSTQDVSQLETSSGDSSNSTHASSASTLLATYSANISQLPISDTSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLN4</accession>
    <name>A0A2R6RLN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000231">
        <property type="protein sequence ID" value="PSS30943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLN4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="18420" checksum="2E1C2D1F028CC9AB" modified="2018-06-20" version="1">MARCALYSDIDLYIQAAPSFLPPLPPLSAVNSLLPPLPPASSLFPSLPPASSLFPSLPPISSLLPSLPPPGSILPPLPSSLLPPLSNSSASTNSGDNTNLGAIIGGVVGGFCGFVLLLAAFLFWFFRRRLLGRTAYGGSEADLAAKEAADGYRGSSEKTVDVASPRDPRFQMRNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM37</accession>
    <name>A0A2R6RM37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM37"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="16613" checksum="F58E865295201EF7" modified="2018-06-20" version="1">MPNFDMISGWLVPADPLREWWNATRSDEADAKFRLEKEECPSSFAEQYINQKHPPSQDSDLWDFYSLRIGRPGERRLYVFMMTDSDIYSIPYARVANFRLPPESERAVKIEQLLQMEGFDFENSGAKFITRPREDLVAIVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM57</accession>
    <name>A0A2R6RM57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000218">
        <property type="protein sequence ID" value="PSS31114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM57"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="684" mass="73950" checksum="3C97F0D5B2ECD2E7" modified="2018-06-20" version="1">MATRQSLPRAKANTRPAEKAGLLPTKRRTSEQVRADKEEKERLKNADLAAKAAANSAKINRIAELEDRMAVDDANEQLMQYVAPPPAPPRPRPRLRTGPQLTRTFAVSDLNAGANGGERQPEPTGVTVTHLDRAQEGLVASEALAPVGDAGYISGSEADLDVSAADEVVRSPPKKKQKASIRGAVSAIRQDLQSIKNNKVGAAVTKAVTKEKPVQNNSVHIKSWASDVFTQAMRTPFNSRAGTARSSSTATSFTSPSAILASIPVYNSESDSEGDYNGFGKDEDEIVERIAALASPSKAGVRLTSNGVVGLVQPKEGAQAQPVFRKSKLTVEAISESDEVQIVGQSTAKTKAPAKTKAPAKTKATANLNTATGAAIGTTTTASTITTSAVNNHTNADLPAGVLGRWHAQFVPTYMIFVGGQKDPWNIDDPKAEAAIKETFTVIYPNIPYPHDSDAQHGIFGVLNQRVYEYRSGFGSTAIMALHDYLGALPQLNTPELQKQHLLDMLERRAFLYEKFDLEADCVTPYWGGLLRSPFIIQTFAHHFTFTEGAKDVPMLAELEPKGALAMSAAAMERAFTLWAEGMIGFNKRGLPVVLPARNARTGKESKTLNAFAEQNWGEAIRWYVRSVGNMKPGSFAKIVDQAKAFAIQTRLASKRHVPVVLNSEQDDEIDDRGRLQDLTSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQF4</accession>
    <name>A0A2R6RQF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v2006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000179">
        <property type="protein sequence ID" value="PSS32237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQF4"/>
    <dbReference type="STRING" id="98765.A0A2R6RQF4"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="81"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS32237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="23843" checksum="1691885C2B9F0DF3" modified="2018-06-20" version="1">MAPVRASQNGGRSIAQPSSCSSTPSGKDKPSTKRKPTGKPYARKDATNQTPNVVPGVQKIKAALRQTRRLLAKEKLGADVRVATERKQKALEADLVEAERVRKERTLAQRYHKVKFFERQKVTRKLSKIKRQLEESTEKKERKKLEKVLLELRVDLNYIMHYPKLKKHISLMFPPEVRQQELEEEDDRSSESRQSTKRTLNERGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVQ7</accession>
    <name>A0A2R6RVQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13337</name>
        <name evidence="2" type="ORF">PHLCEN_2v1823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001323">
        <property type="protein sequence ID" value="PSR70775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000151">
        <property type="protein sequence ID" value="PSS34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVQ7"/>
    <dbReference type="OrthoDB" id="5083627at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="514" mass="57957" checksum="EB9233C96E4C940B" modified="2018-06-20" version="1">MSTDLASYLKGMHSQSVTCNWDVAVTYDEAKINALLADRHAQPGSGMTTEVDLRERVEDRLGEYYQNYQLNLGPPLIQFQSTSTFPACSLKTQIASGSIWTSEINDPKTKKNKKELDPNTYWITISNIHLSVLDGRADHVGDGSDTIIFPPNDKSDRHIVVDIPITGEQLDVSVDYPDGYEPPYPMKREILVTALKEFLKRETNAIAYTLASINNHKPSSGTLDLVPQAFRFVTYNAGKGLSFLTILQTKGSSSPGDTKDVQAKWVTKWSDSAKVPPVPSTQSASIIINNSFFFQSFIKPALRSQATSISDVLINDDIGGLALQCKWPKQTRKPNDYDKGYGRPSSRWPVEWRWSELHVPAVEFDPNNGSPLRLTFNHSKGFDKPATLYIHWQYKYKSTWNGKQIKKTWHKPVGDPKGDWYYDDRNREGSFNTTYTLDKTINLTALSDEDLSIEVGPQPSDWSTVAVPDEGDGLWGDDCLVYITQPTYRKCCLRNEMALIGAHFKRSFNTQQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZT1</accession>
    <name>A0A2R6RZT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="8">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000120">
        <property type="protein sequence ID" value="PSS35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZT1"/>
    <dbReference type="STRING" id="98765.A0A2R6RZT1"/>
    <dbReference type="OrthoDB" id="2525337at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015337096" description="AA9 family lytic polysaccharide monooxygenase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="10">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="257" mass="27504" checksum="4EF9C8B05A083523" modified="2018-06-20" version="1">MQKLTVSFLALILLVGSASAHTIFQKVYVNGVDQGELTGIRAPSYDGPITDVTSNDLICNGGINPYLQPVSKAIIPVPAGATITAEWHHVLNQTAGDPADPIDPSHKGPVISYLAKIPSATQTSVTGLQWFKIYEAGLTPSTQTWAVDTLIANKGKVAFQIPSCIPAGQYLLRHEIIALHAANSYPGAQFYMECAQLQITGGGSANPATVSFPGAYKGTDPGIKINIYQTLQNYTIPGPAFFAYSVVNIFYDYPFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4D7</accession>
    <name>A0A2R6S4D7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4D7"/>
    <dbReference type="STRING" id="98765.A0A2R6S4D7"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="15778" checksum="F69B0B91D5AE17E9" modified="2018-06-20" version="1">MLSRQLALDSSMETQQARALYNLGMTGIPITNVNNNCATGSTALYQANNLVKGGLVDCALALGFERMSRGSLGTTWPDRPSPMQPFNAASEETENQLTAGTNFGPFAPRMFANGAQEYFENTEGNTLSILAEDWKRKDIHLGLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4F5</accession>
    <name>A0A2R6S4F5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4F5"/>
    <dbReference type="STRING" id="98765.A0A2R6S4F5"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="182" mass="20610" checksum="0A2180E12AECBF2E" modified="2018-06-20" version="1">MDWEDSSGSSSDDDTDGMWNIPKAVHTVGETALSTTRGSMRGLQHAIQEGWLVQRARDMCSFAHDRYRQAAQAEAANLPEGTIPKMSFRVILMMLHDTVPDVYRIAEHAKRCLPLLREHHRRDELLDLSIDAGDSASSRGAHELALQSYMNALSLLEDDPWKSKPERTMALYLKLAEWVSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4I2</accession>
    <name>A0A2R6S4I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4I2"/>
    <dbReference type="STRING" id="98765.A0A2R6S4I2"/>
    <dbReference type="OrthoDB" id="3245657at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015320715" evidence="3">
        <location>
            <begin position="23"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="33574" checksum="F454CF9E2A60DFA1" modified="2018-06-20" version="1">MSSHCLRTSLFAAPILLSFVSADLVNITVDDTNPDPLTGAIFEYSPSGWNIGPTCHKCVARPNQQDAYDGTWHDATSRDSPQTASLEFNGSAADILFLIDGQVLGSFVYTPPGDPGAYSYNILLYGNDSIPEGQHTLTVQNGEVNGPDSLILLDYMVYTRSEDDPTSWPANLQPSSSITSLSSQTTSSSSAISITQTSRQPLNPSSTLPLSASQGINHETRNLMVVSSVLGTALLVLILFCYLRRRSYSKNLKTLVTTVIPYQLKEAWNVLNDSSEPEHRDHPEEITQPGLPPAYEAVEGERDHRGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Y4</accession>
    <name>A0A2R6S4Y4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000068">
        <property type="protein sequence ID" value="PSS37279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Y4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Y4"/>
    <dbReference type="OrthoDB" id="3262759at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36127" checksum="9B8CB798A5AD9728" modified="2018-06-20" version="1">MSIASTILPSYPELSPWDMDPVPLGLKPPPLQDDLFDTPGFAAAALKQAQHTGMNPLHIWYGTNPLIVFDEQMKSASLPFNSYIPPPPPLPRARIPDDITVLEQIFPRGNTPLFKVCIGQDIRLLKVFPDRDWDEEFNSPADLPPPMVRFEREKRAYAHLLHYGICEKGTIPRCYGWFDLSRAHVEHICALPGIDKSLATLKDNRRTPKAIVLEYFSDAVRLSVTNITLDIADVALRALHTIHSAYVMHNDIHRHNILLLPDNRVIWVDFDMSTCLSEAGSKMRRQDLLGELEEGWRLFYKFLVWFLCLVTATNSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5P3</accession>
    <name>A0A2R6S5P3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5P3"/>
    <dbReference type="STRING" id="98765.A0A2R6S5P3"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39514" checksum="5AA7ADF737E39011" modified="2018-06-20" version="1">MSSATVTKQDEKVSIGDNNNEQAFTSYPWVVRYPLAGFTNLFALGLKLFRPVAPQLVPLAVFVLTIPILVFFSISAGWFVWRSIAVGWETSLYLQYGDGVPPYAQLNLPPLVNQQPYDVSLHLVVPASQPNYELGNFMITLTLLTPLNKTIVSTRRPALVLPPSMSPLSYLIGRSGTVELHIPLLYNIDVGTRNAVARVELGRKDQWRTLGSGEGRELSVLSAFLRGVVVHNGLRGLFTRFPLVTSVIASGTFLFISFVVLASCLLPMIQWRFPEDTQSTDTELHEKPSRRPKRELDESAPAPRKTRSRSLAAPRRTSSQQAFRTEDDTAAMPSSSSTPLRRRRSRMSQQSDPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5Q7</accession>
    <name>A0A2R6S5Q7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5Q7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5Q7"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="218" mass="24051" checksum="C737B1EF9472E783" modified="2018-06-20" version="1">MVGSPPSAGGSTIENRTTPNAVLTTAVPQDVHSGSAGTPSFLPSYLSRNMENLDLDGPEIPTTRPIARSQYSLVLDDDPLPEFWEAVRMPDGNIFFVDHKTQTTTWDDPRSRAQRDTEAVDINSAWAVRLMSPLPDTPEGFRTQFSSLPTEPLADAYLHKDPPFPELLRDGYVFNPSFPNLPEGPLPDFWEEQRGSDGHVYYIDHAGATIIKKASLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5X3</accession>
    <name>A0A2R6S5X3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v486</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5X3"/>
    <dbReference type="STRING" id="98765.A0A2R6S5X3"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000172">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="7">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="638"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="743"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="878"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="969" mass="109936" checksum="D8BDB363E2F6978C" modified="2018-06-20" version="1">MPSAKIYYDADADVGLLEGKTIVFLGFGNQGAAQAQNLRDSGIPNEQIIIANRPDAYAEDAKSKGFTVEHDFAKAAVVADILFLLIPDQVQPRVFNEAFAPSLKQDATIVIASGYNVFFKLLNFKPTQNVVMVAPRMIGSSVRSLYEKGKGFPCFVSAEQDGTGNGLKISVALARAIGATKAGAIASSAKEETAMDLFAEQALWPNIIMLFREAFSVLKEAGCSDEALCYEMWMSKEPAEIFERAAEEGFITQLKHHSSVSQYGQLNGALKLDGSDTRAHFKDILYNQVLNGKFCKEFSSIEPDLEKEGASNPLNQLYAEHEKSELSQAEQRNERDLSISPSAEEDVAGSSSIVLKPQDGDLKDVQKNLHHRPTKFYGSLQNPVPIETFELSKTIVWKSRNQSTETHRTRRSHRSKSRERDRERRERRRERDEYEERRKSRDRHDKGRSRERPHRDREYDRDRDREREKRRERDGDRHRTDRDRGESRHSHREREDRDYRDRRRKREDGVDEVLDERYKRKRDDDGPEESSLPAPPPSAGLPPPPPPFADSPRRLRERSRESERRYGDRPPRSSRDARDEFDDLPRYRRGGDRERGREKSIEVEGKSTTPAARPSPTYEPPPDDPLNEEPREDDSEARSVFVSQLAARLTARDLGYFFEDKLGEGSVMDSRIVTDRISRRSKGIGYVEFRTVELVDKALALSGTVVMGLPIQIQLTEAERNKLHAGDSNLNLPPGVSAPHGGMQLYVGSLHFNLTESDIKQVFEPFGELEFVDLHRDPMTGRSKGYAFVQYKRAEDAKMALEQMEGFELAGRTLRVNTVHEKGTVRYTQQDSLDEAGGGNLNAASRQALMQKLARIDQAPARPQPIMKPNIPQAMQSRSVLLKNMFDPEEETERDWDKDLAEDVKGECEEKYGHVEFIKIEKESQGEIYVKFDSIDSAKNAIQGLNGRWFGGKQVSAAFISDAIMQAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6H4</accession>
    <name>A0A2R6S6H4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6H4"/>
    <dbReference type="STRING" id="98765.A0A2R6S6H4"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="378" mass="42800" checksum="6485A31FC6A718AC" modified="2018-06-20" version="1">MDGVDQLHPSPHPSPAPTTESLFIQHHSHQDTQPQDHREPDPPVDQIQDDQPIDEEPLYVNAKQYYRILKRRVARARLEEVHRLSRQRKPYLHESRHKHAMRRPRGPGGRFLTAEEIAAQKANQPPDVGPSASTSQNGDEDDDPQLMEQDLEHDSEMASPVDDQKHAALPLPPATQEKPLEPLQQPRPSIQPPLQPRPQVQIHTQAHSHSQMQRPQLQTQRPQPTPQSQQQQTQSMQAPSPHHHQPVQSPYEHHMTMAHSNGSLDLLNVNYHPVSHPATPTPISPHASVSEGMQAPERVQHMHSHAGHTQHDHPRHLSGHSGNGQPVAPTPAPTVTLRSPFQAMQMHHVPHPHAHARHHHSYVNRAEQLYAEQGIYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6U0</accession>
    <name>A0A2R6S6U0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000020">
        <property type="protein sequence ID" value="PSS37909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6U0"/>
    <dbReference type="OrthoDB" id="2742096at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="133" mass="14826" checksum="9CFE2A6F70DAC95A" modified="2018-06-20" version="1">MPDQPLILEIQIKPNLKRLVGGDTIEGEIVMYVSLLEVQHYQEVHAIFAGVIETAGWSGAWKTVQEQEPIRQFCFGEYAAAAVALTLPDIDMLPIATSIPFTVKLTRFTKPMQWKDGRGTLDPVFPALVSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6V5</accession>
    <name>A0A2R6S6V5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6V5"/>
    <dbReference type="STRING" id="98765.A0A2R6S6V5"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="102" mass="11186" checksum="E446025B3BB020C9" modified="2018-06-20" version="1">MTASVTGYSIIQGFTSTLDTMLPSAWTSSQPKLVGLWSQRMAVVMAACLIYLNYQPIMLIWLSAESILLGLKQDPEVAHLAGIYLKYALIGLPAYAFNSISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6X8</accession>
    <name>A0A2R6S6X8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v92</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000008">
        <property type="protein sequence ID" value="PSS38061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6X8"/>
    <dbReference type="STRING" id="98765.A0A2R6S6X8"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="268"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS38061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="326" mass="35077" checksum="7956EF666ABE2467" modified="2018-06-20" version="1">MSSDKDVLLSMGFDAARVEWALKATSGRGLQPAMDHIIENEGTPVPDPSAVSGTQISQPTGGAAGEDMDDEDVAALKAVYGHKGGAEAQAAAAAADVEAKSIKCSECGKIFRNTSLAQFHAEKSGHDQFEESTEEIKPLTEEEKKQKLAELRDKMAAKRAVKAKEEAKEHKANEAIRRKSGKDINEIREELKQKEIIKEAEAKRREKVEDAKARAAIKAQIEADKKARAEKAAKEKALREGKAFPETSAPATSASAPSGSIASGIAGRDYPQTRLQIRMASGGQPYTTTLASDATLREVAEFLAGQSLSVDVDTVTFAQHFPRYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Y7</accession>
    <name>A0A2R6S6Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Y7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5430" checksum="5A822862341CBE86" modified="2018-06-20" version="1">MAPTLLECEAVEVEDAPGEPAPEVLEAPEELVGDACIVLFVTLVTEGVSPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDI1</accession>
    <name>A0A2R6NDI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001355">
        <property type="protein sequence ID" value="PSR70407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDI1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="10695" checksum="03EF91A60A939E4B" modified="2018-06-20" version="1">MSSDQAKSPPEQPAQPAAVPAYPPQYSGAHYPQLPPGAYPPPYYTYTPLADPNHDPNAPNGPPMPYLMAFPPPPPGMVYAYAPPPPVPGQGTSADFTRRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDT6</accession>
    <name>A0A2R6NDT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v13690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDT6"/>
    <dbReference type="STRING" id="98765.A0A2R6NDT6"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="276"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR70439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="637" mass="70311" checksum="889F1BC8A9FCCA42" modified="2018-06-20" version="1">MKRSQEFSPSSPQQSTSAPAQKKLKVSPQVSHGISMQDQQDTGTDLGTADNGWTKVEKRKAKKMRRVESRLDTSTPRFLYCKGEIVRRRDAVGINDIRDLVLHIVADAPPLGWVRIENPRSIQKVITLLIPGLTPENLSLPPLPTSATSNPNIPLEIPLPPGPDVPYHGVPFIARTFSHACPTRAPGDQTRMHSVLSAFFQSPVSGEEKKRRILERVTSERAQEKSPMRYILTTEQMLENDYPLPSYVADVFEKPIGWVETPKHLDDPTSSNSEARILSMDCEMCQTEDGKELARVCLIDYASGIVLYDKLVKPKKPIIDYLTRWSGITEEALSNVTITFEEVQSHVLSVLSATPTPILLGHSLESDLKALKICHPLCIDTAVIYHHPRGRPLKPGLAWLTKKWCGREIQNRGEGGHDPEEDARACLDLLRKKVEHGPGFGEFKMDFESIFERMSRARGGAVTCAVVDHGNPGNWHGSKATTTVPCKTDEDVLQGLLGAVNSHKFCFGRFTSIADTLGWITNRTAGDAALEGPQPSPPLVPEDISAALSALDTRLNSLYAAVPPRTALMIITGHSDPRRMAELNARKATFEAAVRSGKTLEDMPSEARWTSADGRALEEEVEKAKRGLLFLGIKDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE37</accession>
    <name>A0A2R6NE37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE37"/>
    <dbReference type="OrthoDB" id="2804425at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="520" mass="56062" checksum="C5704383FD3097E7" modified="2018-06-20" version="1">MDPLPLTALGSKRVTRSKTGHQTEASSVVSEPLGTVPGNIVPEKANTRMSMGDKSTGTEMVAGLPVDTRPMDVDVPPSRASTPPATPTRQEKGKGREQQVPWTPTGRSSLPSPPCTPSITISATAMAATPSPSSVNSSPFTPFTLPSALHPAWSPSAGMSGTSSTLTTPSTATSSAMSSPLTPFSSSSSPRTASSPLSPASRSSWDQKMYDLREGLISSPNRVGTYLGDPTLEVSAMFQWVRFEKTSVLCTIDVAAAYKVALEEFNKDNSPDAEAPLPPVAAILCGVYRIDDDKFFLGPDGNWNPYKDFGGLDDSKATCLLGQAAEALFARDYEVLERNVRILVDMGRSGDGRKLKGIYTDTDHGSLLKLRHVLFEELDDDEREAAQNKELGSSDDEESDITGWPVKKKQSKLAIKKMVNKYRVVPLPAFGLVGDKIRPGKYETVLKGADVQAHFTLLHWPIKDKRGASDTMVADVLNLRVYVPARLKPVAYAKAAKRSLEKDLFTPDISAKRSRTMGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE80</accession>
    <name>A0A2R6NE80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001336">
        <property type="protein sequence ID" value="PSR70680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE80"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7059" checksum="F19470ABEFA53B0C" modified="2018-06-20" version="1">MSTIAFMGLAILTITAIICPHAYVLTKFMLLMNQIVKGSQASTYNSGWGSYDNNNNNAGGWGNTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEK8</accession>
    <name>A0A2R6NEK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001312">
        <property type="protein sequence ID" value="PSR70814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEK8"/>
    <dbReference type="STRING" id="98765.A0A2R6NEK8"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="20300" checksum="E95E3F8E08CF8D20" modified="2018-06-20" version="1">MHSMLELLEEIAFSGALESRAHIAEESGKMKKQLKTRAVRLRELRVKKFEEPDPRVRWSVTERNLGLEGQKGTVEEYFAEICHEARHAVQRYSRALFGSLFGLPLTVAHTAEAMNLLLHLFQFAEEHREEGRDLQRELDRFAPELNESVDEIWKKPRDAEAEGQTLSVITSTIIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEL1</accession>
    <name>A0A2R6NEL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001315">
        <property type="protein sequence ID" value="PSR70805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEL1"/>
    <dbReference type="OrthoDB" id="2986975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="26725" checksum="E94E9C93A4C73796" modified="2018-06-20" version="1" fragment="single">ISTGRNQPAELTLAERYAVACRSKTESRRQRKDLPHTLELAKGMKVLVTENLQTDLDLTNGSRGEIMNIILHEDEPPISGDGVVYLKYLPAYVLVKMGRTRASKLAGLEEGVIPIEPAKTTMQIKVSMPGNKFLQRTVHRRQFPITPAYAFTDYRSQGQTLPYVIVDIAAPPTGVFPNGTRPGTSDRGRTIGRVGQEHENMVARDGRGRANGKHTNSSGGERKQRKIAHSKEHGTHEEHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFB4</accession>
    <name>A0A2R6NFB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFB4"/>
    <dbReference type="STRING" id="98765.A0A2R6NFB4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="221"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="552" mass="62601" checksum="863594AEBBAC2B1D" modified="2018-06-20" version="1">MSVRRQVPSRNKKLVLDVIAGVQLVFQADNIAELYKKPRLPHEPVVKDDVLRYNPAEDLLIQINNLLSYFVETDEIKPVTVDLRSEVIYEISQGVLLLEEVCEFHVVITYSQFQHRRDLKQQFEKRTSRLFCIRCDLLIHREGRPSWHFLREKTPNIKAKKPKTPEGQKGAGSSKEEPKTFTAGEEPSNTSKPQEVADHPKTDEEVVDHPKAEEDPGFSEVSKVDGPNLEATGAVEKYKRLDDRGILLWCTWEERDLAPENRPFTDAFLFMRGLLAQRTFSLIKQVSSIFSHCIAWLLGLTCLSNKKMQEAEARNALVASSFLRRLMTTLAQRADMLPDFLFLTDVIPGKLLGAGAFGDVLMGSYEGRKVALKTLRIFAGVDLTGYKEKLMSIKQIARGMTYLHEQNVVHGDLRGDNIFLDENFDVHIADFGLSVFADGASGNYHSVRTGNPRWLAVEVQFPERFPHISASGRPTYAADLYTRGKAPFYHIPGDHAITMHIGSGGRAPRPVNPDNDEMPEALWNLVERCWREMPEERPTFSDISKELEIILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFY1</accession>
    <name>A0A2R6NFY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFY1"/>
    <dbReference type="STRING" id="98765.A0A2R6NFY1"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000001">
        <property type="entry name" value="Sentrin-specific protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="362"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="591" mass="67757" checksum="752E1E5765D0302F" modified="2018-06-20" version="1">MNLLKRPSPDALLPVARPGKVPRTSQQRVDGQNSSPSQYEALAARWKDCGMQSLALLKETIAVGVTTLFGGEVTQSAATSYLISPPPSSPPSPPRPVVAPQPQPTATSSKSSIQSHGHSSAYQQPEASTSRLQPRSSSAKRRETGLLSPPSSLATSSSSTSFVGLYPELEEKLKDVRTQKDKAIRRPVKHRQHIYHSKFKADVQEDRRKGREDMERELYDLRRREGYRSSLKEFRGWLGYKERLEMLERRESLAPSPSLVDLRQAQGSGSSRRYSMPEPPSSGFLERALRNAQATLKSPKPPPPFSPNLDQLRHWKLARDDEIEQRLRPKRKPLPASLPREDDAAVDVLMTKRGVISKCVREQVSDKDLFRLRPGQWLNDELINFYGQLILSRSEDSRENPRTIGSKNGRLKPLNAHYFNTFFWSKLKNEGYEKARLAKWTKKIDIFSKDVILIPVNHNNAHWTGAAINFRHKRIESYDSMNMDRSQVFKYLRNYLDAEHRNKKKKPFDFTGWQDYTFEDTPQQENGYDCGVFTCQFLESLSRGEESFAFTQADMGYLRRRMVWEIGYARLREDTLPPKPPDDDEEPEYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG93</accession>
    <name>A0A2R6NG93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG93"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6818" checksum="26141E741CB488AD" modified="2018-06-20" version="1">MDFSQFAQMDGSNMLDSFSAGHSTSAEGALIPFNPINDRKTELLLMGWPMHLPEPEVTRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGM4</accession>
    <name>A0A2R6NGM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v12591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGM4"/>
    <dbReference type="STRING" id="98765.A0A2R6NGM4"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR71540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="738" mass="80674" checksum="2A41D1C6261F5194" modified="2018-06-20" version="1">MDLQTMLKKVKQKQYKSKREFKDDLDLIWSNCFTYNATEVRRPLRRPHAGLTFRDKNHPLRQCATRLKTKAETLLKNITDRKDRADPAIPAELASRSSTPKLNGTIVNGNGVARARMSFTKSPSPAKLPIGAISKQTRHVPVMESTIARTAEGMATFLRLDQQIEAILNGELPRSGLGLRSLEEELMEYAPMFLEENGGADTGSFATEAGIGEKRKLNGFAESRPRKRAKTTQEDKDIVDLWWDAMQSAVMIGNGVPTLRYSSSGDPSDTTPPPTITDPPRMPGQRARKKRRKQTGDVYSERSMLHHMNNNIRILRRVRSTHARLTALKESNDDAAGTGVVQPSQPSFEPLAADEVEAVVEDTPWPLPSSDVELGEENADHCLHWMGTKVLEHAGFQGASKVALDVLAGVTSDYLLNVGRTMRFMCDKYASKMTPEEIVLHTLFESGITRIHELERYINDDVVRYGGRLAELEKKLASAYREATVVEAWDDDALFKMEEDEEDGEFVMGNFADSFGEDFLGLRELGIAAEFGLSSLTVPKRLLKGKNKGNLQQTPDAKPSEPPPPFPPPPPFIQLDSKKVDDQIGLLKPFYQQRISALTVTAPPIPSISITMPGLPIPLNPFGPPAHHTAQAADYPLVALPDDPPSGVHTKLGPLGQVIKTGTSANATKKKAVPAKTKGIKDAADGDGAETPLTATTPTATAPDTPKKPKGSGKKKKGSIPVDVFPAVMMTSTSSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHD9</accession>
    <name>A0A2R6NHD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHD9"/>
    <dbReference type="STRING" id="98765.A0A2R6NHD9"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="475" mass="54865" checksum="F3D0BDC35B4A13F6" modified="2018-06-20" version="1">MPRILPRILKRLDEIHFSSQPHKLNLTKLTPIKQRKSLWKPTPSFSLSPHGRTQSILLEDVNPVNDRRVFRPHKMMPPRLRVRRPEKRNATATEVRIEDTPRRMTPEERGWWSNPYLRMLHEPMRRCLVTLRLLPKDFLIRLAPFKMADIRGAPPSVGLFPDGLEHPWFQRRRNGCGTYILCRKVIMAEFGKGAYKRIARSITLHKLIEKQIDHLLRLRVLQELHVLGERLRIRERNAEKRPVLRRLTREEWKEIRATGAIPYKNAVAVLVVPPLNKDPNTKKRPEPSFSSNPIVEEPLVSKRPLPPVSVLHPTSPELENGDAESFLPNARLPLYNGLTLFPSRAQRAALHAALNKVISLERRTICREAGRTWTSEKDNAVDKSNTQKTDKSNTRKTDKSNTRKTDKSNTQKTDKRAQNEKKSSHAYLLCSDAKSLQRADSVPLAIALWRIRMWEGAGWGAQNGWILNRPKTADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHR8</accession>
    <name>A0A2R6NHR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001236">
        <property type="protein sequence ID" value="PSR71873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHR8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7260" checksum="2F9B23EC8A4978DD" modified="2018-06-20" version="1" fragment="single">EFVQVVEFLQHMLLTFSCLRVVPWFLLIVLKLPDIRFAASALKLGGVELIGNCEGRSLLDDNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIF8</accession>
    <name>A0A2R6NIF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIF8"/>
    <dbReference type="STRING" id="98765.A0A2R6NIF8"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="373"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="686" mass="71681" checksum="E4778761C0DD436D" modified="2018-06-20" version="1">MVVLQLAILSGGKTLLTKVSGIAAFNSNPSGYQVFRNVKDFGAIGDGNADDTAAINAAISSGSRCGEGCDSTTTAPAIVYFPSGSYKVSTPLIALYQTQLIGDARNPPTLLAAPSFSGIALIDADPYLGDNWQYYTNQNNFFRSVRNFVIDLRQVSGSATGIHWQVSQATSLMNIVFQMSTAAGNQHQGIFMENGSGGFLGDLVINGGNIGATFGNQQFTVRNVTFNNPVTGVTINNAQVGFDLSIGDTSSTGNQGVGAEAIIDAVVTNTPIFVRSSIPSNGHLQGSIVLNNIKLTNVPIAVGVKNGATVLAGGSMTIDSWAQGNVFKGTNSAGTFTQGNIASIPKAPAVLDSAGRIFGKSHPQYADYSPSDFVSVRSHGAKGDGHTDDTAALQAIFAQYAGCKIIFFDAGTYIVSNTINIPAGTQVVGEVWSVIMGTGSTFTDYNNPRVVVQVGAPGSSGVTEITDMIFTTKGPAAGAIIVEWNVHDPAGQQGAAGAWDTHLIIGGTDHDLDTPGSAQITLYSGRGVLSESQGPVWLIGTASEHHVNYQYFLRGAANHYIGLAQTETPYFQPNPVPPSPFIPSTNVDPATLGVGAAWALTVQNAQNILVFGAGFYSFFNNYNTACQGTQNCQQQILNLDSVSTISIYSLNTVDAISQISVNANAVISGSSNPNGFSNTVTAWTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJA0</accession>
    <name>A0A2R6NJA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001196">
        <property type="protein sequence ID" value="PSR72318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJA0"/>
    <dbReference type="STRING" id="98765.A0A2R6NJA0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="52430" checksum="1824E0862824B716" modified="2018-06-20" version="1">MEIQSYLHAITSNIYGNTTSLFVVLTVIIVLAHVVPYLADPAGLRAYPGPILAKVSKFWLAWVAYHGHINTSVHNAHEKYGTFVRISPVEVSILHPEALQQIYGHTSGTTKSDMYGAFAQFGGTLSVFTTRDFVEHTRKRKIKAHIMSLKSVVEFEPIMHSHQRILVKKWDRMCEAGAKGKGGEEGSCVWQPGNGRAWFDCMQCDLAFGSPFGMLDAVRDTTQIATSQMAAVESYGVEGAKLEYVTISAVEAINTASGFAVFLGVLPPWVRPIVSCFFTAKIKSRDNLGSMVATAVAKRLVSSVSRQDLLSKLLEGRDEEDRPMGRQELSAESLCLLGAGSDTTASSTGAITYFLAQNPTVQAKLQETLDQVLGPPGGDSDNGDAAPYNKIKNIEYLQDVINEGLRLHSPVGMGLPRVVPASGMTILGKAFAPGTVVSCPTYALHRLPSVWGADAEVFDPDRWSQGDRTTMLKAFAPFSTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKA8</accession>
    <name>A0A2R6NKA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKA8"/>
    <dbReference type="STRING" id="98765.A0A2R6NKA8"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="9911" checksum="DD835C2C8BB9DA6A" modified="2018-06-20" version="1">MSSFGKVFHVEKRWKLIREMGSGAYGYVISAVDDVSGEPVAIKMITRVTQKIQLAKRALRELTLLRHFAHENITGLIDVDISPNLDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKD1</accession>
    <name>A0A2R6NKD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v11360</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001136">
        <property type="protein sequence ID" value="PSR72761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKD1"/>
    <dbReference type="STRING" id="98765.A0A2R6NKD1"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="14">
        <location>
            <begin position="225"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="514"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="554"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="594"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="958"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="959"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR72761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131373" checksum="B20D995E0C750DD8" modified="2018-06-20" version="1">MSAMMQFDEHVEHVEGEDSPSTPRFSRLLTSVLGSPFLTTSDLPAEAMLALRMDIDELETVDGTFNTVPRAQTITRPSSPTPSFSTDTYSFVNWTEHSDMFTPQHRPSVSDAAPACSFLPGSIRRSTTYYTGPASSPYNTLRCPQSGSLKRSRSFSLLPRLWDVLRESSPGKKGKRRMDLANAYWGDLEIDGYIDYTNLPPLDGEEGELIDDEACFIDVRAVTGLDIVAQIPHEVALHLFAFLELPDILSCLCVSKTWHQLASDNSVWRSLFGRKRSTGWEIDFRRSNTSTLTPAARFASAHRTPKPLSRSIPAPLEFDWYQMYKTRAELDRRWNAKSYLCNGSEDKENANIWEPRARRLSGHTDSVYCLEFDSSRIITGSRDRTIKVWSVKTGRCLATITGHRGSVLCLKFDQDFDLDEANSLTEDGLQGWRKGFMVSGSSDTSVCVWDLYAHPSEGEDGEEMAIMAEMRGVLRGHTGGVLDLRISAKWIISCSKDTLIRVWNRSTLALHCTLKGHEGPVNAVGLQGNRVVSASGDGNMILWDITKGERLRTFEGHDRGLACIDFKDDYIVSGSNDCKIKVWCASTGECLRTLLGHDMLVRALSFDPRSGRLVSGSYDRTVKVWDMHTGKMIREFKTCHASHIFDVKFDCNRITVLTGLAPDGGLYIPESIPHLPEGWQTAWAHHSFVDLSVEILSLYISSSEISRKELRALVEKSYGTFRHPDVAPIKKLNDKTYILELFHGPTFAFKDVALQLLGNLFEFFLSRRNAKKAAGEKQEQLTVVGATSGDTGSAAIYGLRTKSNISIFILHPKGRVSPIQEAQMTTVTDANVHNLAVKGTFDDCQDIVKALFADKAFNAKHHLGAVNSINWARILAQTVYYFLSYFHLGRHLSSTLSPDELTNIKIQYVVPTGNFGDILAGYFAKRMGLPMVKLVIATNSNDILARFWKSGAYEKTDTSAEPAEGATAPAEGASDGKQGTAVGGVKETLSPAMDILVSSNFERLLWYLAYEALAESDAETRPGACETLNSWMQKVKTDGRVEVPTKVVELARRDFLAERVSDEETLDSIRSYFGAEPSYVADPHTAVGLAAARRIALQNKPSTVQIVLSTAHPAKFSEAVTRALQGSSRFNFERDVLPREFKGLLDKERRVIDVESPDVELVKQVIEAYAEAAVAPSPEGTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL93</accession>
    <name>A0A2R6NL93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v11043</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001107">
        <property type="protein sequence ID" value="PSR73096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL93"/>
    <dbReference type="STRING" id="98765.A0A2R6NL93"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015302259" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="22450" checksum="F6DD5693220E218B" modified="2018-06-20" version="1">MPTMWMSLVLFFLVSVSAHMMEVPASKKECFFEDLHVNDKMTVTYQVGGGGHLDIDFWMTDPEGLVLHKHIKQSTGTVSITTEKDGRHEYCFSNLMSTVVDKLVSFNVHGVVYYDDDDTVAPIEREIRSLAAGLMGVKDEQEYIVVRERTHRNTAESTNDRVKWWSVAQVIILFLAVAWQVYYLKDTDTRPSHSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLI0</accession>
    <name>A0A2R6NLI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001095">
        <property type="protein sequence ID" value="PSR73242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLI0"/>
    <dbReference type="STRING" id="98765.A0A2R6NLI0"/>
    <dbReference type="OrthoDB" id="2100988at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34286:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7803" checksum="12384DD16C3635C2" modified="2018-06-20" version="1">MEAHGGWWTRPSNWKSNTAIAFAGILAVTYGAFNVSREKEWRHIDPVRPIPSMKWTKQYREAESKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLT9</accession>
    <name>A0A2R6NLT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001079">
        <property type="protein sequence ID" value="PSR73363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLT9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="12739" checksum="BAEC173B114847F7" modified="2018-06-20" version="1">MSSEVSCGDTSGELPVSLIEISGKASLGNTSGETSLVNISGPSSLEDTSGETSIGDISGGSRDAAINGSNDVHNYAPRNEVAESIEPDSEPQGPPLATASGMTGAQAHRKKISKIFQPTAHNTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLX1</accession>
    <name>A0A2R6NLX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PIN-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001082">
        <property type="protein sequence ID" value="PSR73337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLX1"/>
    <dbReference type="STRING" id="98765.A0A2R6NLX1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF4">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49866" checksum="F6B90C586D39337D" modified="2018-06-20" version="1">MSDSSKSFGAAFSGALEGTISVLLTLFVGYYVARKGLVDHKTVNRITRLCAELFLPCLIIVQMGPQLTAKKLGSLWILPLWGLASTLLAHLLGWFGQAVFRTRWWLIVAAGRPNSSALPLLLLQSLESTGILDALSQHGESAKDTLDRAKSLILLNVVVQQTFTFQIAPSVLKKDREIHGKATDEDDDTEGGNTLSATSSERQGGNINPIIQDTERVGLLQDQDGHAYGTGDAEANYPEALSPIVDEPDIHWPASLGFMEQPVKMTISKMSPPLIGAIVALVIGLVPPLHDLFYSRDSPMYTSVTQSAQNLGELFVSLQMFTVGAELALVPHAKPGWIPTIYAMFIRFVMMPTLSLLFVWTTAGRDCSNQTDWSAVSRFLLILIPSGPSAMLLANVAELVDVDQGPVAAYLTISARLSFSSRMVSFSSYLLSQYFFSPLMAIVTSLALTVVEDASKRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM05</accession>
    <name>A0A2R6NM05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM05"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9454" checksum="74B13D19AC8EB463" modified="2018-06-20" version="1">MTAYTALKHLREFCSSAERQDGTPDTAKMVWRVQMKAGKMKGVPVLLQKNETAKLNGFPNRQLAGRKRVGLLVAEHLSKLRENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMF3</accession>
    <name>A0A2R6NMF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001070">
        <property type="protein sequence ID" value="PSR73522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMF3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7328" checksum="C9ECC1C843EF7F42" modified="2018-06-20" version="1">MPPAVCIMSTNREIRLKDLTHATGQGKLPRRRLRPCVQKLLGFIVRPKSANGITHLPHPCTGDTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNF5</accession>
    <name>A0A2R6NNF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNF5"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="17548" checksum="2B61F9FEF06578DA" modified="2018-06-20" version="1">MPARTLSPFRATDRALLSPSSRYPPYPPPDSPHHEQQIFQRRAEDPTVLYDVTGPPHDSIARMDHNPFTAGGHADAVPHPMRRPSTVGWYIVSGQPHATAHGPTPSPPLAGWLPHPPHLTRIAPLIPPPPLIHKVWILDCQSCGTFLTNRGMKVSNKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP16</accession>
    <name>A0A2R6NP16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001014">
        <property type="protein sequence ID" value="PSR74196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP16"/>
    <dbReference type="OrthoDB" id="5514856at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="7966" checksum="1507B6A1A6485F11" modified="2018-06-20" version="1">MARRAAPPGAGPAFYSGAPTRGQISDPDESSISAFLREEIFSPEKLPGNVSIVTGLVVFFGGIAAMRTWGELMIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP33</accession>
    <name>A0A2R6NP33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001010">
        <property type="protein sequence ID" value="PSR74219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP33"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="8024" checksum="A13B36DBD98844D6" modified="2018-06-20" version="1">MDMLVGIYTVELAGDIWSSQVLFRRCWLLRARLHCVNQWEVYKILQVRKWVMDPYLHWGDAQDEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPQ6</accession>
    <name>A0A2R6NPQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPQ6"/>
    <dbReference type="OrthoDB" id="2827684at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="526" mass="59681" checksum="44D5F907D60173BD" modified="2018-06-20" version="1">MPAAKIHTALTPKLISANFGRSPFCWNPLGPNQHVSRLWIPGVLFDSYKIFFLAATEWDIDGSSDKNANDSHDGRELRSFFKATMATGPIFPSVTLSHGFDAVRANFGQVPFRYPLERVVSDSVRTSQWPRLPREPSFPPEVVHAILAAVAPTDDERKTYAATCSLVCRYWARILSPYLFKTTKLQRKGDADILSILIEQPKCLIPTFLTSLTIQERACDAWAYSVAMLLAHRLPNLQNLILERDPLSPLQWKEVQRSMPPSISRSLPALYSAYKGVTTLTLVNHHFPSFATFTQLVSVLPVLKSLQCNCVTWGERPNNPRLLRAPGRLSTIQMQKCEGYWQMIQLFTARWGRLPLDWEPSSKCPELNYNDSLLIHALLNFKHTLSPPVSEYTLKALFTSSTERRTWCLNIVLMHGSQEKVITWDLVFSPCVFHWQDGLIRTCLTDLRINTINSLDNFEKWILPLDEQFSKAPLPFLANVTITFSGTSHNIATVKRSDVLSKLSHLQRALNLQIPPWVDENIGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ27</accession>
    <name>A0A2R6NQ27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ27"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ27"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="11306" checksum="A3857B502977115B" modified="2018-06-20" version="1">MALPSENPVLAANLQLVLSRAPGYDTAIDALRKAILGVAATHQSYLFSRSGVSSMADDAMQMAKSYRSESKQLLAEACATAEGMQSDASLAASVAIALLDVSPVELQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQZ1</accession>
    <name>A0A2R6NQZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR75002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQZ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQZ1"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="407" mass="44394" checksum="B251E8D0972A4463" modified="2018-06-20" version="1">MSGKEFENVAAPNTPYFTPAQIPASGTAVDPQPNGKPIPKLFQPIKIRGLEFHNRIWASCLELYCFVFGKLKLGGIISRGPGLAFFEATGVTPEGRISPEDLGIWSDEHIPAFADIITFAHSQNQKIGIQLCHAGRKASTVAPWMSFHATSTEELDGWPNDVVAPSAIIHSLGFPTPNELTKEGIQGIKKAFLDAARRAVKAGIDVIEIHGAHGYLLHQFVSQVSNNRTDEYGGSFENRIRLPIEIVDAVRTVIPENIPLFYRISATDRLEDVFPGEPSWTISDSIELAKILAQHGVDVLDVSSAGNHPKQHLPPRGTEAFHTDLSGPIKAAVGDKLIVATVGGINSGKVAQRVLDDEEADVVFVGRHFLKNPGTVWEFAEELGVHIRIAHQIEWAFFGRGVGHPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRE8</accession>
    <name>A0A2R6NRE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v9250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000917">
        <property type="protein sequence ID" value="PSR75209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRE8"/>
    <dbReference type="STRING" id="98765.A0A2R6NRE8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR75209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36577" checksum="C21AE973B284CFB9" modified="2018-06-20" version="1">MSLIPLILKDAENWGNHMEKFAASSVLCATYGWSLFDSTDRDQTLERITALNRRISHAVVPGNFLVNVFPVLMHLPVWFPGTRWKREGLELNKRVDQLFVELVNDVEIKLNEDGKVEHCLTAKLIENEGKYGLDRKETAWLAGVMFAAGAETTTGTLCTFILAMTLHPDVQRRAHAELDSIVGRDRAPSFEDKQNLPYIDAVVKEVLRWRPAAPIRTTIFENIWAISHNPELFPDPEEFRPSRFLTEQVELSDQIDSEVQAGVDKLFAFGCGRRICPGQHLAYNSLFITISTLLWAFDIGQTTDYNGSPIVPERTAFVDTGLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSM2</accession>
    <name>A0A2R6NSM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v8828</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSM2"/>
    <dbReference type="STRING" id="98765.A0A2R6NSM2"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="327"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="751"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR75914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="788" mass="86089" checksum="D0FAEA0E6FA3CF85" modified="2018-06-20" version="1">MIPRSLRASALPGRRIAHISRTGWAQSSIRALATPSHPPPNNERKPEKDGEQEKGKEVGKEDGSTPTEGKQEGKQESLKGLEGFFRRYHQQQNDSKDQSSNKNEKEPNKSPPPPGGSGNNGLNTNQLALLAATAAGFYALSNTTSLGSREITWQEFRTAFLDKGLVDKLVVVNRNKVRVKLHSNATGTMYPSSTSGGGDYYFSIGSVEAFERKLDDAQRELGIPSHERIPVAYHEEVSNMSHLMNFGPTLLVIGMFYFFSRRAAGGGGSSGGIFSMGKSQAKMFNKDTDVKVKFADVAGMDEAKEEIMEFVSFLKNPAKYEKLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFFSVSGSEFVEMFVGVGSSRVRDLFATAKKNAPCIVFVDEIDAIGKARGRKGGIGANDERENTLNQLLVEMDGFGTQEHVVVLAGTNRADVLDPALMRPGRFDRHITVDRPDVGGRKAIFLVHLQPIHLSDKLPEREAFAQKLAVLTAGFSGADIANICNEAALHAARKLHEAVEESDFEAAIDRVMVGLERKSRILGPKEKKIVAYHEAGHAICGWFLEHASPLVKVSIIPHGSGILGYASYLPPDTFLSSHPQLIDIMCVSLGGRVSEEIFFGIENVTTGAQDDLRKVTQLAFAVVADYGFNEVVGPVSYPRGDFGQKPWSEKTGEMLDSEVRKMINAARQRTMELLTKHKEDIERVAQLLIKQESITREDMIKLVGKRPFPGRQDDMDRWLDENSLLRGTPPPLEDVNPETPLHPSPAATTVRVSKGPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSM9</accession>
    <name>A0A2R6NSM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSM9"/>
    <dbReference type="STRING" id="98765.A0A2R6NSM9"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="135"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="526" mass="58510" checksum="AFBC602356897FAA" modified="2018-06-20" version="1">MPLRTHLAALDATASLYPSRPVFKVPKLASPGSDEIEEWSSISYSQFKSDVDLYAKYWARTLAADGLPPRTTVGLWYVPSSAGYIPQLFSLRLPNPDVVYELLQRAHAKALIYEPSFANTVSDCPLPTHVALEVREEDVEGAVLPPREDPVNGDDIVVIFHTSGSTSGSPKLVPCNYTWLDAMISKAYHTTKPKNTGRQDVSVWMGSMCHIAQNFMLFGSIQHGSCTVQPTKIAFSSDELIDMVTRCGLNRLNQFATFLATQLRNSHHNPKLLGVLQNLDEVVYSGLMLPPDDERWAYDKEILLRNLFGNTECGAMLLSVGGRGADTRLLQPIEGTDYGFFPLSSASENKSEHVDANSQLLELVILSSSPDCPDRSLRNADGHYHTGDLFLELKPGHYIARGRDDDWIKSENSLRCDTKAIEDNVRATCGDLVSDCIVVGNGRPSPALFVEPKVDVSPEVLKRDIIRRIRHFHSRRYLHERITSAEFIFVVAKGTLPRTATKGNIRRKAVEEAYRAELDAVFGMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSP7</accession>
    <name>A0A2R6NSP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSP7"/>
    <dbReference type="OrthoDB" id="3205299at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="27751" checksum="197E019CE53D4D07" modified="2018-06-20" version="1">MSLNRSKSTPEVAPPQPFLRQDIPAKNRGRPQMHRQRSESALSDVRQSIPSPPRHYRPARERRTEDPFSLAGFFPSETLFAPSQHFDSDSEEPWLWLQEYEGAGERDIENSSPVLLPLADFPVQGSSSSHILAKTEDTDFEWDDAIRQEDKLGILSMPSLFVYAGSEAEQPYEHLLSPYSENDADPPDSEGLYQVLHALRQAHSTTENAKNATTHGLFSPADVEIFGPEEEVGWQSVFGVLLDVLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTQ3</accession>
    <name>A0A2R6NTQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000846">
        <property type="protein sequence ID" value="PSR76434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NTQ3"/>
    <dbReference type="OrthoDB" id="3169018at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="895" mass="100232" checksum="A5836948E20B1675" modified="2018-06-20" version="1" fragment="single">IYPALADSLANAASDSGASILGNTIFAIRQDGGVIQTCGQEWRFLIANLRSMVRNVDVPTTVLLHSATPHDDSANMSNSIVAQQQQGFRHFLLSGQGSRRSRFHIRHQRPCFTHLNLQSDSSLNIALDGGIYESCISAPAEYSQLDIVDLFAQLGEEFLAQSSEGNPADLDTAIFFCWLAVNTSYDDQSRYLSSLHDLARILMERFQRLHSPYDMRQTIYLIQVAYKICKEDPALANFLLADLAKWLYIGYTFLGVVDDLDEALEWCRRAIVASPLSDRHSLHFLANACGTRFELVKSGANIDEAIELARRVIALCPLDEPERFKYMHNLASHLHFRFLYLGAARDLEEAIQIYHQVLELNTREFGGNDREASLFGLSSVLGTSYKHFRKLDDLSEGIRLQREALSLSPLGHPGRYHSLAMLAAFLDFRFQHLGILNDSDEAISLHREAITLSPRDRLHHPSLLCQFASILCLRGVQPPGDFGLLNEAIQVSQYALGIAEQRKDREAALYQLTRSYLGRFKILGQIDDETAALNAAKELMEIGEKYSYQGRSPYLIALAGIYLRRDSPFFDLSTGLRLVEISLEDTHCSAQLRLQNASDALGVLKSVSIDVPTIHQLLRVYLKATLLLPEVAHFGLDLKSRLKSLKGWGGMANYVATLLSAISRHAEAVQAIELGRAVFWSQAVQLRNKFDELPEELHHRLFNLSRQLERDSYSLPKVVSQNPTPDVDSHVDNARRLRYSQDFDRLVQEVRERPGFERFMQMELAVDLAKVAEKGPVVVLIADANICLAQIITAKSKDESNVLPIKLDVTQQALRQMAVALRSATAGRSGRQDAEDASLGADDQSEGIEEPDSDVTRLGRPSKAGTQDVRILKILWEKVVKVVLDALEIQVSRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTT1</accession>
    <name>A0A2R6NTT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTT1"/>
    <dbReference type="OrthoDB" id="2736021at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="15467" checksum="0B9E0C0002D747D8" modified="2018-06-20" version="1">MGYRNRGGVKPVASCWLEPPEDEAGIAEWEEMMRRMEDITTSTFDLDVSDTYFLSPKCEDRPRLLRVLWRSKHPIPERNRGRRRLPVFNKMGKNVPPRDLSEVPFGESVRVLFEVSYSRGAVYGELLKLAVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTX0</accession>
    <name>A0A2R6NTX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTX0"/>
    <dbReference type="OrthoDB" id="3220023at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16537" checksum="9C0862DFA3A2AFE5" modified="2018-06-20" version="1">MVDNPAKSSGPQQGSSDSNQISTTQRSKKRFKRDNERTQREDPPRCHLNTIPLEILAEILSYTTPRDILALARSNKFFCATFANNPSSTFIWKRSRADFNPNAIPDPTPNFTEASYAAFLFDPGECEVRVHLFVLAKLNLALSYIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV96</accession>
    <name>A0A2R6NV96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV96"/>
    <dbReference type="STRING" id="98765.A0A2R6NV96"/>
    <dbReference type="OrthoDB" id="3034442at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="499" mass="55109" checksum="D32D326D4DA50263" modified="2018-06-20" version="1">MAGVGSTSQTKRIAKQVCKRLRAISRLRIVWTRALASHVLEQGFPFSDHIDVNSIDCSELEYRTRRAYQLGQFWLDQKAIPRELAAWTAGNSATGVSDVRFSPGHPDWLFTVSKGIWSMITCWELGGRGDHYKRTRQLAEWSPRQTLITGIAVNSDPGSEACLAVAGRQEIEILTVREVEGEDRFAFHTLQTISTPFRVMSLHGDMLASSDDVNETHVHNWRTGDYAVLWGSNEPSEHNFQVVLTPNCVFVVRARSFEVFPELLLSPSNQMSVSGYTHPICRHQFGWIDGVAMSSQKAIQPPATSTPPFSIVLRAESDDPWSSDVHTLDLFDLEPNPNYGGHPAHPSISHDTVSYPPVSDDDAKLPGSAYIFPPLHRTSWRSARGHLRCTDILLGSHGTAIWVLPRPARNLDLTALDVHASDTQGPGGDSTREALVAAILPGHFKDNRQCVPGPDNATDVRTLCTYEGTSGNWTSVDYDEPGGRIALGDSQGKVRVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVH4</accession>
    <name>A0A2R6NVH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate esterase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVH4"/>
    <dbReference type="STRING" id="98765.A0A2R6NVH4"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF85">
        <property type="entry name" value="A, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015313817" description="Carbohydrate esterase family 16 protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31821" checksum="BBFD0E7CE0551C19" modified="2018-06-20" version="1">MFSSFWPVVFAISAATIASSKLTWGTTEFLFTFGDSYTTDGFNISAGVDSPVPGFTSSNGPNWVEFLGGTYNITNTQVFNLASGGATIDAALVTPFEPTVLSIVDQVSQFKTILAPKPNGAKWSSSNSLFAIWIGINDVGNSFSWTNVTQSGFHRVLMNRLFSQVEILYEGGARSFLFLTVPPTNRAPLLIEQGNAATTQISAALADYNAQLASSIKSFEATHRDLDQVTLFDSRPIFNTLLDNASPLGFVNSTGFCEAYQNGTPETNTQTAPCAPVSSYFWLNTLHPLFTVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVM9</accession>
    <name>A0A2R6NVM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVM9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="8298" checksum="4E993C25A413F23F" modified="2018-06-20" version="1">MGEFSLSCLLRMYNTKRISYMQTLTTVGISDRLHDWWNLQYTINRMARPSTPEVLPRHMLSHEALTREQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWJ5</accession>
    <name>A0A2R6NWJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000754">
        <property type="protein sequence ID" value="PSR78236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWJ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWJ5"/>
    <dbReference type="OrthoDB" id="2731295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="123"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="266" mass="30469" checksum="C088B5D25E0FBF89" modified="2018-06-20" version="1">MVPVITYGMQLWWHSNLKNVKWHMAESANVQAKAARWIIGGFRTTLTGALNALAGLPPIKGRSRHLMNKAALRVHKLLDKEFPNRIKFCLLHPLKSKKKEFENWYEKTFVPKLHSLMWGFERKKVIYIVFTDGSAKKTVQTDKPTRYRSSSSYLVLKQSLENNRHVKYATLASRKTTSYDAEVMALAAGIKNAIRAGGTNLRKLHIFTDNQTALRDIVKPGCYSGQMFTLSMIKDLRRFLCKSLEHSITLHWCPAHVGVPQNKFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWT2</accession>
    <name>A0A2R6NWT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWT2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="7949" checksum="4E22F9F202F640A0" modified="2018-06-20" version="1">MSEELMDGATLPVTEGAEVNVAEDALNTELGRKMIIEAELEGTDREVCTADVTAIGPLLLASVPVNVGLLRKIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX73</accession>
    <name>A0A2R6NX73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v7189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX73"/>
    <dbReference type="STRING" id="98765.A0A2R6NX73"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR79002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="280" mass="31758" checksum="25348E17AADF0380" modified="2018-06-20" version="1">MADLVDSMLDLMRRLPPTHVEANVAALVGMCPDYADDLLGSVDQPLKVMVDRATGREYLACDYNRDGESYRSPWSNEYDPPLDDGTIPSPKIRKLEITANEAFDTYREMYYEGGVSSVFLWDLEDGGFAGVVLLKKSLNPSSPSEPSGSWDSIHVFETAERGRQAHYKLTSTIMLSMMHHPAKGKKGDEKVEATRDGDVTLSGSMTRQTEQDHSLQEQTSHITNIGRMIEDMEIKMRNLLQEVYFGKTRDVVFDLRSLDDLEKARRQRELQKELVGFIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYV1</accession>
    <name>A0A2R6NYV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYV1"/>
    <dbReference type="STRING" id="98765.A0A2R6NYV1"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="78"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR80720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="395" mass="43860" checksum="7ECED1E1A2E2F5DD" modified="2018-06-20" version="1">MGSLEMHSSVVEDPVELIFLGTGTSSSLPHVDCLTAPPGAKPCRTCLSTLHPEGKKNIRRNTSVAIRLPGQDGQKVTIVIDVGKSFQTAAVEWFPKYGLRRIDAVLITHAHADAMNGLDDLRGWTLRSAIQPHVDLYVTSHTFREVQRAFPYLVSKEFASGGGDVPEFKWHIIDDRVPFEIEGTGIQITPFAVHHGRFFSSAPPLEFCPTPSSLSPASTTPSTPPEVPGTPRYPDVMPEITNKIRPYFCLGFIIQDAVVYLSDVSHIPEDVWSLFKRSADDDRRSPVPPVFVLDCLRLQSHTSHLGLADAVEVARRMGAQRTYLTGFGHEVSHEEYVTIGEVLGGKQKEEERLTAVERQGLQLIEAGEDLWVRPAFDGLRVFVSEDLTVRDEEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYY2</accession>
    <name>A0A2R6NYY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000637">
        <property type="protein sequence ID" value="PSR80856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYY2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6177" checksum="752C6EB043475AB2" modified="2018-06-20" version="1">MNANRIEVAAISHIYATHQVKQPQLEEAVPCPSGGQGSLPVHSFSGYPRTPSMSKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ19</accession>
    <name>A0A2R6NZ19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000629">
        <property type="protein sequence ID" value="PSR81015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ19"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015354282" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="13430" checksum="6F35D71CF3285996" modified="2018-06-20" version="1">MLSSKSFILLAVALGAFSNVSNAVAVADVVERDLATRAAEGGAGATCSDWFISGSNLQALCTRADGVVAASAIAISTCVRNTNGQLNCGLGGGAGNSCTFFNLEASNGNSVIDISAECTKDDGTQSSQINFNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ44</accession>
    <name>A0A2R6NZ44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000627">
        <property type="protein sequence ID" value="PSR81064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ44"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8382" checksum="2091FDF0D49E6335" modified="2018-06-20" version="1">MGGSSLDQNPPNADRHITAGGSDWLWAVFAVMILSDLGMIFWSFTASILTRLFTLPLELIVSSSGREAHAYSTILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ67</accession>
    <name>A0A2R6NZ67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ67"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ67"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="15"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR81133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="202" mass="22345" checksum="C6E808D19BAB3BD0" modified="2018-06-20" version="1">MAFIAERERTPGFTHVVLIVTGSVASIKAPLIVSELLSYPQVKVEVVSTKASRSFFDTEKVVNSGVRVWKDEDEWPEEYRIGDPILHIELRRWADVVLIAPCDANTLAKVANGICDNLATSLLRALAPTTPTYVFPAMNTLMYEHPLTDVHLRIVRDTIGYTVVGPIGKTLACGDVGLGAMTEWRDVVQIVANKFSLHKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZZ9</accession>
    <name>A0A2R6NZZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZZ9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="14646" checksum="E5A06DD08417D2B3" modified="2018-06-20" version="1">MLQAQGIIQLESTAGLGGTKRGGRVSPASSDAENRQRPLKRQRYDPAVNASQDTASQSNISQAPLSQDVIKPIVKPEDVADLDYLEAHYAAAMENVKELAAKLQQAKSQTRLIKREHSPIRLGGSNRVVIDLTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P054</accession>
    <name>A0A2R6P054_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR82006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P054"/>
    <dbReference type="STRING" id="98765.A0A2R6P054"/>
    <dbReference type="OrthoDB" id="2792537at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR82006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="490" mass="55044" checksum="7355A517362D8A7A" modified="2018-06-20" version="1">MPMPRTGPIADTLRSPYWSSTAERITRVASLIIEQHADVNLGQFGRTPLSLATEIGNWKLVELLLRHGAHRPPIANLSFATLTDKSLYLALVKKVKPTTPRPPQPCPCWSGQLLSKCHGQNSQPYPADFLCRCGRHKTYRNCCAKRAFKMEEEWDQDNECISTVEVRKLSVPEVPVEFAEDFDAGGQVFREGLAQIQSDPELCREMLEKLAATKAKFFGDALGDEVDPAYAFASNSNDFFPRPWAGQISKQECKIRMDEWNKAVDQYIALGKDKRAKSQIELEAKIEMSGGPLYRCCEASDCPRVEGRDVEKMKCCSACKLLQIFPNRAYEMMDALMQQYPTQIEHQGHPFLPTHLLDSFDSDPPLSSWVSIIHTKSLEKFRFEVIAQRIHCNAGIQTSAVECPPLIASRVPKEITESLYRFRSGDGKTFLHLAATSGDVPLAYEIIRMGADVDFKDKEGVTPLFLASEQFVFLDIAIEFAKGVTPCRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P113</accession>
    <name>A0A2R6P113_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P113"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6612" checksum="50C91F5A605C1747" modified="2018-06-20" version="1">MNDRELADFAREHGLDIGEYEDNYVDDSYSGYAQAVQPHYYSDDIDEYSDDIGIQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P190</accession>
    <name>A0A2R6P190_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P190"/>
    <dbReference type="STRING" id="98765.A0A2R6P190"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="78"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="700"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="833"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR83143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="872" mass="99244" checksum="77F83EDAB7CAC63F" modified="2018-06-20" version="1">MSEPMLRNGSSELASDTASLGDPDKTQPTQDILDVLRQLSTSQQTIPNSQSSENLQQHSQVIEPAASQQDPPPSEWDLLRAQVREKPADSEKWLKLVEVAEDSGDFERINETYEALLEAYPNTSSAQIAYINHILDSASPSKYQYAEGLFKRFLKTSPFVDLWKYYLSYVRKMNSGPNTRETVRKAYEFALNHIGQDKEATEIWTDYIQFLKAGESATTWDDGHKMDSVRKAYQRAVQIPMDNVKRIWEEYQEFENNLNKITAKKFISDLSVAHMQARTVLNQLQEHLTVLFPPLPPPKVKGPSIYIPRATTFSAGEKALVGRWRIYLKWEESNPLELEEKDRATLQTRIQGVYRKAVVRMRFFSEIWYMAYVWNINQSNDPSLLEAKRKDKKDEALSLLERGIEANPASFLLNFAYAEAQEASKSFGDVHTSFTKFLEVLRKELDELESRVNFSPPSSQESAVAVDRTDAPVGWPNAGSASQNSSFNSQTSDGQPPKNKELVERRTEYGLAWIVYMRFARRAENLKSARAIFGKSRRDRWTPWQVYEAAALMEYHCTKATDVAMRIFEKGLENFSDEAEFALKYLGFLISINDDSNARALFERAVNSFSPERARPIWERWARYEYQFGNLEAAQILEKRMSDAYPNDPPIKRFAARHEYLGTDAIAHRDLGFVRGSSTGSSRSTNGVARTDTQQSLLANISPPSSQQQISGSVVKRPSSPEPRRRDEGRGGSEYGPPSKRQRGGSPTRSHDRERWDGPQRRRPFDPSASWSDRDRSRDGPPMRRHDKDREEDKGFVLPPVLSYFVGQLPPPANFDGPIFRTDDLMQVFRNAVIPSSTGIRPRSPPHRGGGRPPPDYSPYTGPGGSGRRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P199</accession>
    <name>A0A2R6P199_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4921</name>
        <name evidence="4" type="ORF">PHLCEN_2v5813</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000498">
        <property type="protein sequence ID" value="PSR90359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P199"/>
    <dbReference type="STRING" id="98765.A0A2R6P199"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="HD-associated" evidence="3">
        <location>
            <begin position="220"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR83164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR90359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="588" mass="66819" checksum="9C4908C92F974355" modified="2018-06-20" version="1">MNSLISDLQPTPVRTSELHLAVIKVSYNSTTTKLAGLGEVPPQMRERNFKDSVHQWSVAHLAQMQIKFLQKQQPELDITDEDVECVTIAGLCHDLGHGPWSHVWDSLFIPKALPHKKWRHEDASEMMFDDLIKEDHVTVSEREAIIIKALISGDSSRCEQVFILVSFHRVPNTSCFRGMNVKSFLFEIVANKRNGLDVDKFDYIARDQYAIGQGENVSLGKLIRSARVINGQICYDIKDANTVYELCWSRFSLHKRIYNHKTAKAIEYMIIDALLSAEPHMRIAEHIDDPKKFVFLTDDIKTRIEMTTEPELAEARTLFRRINIRDLYKCVDYKVFPWKLKDICRQHITAEAIVEAAKKAPFATCDPQVIDGFDPEQVDAQDVGPADPQTVEALDPKHVIIDMAEMHYGMKEKNPLNYVQFYSKYNSVSRPANAGDISNIMPASFGEILLRVYTRDARFHGVIQMGFHRVLADLESSSKEADEEQQDVEELDALDLDVLTADTVPAPATPRAFTRTLSRAVSARQALHIVSPNTTPFAPNQFTKVPPSFSSSAKQNSPTMEQRKLRSVKRERDERPGSPPRKRNKMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1B0</accession>
    <name>A0A2R6P1B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v369</name>
        <name evidence="1" type="ORF">PHLCEN_2v5828</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000031">
        <property type="protein sequence ID" value="PSS37768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1B0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="13833" checksum="D30B3B4A214B3D3D" modified="2018-06-20" version="1">MSESRRFSTNFRALFFRDEFVWEEKFEKGYHIRPNRTLLDSGEWRENVPPSTGKSCCLIENISGQWFYLGVYQCEAVEQLDAQGFALLPVKLRLPRIAPAQKRRTRKTAGKIMTKAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1M5</accession>
    <name>A0A2R6P1M5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000557">
        <property type="protein sequence ID" value="PSR83541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1M5"/>
    <dbReference type="STRING" id="98765.A0A2R6P1M5"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR83541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114503" checksum="168F9FD752127D67" modified="2018-06-20" version="1">MRSQFTLSELNRLWAAYAQTAEFSSARGEVFKTKFLDGMHQIAREHKDKDITTGCRSAGPLYVESYSIVSEAHRQYWNTGITSSDSHPPAQTNNVNPTFAYATRGEGFVAHYGTAPLPAFHLAPAFASSTPRTPTIAQVYDVAREQFQAWCGTFRSCVRSTGGTTVVLRLVVGDVLAVCHTLHNALSTNSTTAHHCISAWNSTFLELDGDEEVSPSRYNVIDTSNLCDHIGMLNVLVAATPLLTRTPSATLYTESLLASGEDPTVALSDSLCGDIMTMSALLDLIPLSLASGFSTQSNVHEILFLSVNDGRQYHERINWKIPSLLNGDPYMGNIAVDDPACLARLLFNVYLKMFAHEDMGPLLQKISLRALRDRSSVHYCRGSFALFVAYLKNRIRTDWTRTIDALLSFIVCDRQLLIGSNFYQDLLCHLNMLNIYSEQPFSPNNPLRIESKAQGPFSDWSNVPPVVCVVMEIPPNNMHILDDTSEGANPVLFAGLRGPNFFNIFASFQAGFGKITCQGSGENSRIYPIEESSRQDSTSPIVISFCVPAWMLSISPRNTSVVLAVQSTPATTRQWAPKLGMEMLLFSARLMDTNSVHVVPLTGAGPSILSTPPRYITREAPCATPSNITSVIIDEAGKSIKYVKIRADIVDKAKDDLSNVKTEVSVTQACQTGLELKIGLSTAQRLEAPFPVNASRSKLRVARKSSWVEVLAPPPPAIGTLPGNPFPVLFHSASHTQMMPWNIHSTNLERLPMLDLSKVDNMAAMPWMSLHLSSMMSDRERKMRQSQRAQGSDVLVQVKDSIHFIIMKSCKSEVSVFGLSNQLSGHIDTLIFVTGIRMDLGSHTVVADAFVLSLTKTLIQKLGTSLEAIFSTIIQDPVSDQETIAWKCLLPAFVERCRDWEHKAKCAYIQSGMIPISTQHGENPICDCGKGKVSPSFTRNKQWAAFVPYVTRIAVSPLFAVSYLETIGEHYKDAVREANTGVAKQRPASHAAGSYQCAGCKTSVAEGKALRCSACKNATYCGRECQKSDWKKHKIVCKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1V1</accession>
    <name>A0A2R6P1V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000551">
        <property type="protein sequence ID" value="PSR83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1V1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="14144" checksum="21BD8C156DF4F67F" modified="2018-06-20" version="1">MSKWVTVNIVKNPYKAQDEIEAAYVEKNFPDNITDPFPYKFKPGDRALARVKDAGECWQNVKVIEVTRLDETTYQGWCVWEVKADWKALDGTRMAPRNFYPARDGDIKPYSTTMASLAYKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCF4</accession>
    <name>A0A2R6PCF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR89000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCF4"/>
    <dbReference type="OrthoDB" id="3146826at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="15471" checksum="CFE048B36838411F" modified="2018-06-20" version="1">MSTSRSPYKLPPGERDADKVTYNPMADDRVDSDEFDPEEDTERQPIGARGADNEPTRRHFAKEDMETARSDATGRIPKSEVAELVSSAGEDTSGLNPSGTRGIRVDAWKQDKEMDKMYVESGLADAVQDVEIKRGTGYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG39</accession>
    <name>A0A2R6PG39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4821</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PG39"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="489"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1224"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR90672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1860" mass="210439" checksum="7F12D343C8C46213" modified="2018-06-20" version="1" fragment="single">MDRTNSFTGGQRPASTSGAPFAYQQRLLERTSSTRGGSGSLSRASSQSSNALLSSPTGTPSIRRWTPSHRVGGSLDMVRGKWEERLKSEGVPESPSRTPSDETGEGLRSSTTYGLDSPRTPDDGARTRFTDPYTHIPKRSDSPEFSYTSTPTALKRHTLPAPIIAAALSPNNTGVTVENPDSPTSPYSTPTPRIHFPVTSPTDLRSGLVTKRASHYSIPIHDEEPEFSSVRLRRSNTLESIQASSTGSSTASDATSSTSVTSTSSRTFQSDASSSNGISRRTSSLYGNHRPTLSSPSPSQDKHTISRARSSTTSNSSVSPAKVSGSDPPAPSSSRVSDAMSPKPYRSSYMNKKASTYGETLIVGRRLGRHLPRIASGDAPEDWEEEPKADTKADEGPPPEPPETWRIRVAERERRSQEWRSPSPEKPRRRAPSFPTAGNPDDVAGIPGRMRLSRDKTPSAPSSPLPSARLSRGLWADVQRHLLQAYEYLCHVGEAQQWIEGCLGEELGFGVVEMEERMRNGVVLAKLVRVFQGEAVVRRIYEAPKLDFRHSDNVNVFFNFVRHVGLPESFTFELTDLYEKKNFPKVIYCIHALSHLLARRGLAERIGNLVGHLQFSDDQLQQTQKGLKDSGVAMPNFGNVGKELAKEINEEPEEEPETEDERRDRLLMDNEDSIVAAQAAARAFLVRKAQATQRGRIQFAERYVPGIQARARGVLFRRQMERERSERADMRDWVVVLQARARGAILRREWASHLRGIDASEDYVIKTQAQARGVLQRRKYLRIKAAMRSYTVSVVKLQSLVRARIAQQSHKEVTKNFMQPVITSAIVAVQALARGILLRRKIHTRFAVLDQVVPSIVLLQAQARGVLIRRRVGSQLAKLDDVSDVVVRIQTAVRTFLVRKRLLALIRGLRNATPGVIALQATARAALAKRRFMAKRNAFREVKIVTSVGGLQAFARAAITRNRHREQTKRLEFVQPDVVGIQAVARGVLARMEYIPWRDHIRRSHPVATMLQALLRGVTQRRRFRARIEHYRSNLDKVIQIQSLFRAKETREQYRQLTVGTNVTVGTIKNFVHLLDDSESDFQEEIKVERLRQSVVKRIRENQALESHVDDLDVKIALVVQNVKSFEELLKARRRYGTDSAALHAARASILAAHGDPFAGPSTLDHSAKRKHELYQQLFYLLQTRGEYIARLFTRIKGDDGGEKTRKTAERVVLTLFGYGHDRREEYLLLKLFQTAIRDEILTAGSIQEVTNAHPMFITIAVKYVRPKQTVYVRETLQAVINELKDGKDISLESDPVAIYRTRIDVEEMRSGAPSPKPKDVTFREALQDPDTRGEYIRHLQLLQWWTEAFVTALTQSTQRMPYGIRHMARETLVALRDRFPDAPEEVYTGCIARLLFYRYINPAIMTPETFDVVSQTLDTPTRKNLNQISRMLEQITLGCEFGDENPCFVPVNDYVRKAAKQWSSWLLEVANVQDAESQYHAHEFLDATAQPKSIWISPNEVYTMHSLLSQHLDHLAPQRDDGLRIILTDLDGVPHIGDDELNDARDAAIELPLTNRFADVKDPNADLKALWVQAKRAVLAILRVQPAKDLVESLMQPVTEEHEQTWDGILTEMTREQKHQRRMPSTTHVDSAYRLEDIRSMTFREVKAHAIFFLLELEKRGQISRIDGYQGILNAIAGDVRSKNRRRIQRQHEKESMEEALTDLAGRKKWFEEQIKSYHNYVETAMSTMQRGKGKKRFIMPFTKQYFHTRELQKAGKTPQFGSYKYSAQHFYDKGILLSIDQYSPRQFDKIDIVLSSNKVGIFTVEVFNNALGITNRVAHADVKMEDLLVAQFENRASYPLFNGMAKFNLNLLLWQINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG90</accession>
    <name>A0A2R6PG90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000492">
        <property type="protein sequence ID" value="PSR90760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG90"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8337" checksum="D2A69E81B65E2E69" modified="2018-06-20" version="1" fragment="single">LQEAFAIFNRPLQTNRVPHCTRIAQPVQPVHNTIFDTHLHLHLHFDLNVTVRVLACVEGLILLKLAHKWGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ73</accession>
    <name>A0A2R6PJ73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000480">
        <property type="protein sequence ID" value="PSR92130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ73"/>
    <dbReference type="STRING" id="98765.A0A2R6PJ73"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR92130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116070" checksum="169F5324237A8E49" modified="2018-06-20" version="1">MVLDLLQPAPDHPNDTARIQAMPKNHPNGPALPVSGDASPPLLRLPVDLGLHPTHAPELDDLPHLELAPAAADSEFDEPPLALGVPETDRLDENDTIDVGFDDSVWDVDRTILHGVDNAELDDASRAGLDLGSLADIDQPLPMAGNRTLPDDADLQPLPELRIDELQISQAFIDALQGASLDDEKLHPDVLERLRNPPTEEYKLDDPALHLSLEIFLGLDRASEAHYDLVRGAVSRSHSIEMLTLHQVKRAVQDISGVRAVYDDMCISSCVAYTGPFALLESCPTCGEHRYDQLKLLHKKVKHPRQRMLTNVIGPQLQAMWRTPAGAKAMKYRAECTKKMMETIELTANGQTLNIPDYADYIHGSEYIDAVTRGDIQESDTVLMLSIDGAQLYRSKQSDCWIYIWVNYNRAPDNRYKMASISVGGVIPGPEKPGNLESFLFAGIHHVHALMTEGLKIWDADTLQTFTSRLFFAFLTADGPGMSAVNGLVGHSGAQHCRLYCGMKGRLKPGSGIYYPVCLLPFEYNQPGSTHPDVDIFQLSIQDRAEVTRTYRRNLRHVQESHNPNQYRIRRLATGIVKPTILSALPSNRIFPIPGCFPADLMHLAALNLPDLLLSLWRGTMTCEKPDNRDTWDWAVLRDLPTWRTHGREVAAATPYLPTSFDRPPRNPAEKINSGYKAVEFLTYIFVLGPGLFYGLLPMNYWLHFCKLVRGLRITHQHTIPNSHLSEAHTFLIEFLQEFEVMYCQRMVARMHFCRPALHALAHICPQTTSTGPYAIYSQWPMERSIGDLGGQIRQPSNPYGNLAQRGLRRCQVNAIRAIIPALGDQRPHLPRGAIDLGGGYVLLTTSERYAHMVTEPEAVALRTFLHESNALVDKAWLRTPKLARWARLQLPNGQIARSHWQERTKPLERLRKGRNVKMNIQGKTEFAEVQYYFKAALHNNNVEQGFAMVSVYAPPDTELLKLSNQTLWSCEYTGDKSLCVVTVQSIQSVVAMVPHPHMADETLQRKLSGRVYVGEKMGLDMMYFAGHVDDPVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ92</accession>
    <name>A0A2R6PJ92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ92"/>
    <dbReference type="STRING" id="98765.A0A2R6PJ92"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR92242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="584" mass="65666" checksum="EF66A2407EE9B599" modified="2018-06-20" version="1" fragment="single">MFNLRLLSTLPLSIKRLARPRRHKDAAQKNQISVQTAIGIFDIMYIILEGLDNKDVASCALVCRDWAAIVHEVMWRGRSDSGVGIRPILGLLPEYYEESRNARFRVAPNPASWDRFNTPEYAGRISVLDLNIQNLRCTIGFLAVMSDSIKSPMHLPALNELHVTVCQDPVEFRIAMAFFSANVTHFVANIERGYPSATGHFSNQLDPHTSTVPTASPLDAFFDAVHQCMPHIRVLTVNVRDSEAMVDAFDPFVDMLCGLKELITLSLPPYMLGLSLVTALSTHQQLRNIVVIRQDPTRRTVMDSDDSYGIVTQPIFGPDELSTRLAELAVVVPADSFIPFFSHQFDPHNLTQLDLTFTGEIAVSNSLRTALFLIADRCGSLENLTVSLLQSCDNPWRLDYAALEPLRKCERLVSLVFTTRFTTDLDNNKFEDLVSHWPMLKHLILDGSDVVPASPDERLSLCLGTVMKIIRKHCPLLLKLQLHLSMVLQRHWFMDCTHFRCINSLTSVTLVMGSPATTPVSQIAVYLKWVLPPNCKLNYFPAVHDLSPRARLVEWKARRNAVVAFSQKLTRILAKLNCGVEPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJE4</accession>
    <name>A0A2R6PJE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJE4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR92240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="13565" checksum="A8C0F4427F1BA659" modified="2018-06-20" version="1">MTIRALLVINIAQIIVKSLPSSSGFSPVIAVSDALPPVLISRCLLNLWQAGQLEGDSSSATSHFTTLKFGSPNVVNTQVEFSSALDNTGDLDCDSEYGDKAVDWDGFDGILSDNIHGKENYSGVEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMT7</accession>
    <name>A0A2R6PMT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMT7"/>
    <dbReference type="OrthoDB" id="3153758at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="15285" checksum="F816AF40FD596B7F" modified="2018-06-20" version="1">MPLQSYGIDAAWPLCTGERRDEHKLLNTLQVPGRDPLDPAERERIRREWDKEIKGHDETRVKWNEENVFWEGESRKWSVWKQQIDHQRNEQERKLQAGKKNAPTGWDCYGTSLGTKGTVPHITHEDTLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMU3</accession>
    <name>A0A2R6PMU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v4608</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMU3"/>
    <dbReference type="STRING" id="98765.A0A2R6PMU3"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="116"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR93713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="268" mass="29524" checksum="DC0122F339E647D1" modified="2018-06-20" version="1">MTTVDNYEHLLPPSWKTQVTIWLQEDTPSFDYGGFVVGEALREAFLLGKGGQTAVLAGKPFFTEVFEQLGCEVEWHMQEGETFEPVKHVATVKGKARHILLGERVALNMLARCSGIATKSKRIHDLARGNGYKGVIAGTRKTTPGFRLVEKYGMLVGGIDPHRHDLSSMIMLKDNHIWSSGSITNAIKQARKVGGFSLLLEVEVGSETEADEAIDAGADIIMLDNIEGSELVGVATRLREKWNGKRKFLFESSGNITETNLHERAING</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMV8</accession>
    <name>A0A2R6PMV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMV8"/>
    <dbReference type="STRING" id="98765.A0A2R6PMV8"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="315"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR93740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41093" checksum="1C5C47ED5C17F2BF" modified="2018-06-20" version="1">MLEDQAQIIETTGAAHPPPGIDVVISVLNNVPSSLYLDATYIFRLLSNAEKFCTDGYICIVVAMDSESQVELKISDTGCGIPESFRGGLFEPYQQADSSLTRPRQGTGLGLSIVKQLVQSMSGTVDVESVEGEGSTFTVKLPVALPSLALPKPIVVLTVLSRLTVIYRQQRTARLFADLWGQYGLTTSLAALDVSFADLVEDADLIWADIETVSQSDALKHLMSVDLSIKLPTLFIVYSDALELAILQPALSSSTRVVLVKRPVVMHSLLEMLRKPEAYTNAHNAPGQVKGSFALPRPHEKKFLSAEPLPNGGHTILLVEDNMINQHLGKRLLEKLGYDVVAVSNGQEAVDRVVQQNFICCFMDCQACPRSLSLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVI4</accession>
    <name>A0A2R6PVI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000430">
        <property type="protein sequence ID" value="PSR97724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVI4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11720" checksum="93025561A32EC9CA" modified="2018-06-20" version="1">MPQDMRPMPANAEAKFKEFRAVGRRIMNQIEPTGAPPKFSIFAKDDEDMYSPKHAFKWSNAVTWMNAKPSKIVDGNNLPPFEAHIRSRSTTNEFGIRPVSVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PWD4</accession>
    <name>A0A2R6PWD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PWD4"/>
    <dbReference type="STRING" id="98765.A0A2R6PWD4"/>
    <dbReference type="OrthoDB" id="2665953at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="631" mass="69275" checksum="57B970CBA3CD656E" modified="2018-06-20" version="1">MQGTDEHGITSGGVMQMGGSPPSIPSALPTIRRNNQYRYDPDVFQGSTETSQRYPPPMGGSFALRRDVGAGRFRAHPDHYNAEDATSTVLAQLEEGRNSFHQLPTSRSEPYPFDAHEHQPHSYYSTSRRSSASSTGHDVEDGLYSSHFNRDRHPLLQRAYIPDIPPMGGTLSYRHHSESRASSSLSHRSAPSNTSQHSQALGIPQPGASHTAATYLHPSQSQQLQSFPNTTGLRVGTPILGRNDNVAANLAYASVPSFEHPIPALESCGLASLADDPLNDKPLHPGADLHAQSDTLSSTASHGDASGEADTSRPLAGVNRASIVPTSTRTDSGSSAEIRFNDKIQLAIRNESLPAEISLAVEPEPQEAGGTEPAYAERDVTPNVEEQGGKSIALRAGINVNATVDEEREDEIKDEIEDEVENEVENEVEDEIDDDDEPIAWKRRVTDENRRELIVELAAVDALFSDIAKKSGYSVEQVSSVYQAKNGNISMAPNYWNLYSIWFADHTLEECRRINPDTPDELINTTGISANDRSRCFSLFKKEYRDNYREILSAYHDVYVLSSAPQTLAKRVRTFRKLCDHFEMMAQSAHKQYGFEVAFVATGSSAHQDDKVGKVFESSGLSGVRIQKPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYW7</accession>
    <name>A0A2R6PYW7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYW7"/>
    <dbReference type="STRING" id="98765.A0A2R6PYW7"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="302"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR98923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="444" mass="48618" checksum="9C7F64573BCCC7E0" modified="2018-06-20" version="1">MFTTYDPAATFPFQPSEAANLEYSILSTILGNSPESSTGSPATVQAQVHSHTHPPRSNSYATQQSPTSLVNNGWPSDPQYQGTAASSNSYNSAGPSAYSEQQPLSIQPSDTTLNSSSRIATSNGYITPTTASFQQSSSQYATPGSGPSSAQGQDVQYSEYSNQSNQEQSSSTSLGQYNGQVAQPSQAVQLLQRQPVIPPTRSSSATLMDRTHSSGTASWVGPAASELGLIEGTSVYKSVTKPYDYTEGYHFLMKHISTRGFDKNDILRIVRALAIYRPSLIALQMPMSEEDEVFVEKCFQRSLVELDKLVSFSGTPTLAWRRTGEICLVGPEFCMLTGWEREELIGRKKYVYELFENQSVVEYWENFANHAFENTTQSVYSHCVLLKPSGAPVPCTFCFSIRRDIMDLPSLVIAWVSWLAILHGTKGCPASMYDVNASNAIDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7F3</accession>
    <name>A0A2R6Q7F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000388">
        <property type="protein sequence ID" value="PSS03330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7F3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7563" checksum="F292D920F52AEBBC" modified="2018-06-20" version="1">MLATISGIYDNWFSVISNTSSRRMSKGCCILDASPALEDLFFRNVSFGDNQWALGNKTRWTVAQVCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB30</accession>
    <name>A0A2R6QB30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000380">
        <property type="protein sequence ID" value="PSS05114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB30"/>
    <dbReference type="STRING" id="98765.A0A2R6QB30"/>
    <dbReference type="OrthoDB" id="3268967at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="203"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS05114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="440" mass="50142" checksum="B985B766D8BA5021" modified="2018-06-20" version="1" fragment="single">FIIAKNLQEYPVRVDLLGVPFTVFSDHRTLENFAEQKHLSRRQARWQEFLSQYDFKIVYILGKDNAPADAMSRKPQSSSPTRHPETTASILRVHPEPQWLETVKQGYSSDTWCTRLLSSLWDPVAQSAVGPNALGVTAEDALHRGWLNGRERYGVCVRAGLLYIGERLVIPRIAALREDVFALAHDALGHWGTEKSYAAIRASYYWPNMRKELETLYVPACPLPEDEGFNCILTITDRIGADLRIIPCRADLSAKELATLFFRHWYCKNGLPLEVVSDRDKLFMSKFWKALHRLTGVKLKMSTLFHPDTDGSSGRSNRTIIQALRYHVERNQKGWVRALPLVRFNHMNTINALTGFTPFQLLFGRHPRVILPLVSNPETNTPAETFDANKFLSRLDADVMEAQDNLLLAKSNQAYHADKSRGLEHVYKVGDKVLLSTFHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB67</accession>
    <name>A0A2R6QB67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB67"/>
    <dbReference type="STRING" id="98765.A0A2R6QB67"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS05378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="171" mass="18929" checksum="BF8B2E146F24D819" modified="2018-06-20" version="1">MAVRMVDPLDLDASFKSPLAWLRESLSLGVREKHSAEELAAARKEQAEKGQGSIFDSLDVAEEGKEDASTTASADGKKGLSMAEATRQSKKTWTEHKYSTANFKISHRKLNQLGRQIAGQPIDMAILQMMFSEKRASKRIKSMLVVAKDHAKNKGLEERKLIVGTWNSGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB87</accession>
    <name>A0A2R6QB87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB87"/>
    <dbReference type="OrthoDB" id="2801131at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="216" mass="23872" checksum="17690737166B5A30" modified="2018-06-20" version="1">MAELSDAKLPLPSFLKILTSNNVPASKAMAVTGKLYKTCNTPALLAELTDLKLKDIGVDDQEDRKLVLAAIRKAGYKPGLISSQRSSATRNTSADAGPSPRHSQPDMSNRRDAAPSQGSQRTKSKRKRDQDRNEFLPDRPREELEEQAYGSLDFSEVVDEETLKPKLVVINRAPIMTAWSFVVAERLGFQREEALSIGAHSSQCSFYTALGLWHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBH1</accession>
    <name>A0A2R6QBH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBH1"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="203" mass="21627" checksum="1145809B072206AD" modified="2018-06-20" version="1">MKSIKPAHADGGRIRRRNTSRKQSTSKVKKVAAKPVHPSATALSVSSTATPSTPDIPITLAADQKPNEQTSVSPARPRKQSKAPTQTPVVIACRACGQRDVPLMMGGRKYQPHTLFSTPDYCCAGFCRICIETSKAVDQVPAAPARQSVRSPTSNPMYIPSVTQPSPTSGSLSGPHMPSHGACLPSTPSQTQNLRYKTDQPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEY1</accession>
    <name>A0A2R6QEY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000348">
        <property type="protein sequence ID" value="PSS06877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEY1"/>
    <dbReference type="STRING" id="98765.A0A2R6QEY1"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS06877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="294" mass="33136" checksum="77E2234F3125B9E7" modified="2018-06-20" version="1">MAASDAEEPIQTYRDIAYLPTDGVYHRFDLYLPPGSTSARPLVCFVHGGAWRSEDKSQHEILARRIVSLTGYPVAISNYRLTTPSTQLKHPAHAKDALDFLHFILDWEGPPGSAQRPYDASRIFLCGHSCSAHMFTSIFLSPPNPDDSSAVLKPSQRLVASVRGVVLSEGIYDIDLLLRSFPGYREWFIAASFDDRLSYASFNTLNYEFRKGVEHIRWLVVHSKGDTLVDEVQSEGIYKRLHALLQDCKDGDGNAAIGSVERYWDLTSEHNVILKEKEYPELVSQFVLRDTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM67</accession>
    <name>A0A2R6QM67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM67"/>
    <dbReference type="STRING" id="98765.A0A2R6QM67"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS11003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="251" mass="26725" checksum="2717AAF0F433552E" modified="2018-06-20" version="1">MSSRSRNGDRAIGEEVSEELEKRICVVGSGAAGLITAHTLVRDGFRNVDVLSRDRSPGGVWAEERVYPGLSINNVHGEFRFSSLPMPPPTVTGAAAAGCRLSGEDMRAYMERFEARYLEGRIRYGVRVVNIRRRVGSVGQGSDDGDDTVAEARTGGRSQWIVSVQDKDTPGQLHEELRYDRIVLCSGGCHTACVPSLLSSEAARAKGFVGLVIHSSEVGQNVDALLSSVSPLSGLKPGTAVIVGGGKSAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXJ8</accession>
    <name>A0A2R6QXJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000299">
        <property type="protein sequence ID" value="PSS17118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXJ8"/>
    <dbReference type="STRING" id="98765.A0A2R6QXJ8"/>
    <dbReference type="OrthoDB" id="2796020at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS17118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="35062" checksum="266823B46CDB9710" modified="2018-06-20" version="1">MARPDASQWKLAEIAEIEAFIKAKLFVEVKKPDSRRLVDCKWVYMIKRGPNREILKYKARLVARGFTQIKGIDYNETFAPVSKFTSIRSLLALTAHHDLEIHQMDVKSAFLNGDLNKEIYMQCPPGFEAKDGKVWKLNKSLYGLKQASHEWYKRVCAEFKAMGFTRSDYDHAIFFKLEDGHLLIAAVYVDDMLLVSDHTPMIQKLKSDLSTQFKMTDLGEAHWILNMEIVRDRPRHTLTLTQRQYTETILNRFGLADCRPLSTPMVPNKKLEKLSEPEDGIDVKLYQSMLGSLSTDVCHDRNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXL7</accession>
    <name>A0A2R6QXL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000299">
        <property type="protein sequence ID" value="PSS17115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXL7"/>
    <dbReference type="STRING" id="98765.A0A2R6QXL7"/>
    <dbReference type="OrthoDB" id="2783063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS17115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="205" mass="22736" checksum="B25924A15599962C" modified="2018-06-20" version="1">MTTIYPVARSHQPSSRLYDVPSLENDGANFQTWKYRILMILEMRELMGYVDGTAVASGPSLPLQQSKYLQNDKEACAQITLTLKDEPLNGVLHTKMAKEAWDKLNTQYEGKGKQTIAFLIGDLFRGTLSDETALEPQLNTMRQKGYILSSLGKVLDNSLIAVAMVISLPPSYAVLCTILMSTDDKLTTDSVINAILTEEKSRQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0X4</accession>
    <name>A0A2R6R0X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000286">
        <property type="protein sequence ID" value="PSS18893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0X4"/>
    <dbReference type="STRING" id="98765.A0A2R6R0X4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS18893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="266" mass="30859" checksum="E09F6A8325B918BD" modified="2018-06-20" version="1">MNPHSEVSDTSEKRATLNTYLRTYWELLQSGRKGAGRQYVKTVVAQAWLNKFTTNSSDSTLKLRLCKWFEGKNRLKSRAGVPKAGRQTTHLRSPRRRSAREFFAKDIQQELKNATNDRMTLDHSPKAHRLKVRNTVLNEMWASLDEERQELHKRQSTTQHAAALRQRRETMTNITLEDNVRILDEELVPVVIRDFQRLLPGWSFDLKMGGPIGTNQQIVYRQYVVLDSHSLLRFIDHSLVATTCLQRGSLDITSLPIKRLQIPLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3Y8</accession>
    <name>A0A2R6R3Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">PHLCEN_2v3119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3Y8"/>
    <dbReference type="STRING" id="98765.A0A2R6R3Y8"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS19946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="210" mass="23099" checksum="45CA21A38EDCB38D" modified="2018-06-20" version="1">MSSELPPSKLGTKKHWDDVYSLELTNFEDIGDEGEIWFGEDSVEKMLDWTQENIPKEPAPSILEIGSGNGALLFALHEAGYNAQFICGADYSEDAVNLARAIGISRGEGAERVTFAACDFLQDYPRVTEGMSKPDDGETKVWDLVLDKGTFDAIALAEKDENGRTPADKYPSRIAGVVKPGGHFLIVSCNFTEGELKERFATQETGLHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R769</accession>
    <name>A0A2R6R769_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000272">
        <property type="protein sequence ID" value="PSS22621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R769"/>
    <dbReference type="STRING" id="98765.A0A2R6R769"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="11"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS22621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="211" mass="23222" checksum="99F432C40E033728" modified="2018-06-20" version="1">MASTAPANTPYNTLLLRRQLAELTKHPVDGFSAGAVDIPYTAPIVQTVIDSIIPNEKALSMTITCTNGSEGGFFKARLSFPEDFPLSPPKLRFITPMWHPNIYSDGNVCISILHPPGEDQYGFEESGERWLPVHTVESILLSVISLLSSDRPNTDSPANVDAAKEIRESFDSTTFALNLCPLACADLSSYTTAYKKKVRRLVRRSAEEAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6REQ4</accession>
    <name>A0A2R6REQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000262">
        <property type="protein sequence ID" value="PSS28491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6REQ4"/>
    <dbReference type="OrthoDB" id="2803471at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015329410" description="DUF6533 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS28491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="11045" checksum="BE65CE14F4A1E108" modified="2018-06-20" version="1">MLTDLIVFFTELALSVMSKASSNSSLIAYYEVIQANSYTDIAMLALAVYEYTITVGREIQLVWKRPKTGSVWLFLATRYLMILSFVPQIIPVASSGLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI43</accession>
    <name>A0A2R6RI43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI43"/>
    <dbReference type="STRING" id="98765.A0A2R6RI43"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40226" checksum="CF402CE5CA1E495E" modified="2018-06-20" version="1">MSLSRDVADDDSDACSLMSVSSGFAPSMASSATTADWDMRSASRPPSVLSMTSSLRQNAYRHEYGRGINNYSEVYRLPADEEELSRLDKQHIMFMEVMGKYAPPMEEVLADDTPGEIKTCVDLGCGSGSWILDVARDFPHCSAVAVDLVPMQVLNMPPNCRSEVDDINLGLQHFYGDFNVVHARLISSGIRDYAGLINHIALTVRPGGLVDLSEFDFQVYGTNKKPIPIDQHASAVARWMNLVHQAVARQGGEPDAANHIHGWLRDHDAFEDVHYRRWWFQTTTWNQGTDPESRRQNRYGAAMRDDILAFLHSGRPLLLGSGCPEHILNDVEDSARKELQEGRVPGFILMQHVYGRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIL1</accession>
    <name>A0A2R6RIL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000249">
        <property type="protein sequence ID" value="PSS29860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIL1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7674" checksum="026C6C30AD521EBA" modified="2018-06-20" version="1">MDCSVRDQAQKVQDARMGKRLEEYAGWSMCLQKGKLVVRNSGDRADYVSKQANSTCVIQERSSPTQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLY5</accession>
    <name>A0A2R6RLY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLY5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9449" checksum="173D5AD62BCF325C" modified="2018-06-20" version="1">MNFTVHILGGWSRRRASVTSKATPSRLHFLGGQVRELFDLDDSNSENSLNSESQEIEYKITALPAQRNKGITSIVSSVAAANSLVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM28</accession>
    <name>A0A2R6RM28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM28"/>
    <dbReference type="STRING" id="98765.A0A2R6RM28"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="671"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS31076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="938" mass="105268" checksum="C7C00150CECCD3B4" modified="2018-06-20" version="1">MHDVVTTGSKRKRVVSGSENALGNGRSSRAGSRVKRRRAMQDTSDEDVESSMEIDTRTPWELTDSEGDADGVDSSDSYLINSAEPRQLLRLRKDELVQLYQAAGLTEDAELLTKHEIVDCIMAARDDLASLPPSSPPIGDSGSSDYSSDGGNVAGGEETDLGHRFGNGLRRRNTVHDLGRGQRPPTERCYSLPQIQSIQRFPRLASQTLPKRRAVSRASSSRSSPAVSTTSTRPPSPPVTRTRSRKLSNDNSTTSTSSIRSKGKGKQVEFNDVIQINSLPEEPEQESDLTDLTELEESISQTNPSPRRLRSKGEREKIVSRNGVDKSAEDSEAARRIVPMRSAKRRVGSLKEEDTEEEDEEDELQESDAEETEEEDQLIETPTQTPKANKTRRTPLRRRLRPRRNQPQEPFSDGDDEGDDEGSDADATVEESDEGDEGGDERGDDAETVCEESEAEEVEDPSVLEPRVLRNGKVVGEDEDEDEDAIGEDDVDEEDMEQEFSEEGEMDDGDSQVQDDASIDLDAEAEVEGHDTDEHMEDDIDLTVATAKTLVRLRRDDLVRLCEYRDLEASGTKPQLAEALLQWRDKHCSEASSPSSTGTARPPSTTRPRRRKTRSSEKEDTSPVLLRSERVHLDEPRTPPLSERNKEMEPELELDLEMLGLDDREIPPEKLTKLEKIGSGGFKDVFIGRFKGRKVAIAEFRGQLNAMDIKELKLLGDFDHPNIVRFLGVSIPANTRETPVMIVSELCSNGDLFDYIRNVDPPTVYRALCIMLDIARGLEYLHTRKPSVIHRDCKSSNILITSKGVAKITDFGLAKVKQSTRSMMRSLVGTVNWQAPELWHAHPKYNHKVDVFSCGMVFWEILQWHVPNKKFPWEGMNEHAIYEAVGSKHQRPSVHGLRSRWCPEIVDLIEAMWAQESQARPAMSDVVRELEHLVQEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM54</accession>
    <name>A0A2R6RM54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000219">
        <property type="protein sequence ID" value="PSS31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM54"/>
    <dbReference type="OrthoDB" id="2791154at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS31111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="753" mass="86482" checksum="B370AD09B559B2F4" modified="2018-06-20" version="1">MEKAAWKELATSTARKFVGPMPARDFLDSFLPRTPGMARVPTLKLPKTFGNDTHRNLERAKDVLFSAIRTCRICPNYKFLAAPPHKRHGDWYYHSQVAFLYPKYFRVRSCADSWQSAQMFVAFVVEHVDPFDSTEREWRDDDDTPYARGRQISYAKSQIYHQHRAFTFSLSILGRRARFVRWDVAGAVFSESFDYVSQPTWLAQFFWRYNHLSSAQRGLDPHVEPATLAQSRMLTQAMKVYLGKVKIGVLPLIPMVEDTLDKRHPTYKIHFDLTDKTPPFDLIVRRPFYNKPIIEDSGTRCYIGYHLGLRRLVFLKDFWPPHTPKQGIIEPDMYHFLASLKVTHLPDVLYADTPFWRSSNANPSFSLTQDLAGKFQGCNASKHLYARIHARIVQDIAYPLKSARYSRQLVQAIRDALIAIAEAYSNGKVFHGDISSNNIMLTAFGRGILNDWDRGLLETDDQWETFGTWSYLSCGKLRDHRKQHDIKDDVEACFWVLLHQALRFFMPRNKHWDTAMFHEQTEYHDAAGRRVKSGGGQKLMFLLRCHDPGQKIPIPCAPLRDLVHDFRDVLSRFYLATRVLGHSPEDQQVLDTLQDPRAIAKLFDKALNRPDWPTEPDVVLDQYGAMRKHQSFTAITEFTDGLNVRPLSTIHDILTAVPAEQGSFCLWGDFIPQRTGSALNQDSSTSHTRSSTWTPSAAQSAEAQKTLSVSQPLILRIPAMKDRPLGGTKRRREDVTEDADVEGSPGRKRVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPH6</accession>
    <name>A0A2R6RPH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome maturation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000213">
        <property type="protein sequence ID" value="PSS31938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPH6"/>
    <dbReference type="STRING" id="98765.A0A2R6RPH6"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS31938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36369" checksum="7A789D0D1B63AF59" modified="2018-06-20" version="1">MDLGIEYKPLLTDPSLDFSDRLDTRRDEGVNATKDRLQQRIRILSSICIAQSLLLLVAAVALVLGRKSNDVVDLSHAQLLYSPAQEALTFEAKKYVADIEDITIYRGEPSNAVDNDWSDLYNGKFWGLSSAYQPEDCPDVQPTLAFGVSRISKSEARLLPNQTLAIPGDENHHIISLSVFHELHCLDPSLRLVPSGPSKVASIQDTANSFGLHDTLTYGPRSLAAEVKKSSSVKDRLENWEATQDNLKLNLQRNAYGLHAPVRMLMERQIVGHNPHMPAFRTSNIHLDILMGRDETLECADFMMPASELSQPLDIHAEMERKLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVL8</accession>
    <name>A0A2R6RVL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000158">
        <property type="protein sequence ID" value="PSS34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVL8"/>
    <dbReference type="STRING" id="98765.A0A2R6RVL8"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="496" mass="52219" checksum="366F5913CB3DB21F" modified="2018-06-20" version="1">MDRLESLGTTLSQITMYDIKNMYNQAKNVVLNVSEMEAKVREATNDEPWGASSTLMQEIAQGERVVDDARSHISTIKMLRNFYYIDEKGKDQGLNGESQYLDLDLQLILRISVRNRSKELVELLSDVEKIRGERRKAKVNKNKYTGTGNDALSFGSGGGRYGGFGSDSLGYGGGSGSSFGAGSGGSYGGDREYGDYSGGSGGFRDSSSRKNYEEYDAGDDDVVTARRSNSITVRGSTSSPAARRSSTTPAAPSAPAKAKAPEPVPNLLDFDDDEFSAPAPNPSANKALPTAATTHADADDEFDDFIAAPPSAGVSTPQPAAPPRYMSPPVTQQQTSFTPQQPMGLFNMLSSPTTSSPPPIGMATNRQPSYMTPTIVPSNPMFPSQPSFTPLAPASRTGSMLGSTAQTKPTAKPASSGGNFDDLWTMSLGSSSTVNKSQNGVTGPAKSMKDLEKEKAQAGIWSTGQQARPPMGGAFGGAATAAPPASSGNGLDDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVY0</accession>
    <name>A0A2R6RVY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000144">
        <property type="protein sequence ID" value="PSS34187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVY0"/>
    <dbReference type="STRING" id="98765.A0A2R6RVY0"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="3">
        <location>
            <begin position="120"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS34187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54252" checksum="733C865B5AD6893D" modified="2018-06-20" version="1">MGLQGLWKLIEPAVDCSQSMTELAVTKGFNAHPNLGVYRIGIDASIWIEQIQQNFTGQGHAQAGKNIELQTLFYKLARLLTVCVQPIFVFDGPNRPSVKRGKKVFPAPHWMVGDFKEFAEAFGFHCHTAPGEAEAELALMNELGFIDAVLTEDSDAFVFGARTVIRNISYVNNEARLKVYTAEALQTKLNVALTPTNLVLIAVLSGGDYDNVGLPGCGLTTACGLARYGLGDTLRRGVLGFEGDNYRDYMHEWRADLCHYLRDDPSGFIGRHNVHLSRNVPDDFPDPEIARTYFAPLTSRYAPLVPLPMPRFPDVSAITRLCEMEFTFGTELGILCKFRNVLWPGLLVRELLEQAFAQENGLRELPPSGLFDIEIKSIKEGTTKVKVHPRAIKYVVRKALAQVRNGKDKFKGATGVNEAKSQTPRVFPVPTEILWRARPTDVAAFSNTSPHKRRHISTEIASTSPCNIAVAKACTRVGSLPAAIIDLTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZK7</accession>
    <name>A0A2R6RZK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v1619</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZK7"/>
    <dbReference type="STRING" id="98765.A0A2R6RZK7"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSS35464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="152" mass="16531" checksum="B5FD6CCAFE3AAF10" modified="2018-06-20" version="1">MASKIITYDELKANSTKDSLYILLHEKGPLSFSQWECAGLLMSRPTVYNVTKFLDEHPGGDEVILAEAGKDATEAFEDVGHSDEARALLPDMLVGEFEKGGELKVKTAGKTSVSQSAAVNTAVQQGSNLMYFVPLGLLGAYFAWRYYSNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S020</accession>
    <name>A0A2R6S020_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000111">
        <property type="protein sequence ID" value="PSS35614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S020"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="13516" checksum="02DFA11F9C376BFD" modified="2018-06-20" version="1">MEVLHSEGITYDPRDPNAWAPHGEHGRLASTAKRAWEHLCLVQEEVDSFDRMLEDSAARQRRDAEKQLLAVLEASGLHNQFMHTARNLANRWRIVGLARTVTYGVRWIRRTLRQTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3E1</accession>
    <name>A0A2R6S3E1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3E1"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="426" mass="47301" checksum="AEC9FA45FA6BE411" modified="2018-06-20" version="1">MLDAQDEIERKVLVEAEPRDPTITISSPRAKPSPANKLKRSTKTRSVPSTPSKPKSKRACRSPSPSQPSITSFFPLSPSKVATDEEMQESGETNMRPVTPVSDLPESRRTYPPLPRFKLHLSDTKTRSHATLPREEDTLPARLQLMLYHRLLANLLETPSCSQALDFDELWIRLGVSPSLPFSATFREQTGLPMQGPRRDRVGCLSDLVRMWRNAVEMIYVEDLGPALTVVYRTQPRKSRKGKDKGKGKAKSASRHQEDQDIAETVAPTKDQEPGIDNEYQGPSHAGAENTDSAEHNPIIVDPGGSSNGIDTNDAAPSNFGDIFTPSVPEEDVDLQWAIQQSLLEQIQANPELNETLVSAESAEQQQQDTDDEDAGCASEQSTVIGTKTFQLDDVLLDDYLTNVLDWWHGRRAPRGVDIELTKRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3L5</accession>
    <name>A0A2R6S3L5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v1273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3L5"/>
    <dbReference type="STRING" id="98765.A0A2R6S3L5"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS36845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="171" mass="18807" checksum="CDB0AA4BF9C1CEB9" modified="2018-06-20" version="1">MASKAAVAAVVSESNHDPKSTQTVAALQAFRKRHGDAQQAHAQLEAQPKTVDLSYYRSILKNKAVVDDAEKLLKDFKPVSYDVSEHLKAIETFEAKAVAKAKETADKIDVELKDLQATLANIEDARPFEDLTADDVGAAHPRITEAVENMLKKGKWTVPGYKEKFGELSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3P5</accession>
    <name>A0A2R6S3P5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000097">
        <property type="protein sequence ID" value="PSS36839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3P5"/>
    <dbReference type="STRING" id="98765.A0A2R6S3P5"/>
    <dbReference type="OrthoDB" id="3246048at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="488" mass="56348" checksum="E26664797FD2D6B5" modified="2018-06-20" version="1" fragment="single">GPPISEEAAYWVVSRATRVWRVREMHFHESSNEHEYTLGEPMALKDAYLFEDAVLESGIKEQIMASLKDAGADDKDAARYFMEYEIDEVALLPNENETELEDDLTSDMETNRPASYTPGNEVPPVSTLPGSQRTSTSRRDAGHPDPSDSTKATQRTNRSATQETLPRRYRRKHVRTIFKHVCQSMYELTDWETFVQCMRHLIKGLGYMRRAGWVHRDISGGNCLWDPASRQGKLADLEYARPYKHESLLPHEARTGTPAFMAVEYQMRKYLYSVTAHRDNIYDLSPKGESVQRLTFTYNFYHDLESLIWLYAWAVYFRPPLLRVPPSSGTEELLRREGHRFFACGIEGNIERWDAVKDGPRGNHLLTVVIDDTVYGVKSGCRFLIGGMETIRHLAQRYYDIQSFPTNDSLRNGTAIWSADHFTYDVYKKFDESLEKVADLIKKVGDTFPMRHISSRREKTKRRRTEDPDSPTHHSGKGNKRVKRSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S401</accession>
    <name>A0A2R6S401_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S401"/>
    <dbReference type="STRING" id="98765.A0A2R6S401"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45848" checksum="B31DD2E896E192A9" modified="2018-06-20" version="1">MTFAKITIPIVVLSIFFTFALWDPHIEVTFYSREWVKQEVKTLRPLSGCFSPERVSPKYNLTDALYGKKKTTVHAGMPLRLGMDCYDFAGTIPPTSMDDVSPAYIHPEDRVQYHTYWRTDLAPFGERQEWMLKSFFATQSVNSSRLVLWSNGDLSGNTILQEYLRSYPDAFLLRKVDFLSLAVGTALNDRDLLRVQDQKAWVDGDLLRLLVLWAYGGVWVDMDTLLTRDVEPLLENEFVTQWDCYDKLYVPFNGALMHFRQHSPYLCEAFHIMNTSAPPRAGSTDWGATLYLKLWRRLVVSSIPPFSVLPFCFSDGRSCRLDNRLPDPFEPDPPSGIWTEGMRREEGGGLDNVLGKVFGVHLHNQWAKTFPKGGWVDRLLLRRYEKRLGSLDGQQARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S403</accession>
    <name>A0A2R6S403_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S403"/>
    <dbReference type="OrthoDB" id="2734547at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41371" checksum="5F0E5CCA6DE08F7D" modified="2018-06-20" version="1">MIPSLPHELSDRIVDFLHDDCLALSSCSLTSRSWLPAARYHRFSSVTLVGNIEPFNVLLDYSPDIALFVSTLILANGYVLSRRLTPQCLSSLLDRLPAVRRLDLLGLTLKPENVEIIAKQLSLVSFSAMGCSFYTSGSIQHLLSSLPRLERLTVEDLLWQDDGGLIDNMPRPNLRAFRVAGLDYPAIDQLCTWLLQDGMDSNIRELRACIRGKHDAITTQAMLVKLGGSLTALDLVVDAESNLTACLSNLRSCHLGVNLREMCVPDNHSLPWISRLVGTLSSKYLESATITIKADNMQDLRSLDSECGVRVPALVSFDDLTSLDWVALGNVLNRGKLPALRQVVLEGVGRKDRLESYLGLGYPDLHDLIDFVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4G0</accession>
    <name>A0A2R6S4G0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4G0"/>
    <dbReference type="STRING" id="98765.A0A2R6S4G0"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="42"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58223" checksum="A065BB2B2702F61C" modified="2018-06-20" version="1">MERIPIPKKMEIHLTDSENEICTLLDGCTKWMKEEKGVETSCRIAGGWVRDKASIQLLGSDSNDIDVALTDMMGLPFAEQFQQYCNDVKGLPVEKVAKIEKNPARSKHLETAKTTVLGVELDFVNLRSEEYAEDSRIPTQVEFGTPLQDAIRRDITINALFYNVHSRSVEDHTEKGLEDLINGTIRTPLPPRETFMDDPLRVIRCIRFASRFGFSFVEELQTAARDPEIQLALRTKISRERVGEELDKMMKGRDPLRAIQLIDELSLYTSIFHVPDDAAPAFSAPIASPHVGLAAASILHILTNPSSVPDLCLPSLHPLLSSSVVHDQTTLRRLYLAAALTPYRSVTYTHKNRIHLAVEAAIRDGVKLGIQNHYLDGIPALFQAADLLETPRIGGERERQTMAEEASKRIGLYNRFMSRAEELALPDTVDAKPILDGREVVRILGASKPGPWTGHVLSRVVEWQLDQPAGTKTQCEEWLKAEHVAGRVNFEVTPAFQVKRGRRDSQGSNMKKVKTDDSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4I6</accession>
    <name>A0A2R6S4I6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000077">
        <property type="protein sequence ID" value="PSS37204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4I6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="177" mass="18179" checksum="3B9028689543DB0E" modified="2018-06-20" version="1">MEGMEGMEGGTLEAGGGRCDMKSGESRRNAMSARRDISGVSKSSPEVGVSGDEGVEGDGSGWSSSRVGMVGSGDETRGSFEDKSKGFSGSFSIKVGSLGGGGGRDVDDLVRRLVPRVRSMGSGASPKALRRDRVAGRLGLGSTMAGLEFRCIEGYGWKGKECRSDSVSSAPLAVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4J3</accession>
    <name>A0A2R6S4J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000079">
        <property type="protein sequence ID" value="PSS37201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4J3"/>
    <dbReference type="STRING" id="98765.A0A2R6S4J3"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="179" mass="19601" checksum="59BA7C6776409078" modified="2018-06-20" version="1">MPQFSPLVPFSNEPKSARKPIRVTQTRGKSRAFLVGKSDGISSGDPFFCVSDSEDDLEGRSTAAVPKTPSRRHKTQPRATRPSRSPSVSSDISTAVVATPTKASVKRGTKTPRMTKKALQAAEFERRAKYAQELFNELNIAIFDGGLPTSTSLKWSNRLLSTAGRAHYRKSVVPRPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Z5</accession>
    <name>A0A2R6S4Z5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Z5"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="364" mass="38176" checksum="B81E3D5E69A2CC19" modified="2018-06-20" version="1">MDSVVSKLSEAKNIRIELQDSGCVLHADIKLADGTFKPAEYPLDMVLGNLNGHFTWGFKGFSKSARNVSINGTVLTAELRAEDESWKSDSFDLNGRIVIGGQELFATGVPCVLAVPKEAEAAALQSLSDTLDRRPELGLVGMKQPDGSYMWTLKPNVIDTEAMAVAGVALATSGAAAAADSEFDFDHRAEVSTGSNPNGTTGGHVVIGVGIKGESYLDDGAIFFTAEGEATASAIHVAKTKGRPIEQVEVDILEAGASASAEAFGTKYFPIPLLKYAGAEAHVNLLKAKASVFDLSLGLGVDTDAGVKDGSVGLHLAGCGITVGRKLSISAFGTGIGIDFGRFFWLNGFLSSAVFLWKLFDGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S535</accession>
    <name>A0A2R6S535_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000055">
        <property type="protein sequence ID" value="PSS37372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S535"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38845" checksum="48E45F99887018B8" modified="2018-06-20" version="1">MVLALKELTSLSLPPYNLGISLIAALSTHQTLRNIIAIGRNSTRGALRWDDSHAIVTQPVTRLDGSSARLVGLAVTVPIHTFLSFFSNQFDLNNITSLHIIISEEVGASDTLRAAFSLIVDRCPYLENLTVSLAQSYDNPWRISYDVLEPLRRCKRLVSLDISSTFTTNINEEEFEKLVSNWPKLQHLALDDAVPVSPEDQVSLSLGAVMNLLHKYCPLIFEYMLPVSMTLQPKWFTDPGFCGRMNNLRAVTLLVDSPTATDTPQIAMYLKWVFPGHCKLNYHPAFHQTAPELHLREWEARRSALLAFTEQLMQAVEKLSSGGARESYHTDLLWIIDLNLSTAQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S560</accession>
    <name>A0A2R6S560_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S560"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="10113" checksum="C1506B2B5FAB7EBA" modified="2018-06-20" version="1">MIGFLVAVGFDYAAVRFIRVSDSYIVHLQIGAVDSSIGNIVAFIRHARNKSDEASKAEHMEMKSRFKSLLNLGYTLSFDIVFGALMYPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDR8</accession>
    <name>A0A2R6NDR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v13654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDR8"/>
    <dbReference type="STRING" id="98765.A0A2R6NDR8"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR70503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="34639" checksum="E0ABEA27C079484F" modified="2018-06-20" version="1">MRPNFALLSDRYIHGTEPTSHYLALDPSFKNPADTAETNGLRVTIDSTAMWNSQMERTELIPQTTANLGTGNLFYHFSIMTTSTNPPNPAYEHQILFFESHFTELKFGVGPTTTDIQWMVSSNFQWGTPFTPGTWFNFAYDIDFSAQTVGLWASTGSAPLTKVAQNVAASTSTNSEDFHVGVLRLVSGPDTEDWYISGVYIESGPITTSVGNGTGSSVPPSSSSSASTVTPSVPVSSSSVPPATSTSAAPGPLQSEYGQCGGTGYTGPTTCASPFTCKAISAPYYYQRHSCTNIMTGTHGRDLSESGTRWTPLQVQALRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE60</accession>
    <name>A0A2R6NE60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001337">
        <property type="protein sequence ID" value="PSR70667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE60"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5461" checksum="3ECD402013E211C7" modified="2018-06-20" version="1">MGEGLLEPKQGPSSDEVPGKPASPPPVCPRRNEERIITVHRLLNLWSNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEA2</accession>
    <name>A0A2R6NEA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v13434</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEA2"/>
    <dbReference type="STRING" id="98765.A0A2R6NEA2"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="292"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="188"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="504"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="701"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="588"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="752"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR70704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="886" mass="95540" checksum="0C9B8642D795AE1E" modified="2018-06-20" version="1">MFRGGQPNPYDEIVAKTTDENLTSENWELILNLCDKVQDEGESGARNVIAAILKRLTHRTSNVQLYTLTLAESLTKNCGIEVHREIASRAFTQGLERLVLDRNTHDKVRRRVLGLVAEWTDDFSKDPTLGLIEECHENLKSKGYKFDAPNEPPPPDVDDEIRRKEEEELQRVLEMSVMDKGGRGQWGEYSLASSSGTGTSASGAAAAAAGSSSRPEAASTPTAASPATRQPQSQQPIYGGYVPSSNPTVSTSQANTTVHTPVPPVSAAPYSGGAGVTTSPVPSMKSQDSGIPIVTRVRALHTFEPTEAGELAFEKGEIIKVVDRGYKDWWRGQLKGRTGIFPVNYVEPLPEPTAAELAKEAEQEAAVFSQAANVDRLLTMLRQMDPAKDNLADDEDIQELYRSCMSLRPKIVKLIDKYSQKRADLVSMNETFVKARTIFDRMMEDSLARHSSTYDPRAAYAQPYPRPDSGARVDYPPPQAFGWNPSVYDQPGYAAYPAPPAAYAPGPEPPFHGGPQPYPEDAPYPPQGGYPPQPYGAPPPGAPTPYAAPPQAQGYPVGQPPQQQHVPQASRMDSAQVQVQPATHPMHQAPVQQHQQPQQYVQQPQGQPQPAQYVQQQPQGQLQPQSQLQPQPQSQSQPQSQPQPQSQSQPQQSHQPTPQLQTGPPYVYDPNMTYPDPNVQAWAQYYAQGGTDPTGALYFISVPGVKEDNTPPAQGASPENPSQVTPQQHPVDAQPQGYQAHNGTLGPAGQEPFSTVTSSLNVHHTNAHPQPSGIQTVAPGSPTTPHSQAPQSFYQSSAPPQATAGEINATSGNLTTVPAQSVPYGASPYPPQEGYASPPTSPTRVAGAAHQGWPAQYNNLPNQFASMDVGGGQGVNPGQQGVGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF98</accession>
    <name>A0A2R6NF98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v13024</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF98"/>
    <dbReference type="STRING" id="98765.A0A2R6NF98"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR71055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="9850" checksum="48BDD38425937303" modified="2018-06-20" version="1">MSTETGKKTRPLNTAEGFVLGGLAACVAVTFSNIPDVAKTRMQLQGELAKDGGVRVYKNVVDVLAKTWKNEGLRGLQRGLGPAVRYFTGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFN2</accession>
    <name>A0A2R6NFN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v13002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFN2"/>
    <dbReference type="STRING" id="98765.A0A2R6NFN2"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR71156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="254" mass="28132" checksum="41F6B6E37FA1ACFC" modified="2018-06-20" version="1">MASAQDKCPVDHNALSSSKDKCPVDHGAHGASSEACPVDHNTRTSWTNIFSKKSTTPSPSPALAGSSSSSSKLPTERETSSIPRVDGNNWVYPSQAQFFAAMERKNHNPHAPDMKVIVPIHNAVNERAWAEVMKWETGQGGEKCGGLKLVSFKGRPSERSLRARWRTLLGYSPPFDRHDWVVDRCGTRMRYIIDFYTGHSAGPSASNVSFYLDVRPAFDNWEGVKLRAERFLDRWVGSFWNTTPTPPAPAKTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFP1</accession>
    <name>A0A2R6NFP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFP1"/>
    <dbReference type="STRING" id="98765.A0A2R6NFP1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045912">
        <property type="entry name" value="FOXJ2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078:SF2">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46078">
        <property type="entry name" value="FORKHEAD BOX PROTEIN J2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="303" mass="34242" checksum="3CC90175B842AEC6" modified="2018-06-20" version="1">MEKKYPYYKTAGPAWKQSVRHHLSLNRLFERQPRPATDPGFGSYWTVNLEAPPGTKRPRKRGRAQKEAQAQSTTVVDKSPYNRPPPPPPRTDLPHSGHPPIATLRPVDAHSFRTSAVRVSPYDDDEDDEEEMPWEGGAPIVMSDDDYDSEERSPYHYNPPMSASSSNTAGSFHQAQGPPRQPARSGSNGTSYPSPYGHSPTSDPAIERLKQEIEGLKRQTTDQEHLTLRLSNQLTRAEAEIIRAKHSLKMAESRLEDEIRRRVEAERAADEEAKMRRSAEDNFRMLQLQTQRITGHSSSVMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG40</accession>
    <name>A0A2R6NG40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001288">
        <property type="protein sequence ID" value="PSR71344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG40"/>
    <dbReference type="STRING" id="98765.A0A2R6NG40"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015321659" evidence="1">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="13869" checksum="AAE5BB3926829449" modified="2018-06-20" version="1">MFISRKLIPLAILPALVLGQEGIGFPHDYPGKPTGDFSPEWQAYFQVTDPLPNVTFTMDRNWAGNIPVDRPGHPNNTLFFWGFEKENGSLTAGDGERSNEPWGIWLNGGWDHLADYIWVDQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG91</accession>
    <name>A0A2R6NG91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001286">
        <property type="protein sequence ID" value="PSR71376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG91"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6023" checksum="B39AB5647A1FEA66" modified="2018-06-20" version="1">MDTHAVGLGAAHGRASIAPAVAAVGTGLEGRRGESEERESEEDSDGELHVEEYKECGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGP3</accession>
    <name>A0A2R6NGP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001281">
        <property type="protein sequence ID" value="PSR71489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGP3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="480" mass="51941" checksum="94535D0AAEFEC2C4" modified="2018-06-20" version="1">MPSSPSTSNASPASSRFNNHHFKLTPLEAAGLEVLQADFTVLQENRTANELFAEQTETKEDLLVGLDVSPELAATLPNWPKFSHLLRALCESGTDQQKPPSRKQCPACKSLVVGVICKRLGKASLHMHHPGPCPVQLAAIHEVRKRDMELLVKKMKSCAERAVTDNQSEAGDSPGKSKSKRKGKGKGRASTQATPVKLETPATPSLFDGPLTPLSQLSATPMKLQSPVKEETPVKLMNKRGAQRTPKTPKSVGVPQVVDDMFTSNTVGSNSAGGLFPVLGKRKWEQAGEGEASPSTSSSSSLPSVGEIIRASKVRFCDDMLHYVFDRQTQRTASSPTSPTPVRHKVQHAEGSIVRQPMPKEVLIAPGDEVLTVAAKKQTVANEPIEVEDDDLLRDDNTIARFWCNKRVFIDKTPISVNSDSDSDSELGQAGKTTEAPVAAKREEVEASFSSDDGATVISSHPEAFVDLRVVVWIEVGIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH48</accession>
    <name>A0A2R6NH48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH48"/>
    <dbReference type="STRING" id="98765.A0A2R6NH48"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="177"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="119"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR71312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="372" mass="41208" checksum="DB3454CB4D46E03E" modified="2018-06-20" version="1">MVLAPPADGFSDVISYISQLALDDIESLQERSRNKGRDEEIMTDEELAMMIFAEEAEGLLNIRREHISERSNKPRSMLQELLEMEEAARYDHQVALAISEDRPIPPRPPRIATLTDTFQESDYESDSDSSSLVGSSSQKASSSGSRAGSILDDDSDEDEDDFFRYPASSKAPEAEPTHANCTVCGDDLAGMSVEAPCGHFFDISCLETMFRKATIDESLYPPKCCMVSIPVASVRPLLDSKVMSAFEKKSIEFDTPSRVYCFKSRCSAFLGATTEEPSELTCSDCSEKTCGSCKAEAHPGVHCSDTEDLNSLANDLQTKQGWQRCHSCHHMVEKSEGCYHITCICKAQFCYLCAAPWKECGCPQFEVPPELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHZ5</accession>
    <name>A0A2R6NHZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001233">
        <property type="protein sequence ID" value="PSR71911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHZ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8500" checksum="89D44FB2C4CEB7E3" modified="2018-06-20" version="1">MVSRHPSLVKSYQRTFSFITFLKPLASSIFTSESGGKMAADTRAGARASVNAKRCGKSIMVAFESQVESEEHRNEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI97</accession>
    <name>A0A2R6NI97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001222">
        <property type="protein sequence ID" value="PSR72080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI97"/>
    <dbReference type="STRING" id="98765.A0A2R6NI97"/>
    <dbReference type="OrthoDB" id="3269712at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8356" checksum="FDBDEFB293EA946B" modified="2018-06-20" version="1">MATEDLSEWKEGSDKVVEQSAGPGEDVKVDVQKNAYGPEQTTTHPLHEAEEAARDIVHRIRQKLSPENTEGKGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIW5</accession>
    <name>A0A2R6NIW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIW5"/>
    <dbReference type="STRING" id="98765.A0A2R6NIW5"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="12840" checksum="F655D9786461CD78" modified="2018-06-20" version="1">MSYFYDRLNPLLPEFNAAPPIKVSTLATYAEQLCQGKPSWKTQWGHDDVLMEEIEGRPEWCLDMTFMHALLRLGYEFGSDRPVEIGKRIDGTELGWALGATISMVSGGELKCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIY1</accession>
    <name>A0A2R6NIY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001196">
        <property type="protein sequence ID" value="PSR72326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIY1"/>
    <dbReference type="OrthoDB" id="3226552at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="425" mass="46689" checksum="498B401342C43FC9" modified="2018-06-20" version="1">MSYPNYQMEDRSHRWSELVPPHTALTFAAIWDPDEGMVTFSGGKLLDSDLADSSTLRDTPRDAYDGQSQVLTIDRFTAPFASTVLLSGGEEGRRTGATVRFARAALDDAQSVVDPYFRGVFRRQQLSQDEMSDDNISLDPINISRGYRTMGHKRQGAVIDWSHLRAVGRHIYSAAVAPFDGRRSSSSDSSVTDEGFFEEVPWTAGTLASAPVMINLNLKSAFSVTTTSTTGYVDVDVPSGPPSGNRRHGDGSVLHSAPSEAWSTLMSLDKGSCPNGPPERGRRLKKPRRGALASVYTPADPVEVLARKEYNHITTYPEPSVMASSPSCYSQESEPFSCPNPGSGVNRLKSMPRIDRKTSQESSTSATLDGNTSSSATLRRQKSMVKVVKERVDRLTKCRKVEDDEKWVCVNVSHRVTQRVCVIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL91</accession>
    <name>A0A2R6NL91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="16">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v11025</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="16"/>
    <dbReference type="EMBL" id="MLYV02001105">
        <property type="protein sequence ID" value="PSR73123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL91"/>
    <dbReference type="STRING" id="98765.A0A2R6NL91"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000119">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR73123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="276" mass="31061" checksum="34DF986814675985" modified="2018-06-20" version="1">MASQQSIQYSVVVPAYRENGNIRPLVTRIFAALRRIDSPVPAEQTEIIIVDDNSRDGSVENVQSLQQEGYNVRIVVRTTERGLSSAVVRGFQESRGDNMLCMDADLQHPPEYVPTMLASLSPTHTFVLGTRYGKGVEMDKDWPMYRRIISSGARLLALPLTTASDPMSGFFGIRKESFLKAKTLNSQGFKIALDLLIKSHIPPYAIAEVPFSFGVRSEGESKLTGKVMIKYLEQLAELYWYKFSALVVFIIFFLFIAFFLLLRTWFGSLSPDAQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLB8</accession>
    <name>A0A2R6NLB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001105">
        <property type="protein sequence ID" value="PSR73126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLB8"/>
    <dbReference type="STRING" id="98765.A0A2R6NLB8"/>
    <dbReference type="OrthoDB" id="2803765at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="23517" checksum="BBA66FF24538544E" modified="2018-06-20" version="1">MPRKAAAPAADAAAEPRRSSRIKDQPKSETLPKKAPAKPRAKKTKAETSAGEEESKEPEAAAEKPKSTKGKKRTAAEKDAEEETPAEGANGAAEATEEPPAKKATSKPSSKAAAPSKPPSKAATKPASKAAAGSKPPSRAASTKPASKASVKPPSTTAKKPASRAGSKKPASKGFRRIAETGFPESDSSIFQAEATKENGTDAAPAPETIAEDPEAEAEAEAAEEETAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLF2</accession>
    <name>A0A2R6NLF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLF2"/>
    <dbReference type="STRING" id="98765.A0A2R6NLF2"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9015" checksum="DABDBC99D0EB8190" modified="2018-06-20" version="1">MTLAVDLLNPIPASEARKHKLKRLVQSPNSYFMDVKCPGCFAITTVFSHAQTVVLCGACTSVLCQPTGGKARLTEGSSYRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLZ8</accession>
    <name>A0A2R6NLZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLZ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NLZ8"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="590" mass="64394" checksum="DA8D60C6440353AA" modified="2018-06-20" version="1">MSSFSLPTINDNPDGGWGPSSSNLPSQFKFKDIPYAPYSKSDKLGRFADWNDISGDNRQPNLGLSSAQNTRGGGPGGRGRRDGQPAFGSGTASAFAYFHAEDESSFSLVDTKVTTTRRGGAMTRGRGAGRGGGGFANRGGAQRGGRGGFVQRGGGAQRGGRRGWRDWEKSNRTREASVAISPEWSMLEEIEFHRLAKLRLEVDDPDDLETYGRLFAYDKSYDRITTKTEKPLQLVDRMKYNITTSDDPVIQELAAKDTATVYTTDVILSGLMCAPRSVYPWDIVIVREGNKLFFDKRDGGPFDTVTVNENAADPPQDPTPANPNNPNEKSAVPETPSMNTATSLSLEATYINQNFGFQAVLETPPPPPVDLSKPNQFYGPEETEPLASCGYRYRVFDLGVTEDEDLKICVRTEVDAYSSGQGDPRLGQGLVTIRALNEFDSRATGAGGAPDWRTKLDSQRGAVVATEMKNNSCKLAKWTVQSLLAGADLMKIGYISRANPRDKTRHVILSTTSIRPADFATQLNVSLANGWGIVRTVTDLLMKQPEGKYVLVKDPNKPVIRLYAVPFTAFTAEEEEEDMGFDGEDPESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN17</accession>
    <name>A0A2R6NN17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN17"/>
    <dbReference type="STRING" id="98765.A0A2R6NN17"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="14064" checksum="C708C236FAB005E7" modified="2018-06-20" version="1">MLATPTISVPFDPTGRSDTPLNSLVQELSVPARFPHTRAQLTAIARQHRPLDNYDDDNDDESNRITSTLVARVASLLDSEREDELKVLLKDSFGPSIDDDEVLPLHSMHPRHLTDLIPDSFLNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNG7</accession>
    <name>A0A2R6NNG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001048">
        <property type="protein sequence ID" value="PSR73932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNG7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="16356" checksum="1E7AE1EB839ABAB1" modified="2018-06-20" version="1">MATRSALPGHETIPANSKCEDRVNPAVLADSEDICAFFEEEKTEISTTHMQDIGNPFTDVYMDTGGDNEGGYIDNEGNQVFFSAGEDLSSPTLVELARQLDAMGRGEDIALNIPFREPLAKEAEIDEILGGDPTLTGIVQALRDMGNIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNH6</accession>
    <name>A0A2R6NNH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNH6"/>
    <dbReference type="STRING" id="98765.A0A2R6NNH6"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10430" checksum="07B583AD88B96E8D" modified="2018-06-20" version="1">MAKRKAAQKPPSPESKAPLVDISEQDQWKIINDSGILHKIQDGSGVQESAAETTDKEEPLLSPLTEEIFRALSLIIPHASLLILFEMYVFVCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP24</accession>
    <name>A0A2R6NP24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001014">
        <property type="protein sequence ID" value="PSR74188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP24"/>
    <dbReference type="STRING" id="98765.A0A2R6NP24"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015325483" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="176"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="339" mass="35747" checksum="09D487B5DFF0E74E" modified="2018-06-20" version="1" fragment="single">MLISLLALFTLAPLALAQNETFLAGFVATLQSAGLTQLISIAGTLNGTANGQALLANISNGSPHLLFAPNDAAWAMAPSNETSDNNTLLDTFSYHIVPGNFSNVDTMYQNVTLGQTLYSDPATVHLEGNRPQVVAWTVRSDGKTHVLNQRNDSTVVNTTAFGNITIYIVDHVLHVPENLAAAATANDALPAFDTVLSSASLAFYNSSTNQTSDVTFFDAFDSGYRGFTLFAPNTAAVNASNSTLQSLVSNRTAINNILYNHLINGTTVYSPLLAGSEKYTSAAGQTLSFSINATGQYVTLGNITATIVQPDILLPNGVIHIIDQVLLDTDNDPSAASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP38</accession>
    <name>A0A2R6NP38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001010">
        <property type="protein sequence ID" value="PSR74220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP38"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8461" checksum="D1641759EE41CD6B" modified="2018-06-20" version="1" fragment="single">MATMIPGGSNTHKTTAAEEERIKLDKAVRNIISDIANDKSRSNTQGWPEMARTLRDVDEEKIKDTKEDIDTLLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPP2</accession>
    <name>A0A2R6NPP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001021">
        <property type="protein sequence ID" value="PSR74082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPP2"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="14"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="779" mass="87863" checksum="395A18EF7455590B" modified="2018-06-20" version="1">MLIQTNAPIQHTGWTSLEKTIHDLDEAKMKDCKDDIDTLLIFAGLFSAVITAFLVESYRNLQRDNKVVMVDLLRQISAQTRGYTTTTGFINATATVAVSDPSLPFEASHDDIRVNVLWFSSLIFDLSAASFGMLVKQWLREYMAGDHTSPRVRLRIRQYRNPSLARWKVFQIAAILPLMLQLALGLFFVGLCFFTWSVNRHVAYTSIPLVGVWALLFLSATVAPALSPRCPYKTAFTRRGMKTLRKLLFRIAPGRVLSSLSSMLHWKTVKPLSSRPSNEKDLEESTSGNCDVTSVMFEEEDAIQDDGDDISLLTTLDEMLLDDNLLFTSITQALRQMQADPFDTIKFIFGAVGRRIHEDFPLETTSLPNLQRKLTKSVWHNSVDITAEVIKTHLDQPGRDSHWPDWMSHALTFLFSLCEHTLTEEAEHAILMCLSSRTDPVIRNGAIRIIASHAGDKVRYGHILRQLRGVLAQMPISDDRREILLSIAPQRLGYVPERLVDLVRESSSMDDLELSALLVLLIDCTRTQFGKNEWALGTREALCALMSSSIPIGSEKSFVALVSELMCIKASMWGVVRYVVSVEEKARSVGPTARRIIGLAFTNGSVIVRGQMLEHLTKLMLTYTEGKLDNTAKFNPLNPIRACLLSMHLVDEVPGQLFSDEDDIRSKWRSLWSSLGDAVKRYGTLSKNASEDDHQLAINCLLSIQATDAANGTSKDESDCQDYWRWLDGFKVEDSLFPDELIIALRFFIPTKEYGRFRRVRRLDDSKSDVGTDPRTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPV5</accession>
    <name>A0A2R6NPV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NPV5"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="99"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="28306" checksum="C9D197900AB74310" modified="2018-06-20" version="1">MADWLDALNTTMAGPSFIDRVRNAAADDDVPIRDDFGPILAQDIAEETSLQQLIRHWMNERHAPDILPAQEHLLGRLLDHIRKQSDDVQLLCADPDSSEEEHFRIILVQTEVERVKFVIRSYIRTRIHKIEKYAQYISATPDMHERLSQGELEHAQRYARLLESHFMNSVLQSLPLSQRGLDDDEPLSPAMITQPDRQRAVFAHARQACPPVRLPDGSTMEMEKDQISLTPYSVIEQLLARGEVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPZ5</accession>
    <name>A0A2R6NPZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v9759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPZ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NPZ5"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR74582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10258" checksum="5D0A5C49AF0EFD3A" modified="2018-06-20" version="1">MDALPESVQRLVEGKIDFEGQKRVDQITRVALVAITIVSFLVGFALQSLRATFGTFGSSTILLILVVVPQWPIYNHHPVTWLPVKEKEAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQV6</accession>
    <name>A0A2R6NQV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQV6"/>
    <dbReference type="STRING" id="98765.A0A2R6NQV6"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="123"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="300" mass="33305" checksum="EDBFE73C2A9BAC26" modified="2018-06-20" version="1">MAGSKRNKMKKLLSPTRALSPPQTADDEELMDDLLAELDSRDQSVQIQSATVLNDMQLEKVADDIDAAPKQDSKSRHKARQARRAAALADKFTPVDADADAKLEKEAREEERIINRTCDELGVKMHEINPDGHCLFSAVAEQLAILGILPSAEATYEATRRAAADYMQTHPDDFIPFLPSDSETGLMSPQEFENYCATVRDTAVWGGEPEIQALSRAYNVPIHVIQGESPHVVIHNPSDIPKTSDVKAEQVVRISYHRRMYGLGEPTISNWHPSKHYNSLRPKRSLTDGIKAIFSPSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQZ0</accession>
    <name>A0A2R6NQZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQZ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NQZ0"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="277" mass="30526" checksum="1072848555E6E4B0" modified="2018-06-20" version="1">MEAAFFPGALFLISKWYKRSELGVRTAILYCGNIISNAFGALIASGILDGMQGKLGRAAWRWLFYIEGSLTIFVAVCAIFILPDFPATTKRGGWLSEEERRLAMRRMEEDAGVGDEAETEVGGHAAGLVMALKDWKVWWMSLAMTSQVVCLSFNAYFPTLSATMGFGPTVSLLLCAPPFVFTAILAFFVSRHSDKTQKRFYYIVTSFFFGIVGFVIAICTMNTAARYVSLFLMAQCYAGFVVMYAWVSNTFPRPPSKRAVVLALVNAFSQLGNVAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQZ6</accession>
    <name>A0A2R6NQZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQZ6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7746" checksum="A80C32B1FD7DD63E" modified="2018-06-20" version="1">MKETKVNVRSASKLSKSPSSYGDDMSCTWWYTSEELNPMRLKRSQERKTVPNAGVEKTVEPRGRPIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRB6</accession>
    <name>A0A2R6NRB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB/POZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000921">
        <property type="protein sequence ID" value="PSR75184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRB6"/>
    <dbReference type="OrthoDB" id="3357985at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29603" checksum="AC85C89DC4410AD9" modified="2018-06-20" version="1">MFELSQPESTEGPLHFPLDGGRDLASTPVIEVTEDGRTLDSLLRICYPVRPPALDQMWHVEQVLEAATKYQMDWALHSTREALSRIAEEEPISVYAVACRYGLHVETSQAAQFSLSLPVTTVIDSLIHEGVAGEPFRVLMKYRSECQAAALSATETWLWTINMPKQFWTTHSCCTRTTVRDRTGRVYHVQPWWIRYITMVAKALRDTPSEDVVDVREALGLYMSDGRGTCGRCLSVAVDHITAFATKLSEEIAEGIAKIPFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS07</accession>
    <name>A0A2R6NS07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS07"/>
    <dbReference type="STRING" id="98765.A0A2R6NS07"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="233" mass="26709" checksum="A4CEEE4DEE8EB9EA" modified="2018-06-20" version="1">MFDISLEVEAKGELLNEDLTIASCLRRYTKPEKLGSNDYSCDKCGKASHASKRLSIRRLPPVLSFQFKRFEHPTTDKTSARKIESRVRIAARLNMAEFTTVALKTQEKGGKAGTPSTYPGPDAMYEYDLFSVICHEGQIDNGHYTCFTRYNDEWYRFDDEKVTHSSLGACLKSQAYMCFYVKRHLDYKPYVLPSYVKSAREAEAVKKEEEEKEREKEAAARLREVEDALLATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT65</accession>
    <name>A0A2R6NT65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT65"/>
    <dbReference type="OrthoDB" id="3245543at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11638" checksum="A6EB3774CC9FA030" modified="2018-06-20" version="1">MSFEPTLALSPSIDRKSDYIDETVEVPESLETTERPPIDYASFSSFTRSLWRRFVSLWTKRFIWSLIAGQVVSLCITCTNVATPELGMRNWALPTTQTWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTA7</accession>
    <name>A0A2R6NTA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000851">
        <property type="protein sequence ID" value="PSR76272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTA7"/>
    <dbReference type="OrthoDB" id="2794674at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="149" mass="16891" checksum="787C89BEA3578124" modified="2018-06-20" version="1">MTASVATYPYPRAQATTSARKYGRVKKTFLIPKAPEGARYCEEVNAMVPADLPYRIRGISIEPRKKTLVERLLRKEFKEDGEPLVIAMGLTHGKMELISLGEAQQSRDIVYRSVEKLDDGENFGRGFRTDLISLGEAKRRPEIVYRCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTH1</accession>
    <name>A0A2R6NTH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000850">
        <property type="protein sequence ID" value="PSR76297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTH1"/>
    <dbReference type="OrthoDB" id="2564465at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="166" mass="17960" checksum="DB4A92B6FC3E8FF2" modified="2018-06-20" version="1">MTGHCKMPYKAATEGSNTAAIVEANDPSITTTSITGTPSSPTTEDEHSNRRPLAERLLPKPRKTGVDDMLDTPDVPTLARVMRVDSSPRCWSVQVTSTPSRGPSSLSSSWTKKQRQNSARHAANKAAKVEIEAERLARLQREPEMARIAEQQSGVFGEEAANGACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTK8</accession>
    <name>A0A2R6NTK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000846">
        <property type="protein sequence ID" value="PSR76419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTK8"/>
    <dbReference type="OrthoDB" id="2984728at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10036" checksum="0AB5AEDACF7C7FAD" modified="2018-06-20" version="1">MEAGAIRAGFTEFIISPRRYTGVGTITPSISFRASEATLTGDPQDRVPQPFTGTIGPDTVNINLLDGCKIHGVLDVPTIDRTDVSGCITWSVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTV6</accession>
    <name>A0A2R6NTV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTV6"/>
    <dbReference type="STRING" id="98765.A0A2R6NTV6"/>
    <dbReference type="OrthoDB" id="2800235at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10172" checksum="7F271B1C03264EF5" modified="2018-06-20" version="1">MDDKWPRDAFLPFNAGPRACLGRRFTETESVAVIAMIVSRYKIDIKEDPKFAHETADQRRRRVLRSKPGLSMTPLKVPLVFRRRQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU26</accession>
    <name>A0A2R6NU26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU26"/>
    <dbReference type="STRING" id="98765.A0A2R6NU26"/>
    <dbReference type="OrthoDB" id="10010920at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="entry name" value="Large-conductance mechanosensitive channel, MscL, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266:SF2">
        <property type="entry name" value="LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="MECHANOSENSITIVE CHANNEL MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="Gated mechanosensitive channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20785" checksum="B938AA94B5A43D63" modified="2018-06-20" version="1">MSDDRENGQQSRLLNGTHTVIRRVHSAWSNFIDFLGRDNVLEVAVGLMIASSFTAVVNSLVSDVLLPPISLLPFMSHRNLPEKFWVLRKGPHGDEGYNTLNQAAEDGAVTMAYGVFLDKIFTFLSLGIVLYAIAQIYGVLSKDSIIKNTVKCPYCRKSISEKAQRCVNCTSWVDGREDRETTALATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUN0</accession>
    <name>A0A2R6NUN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v8089</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000815">
        <property type="protein sequence ID" value="PSR77056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NUN0"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="12">
        <location>
            <begin position="1329"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="897"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR77056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1639" mass="177241" checksum="9E354DFF3FB76C1B" modified="2018-06-20" version="1">MAAKQQNQPLDSTGCAALAEQPPRISLASPLLASAIDLPSQPLIVYSVYTPISGQPGVDPLYALEQARRRIVEKNSSRTVVDSLLPSVHLSRDSSVLYVFAFSSTHKPSASQTALQGAQFDDLILAESSQFSLTGLYPCSDPCSTQRTPCTTCLNPASPLATSSAPSSSQPPPAPWTSSACLLPRKPLRGPYSRFTQAVRDRLIDDVTRASKTARASATERAAVRLKGGFLLSSPASSSASEWGTGWDHYTLQRTLVHCELQIQLCSSRLLIHPILRPTHYLPLSNILPAPAGTPITLLPLGVPAYYLNIYSGPVGGLASQFDSALSGLGAGDWKNPGHFSQAVPSAIKDGMPSYAIVWLSVQNNQGEAKGIPLIWPARLCIALSTTAPHVRPPLEYIPSLPTQLQASPPALTAQDHPVKLVRRSLTPATVLSGAPSPFSEQTAPTISQRATSMPVSSEGGLLVPKPVRPVLSPRSPTSDSLRAFRALTLTNTDVGVIAQEVSSFVDAIMKDRERERERLRREREGSSSKLGANSIKPEKTEEPSQPSLLPSTEMHVDESVPLKAEDTVDAVHDYAFPTPEQRTSPADPYRTGPTTLDVLLPAAGITSASDVRQPSAVEPIKKEEAADGNDTTSESAVTPTSDPISYDSFPVFESNWGQHAGEFLTMDMGIDNFGVGFSVGMTGLGEMETNFGGFTDDDFNFFDAPAPNSRSFAATGSGLTPAAGPAPFGIPPPTLSTGMIPSGLGPPSGLSQAHPLPWMTQVLGEAFTPHSIDTPVSAMLPPPELLPATPALTPPSQSAPVTPVVMLLDRESITYRRNGSIGNLSPSAFDPIPFARSHKMADGKYLMGKFALPSPPDEEDRTQPIPITSRFRGSANYSAMTDPRIGMIRRLVGAKRKRGGCDDAGRGEKMSPSWIDEQDGWISSSPGNMLDTDMDDPRSESESGSDSGDLEGLFTEERDAKSVSRPHTPPPAYLPLGPTLVQTQFCHQYLLPLSIPLRPPGVGIQNPAATAPMSVPTPVSPAAVLGAMSEKSKALEDAAQILVKEVVENCVWATVWRANAVAAQGATNSSSKLWQVDVKSVHKLLSLSGIPSSLSLEEVFSDEVADTVSLQVLGRPLLSVGKSDSIIQVLPSALRFWEKLGLSPRSGSKDVVAFVFTDRYDEEKGRCVTTWLDRMSIVYAAKNFGKHSVGHAAECIVDGVVSVNFDAFRKMLPLFVENVTKSTDGNHCTVVLYVVLPAHIMNLASPVLRHVLSAIKRVNRKFKNSDILFQFIPEPFVVGSLDDPSANNSGLEPLVESLYDRIRLPARRTMSRKILPADEKKTRALFQEPAYTLARSLHSKVKFVREAHASTLDVMDRHTLLQVGYHISPCRKWLFAACTDQRAEAHNVRAWLMPTDSRESFVVARIWDFAQSMAMKASIEWHIVITKVGSMSATEFDAWISQLNSETFTNIDLPPVQTSILVAQPDDPWMFLAPEHAPVIKSPASTSRTPKVATGSVVQDISASFYILDTTLRPTIPSPSHEYVAERTCIPDAEEEEPTEELGLRSRSSITLIRVPAGTDYTPISMLHLHLLHSGRSTYSSAIESEVAILYDVTRNFSDLLTVTQHRWKLKANPLLPFHLAALEVMHATLDTGDVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV84</accession>
    <name>A0A2R6NV84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV84"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7791" checksum="397E85B30F7D09D7" modified="2018-06-20" version="1">MRKGPSFPHLISFWKHQQLITTGVGRDIRSPSPNLRDTREPRRVYESTNRQSDLQDDVDELYCCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVW8</accession>
    <name>A0A2R6NVW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v7650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000768">
        <property type="protein sequence ID" value="PSR77908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVW8"/>
    <dbReference type="STRING" id="98765.A0A2R6NVW8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR77908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32255" checksum="59617F1D8DD0606C" modified="2018-06-20" version="1">MFNRPAILALFVVLISAVIFSFFRGHRLRKIMPPSPPGLPVLGNILQLPRLNPWIQFTDWRYQYGPIYSLNVAGQAVIVLNSFDTVTDLLDRRSSIYSDRPRSIMAGEILGGGIILAFMGYGERWRRLRRIAFGGFTVRASVDYQPMQERESARLVAHLLRDPMQYDDHFKRNAASTVLTALYDRPLVDSTIDQVARDINEVAKSLSNAGAVGAYLVDIFPAMLYLPEWLARWKREGRQLHEKYSAMLEGFLLDVQNRLVGCVQPVPLFDCSIKISFFSRLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVX6</accession>
    <name>A0A2R6NVX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v7654</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000768">
        <property type="protein sequence ID" value="PSR77912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVX6"/>
    <dbReference type="STRING" id="98765.A0A2R6NVX6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR77912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20930" checksum="F37A4B21BBD85A3A" modified="2018-06-20" version="1">MTLYPDVLARAQKEIDEVVGRERMPNFDDEGSLPYINALIKEVLRWRPVLPLSTTHLAFFELELIHFMRRFAEEMRAGTTVLENVWAMAHDPEYFPDPDEFRPERYLDGDGKLSDSKTDTNAQKYFAFGFGRRLCAGKHLADQTVFIDIASFIWAFSVQKATDEKGLPITPSRDAIINDGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW05</accession>
    <name>A0A2R6NW05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v7628</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000765">
        <property type="protein sequence ID" value="PSR77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NW05"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="335"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="16">
        <location>
            <begin position="528"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="13">
        <location>
            <begin position="908"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="13">
        <location>
            <begin position="1088"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR77970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1480" mass="166826" checksum="F2D9C0DFB3D30B3F" modified="2018-06-20" version="1">MTINYQDTEALLPRRYQEEIFSRAQDRNVIAALDTGSGKTYISTLLIKWIATRDAGLGKTIVFLVPKVALVEQQGDFIAKEAPLRVSKCYGATAIDMTDRRGWRKEIEEHDVSLMVFDECHHTRKNHAYNGIMREYFQWPLEQRPKIFGMTASPIWNPKDAAESLATLERNLDAKVIAVREHVDELADHSPKPQEIIQEYAAPPLHYKKYPATTLWERLKLSELPPTIDFPITKIQTRYDVTLHSLGPYGAELYLYTDIKNRITQWVSQAEDELDYRSSTNYDTLTFSREIQLPPELDHMQTVLSQFSDIFEDENDPDTVPIRIDTNWCSPKVILLSQLLFEHYRQDFQGIVFVEQRHVAACLSKMLPRIPPLELYFKSAQLIGHGASSLQKSQGKGMALRTQQDVVRMFRDREINLLIATSVAEEGLDFPACELVIRFDPIQHMVGYIQSRGRARQKTATFVVMVQEGQAAQLDRYKAFSESEPQLRLVYQTRDDAPAPVAEDELEEGEEREDPDDLAERQRYVVESTGAILTYNTSIGLLNHLCSLIPRDRFTPMHLPQYSGDFEATLRLPSSLPLPPDKLVYIGPPRRSKKEAKRAVAFEAVKALHKLGVFDDYLLPARASSGDNEDADGRLIGDVSSIPDTMDVMVRDPWTRGRKQWLHVVYLDGRPTAGLITGSILPPADLVCNGTYVNTSDGSRVEFDWRDEWQQRRALEDFMRMGLWWSITGRGITLPMTCYLVPITRSLEVDWDAIYKAIANPYGVADWSGVGEEHYSHLLIICSKEHGRPLMLRRIRTDITPLSRPPPGSREAGYGTYRDYCLWKYTRKGVPPDVPFDGPCVEGQPFPRHTSTVYALDGSDTNQEVSANNNTHIYPLGLCRWAHLSEDVYHTFHVLPELCHRITDLYRARTIRLELGLPPIADDILIQALTLPSANAGFNNQRLETLGDAVLKLSTVVHLFNRFPHRHEGQLDVLRRNSVSNRTLLARAKEIRLEQYLTSEPQTMRIWRYVLPADSDLSVQLPSRYVLRRIPKRSLQDCMEATLGAGFVTGGISMALCAGMALGLSFGGPIPWPIRYERRPESPVSPLFAELQETLGYQFTCGALLVEAVTHPSFRSIDSSSYQRLEFLGDALIDLVVMRYLYNKFPEANSGQLSWARSRSVCAPALASVAVNHLGLHKMLLVNNVELSIAIGKYIPILESTSSEEIIRNGWKHDPPKAISDVLESVLGAVFVDMNFDFEKAAVIVESVLQDLLVVLSPDMPRDPVSELMSRSELKKNDSVSIIVHDFAVVGPIPASNMSLAKGLASERAKQVLADPQGPYLLATICDCNARAAVEEPPELAVIEEEPQKLDDETEEGFAALARIALTKIAGAEECQQDDVGIPVEDEDLEEEFRGPQIQNVVAADELGEQMMDLESEDGLEDVPYKDESESLAKANEILDKFIYQETGNRLPIPVSSERLYGEPLRAYGLQPISSFQAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWS0</accession>
    <name>A0A2R6NWS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWS0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6961" checksum="CA97149C7999E8B9" modified="2018-06-20" version="1">MSRCKNTVTITKNGNAPRLVEGDPAIHLQDLSIKSVLKHTNVSLYLQRQQNISEVEFVLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWY2</accession>
    <name>A0A2R6NWY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWY2"/>
    <dbReference type="STRING" id="98765.A0A2R6NWY2"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015329400" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="306" mass="32169" checksum="C85B102A4BC57ED6" modified="2018-06-20" version="1">MNLMALTLIILIVSWEYPNKQGLGCNVISEDDTSNFLAFLQELRSHEGAQNLTLSAASSIVPFAGPDGLPSKDVSGFAQVLDYVEIMNYDIWGSWSNAVGPNAPLNDSCALPANQQGSAVSAIEAWTQAGLPANQLILGVASYGHSYYVDKNDAITMTSPQASSAGYASPPGAAPLAAYPPFDKAQQPLGDSWDSNAPAGVDLCGNSGSGGPSGIFNFFGLIEKGYLDVNGTALPGTGFRYDDCSQTPYVYDPQSQTMVSYDDTQSFAAKGKFIADASLAGFAIWEVAGDSRDMLLDAISSAIVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXE4</accession>
    <name>A0A2R6NXE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXE4"/>
    <dbReference type="STRING" id="98765.A0A2R6NXE4"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18352" checksum="619E9F9CF36F786B" modified="2018-06-20" version="1">MSTASATAHTPTTPLAAIPSVPNLTGLMPSELEHTLTSLSSNRTVLGYMLLSRSQPVTIIRHSGVVFDGEQGRNYAGVVSRVVESVRVGLEEVSGDLGDTDELRFMRIRTKRHEIMISPGECPWTRFSTKTYEGAGRRTISLSGIARPDIIATSTEAYQGLVLCYKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY82</accession>
    <name>A0A2R6NY82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v6879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000681">
        <property type="protein sequence ID" value="PSR79833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY82"/>
    <dbReference type="STRING" id="98765.A0A2R6NY82"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR79833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33144" checksum="9FD28A3BB1992C77" modified="2018-06-20" version="1">MKWGLVPHWSKHEDNTLRTINARSENLVKGGGMWGSIKGRKRCAVPCEGYYEWLKKGKEKLPHFTKRQDGKLMLLAGLYDCVTLEGQTKPLWTFTIVTTDANEESRWLHDRQPVILSTDMSLQVWLDTTSKIWTSELSKLVEPYSDMNSPLTCYQVSKEVGKIGVESATFIQPVSQREDGIQAMFAKQQGKGSPSKRKRSLSPKFVEISPRPSPSKVRKYKEHISPPSASTNVIDFCEGGDEPRKPKVEKLNTWEDDSETEYVDGSSQSDSEIPNHESRKGKAKLGHMKVSGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYF6</accession>
    <name>A0A2R6NYF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v6771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000658">
        <property type="protein sequence ID" value="PSR80299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYF6"/>
    <dbReference type="STRING" id="98765.A0A2R6NYF6"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR80299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="522" mass="57441" checksum="01E5864331408906" modified="2018-06-20" version="1">MTSPLTYPDIHGWNLSPQDMSSPVIAHTPVSTREMPTSSSSLPLPPSRKPSRSVPAGRNSRRHTDPPQPPRPRNSFIIFRCEFQREYSERVKASNRSPTPEKMLSKRAGVIWKNMSLEDQKKYRDAAKEEAIEHLVKYPNYKFRPRQRSRPKRRSTGTVNRRESIKSLMREHSSGSQMESGSECERPTSVLSSSPEPTAEDYPHTLSHRRSMSLPHLGPYRFTRTHFIEPVSCASSPGTGPHWWSSRSSSASTREPSPRLPPITLRSHDFEIDPGLDAVPFMSVAARSSTSSLGEMVALPECVPSEGMHNIGFSSAQTSPMAPVHESNLFGYFPAPPATSVPLQHRRHRSNTAPSSYLSPLAVVSSSLENWNGEMTATAAATSRPGFMSITDTSAALTPTATSLPVTSHSTGDYSYFGGPFVSEPSASSFLTLDTEIDFDRTPRRADFAFGIQDLPMSQPGIDSTSHRPGVNGAGGFASSFGPSYELDSYKMGLDAHSITPAMCDLSFQGDHFDDLFYMGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYH4</accession>
    <name>A0A2R6NYH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000659">
        <property type="protein sequence ID" value="PSR80266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYH4"/>
    <dbReference type="OrthoDB" id="3270129at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="36106" checksum="6FF61A34A14F76F6" modified="2018-06-20" version="1">MGRPIQDITLDDDSTVDWQLVPDSFGGVCNWAEVIKDEEDCSLGTRYRLVYKHRGENDMLHEVCIRAQGFVKTQTLGVLGNWNGSARNTEEDLSSIRFRNRVFTKVQPGIANQPRSILDIGDDPEGKAAKVQSQWVVLHPVQYGLEQVTGEQVPCSAWTFQKGDFVDVGFTLDIVTNYVKNKKVTDIAFMMQAVLLLRPACEVQALNMTPDAINSTKKPATILITNSGLQMNKRKRTDDDSDDTVVSKKSKAGLHHEYARAEGSKISNEVMADELNRTKSSKFLIDGIVDDSERAECSKVASDCMVDERERAEGSKLPSDVMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYQ2</accession>
    <name>A0A2R6NYQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Laminin IV type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v6610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NYQ2"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Laminin IV type B" evidence="11">
        <location>
            <begin position="226"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR80694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="363" mass="41202" checksum="5F896DBFB3B0DFF1" modified="2018-06-20" version="1">MSTTTTATETVPGSISVQAHEDKPVSEQYKYAHLFPVFQKDEHYPPLTPFEHVDPGHRALKHENPRSFLANAKVTQLTPPIGEEVRGVNLATLDDTAKDQLALEVARRGVVVFRDQQDFINSPPETYLEWGRYFGRLHIHPTSGHPEGFPHLHLVYRDGKSSFNYELSDRTTATTWHSDVSYELQPPGLTTLFLVAAPESGGDTIFTSQVTTLKRLSPDFVAVLRTLKAVHSGYEQADYSRSGKRGGVIRRDPVEHVHPVVRKHPVTGEESLYVNRQFTRRIVGFKREESDAILNFLYDHIDRSIDSQVRTKWEPYTVVLWDNRVTAHSAILDFIETSERRHGVRITPQAERPIPALEGLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYT3</accession>
    <name>A0A2R6NYT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYT3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5622" checksum="A2E49EED6EB96D69" modified="2018-06-20" version="1">MYGVLDAGSYNSSLGRHLLAIITTHDSWSQSWSSTTKMTKDGVFSRLNGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYV0</accession>
    <name>A0A2R6NYV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v6632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NYV0"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="1551"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="2068"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="797"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="847"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1396"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1479"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR80716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2167" mass="242279" checksum="E310414FA38533C6" modified="2018-06-20" version="1">MDELVHHCIRELAFEGDLGCDASRLQGFIVGFYEHSTAVQNVDEAFCAFVWSMIVQQPEVRVGIAPEGASEVYIAPQQSKTPGANKGKGKKKKGDVDTVDESSTLASLDPVPDASVKSLGDLKAEYGEALRIAVDPQKSFVAITGSHIRPSKLTPMVYTALQLVSRGRENGISVVDLSKKTGYDPKTCHYLVDKLLELNLIEKRKKSGVGANFCIHKYFYERSEIWKIVQAEEDEANQAFLPKAEEVADDVEDLTLASNLGAIHFDPIDTRHLSSLPLIRARLEKLLKNSPHHMHAAQNLLVTIGFPNPVKAERRFFQTRLRELIAQGVLEKVQVPRPNGKYVQCIRLLAPDTADDHEGGNVPLVEGMDDEENEEVLPALKANVSFHKQVIDLVEQSGAEGIVLNALSKGLCNFDKRIVDHQLTRLQNPHPPPHLFDLGIAQLGESHGRERRYKYFTIANYQIVAAREKLDARFPDSSFSQVGDFMLYNETQFYKDADDFAHYVDNFPSKEFIGDPASAKKKSKKQSKNPVLADGSVKKGRPRKSVVMEEAAVDTPTKPSRGKRKRDDDADAVVRSPEGPSTSSVVAPPPPKKRRGRPPKQKVTEEAEEQTPVVLEEEPVPEEAIATPKKRGRPPKNKPQNVEDATPASALEKQRRPPKQPEAAILVTNPADVDTEEVAEDSGVLDNEVVSPNWRLEDFEVSHVRNEVFQSNRGRPSTQSLTLNSESVTSPVPRRSTRTAKPKAREDDGTMSVGTRSKRVEPHSTQVPAPMLDALPSQPPRSRIGKSFAAPRSDLTATGFTSRAIPSSGPWSSTYGGGHSDASHPDTFPLDPALLEHSPAALTVQQPQASRTSNVTEPHITSTPPSRTTLPEANERKRAEPDTPTFLPSLKRTKTYTPGTGYRSRANISQSRREKELLRVITDFGGIANISTKEFFEAHAALIESLSKAGEAVSTRLGSRIDKRTLDTALRDLESQGKIRLVTTQVTSIGGVTRQVKIAHFPDVQLDVLNEFLADVGRSQQNILQATIKTLEEPMEYGGSKFQKIARPQASAVLLNLDTDGDKDSEKVVELLRLDDGTIQASLLTEPATVMQLYNFIVGKMARVRKLHLHMLEIFEEASIPSIVSAEKRIIHLPYFFQDIPISVYCAVVSCRTQNTELMQLLSTDEGRSTPVGQLSSNITEELELAKSRSRGRILDLFGMLQSLHLIVPLRVSEAERPWLQCAFNGGHPTRFEVTTYEGSATLSAPQYWCFTPDAPLHLWALDERSPAFWRNASVRSVAEGKVFWRELERISIDADYCDQLMPDARANQVPADAPAGIAKLLRRSTQWKSSYNFSWFQRQYLRHHMDESNGNTPLQDEQNGEARLISIAKVVTAPKDEVARFYEHERTRIMREIARSTEKKQKEANERNRRRAEEKTLALKAAEAKAQREKDWDDMLRRVHPEPLKGPSVTRIRHLRTRFLQGAGTDHQKWETEIRSTIEEAKIPAKRANPPRPTTSSNHESSTQPVPAPPSLFIGSHERSIEDLIAAQGPHLAERLNNQAKKDKDSASRRRHRFQWTKDYDELARDASIIIKARCRDGKRLDWAGLEQAFPAIPRNSVRQRIGHLREQQGAEAYFKRLEDRWYELWLRHRGTPELPDDDPGSPTNFEMIAHLKFLRDHIDKNALRVGFLETEQPVNVALPHTVAALEESWEIKEQVPTAPSWDFMWNGAAEEGREKQVAQQSFVLGGNQLPPSRSYPSESIYVADIALKMTLGTPNESYDTDHASCLLRSAGDTSVKRAMAELLERGVVSKLVRDPSKPKPGRTLKISETNQNAIGGSIAGELFQDAAALEDLLSQREEEPSWREWPLIASDGDTATLLQLVSENKIDFKIDTTHVQATRLTIDWNSKKADDDDIETAFLVRLSDAPRRNDRLPTASEDMEVQATPVEWEPTQSTGLLGNHGKTISGEQACCRKSTSGLVDCVACLTSESSKLIEGCLDEPKSRLLSRVLEVLAQAGSDGVTKTQLAQVDPDAVQWLPETIALLTNSNTPLAFWTGYTEVVLVSSLHLQTWTVIVSQNEDTCVRVLPRRWLDIHGREIPEVWEAACRAVIGVIAFRPGISQAEIRWRLRSVYDRHEVGELLEHLLEGRYVRRCVVEGENLFDDSPANNSEEKTTHWMVGEKHWYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYX6</accession>
    <name>A0A2R6NYX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000640">
        <property type="protein sequence ID" value="PSR80803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYX6"/>
    <dbReference type="STRING" id="98765.A0A2R6NYX6"/>
    <dbReference type="OrthoDB" id="2418900at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="378" mass="42621" checksum="3DD483AA8FD1AD12" modified="2018-06-20" version="1">MTAHGDLRHFKKGISLISQWTGTEYKNMEKVFLGVITGCADVGVLRAVRAVLDFIYYAHFEVHTAESVANLDAAWNAFHSNKDIFVKLGIQKHFNIPKLHSMGHYYPTIRKLGALDGYSTEGPERLHIDFAKRGYRASNRRQYIKQMTVWLERQEVIYRFEAYLRWTHGQSIHDTGEDQKAGAEEQDDNLEDDDLASEKSANEVVDENEPEDNLKIRSTTYSIAKRPAFPRTSVKSLKEHFGAPDFLYCLDDYLRKMYNSAQSRAQIQPSTRIDDLSTLRVYSQFKVQLPLMSQVSQDIINDTVRAAPEQTEKGAKAAVPSQFSTVLAREGSMKIAADGNPLEGTSLPPPAIALSEPRVSAIWIRFACCSSACNFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYZ5</accession>
    <name>A0A2R6NYZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v6810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000670">
        <property type="protein sequence ID" value="PSR80080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYZ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NYZ5"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="11">
        <location>
            <begin position="54"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="684"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="786"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR80080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="916" mass="101412" checksum="16EB21ED8EA5E237" modified="2018-06-20" version="1">MSVDSLSTDPSGMSSLTSVGDHGSVGLSDPMYSSSRRKMLDLVNKLHSTGVQSDVDLPMIAVIGSQSAGKSSLIESISGITLPRASGTCTRCPTECRLSSTSEPWMCTVSLHFITDEHGKPLGQARNDRFGGPMFDKSEVEERIRRAQRAILNPNTLSMRFLEGPDEDPIGRELTFSMNSICLQISGSDVADLSFCDLPGMIASGVDKEIIENLVTAYIKKSSCIILLTVACETDWENQRGFDLAQTYDPEGKRTIGVLTKPDRIPPGKEERWIRFIKDEDKPLENGWFSVKQPDSKALQQGISWSEARAKEREYFGFTQCWSSLEFAYQQYLGTANLTERLSDILSALINKRLLELQDEPQKLIQRKVTGSLEPVAPLELSVNRWTPGSLSKKPQAVNEDSPEVVDRKVKGLLNKLTTEKFDSISDQIIAWANRSEKEKDGRTLIQVVRLVFENATDEATWSEMYARLCRKMMEQISPKVQDDGIRNPEGKHITGGHLFRKYLLNRCQEDFERGWASKESTEAAAATKASEDAKVAANGDEGEEAALYLEEYYAAQKAKRQGLGLIRFIGELFKLQMLTERIMHECVKKLLGNVENPEEEEIESLCTLLTTVGALLDTQKAHAHMDVYFSRMKELTKSPNVNSHMQFMLQDITELRERKWIPRNLAAALTTLAAVHEAAAKDKEKEQYQRTLSMSRGGSRRGGDRGEYQVGPDGWAVAGSTQPRAPPKAGDLSNFGKINKTTSMSFGPSSIFAAGKKESKRDSMISCTGSMNMFSMFSQNAELANETQPLAKSSRPPSRKSGIDLGSGGAPEAQAAPMQRRKLNLLTRSVQKSDDKSEETPAASATGSEDEGATFEEGFTPTAEILDAVAIDVPNAYPLFVTMAKGAGLNKDEERYIRFASKSWDNNKLLHMLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0N5</accession>
    <name>A0A2R6P0N5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0N5"/>
    <dbReference type="STRING" id="98765.A0A2R6P0N5"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR82609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9171" checksum="188CC50C544420A0" modified="2018-06-20" version="1">MSRTAKATLLGSVLVAGGIIWGVHFMQQREADNMYQGVLRDDERRREKMRKREEEYLESQRKRAVYERVQYVPSHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Z7</accession>
    <name>A0A2R6P1Z7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v5591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Z7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1Z7"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR83882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="824" mass="91305" checksum="A97A423B78301EF7" modified="2018-06-20" version="1">MSDRTRAQGGSFLYSDTQDDQQKISAPKQHPYRPLVASSSRHAPPQHSPSYVDMFHDPARLHQDGSYGGPPDENSRNIVAVSQDYHHPQSYRDHYTQMNSSSLYSTADNSVMHNFPSTSHPGRPDLHPVASRSISSHSPSALTEQHSPAQDRSPTLPRSISKRREKPRIELSPDQPLTTQGKPRARVYVACVQCRQRKIRCDGAKPICHNCSRRVSSNAEELTPCSYDPAPKRRGPDKNPGSRQRVSAQEITDGGKVRRRRRREAGPSDRAFPMTAHVSTPSTVAANGVLNPMLTQIQGPNALTSAEALTRAPAENRSNVYGKPDLYHGAQQQHGIAQTDTLNSNSSSHAASVRHLSHQSDALQRIVTVNEPQFPQVPVHASPLQQYSPISTPLSDLTYVGYLPVSGSAISCVAEEYDDDAERKPEIGAEPSLQFARETWWDTLLGLYSMQVQPQGGSVSILTPGRRDSVSQQITSDLRFLFKASNYWFSFVNVPRFFARLMDPITRSRLQPSLVLAAVAVANFIRSSEQENGKNGRTWALTLRDRAQSALEASLNARWVDESLVQASWLIAFFEISAHPLHSTVRVRSSLSMLDSLVRSLAMPSLDQDDHRASVFASHTVPTVVSSPSVSPPISPWNSRLPQPVSAARPSSPPGECTCAAYTLGNNWSHAQELTPLWLMTPAWNRDSSDAEVRKEESRRVVWSAVTLVAGYTSYTSASNPLPTMDLFLMNAANYALLFPGESLVATSSGPSRKETVWALYMRTMLLWHTCIRMRSNTILGDPEKAQFAVSAWLEVDKIEEALNSHTCGIERAFLFQGREYLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5G7</accession>
    <name>A0A2R6P5G7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v5317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5G7"/>
    <dbReference type="STRING" id="98765.A0A2R6P5G7"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR85841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="349" mass="39634" checksum="781B858CD3D6CFFE" modified="2018-06-20" version="1">MSRTKTQKPLPKFEIGDDYRILHGLGEGAYGTVAAAVHIPTGKEVAIKKVLPFEHTLFCLRTLRELKLLKFFSETCVNENIICILDIIKPPTLDAFTEIYFIQELMQTDLHRVIRTQQLTDDHCQVSQPSIFCYVTPPPPDWFVNHSQYFVYQTLRALKTMHSADIVHRDLKPANLLLNANCDLKVCDFGLARSTRSTSPGGKEAGLMTEYVATRWYRAPEIMLSFKMYTKAIDIWAVGCILAELLTGRPIFPGRDYGHQLDLILDVIGEYINVRHAAVLFLTVGDVRAPGTPTLEEFYGITSRRSRDYIRALPIRKRRPFSKLFPDASAEALDFLAKTLVSVVLRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8P7</accession>
    <name>A0A2R6P8P7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000520">
        <property type="protein sequence ID" value="PSR87019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8P7"/>
    <dbReference type="STRING" id="98765.A0A2R6P8P7"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015353349" description="BRCT domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="4">
        <location>
            <begin position="276"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="1">
        <location>
            <position position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR87019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="688" mass="76614" checksum="3A7022646B4F51FE" modified="2018-06-20" version="1">MNKLLPSLILLYLILKAKAVNGRCFNAISKAQCAYMLIASHSWGPIVSEIFQSDAADSIPVQRGGRAQPPFRTNNIPSEKALLASPGNVQLSDVDVFDKGDEVRMNKASRYNSEVNDTSRVVSNKGTRVPGLNQKQQCPAAVTAAIPDGLTLLPIATTLPAEPKTITDVAAGLEFMKRSVANNASKIARAPKSVPMTAADSSVITTPASSAKSNAASTSPARNASAGASTSRTRKSTTSALVKKTKSKKEKSVLMLPCDYARKLQQMVASGEMRLYSKRYLEGKIIYYFGGDFDVATQRTREKMEFLIRHGATLLPQFDPERVTHIISDGPKATFLHSIGVKKIADIHPNIPILKWNWASRSMDNPGRMRQYQDFAAYPERVLFDPEVELQLARARNAKDRKGKGKARAPEPEVHDSESDEEYSRISEFTQDKIPNQVISDNMPRPHPERLVGGSQTSRSSDIHLNDRRLEEMNGNAPVQREDDRRSPSAAAAHRGMDDDPLAEFYTQACAELDAERYKDGEGREDNRPNGTENEKRTNVSSGVDGKFRPEEKRAAVFQCDRKRSELPVTCPNQDVIDKLSELKALHESKLGDDHKWRVYTYNKAIGFLRNHPKRITSIEEARQLRGIGEKTAQKVNIMRPLQYPLYSSQSLQIMEVIQTGDLRRIQYERTEDVEAVKIFTGIYGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMV0</accession>
    <name>A0A2R6PMV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMV0"/>
    <dbReference type="STRING" id="98765.A0A2R6PMV0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR93739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10682" checksum="1DD1A724BDFB6290" modified="2018-06-20" version="1">MSIVLDGFAATLKIRKLENNGTVHGRLPIIALTANVTAESEEKCRFVGMDHFLPKPFRMDGDYFLIMSKHFSKTDQLRTDFRAMLARIQHIAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNG7</accession>
    <name>A0A2R6PNG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000453">
        <property type="protein sequence ID" value="PSR94363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNG7"/>
    <dbReference type="STRING" id="98765.A0A2R6PNG7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="20869" checksum="FB060AA072D5A516" modified="2018-06-20" version="1">MVNTEPAGRRHAKKTKEVRSAARAAFKEKENMFWKEVDTLRKHNTTEISRIAREYDKTEKHVRVQLYRGGQLLVSKQKPSLRNAVLRDLAKQQKENGRPSEGRNTIIKLSKSISTAEIDVLPAEEKDRLIQALIEDKSEKATVTKVNEGLIGRDIEHTMSRVEPEVSLLKSTRETETLNPLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PV70</accession>
    <name>A0A2R6PV70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v4362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PV70"/>
    <dbReference type="STRING" id="98765.A0A2R6PV70"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR97081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58188" checksum="2B33BBB7B1C83E0E" modified="2018-06-20" version="1">MTSTTRHFWAAYLDDLAYPSVSLAVVTGILSWFLWVVVNGAYNLYLHPLSKFPGPKLAAFTIWWKIYVELIQKKDLVEMLFELHAVYGDVVRIAPNELHFAKPSVYHEIHSPRNRWSKDPVLYNAFAEFESSFTIPEYHRAKKRKDILQPLFSRKSIISMQHLIQDCMDQMCEGIAKQHGEGKSTNILLAFRCLAVDTITSFCFAKPANALAAPDFQAPIERAMTLSLPMVTFIKYFPAIKTFVAHCPPLLVSLLKPGLIGLVNMRKTLWEQVLEVTKHPETLESASHPIIYHALLNPASGHEIPSFTSLRDEALLLVFAGTDTASNTLTLGTIHILSNPDIHKNVVRELLEAWPRLDDTPRYEALDSLPYLRAIVKESLRLVQGVVTPMTRVVPAEGAELGGRHIPGETIVGISNSFVLLDGSIFPDPHSFRPERWLEPSSESLDHWLVTFCKGPRSCLGVNLGYCELFLGFANLFRRFELELDGVSAKSLRWKEAYLPHYEGPDLYVRAAPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ06</accession>
    <name>A0A2R6PZ06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000421">
        <property type="protein sequence ID" value="PSR99308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ06"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ06"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR99308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1047" mass="116532" checksum="6395D9010455FD10" modified="2018-06-20" version="1">MATLIRPRVSSHEPHDTYHDFALNVPKPFPSRAEREQEDLLESLESEELQLDDAVSSTHPRAHIEQTGALVSGPNPDASSEVVLNHRSEDLLPSIGQVQTSCLTTLNDLLSVSSKWTPIVPDRRHSLPPKSLASSSAGLSPSATTQPSSALQTLVSNLRLREQDSHNERIQEANTLSEADLLCEVRARVERIMTTLPPHDAELARTLVALLTHFSRLSVLSPSSTQPRVASWSAINNQQASSHGDPYASLTRQVSDFQLERSWSHGSPVPSGSRTPVVTVETALLWSHIDEELENVLSLCRPRSGPLESRPPEYDPADYEREFDLDSLPEYEPSSEVTDGSGKPLYKVNNALERSNTRLSESAYTNEKMRMDLEAVTLAIDRLYLVAPQLHNQRVELKKSKVEQMEKAKLKGNQKGKQKGKEGEMDAMELDRMLDLIGKAADRKMVNQAVFVDSAFSEKLARAQVEDLKKRAAFVEQLAKHSDAGRLHSQDAVFLAPVRTRSQPQLASELQDPHALLTLPEFIREGIPEPVEERMEAELDPEALLTLPEFIKQYPQPEPVRPAHTPRGQSISHWYLGSRQQHDESPPATVRPTKSNRSRSMSEPLSWLLSGSSSRSSSPSSASGPVLKKPRSGRLSRPKSSNDNRNIPTVHEGLDVSYVAEFHENLYHVLVFVSVTGLQPGHDLEAEVLSPDDSSNGRERLLLKCGGSTSIPLSLPTKVHTGKVDVSVIGGRHYQIKLPAAVTPQYGGKSISPVDPAITELLDATYFQTIQPTSFVCSSCSLPLVQASKLNEYRDLPSEHWAELVDAWMCHSDQALHEHVQKGSKDGFWPNEGELLVGGSYVLLREDTMVKANFCDIESTNKSSDEWFRVRCLCGAIVGRYQEHKTAEGSTVVYRLPKYAFRPISPIAEPSKVPLSAFIVEDMNEFVHAHATYRFVIADEEEERPRILVWLFKPNMRLAYATPAQYVIPRSGAIRAAKVLFKVLGPTEPSNLPTILNKYPGFPQAEYLYYPRDICRRLAALLKESNTAYPDSMRTMTGLDVGWLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZK7</accession>
    <name>A0A2R6PZK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZK7"/>
    <dbReference type="STRING" id="98765.A0A2R6PZK7"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="242"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR99038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="331" mass="35552" checksum="D1B8EBEABF024388" modified="2018-06-20" version="1">MAPSNLQGLNIVHTAPPQNPYLSDHDLLSVPPFPDLSAQLDLWTNLNFQSDEPLISRKDAHSQKRRGSVTTNDDVEDGDRYNMSEEELQNTGKVAETQSHENVVTGTIIPPQPAQAQGGGPHLPPFDIGSILAGFGIDPFQMPSSVSSIPPPAVTPSLAQLLSFHSAAPMRPLTIPTSQPATQTGPSQPSTPVEQATNVSYPAPKRARTSRSSISESPSEVTSPISPDADETPSTTPLTAAEDKRRRNTAASARFRLKKKEREAALEKKAKELEVRVSELEKECEALRRENGWLKGLVVGVTGAGAVQQQQTGAGMKRGRDELEGHAGQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB48</accession>
    <name>A0A2R6QB48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000374">
        <property type="protein sequence ID" value="PSS05363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB48"/>
    <dbReference type="STRING" id="98765.A0A2R6QB48"/>
    <dbReference type="OrthoDB" id="2803256at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="446" mass="50140" checksum="34835D443D8858FD" modified="2018-06-20" version="1">MNIDESSTTGNAEVVDTVFTELGHDFNSRQFCDTVRIVNRDQLSIARLRGSRNNHVGHDSIRRLYLNLILANGLFHSQLHIAFGTLETHWGNPSLGQNDPGSLSFHDTVLNRKPIILSSLPPYRTCCELVLVSLYARLEVITKSRLEDYGKKVTFCQLEIDATAILDRFASGSVVDKLCTEHGTTEAGTLPAGDMVYENAILMLRDGLIMQEFSDAIKCGNSGRIILSLQTLALYYCGSGRTKYAYEILVLCHNLKHVWPKPLRDIVIKNWLVNPTGHADGFVPVDLLQEHMNLWIKVNSTLGDKQGTKHHEPDLTNDISELMKVLHTHQVYTPIIGRTIDGDKALVRNVLVAGLHGLKKPLKEYNKLFERLRTRRKVMPLILDGWQGVPEQQLIMSDSTVYGQPESMVDADVDVSIPEDVTGSDEEMALEAFFALEEKDHELIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB96</accession>
    <name>A0A2R6QB96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB96"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="6245" checksum="6467295CAB75B56F" modified="2018-06-20" version="1">MRHKSYEPQRELQRYYMYNVYINDSMRTTENKGKIDVMRGDWHQIYRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBA6</accession>
    <name>A0A2R6QBA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBA6"/>
    <dbReference type="STRING" id="98765.A0A2R6QBA6"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015331323" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS05423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="383" mass="39842" checksum="3A2476AF0F8019F8" modified="2018-06-20" version="1">MSIRYMIMTLPLLYTRVLADFTPTTPGPGETYNAGSNCTITWDVDNSGTWTNITIDLKSGSNSNMSLVTNVASGLDGTDPSLTPFTWTCPEVDPYSAIYFYQIASLTDDSVTPEYPQQPNGDNIPWGEGQLASSGDGSADVESAEDVNDSANAADIQNLSKAKNKEDSDDDSADNEDHKTSGGEDDSNSGDDSGSSEDQADDGDQENAPPPNRHGRNKDSPTASGSSEAPSASAQAKAGSKTKAEATSDNENTEDTETTSTSIASTKRSNPTKTSTNLRTATTGSLVDPSADAAAESVTDSGSSTALAPTPTPGLPRSQKKVHASTAFTSSAAGQPTTSSDCQCSDQVQRTGAAKLMSGGRGRERSSAWAQLSSLSIIFLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBQ0</accession>
    <name>A0A2R6QBQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000367">
        <property type="protein sequence ID" value="PSS05546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBQ0"/>
    <dbReference type="STRING" id="98765.A0A2R6QBQ0"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33369" checksum="8A5036360107ED4D" modified="2018-06-20" version="1">MARNALSAFMQRANISIRGLICDPDGVLERRVREIVEGWDLGVPPKRYEPHLMASVNISAAAYGHTPLDVQVHIALYTLMAICVDDFNVDTHALQEFSTRLHAGLPQLHPVLEYLVYTLHHMSDFYLPYACKVITTASTEFVDMTLFEKETEDMPLSGDALRWAEHKRVCNGIGEAYALFIYDKFSFPDIATHIQANTDIALLTAYMNDIFSFYKEELAGETRNFIHDRAVTTNKSVSAALTDTVDEIVAAAQTARRILQGQKEKDVLGRFMAGYAAFHFHSTRYHLKDLMGSELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEG1</accession>
    <name>A0A2R6QEG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v3668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000361">
        <property type="protein sequence ID" value="PSS06538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEG1"/>
    <dbReference type="STRING" id="98765.A0A2R6QEG1"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="34"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS06538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="175" mass="20309" checksum="3773CD120E5B1FCB" modified="2018-06-20" version="1">MTTVSPFARSSVFEDARITGREQTIEEMYSVPESFLEIEVRNPQTHGFGRKMYTDYEIVCKTNIPAFKLRHSVVRRRYSDFEAFRDILERESTRVNIPPLPGKVFTNRFSDEVIESRREGLERFLSIVAGHPLLQVPLIISILPYCMLTQPSYQTGSKVLCAFLQDPAWDKSQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEG2</accession>
    <name>A0A2R6QEG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000364">
        <property type="protein sequence ID" value="PSS06501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEG2"/>
    <dbReference type="STRING" id="98765.A0A2R6QEG2"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="112" mass="12714" checksum="75600E16CAD92997" modified="2018-06-20" version="1">MPRFKLVFFSPVKDTPRILNHLFSKYPQEVGKIGQYENCAFVSPGTGQFKPRPGASPAIGTPGLLEFVEENRVEVVVNDRGGNEEVRNAIKELKNAHPYEEVAYEVYRLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEJ5</accession>
    <name>A0A2R6QEJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEJ5"/>
    <dbReference type="STRING" id="98765.A0A2R6QEJ5"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="248" mass="27524" checksum="FA2858361A5C7B84" modified="2018-06-20" version="1">MPAPGRQSGSPPHNITPMRFAPLPEQSVRTALILNRFSVNCNIQYCSNDSILSSSDCITRCFFDFVAKRDEDLVRSWIDVIKTWGVNERGQPSDGGFGFGKFTLLINGRDSIESSNEFLPPSRRQNSYPNSRRPRSPGQRHGEHARARDHDRGHGYDRHRHWPPSDRLHEEEEQLVVDAIFSAHSDGLMVIIRKSTATSSTPSTLPSTMTLPPPPMTRPSRSSSSQGSSSSGSSFSPYTLSSVRRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEV4</accession>
    <name>A0A2R6QEV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000359">
        <property type="protein sequence ID" value="PSS06612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEV4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="188" mass="21280" checksum="60B44840B6512423" modified="2018-06-20" version="1" fragment="single">DGNVKENTLDKQKTAWNKCSLQANKSKRRNNQIKGKIRITTPDTCNRTAIERTIQSSSTSSAYTAAGDAQDEWQVCQYLYPLILRRYRWMITNVRDRAALQRRMSTCDAPITINVLKARADEMRKPSDIVQKMVQMNGGMTSLLTDAVMTEFEEFEQENVLGMVCKPLGGPGCVPQSEMLTARLEILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEZ9</accession>
    <name>A0A2R6QEZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000351">
        <property type="protein sequence ID" value="PSS06865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEZ9"/>
    <dbReference type="OrthoDB" id="2645319at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="28569" checksum="9355B2108AEA5D79" modified="2018-06-20" version="1">MSILNANFHTKPYEYSGLAFEELPHLAKYYLEEIVGITSPADVPEEHIENEISKLFYTLFRTLQGNDMALVEELWGQTQAGPAVAKIEPTTPRSLSPPETQATEENVSQLRIETLLLPEREMLMSEFITKFDALVWLLMEQDDETKKLSVPEQQEFRDKRCYEAVRYTEQALLSLSQAVMQKHQAKVSSELSGRQVFMDNRQGRMNRREIEPTRNWVARTGTRRPSDSQPSFTGLEQREVRTGRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF18</accession>
    <name>A0A2R6QF18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NSA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000348">
        <property type="protein sequence ID" value="PSS06885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QF18"/>
    <dbReference type="STRING" id="98765.A0A2R6QF18"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22857">
        <property type="entry name" value="WDR74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS06885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="412" mass="45223" checksum="8663B40ABAA68692" modified="2018-06-20" version="1">MPRFFTGDALGAIKTVDYSQNGSKEWTSSTKVLFQGQEGKNKAIQKLALSAEDDSNTLLAAVRADGSTNVFTVNSELECEEQWQWKETRLRDGQKFVGAAYTSTGVYSCTSNGALRLTKLSREADGGLHSELAALPMRLAEWRLAPNQQTFAYAGDEVELSVWDTERAFSAGPQEAGSSKNNDSESKKRKRSEQLLSNEIWRAKNLPNDTLNLRQPVRNTAITYLQPSASTSQQHLLVGTQFGDVRRYDTRAARRPVENWKGVAKVGAVGVIEKGLSEHEIFVSDRGCNLFALDLRNGKVAYGYKGLAGAVTSIAPSPSFVASGADDRFLRLHSTFSLPSAVGEQQEQKGDVLDKLYMKVTPTAVVWDGKVSAAISESGEGSDEEADDDVWEEMEDVESDDGRTERKKSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM41</accession>
    <name>A0A2R6QM41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000324">
        <property type="protein sequence ID" value="PSS10991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM41"/>
    <dbReference type="OrthoDB" id="2658589at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS10991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1132" mass="128281" checksum="E864E4F07B3E9246" modified="2018-06-20" version="1" fragment="single">DTQGSAQRYTFVLPYSTGNTSRQQSSIFVSPNSPQIPLKPPKYATTADIYVPWHAYRIRWAFDPYFYLAFIPRVEDYSCPLFSCLQHSKFSLPIETVPDAPFVTYQLPPSVQEQWMYLETVIDTAFSALCKLSNFPFPLEHRAPRRPSEYGYTKTYEVRKKAHDAAMFAKASFALRLALVSFLVCVMRRTGDAYEDPWWAQSIVEEKLLPLEVVYDLVHSWVCNFSVPRKGAFVDITLTGKFDDAQPSASTQWFSFIPKILDLGACVPLWFYYGEDVRQFYINDVARTYRPAEDEVKAALERQPDMQLSSRRYGDVRMRGAGVGQEVHEATTPPPRIDSQLQGGQASEQYSEGGMEEDLAAGATETRSPYQQRQQYKARPKDSHSWQSRRRYRDVGMRGTRVDQVVHEATTPPPKINSQLQGGQAPEQYLGGAMGENLAAGLTETRSPYQQRQEYEARPTEQPISYRKDPHGWQLVCNNGSPFQEIRVDNVRVIWNSNEPSQQRDIGYRNKYDNHGEKSSPGAEETFSAGYRDDDRSWHRNSRFETNKYPAPRRQTDFSDSSRYSSPQRTPSRCGRRSSRSASPLPRRKQDGSPRGRRRSPDPRRSPRVYHSRSRTPSARRRSPSRTPSTFRGRCLSSSPSRSISRSRSPRSATPDVERSRSPASSLVRSTVAGFEDDRPEMDVDFGIPPRSLSPCSVVLDFESACHAASSQETLAVAEFEDDGQGMDVDVDLVQPRPKEFNAVIAVDHQQAEHEQEQEQDKEDTVLAVDPFLTILQYRYGFVEPSPQCYVSHPSFTKIALPTDFIPHVMSFNLCNETIPEQTLLAVRDFISRLATTQIPPVELCDLIPGNTTGLPRLLGAPMTASVVQGPPTADCQWYSIHSTTIPDGCDVSWTLVVEDPTTVSEVLRRGWGPSKLDVARGLLQRGIPFRTLLPVDQHVPKPSVPQLNIQLGHHPYDYQPTPGDYTNYEGQRDTLLGRERVCRAALMKGGIVWRLAMEMFGVESVLFGPKDVEAALYRAVLHDGGSYVDDDLTQDELDVVCGVYKVTTKNNLNAHSASSWWPKSSTWLDSGFDFGYWTPQNELWFCRRRREIRAGQAKLKTTKEWKAQLKGEKVLSRQLISKIRELSSRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUJ7</accession>
    <name>A0A2R6QUJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000311">
        <property type="protein sequence ID" value="PSS15409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUJ7"/>
    <dbReference type="STRING" id="98765.A0A2R6QUJ7"/>
    <dbReference type="OrthoDB" id="3241983at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS15409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="229" mass="26198" checksum="A6F2342CF2C7F6E8" modified="2018-06-20" version="1">MTGYLAFPPPRSSLPHETRTPLSSVQEQAASIGGAQTEKDVLKKSKEEAQAKQREIDEERRIRNLEREQREVYVSELAWVRSGGILRDANGRRDKVRTEKMRKEIRILDEEKRILDCWNAYESRWHALLASNDSICWKDIPWPVCNAPSSVADLAPELLSAFLFAPFKVRGQAGSRKERIRSSILRWHPDKISIILARVVDEERDLILQGVNTVVMSLRALQDAEKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0X0</accession>
    <name>A0A2R6R0X0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000287">
        <property type="protein sequence ID" value="PSS18890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0X0"/>
    <dbReference type="OrthoDB" id="5083627at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="556" mass="62110" checksum="9D76C6AAD6CE7BC5" modified="2018-06-20" version="1">MSTDLASYLKGMHSQSVTCNWDVAVTYDEAKINALLAARYAQPSSGMTTQIDIQEKVEDRLGEYYQNYQFKLGPPLIQFQSPSSDPTCSLKTQIVSGSSIWTSKIDEPWMKEDEQQLDPNKYWITIYRIRLSVLDGHAEHVGDGDDTITFPPNDESDRYVVVDIPNTGEELFVFIDYPVGYLPPYAMRQNFLQTALKEFLQKQTRAFAYTLASINNYKPPSGTLDLVPQAFRFVTYNVSKDLSFLTLLVQTRGSSNPGDTKDVQSEWVTTWSYSAKVPPVPSTQSASIIINNSFFLQSFVKPALRSQTTSMTDIAINGDIGGIGLQCKWPKQTREKKDYYKGHGDITSWPLDWEWSELHVPAVEYDPNNGSPLMLTFSHSNGFDKPATLHIHWQYGYKSTWNGVQIKRFWLNDSDGPGQWVPDAKKCDGSFNTAYTLDKTISLTDLSDEDLSINVDARSDEWRTDAVPDAGNGFWGDISAVFGGTAHQGDIPSFVQDTTMGGIGFKLSFGALRFFSVTNILLPGQKVIDVNIKNGLCIPRDCAILGNVVEPANIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3Z8</accession>
    <name>A0A2R6R3Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3Z8"/>
    <dbReference type="STRING" id="98765.A0A2R6R3Z8"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS19956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29789" checksum="9341F0987F52DB77" modified="2018-06-20" version="1">MQQIQYNPLRRLYSTKGSSSKSQAPSSKQPSRPQYASREEMYRARNRSLLMYTSAVIIMGLGVTYASVPLYRMFCAATGFAGTPKVGMGKFEADRLVPIENAKRIKVHFNADTSDALPWSFTPQQKFVSVLPGETSLAFYKAKNTSDKDIIGIATYNVTPDRIAPYFSKVECFCFEEQKLLAGEEVDMPLLFFIDRDVLDDPTCRNLDDVVLSYTFFRARRNSYGHLEPDAPENIVQASQGFDKYEMSPRAEDRKKAETSTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7F7</accession>
    <name>A0A2R6R7F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000266">
        <property type="protein sequence ID" value="PSS23495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7F7"/>
    <dbReference type="STRING" id="98765.A0A2R6R7F7"/>
    <dbReference type="OrthoDB" id="3194625at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS23495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="303" mass="32752" checksum="3BFD7F57E45221CA" modified="2018-06-20" version="1">MSASTRRAIITGSAIGGTVFFVILLVLFLFCKRSSKLRLNYKKLRVFGNRRRRTMLLDEDDDFDLGDPGMQRYTDNPAGRPSSYPTSLSSSRSHGQVFTVPGAGPGPVPSPHLLGLRASESGSIFREAVWPPPGEGSRFVDPIVAGSSEVDLGRIVRDVMGPNILTSSTHPMNPILNSSQVTIQPSVAIASGVGMHSRATSSTRLLPSPPFQSPTHSFPEEPPSYDTDDEHREMELGRAQSPDSQVYSMRSAPLRITNAGPESPLSPPNAFANVSGSPNKNWLGRAPKSVQERDEEVVMGEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHT4</accession>
    <name>A0A2R6RHT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Growth hormone-inducible transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHT4"/>
    <dbReference type="STRING" id="98765.A0A2R6RHT4"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS29571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="19996" checksum="AB6A5A525CCF34F2" modified="2018-06-20" version="1">MAANPWVVLGVSLVGAIGTMMGVMMTPPENTILKHAFWLGFNACQAATLSPLFFFSPAILSRAALYTCGVVGSLSYVGATAKNDTYLYWGGPLLAGVTVVALSSLAPMALPLGVRSLAVTQAISLYGGLAVFSGFVLYDTQKILHNARLVERGLLARDPMKESIGLELDMINIFIRLVQILSMQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI37</accession>
    <name>A0A2R6RI37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI37"/>
    <dbReference type="STRING" id="98765.A0A2R6RI37"/>
    <dbReference type="OrthoDB" id="3268205at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="244" mass="26455" checksum="05809B6D7886A886" modified="2018-06-20" version="1">MSHPNTQLQSSTIDILQSLVARGDVDLAALLSAESIVVDKLYSCIHLGSLDLQNKLLHLLHSIISAFRARTDTSNNGQQKLDDQRGTESTVNINSLLVQTLVDGLSVSSNRPILQHWLDFILTTIPQFHEILQPAIGPLNDCVCRLLQSGLEEITQASSQSSTAGDISVIATDADFLMLLNALERLVLLSLSQLPDTTQVDDDVLSEKPTTEGTSILGYVSNVFSTEPTSGLTEEQMPVSSVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIN7</accession>
    <name>A0A2R6RIN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000248">
        <property type="protein sequence ID" value="PSS29874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIN7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="124" mass="13938" checksum="ACAB871F5BFC55D5" modified="2018-06-20" version="1" fragment="single">IGVESVSSRQTKKIRDTEHVICWFESRTSYKISKPPNLPSKLGLEAEDLYIHGHAQGRYQAWRCTGLGPPKWIPLPQGTKRKLPGLKEPRHFVLTAKGLPSWVLSSSLDRAYKGVKTEALRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLQ9</accession>
    <name>A0A2R6RLQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="9">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v2489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="9"/>
    <dbReference type="EMBL" id="MLYV02000230">
        <property type="protein sequence ID" value="PSS30964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLQ9"/>
    <dbReference type="STRING" id="98765.A0A2R6RLQ9"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS30964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="663" mass="72803" checksum="5D6476477794FD72" modified="2018-06-20" version="1">MSSTTATSAPNFSGQIALGASVPAFTAHAISVSLPTWDDVVGYEEGDKRVLDVMVTGYPRFFIHLSIRKLARICEQKFGVNNEQAMLFPTRKIAQACRSFMVDHSCQPGPPVPVRLVQFFISPEDASASTATGVELHIALFSAEAFPLAKQFWQHSGLGISSRLAEYCLSMLPDDTEAPSPTTTSTRVPAKRTGSNRHYSAKSSLSSPPCSSPLSVPEPPAAEVLSADQAVYLEERYGRNLPLESAANAKRALRRRIAGVLVRDSPSDWSEAGGHEAELGPSTRGVKEVTEDDVYLFPTGMTAIWNAHQLALGVMPLAKSICFGFPYTDTLKILQKWGPGYHFYGHGLDKDIDDLEILLAKEVSSHPDQPPVLALFTEFPSNPLLRCADLSRLRGLADKHNFLIVVDETIGNFVNVEVLPYADIVVSSLSKVFSGDCNAMGGSLVLNPKGRYYTALKQYLVKNFEDSFFFEDAIYMERNSRDFRRRIPVIDGNTQAVCALLHSHPETVKEVYYPTYTTPEHYNKCRTPAGGFGGLFSATFHTIEASKAFFDALPFHKGPSLGTNFTLACPYTILGHYLELDWAAGYGVEAGLVRVSVGMEEREALLEGFANALKAAEMIPSDDDNSQLRTLGAEIVYRRVVTDPSRSKLKEPESESLVQVLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPK8</accession>
    <name>A0A2R6RPK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v2289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000212">
        <property type="protein sequence ID" value="PSS31962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPK8"/>
    <dbReference type="STRING" id="98765.A0A2R6RPK8"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="13">
        <location>
            <begin position="417"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS31962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="833" mass="93211" checksum="BE05F5A56084D12A" modified="2018-06-20" version="1">MDLIESSLFTPPILILQTVLEEVRHRSLPLYNRLKGLVKADDKRTWVFYNEFRSQTAVVREEDESPNDRNDRSIRKATSWYNTHLSLARPPIQGQPRIALPAVVLLTDDAANRQKAAQDGIKCMSVRKYVEGAKENSKLLDLLSVAGTDDIEPTKVTAARQALYPEYLPTATIMAGVKAGQLHQGHFNANQYNYLEGSVPVAGLDKPVLLIGRENMNRAVQGDVVAVEIFPESEWKAPTDEVIDQEATLKNDDADDTDEEVDDQEDVAERKVGNAKRVSAERQPTGRIVGIIKRNWRSTSLTSSNTTSLSQQTVFATPVSRLLPRIRLRTRQAPSLIGQKILVTIDRWDSTSRYPEGHFVRSLGKVESKEAEQESLLLEFDVPYRPFGKAILNCLPSEGDKWVVPPKKDDNPEWRDREDLRDLLICSIDPPNCQDIDDALHARPLPNGNIEAGEMTSDAQIVNVRFTKSVIASKEAFTYEEAQIRKDDPKLNDDLTKSIRLLNSLAIKLRAGRMAAGALNLASPEVKIHLDSSESSDPIDVEQKELRETNSLVEEFMLLANISVAQKIQETFPQTAVLRRHLPPPRTNFEKLQDILKKRKGLTLDVSSSGALAASLDKCLDPSEPAFNTLVRIMATRCMLSAEYFCSGSVGRDTFGHYGLASPIYTHFTSPIRRYADVLAHRQLAAAISYTTLHPSLHSKSHMERVLDVVNRRHRMAQMASRASVEFYVGLALKARGSRQVVEEDAFVIRTFRNGVGVFVSKLGIEGLVTFKRETQFDADNYVITVPSSESRGQTTIAVFDKVRVQIEVEKDRNTQRGKVKMTLIHPVNSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPS5</accession>
    <name>A0A2R6RPS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhamnose mutarotase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000203">
        <property type="protein sequence ID" value="PSS32028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPS5"/>
    <dbReference type="STRING" id="98765.A0A2R6RPS5"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13003" checksum="631027A37E093580" modified="2018-06-20" version="1">MAVPHTKRVCQIIKLKPEAEAEYLEIHKAAWPGVLAALSRHNIADYSIHYYRPLHLLIANFKYVGHEYEKDMTGIAADPETRNWWKMTDGMQESFEEGATGSGGDVSWWTVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVH2</accession>
    <name>A0A2R6RVH2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVH2"/>
    <dbReference type="STRING" id="98765.A0A2R6RVH2"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS34029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="813" mass="90027" checksum="92F17143DCDA6CC2" modified="2018-06-20" version="1">MKFSSSLKFNAVAEWWDEYIAYDTLKKYVYQLEKQQAGLHEAIHDLEANEGTSLIQDRDIASKDALFIPLLDRELKKMCSFYELQETNLLREVNDLEKLVQQQEEYGPDIGHQYLDHVDEEDDDDDDDDDDFAQRSPAASWSRSPLSRRKRSLSESTGLRGASGSNWRSEPSNRRYSISSNEDHVDLEASIVSLRSANGEPSGAHLSPPPAQERGNSVGRSPIRAARTLANKIFMKDSVTSSMSAPETVWTAKTNYARDIQLLFKRRITNLYLSATSLRSYVELNYSGFRKILKKYDKVLESNLKDHYLHDVVEQASPFTMSYKDKLNHTCDHLVEMYARCVTHGDFPTAKRQLKLNQREHIAWERDTVWRQMIGQARRGDGNSGNARAQGGTLVGEPEKGLLDLDTPAGHFKLTTKHLFVLVSVIIFAVLLNVKTVDGEEANRCFAILVFATLLWATEAIPLFVTSMLIPLLLVCLRVIRSSANQDGETERLGAVGATNNVAAPTLCFTLIKLGIALAANIGGQSSPISSPQNLIAYDYMDSPLDWAKWFAVALPVSALSIFLIWLLLLVSYKPARSPDGEGDIEIKPIRPSRDPFTLQQYWVCFICLVTIILWCVEHEIADFVGDMGIIAIIPIVAFFSTGVLHKEDFDQFLWTVVFLAMGGIALGKGVTSSGLIEVMDEAIRTIIGDMSLYAVVIVLCCIVLVVSTFISHTIASVLLVPIAKTVGSRMPGQPENLLIFITALACSTGMGMPVSGFPNQTAATQEDDMGQLYLSNVDFLKNGGGHSGLPVDDCNVSLSPLTVLLPSDNGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZA2</accession>
    <name>A0A2R6RZA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000137">
        <property type="protein sequence ID" value="PSS35355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZA2"/>
    <dbReference type="STRING" id="98765.A0A2R6RZA2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS35355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="34583" checksum="88864380977622BE" modified="2018-06-20" version="1">MARSKKNEDHIPRPPNAFMLYRSDKNRELNVLKQSGAVLLFGSGSDNQVNRSQYIGKLWNNEGDDIREVYHRKAVVAAEEHRRRYPHYKYRPVRKTRTPNKPAGHNESIKDETFPLQLGIPDGSQESHNSLESWDSGLTSDLPAHALHVLRDYDSHSYGSSSSPPQDHSKSYDPTQNSQDGSNRTDESLYPAYALQQHTSQIPLLQSYEKHGTQSNLGPGRVWEQDTLDVQDGRIGGRDAIPTYPSVLHPYSQVYSPNTGNLESRTASMAPYAPSLAREDSCGDIEDLEFTPRLRGSQNEVPSVLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZM3</accession>
    <name>A0A2R6RZM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZM3"/>
    <dbReference type="STRING" id="98765.A0A2R6RZM3"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015347542" description="DUF1793-domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="105"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="404"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="562"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS35457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="71536" checksum="3EB6D4341B1D35D7" modified="2018-06-20" version="1">MIIKLIGLLTLSALHVVAAVTWSATPFNPASVPLAVRSPYLSAWLDQGAGTALNANWPHFWTGSILGWAGYVKVDGTTYNFLGAPSVPATTVQKAVQKSLTFTSTQSTFVMTAGPVDLTVNFLSPVEPTDLVKQSLPFSYFVLSAAPNDGKSHSVQVYSDISAEWVSGDDSLTVNWTTTTGSVVTHQVQLEQQTLFGEVSDRIQQGSAFYSTPSVTGLTYQTGQDEVVRAQFINSGKLLNTQDTQFRAVSDDWPVFALSHDLGTISTATPPVVISIGHVRDPAVQYIIANGALQNRSLYFWSQFSSVQDAISSFLGDYSNALSRAQTFDSKVQTDASAISADYASIVALSVRQAFGATEITVSKTTSGSFDTSDIMMFMKGKYLLLPLFEYQATGQYPNKWSFNLLDQWTQFLISDSLIPANQISTDDFAGSLANQTNLAIKGIVGIKAMSVIASLAGQAAKSSNYSSISASYVTQWQKFATSSTGKHLTLSVNIPRKLLDTLILINFTMNGNSTEMIPGMSLVQSGHCDNAYFPSWGLSYNMFADKLLGTNVFPQSVYDMHWEIWTSAIVSSNTVRDLFITAVRNYAADGKSSQPLGDWYETADGSVEGFRARPVVGGHLALLALQTQPSATTEPNVSAANVTAPTIAGPSSNSAPGMRRWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S019</accession>
    <name>A0A2R6S019_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000111">
        <property type="protein sequence ID" value="PSS35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S019"/>
    <dbReference type="STRING" id="98765.A0A2R6S019"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="34"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="333" mass="38262" checksum="9C74AB28A1A397CF" modified="2018-06-20" version="1">MASPTSVSSEEIRASSYVGFDSITSQIEHKLLKRGFQFNVIVVGQTGLGKSTMINTIFASHLIDSKGRLAADEPVRQTTEIHPVSHIIVENGVRLRLNIVDTPGYGDQINNEGCWDPIIKYIKDQHSAYLRKELTAMRDRHIQDTRIHCCLYFINPTGHSLRAVDIIVMKKLSEVVNVVPVIAKADSLTFEERESFKEKIRGEMIYHNIRLYPFDTEENDDEEIQLNESIRVRKLYCRPNTNFNRMTQNMIPFAVVGSERSVIIDGKSVRGRKTRWGVVNVEDEKHCEFVYLRNFLTRTHLQDLIETTAQIHYEAFRSKQLLALKEQTNRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3P1</accession>
    <name>A0A2R6S3P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3P1"/>
    <dbReference type="STRING" id="98765.A0A2R6S3P1"/>
    <dbReference type="OrthoDB" id="3253876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="330" mass="35760" checksum="3D5346DEDD322800" modified="2018-06-20" version="1">MYSSRQSYGSHPPELSNNPFIDHPSNALTRYPDINGTDNPEGTSTQFTSWLQASGQSAATSPGGYFGPGQQLGSNAGYQPQQQTGWPGNTGYPQQPGYNTGYSSPVQTQPSGMPFQPSSSFGQQLAGHLNSQYGTPAPQQQASYTSYPTSPQQATPYGYPPQQQQQQQSQQNAYVPEFDPYTSQGAVAPQTASQFKPQHPREFIQQHKAELESWDAYAWKQAINSFDSLKDAWNARKQEIEGRARSMGGSGLFGSNGYGGGYGGGYGGQGQDIVRLEQGASVDTAAAASFQMQEVYTGYRQSGDLASKRRVRESINAALSSLPDWPPQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3W8</accession>
    <name>A0A2R6S3W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v1178</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3W8"/>
    <dbReference type="STRING" id="98765.A0A2R6S3W8"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09901">
        <property type="entry name" value="H3TH_FEN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="11">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS36962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="725" mass="79650" checksum="3DAC8A6E53DA6D41" modified="2018-06-20" version="1">MGISGLLPLLKPIQVDKHLSEYSGQTIAVDAYVWLHRGVYACATELATGKRTNKYVDYAMHRVRLLRHHNITPYIVFDGGPLPAKKGTESDRKKKREENLARANALAAQGKHTQARDFYVKCADVTPQMAFQFIKALRAEAVSYVVAPYEADAQMAYMERIGLVQGIMTEDSDLLVFGCRNVLLKLDAVESTVTSISRDDFASFASPAGISFLGWSDVQFRAMAILSGCDYLPSIPGIGLRTAYALLKKHRTAENVIRTLQAEGKKVVPKGYLQAFKLAEKVFLHQRVYDPTLQVLVNLTEIPGGESWDEENEAHVGGYIEPVLAKEVAEGDVCPITLLPMEDINPTFVPRALKPIPMNSMNLPRSDARKGKGKMILPEKAKSTSLLTFFSPKSKMETPPKSSSRPTPPHIGSRAKICVPIAGRSSGKRTLADLMEEDMSAKRKKHNDKKRPTDRTLTTATSKFFSGTSLSIAKDKPVRNVSLDIAGPSRLQHFSKGKENICSFDEDDVDEISMDEDPDPVSQEEGYISPSSSSFRWESPELSSPLRPGSSSFRLAVGAVDDDFEADILSSPLAAGTRRQQSRRPQSCVTGRVLVHGTPQRSRVKDEGAPGPDLRDIFEDWNDLTSEIDECCEDSMESLESSSGPVTPVSSSQPAGQCVDDIFDEVTPDDEEIEQQAVAARNESVASGWWQKWSCGNATPLQPPSSNLRIKSIGFASSGYLHGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S435</accession>
    <name>A0A2R6S435_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S435"/>
    <dbReference type="STRING" id="98765.A0A2R6S435"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF5">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="108"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="749" mass="84316" checksum="513F952D136BE6A4" modified="2018-06-20" version="1">MVSRKTSRVLTRYPGWQAIEGDIVGCGVDFDDHIIFFTKNGVLMGKYRPLNVVSLHCLNIHTGVATFDIFDIRSVETLIPAVELTLPTSLVSFNFGCHPFRWNPPGKSDRIDCSAIPRSFFNEYDAFFVAATFWIRANEGIEISCDGRVLKKSRLTTTSNSVTARATSDIHMNGQGISYYEVEVLQVHRDGLITIGFEVQPRLPTTSAGSYLGHAVGAVEDSGGYNSDGVVSRGKSLSDQYGPKFHSSDIIGCGMVPVSSPDHMASVFYTLNGSFLGTFFDLANTALNVVFPFVSLCDPDDTVRANFGQEPFRYPIGRIVRDFTCETQWPRLSKPRTLPSEVIGVILAALVPNDLDHSYNKKHIAWCALVCRHWYRKCSPYLFKTIKLHSKGDMNILYARIEKPGSHIPGASITSLTLNEGDGDVWAYNVALSMANKLPRLHKLHQARENASDWKVIRSRIPPRISTSLPALYSAYTMVTTFILENHRFRSFAAFTQLISALPVLETLKCKYVTWEERPNNPRLLRAPRRLSTIEIALASRQSGQMFQLFTARWGAWKPTSKYPELGCNDSKLIHGMVNIDDPNIPDPFGVASKIRFATFADKGRLTFVWPWKSTWDLTFSSCGIQDGPSRTCLTNLRIITYRGFLVKSHLHYTWCPWANWLNKTFSEAPPPFLENVTIVSEEKTTFIKQAIEASKLRSCLPHLQQAGKLRFVWKQYIDDEGTKEWEITEEDERAAVESGYGGSIMTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S462</accession>
    <name>A0A2R6S462_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S462"/>
    <dbReference type="STRING" id="98765.A0A2R6S462"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="499"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="790"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="838" mass="94331" checksum="B9B5E23C04E33961" modified="2018-06-20" version="1">MDQPSKHSELSSNSFNEYNAELQAAALKATRNAAYLPSDLAFYRSLDRHFAKEVDTSSARVLSLANRILDLVSTGDVVTQAASRSKGKGRLADEDDVIDNFRPLVVDAMDQLLERADICLDQILGLSKAPGIVVNPQPVKPKAPKSNVVSKGRLDPALQHASHLAKPQLKFKHRVDNRESTVWRPSLKHKYNAQVPLGFDLRQEDEDMSFDTPLHPYRHEIRNISYPSYMFRYAEPIPPKSFTDTPFAWVSSPEEFASMLEKLRGAPEIAIDLEYHSYRSYTGFVCLMQISTREGDWIVDTLSLREELEALNEVFTDPNVVKVLHGAESDIIWLQQDFNLYVVNMFDTYHASRILEFPKHGLATLMEMYCDFIPDKRYQLADWRIRPLPEEMLQYARSDTHFLLFIYDNLRNALLDRAQSRAQSRSQSPSALAGASTSNPSNSYPYQAFVLEVLSRSAETALRVCDRERYDADSGSGPGGWDTLARKWNKGALMASERDNMKRRVYKAVHAWRDRIAREEDESTRYVLSTHYLFMIAEQPPTDLAGLLSLFHPVPPVLRRRSKELLDSILAAAKEVDSVPDDLHKAIPEKMDVDDVLETTSLEITATAPGIEERLWPSPTKATIAATSSSLFGATLKTVSHKSGPVAYLATQSSLFPTGNRSQSKSDQNRRFSELVARIHSSLVIAPSAPQLPRPAADNTSVTMEVDMEEVVLVDGQVEIPFVPASQRQESNRVVVDDPITDSIVVVGHTQRKKRRRAVKSEASAVVTEGDQPNPSTVEAFDYSTVSNILDEGSDHEPEEKIRRKKQRGQGRFDYGNFRAPPKEHREVKSGNQSRTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4T8</accession>
    <name>A0A2R6S4T8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4T8"/>
    <dbReference type="STRING" id="98765.A0A2R6S4T8"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015356383" evidence="2">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="188" mass="20735" checksum="E7173B16D420C614" modified="2018-06-20" version="1">MHCFKIVSLLLLLVLSLGLAPTLVTAVDLRAYHNSLEARYTRAHSLGNNYQFDSRDGWQTVNASNLQYKYSREPEDESDLEGLDGPDDSSAGLTRRDNKTKATSKSKSTTKAKSTSKAKSKSKKTSSKTKATGSLSSSLKKIIDTIKGKGKAEPVTITWYTGHDLENPSCWPQPTWAPTVRTIQRAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S556</accession>
    <name>A0A2R6S556_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000044">
        <property type="protein sequence ID" value="PSS37406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S556"/>
    <dbReference type="STRING" id="98765.A0A2R6S556"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015315764" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="111" mass="12027" checksum="2395FB4B2AD66A21" modified="2018-06-20" version="1">MVFVALALSLLLATSTVLGSPIARLHDPFPPTPKTPKGLLCNLPIPMVQKLLCPRQIANSDPTVNTPLGTAHGVDDTANAVRFAVRYGTAARWEPSSIVTSWQFPYVRFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S574</accession>
    <name>A0A2R6S574_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000045">
        <property type="protein sequence ID" value="PSS37403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S574"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="18457" checksum="4113E504CE4719F2" modified="2018-06-20" version="1">MYPTEEDFGLDHPISTILPDYPALYDDYEYDDYILLPLTLPGVLIPSPGLPEEPYGLYSEVRRHHAYLWPSYPDVAQDLLSPPPHYDFDVSEFDDDDDEPLLSTQAIPNWFGVQSKGILAFIFGCISLTVVAGFQSRGITRHFDVWLKKLKDTFRKLVRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5E0</accession>
    <name>A0A2R6S5E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5E0"/>
    <dbReference type="STRING" id="98765.A0A2R6S5E0"/>
    <dbReference type="OrthoDB" id="3365917at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="315" mass="31913" checksum="1F571661F48509EC" modified="2018-06-20" version="1">MFVPILTPLGQRLQRRKGGGGKGGGKGGGSSGGDGSSGSSSSSGGKGGSSSSSSGSKGPSVPVSGSTGGKSRTSSAYGSGGGPVSTIPSGQLFQGRTEGGATRNQVYGTRTYGSGYPGTASRGVSGLGFPFIFWPVVWGGTLGYGASYLHDSREYGDVNNSSRPGGPMTQTTFADKNSNNTFHLLSDNATVLSLIGSVAANCTLGNTTALTATPLNTSDPSQPRAEQAVQYYRASSVVLTLDGYNDTAALSDNSSIPDTPLPTWVDSSFLNCLNQTIGAAVPLIDAASPLASLHWNSPSMGLLGLIWTLIFYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5E9</accession>
    <name>A0A2R6S5E9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5E9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="82" mass="8837" checksum="9AEA1E7AA60B494C" modified="2018-06-20" version="1">MHYPHGETYDLLPIASPHASNSGEGRRFIGIVCPGADLYAVPETSTCSIGVSGSSSPVDRAGKPTRHHSRGREMIEVRPIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6L4</accession>
    <name>A0A2R6S6L4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000018">
        <property type="protein sequence ID" value="PSS37924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6L4"/>
    <dbReference type="OrthoDB" id="2730545at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="255" mass="29322" checksum="5DD55BF020430693" modified="2018-06-20" version="1">MQTDRMRPVRTITDAGIPCLVWGEDALALAHCVPTVFFDLQVIVPDDQVEAATLAILDAHPYYQRSSTPSPHWLEYKLIDPAEPYCFVNSTTLRLVSPPGHVPRDDDPTTILIHPQSHFYLDVRDHRRSLSLSPPLPLPYANIRFPTIAAMLDAYIAAYLDLPLGYYHYRYSHRVRTCISYLCLYSPVMRAYPRILPNGDLEPGHASVRESLSPENRQYFELYNRHTLGGSWIDMVKDQRDIMEKMGRVTYIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6T1</accession>
    <name>A0A2R6S6T1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6T1"/>
    <dbReference type="STRING" id="98765.A0A2R6S6T1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015316735" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="53"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="27529" checksum="15A151FC2B41E958" modified="2018-06-20" version="1">MGENFVLMLLLVASLVQILVAAPTYNPRQLSLPSQLNPYPTKPRLSFRPDGTFKITVFSDLHFGENAWDVWGPQQDVNSTRLMRKVLADEKPDYVFINGDLITGENTFRENSTVYIDEIVAPLNDVKVPFSSTHGNHDNQANITHLEEILREQRDAPLSYTRVAPPGVGGEYGPGNYWVPVNFQPALIIWAFDSRGGWSEGQGSAPLPDWVDDSVATWIEQETALMDSVWGPPDKTRGALAFVHIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S723</accession>
    <name>A0A2R6S723_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v84</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S723"/>
    <dbReference type="STRING" id="98765.A0A2R6S723"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS38104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="257" mass="29197" checksum="1387B1FC779D10C2" modified="2018-06-20" version="1">MVIKAGLFSAVVTAFIIESYKWLQQDNSQAAVDVLSRISTQLGGLTINQVFVNSTEPPLASLPPFIPSPVMVSINVLWFLSLVLNLSAALLGMLAKQWLREYLKWDSVLSPPQENVRLRQLRFQAWNDWGITTKISAIPALLEIALVLFFAGIITFLWTLHQTLAIIVSLTISIFLLIAFIVTIFPAFSHSCPYKSPSGWAVTVLYDRVLRGVKFAVYIIRTLKVHDRLSWPDYKLNWSNYYGKLESWRKRDLHLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S792</accession>
    <name>A0A2R6S792_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v30</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S792"/>
    <dbReference type="STRING" id="98765.A0A2R6S792"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15396" checksum="D7BB2A8FA68F5C5D" modified="2018-06-20" version="1">MTCGPYRPISLVVYQTRLSCVNTRASVSNAPHLKPNLKVDIDISGAIDESDAIRCVLRKSGNEGIIRDETIQVPFTDRDEDSSKLTLEGLFDWNLDGEVSMWWPIGYGQQDLYDVEITLLSKVSTSDSKILAAYLNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U7K371</accession>
    <name>A0A1U7K371_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000384">
        <property type="protein sequence ID" value="PSS03524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U7K371"/>
    <dbReference type="STRING" id="98765.A0A1U7K371"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9892" checksum="711FF54F0C0D0B29" modified="2017-05-10" version="1">MQEIFEQRTKQKKNALAKLRHHERINEGKWRSPKVPRLLLPFWEIARYARLLSRKLSKKAKRLVDQSAAMWCLFEDRGADSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U7KFZ4</accession>
    <name>A0A1U7KFZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000954">
        <property type="protein sequence ID" value="PSR74856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U7KFZ4"/>
    <dbReference type="OrthoDB" id="3254002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8610" checksum="B3FB36B423B407D2" modified="2017-05-10" version="1">MSNGQGLPANPLDNQIQLQTYNGVISPDVYRRNMEALRAAQETLAQFERQTLGGYNRFITAEQELRNRVEAGRQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEF2</accession>
    <name>A0A2R6NEF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEF2"/>
    <dbReference type="OrthoDB" id="3184970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26917" checksum="92E7B5817A0FF4AA" modified="2018-06-20" version="1">MSGQPEVQDSVTHIPPFNLPDADLVIRSIDNVDFRVHRTTFVMAGGEDLLARSVQDMEEITLDGTPVVRMDAIQDVVTELLRVCYSLDIAHPVFQSGNVHMFRRVVETATTHGLTAVVLAARSFWKTSLPNDPLSMYLVAANLNWDEETKAALQYLSSLQPPAFVHSLIYTAELEQVSASVYHELLKQRHQYQATRRNDQLSHIMVSNGGYQVTIIEMVGKYIEEYLSLEKSVRQRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NET7</accession>
    <name>A0A2R6NET7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v13235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001305">
        <property type="protein sequence ID" value="PSR70873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NET7"/>
    <dbReference type="STRING" id="98765.A0A2R6NET7"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="286"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR70873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="590" mass="68713" checksum="E45A0C36E0FE8143" modified="2018-06-20" version="1">MDSGMILDARDEVPFEPLLLLLPEELCWMLDRNFACEMEWHSGNTLSQTVFTFLYIHQLADINPDLIPPGFPLLKDPKRPIELVTLVLRAAVFGLLKSCDFVWRELSKKRVFDMEDWQSDKCEVTLLEGVPVDIVLRKLDDACSWLRNSALPQTDKEALCDRLMLRKTLLELFKLSHLDNLDELRPLVAIAKNILRRVQARPSVQPIDGSPALYSFDPRVVRRLHTVMPIRVLELPSQETVWSKVEQLLEGWEQVGHLRSVHSLSGWEIAGSLSVWMSERKLQLPYCRSLTQGTFSDRNLVFGEYPTEWLVDHFFEESLGVSYETIRDVLEDDIERWALKEIEDHIIRVTTNYIKSFWYNPPRHRRFLMRAILDWQLLQDALSNFSSQVLVIDFESYMISFCLPRAAALWKYTAAREILLSGFHQELYSVHERPLAYWYTAHIIEQHIDCIDGMRRVIPSDSVAFIEMQFQSQFLGALQLVCAAMCMITSNALTQPRKRTALNFRRRYKWLFRPESNSELLFPVPLFSDLPEYLDMVTDDEPNENLKLAIDILQDLKQFDCRGVWATEEAKERLAEKQAMPKGALGYHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF83</accession>
    <name>A0A2R6NF83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001296">
        <property type="protein sequence ID" value="PSR71047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF83"/>
    <dbReference type="OrthoDB" id="3248709at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="179" mass="19698" checksum="2560042896C2E6D6" modified="2018-06-20" version="1">MSDFLKPRRNEAVARIRTNGMGLVAVLIITNLLPLPSPWTAFRVIWEGTSGYGGMGVPSWWWALCISGTAFTLIHHLMESYICRVFSPTRLLIELAVMSVLAFNFLQASYALKYPPAPLPPPSTPAKPKAVPVTPQANSVSQRKSTASKIVRIVYICLNSNINTFSNATLLDALFVHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF88</accession>
    <name>A0A2R6NF88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001296">
        <property type="protein sequence ID" value="PSR71033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF88"/>
    <dbReference type="STRING" id="98765.A0A2R6NF88"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="130"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="386" mass="43553" checksum="8A7D680FD8912610" modified="2018-06-20" version="1">MQTEKNRKYNNLSPEIWILNRNGLQRCDGGKPVCGQCVRYNRRDDCEFNDGPSPSNSRVLEQNIARLQARIHELEQDDPTLIRLQAPYVEAASPALHDQTNWWETPELPTNIVKTLLDSFVPHGFKFGFFLDMPRFLVSLSSTDNATPKIPDVLRNTVYLLGIHFSKSGAFMAHESVFLDKTLRCVHYALSVAQEQQTTTLYVLQAEILLAYYFYHNNRLVEGKFHASAAVSLAMLCKLHKTHSYGNIGVLPITSAWLSPSNDAVEADERTRGWWQTYVLDKSWAVALVESSSIIEENDDPATVVDTPWPEINNNVSISQRLLVTRLMLILLPQTATVRASGGRTLQVFFEGTSGDTNISTFGLHAQAVALYERASKLSSYQDRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFI8</accession>
    <name>A0A2R6NFI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v12991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFI8"/>
    <dbReference type="STRING" id="98765.A0A2R6NFI8"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="109"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR71145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="213" mass="21817" checksum="7C74707CD67B320D" modified="2018-06-20" version="1">MLPSSPHVRQVYTDASGILSALQSLSEEEVAQTFCIDSTTLDVQVARDVAKEVCNVRATMIDAPVSGGVAGAKAGTLSFLVGGTNDAFHRASPILAHMGKKIIHCGPSGAGLAAKICNNLVLGVQQIVVGEAMLLGQKLGLEPAILAGVINSSTGACWASSVNNPVAGALPDKEPPCTRNYEGGFATSLMLKVSKPASGRLFADMISGHGTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFZ9</accession>
    <name>A0A2R6NFZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFZ9"/>
    <dbReference type="OrthoDB" id="2794889at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40164" checksum="6A47229DB28554CB" modified="2018-06-20" version="1">MELFMRTVADVPSLTRFIKDVYAPISKSGKYSDMFGWIWGHPSSKVQRQELISLLSTSPSLEAITIRHLVPKNAVSVTPIDSIISSSATSNCIKRLTLHGSSFEARPHPQFCIMPILDVQLPNLEVLCLRGMYIMPTFQLPSLPRLHTLQLVENYYFPSGGPRPPLFTPESLPNLRVVEVFRNHFPGEAYGHLVSGSSFEKLECLHFLENKRCLEVTRWMSADSEIKHLAIGFLSAIDRVHLVCWRFPDALESLTLLLCDPSSCSPKLEPWTARRQGQVRDDGVEILQGVFRCLKLNKQSKAFKKLVLLAKFPGAEDVAVRLAREHAVRDIRILCASQEVEFSMSLDGTLPLVYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH91</accession>
    <name>A0A2R6NH91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001244">
        <property type="protein sequence ID" value="PSR71757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH91"/>
    <dbReference type="STRING" id="98765.A0A2R6NH91"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="16778" checksum="255A60C8891DE2DE" modified="2018-06-20" version="1">MPDEEAFCLLVRLMHSYDLRGHFLPEMPKLQLRMFQIGPEGADPKTAQYDIDLFVQDAVSMSVTPFMLDQYANEYEELVRTRDAHTIEVDGLRSSNRSLSNQIHNLEENLAQLNTEHVKVLNELVMARLRNEELESELVRYKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHY3</accession>
    <name>A0A2R6NHY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHY3"/>
    <dbReference type="STRING" id="98765.A0A2R6NHY3"/>
    <dbReference type="OrthoDB" id="3261666at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="382" mass="41536" checksum="45B15435B1E86702" modified="2018-06-20" version="1">MASNTIYQTPPLAGRPPFATDDDHIYGQQTQALTPRRRRSPSPDPNSRTSAYNVYDQYLEGSNRDSGVGALGMGMMNVDMDDDDDPFDDSHRPTPKQQPIPLAAPRPGYAAPVSALNLSRPSPAASPDGRQPSPSQMSQIPKPLMLVSSLNGPTSPRLPSPASMNVPSTPHPLPPTMTPITPAFVRPTKVGDDREVKFATTQPILRGEKEETLLPQRGEKGDDFWRRFSMVIKEENMRAPTEKTSPWLRETQSGATRLSRWIWVIGLGLLLCIAGGIGLGLWIARGDQSHNAPTAIGGSANEKLLSSSAANPVVTEGGVVTTSFHVSPTHTVARRVDFGEPLPTYTAVASMPTNFGSDTYVIRPVQPSRHRRVSQHLNRTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI33</accession>
    <name>A0A2R6NI33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI33"/>
    <dbReference type="STRING" id="98765.A0A2R6NI33"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="28209" checksum="E3D6F6E2AF6C0907" modified="2018-06-20" version="1">MDAEERIQAASKFLLQSPPGEINDVLNGDEAARVPGADSEEEDDRFWDPRSRTSFRFDHIALEASEPEPIEPEEEAEPFRIALEIAALTYLSAHFHGGVTSVFSTQGNPHRFTIQVVANKYNPSNFWSGRWRSEYIVNLQERKLEGKILLNVHYYEQGNVQLSTTHAVSIELPPTISSSNASASASKILAVIESEESKYQASLNEAYQDMGDKTFKGLRRALPMTRAKLDWDRVLGYKIGAELTANKGAFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI60</accession>
    <name>A0A2R6NI60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001229">
        <property type="protein sequence ID" value="PSR72013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI60"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6413" checksum="9742F495C68995D7" modified="2018-06-20" version="1">MIRTGRIEGNDDDGDTPQKLGSGPDSKSEIKELTELIRLSIILASQYRGPSSLVINEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI89</accession>
    <name>A0A2R6NI89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001216">
        <property type="protein sequence ID" value="PSR72096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI89"/>
    <dbReference type="STRING" id="98765.A0A2R6NI89"/>
    <dbReference type="OrthoDB" id="2418900at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="954" mass="108824" checksum="1906E6B8D6ADCC68" modified="2018-06-20" version="1" fragment="single">MPIIPQLAPNRCSFCHKRLATPIGVKLHIQNTDGCRRRWEAWVECKRSSKVAAHPSPPSLSNEDATPVNIDPPMDIDEFFAPLQYHPPGPSQKATVEDVPDDDDLARFVRYYPKPVALVLRRGENMFDEWRRTNEEEGRSRWAPFADEGEWELARWLLKNVGQNKIDEFLKLKTTRLPMRATVHRQIQRCDLSSGSKYTFFQKVDQLPEANPWIYDELTVTGDVLGEDGKLLTERLDLWRRDPVECIRELIGKPSLQDVMGYAPEQVFSDEEATNRIYDEMWTGDWWWEVQDKLPAGATVAPVILASDKTKLSQFRGDQTAWPVYLSIGNIAKATRRQVTAHATVLVGYIPVTKLQCFSDATRSLAGYRLFHHCMKNIVNPLVEAGKVGVEMTCADGWVRRVFPIVAAYVADFPEQCLVANVRESYCPRGLITPENRGEPSGCLLRSVSESLSILDKHQRGEDPPEFHERGMRPVYEPFWRDLPNCDIFACMTPDIMHQLHKGVFKDHLVSWCTKLIGDSEMDRRFMAIAEVPGLRHFKKGISHVSQWTNSERKEMQKVFVALLSGAVSAEVLKVVQAVIDFIYIAQFQQQTTQTLAALRTAYDTFHRHKGVFISLHVREHFNIPKVHAMFHYFEAIEKKGALDGYNTELAERLHIDFAKEGYRAGNHRDYIANMTKWLQRQEAANLREDYLDWLHQEEAAAAASLKKKVGSCVDGPEGDESDNEENTIDKRQDLRFLPSKNPRLYRIAIKCPSPRMALGVLEQAHGACEFLPALTAFLKLHFPQTTSSLPTRLTRYHIYKQLKVEQPWNRYVASSVSFDKIRATAAVPAHGRSRFVPQHLDTAIIIEDPSVYNAKLKGSLNGLRVGRVRVIFELPAEYGRLSHPLAYVEWFTPFGRVENNTRMLQVSRSTRNRKQNADVVTVDRILGACHLVGKTGLEIDRSWGSENVLETAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIR7</accession>
    <name>A0A2R6NIR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIR7"/>
    <dbReference type="STRING" id="98765.A0A2R6NIR7"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="644" mass="69544" checksum="0C5456DECAD9F7A1" modified="2018-06-20" version="1">MSSRYASSESDYAESRPDKPLVVKFNYEGVSRKVTFNSSRACTYDLLKRKVEQCFPLSMTTYAITYTDDDGETTEITTEGDLTEAIRYFHPGGDDPPLSSAASILSGRSFGRSKITLRVKISVDYDGPSLSDTSSLASMDEYKQRNGSASSFSFSSPSVVSGRGEVDDDSVTVSSKDMGTRYDYHREGKGGAKTIASGPSREPLIRPSPQSRSSSLNDWDTETVSSIPQSSNARSLGVRSLPSIQDNGEDIPANLAEGSSAVFERLKMQEGQGAAVNHGASPLQSEWLRDQNERTIKLMLGDLPAPSESDQTSLNIIEDSDSAMSGALALQKDPRGKFYYAYTSGSSSVPTSAESGDDASSILYDADGSLVDSVDLLERDRRPTSMEISWIESQVITTKSEPTRPSSSNPHPPNHRSHSEPLLSPDPSIDPDLLPFLGDPPPPPHTTDCSKCGILLTTFRYVCATCGEKEPLSSDSERSVDGKGKAKDISETLSSPPRPIHSYPPVPLMYGAPSPSASSLTVVSDTENPFNDPHCMKFGRKPLPAIPSPVSPLSSPSSSTINGPKSNGSVSEGYELCANCFHLYGLDHVLDSTDQSVSSPGTDSPMDTTRRTPSERRRTASKKGQLRHAFHEKLWGLRGWTDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIV7</accession>
    <name>A0A2R6NIV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIV7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="250" mass="27169" checksum="A77E43738A87681D" modified="2018-06-20" version="1">MQMAPGKHPKPDFATRRMADSTWDAEMSPVVIIGEAKQARTGQDAAGDRDTSKSYEAQMQAAVFPTLLLLILIHLKGKKHEPPLPAREGKTAQASKASSLPPNFFVYGIYYDERSLIIYSHFPYLEKDRANPSDIGAWRFAQVKMGEFTLAHHDDDEQTNAPRRLKLGIALQGVHEHAVILEGIFTAELPHLPVLQKVPLASSRLSESTAAKESSSTGKSSTRTASTGKLSTQTASTGKLSSAKKSSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ43</accession>
    <name>A0A2R6NJ43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ43"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ43"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6435" checksum="BF07F74D156CCC98" modified="2018-06-20" version="1">MLALVFNISNAVGFTYAGLTGRDRDAKQKWASQLGSGWGMGGFGGQILSGVVKNSVGRVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ53</accession>
    <name>A0A2R6NJ53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ53"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ53"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1223" mass="135076" checksum="2436806EBE045015" modified="2018-06-20" version="1">MATTEYETSKIEENKSPSPENGSIARVAEALAKVDIQEDKPPALSEENAIRPLHVYTRSQVLLLSKSPLVQSPQGMPLLKDWFGDWNEQQVSAKKETETSTTSANPRDRRFRRDPEDGDAPARPSFRAALSQPSQMGNFRHQSLRTTERERDTDRERQRDERDREGQERLRNLSDKYDRERLAQSSSPQTLRNKEREPAPHLASSAARKKPGESSDDWRRGSEPSRAARDDRSDNARRDRDRDRDRPRDSSRPRRETSTTRQDREDRDRDRPRRGDDRDDVRRDRDDYTRRDRDDYFRRDRDDSPRDRDDRERDRFEYSRPKDTNADEDSRRWRDDGKRDERITARRERERDNGRWDRWEPSHDRERVDDRDPRSKRPTGREKRVGGADDGREKDDRKEREREKEPAWMETYIPTTPTEGILGARTDGELDGIQAWKRGMKEKERKEKGETPESTKNDSEPPVTPSDNPLDEIQLFKLMMKAAKKEPDQGQTSKPTSMSSTPLPAEPRPLPISKESSQPTTITLDSLTIPSNRAKDASALSPQTVSPSPNVSAPSSESARLFSLIGTSTGDTVSSRPMKPTTPLVSDHVPPAVSRMFPNPPGLSPSIPQMDRSTFDLSGPAPTVTPTLNPPAGSRLLAFGSRNIAGSGSSSVAPPKSLTPMEALHDNFSNHMAPGVPPHHNKLSVMTPGMGMNVGLHQGPDSVPSSGVEAQFGTNPRATPSDRSARSFSPFGQPSHAAYAADDIHEAMRLAQASEALRRQPVNQLERGSIGPGGDSPYIDLGRASPGFSVNGPGYDMAGTSMHGGGSIGKGSRFAKFFDAKNRDAQAGPTMRKAMGGPGFISTSPVPGQRPDVMVSNPLNADNRAMEDLFAMLQNSSQNHRASPQINQTGRMSAGGGGPFGHSPIDLQALQQHQQMQQQQFAHNARMDSLYDSRLDDRNFVPDGMVPGLRPTPRPRSREPTTLAFNDQLDDALHVNVQRHPQQQRSLEQMYSGAAPSLYNQQVAMARNGGIPLQQAQFRGGLNVIPPQNTLQGPSQRLPPGLANLGGRPPHDPTQYLNQHLGGLGGVHGGLHPNPPAQQSYNNFNGGGLGFNGNPGPRGPIPVPHQNQITANHLAALGHGNSMDPRGTNQLVGMNVGGLGAGGLGGLRNVSGGFNPQHGPTSHIQAPQMAIRQQQQQQQQQHQQHLPPHIISHALPHLQPQQLGGSSQGAQDLMALLMGGHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ59</accession>
    <name>A0A2R6NJ59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ59"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8756" checksum="E6A3D7D371BE14D0" modified="2018-06-20" version="1">MDRMLMLGKPRLYRTNDVPTLHALYKSSQSPTSIRRPGTEEAQDQVVMELLRYYGGVTGTWESSLNISEDGRAYGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ64</accession>
    <name>A0A2R6NJ64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001223">
        <property type="protein sequence ID" value="PSR72052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ64"/>
    <dbReference type="OrthoDB" id="3174721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="19850" checksum="2A72355F95D43004" modified="2018-06-20" version="1">MSRPRRATVDAGDDAPEKKRRFTLFRSRTSDPIIIVSTSSPSCAGRPNAVATIPDSVSISPSSPSTSSSSGRAVRAGSVYSSAASDDTSAEQSAPSTLGRVHEDAEPKSSEIHEDGLPTYASATHPSTPTTYMFTRCSPFAMVLTQEGAGMATGMYHISVGVNVWIPTCTVTTVRRGPTEDGPIVAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJL3</accession>
    <name>A0A2R6NJL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJL3"/>
    <dbReference type="STRING" id="98765.A0A2R6NJL3"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="352" mass="39877" checksum="30CAB117EDDC5F52" modified="2018-06-20" version="1">MTRLKRTATLRGVSIISRRIHGWSWQAFPIGMGTGAVYLTLIDLTVPPFKALTTIETLFYFLTIALFLLNTSTLLLQFLLYPRQAKRLITTPSTGIFVPLILELELNRDRYRRVYVALSVVVCFSMLMIWYNKPHDLNTFTPAWAFLTGFLDGNQANGAFVACGPPGFTALALLSLGEEAQAMYVDYGDPGEIWYVCSIVPALMLLGLAIFFFLFGILPYWFKLHKQLDEILGFGWILALRKLGQIFQTSFFNVWNTVMTIIMCITWIVLFVLTCVAFWEGKIFISANEDTIQDGRHVNWRLRKHAEDVELGRRPDVEQPIDSGVHSVDLLIPTPETTIPDPKHITATLCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK79</accession>
    <name>A0A2R6NK79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001188">
        <property type="protein sequence ID" value="PSR72422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK79"/>
    <dbReference type="STRING" id="98765.A0A2R6NK79"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="206" mass="23179" checksum="7319E542B46C954D" modified="2018-06-20" version="1">MGACLLKCQRYEHELGVRTSEGNTKSGGYKIGGVSLAVGVIAQTQKITKLRQVTKIPDNPNPKTPSKLKVRPDPVRPTRKAMKDQPRCYTIHAFGCSDMVYKVICPQDRQKWQMLLMVNKLLADHPHQETLAQVRKLKLFFTLGKECYHWISDPLLNLDPSPAEPSEVDQTAVFVGEDKEVVNVGAKQADPFQLDKHAKEDVKMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKL4</accession>
    <name>A0A2R6NKL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v11233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKL4"/>
    <dbReference type="STRING" id="98765.A0A2R6NKL4"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="257"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR72866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="416" mass="46841" checksum="5EADCCB415DBF5B3" modified="2018-06-20" version="1">MEKGMVSRLRKVSVSKRQAVLCRRLLPLPETVMESFSYPQFPRDVSTVYIALFDRVSNAAEIRSRLVKAVSMTGPEGEHEREIMNFAFIDARLICSRLHLQTAIYHAAVAHIQKSLRTKTVHSEVLWILNPSNNISEAIRRYGVSDDSTAVFVVRIANSTTDVKTKMQSVVKGDLVPISDLQNITDWGNVKKYNKLNNDPALKGAGPKEKYVVNEIVFTPKAAALFTATGVGLFFYFRYEKQKLIEERQKELEDKQVGRPNVGGPFSLSTHDGKTFTEKDLLGKWSLIYFGFTNCPDICPEELDKMSDAVEKLDPARDSVKQVAKYVGDFHPRLVGLTGDYNMVKATCKAYRVYFSTPPSAKATDDYLVDHSIFFYFMDPNGQFVDAFGKATSMDEVVARVQKEISGWEARLGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL25</accession>
    <name>A0A2R6NL25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001116">
        <property type="protein sequence ID" value="PSR73054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL25"/>
    <dbReference type="STRING" id="98765.A0A2R6NL25"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="245" mass="28700" checksum="F8C7631F47330B5E" modified="2018-06-20" version="1">MGGISRRNFGMFRSLCGDSNLQNVLIVTNMWGEVSEERGSARENELANDNQLFKPVLDKGARMVRHYDTFQSGQEILRRLVDNHPLPLQIQHEIVDEHKEIPQTVAGAELESKAMEEAKRQQEEEMRKHREAMEAAMRAQAEQKAREVEQARIAKVAAEARAREEYQRQVAQQAEAQRQEQARLQQIQRDLEAQAAARRAEEERIQRMREEENRRAREAEEARARHRAQVERLNRRRRKNDCIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLZ2</accession>
    <name>A0A2R6NLZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NLZ2"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="113"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="723" mass="80521" checksum="B129E1164FA0860A" modified="2018-06-20" version="1">MSPTSPISGYGNSNAGVHASRLAREKNRLTLRSYVHILLSSSTFASSPVLKSFLLSGPTRLSEEELEDARRREEADNMREDGRKRFAKEIKERVEGLRGAVRSVKGELLGKDGLTHVFATIKETQDIRSLPDNYKAVIEWARISLASTVFQHFVAADDASESFAGLKRIHGLMPYFMLKAALKISNPMSMIRGVLDLFLAQPFGGKSLLQRMFSGSLMEEVKALEEDIESVKDKVEDTLMCEKVKLFVYAPHEIQAVYKADAAAEDAHVLTVILRSGEEPCLNRPQLQRVHRASIAYKQYTDSHPDSDDEGPEDDDAWLYEDLILLAKLYGRLRDREQLIALIFEGTTADLLKDIITIFYSPLAQVYRAASISDSLGDLQNFINDLIRTVESTEELSQQDPARTVQIFIDLIQRHEQSFYSFVHKVHSKGEGLFDSLMRWIEQFLTLMRDGLGDRVSLEFLLPHTGQERLDIMKEVDAVARYHYSMKVAYEAKVRRRFGRTQGHSDADAEDEEAAAMVNGVVRDLSFGELVKGDADELAAQDTDEEEDSSSDEEGSSEEGTDSEESDSEESESSSEDTESDHGTEGPNARRTTPTPSLARSHTIGHSPVPARVPRPAMPKQSLDLPSPTKHAQSPLRDSRAATYGGQSPLRGLPPFPLASSSSSSSKKLPPLPPSHGQERRRSPVKAPQVAKKKPQGPKPPELHHIPKLLPLFVEIVRDVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM92</accession>
    <name>A0A2R6NM92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001071">
        <property type="protein sequence ID" value="PSR73509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM92"/>
    <dbReference type="STRING" id="98765.A0A2R6NM92"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1038" mass="116885" checksum="90C327EF7C44C3A6" modified="2018-06-20" version="1">MDLGIGVLDGALDIERRELDVQILRLYRNLWLEEYEIEPPPPSAALNAIGLSTLWRVVCQAVDSQLSPDAVGDFYVGHEAALKDILNAAWKAQRFEEVCRMVDDFLDDTDAEQTKLHKRLSKYVRKAWLPSPSVTLSSDELHDLWDTVCGTVGPQLRFIDFHTFYRDNKNDLDDLLNTAWKTQEFKDVCRRVHKAFNIPYSGRSPGAILDPAAALAWRAPYQLDSHKMLYATINNMYTAAKIDGYGDYWNNVSVVQSSGTGKSRMVDEQATLVVTCPFNLRQEESSYSAYPDASIRDYLINTDGAVDVEVHYHLFFICLFRKLSAHFRTIKGRIPRQKMATDWKNHLKDRVRYKFYKDLIDDIEALNKTFDSSETTHNLQLKAMITGIEELDLLVKIIRARTSDSDDSVQLVIYFDDAQPLFKTDFNNGKSYFQSLLDVLCAYRMDPVFVVFLSTISHLGRLPAVPQGNFSSARAHIHQTHQATITELPFDCAPPEYYPPVQPYTLTVEDITQIPFMARFGRPLYWAMLSTLEGTELEKMSQTLIEIIRGKLIDERTDISPDNTKQYATSLAPLAVTDVRLCLQYAQHTVMDTHAALVASHMRIAYSAPRHRGRFHSGYSSEPILAKAAAKQLEIWRKKSSTALIDPLLACADFMDFEEREQLVARALLVEAYDAAVARTHAEVMANKAAEPSSASASTDGWCKAVHFIEALFQEDYAAAILDSRPDNTVGSTLREVLKESTVHFTQWVRAFDDHVVTTLAMAPAFIRGMAFICCYDQPQIDLLIPILLSNTTIGESHMSAFLIQVGQREDGVIYPISAETLGFFKYPKTARPNQRPYISLVMDLGVRVPLPNSAQHPAISPALSDISKAQNIAGLRQVGTSSIQTQKQPMAAKSEPGKAKTAPSRVNVNSSPLPSTTNMEKDEPWRYTIHAFGCSDAVYKAIRPEDKQKWQKLLMGDEILVDRPHKESFALGKESYHWFNDPLLNSDHLSVDPRGPDQTAVFVGEYLDEVNANVSPPRSVKKSVEQDNTSNEQPQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMT4</accession>
    <name>A0A2R6NMT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMT4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5671" checksum="61DD6E9023EBE29A" modified="2018-06-20" version="1">MELLYNSAKGENIQTDKTPGQADVSQESRPSFCTPKLHPIKVIARSANVTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN74</accession>
    <name>A0A2R6NN74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Metal resistance protein YCF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v10387</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NN74"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="853"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="924"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="199"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="531"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="813"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1132"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR73817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1372" mass="151653" checksum="0C0F9825091B91C3" modified="2018-06-20" version="1">MLFGLALAASIANLVVVIATKRHVPLIEFYVLEVIALAVVPCITYLNHYRARTSSSLILLFWPTYILALLIWARTVYLSNFTAFRVVLALRLAVAVFGLFAFVLECFGPEFTDEDHTEVYVKGHVESPLLTANIFSIWTFSWMSNLMKKGAKAYITEDDLPSLVPKDESVNLGDALRNAMKKHKSLAVSLFASYGGPYVFAGMLKLLQDCLAFLQPQLLRWLLAFISNYQSARLHGSESQQEAPSPLEGFAIAAIMFLASIAQTIFLHQYFQQCFECGMRVRAGLVAMIYQKSLILSNDGIGSASGDIVNLMSVDAMRLQDFCTYGLIAISGPFQITLAFVSLYDILGWPAFVGVAIMILSVPLNTLTARFLKKMQEKQMKNRDHRTRLMSELLANIRSIKLYAWENAFIRKILFVRNEQELKMLRKIGVVTSLNTALWTGIPLLVAFSSFAVAAFTSDTPLTSDRIFPAISLFMLLQFPLAMFSQVTSNIIEALVSINRLSAFFNADELQADARQIIKAKPRLEAGDEVLSITDGEFSWSKIAPSPTLEDINLAVRKGELVGVLGRVGAGKTSLCSAIIGEMQRREGEVKLHGCISYAPQNPWIMSATIRDNIVFSYEFDEVFYNLVLDACALRPDLALMPQGDMTEVGEKDQVIGPYGLLASKGRIVITNSISFLKYFDKILYLRRGVILEAGTYEDLTNNNESELFKLIKGHGSLGSSGVSTPFLASGSHSTPSSATAVDSSREVTVDNLDTLTEKLQRKRSFTKAVLVASPPTRTPASEGPSKEHMEQGRVKRDVYMQYVEAASKTGFLLFLIATVLAQIVSVAANNTLRAWGEHNREEGANQGVGKYLVGYGAFSLLSIILGAAAAIIIWVFCSIRSARQLHDSMLYAVMRAPMSFFELTPTGRILNLFSRDTYVVDQVLARVIQNVVRTLCVTAMIIFVIGYSFPLFLVAVPPLAWFYTRVMVYYLSTSRELKRLDAVSRSPIFAWFSESLNGLSTIRAFSQQEVFIANSDRRVDRNQICYLPSISVNRWLAVRLEFVGASIIFIAATLAIVALITSGVDAGLVGFVLSYALNTTSSLNWLVRSMSEVEQNIVSVERILHYVKLTPEAPAEIPGTVPEDWPSEGEVEFREYSTRYRPELDLVLKDISMTIKPKEKIGIVGRTGSGKSSLLLSLFRVIEPTSGTIHIDGVDITKVGLYDLRSAISIVPQSPDLFEGTIRENIDPTGASQDADIWVALEQTHLKHYVESLEGGLDAAVKEGGSSMSAGQRQLLCFARALLRKSKILVLDEATSAVDLETDRAIQGIIRGPQFADVTMFTIAHRLNTILESDRVLVLDAGKVLEFESPKNLLSNKESSFYSLASEAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPB6</accession>
    <name>A0A2R6NPB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000996">
        <property type="protein sequence ID" value="PSR74310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NPB6"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="497"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="706" mass="79199" checksum="5CB95F0DE85F9516" modified="2018-06-20" version="1">MPSTPINSGPTTRRSGSNTGDTNATHAIPLIRSWRSVSKNWKRISSKSKHDAAIPPLPVDPIKPSQALSSYDLTNLELSANRIRSKWVQKKQCYVIEPDDEGDNEGGDGPPSYPPTHIVTVFRTFSPSPGNPNVLSISKKIHVWSPYLVESVKAVMKDYMSISWTAKPVVLDPDDILVFLSQFEEHLYLLQMKGKDGNVKGRAEVISHLTYFLDFIGKEYENTLTTLGSLLEERKISFAFVWGAFLPGTILITTCGITGEPLAVRLRTCVRQCATHREAEHWALKCEFVDVNKGLPGYAKLVVKIYDFPGAKSITDLPAFPMNPYVEENQRGELYERLIKRGQRLWDLSSRSWSHNNYNAIAYSAVGASKINVKSRIVLDRERYIQYAYGDPLPTVKRDLDRKSLDQKILSAKADARRVDMSVDELLLMPAELYGFSLGDRKWLVFNVEDVDDIHWNLEAFEYLDLLDDKKEIVQTLIESHTQKAAIFDDFVPGKGLGLIFALHGPPGAGKTLTAEATSEVARSPLYMVGAGDLGTTAHELDGALTTIFTLASAWKAIVLIDEADVFLERRDVHDLVRNSMVAVFLRQLEYYTGILILTTNRLGTIDHAMKSRIHISLRYDPLNMETRSRLWQAFLKKAGLQSGEDNIVDAELMKELCQRPLNGREIKNTIKTATIFASYHGRAVGVRDVLRIVQTTDDLSEVNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPE9</accession>
    <name>A0A2R6NPE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000996">
        <property type="protein sequence ID" value="PSR74335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPE9"/>
    <dbReference type="STRING" id="98765.A0A2R6NPE9"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="668" mass="73037" checksum="CD39C4FC45387B18" modified="2018-06-20" version="1">MAVGPIYPKPVDDKDMNEDLKSEPPAYSASTSEDPPAYSPPSSFTINGQSLSVPLVTIQQLKSHLRLLRAFKELRTVVEEGKDARLPENVRALEAPPRWGWFVGLAVERFQRWAQTVQLGPLDEWVQHELPPIDVLMVWHAYTLNPSWYAEDCLRLPIAATLQALNDRLLTAIVAVGDIGSYKASETRKISWAEMTSTPFDPLDAAAQMAYHDVDCAQCLACVSVPYITSDGTGYAQHKFAFTCPACGFAISKESLAVLKFARDVAVNHRDPAEREKSPYGIYLAGTLRTSTNPKDEAIAQIIKDIIHRKADFSQPPAATKEQWVKAIVKQTECSMLKVLATLNVAMQSNRRRVRRMLSAYTDDRPFSIDLVGAVVRQCSFVDKMHHFGWTEPGYFDDKEDEVVLIHAIARYHGFLDLMSSSITSFFVPTLDIDLAWHTHQMMTKTYQNDCAQYCKRYIDHDDKVEENHLATSFDITCRAWEQRFEVPYMHCGCPLPGDTIGQRLTRLKRRLSNASNTSNGLIPPHRADALSATHASEHNSVLVPDHKLLTESQRKKRAEKVRKRRERDEKNVREGKMDESALRRGRDHDAAFLYPVPFYAYTPVGGCVAYGGIGAGGLGGGFASCAVGAGVGGCASGGCGGGGCGGGGGCGGGGGCGGGGGCGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPT1</accession>
    <name>A0A2R6NPT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPT1"/>
    <dbReference type="STRING" id="98765.A0A2R6NPT1"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="38250" checksum="8ADD034493C42384" modified="2018-06-20" version="1">MPFGEVVCGSPGSGKSTYCYGKHQLFIALNRPIAIVNLDPANENIPYPCAIDISSLITLDDVMNEHGLGPNGGMLYCMEYLEANYDWLEDRLKELGNEAYVLFDLPGQVELSTNHESVKRIVKKLEKSGFRLAAVHLCDAHYVTDASKYISVLMLSLRAMLHLELPHVNVLSKVDLIQQYGDLDFNLDFYTEVQDLSYLENTLSSSSPRFAALNMAIVSLIEDYGLVGFETLAVEDKESMLHLTRAIDKANGCVFVPPQDAKVPDGAVDATDAPPTQKPNAYGLFATAMGAVKGPRSDPRDVQERWLDAKEEWDAYEKAQWRREGQLVQEENAKRSQIRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR08</accession>
    <name>A0A2R6NR08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR08"/>
    <dbReference type="STRING" id="98765.A0A2R6NR08"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="210" mass="23972" checksum="352433A31DF9A5A0" modified="2018-06-20" version="1">MIASFLRYFNRWWDPMQSSREAIITLRQQTDMIDRKGEYLEKKIDEETEKAKASVLTDKPVAIAALRRRKATEQEFERLQDARLQLEIQINTLESANLNARTLGAMQRANTAMGDTHTQLTALHSALSQFREYNTRSTIDVLRSEPTCSTLPGLDGDELKAELEQLEQDVLYEQRVESGELPSVPIYTLPIVDDGAEEEELEQLQLALAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR43</accession>
    <name>A0A2R6NR43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000938">
        <property type="protein sequence ID" value="PSR75054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR43"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6919" checksum="2BD47513B39D03C3" modified="2018-06-20" version="1">MVSDGRGCISGGQVKDNDVEIAEEHEEDSEEDSEEMVEDGDVEIAEDDDIDKWVEDDSDKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR62</accession>
    <name>A0A2R6NR62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000931">
        <property type="protein sequence ID" value="PSR75093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR62"/>
    <dbReference type="STRING" id="98765.A0A2R6NR62"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="331" mass="38069" checksum="590C4A7E5E098C4E" modified="2018-06-20" version="1">MHNVIDVIPLGNVPWKCFSVKYNGAVPENNPPSWMFQFHKIYYCNPDAVICQMHNNLDFADSFDPVPRHEVDAEDWQVFSDFMTGNWAWRKTNKIAENPNSKGAILVPVISGSNKTTVSVRTGQNKYYPLYLSIGNIQNRICHAHQNAVVPVAFLAIPKSRRQHNDDFAYRIFRWQLYHQSLAWIFKTLKPHMETPTILCCPTGGHCARVVPKPFTNNFPHADIHKLLAPDLLHHIIKGIFKDHLVTWVGEYLTIKHGALVRNKVMDDMDRRIMELKHIKAVKKPWRWSSHFEALGQMLKTSQRLSELAAAHADFKKHCMLHGTALSDALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRE3</accession>
    <name>A0A2R6NRE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRE3"/>
    <dbReference type="OrthoDB" id="2801952at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="480" mass="53534" checksum="1B84C47101FCA35F" modified="2018-06-20" version="1">MVFCAGCFGNFNPRKGYTHHLSSSPACNLVVQNPTNKESPFDESQPMAVDEVDSDEEDHLDVENIPFAGDYFGNEYSAQDFGWEEGLQWAEGIDTGRSDSSDDEPDGLDNVQDLGWEPARSPSPSGSSPAQEETRGSTALHTIEANPNERLRVEEALQRPIQRVLFPITSAGTPIEDRCNDTAAMAGYRLYETQLHPDTATDHNREKDMYAPFASKLDWETARWAKLRGPGSTAFTDLLRIDGVPDKLGLSFKNSKELNTLVDSLPAQRPKFQREEIVVAGEAYDVYFRDVVECIQALYGDPEFASHLVFLPERHYADPDHTMRLYHDMYTGKWWWAVQKSIEESKPGATIMPIIISSDKTQVTLFRNKAAYPVYITIGNLPKDIRSKPSQRGQILLGYLPTTKLEHISNKAARRRTLANLFHACMSAILLPLRRLGVEGMEMATGDGVVRRVYPIFAAYVGDSDVPGPAWPESPGFGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSJ5</accession>
    <name>A0A2R6NSJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA2/NAM7 helicase helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSJ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NSJ5"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="7">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="309"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR75786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50998" checksum="CA19AD6B450230E7" modified="2018-06-20" version="1">MAFEISNDDQLRAFIDKHRSLLVKEREVEIERTSLLLSSCSPSLLEQKGLALGGLGIVNVNIGLGGKTSGDLARIEEHVFSSAGTKKSSKIRKPSETKGTRLFEGVVYKAALAKDVKSELESMLDLLSGKGKATKGKAPKGSERRKMWEEVRALRKDQVVLATCHSSGGWQLRNHVFDVVIIDEATQALEAVCWIPILKSKKLILAGDPMQLPPTILSADKRDKSSLTKSPRPTRQSKPVAKLDKETPTSSTPAPEPASEPDAESGGSDGDSMIASDEEPVIEAVDSAPPTQKKKASQISQRLRPPRSLEITLFSRLEQMYGPAIKRMLTVQYRMHAKIAAFPSKVMYHSKLNSHASVAAHLLRDLPNTKAESEEEETELLGTPVAFVDTAGCEYFERTEGDGDEGSRCNENEATVVKRCVEQLREVGFLKDKRRLNDDEYVSCAKRSPSDNSPPPKQLILNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSM1</accession>
    <name>A0A2R6NSM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSM1"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="383" mass="42563" checksum="167080213762EFAB" modified="2018-06-20" version="1">MASNSYSSAWARDEPPSPKEEVPPSPSRERLSDQRPAEHRPSDVASYQSSTADLSSAGPSRWWAFTRHRPGEDGSQPLAANAARHGRERSLSVAWLTHTITRRSGDNEGVPRDRVAEGPYPLHDAGPYAMQDQFHLDLPPPPSSPTTLAQTRTPGWETPWTPRVPGAAWNTVTANEEHENENEKLSRWQRRKKRIRVYMLTNTYVPLLFRFVNITFTTSALAIGIRIRITEAQHGITGALGASPTLVIIFAPLTLVHVMIAIYLEYFGRPLGLWRTSGKLAHTLVEVVFVCAWAAALALSFDNFFTSIIPCASHSSISWYNKLPRPSPILGINGTNGIGGTLCNEQVALICLVGVGLIMYCFNLIISLYRIFEKVKYHPTMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NST1</accession>
    <name>A0A2R6NST1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NST1"/>
    <dbReference type="STRING" id="98765.A0A2R6NST1"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="188" mass="20699" checksum="B97EDD96F76F2231" modified="2018-06-20" version="1">MEESIPSISSGAVGSRFITQSELETAKARRDEQWKAAYARCIAGPTRTRSRSNQFRALEEDEVLFLDSVLEKQREEERIRKEMDGEELKNFRQAVAARENAAKPPPIVSEVLPAAPSKTKPTTVTSTIAKKDTKKALKGVLVKKKSKPSAAASPTKTKLNVGESEIKPTADADVLPPAKRRRVTEPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTP3</accession>
    <name>A0A2R6NTP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTP3"/>
    <dbReference type="STRING" id="98765.A0A2R6NTP3"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15479" checksum="7DA920BA0100E424" modified="2018-06-20" version="1">MGFCRDDQPYIPPTKPYELSALASDLLLLARYMLKPGGRLVFFLPTVTDEYVELDLQTMLCEGMEVIANSLQDFGSWGRRLITVRKTTTAKFPPPTFDSSTSEKEANEAPAHVPAHKDFREKYFQGFKKAGSPDGDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTY0</accession>
    <name>A0A2R6NTY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta type-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000858">
        <property type="protein sequence ID" value="PSR76223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTY0"/>
    <dbReference type="STRING" id="98765.A0A2R6NTY0"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18846" checksum="D001A4FEEDFC9C09" modified="2018-06-20" version="1">MSDFQYIQTLLDELTVEEFTAGDHHELGPAEIHEYLSRVMYARRSKMNPLWNSILVGGVKDGKSFLAYVDLLGTTYSASTLATGYGAYIALPLLRKAVEGREHELTEEEARKIMEESMKVLFYRDARSLNKFQIATVKESGVTISDPIILETAWGFAEGIRGYGAQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU17</accession>
    <name>A0A2R6NU17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alanine racemase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU17"/>
    <dbReference type="STRING" id="98765.A0A2R6NU17"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="73"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="245" mass="26473" checksum="307589594B865536" modified="2018-06-20" version="1">MSSFVNAPVPKASQDRVAELQESLAEIRSRIQQACSPPHAPALVAVSKYKPASDILACYEDGQRDFGENYVQELEAKAQQTVTSAKAATGLNKYLPAERSAPLNILLQVNTSGEDNKSGVPPLSPDSPSADVELTQLARHIIKECPRLHFQGLMTIGSLTESLSSAEKENEDFERLKQTRDLLQEALSKEFPADSGKWGLDGRLLLSMGMSSDFEAALKAGSDIVRVGTGIFGTRPKKTETVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUN8</accession>
    <name>A0A2R6NUN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000815">
        <property type="protein sequence ID" value="PSR77064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUN8"/>
    <dbReference type="OrthoDB" id="549336at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51656" checksum="CAA81E56D14FB476" modified="2018-06-20" version="1" fragment="single">LEEPVSLEKQASPLIALKRRNVAVASSFVHHFDVYMALVWTLESVLSNEGSHSIRVFAHPFNYGFQTVVEKLGLYQGARGLPDDFIPYLISEVGAAVDVVVLGTCEFEYVLHLSRAVVLIRWLILSQSLRSWHTELLSAWDMRPQAQKFQLVCMVHNVKDTNWQSHITDWARRGAIRLFPIGEQHVFNEHADSTDVSMYTAGYENIPIDVYAPVLNIPDLPQKDLGRVLSKAVIQGSFDVGRRDYPRFLADLVSSFHEDPESWGYHPLEGRASFVPNHRSPEPPFELAIVGSGALQIPQVLAYVITVYHDVDYDQFYKLIASMDIVVPAFADFGYYEDQASSTIALAVELDIPILATKRMRQAYGYIDDDRVVVTRPAAMREVQALKALRTRNSTHFLASDPAGDGRKMADVPGLETAVQKMITQGWARQKEAVTQYKKELWGNNGKVVEHLLEFDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV44</accession>
    <name>A0A2R6NV44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000805">
        <property type="protein sequence ID" value="PSR77234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV44"/>
    <dbReference type="STRING" id="98765.A0A2R6NV44"/>
    <dbReference type="OrthoDB" id="3239894at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="277" mass="31529" checksum="4D78C74898EBCCE1" modified="2018-06-20" version="1">MEHEINKWRQTPSAVGRLDRIQDSAISNGGKFFDNSPERDAPKEPQVAITLGFDGLTPGPKELNADELQFFMKAFVNDLLKLYNHGILVKTANSPEGVTKMQWFEIWIKGNALRESTEKAPRELDAIHTYLKAFEMPSWVARLPKEVGYPAGGSLTSDEWKAMLLLYCPLVIPIIWKEWGPAAEREYQVKLDKWQKKKGDKPAEPKQRMQPENTDNFLNLATAMKILLVQSISINDIPLAKLQLQNYLRGFQSDPKYPSPSALLFFNYASIFSLNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVF4</accession>
    <name>A0A2R6NVF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVF4"/>
    <dbReference type="OrthoDB" id="3237202at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="407" mass="44265" checksum="4AC93264143E5273" modified="2018-06-20" version="1">MVAHRGFSAWITCGEKRLQEYEVVVDTKTNKVSCWIPCAVGQKFSVHWEDEGTGIDSAGFIILDGFTVPGQFLFGEGETERSSVRVADNAERPFVFAKVQPGQGPATALSNMKEAGMITLKIKQIKRTSLDHNPNTPRRPPPPIQGRRNIAQACVGYGAKRDTEAQHPKTWSCEPYDKANPGSLVYFTFRYRTRNWLIDQGIMPAEDYEDEPVYYEDVPAREDVSAHTPGSIGSHPDTPPSTPSSTMSKLHTPSSTTSALGSAGNPLPISRQPSRQSVRSVRSQATTSNLGDRGSSSSPTSNQGHDASEGTSKRTTRSRAARPSPYYRSYSNGGGGASGSASTPELVDATAGAPADPRRPYYRSATSTPANPTKPLPKIKIPVDSHISNSAKTYFYHHKFDNDNNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVN0</accession>
    <name>A0A2R6NVN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000785">
        <property type="protein sequence ID" value="PSR77678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVN0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="8018" checksum="FD15080FF310A1C6" modified="2018-06-20" version="1">MSNRNAALKRRSVSRVPDTNDTNRKSLDNNSARPTDISIFSNMELFNEPAPSAYNILTSASPGTSSYIQSSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVN4</accession>
    <name>A0A2R6NVN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyadenylate-binding protein</fullName>
            <shortName evidence="13">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v7940</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVN4"/>
    <dbReference type="STRING" id="98765.A0A2R6NVN4"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000441">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000520">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="137"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="230"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="333"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="16">
        <location>
            <begin position="594"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="476"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR77339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="676" mass="72678" checksum="B923AA1C17D31EF9" modified="2018-06-20" version="1">MSAAPAVAQSQDVVPVPEAAPVPAPAVAPVPAPVAAYNPPVPQMPSPSASLYVGELDPTVTEAMLFEIFNMIGPVASIRVCRDAVTRRSLGYAYVNYLNANDGERALEQLNYSLIKGRACRIMWSQRDPALRKTGQGNIFIKNLDEAIDNKALHDTFAAFGNVLSCKVATDEHGHSKGYGFVHYETAEAADTAIKAVNGMLLNDKKVYVGHHISKKERQSKLDEIRAHFTNIYVKNLDPEVTQEEFTQLFEQFGLVTSAVVSVDDEGKSKGFGFVNFENHEEAQQAVDALHDSDYKGRKLFVSRAQKKAEREEELRRSYEQAKMEKMSKYQGVNLYIKNLDDEIDDERLRAEFEPFGSITSAKVMRDDKGTSKGFGFVCFSSPDEATKAVAEMNNKMIGAKPLYVSLAQRREVRRQQLESQIAQRNQIRMQQAAAAGMPGYMNGPMYYPAGPGFPPQGGRGMMGYGPGMPPMRPRYAPNGQVAGMPMPPGPYGQGPPQPYGMGGGYTRGGAPRPPPGSRGPPSSADPNAPNGAAPRAGPPASRAPPAGVPAGGARPQAQGYKPPVRNAGQAPPPAPAAGAPAGATPASVPAAEAPVLSPVQLANASPMEQKQMLGEVLYMRIVASQPELAGKITGMLLEMDNAELLHLLETPDSLNLKLSEALAVLQEFQNQADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVV8</accession>
    <name>A0A2R6NVV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000770">
        <property type="protein sequence ID" value="PSR77857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVV8"/>
    <dbReference type="STRING" id="98765.A0A2R6NVV8"/>
    <dbReference type="OrthoDB" id="2717295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="220" mass="24982" checksum="DE7E0C051CA1DBCF" modified="2018-06-20" version="1">MLLDIFSVVGTYSVKPKEQYTTDNAEKSRILHDIFFPPPGDPPDVPDNFDFPREKFKFKGITRNLIRSVVAGLKCYKAPGQDEVPNEVFKWCIDLLLPFLFRIFQASIKLGIYADDWKVSRSCVLRKPGRDNYSLANSFRPIALLICIAKILSACVAKILTIQSERLSLISNQHFLGRPGRTCSDSLHFITSTIKDAWRRKDVASVLFLDVKAAFPTPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWF8</accession>
    <name>A0A2R6NWF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWF8"/>
    <dbReference type="OrthoDB" id="2987506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="221" mass="24071" checksum="4EBEADC97BDEC0BE" modified="2018-06-20" version="1">MSAKYTINVLIDPSQVEILRKGGFKLCLAKDTNHDVDVIWQAAEPVIKTTFQWTAEYQVFRASSFTPGALVSAMSNSVQIESGQTAVLDKFGVMRPATGIPDNSGVFFVRNEYGSMFIGIGAAHDGQWSSSYVTRTQSIGESETALTPVETVFLWFYPLVTAGTMFEHTLNGSLRLDLGNDQHTIDLVYTASGTWVILPSEQHRDASKGAEIGREAALVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWK3</accession>
    <name>A0A2R6NWK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000764">
        <property type="protein sequence ID" value="PSR77988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWK3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="110" mass="12388" checksum="BE1A700B11BB593F" modified="2018-06-20" version="1">MANQLRAVERTGHEESERLEGRCNEIEDADNDRLFEVVSVHVGVIRRDGLLLNLLLGPVRQKQLSNPAKVCGNSLEPVQELGHRTEPGDGERLVEKWLCYLSDIARDEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWN3</accession>
    <name>A0A2R6NWN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000740">
        <property type="protein sequence ID" value="PSR78464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWN3"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="405" mass="45075" checksum="574D547AFBD4E0A5" modified="2018-06-20" version="1">MQHISDLVQQALSALPQMLKTILLRGTPAFFKWFAVTLFLINFRSWPLVWHYKVLFSPIFEVRARYYRLLLSTLFLPAQARLERKTKWLQSLCPVGEDPTKFVVSVDAWAGPDDCDFNWHLSNSSYPKTLDASRFRAALRICPTFFRAGGWMPLGATHFKFMKEIPIFAHYQIRMSIAAWDNKWLYVVTRYVTVPKKGKGRKVIKAPATAKTTREDKGTDGEIPSGDAARFPSLHTPATPSISGTSTPAVSANSSSIGLTTEQIAQLVPSEEPDGATVHCISVSELCFKIGRITVPPAVVLAAEGFSRLPPPPSSAPSPMQTPARYSLTNPPPSFARSQSLQLPDVSKGHLKTFQKFLKGGWKEVGEGERWWEDALGGEVEERRRVNLERVKGVRTGMEGALAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWT5</accession>
    <name>A0A2R6NWT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWT5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="290" mass="30297" checksum="5D69AADFB098E8B6" modified="2018-06-20" version="1">MESRLVETAEIEGSLWTEDVLKDKANEDETEGVEKNIVAGDPLIVGSELSEVTLGTASDVKAVSVEVGGMKVTVMKSVDRTVTVAMSLSSVEEAVIDGRLAETLDILREFKEDVGVGPEGSVASTGEMLKKLANDAMGMLLEDPAIELTGEAVCRLYIPTRAAEAVDGPSVDSELVSSSVSQSSSSSAGEGVGLDPAKVAVAACETSVAAIEEGALLELVPVKLASTPAACMRAKASDSKSHITVVPCWLTRGRATQIWSEGQVVSTQFPLTHWAKAVLTQAGLSSKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXJ3</accession>
    <name>A0A2R6NXJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXJ3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7348" checksum="85D7DB21C3579F64" modified="2018-06-20" version="1">MGEDLDHGDMEEVDERIDETDHDILARNVATSEESVLMSFEGFSLNNDLEIQEVDRTTPTISYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXL6</accession>
    <name>A0A2R6NXL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000696">
        <property type="protein sequence ID" value="PSR79404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXL6"/>
    <dbReference type="STRING" id="98765.A0A2R6NXL6"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="457" mass="51177" checksum="F2D416C93D7FCC48" modified="2018-06-20" version="1">MAHFMHMVIEGFERWPNSPLIRPFIGTTTEFSWGIITFQDFHRDLQKTAAYWQSVLTAAGIRPGAVVGLWLTGEQVTDLVNLYGLARAGYTPELFSLKFSLPGRAVVRALLEECKGEALLFDSHFADLVEGGDGMEVPHFRLVNVSDLPPIGNNNRLAPLPPVSEEDIAIIFHTSGTTGGRPKPVPQSHKWCKTHSRVCWKGIWQGNFDTPDVVNNIGSFAHMGASTYIYKSAFSGGSFVQTSRPDIGAEEFLAMVRMCGLNRLLQYATWLSALITVARRNKDVLEAMQGLRQVVYTGLAMNPEDEAWARDNGIPITVSPISYYHFTALMCDFGRIYMVLRRQVRYSEDCIPSYDTKSYARQAQCMISDLGSKENYIRPIPELGLQFIPSLQEDSALPPIVSNGDGTSQKQLYDLFLPLTALNCPHPSVCNRFDGHITGDLFEEVKPGYYIFREYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXX3</accession>
    <name>A0A2R6NXX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v6989</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000693">
        <property type="protein sequence ID" value="PSR79528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXX3"/>
    <dbReference type="STRING" id="98765.A0A2R6NXX3"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSR79528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="323" mass="35909" checksum="F1B7119785A531EB" modified="2018-06-20" version="1">MKFELRHAHGLSNDSSRVVFMDVPRSQSEFLSPSFEVNTRQLAIPRPRSYSRFFDARRERDGQHVLDWNDEQVPGPDINDRQTLLMLAKMTNNAYYEPGEKGWYDLNPEWNISYPFGWEPDADGFRGHIFATEDNSTVVISVKGTSAGWIVGGSGPTSKKDKLNDNLLFSCCCARVGPTWSTVCPCYEGHSKCDQGCLENSLVEESLFYSVGIALSFHIQSYTGHSLGGSLASLIGVTFGAPVVAFEAPAEKLAASRLHLPSPVRSLLFCCETPLAAERTSSSQVTTISHPYSILRTYITLQTLFQWERVPASLLRVPSQDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYG1</accession>
    <name>A0A2R6NYG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000693">
        <property type="protein sequence ID" value="PSR79532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYG1"/>
    <dbReference type="OrthoDB" id="3360976at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="2">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="21188" checksum="234CACF8BCFFF6B5" modified="2018-06-20" version="1">MELTLSRDSPTNTLILDAGGTPLYHICTPFKWTRRTTTIFRGGPSMRSPDSSVPPDPASSSLDGSTISPDSSEIARIHWNYVDSPRLVYDGRIVEFSKFMPAGGFMWMTRTFTAPDGKSYIWRMGWGSCHLELNDGSKPAKLIARFKEANLLKGSKSILEIDEAGLHILDLIVITWVFVEKYRRDGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYM6</accession>
    <name>A0A2R6NYM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Syntaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000653">
        <property type="protein sequence ID" value="PSR80468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYM6"/>
    <dbReference type="STRING" id="98765.A0A2R6NYM6"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Syntaxin N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR80468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="197" mass="21998" checksum="81C074153354C427" modified="2018-06-20" version="1">MSFQDIEAGLASPRSPTRPTLQSQEDSAFLTLQSSLSLQVFKINSNVQGILKLVDQLGTGRDSGTLRKSLHDLTETTRAMAKRGSDDLKKLAALQATLPRHKTSLQKTSHDFQLSLVAFQRAQQVSAERQRTVVEGVKHAVEEENSGQVPTLSLAKKPVLIEIAAMKSDRQVQLHRSDKHRYCKLNFLRTNWPIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYN9</accession>
    <name>A0A2R6NYN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000653">
        <property type="protein sequence ID" value="PSR80461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYN9"/>
    <dbReference type="STRING" id="98765.A0A2R6NYN9"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="4">
        <location>
            <begin position="187"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR80461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="297" mass="33336" checksum="7F86CA3DB414522A" modified="2018-06-20" version="1">MSAAAQVARGTSTGRRFTAKLIKPLTRPLRKDRNRLPIPHVHIVVRDTHQCRLLEHYHTTLRDNLMYMSYVHEPHGRKPMRPIRPKFDPEDPYVKHRFNPPIGPPAWVRTPMPPVTPENIVQLECIQLHMMVKESITSKSNLLGPIMAFRAISGESERAGGRHTVEGVKIVKGKKAIGGWVKKGLATGVKVDIRGPKMYDFLGTLVNFVFPRLRQFDGIPMPNASVSLETPSAASGVVSFGLGPESFSMFPQIEVNQDRYPKTYGMHIHLITNAQGLGAQNRARQLLSGFQVPFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ31</accession>
    <name>A0A2R6NZ31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4792</name>
        <name evidence="2" type="ORF">PHLCEN_2v6590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000632">
        <property type="protein sequence ID" value="PSR80955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000483">
        <property type="protein sequence ID" value="PSR92031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ31"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR92031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="6917" checksum="1492D410E4EEE403" modified="2018-06-20" version="1" fragment="single">LPPSAGARGKYSVVSQGQRDAVDSRRCKHQRTRWVKSRSRVNKAASKTSLPETAANLSHDLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZG1</accession>
    <name>A0A2R6NZG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LamB/YcsF family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000623">
        <property type="protein sequence ID" value="PSR81276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZG1"/>
    <dbReference type="STRING" id="98765.A0A2R6NZG1"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15081" checksum="2B43DD6C2462E3FD" modified="2018-06-20" version="1">MDKTVLLAKENNVKVGAHPSLPDHQGFGRREMVMEPEELAACFIYQVGALCGFLTRYDMPLNHVKPHGAVYGMMARDLRLARAGMSVAKTFNVPFMGLAGTCHQEAAEEMGVPFIAEWFADLEYSPEGKLIITKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0C0</accession>
    <name>A0A2R6P0C0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000599">
        <property type="protein sequence ID" value="PSR82132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0C0"/>
    <dbReference type="STRING" id="98765.A0A2R6P0C0"/>
    <dbReference type="OrthoDB" id="2797114at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="511" mass="55693" checksum="33DF92B2483F955F" modified="2018-06-20" version="1">MTTTVALDINFEEWLGGALAGLQDLHLVSPPSPASNCSSPLSSVPSSPTISSPLSSVPPSPTISSSPSLSDTHSDTALLTLMLPGPLLPPMLTPLLPPPLPPAQPLTKNQKRNQKANVRRRRKRALAKSPTSALDYKVRLKHLCKPSEAANYTVDIGMDECNRAADGAWIGLDRKKGKGKGKRESDGDGDGDGDGDGKPKSVDDFKRLGFKVFEWDGRKTVTLTDKQGTIIGVLCDQPPNSAGSSSWSETCQGLTTALQQVEAELDFSQGPVLPPPYQGCNDNRRGNFKTASFGVSYGGGQTKPKELAHTPYNQDVLDGFKKNPHLARVVTYASSMFAHYAPRLYDYYAKNFASLKTSQPELKLPVDTSIFTTISFNLASQVVASEHKDFKNLAYGLCAICALGNFDPKLSGHFILWELKLLIEFPAGSIIIIPSALFSHGNVGLQAGETRYSLIQYSAGGLFRWVKYGYRKWEKFKKQDPKKAKAEWSARPTRWQEVLGLFSNVSEFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0L2</accession>
    <name>A0A2R6P0L2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v6248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000606">
        <property type="protein sequence ID" value="PSR81817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0L2"/>
    <dbReference type="STRING" id="98765.A0A2R6P0L2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR81817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31597" checksum="3DFBC57362224CCA" modified="2018-06-20" version="1">MDVNSKAIFYEKKTALEKGDAAVSQQVDEGKDLLSLLLRANINVAEEDRLPEAELVAQLSSLVFAATDTTSNALSRILHLLALNQDVQQKLRAEISEARNGEDLTFDQLMNLPFLDAVCRESLRLFAPVTFVSRETRQDTVMPLSEPIHGKDGNLVHQIVVPKDTTIIVGIRGCNHSKAIWGEDVLEWKPERWLSSLPESVSNAKVPGVYANLMTFLGGGRSCIGFKFSQLEMKVALSVLLDSFKFSLSNKDIVWNLAGVSYPTVGAVSDEPSLPLKVEAIAGKMNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1M8</accession>
    <name>A0A2R6P1M8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000557">
        <property type="protein sequence ID" value="PSR83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1M8"/>
    <dbReference type="OrthoDB" id="3235847at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="167" mass="18555" checksum="1B45F6BB751E4D81" modified="2018-06-20" version="1">MDPIISWAPISYASSVAFDTVILVLTLAKVHSRSMPRSHLGERISQDNLRYFMLATATNIAVLSIQALGAEHDMIKPAAVPFSTVMTVAMGSRVYLNLKLYDYDHNHERGSRSTDIPLSVTSGYSESTGERTFQSIPTSVMNSTAYCSTLTKEDKTVHPYSYTGYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1P5</accession>
    <name>A0A2R6P1P5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000557">
        <property type="protein sequence ID" value="PSR83532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1P5"/>
    <dbReference type="STRING" id="98765.A0A2R6P1P5"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="154"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR83532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="399" mass="44480" checksum="C93ADEE334BF16FA" modified="2018-06-20" version="1">MPVTSIVSDSMLDTALWYTSLVLYLFACILIVTTPRGPPLHFPPERIYSEKTVMAITSRRKDNVSSITGASVWDILYFNYTTRIVTLANTCASFELGDLPIVPGDIRAIALFAGMRTAMRKWRLRIGSWQPKPGSGWELAYILIRANTSVLCSVVGLTMVSSVLFYAPAFFMRGLVRYLEADPERTNWGWGWMYCAGMFFGSFICQLTSEQLFGVACTTLLVRLRVQVNSILFAKTLVRKDITSSAAGDDKKNTSSDAENSNGDGAGPANEKQDGNEFSSKAQIMTLMTIDVSRVSALAWHIFYLFNTPIEIVVGTLFLYSLLGVSCLFGLAVIILCLPLNHFTGSVVVGAQGKLMKARDERIALMNEVYDHFVSMIMHSSFIRDLRQYQDDKGRLRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5Z9</accession>
    <name>A0A2R6P5Z9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5Z9"/>
    <dbReference type="STRING" id="98765.A0A2R6P5Z9"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR85826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="420" mass="47753" checksum="229969277A8F1F0E" modified="2018-06-20" version="1">MVSGPPNVYALEIPKRPRQTWTQTFYAILFVLVFDIGCLMINGFQFVVLVPLKLLPLPGAHKLYDEAARYSKGAFGTLIGTQIFAPTTLVVSFEREGLGRFSEKEIKEIVERDEAGKVVALRLPQKAVMIANHQVYADWWYAWCLTYLMGTYKDVFIVLKKSLKWVPVVGWGMQFYNFIFLARSWASDRLHLSASLSWLGQRAEKQDTPLTFILYPEGTLVSKDTRPLSKKYADKMGIPDMQHTLLPRSTGLHYSLRSLAPRIPSLQLIDITVSYPGIPAFGYGQSYYTLRSIFLDGVPPPKVHMHLRRFDVAMDVPIGNLSKSKPPTIPNGGSLKPPSKKEVVEIEIPQDERDTFDLWLRNLWKIKDTEMSQFLNTGSFVGDSSLRVEIPVAIRRKREMLDAFAFFVPALVGWILSRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBX0</accession>
    <name>A0A2R6PBX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000504">
        <property type="protein sequence ID" value="PSR88663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBX0"/>
    <dbReference type="STRING" id="98765.A0A2R6PBX0"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR88663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="412" mass="47053" checksum="C39A968F467E9720" modified="2018-06-20" version="1">MPRARLQHNPLRFACEHCPRSFTTQSGVKRHTKQQHPPPPRTSTHVPHNNNHGPDNDSDSDSDDDFDAHLLSGDSGNHLTPGIARVEYHNVLNAVPCNKNGLDTLAGAEPPPQDVEDGWFPFQNRIEFELAEFLFIEEQMGQQKINRLMDLWAATLLKHNDTPPFANSKDMHNTIDAIPLGDVPWKCFSVKYTGAVPENNPPTWMFQSHEVYYRDPDAVIRQMHENPDFADGFDPVPRREFDKKDQQVFSDFMTGNWAWRKANKIAENPNNKGAMLVPMIPGSDKTTVSVGTGQNEYYPLYLSIGNIQNRVRRAHQNALVPIAFLAIPKSGRQYDDDVAYRTFRWQLYHQSLLRIFKTLKPHMETPTVLRCPDGHFRRAIYCMGPYIADYPEQALLAGVVQGWCPRYVFCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC86</accession>
    <name>A0A2R6PC86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v5058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC86"/>
    <dbReference type="STRING" id="98765.A0A2R6PC86"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="7">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR88909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="16136" checksum="CE960B689E23C419" modified="2018-06-20" version="1">MRSKFKDEHPFEKRKGEAERIRQKYPDRIPVICEKADRTDIPTIDKKKYLVPSDLTVGQFVYVIRKRIKLAPEKAIFIFVDEVLPPTAQLMSAIYDEHKCVPVLSFVSYVRLTSTHSSDRDEDGFLYVSYSGENTFGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG82</accession>
    <name>A0A2R6PG82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000495">
        <property type="protein sequence ID" value="PSR90478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG82"/>
    <dbReference type="OrthoDB" id="3308063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="243" mass="28186" checksum="8F04244012ED2194" modified="2018-06-20" version="1">MGYSVTVNIYSFEGADDPNFELGEFDKDNFPAEVIIPTEDKYSSVCFAMWANMRDLGISPIDLDPEIKHIAEIAPFDELPVSLDPPAVRSRHAPMPPVMYYGWEIDQNKWFEWAKDHGYSVMYNLITFEGADDPNFDLEDFEDDDELPPEVIIPTVDKHHSVCYALWTIMRNLGIKPVDYYPVKATLGGGEFTRLVVLTDNYHDDDSLTEENLEKLQKILGRDDVPKWYPSTYFQWNRDRDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG91</accession>
    <name>A0A2R6PG91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG91"/>
    <dbReference type="STRING" id="98765.A0A2R6PG91"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR90838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51786" checksum="7B597F9BA88F79EF" modified="2018-06-20" version="1">MASFPGPLLNKLTTLTLLHTVSTGKRHLIIEALHKKYGVFVRTGPNTLSINSLEAVGPIYSSAQCFNRSEGYRPGRFGDNSLFFIRDRQRHNIRRRVWAGAFTPAMIKNHDDVLNERMRQLVACILRRQDNLGVVDLSECFRHWAFDVMGDLTFGEASDIELMRNGDPEGIIAGAQKAMMQFEILGEVPPLFDIGYYLPASKDLHYLETLAARFLVNRKKSASKSDTDLSSFLLGYHDEEQKEALRDEDLNMDAVFAIEAGADTPAGVLTLLFYHLLSDRTVYNHLKEELDTTFSIGEIGPEDHASLLDLPYLSAVVQEGLRLSTPFPGLARVVPKDGVVLVNRYIPGGTIVSVPAYAQEVSPENFWPAPLEFRPERWLEGGLGPDSILRPGALVCFSFGPFGCLGRQLAMRELHLAVAQLVLSYDITLAPAFNEELFMDGVRNIKTTLFKFPLLVQATVRKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG92</accession>
    <name>A0A2R6PG92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG92"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="14256" checksum="30A261621E4F25D8" modified="2018-06-20" version="1">MLNLRSSQSVDEGGTVFIQGPLNFIHTNLLGDLGDSLEYNSDPGYSDDTSIRNSLVETSTPSDGTLTLTQSPKHPRFAWAAEHLYATPHGRNSDSPNTSSGNSRSPEQEFEMQWMNTQHGLRERSDSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGW4</accession>
    <name>A0A2R6PGW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4801</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGW4"/>
    <dbReference type="STRING" id="98765.A0A2R6PGW4"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR90832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="604" mass="67890" checksum="EC4A3D41703E0229" modified="2018-06-20" version="1">MSQDKITRIAIVDANRCKPKRCAQECKKSCPVVKMGKLCIEVKPSDKIAFISEFLCIGCGICVKKCPFEAIAIINLPTNLDSQVTHRYTANAFKLHRLPTPRPGQVLGLVGTNGIGKSTALKILAGKLKPNLGRYDDPPDWQEILKYFRGSELQNYFTKVLEDNLKALIKPQYVDHIPRAIKGNMTVDAMLDSKLELDNKQKLCDELELNEVLTRDVSQLSGGELQRFAIAMTCIQRADVYMFDEPSSYLDIKQRLMAAEVIRRLLTSSNYVIAVEHDLSVLDYLSDFICCLYGKPSMYGVVTMPYSVREGINIFLDGFIPTENLRFREESLSFKMVETAEELVVDKTRQYSYPSMTKTLGGFKLTVEAGSFTDSEIIVMLGENGTGKTTFVRLLAGDTPDVETDKQTLSVSLKPQTISPKFPGTVRMLLLKQIKTAFMHPQFQTDVVKPMNLENIIDQDVKTLSGGELQRVAIVLALGKPNVAVYLLDEPSSFLDSEQRIIASKVIKRFILHAKKTAFVIEHDFIMATYLADRVIVFEGRPAVSATATPPQSLLTGMNRFLASLEITFRRDPTNYRPRVNKKYSVKDREQKASGNYFFLEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PK28</accession>
    <name>A0A2R6PK28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PK28"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR92241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5549" checksum="B87D9C50217DD758" modified="2018-06-20" version="1">MREIVLGTGKNSGSSYVVETLVFCPSAVQKLESRDTYETEIPDRLTVDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN29</accession>
    <name>A0A2R6PN29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN29"/>
    <dbReference type="STRING" id="98765.A0A2R6PN29"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="479" mass="51351" checksum="401CC23302314A39" modified="2018-06-20" version="1">MTSPQDNASILSGQFSVSPKTIRGTSEHSHSPVRHRASTGSDTDNVSRPRLSPTLTRSFNPNDPDVRERQRTMDADMAMHLSRARSNTLVVSSPISPSPPGKPVELDDPNFPRLSLQEEHSLKFARSGGHHTGADEHGEHYHHGLASEAHLNHLSAAHEPALLVSLGAQEQDDIGGLPLYQASVPLQEQPFDFSTLEAYAREEKRSLGIHSPTTPTPPDGGLPCSQSTTSTVPPLPDIMNANGSTDSNTIFPLPRARQRKLSQSAPRPRRGKMALFEHPSGGPPPTLAFRSPQLATSTTGQALSAVASADNLPSTNGTSGVPQLARQTTMGSGHDRPYRFSFYSNSLSATIHARSLSELPAEGQSFEELFQGMNEKGGRWEGAYLSRPGTSMGLAGPARGAPSIPIAERSGISKMSGNGKDNSHGYGPNNSAEANTWWLDVQSPTDDEMKLLSKVGEPVCDLRIPADSLRGVQHPSPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q284</accession>
    <name>A0A2R6Q284_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000414">
        <property type="protein sequence ID" value="PSS00608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q284"/>
    <dbReference type="STRING" id="98765.A0A2R6Q284"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS00608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="387" mass="41402" checksum="F4D96D758392970E" modified="2018-06-20" version="1">MSRQDKATTDKHAKMLRELVKRPENKVCADCKRNDPRWASWNLGVFVCIRCSGIHRSMGTHISKVKSVDLDVWTVDQMSSIQKWGNHRANLYWEAHLKAGHIPADHKMDSFIRSKYESRRWAMDGPPPSDPSVLENGETQEAPAPTPTITAPPSTSRPTHASSGSTSSLRSPVTRQPQPHQLLSASIAGRTTQTSQPIAALQQQQAPAPAPSVPAANADLFSLDFHNPTPPAGAQAQKKDMKQDILSLFSSSSTSAPVQPAFGQYGGAPAAPALNAWGQFSSAPPGAAVPPVQQTGMMGNAGTGMWGANSGWNATTAPALPNMWGSATAMPGQQPHLQQQPQQQNLLNTNDIWASSQSNGGGDLFGSSSTGMQKKDDVFGDIWGGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q292</accession>
    <name>A0A2R6Q292_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000406">
        <property type="protein sequence ID" value="PSS00861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q292"/>
    <dbReference type="OrthoDB" id="3232438at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS00861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="102934" checksum="8B1C83490099441B" modified="2018-06-20" version="1" fragment="single">GTMVFCTRCFGNFSRKGYTHHLSSSPACNLNSGDKSAAHALQYAMPFDDSEVHPMTVDEDDDGDDNMNLDNNLFSGDYFGNEYNAQDFGWEEGLEVEGVDSGRSDSSDDEPEGRDDMQDLGWEPPRLLSPSGSGLTQEEPGGTASHVTEADPTAHLRVEEALQQPIQRVSFPMTSAGKPIEDRGSDAAATAGYQLYETQLHLETDHDTSENMYAPFASKLDWQTARWAKLRGPGSTAFTDLLSIDGVPDKLGLSFKNSKELNALVDLLPAQRPRFQREEIVVAGEAYDVYFRDVVECIQALYGDPEFASHLVFLPERHYADPDHTMRLYHDMYTGKWWWAVQKSVEECTPGATIMPIIISSDKTQVTLFRNKAAYPVYITIGNLPKDIRSKPSQRGQILLGYLPTTKLEHISNKAARRRTLANLFHACMSAILLPLRRLGVEGMEMASGDGVVRRVHPIFAAYVGDYPEQVLVAGVKTGECPVCPVPRDELGEFATANSDGEDPPLRDIDRTLAVLATADESPVEFMRACSNAGIKPIYEPFWRHLPYADIYLSITPDVLHQLYQGVVKHLVSWIKAAYDPAELDARCRRMPPNHNVRLFTKGITSLSQLTGREHGDICRILLGLIIDMRLPNGLSSGPLVRAVRALMDFVYLAQYPIHSDESLSAMEDALQRFHDNKDTFIVLGIRTDFNLPKLHFLCHYLLFIYRFGTTDNFNTEYTERLHIDFAKEAYRASNRKDEYPQMTLWLERKEKVLRHERYIQWCENGRPPLHTINPIHSKRARHIHMSRYPSAKAVPFERLAERYGANNFRDCLARFITQHNHPGASRRELEELSALLPFAFRTVSVYHKARFWENTFSLYRHASDDYDVIHVTPSRLDKRGQEIPGRFDTALVNDGTGGSLGIKGKWSSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB89</accession>
    <name>A0A2R6QB89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB89"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="22782" checksum="2EA137C30C106183" modified="2018-06-20" version="1">MNAISKGVAIGIYDEGKQKGVEASKGGTQPYVDLMGRSPLYQTVETTWRALSSGTPVAPASAFSYITRSLKQTAPFIVGAMRLLAESYSPEDLNKLGFSLYTEFRPEVNEWGGRGEVRCETILSLRRVASTGSSSQRDEGRPQGMIKVEHHDNAAHEEIGEQDQQPAKRARVATNMTLEEYEAALDADDMFAKVDSNFPYLPDTKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBG2</accession>
    <name>A0A2R6QBG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBG2"/>
    <dbReference type="STRING" id="98765.A0A2R6QBG2"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS05455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="33407" checksum="E41AD303AB6492B2" modified="2018-06-20" version="1">MFWGTMADRWGRRPMFLACMLVLALACVGLALVPTNAYWLLMLLRCLQAAGSASTVALGAGVIADIAVRSERGSFFGLYSLGPMVGPCIGPVIGGILAGSLGWSFLPETLRSLVGDGSIRPHPFHRPLIPIIGRTISDSEAAVQEKPPKTPFTNPLRLFLSPVITLLLIFNAVLCAVFYGVTASISTLFVEAYPFLTEIEIGLCFLAIGGGMLFGSCFTGRILDKEYRKVKENLEQKCRDDFESTMKPEDVTKDENFRIEYARLRTMPIYYVLFVVACIAYGWCLDRKVNIAGPLILQILSKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEQ3</accession>
    <name>A0A2R6QEQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6QEQ3"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015352365" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="314"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS06631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="531" mass="55438" checksum="E92B738F1AF49CF4" modified="2018-06-20" version="1">MRLRVWLCGLLACTSQVVALGSSCSGALGSGSAASGDADVYTGGIAGPSWNCPSSDPEWYCPVNNFFKSVRNFVIDTTRVPPDQYGTGLHWQVGQATSLINVHVEMSTASGNKHQGIYMENGSGGFMADLSFNGGAFGMWISNQQFTIHNVVITNADTGIFQQWNWGFTFKNIQISGCRIGFGLNTGGLTEAGQTAGSIVILDSSISATTAAVQTSSDQSSSLGGSIVLQNVDLSGSPVGVVDGSNDQFLAGGGTVNQFVLGNVYSGDTKTYTYTHVAAPGPDLPPALLDPSSSNNGVFFRTRPQYQTYSADQFISAKANGVKCDGTTDDTTNLQNLINDYWGCKIIYLDAGTCKVTSTIVVPAGTIIVGEFWTTILASGSKFSDASNPVPVLQVGNPGDTGGVEISDIVVSTTAGSAGAICIEWNVKGEAGTLGTVGMWDVHVRIGGAIGTGIQVSQCPAGGSTTSTTCQGAFLGLHVKATGSGYFENVWVWTADHDLDDPNQGQIDSFNARGIFIDHAVGPVRVREPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIQ6</accession>
    <name>A0A2R6QIQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000328">
        <property type="protein sequence ID" value="PSS08893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIQ6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS08893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="8240" checksum="982DB77CF6FF4196" modified="2018-06-20" version="1">MTHIRRQEMGSVTLDQVVGKRREKPNRDRHGKGLDYCVVEVIRRMRNKGERPGCALQSENGHVVRNDNDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3Y0</accession>
    <name>A0A2R6R3Y0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3Y0"/>
    <dbReference type="STRING" id="98765.A0A2R6R3Y0"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS19931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7737" checksum="18A6007DD89876D0" modified="2018-06-20" version="1">MCLLASELRFFYQDGASHLFPEAWDDYLSPIPESERGDMILAYHAQLNSTDDETRLKAARAWTRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHR4</accession>
    <name>A0A2R6RHR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v2712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHR4"/>
    <dbReference type="STRING" id="98765.A0A2R6RHR4"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS29564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="992" mass="108604" checksum="88CC9669B7EDFB6C" modified="2018-06-20" version="1">MDKPTNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGSKAGDMRFTDTRDDEKERGITIKSTAISMYFEVDKEDVGAIKQKTEGNEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQALTERIKPVVVINKVDRALLELQVDKEELFQSFRRTIENVNVIISTYNDDVLGDVQVYPEKGTVAFGSGLHGWAFTLRQFATRYAKKFGVDKEKMMAKLWGDNFFNPATKKWSTKSADADGKQLERAFNMFVLDPIFRIFDAVMNFKKDAIGPMLEKLDVKLAQEERDLEGKALLKVVMRKFLPAGDSLLEMIVINLPSPATAQRYRVETLYEGPMDDETAIGIRDCDPKGPLCLYVSKMVPTSDKGRFYAFGRVFSGTVRAGPKIRIQGPNYVPGKKDDLFVKSIQRTILMMGRYVEPIEDCPSGNIVGLVGIDQFLLKSGTLTSSETAHNMKVMKFSVSPVVQVAVEVKNAADLPKLVEGLKRLSKSDPCVQAWISPSGEHIVAGAGELHLEICLKDLQEDHAGVPLKVSDPVVGYRETVKAESSIVALSKSQNKHNRLYVKAQPIEEELTLAIETGKVSARDDYKLRARLLADEFGWDVTDARKIWCFGPDTTGPNLLVDVTKGVQYLNEIKDSCVAAFQWATKEGVCCEENMRGVRLNVLDVTLHTDAIHRGGGQIIPTCRRVCYAACLLATPGLQEPVYMVEIQCPENAIGGIYSVLNKRRGQVFSEEQRPGTPMFTVKAYLPVMESFGFNGELRAATSGQAFPQLVFDHWELMTGSRNVQSGLGPSAFAAPYAFPTSAYKHYYNSPTAASAQPQPIISDPVSHVTYPLALTDPNSIPRVGIPFSVRENLLTPTTQNNTKDPHPLPPKASESLLLTQAVAQVLSISTNPVFGTDTCTRCQAALEVGKFLAMAAPEQGPAFAVAICDHFNFNSDCPTMFGLLGLGSVLTQVVANADVGGLDGQVCIPLLRGLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHU9</accession>
    <name>A0A2R6RHU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHU9"/>
    <dbReference type="STRING" id="98765.A0A2R6RHU9"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS29593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="517" mass="56533" checksum="1763ED1E8FA63682" modified="2018-06-20" version="1">MTLTLNLDNSAAESSTRRTLASLSLAVAKSKKIVVVTGAGISCSCGIPDFRSSDGLYALVKQQYPDVVLKGRDLFDASLFRDSTSTAVFYTFIAQLKQSIDKASPSPTHRFIKTLDSKRKLLRSYTQNIDGLEERAGLLGSASQNAKCTGKGKAKIRAKDVRNVQLHGDIHRVRCTFCSAEFPCIEEYVKSFDIGTAPDCPECTTRSAARQARSARALKVGTLRPAIVLYDEPHPLGDDIGSIQSTDITRKPDMLIIMGTSLKVHGFKKLVKDFAKTVRESAPPNYSPMKSPKGTKSWAGKVIFVNKSAPGSEWDGIIDYHVEGETDKWCEKVIEDWKKARPADWEVQTKLDATGGEEDFAGFKVMKEMTNATSAKPKAPKKAARENKPPAVEDIQPPKDTTTLSPPPSPSKRRNSGCHYSDGECSPSKKRASRGLEKLDFEGRGMLFGDATNIPDKEVDVEDVFGELVAEQVKGRPKSRAGGATMPRPAKQKVEVAMKLRESGRRTVAASRAARTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI19</accession>
    <name>A0A2R6RI19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI19"/>
    <dbReference type="STRING" id="98765.A0A2R6RI19"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="1">
        <location>
            <begin position="31"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="429" mass="45889" checksum="52FBEB45D71ABDDD" modified="2018-06-20" version="1">MLLPVLLLLRLVHAQCTAHNSLAFLSPVSSAPAITATAVFSNLSSPRGIVFDSHHNLLVVERGLGITAFTSSSPTCNGWLRTVVVQNANFTQGLQVHENSLYVSTSGEVWRYVYDPLSRTVHGGPQVVINGIPPDGELTTRPILLHPPTNPSTLLVSCSLASNIDLTARLPSSGRSQIRSFSLLAPPPQPFFTGTLLAYGIRNPAAFAFLPSTRLWVVDNGASIDNVTGLTAAFVNDNPADELNLVDLSDPAPPAEGRFYGFPDCTTIWNPDADPVGDPQYTGFERGAQFSLLLEPERGNAWCQDVKNNVPPRLSFQAHSVPLDLKFFFPTPTTTHSSQSLPHAWAGDAFVTFHGSFDRTPPTGYAVVRVPFSQSEPAATAGDTVLVQASDLATCPGTCIRPVGLAFSHDGRLFVSSDSSGELFVISAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIF6</accession>
    <name>A0A2R6RIF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIF6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="AntiFam" id="ANF00205">
        <property type="entry name" value="Shadow ORF (opposite nemA)"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11942" checksum="099BD8027AF28E08" modified="2018-06-20" version="1">MSTCIVTMIRTLKRTLKTSPWAEPDACPILPDLLRYCFQNLKRETTPVFDRAAVFICTLVGDILQKLIWEVAVRVMKLYAIETCAMDRVRRSSGKQLHVFFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLI5</accession>
    <name>A0A2R6RLI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000240">
        <property type="protein sequence ID" value="PSS30886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLI5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7218" checksum="C1485D1BC9847F0B" modified="2018-06-20" version="1">MGCPLIITFKNTCLGHGLRSRGLAAWPGSAYMSLEPSKAVLQGPAWPGLVGLGLAGLMALSWAWHITSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLU3</accession>
    <name>A0A2R6RLU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v2449</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000224">
        <property type="protein sequence ID" value="PSS31003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLU3"/>
    <dbReference type="STRING" id="98765.A0A2R6RLU3"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="74"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1133"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="249"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSS31003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1246" mass="139007" checksum="D1CFB6DB64095CC8" modified="2018-06-20" version="1">MASSDPPLGAIVDVAAGRGIVRFCGSTSFSNGKWIGVELLESNGKNDGTVQGIKYFTCKMPYGVFVRPSQVKVVNATPEPPPTAKGLVSRPSLGHQRTSSSTGAARVPSGSSRSSRDGSPAKPSPINILSSPGTSRTPSSPTKRTPPSALQSRGNHSRRTSLLSEAAGPTVVKQRSFDSSREQISGSSQLSQSPPTLHQPASSLPPSSLRRVSSPPPQPPLSPEPIHQLIDEREPGLSAPPPPPDDTELQELRAKIRVLEAKRADDARHVRELETRLNEAESFVALRPKLQAKLNSLQTELISTKRELADAQQLSHLSDNRIVDSQEQLEMAMLDKEMAEERAEAAEADLEEVKERLAIVEVELQVLREGGDDGNENVVKQSLAYIQLEKQNERLKEALIRLRDLSQETEQEQRKRIAEMEKDFIAIDDLQSQYESTQIKLANAEVQVEDLKLQLDDALGAEEMLVQLTERNLMLGEKIEEMRITIEDLEALKELNDELEENHMETEKALQEDLDASDLELREQARKIQVLEDACQDLEGTIVQFRELVMQLQTDLDALRAETQTAQHESATAASQTAAMMSLNLKLQSSATRNQSRAIELELRRIEAKESKELLAIVQPYLPQIYVESDTDATNCYLFFQRLASKIDLINHFVAQAQNLPDSLNGPVSEMLVGICEMRGRLSTLSITCQRFAAILRRCDVESFLNIGRVFLDISPMEKRIDMHISLLQREEFRVYECVSDAAKMQSQFDHLAETYFNHFDFDLGERELGYALSFDYDLEMFSASVGLIKTSVSAIMKDGDFELDMNGLNPEDDFFAPLQKLLDQCRGVKVLTKKLARRLEELTQDSAALKALLVPQLQALNNDVPELVNFGFSLAQQVMPYLSEVRSSKTAFKLAKVLSYVKDCAFSSVGKNNKDGLGSWDAVAAFFTKVAEDVNRLQPLTSENENIIKISGTAPWVVRIEDIKAATAINVEAERKVAQLNDELQALVRSLKAKDQNIQESSVKIELMERRMETVKKQADAINDLESELQKARKQERAYEEAMEQLQADLDALEQDNVKLKTAASSTERQAPTETQAAGPENIQVEGSLETSYLLEQIEALRGTVRFFRTENSYLKGQDLLREIEALPVLPRHVNREPTPPLVPSGGSDTSDSDSDDPSTPISLRTLTAESKLLYRDVIKYTSSPKVVDLSVVRKERAQEGGQRPWIPKKKTPAYQVWERKMEGERLGRRVKGLLERTSIMATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPN0</accession>
    <name>A0A2R6RPN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v2223</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS31981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RPN0"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1377"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1679"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1183"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1100"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1132"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1218"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1233"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1254"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1281"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS31981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1836" mass="206279" checksum="4491AAD70BD2E1B3" modified="2018-06-20" version="1">MDMDQSDALVLITGGHGFIGGHLARKLCELGYKIRVTDISPHSYFPTTPAGIQTVVGDLLDPTFCRRVVSGVQIVIHLAATMGGMGTIHTENDSIIYKENHSMTMNVVSASMDVGVQKFLYASSACVYPELLQSTGDRDVSLREEHTSSYPPSPQGLYGLEKLSSEHLLHCLAGNMKTYVARFHNVFGPHGSWIGGREKVPAALLRKVIAGQLLGQSPIPLEIWGDGFQRRSFCYVDDAIDGIIRLLQSDWHEPINIGSDRAVSIQDLAAIALQSSGVAPQKASLRYLPSRPVGVGSRNSNNELVQEKLGWSPQVRLETGMTRTAEWIKGEIDTLVAGLNDEERDSTLRYLQTSSIVHLKPPNHVIFAILLPITSRTSPSDHNAKPEDCLNNLTRFARSLLETTRGDTREPHARFCVRVYLAIDESDEFLWQGSVNRAETVLRREGITDVVSTMCNFPRGHVCSLWRATARRAWKDGCDYFVLMGDDVKLLDNGWMSAIDSTFRDFSRDNNVPRGFGCVAFTDISFPGMPTFPVVHRTHMDVFEGQVVPDVFINQDGDPFLFQLYRRFGCSAMVPLRLSNLIGGSVDARYEKQHALDWTFSTLGEATTVIESYLGSCSFDSRKLTIDIVIPCYRVNMKYLDQFLALRFTPRCSVMFIIIVDDPLSPNITELKEKYGRRPDVRIRVNQVNSGASASRNRGLRESSAEWVHFLDDDVEPKSDLLVELEKVIRAHPDAAGFVGNAQFPLADTVYTTAIHLAGVTYFWDIATKIKRDVPWGVTANLTARRNVKDGVVYDLTFPKTGGGEDIDYCRKKRRYSIDRGGQGFVAAPAVTVTHPYWNGGRRSYWRFYMWSKGDGALIKLYPSLVYLDDAPNSAELFLISFLWTAGSGAASHFVNTPRSVIIFGPCMAVAVFCANIFHDVYRHCYREADRTLAIKSDLVGYRWVLAVVESSFIRMFSEIGRVVGLLERRDLTLLGHRFDWFAGVLGEAPQREERKNSRQRITKTSVQSNTPETSDIEEGKVQKQRPSLRRSTRSSATTSKNKRPLESDNDENTKLEKAAEPPRKRRKAVFVDVPATKYSSDNLKVNKGKAPVKQRPTPEEDEIVPDSQEEGLEYDEQASIDESEGSGSEFEASDEDEFVEGSQEEDNINADIKLRAYAEALAEEGLDAEELIMDFAIQESLESSRNPHSRGQASSAAGSSSSKKPVRNAAAALRAAAAERRLQRSQNKDSDVSEEYAFDEDSDSGSSDDSQTRKKGKGKPKGKTATVIVKAKAKHMSLADLKKQRQEQRQRASERRREEAALRKKLGRKLTQAEKNALALRKHHPELRDVWGDVERAIPIVVPVRAEQPARLKATLLPFQQESLSWMKQQEKGIWKGGMLADEMGMGKTIQMIALLLSDHGAKPNLVIAPTVAVMQWRNEIEAHAEGMDVLVWHGQSRETDIKSLKKHDVVLTTYAVVESCFRKQQSGFKRKGMIVKEKSPVHQIVWNRIILDEAHNIKERSTNTAKAAFELQSSFKWCLSGTPLQNRVGELYSLIRFLGGDPFSFYFCKQCDCKSLHWRFKDKRTCDDCGHSPMQHTCFWNNEILTPIQKNGMVGPGVEAFKKLRILLDRMMLRRTKIQRADDLGLPPRIVVVRRDYFSPEEKELYLSLFSDAKRQFNTFVDSGTVLNTDVGEATVCRLCNDIAEDAIQAKCRHIFDRECIKQYLNTALEQTPDCPVCHIPLTIDLEAPALDLEENTKTRQGILGRLDLDKWRSSSKIEALIEELSNLRRQDATTKSIVFSQFVNFLDLIAYRLQKAGFSVSRFPDLEKANRLIFTHFTLLGMSFGGYYESSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPN9</accession>
    <name>A0A2R6RPN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS31993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPN9"/>
    <dbReference type="STRING" id="98765.A0A2R6RPN9"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS31993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="466" mass="50385" checksum="CCD506502A744A4B" modified="2018-06-20" version="1">MSMSTDRRHPASLVPRSQHDPALVDLMRSHVSNEMVAYIALQATRVINLGDESSDSALPTPPHTPHKASFSEQDRSQPRSPWLPSLQNFIIMLVKESNVQVPTLLTTLIYLERLRTKLPKMAKGMPCTRHRVFLATLIVAAKYLNDSSPKNKHWALFARLFEPAEINLMEKQLLFLLDYDLRFDESEAMAHFAPFMSRRLEFAKETRATAVTRAKARVQAQVSLPPTPPHDVVPTRIPSPEAPTFGVQSLVKRLSSTYLSISSGNPSARPRALSRASSSSTLGTASASGDSESGCLTSSSAYSSPATSISSASDCEIELKDDLAMNSTGDKFVLQAVPSHAVRQGRKVSTASTCTIKGDPTTGEKQPLSPSASIKRVGFEVDAKLGTSRGSSKRSTLQASGQAPSGGFLSRMFGSSNKLQASQDKDLSIIDLSDSVDAQGASSALRRLAQSKSTLFRGQPSQGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPW6</accession>
    <name>A0A2R6RPW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000199">
        <property type="protein sequence ID" value="PSS32078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPW6"/>
    <dbReference type="STRING" id="98765.A0A2R6RPW6"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22566" checksum="7A190BFC2C731E10" modified="2018-06-20" version="1">MAAVLHCAEIAKFVVDRAGPISPSTRNPIRSQGRRRSCSGIEVQESQHLYLVNAWEAPENHTIAPASNVEGARGEHSVDASASNLEYHIHVHFSEEPYTALSAPLTEIVLWTLKEGSPRAKVEELLTDLMTVVNGIPTSAGMHKAGWGPVLENEKQFVVLIGWENMEAFQTAVKNSPEGRAILDQLDQHTDRLLRHVILEHDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVJ9</accession>
    <name>A0A2R6RVJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVJ9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="13222" checksum="0380BF22946974F4" modified="2018-06-20" version="1">MRARPGWGTVLNTRVVIKPHGNSLRVRCQSLRTSLAIARFITVLNDVDRVLSSSSRCQVLCICPGTRGQILASISPQQPPFPHHSYTPMAPGQRVKFYTRRGRLGELLQTLRRTLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVQ5</accession>
    <name>A0A2R6RVQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000157">
        <property type="protein sequence ID" value="PSS34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVQ5"/>
    <dbReference type="OrthoDB" id="3232876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="418" mass="45557" checksum="97E0B4C2D0C9C61B" modified="2018-06-20" version="1">MLSADSDQREAPAPATRSSFGASLIEKLKVAIRDSLAAFTGHAISSQPSQLEDTRIKSDSNGAEPSVAIVELSSVEQRDRHKSVMASRYGIRVHDFAYESKLPPVPSYRPPIQVGPRTLKRTRRKYEQNSDADSEDFGVPFTPDLAPSSPRRVKKPKTSQRELAEPLVSSQSQQATGYEFPVQSMGIGCSTPHSGAHPTPSTPCRLAIQVPTSLFSQMLNSMDNFSTPPSQPSLDESSQETDPWVGTLFMTPNGSYQLKFKDTSAVPASQLSDVLPELPKTSGSFPQLGLIPRPLLSSPSPRRGLQRSLSRISGTSSPSRSSGSRQIVAPKSCFRENTRKFPSPSPSTSRAPSLTVSRYQLRNRAAVASLSRTSGKAHRESHAAAASPSRKHRWLLSKDMQAKSKPALRRSARKAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVV0</accession>
    <name>A0A2R6RVV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVV0"/>
    <dbReference type="STRING" id="98765.A0A2R6RVV0"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="250" mass="26995" checksum="D4DFC3528CC84C5C" modified="2018-06-20" version="1">MTILITGAAGRTSGYVIRTLLEGGTQPNVLCLFVRSEAAVEKLQAEYPQLPRCSFAIGDYLEPKSLSIAFQGVDIVFYNGPAFQSLETAMGIAAIEAAQRAAVKHFVYCSVLLPGLRKLSNHELKLGVEEYLAESGLNFTILQPTAYMQNFKVKDIVAKSVLAWGASTMIMKSFVDLQDLADIARLVILDPAPHNYDARYDVVGDRCSLEDVANTITCRAGLSGAVVCQQLLGVSADALQSDSALARLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZN8</accession>
    <name>A0A2R6RZN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZN8"/>
    <dbReference type="STRING" id="98765.A0A2R6RZN8"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="13994" checksum="8B559F9B764206B2" modified="2018-06-20" version="1">MVDSDAGRVTRGRNNEDEELDDDELFAQLEAELEDDMTGGTNRERALEEMKREFERNQKLRETGHGRYDEIQLEKTVLETSIFVGFEEFGNQDNFDTSVIEMKLLETGMIPCQALQVDVSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZQ5</accession>
    <name>A0A2R6RZQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxidase</fullName>
            <ecNumber evidence="5">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="4 5">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="4">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000125">
        <property type="protein sequence ID" value="PSS35496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZQ5"/>
    <dbReference type="STRING" id="98765.A0A2R6RZQ5"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal ligninase C-terminal" evidence="7">
        <location>
            <begin position="131"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS35496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="206" mass="21581" checksum="9C40067D05E62743" modified="2018-06-20" version="1" fragment="single">IQFAGAVGVANCLGAPQLPVFIATQPAPDKTVPEPFDTVDSILARFADAGNFTTQEVVWLLASHSIAAQDHVDPTIPGTPFDSTPEVFDTQFFVETQLRGTLFPGTGGNQGEVESPLLGEFRLQSDSESRLQTLFTAAFRKMTILGSSEADLIECSEVIGTPPSGDIPPAHLPAGLTMNDIEQACATTPFPSLSADPGPATSVAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZT9</accession>
    <name>A0A2R6RZT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000121">
        <property type="protein sequence ID" value="PSS35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZT9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7525" checksum="851028DAC933CB06" modified="2018-06-20" version="1">MDHACLCCSISVDIHRVELDEISATYTEVNVTVSYRYPDEGKVAAISHSISHGRIIANYDVMPGVSGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3B6</accession>
    <name>A0A2R6S3B6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3B6"/>
    <dbReference type="STRING" id="98765.A0A2R6S3B6"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053205">
        <property type="entry name" value="GHMP_kinase_L-arabinokinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134:SF2">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38134">
        <property type="entry name" value="SLR1395 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="56060" checksum="35D9EFE969DE0E15" modified="2018-06-20" version="1">MEEESQWLRRNRIDCVLSDAAFLGCVAANAVGIPSVLITNFTFDSVYSYLSTPFVDTVNPSELLQATKPALPPDISIPLSITEPLAEELRGSYRCADLLLRLPGAIPIPSFSEEPSLPSPSWIELESQIFTPDVHAHLRNPPSTYTLWPQIPFPPDYPQKKVPRSVIDVPLLVRSPNPSVFTSEGRRCLLDSIGVPRKIQDSSNTKILIVSFGGQVFHKPHSHSRSPSNSSSPGHSVLTPSKVINSAQQHPKINADLKHKLPSAAHESASGVEALSEALRSSLLNGAKTTPPRVVQNRPGQSVLIIPGAPPASIPNSPIATTAPVFSSIIVPATPKPDSAVEWSLDLAVKAEEEEAPYSMLPDDSWIAIVCGVPKDWAEKDGEDMPENFFVAPKDVYMPDLTAVADVLLGKLGYGTVSECIDACTPFVYVSRPLFVEEHGLRLLLEREGVGIELPREAYEAGDWASATLEAYNRGKERKQKKRVEGETGRRLIEGREMAMTLVHWVARWQSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3T9</accession>
    <name>A0A2R6S3T9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000091">
        <property type="protein sequence ID" value="PSS36932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3T9"/>
    <dbReference type="OrthoDB" id="2804425at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="351" mass="39576" checksum="30970A7C0C7B796D" modified="2018-06-20" version="1">MTHLFKGQPTIKPANNNNIIDNVTAENANATLDAAIAAKDVELDIAVPKQYSYWEGKMLDLQQGLMDDDRAIYLADLTIDICQRFEWVCFNKSSILCIKEVATAYHEEVKEYKKDPADNTPPDAPALAILCGVYCIDKEYFFMGPEKNWNPYKDFGGLEGSKATCLLSKAAESIFANDFYLQDKNVCTLVEMGHSDNGHKLNGIFVDSPDNHNLLKIHHVLFEVNVTPLHQSHLLTIAALYKLDEYEKIVTEEKLVANRANNLFITNEKSLEGWLVRRQQAKRAIKSMLTKYKVVALSAFEMMGAKIRSTKYNAALKGTNAQFHFMMAHWKIGKGDDRQLLADTCCGSDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4B6</accession>
    <name>A0A2R6S4B6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v1061</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="MLYV02000082">
        <property type="protein sequence ID" value="PSS37095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4B6"/>
    <dbReference type="STRING" id="98765.A0A2R6S4B6"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="16">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSS37095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="504" mass="54783" checksum="95FFF620A6CB1FD2" modified="2018-06-20" version="1">MFFCSISGEPPQDPVVSQKSGHVYERKLILKYITENGTDPITGEKLEESDLITVKANPKTAPPRPPTATSIPALLQTLQNEWDATMLEVYALKQQNNSLKQELSVSLYTQDAATRVVARLIRERDAAREALASVSATLGVAPAAAANGDVDMEDSEEAISLPEHIIAQIDETHEALSTTRKKRKAPADHVTQEQIKTFTAKHTVPSLHASSPAGITALAISQKNPSQFLTGGNDKVVQLYDRSTDKVLATLKGHTKKINHVAFREHDGHPTLLLSGGADKIAKAWSHDEASGEYIPKGTIRTHKGEITGLVVHPTKTILALTSTDRTYSLHDLTTFDQIYRSAESDEPYTSLAVHPDGTLLAVGTPASTIQIFDVRTGAIAAQLTPPEGVPFTVNTLSFSENGYHLLAPDSLSSVGIWDLRKPKLSHSIKLGDGFKTHKVLYDYSAQLLSVAGSEGVRLFAHKTWEELVRFEEAGEVVDLAFGENGKELWGVSGRDVRIWGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S604</accession>
    <name>A0A2R6S604_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S604"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="7627" checksum="E72623003BD0ECEC" modified="2018-06-20" version="1">MSSDIPEVETVVAPTIDSSESESTTAVVTSDVVTQEEGFRGKNVKLTAPAAKPPQGLQAPGTGQVKITARTDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S608</accession>
    <name>A0A2R6S608_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S608"/>
    <dbReference type="STRING" id="98765.A0A2R6S608"/>
    <dbReference type="OrthoDB" id="3204655at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="19113" checksum="B637B5022CCECEC1" modified="2018-06-20" version="1">MPLVVCLVRTHDKDLPSIPAQSLDVAALKCCATVEDEEGMVSVEVLDAEFFDENILVIVFRPSDRGRGPTYIATIDYTNLVYENIEPTLLPNGTREGLMSTVLQLLKDGQIVSAHLPILQSRALVGCREGNVTLAVNGRVGRRVACVLDDAGLALEILDMEGDADEDEEGMEIGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6A4</accession>
    <name>A0A2R6S6A4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6A4"/>
    <dbReference type="STRING" id="98765.A0A2R6S6A4"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="234" mass="26046" checksum="7808FCA48B87A74E" modified="2018-06-20" version="1">MASAYCFRETHAHADHLTSSQYLKSQLGGNVPVCIGARIAQVQNTFASVYGFDNPAFFQNTFDIYFEDDFEFALGGTTCRVMHLPGHTPDHIGYVLGGAIFTGDSIFNPDVGSARADFPGGSVTDLYSSIQRLLSFPEDSLLFVGHDYPAPGNRTPIPCTTVREQKDAWNKKDKTEFIEWRQQRDATLSAPRLLHPSLQVNIRAGKLPLKDESGRAWLKTPLRGVDRCWPNCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Y6</accession>
    <name>A0A2R6S6Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v85</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000006">
        <property type="protein sequence ID" value="PSS38070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Y6"/>
    <dbReference type="OrthoDB" id="2746812at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="100" mass="11287" checksum="561DDD59A004F675" modified="2018-06-20" version="1">MATHYANAKARYSRQLAEMDSPRYYTEFVCCGLPLHVALARGHVVGDRDARVCNVTGWQMVGGCGQVVSRRDVLYQHLKDTPSCLGDPRGNWFNRIKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDN0</accession>
    <name>A0A2R6NDN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDN0"/>
    <dbReference type="STRING" id="98765.A0A2R6NDN0"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="26504" checksum="DF016385D44F6054" modified="2018-06-20" version="1" fragment="single">MSLPLAGKVAVVTGSSRNIGAAIAKRLATDGASVVVNYVNNAAAADDIVDYINSEGNGKAIAIQGNMCVLDDANRLIEESVKAFGKLDILVLNAGMMNNHPLEGITEKQFDDHFNTNVKIPLFMTKTAAKYLTSGGRIFFFSSSTTKFSGIPSNYLLYTATKGAVEQMTRILAKDLGAKGITVNSIAPGPVDTDLFRSGKSEQLINFFKSLHPQKRIPSPDEISPIIAFLSREEAGWINGQTLYVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDW9</accession>
    <name>A0A2R6NDW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDW9"/>
    <dbReference type="STRING" id="98765.A0A2R6NDW9"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="111"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="471" mass="52540" checksum="0CD0D419B198EE21" modified="2018-06-20" version="1">MAETLSELKRPRSRSSSSSGSQSSEYPNDEFTGGLAVATASRLNTTTITTNGVAGSSRNSDRPSEPSRKRAKVYEEVERMLVHCPAPRSQADGYHDSARLVRDDTYYLQDGSCVLQVENTLFNVHRTLLGKDGSLFSSMFQLPQGEHEPEGTDACPIVLQGDTVAEFKHFLWVLYALPHELLEVTSPQIDLTRLSRLIDIARISFKYHFKSLETWALDVITDHVTRKPSPIFSVPTSRITATATNTATAAALASPSAIAANGALISRLMRLGQLCTHERLLTNVITVVRALMVYSVQYAHLAMTLADELNLRALRGIAYFAVMQQGDIVTRGSPNVPEDAIVDEDGRLIVSHQQKLRLLSGYHRLTMLWEHLRATPLKFDHALACGATWHQHGCSQCWLDFWKEKSKGESVLDLGLADVPGRLRAIEKEFARWGSATYMHNDCRLTVRKAIQDKIKLIEDALPDYFEDEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEA1</accession>
    <name>A0A2R6NEA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEA1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="5410" checksum="4A2B34419AD3535C" modified="2018-06-20" version="1">MSERAFASGLEISPHTVEYESLSGLKRFSPPGGGYTPGATVSGANPAGTITALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEL5</accession>
    <name>A0A2R6NEL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEL5"/>
    <dbReference type="STRING" id="98765.A0A2R6NEL5"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052527">
        <property type="entry name" value="Metal_cation-efflux_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847:SF1">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015342741" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="252" mass="28520" checksum="A4AF4D3F311C1BC4" modified="2018-06-20" version="1">MSIFSLVILKIPLLLVSSACDHVAFTAPNPSAQSEERAKYDVKTGASEKGSFHVVRAATTLRSFIHAVNLLELATIIRSIYHSEPQQCMKTFHGPHYIRDWSPSFVEPKIQISAQFLTGFTLMVLGASLRAISYRYLGKDFTFELAVRKEHKLVTTGPYYPVRHPSYTGAILFMAGAIISQMGHGSYWSECGLWHGAWGLILGLVYVALIPYVVVVIFLRMPNEDAILREEFKEDWDAWARRTPYRLIPFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEL8</accession>
    <name>A0A2R6NEL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEL8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="160" mass="18485" checksum="BFD1FAFACA1C8137" modified="2018-06-20" version="1">MDRDEERTTWLEETRQGLDSLMQVATSARDELAEIKETVNERCRREDVKNTSRDGRCREIQEQLAKIIAERQHGGAGLDQTSPSDDGATYYRSLQQLRLGQRENRAVLEAFMQGKYISLHPRLIIEQKEILRLTKGTPEFNAIQQQNHDQIMAAVRGMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEN4</accession>
    <name>A0A2R6NEN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEN4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="8799" checksum="9BE79C4A73A53F56" modified="2018-06-20" version="1">MPTYGNASRRCTCAGKLMEQIDKVSSLLPRPPSVPPSFFPLVCEKLLLETMPGVVTMCTPSLLAGSGILFRRLGGTGNSRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEW5</accession>
    <name>A0A2R6NEW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001302">
        <property type="protein sequence ID" value="PSR70927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEW5"/>
    <dbReference type="STRING" id="98765.A0A2R6NEW5"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="350" mass="39499" checksum="38C0F9CAFE8167AA" modified="2018-06-20" version="1">MSLKPMRQQVEEYIVGLQDTIVSALEKLDPNAPPFKRDSWIRTQGGRGQSCVFAVPEASESGSAHENLPVLEKAGVNISIVHGKLPPAAVKAMRVDHSSVPFDPLSPAVPFFAAGLSLVIHPRNPHAPTCHANYRYFEITESVQEGKESGSGKLLAWWFGGGSDLTPSYLYEEDAVHFHKTIKEACDTHGEAIYPAFKKWCDEYFLIPHREETRGIGGIFFDDLCDQTHHRLPDDAVRPRTPEDIFKFIKTAGDAFVPSYVPIVERRMKTPSTPHERRWQLIRRGRYVEFNLVHDRGTKFGLVTPGARIESILMSLPETARWEYMSDMGTDENSEEGKLMKVLKEPRAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF25</accession>
    <name>A0A2R6NF25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001342">
        <property type="protein sequence ID" value="PSR70622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF25"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6341" checksum="D95A7CEFD1B3E242" modified="2018-06-20" version="1">MPRRAYVEDAVPIWNEDRLERLQLFVRVRAEVPAPHFAMLLEVGAVALEQGLTAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG88</accession>
    <name>A0A2R6NG88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG88"/>
    <dbReference type="STRING" id="98765.A0A2R6NG88"/>
    <dbReference type="OrthoDB" id="2803091at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015348448" evidence="2">
        <location>
            <begin position="24"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="32945" checksum="BCE6FFFC1316B08C" modified="2018-06-20" version="1">MRSPVIAFGIFAAAAVSPSLVSAAPTSPNVPNVGDGVMGAPLNPLLTRVHAPTAGSVARRSQDHSGIPVPENAQALDSSQKKSKHHHSKRAYDAGTGGGNAYTGGSSDASGGTVVNETDNGDEELTNDTANTAGGAGDSETGDARGGRGRGRGPGGNGYTGEAGRAQGGSVVNEGGAVDNTAASNIGGDGAASESGNAFGGDAVKKRAMNVEGRTTDVKERAIGVKKRATDDRTGGGNAYTGNSGDTGSGNIINSADDESTITNTGPGTNTVPVSGTSTTGDAEGGRGDGKGPGGNAYSGFAGPTRGGEVVNSGGPIDNTGATNVGGDGADSVSGDAEGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGI0</accession>
    <name>A0A2R6NGI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGI0"/>
    <dbReference type="STRING" id="98765.A0A2R6NGI0"/>
    <dbReference type="OrthoDB" id="3208947at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="70934" checksum="7834B2D23BA1CC64" modified="2018-06-20" version="1">MYIASLPNPPTPSSLAEARREVTVQQASHSNLTTRIQAAEEELARVVEQSKRAIRELEKERAAIEQQLAQTLSYLSPIRRLPQELLGHIFMCIFDDLPCCAWILSAVSSLWRRQVLSMHKLWSKIRLVTSQSASAETVRLWLERSGSTVPLDIEIFLHSPAPGSGSTSGELSTIRRRSSSTGTLSVANGWDTWVDYPVPPSTPELMVSAPGYVHAYPPHFTGHGFHNTFGGMHHQDNVASSSANQQAQFEGSSPSGWRHSLQAPSRSTLHWGHIAFFYLTEQMHRWERFMFRYDRRFPSDEAMKSILGKAPLLREFEISCAEPGFLGIHHWKWLPSTTTTSTYELGNLTSLTLQYVPFKWSSPIFRNLQSLSLRSLPNSPHALDRILYMISSSPQLENLALYFSSVNPAVLPLSLTTLERVRVFSIGGHFLLTSLVDCLVLPSVETLVLEIDSREAVEDTLSGLLIRSNHPPVSRLSLSYNVATGPGGIVYTGGSMVNSWNFLGDIDQLRSLQVGASPLEPLMVALDAPEDEHDPWFCPNLVSLSLRACNAHPMDGLPKLVRMVEARNPDSAGGFVPLTIGGVTPAKLIQLELHDCPNLDLDSDVIRWLNGRIRDVACTEAAFDRCVYSLCSTHFSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGL3</accession>
    <name>A0A2R6NGL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGL3"/>
    <dbReference type="STRING" id="98765.A0A2R6NGL3"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="65"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="564" mass="61341" checksum="01FF673929B8788E" modified="2018-06-20" version="1">MFNFFSNPDHLAACEQKRQDILHKLTDYTPLYSKPLTDHDEEVLTYSLHELVSECGTKQLSPSAVLEAYGKRCLAAHAAINCLADLMFDEALATYSPGGPLSGVPVSLKDCVDIEGHDTTLGYSCNANRPVSVSAPIVRLLQDAGALLHVKTTVPTGLLSFETASDLFGETTNPYNPKFSPGGSTGGGAALLAYRGSMIEIATDLGGSTRFPPAACGLYGMKASAGRFPSYGCGTSVPGLEVIQLTSPIARSLDDLKEFWKRIIELRPWDYDHTCVSIPWRPVDFVLTGKPKWAVLWNDGLITPTPACTRALQSAVQALKQRGYEVVDFDGPSAVEGLKIGYPLAFADGGVSLVAPLRSSESINGAISLLVNISRLPLFIKNSVAAFMRWFSSPAGRNDVYADVLESIHPCTVSQERALIVRREEYRARWKKAMREQGIDFVLTVPHALPPMPRGGSGVATLISANYAFLYNVLDYAAGVVPVTFVDKDKDALPSNFQDTDMYRNLNDAERAVWSLYDASAMNGLPLAVQVVGGRFEEEKVLEGMKVLEAALRDTGRPFVQKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH35</accession>
    <name>A0A2R6NH35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001247">
        <property type="protein sequence ID" value="PSR71705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH35"/>
    <dbReference type="STRING" id="98765.A0A2R6NH35"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="179" mass="19934" checksum="9678F2DB6D8F3E6E" modified="2018-06-20" version="1">MEPQETSEVDSVLRDYASSIDLASANDPGKKTGALLFAVVGAKLSEGLNFTDDLARAVIIVGLPFANLASAELKERMSYVSRLEQRRLGETNGKAKATGMKDAGTELYENMCMNAVNQSRAIRHRGDWASLVLIDERYSSARIRNKLPTWIGKDIKVAETFGETMREMGRFYREKRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH86</accession>
    <name>A0A2R6NH86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH86"/>
    <dbReference type="OrthoDB" id="3268868at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="19738" checksum="19690F20ED035405" modified="2018-06-20" version="1">MSGYDERLLSINAPAPTREEKQGGYNVDLLSNETRAVRSSPELNPALNHSSRHGHAESALASKEVLDSYPTRQRTPWYRTTKWIIILVICAVVAIAAIVAGAVAGSVHKHHNVNSAAVSASVGSSTSSSAAPTGSDGGVVGGGAPLGTSTSSSPSGGDVPVAPASTSSSTTSQGGAIPPVNMVVPTAAPDLTGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHA5</accession>
    <name>A0A2R6NHA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001244">
        <property type="protein sequence ID" value="PSR71764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHA5"/>
    <dbReference type="STRING" id="98765.A0A2R6NHA5"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="869" mass="95820" checksum="E27C8712FE1F19B2" modified="2018-06-20" version="1">MTDYSVFAHSDFDPNDYANAVLAGETYPIQTGKSKPVKSTAFTSSSDSQDISVAISKLTFSIEDVEKQVRNVVTTHHEELLVQAAGVTDLEGSLTSVRGGLLELDNSLDKLRLKIRTPYQNLQSHVTRLERLHQASNILHRTSRFVILTRRLELQLAEMDKAEADFTSSSNAINAKEKTTQSRRSTDSLATLGEDDLDKERIISKAALSIAELMSLLEPPSHSSNSSVSDSATNADTVPLASVKAVATYLPYVESARQRVTSDMEQMVISGLRTLNQSLLASSLQTAHNLRILPELVQNLVSDLSDAVEGRIRYAFDLARIAKEVTAKDATASTQSSMMYKSRLRTEPTNVTVPQWTAALWGSLESLIEEMADCCIKVYTLEKVLILKKDPSTQVIFLDEAMKILENKPSSIFWASLGQSLEKHVRDAAKGSTFLQQTLSTGYPRLLRLFHSFFAKIAVQTDTIYTQSQQSPETVVVLRALSTFESLYLSRSSNRLNESVGQAFSGGPRSPPGLTEGTSVARTVANELDSAKFDPLLVQSVAKYALNSLEMLVSRVDSMISRERAAYNLVGPSATSQQVINGQLATCLHHCGSRLSKLHEEYPESVLNILNPGLTSIQNTFERIANPLLAAIRRDIGATIAKLHRMDFGIDSADPMAAMGGGASPYMKDVAEKLTFIKAEVLSQYNIPDIREWILPIVKYTIKTFVLHVSIVKPLSESGKLQLTSDMTELEFSLSAFMADKAQVKRGVNWESIGDEYRTLRAMRPLLFLDNSSLASSNCTAGLPPLIVLHHILVRSPISLPHTLHGWAEAEYVRWVNEHSEQEAWSLVEGDLIHWEKISEVEGTDTTPASEYIQLARMVLANAAASNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHM8</accession>
    <name>A0A2R6NHM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001281">
        <property type="protein sequence ID" value="PSR71492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHM8"/>
    <dbReference type="OrthoDB" id="2802139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="358" mass="40204" checksum="8924B90343846D9A" modified="2018-06-20" version="1">MTLEKLEDDISEGILGSGKLSQWRAEEAEWLTKVVNQETHKTLDNPYEPKKETRLTQKQALAEIGAAMLSSSVVSAGLLGVLEEGIGLQEARSIMLLELDVGANSDVSMKTLQDLRSNWERDVESWRGRDAIYLTPLVQEAVKALDERSRTTALQSGAERGSLEAFTNGAADPDSSDDEKANRPTSEPASESKRKRGMSGRKPEKARPAMASELLAMRIDLPSSLHPIIRKHPAMKAAVDMEMGLREHQATGYCQTVLRGGVHWFRCNALKTRWSEQSELLPEEMRRTVRFFEYHKAEWRNKAEAEDARDMPGNAAYARRQVHDYERFLDGCRRAFEDVPGVDVDVLIASPTNMYDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NII9</accession>
    <name>A0A2R6NII9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NII9"/>
    <dbReference type="STRING" id="98765.A0A2R6NII9"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="13332" checksum="8EFC24742DEF24E7" modified="2018-06-20" version="1">MAFTKPTGIEGIDKIVPGATFKVGDKDIEVDRLISEADYMSGKCFSSGVSVGQSDTPSVLRNSSSATKQFVPLRPKLLNGGFKAPSFVAGSSKMGAQPSAKSVSTPVRSGAEKTKAERESFWAVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ80</accession>
    <name>A0A2R6NJ80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v11688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001177">
        <property type="protein sequence ID" value="PSR72437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ80"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ80"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="8">
        <location>
            <begin position="66"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="9">
        <location>
            <begin position="161"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="10">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR72437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="36202" checksum="2D8863BC10666056" modified="2018-06-20" version="1">MTLEKADDMPEYWRARWSRARGVKMAVTIQASDAHRPSQHTFESDQVRGLVSQVIRTLKPTDRLTNVSIVRLKKGGKRYEIACYKNKVQEWRNGVETNIDDVLQIANVFVNVSKGELAKSQDLQKSFGTTNTNDIVKEILKKGEMQVGEKERDHDLSSLRREIATLVAEKCVDPATQRPYPVGVIDKVMTEVGFSVRQGKTAKSQVSECIRLLQAESTLPIQRARMRVRVTMPVKDGKRLREQIVEGAEKVEGDEMGQEEWEVVSLLYLTELKHYLITMDSQVMLIDPGQFRVMNELLQKECKGKGRIETMSFAATASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ91</accession>
    <name>A0A2R6NJ91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001177">
        <property type="protein sequence ID" value="PSR72440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ91"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="9550" checksum="BDA83FE3C8EA37EA" modified="2018-06-20" version="1">MGEDLDHGRDAQNHYIDDAIAGQIWTEAGGPFILSENNDFYHSQGVSVEDKESHMLIYRDVIMTGLSPHLGCTTDLLFEGLRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJB6</accession>
    <name>A0A2R6NJB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v11684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NJB6"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="8">
        <location>
            <begin position="424"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="672"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR72470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="833" mass="91731" checksum="F3B62023E3A92186" modified="2018-06-20" version="1">MAKKRKETPPSTTLHDFFGKSGSTSVKKAKLDSSTRRPLKTKQNTSFAVAPEDIIVIESDDDEPVASRMVISKPDSDIKFVDELPPKNSITGEARPSAAQKKNSRKIAKYENYAELKVENDSAEISKTSVVPVLLGVDDLELVQFGQPSALLLRSGTPQLRPPAEEFSFGSPVLLQSHTQLRPTSETSGFQVVQDDSDEDPNDLNLIPSEKQLAYSTPPIVLDKPQVDDAKPLVPPDEEWGTGDDELEFQDVIMEADDKMTIDVDIDLTVDTDDESSGERNTETCPICSMLLEGMEKLDIQEHVNNCIDSTAQLYSPNPCTRASDVSCSAGPSAKVLRPLSSFQPPRVVPGPPLPLNPALGKEKSDGVFSVLMSSHKENEAWKEASTVEDRNFRPTKANGGRRKAPFYKVLQGMPIAVDAFRYGSIPGVTAYFLTHAHSDHYTNLSANWKNGPIYCSEGTANLIVHMLGVDRKWVHALPMDIATVIPDTGGVSVTPIEANHCPGSCLFLFEGPQTVNAGDSAYRSGFVGSGKVFRYLHCGDFRASPQHVMHPAVKGKRIDHVYLDTTYLDPKYCFPPQSQVISACAELARRIVLGEPLKGDGKKNGRVDGWFSVQDRHKEKEVSKSGKILVVVGTYSIGKERIVKAIAKALQTKVYSDARKMAILRCQSDPELDALLTSDPLEAGVHLLPLGTIASDKLKIYLERWKGHFTKAIGFRPTGWTYAQPSGSDSMPSVDSVISRSQSGSFTHSHLNPMRNSTQTLQLYGVPYSEHSSFFELTCFALSLDWGRMIATVNVGSEASRGKMAKWVEKWEAERKRRGKAEVVKFRAPDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJD3</accession>
    <name>A0A2R6NJD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJD3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="15934" checksum="C08318F6E188EDF1" modified="2018-06-20" version="1">MDISVSSLSEQSTSREPVLPPLADLQSVLRRVQSDGAITQAGVFNALAPLLVFLALLILGIIALQPGSSAQRVLKAPNEHMHDILKGISVIFGGLIVGAGMFRALIWGIALGVEAILNSDVKRASDTQRCLTPKEQAVPNTTSALLSGIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJU2</accession>
    <name>A0A2R6NJU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001149">
        <property type="protein sequence ID" value="PSR72637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJU2"/>
    <dbReference type="OrthoDB" id="2803764at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="198" mass="22878" checksum="781DA2679958708B" modified="2018-06-20" version="1">MQIAIIAYNINELCIKERRADAEVIAMYHKKHPGTNVTPLLRTPFMTEENSEYSDDNRRQDAYKKAGLTDQDIANGVKVLEQISLSWRSKKLRNTYHELDFYHNQKIRKIDKPSAPSRPRADLGRFCDEPPKRRIFRFMLSSRWVQNNPGIPVQVKRGGSSGFSDDKYSTDEYFQSSSSESDGQNALKKATIEEQEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJV0</accession>
    <name>A0A2R6NJV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001146">
        <property type="protein sequence ID" value="PSR72650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJV0"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="164" mass="18602" checksum="6C638D8346A1AED2" modified="2018-06-20" version="1">MPKREFPTEVNVFIEEKDKSYGMKLTSTLPAINLHYSVFFFESDLRIVSYHQPGVALNMPAPSLEAKGVLSIGFGDGDNAPRTYSLREEQDFDIGFLKIFLSTFPLDLSHIVQKYPFETDGTRRQATARKDRVAERPVSLLWDTIVIPVKQQRRGRANLHGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKM8</accession>
    <name>A0A2R6NKM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Urease</fullName>
            <ecNumber evidence="3 11">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v11171</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a nutritional role via nitrogen acquisition in the environment. Contributes to the central nervous system invasion by enhancing yeast sequestration within microcapillary beds (such as within the brain) during hematogenous spread, thereby facilitating blood-to-brain invasion by C.neoformans. Affects fitness within the mammalian phagosome, promoting non-lytic exocytosis while delaying intracellular replication and thus reducing phagolysosomal membrane damage, events that could facilitate cryptococcal dissemination when transported inside macrophages. Urease activity is also associated with the regulation of key intracellular metabolic pathways, including melanin biosynthesis, polyamine biosynthesis, as well as intracellular levels of proline and reactive oxygen species.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="13">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKM8"/>
    <dbReference type="STRING" id="98765.A0A2R6NKM8"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0533">Nickel</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Urease" evidence="16">
        <location>
            <begin position="393"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14 15">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="12">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR72934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="833" mass="89664" checksum="9E9101AB92B41FC9" modified="2018-06-20" version="1">MKPVTDMYIKAGFLAQKRLARGLQLNQTEAVALIASQLQERIRDGKHSVADLMHHGKTLLGRRHVLPGVPVLLHSIQVEGTFVDGVFLVTVHDPICTELGNLEAALYGSFLPVPTDDLFPPVDVAEYSRKQAPGAVVVRDERIFINKGRERVQLTVVNKGNRPIQVGSHYHFIETNPALTFDRAKAYGKRLDIPAGTAVRFESDHPKTVTLCSIGGAKIISGGNRLATGTVGSLRIESVIDDLVQRGFGHLPEPGALEVSVDTDLGREAYAAMFGPTVGDRVRLGDTALWIEVERDETVYGDEIKFGGGKTIREGMGQATNRPASESLDLVITNALIVDWSGIYKADIGVKDGIIVGIGKAGNPDVMEGVHPKLVVGSSTEVIAGEKHIVTAGAVDAHVHYICPQQVTEALASGTTTMIGGGTGPSAGTNATTCTSSPFYMQHMLAATDSLPMNFAFTGKGNDSGPKALEDIVIAGAAGLKLHEDWGSTPSTITNCLDVGDQYDVQVNIHTDTLNESGFVESTIAAFGGRTIHTYHTEGAGGGHAPDIIVVCGLDNVLPSSTNPTRPYANNTLDEHVDMLMVCHHLDKRLLEDCKFTESRIRAETVAAEDVLHDIGAISMISSDSQAMGRVGEVVSRTWRTASKLREFRGPLESLGDTEGCDNGRVKRYISKYTVNPAITHGISHLVGQVAVGMLADLVLWKFENFGAKPEMVLKSGVIAWAQMGDANASIPTVQPFIGRPMWGSHPRSAALNSVSFVSEVSIASGTIASYGLAKRFEPVKNCRNVTKKDMKWNDATPRMQVDAESYEVRADGILVDIEPATRLPLSRYYNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKU7</accession>
    <name>A0A2R6NKU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NKU7"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="488"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1259"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1266"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1304" mass="143430" checksum="1B63C192FA5FB692" modified="2018-06-20" version="1">MLPKVANQILHHTSRAVAAVQNQTGHTIRNVLQLQSSSGPSSAAGNLSVRTGPSSSSSGRGSNGTGAGGAKYHSSSRFHSGNTGIGRAATLIDPSVSHTSDAGPFDDVDECTPTLPVTSQPARRRRAQSHSLSFSSQERDEQLGRIGVLKTVQLHARSRHAFAAPPLPITSEKSTPETESDLSEPLEDDLEHTDIDANKAWYLSLRDAQVRGDTTQVFEIIAKLRSSPTPSPALYNAALYSLSKIRNEGEPLHLILETYNEMIARSIVPNTRTYCLLIQVLSDRDLEISKAIRHIENRMWRRTSAGLDKSASQSGDEQRIAQLRSENNFGSSLTLFQAACLIPRIQFYAGVYTGLLRNCAFHGNVDAAIHVFSHFEKCINLKPTPDIFRYLIQTYANAGDLQGAKEVFEEFKKAGKANRFSLEQSKIDTPEGEEQLLDWQKSFILVWNEMIRTYFVCGQPADALGLLEQMMDTTAGVSFGPGDIPPPSSSTFTRVISGFCQSGDIKSALAWFDRLLLQSGNVVDVYQPVLAPTKPDAGAWSSIIEGLGANGMVEDMNRLLKISMSAGHSSLHPRDILYTARVNFRYLETHPEIENIHALETLELLQPIVIPLLQQLPELLTFDMETTRDIYHSFVNQYVRLGYVDGALEVAEMATKSVLSAVRAAEANGGSSNAQYRVKAVRDFIQTVTGLLVPDTVPVWSIKTAMRLATLSMQVGMAPSKAVSQHYLDVYSRSSPSDRDLLTSEEWALLLHANCELGESSSQDAPSGYVEVLVIFAEMARCGIELDSLDRILQRRLTDLLVSRHDKEQVLGTLRQLGPAFQSLLSALEQARVQSSESSSPPLAHATPTERAHIDQYHSKFVDEHHPQNRKVSALMAYKRFESGAQMGVYPSPEVIGRLINALGRLGEKEKVKALYATAQLVLASLEQDKHWQSIGWFQIEDHMIIALAHSGDIDAAHVHRARIIGQGGSPSADAYGALIQYVKDTTDDTSNAMALFNEAVTRGVAPNIYLYNTAISKLAKARKADHALELFQEMRTRGVSPTSVTYGAVIAACCRVGDVQSAEILFGEMTSQPNFKPRVPPYNTMMQLYTHTKPDREAVLKYYNALLQSRIKPTAHTYKLLIDAYGTIEPVDIDAMEDVFNRLLNDPSLAVQGTHWAALINAWGCVRKDLDKAIQIFDSIPDHPSTQQSGARLPDAVVFEALINVLVTLRRTDLIPVYTSKLSSYGIHMTAYIANLLIKGYATAGDIEQARQIFESLSDPPEGVAAPNNHAPHENATPSTNNGLANSPVYREIVIRLEDRCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL00</accession>
    <name>A0A2R6NL00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL00"/>
    <dbReference type="STRING" id="98765.A0A2R6NL00"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_uL29_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="14561" checksum="D5F333BD4EF04087" modified="2018-06-20" version="1">MPGKVKAYELQSKSKNDLTKQLTELKTELLTLRVQKIAGGSAAKLTRISTVRKSIARVMTVMNQKARQNLRELYKKKKYAPLDLRTKKTRAIRRRLTKHEESLKTLKQRKKDIHFPIRKYAVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL06</accession>
    <name>A0A2R6NL06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001142">
        <property type="protein sequence ID" value="PSR72672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL06"/>
    <dbReference type="STRING" id="98765.A0A2R6NL06"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="28034" checksum="E920F6F58EF99EAD" modified="2018-06-20" version="1">MFIQTETTPNDDSLKFIPGVAVMSDGTAEFLDTRSALKSPLAIRLMGIEGVTGVFYGPDFVTVSKDSENTWAVIKPEIYSILMEFFSSNQPLFRSEEDREAAGPQDTKILDTDSETVAMIKELLETRVRPAIMEDGGDIEYRGFTEDGTVQVKLKGSCRGCDSSTVTLKSGIERMLMHYIPEVKGVEQDWLLDLVEADEAFISGVLNQPVDPENYYAHLMGRTCIEAAKYGLYVVAVAMVNAIMVCITLEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLH8</accession>
    <name>A0A2R6NLH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NLH8"/>
    <dbReference type="OrthoDB" id="2504896at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="901"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1410"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1533"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1592"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="911"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1414"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1533"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1545"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1592"/>
            <end position="1609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1644" mass="177248" checksum="03769DBBD86BBE56" modified="2018-06-20" version="1">MANIDTLDLSEPTSKAEGANSAQEGKGVEGSSDKGVDEAAGQVSKSASPTRDASPALSSPGSGLVPLRGTPLNGSTPPANNAPTISMPHPKKFSHVDINKRFLGKNSATSSTSQTPSASGAMTAKLTADPQRSTTTGPGWSRPSSTSSSIAQTPSIATNPKPTPVPPPVTGGAVPQLVPIGKVIQPQLRASTETLGSIGRKDSTGKPAWTNAKASASLLGGSVQNDFPTAAEVAQVRSAKLQEKKEAAQAAAAQKEALAAEADAFRGVHLAPNAHHWDEDEGDDSNFLDEVIQFDDGRQYTISQQAEPHSPPHDQAQPLKGADGSSKPPTAQDRPVSKEERFADDFDRSWPRSKNSDQRAPPPHMSPSSASSHSMHSPQDPSRVLFNERSNRLEPYSTHPSNRFGAPRESYFPGKGGRSEYVSSPTEARNARDAPPHAQGVHLLQKQGQTSPDDTAPPRSRMFGDHPSHSPWQDNSRPRDRDSFRRDQPAPFMSRTTSQGFDQGRSRDQYNSPVSPSIASDRPRRLSNMGPPPLPPHSPGASETSKDGRQLPPHLSGTHAGPSMWRSGSSAERPRRLSAASSSGNILPSLSPVQQPSHSPVASHVSLSPHVTESPLQSSSTMPGVDIEEVRKAAMHSAAERARLRRQHEEEEREREKERARKKAAELEVRLKVTSEVKVMTSVEETAKRDQTEAEVMAIIEDAVQSVAASLPTETSLVVVPREPSKKVLTRTPFVREPSQTGLARSSPGSFVPVEVSSPALEVESWRAKPTAVKLTAHDASERVTKLPPPSLPLMEEVESFNMETDGNVEIVDFSDHGKLIGVHNTPAHEPRPSEKVQRPPRPVTTDFFFDDEGVLDTRPSIVKNDEGSWRRAASQPTVNEDSNVQSIPQLKEKPKLMITPAPHFAPPPAAFSSAPTSSEEAPSQTDHEAAGNGPTNHLPLRSPQMSTYREAPMSALTDTMARIKGALDGMHYRPEPPQKWLPPALRLRETNDERAVTRYEHIDHDDHTHREVFDVTTYAPPRSPKPAWNHFMVRLPRISKKVEPIAQKRVRMFATQPHVRADIYSFVPPIEGMNRRDFHINDIIFRRPSMINGQPKCIVALPRMHTAQPSSQRTFVPVVNLPSKAANAKTGSGGAFGRSRDADGISSWRRPPSSPLKTQQTVEGEIATLDTISRSPPPEASSNGHATPTSGPNPEAVSLTVSVPPIKSKSQPKIPEGSGVAFYRGSRISHNDSHSKPTVSFIVSSELEEETMLPRLSDPLNFSQTEALPSSSVVQMPSFTSALEKRSMSQTVSSSDDPIVEFRKGNRSPVQAAITPPSQTNSLPRGKSSRETPVKDRAPNPEHLKAVWSSTSNKPKSTPHNSLEAIADDLTVVPFSIQDAKLEGAEIPPSSSSSHPSRMSLHDVTRTFQQVPSASASSSSASLRTAPLPPVASPTQRPLTMPMPPPMMQAGMRPAYPGYPSPMMSSPSPTIVYSQAMSPSPIPRPMVVNGPSQYPQPIWMPVPQPNGPNPGGMMRPMTSPYGPQLMHYPPPAGAMPMYPPPPNAQSSTSPQPNGQGRPPGMVMSPSASQAQAAMYSASPVLMHAMPRMAMPPGSGYPTGTPGRGQPPRSAYDNMQGVMHPSPSYLPQGPYPAVPPSSFVRSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLW1</accession>
    <name>A0A2R6NLW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLW1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="14790" checksum="D80E2140845669E7" modified="2018-06-20" version="1">MKMRTLWSPPSCGRQTYRLGEYPGLLKTEITIIFDSAITLPEAPQTLVNKSFKADRTQHLLILPHVVQGLENATSEEPISLKGFGENVVNLTTILDPTKTTIIGVNISFTGNTSNPPFFLNETCTNVLLYPAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLX9</accession>
    <name>A0A2R6NLX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001094">
        <property type="protein sequence ID" value="PSR73271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLX9"/>
    <dbReference type="STRING" id="98765.A0A2R6NLX9"/>
    <dbReference type="OrthoDB" id="3268672at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="1">
        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="148" mass="16249" checksum="BE5F08C04892CB6F" modified="2018-06-20" version="1">MPAPTDVSTSTTYTPVQYDVDENKLSAISPEAFYGSLLDENKPSTIFCYLTDALFFHIDTHCDVPGLRGTGVIEPEKLVWMKKTMGMGDEAASVLSMNLLLLYKTARVPYHGITSSSGDNVPTLDRRAFLHLAVFEAQAAPNETFGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMI1</accession>
    <name>A0A2R6NMI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v10506</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMI1"/>
    <dbReference type="STRING" id="98765.A0A2R6NMI1"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="289"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="359"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="506"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR73587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="735" mass="80622" checksum="5B42F04BC328060A" modified="2018-06-20" version="1">MPRVASRDHVAAAPQPGGLGRPPSPVTAAFPAVPFAFLPALVVELAEADMAPRCEPLCHFGGRLYFTSFPHPAPRPESLNCASDEQENQPRIRASTQASTSATPDDDAKYYYFTIDDQMIYLSFFQDWGPLNLAMVYKACILIHELLQDRDLSSYRLVLYSSSDPRRKANAALLMALFVMIVQQRPPWEAFHPIAELEFMPFRDAGRGRSDFNLNIQDCLWGIYKAMQNGLCDMNEFDVEDYEYYEKVENGDWNWLTPNFIAFASPVDPVWIKRERERKNQEAQALGGPPSPIKGEHALQRKLPAPFQNCLEYFEKKNIKLVVRLNNPLYDRQVFLDHGINHAELYFDDGTNPTDDIVRKFIDMADDVIESGGVVAVHCKAGLGRTGTLIGAYLTWKYGFTASEAIAFMRIVRPGSVVGPQQQYMYVKQLEWSKWAAVDEMRKIQAATIIARATLVTPATPPAEEDEDENMVAEVTATMTASIPIVIPSTPPPAIALPPVTPSRHVAAAAARAKAISPPGQPRKTPAGKRRSTALDSSEEDEADDILPSLTVAPSARRTKAKPASSRPTTGRGVTASEQRPTRLTRSTAAAATRKVGNVVAGTNAPSMALDTNGQSPNKIPRLANGTTARGTATAAKDTSMTAGRRLRNAPSPTPSRLPTLIPTRRGNHQSTTSVQEASSIAAAVKAAHASDWMTNNASAVVVPKSSPIQYYIRNIIDPAFAMPKYIPSWLAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMQ0</accession>
    <name>A0A2R6NMQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMQ0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7079" checksum="2022C8EA7DAA9770" modified="2018-06-20" version="1">MPCFHPHIEETSYYNTVQYSLDPFGHSQSEIIFRPFGYVPTEVRKLGAYTLLGGKDIKVGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMX9</accession>
    <name>A0A2R6NMX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMX9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6364" checksum="0E226E181165EFF4" modified="2018-06-20" version="1">MEQVLSRIYLAGLGSCSHRPTGGGSRAGHVEHIQEHEIRHPRYTKPRFPEYYASSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNF9</accession>
    <name>A0A2R6NNF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001045">
        <property type="protein sequence ID" value="PSR73950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNF9"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="10286" checksum="87035F3C73C32C2A" modified="2018-06-20" version="1">MPPRVRADLRNTIQIEPLQVKVAQSDDGPLYGTRLSTVILVRRDGKVLFVERDIWVLGEENKAFKAANTNDRVFTFHLEPYLSEDKAASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNL6</accession>
    <name>A0A2R6NNL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNL6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6256" checksum="94E2A705A227857A" modified="2018-06-20" version="1">MSSETLPSFPVNAPPTYVANPHPGWSIGQKTESIPDGTEWTEGEEAGWTVMHTGTEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNX2</accession>
    <name>A0A2R6NNX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NNX2"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000157">
        <property type="entry name" value="Alpha-1,3-glucan synthase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000114">
        <property type="entry name" value="Cell wall alpha-1,3-glucan synthase ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015362140" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1924"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1959"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1985"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2024"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2054"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2086"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2169"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2273"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2321"/>
            <end position="2340"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="65"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1641"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1867"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1666"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1875"/>
            <end position="1891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR74127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2360" mass="263325" checksum="70931576D3A97D28" modified="2018-06-20" version="1">MRLFSTAVSLLSLLSLTRASPYRDDLTDYNINTNQNAQTPLDYSTPKRANYTISPPNWREIPFYTLLLDKFADGDPTNNDYFGTMYEADWKETQLRYGGDLKGFVSKLDYLQGMGIRGIFISGTPFINMLWQADSYSPLDFTVLDPHWGTLSDWQAVIDEIHARGMYVMADFTVGTMADLVGFQGYLNTSAPFDLNEHNGVWKHPTYIPWSFDEYKDFVIDNTWNTSCQLPPLWINDGTVEDPGWGGGCKQSDFDQYGDMEAFGVHPDWQRQLSKFASVQDRLREWRPSVMAKLKVFACMTITALDIDAIRIDKATQVTVDALADWASSARACAASLGKTNFYIPGEVTGGDTFGALYYGRGRTPTMLPPGFLAAANLTANENQFFLREAPLNGLDGVAFHYSIYRSLTRFLGMDGNLQVAYDVDVNFITAWNQMFVNNDFLNPSSGDVDPRHMFGTSNFDVFRWPSLENGTQRSVLGTFITTLVMPGIPLLYYGEEQNFYLFDTSASNYLYGRQAMISNNAWQRHGCYTLGSDQYFNMALGKSLLGCQDDWNSLDHFDPTTDSRRIFKHFNYLRTAYNALQDGFNLVQRGNWTYFIDRPGSNGTATEMGLWSVSRSGIAGSQVLTGNDTDQVWLLYSNENTTRTFAYDCMDPKLWISSPFQAGGTVRNLLAPYETYPLAESGSSYNNDTKPPYFGCLASITLQPYDFKALVPSERWVGPQAMITKFLPGHDARIQAEAGDTNATTVDISLEFNMAMDCDSITSSISFNMSSSGKGSAPTIQQGSVNCTTVANPDTVYVNGADASAFSWSATLVNFPDGILEIIVDHPLSAAGGSTNAKDHLLLRKGSSQNPMVFPLADYNNAAFGYSGGHYTYTHNAFGADKFRYSWNFGQNWTQWQNWEDTTTLDASLFDSPSNFWTGQHVMVQYWSGIAMSAAVVVHADRGYSKPRRVPQLLARGPFNQWGFDQGIPAQMDHNDEGKWELEIMATWPTYVQLNVWGYDDYYYGDVDNDGILDRLPPNTAAPNYLNMSAPPHPHLAWALLVDDSTMSWSLEPRGQSAVGAIMYALLLSIPLITGTLAVLIFMWSFYGIRYNKWGVKPNKDHSSYFPILGALGHKSSSNLNKEHTPMSEKVFGHHHKNVDVIGWPEDKNKRRKVLIATLEYEIIDWKLKVKIGGLGVMSSLMGKAMTDVDLVWVIPKVKDIEYPQGDPAEPIEVIIFGEPYLIEVETHVLDNITYVILDSPVFRAQTKADPYPARMDDLSSAIFYSTWNQAIAATVRRNPLIDIYHVNDYHGALAPIYLLPKVLPVCLSLHNAEFQGLWPLRTKEEMKEVCSAFNISKEHCTKYVQFGNTFNLLHAAASFISVHQKSIGVAGVSDKYGKRSWARYPALWTLKHVDSLPNPDPTDIAALDEKPVAVRDIQIDQIAEAERPEHKRQAQEWAGIKQDPNADLFVFVGRWSKQKGVDLIADVMPSLLDKRPSIQLITVGPVIDLYGRFAAEKLSRLMELYPDRVFSKPEFTALPPYLFSGADFALIPSRDEPFGLVAVEFGRKGALGVGSRLGGLGLMPGWWFPVESMSTEHMMSQLTKTIKMALKSTEEERAMLRARSAVQRFPVVEWRQRMEDFHRRSINISRSIAASNAFRESDCDGGSGSAIPEHDDWNPEYQVHPSQPNWDAQSINESPRTPGPPGSPGQWSQDTMTPGPDQLHAPPRLLPDGRRGSFSTDVSDNEGDYFTENRGSTDTRQEFGNFLERANRTIAKDQKHMPDPFLDAAPTRPFGAHSRVSSVESIASIVDEKANSPLNKAIASFTDSDGGVAQDFVQKLQMLNAHNSKHELSIEKFLTKSEEKFFDKVKKDKLSSAASVRSSQRDSVWGTPAPSSFDHSRPSSPSNSAFAPGVDGYSGPLPNESGDVVVMTRLQIAMSRELFGWPLYTIVIAAGQMLSATSFQITLLSGQNWQTDLQLYVLGGVFLAASAVWYILFRYKPSVYVLAAPWLFFGIAFFLIGLPSVATALHPAHDALTSAATWAYAVASAAAFIFFGLNFGEEAGAATEVWTMRACVVQGSQQIWVAALWYWGNELNGAAANSNPPWWIVLVVWPLGVISALFAYLMLYGLPDYYRQTPPKVPNFLRTLFRRKLVIWFLGSEILRDYWLSGPYGRNWGFLWAVPIPKWQILLLVIGFFIGVWALMLGVLTHFSKTHTWLLPVFAVGLGAPRWCQMLWGTSSLALYIPWAGHAGPYLGISLWLWLGVLDAVQGVGLGMILLQTLSRLHVCATLAFAQIIGSVCVMVARATAPNKVGPESVFPDAAKWDFSDGLKGSPMASAPFWVAMICQIIIVIGYFWFYRKEQLDCVMHSTQTIPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP37</accession>
    <name>A0A2R6NP37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001013">
        <property type="protein sequence ID" value="PSR74203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP37"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="426" mass="47736" checksum="D1C93C4D7A17A2AE" modified="2018-06-20" version="1">MPPKRHDIRITRQNEIAELLFTAPQPFLGDQVHAQWLQHIAEQIHEYRKIDPRLESRTVRHVISQLRSMVKPFVGKPWLDAAIITLPLLNPQAPANYDDLVNDDVDPGATIAPSRQSTPSSPPPGIRRPRQGPLRLRSDSMSDVHEEQTRRHLNDDQPNKRRKIGTPAVADETTSNPTQNTDVLDAALITPRPQTVEDAPPNIAAAAVHDKSHGITSEAISTNDDTHFDMSAAPPQSASHAFTRHGQDHAPTTSGPHLDIAGTHREQLDRSVWPYNMIPTEPTRKSQRKKKLTTAAPHGLHPRASKNTKTSEPQANAPPPTRATTPIPTPQSRTMPNPAFNQQITQLETLPIYEHGSLRFDGIDTIGLPTHVVRDIRVTRDIMDDMGLRIHTMQVMRNALYDRQIKLLRDNGADPDKYPYQSHYPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP75</accession>
    <name>A0A2R6NP75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP75"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5585" checksum="6962D306694D4E7B" modified="2018-06-20" version="1">MSLSDGTICMTYKGVWLALSLALIYWEDSAEEQQPNLTKTTTYIGATCHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQA1</accession>
    <name>A0A2R6NQA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQA1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQA1"/>
    <dbReference type="OrthoDB" id="3268221at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="239"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="780" mass="85454" checksum="1511FC9703C365E2" modified="2018-06-20" version="1">MSTTSLLGQLAEREGAEYPFPTVGDHTLQRPESLSTGSSDSDFTPPYLARSLPSHHSSSSRHRHRTRNDRPHRARNEDEDGNGDNASTKLLSQLVSRSNLRDVKQVRTLLILTNDRLEAETRRADQAEQRVVDALHRLRSANEATALAQADASRAQQQVRLYELQIQQAQSEINRAQEIVNEVERARRDAEEEAARARSVARKCKEQYVSAKAREEGRQEGYLEGLARGRTLGFSEAQGARVVSRQGGRKVILQNEDEDDESEESEEPEEPRVEARKVEQRRSRQSPVPASVPWVHRISPPPPAERYMPPPDSIQPSRHTSPEHPSDVAPFTSTLPFPTLITPLHAPSPSHIRPSPQTKHQPPPQTRIHSSSPSHTPVRPSISGSPRPLPVPVPRRTPEQDPVPIVVHNIPPSPSHPRVDVPPDGWIPYAANNDSSTILIPPPHELSGAVSPVDPSPTRSEAPLPVPNQVPYSVPGPSGSYRSNDVQPPQYASSVQSRDYAFGGAPLPIKPPSTGMNSPQSTRPSTMSQYDLLVPPPNQERIYRQGVDRQSIMAGSGPADEPPRPVRMHARQENTESHDDGRSPLGKIFRNRFKAKRAPSSAQTVPQITVESPSTETVSRPSTVMTTTEPHLLSPDQAHKILPTLTDILGSQSHPHSPNPLPIPPKPIASGDIQSPGTAPIYHSTAPGSRSYSPYITAPVPSNIVYPDPPGRPKSRSSRASSSRVPVPPSFSDETLGSGSYRSRKRQDSVTDSLGTLGGRLSPLSLPFGQQFSSFTIPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQJ0</accession>
    <name>A0A2R6NQJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase AflY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQJ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NQJ0"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="55235" checksum="A980154A7BBA8789" modified="2018-06-20" version="1">MDATPAELNLLFPTPAPPPRSSVSPIRHSGWSADSTQALLTALKENHQRWHIFFNDQKFHNHASHHLLAIYALGASAETLNAAYETHVVYQRPSFKSPGAIDKSNWKDHLGKDEYYQAYLAFFSSELLAKGTQAVLEEYVFSKDANVVPSKEGKAPVMLSRYLGGFVHPLIHTGYGAEFGMPGMVAEGIAQAAGQEGDAIALFPAELFESPQSVSSMTSRLASFALSAKPSKPTSGGPHALTILGKIHNDISMAPDVIGLVAYEGIGNPLEHVERVVDSVGDKIKKYASEWTVSPTKEDLEAKLEEVIWMNTVIYAIGGYAGREQGHDEKKKFNGDFFLMHLVTSGLLVPSLLETLSPNTAVLLLRTYFTVALVLYVARGRPALPILDFYKSTTSMPTAPGTDPSPAPKTLPPATAPNPWLHILQTTLVHPDEHLCKTQRALAHSAELYGGASAGQFAHASKDLEGAELLDGTLFVRAASLTADRLGWMREGEEQRSWDHIGFFRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQU4</accession>
    <name>A0A2R6NQU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQU4"/>
    <dbReference type="STRING" id="98765.A0A2R6NQU4"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="713" mass="79105" checksum="70EBC665A36549C1" modified="2018-06-20" version="1">MASQAGQDAKFFQRGKIQEFRAELHAAESKDKKFVKRKTVLKKIVANITMGNDMSPLFTDVVQCLGIPLLEIKKMVYLFLVCYGRSKAEQIHLVIPSFLQDCNDRNPLVRALAIRTMSYIPIPVVTESLTEQLRHCLKDRDPYVRKTAAICVAKLYTADPRKAEKGGFVEMLRDLLLDANATVVSNAVAALSEIGDRQDGVIFKLNLTVANKLLAALSESSEWGQIYILDSLLRYVPERHSDAELMAERVIVQLGHANSAVVLTAIKVLLYLMNYMENRRLMDYICKKMGPPLVTILSSGPEVQYVALRNILLIIQRRPNVLKNDVKVFFCKYNDPIYVKLAKLEIMYRLAREENAREVLAELQEYASEVDVDFVRKAVRSIGRLAIKVEAAADDCIKALLDLIETKVTYVVQEAVIVIKDVFRRYPGKYEGIIPVLCENFDALDEPESKAAMIWIVGQFADRIDNADELMDDLTFTFMDEPVEVQLALLSASVKLFVYKSQSETSKALVHKVLKWATEEVDNPDLRDRGFMYWRMLAINPAVAGEIVLAEKPAITTDSDRMDRGALDQLLLHTGTLGSIYHKNPETFIRNAGGKALADSPALNPLSRQVLVPIARSNLPTAVQIPGPGPPEPPKDAPEALGVKPILPIHGGSGSDSDLIDASSSGDHNGDEDNDEDYIASPSGAGDPYANLGGAFGGYTTDEPKPHTDDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR68</accession>
    <name>A0A2R6NR68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000925">
        <property type="protein sequence ID" value="PSR75127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR68"/>
    <dbReference type="STRING" id="98765.A0A2R6NR68"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="813"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR75127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="853" mass="95354" checksum="0A25079A4830F315" modified="2018-06-20" version="1">MEQAQVSPQSPPPAVSLTSPTDSGKASTKPPVVRGARACTVCRTAKMKCVGAEDGQPCQRCKRSGSDCVFEKHRRGRKPGSKLSEASKMLRRLEKGLNTAKLKSRNDESITLPFPPDTRSGDRFPNNELPPLNLPPDYDNKFPTIGNGPRSSHDDEDTDDPEKPGDLFPAELIQKERNSSFFKTILNPTPCEPTSSRAVSERSSTLASPRTRTPILPPSHPPPSTVVTVPGLNDPIAAGLIDESRAAVLFDLFYLRLNPFINLFDPQLHTVSYIRSRCPFLFTTIIMGCCKFFEMDLYKQVQQLAHQFAVRAFADNWKRVEVCQAFACLTYWKEPEDTRTWTYVGYACRMAVELGLNRYVGKRPPEETNRQMLERRNRERTYLVIFVHDRSLSTQTGRQWMLPECELVRHSTTWHEEGDTPIRPEDVILAAFVQLRLIASETTEVFYSHRGVAGANHADMNHDVLLKNCNGKLTQWSENWEHEMQRANGDKFHFAFLSFFRLYVRLFLNSFGIQAYMSPTNRSSPSLHALSACYCSALEVLQIVTKEFAAMSMLRYGQDSITVMTAYSAVFLLKLLRSSNTLAELYEGATDEIYTHISQVAEAYHEASLLSPSSTAAAHHARFLRHLVAHDRPRAKQHEKDRYQQQQQGLRASDSRAQLHPQPMMQSQLEEHNFHFPASPTVPSPPLNHGSTLFAARSHGHAAMRDTEYASTSATTMRNGPMSGYPAYAAHAPLSQPPQGPSQVYGTTHSLSTSESDANYWRNMFRELGYGDTGDSAYSAVNGFATTMPDGGTFSVTTSGTVGYHDIPVNGHHVGYPGHSTQASHSSRQYQPYPTPSYNSHPSQSGYSTLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRC4</accession>
    <name>A0A2R6NRC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v9251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000917">
        <property type="protein sequence ID" value="PSR75210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRC4"/>
    <dbReference type="STRING" id="98765.A0A2R6NRC4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR75210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34812" checksum="5969C87B01653B24" modified="2018-06-20" version="1">MPPGPPGLPLLGNVFELPSKEMWKTFNEWNKRYDRRSAIYADRPRFVMANEVLCGGINLGFMTYGNLWRKYRRALHEIFNIHAVSSFVPMQSRESMLLISTILDDPANWEHHIQRFSASAVLRATYGWSLFGSSSDRDQTLQKIISLNGTLSKAAVPSNYLVNIFPALIYVPRWFPGAEWKRKGLEAHKTFDNLFMGLVDDVCVRVTTSTLCAMVLAMTLYPDVLRLAHDELDSVVGRDRAPTFEDKPNLPYIDAIVKEVLRWRPVIPLGIPRRCTQDDWYHGYRIPKGALMTSFSSVSDLNPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRD6</accession>
    <name>A0A2R6NRD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000908">
        <property type="protein sequence ID" value="PSR75287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRD6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRD6"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="486" mass="50984" checksum="E32716EB50316951" modified="2018-06-20" version="1">MAMTISAASPASPAPQSPSADGPATPVSPANSVQTLALPPPVDGTPAPASTIPPAPVPPAAKRKPSRRANTAERRATHNAVERARRETLNGRFLDLAALLPNLSQIRRPSKSSIVNSSIAHIHASRRHRHMAARELRLIKLEADALRRELNEWRDRSGLPRVEEPVRGEGFQMIMSGEVEILSAGPIEEEDGDEYGDGGYGDDDYNGNVPVVSSMGDDNEDMRHGNPMSHAAAASLLKAEAAGPFAHTAPNHGLHLQTILPRPANGAPSPMIVQSPTSVSFENPAMASMYEPPHAQQQFMMGGNVFSRMDESKWQMYGQQQQQFTPPASSHGIMPTQQQQYMHLNFQRQQAMMQSSGHHGHIYGSPIDNDDASSVGSAAGHSPVPGGAMNAGNGTKRERSGSMGSVGSAGSGHGNYEMSNVMAGGAGVPRRMGTGAWDEGMSMGGGMGQMGQMGPMGGMGMAGRGAPTAISVGGGGNAQGFAAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSK7</accession>
    <name>A0A2R6NSK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="4">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSK7"/>
    <dbReference type="STRING" id="98765.A0A2R6NSK7"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4 5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="266" mass="27491" checksum="5344EFA089C4CB9F" modified="2018-06-20" version="1">MVGGVSPKKAGQTHLGLPVFGSVKEAVREVRPDATVLYVPPPTAADAIIEAIENEIGLIVCITEGIPQQDEIRVMNALRSQSKSRLVGPNCPGIINPLGCKMGIQPGHIHKPGKIGIVSRSGTLTYEAVAQTTDVGLGQSLCVGIGGDPFPGTKHIDVIKLFLNDPNTEGIVMIGEIGGSMEEEAAEYLEKYNKTRSHPKPVVGFIAGRTAPPGRRMGHAGAIISGGKGAASDKVAALEKAGAIVTNSPAQIGPTMLKAMQAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSW2</accession>
    <name>A0A2R6NSW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000870">
        <property type="protein sequence ID" value="PSR75974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSW2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="11775" checksum="24E6C4EBC632D16B" modified="2018-06-20" version="1">MLLDEKLKLLEEVTAALNKEQSTNGRYIPSSNRALVSALPFGKSKATRYSSVPPSIPEGGSDHDIEMADGHEDPIEVMPTEEEDNIVEISPCRVRACARAMALYATVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUB0</accession>
    <name>A0A2R6NUB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000843">
        <property type="protein sequence ID" value="PSR76464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUB0"/>
    <dbReference type="STRING" id="98765.A0A2R6NUB0"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46238" checksum="AE88B9BD8FD0ABD9" modified="2018-06-20" version="1">MENSTTDASPSRTNIHTPVPTPSSNIHRSLGSEGHPHFSAQSSHTTRPLPFVHPTHAEFVQHPSDSSSSQTSSSTSNPAAKWSSRASRKNRYSAEPIHIHRQHEERVDEKPLTHHSSLVQIKQRVRHQNTRMKAHFTWDISFWVAVAFVLGSSAWIVNGFLLYLPLAPTASPDHTSAAAAMAFLGGTLFEIGGYLMYVESLNTGHDELFGREILGLLEGKNGHDRSRDQQKLVGHDEDSEKALQGGKRRFRWIGLGSWHDLGFLACFIQWMAASIFWISTLTGLPGIIPNLSTGPPTAIADVFFWTPQVIGGTGFIIASILLMLEEQRKWWLLNLKSLGWHIAVWNLVGALGFTLCGALGYAAIVSTKANYQSVMSTFWGSFAFMIGSVIQQWETLWREDPDANLNSDSDNDKNATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUE5</accession>
    <name>A0A2R6NUE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUE5"/>
    <dbReference type="STRING" id="98765.A0A2R6NUE5"/>
    <dbReference type="OrthoDB" id="3250110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="356" mass="38293" checksum="E63643EF5AFF48E4" modified="2018-06-20" version="1">MSVIVEAFRIKPFDLEPIYDTWPSAPIFQGNLSRDLPVDEWLQLIKDGAKQRRVPKEYWHKVAQHYLGPRAKARFDELKAVMKNMHGGRYSWNWKRFKVAMRNMGWDIDPTKTEEIKVQSKPSGLWWIMGRAKSESSEDKDSDSCSTDSRYSTVSSSVNKELPSVPSSMMSDSPRPTPKKAMSWDFSSFKSFPKPKRSSTMSTVETISSISGPSSSSSSSSFSTSSSAKSKPNTSLAATPITTPDTTPASTPGQTTTTVAHAPVWLVNASQALSFLTTEHPKAMTAISAVLITIGSIPAMPAIAAGAGGAFLASGTAHAIGSIAVGVGSLLKTISDASSSGPNQPSQQPVQETAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUF6</accession>
    <name>A0A2R6NUF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v8210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUF6"/>
    <dbReference type="STRING" id="98765.A0A2R6NUF6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR76829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37259" checksum="50AA26CB458F31F3" modified="2018-06-20" version="1">MNTLVIFDVAALLSALVLLFNLCKQEYRRRVGKEYSIRLPPGPSAIPIIGNVHQLPTDYQEKTFFEWGRQYGGIVYAKLFRNPAIVINSVEIARDLMEKRSAKYSDRPVFTLLEELLGWKCMPTQMQYGERYRKHRKWMQDTFLSKPVLLSYQPIQRREIYILLSRLSESPELFETHIRRFVAALLMEIIYGHRVQSDTEDEYVELAERAATETVLAGSAGSSILSLLVDFFPVLKHYLLWLPGSGFKVKTNHIKGLVTRFLNEPYNMVKEQMALGTASPSFVATLLEKHRNESGMTEDDEDDIRGSAASFYIAGTDTVRGETFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV74</accession>
    <name>A0A2R6NV74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV74"/>
    <dbReference type="OrthoDB" id="2804335at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="33136" checksum="A1B932421218B26E" modified="2018-06-20" version="1">MAAPGADIPEDLFERILDFLEIVPEGTKDKKSNLVKCALTCRYWARRCQPRIFEHIFLRSREDVDQLLYFLESSLGRISSYVKHLYLSQTAAAFIPWIHLVPLRLFPKLALSPTITLVFHTPWEESDANQYARFRSIHYMLPRAYPMFSSHISSLLLFLQQFRCFEDLAHLVGELHSLETFDCSMVQWFRDAPETYVVPACPPRLDKVTMMGCTQDAAGVLFLIGRRKGIQQNGTAVLPFRLDHRQHALACAIVCNLLGSENNVEFRTEKVDRAYSERTSIFLRSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVJ6</accession>
    <name>A0A2R6NVJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v7806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVJ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NVJ6"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="9">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="9">
        <location>
            <begin position="172"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR77616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="805" mass="92105" checksum="E2F8032B65544277" modified="2018-06-20" version="1">MVDIGEDTNTKRSINAISGPSISTNTLANNKWFGHICYMYEKDAKKFMHLQWYQHGSKILLQETAHPQALFLTDECDDVLIESIYQKANLRVLGSTEEEPPVAPDTEENSFYTGLRWDKQNHAFFERTEEKRQQVLQFCKCGKPCESCGQKRLLKERQHWTVKDDVLRQGDVHYHIHDFVYIRPAIPKTDVYIIGQIIRIHRGAREKAHTVDIRVFERYDLVARLEKKSQFAEHETDQRRLFRTGKVYENENVSAIEGKLYVVHSASLSERKLEKWVSHDDHFYVDLQSKSSRPKQVDFLEDLPLKTFKRCEECYGARRELLEIQKTLEAQHEPLRGLELFSGAGGLSAGLDQSGFVKTKWAVEWTTSAAMSYAANHPETVVYNQCVNACLKHAVDTEEGKSPEPLPSLNKRVREKLPPMPKPGEVDFIYGGPPCQGYSKMNHHKFFLLENVDGLFDFNSNAEQNGNRTVGGYKMGAVKFILSAMISLGYQIHFRLLNAGQYGAPQSRLRVIFLGAKRYLPLPMFPIPTHCTADDVYKRKLPTGDTLYPLVRFRPYDADLTNALVHLQYAPLLPVTVEDAISDLPKFDWIDPHVVFASTDNDLSEIGRRHLQGIKRFSVVPDPDADSIRPYCGYNKKTPYVHEPLNRYQRWIRSGSDQVAYHYTARFRSNIVERTVWVPLVPDANYTTLFRRIDGKGQFKTALTTVNPNCKTGHVLHPTQKRVITVREAARAQGFPDSWEFVSEQTIPAKIIQDQFRQIGNAVPVPLALALGKSVGSALVSMWQEDDLREQVGREHSPEVPMNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW32</accession>
    <name>A0A2R6NW32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000762">
        <property type="protein sequence ID" value="PSR78039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW32"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="201" mass="23436" checksum="FBD9AE6BE1476D3E" modified="2018-06-20" version="1" fragment="single">LFYEGQFCRALNIVYISKQCKQELKRIVQIGPLDELPAGMNLPAFRSRRAPMPPVMLYGWMINQDDWFEYAKEHGYSVTTEIITFEGEDDPDFELQDFDEDNLPAEVITTTEDKYSSVCNAFWAIMHDLGIEPIDLDPVKLTLGCEKHERLVVLTDNYHDQSSLTEENLRELQKKMGRNDAPTWHPWTYFQWNRDIAGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW64</accession>
    <name>A0A2R6NW64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000758">
        <property type="protein sequence ID" value="PSR78108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW64"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6176" checksum="9E59BF516CBEBE97" modified="2018-06-20" version="1">MAHFSNSGVAYPSHGYQSQSSPVNGQKSRRQPAPFQDVEESAIASVFFISAQHRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWX3</accession>
    <name>A0A2R6NWX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWX3"/>
    <dbReference type="STRING" id="98765.A0A2R6NWX3"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="15997" checksum="BDA600EAB56883FD" modified="2018-06-20" version="1">MTTITYDTLVRAGISCTSAYVAADEDQSSTFTNPPFAKGSRGINILPDTFFSPQEATPDKYDLLVIPGGAKGAETISSSSPVQHLVRRYLQEGKYVGMVCAGSLAALTSSLPKQPLTSHPSVKAKLADHFEYSDDPVVISGKLVTSRGPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXF5</accession>
    <name>A0A2R6NXF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v7122</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000706">
        <property type="protein sequence ID" value="PSR79206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXF5"/>
    <dbReference type="STRING" id="98765.A0A2R6NXF5"/>
    <dbReference type="OrthoDB" id="2802867at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR79206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25376" checksum="47A674A8BB4BB187" modified="2018-06-20" version="1">MDMIKFLGLDVLFLQLPLQPTIILCSAKAAFDLMNRRSNIYLDKPQVLMDELTGWGNWALGMLPYGVKWRNTCQCFHQYFNQGIIHQYHPVEVREVRAFLRRVIDDIGEINAQSISQTFVGIILDIVYGMPVNSMNDNYIHLVRHSIEGFSQSRVPGAFWAESIPILKYIPSWVPGASATNFGAQYKPFVNEMRDWPFHTVRDNSVSSTLHLPKLRVLTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY31</accession>
    <name>A0A2R6NY31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000687">
        <property type="protein sequence ID" value="PSR79715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY31"/>
    <dbReference type="STRING" id="98765.A0A2R6NY31"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="124" mass="14049" checksum="7830789E737E1511" modified="2018-06-20" version="1" fragment="single">EEERAEAAAETLREDLDNLKENLDKKNQAIQAFRQKEGLNLEKIGAEVDPKGHVVINDQFNTSVQGVKCIRDVTFGPSLRSRLRRVNIAAIEYIKNGHYHVNYHAIPSVVYTHPVVAWVGKTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYL8</accession>
    <name>A0A2R6NYL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYL8"/>
    <dbReference type="OrthoDB" id="3256870at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="15537" checksum="3B15E3E25D848DF8" modified="2018-06-20" version="1">MAAILDYNMFSDYHNHIAIAPVIDTMHKNATGGPLYYQQHEVIQLIEVAAPPPLQEQHPSTITSSSVASSSSYTSSSCDESSIDSEEESAGSSYCSSDPEEMEESSRSCCDDTFGTRLNRVLAWRDGFAKAMGVAISPGTSIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYY4</accession>
    <name>A0A2R6NYY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYY4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7601" checksum="221D0C454996FEFE" modified="2018-06-20" version="1">MHLSHIQAHPHRNLQGGIISLRSASCNLNDDGDNDEQHGYLLPLDDEYRPEQVGVVVWQTAIKRDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZX0</accession>
    <name>A0A2R6NZX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000612">
        <property type="protein sequence ID" value="PSR81641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZX0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8241" checksum="4766DB98E0F01438" modified="2018-06-20" version="1">MTQSIPPKVPRSLLKVLLRSDPSTKTGGCAMSCLWWGVERIGPNISAVPSELKFRSLKRPVFRRFYVEVCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P057</accession>
    <name>A0A2R6P057_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000604">
        <property type="protein sequence ID" value="PSR81917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P057"/>
    <dbReference type="STRING" id="98765.A0A2R6P057"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR81917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57309" checksum="E5AC78DBC00F9474" modified="2018-06-20" version="1">MYYSSPDGDILNGLDYSQFANGNSLDHLAGIATFMSNSPPSMGGNASVSTPSSEDPNGVSMSPHSASGLGSVSTSDDAGMSLLYLSWPANLPDITVTRHLINAFFTHHIHASRLFHPSSFFGSLDLHPTDPKFPCSAVLHAMCAVGSIYTALVPTNNISDSYAFDVMTGERRPGKQRITSFGELQAKFSKACIEDGLDRGENLFECTQAQIILTWFYLSQARWVETLVLPPGRQWSHDKDVLSVHLEDQMDSFIVFTKASILISRVKNFNLRFKSLAYTGDPSVISPNMKSLDASGGLENFNPKDTPGFRDLDQLVTSFKASFPPHMKNPMKDDKLDAYLYSAWNVVHLSQILLHEPFARPGSYACISAYKILSSSRAIVEFLHSISSTSYDVSSMDLYPFLCWFMAGRVLVRFLKAAQDAQAQDQVIPLQAEINFLRTMLAKAGERVPLAYRYAKMLGDTLVQTCGVQEVESPSAMPPREFNYVSQHYDYTASLFSYKTPPMPPPPSEPPVTPPLAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0Q0</accession>
    <name>A0A2R6P0Q0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000579">
        <property type="protein sequence ID" value="PSR82656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0Q0"/>
    <dbReference type="STRING" id="98765.A0A2R6P0Q0"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR82656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="376" mass="43774" checksum="84E3D6B46741CF3F" modified="2018-06-20" version="1">MAEVETTVHLQRDDVSSTVHPAHELDSEERFWRDLQPWLKKRGYLLRPRYHPGWVASWVGTKKKWYDCEDGHTGNTLVLDAIKVSDGTAVGLKQLELGQEHGSNEIDIALFFSSEALAKDTRNHCVPVYEVLQIPDNENMRILVMPLLRRYCDPQMQTVGEAVEFFHQMFEGLYFMHEHHVAHRDCHRLNIMMDPKPLYPIMYHPAEDDMKHDFSGRVKHLTRTARPVKYYWIDFGLSRKYDPKGPPPLETDFISGDKTIPEFQGQNKAYDPFPADVYCAANIIRKDFLQTYRGVEFMRSLISDMTQDDPRRRPSMDVVVARFQEIRAALSLSMLRKRLVPHDEEGVISFFKGIRHMYRTVGYALRRIPPVPTPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P164</accession>
    <name>A0A2R6P164_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5902</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P164"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR83098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="74686" checksum="683F6DF8792A6332" modified="2018-06-20" version="1">MSQPVSREPSRPGSLSRKPSRFSSRAPSRARGSRNSSRASLAYLPQGPEDLLLTEGAIGEEAAELLQEFVHPHQHDAEHIDVEEDQSDTASDAASTGLRKELPWYKRPSPLWFLLLIPFAGAATAATMAPRIDIYTQLACAIHKPEYTIGRGSDGSGLPTLSQLLVTFSSEDERRLCAKDPVVQAAVAKLSMAMTLTLGILSCLTGGWWGSLSDRFGRKRVLSFSVFGVLVTDVVFLIVYRYYTILPGGYWFLLLGPLLDGLLGGMTTVSAAIHAYIADCTDAASRTRMFSLFVGLLFIGIGLGPTLGGIIVHLTGSVISVFYFVAVIHIFYSSIIWFFIPESLSTRRQMEARRKYKEQLEEVKRAPKGRGPFAYFRRPFRFLSPLALFYPAPVMTNGSPLKRPRRDWSLLLVATAYGTTLSVMGSYSYKFQYISSKYGWSSEQLGYWLSVVGGTRAVFLTIMLPLIIKFIKSKPRAPIQLPVSPSEPLEPGDSPSLREAEPLSADRRGSHSLSFDLGLARASLVVEVISYTLLPFAPTAMLFTVCSMMGAFGAGFSPAMQSVALGLYTQSGGTESGKLFGAMSVVQALSSQILGPALYGMTFMATVETLPTAIFFLSSGAVTIALVCLVFVRLTKGEQDDMEALVFIPEGSSNRATQDSIINTDVPIIIIEEVSSKPSSPAPTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P183</accession>
    <name>A0A2R6P183_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P183"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9482" checksum="763BF447FAA89192" modified="2018-06-20" version="1">MYKTILLGPGAFIAIRTLGTTKLLGIRNNSSGMTTEELATISRLDIGDKQPVDMVFSESVNMQQPSLIVVNDQGDVYKCTPEGEKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1H0</accession>
    <name>A0A2R6P1H0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000563">
        <property type="protein sequence ID" value="PSR83281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1H0"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="7910" checksum="65F9615036FA6DA6" modified="2018-06-20" version="1">MGDIKTSLEMTSEPVLVGLGAGALFRRTNIRDLYKRADHKVLPWKMEDICHPHITTEAIVEAETPFAACDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P201</accession>
    <name>A0A2R6P201_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v5624</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MLYV02000551">
        <property type="protein sequence ID" value="PSR83810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P201"/>
    <dbReference type="STRING" id="98765.A0A2R6P201"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="40"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="244"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSR83810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="326" mass="33688" checksum="53A2BBCB916F5F9D" modified="2018-06-20" version="1">MANGMRGISPTTTEASCTPSFGHREGAHLCTGPSPIRLISDIGPVKGSSNPDLTCGLSAQKAELVVPANPGSVFTVQWVGGDGTSNWPHNTGPLMTYMASCGSTTCDQFDASGAKWFKIDQLGLKSDGSTWNQADISTNRSTFDVTLPQNLSPGGYLIRHEIIALHLAVTVGGAEFYPMCTQVMIGGNGNGTPQSTVSFPGAYSDTDPGIYDPDIYNPGSNYTFPGGPVSNLAGSDASMAVSATMTPPFPSGTNVGTPAPVSPTASMDTPPSSETSADAIPSPSPTGTGASSDEPGSTCSLKARSGSPQKRHFKRFLRRAMPHASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5J2</accession>
    <name>A0A2R6P5J2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5J2"/>
    <dbReference type="OrthoDB" id="2688840at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR85845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="400" mass="43784" checksum="FD4C4D0D4E42CB52" modified="2018-06-20" version="1">MSSPRHSPHRRRSHSTSSPQSSHQFAVEKLRPSSKRARPSTPRIPSYKEFAPEQKLDVDRWRNGKRARRDRSVSTISFSGQPDILSPVSKISGSTPRGPCLFGASSVFREESALALPLSPCLPSTSDAFHLFSGRSRQTSTCHSSRMPDNVSVIPIEETSTDAEDLNKLRSDAFCELQRSIVDSGEGLVSRMRDWEESRSRPSYRLPRPSRNHLEAERGRQQSFFVHQPTSSHPGLEQNDSDEDDIQIVSEGSPSVSSLPWGPPRPKKALSLGDMDIDEPESERGESERCTSPFDSTSGSSYYAYEDDAPSLSSTYTSSTNSSLTSLPLHSHSPSSPQAQSYLSFGVPSAPSPSEKAIAALTLVIANGAGGLNDYEAVRAVDSQSPSVSRDESLVGEMWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P907</accession>
    <name>A0A2R6P907_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v5154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000513">
        <property type="protein sequence ID" value="PSR87441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P907"/>
    <dbReference type="STRING" id="98765.A0A2R6P907"/>
    <dbReference type="OrthoDB" id="3246760at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="272"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR87441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="504" mass="58212" checksum="7F7B9210C8AEDCA9" modified="2018-06-20" version="1">MPRISQRELLLYMLYSYDLRIQEARMQSEMLSLLDLDITHLFDDPDDELPTSPTTSDSSTASTASSKMTEDSSDEIDFDEELLRIDKDILSLFLGWSNFRDDLADFLNTTRVLNDMPPAPRNSQFNILDDHYENREHEFRRRVRISPATFDALLPLIENHPIFHVNDNHPQLDVKRQFQMFLFCAGHYGNAASPHYIAEWAGVSVGTVNNCMKRVMVALLHLHDRAVRPPTAEEKEKSKVYTESRTCKHWRGGCMSADGTKCCFFCRPGFFGDAWFDKDKNYSMSLQLVSLLHNCRIVDYVVGHTGSAHDSTAFQCTQIAQENERSKYLSDGEWIWVDSAYPLTPWCVAPYKKPAGGQVTKDQSAYNYYAAKVRVRSEHCNAMLKGRFQSLKELRFPLESEEHLKFLIMWIRCCIILHNLIIEVEEESTTVDRLWYTKLREEGYEGRGGAERMDADEEDPDLPFVDEEVAGVRTEGQSFRHTLMQQLLASSRYRRDQARHAANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P9E4</accession>
    <name>A0A2R6P9E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P9E4"/>
    <dbReference type="STRING" id="98765.A0A2R6P9E4"/>
    <dbReference type="OrthoDB" id="2787357at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11682" checksum="F00FD09C62BB314D" modified="2018-06-20" version="1">MPAGNPLLKGKGKSGPNSLGKNGYDNGNWPDEDLLEAKLRDYATEQLTQKQRLLRLHHKFRLTIGMRTLAKLNKHFNIPSVRRPVPTEIADQLVLNKMSDLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC42</accession>
    <name>A0A2R6PC42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC42"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="420" mass="46687" checksum="1312447F748F768B" modified="2018-06-20" version="1">MIPNSVDTTANILALRVSTLLPPLLSMQRSSWEQGSAAQALLECHRFQPSVLPNVLNYIYGLVHDSIVRQGPDGRLAVLLNGDGSSDSGAVDPACIGESLYYLLHMSAKYPGLLSEQDCVLLDDRVTWMLTFIIDKCPRAQVPESSTSSKDALFSHRTDALQIWSDTVYMLSPFLASSSVFYAHPNRSSTRFGPQDLLEMSLRQILLASTILQSSSGEWSHTFDLDKGVFQRKAYWGVGNGWVCGGIARVLKTLAEAIEADDSIADVLLNHANLNLIQDCYNTLRKTLDANLHHIRSDGLFHDVLDDKESFVETNLSQQLSYTLFRLLDLHSYSSSRVLERLRLPLLKPTTVIEWEGKASLMREAAMCKTDDWGFVRDVCGSPRFDKAGTAAEGQAWAILMEVARAEYMTHKEVHTTSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG10</accession>
    <name>A0A2R6PG10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000495">
        <property type="protein sequence ID" value="PSR90490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG10"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8213" checksum="321A44D4EFBB4666" modified="2018-06-20" version="1">MNHRHTRDGAHVPLALRRSGCDRLGILPPDAVRAIRNASCERVVWHKPDASASPETHDKDEAGNEEEGKDEYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG86</accession>
    <name>A0A2R6PG86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG86"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7120" checksum="C5A5579F4E30F052" modified="2018-06-20" version="1">MDSVVQRRDDKMLFGLVAVPALDVMEGRGEELVDNWSCIRTPYNPTRQQDKIDPMSPEGAGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJE3</accession>
    <name>A0A2R6PJE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000483">
        <property type="protein sequence ID" value="PSR92027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJE3"/>
    <dbReference type="STRING" id="98765.A0A2R6PJE3"/>
    <dbReference type="OrthoDB" id="3020801at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR92027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="484" mass="53242" checksum="844F1748CB338018" modified="2018-06-20" version="1">MPKTPATYQLDIDFRDCLQEAYAQDALNYVKSLDCSAEHLQPLSPTSMPAGSSATGSVPGSVPGSVPGFVTPSSTCSNALPPNDPLLPPPSVNSQEQQRRRKHANLNRLKKRALARAGRSALDYKPREQHMHKTAEAGRFKVETDLGGSSRAAEGAWIGLNNYKQKRGQPRTLEGYKEAGFRILKWDGLETITLTDKQGMVFGVLCGRPADSPGKTWAESCEGVTTALRQAEADLDFDGSPIIPEISSEKKGKNAKNRRGKFKTASMGVSYGGGQSVPAELSHTEENQRVLDALKSNPDFIRMVKYGSSMFAYYAPRLYNNYANTFLRLQQNQPELQLPVVGSIFSAISLNLGGQVVAELHKDFKNLAYGLCHICALGSFDPELSGQLILFELGLIIEFPPHSSILITSAVISHGNISLQVGEERFSVIQYTAGGIFRWVEYGCRTESQFAKEEPEEAARVWNERPERWKEAISLFSHISEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN32</accession>
    <name>A0A2R6PN32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN32"/>
    <dbReference type="STRING" id="98765.A0A2R6PN32"/>
    <dbReference type="OrthoDB" id="3253137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="365" mass="40330" checksum="9F17FDE3335EA54D" modified="2018-06-20" version="1">MEIIVNELADRRTRPTPVDRRLISERTAKRLRLQTAPLHIYRERMGRFSRRRYQLDVGHSEEEDDTLESSEQFIAPEGVRLNSDLYDAYAPPNPDMGLALSSTDLSPLSTPASSIDRNASPMPASPPSLFPSRIWRNSISGSSWTSQNNSRHSSHSRATDFNNFTSNRRSAARESELASNIVRPEESHDGTWRFSSVPDRPSEGRSSTSLSPLRSNRQTFPLTAWSDPHLRINAEGDAAPQIPEENSTQSSSQLWYSLTAAAPLVTTPQTGPPPPPPEVSGQRRRVTPRLRRGGVRAPESMLPRQASPLSANWSAAFLGQEGASHDETAGLEGGSQSVAGMNEITRQHPEQSLQLLTPRSPDSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNK1</accession>
    <name>A0A2R6PNK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v4425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000447">
        <property type="protein sequence ID" value="PSR94557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNK1"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR94557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32506" checksum="C2035F8D201E81EF" modified="2018-06-20" version="1">MTANMSAAKSCSSTHSLVWLSTAYELAYIAIDSDPYSKLSQLIVTWLPEDSTDVHLDYFPPPFTTSACIRLVLLASLTQLSARLALKNFASFPLIPCTAASSRVLYVPPSQIPTPLTHDPSKPSPAPVPKKDKGRILFTLRPSHELVNRGPYHYARHPMYTSVSLAFLGSGLLHLSSGSFTRSLVKSSRLSLPVFSRNWAELLPQTFAGILPVSVVDALSNSWMYARWDVGRWTGVLAIALSFVALGTFFGLVRMANSAGGAIQQAVDFASMGPRIPFYSRPFLAFRGCPSMMPQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVM5</accession>
    <name>A0A2R6PVM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000436">
        <property type="protein sequence ID" value="PSR97471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVM5"/>
    <dbReference type="OrthoDB" id="2734540at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="487" mass="56218" checksum="8B345F42EC2BA6B5" modified="2018-06-20" version="1">MLLDFDILIVTMCHLERKEDVSRFMRTCQTLHAAGIPILLSGGVYLDEKRQITSFYNFMSTGNGRRYQHLTTLTISLYEWQEHQTKRMIWRLLYRSRALEKLEISNPEFTDEYLRCGDAISMLPNLKELTMSWDDPSELQGMFAKMVSKLTKVRLVFYPADIWIDPIQGGIEPRWREPVPEDLGIRWINPVELLEKFTSSLEQLDVVSAGFTVTDIPYINMKHLRIEWLGYPTLPSLVLACPNLRTLITRCPHSDFPDVDVNEVRQYNQSFQQQTSWATLDYVSASVNELHLLAICCKIRYLDLNCLETEEEAQMLSTVLPDCHPSILHIPFGEFNMELFPTIAQSIHSDLLHLILSVNLEPYSSVQAVRVLDLLLESLHPLSISKLQLNLRWTASGFKRLWRFPDENTKPVSTELFLTDLDPEALACRIASSVPSLKYLSLEVNHGDRAKTYWQVEEEGSCRTSKGLDCELGEKVIFKSEIEHPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYY2</accession>
    <name>A0A2R6PYY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYY2"/>
    <dbReference type="STRING" id="98765.A0A2R6PYY2"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR99041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="273" mass="29664" checksum="98C5716DC6151205" modified="2018-06-20" version="1">MDPFNQQQNQNSRSLSSTTDPSQYTQYQHPSSSQMAASYPPSSHLSQTGGVYQPIPANATHAYQQQQQQQQMSAHAYSMSQSGPYPGATVYPGSAHHHATGSRSASTPSGQAYSAHGTMSPPHPSLQQQANTQYVGQHQQAMYPAPGYGYVQHPQSGAVMPPNSRPPPSPASSQVFQTDHLGRRVSASSGHRSASPPSPGIERFLCHKCDKSFSRAHDRKRHYETQHSSHPPLHKCPFCKKEFSRADSLKRHLDNGCEKDPSFTGGSSLTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBD9</accession>
    <name>A0A2R6QBD9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v3831</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBD9"/>
    <dbReference type="STRING" id="98765.A0A2R6QBD9"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS05451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="444" mass="50688" checksum="6ED7FA166DF6525A" modified="2018-06-20" version="1">MAQAYDAGPSVPSGPGFRQSTSESDSGQGPNDPKWEGYLITAVKDPVKELAETKDTYVSYLVTAKTNLPIFSTPNPSSRRRFTDFVFLREHLAKDFPACVVPPLPDKHRLEYVTGDRFSPEFMERRRLDLHRFLQRLSCHPTLQRSTLLRAFFESTEWHVHMHQHVAHPPGPEHPNGVFDSISDTLLNAFSRVRKPDERFLSMREGVDKFEDGVVVSERLWNRVRNRTNDLTGDYHDLAVAVQGLGFLESGITDPLNHFSNTLLEFSALLRHLTQTTTDPYLIHLHSMLQYSHANRAVLKLRDQKQMDFEELSDYLSGLTSERDRLAAVISGRAGSTGLGLGSYLKDRVDSLRGADDDRSRVEKMRKLDTKIKELEDAVTAAHDTSDAFSEETLREQKIFQYAKEAEMKEMLGHLADGQIEFYKAAMEEWERIIPIIQRIRVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBI8</accession>
    <name>A0A2R6QBI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v3771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBI8"/>
    <dbReference type="STRING" id="98765.A0A2R6QBI8"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015344695" description="Cupin type-1 domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="8">
        <location>
            <begin position="54"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS05489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="399" mass="41621" checksum="05B49A611AAF4733" modified="2018-06-20" version="1">MRSAISFIAFVMAFSTRVLAQTEAEQVASLRAAASNVDRIKLLQDNEFVFDFLHAAVGETTGAGGHTVAASSTTFPALIGNGMAMTIGFLGPCGYNTPHTHPRATEFNFAVNGTLQTGFLAENGARFVFNEVPPGSAAIFPKGAIHFEMNNGCEDMLFVAAFSDEDPGVDQIAQRFFGLPPSFIAASLGNIGVEEVAGLEAMIPDNIALGTDECLQRCGLNRGDQPTAQRQPRVSANALPSGFAAPSAAPAPMSTPVASASASAANGAPYSVPSSAGAYVRSTGYSTSQTSTSEHSVSGGISNGGVSITNSDGKPNALILSLIVVVGVLAAGYVALAVMYFYRRHQEKKSRMKGSKYFQTGSDFAPQGAIFEAEKAQPFEAYEGSSEARSTPYDPPSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEP4</accession>
    <name>A0A2R6QEP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEP4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="9710" checksum="A6415470301F4168" modified="2018-06-20" version="1">MLNLRKVGEPENEHYDDAGSRSLGVGFRLPSFASIAGNMGEDLDHGPEEEVFDVVEDNVCIVQAEAAAIPVAVVEYRASQDNTASENCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM51</accession>
    <name>A0A2R6QM51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM51"/>
    <dbReference type="STRING" id="98765.A0A2R6QM51"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015304210" description="Cupin type-1 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="4">
        <location>
            <begin position="128"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS11007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="402" mass="43848" checksum="7470072122670C2B" modified="2018-06-20" version="1">MARAIRLSLLLSVLSALVGVSTASPIDDAQVRDFLVERDTAIRPLHFARRDAAGIKNRHLRPEDHIFHTKRGSVSSPDVGQIANFNGADPEPIRGATGDTFISNSNHAIDMQNVDNVAAPTTDAGTVPNLKWSMSLSHTRLLKGGWVREQVITDLPPAKDVAGAELRLSPNAYRELHWHRVAEWGYVLGGTGRITAVDENGRNYISDIKGPTNMSDPDIYYFPPGVPHSIQALGDGLELLLIFTDGNFDGTGTTFMLSDWLAHTPLEVVAKSLGVNTSILGDIPQKDPYIYEATVPPPPLGQADEEAVSSPQGTIPSPYVFQLSKQEKAMAPGGGGWMKVQDSVTNFPVSTMLASALVFVEPNGMRELHWHTNDGFKSQLLIVEGTIRKGYRTVRDSKRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM59</accession>
    <name>A0A2R6QM59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v3305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6QM59"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812:SF9">
        <property type="entry name" value="MYB-LIKE PROTEIN X ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36812">
        <property type="entry name" value="NEUROFILAMENT TRIPLET M PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="729"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="824"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1140"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="738"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="855"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1232"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1306"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS11009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1347" mass="147625" checksum="D094DD3A398B0B96" modified="2018-06-20" version="1">MTTPKARRAPIRPLPSRVAQAPPPVTAPAPLGTPPVVSLAVNGKKKKKRKGKGKSTVNNPYGDEDEYEDDEDDDLPTLEPMNGAGVNGRHTSISRTGLSPELESVHLSTTASLSASVAAAARLNPAAVAEAELLATADHLARSMDVDPEGGGGGGGNEEYWASFPEHLRNFVRNTYSQLRSSGDEDQKTQAMYAIAQQIHAGAGVNLTANATVRGITRSATARYPPGAFQTSMPFDPSIFTDPAFTLAMEQAAAANGLHPPLHREATAPANVVVLNEYSSDGHEYPEDEYYSEDDLDEAHATEAQFTLSYEENMAHLDATRLHLDEGYDVVDATGRRRKNKKKKRNSVVQPLTPAAPPMPAPIPVSAPNIPAVPSTNLPPPASVPHNRMPAPRPPPAANPPPSSRAAGKQPMSYTAPAPAANPPPPSRRAASKAPITSHAYQHNHAHHHPSPPASNTAAPHKPRPPANGTSQASPAKNSKIWSTSTSEERERIKEFWLGLGEEERRNLVKIEKEAVLKKMKEQQRHSCMCAVCGRKRNAIEEELEVLYDAYYEELEQYANYQQRYISSGGTLPPPQGPGPFPGSVELDKNGAVIGPHTISNAPPRAKAVVNGKRVVKQAESEFDEDDAEEEEYEEEEEYEDEEEEEEEEEEEEEADAEGEDEEDVKPPPERRTAPRRRAAANGKAVARDGLVNFGNNLTVTGAGNILTVADDLLKNDGQKFLEMMEQLAERRMQREEEAAEDVGEDSEEEEEEEGDEEEEEEEEEEEEEEEDEDEDEEAMTEEQKMEEGKRMFSIFAARMFEQRVLQAYREKVAQERQLQLLRELEDEDKLSKEKEAKKQTQNQKKKDKKRQQKLAKEEERAAKAAEKAAEDAAVKAKQAAQEEEIRKRKEEERARKEAQRKAQEEERLRKEEERRKRLAEEKEREAERERKRKEKEDKVRAERKEREERERRSREEREAKLAAERAARREQQDKEEREKKLAKEREEKEKAEKERAEKEKAEKERVEKEKAEKEARERQQQQQRATAKAARPPTSPRNATASGSTPRSPVPPAPQKKAINKPPVVVPPVIQPVRTASQQRPSVITSPALPYPSAPMTPQMSHMPQPGTPVFSSGGGIIPPVMSPRVPYTPNGPFAPGFVAGPSIPPPPTPLAPSAIPRGFGTGPPFDTPFTRLVPPAPIAPPGKASQNPLTSPTQLAPGARRSSTADPGPITRPVASTASIAPIARPAGEPSGSGSTSPSRRSPSPKGVPLGSSALVADEDEIVPGAPGRRSAVPGPGGWGPATASPRSGGPDMRMPWGASGPGFPSPRPPLWNTPAPAPEWHASPPFFNAAFTNHNPSPPPHTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUI3</accession>
    <name>A0A2R6QUI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000310">
        <property type="protein sequence ID" value="PSS15410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUI3"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS15410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7059" checksum="E35B81A10357C64D" modified="2018-06-20" version="1">MSPMLQPFISISLGTRLALIISDTVILALTWRKTFTHRMEAARIGVETPLSDLLLRDGSPFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0Z8</accession>
    <name>A0A2R6R0Z8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000286">
        <property type="protein sequence ID" value="PSS18898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0Z8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7462" checksum="DE936BD2DDC6AC89" modified="2018-06-20" version="1">MRRRRCKISPHEGSKAISFFSWGRELWMKVDINTEDHGWILWVEYLPWYAGLEHGKVRGLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7F6</accession>
    <name>A0A2R6R7F6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000267">
        <property type="protein sequence ID" value="PSS22698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7F6"/>
    <dbReference type="STRING" id="98765.A0A2R6R7F6"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS22698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="424" mass="46273" checksum="EA77D6685982D0ED" modified="2018-06-20" version="1">MSFFTFISPVSSSMVAPASFQIADELNITSEIEVSMTISVFVLAYAVGPLVLGPLSEIYGRSRVLQIANLFFLVWNLACGFAQTKSQLIAFRFLAGLGGSAPLSVGGGVLGDMWNPERRGRAVAIYSLAPLLGPAVGPIAGAWIAQTSTWRWVFRSTTIADAVVQLFGLFFLRETYAPVLLERKAQKIRKDMDAEKGGPRVVRTVFQTADRSWKELIVRSLLRPFILFAQEPIIQLFGVYLAFVYGTVYLVLTNIPGIYTNLYHEKIGVVGLHYIALGLGLTLAAQVNSRLLDYTYVRLKKRNGGVGKPEYRLLPIIPGTFCLPIGLLVMGWGAQERVFWIVPDIGLALIGFGVSSTFQGLQAYVIDSFPRYAASALASVSCFRSLAGFGFPLFAPYMYNALGYGKGDTILAAFCLCVGCPAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIK7</accession>
    <name>A0A2R6RIK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000248">
        <property type="protein sequence ID" value="PSS29866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIK7"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS29866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="197" mass="22049" checksum="494E3F60C1895747" modified="2018-06-20" version="1">MTFFTDCYPKPFLSGSLTATSTLFSADEIIFPIPCDRVFTIGRDPALAANPDDSGYIDNRYNFVNGVPVLPGQSFAIPDKGTLRLGTEPNHLVFTFKEFRPNSVCNTHYNISPGYRLPYEQIQHFYEFGELLGQGAFGKVLKVKHRGTGELYALKVIQPEPRREIDETDPIRRDESAFKYRDLRLVTKTSGLGGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM65</accession>
    <name>A0A2R6RM65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000218">
        <property type="protein sequence ID" value="PSS31123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM65"/>
    <dbReference type="STRING" id="98765.A0A2R6RM65"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS31123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="798" mass="87589" checksum="051B0D6DA2317F61" modified="2018-06-20" version="1">MDEEDLAELRENRNLIDENEEMDLGGTEAELRRRAAAGTDTEDDSIANALAASLAPPPQDSVGARILRKMGWRIGQGIGPRITYEQRRTQDSASESLRPSQTDEVNDEEAQKHMYPRRDTPLLIVPRKDNSHGLGYVPGMSLNNSLGASGSGETKGPRLAAGFGLGALNDADEDDLDIYDGTLRSKGVRRVAYDAADDDDHKRMGSSLQPRYTGSNSRAPSTPSTSQIFRDGRPVLKGFALSNRPVVEDRWFPLPDIPKGWKPNPKRVWELDKNKENQTSLKGKERAEPPKTHAEWKKSLLSADERGSMLGETPLPATPRSVFDYMSQKDRERLDNIRNTLPGPRPSSASAAETMPPPPPPRIAGEIHIPQLHPSVAKAALSGFQPFTADPAKQARYTAFLHFISSDSTSLTDLGIKPNPGQSTEDFNKELEDYARSATVFKPLSAAMASRFKSAVVIENGPKIFEGLHTPSASSTLDEAEEKHEEKQDEDPRMTAIKLGMYGRLTREVTSWQPARLLCKRFGVKDPEADTAAADLASASQSTQDTAESDPNSAPGAPPLAITDGSVEGSLAQRKPGQRNLANIGLGEDEEQGKDTLTYQRPAMDVFKAIFASDDEESDDDDEPMPEVTKAEPTIGSIPAAVPTFGVPDSKPVHPVDEPSHPPTIADEKVDTASFKPTFVPRSDRESLKNKDKEKKEKKKKSAKTLVSFDTEEDGLQLTITAPKRERHKEKDGERKKKKRREKKENEEDDSMWVEKPAPEVVQALELDSIPSAPPPEMSQEAAAAGPPRGRKRAIDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPG3</accession>
    <name>A0A2R6RPG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v2309</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000214">
        <property type="protein sequence ID" value="PSS31928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RPG3"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1001"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1243"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1284"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1323"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1455"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1500"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1577"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1611"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1642"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1695"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1796"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="523"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="805"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="1242"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="1576"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="142"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="437"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSS31928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2031" mass="228194" checksum="F15D3CBA649D5002" modified="2018-06-20" version="1">MDKHQHSLSGGSSSSAIDLTGTPAGLGSSVPSSPALAPSDSRASFARRRTSWGRMEATEDPLRIDLADVEPRTSTPQRTGPAGWSKHEDPFFSPSEDESPSFDQPFTYSKPGGGIYGTSQPGPSSASLISSVYRAHDLDGHREDDEAGLTSNMSRPGTSSGWGQDTDVDPERSAASTAKSRRTVRYSASPSPLRKTGNTLATLSRSIRRVSLRVVNMAGMGIDEHVRLADVDDEKREDQEDEDELGKEEYDEALPDLSRSLPIRGRTLGCMGPTSKLRLAMFRFLVYRWTEPLILLSIIFNAVVLTVQAARNVALPADGPGIPPSIKGYFHAWEDYALFILFIFFTLEMFARIAVSGFLLDPEVPVSILFTAPFSSHQDIVLPPSASGDAPVSLLRHPSLAHSSSQPQLSMLTRAPSVVERLRRVRSNLMRPFALVHHSMPTSGPSEESTTGPSRTTSRPRSDTTRSVTPMMEKAQYLHSHMRNPSQPTFFSKALRSDNVDMLSLPFRLSVQTSHSTTERNLPYLRHSWTRIDFVAVVSFWISFALAMTGAERGTYHIGLFRAMSVLRTARLLAITSGTTTIMRSLKTARPLLTSVAYFVLFAMILFSIIGIQSFGGSFRRSCYLLPTLGEAEIPLGGQTCGAYIDPNTLDVVGFVMQDNSNGTVKGYVCPLGQICREEDSNPYSSIESFDTIYYAALQVFIVSSANGWSGLMYQMMDSEFFVSCCFFIVCIIVLNFWLINLFVAVITNTFSAIRKDTNKSAFGAAPLAPVIQDGDDGWTVVDGRRIAKTNRVKEIYENIRWCWVALALASLVLQATRNVDVGPTHQLILNQGELVLTIVFDIEIFIRILAYLPDWRGFLARGQNWLDIVLALGSSIIQIPLIHNSSIYPWLTIFQLARFYRVILEIPRMKPLLLAVFGNMYGLANMSLFLLLINYLTALVGVQLLRGDVQSGANGDGKFIIWGEIFNSFLGIYQVFSSENWTDVLYDAAQAEIPLRQSPIVILFIAGWMFFANYIVLQMFIAVINENFDVAEEHKRSRQASHFWAAQRPEKARAPWIRRMNPYRWFQARPKAIAVDQLPSNLVLPMQKSLVQDYTMPRNEALSRVQNKGRSGARHIPTKSLNLLRDLFSGEKPGGDVPLTTIRGNRRESVVSQDPIDEETERHLEVLAALNNETATVEDINDVLHERRAQKADFIRDHPTYDKTFWIFSQKNPIRRICQKLVTPANGDRIFGTPPSHIAHPVFQLILLLTVISGVIVEWVATPPYRRNYYLENGPIRGSWFDIAEAAFGLTLFIEFLIKIVADGFIFTPNAYIRSIWNILDFLIMLGIVVNLTTGLIFIGGLSRLTRSLKALRALRLITLIDKMRSTFESLIISGAARIWDAALLAILYMIPYAVWGTNIFSGLMNECNDSSVGGVGDCINEFGNTVAGDSFGFLVPRVWDNPAPSTTFSFDSFGASLLILFEIVSLEGWIDVMSVAVSITGKGQQPQQNASQANAIFFLVYNLLGGVVILTLFISIIIGNFTSKTGSALLTQPQREWIDLQKLIKRQRPSKRPKMRPLWQFRAWCYDRAVHKHGWWYRMMTALFILHVIALMSQTFSPQHTFDEIRNDFFLVITIVYLIDISVRLYGLGWGSYSANGWNLFDIIIAGGSLITILVVRFNAGGFSVQQLQKLFITSIAFKLVQRTNSLNKLFKTAVASLPVIISLLSLWLVLFLFFAILYVEVFSMTKWNSGENRNQNYSTMPKALVMLAFMTTGEGWNQYMHDFALEYPRCTNSSPSSPDSDCGSPAWSFTLFIAWNLLSMYIFANLFTGVVVESFYYVFQMTGGAKEITREEMRSFKKVWAEFANPKTGYLERPQFVKFFAKLSGIFEVRIYPAEYSIPQIQSRSKCDENSDPMLPSVRYGGVDLPKLQFNVNSIDRTVIKRRKNLYNRLYHEARISYEPGKGISFTNMLLLLAHHKLIVDKEALVLQDLVVRTETNKLVTDLADFDRVQSLLLMISHRRRYLATREQARMQSLMQQEMLLEAVEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPT3</accession>
    <name>A0A2R6RPT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000202">
        <property type="protein sequence ID" value="PSS32040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPT3"/>
    <dbReference type="STRING" id="98765.A0A2R6RPT3"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS32040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="7935" checksum="5697B4ACBA7AD7B6" modified="2018-06-20" version="1">MNHSARILPHWLLTGCIGWIAGFGQAGSALIPFLTGAIASREGIKALQPLMVAMLSFMLCIWIIVPNTSRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ42</accession>
    <name>A0A2R6RQ42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000194">
        <property type="protein sequence ID" value="PSS32150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ42"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="10546" checksum="8DD461400FE3653C" modified="2018-06-20" version="1">MNFSYNNGRIPGSLLDKLEEECPENQHIDWFLTENPKDLEIVKCVAEILEMNPEVENDDTSKWQTLVPEHLHEFGDIFSRKIKENASSQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ56</accession>
    <name>A0A2R6RQ56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000192">
        <property type="protein sequence ID" value="PSS32163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ56"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS32163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="627" mass="68888" checksum="1B741793DF9E9B56" modified="2018-06-20" version="1">MATTHSEDKKGDDLALAKTTSPATIDEKADLHSESAAGDDIIPGSEGVTEHEYATLRRVSDRLPYSAWLVVLVEFAERWSYYGTTNSFNNYIRAPMPVGSTTGAVPAWNRANGVAGALGQGVQKSFAIRTFNSFWVYVTPWCGGILADTILGRYNTIMIFSGVCLIGHIILTASASPASLEHPQTALGLLVLSIVIMGLGAGSIKANVSPMIAEQYTGKLRKETLPSGEVVLRDPAVTVQTIYLWFYAAINFGSCGAISAAFIARDHGYWQSYLVPTCIFAAIPFILLAGKKTYVKTPPRGSILLETTRVCKLALRPAFSWNPVQFVRNIRTPGFWEPAKTSYYPQGEAPASITWDDEFVGEVDRTMKACQVFLFFPFYWLCYSQIDGNLGTVAAAMELNGTPNDLIQNLNPISIIIMIPIFDYIIYPALRRWGINFSPIKRIYAGFIVAGLAMLYAAVLQHFLFLKSPCHDNQPSACLDENNSPRPAKLNVWIVCGPYILVGLSEIFASITSLEYAFTKAPKRMKSVVMAFSQFQTALASALNFALTAVNVEPRFAWLFGSFGVTSVVVGTIFFFTYVSAIIFAGSALMRNHSRFRDLDRREAQLNAIGQGDRDGFKDEGHVDVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZF7</accession>
    <name>A0A2R6RZF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZF7"/>
    <dbReference type="STRING" id="98765.A0A2R6RZF7"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="372" mass="40185" checksum="7A0831E4C4977A23" modified="2018-06-20" version="1">MDDDFALGSSVWGATEQLAISVPSPLLSQPSPAPSSSQDGFDDFDDFGTPAETIAASGDEADDDFGDFGDFGEGTQVDFVSESFEEEVSTPRPTGVAPLDWSPLHLNPIPSRPDLQRQLEHIAGPLWYSGAPSDFIGDPIRQAEGLNQTLVTPESRQLYDLLLPATQPTFKPVNWTRSRIRRQHLITLGIPVNLDEVLPRAGAKLPTLEIHTRPTSAPPAPYTAPARPMVSSSRGATPRSGTPQPGVRSTALATAQLRLGPKPAINDGKITSLLELDTGELVVNRIIRFEANIFLGNLLLLPAKTLDRHLNDLREQTAQTSALLTYLLQTRDALQQDSETYNKLIGELVGEAQKIKTGKRTGSVRRGSAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3H3</accession>
    <name>A0A2R6S3H3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000102">
        <property type="protein sequence ID" value="PSS36834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3H3"/>
    <dbReference type="STRING" id="98765.A0A2R6S3H3"/>
    <dbReference type="OrthoDB" id="3050185at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="16452" checksum="7E4334FB3B062FC9" modified="2018-06-20" version="1">MLLLLKPWCNIVRDLKRPEQSWAEAFAEFRNSASERIIRMLAGIQYYHGSAATAEGTEHLLPMDDSHYVMGGVDKLDGGGDAANTDTVVSEEAIACILAQQTSIAELSHAKYAIEVAKGAKIFAAGDTLRPRYYPNTQHNPSGLCCSHRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3M2</accession>
    <name>A0A2R6S3M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3M2"/>
    <dbReference type="STRING" id="98765.A0A2R6S3M2"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="330" mass="36763" checksum="8C7E868524939625" modified="2018-06-20" version="1">MKFAPSPELERLAQKLTHEGPECSVRTRIELYTCKDTNRDKKLRRELETAYNDEVSHSPPLPSFMQHNGEHTMTAFGLMQDHSTRKTLFNLIGTLNLAYPDHDFSHLRPSHFSKEDAASVLNSLSTTLVSPNRAGPGAPRSYSSYPPISHDFFPSSVPTSSSPIDYALPSPYAPSRSVSGTHPSLYRSLDGVIGLNDCEVFSYNPDMELDPHADDFSDDEDDVASVGDEDSSSEDEGTFEFDEDVSRAGSHQRSGLVRMKRRGGMLWSSHWFFVNKKMKRIMFITVWARSKGIDSWMDEDESFSESVAGERFFGWAGAVGAGARAMGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S414</accession>
    <name>A0A2R6S414_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000087">
        <property type="protein sequence ID" value="PSS37021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S414"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="11279" checksum="28A48A052048E57F" modified="2018-06-20" version="1">MELLARIRAAALPSGPIIDIEDTSPVTAIEDDVPLALETEIGSHADVLMRMAREIQDMHQNTAIAICSMHEDVSISKLNLGVLVQTCDRNLALARAHTTHLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S493</accession>
    <name>A0A2R6S493_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S493"/>
    <dbReference type="STRING" id="98765.A0A2R6S493"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="415" mass="46596" checksum="BFAE98CB300836E2" modified="2018-06-20" version="1">MAASPVVNGVQGQEKWNSMKDKDPEAPAALTNGVDVPNDTDIQADDHHVAQQPPDNTDYARTGSVVPDDVSVSGSNKLDGSNRGEKQIKPNKVYVGGLPEHTRKEDLESCFGKIGNIVNVELKFEFDNREAAEESVAKYHEGYFMGNKIRVELSHGGGRTAKYSNDPGACFKCGQVGHWARECPNASTSDTRRSSAPLIDRIQPPRDYLPPPPPRDYPAYDYPRYPPPRDARYGYDYPPPPGRDFRRPPSPSRDFRDYPPPLARPSRDVDDYRMRGLPPPPPRYESRPGYYPEPDLPPPGYPPRYPPPPPPPRDYYDRYDRRPPPPPGERYPPYPPPGVRPRTPITEPHARGREDIHRPPPRDYAGPPPDYRGRPASPPHARYADYPPRAGSSEAPSRYRAANQASMQVHVHTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4P2</accession>
    <name>A0A2R6S4P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4P2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13397" checksum="658E622DE34835C8" modified="2018-06-20" version="1">MTPNYPDFTSYEFSRNSGMAEILFHTFMDYPLTTPFPGVIVPQRVYRSQQTFEMRPPIRFMGRNTPGILLRNALALDFSGLAQANTIPFITGTSARIALRIIEAGNLFCAVSFLSRGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4T3</accession>
    <name>A0A2R6S4T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4T3"/>
    <dbReference type="OrthoDB" id="2756378at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="6720" checksum="F20E2754AD554C7A" modified="2018-06-20" version="1">MSESPQPVAFLNNTVGALLLGSIAAAVFYGVTSVQTYLYSRSNRDSNLFKGLVCLLLPVLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6N4</accession>
    <name>A0A2R6S6N4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000017">
        <property type="protein sequence ID" value="PSS37932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6N4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6329" checksum="59D01C39393FA034" modified="2018-06-20" version="1">MPESFGSKTSTKALPEITHVEQHEKHIEVQNERHSRAGGGYDEEEEEESRPLAAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6U8</accession>
    <name>A0A2R6S6U8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000011">
        <property type="protein sequence ID" value="PSS38008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6U8"/>
    <dbReference type="STRING" id="98765.A0A2R6S6U8"/>
    <dbReference type="OrthoDB" id="3242031at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="132" mass="15040" checksum="0AF4197563ED94D8" modified="2018-06-20" version="1">MPYIFEDLTGELTGSEFVDLNGRLYFRLHCTLRTPERAAYMIYDMTSTQRAGRGGVMVPVACLDFGANNALGTVSIRQGPYIEMERYLSRVARNNSLSRKFVASDGQTYTWTRKGDSQCEWEVTLKYSLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S714</accession>
    <name>A0A2R6S714_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v74</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S714"/>
    <dbReference type="STRING" id="98765.A0A2R6S714"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7565" checksum="3C34270715B60D23" modified="2018-06-20" version="1">MYAGALGDNAVERYAMFLTSLELSADITERRLALTRAKEHGLNMERVAIATAERTIEKAFSVSLGCCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S797</accession>
    <name>A0A2R6S797_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v29</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S797"/>
    <dbReference type="STRING" id="98765.A0A2R6S797"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-galactosidase" evidence="9">
        <location>
            <begin position="175"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS38122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="754" mass="81608" checksum="9FD0B2146DEE4559" modified="2018-06-20" version="1">MILLENALRSNGVTKIPITANDVYPSGDFAAGPGEVDLYGFDAYPNGFDCANPSQWSELPNYFVSAHESSAPWAPMYLPEYQGGALDSWAGDGYDLCEQLTGPEFANVFYKSNVAFGSTAMSFYMIFGGTNWGNIAYPGVYTSYDYGGAIRETRLLTPKYNEIKLQGLFYHSSPSLLSSSIIGNGAGLPFTDNDEIFTTTLVSNTNETSYYVLRQTSNNITSPTSFHLNINTTMGTIRVPQYGGEITLQGRESKILVSEYQFGGSTLRYSTAEVMTHLTLDDIDYIVLYVLPGQYFEAVVLGSAISASKVTGALSVSARIVKNTVVISGTPSTKSPSLVRFGNTAVIILDKFTATSFWNPRLSATYDLSPDSPSVLIGGPYLVRNATVSGSTLNLVGDTNATTTLTIVAPRLVKSVTWNGDIVNISASPLGLGVVGIVPGPDALLLPNLRTSLWKSMDSLPEVNPNFDDSTWVTADKTSTARQQKPYSGKFVLYADEYGFHTGSFVYRGYFNGNFATGVNISAQGGSYFGFSVFVNAHFLGSNQGYVGADTANSTFSFPAGSLTNQNNVLTVITDSNGLDTDWNSNDLFKNPRGIRGYSLLGGGEFYQWKLSGNFRGEDFPDKVRGPLNEGGLWAERSGAVLPGYDDSEWGSSTPFEGVSKAGVSVYRTSFELNVPPGVDTSLALQFTRSPASDSEYRSLIYVNGWQFGKFISNFGPQTIFPVPEGILNHHGQNQIAVTLWSLSKSRPLHRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDP8</accession>
    <name>A0A2R6NDP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v13687</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDP8"/>
    <dbReference type="STRING" id="98765.A0A2R6NDP8"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="3"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="19"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR70436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="495" mass="53369" checksum="527F5759755AC417" modified="2018-06-20" version="1">MLQLVTDRFATPDGSSPSCDTSNRKYCGGTWNGIVTKLDYIQNMGFDAVWISPIVANVEGETAYGEAFHGYWTQDINSLNSHFGTADDLKALASALHDRKMYLMVDVVINHMAAATNPPNYGGFSPFNTQSDFHNECFIQATDYDNNQTAVEQCWLGDQNLPLADINTEDDNIVNTYNTWISSLVQNYTVDGVRIDTVKHIRKDFWPGFAKAAGVYTIGEVLDNSTAYVGPYTQVLDAVLDYPNWFTLTSAFSTSSGNISALVATVESSQSAYKNSDFYVGSFLENHDQPRFQSLTQDQALIKNAMTWPFVQDGVPILYYGQEQGYTGGADPANREALWLSGYEEDKPLVTHVKTLNAARKAAASANSNFYSTAVKILSSTPNSMAVSKPPMLALLSNKGSSSSPEWTVASAGFSPNEQLVDVLTCSSVTADSNGGITVQGSGGMPQVLMPISALSKSGTVCPKVATGQASSASTLKTMLPTALALAILVAKIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDT2</accession>
    <name>A0A2R6NDT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDT2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5582" checksum="9BA8BD6CEB58B56D" modified="2018-06-20" version="1">MTEDERLDLEDAEEVCRRFLAWDLDAARGGAEGDVKRVLAEVVGRDASMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDV2</accession>
    <name>A0A2R6NDV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDV2"/>
    <dbReference type="STRING" id="98765.A0A2R6NDV2"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="444" mass="49994" checksum="EECF18E93BF4854A" modified="2018-06-20" version="1">MKTIATDDDRVAVEQTPCMIPDLTIKDLLSAIPAHCYKRSAVWSSAYVVWDFFLLAVIYKAATFLDAFITPEQISLPNAYLYSIGHFAVWALYSFFSGLVMSGIWILAHECGHQAFSESKVLNNTVGWFLHSALGVPYHSWRISHAKHHASTGHMTQDQVYVPKTRSELKMPAFDSNNETLEGSTVSQKVMKELWEAVGDSPIVNAIGCVQYLLLGWPFYLIANAAGQTRYPVGTNHFKPTSIIFAPHQYWQIIWSDIGVIVWALSIAGAIHRFGFADVFRLYLAPYLWVNHWIILITFLQHTDPLLPHYRAPEFTFPRGALSTMDRSLLGDLGSFMGWIGACTTHGLSETHVLHHVCSKIPHYHAWEATYALRRRLDQAGVKLQGRPGGWSEMYRVFRDCRFVEDEGDIVFYKNGHGLAAARPVFADHSASDSGVEIDTNKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFC3</accession>
    <name>A0A2R6NFC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v13094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001296">
        <property type="protein sequence ID" value="PSR71046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFC3"/>
    <dbReference type="STRING" id="98765.A0A2R6NFC3"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000432">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.10, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR71046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="364" mass="40563" checksum="C22E1783C39DA5EC" modified="2018-06-20" version="1">MVKRRQGFSGLSAFVKKAFEQNEHTVDTPPDDPVSLDNGPSTSAVTSQADTSRKASQLEQNDQQTSPDYPSKKRKIGLLGSGLEKYDATGLVPFYTDPSEVPERLSKYFFQRTRYFSLYAEGCLLDSEGWYSVTPELIANQIAERCRCMTILDAFCGVGGNAIAFAKTFIAIDTSPIRLALARHNAAIYGVEDRIEFILGDYISFARSYLTRPSRRRNIDVVFLSPPWGGPEYLTGVQPTKPTSETDIGLQGSDADRVEEQEELHPEFTLSQIQPIHGAELFHISRQITKNIAYFLPRNTNLNEISSLVTHAQTGGFASGKEKEPEVRQERVEVEEEWMGSKLKALTCYFGGLASGQEDMFDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFF4</accession>
    <name>A0A2R6NFF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFF4"/>
    <dbReference type="STRING" id="98765.A0A2R6NFF4"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="312" mass="32463" checksum="38D5C9ED597186FE" modified="2018-06-20" version="1">MAVPTTTQANGCNAVHDVVKPNGVTSSVSLPPTPSESTHTSRSNSPAALTEVPTTSPEENSVPKKKKKKKAKKSSKTKGASDTNKPADENEERPPGPWLQLPVELLESLLVINLDPATLSATDTRPPPLLHSHSHSSGANGTVQRARGFASLADHSPPDSPHSSFANLPPPPPLPAPKPGKATPPPIDPGVFRSVTQIRRLIDEASELSVRASSGLSAAALGSMRGGSGFNQSPWSLAHSLGLGGMGENGNGRNVAMSAMRVHRLRALAVQKLAAAYKADEIASSVMVMQGGSVFDDIAERVLKVGAYLATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFI5</accession>
    <name>A0A2R6NFI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFI5"/>
    <dbReference type="STRING" id="98765.A0A2R6NFI5"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="168" mass="19518" checksum="671A0F7BF201A1C2" modified="2018-06-20" version="1">MLSLRSIVKNLPFLVQALNGSRSQLLQIVQEANYNRLLDVARETYKENIGDIFALNTALTEEHEIPLTLVYQDTGFVFTLKKTELEGELPRGFINVTSKKGKWVFSSVELVRGRIKPFTENQNVTSSAEEEKCKNERCPRRDVDLERQNNSRPRCWNYCRHWSTVQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGF5</accession>
    <name>A0A2R6NGF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGF5"/>
    <dbReference type="STRING" id="98765.A0A2R6NGF5"/>
    <dbReference type="OrthoDB" id="3053342at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7228" checksum="FCB0AEE9FF7BF3F5" modified="2018-06-20" version="1">MEALVDVVKCEGKAAGRALPLWLVLGKDAEEDLRQSCVERLKNLDEWQDITRSTSVDDEASVVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGF8</accession>
    <name>A0A2R6NGF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGF8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGF8"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="76"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="237" mass="25368" checksum="2B9516DAE6A6B7F4" modified="2018-06-20" version="1">MSSDSKVFLDVYIGDRDAHASGQADYEATCALLSKNAAIYGLPSSPADLTEEQQQILSELDSTLEMRFSPPQPLCAGRLVFSLVSSPGLAKTSGNFVALCTGEKGPCKNAPNKKLHYLDCPIHRIVKGFVAQGGDVTRGDGSGGESIYGGKFNDEKEGLKRKMRGSLAMANSGKNTNSSQFFVVLTNDENKLAKMNGKYVTFGDLDSGWEVLDRLDEVGSGDGRPTIPVWIGECGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGW8</accession>
    <name>A0A2R6NGW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001282">
        <property type="protein sequence ID" value="PSR71488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGW8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGW8"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8085" checksum="1555B0C507B10397" modified="2018-06-20" version="1">MKKGFVALTPPGFFVLFLGLSRAMVNFTILAGGYTSFVVSYLFNSDTSSLDVLNQSPTGANPSWLSLHPTNKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH33</accession>
    <name>A0A2R6NH33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001271">
        <property type="protein sequence ID" value="PSR71548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH33"/>
    <dbReference type="STRING" id="98765.A0A2R6NH33"/>
    <dbReference type="OrthoDB" id="2803957at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="423" mass="47443" checksum="D114DB0A2AC26CD1" modified="2018-06-20" version="1">MAPHIQTVNTQCCDNHHYQQPIPRTIPPCTRQHSETPDTPEEETERNPKKRHFDEITDALAGNNKKQKTCSQLDVIRRQSRSLLRFAGFFIDIESIITNGIHLAEDGSQDVELDEEVKDMMPDERDAIVTQYKKIVQLIPSIKEDAQFYREDPDALCDIIRYIQKHAADGRSDDLGTLKPKVLGYLPAKAPSAPPFESLTLSKGERGWAHHQTARLLCPHSLLDEFDIDPNSFISDVENAKIAITADNYPVFLYSDEAQYNPNDIEKNLLRGSYLLAVFRCLFTGPRTATRKTSGPSGGGRPSKAKIYKMTKVTPESIAYAAVLARFSICGQDSWEPQDGMFSLPDFYQAIMDLFDDPTDPWYIDALAWWNKQVFGYDRPSGNTEAQNVIGSSPSSKSHLQQQRAARRAAAAIAPSSPDNIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHL1</accession>
    <name>A0A2R6NHL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHL1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHL1"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000004">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20593" checksum="41D543316C689DA9" modified="2018-06-20" version="1">MSTPPHEEDDFAPSSTPGYKPGGVKNVDELAQLDAEDESLARWKASLGIVPGAAAAVASGPKVTILSLELASPSMPADKTLSMELANPAEMESMKKNPVHIKEGVLYNVRIKFKVNHSIISGVKYIQVVKRSGIKVDKMEQMLGSYGPTPTGEPHVKNFPEEESPSGLLARSGTYNVRSRVVDDDGEIYAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIM3</accession>
    <name>A0A2R6NIM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001208">
        <property type="protein sequence ID" value="PSR72183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIM3"/>
    <dbReference type="STRING" id="98765.A0A2R6NIM3"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="415" mass="44622" checksum="8D45C9FEE2C99155" modified="2018-06-20" version="1">MSTLTSFQNVPAQNVPYFTPAQIPASGTAVPDPDGKPIPSLFKPIKIRGLELQNRIVLAPLGQYSGKDGFPTPWHMAHIGGIVSRGPGLSFIEATAVVPEGRITPEDLGIWSDEHIPALAELTTFAHSQNQKIAIQLAHAGRKGSTIAAWLPQNQIATEELGGWPDKVVAPSAIVHSDGFPTPKELTKEGIQGVVQAFADAARRSVQAGFDVVEIHGAHGFLLHSFMSPVSNHRTDEYGGSWENRTRILIEIVDAVRKVVPADMPVFYRISATDFLETSMPDTESWKVSDTIKLAPLLAAHGVDLLDVSSAGNHPLQSLGPIRTVEAYQSGLSAEIKAAVGDKIIVGAVGGIDNGRLAQRILDEGKADVIFVGRQFQRNPGTVWLFAEDLGVRITAAHQIEWAFFGRGVSRAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJJ7</accession>
    <name>A0A2R6NJJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HbrB-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJJ7"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45443" checksum="32EF8777FB3AB053" modified="2018-06-20" version="1">MHRLGNLAHPPALNPSISTSSNITLSMLPTFLREPDNPWATLYIHILPLFLGEPLRVPIEDLNALVKRHIQSVIPSSPSKALTALESDVGELISNGMLNLASRFREVDDKTLLESVVETWGFFWEQVLPYVEGALLPLQTDSMISSLSRMPKVIKPSSPSGQNGKSGPTYKTQQIDVRTIALQSFRDQIVHPLFPVLHDRLTELREQYPVSSGYQQPRLQHMLLVLVSQRSPPTEQSLTAPPPPPPPGEEAIQILLRTIRTPLVHTTLDNRSHHFGGTGAPSFLSARIPRDRRGRIAHKPDRSGGVYDFIREDDVDGGETPKLGMSFGEPAREKEREFLESLKSPGPEGARASMGGWGLGVGAEEKKVEEDDEEENLDWDQAQAVVERMVGMKNPELSPQPETSRRKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK76</accession>
    <name>A0A2R6NK76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001135">
        <property type="protein sequence ID" value="PSR72779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK76"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="14861" checksum="DA09030A96E0F1AE" modified="2018-06-20" version="1">MTGLCRLVRIYGLNVTIPVYIFEAWQEILTEWFSPEDPYQGFVEKPRYCSWEDLRPSGLLQRHKFGVVLATDALDLGSTAEIVIRCSVSSNSILQNDGSCLTVNNAWEYFFSCGRTKLYPHMSPKDLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK98</accession>
    <name>A0A2R6NK98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v11296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK98"/>
    <dbReference type="STRING" id="98765.A0A2R6NK98"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="8">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR72799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="10608" checksum="46986E385BB5C8C5" modified="2018-06-20" version="1">MAGGAPQDTQPTLPDPNQNAQPKSYIEKFRDRPRTKFVDPCEDAAKASLTCMDHHSYDRDKCSDFFQVYRDCKKQWMEERKADRRAGRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKJ8</accession>
    <name>A0A2R6NKJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKJ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NKJ8"/>
    <dbReference type="OrthoDB" id="2919778at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015361160" evidence="2">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="289" mass="30276" checksum="941FF70D58F51982" modified="2018-06-20" version="1" fragment="single">MPLFTAGILLLLDIWGSKMSGSTSDSARKMVDVHTAMRVLRGLEGRDIMYELANVADSPPLPAPSRPPTSKRGRSPDSSLSTSSLAGPGGFSPDTHRLVAGSMRVSSAIQQQTTRPSNQNQPSAFPCVENASSSPASSIPLSSGFSLPMHGVGGLPLYTTFGAGSTIASGNNGWLAGALDYTHPGSSQIHPAPEETIPAILPESMLGQTFDFVHQASTLVHDQEIANQAASLSSAQNPFPQYLPSIDPQQAPLPIENLDDLIMSLGSDGAMFQDNHGVPSIWSTAPTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKT2</accession>
    <name>A0A2R6NKT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001122">
        <property type="protein sequence ID" value="PSR72977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKT2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7578" checksum="ACE692C52AEA6702" modified="2018-06-20" version="1">MSGPEAIDYLSLTSALDEWCSFEEWWGNVPTLGKPAMVGNALREQAKGVRCQDADISSRSAVTRCLKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL31</accession>
    <name>A0A2R6NL31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL31"/>
    <dbReference type="STRING" id="98765.A0A2R6NL31"/>
    <dbReference type="OrthoDB" id="3253810at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="267" mass="29636" checksum="26ABEEDF1BDD13C1" modified="2018-06-20" version="1">MSNFHLRPVSDKDRSASPSTSTSTTSDRSPRDSKRLPGLPPSQVYTSADLDLSRDTSMQPRKYPAPPTGHELMALFPPAPPINVLSGPTSDFFQREERAFFAKAGKEIVRVRIELDLPLEGDVDSVMKSKPREHSGMPRQWPPNGHPHNPINSPSQLSPSERPPAGQLPPPPTGARGSRGAPVTVTTQPLFPINSHPSPQPPFPPNSNPQHPAFGLRTPSHEHTRSPNQIEHSPEDFRDDDESWRRPMPHNQRRRAGKHTKRVVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL88</accession>
    <name>A0A2R6NL88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL88"/>
    <dbReference type="STRING" id="98765.A0A2R6NL88"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015346597" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="16"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="41149" checksum="75A93A327ECE4878" modified="2018-06-20" version="1">MKAAVSLTALLALVPTVLAGNFSLVQDFSGNGFFDGWTFYGNFDNLTNGDVTYVNQTNATNLAYVSDAGTAIIKVDNTTFVPYNDKRNSVRITTNDYFTVGTVWIIDAVHLPFGCSVWPSIWTKGNDWPNNGEIDIIEGVNQMTFNQMALHTLTGCSAATGTDETGTSGGNDCSVAAGCTVIENTPNSYGQSFASNGGGVWATQFDVTGIFIWFWGRANVPASVTSATDSLDISTWGPPSAAYPASSCNIPQFFGAQQIVLDITLCGDWAGVPSVYQSTCGNGEAVNASSCYLDNVINNGTSQYADAYFELNYIRAFSVNSTAVVGSDGTPVTSTEAGGSPGSPTSSGSGSSPSGSGGSNDNNNNNNNTNGALVGGVSPGRVYAAGVLCALAWILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLS0</accession>
    <name>A0A2R6NLS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001085">
        <property type="protein sequence ID" value="PSR73303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLS0"/>
    <dbReference type="OrthoDB" id="3259652at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="363" mass="40035" checksum="20B56CCB7022F700" modified="2018-06-20" version="1">MRFEPWHTPFPSTETQFPFNENWPAPQIIQSLEVAPVQVWHRGEQETQAVPLLKPESGHETPFEVVGWTAKHLVRSLAFCVKPVLQEMQSPVPSAHWAVELLTVGIKQRPLPEIPSSQEEHPAGHAWQFGPKKPEAQVSQDVPLNPGGHEHVPDAEQIPAPAHGGEHADDCISRIEILLSDEPEGNCDKSGIESQRIRRSVEDGPDATAAHMLSETINDPADVEVESLEALFVGSALSPGYSAIPASSARFNGSENEDELALANPGAKASSAEEEESKTWSNCGFVLEVYCPGSNRTFVGVSDDDKTAPAMRNWISFLLQDTEEIVDVTPAIDMCLHRHIKHTTSTNKPYCWRHVHPVKLTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLU0</accession>
    <name>A0A2R6NLU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001080">
        <property type="protein sequence ID" value="PSR73361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLU0"/>
    <dbReference type="STRING" id="98765.A0A2R6NLU0"/>
    <dbReference type="OrthoDB" id="5297217at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="50293" checksum="09E8FA4F4F3392B3" modified="2018-06-20" version="1" fragment="single">KNGVNRRIVHPSRTLLQKPWYTRYVRHVRETASVGAFDPSLLSDCRTALRMCTNIKSFTWMDDGHDDRHDTELIAYLDILQELRVQELIIRTSSGINAVVWDRLTEIDGLCKVAIWCLNGQPRVLQGWSEKLGSSLTHLELGVSCLSRQHPHFLSQLPLLKALRLKGAPSSSIPELLAVLPNLVVLDTEYFGTGNTRFNEEPVASLRELTVRTSSVDILGPQMLWPWIQKLIPRPSLETLTLNTFSTSGDMTMPRRFLLDLAGTHRLTLKHFIIDTVQLTMEELELLCTAFPALESISCSIAWCDNPDHLGDVIADAHRLRRLKLQVNWLRGPGWVPFGSEHARKWMLRDNSRLRDVTIGRDMFEVNTVIGIMYLRLMVSKPRANGCASRQKMGDITWNLKSFVIKLSIHGYEEQKLYALDGSQYYAILLLRYKSLHSKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMD3</accession>
    <name>A0A2R6NMD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001100">
        <property type="protein sequence ID" value="PSR73182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMD3"/>
    <dbReference type="STRING" id="98765.A0A2R6NMD3"/>
    <dbReference type="OrthoDB" id="2752460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="209" mass="22132" checksum="192A6987BD626E52" modified="2018-06-20" version="1">MALVAVPSHRIQTIHGAFGSPSFASMLPVGSHAQASSFNSLPNVSFSSCRGGRGANLSILAARTAAASAPPTPIVTRPRRPSIRQVPITTRRAAPPPPRTAVASAQDPFADSQHVEVASEPTRASSRPVMVTYTFTRTEGRPEDIEAGCQCSTQPGKWKALEEEASIVRGGKALCEELLIEGGRGRVLSTGAAPKELRRLLPDIYDVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMI4</accession>
    <name>A0A2R6NMI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMI4"/>
    <dbReference type="STRING" id="98765.A0A2R6NMI4"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="363" mass="42374" checksum="D6A5100476D85479" modified="2018-06-20" version="1">MVETPRLIALRAEAAKFQEQLNVYEIRWRDRQVFLASQGYMLRPRYRPGWVPSWKTDTSRHPRKNEDYWDLPLREHLIDATRISDGRLVYVKRVKTGDTESTIARMLSSSRFSEDPRNHCVPILDYFADEDDTTIAYMVMPFLRLTDDPPFETVNDIIDYGNQMIQGLVFMHEQQVAHRDCSEKNIMMDADSLFPKGYHPVRSNYLPDACTLAPRLWRAKGHIKYYYVDFGISVHLPTDSPKLVVGGYGRDQDVPELSFDVPYDPFKVDIFILGNMFKREIYDNYSNVDFLLPFINAMTQNDPKARPDAPEAEKIWGNICAKVSGLQRGWRLRGRKEVWVQKVVLDTYTTVRRIFGWVTDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMP9</accession>
    <name>A0A2R6NMP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMP9"/>
    <dbReference type="STRING" id="98765.A0A2R6NMP9"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="194" mass="21921" checksum="AEFF8250F96D3F22" modified="2018-06-20" version="1">MLWGSKQLSDFDSLVNPGYASQLLFINEPDEPTQSTMAPGDAATLWKQQFQNRAGEGYDLWSPAVTSSTRGEAWMDQFLTACDDCSISHMALHFYDTNPQNLIDYVTHWHSKYGRNIVITEFACENFGGGAQATMDQVWSFYQTVMPWLMSQDYVTAVFPFGFLEDMANVNPDNQLMKGGQLTDLGKYIVYGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNW4</accession>
    <name>A0A2R6NNW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NNW4"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="256"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1959" mass="219344" checksum="06DCC64231D1078B" modified="2018-06-20" version="1">MVSILVDEVGDDVSPQSDKWRRWTSLSATGTQSTTAPDQPIAVYYLSSLIPPLLATILEHVDLLAVDDTTSVRFHRFFHNLIRSKPDTYLDLLSVIAYHTPRARYASVGLLSSYWPKAIGHIVFSKQLSDITSSESRSLSQRRSSVSRNSPSAHGHPYAHQFIPWRFGPPLRPVLFDGLSPNTCRVCFLAIEGFGLLCPFCMCAVHFDCYDYPDGSFFTQYPMATDRDIQKVSVHRFCHVLPNTRDGSSSVVSKQQHVFRMVNIFSMSLCFICHQPLWGYVMQGLKCSSCRQFVHSSCLDTTPSSKIARCRSVVIDSTAVTIAYSALRRSFVEYYKDSILTEVDLPHRSHEELAVFYAILWCQLRLLDNGLALGSIVIVSDSTGDPEEEGVAEEFELHYLVELYESYLSLGRLPVSDTLADYLAENGLRLQDCSIYFDWNVLAFFASTIKIPCTSEEARRSSELLGVDQLEPHDDSGTESSQPYETMTLGYLRDQLGDTLNMFSDTAARRLLSHLHHLGLLHRMDGNLLLLDGPSPAKLQCCFPLPFGFDISVDVETLVATIEACLSDINLSVNEIGLLQLIRRFWPNGMLSDYTFRRLAKAALAWILSEDNNLAVILREYVAKGSSLPGVRGGESMPWPPQTQLRSSTSGAASNGGDYVATRRALLAGYVAPWLLALHDQDIVAYAALVYELLSEYAEEDATHHPYFVGEITEKEEEKRQNVITDKILRLIVKACQTSIVFTVFDDLFQRWLERAQILENYTQPIPSLPRLFSREGDGSQRHTIMIDARFSVGDLSALANANPLQAMMNIANSNQDGFRRAIRWLCLFASSGVDIPVQTFLHFGTLASKMRATLEDCSLLIEATLYSSWLRSVGRLDLQTMIGAMHAKLLSEILSKLQASENVSEIFIFIRRSLATCLLLYGCERKYLSKLQMIEEDEIENLPSRRKLEARASTMTDPIIIDTKLMNALGSYIEKRVIGLSCLVAKFLNAFVNQTSLVESYEVDNFILRNAATLCSCIWEFYGIQSPELSSIRPALLVRVLVVDAQPFQSLLVHHLDMKTGWEVRLDTVLRLFRIILDVINPAFVVEDRQWGPNVIDVFHHFFTSMWLDEQEEIRTAVDTWSQTLLPAHFEAIARCWDEALSKSPISERVKLVSFLSQLRSHFPAWRVLMWETIIEALLENDFMQKGDEDGPAAAHLSLYGLSSDEGQPTAQIDPELILLRVGLISLSLRMIADGISIDTFSLLRLKDQIARALGFQDVTLVPSSSGHTFHIRFGDTSGIPSWAFPSITDLMLVLDSAHPYDLAASAMGGPYVDDDSPTTLLVGSAFVDLVLGLFTHTADLASLPPLTLKNLIKGLLIAIQKHDFDSRPLRHLQGDLRKAIRLNLFTLVIENSLSYDLRQLAFSATQAFIKRCPTMVGNFVFEAMLEVMKLMVTLDYEQKAEDLLVLQATVFLETILQMFSMSGIMAMLFKKRLEPNFFRVLRHVLDSSAKSTVLDGSKENLREILLRDTLSRVIDSDVESYQTAVQNLQDYVEIVYHTAYNSDLMQCVGLSLTNIARKAADWAGEAFDASPTLLICCTLIHYNKSQSRELVLYLETLLRATLVRFRVTAACLTRLLQVTSSLYRRRDTQEQQPPINVFAVVLLEMLSDALSAKCRLPHSTLAAAVEIVMSNTGPLRLSSEKLAELAACGIYSFQMGCLPDSQPQDFAVSQAVAKMVLQIAEQQPSVLFNLNKRPLNVRIWNLILLAALSLDRTGGATLLLDYFQSFTQAYHSSLILTQSAAAGYSGPEDVDISRAYISIKLWLLLSHKAARNDFDASGQENDRENFLSRMIWTELWPPFEAMIEFLEGGGPSNSSLMLASASVADLFLFLHQSRSILTLEWPAQMSVLARLRAAGRAESKISRVLRSINEAPPDVAVDFFISQTATEIAAEERLLSETAKLQDLAKSGAEKGRRIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP52</accession>
    <name>A0A2R6NP52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v9991</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP52"/>
    <dbReference type="STRING" id="98765.A0A2R6NP52"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR74247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="46339" checksum="35AFD5A507E2CF60" modified="2018-06-20" version="1">MTFDQWWFHGHLDHPPNDGDVFQLPAGQAATTELGCNKGATSFFASSEGGDIRNGNDPCPGSDMSEWHTTGIDDLFGCSLAIAYKSDVTQVQPEDFTVFSVNQTCVWTRFTDFQVPAQMPPCPEGGCICAWFWIHSPDSGGEQNYMNGFRCNVTGSTSSVALAEPQVARRCGADPANGKMQAAPGNCTYGAKQPFYWFQQERNNMFEGTYAPPRYLDMYNFKDGSQDDIFQDSYPNGLPVPSPNSTVVPTPVLGGQAVVQTVSPTSLSTASLSSISPAASTASSSLASSTSIATTESSSSLIPSSSLPPTSVSVLFSTATVFSTAIVTVTQTAVPSSQPALSSPTSTVTVVNTVVVFVTETDAANVPSVTQVTSSSTIFVFATNAASTELPTSVPSPAALFVGNESSPPAFAQLENIDESGAAVDTTSSLPSAPTEQTTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP62</accession>
    <name>A0A2R6NP62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10131</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP62"/>
    <dbReference type="STRING" id="98765.A0A2R6NP62"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015346583" description="Protein OS-9 homolog" evidence="9">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="156"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR74175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="472" mass="53327" checksum="D0E656C1DD6C2D2D" modified="2018-06-20" version="1">MRLGTLAVSILPISLWTLVAARLQHHSLVPEDPYAFPKYRVTFLHGLPVPNNTAQKWLQSGLHGGELEFLEQPWEEDHRWRTPSMKSIDDGTDHEADNTETNVSNYKLELMKMGPRTSYLCLIPPPPVETSPIAAEDPSTDITPVHTWSLLQPLSGTCLYHRQAWFTYSYCHNSHVRQFHELAKPQAHHPGEYRPEEDTAWEAYTLGRAPPTLEPGADLTVAQEAALAANVELARNAGSRYLVQRWGDGTYCEKIGRKREIEIQFHCSMTMTDTILFVKETQTCHYILHIATPRLCGEPGFRSRHDAHEQTNIRCREIVSSETYASADRSLPAADGPFRMPKRAPKPVIAPPPEEDKDKQEKALLTQAQHETLRKAIETLMANGELKAGEVIIQPFGEGDEEFVVEFIDYLNGEEDEEGTLHPQAPSLDEILRAAGLLDSKGPKKQPDSRDQDREDDEDKKTAKEPHTRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPR2</accession>
    <name>A0A2R6NPR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPR2"/>
    <dbReference type="STRING" id="98765.A0A2R6NPR2"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="439"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="653" mass="71385" checksum="DE91A3398049C4CB" modified="2018-06-20" version="1">MSKIAPYGTWASPLTANAIIQNAASIDDVIVDPVTSKIYHVENRPSEGGRMVVVKTEEGIDVVGKDWNCRTGVHEYGGASATAYGGHIYFSNFADGRVYTVEDGKEPKAITPESKVHRYANFAVHPLHRHLLVVVQEDHTHPAPADVVNTLCTVDSSTQTVSSLLAGMDFYAAPSFSPDGSHLIWVQWSHPDMPWDGSEIYIASVQTEDHKLKLENIRRVAGQKDKISAGYPTWASNDVVLFTSDESGYQNPWKYTLSTGTATAVLQTPVKEDFSLPAWFLGGSYGAPIDKEGKMAVCTALRNGRSVLYVVSLLSGTLEEIDCPYVSIEHVRHVVDDVVVFVGAKDDAPPHIVLCAIKDYSKPKFSVLQKETAEVKPPIPSSYISRPVPLTLEVPPNGEPLYVVFYPPTNPEYAVPGDEKPPCIVNVHGGPTGVATQELSLTTQFFTSRGWAWVDVNYGGSCGFGRQYINRLQGQWGIVEVRDCALSASVLAQTHSLIDPARTAIRGRSSGGFTVLATLCAYPEAFAAAASLYGISDLQKLDEFTHKFESRYCEKLIGGTFSDVPNVYKERSPINNADKIKSPLLILQGSIDAVVPPQQAEDIVKTIKENGGQVEYVLFEGEGHGWRKAENIKAALEKELAFYEKTFGLNLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPS8</accession>
    <name>A0A2R6NPS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPS8"/>
    <dbReference type="STRING" id="98765.A0A2R6NPS8"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="20685" checksum="193666A4A961435E" modified="2018-06-20" version="1">MQKDEEVGKVAQATPVVISKALELFLGMIVDEASRVTLDRGSKKVEAYHLKHAVETVDVLDFLKEIVEAVPDPSAGGTIDLVAEAAERAAAKKKAKTRKEPEPKLEDGESTTPKKRKKKEEGVGGEKGKGKGKGRGKGKVKEEEGEDEEGGPPAGEPSSAYDMDQDDDEPENGGREAYGRGVHEEDDDDWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ37</accession>
    <name>A0A2R6NQ37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000973">
        <property type="protein sequence ID" value="PSR74651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ37"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ37"/>
    <dbReference type="OrthoDB" id="2740399at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18112" checksum="10A73772157A5238" modified="2018-06-20" version="1">MGRCRRPSGKTQSGIDDNINWEARYSQACDDIKTGKFSGYAEAARHHGLKYQTLCNRFLGYHRPATQAHQAQQILSPAQEEVLVDWCIFLGLTGHPVHKKSIRFKVKQLSGRDVGPKYINAFLKRHKKDLRFCKPAGLDPKRAQAFNPTAVHEHFKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQK9</accession>
    <name>A0A2R6NQK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQK9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5542" checksum="4D196DF5BCAF407C" modified="2018-06-20" version="1">MPGWPIPEPLSQHCIEGPELRRLPAETAFWADGMAVGLSQNTHIVDWTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQR5</accession>
    <name>A0A2R6NQR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000943">
        <property type="protein sequence ID" value="PSR74942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQR5"/>
    <dbReference type="STRING" id="98765.A0A2R6NQR5"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015347506" evidence="1">
        <location>
            <begin position="22"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="214"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="561" mass="60014" checksum="84E0256CB0FBC5D9" modified="2018-06-20" version="1">MKLLSDVLLFLVCTGLWAVHAQVSSSGRTVVLGGQTYFVPPSPVAQFKFGAGIAVKAQLEGLAQGGSVELIPFSLIATASKHFSTGQLQETVSLYQSLDDVWSPSFLQGIYLSFNGSGSPTATLSTGEGTKIVVLSNSYAFGVPLTKALPPGPYFVEPLTGNIFEAWLLYSDENQSFLYGTVADGKGGFTQLSAHIDGAATESVAVPSRLYFEATPKQPLAGARLAVKDIFDVAGLRTGCGNRAFYTFNPPKNTTAPAIQRLLDGGAILVGKVKASQFANGETATDDWVDYHAPYNPRGEGYQDGSSSSTGSGTAVAAYPWLDYAVGSDTGGSMRGPAGANGVFGNRPSHGAVVLDDVMPLSPELDTAGIFARDAKTWQKAGLWWYENFTSFSKFPKTILFPVDSFGSSFLTNPPKNGTANAMFNTFIQKLEAFLNTTRTEINLTNLWTETSPLIANVSNPPPPLRTMLNTTYADLISLDQIALVADPFIDGFKAAHSGQNPFIDPAPLVRWDYGRSLNDPNRKAEALNNKTVFMNWFQDTVIGALEGPNIGIDSIRTSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRU1</accession>
    <name>A0A2R6NRU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v9027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRU1"/>
    <dbReference type="STRING" id="98765.A0A2R6NRU1"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="12">
        <location>
            <begin position="40"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR75547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="291" mass="31317" checksum="A539BC3BE7C50760" modified="2018-06-20" version="1">MSSSDEESVEEHGVPSIADPSVPLTASYTYHSPKPTADGPYILGVDEAGRGPVLGPLVYGVAYCPASYHDDLDKLGFAGLLPSHVLSLVAYLKKLIDSKTLNARTRSSLLETLCSDPENIAWSVYVDALGPTKAWEANLSARFPGINFTVTAKADSKFKIVGAASVAAKVTRDAWIEGWVFEEAQSCSSLAANARTWGKEIGSGYPSDPKTQAWIKSSMEPTFGFPSLVRFSWTTVKVVLEKDAHAVTWQVFDMTDDGQASLIKAFESATGRDKDRCAVTKDLGIKSVGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRX1</accession>
    <name>A0A2R6NRX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRX1"/>
    <dbReference type="STRING" id="98765.A0A2R6NRX1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015338003" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="330" mass="36091" checksum="0B04A6AA1991092A" modified="2018-06-20" version="1">MPRVLTFFAILVPVVAVFLVCRSFDVAAHLQLSWPLALHPDSPVDDAQFHVDVPSAGVESDSGVLGHGIVVAEIGDDAAKHQFRRRVVAVGDLHGDLPNAHKVLQMAGVVDETGQWSGGVDFFVQTGDIIDRGDDTIKLYDWIDQLRGEAKAKGGVVLSHLGNHEWMNVIAQERQKMLMTGRIGKTWAGNYTTTSRLPLHPSLGPPNTDYDPSLLSSLSHAAVSFVHGGLAPNYPDLTPFPSRINNLGHTLLRKLQHRNPPPAPHPPNPYPGLPHDATPAEHRLYGTDGPLWYRGWALDSEAKACKAVDDVLQRTGTRRMIMGHTPDFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS52</accession>
    <name>A0A2R6NS52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS52"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="15"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="302" mass="32949" checksum="1C6A4E736F1A710C" modified="2018-06-20" version="1">MSQYTRIVLAERPQSEIDSKTFRTETVPFDLRPNAKQILVQTIYLSLDPTQRTWLNDTRGYMKPVQIGEVMRSGGIGVVVQAGSGSCFKRGDTVFGMLGAAGATGSVACQLGKKAGAKVIAIAGSKEKCDWLEKELGVDKALNYKSPTFRKEFIDSVGYLDVYFDNVGGDILNLALSRLKKNARIALCGTPLVIVRDATMLKPSFVGAIADYNSKPKGLTNYTTLITQTASMRGFLIFDYAQQFHSARQELAKWLAEGTLKRQFHVVDGIEKCPQALPLLFSGGNTGKLVVKVANIKAVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSK1</accession>
    <name>A0A2R6NSK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v8913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSK1"/>
    <dbReference type="STRING" id="98765.A0A2R6NSK1"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR75796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="473" mass="52912" checksum="F681F80A2F1A825B" modified="2018-06-20" version="1">MSNASHNRNHGIREELVHRSFDRTFARLYVQMCQKQQALRLRPVARQYMPRMDLFDDDSQPNISAMLELPGVAREHISVLVRDGKLVVHGERGSPLSSRLQTGSASSRRDADPPSRNNHMAVSAPPNPTNYRVRELKFGSFHREIELPAGTQGVDAILAILDKVELAAREIPPVDNKASRFGNPAFRTFYDKVDEISPSLHESLPGLPKEAIVEVSAYFREAWGSRTRIDYGSGMELNFLCWMLCLERLEVVTKEDHVALVIHVFWRYIQVMRVLQSTYWLEPAGSHGVWGLDDYHFLPFLFGSAQLRGHKYLRPKAIHDSEIVEEVSKDYMYFACIQFINSVKTASLRWHSPMLDDISAVKSWDKVNSGMLKMYSAEVLGKLPVIQHFLFGSILPWDGPLLPTPSGEDEDDAHRGHAHTQGGDLGGAGQREVGWGDCCGIPVPSIFGAAQAGEGKAPGPRLGGPNIRPVPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSY6</accession>
    <name>A0A2R6NSY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000861">
        <property type="protein sequence ID" value="PSR76112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSY6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8726" checksum="0F4306200B55524A" modified="2018-06-20" version="1">MTGFSDVENYLRRNNEGIAEETSALLASSVQGVAGYLGEFERRLLWWERVDKDVLELKTRDKIHSRIFQDLWHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSZ5</accession>
    <name>A0A2R6NSZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000861">
        <property type="protein sequence ID" value="PSR76115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSZ5"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="15428" checksum="3870965476140B48" modified="2018-06-20" version="1">MNTLGLSTTAINKIVNNPTVLGSRLSDRTDDTLQLLGVSRADADHILDGYNNGFRIVFILNATLAAIATITSIVMIRHKELTRGDEEQLREKALKEDEKNNRAIGEEDREVARTEDVELDVLPVLQDQERARSEAIATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTA4</accession>
    <name>A0A2R6NTA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTA4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="502" mass="53273" checksum="927572873F9D7DBD" modified="2018-06-20" version="1">MAQAALLNMKGTQLHPQVQDPRIPSPSFGLSPPMVSNLTLAPDAYLQANLRPLPPPIGLHHSGNLPLATPDLSSMKSTHLPQYDGFNAQAADIAGSSLRVPPHMLGFDADSALTREIDVLQMKLAAMGLGQGMSGSAARAQEGYTALEQLILQAHAQQQQVPQSHRQDPSQLRNRALELNAAAAEFNPPSVGIGRIPVLPRTRQGGARVAEYLSPMSEEDFHSTARGHRQALADDLNPNSQQKSDRGVARLTLDDDSRLSFTRQRNQTHAEARAQAGAQAQPLHTRSTTVPSHYLGPDRNGSQNFLPPRPYNTNSSNRSSINTDNTNSNHTPNSLGNTAKNTSYHGIGTNSFTRAGNNLNMNSSNGLGNDILRDNSSNLTATPLSFSKPHAGDTDSQRQQHTHIDLVANTNRGSTLPRSGLSNDADDEDEGSGADSPGLSYSVRTPASLSPATPFSAFGETFDGPPMTAVKVSGPGGEIGLGMPVGVGVGMAGIQQKIEMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTD5</accession>
    <name>A0A2R6NTD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v8555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000850">
        <property type="protein sequence ID" value="PSR76323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTD5"/>
    <dbReference type="STRING" id="98765.A0A2R6NTD5"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR76323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="158" mass="17371" checksum="3F93C6B8604F20D3" modified="2018-06-20" version="1">MSKDPLIGGAIGYFGQPENYVWFKSFLVLEAIFQLPVFFLGMRGLLKGNERFTSILGINCRAKRDTGSRSIYVLILIYGASTTTTTLPCLAVVLATPLTNAETIAANLISITSTQRLLLLSSYVPFFLIPLLMTADMAFRILDIMKAGIRAKDAVKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTN0</accession>
    <name>A0A2R6NTN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000846">
        <property type="protein sequence ID" value="PSR76432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTN0"/>
    <dbReference type="STRING" id="98765.A0A2R6NTN0"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="15629" checksum="AB97B640C56D1ED8" modified="2018-06-20" version="1">MQEGKLPISKLMPLDLEHSFLAYLSACETAKGDLVEPDQTVHLAATMLFTGFKSVIGTMWYVDPTLIMCGILLMECDRLMRDDDGPTVAKVVYKQLFSQDSENLALDPDDVPYALDDAVRKLRETGCPPHRWAAFIHLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTW0</accession>
    <name>A0A2R6NTW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTW0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6628" checksum="2DCCAB6A4A4DD207" modified="2018-06-20" version="1">MVVRDLLLVTPDIIEEILNNQNSLIPDKPVITLCGWRNINENAQWMIMSIPLKRRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU62</accession>
    <name>A0A2R6NU62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU62"/>
    <dbReference type="STRING" id="98765.A0A2R6NU62"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="187"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="311"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="421" mass="46087" checksum="779989237EE897AA" modified="2018-06-20" version="1">MTEFVSPHAGLPHIPDDLTIPQFMLDSWHPTRPIKQGLLNPWLIEDATGRPVGCEELKVTKSSILIAHSTSLAIAEKAAHGSGIPLARIIIIDTPPTTAIAINSYHTLDELVREGLGKFPTFTERRLEPGEAKTKIALLNFSSGTTGRPKAVAIPHYALIANVVQMAFFCKAAVDYTSKEQQRYRPGLVAIAGMTETCTTVTFPRIDQKIGTLGSGGQLLPGDVARVMKPDGSLAGFNEPGELVVKGPSVSLCYLNNPEATKETYIYFDSKPDRWIRTGDEVMINEEAELFVLDRIKEIMKVRGFQVAPAELEGLLLDHPDVDDACVVGIPDEYSGEVPLAFIVPSPKALGRMKTDPGEVEKVKSTLTKYVADNKVNYKRLAGGIEFVDSIPKNPSGKLLRRFLRDKAKEMMKAKQAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUP1</accession>
    <name>A0A2R6NUP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUP1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7755" checksum="BC7FA98F43F2B550" modified="2018-06-20" version="1">MNILALLNYEMVQRICIQVNVFRDVPEHPDMFKTVLDNCLVPDPEVRGFFLSPLKGWNEDPSLHVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV46</accession>
    <name>A0A2R6NV46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000796">
        <property type="protein sequence ID" value="PSR77376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV46"/>
    <dbReference type="STRING" id="98765.A0A2R6NV46"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="279" mass="31496" checksum="7D9DE57D55B071AE" modified="2018-06-20" version="1">MAPETGRIGPYIILSQWVMERLIGELVGELRQPSNPYQNLAERAFRRAQVSALKNMYADLDPIKPLPRGALALSNNNYTLLRTAELSSRLVPSHEACALRTFGISNQAVFNFSLEWIENPLVAKWARLWLPNGQIARSKWYESRRPNPRISRNVKLASIENRSQTAYAEVQYYFKITVNGISHGFAMVKMYDEPDQSLLKLSSNTVWSCKRQKTFKVINVSSIISVVGMVPHTRADGQLGDYEEGPVFRVDKMGLDAGVLTGTIEFPEPDETPVHTQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV61</accession>
    <name>A0A2R6NV61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000795">
        <property type="protein sequence ID" value="PSR77392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV61"/>
    <dbReference type="STRING" id="98765.A0A2R6NV61"/>
    <dbReference type="OrthoDB" id="3265112at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136329" checksum="419A371166CE69B0" modified="2018-06-20" version="1">MAPSERQHQRVTSLLGPQFTSPKKRKRPTARSAQESVVPLGQATRLLQLQSRLHALLSPTQPESSISAQSEPTGDSNGHLQPNIERNDGSADDLGAHDHVPLPEAANTTSLKPKRRNVPDEKARILYERWETLLASLEHPFLHYLNKTSRVPTSTSFSRDGGWVCQNPLGCTRTEHAVVMLFWDHFETRSVSSCLCLSLPEILVSNGMFPTSPIQPGMAVSINFLEFYHHLFWRSADAVTAIAAALRTFYSHRGWDVVDKMGRPVKDPFHKGLGYAIQWYDMLRVRIERGVDQAVDNARLFFKVHCESGENDKRSSSAGPPKTTANVHDNPPRLSALDLETHPVSTPPKTNDLGTSFRIVDQSLDECAQILKARCAACFGGTAFGIPVTSHRHLRSAGDSPAFYEPSLILPKEFVDAVGVRIEQMRRKPPKPNYVPKVPDSAVDACEHGHEAANGNKVKTADGRFDDAGLMALICRHDIPLFLTNVDTPGEQQKYAIALIQHLFTLIPAEATVKALYDIGCVLDRSLNLRSRRLWIVDRQAAAVGENARRNLGATIERHLRNSTKQSTIASADLNMCGFSESQLLKQWELQKEDQLSIRKHAPARLKNELDAVLVLHAEVDKLEDALKIARIHLQASDAPSAVLSVISQLQVNQSIISERVETLYTSLNVNHIFPDLGGLPVDFVRVLLAARDIKISVRKRAIANFMEWDKLDQAAGGRDVALGTKLHQETRKKISKRKPALITAIKKFNNYCEQLHTLCPVNTRIHIPEPLPIDLVALRSHPRLMEDVWIAPAVNTPPPLWLEDANIRTGIIAYHKNARCKEERMRCKTEAENMCRWFFEELTAIEVALQLPENEVYKTQLRQRRAQHIHLKSLWRTSLVSEACYDFHIASARSIGEQLFGLFPEATVSQIPIELCHEEADDLDDSDDRDYLDDRDYLDDRDDLDDMSDTLPEDFINSVDGILLTDYLEDEVADDPNAVEIARDTGSLDIPLADVVCMAADLPNVLRSDDWPELCNVRWTPLRTSDLSQSRHRPAQGTCPSVFFHSDDIARLADPTAWLNDVCINNCSVLLREEWQHHRPSSSSCAVFSTYDISLIHSGAVDALKRSVARSQYWEHNVWIIPIHHPDHWTLAIIIPSIRTIYQFDSQANQATWQSDVTPVACQTNSFDCGVWILAAMASIFRGFETTGIQEVHISSFRRYLLYIVLQLPCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVG3</accession>
    <name>A0A2R6NVG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVG3"/>
    <dbReference type="STRING" id="98765.A0A2R6NVG3"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7001" checksum="1B0DC735D22FBE49" modified="2018-06-20" version="1">MHQSTRSPRGDILQEGDLVLTGTPSGIGPIVEGDKVECLLSDPTSGKILASLNFGAVNRVAGYSYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVH7</accession>
    <name>A0A2R6NVH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000808">
        <property type="protein sequence ID" value="PSR77210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVH7"/>
    <dbReference type="OrthoDB" id="2804135at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="330" mass="36812" checksum="EE03B15E51900E6A" modified="2018-06-20" version="1">MDVSVLASSSEMKADSNLRGPLANGRRRVHEEPPRPVLNPQAIVVPAAQPTAVTVVVPAAQPAAVPVVAPAAQPAAIPLVVRRRGPATGDVPLPAIRNSMAIWKVRVVPSYIHFVATLTNPWDADSTEEEIDALQQSWAAWFPQHNVLVTPGSAIYKVAVQRLYEWRSGIGKKGVVAVEWFWKERGIDTVQARRKYVATHLQPGFLCMYRDDTVERGFLLYQTGKIQSEQEQKDDIQAAMLEGDTDLAKELKALHVRLRTFSESSWGKPTQEYVQAITRLSSKRWEWIIKEGLKYCVKHSKALLQIRAMGEQDDRALMIMDNDDNSGNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW45</accession>
    <name>A0A2R6NW45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000760">
        <property type="protein sequence ID" value="PSR78069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW45"/>
    <dbReference type="STRING" id="98765.A0A2R6NW45"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="266" mass="28749" checksum="A27851B15036F1FA" modified="2018-06-20" version="1">MSCSDCVRGKFIANLRVALKGLITDNYLGVLHEGVAEGKFEQIAGVACYVATPTGDYAKGKVVLYLSDIFGLRLINSRLLADGFARNGYKTIMPDILNGDAIKDLNDPSLDIMEWLSRHGPETWTGSVDNVVASLKAEGVTRIATTGYCFGAPPAFYLACKNESVATVVSHPSHLKCPEDFEKYKAESKAPLLINSCEVDSQFPLDQQAIADDVLGGGKFAPGYERTYWDGCVHGFAVRGDLSDPKVKAGMEGSFAATVDFFKNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWB0</accession>
    <name>A0A2R6NWB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWB0"/>
    <dbReference type="OrthoDB" id="3209295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24013" checksum="386FB48F912CC971" modified="2018-06-20" version="1">MENIFLRYSEVVERSPMLLTHVCRLWRQVALSSGRLWRNIILSPPERAKHHMKLSQGCLLRVAWFKWTYKIKTPPDFSWIQPYSPRFEELLLVHQPDSIAAVLDSLGPLPQLLNLTIIAPEDNPFHHSLSISFSQAKLISVDMPSLQILVLTQDDPILPSLIITLHFVSLRRDTGRPLKHIKLDNCKYTEGDLAALQTVAYDALEVNCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWF5</accession>
    <name>A0A2R6NWF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v7475</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWF5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWF5"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000009">
        <property type="entry name" value="Phosphoglucomutase, cytoplasmic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="185"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="300"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR78279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="565" mass="61623" checksum="12985607C58EE513" modified="2018-06-20" version="1">MSFPVKEIKTTPYDGQKPGTSGLRKRVKVFQQEHYTENFVQAIFDSVDAKGQTLVIGGDGRYFSPETVQTILRIGSANGVAKFIVGHNAILSTPAASNIIRKYKAYGGILLTASHNPGGPNNDFGIKYNMSNGGPAPEEVTNKIYAKTKSISSYKVIESDPVDLSKIGSFTYGPTKVDIIDSVKDYVELLESIFDFDLIQSFLLTNSDNFKVLFDGMHGVTGPYGRAIFVDKLGLPLSSVQNAVPLPDFGGGHPDPNLTYAHELVENVESRNIQFGAASDGDGDRNMIYGKGAFVTPSDSVAIIADWAEEAIPYFKSGVKGVARSMPTSKQIEYVAKKKGLTCYEVPTGWKFFGNLMDAGKLSICGEESFGTGSDHIREKDGVWAVVAWLNIIAFANKKSPNQLVGIKELLQKHYALYGRSFFSRYDYEEVSSEGAQKLVDNINEHITKDTLLKTTHESKSTGQSFTVSETVNFDYTDPVDGSVSKNQGQIIRFSDGSRVVFRLSGTGSQGATVRMYVERYVAPEKGAAVLNGDTAEGLKGLIEVALEISKLKEFLGREKPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWN5</accession>
    <name>A0A2R6NWN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000742">
        <property type="protein sequence ID" value="PSR78426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWN5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWN5"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="432" mass="48823" checksum="C70C1F06952E64E5" modified="2018-06-20" version="1" fragment="single">MSNLRAHEEQPRHQGLSNVYAAQVARAKAQSPPAHNINELDKVATEEQLEWDYWEHQTIDSSFNDGGTAPPDLKLKFMESVLATLRHSAQNGENLAGKDLLNKHAVALGGAMQGLNIIEAALWPHDEAPLPEDGDEIEAEFEDALLSHTPSPQKIAETFFGARNTTDDAYFPYPNKAIMKTDILFSFPRLQFSRAQREAVLAWGRDLGANNVPSLYALEKFQVASLQAVGNPTVKIEVASGNILYMNDPAELLKKLYAHPETRSKIHSLPELTPNKIKEVWQAEKWLYKVPNELLTPMIRLQNKDFYVQELVYCENKKWFIPERFFKYKGLKYAVGHAVKTSSVGYEISSSAEYAKRMPNPDRKLAQGLEWECSPLVLFIDDVSGNSTKQWNVHYSCYMSHGGLPWSEIEKERNIQFVSTSPHALPMEILQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWY5</accession>
    <name>A0A2R6NWY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v7350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWY5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWY5"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015363127" description="GH18 domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="61"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR78603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="469" mass="48729" checksum="24D189AEC5BEAC6F" modified="2018-06-20" version="1">MLHMLSLPLLALNFASAWAAPMCSLRSATATSSASTTSSTSGSAAGGTTTSPSSSGGNTTRNDDIVATTWYAGWHSQYLAPADISWSKYTSVTYSFALTTPDVNTVSLNSDDEQLLPQFVEAAHNSNSKAMLTVGGWTGSQYFSSAVGSADNRTAFVNAVMGLVSTYNLDGLDFDWEYPNKQGLGCNIINAQDTPNFLSFLQELRTAAPNLTLSAAASIVPFAGPDGTPSTDVSEFAKVLDYVAIMNYDIWGSWSSSVGPNAPLNDTCAPSADQQGSAVSAVQAWTTAGFPANQLVLGVASYGHSFHVDQTAALASLSSSPSSASSAQPAGTTPLAAYPAFDASQQPMGDSWDVSAPAGVDQCGNPSPGGPSGIFNFGGMIAQGILDQNGTAVPGMGFLFDECSQTPFVYVPQNQTMISYDDPQSFAAKGKFINEAGLRGFAMWEAAGDYQDILLDAISNAIGIEEVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX77</accession>
    <name>A0A2R6NX77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX77"/>
    <dbReference type="STRING" id="98765.A0A2R6NX77"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6120" checksum="F061E0F49F83D5CA" modified="2018-06-20" version="1">MTTPHVIASSSGHPSSQSATSSGVVGQHFRVGKKIGEGSFGVVFEGMFRQFFMLKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY50</accession>
    <name>A0A2R6NY50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY50"/>
    <dbReference type="STRING" id="98765.A0A2R6NY50"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="214" mass="23604" checksum="C6100D3DCDBDE797" modified="2018-06-20" version="1">MIERGDWQVSDIARNAFDLEGKVIGTIGAGRIGYRVLQRVLPFGPKELVYYDYNALPDAAAKTVGARRIDDLKDFVSQCDVITVNAPLHEGTRNLINADLLKHFKKGAWLVNTARGAIANAEDVAAALKSGQLRGYAGDVWNKQPAPKDHPWRYMKNPLNGGNGMVPHYSGTTLDAQKRYADGTRQILENYFNNKPQEAANIIVGKSKSCAYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY59</accession>
    <name>A0A2R6NY59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000680">
        <property type="protein sequence ID" value="PSR79869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY59"/>
    <dbReference type="STRING" id="98765.A0A2R6NY59"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="265" mass="29543" checksum="7D236115CD68F2F5" modified="2018-06-20" version="1">MAFFDLVTFRWGYTNANSTFTLSPTVLKAFPEPYAERGALIEAEERDSRLDTPIFVCQLSFPGMPMMLHLFEPRYRLMLRRCLATPNPCFGMIPPPRPSSDPGSPGNDYGTMLRIRNVQMFPDGRSIVETVGTCRFRIMERGMLDGYIVGRVERVDDFEEEVDEGGSETTVEDALAAPSAAASGSSLPLSRLISSTPRRTGNPQTPTNDELMAICRGFLDEIQAGTPWVVQHLHVNYVAQPTDPAQFSFWMALVSFSFVSFHIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY78</accession>
    <name>A0A2R6NY78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000680">
        <property type="protein sequence ID" value="PSR79868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY78"/>
    <dbReference type="OrthoDB" id="3214861at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8390" checksum="6CF3B175ADCDFA79" modified="2018-06-20" version="1">MSSCSFFDNSLKKLAGNAWAKFAALGSAVGTDVLIAASMCLMLAIRRTSFSRQAVAFVRNLWKVSDVPKGPTRWYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYA4</accession>
    <name>A0A2R6NYA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYA4"/>
    <dbReference type="OrthoDB" id="2803755at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015362148" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31001" checksum="A0CFF2E6C558067D" modified="2018-06-20" version="1">MSKMLLAGVVSLLAASTSVLAVDSVTAVDWQTDVLFLPSLNWKSTVDSPCGTPDYYTSTVNSTVIVPFIGNKVVVDGMQNNASGVLLVAVDDEEPFTQNLFSEDVRCGNLFTYELGNGTHTMSLTLRGATVTGNEGNTTQPVLHLTSITYYVPLADNSESSAGTETATSVPTISPSRKVHVDAIVGAVVGCVVGVILLGGVIFFVHRRRTKGSRHVFDPRANSTANTTEISSRSLATPGAATKLPPYARMEDDYDDKKPQLDVPSLRYTPSSDGLRARSRSPMPDRKSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYH1</accession>
    <name>A0A2R6NYH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v6974</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000692">
        <property type="protein sequence ID" value="PSR79563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYH1"/>
    <dbReference type="STRING" id="98765.A0A2R6NYH1"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR79563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12446" checksum="1225C79D37E2B4CB" modified="2018-06-20" version="1">MSTKGIIFRKGLRSWVIRGRYYMTHKYTLSLMNLIPIGSITPDGRLDPNVPNPETAFGYGRRICPGRFMAFDSMWIAAACLLAVFDFNKPVDKDGEEIVPTGDLFNTGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYS7</accession>
    <name>A0A2R6NYS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione reductase</fullName>
            <ecNumber evidence="4">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v6684</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000644">
        <property type="protein sequence ID" value="PSR80664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYS7"/>
    <dbReference type="STRING" id="98765.A0A2R6NYS7"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="299"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR80664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="47256" checksum="59F68E74C6076B58" modified="2018-06-20" version="1">MWHAADIADKIRHAKGYKFKGPGIGHPQFDWQTFKPQRDAYIRRLNGIYESNVAKEGVDYFRGFGRVVSPSEVEVTNPDGTKVVLKTDYVCVATGGRPTFPTEQQIPGASLGIDSDGFFDLEDQPKRVAVVGAGYIAVELAGVLNTLGTETHLVIRQDHFLRTFDPTIYETLGNWADHTGIKIHKKSKVVKVEGTKGQTLTVHTDKGEKIEVDTLIWAIGRHANTEGLGVEELGVKLDKKGDIVTNEWQESNVKGILAIGDVQGRALLTPVAIAAGRRLSNRLFGPPKFKNDKLSYEDIPTVVFSHPPIGTVGLTEPEARAKYGADVKIYKSSFRALYFSMVTEEEKEPSVYKLIVTGPEEKVVGIHVIGLGSDEVIQGFAVALKMGATKEDLDNTVAIHPTSGEESEYTQMAGPTLRTTFRSEIVDYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P019</accession>
    <name>A0A2R6P019_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P019"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5386" checksum="15F4896590A5149F" modified="2018-06-20" version="1">MATMSGNVQAIHNQIRKLERKKLRVKKEPPIPTIGGGSSSRTVIDLTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0D0</accession>
    <name>A0A2R6P0D0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v6111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000597">
        <property type="protein sequence ID" value="PSR82188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0D0"/>
    <dbReference type="STRING" id="98765.A0A2R6P0D0"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR82188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="26555" checksum="9A586AB536891837" modified="2018-06-20" version="1">MSSTVHVFVISPDTRSERRFDLHLTIEQLKNKLELFTGIPVQNQNILLLNNEKDTEPVTTLNEDSRPIGYYGVQDWQVLKVIDTNPATSLTGQLHDTSGVEKFELSEEAYAQRHDTVLAYKQRNKIGRFAEKDAEPEKPVPAINLPVGSRCEVETSEEGFHKRGTVRFVGPTQFGNGEGTWVGIEYDEPMGKNDGSVQGVQYFSCKPNFGVFVRPDRVQIGDFPVEEIDFDDEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0V5</accession>
    <name>A0A2R6P0V5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000573">
        <property type="protein sequence ID" value="PSR82816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0V5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6926" checksum="E839588062DB1D98" modified="2018-06-20" version="1">MTCQDHQDVSGFEVHSHAALLQDEKNAGGVWGLGGRAKLLKYLRVLGHRRMTRDFQYINSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P116</accession>
    <name>A0A2R6P116_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P116"/>
    <dbReference type="STRING" id="98765.A0A2R6P116"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="66954" checksum="3A98C6A82004667A" modified="2018-06-20" version="1">MGKRANKRLKTERPPIQETQPLGSQSATVSLLDDASKDDEERRLESVLFGTTYIPAALNENIFIVSDNENEEVGGGKELQNLLDTDLFFVDDSTIQLPGDKPEVDFDVDIAEHSDDDQDRDEASQESEESDDSEEDGSTDGSDGATAEVPVTSSSTSAKGRKVPAWTDPDDASLKVSLANNKRLRKLRDAPSEDNVGGREYERRLRRQFEKINPTPDWATKARTKLHPSQRKRRRLSVSSEEDVMDAMEEDLPDILASTGGILGRKPKSLPQGTLSIERLRDANISAPAEGAIKTLRFHPSPNVSVLLTASEDRRIRLFNIDGHTNPLVQTVHIPTLPMTTALFHPSGASVLLTGPRPFFYTYDLQSGTTQRSPRGLWGTTFSGEQMNDGSMEISAFDPSGEVLAVAGRRGYIHLVDWRSGTGQVVGSVKMNSAVKSVWWTSGAGDGRSELMSLGEDSEIYVWNVGERRCVRKWRDDGGYGCQIMGGDRAGSYVGIGSRHGIVNVYGSDATSSTGIARPKPLKSIGNLTTSITSLRFNHDSQLMAMASNTKKDQMRMVHLPSLTVFSNWPTSGTPLGHVTDIDFSTGSEYVAIGNSRGRALLYQLRDFALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1A3</accession>
    <name>A0A2R6P1A3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v5907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1A3"/>
    <dbReference type="STRING" id="98765.A0A2R6P1A3"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.810:FF:000001">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR83103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="312" mass="33830" checksum="0A9335C463166081" modified="2018-06-20" version="1">MLRLWTLRPKACVAQVRSLHASAVHSATASSEGDSPKWTPLSIRTGLIARKRGMTAMWDDFGARFPVTVLQLENCQVTANIKTVRKDGSEYHAVQLAASDRPEKNTTNQMLGHFKKAGVPAKRIVKEFSITPDAHVPVGTTLSAVHFVPGQYVDIISNSIGKGFQGGMKRWGFKGLRASHGVSVSHRSSGAIGAHQDPGRVWPGKKMSGHMGNVRRTTQNLYVARVDSALNLIFVRGCLAGVDDAHVLVRDAKKKMLSVTKVNYDKGNLDKLLPKGVVDLPFPAGTKEMAAQLPAIIVAPPSRTTSPFTPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1I8</accession>
    <name>A0A2R6P1I8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v5725</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6P1I8"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="939"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1632"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1663"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1692"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="21"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="1004"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="21">
        <location>
            <begin position="1950"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="652"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="815"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1762"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1770"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1787"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1807"/>
            <end position="1818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSR83453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2008" mass="223119" checksum="317FCAE7A1D5F740" modified="2018-06-20" version="1">MAAASSNLQSQAVQSGDLTHLVSSSTTVTVYPSDDTILSVLQARFRQDLAYTQIGHSHLVVVNPYKSLANVNDITAKEYEERSYKDTSLPLPGSSPPLPPHLYDLAARMYLIMRRRNESQSVVFRCVLCSIISKTLRLTEPWATRGITGSGKSSSFQLLVKQLLRLSTHSKKESKVAEQVKALTPLLDAFGNAKTLMNPNASRHGRYLELHFNERGRISGAKVLTYGLEKSRLNRLSHEERTYHVFYQFLAGATPDERDRYNLEDPSDYALLASSGCYRLPAGMFSDDSTAMDELRDAMKALGFKQKHTAAIFNLLVAILLLGNLHFGEGDARDVSAHVSNPLVLEHVSRLLGVSSEELGETLTNKTSYVRKELYTVMLNAAQSAAQRDSLVRDLYAILFAFVVETANHRLAPGSQDPAPTTQIILLDQSGFQTRGPGGTTSMMLGGTAPLVSAYGQNGFDEFCVNFADEVMQSYVIRNVFEDSVGLNGQLTGDGISLPQLTTMDNSACIELLRGAQLSERAHRKPGGILGAMNKASSSAKSGKGGDKRDEDLVQDLVSRFSTHGSFVANPSVPTSENVRMFGINHYAGSCSYDATDFVEKDVDLLDSAFVTLLRNSSDSFVSKLMSGPSLATERHSKDDGIIVQAQVSSRPLRQPTPIASPDGTLPTSTEEHPRLDPTKVYPVTTQINYNLSEILSCLDRTQHWTISCIRPNDSGSPNSFDKRRVKAQIRSLLLPDLVVRRKPEFVVDMEHGAFCDRYVPTMRGSEAERIRQCAQANGWTEDIDYAVGHRMIWLSYTAWKMVEDVMRSAEREAKKAITGDDDESVLPDDATEYTRDGSLHPGGGYDAGGSEDNLLLTRTGTNGTGYHTPNNNVPYAQSPLRPSNVEDTPAYSDAGTGWGSEWDKKGDRSLDAKEGGDIVVKEAPNAVEELPTSRTRRLWLWTVWGTTFWVPSFLLSSLGGMKRPDVRLAWREKLTIFTLIVILNGIIVFYIIEFGKLLCPNFDKAWNTQEVSEHTDSNDYWVTIQGRVYDVSNFIHGQHSDIQGQNSNGADSLDALAGQDLTGYFPVPLILGCSGLVQDSSIALHPANFTPVIQTAMHTSGALQSTPTSKLHNSDWYTQIFQPTINQFYKGPLVWDKGAIWSEANSADTPRNIAIWNGDVYDLTDYFNTNTLNLGDEYQFMDESVTDLFSQRMGQDISKPLEDALAALSDTSREEHLACLNNVFYMGQTDFRKSARCQVQNYILLAASAILMSSMALKFLSALQLSPKRNPEMLDKFVICQVPCYTEGEESLRRTIDSLSALNYDDKRKLMFMICDGNIIGTGNDRTTPRVVLDILGVDPKLDPEPLLFKSIGEGSKQLNYGKVYSGLYEFEGHVVPYIVVVKVGKPTERTKPGNRGKRDSQILLMQYLNRVHFDAPMTPLELEIYHQMRNVIGIDPAFYEYIFTVDADTTVTPESLNRLVASCCDDSSIIGICGETKLDNEEGSWWTMIQVYEYYISHHLSKAFESLFGSVTCLPGCFSMYRIRTADKGRPIIISNRIIEEYAEPNVDTLHKKNLLSLGEDRYLTTLMLKHFPTFRTKFTPDALAHTIAPESWRVLFSQRRRWINSTVHNLCELVFLPELFGFCCFSMRFFVFIDLLGTLILPATVVYLIYLIVFTVTTHAAIPIISIAMIAAVYGLQALIFILKREFMLVGWMVVYILSYPVYSFFLPMYSFWCMDDFSWGNTRLVIGEGNSKKVIMNDDEKFDDSMIPMKKFSEYEAEAWETGSRQSDETGYDSKPHSRARSRAPGSRAPSPHSQAGDYYRDTNLTSKNGSNPNLARPPGSNLSHYGGQPTMSQYAIPQLPFMPFAGGPGSVHGSDYGGQMPMAAQIPYQGTGSMYGMPMMPAAMPMAPRNTVMTNLNMFGGDPNGSQAGFAPPSAPGMQSQQRPMSTFSMATSVNPFSGPNMNSNPSDDDLINALRNYLSTQDLMTVTKKTAREAMQARFPKADLSSRKQFLNDAIDNILSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Q7</accession>
    <name>A0A2R6P1Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000555">
        <property type="protein sequence ID" value="PSR83663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Q7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9363" checksum="136268A12DA1AFC8" modified="2018-06-20" version="1">MCPTVSSLSFILNSAEDDSFAGPRITSNLISRFTLRLRKVSDRSCNIDFTSQWSAPKFISDDSESDEDDAWDDRLRNVLSDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P227</accession>
    <name>A0A2R6P227_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P227"/>
    <dbReference type="STRING" id="98765.A0A2R6P227"/>
    <dbReference type="OrthoDB" id="3230658at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="21776" checksum="B1B07EC1ED80FCEF" modified="2018-06-20" version="1">MEISLWERQYFESQCSSEVTLISSVFVISSATNSLLMFFRVRAVFSHSTPTVIAFGLLWAATLGGSLTVPIAFHSGPFDIAVATDGCFGTVFPAYVFSAYLISAVYDALLFLAVTYRLLFYHLYRDGQTSRLKSFFSGEGLGHVSKVLLQTGQSYYLKQDEPGGGSRYAIDGSKVDFGAIEASSHALDLKPQSSDIYHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2B7</accession>
    <name>A0A2R6P2B7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2B7"/>
    <dbReference type="OrthoDB" id="3208773at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015353359" evidence="1">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="185" mass="19467" checksum="4E1FD1EBA5C36F6A" modified="2018-06-20" version="1">MFARLASLTVLVSVFLAAKANLLPFLPFPFDLPPFIGTSGPYWIFGPQHQSKTLQQTVAFACFGGGGNCECPIDKNKDSGVLINVFPGYQCAYPNGACTWDDVTGALQNTNQGNCPSSAPCTSAGGCDCPVDLNNSTGVLINQFTGYQCAYPKGACTWDGTGALQNTQQTNCVTSAKCQQPGKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5K8</accession>
    <name>A0A2R6P5K8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5K8"/>
    <dbReference type="STRING" id="98765.A0A2R6P5K8"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="71"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR85873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="515" mass="56094" checksum="4456E2FCD5DBE3D3" modified="2018-06-20" version="1">MFARHAVRRLTLRSTQRWAHSSSVQLNSVTEQDIDHFSKILSSSSILSTLPPISTPSSELSIYNNDWMDKYHGKSTTVLRPRTTEEVSEIVKWCNERRIGIVPQGGNTGLVGGGVPTKDELILSLGNMRSVRSFDPVTGWFNLRVCVGLSISSYSGIIVADAGCVLEAMSDYLAPHHYIMPLDLGAKGSCQIGGNVSTNAGGLRLLRYGSLHGSVLGLEVVLPDGTILDQLSILRKDNTGYDLKQLFIGAEGTLGIVTGVSILTAPAPIASSNVMLALPNFENVLPLYREVKRQLSEILSAFEFIDRRAYDLAVKHGQGRALNDEDVEGAECFVLVETSGGKREHDEEKLTNLLESLLDSDNPLINTGVLSQTPAQFSSLWAIREGITEAVSKEGKAYKYDISVPLASFKDVVDTTREHLRSKGLLRDDAVKHVVGYGHVGDGKSCSIFSLSSNGLNEYIQGNLHLNVVAAAYTPEIEAALEPFVYELVGNIALMRRIKELFDPKGIMNPGKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5L2</accession>
    <name>A0A2R6P5L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5L2"/>
    <dbReference type="STRING" id="98765.A0A2R6P5L2"/>
    <dbReference type="OrthoDB" id="2564696at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR85850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="613" mass="67189" checksum="CB678F419993E50A" modified="2018-06-20" version="1">MSFTAAILDLVEILASGRNPADANVNVDPALGLIIAREILYATSFGMRFLFFWAFVSWIPYGETPPRNGLMHNGSWGRWGFLGMILQWTSLAAIFLITILQIIYRVDNALQNFGPVYELEGGLQITLSFVFILKLLLNSYLAALHSAPLNFRWMALIHYLPVIVALMLSVGMGVGNVLEFLFSETVLGRFLQAIELYILILYVMIYTFFHLRHIPSMPVPTRRINRSSSFHGLPPAGSPDSGFQIQTPYVSTPDLVSAIQRRQPYDEAEKSQRSHRPSLINTRASSISRISTWLIPGRFSRRGFPLGSPGIANDRLWNQDEAERGMSPDDDGKMQRDSFDQSLAEPKQSAKYQDPMFTAILRGSGSTGDLLSARKSTPALPSLTVPPPALYRTSGADFVMPPTPMSSDRLTDSPIYGLSGIIRPARRPPSPAEQTQPIDDPYTYFDQSARSSGISGLLRQQAELDRSIAALKLFSDITEASESQRSSVETVVLDTPKPVSASQSDFSLSIFPEPPWGRASVDTVRTLAPTQAGADINAAGADLGSLEGQDFGLLAPPVMLGASGDHSRSLSVPFSETGDVETSGRSPRTDSAGTQYEITSFIGGMSRFTYQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8M7</accession>
    <name>A0A2R6P8M7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000519">
        <property type="protein sequence ID" value="PSR87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8M7"/>
    <dbReference type="OrthoDB" id="3270380at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="323" mass="35481" checksum="EFA6694B89CF8603" modified="2018-06-20" version="1">MPRSALHPDLATAASVALHSNFDVGAFLRQSKSIQVSSAEAWDIDRVVGLTLLSPHASAIAGEAMLNKFRSRLATVTDDVDAFLHAMRLSGACLSGGRALSIVDNKATFEGVDWDFYCPFEGFDAFCIFLVERLKGTTVELGPLAQAHYVSMVGICGFRRISTERGVFDVMRSETATPLLPLPYFHSTLLVNYISADSLCVAYPLGLLSRNGVTQSRSLSEHATAGLAKYRSRGYEFHDVPWTWDPRKEGRCYEHGHCSRAVRYFGDEYCFTVKFPNRSPPSVLPILGGKLTCAWVWGGYGCGHADCLLHVPSIAHSLLIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG31</accession>
    <name>A0A2R6PG31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG31"/>
    <dbReference type="STRING" id="98765.A0A2R6PG31"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016002">
        <property type="term" value="F:sulfite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein,Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="686"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1274" mass="140320" checksum="A5F099898C66CA4E" modified="2018-06-20" version="1">MTSTSSVAAVARIAYLSSDVLVDSRPPLPTTSSFADTFRTLSHERAGSKATYSLPFGADVGSTLVQHSSVGLLSYTATSHPQLLHRLVLPLSELASTPLVLHVAVNDDLSDALVLRSTVPFCLYSRTAQQAHDNALLASRLARVEGKPVLHIFAEVEEELDEVKEEEVQSFLFAQQHSVVNGHVLPPADYAPALYRSYFDVAASTSSLVHHSVQALSQQGPTDPHTVVFSLGRAQFDFEEDGVNFVDVSLLHPLPAGRVTDLIPSSTVRVLIIEQVARWSTKWTPLYLDIVGAIQQSKRDEYPAVYSVVLENSGPVHHSDFLKLLENASGTSPSTRLHIGAAPSLSAVSETVAPHIPKHESSYLKILHQVFGERLEISNSPELVPSHGQLATTPEFALGRIRGQLESRAELVGAVQELLRDLGVTPHLHALLSKWLLVKDDPTKSRQSGEDILKALQSDEAPSTAAERVLALREYFPALSRWIVGSDAWSYDLGASGLHHAIASRLNVNILVLDATPYSSRNTADPQRRKQDVGLYAMNHGDVYVASVAVYSSYSQVLHAVMEADKFEGPSVVLAYLPYKSEDSPALEVLKETKLAVDAGYWPLYRWDPSKEVQGKEPFSLDSDSVKNDLQQFLDRQNHLSQLVRSKPELATELVSSLGENVKEARRKRAQQSYQELLTAIDAPPLLILYGSDGGKAEKVARRLANRSKMRGISTTVATMDSISLEDLAKEEYVAFITSVAGQGEFPQNARTLAKALHSAAGRSEKPLVNLKFTVFAMGDSHYWPRPEDAHYYNKAGKDLDSRLALLGGERVADLGLADDQDADGPETGYKLWEPLLWKLLGVDAVEIKEAEPEPITNEHIKVASQYLRGTIAEGLEDKSTGALAPSDTQLTKFHGIYQQDDRDIRDERQVQGVEPAYSFMIRVRMPGGVCSPEQWLMMDQIADEHGNGTFKITTRQTFQFHGVIKRHLKKAIQDINRSLLDTLAACGDVNRNVITTSIPTLSKLHQQTYEFAKGVSEHLIPRTTAYHEIWLDKKLVAGDAIKDVEPLYGEFYLPRKFKVAVAVPPNNDVDIFANDVGFIAIVDKNGDLAGFNVTAGGGMGVTHGNKKTYPRLGDVLGFCTVEQGPNIAEKIMLVQRDNGNRQEMGLDVFKAEVEKLLGYRLQPARPFVFDRNIDDYGWIKGDNGKHHFSSFIENGRVQDEPDRDFKTALREIAKIHKGAFRLTANQHLIITDVASEDVPQIAKLLATYKLDDVSQSGLRLSSSACVSFPTCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ63</accession>
    <name>A0A2R6PZ63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000421">
        <property type="protein sequence ID" value="PSR99322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ63"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ63"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="339" mass="37116" checksum="5E7803D828C782C7" modified="2018-06-20" version="1" fragment="single">MEIPPDKMHLLDDTSRVGNPIILAGILGPDLYHTFSSFQASFGKAAFQGSGEDSHVYLTQESSRQDNASPVVISFRVPTWILSNNPRDTSVFVGIQSTPETARQWASNLGLNMRLFAAKLMDTEYVHVVPLTAEGQTFLSTPSVYAGKEAPLTVSDTTTSLVIDEAGKSIKYVKIRSDISGKAKDELARVETDISVEQARQTGLNLKIGSSLIQKLETPFLVDASRSKLRVSRKSSWVDSNLDRLPTLDISKAESIQWMNPHVSLMMSDRERTLRGQGIQGSDALVISNWTGYLEVPGKNGIGADDLSTSTDNTVIGNGVLIRIIEGPRKWFKFAVDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2B9</accession>
    <name>A0A2R6Q2B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000402">
        <property type="protein sequence ID" value="PSS01018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2B9"/>
    <dbReference type="STRING" id="98765.A0A2R6Q2B9"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS01018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="833" mass="95877" checksum="39DDE3878E877887" modified="2018-06-20" version="1">MCYGENNAGHAVNYINAQLAALWQNSTHCVEQHGTHLKPEASYKYSFALAEYYYGKHRHGNQADAADMMFHARFGKPTLKFLCNHDAMLELVLEEGHYNIDYLKASELSPGNQDRNQQFHDLAVSFRVPFSWAGIRGRESKIGNEHIVKLLVFDFRKAQLISLSPGDFEAGRQALSCYLTTYLHVLQNAKHHVLFSLPDFDDDNMRIHIDFSQMATTLIDIDEIHGVSIEKINTYLSSSWLKSAMLAGHQDGNPIDRPAISLAEYRSTWVLNDSNIHFHIKLGAPRVKALCDEEVIMYFTVDEALFYETEDFSVHPHRSFAEWEFAILVDVTHEKEDNGNVTRCKLDLQRYDETDEVSTLCLTRLIDFLSVEYLVILENAQYHVIYHYDVRWPKFSGLVDEGHAYDMDGETDDGEWSRDVGEENGGRVGTSRTVLWREITEKSDMCGFDQIMAISQSAVNSHFYSMWMAAQGNKSSDDAAIARWAHQEFFSATFKPITLRLLTNGRAIVWVHLQDGFLKTLRNWTPWDESEKYDFQEWRLAFEVDLKMCEHSELQGVTSAWQTKFESSFAFKDHGTERVLNHIYLDLQKAEFIHEFSRFEGLFTAQHKRPIDKVQAIVTYLRNYYFPQLVSAGYHVLHTIPVWKASPSISLPCHALTSVVFHVYSKSTITRQTWSDLSRSAEPVIVVLGMSGGRPLPALQLQFSTEWVARANKGVSYGTLSLSRRVFLEERLLDLLSRVNAVTTVLPSFSGIEENKWNLELTTWANHPMRADRPCRFFRMDQGDLPGILKYKWEHRDVWNYEHEGSKYIMNGTYSVSCESQLQPKEPIALTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5G3</accession>
    <name>A0A2R6Q5G3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000397">
        <property type="protein sequence ID" value="PSS02374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5G3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS02374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="248" mass="27783" checksum="03E2EC2B737A2635" modified="2018-06-20" version="1" fragment="single">MSMHRLVSVTAHTNPFHLPHFATGIEKFRLSDVEWLGAIVPNLRRSQRTPFQPLSVTHISILFQNAVCPRSFVIPTVRDVRALECFNVHPGSCASLRGLICANASTLESLYFAARPSSIYGPIWEGTGLSSCVTLTRLDISVPFFMGVTESASQLRQRSSTFLQLLKQAPRTLTSLTLLLDFRWMELSEYYRTLSSVDWTALAEQVGQQPGLRSLEVVAATEGPWNSLYVPQEFEHQVRRIFAAANTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB47</accession>
    <name>A0A2R6QB47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000374">
        <property type="protein sequence ID" value="PSS05362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB47"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="262" mass="29899" checksum="D4BE4DF9D635332C" modified="2018-06-20" version="1">MKLKHETLQSYINGFGEFYQNITKELYSVKNMIAQGGSITGTSDVEARKQEDFPKIQYWNKDNWKQERKSFIGNTNPQSTARWNPLGFLEHDNGTALTSKEESHIQRIARGVFLMMDQSMKIAPPMTWDHGAAIEHCQAFCDELESDYPEQWIKSQSPTKVSPLVVDVDMHVSADKPQPHVNLVKKRSVPDPLTGMHRHTKKAKPSGKPDLLIHDPMNVCGRKWATRHPNGTEADWEAYWSKLPESEKKKTAEKAKANDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBI6</accession>
    <name>A0A2R6QBI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBI6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10864" checksum="10220A67BE1C0E54" modified="2018-06-20" version="1">MEKVINTGLRREEIKEIRYIGQGMRGGVKRDRKQRVFRSRSDSMHNDSHRRCIIVTPCLRSVLVLDVLHLLPYPGLVRIHHPGWRLLLLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBR5</accession>
    <name>A0A2R6QBR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000366">
        <property type="protein sequence ID" value="PSS05555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBR5"/>
    <dbReference type="STRING" id="98765.A0A2R6QBR5"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30673" checksum="968937E65F59617B" modified="2018-06-20" version="1">MSMQTWQYDPSGVVEARVREEIKSWDLFDFSATQYQGPIQTSVCVATTMFGHTHIETQVHIALFSLLAGCVDDLEIDPVALEQFVERLHAGSGQLHPVLDLLAQKLRRMPDYYPPYTATAIFAGTIQFINATLFDKLSPLRPVSLPFIRYKRARNSLGEVYGLFAWDKANFPDVSVHIQILPDILSFYKEELAGEENNVIHDRVSVTGKTVPEVLSDLLDEAVSSVERARVILQGEKEKETWERFIAGYVAFHFLSPRYRLKELTGSEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIM8</accession>
    <name>A0A2R6QIM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIM8"/>
    <dbReference type="STRING" id="98765.A0A2R6QIM8"/>
    <dbReference type="OrthoDB" id="3270840at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS08852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="458" mass="50132" checksum="207F19127B94E202" modified="2018-06-20" version="1">MPQIYRRHSEYLPRPPLEPRRRSTIAPRPQVTDADESIVLSDLVRTGEASRLRRRGAMRLDHGAPRPILNPPVLPVSPTSPPSRPIVLVPTRPSTPPSFTADPIDNEDYSYNGLNWREWQSDFPAASGATTMIAEEGNRDSEHDDPDEGYVLTCGGAIPDERDIRPFEPSILPIPPSKTASSSTARPRTTNRTNGCGAVVHMRAFPQRPRSVWVGKEEATEVVVGMDAAYFDRNVVAKMQRSACGCIREGVGCSVCGNTLGTRYLPCQAASDGIFSRNNPSFRPSRPTCPSGRSYWQPRSAPRNRPTPGSSFSSSTRSSAGAFYVYTFFADHVTSSPLCNDMPATQDEPSIRPDMIPPPLNSRPTSPWYGYTRTASPRPMSPYFAPAFQTSELPSVPPPLSLSIPPSNPLVTSNARPERIDGELGIQLDADGVLVESEDLMEPGSPDKAPNEPLWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R400</accession>
    <name>A0A2R6R400_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R400"/>
    <dbReference type="STRING" id="98765.A0A2R6R400"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS19951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="672" mass="75599" checksum="7B283678BA712738" modified="2018-06-20" version="1">MQFQSSIVATVTSYLPPSKSAQVRPCLPRLPVPDLHSTLQQYIASLQPFLLSVEQGDNSEENYKELLALRAKWAEEFGTRIGMVCQERLKCMCYSRAHVVTRILTVDVALDRTSPHNWLDDNIWLQKGYHQRRVPLMIDSNWWAAFTNDPNVPRDVLLGIADNQGGIDGTGVTGWQVRRAAWLAWRLLDFKGKMDRCIRMSEAILEADLFAYRQELHPSTTETGLWFRSSMSRMFNISRLPHTSCDTFSSLPSPDFPTARTLLICVRDWFYTIEVLDAEMNLIDVKDLEKRLMGVVFDVASRLKSSEKAVPVGVLSSDGRDKWSENLAYLLTLAPSNKDTLTAINHSFFAVSLDHYTYGLPSPTSASQLPLTLPRPSEWNSLEEVDAHLHNLRSSHPSQPAHNRWFDKSFTLIVESNTRAGANGEHSALDALVPSMVAEYGLTQGIMENVFGGSVGFNNHCDELGSEIGWKRQDWLVDNRIRQECLEAEERAKEAAEDSDHSVLCFDAYGANWIKNDACLPPDAYVQMAMQLAWYRTQGIFTATYETTLTRMFHHGRTETIRTLSSDSRAWVLAMMDSSSVQTQHTLLQKAVKTHSNLSRAAATGRGIDRHLLGLRCMLRPEDGEAPSLFKDELFSRSQTWKLSTSALGAGTQFRGTGFGAVERDGYGINCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7C6</accession>
    <name>A0A2R6R7C6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000272">
        <property type="protein sequence ID" value="PSS22642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7C6"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="2">
        <location>
            <begin position="70"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS22642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="331" mass="38329" checksum="AA6A6855935A69AB" modified="2018-06-20" version="1">MAEGNPPGLETNSQAAAVQIHLEKLTETERKLFNEKWKNFGVAQILNEDQKLDDSDEHSKRRIRRWVMSFAEFVQHIDVYLKIVDKVVGAFPDAVAIVWGALTFLIEAAKNVANYFKKITDTFERISMEFSKWKDYEDMICRGDEAVRAAIIQAYGTILECLTCVFRTYKLADGKTTRGGTIICWFICVPIHVIKSGTLGIIWKVLNPRENKRFDYLAKQFHDHSENVQKEVNHAIKIHDQFRKFYTNPVIVSHSRWFHLPEEFETRLGDCGESNNEYQQVLRGKPSIQPGNWLLELPEFKEWKDMSNEKRVLWCHGKRGSLVYSGIGALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI97</accession>
    <name>A0A2R6RI97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI97"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF11">
        <property type="entry name" value="MAX-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="357"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS29735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="47566" checksum="0BE0E04AB974311D" modified="2018-06-20" version="1">MSGSESARAEYPSGQLVTSTDSEKVAPGSPNFLQNGRYVSITNERGSHQLLEEWKVRTDDEDQLGGKMKCAGCGKDLGRELARDDGLWRDLPGEPRDAISEGDTRQVAHQRTQPEHKKHLKLFHRFAYRFELSGIPFRYPPATPSALSVILAPPPCPIPPVILNHLVPMETPAHMEVHVLDHSKDFMDTSSTYFDHTLSGLEYLQYPSDSFEMGLQTSSSPRIGGFNSLNLNNGGMSSYTYGPSTSSYSTGTPARPYTPTGSIYPGALSGLADGELSSDSVGSNRSRRGSGAISPPPGSLAAVPRSHRFNPLATAVTRTSPRQAKKRSKGSDDFDSDNDDDFNPSTSMASNDVRREEIRRQRIESEQRRRDELRDGYRRLKDALPVSNQKSSKVSLLDRATTHIRYLEVTQQQLQTRLAQAEAETARLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIH2</accession>
    <name>A0A2R6RIH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000252">
        <property type="protein sequence ID" value="PSS29820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIH2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11297" checksum="3E01F2ECDAE896A7" modified="2018-06-20" version="1">MEHPPCSTEPPMNNIDDIRPPPSQVMRSDSAQSQADSSQRRMDLNISEPQNLNKDPNINVVHQSNHRAKTKHERQAAKGKKEVIRANLVGTLDMPGDFMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIN4</accession>
    <name>A0A2R6RIN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000247">
        <property type="protein sequence ID" value="PSS29875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIN4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6610" checksum="4AE9D3C3D5407AA9" modified="2018-06-20" version="1">MGAYHRSVVAMVPNLHVISVIGQRTLPNLDLTGRVFVMEKLGLDVMSMAGEQDDPELDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLM4</accession>
    <name>A0A2R6RLM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLM4"/>
    <dbReference type="STRING" id="98765.A0A2R6RLM4"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS30930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="363" mass="41224" checksum="89B3E4122D7945E7" modified="2018-06-20" version="1">MLPTARVVEGGCSFIQLARCDFESQNRAKIEQRVAKEKGIVVIFLESVCDDPAVIAANVALKVSSGDPDYKDMSREDAKRDFLRRIKQYESVYETITEPHLSYLRIINVGNQVTLCHIHGYLQSRIAFYLMNLHLKPRSIFFSRHGESQFNVDGLIGGDSSLSSRGATYAEALPDLIKDNIGDAPLTVWTSTLQRTIQTARYLAYTKLTWKSLDELDAGVCDGMTYEEIEQAYPEDFANRDEDKFNYRYRGGESYRDVVVRLEPVIMELERQDNILIIGHQAILRCLYAYFHNLPHADLPYIKIPLHTVIKLTPKAYGCDEERYTLPIGAVDTHRPKPGAVQPQVPVSSTGREYYADTGDRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLN9</accession>
    <name>A0A2R6RLN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000231">
        <property type="protein sequence ID" value="PSS30938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLN9"/>
    <dbReference type="STRING" id="98765.A0A2R6RLN9"/>
    <dbReference type="OrthoDB" id="3271139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="193"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS30938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="747" mass="84432" checksum="4BAE33DB997A4308" modified="2018-06-20" version="1">MAKRKPNRQAKSNLPRAASPAASKRTLTASCRSGSLQEKRQAAIDDAQGYSRLVPLQTFFRSQMPPVDLRLVKDVIKSLRSGQNPVIVGKRWADFQVDPAKSNHEVEEVIFRPLVDIMKAIAKAATVASSGGGPRCTYESNPNAVPESESRDNLTRPDGWIIRMGGKSSGKEAHWMDMAATGEFKKKENETTTADDHTNFVRFVLGMLFSNETELGWDPTLTRRENGQFDMEWHSKSGEKQVYRTLKLISDYGADALIGPAGRVWIAQRVVSGELIGDPAILKDIWIEDDRKREGDIIQEICDSLPADDRPESSKPFLTVLCHGDVLVPSADNTTHPDNHTLHLHGRFLSETCPIYRFTPAAVRKAPFCPLKTAVGTHHTEAMLHERYREPERIPISPKTHYRIVFKEVCRPIHDELSLPSVFKGLSQMPYALQLMHSAGWAHRNINTGSILLDCDGNVKLGDLEYAKEMNDENSHPSLMLNSDFVALEVQKRAYLFLDGKLLKPRKGNANHRIRVRYLASVRGEPPTPRSRDSDFDFDPCEAILVFKHIPLHDHESLWWVIAYFVFRRRLVGDNRLTDCVNKQERTASLIFKERLLFLTSHKALTNELSCLPSSIFALGAMLENMRAALGEAYKEASFYPGSWKEALDAIEKFMSTIDEKLSSKIPVLHGFMLQPLTLSDEEPEANKVNIDEEKPDRKRKRETPQDATACPECRRNQRAAKRVRLECNAPSSRTRSQTAGQRRQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPJ3</accession>
    <name>A0A2R6RPJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000215">
        <property type="protein sequence ID" value="PSS31909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPJ3"/>
    <dbReference type="STRING" id="98765.A0A2R6RPJ3"/>
    <dbReference type="OrthoDB" id="2793484at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015337098" evidence="1">
        <location>
            <begin position="21"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="2">
        <location>
            <begin position="73"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="3">
        <location>
            <begin position="237"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS31909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="649" mass="69173" checksum="7DF1A218E0A05E19" modified="2018-06-20" version="1">MRQVLLAAVLSGVFCAISSATSLAGRTLTPVRRAHTLNNRELAYRSIAPKRDIQLDYALSVHHPPAASVSFTAHNGLPILLLEDLDYLFESVLCSENVNNHIPGTMDLRFASADAFEEALDTWTDSGTFIVVTSHPSCNIANERGAWTVMATDGNFSQRSIRLTAVPTSMGNVGRTCHVKYDHSGVEFWDAREVLGLSRRAEQDDTQVFPFEYQSTFGARLPLFPPPNASLVPASVQNALKNVDIQIACLDCGLTSNLSVGVDFEIDLGDTNCTPSPTQNCFALNRAAVNFTVEDIVLSAELELFIGAEYTLSTQFDVLKIPVGPSFKFGTVIEIGAFFGLGVALDLDIPASLNITYGSQLHALTGAFASLDLVDGNGNFDPAVNAGGWDNVSLSQIPFRVNSGELDVISTLALQPFVEVDFTILEVGATARITLDLPEVDVNASLHTTTVNRECNPIGDNDFESFKDAFTVGAGLELDIMASFVVDMGEFIGSDIPNTWNDTFFHHEFPLLPSKGANDTGCFVLNDDPTSTTGTVASGSTSVTGLPASSGTLLAAASAVPSWNIPKIQSYLSASGQLPSNVNYGQMAQATTVPSDIKAAVAKIKTSSSGSKSTPTNKSKSNAAGKTSSAFTCWQSLLLLCLVGSWSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPU7</accession>
    <name>A0A2R6RPU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000202">
        <property type="protein sequence ID" value="PSS32053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPU7"/>
    <dbReference type="STRING" id="98765.A0A2R6RPU7"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS32053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="345" mass="39548" checksum="6A056BD0CBD1BD9A" modified="2018-06-20" version="1">MQQQHHQIASTSLYSPPTKIRIPDLVSHCDFPLKNNRHRKQATVECKQWLFRGGNLSQKKRDAFHGLKAGLLTAMCYPQAAYPQLRVCCDFMNWLFHLDNISDDMNDRGTSKTGVDIMNVLWCPDTHVPTTRVGKMTRDFWKRIIPTATLGMQQRFRETLDFFFQAITQQAKDREAGVVPDLESYITIRRDTSSCKPCWALIEYANNLDIPDEVMESDIIRNLGEAANDLVTWSNDIFSYNVEQSKGDTHNMIVVVMKQEGLDLQSAVDFVGELCQGSIDRFVHDRANLPSWGPEIDRQVAIYVDGLADWIVGSLHWSFESERYFGKTGLEIKKNRTVNLLPVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ92</accession>
    <name>A0A2R6RQ92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000188">
        <property type="protein sequence ID" value="PSS32193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ92"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="676" mass="73085" checksum="BE8CE651C5EDAC93" modified="2018-06-20" version="1">MATRQSLPRAKANTRPAEKAGLLPTKRRTSEQVRADNEEKERRKAADLAAKAAAKNAKVSRIAELEEQMAVDDADEQLVRHTAPPPEPPRSRPRPCLCTGPQLTRTFAISDLNGTYEDGCQPECTGVIVTNVHKVLAPSGASVTAGDGGYISGSEADNASVEDAVIRSPPKKKQKSAIREANKGLGAAVTKGVTRDKPAQNSPVFIKTWASDVFTQAIRTPFNSRAGTARSSSAPSFTSSSAILASIPVYDSENDSGSNYNGFGNDEDEIIERIAALALPSKAGVRVTSNGIVGLVQPKAEEAEAQPAVRKSRPTTGIRVEPISELDEVQTVPLSTKTTTTRTTANTKARTAKATATVATNTVATSTNVVATSTNATNAQLPAGVFGRWRSQFVPTYMIFVGGQRDPWNINDPTAEAAIKEAFTVVYPNVPYPQDSVAQQGIFGVLNQRIYEYRGGFGSTALMALHDDLGALPQLNCTDLQQAHLKQMLEKKAFLYEKFDMEMDRVTPYWGGLLRSPFIIQTFAHHFTFMEGAKNVPGFAELTPKGALALSAAAMERAFTLWAEGMIGFNKRGVPIVLPAHNARTGKESKIQNAFAEQNWGDAIRLYARSVENLKSGSFAKIVEQAKAFANQTHLASKRHVPMVINCDLDDEMDDRGCFQDLSSDEGKSLNVIDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVM2</accession>
    <name>A0A2R6RVM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000159">
        <property type="protein sequence ID" value="PSS34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVM2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10147" checksum="228AF9A359FE5604" modified="2018-06-20" version="1" fragment="single">GWRRAREECKRQLMGKSISLGLSEETRHMYEESLGQGMQVDDQLDDDATMQFDDNAGPAGGDVPRAGESSDNLEGEEKADEFVSAVHDALAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3A5</accession>
    <name>A0A2R6S3A5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3A5"/>
    <dbReference type="STRING" id="98765.A0A2R6S3A5"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS36743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="9853" checksum="DB3D5FED0B872871" modified="2018-06-20" version="1">MSESKFNKAVEIIQALPKEGPIKPSQDDQLFFYSYFKQATIGDVNTTRPGMLDFVGKAKWDAWNKVKGTSKEDARQKYVDKLLEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3T2</accession>
    <name>A0A2R6S3T2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3T2"/>
    <dbReference type="STRING" id="98765.A0A2R6S3T2"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS36950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="399" mass="44845" checksum="ACA9FA0488E52836" modified="2018-06-20" version="1">MGLPRRRSVDIGGLALALSDEGLGHGWGGWEETEKGETRYAEVLIDVRAHTETIVNLEPLQLSPYIIVEEDTRTRLIGSLGSWHFEPHKLPEEEVLACTYILFESLFRIEGMQEDAGVSLTQIATFLQHLRQNYRRGNSYHNFQHALDVFQATYFFLYTAGIVPPVSILSYIDGRLWKPDKKVARNSHLACLVNEDLLALYIAAVGHDVGHPGLTNAFLRNAKTPLAEVYDDKSILEQMHHSLMLQIMKSNGLGVLLDRPISGQRFRKLLFLIVIATDMGIHPEFMTRFQEMIDGNPVDSFQERVLVCQAIIKCADISNPARPYLVAQHWAAALESEWTSQLLLEQHLNLPTSVRPAKDEISEASGQVFFLTAFARPLFDLTAMGLPGKRSVARLVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S413</accession>
    <name>A0A2R6S413_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS37002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S413"/>
    <dbReference type="OrthoDB" id="2798053at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="638" mass="71815" checksum="1355BEEC25E3E7A4" modified="2018-06-20" version="1">MNEHEAGIPDFTQATAKELIAALRRDHTTADHIQTIWKVLLNRWDKRQTHDLVVALIESGCNAQIFLAELLRAIYTKFLGEDVSVVGTYRTRQIVPNTVETADTFSGRWQRMIACGWYDPHKKRTKEESKFVATWGYSFEPPSAVSWRPASIRGMISSRAPPADELGRILSEAKALGQDIDYVLSRAIPLHAEGLIGLGKNTEARAYIFSYISSLYNSASGPQSSPEISRLLKVSRNLPSDMRTEFVRQMYPILNSLSLSDTWHTLPEKSDISSNAAIDTVGLPCFWYFLIHLATTGDAGRPEKEPDEDVIINLLFPLWTQLNRTVRVPPALDVSELNQSCFIAAIMWMMVGGLSKNQNSYDWIRGLPFFWESLSCARLPEVDNFLENLGNAILWQAWKDVRRGFMRLVDAAMKKSSPSNYKKCPEGFCSMIIQLFIADSTVIPDDSKPATLILLVRQFAMCGDFARGFQNSLVKLDSNTAKTVLSAIIKLLGPYPTEEERADIQSLQETYATYAYEDPADLPPHLVDRFISSITELARHDTTLAEALIKAGIVSLVSVIRDERYEYPPAEDVVPPHVRKIFRERMCEDAFNALQERTYLAAQKRLLYENPVRLPAPSAPASTMSRHRGRPSWMATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4S4</accession>
    <name>A0A2R6S4S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000068">
        <property type="protein sequence ID" value="PSS37281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4S4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5724" checksum="0557BCC41A3F3B3F" modified="2018-06-20" version="1">MPPVDPWALSQLERMVGGPVDPNLVEQYEIDIQGDSDEDTDEHEVSLNDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S562</accession>
    <name>A0A2R6S562_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S562"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS37359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="651" mass="72906" checksum="F5619CE8D317FD29" modified="2018-06-20" version="1">MSSSTLPTEETLHEEKKHYVIKPLVDLVDDPNLEQDAEGLEDDSPYPEVRAAVANTDDPDMPCATFRAWFVGLVWAVIIPGLDQFFFFRYPSVTITGIVAQLISFPIMRVWARFVPAVKIFGVSLNPGPFSIKEHVIITIMANVGSGSAYATDIIAVQRVFYNQSPSFGYSWMLVMSTQLIGFSIGGIARRFLVQPPSMIWPSNLVTCTLFNTLHSQQYAGIGSRGGISRERFFLYVFIGSFCWYFLPGYLFGALSYFNWVCWIVPENVVINQLFGTASGLGMSVATLDWAQITFIGSPLATPWWAEANVAAAIVIFFWIITPILYYTNTWYSKYMPISSTGSFDNTGNAYDVTRILTPEGTFDPDKYKAYSTLFLSTTFALSYGLSFASVTDFLLAIPEQITVIMFIFGVVCIEVWHTEMPVWAFILALFISFFYILPIGMIQAITNQQVGLNVITELIIGYALPGRPIAMMMFKTWGYITMAQALLFTSDFKLGHYMKVPPRPMFWCQVIATAVAGTVQLGVQSWVFSNIPDICTKHQKDGFSCPNTTVFGTASIIWGVIGPARLFSGGQLFNGLMWCFLIGAAIPVLSYLVQKRYPSSFLKYVNWPVIFTGTGLIPPATPSNYVTWISNIDYHHILLPSVPQERIYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5P9</accession>
    <name>A0A2R6S5P9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5P9"/>
    <dbReference type="STRING" id="98765.A0A2R6S5P9"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="152" mass="16878" checksum="BF55CD5C3F6D2012" modified="2018-06-20" version="1">MTNKSDGSHIRVAGAVAGVGSVAYLTNNVSSFDTVKTRMQCSPPGTYRGAIHCLSQIVRNEVCQPPPMLEPINIAQKLHTDTSQYSRYLRFTREQHLRQLGGPLSTLSCSDLSIITDCISSVINGLNKSLDLSRLRNDSHFLGTEWQVWERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5Q0</accession>
    <name>A0A2R6S5Q0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TFIID subunit TAF5 NTD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5Q0"/>
    <dbReference type="STRING" id="98765.A0A2R6S5Q0"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="135"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="514"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="646"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="688"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="825"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS37617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="955" mass="103149" checksum="A4FE1D8DD805ACB9" modified="2018-06-20" version="1">MSAATPAPSTPDASGAAASPTATAQDSGGLSSTDKLVLDYLRTRGHAAAEKVFRESLEGASPTDRPAPSSSTISSDDLATKIAVYAQKPTRPGENMLKDSSAALSELAAMGNPSNIQNLIASIGPVGAEEILSLDPTDKQEGFRELEAWVDGSLDMYRPEFRPILFPIFCHFYLDLIQHGFKEAALRFFSEFSASLQSHHSATLHHLSTLLLPSHVQNDELAQRFRNEKYQIRMSRSGFGLLVGWLTEGVGGEATGVGEGFSGERGKRGRAAVMRVVNNHLKFDVTTSSTTTFSANSWEEATGLLSSLIPQTNGASLVADPHAFNQSKGELKLGPAPISSELQAETERVLREQAMVDRDPGAQYDAHFARVATPAGITSPTIADLPPHPPTFKAVDVRREVEKVRDARKRIRLDPQVLFNVNLNAPQGTAARSRVLPSICAYTLHDTGEGVPCVTFSQDTSLLAAGFSESYIRLWSLKGEKLKGYRSDFQASSVKDAASLRKQREKGGSTTRKLIGHSGPVYGVDFDPVSGSAAPPRFLLSASADATARLWSLDTMTNVVAYRGHQHPIWDVQWSPMGVYFATASRDKTARLWSTDRTSTLRVYAGHLSDVDCVRFHPNSLYLATGSSDWSARLWDVQRGSSVRVFIGHQGIISTMAFSPDGRYLATASEDLSINLWDLGSGKRVKKMTGHTASIYSLAFSAESSLLVSGGADWTVRCWDVKGSGELASKARENGMVNGFGEENGSNGGTAGDHEESIETTDLLATFPTKRTPIVDVQFTPRNLCLVAGSRFERDASLWLWRDASSIKERVTCGGHLLSSACSLVRSSSSPPNSSLGPPSTMDSATDMNMDFQEGSASVLPSPPHLLPQKTEGQSQGMLLNSTHDPLVATSIPGNAPVSDGRFREISVKVHVRRPDKDNWAYLGRGMVCREVFGRGSRIGVSFATFNCLSPTQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S670</accession>
    <name>A0A2R6S670_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase</fullName>
            <ecNumber evidence="1">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000031">
        <property type="protein sequence ID" value="PSS37787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S670"/>
    <dbReference type="STRING" id="98765.A0A2R6S670"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="3">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="3">
        <location>
            <begin position="84"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="374" mass="41716" checksum="3473D80FC7F65484" modified="2018-06-20" version="1">MNDTAWATRHRPNTSAARDLDHLPGPRQVSFAGLRFRVDADLQYVSWMGWGMYLGFDRDMGLSLWDLRFLGGRIIYEVCSVRSTISALTVGSLHDHVINFKVDLDVAGTDNSLLYTHTVQEEVIHPWLDDDWGQTVIQQRIVHEYIQDENKALLKFPENHRGGYAIVNQAEPNRWGVPRGYAIRPGYSPIYNTVVGSKRLLHNANWARYNLAISRRKDTEPSSSSTWNLNLPGAPTVDFHKFFNGENITQQDLVAWINVGMHHLPQAEDVPNTRANIATSSFFLTPLNYFDSDVSIDSTNAILINASTEGAPSNIDEYGVAAVQCMPEMVPPYHNIKLKAFALDYGEPAPVPVPAATGGGLGRLGELRDVQDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6D3</accession>
    <name>A0A2R6S6D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v370</name>
        <name evidence="1" type="ORF">PHLCEN_2v5827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000031">
        <property type="protein sequence ID" value="PSS37769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6D3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5290" checksum="AAF78C3176A7D2BE" modified="2018-06-20" version="1">MLEAAKIWAESGPNSYQGFGGNMAILRGMLETIGGLTVEEGSFKRLNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDY4</accession>
    <name>A0A2R6NDY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001347">
        <property type="protein sequence ID" value="PSR70587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDY4"/>
    <dbReference type="STRING" id="98765.A0A2R6NDY4"/>
    <dbReference type="OrthoDB" id="3261081at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="174" mass="19338" checksum="E06663EA2EBAE819" modified="2018-06-20" version="1">MSFSSPPPSPLLSRSSPNSPHSPLRGIPLRLPDVANVIIKLRRARNQAQVKDYPIESTSGEPQTHPNFSGENVVSARKVPLVEERRFLCRDGVDVKKLLRMMRITLLEEAQGIGANVLVDEQWSCVIHAPRRDGVFKVDIRYTASAARSAQRDPQQPVTLDRARCVPGLMTVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEE1</accession>
    <name>A0A2R6NEE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEE1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="224" mass="25085" checksum="7674D8724F6E1FB3" modified="2018-06-20" version="1">MALDNTVGHTLLKGLKPLIGIENAQQNLWLFAHAACTCCGEGQHKCSLASFGPSKFKTRSNKVSRKLSENPTACLDGSLREPHRTIPATNSTMIPSPAPRVRRIRSLLHMKEAQNFQGIGKPDELFSSEKSHKVDDEVSISATLKMKAELYDQEIDSLREQVEGLQERLVEARGIVDNAEQYLEDILSRNIKLERELRTLKCERVEIQTAAEVCDRDCPTERTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEI0</accession>
    <name>A0A2R6NEI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001338">
        <property type="protein sequence ID" value="PSR70648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEI0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="336" mass="37411" checksum="D6DE069068A0E3DD" modified="2018-06-20" version="1">MDRTTYNQVVLDVSTEIRSKTNEDSEYKMDAGAAHGISQGAQFTLYVSDVGVATLIAEKPAISSTILKMKEVIGPPLSNEDGYVRYLWGGNEEDLRLCVTISGSKSPTCNVPGAPNVSGHISHSPPSPQMTGEELRSKIAELKNVRRGINLVDSHLAELIVEIKEHEVVFYLCNHELESKPDSKPNSTLAVSFLGATICAISKFKLSNIWSFFGMSSESAFHHHDWSTNILPYTVPPNIAVVYPVIDAAAHYFYHLRRAPVEHHLNTKVIVEFFEVEETDEMDETGLRTLRTKGKNMIIDGDVGNFWRRPGYSETHLEAQMSTDSRDEIAKETKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEM1</accession>
    <name>A0A2R6NEM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEM1"/>
    <dbReference type="STRING" id="98765.A0A2R6NEM1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="55524" checksum="0813C9F6C12B1B6C" modified="2018-06-20" version="1">MLAFNEQTRIATEWLADFSSALQSANAEAFAAMFLPDGWFRDVLTFTWDNRTLEGKDKIVAYLSKRLSPAEVSQVKLCEDCYFRPMYISGPEQDVETGFTFETPIAHGKGYARLVRNEHGEWRALLASMMLVDIKGHEELPGRENFEDIAANRSWGEMEAERKGLIESDPHVIIIGSGQTGLQVAARFKQMNIPTLVLERNTRVGDNWRHRYDSLALHTVREHHQLLYQPHPSTWPIFTPRDKVASMLESYAVNQDLVVWTSSAIVGRPVYDSETRTWDVAIDHAGAQVILHPAHIVLATGTSGDPYIPKLEDKGRFTGTSIHATQYKAPQPFSGQDVVVVGAGNTAIDICQDLATCGAKSVTMVQRSSTCVVSRDSVARHMLHTWSPKVPVEVGDFKFASLPLGYMKKTAIQRQQQSWDQEKELHDKLEKGGMKVHLGPEGQGPNLLVFERGGGLDKGAADLIASGKIKIKQGCEPKAFTERGILLADGSALRADAVIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEY3</accession>
    <name>A0A2R6NEY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001302">
        <property type="protein sequence ID" value="PSR70923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEY3"/>
    <dbReference type="STRING" id="98765.A0A2R6NEY3"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="329" mass="36157" checksum="074581CE3396C6DE" modified="2018-06-20" version="1">MFWGTLADRWGRRPMFLACMLVLSLACIGLALVPVNAYWLLMLLRCLQAAGSASTIALGAGVIADIATRSERGGFFGLYSLGPMVGPCLGPVIGGLLADNLGWRAIFWFLCIGSGVCFVAMLLFLPETLRSLVGDGSFMPHPFYRPLLPIIGRSHAGAGDQEKPEKKPFVNPLRLFLSPAVSLLLLFNAVLYAVFYGVTASISTLFVDTYPFLNETDIGLCFLAIGGGMLAGSWLSGKALDKEYQKVKKNLELKCREDPECKIKPEEVTKDENFPIEYARFRTMPIYFSLYIAACIAYGWCLDRKVNLAGPLILQVLSEFLLLIIILMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF57</accession>
    <name>A0A2R6NF57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001297">
        <property type="protein sequence ID" value="PSR71003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF57"/>
    <dbReference type="STRING" id="98765.A0A2R6NF57"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="5">
        <location>
            <begin position="321"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="489"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="570" mass="64307" checksum="031DA3FE74F05C4A" modified="2018-06-20" version="1">MEILNSLSKNDFILQKTYLIILLDTQTQLTNRTLNAPLLRYVDSVRTHGHRAAQIDPLDLLEREEVAALDPSRYGLTDPSACYDINGIIWTSPVGTDSGPTKWELKDITRHLREIYVGRIAYEYMHSPSKTERLWFSHLLESQAKPAESASTGIAGRDPPWKKFMWLLLRKSEIFDQFLQTKFPNLKRYGLEGGESMIPALHALFEAAAAAKLDHIVLAMPHRGRLNLLVSLLDYVPRALFHKIKGGSEIPEELLEMGASGDVVSHLWKTRAKQFSLLKSLVSGGLKEEECFPGDKVMCVQLHGDASFTGQGVVMEGLGLKVARAVEIAFKYRNYFRKDIIIDLIVHRRWGHNELDEPAYTQPLMYEKIRSRKSIPSLYEEHLIANGTMRPEEVDVILADYRQWLAGELAAADSYSTPLSSAPMLKDQWAGLVWPASEDAKRNPDTGVEESTLVEVGKASVSVPDDFTLHPRLLRHVKPRIQNLESGKNLDWATAEALAFGSLMVEGYDVRISGQDVGRGTFSQRHAMLVDQNSERVIVPLNDSLKSTGRLELANSKIVYLFYFTWSRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGA7</accession>
    <name>A0A2R6NGA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGA7"/>
    <dbReference type="STRING" id="98765.A0A2R6NGA7"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="579" mass="64037" checksum="F232CE0328C9B068" modified="2018-06-20" version="1">MDDMDMMAAMGIAGFGKQAKNKQLDPNRFDKNKRAEVSLPHPPANDVDDDQPSIPVTSSGFNGEEPEYDPDEMGPPPLKSLPKELEEPEFDLSEDESDFPEFPTTHELILKDHTKVVSALALDPSGARILSGSHDYDCKLWDFGGMDWRCKPFKTWEPAGTYYIHDLKYSNDGQQFLAISGTSQAKIYDRDGEEKATYVKGDPYIRDMKNTSGHVAELTSCAWHPKDPETFITSSMDSTIRIWDIENKRKQKTVIVVKSKERGARTKVTACGYSPDGSIIGGACFDGALHMWQTKSNFVRPNMTIEGAHSKGTETGSLVFSVDGRTVLTRGGDDTVKLWDLRAFKKPLAAHSNLATLYPTTNAIFSPDDKYIITGAGATAKGEKGRLVFLSKDGLESVKELEVETTPVKVLWHSKINQIVTGLANGQICVLYSPNTSINGAKLILNKGPPRKATIEDMSDALAAPTIITPHALPMFRDGEDARGTKRKRDKDRLDPRKSKRPELPVTGPGKGGRVGASATQHVVQNLVRDTTRDEDPREALLRHAANADQDPVWTSAWRTNQPKPVFAEVEKEEKEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGW4</accession>
    <name>A0A2R6NGW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGW4"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="15677" checksum="62474CA9707A0E8C" modified="2018-06-20" version="1">MFSAFKRTISALKLLNAALTSSYPPSKPSAPPLSFDLEVVENQPPTSDQLRTILSYLPSGSASPETFVSSHPTVESRPTSTDAVARLASQNPHALKWPIVVDWTGGKAAVGDVEGVQSILEELRKRRDGESMDDEEHKPKGWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHB4</accession>
    <name>A0A2R6NHB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001255">
        <property type="protein sequence ID" value="PSR71681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHB4"/>
    <dbReference type="STRING" id="98765.A0A2R6NHB4"/>
    <dbReference type="OrthoDB" id="3052667at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="20542" checksum="2F0F0A2915E5DE91" modified="2018-06-20" version="1">MAGLRPGPSVSLSGAILRPPSLSPSGSGGFVVHQQNRTSEDSTAAAPSPPPQAIIPSQSRPTRPLPTVTEAVIPDLPKNRKGEPSIAWKTAVKHWIEGDSSIGLSCALKSWPSQWFSREMSRVTGAKYKQRELIGREYERLGSDDGIFILEYPEAAVGIKALLAAINKRREERGELKPRRSKNGPPGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHL4</accession>
    <name>A0A2R6NHL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001240">
        <property type="protein sequence ID" value="PSR71860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHL4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="5580" checksum="B8C31299ABD9F5E6" modified="2018-06-20" version="1">MGADLGHGPAEDVSVDDETEDAEVGFQDESASAERSPEECSDSDTLWTTSVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHN7</accession>
    <name>A0A2R6NHN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHN7"/>
    <dbReference type="OrthoDB" id="3062869at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="16089" checksum="3A335E13030D1253" modified="2018-06-20" version="1" fragment="single">HTLRPSKTPQTLEGFGPLGRVRVLKGKGKGPPHTAGFHVYCYPVWASLAQDYLSIMATFVLSERAFLQGSIIISKRRNCLKNNIIEALQCLKCAIRHDLLLQASSPSSVTEETISKEELTEASTMSDEEESGSVWNLILKDDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI94</accession>
    <name>A0A2R6NI94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001214">
        <property type="protein sequence ID" value="PSR72104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI94"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6653" checksum="1977415167574790" modified="2018-06-20" version="1">MTPNQNEVKASIKAEAARAKKAKVKERKHAHEANTELQVKNKADGKRSAGDAPARKRVAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIN2</accession>
    <name>A0A2R6NIN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v12343</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIN2"/>
    <dbReference type="STRING" id="98765.A0A2R6NIN2"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR71842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="473" mass="54365" checksum="6BCCE1D365B457D2" modified="2018-06-20" version="1">MAALRPPSPIQRSDTPSGTPLGFFSAPFERFVRDDLSDFASGFTLLDTMETYFDSRLDLIQRSLTKHSDRLKVKADKAFQEVFKKEVLQKIRSPSGEVLADNLEREMQKFKLRVSQRMTSLAASWQSAKIVRTREKITFFFGVMSLLLTALMFGLYPQYIHIAYTIQAGYLLPMRAYYYKKRSWHYFLFDLCYYCTILNFVYIWILPSNPALFVACYCLSHGSLASAVITWRNSLVFHDSDKVTSLFIHIYAPLTFTVIRHFYPNAEQRFPALSELPHLKPFRALLLTGIIYLIWQLLYWKFVLIDRRKKIESGQRTTSFSFLLNDKRGVIGRSLSAFPLQLREAAFMLGQLLYSIITELPAVFLLYDSPFWSAMFLLLIFSVSVWNGGGFYIEVFGRKFERELEALRKELAEATSRSERSSPTFGPQSDDDLSTVAASPTLSIKAISPGISTVELPLEQIPPAQPDETRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ51</accession>
    <name>A0A2R6NJ51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ51"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ51"/>
    <dbReference type="OrthoDB" id="3192267at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="12832" checksum="FF4A2426B50956A2" modified="2018-06-20" version="1">MSSSPDSQSGPPCYVLVSHCPLAVDSSAPAPSYTLFSHPTIEYHYADDLPHALLPQSPDEHVVVLDYDPALGASPTAHCLSTSLAVVAVKVAEAPGAGLIEEDGPKNSKMYVVQTTTKPDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJK0</accession>
    <name>A0A2R6NJK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001169">
        <property type="protein sequence ID" value="PSR72491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJK0"/>
    <dbReference type="STRING" id="98765.A0A2R6NJK0"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="41"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="27381" checksum="2DCD364223C0DB3C" modified="2018-06-20" version="1">MFAVVRSALRTSSRNAFLRSSILPTLPVRFLATTTTWLDVTQEIKIDHDNVRDLYERYTRASSLEDKKVIANTLIREMSIHGDAEEISVYNDYKAVGLRDTAQHNKDEHAEIKKLVWKAEHAFTSSDNYDKIMTETVDAFLAHAIEEETEQHPKLLAALTPEQNDVNRPVLSLWALILILLRTQKIARTFLKARRDVPLRPHPLAPQTGGVLQKAMGMHGKIQDKVCAVVLFECLISKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJU3</accession>
    <name>A0A2R6NJU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001160">
        <property type="protein sequence ID" value="PSR72508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJU3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6624" checksum="FE29B2692095C569" modified="2018-06-20" version="1">MLNDQQQSQDESGYGKPKAQKKRRFRACDMCRRRKGRIHHLADPVTKILTTPTHSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKU6</accession>
    <name>A0A2R6NKU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR72999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKU6"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="9"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="783" mass="87371" checksum="604BD8BFC6C3D65B" modified="2018-06-20" version="1">MSTEEKPKAGLFSAVLTAFIVPAFGLLQQDNTQVSADILARISAKLDSLQITPSFINSTASHAPSASSFTVSASARWINILWFLSLLFSLSSALFGIFAKQWIREYLQWNQTTASPWENILVRQLRSEAWVKWKVPAGIAAIPALLEIAVVLFVIGLVIFLWTLDRVVALVISVAAGILLIVVFVVTTLPAFFQHCPYKSPTGWACAFVYDVVVWGIRIDLRFGRAHPYFSSWRHRDMYTSRRVSEEGSQDELLPPARYLFAPEKSIKNIIQLRPLLQALAWVCEGSEDTRLSSEVVRCLDTLPNRGSDSAGWEIQSYGTLYTFWKLCSRRRGMAYSLPIGPLLDSFFIYANCQLIHGYTVEGLHVKRFGIYISYRFPSFGIHAAVQSLGRSEIWLISNLILVDLEVCVISKPWNITVGDELTAYRWTKRIAMHLVLLGFLGIRLRVLDGDARATDEICGRLVKMCNRVPMSADALSIHGMILYFACRMGTVCIRARTKELYLVSRLSDTQEDQEGWSVENIDSAFNLTIQIFDQNPNYADPAARHRFTIMANWVLSKAFFLLKQKSAMLLEKMTEAARISLINGYLNCGCYHDLPWISASSSNLFVSSYVNRPLVYPLFDILDQFKFVDTSSSNPLKDSDLLDKSGKVVAIITGEGVKEDYKRLKAELRSRLGPNHRGGPTDNSASLPRAGPSRGDGEGEVVVDAAGRHVHSHTAPVIYRPRRGTGQLEVGTISGGSVATISPAGHIMSDTLTAAGSQVHRSNADSDKQRRTHHKRHLNSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLA9</accession>
    <name>A0A2R6NLA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 12 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001105">
        <property type="protein sequence ID" value="PSR73116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLA9"/>
    <dbReference type="STRING" id="98765.A0A2R6NLA9"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015307085" description="Glycoside hydrolase family 12 protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="26108" checksum="F94AF00C21E1B622" modified="2018-06-20" version="1">MLSKSSLLVLVPFFTSLLGSPTPVDLVTRASIDTSSHCGQWDSVSAGSYSMLLDLWGESGATSGSQCANLVSMSGSTIAWKTTWTWTGGTGVKSFANIQLNSGINQQLSAISSMPSTWDWSQSTSGTIVADVAYDLFTSNTAGGSNVNEIMIWLANINAGPISATYSSSGQPVPVASNLSIAGHTWNLYSGSNGANNVFSFLPTSGTITSFSGDLKAFLTYLTQNEGVSTSQFLVTAQAGTEATSGSATLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLI6</accession>
    <name>A0A2R6NLI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLI6"/>
    <dbReference type="STRING" id="98765.A0A2R6NLI6"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="102"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="287" mass="32749" checksum="71B135BFCC2F4818" modified="2018-06-20" version="1">MSAEAASASAMPEGVTDPNYKPLPGRLGNLSVPQQHALDKFRKELQDEEIYVPERMNDGMLLRFLRARKFDVPKAKEMLKSAEQWRKDFGVDEIVKNFDFKEKEEVDKYYPQYYHKIDKEGRPIYVERLGKLDFKALYAVTTQERQLQRLVYEYEKFLTERLPACSQAVGHPVETSCTILDLANVSLTNFYRVKDYVMAASSIGQDRYPETMGKFYIINSPWAFSAVWSVVKPWLDEVTVAKIDILGSGYKDKLLAQIPAESLPKEFGGKCECPGGCSLSDAGPWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLU3</accession>
    <name>A0A2R6NLU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001095">
        <property type="protein sequence ID" value="PSR73230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLU3"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="564" mass="60105" checksum="429F44D3BC77C3EA" modified="2018-06-20" version="1">MPNQGSVPPVSPFAAGEITETIRAARKSTQFWLSFLAIITSIFLSALDLTAVATALPTITADLDGGDDFTWIGSAYSLSSTAFLPLSGALADIFGRKPIMMGSILLFAIGSALAGAAQNMNMLIAARTIQGLGGGGIISLTEILTSDLVPLAERGLYQGMLALTWSFAAGIGPPIGGSIAEKASWRWLFYINLPLTGLALILVFFFLHVRTPVGSTKEKLALVDWVGNSIVISGSTLATIGLTFGGIRFPWDSAQVLAPLTIGLALLAAFIFYESRRSGQATIPWEVLGNRTTVGGYLGTFFHGVTSISIIYYLPVFFQACLGASPIRSGVDMLATALIIAPFALLAGIMVQIMRKYRAVNYLGWIITVVGFGLLSLLKANDAVGKWVGYQIIASVGTGMIFAVTMFPVLAPLPVERTASALAFWAFVRAFAQTWGITISSTILQNELKKNLPLAFVSRFPQGIEIAYAAIPIINGLEEPLRGEVKEAFASSMSVIWKTMIGIAGIGLLTVLLLKEIPMKAFTDETYGLSQRKEQNDVEVGGELGLEAAAASEKDEKSTHSIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM28</accession>
    <name>A0A2R6NM28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM28"/>
    <dbReference type="STRING" id="98765.A0A2R6NM28"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="245"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="245"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="631" mass="68127" checksum="3352E48F409EA38E" modified="2018-06-20" version="1">MAAALSYAQDTLAKPLTTLNDSHDSHDPLPDKISAYYSLVFPNFTYYLQTLNVTIGRRCIPTSTASSSDNPQVDVDLGPLKSVSRLHAKIEYDEDEERFVLAVVGRNGAWVDGVWSGSGSQVPLGDRSQIQIASRTFHFILPPPPAPEDSPSPSSLSSVEHRPRSPSVDITSLDVTSMSPPSSIPPCSPPVTAVLTSPPPKKTPPLPEPQLPNSNSITRFKSTKKRKKSDADAFPRMKPEDLPPKPQFTYAQLCYRAIKGLDGRGSLQEICQWIQDTYEWYKYSDKDWESSVRHNLSSNRAFKKVERGPEEKGKGALWSLDPQYEHTFEEQDCRKQIGDGKASGKKGKSAPLEPALRRSVKGDFKGALLPPPLTSAPLVMKNVQNNGANAGVPPTTNVSVKLEPSPTPVPTPFSSIPLSTMTPSPSPSLSSANTVVATSTPGASTSSVPQAPSSLPVIPPSVRLPIVIGPAPASSEASNPEPKPIVLHQNTLILNPTIFAHLAPQQLRELEALGAQKALDILQTYIVRFYKEKLRAESGRGRGRGGRGRRPRGGGVQTPGRPQAANDGLFTTAPLPTRTPKPQLQVNTESTPPMASLQPPPESAPSPVIVVDDDDEDAHVSKRPRLEGEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMM2</accession>
    <name>A0A2R6NMM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nucleoporin NDC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v10641</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001070">
        <property type="protein sequence ID" value="PSR73529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMM2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMM2"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR73529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="75139" checksum="A22700F269D4B402" modified="2018-06-20" version="1">MSSLSKSASGLSTPIRALPSNLASRAAPSVPPASQTYEPLVKEVLRHRLLRVFLSSALFSWALVSSCSGWSQGGVTTLGFFNTLLVPILPSTLAFAASTWVLGVVPVVVLRKSYLTATPTAAASPSKVFSAATDKRNTLRSLSIFMISSLFMTCIHAATTYVYEATSAHQPHLTLFVKSKKHPYYLNGRLLFLVTSQLSLAALYLLRNLMIDRFLVRWKDSLGKPEVRSFMLARVITGALSTVFLAVMSTAAHVLLFGLSRSILLPLLYKLPFLHRILRPVSAHFLRGSWSITLFTKNLALIYRSFTLAFTTAINWEFAESVFDSQVAEPVTVAHATADAALTLVSGITSKDSYYKYFAYTELQHLASDDSAPGSTLRTAMFSDQKYSPSMWATLARETLLALGNDYQLLLRRGAPPTTVPTPTAVPAKLGVPAQVQSAPLVRTQVLKPAHPSPLRSALDTFAADGPISTVISSTAEAGASQIPELFRSVMPAHSPVAAKVESAVETVKKGEEEIKNIVSVRASEWKARLYGELTRYSPHAVVEIGSRVANWWTRERVNKVVEASLPNRKMDALAIDEDRYGVVQCDIPRILEALLSFLTSIEDYQSELRTRYPAPSQEELDNLSPKELAEKEKIAYDVVKAGDVLSEVADRKLCQFESSHPEPIRYSSIKRRHREGGQDFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMS9</accession>
    <name>A0A2R6NMS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMS9"/>
    <dbReference type="STRING" id="98765.A0A2R6NMS9"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR73694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="501" mass="55968" checksum="7A5C5F21AF8F30D2" modified="2018-06-20" version="1">MAGPTAADVRSILSLPSPSTPGLSQPRKPPGTTERARKPEGISRELYSLIGTSAPTLAAQLAKPRLKQKPNLGGGGRVKWEWRSFKNGARADSLRLSHWMKAGTDSEAEYQFAKYNVQSNVYVYSQDEYVRLLSDKEWTKEETDYLFELAREYDGRFYVVADRYEYGNGPPRTIEDIKDRYYSVCRKLVRNRPWAGDEASKAQLISSFQFDKDRELTRKKYVASLENRTPSQIAEEEALFIELKRLEQHERRFKKDREELLRTLAGIECGLPDVQAEEETFVGTQTETKKTKKKGVANNEPETPTSATASGTNVVLAQPVPRKQTAKSAAHDALHCIHRTEIPQTSTTTTKAAHQPVYLRSYKLPTPKSSAAPKIAQVMGELGVSHTRLVMPTRENCAQLESLLEAAAALVETKKQVDRIEHETMVTQERLGNRTSEGAENDMDVDEEGGDAEAVGEDGRGQSVVSTRSVRSNRPRKKSARSMSISSVDTTATGGLKRKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNA0</accession>
    <name>A0A2R6NNA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nab2 type CCCH zinc finger 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNA0"/>
    <dbReference type="STRING" id="98765.A0A2R6NNA0"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049017">
        <property type="entry name" value="Nab2_Znf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21803">
        <property type="entry name" value="Nab2-zf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nab2 type CCCH zinc finger 4" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="528" mass="54979" checksum="C1915B0DE928A913" modified="2018-06-20" version="1">MAFGLTIGTERATALQNSIQDELTRLGYSAEAVIGSDFGKSRGGHSRRRNEVLTPYVDSAFVDWLFAEVSKGVPEAEVPVAAAPELVSVSPAVVHDDPPHLQSDTSRRGPGGNRTGNLYQHAITQAIPNPSPTAQKRSASARSPSPTGHINKSRRTDLLPTGPRAMQRDGNPLGGSRSLLERMGPSRNGHPHPPYAKDDIQARIDNITGSPAPDMGMMMGPGGFPMNGVPGMDMNAMAMANPLMLQDMLMNQMALMSQMAGAIGMMNSGMNVPGPYPMQQQGMGGEMGMNGGTNGMDGAGGRGRGRGRGGSRGMGRGRGGHTPATGDAQGATQPTPTLIQAPSVVAPTPMAASSPFPNMASPQITPSNSQGRQAFVPPDRPLSPTLCKFGLKCTNAVCRWSHPSPVATPESGVVLSNEPCENGKNCKDKDCVKAHGRVLPSTFHRGLAPTGGMVSVQTPEAGSMGAPSPHRSVTFNKSTPPPSAAELEKRMKEVEEKRILAKAAVAEAQAAAAGKKDDASRPTSAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNM4</accession>
    <name>A0A2R6NNM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNM4"/>
    <dbReference type="STRING" id="98765.A0A2R6NNM4"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="221"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="714"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="954" mass="104502" checksum="F8443B0F3D7EFBD5" modified="2018-06-20" version="1">MSSSFFRPKFDMQGSNQNALTTLPDLVEFNALYNPSRLFCVQYTHHIYQVPRRITYKELHHAVLRCSTSLEKNGLKQPPTRINQKARPVALLMASDVTWFIYFISLLRLGVPVLSMSARLAPYATAHLLKETDAQAVLTSSQLDPLVEEATSLLPEKLLVIHALPYGSFADGDLPATSWGTASRSTTHDDKNVVILHSSGTTGMDPHTAFAENPPLKQSLGLPKPIYHSHAYLLGYASCHRLSPEDVAGAMNLSTLPLYHGYGLLAPCLSLSIGLPFALPACTTIPTGSSTMSILSSCRATSLMTVPSILEEIYTEASSKSIDALRALRFVAVGGAPMKYSVAEPLANAGVPILNHWGVTEIGAIAPIHIPEAEYDWRYLRLRDDINLRIEPVDSGDDAQYYRLIGRAPGSRVDFVVQDLLTVNPERPCEVRVVGRADELIVLATGEKVRPSLLEQQVSEDPLVKVALAFGDGRFQLGLIVEAAGRARVNVSDPKSVTAYLDRIWPSVVQGNDMMDHHARVTREMIIVTTQAGQPLLRTPKGSIARNPNMELFKRDIDVIYRRADVTDAKALPIGNPSRLREVIRKAVQECLTIPRAIADEDDFFERGMDSLQAASLRRCLAAAVASTSKSSGNTSNCLPLDFVYTHPSITRLQKGLIAYLTSNKRQGTSPSDRIHQLRSVAEEYVRKVADLRPAPSTGDPRKDQSIGRKVVLLTGSTGSLGSAMLAELVMSADVSKVYALNRRGTRSLRSRQEEGLRRLGVRLGDDWQKIVLLEGDLASDRFGLDKETYLGLTDVSHVIHNAWPMCFNRSLSSFRPHLEGSRNIIQLALDSRACTPVNVLFSSSISTVGRYPLTTGQGGPVKETALDNPQAVDHFGYAEAKWVCEKMFEKAGRAFPSKILPHSIRIGQLVGSDATGAWNSYEHIPMIVKSCQAIGCLPIIDGVSTSTANSKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPR4</accession>
    <name>A0A2R6NPR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000984">
        <property type="protein sequence ID" value="PSR74475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPR4"/>
    <dbReference type="OrthoDB" id="2803005at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="866" mass="97866" checksum="ABEDEE0364B18801" modified="2018-06-20" version="1">MKKSVTFAISRSSEDWILVSPSGFTPCSAWCGVSPGPLKYPGLLNPTTTLIIPHMQDTLTRLWLHWQSTEPAKLPKQLQLSVAHQLYIPAPHLQITDLEMDALKLVLEYVDLVGKYHVDVSVNHLKGDVIAHIQFVADTNWQLQFPEPDFSISSAASNGLSSRRRRNALSLLMRVRGPYDGGIDYSLERLIKPAMDLLFDTPRYRLLSRSDGSSQYNTLDQDLPLVIACSSEELTDSERASMAEAARPTLLAMIWHFDAEDGTRPLPKNTFVYGIHWGRRLLNIFVYFPFRKSSGTWEFCDALIAQQWLTFEDDYDNIGPINSRDDLFLDQWRLTVACFTVRTHVQHWESVPLNTPAVPLSEIDVNLASKTLAEKQFELMAAPTIVPRTDHPDRESIDPKSERRGQKFPSSLQAVVSRMKAHWRGRALYVPSEWVLPAELTIITREATWERSSLYIRNLSKLYLHAIRDDLLPLSKTDLEDNHVSSTYVGPDYIHSIHQPRSQFNWWLLHIDDRKANTEPYRFKVYDFLSMDAASWDNVNLFVSHVFAGFSAYAVRWCVMSHSLGINILNPWLTNRKPSIRYPVPPAVITPSYVVDFALMIQTIPPTTEPMIARFQKMPLTVSSPGILVGVRPLDMSGDGSTVGSDELESLAHIMRPHLQVMAMHAQHPLPLLKDASDYVLEVPILFCTYLKRGFLHIVAFHFETKSTVNEPGSSSAYLVDSLPLTLACDTQGDLMDRMRILVALFTLQRHIVRLCSGSSERSWPQDLLDEEQQWIIEETGFATPNPSFGVPSDRGEEASWWYESAGSMDTENAGPCEDELEASEMKVKKWLGELIEDSDSCEPEPAVVKHEVGTTTVAAATGKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQH8</accession>
    <name>A0A2R6NQH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQH8"/>
    <dbReference type="STRING" id="98765.A0A2R6NQH8"/>
    <dbReference type="OrthoDB" id="2526979at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="34863" checksum="A5FB8CEB76775FAC" modified="2018-06-20" version="1">MSYSATSTCALPCSRSRSPHGASDAVPKSFSVDLILPNVVGASVATNTQSRETSSSKGTVRFPLHPSAQPEHLPKPRAVQSLRLAHGRSRSTTTSTTSTSSIFAGSRRARAASTSESSSYAGVAYKYTMTLPRGIVPVVEPISSLVTETEETIGSFSPTSCPRRRLHSILEANTPSWSPTRRKQQRLRVITSPELEVGFTSNEGATSSSLPSPPLSPIPSICRTPSSYSESDYFSTAPSSAGPTTPVHSTASSPLIQHKTLRPILEALEDASKFHVRAACAACGTKGSNYPYCPRCGEMWCSRECRLKSTGGKRHVCAKKSKKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQP4</accession>
    <name>A0A2R6NQP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQP4"/>
    <dbReference type="STRING" id="98765.A0A2R6NQP4"/>
    <dbReference type="OrthoDB" id="2148418at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1274" mass="134801" checksum="D9A9E1E177394281" modified="2018-06-20" version="1">MSSDPETFSSTLEAASTPPPRRARGPVRRSNRLSGAAPAKAAASSQGDETEQDSDASPDAGPSASDQSRSDTPMIPQDTLEEPSFALAAKVLHASDNPSPPPSPPPTPPVDSAEEEPVLIDFAPPFLESVVDHVSESDNIAGSVSHDFPLLLPTQPVLSSATEEDLISFDSLSSHTPTPMPLMAVLPPTAPSTPSRSQAAAHTVDDLLTLSPVPLIPTTTSHRLPSPFHDGILFSQTASRDPTPSGDEEEQVAAALSSGAYDLLSSPELCASNASNEEPLVILDQPNKAHSSELLHTPVRRSTRERRSVSPFVIPSSITKASRIADSSSHLSPVRQSLDPSPAQTRRKQMKLKQNSRGEIVSDSAADMLGTSCHSPIVVDSSPLVTPVVLPASEEHQTTPLPHEKSTALGKGKGRADQETHRLGSLSPTSTNALMQLLPPARAPSSDDSISIDAKDPTSTDLMTVQPSTLSAPDPLQPDVDPSSPCHDPNVYDRPNTPPPRPVDPGRTPARRVPIMEAISQGSVSPQKVSTFHAQPLGTPVFRARAPDDPLRSPAKRIPVSGVLSAFPSPQKHVPIFRFSSPLKSSQSQDSVPQSAHKAQRSSSTEPSLSQPGASKIGLFTRPDPAGSSVVAESKAGLAFASTSSRFPPTIPEGDESSSTGLPKSPAKPLPASSLRQPTARVESRIPRVGSKPYARPTAAATARTRLLISAPAKKPSSSIPTPAVARPLRIVPKVPSKPKPPVEVETSSTDNTLDVAIAGPGPRTIVNRSIASQPPVVTAENVTVTSLKRKREAEGSRTSPTGTRPVVLIRKVVSAPSNPKPSPLPIRIASPVKAGRNPATVQGRVQMRKAVGTKKSRSPATTTTPPAPSEAELEEPKDHPARTGEGAVVVADVATESNETAGSALPDSGAAVAVKAQSMPLVPSVSESTSSAEEAHAADAPQQSAEPLNPPPPPSIEVEPESSAAPLSSGLRRTTRSSRKSAEAATDVFGAVTCTTTTTTAAATTRRSSKTRGGRPTLLGPPDTSAFSSMSILALKSLTAANTERNQKQVAELQTEVVVKEGKRPDSPTTKVRTVLEKQKEEKSLEREKRAARRAQRLSQDAAGDASDDDGDGGNEEEEEEEEEEESVMSLDDEVHSNLTGHRRGPGDDEDYTTPERPERPLKRGRFETEELEKEEKNVKWDRGLSTTVWLDDSPPQPRITKDAAARKGCLAPSSKSLRLDTMGNVLNIESPLTLVVENITVKKFVYEGDAEEQEIPPEAPKMTRSKKKAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQR2</accession>
    <name>A0A2R6NQR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQR2"/>
    <dbReference type="STRING" id="98765.A0A2R6NQR2"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24441" checksum="0C4B40E96098D232" modified="2018-06-20" version="1">MSHTVDENWVRSDLYHNSFLVRPDPALEHAIEASDEAGLDKIAVSPAQGKLLNLLARSINAKRILEVGTLGGYSTIWLARALTEGGHLVTAELEQKHADVARKNFEFAGLSSKIDIKVGPAADTLRNMQPEQPFDFVFIDADKPNNLPYYLEAKRMIRKGGAIIVDNVVRSGRVADPSEDNVYVNGVRKLLAHLKEDKDVEATTIATVGEKGFDGFTYILVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQV2</accession>
    <name>A0A2R6NQV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR75006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQV2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6306" checksum="197330B4A6F60CAE" modified="2018-06-20" version="1">MSLLAGSLVTFQRGRLHVVFVGPVCNGYGRVKSILPVEVPVAAGQLGERATFPDPVRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR85</accession>
    <name>A0A2R6NR85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000921">
        <property type="protein sequence ID" value="PSR75180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR85"/>
    <dbReference type="STRING" id="98765.A0A2R6NR85"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="330" mass="36543" checksum="0AFEBEADD605A602" modified="2018-06-20" version="1">MASLQHTANKRSASRFAQHCNLLGPDDSMGEGDTELVLDILPSGLASSAFGNLRKEVQWNTMMHRGKSSVVKSLDWWQSKGKSPRMEGKGVLIGTAVVVSHLASAYFSFPIYRHPADESPQLHSFSPTVSLIRQRVENALGHPVNHVLIQHYRNGADYISEHSDKTIDVVRGSKIVNVSLGAQRVMTLRTKKDVQAEAPSTQRSYQRIPLPHNSMFVLGLETNAKWLHAIRTDKRPEKTKSDAERFENGERISLTFRNIGTFLSADQARIYGQGAKGKTKEGARPVVRGGSDAEKLIVAFGNENHQGDFDWDENYGEGSDVLHFSPAINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRF2</accession>
    <name>A0A2R6NRF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRF2"/>
    <dbReference type="OrthoDB" id="2317741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="14016" checksum="75126698CE4C0351" modified="2018-06-20" version="1">MMFMTAIAALLGVASQVANAAPVHETRDVWDPRILYPHAGTVWYSGQRHNVTWETSDAPKQITGANGGFILLRSGEYETPVVLAHDITLLDGRVEVTVPDVITGNFSLVLFGDSGNWGDDFLINGVITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS54</accession>
    <name>A0A2R6NS54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS54"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="9403" checksum="B54D290A2C1F8080" modified="2018-06-20" version="1">MRPLRTCHGGRKNVSYNTSQHDRLIIYAPYAPSKRPHALGHHVASEEHIDPPPTVKTLVQVALITAHDSLETWKKSASGVPDEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT23</accession>
    <name>A0A2R6NT23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT23"/>
    <dbReference type="STRING" id="98765.A0A2R6NT23"/>
    <dbReference type="OrthoDB" id="3260441at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="631" mass="72656" checksum="7CB21E966EBB90B5" modified="2018-06-20" version="1">MKKPKISGNSRIHHVIPLDDRPEEPDTKGKRRARNAGKLAQLMDVPLDIFFEIISKLKPLDLLQLSRVSKQFRETFMSKSSRHLWIAARKNVYDMPNPPECLPEPKYASVVFERNCFACGVGRSPKTDYALCVRFCGACWKSNVAKGKTLLRQHKGMDSTILTMLPCVQLGAGYLSSGCHADSTKNSDWMTFYVPEFEAVVTRYRSLSRDISAMDAYKKERQESATVMLQHGKAVHEWEERMRREQYDEGVRAQNKRKASIEQKLLEMGYQISDFPKWSYDWSRLLGQPRELTPRIWKQIQPKLLLIIACEKQRKLAHALRTRMDMRKAEVKQQYQLYLKDVLDDKLLLPNIWELVTLPEVKALMSEEEATIEVTRERFMGVVSQAVVTFNLEERARLVKMLQEPALRIPDYNPYEGREKDTTTPMDAEGDVEKLNHATSIFSCSRCDPASPTSIFYSSGIMEHSRKFHPDAPRRPVVGVLENVVDTASVVLKMLGLSSHTPHTEVPKKVVCLCGRPDFQQPAEFLELVVHIKEEVRWYKQTMSNRRNPSETTDQEITIHNDHDLSIEKPFVKLLLDDETFLPPDPITHNLDLPNCIECRFCVQLITPHSRSSISLVHQTATDFVHHVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTB9</accession>
    <name>A0A2R6NTB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v8540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000850">
        <property type="protein sequence ID" value="PSR76308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTB9"/>
    <dbReference type="STRING" id="98765.A0A2R6NTB9"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR76308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="463" mass="49958" checksum="74F8EAB4264025AF" modified="2018-06-20" version="1">MLTQDHPNESAATGIARAAKEAFTVSQLIPSSERVNALHEIRKELENAKDKILEANKRDLEAAQKEVDAGQMSPSLLKRLDISKPDKWNSMVEGVTQVADLMDPTGIVSYASEIDENLELYRVSCPIGVLLVIFEARPEVVVNIAALAIKSGNAAILKGGKESNQTAQLLSKAIQTALSKTSLPSSYIQTIQTRAEVAALLELDQYIDLVIPRGSNSLVKSIQSSTRIPVMGHADGLCAVYLDESADVKKAVRVVLDSKTDYPAACNSAETLIIHTEILHTVWPEVAKALVEADVQLLCDSATLSALSHETPSPPKFGTHLCPSAPADYTTEHLSLKLSVIAVPSLDAAIHHINTHSSHHTDCIVTEDEKAAAKFCRGVDSAGTFVNASTRFADGFRYGFGTEVGISTGRIHARGPVGLEGLVIYKYMLRSKGETGHIVGEFGSGEGMRKYRHHPITAHKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTI9</accession>
    <name>A0A2R6NTI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000850">
        <property type="protein sequence ID" value="PSR76317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTI9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="262" mass="30640" checksum="353B68114111D92F" modified="2018-06-20" version="1">MSLRSFYSRLTNSRTLRLQKHYFPSVQDLMRLVGTLRSLEDLHLSYISWGRQPVNQPAIRISFLLACLNAEQCQEQWIMVWMLTASYPRALPTARIRHYPRPALEEHQQVCVAGIVRAFCQKDNKVKFEWTYDSSGQSWHLTVENVEANHEPGSVSLRRLNFRLVRRGPDENASIVQVDTMTFDLAPSPSSLYPFSEEAIKAFLSYRWDEVDSLLSPLQWRSIVIRYNDCFQSIDDPEIIHKISKSSVWKARRRTYEFYSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTL5</accession>
    <name>A0A2R6NTL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000846">
        <property type="protein sequence ID" value="PSR76427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTL5"/>
    <dbReference type="OrthoDB" id="3205170at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7453" checksum="13BE9144E2A6473D" modified="2018-06-20" version="1">MSGETDTFDLQDRDYRYDVHFRCWNSATNMKACVDPTNGNIKRDTPRVRALLRDCGWPVGSAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUB8</accession>
    <name>A0A2R6NUB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-L-arabinofuranosidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000835">
        <property type="protein sequence ID" value="PSR76770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUB8"/>
    <dbReference type="STRING" id="98765.A0A2R6NUB8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14585" checksum="683EBAF382816FD4" modified="2018-06-20" version="1">MRGGISVRVSLNSPAFSGETLPEWISTIKGQPSILDASAVLHDSSRKSLRVAVVNRSETESYEVPIRVAFAEIAVKEVEVHELWHSDVNAQNGWGRENEVQVRTRRESWHGKWTFREHSFTLLVFELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUP8</accession>
    <name>A0A2R6NUP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3 8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v8070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 8"/>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUP8"/>
    <dbReference type="STRING" id="98765.A0A2R6NUP8"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="11">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR77081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="378" mass="42688" checksum="C34D33EDD73D70AA" modified="2018-06-20" version="1">MRKLGLRGLEIAELYDIEPWAVDHLQPRALIFCYPCADDDIKLQDSHNEDSCLPDPDAEGIWFAHQLCNDACASQALLNIVLNLSRIRVGAELERFKRDTEKMDPVMRGLAVTNCQFIRQAHNSLARPADLRGSSHAVATSTLEYAKSQKKTRRNSDSSPPKKRRKQNFGRVKKPQPESAEEDVENYHFIAYVPIDGKVWELDGLRLSGPLEVGEITSDSEGGSGRTDWMSVVRPALRRRMQSLQSNESDHVRYNLLAVVEDRYEKASDALEMLKRKRNRLESRLNEELPEVWTSQVDPSLLASRVEAFATSSQGPSSLGPTYNPEFGSRKLEMEMDILDMPARKLGEAWETCVRNAMTAKVAVEDELSNSIRTQVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUU3</accession>
    <name>A0A2R6NUU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000810">
        <property type="protein sequence ID" value="PSR77165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUU3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5486" checksum="FE91D7D37B6811A5" modified="2018-06-20" version="1">MAHAQTSCANFKKLASMKASTGIGKGEWSRGQPPDSRLKQRQRKASKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUZ1</accession>
    <name>A0A2R6NUZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v7980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000803">
        <property type="protein sequence ID" value="PSR77287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUZ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NUZ1"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR77287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="272" mass="29899" checksum="0D5837EBCF817EC4" modified="2018-06-20" version="1">MSGRLISQGLLSARLSLRSPKTFVSARTLGTLPPRVIWRPKAPIAPRVADLSTAAEIEAELAAERASNSSVAPSVAPSVAPTPTESIDPIPALNGLETGTDWSRSYQGLSQQPFAKEISDVLLAPVDPLDVEIKPDGLIYLPEIKFRRALNRAFGPGGWGLAPRSETNVGPKVVSREYALVCLGRLVAIARGEQEYFDPSGIPTATEACKSNALMRCCKDLGVASELWDPRFIREFKAKYAVEVFAEHLPTKKKKKLWRRKDQPKFDYPYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV82</accession>
    <name>A0A2R6NV82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000799">
        <property type="protein sequence ID" value="PSR77328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV82"/>
    <dbReference type="OrthoDB" id="3271139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30261" checksum="92E33FDECE6F8457" modified="2018-06-20" version="1" fragment="single">LNSDFVAVEVRKQAYLFLNGEPLKSAGQDPTYRAKTRYLASRLTPVSRDSDFDSDPYETILVFQHSPLHDHESLWWVIAYFTFRRRLVSDRRSATKVTKQELAASSIFNDRLARFTSSGALVKRLSCFHSSIRPLGTMLERMRQTLVAGYRKASFHPGSWDDTLSAVEAVLSTFEIDKKLSIKASIWDGCAIQPLTRSDQENRADIDKEQPFRKRKRQTSQDTPAYPGGKGTRGSAKRARLECETPLDAPSMQTRSQTTGRSRRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW10</accession>
    <name>A0A2R6NW10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000765">
        <property type="protein sequence ID" value="PSR77972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW10"/>
    <dbReference type="STRING" id="98765.A0A2R6NW10"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1275" mass="140449" checksum="2304FF88394091D9" modified="2018-06-20" version="1">MKSFSSDADQAAVTAKSRRLPPVANRLLKLTVGLCIGAILAQLRNYYSTKSQHCTLHPLVVGPPAKEWKDDVWPIRQQTPWDISTDYPYPRKLEYDVTEGTWLRLDVHPKSGDIVFDILGDIYCLPRDAYSDSANPTSTKTKALPVLLGAPHDSDPHFSPNGDKLVFRSDAELGIENIWVTEWKGCVKMDVRSSESGDELLAALEVKDSEEDLLAHGVKESSERKRRRLLREGRISARRVTNETYRWVSDARFHPYEPKVIATKWYTSGRSLGAGEGWEYEVTDSSDETISVGSGKRLVGRMLPFGWGPGSYENQQIGPEQFIWYGNDSVIYAKNVIDSNGQYTYSKDVHSGIYSIFSTNLTTQKTTTLVRSYPGGASRPELSRDGRTLAFVRRVRDKEALVLKDLVTGTIHHAWHGLTYDLSAISAPMGTYPSFAFTPKDDAVIIWAAGQIYHVPVSTNTLGERVSGGTPKTIPFTAHIEKRIAETVSSTTDILKLETQDAQRVYAFTELRVNSDGSKTTFQGSGATYVYSNESLQAVPVLHTDAPYYSPSFVSGADELVIHARWSDTNFTTFELANMTSGEAYELTGLPLGRYFSPILCECSGPSRKIAFIKTGGDYLTGDTVATAGPGLYIGDLKLPSSSEKSKEIAVRNVHFISQYPSLDSPAVTKLRFLEGSAKLLVQQSQRAFIIDLTSKPDKFGEFKGKTIATGLMSTELAAAPSGDLANVAIVDFFHIYFAPNVSAEKALWSKPGNSTKGLARLSLDGGHDVVWSGDGKKLFWFLGPYLHSIEVSLLSKCSSEIAKDPLNLGISCTKHLLNFQEIVVEYPTDIHRLKKEASALHQLADDETRANADLLVIANATLLTMESGNLHNDVFRDAIIVTRAGEIEAIVGANEAVIPYGATILDAAGGYIVPGFIDVHAHWNGFDSFYPARSWELETFLAYGVTTLHNPSASNVRGFWERFRVERGQEVGPRIFQVGDVIYGAAYAGIHQDITTMDEAYSALVRIKVEGGPASYSYKNYNLPSRASRQRLLLAARNLSMLCVPEGGMNYDWDQTYIVDGMTTIEHALPIPELYDDVITLYALSGTGSTPTHVVNYGGAWGEQLVWATEDIPNDPKLRRFTRHDILEGLSESTARPKNSFALFNTSESTAKMVHMGLKAHIGAHGEPPLGLNYHAEMFFTSQGGLTNYEVIRAATSDAAKTLGIFSSVGSLTPGKLADFLIFPPGFDLLEGDIRKTRNIRHVVRGGRVWDAETMVEVWPVKGRKAAMPPLNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWB2</accession>
    <name>A0A2R6NWB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWB2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="5828" checksum="DC6D2227D8D95075" modified="2018-06-20" version="1">MTRVSITESKTCMTSAELEYQHGPSGQEDTKDADPGLASLSPNPTARVSIAGMME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWM3</accession>
    <name>A0A2R6NWM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000748">
        <property type="protein sequence ID" value="PSR78365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWM3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036727">
        <property type="entry name" value="Olfactory_marker_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63697">
        <property type="entry name" value="Olfactory marker protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="110" mass="13532" checksum="40A338EF664F3ADE" modified="2018-06-20" version="1">MTRTSSYHLARQAQLARTMRLRLTQTPEQREAARRQEEAEIRWQHHLHQLDLEAQREALYQEWLVGLRRINQQAEERRHHRRERRLAQQPVIVDPEFTILRSGRKVRRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX69</accession>
    <name>A0A2R6NX69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX69"/>
    <dbReference type="STRING" id="98765.A0A2R6NX69"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="314" mass="34936" checksum="CE44CF549C9DFEE7" modified="2018-06-20" version="1">MPTPHQHWLYVWMPLFGAGIWFGTLLAMLITWLAQGRPHYVSQDGSIAYISDVGADILKPLFVTGCVITALSFFLSLAIERWLRHSGRLIADMRRRERVFSCLAILGSFIGGCGLILLSIFDTKRHPTLHRVFLLVFIVGVALSAIFTVVEYRWISHEFVELRKLKRAYIVKGTVATILILLAIAFAIALSQATDVGAVLEWIIAFGYTFYLLTFFYDLRMSKGVSKGDLSRQRLVDMQQRGIPISELTRGHEGDMAPHTNDGNSGGHSHRGGNHAPSITTNDTVGTANGLQYPQQTFAGNDHGTNRYHVNGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXB4</accession>
    <name>A0A2R6NXB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000711">
        <property type="protein sequence ID" value="PSR79081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXB4"/>
    <dbReference type="STRING" id="98765.A0A2R6NXB4"/>
    <dbReference type="OrthoDB" id="3267578at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="82116" checksum="8D22AE8FB925261D" modified="2018-06-20" version="1">MDFDTRKSLHEYSKTLAPCPCHDCKGKLCEIYTIHNHARGKQIRAADDQSEGEAEIVLAVDLLTCMSTRRTRKKRAMEILSNTQDDKQVLVNLSKLLPQNAATAHAYEHKNHASMADEPNPEQQILPAFTSIQREDSPFLDYVNPYIPPTINPTTHDLIPVHLNLPPVESIPRDDSPVLNYKDPYNLPTINHDKSDNTMGMDYDMPIPSAPVHHPDLKHHRPPNPIKTPTECPDENPRTNPRADSVFERLPHPQEIIKTSSTTWYWRSILMLSAWLHLHHGLSHRGIFLFLGTLRLIFIALSLLSVKDDAPTDLRTMFSRLNINDHFLVAPMCPECYCVFLHKLAQDMQCTNCNIPLYKDMATSVLGVPFTADDPFLSSWKTQIHAKKTRKPILQTPIRLPSQLLAELISSSPTMEQGIDKWRHTPSAAGRMDRIQDGAIWKTLPDPDGGKLFDNSPQRDAPEELRVADTLRFDGYRPENLLLCGLTPGPKELNADKLQFFMKAFVNDLLKLYDHGIIVKTADSPEDHIMKTYFCTKCQIQHDELQTVDGININAFKARDPDEHRQLAQEYSKLATKKERDEFCRTDGVRSLEFLRLPYFNPIRMTIIDPMHNILLEWLSAAEKQYQAKLDKWKSKKGEKPKELKWRMHPDDGDNFLNLAAAMKIILARTIAINDIPLAKLRLQNYLRGFHSVSLSVFDYSLRHLALSFFCTRRICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXM9</accession>
    <name>A0A2R6NXM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phospholipid methyltransferase</fullName>
            <shortName evidence="14">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v7062</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="14"/>
    <dbReference type="EMBL" id="MLYV02000696">
        <property type="protein sequence ID" value="PSR79417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXM9"/>
    <dbReference type="STRING" id="98765.A0A2R6NXM9"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="14">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR79417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="190" mass="21106" checksum="3CF3519ED35E9285" modified="2018-06-20" version="1">MSSLVFSSVDWSSPSLWLSVFSIAFNPLAWNIVARNGMSFFARDPPSFKRPTLSSSYPSTEYRNKTITRLFGGNARYGCYFLAIMIFAFGILRDTLYERALKDQPAHALLPAPLNTLVPAALFLAGQTFVLTSTWALGVTGTFLGDYFGILMDHRVDGFPFNVLRDPMYVGSTLCFVAAQEAKSESKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXU6</accession>
    <name>A0A2R6NXU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v6981</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000692">
        <property type="protein sequence ID" value="PSR79570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXU6"/>
    <dbReference type="STRING" id="98765.A0A2R6NXU6"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="16">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="15">
        <location>
            <begin position="260"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="17">
        <location>
            <begin position="368"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="17">
        <location>
            <begin position="510"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSR79570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="592" mass="66098" checksum="E48CE5E7A5AA87B3" modified="2018-06-20" version="1">MAFRLSAGHLEEVQSEGECSDRLSSSSSEEDEQDLTWDDWVSDSMTKLATKSLFDDTILPSVAEEVEYDKKTHGFDLEQTCVRLGLDMYKRIRLINWIRKEKPTSTQASNLQGNEEFFDSDQYLIPASEDDPLLQTQPDDSEWSDEEAVITAKQPSNLSEASRRIRALEKKLQKAQQDLVDYRDFVGGRLNLAGISEALKEPAASTSTHIGAPLRDDDSHYFQSYGENDIHAVMIQDKVRTATYAAFIMKHPELFRGATVLDVGCGTGILSLFAARAGAKRVISVDASDIAEKAEKIIKANGFEDVITVIRGKVEDITLPDGITQVDVIISEWMGYALLYESMLDSVLHARDRFLRPEGVMAPSQTKMMFGLCEAGDILKERITFWGDIYGFDLSEMATDVYEDAIVDVVGPESMASEACVVKDLHLGDITTRQLDFSSPFTLVATTSRRTKIHAFVLYFDTYFNVSGGPVPEDTDVYVVREGDPILAEVWQVGSKPHMARRMSTGDNLKPKSQVTSFSTGPLSVPTHWKQTLFLLREPIVADEGTIVQGVFKCRKSEDNSRELDVEIHYSVQEDAEAKESGNVIVQTFKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXZ0</accession>
    <name>A0A2R6NXZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXZ0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="111" mass="12550" checksum="2B2C0F18AA4F0B51" modified="2018-06-20" version="1">MLATWAVIVLMKRRAKRRAQRIYAQVTAYDPPSVQEHSFANPEWEKPARGPDVESYYKAPELGYEYKPTYIPPVYKPAVLESARNSFEVIPPAIPAPPTVQGHLYPPPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYE3</accession>
    <name>A0A2R6NYE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000665">
        <property type="protein sequence ID" value="PSR80165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYE3"/>
    <dbReference type="OrthoDB" id="2742759at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="405"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR80165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118993" checksum="2C6A493C118FDB9A" modified="2018-06-20" version="1">MSIFEDVWDRKDKDGTIHFFGGGRKRATLALGHVIDLKFDCAPLTEAIHHVSSIFEEFHSSAAGSSSLDDFGMRARAARAKAHAEMEDPSPLIKFLDAILDREDWPEEDDAVFDPYPPPKVQSPRKEEEDSYSGQNSLYTNSNHSPSPTATSDKAREAHNPQPLIVQDRVGYTEQDATISQPQPTASQAVAVAEHPSSPALTSVQMIGNNPRICEANRIGKRLAPASADCATDERKAKRPKRNLKQQNTMLNPPLESEPLKVTAQGLHHYACTTLRAPETRKQLCTEMSGSFVGPMPIEDFLENFMPVGPERMPSIPLVDFSEVAAARSETKMYRPLIHTINKHRLCQGLIFKDISGRAQDGTKLKPDIGGFEGGEMQLYIELKSSEPQDAFYDPHNSGDRIEKQTDLSSKHRGQIIHYAAEQMAVQHRVSLLTISMMGHNARFIRWDRSGAVVTEAFNYVDSPHLLAEFLIRFSGLDAAHRGFDTTVMPADQREIALLSSALEGHANLFGKRLPTQLEEDQAGQQMAYKIPVIIGNGTRTALVVGKPFCQPLSPCGRATRGYIAWDLVQEKLVFLKDTWRVVSPGSLSEREAYEQLKGHDVPHLPTVIAAADVMDLTGNYQRTLTQDFAGHSWCRPHDSLRLLVHHRVVQELALPLSMVRNSKQLVKAIRNALVAIRCAHRTGNLLHRDVSVSNIMLDLEMNGILNDWDHNMTLPSHPDYRPHTYRTVRQHIFFTCNCIVDERILQGHWQFASIALLGDPHKPHEVNDDIESCLWVLFYFSLHFISHHSKHFSMTMFDQLEEKPCHYDQCGLVHTYGGSMKSYAVTSFQFEGVVFDCGPLNYLIRKLADRLDGRLRRRPLSATAGANERDKSDMDEAQPYIELFDEALGGGDWLVEDAVEDQLPPKSALQTSQAHEKVRSASFSNPSLRLSFPTKVMRTSQSLSSTIAGMVMRSGSLPPDSWPTDNVSSASRKEKPIRVRHRHNVKRNASPMGPPPLPVILGERLVNASHNSLAVQFASLDGTTKGVETRPRNLKRPRDEGETEEFLPPMKHPRTGSSLFVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYI6</accession>
    <name>A0A2R6NYI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYI6"/>
    <dbReference type="STRING" id="98765.A0A2R6NYI6"/>
    <dbReference type="OrthoDB" id="2802795at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="9545" checksum="8D04CE10C155622B" modified="2018-06-20" version="1">MKSCLKSPPLTPNCSLDCSPSGSGSASPGSSNIRLPCLRKQVSFCEKEGGLEEFFQADDWDRTPAPVAPKLCYQYVFSLFFCFGLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ04</accession>
    <name>A0A2R6NZ04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000632">
        <property type="protein sequence ID" value="PSR80954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ04"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8272" checksum="351D20CC28E573C3" modified="2018-06-20" version="1">MVKGPRGQGKYWKRKEGNPPSYVAAEKHNYASHVLLFRQSGLPARLSTLSAGNGALSRFQMRTSTKVRLNVDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ87</accession>
    <name>A0A2R6NZ87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ87"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ87"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF39">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="631" mass="67795" checksum="3B61601D9C1D6D61" modified="2018-06-20" version="1">MLTVALYRILKAKWENRHGDTDAANNNDAPQPEAPNPRTPPSTSSQREERGDSSTKWTIMLMVALAIPVFLETLDYTVVATAQVHIASVFNRLDLQSYIGTIYLLTSTVFLPPFGSLADIFGRHVALQVSLLIFMIGSAISTGSQNMATMLAGRGVAGIGAAGLLAVVRIILTDSNSLNANNWQQSMLFLLYTIGYCLGPFIGGELISVSFRWIFAINLPCCAVAGILGFFLLRGRTKGSQPSQRLPSTQSHSKMQSFVDKLLRVDWIGAALFMAGGILVLLALNWGSNEKWNSVKVVVCFVLGGILIVAFLGWEYVLEMQEESPMPSSIRLFHTDPMIPLALFRSLDVCIVQYGTFVSGMIMLVMFYFVAIFFIIVTGLSPTKSGVQLIYFAPGMGGGSLISIQLIKLARQPKYPIILGAIVCTVALGLISMGMDQNKENLVNGFMAMAGVGTGLSIGPLAIHARFSQPEDRVAIVSALSLFFRAFGGTVGLAQCGAVLNGKVNSYITEFIRSGAISSSDAAALSSASSSSSLSSLNGISSLPPDIQAVVREAFRQGTRYAFISLIPWCALAAILSLFLSKIRDRNSPRAESDSEAPEQEIKEEKIGALKEDVGDVAVPPLHAGDVRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZI3</accession>
    <name>A0A2R6NZI3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZI3"/>
    <dbReference type="STRING" id="98765.A0A2R6NZI3"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="476" mass="52774" checksum="7A5BB7E9E6AF96C5" modified="2018-06-20" version="1">MHFSKTYAQLLLSLPPELRDNAIEYRKLKKLINQVVLELTSLGLSPDFLHQALLDTQTANSSSKGKAREGSSSTWVEIRSSQDRKGLPKVVYEINTDSDRLEPRLRLLVNTSEVQSIPAIASLHVLSTPGTAVPSASIIDVEADSPPEPPDSPGLPSSSLVGAGQLAEGDVTGQLASALVDSQPSSEADTQEFIIPLASDTAFFHVLVQALRTLSTHLGTVHEEFMTNLVDLSRSISSSARPMSSTSTFHPYSHSSNPASVSVHTSSIVPLMASKTDLYSWREIFQLYVDTEVFENQSERSRGERSLEDAEGRLELFKRRIADRGFVDGRALKLKESRQALKTFLQLNAFVLDLKKFHFATTEATRKILKKHAKRTALPVSPSVWSRCKSGGTTIVLCVGPLLFYPLIDVRTVQSLSWAHINHRYHRLANVDWALLNFMKDWFPIEAKKKLHQNEEEAAQEQLQELGINPQGCIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZR4</accession>
    <name>A0A2R6NZR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-xylanase</fullName>
            <ecNumber evidence="12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v6329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZR4"/>
    <dbReference type="STRING" id="98765.A0A2R6NZR4"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR81563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="252" mass="27151" checksum="C07BE6B4C1429254" modified="2018-06-20" version="1">MFGQITAANSMKWDATEPALGEFTFDQADVIFNLSQSNGQILREPFNDDGTFGTDVFLSVLGTDYINITLNAARAADPNAKLYINEFNIEFPGPKSTAMQNLVKSLKASGTPIDGIGLQSHFIVGEVPSMAALVQNMEAFTALGVEVAITELDVRMMTLPSTPALLAQQKTDYETVISACMAVSDCVGVTIWDFTDKFSWVPGAFPGQGAACPWDEVCPFYTLIVVISINVEILQNLVQKPAFDGIAIGFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P052</accession>
    <name>A0A2R6P052_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v6175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR82000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P052"/>
    <dbReference type="STRING" id="98765.A0A2R6P052"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="341"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR82000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="620" mass="67327" checksum="2C201C58AA29D0CD" modified="2018-06-20" version="1">MASTYASYSMPPPSLHNNSVQLPSIKQLDLYKPSDQQGSSQQSRPSQSEHGTQQSAHSGRHENASWGRNALSNPQSQSHSPSMPPPPEPSKSHHASHKSEGVYHSQPSGGAGTGSGRSDAVPPQNAVKRGRTEATISASPGRSPHTSYPPYSPQHQQPPSGYHQVQGGPPPQQQEPIPQSSPYPQPGGYPYPPSHHVPRGPYPGPPALHSQHPHAPAGNPYSPSGGPPEQWQPPQPASAPGAPPAPQPGYEGVVRTTPIVPATIETRNAHSAHPMNPLERRHGIIQQIVQHCNTLWGFANKYAQTPPHMQPHPDELRDMHYFAGVVVHLLDDLRRLSLSEEQGGREGLVQVPSADESRPPKRPWEDMSRDDDPAAATNQLDYPDENSQTTAEQDMEIIRSKRATSSGTTTPGQPKSKYRKRSRATPPGKCSSCNIRETPEWRRGPDGARTLCNACGLHYAKLQRKKDKQLGPDGKPVVIDLAMLRASTASARGHHHRQSSEEPNHSQPPPTPPPQQHQSNGQGVSASPYEPSKQPMHPQHPHQQPAPHGAPYQHQQLQPVPAQGPLPASGPQQMMHSSSHPPSHEHPPTPSWSSGRGFPSEQPYGRPPSHSSHAREKQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0W9</accession>
    <name>A0A2R6P0W9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000573">
        <property type="protein sequence ID" value="PSR82819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0W9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8041" checksum="5A51443AAA2943A4" modified="2018-06-20" version="1">MCGIVLALVIFTITALIGMHMYVVTLMNRYIQDGNLRYNDDYGWSTTTNNGSNNNNGIWGDFTTGWGTTNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P161</accession>
    <name>A0A2R6P161_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P161"/>
    <dbReference type="STRING" id="98765.A0A2R6P161"/>
    <dbReference type="OrthoDB" id="3253553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="516" mass="56881" checksum="1BE1940F3055A62A" modified="2018-06-20" version="1">MFPTHRLETPPPTSQFRRPWSPEPFDPNPRSSLDQGGRGAHHDFGHFQQRRERSDVSVEALDLADYALTLARQTNAHAAPGFEPYSAYPPSPHSFRPLSIRDYPPTPPLLSPSTSTSHSHSGASPYSPRSRHRPFSLPAPVPRHPALQTYPTFSSHDSADPLRTPPPEPEAEIDIAQFPAFTRGWYPDPKTNKYDPISRLQLDPFDPSFPTQEYNSYSSLPPLYSSPNVSRSREIGAVPWSSELDGTPVDSEVKEERIRMLEREFAGKNGIGKGEEEEHIIGSVDSKGKLITEGPKKRLAVRCLQTLLALLAGGSSIYAALVIKPPSPPPPASKPPAYVLYILSVITFLLTAYLFFIYPTCCGSRKRKSATSPFTEGPSGMMVLPVSGPPGGKSKKKGRNKKGQGAGEGVQVNLIVDPGMFGNHRDEEEAGDDGSESEYTVPGSYSGRSRGRGRGRRGHRRRSVFAGLAMEAQWKQARKLLKWGMTVDIVMFFAWAAEFVYILIGQRCPSGSFDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1B6</accession>
    <name>A0A2R6P1B6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v5788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000564">
        <property type="protein sequence ID" value="PSR83226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1B6"/>
    <dbReference type="STRING" id="98765.A0A2R6P1B6"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="VTC" evidence="8">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="385"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR83226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="54880" checksum="E5DAC89BC0F9CC88" modified="2018-06-20" version="1">MDEEFQGLVTKGKKTQEDVDGMIQLANEVQYAVLTKKLEPVMRTFYNRTAFQLPGDARVRISLDTELTMIREDDWDGTVRSGSNWRRTDIGIDHPFEQLPDGDKELFNKFIHGCATLLPERVDLVPFWLPQMDVDILKPDTGALQIERPLQSSSRGTSSSERQESSGVVTPEMGIESRHYTEPVSEGEEDEEMDLAPARDEGARIGLRDADVAAAVAFREMSLKEQEKQKQKGGVEGSRVPGVKARDTIVQEVEEDADDEADDDGGAGVDERTPFLKTRKHTGKAPAGDDSKHRALSIDPLAPSSAFDETLRDRLREDVERKRSSKGKKAGDEEDEEGDDEEDEDEERQVGPSVRAVRESERLLERNWSAPPGKRIAVPVRVEPKVYFATERTFLKWLHFAIYIGTIATALLNFIPAEDTVGLISAGLFTFAALVAIAYSAVIFVYRAYSIRHRLADGMYYDKYGPSLLAFLLLGAILTNIGLRLREMIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2D7</accession>
    <name>A0A2R6P2D7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2D7"/>
    <dbReference type="STRING" id="98765.A0A2R6P2D7"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR84231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="407" mass="44917" checksum="A5A9A2AB0CD7DE02" modified="2018-06-20" version="1">MDSMELEREKGITIQSAATFCDWEATLPTGEKEKYAINIIDTPGHVDFTIEVERALRVLDGAILVLCAVAGVQSQTTTVDRQMRRYDVPRISFINKMDRPGANPWRVINQIRTKLRISAAAVQVPIGAEDQLSGVVDLVKWKAIYNKGEKGTEVVESDEIPAEVLELAKEKRRELIEQLADVDEIMGDMVIMEEDPTTEQLSQAIRRATVGLKFSPVFLGSAIKNTAVQPLLDGVCTYLPTPSESLVTAHDTNLPATSPPIPLTPAAAAPLVALAFKLEEGRFGQLTYMRVYQGSMKKGQFIHHARSGKRVKVPRLVRMHSNEMEDIDSIGPGEICAIFGVECASGDTFTDGSTSFSMTSMFVPEPVISLSLKPVGLETPNFSRALSRFRREDPTFRVHVDNESKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8L2</accession>
    <name>A0A2R6P8L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000517">
        <property type="protein sequence ID" value="PSR87138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8L2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6581" checksum="610E65D9BD679313" modified="2018-06-20" version="1" fragment="single">NDTLYEPIQEIGFIGGSASGIEAFQKTFTSIFPEMVEDGRIRYLTQSDWFEFIEAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8S1</accession>
    <name>A0A2R6P8S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8S1"/>
    <dbReference type="STRING" id="98765.A0A2R6P8S1"/>
    <dbReference type="OrthoDB" id="3039272at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="520" mass="53448" checksum="590C04BB1DB59F21" modified="2018-06-20" version="1">MAEMFPGAALATIAPPGQYGRLDSSGDRTEETGVGEGERIRGGDGGVVGTSDGALGRTSESGRWEDDGLMNNGSTVDISPMLDPPPRSPRSPERPRAGSGPDPAAWLGGREIDYTDPVVPVTTSRDRVSPTTPPLPSSGFGMSSSEGHSGDSGIAPVAGTRSEMEHLMPSPVVSASGVLYGSGGSNSGSRSSVHGYALGSGPGSSAHGHGSSSGHGGPASSLDHGAQSSSSHHMYSVPLSAEGRRSPGPSSLLPTHSNAPPTAYRGVDNTSDEEKPKRRTSFLGSPLKWVKNSRPSTASSTSSATPVASASNRHRSGSTTSQAFISPTPSFYGTPKISSPKLASIAMPPAPILIRQPASSASLASTMRPQSPTLASLPAVAFAPYGTIPENSVPQSMPVWPGLGPLVGGPMPSPALTEHSGHQAPEGLLDPTLGMRLGAIGMASTAAISFRDDMDYSRPIGGLDSDILPPPLARKQQDVQLDNNTDYGYSGIFDPSESLLARFSPIVHSGEFFFTAHIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC56</accession>
    <name>A0A2R6PC56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v5029</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC56"/>
    <dbReference type="STRING" id="98765.A0A2R6PC56"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="245"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR88880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="699" mass="78521" checksum="F62ABAE73F290ECB" modified="2018-06-20" version="1">MTGLIWFGTHDYQSFPKARHACDQGDGLDTYTWTEFDAREGGVQVIKDSFNNVKLTTEFLKVPGGNHGGSWVARIKGEPIHLDRISRISTVFYMGVDGLGGLEMETDEDENGLDGPVVFTGSTNDLDDFTIRVVDSPDNNGVTIGNHANAFVDRADKTHFAGYRVAPGHIWQAREHILQSIIQHAKEVIAPYQEHPSGPPDPSFVLQLPNEVFTGSTMYAVQKIFDGPFEFDVFFESASAKQKLTSSLMDQGIKALSKTYNERFDVVFPVPSSYPSSDAAALKEFSKALTSNLIGGVGYFYGTSIVDRSFSYEWDQDDSGNVDDEKGGEKGAKLTEPRALLTATPSRSFFPRGFYWDEGFHLLHIGEWDNDLSLAILKDWVDLIDDDGWVAREQILGEEARSKVPAEFQTQVPNYANPPTLTMAVTAFINRLKASSSGPSAQDLGMDFGMGNQIPLDSANASPIGVHSQYLNDPELALSYLKSIYNPLKRHYDWFRRTQRGQIKQYARKARSRTEAYRWRGRSQDHVLTSGMDDYPRGPPHAGELHLDLISWMAFFTRTMRDIADFVGEVDDAAAFREIERATLDNIEDLHWSEEHQMYCDANVNDDDESYHVCDKGYLSLFPFSLSLLPVDSPHLGAILDMLHDPKHLWSPYGLRSLSASHPESGQGENYWKGPIWIQMNYLALRALYMVRHPSFDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCC9</accession>
    <name>A0A2R6PCC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR89002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCC9"/>
    <dbReference type="STRING" id="98765.A0A2R6PCC9"/>
    <dbReference type="OrthoDB" id="5586203at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR89002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="11560" checksum="6F1EBE571034A0BE" modified="2018-06-20" version="1">MSSNNPSSSKVESPAKIGEQHKEDEQPALGILEEDDEFEEFTVADWDDKHTALGDLKGAAPGVAKSGGDKLWEDNWDDDDIEDDFSVQLRNELEKKKSGEAMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCD3</accession>
    <name>A0A2R6PCD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Splicing factor 3A subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v5060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCD3"/>
    <dbReference type="STRING" id="98765.A0A2R6PCD3"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="707"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR88911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="85037" checksum="35E5B02888DCF768" modified="2018-06-20" version="1">MAHMDGEEGLNGSAREPKYASGLILPPPEIKSVIDRTAKVVARSANPPQFEDKIRENQRQDPKFSFLNPADPYHAYYRHRMEKVIRGEVDDEPAPGKEEQPTPEAVPEKEVDMGLEPPIPEFILDVASINAIDLDIMKLTALFTARRGRAFLASLSAREGRNYQFDFLRPTHSLFSYFNRLVDQYSKVLHAPKETLEQLKERTEEGARWRDLELGKKRARWQHIKREKDKKREDDREAERTAFAEIDWHDYAIVQTIEFTQADAASELPPPMSVQEVENMTLAQKRMAAMIMETTAEDVEAHRARQAAAEAEAAAAVGGAGPGAGYDEDTAMEESDDEDREVQERKKRDDEERQREFERARAIQASSLEAGGPMKIRTDYVPKLGQKSKEKVTTCTICGQQIPVDELQEHMRIELLDPRWKSQRDTLEARKAQASELQRGANVVSSLKNLARTRVDIFGAEEDEEQRKKEEEEERLRRREREKVVWDGHTASKANTLDKFSTNVNFDEQIAAIHRSKGLGPQEANAIGPGIGPAAVPAPLSSMPPPGSLPAPPMQSGASNDPAYSAATVSSGPQPASLYPQPQPVMLPPLHYQGLDAAQPFGYQPPPTGAPMMHPARVAALGAPPQIGMVRSADEMEGMETDSTPPTKRQKVAKLPAGRYYPEADWISMHPHPISLQIQLPNDPSKPELKLDGSVVTIPDLPLNLLMSTLRDRILQHTGSSISASRIRLAYAGHMLTNSNTIASYNLEDEDLLVLSVRERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCK5</accession>
    <name>A0A2R6PCK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCK5"/>
    <dbReference type="STRING" id="98765.A0A2R6PCK5"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="722" mass="78987" checksum="328BE6245C670A1B" modified="2018-06-20" version="1">MWAAYRVVFVANETPEEYKTLVKSGGASYECCPVQRTSLHRVLAKAQHKADNTVLIADETVLTAALGQDGWSELVQEAADYGLRFIPREKLIQAVAHVDHSYIDCSLLPSISTASGSLPDVVLNTHPDEHSIPPSLVRRSVPPEASNSQVAELEPPKRKLTRRFTRAKPTIIGIDDPSILDEDIPDAADPVPEPIIDPLARPSRLKRRFGPGGAQTQQPPPPSQLFSDLQSSLARTDDQDDSLKKFKSLFEETDPDKIALAEQSQTQREGVSSTTQEAGGGRMSVVREEEEETPPVSQGGAKRKAREEGEEEEDLRPPGKRRELEPPPSESSRPTQTQATEKSAPESTTAISKTTTTETLKGAKKPAGGSGGRGAAPGKPDTDTAFLKAVASTKRGKKHEDEFDREFNDLRISKPDLRSGRGAAADEARRQWEALLQDFGDDRDVRGNFMVVEVLEVFRKEEAAGVGGRASGRGLGVASERVDWDGRLDFKKFKRKGTRERRQPVELFVEDEAGYEVNAQLWKGAAASQSQSQSQSQQQRSSNNKNSSQKPPTSQTEPHRLGNNNNKNVMEDTDDVILPKSSRSHTRGAAQTQQPGSSTSTSTTTTSTGRSATRTAKVTPKNQPLFLESDDEDVRIALSPSPAEDNDMEIDDDGDSGQVLAMDEEDESPTLRSTGRRTQQQQQQQVAKPKRAGTKKRPAEVLEDSDDGAAFTGFGSRKRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCZ2</accession>
    <name>A0A2R6PCZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v4948</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR88986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6PCZ2"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015314817" description="dolichol kinase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR88986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="524" mass="57507" checksum="A46AC8E9C6DC77FF" modified="2018-06-20" version="1">MSISLWVLCVKIGLAEAKLGIWQNLSNLEVVAASLFYQFSLYSAVRLAHHGFTLGELGLVCFGATVLFMEMMNLTIARIWPFTTPFIKTYRLPTPLLIYQIALIPGSLLTGFLLSPLLYLSRHIASRPVRRLRFPEQKQKHRRLLALGFYAGTVLVVAGVVGIWTRWCLGNRDPWLWVMFWLLEGKRKWARPLLLAYWAALGSVSVGGWNRQLARSRRYRHRSTASIPGEAPVVPPSPLDMSRANGNGSAGGLSDSSLSPSPASEGLTSMGISFANLPNLPNLPNGATVATDLLDAADKHVPTLSVNARRKFFHALAVAMFLPGVAVDPAFTHLSFSAAFALFTFAEYVRYFALYPFGAAVHVFMNEFLDQKDSGTAILSHFYLLTGCANSVWFEGPSRLLLFTGILVLGVGDAMASVVGKRLGRHRWSTNTPKTVEGSAAFTASVVACAWLLRLLGFTEDFSIVRYGAVATLGSILEAFSVQNDNLTLPLYMWTPQGDGDSRLVMGAYPRLDSAPVTAVWRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PFZ6</accession>
    <name>A0A2R6PFZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000495">
        <property type="protein sequence ID" value="PSR90477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PFZ6"/>
    <dbReference type="OrthoDB" id="2996761at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="204" mass="23686" checksum="B56D0D2981753CE4" modified="2018-06-20" version="1">MSSATSTVDRSVAHLDPIFKPRWHRYSAAEIEHIVAITPLDELPATLDPPPVRSRRAPMPPVMLYGWVINQDHWFEYAKEHGHSVTMKVISYEGENDPNFELDEDAEELPPRVIIPTVDEHRSVCCALWTIMHNLGIKPVDYYPVKATLASEEFDRLVVLTDNYHDDDSLTEENLEKLQKILGCDDVPKWYPYTYFEWDRDCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ80</accession>
    <name>A0A2R6PJ80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PJ80"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR92203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1315" mass="145586" checksum="7E75EE7DDF7EE0EC" modified="2018-06-20" version="1">MTSLPPGHGYDLDPAKAPNQDFLQNQKDLEFVASSFLEIIAASVPAFPSMFREICAHIGQAVNKVWPEAKFSALGAFIFLRFISPAIVNPALVDVDAPSDPIMRRGLMNIAKIVQNLANNIFFGKEAHMLPLNDFLSANIVNVTRFLSEINKYTPPQEEEQDEWLDTAYDDTDTIVLHRFFDKHADKVGKELLSAASKASETETDEEKATGTGKRSWNAICNALVETTQVSLIPNMSPFTSSEHPEYLDLMSRFSHRDTSPVHHLFVPAVTPQDQPAVFVLSLAKVQVEILDLELLLFYIFKTISAPLYEKRNFEVIFDWTGFPPSAQIPMHWLKFVYEILPSNIRARFRTSRTLIPNAMALRYMRRLYNLTNGASMASSHTLHTSLVELLRCYSGDISLPSLSYVAEQESEPGDDFDEIFMRNNHSMRVPVILRVAQSHLRITTMKATAISNSMSCRATEIIPLADISDIYNVATGHDANEFIIRKIRHGTTLYFTSSTRDSVVKAIRSAKGSMRNVQIPVFERFSRLSNVIATLLHIGMVNIGSDNEELRVASYDLLCSVCTYLDFEGKPVVPTKSIFVPGRAGPFVIQLSEKLASFSPQLTLDFIAEVAAGMEKTSVSQRIACLQYLSPWIKNLSHFTNPTDHLYEQSGAKFRDCVRILIDLTLADQEIHAVVQKCIWTEVGKLDSESVNTILDELMRAAVDGGIGSQRCELVADTMASLTSINVRGRIGSRLRKVMGKTSSKPSKSLPENVHWNEIACLTRLCLVANYLPKNAAHVHLFIAEGAHYVSLVAGTGQILVRTSVYGLVVNVLHSIYISKSTSDSVSPEIQALLEDCASPEVLKLFGLARPTSTSDYVAYDPPNDKQQLDSLEKLGNLLVRMMNCISPSQALLNVWRARWMSLVTSSAFQTCPAIQTRAFITLGILATSDVDDDLLYQMLVAFKTALEDYDDSDTTAVVSMLRCICKVAPSLPPKSRYLPQLFWLAVALIQSSNVAVYIEAIQLMRATLDTMAQQGAFKERGVAPTLLDGRQHLEEFACQIDQILGLSFDSSFSFSLSAVIFKGVRHQNLKEYAEGALRSLLRVTVQSCSDHSHTEDSAGSPICADLLGFFIALLPLSTTSGAFRKLLQEANMDVSWMSEEIIPVEDDDLISRVPFALLGITDGASALYVTSFISAILTTAQGDDTETEILFTILSDIANGYPEVISTTFESLQDQIKDTFATASNPNTLSAVSNVFRVAMQDSRRTINVRGSTSTLSTVEEANGYGLVRSHYNALDELGMQGLTNGYQFMAAGRPQSITITQWIAQLVMKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMT6</accession>
    <name>A0A2R6PMT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn-dependent exopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMT6"/>
    <dbReference type="STRING" id="98765.A0A2R6PMT6"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="117"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="281"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="676"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="562"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR93735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="83994" checksum="0D309EF90FC6C371" modified="2018-06-20" version="1">MAGTLGDFETAKDFLALLQTQLGAVAPESQPIFSAGTTASRNATLSIPTLDTPTAWIDVYYPVMNTPLNHSVEILGDDGLAVWSASLEEVADETDPEAGKYFDSVTTFHGLSRSGEVKGKVVYAGYGRQEDYKALVEKGVNLTGTIVLVKYGGIFRGLKVKGAEELGAAGVLIYSDPSDDGSVTEENGYLPYPHGPARNPASVQRGSVQYLSSYPGDPTTPGIPAYENSTRTEGENIPKIPSLPLSWANARVLLQEISEGGLNRTVSFVNHVDTRVIPIWNTMGVIPGHIKDEVVIIGNHRDALTCPQVMGATDPSSGTASVHEVIRGFGALLKEGWKPLRTIVIASWDAEEYGLIGSTEWGEDFADFIDEYVVAYLNLDSSVSGSRFRANASPSLAHLVRSTAEEVPHPTKPGLSLWDATKDSGILHGQVNEEVAAMYEAESQQADNLGVTPLGSGSDYTVFLQHIGVASTNGGFGSTLQDPVYHYHSVFDSVRWQEIYGDPGFSRHVAISKHLGLQALRLADSLVLPLNTTHYSLELEAYLDKVESIASTTSLSVDFSSLRDSLHTLQSASSDLDEEKEEAEAQLKKLIKKIVRRKLIKHKLRKLWCKIRKIFKKPCGHKHELQSVNHITEITSHGGQVVKPRVGRYPVWIKEQQKHHACRAKEHHLPKRLRKKLSEAIKRIRTVNKKLVAFERGLISEEGIKDREWYKHLGVAPGKWLGYGATTLPALTESFTIDHDEKLAKHEVKRLKKLIDELAEEIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNR8</accession>
    <name>A0A2R6PNR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNR8"/>
    <dbReference type="STRING" id="98765.A0A2R6PNR8"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR94682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43593" checksum="BAB526905EB17EDB" modified="2018-06-20" version="1">MSMSILKVACRTANPAASKISHTCLYWAALSHAIGVTCTPSPNPTEDTFTATGAVDTSSSFATLALEYPATAVGINQSSSSSNDFNYSKPAVVHQGPWGRYRWTGTQTLVYFAHNSDVEFQKCYVSLVENLNVEDVECLKYSLSKGLGLGIVLGGSIMKVPQLLLIVSAKSARGLSLSAYTLETLSYAITLVYSYRNSFPFSTYGENFFLTLQNILITFLIIHYPASRLTRPRSSSAQRLTLAIALTGVAGFALYSIPPATLSALQLATIPLSLFSKIPQIRQNQRARSTGQLSAFAVISQIVGCLARLFTTAAEVGDLILSAGFALALLLNCVLGVQMWAYWGKDGKEASIPVVVTHTEKEKEKIPAAAWQQDGKVEVVVPPASPATPGVRQQPGRRWARKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVG4</accession>
    <name>A0A2R6PVG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVG4"/>
    <dbReference type="OrthoDB" id="3261465at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="61002" checksum="B9DABFDF46C5E268" modified="2018-06-20" version="1">MGTTLSPESYLRYPVQRRGESRMYQTRGSKHRKKIAGADAILVQTEPETFERYMELVLQILRAERFNYFCVDTEKLESGYKPVGSLNKEDFVVPTEVPLETSQAVYRALKLLSTLVDECAAPYGVLTDEVVSVVMERDSIVDKRAMQVWTYSADETPLRLILAACFYKEAINWTLCRCRSLGNSILCRGALQSPDQLRTSFTQDTSILTATKRWFADFDMYTMQRVREAWNEFSRWKDYVQQQAKDNPIVPGMMLSVEVGAFFRAYSRHRSPYPLVPLPPDTLASVTRFSRPRNSEIDDILLKSDSVQFKIAENKRVGPNQFSQVFFGRLAGCDELLCFKVYDERHFDIPEDNTTDYHFTPAEYRLTSVNNSEDLVRREEAAYDRLSHLQGTLIPHSYGFHLVTLPDGWQAYGMLMEYIPGVSLGDYATSGLSPAQQIALTTSMRHAVRAIKYAGVSQTDWHVNQAICSGLDPDFPDIVLIDLAFAHLWLGDDGGAHPTRDVYDVYEMLIVDFNIDMDIIRRYWVPELEYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ48</accession>
    <name>A0A2R6PZ48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heterotrimeric G protein alpha subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000420">
        <property type="protein sequence ID" value="PSR99325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ48"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ48"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR99325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39606" checksum="B655A790760E752F" modified="2018-06-20" version="1">MGACMSSGAIEVSEEDKRLHREAEKSLKEAKAKLAHQVKVLLLGSGDSGKSTILKQMRLIHRVPFSPQEIESYRQLVFNNLTHGLKYLLDAMEDMNLEVAEEHGQSVQLVEDAQDIRDGQPFPLEYLDALKTLWEEANVQKAWERGNEAALPENLSYFFADLDRLFEPTYVPNEQDIVHTRARTIGITETIFHLRDHEMLMVDVGGQKSERRKWIHCFQDVTSILFLVSLSGYDQCLIEDKDANQMQDAMTIWDSICHSQWFKQTSIILFLNKDDLFEKKIPHSDIKNFFPDFDGESGDARAGREYFRRRFGRLAQKANQKEREIYIQYVFPNSSGRPDRGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEH4</accession>
    <name>A0A2R6QEH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000364">
        <property type="protein sequence ID" value="PSS06511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEH4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="15084" checksum="E019C27E4F443862" modified="2018-06-20" version="1">MSSTDNLNITVFTVFGAKERSVMIGVRNVAALWRYVIVTWKARFVSAVHEERLNLCKTPYGMSPRSKEEKRIIRYSFQNLDNDTYHGKRRSASGIKCEILNPRSYNAQKRPQGIHLKHCLAGDVHTGNRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QET1</accession>
    <name>A0A2R6QET1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QET1"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="6">
        <location>
            <begin position="442"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="5">
        <location>
            <begin position="857"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="552"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="827"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="927"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="368"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS06838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="947" mass="105526" checksum="42304B4F05159AE0" modified="2018-06-20" version="1">MAKNIEYSIRGDPLEQHRIRGDPLEQHRIQLEHGLQHTDLSLHLSTGDYSDVEFPRHNSSRDHDPWSYRTDDDGPYIADTISTAAHHASALTLSAGLGGRGARRDISVSGAEYDPDRPVPGIHSSAFDLNSKFPSMTAQFDPLVVDDSADLDLTNRQVAALRSSSSSSSSSRPNTPLSPRPKLSDALHSVSFSPKRPRNVQPIASKPPRPRVPRKPSVTVVQDDDAPRAHNSSYQQSLSYAAPMEPEVNVHPPTPPTAENTSRFTRMARGLTRELEAEQTRFHPPDVAPTAQSTIRKPAKPRQLREQKSHVVKTPFRDRVHLPDVTGLTSAIASPGRIDWQYLGYDAKDDGEIDARLVHTLSIVHSKLKHLESENSISRRRVRELELELEECKKEVALERTKVLEREQIITQQQRDRLAQSTTKTQEEESRYKEAVEEKKALEALIATLRTHLTRLTSELSHHSVLLEELRTLRDSDVRALKEKSRDVDQLRQEVERLAGEVEVLRGVVEEGLKERREVREQSMERSREGSSRHSSHSKSILQEIDDANKTHAGHLMDGSESEDDGSSSGRSTPSPTPSPCHNRTRTARTDAATVASSSPGTGTNGLTSESRPFLHTEELERISEELSDRRVEQSASASTISLQHQQQRPRSQLSVNRGGDGSPVGWVRRSVSVSGHHRPRGKGNGDSDAEGSNAAAVASAPPVPPPAAPTTNRVGSHHQQQQYRERPSQQPKPHQKRSFTELHEKHPAAEGPRAPLPAVAPAPSTETETPFPQIRGAQLERLFFSAPEHNAETCTVCHRRARNRYGHEDAQHDGDDRRNLGQRFRDAETEGEGEGGHGVGKGRGKGKERDCAEGQERVPPQTVVVRVLRELEDDFTHYKGIYVELADQYRIIDAVSNVAKRNVLAGHLKDVIDILEQKVREFPPSGPLDEEQMILSQQPKWGRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R767</accession>
    <name>A0A2R6R767_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v3081</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000273">
        <property type="protein sequence ID" value="PSS22615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R767"/>
    <dbReference type="STRING" id="98765.A0A2R6R767"/>
    <dbReference type="OrthoDB" id="2757440at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSS22615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="165" mass="18991" checksum="47E45A11D47BED0A" modified="2018-06-20" version="1">MVHSDRGGEFLSKDFTNFLEKEGIVRRLIVHNTPEHNGMAECVHRTIFNTVRTLLAESSLPPFLWGEAHNHAVYVYNHSPRSFLQFKTPFEARYGVRPNCTFLRPWGTCVLVKMDATSKLAARAIEGRYVGYDFMSNGVRVYWPERHSITVERTVIYLTNDIIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHR7</accession>
    <name>A0A2R6RHR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHR7"/>
    <dbReference type="STRING" id="98765.A0A2R6RHR7"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS29580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38298" checksum="8DFAC587820855D7" modified="2018-06-20" version="1">MSSLRNSLHRRNHKERSQLSHRSRLGVLEKHKDYVLRARDYHSKQDRITRLRQKAAERNKDEFYFGMVNEKTERGVHVQDRGNVALPVDVVKVLKSQDENYMRTMRTAGLKKIDKLKSQLTTLADLVKPNPDEDDEDQLNEEELEVLRDAGLVARPAASRRRRKSSSGKHIIFADSENQARQYASSSSKATPDLDQDMEDGESDVETGWRSQAETGKSRSKGKKKAVQGDTDVAALEVERKEEASQHRTRLLKELSARLTRDKQLRYAEREMEMQKLLMGKGASRKMKGVERVEDGDKEGDESDDDKPRKKVDEKIWKPRVYKWRVERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHX0</accession>
    <name>A0A2R6RHX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nop52-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHX0"/>
    <dbReference type="STRING" id="98765.A0A2R6RHX0"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS29624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36150" checksum="05D1FFD13ECDC4B1" modified="2018-06-20" version="1">MPTASSSKEVPPLAKYLASTDKATRDKAIKNLSAFLSTESTNALPKSEMTKLWKGIFYCFWMSDKPLVQQALASEIAEIVLNIPNPSSSLEFLRGFWETIVREWSGIDQLRIDKYYMLVRRFVNASFRMLIRSGWDQSLCSEYNTILTDRGGPLCPQDTRVPTSLAYHLTDIYLEELDKALGSSSSPILPAPLSTLITPFFALAALTTVNTTYKRVQDALLEPMFTALSPRQIDHTKGDTRSPKRARVEVLYEDIASNACLSDPKKEGAMEMGFVRKALLTYMFDVASKPETRDANRRKLYALWKSMAEDADEDGEEPAIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLH6</accession>
    <name>A0A2R6RLH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000243">
        <property type="protein sequence ID" value="PSS30876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLH6"/>
    <dbReference type="STRING" id="98765.A0A2R6RLH6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS30876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42599" checksum="F7C6AF08CD9F2353" modified="2018-06-20" version="1">MNHPGHVHQRQRKLMSPAFTAPQLKSFLPLFRRISGKMCQQWNEEYFAKSSESQKIAVNQWLARVTLDAIGEAAFDFQFGALDNDQNEVSETYKNMFADSVMHPSMWNTIFRSFWRYMPSTVLEYIAYIPTREYLRFRGAMQVIGRVSKQLVDEKTKSYSAGDDTRKDAMSVLVRANISENPKTRISEDEMVAQMAVLTLAGHETTANTASWFLWELAKHPEFQNKLREEIFAVRSQISARGDSELTVEDLDGMVYLPAAMKETLRFHPIAFHLSREAAKDDIIPLSKPVYGKSGETMSEIPVTAGQSILISICAYNRVIEMQAIMFDLIENFKFALAEDKPEILRVPMGIMGPMVKGKMHEGVQLPLRVTPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLJ2</accession>
    <name>A0A2R6RLJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000243">
        <property type="protein sequence ID" value="PSS30879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLJ2"/>
    <dbReference type="STRING" id="98765.A0A2R6RLJ2"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015317710" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS30879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="30908" checksum="F0E7CC6EDFCB2791" modified="2018-06-20" version="1">MHFLLALLPFVTSAAFCQNIVLTNDDGWAVAQIRAQNNALIAAGFNVILSAPAENESGTGSKTAIPTTLNQSCEFQTCPTGSPAEGSDPNNPRINYVNAFPVDAVRFGIQTLSPQFFGSAPEFVVSGPNVGTNLGTVVLNSGTVGAACEAAKEGIPSTAFSATSNSQSSFTTLTTDPTSSASEAAVIYAQLATSFTQALLASPARPILPANITLNVNLPSTTGCSSASDFQFILTRNIGNSADTDVTTCGTDHLPDEDTVVTGPGCNIAVSVISALTKTDVDATTQGAVLDRLSDFLSCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLZ9</accession>
    <name>A0A2R6RLZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLZ9"/>
    <dbReference type="OrthoDB" id="2337158at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="160" mass="17190" checksum="26540C7944C76E32" modified="2018-06-20" version="1">MFLTDTSTSKGKAKPQARTAPRPLAARPSQQTILTENSSAAATPAATPTLPTPSIARKYPALTATEIIRLLAGSVTSIHADPSAAVRTLQLRFYILSAFGGLQEQLPSEERDSEWEKGIHNGELTKAIDDAFHPPAGAPREDQAWAKDLKAVLTAMGWHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPK0</accession>
    <name>A0A2R6RPK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000212">
        <property type="protein sequence ID" value="PSS31947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPK0"/>
    <dbReference type="STRING" id="98765.A0A2R6RPK0"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF27">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS31947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="18060" checksum="B8E3AC4A09BCF57F" modified="2018-06-20" version="1">MAEELPEPRKDLPKAIAAQIILGTLTGLVYAVALMYSVSDLTGALATRNAGTFPLAAIYLQAMNNNISATMGLLFIVLLSVWIAGCGCYVTNGRTWWSMSRDGATPFSKFFSRASAKRSCPIEATIFCGIMTSALGAIQAASSTAFSDLAGSFVVLSTISYGETFWAFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ79</accession>
    <name>A0A2R6RQ79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ79"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ79"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="749"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1156"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS32180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1187" mass="131809" checksum="3DEBDF285CE689FA" modified="2018-06-20" version="1">MSTTLPLFWHLSSTSKKERLDASVKLVGALEHFQAQFVPKSSSEGLSEDEEDQGHSAGSRGDGLDVLNAQDVSYSIRRLVRGLASPRESSRLGFAVALTELLSRIDSVTCSQIVALILDSAKTQGSSTGQEERDVLFARLFGLTSVIQSGLLVRDSPLSTSASSAPAASTLSSYQELISELVALGEKKSWIRESAWWTIGLAVDTLGASEVLWKDEALESTIQSILVENKIWTPEKIALTLKLQKLCPSRDWSKILSPTFKHSHLLSTGNYSTIARILKEFSMDEEDEKEAPKSKSGSWKPQVHFVWDILLDEVLSEDDSESSTRGSFPEFFRILVDESLFSSTSSPERKYWGFQVFQKALPRVREADVPMLFTKNFMRSWINHLSNSDRYLHKIAKQVANDIQTVVKNNPRLGFTLILQLTGVHGSHQFDKLTKTKTVETLLTTMDNEGIQSYIEYLLKQVNDEQASQTTDIQALNARRAWIVDQLAALIRNGAVPKDDKWIQTVLDWFVIHGLFTVFRRSEKSKTLALRDIPAPIFSDELRKLCRSKLLSCLAELTGQTTVITTGDKTVKVAAVASDGQFWVSKVLSSIGRLEKDGKHVSPLSEVEEGDKAIHGEARALIERLNKISDEQREAAKGAELLVSATLLHHYCTDDEEEADAETLQSCIDGASRMFPAESKKTKKSRRPSTTTEDEGPEPIDVLVDTVIGFLEQATAYMRAVANQVFSLLSSAVCESTIDLILAQLERREPGEIADDDADMENEPEDDDESDEDNSGSSENGDLEDDEDLDDAGDPELRQKIEEALRVNGIHAATEDSDAESEEETMDDDQMMAIDAQLAAVFRARADEKKFGKGVDAQREATHYKNRVLDLLDSYIKKQPTSPFITRLILPLVELVVSSGTDEKQLADKATGILRSRIGKSKDMPSTVEADQAGEILREVHLRARKALSADVLTTLSQCSLFLVRCLTHAKDDSTVVKAYRDSLVDFVTRKASRLNANFFQDFIKRHPAVAWGFRSDLLDVIGKAVNGYRRTQVFQLLQTLTAQLPTITNRDTEILEFMPGLRNAVQESVRDACSEESLTAAQVKELLKLALSAIRQTKRVASQEQLHTIWEPSSWETLSSALASADRFKSSTALQTMCKQISQLVTEGKLSKAKAPGKRKVDSLEGEEEVAASPKKVKRKKTKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVI5</accession>
    <name>A0A2R6RVI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVI5"/>
    <dbReference type="STRING" id="98765.A0A2R6RVI5"/>
    <dbReference type="OrthoDB" id="3241493at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="291" mass="32939" checksum="C9E79F3108FDD93C" modified="2018-06-20" version="1">MDAPTLFETSTKGDGQGPEYNLDSLFPAQQTHIFTSPHPSASNMLTDDLPWPELGNVSRGATRGNQGQKGVLTPPDNEGRSTLQLRVQPGVLPVRLNRQATEWYRTLDGEVNRALKLTKTYWRKARRRQDYDARADQDHMELHEWLQQLKDKVMSHLELLMQKGEIQGPPYIMPDNVELTFLRKFIERHAAGIPHNPRLRQNYLNGNRSPRTIPQYNDTKFSEGSSTSPAMSWEALDDRDKASQGHDASPTLASFSDNVHTVVGEVESNRAFRVGRTLSSSISNIILQEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZF8</accession>
    <name>A0A2R6RZF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v1570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZF8"/>
    <dbReference type="STRING" id="98765.A0A2R6RZF8"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="9">
        <location>
            <begin position="288"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS35415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="571" mass="64635" checksum="F56234FADB4AB16C" modified="2018-06-20" version="1">MGKMYDLLRGACLFCHRFKTSRFVICKFIAKLRLLEHGFLIAAKLLDDMHVSTRKKGKLEGDEDEDSIDTYEDYEKRVNTFVAVHLASASSSKRDNYKEGQVFQERNNIIHEFLKTTLSKKCQNPACGAHGYTFRKEGHTKIIEYDLSPKQKAQHAIIDLKRPNVLLDQQSEKDTSSEANNGPDDDREPTTESESESESEPEGEDVWSENDETDVHARSNAGQQLPKSASGKVKTARGRNERVMAPEECRAHLRRLFVNEAVMCSLLFGRHGPFAPLSPHNLSFASADIFFLEVIPVSPTRFRPPAKMNDMLFEHPQNELLARALVTSYRLRDLNENLRAASDKSSGIDDVSRRKLLQSLLDSLIQLQVDVNSFIDSSKNPAPVRQGKLPPAGVKQLLEKKEGLFRKHMMGKRVNYAARSVISPDVNIEPNEIGIPPVFARKLTFPEPVTPANIHELRQLVITGPHGYPGATMVEYENGHLQFLEKLSVEQRTAIANQLLTPQEGDRGFRGTGLQTRTAAINKKVYRHLRDGDQLILNRQPTLHKPSMMVHKARVLQGEKTIRMHYANWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZN4</accession>
    <name>A0A2R6RZN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZN4"/>
    <dbReference type="STRING" id="98765.A0A2R6RZN4"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="111" mass="12194" checksum="EE3EBEA9BBAAAAC9" modified="2018-06-20" version="1">MTNDAMGESSTSQKKPSNASKPRKRFVGSKSATPSKPGLASVVANQIPPEILQDTQLNSAIKQLPSNYSFEIHKTIHHIRKNNSKMVALQMPEGLQMFACTITDIIERADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZX0</accession>
    <name>A0A2R6RZX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycoside hydrolase family 3 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000120">
        <property type="protein sequence ID" value="PSS35547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZX0"/>
    <dbReference type="STRING" id="98765.A0A2R6RZX0"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000009">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF117">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015361207" description="Glycoside hydrolase family 3 protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="5">
        <location>
            <begin position="71"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 C-terminal" evidence="6">
        <location>
            <begin position="330"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS35547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="59412" checksum="6881C8A549D5A809" modified="2018-06-20" version="1">MFAKISVLLAFLSLSLRSIAKADGSSHVEVRDDLHFPFHARATNNDGSLPVYKNSKSSIEDRVNDLLPRMTLDEKVAQLIQGDIDGWMDMSDPLDDTLMFNQTGLEQMMAQKAGAIWGGYLAKWDKIVFAITVGQKYLMENTTLGIPALFQTEGLHGFTDNGTIWPSPIGLAASFNTDLLQQAAATIADEAEGLGYSQVFAPVLDLSRELRWGRVEENFGEDPFLTGEMGHAYVTGLQAGRRRNASSTAIARMASTCKHFAAFGSPQGGLNIAQVSGGERELRTMFLKPFNRACVESLAIMTAYSSYDGIPAVANTRTSDYHLDKPLFDLIGSLADLLTDIFGDYVFFNASLNGISPLAGFTQFLSNTSTKINYADGSKLWSNDESEIPAAVSAAQSSDVAIVMVGTWSLDQTLLWTPGTNATTGEHVDLSDLGLVGAQLKLVQAVKATGKPTVVVLVSGKPVAEPWIQANADAVIQQFYPGELGGLALAEVVFGAVNPSGKLPVSFPRNVGTTPVFYNYIKGSRPLDPGSVLDDGTLVFGHQASPPSMAYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S404</accession>
    <name>A0A2R6S404_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS37017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S404"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="44"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="462" mass="51592" checksum="346030859CD43193" modified="2018-06-20" version="1">MSKQVPYSKDQSVPIVSQLNDDEDMESSYVENKDPDSTDSLESLVQAVDKHDTRIIESWKDELNNLLIFAGLFSVVVTGFTVGSLPTLQKDAADTSTQLLTRISLQLSSFTITPGFINSTVSDMPMMTTASFQPSPCAVTVNTLWIVSLALSLIAAFFAIAVQQWLRRMPLPSNLSAQQSIKLRHLRYDGLIFWQVPGIVSFLPLLLQAAVVLFLIGLLLLLHFVNPTVASAFTAVFGVSMTIFIIATLIPLIRPRCPYKSPIIPTTLLAIQWCTYPITFVAGLFAFIAVLIHNIIHVVVFSNDPPPLRGVLAVARQLLVYTRGFGAHMIVDVSVFWKRREYSMLQTPQDNSDAKALSSAFSALPRRSLEEVVRILQDLTLEMRTRVVLRWMAFDLGNCDYHIDLLYTAGPSHINPNALKRVDAQFSAKFRKLMLACLPKRPSLYRHPDIAAHNKEMGKARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S421</accession>
    <name>A0A2R6S421_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS37012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S421"/>
    <dbReference type="STRING" id="98765.A0A2R6S421"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="64790" checksum="2FC6D726426A023C" modified="2018-06-20" version="1">MAKVSTLDRLLNNRTQVSVPIMGAKYGGYAQRDAVTQRLKGFERTSPRSIRPLPGELDKVFVMFSSVRRRFPQELVNMVIDNLHDSKSDLSSCSLVARSWTPEAQLHLFRRVCVNAARTPFTEFLDFLSFTPRGSLVGRHIRCLTLIGCLVHGRAGSATLEMETLKEILRYLPALAYLCLDCLSIVRLNQDRIVQEDSSLKDNTLNWKAALPLRTLKHVNLDGLSYTPGDIPTLLEILALSGDLKELGLMSYIQFSSPRSPAIFVANTNTRETLARVKLERLRLRVGPSPAGGCSRYKLVLPCAMLQQTTLLSSLTYLEIGYVNATDGGEITTLLRHVGKSLLYLALDLRAYETSSNNDDSGLGLVSCTALKWLHIQAFFNLGETTRPILLERMLRELLSATPRATSMGLELVLHRNSLRWFGELDEVVCQYAPDRGLMSVKVFWQEPADDRSWKLAQQRGRELSKEEQSRPKEIRDIKQFIEVATRKDATEARIKKIAPRVAGGKTKTKFKIRCTRYLYTLSLDDPEKAEKLRQSLPPGASPALHSYLYDLIIPFPEFPGLRIIDVEKDAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S437</accession>
    <name>A0A2R6S437_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin N-terminal SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS37015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S437"/>
    <dbReference type="STRING" id="98765.A0A2R6S437"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="3">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="7657" checksum="09E266A6FBA867EF" modified="2018-06-20" version="1">MPAPRPSQSAEVARAAALQAEFNEKKWVWVPDDKDGYLAGWVTKEEDEMGEVIMAAGGEASLPKAFIHIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4H6</accession>
    <name>A0A2R6S4H6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000079">
        <property type="protein sequence ID" value="PSS37188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4H6"/>
    <dbReference type="STRING" id="98765.A0A2R6S4H6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="178" mass="18822" checksum="98A011BC4FF89539" modified="2018-06-20" version="1">MAPLSIFVEADVDPAVLDSTDAETIREYPNEGGEELHSPPPSGSTTPTKTFTDTSTPTNTVRKSRTFLDLTPLSGFFKSRSASNSRVDTKAQPPLEDIRTEATPIANGSGHPQEDSNTDDEDDRRTIRAGASEEDIAEGKSSATTRPNGTLNGAAFGHAPPAVEKVADKLQSPQVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4P4</accession>
    <name>A0A2R6S4P4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4P4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4P4"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="48"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS37264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="476" mass="51947" checksum="0FB47F474F110510" modified="2018-06-20" version="1">MPGDETRKKIHDDSDSESEEEEIQEAIPIIEIDPSKLTPLSPEVISKQATINLGTIGHVAHGKSTVVKAISGVMTVRFKNELVRNITIKLGYANAKIYKCENEACPRPGCYRSYRSDKEDNPPCERPGCGHRMKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNETCPQPQTSEHLAAVEIMKLENIIILQNKVDLIKEAQALEHYKSITAFVKGTVAESSPIVPISAQLKYNIDAVNEYIVKRIPIPVRDFATDPKLIVIRSFDVNKPGAEVDELKGGVAGGSILTGVLRLGQEVEIRPGIVTKDAQGRNQCKPIFSRIVSLHAENNHLQFAVPGGLIGVGTKIDPTLCRADRLVGQVLGAVGKLPKIFSELEISLFLLRRLLGVKTEDKKQTKVSKLVKNELLLINIGSTSTGGRVLSVKADLAKIQLTSPACTEIGEKVALSRRIEKHWRLVGWGSVQRGTVLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S503</accession>
    <name>A0A2R6S503_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-coumarate--CoA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S503"/>
    <dbReference type="STRING" id="98765.A0A2R6S503"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="464"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="62402" checksum="CC7C5140FF71D25C" modified="2018-06-20" version="1">MHLKSPYPPVPAVPDSNIHHCLFNPLPGQPTAPDYTLHVDATSGYKRSWFEFRELVLDGATALASSVSTGGLGLSSEAGDMVGIFSHNCLDYIALVNSLLAITVPIALLSAYSTSYELAHALRTSKANRLFVQPSLLPKVLAAAKEVGLPSDHIYVLEGRVDGRKSFQNLVDNVRSRGITRVPPKPATKTTLAYLVFSSGTSGLPKAVMISHGNLWAVIIASAMAKAVDDKMTQEEPPKAIPISLLFLPFYHSYGLFMGCLRVFNAPATNVIVPKWDTGVVLKAIPRFRISALPLFPSAMHQLVNHKDIERTDLSSLVHIFTGAAYMPPALEAKFKKLIKTKYPMFEGYGMSEMTLSVARKSWPEYFGKPKPGCAGVLAPGVEARIVRADGSEADVDEPGEIWVRGPNMALGYYNNEKATKEAFVDGWLRTGDHLKADKDGLLYFVDRVKDTLKVSGVQVSPTEIEDALMAHPNKLVEDVCVAGVSGGRTSDEKNPRAWVVLTEEGKRRGPETTLKMLDEWTKKTLSQYKWLRGGYEVVDAIPKNPTGKVLRRVLQDRYEQAKASKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5M1</accession>
    <name>A0A2R6S5M1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMR1-interacting protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5M1"/>
    <dbReference type="STRING" id="98765.A0A2R6S5M1"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMR1-interacting protein 1 conserved" evidence="2">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="33183" checksum="0076F4098C5D1B26" modified="2018-06-20" version="1">MSLTSPLLAFRCCSSSMIATLARHARLNVDAPKPKPVPIQGTNIKLDSPETIEQWIAERKKRFPTVTRVVEKKQKIEEAVSRGQLFLEDPRFPKNKRRRLDGDGARNTDTRGLRGRGRGTGRGRGRGQGGGRGRGTDSGYGGRLAENAESPIPSGEDVTQSPTVVERSPKAHIVDDAEVFSSDSDGSPEVVSSRVQPTIIEQDAAEPEIGTQKAPPNSSKGPLAGGAVRKSLPKQPKRPPQNPFASRPALLRNMTVSNLSQAISFLVGNDFLDNVELRAGQGSEKMIEVIAESNSTEASESQSQVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S627</accession>
    <name>A0A2R6S627_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S627"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="5">
        <location>
            <begin position="24"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="6">
        <location>
            <begin position="1077"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="1877"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="2974"/>
            <end position="3080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1661"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1661"/>
            <end position="1670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3105" mass="347329" checksum="64CD2AD96E3C81DC" modified="2018-06-20" version="1">MELDKVSSHAQGTLQANDTHRSAGQLTLRGLRLKRGALDKFRLPVDVIEGHLGRFTLSLHWMNLGNQPVEILIEDVYLLVVPSSETSYDPEEEERRSQAAKAERLQNAELLHMEGQVEQGQDAPQQQGLISSLIAKVINNLQVTVKNVHIRYEDKFSVPGHPFSAGITLAGFTAASVNDSWIPAFIDSTAGVIHKLAKLESLAVYFDTDARSLAGLSHQDFVEKFTDLISHGSHVPDHQFILKPVTGEGRIKMNNKSNKDTPKFDVQLLFDEIGVLLDDNQYRDVISLIDMYHFYIRQHQYRKYRPSQPELGHDKPKALMKFAVTAVLDEVRERRRKWTWAYFAERRDDRHRYVDLFKKKQLGPLAPADTDMLDALERKLSYEDLRFYRSIARSQLKKDLAVRKKLEYEKKAQQQTQARSGWTGWLWGSSGSQSTSTTEEPAFTGEMTDEQRKQLYEILDYDEKAALAASFETPRDALKARVHAKLERGSFALKSDPHGKSTEIISVVFDRFHASFLQRPDNFESSLSLTGFTVHDGTTENTLYPLIVQVQDSQEVASPQNIEFEPQDPFFFLKFEHNPLDQRADNALTMRMRNMEIIYHKEYIEAIYRFFKPPSSQLESVEALLNVAGQTLEGIRKETRAGLEYALQTHKTVDIQMDINAPVIIIPEDVTVERCSYLVIDAGHIAIESELADKKAVQEINAKRKRQYSDDDYQRLESMMYDKLSVRLEDAQFVVGNDLQLCREALKSQQHGNLHLLERISIDLQVQNSIIPTAYNLARFKISGHLPSLQINLSDTKYKSLMRLVDVAIPHFDDDDDDGADASRPALERGKSSGFGLRSGFFGQTDDEYHVDDVDVDDEGQVAHTHDDGDDPEEFFEAHEGDDGQLPQITQHIAEVDFRVDTLRASLYKSSDGNERELGTVCLQQFFLAFALAKYTMTVDVKLRSLSMDVQSSPGEKPIHFISSREATASEDLLTIRYTRVQPESPQFMTLYEGINQNVDIKVTTVVVRAAPEPVVTLYDFIMSTFVPNSNASIRATVPSESAEGKNLVLIEDTVQQPEAKIQVVVKLAGVQTILMNEDIRIATLSMSTADVHILLRPNTMRISGRLANLALSDDSDLQTTLPEFKQILSIEGDNVANFQYLTYDPKDVDNSAGIKSSMYLAAGSLRLNYLEESLHQIYIFLAKLAKLKGLYDAATQAAAQSVSDIDRMQFEVSIKSPIVVFPTDVERSSDVLTLRLGEFNARNSYEGLANTINAGLKGISLSSTVSYDGKPSMLKMIDDIDASASILQTSGIDRTHEFDKPDTQISVTISDVKLHLTQLQFRRLLALSQSIPRVLTGPKDISSAQNIPSSNEQLIEPASSETTIDLQPELREMSGSDRPKTWTSVDLFVTLDVVKLHLYDSLTSTEQNLRDHGIARFALNSSTLRAKMLQDGALEAEVVLKSFTMSNTRPGNSKFREIIPAAHHTRNQVMVLYTMSSGADKSAMAVVTVDSPQIIFAIEPIMALLEFFTSSINEDRQIEDTIPNVQSDETASSPQSSTLNVRFDLHDVSVSVLENDSDVESRAIRLSIKQIFLSQQGILALSVERLGMSLTRMGKSAETVRFLDDVDLTLSLDSRSSASHRVTNMQFTSKAIVFRASYRDINLITTIVNKAIALYSASTETHGSTSDGKVTQFAKDGRASGRPTKTLGPSSQPVGNAKVVLSKEQFQGSCDGFRLVLIGDLHEQPLLHLKVKPFILGAKDWSGELQATTTLAVNASYWNLTNSHWEPLFDPWTFTALISKDPSTGGMQATISATERLNANVSTAFIELAIATANMLGKEGERMLRKARGSYAPYKIRNRTGCSVCVWSDVDGSTNISDVIMTEIANEKSIDWRFDDWKTMREHVSSTAHNSIGLQFIGKQWDQVRSIPVDREGEYTFSLRPKTERYACRVLCEVVVQDNVKVVTLRSTFKVENQTLYPLEIMLVDEGGQPVRSLEKIAPGQDYPLPIEGIGSNRIKVQPDQGFGYKWSPSIRWEDLVTRRSFTIRCPHTDQNEAPFRFQAFADTNANDVNTKKYPKITLKLRAPIELENLLPYNVDYRIYDKDADQNWRSYLRKGGVMPVHSVELGHMVLLNVHVQETVFKPSDFSIINTDGSADFDVETRLTLHDAKDRKLDLRLNYVRYPNSGGAFKVQIYCPYLIVNKTGLPFSVRPWRTNRLGSSQDVAGDTTIESLSLPVPFMLSHPSDQGNNFSFKVGESMWSQAIGFEAPSADSLLSIPSQSRANEEINVGVSWSEGLGKYKLTKVVTLAPRFIIRNDTLEVISFREHAVAPRGRATLSPGERCPLQFMRAGEEKLLTLAFSGLNAQWSAPINVEDIGSVHLRLKRTNDSSEVHLICADVKLAGSTIFIVISRAEESWPYAIENDSDYSFTLYQSDWDHPDTADSGRTVPTYKVANKSRADYAWDYPASRGKKLILSINGSRRAIDVMEIGDLVPFKFVGPQGSRTVSLDVRAESRMQVIRITNYNPQLSLYKPTRRNTLSIAQQDSMSGSQEAFEAIQEEIPPTFTLKIDFAGLGLSLINRKTVEVVYFSIDALKFDYTDSPVAQAVNLACGSIQMDNQLHDALFPVVLQPTPIPKDSSTVASLPTVQGSVIWLKDQEHGVTFVKYCSILLQALTVQADEDFLYTLYDLTKLKGASWDSAQEDILILQPENIPEPEATANGEELYFEVLELQPIKLSISFMRTERVSSEEQLSIRNPFAVVINAITMAVGNINAAPLEMNALAIKDMRLKLPDLQDRILYHYRQEVLRQLYRILGSADFIGNPVGLFTNVSSGVADIFYEPFNGVVMHGNQELGIGIAKGAASFVKKTLFGVSDSVTKFTSSVGKGLSAATFDSEYQMRRRMTQRRNRPRHAIYGVTAGAEAFANSVASGVEGVVLKPIEGAESDGAMGFFKGIGKGLVGVVTKPVIGVFDLASNLSEGIRNTTTVFDNPARDRVRLPRHVPPDGVLVPFSEREAQGQYWMRDLDNGAYRKEAYVAHINLPGSDNIVLLTTSRVISFWSNRLRMDWQIPFTQVQGVTIEDTGVRFAHKGGKEQDRFVCIPEKTSQLWFFNQVASVVKAFNAQRRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6F8</accession>
    <name>A0A2R6S6F8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S6F8"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015361210" description="SH3 domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1357"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1414" mass="145110" checksum="F41BEA07EFDBC948" modified="2018-06-20" version="1">MSSLCVFLFLYPTLSLASLPLIDFNRMGKVGLAGAFAGLDLFDNSSSTVSFDSSTSTLLSRAADGSLSRLGSTNAGGSILAGCALGSTFYIAGSFSSIGGTSANNVASYDPSSGSFAALGSGGPNGELHAIFCDDAQKKVWVGGQFTSPSPAVAVWDTGSSSWSAPPFGGLSGASAEVSSITTNSSQSSLFFSGSFVTLFGNSSQPINDTNNPNVPFSTGATPFSSSLVPIPLGNAQITASPSSTETGFSNIMNILCPAGSDGPGNTWFAQDGGKAVITVREFAYLTARGIRLGNTFLNHGTTGFSVTTIPDNTVQTLQFTDPNSGQNSTCTDPCPLLTDPSVPYQDFLFDDDVAITGFQLTLEEWTGAAPGLHILQLLSSGAFASSISADNGDSCFSPNPSNTARTGNWTEKDAHTPIAGTTQAVLVSTVNVGTPSSQAPTFTWMPYVSAAGQYNINLLVPGCTDLEDCALRTTVRITVFPGDGLSPVVTTVSQQNTDDATTPIYSGPVVPSSSSFSMTIIMALDDNPVGSGQDGQFELVADRVQLVLTSANVTGTTTTSGSNNSTASQSGFGFFEWPLSSTSDVNAASTLPSTAETSLDNVGLELLSALGGSQSLSSSGSIISAVAHHPSGVIFLGGSFNLSAGSSAGASNIVLYKNGQLNALPNNGLNGPVTSLVLDGDQLYVGGSFVDTASASTQAKLAGVAMYDIKRNQWSPLQAGLNGAVSSLTFSDELILAAGSFSGINSPSTGQDDAAGFAAWNVTSSSWVNAGGFLVGQMTFVGNSTASAKGQTQTQLLAGNVAAAFQFGASGFVMLQNGGNDGTPQITPLSVPLQSDPNASSSSPTKRSHVHNRRSSITWIPNISGFFKRQSSAATLAPLPAPAPATAPAVLAGAYWTNSSSSKEVVIIGGNFSFTASSGTVSQNVAIYDPDEGTLTALQGNQLNGTVRSLLVADNELFIGGTFTVQGTNFNGFAVYDLVRQEWDATGSQPLQGSSGSSVVVRSVTTSPSQQNTIIVAGSFAQAGSAVCRAICSYDIPTKQWSALGNGIQGEVASVAYAGNSQDLVIAAGSIALADGTGANVAAYTIANNTWSPIGSSSELPGPVTAMEVNAGNSSSIFAAGRSTDGSAPFLSFWNGQAWTAFGSSLAGTTDVSQMTMVPLQNTHEANSIVESDRMLWISGSLSGTSFGNVSSALFDGEQIIPYIVSASSSGTPGTIASLFFSISNFSFTQRHFLATGIVILISIAIAAGVVFFLALIGILWTLFSRKDDKIDKFDPADIEDDDSTTHRPSSLLEHINAATRTTILGQSPFGPHDGEKSADAAALAAASADPFGPDASNYVRAETPSDAAGGILGSEEIRPAHARYSFDGAGEGELAMTAGQDIEILDDGDAAWWYARDMRTGKEGVVPASYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6N1</accession>
    <name>A0A2R6S6N1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000018">
        <property type="protein sequence ID" value="PSS37926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6N1"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="705" mass="77007" checksum="91CCE55E32AE5FB3" modified="2018-06-20" version="1" fragment="single">LLSRSRSVRKLLCFHYLITHDVSDDFDDSNVQYLEPPHDTGAELFPYAVTEDQESDNATSHCSSSVSETSRDRPIETAINSTAVGNSVAPGRMDANYVQSESQPQKQLFALIIGINDYDHITPKLCGAVADANAIEEYLQRDLRVPSSNITKLLDKEATRAQIIDELKKLSTNANIEPGNPIVIYYAGHGAEAKASWVDKGQKIQCILPVDVCSSPAEGSTNIKGISGRTIGILLNQITQQKSNNITVILDSCHSATGTRAVQSRMQPRGVAVSFVFLQSDDEDDNDILPSLEAVSQARALQAQPEPEAPFADFYHIGLNSHVLLAACGKKESAWEDKSKRRGLFTQALLKVLQSAGPTLTYSNLIARLDEIPPSQNPHCVGNNKDRILFEGVHRELPLAGLTRVCYDAKTSHWELKIDAGDAHGITEGAKFSLYNDRNPSSNPLLTLVAKKTLAFSTILCPDSDATHSSFSFETGVVRQTHAGIGEGLRLFVADQSLASNAVSTWGLQERDGGKRRIEFVGTGKDAKVVLDADASDRADKVVFDVSDLKGDMRRFYKTAKPTADDVYAVIKEAAHYCYHLYRVPTIPILRKKVQISLFRLQEKPGVAKDSEGLDPSLVRGQGPLYINYGGSSGEPQTFYLRKGQMSAVGFLKIFLSTRPLDLSHISTQAARAGGTLKLDNSNAEGHWDAVTITVNILNEPTQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S700</accession>
    <name>A0A2R6S700_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S700"/>
    <dbReference type="STRING" id="98765.A0A2R6S700"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="7">
        <location>
            <begin position="424"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS38023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="509" mass="57339" checksum="0F0BDA3D9B144D80" modified="2018-06-20" version="1">METLDDLLITIPNCRHVFTVETLDGHLSMDEYYLRKGIDGPWIALQSPPFGFRRPPTCPTCRTTITSPRYGRIFKRADLDILENNVASRMSQSLSNIQSRLQSLSKTTLEDNVRTTATNPNLGVQKPTGKNVKQIQKSHAALLREMRVTPAPVKSLDPSGDLHGIPVPEARAWRSVMHGLLTCYHDVVNIASTRSAHTYAWEASFSYLYQKEIDLALQDPERAPRNPHEYAMRLARLNVGQPQPRADMRFLVEAFWTTITIRLTLANLTRLWLSVVSSRRSSYPTATRRMWEMYISLLLRACAKDGGIALNITLQSDSRRQAVKTTLLLMRIEIEQFQFNIEGARENGKFSATRLDIADRAAKKVNEATIQRKETIDSYRAQRSDDEVEVQWLTENFSQPAQAIVDEWEKIEKSLRMATFYEPVSLGEMEGIVKAFNFSHTGHFYKCPNGHTFVIADCGGATNQSSCPECGAAIGGTGHSLLATNSRAMEYEEISRVQGAAHSPWSWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S763</accession>
    <name>A0A2R6S763_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v73</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S763"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="102" mass="11409" checksum="1C1AB3C04B803DF1" modified="2018-06-20" version="1">MQGLRGMGDPVRITWAYGQAIPYLLSSRIKRELIIRGLSKFIDKLRSGDNQMPLGEFWDLERTAFVLSNMVDRSVSGVPEQSIQHLPSNKPPVPGYGSYSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDJ8</accession>
    <name>A0A2R6NDJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001353">
        <property type="protein sequence ID" value="PSR70413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDJ8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7409" checksum="C3CFB77F2AC08A4F" modified="2018-06-20" version="1">MSRATEQAALLAIHLEDCTHWAIVFPEWLCQLSQISHGKEGFAPGEESTKPQRLFLEWIRGSMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDV3</accession>
    <name>A0A2R6NDV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDV3"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="15284" checksum="44FB1E586285B480" modified="2018-06-20" version="1">MGAIQALCSSWKLKCLADRSRISRVAPVTVDNSPADIEDELAPFALLSLLTTSFTKFLIRRGIDSYHRDEAGLRALGRQRTRKNTPVKRLLTPSHIHRGLLHNAPQSAEDAAVLLALAPLGISLPNIPETAGDDGDATAAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE46</accession>
    <name>A0A2R6NE46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v13659</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NE46"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000066">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="895"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="975"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="76"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="416"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="753"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR70508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1321" mass="142872" checksum="15206C2663E3750A" modified="2018-06-20" version="1">MPHGTKLHHPGKDAGHDLVPVLSKHDQQPQSLDEKGSHNGDPGEKPSPELSTPDLRPVSFTSLFRFATKGDLSLNALGLVAAAAAGAAMPLMTLLFGNLVQDFVSFGTVLAQAKLGDANAQAGLPAAADHFKHTAANDASYLVYIGLGSFVCTFAYMYIWVYTGEVNAKRLREHYLRAVLRQDVAYFDNVGAGEVATRIQTDTHLVQQGTSEKVPLSLSFISAFFTGMILAYIRSWKLALALTSMIPGIGITGAVMNKFVSSYKQASLKHTASAGSVAEEVISTVRTAQAFGTQAILACLYDAPIELSRVASVRGAAIQGAGLSVFFFVIYSGYALAFSFGTTLINRNEATSGEVINVFYAILIGSFSLALLAPEMQAITHARAAAAKLYETIDRVPLIDSASEAGLKPETCVGEITLEDVRFNYPSRPNVPILKGLSISFPAGTTGALVGASGSGKSTIISLVERFYDPLSGSVKLDGIDVRDLNVKWLRSQIGLVSQEPTLFATTIRGNVAHGLIGTKWEHASEDEKTTLIKEACVKANADGFISKLPMGYDTMVGERGFLLSGGQKQRVAIARAIVSDPRILLLDEATSALDTQSEGIVQDALDKAAAGRTTITVAHRLSTIKDAECIYVMGEGQVLESGTHRQLLADENGPYSRLVTAQKLRESDVKQVDPLEADDSTVRDIEDGSRGDFSKEAADEIPLGRIDTSRSLASEVLERRRQEENKSEQQYPMIYLFKRMGAINSDNWRRYLIGGIAACLFGVVYPAFGIVFGKAVNSFSELDPHQRRHDGDRNALWLFLIAICAATAGGFSNIYFGISAAELTGKLRSLSFRAILWQDVEFFDKDENSTGGLTSGLSDKPQKIEGLAGVTLGAIIQSISTLVTGFAIGLGFAWRLGLVGIACAPLIVSAGYIRLRIVVLKDQKNKKAHDQSAQLACEAAGAIRTVASLHREEDCCIAYSNSLEGPLRNSNKTALWSTLLFALSQSMVFYVIALVFWYGSRLVASQEVTPFHFFVTLMSTVFGSMQAGNVFQFVPDMSSATGAATDIINLLDSKPEIDAQSTEGGVPNNVQGRIRFENVHFRYPTRPDTRVLRGLDLTVKPGTYVALVGASGCGKSTAIQLIERFYDPLHGAIYLDEQPITGLNVSEYRKHIALVSQEPTLYAGTVRFNILLGATKPESKVTQEEIEEACRNANILEFINSLPDGFDTEVGGKGSQLSGGQKQRIAIARALLRDPKVLLLDEATSALDSNSERVVQDALDQAAKGRTTIAIAHRLSTIQNADCIYFIKEGTVSESGTHDELLEKRGDYYEYVRLQDLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEY4</accession>
    <name>A0A2R6NEY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001300">
        <property type="protein sequence ID" value="PSR70947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEY4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10293" checksum="9FC4C5717CC44B1B" modified="2018-06-20" version="1">MAAAQDKNPRLSAKITGILTSEPPKAALIILWIYSKTEGDVDEHGDHDMVTSRLFAFKNVGPSWTFSRFGPVSPAFQLLLLVRLLAREAKGSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF56</accession>
    <name>A0A2R6NF56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001297">
        <property type="protein sequence ID" value="PSR71017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF56"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9413" checksum="C729B7553B8D15AA" modified="2018-06-20" version="1">MSQPLKTLVSLNLPHTASLHGTDLVVILSVFSKTRMTRIIVPGLQLLAPSGPASRYYFVGKRIIPGLHILSDASISRPACPQTYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFC2</accession>
    <name>A0A2R6NFC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFC2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="167" mass="18222" checksum="420FEA3620526776" modified="2018-06-20" version="1">MSEPNKLPDSNVVLPGFEATFSDVVSRFPVPPTNDWQQSPTSNLDQYSDHTTLKTPTGYQDHHRPSGSQNAISRAVPMSVLFPSARQTGDSNQYSVGIYDSPPWLYPTLTTHPLSKSTGSAPSSPGIASSLTESDDASKDPDIPRVPISRQRRILVCSICNKEFSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFQ8</accession>
    <name>A0A2R6NFQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFQ8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="223" mass="24080" checksum="8DFFDB08C4608198" modified="2018-06-20" version="1">MDDSTPIPSFYTGSQATSLGSMYTGLKIHQPKPIPHPALRTVGLHSALPHSSPIRSPNTMDRNHPAVNLPVRPSDRPRVTLAADVGPYSSFPSAGSSGLCSLEEGRRQPFNLCNHHVACVLCSCYPVSSLSPLPHMPGSFPGEANVPPNHGSPLRNNRMTGRDIVISRALEYHIKKIQDAGYIVYIKPIGNGATNEEDNALEDSDAFIGSNDDDFIESENKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGG4</accession>
    <name>A0A2R6NGG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v12698</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGG4"/>
    <dbReference type="STRING" id="98765.A0A2R6NGG4"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR71431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="440" mass="48381" checksum="0F925BC495F6B97C" modified="2018-06-20" version="1">MSPSTSSMPDFTGRLVNDGQYQLTKMLGSGAFGVVYQATQLATASSSSKSFKQFAIKVLKKASMSSRDALHVRREVTLHRIMSDHPNVVTMHHAFEDDDYVYVVLDYCRGGDLFGKICEEKVYFRNDELVKKVFLQILEAVHACHRKRIFHRDLKPENVLCNKDGSKIYLSDFGLSTNSQVSETFGCGSSFYMSPECIGKEAGFLAYSNRANDIWALGVILVNMISCRSPWAKALTSDDCFCDYLLNYDYLREMLPISEGANDLLRKIFAYEPMERITIPELRKAVIELDTFFMTDDEIAHGGEIVQMAASYCGLHIEPAESMVAAKADNQTTMGDIPRSPTSLFGDILASPLISATAFVIGSLSDDSCWTSESSSSGDDSAGPVTPSTHGQDPEVVIPELNIELGESGEAKPASLKRVVEKPPLRVVNVAVPDALVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGG7</accession>
    <name>A0A2R6NGG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001282">
        <property type="protein sequence ID" value="PSR71475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGG7"/>
    <dbReference type="OrthoDB" id="3250770at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015309013" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7574" checksum="D08F7082D5EDE299" modified="2018-06-20" version="1">MRFLPIIFATICLARFVSAGIYGTSPIASTVWSAGSSEFVTWMDDKSVPRLADMGNINVELFGGDDVRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH59</accession>
    <name>A0A2R6NH59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001246">
        <property type="protein sequence ID" value="PSR71725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH59"/>
    <dbReference type="STRING" id="98765.A0A2R6NH59"/>
    <dbReference type="OrthoDB" id="2792799at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="20982" checksum="26F6B1DF963408F1" modified="2018-06-20" version="1">MGQTENGIYEDECEGMHPDTINRYYGVDCGSNETRRRQSHTGAGHPPDESDLDSDSSDNEDNTPSIGDRIAHDQQPNIRHEPIPVPDNFTPFVDEDSSQLFHDTWEVYKDINVLPPNGYGVHEDEMEEGGYESFEILRMGKRGGKEMTISLPEHIWRRRAEQWAKGLYLMNHIVYSVDNSEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHP0</accession>
    <name>A0A2R6NHP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v12254</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001236">
        <property type="protein sequence ID" value="PSR71869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHP0"/>
    <dbReference type="STRING" id="98765.A0A2R6NHP0"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="452"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="697"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="997"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1038"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1043"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSR71869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116827" checksum="0C794655FFC3B2F4" modified="2018-06-20" version="1">MQMPAVTANAAATPSPASLKASVVAPADGQFDITGLFVADKATREAAASQLAALAEKDGPAALQSTGFTDAVVKALNDKKSPAAREGAADAVAILSKTPAMKALEPLFIDSGVYAALLETFADKMPAVRTAAIEALKTYVSAMNPWATALVLPALLHEIKTAGKWQMKTGSLAVLDQLTTCARTQMARLTPEIVPVLSEAIWDTKADVKKAARASLEKATALISNKDIERFIPALIDSLINPVEKVVPTIGLLSATTFVSEVDSPTLSLMVPLLARGLSEKLTATKRKVAVIVDNMAKLVDSEVTVRPFLPKLLPGLLKVEQTIGDPEARSVVGRAIATLRQVGNVPTGDGSDLPPLKFADEKQLAHSLIAIYKKLGANPVPSVASVEAMYASHLAANLVNGKEFDTTQWQALVGYLKFLATNPDPVSVANEWVVKSATIGEDDGDVPEDEEEGEDLCNCQFSLAYGAKILLNTATLRLKRGHRYGLCGRNGTGKSTLMRAITNGQVEGFPSPDDVRTFYVEHDIDGSEEETSILDFILSDTRIQAGKEEVIETLASVGFSDERQAQSIGSLSGGWKMKLALARAMLFKADILLLDEPTNHLDVVNVAWLESYLTGLTTCTSIIVSHDSSFLNNTITDVLHLNRFKLKRYRGNLEAFMKQVPEARSYYTLEAAEDYQFKLPDPPLLDGVKTKEKSLLKMRKVGFKYPTQTKQQLYDITLQVSLSSRVAVLGPNGSGKSTLVKLLIGDSEPNCGGETWKHPNLVIGYVAQHAFHHIDNHLDKTPLEYMLWRYQTGEDLEEMMKESRQITDEEAQKMKEGGVVVVEGQKRLIDEILARKKLKQSYEYEISFKNMSSSENIWMPRDELIKRGFEKKVLEVDTREAQRLGLLRPLVRREIEKHFADFGLDPEFVSHNTMRGLSGGQKVKVVLGAATWRRPHIMCLDEPTNYLDRESLAALIKALKEFEGGVLVITHNRDFSESLCKEVWAMRDGRLEASGHNWVEGQGAGPRIDKKAGEEDDQYDAMGNKIEAAKKAKKLTAAEARKAKKDRMARRKRGEEVFTDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHZ1</accession>
    <name>A0A2R6NHZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001229">
        <property type="protein sequence ID" value="PSR72005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHZ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHZ1"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR72005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="328" mass="35094" checksum="4A5C6E3249307E3D" modified="2018-06-20" version="1">METEPRITEAEQEGGCSPIPQPPISSLLRRLPFLTRGSQRARDSPDSSSVHVPNYVWCTVFTAVGGFLFGFDTGSIGPVTVMPQFQQHFFKTGGSIDPTTQGLIVSSILLTASLASLFSGPLSNRISRTRTMALGAIVFAIGSAVACASGPLAQLFLGRCIAGAGEGLFLSAITVYTIEIAPASSRGRLGSVVQLLITMGIASGYFVCYGTSRIHTSLSWRFPLGMQATVAAIFAAGCPFLPHSPRWLHHVGRHADARAAWEKLGVSAADVEKTEETAEREETRRGSFWDETKQMFKKGIRGRTALGVFLSAMQQASGIDGVLYASFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI26</accession>
    <name>A0A2R6NI26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-dependent oxidoreductase 2 FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI26"/>
    <dbReference type="STRING" id="98765.A0A2R6NI26"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006130">
        <property type="entry name" value="PRK08274.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="87"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="516" mass="55537" checksum="700935B52D586786" modified="2018-06-20" version="1">MSMYAFDCVVVGSGHAGSCAALSAIDSGAQRVLIVDKCPEEWVGGNGYFTAGAHRTVHEGLQDLLPIVHNVTPDMASKIDMDPYTEEDFTSDIMRVGEGKPNPALVKAVVESSRSAIAWLAERVKVPFTLSFNRQAYLVEGRQKFWGGMVLSVQNGGKGLIQAHQKAVQDAGVDQWFDTMAVELIVEDGSIAGLVVRREGKMLHLKTSAVILASGGYEASSAMRKMHLGKEWERAKVRGTPYNTGDGIALASCIGAALAGDFSNTGCHSTCWDAYAPPDRGDRVLSNQYTKSGYPLGLMLNAHGVRFVDEGADFRNFTYAKFGRAILFQPGGFAFQVWDSRVTPWLRQEEYGDDVASKIWADSVEALAEKLEPEGLENREDFIKTIHEYSDAARGFQAEHPAKKWDPAVKDGLSTQSSSISLSLPKSNWALPLAQPPFLAVKVACGITFTFGGLAIDPETAGVLSQESRKPIRGLFSAGELVGDLFYSNYPGGSGLTAGAVFGRKAGRNAAALAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI34</accession>
    <name>A0A2R6NI34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI34"/>
    <dbReference type="OrthoDB" id="3270652at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="508" mass="54449" checksum="F24C161C3BD64257" modified="2018-06-20" version="1">MVLDLLGWGVPPEYLVSCGLSREIVYYVFIELNLRLPINLDVTGLPESTAVFGSPEPMSPPSHLNQRSDTGAGHATTPPRPVHAHPSLPRKPPAPRRTSASAPAEGPASQLSATAPLFVPSASTSIPISGEQPSLFDMEQQRRQELLARKAVLASRKLKNAAAASSSYALANEAKDVDMAPPVVPTKTVEDFLNSIPAVSTDSKSPGGDDDMDVDAIPGLSANRESPQSNASTPRSTSVSDIITISEIVPPPRTESGSPEGSTRNSKERSVDGGSALLDDKSDTPSGQHSGLHSAGSRRATKRPVAADFVDMDPGASRSQGYGYGATYYQSNAPRKKPQSFAGLTGTRRMVINLSDSEDEVEDTVNGYGDYRSTYRPQAHYSRPPSRLGASNSVDSIGSRNGIVSPAILLEKEQEIRRMRELIAKRERARLGKLTTVREVTIPYLFFEPDLSRQSSNMSTPPPSASDNSVMNTPVSVKQEEDEGIASASLRLPSLETREATVVPRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIZ7</accession>
    <name>A0A2R6NIZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001193">
        <property type="protein sequence ID" value="PSR72357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIZ7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6691" checksum="5381F316BA27389D" modified="2018-06-20" version="1">MPHVGCRLEAELHNDHDVGARKFAVCREEVKLVRVDINDFNRSLVFDLDEDPGHDLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ39</accession>
    <name>A0A2R6NJ39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ39"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ39"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="46"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="546" mass="58363" checksum="6ED846E5231B33AB" modified="2018-06-20" version="1">MSREDLVEGEGGFEGVESRWLESVGETERRTYLRAKQYQLQYPPNSTPTDITLSQFLSIQEKGVSAWSFEPDFEALSSLLVHARTEITFLPDPSSATSVQSNLPLPKLNEVYYWEVKMFDLPTTTNVAVGLATKPYPSFRLPGLNRFSVGYHSSGDKSHNYPFTAASCGSGLKEGDVLGVGYRPRTGAVFFTKNGRKMEDAYVAFNNYNLFPTVGADGPCSVHVNFGQSGFVFIEANVKKWGLAPSSGTLAPPPPYGSERGSILLAAGGDITPIQSVAGSPAGASSRSRRSHRSRRGRSTLASSTPVPSSPLGNSPISSPTPPDTPPPPITPIEEEPEGTETGNPYPSSRRYISPTDLPFHASPNADIPSSPTQQGSHSDSSSRSRSSGDSSRPRSPSTRAPGANQFNTPRRQPFTFTHARTGSRSSCSGPELAIQVHPPPESPMSPDPPTPDVSDIHLQAMASSSNATADTLSAANVAVVLEAPEHAPPAYSPLDAYTYSEGVQLDLPAEIIAAALERGTLPPTVLAPSLSTRSDRHRSRRSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ83</accession>
    <name>A0A2R6NJ83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ83"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ83"/>
    <dbReference type="OrthoDB" id="3269550at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="760" mass="81487" checksum="2A51C04CECC29F93" modified="2018-06-20" version="1">MPSATTSTASNKRNSLQRLSHIFQLASPSFARLNFDASSASEHKKPVNKSNGAQLASPTSTSSTSERSGASVPTGSITSTPESQVSSPQSPSFSSFPTSPSSDSAMPPTANDFAASEKLALMRKVRKLARVLGETPLPQTVEEVEARSPPLSPSRRLSDVPEDSRPSSPRPSVAASVKKTFRRSLTLGHGADVTASKQDHEAHRVKSLTSLRPSLNLPSSSRLSPRESSYSPIIFAWPGGEEHHRSKSQDSHDRSSPPSLLHDFDSFAASDLHRTRRDSTASSVLLADQNSEQVRRNRAAKLARQLGESVPPDALVRAASPPPLSMPPPFINTDEVPSSDTSPVRGPSPKLSGRRPMSLDPRAFKKLGMTSAPSSPQPPPSPLRAGPSVTGTLRRSRSMWARGGGKENTGEHEDTDGWGGGDLSSSAFGEPMSERQRVLNVRRARKMAQLFGDNPPTALFQITNFGSTSALNLSIDDTSTNSSSNITVMGLDDGGGGGGGYGNPRRDSLATIISISTTSLSASLCGTLGSRRLRDSYISIITTSSEVSALLLAEHEQAFEEETDTNREHRRASMSSDPEGLLDATSHSHHHHTNIGPDTSTTPPQQLLLIPSSASYNAHQPPRTPPTPPPFSNFIPSAMIQPVTAPPPPPPGGDSSSIATPEFQTRRRRAAKLSKFFGVDVNELVEVLPSEGTITTIVSPSVLAHEFSLFPEAGERPTRKASTTVSEAKNRRRFLGLNDNDLKEMDMPEVIEQLRRIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJK9</accession>
    <name>A0A2R6NJK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJK9"/>
    <dbReference type="STRING" id="98765.A0A2R6NJK9"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="15967" checksum="391885669409F7C9" modified="2018-06-20" version="1">MVVVETTEEHVLTVRGMDARPSITNTEGTAHNIDNKDVEQSPKTSEVPDPYAFRNGLKSEDELAQLRRTKLGKRLEGYQRKQNDLIEALLKPMEEHTEDARVEEEATRLPVSFYLHINLGDSPTPCKGQNRHLGKFDRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKH5</accession>
    <name>A0A2R6NKH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar membrane-associated protein Iml1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001127">
        <property type="protein sequence ID" value="PSR72863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NKH5"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="1">
        <location>
            <begin position="105"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="518" mass="59590" checksum="8354E399FC7A56F4" modified="2018-06-20" version="1" fragment="single">MSVSRSESLAPQYGRKRSNTVQSVLKSTLSALPLNYGDHKLLTTWVHDTKDSPTVIFNQGHWPGVAEGDMLQLSVQPSFDQSSSLLFIVPKDETVKKTEWEAEYVEFTFQDQYMGRNEMWRLDQHLVGQCVYVDQEISFIGVVSARVHSIYIGGKSVSTGYVTSKTKMVYRSLSAKVTIFIQVCRELWEFAGDGERYNEKIAHSFLPTLFSKWRESGTTHIVTLVLISRVFYDASEIDYAEGPLRQDDEGRWYKDFFKVITDLEVIHEWKPTLVSLKDSFWAFQRDILLAHHYHSSAVKDRDNVRLVGQLSYAHDGPILEALNLSFNPMETHYIDRSLSLTGSSTIIITPGTGYFRVSRRLLRLTTTRILDQGFAIDLVSLTKPPLHQSPIFCFTGVDPEQRSEMASRYGSRVFDPLWGGDEKESPECSRTTIWWEPFWMSISFWDRQMDLPFREDRFVARAKMHEIEMLGLLDHDVLSSIELPFLPDLYDPFATPNPNSRNYGEGTNKIMADKFDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLB2</accession>
    <name>A0A2R6NLB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001104">
        <property type="protein sequence ID" value="PSR73144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLB2"/>
    <dbReference type="STRING" id="98765.A0A2R6NLB2"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="12149" checksum="CB299EBFA27EFC85" modified="2018-06-20" version="1">MALTIWGTRAGGGPYAALAALTNIPATILGALFYEFILMDSSRGKLWSSLSHYLNVDHLTPCLSVITSSHAEFLAGHLAHAEHKEQSSSARMGSGSPSTYTSDDKAQIEAIERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLF1</accession>
    <name>A0A2R6NLF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLF1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7341" checksum="27F131A2CA09A0C3" modified="2018-06-20" version="1">MRERQLVYRKKYLDSSHVRARGRRVLEGMVGVGTLGSLVTAAFRMRARMSEEVRSWSGKLKGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLM3</accession>
    <name>A0A2R6NLM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1682-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLM3"/>
    <dbReference type="STRING" id="98765.A0A2R6NLM3"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="44249" checksum="A65255D234282B72" modified="2018-06-20" version="1">MNSPLAPLTKILAAISPPPIVITPDYDGLEFKWKFFTFRPALFRNELYFVTAVIVYLVFYSIGKKANYNRAYKWVESHMPIYEAQFSAPVQAGGLTRDGNSDFFVFSTGRRAISSLHTVLTLRPRHDLFQLVYQFIRGIIELDWKVVDEVELDFTFQEDSNVPECIWAVVSKDELRGIRDRRWDLSFTRTTDHPSLPPSLTVMSEFADVTENMFKQHGPFSLSSVLSSPELLPYFRSLSLTDQPRTRPLAPLPASQRTKHLTLSLALPRSAAASTTLPIVDAAFKLVDIVTGTGGWGVGKGPGGKPGVGLNPSLKPETRTKLRVTREKLGKELKEEAVKEQREEAEEKKVAAKKKAEEERLSKLSAAEQKKQLERDRKRMLRKTQGKVAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLM9</accession>
    <name>A0A2R6NLM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001088">
        <property type="protein sequence ID" value="PSR73282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLM9"/>
    <dbReference type="STRING" id="98765.A0A2R6NLM9"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="248" mass="27367" checksum="3ABC360500D11A57" modified="2018-06-20" version="1">MEKKVAEGLPEFSKYAEPVWTGTIAYRVLVPVDRLPSFVLEKPALKKPLLHVVTYCIAQGTMLNVVALVSQPELSDTVYDGPWATECNPAEMVDSFLDWEPRVREVLKLAEKPIKWAIHDLRPLPIYVSDNVALVGDSAHAMTPHQGSGAGQAIEDAYILGSLLGHPSTTLDTLPHALKAYEHVRLPLANNVLTCSRDAGLIYDFRSECGDDYEAIGATLSHAWDWMGEDGVEEQLQKALSNMMEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMN8</accession>
    <name>A0A2R6NMN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMN8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7814" checksum="607F254DC15C82E9" modified="2018-06-20" version="1">MTQNEPEARPDAVAAEKMWREISARLYKLQRGWRLRGRKELWAEKVVFDSFSAVKQIFGWMTDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN58</accession>
    <name>A0A2R6NN58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001061">
        <property type="protein sequence ID" value="PSR73828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN58"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="928" mass="104907" checksum="57CE9B6841FBF0DD" modified="2018-06-20" version="1" fragment="single">MQRPLYDVHRLPCPSCRRVFRNTSGLTQHYNTFHSRPHGHVLPAPLVLQPTPRRAESVPPNQPHHIIAPPDDPGALNTLNPEGLYYEFHSELDGRPCDSMGVLLPDANVKPPPRARLETDWSPYDTRLEFETAEFLFQRVKMGQANVDLLLELWAASLVPYGGRPPFASVQDMLQVIDSTAIGDAPWTTTTAKYMGRLPPNPPSWMVGSYEISHRNPLVCARNMLMNPDFSDEFDVAPYREYDGLLKRQYTNLMSGDWAWKQADLIAVDPETHGAMFCPLILGSDKTTVSVATGQNDYYPLYMSLGNVWNNVRRAHRNAVVVIAFLAIPKTEKRYAKDPVFRKFRRQLFHSSLATILNPLKCFMEKPDVVRCPDGHFRRAIYGLGPYIADYIEQVLATNTVQGWCVTCPTPRESLGEQYEGPDLRSREHTELLVDGFDLKTLWDDYGVVGELIPFTNDFPRADIYQLMSGDLLHQVIKGCFKDHLVEWVNEYLKLTHGQTRGNEIIDQIDRRIAAAPAFAGLRRFKQGRDFKQWTGDDSKALMKVYLPAVVSFVPPDMARALSTFMEFCYLVRRSVQTEDTVAQIKDCLQRYHRLREIFRTSGTRPDGFASFIRHHSIDHYPGHITNYGAPNGLCSSITESKHIKAVKEPWRRSSKHNALDQMLRTNCRVDKIAASHVDFTARGMLEGTCLSEAVHSFVLTEDSDDGDGELEEGLADDKPGSEDEQEDDAVDGARVLGDVSLAKQYQRYYPTTIHRLSKHIRVRRFKQLVSQFIYDQTHVDPLPDDSPTPPLPTLHGPIRVFHSAAATFYAPSDLSGIGGMRREHIRATPRWRKGLPRYDCVFAEKDSSLEGFCGLHAARVILLFSFTCAGVKYPCALVRWFSPVADKPDDLTGMWVVEPDVNADGSPSFGVMHLDAVLRAAHLIPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNA6</accession>
    <name>A0A2R6NNA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001053">
        <property type="protein sequence ID" value="PSR73866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNA6"/>
    <dbReference type="STRING" id="98765.A0A2R6NNA6"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="309"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="678" mass="75657" checksum="DEED46F8968DC3C8" modified="2018-06-20" version="1">MAVTLARLGRFLRSIFAPATAIISFSCILTFIFVLYQPHAGPGALQRLGWQSWDSISDIGPGVGSTGSQAPQDETEVGDIEVPSSGDFPEGVDWWNVAAPDNGVSVDPTSLPLDIWDPLMPHDTGLTEIDIKQCLIDSYFIPSVGTLCGPSTTKEQDSLKGKWVQVDRNLNFQGYSFVNVYYRRTRRLDIPLITDIRILPEKETPSPFSSQWSKVSRPVSPRGETLYLWYYKNKTLSEMSNAEKQNNLITEIDVTYGDSDAWYGFEKLERPVASKDEGKKLESVWLTTRKGVKPPPRAGPLHFSHDGKFKIMQIADLHFSVNQGVCRETTITPCAAADDMSISLLADTLDKEKPDLVVFSGDQLNGQGTSWDAKSVLAKFARAVTDRQIPWAAIFGNHDDEDGDTRAEQIKYMQGLPYSLVQAGPKDIHGVGNYLHKVYSADPSKTHILTLYFLDSGAYGDGKWDFFNIFTPTEYDWIHQDQIDWFLEESSRISPIVRPFTPDGSQDLGSIWNRDDQFTPQTRLAKPNALMFFHIPLEEAYSMADKDPKSGAFLDLGLHDLEGHGNSKRQDGFFQKGLLKAMESDHSSGNNAREVKVVANGHCHVTENCRRVKGIWNCFGGGGSYSGYGKIGFDRRFRIFDISDFGETIRTYKHTEHMPALNPQILSGHGAAPPYEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNI3</accession>
    <name>A0A2R6NNI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001037">
        <property type="protein sequence ID" value="PSR73985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNI3"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="248" mass="27384" checksum="75EE72FD7084A05A" modified="2018-06-20" version="1">MRKFMHVNTASRHLFTVKAAVVPIAGITFFIWCIVKAHGVGPIIHQPSQVHGNVLGWNMVASLMSCISNMATLVTNAPDFASRAQHPSAAVLPQLISVPLGFSIVSFIGIIVSSSSQTLYGEAIWSPIDLLGTFLDNGPSHATRFGVWFISAAFIIAQNIRRGGYIAAIVGICMLPWNLLKSSNNFSSYLSAYSVFLSSIAGVMISDYYLIRRGHYRLTDLYTTDKQGWYWYTYGINFRSVFSVVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNT1</accession>
    <name>A0A2R6NNT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNT1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8049" checksum="C0495ED6128BE654" modified="2018-06-20" version="1">MRIQAHTEHDISGTDEDDIEVIAKATTSCSDPIESSSAPCGEISGKSSWGASKRTTSTKRLDTQLVHGYEPRGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNW8</accession>
    <name>A0A2R6NNW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNW8"/>
    <dbReference type="STRING" id="98765.A0A2R6NNW8"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="479"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="769" mass="87126" checksum="3B327264054ECA7A" modified="2018-06-20" version="1">MVEIKSEHLEDSVQSSPSVGVDNHEGSKYRLLYSKSKVYVNPTAYSRDNIPGFVALVKRVGGFSVCLIAANASLQEAVNPSYLLAWLPETLLNEKGQTEWDKFVKIEERTTLDEEDDVVLIDMPFPRPETYAFSVALTSIYSLVIQPPSLSSWHGTIAINIINGTTLPTLHFHDDESRSFTLLQKAPVDPKHSSYPPPQSPNASTSKTGVTWGGEDLLTRLKTYAHIMRSNLQPTLFLIDPSREDIETHSTQIFSDDAVDDILAQSSYANSHSPIPSHRRPRPLTSTPNPYSPRSSILHRSLNSPSPSSSSTSQARLALLQSFSQITRHAAHAAQQILSHPLAKPIIPHLPDPVRSLVNVNGDLEWGSWVEKGGVGEFESARVYLARWARIVAEEGERSRRREAQALPTSSSTELPAENSSLGVFELLHSTSNLPTPKSSRDPSNPIDEKAWKKWFNADGTPKVRIEEMRREIFRRGISPTGTLRKKIWPFLLGVYEWDVDERKRLELWEAKRKHYRDLKDQWWGVPEVFERQDVIEERHRIDVDCRRTDRTQPLFASSTPSIDASEDEKGMHMRYSTISPGLGDIGAQAPTNEHIERLATILLTYNFYETELANQPLTSRRWILIAFKREFAFEDVLRLWEVLWTDYYSNAFVLFVALAVLESHRDVVMRYLVEFDEILKYCNELSMTIELDTTLSQAEVLFLSFAQVVADIDRRQAEESVATPGDLRRRNPVAGDKSPQTARSQSKQATFKTPVLSEEIRDLLKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP35</accession>
    <name>A0A2R6NP35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001013">
        <property type="protein sequence ID" value="PSR74200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP35"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10028" checksum="0BF5BEE7829BFA5B" modified="2018-06-20" version="1">MLVYKFGAGLLMNTMWNVDYLGRQCSNDLAAVVEGVAKGLGHDEEQCAERGMALHEGGTAALLEAVMNGVNPGIRSLSRFGRVIMENVVFIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP44</accession>
    <name>A0A2R6NP44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001011">
        <property type="protein sequence ID" value="PSR74210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP44"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6901" checksum="66239504E3972677" modified="2018-06-20" version="1">MTSLGKALIHYSIHGLSPAEAKAWYAVMKDIVNVYRKKLRTRGAHIKEGALTTLHRLELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPV6</accession>
    <name>A0A2R6NPV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NPV6"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="1236"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="812"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1168"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="866"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1603" mass="176196" checksum="8DB82334D1C1FC62" modified="2018-06-20" version="1">MEKPLPDVPHPSAGAGNLKSPRGPGTKRATQISTNTTTLTIDARDHLHQFILAALEGEGEEKEGTSAGNSESERLEWAVGLETALGALGERISLGGWLPGLRRARSRRRQEKELARAKERASSKRMESTDTVTPSRKEEGTMKSKGTLHHPHFDPKDELGYLSAGLKDGEKAEEGRRVSVQLLRDLASRPSVATPKPTAKHLLLTVTPYGAPVPPPPEDMGYEFVRSNLECVFTAGVFFLPQDETAQSDAHGAVLYGLDSWDSGSSAGSDTLQIVGGTFSFRGVLSEAQHAALTKVLRLSIYVYLSNILEQSLLSNSHVPLRFPKPSMSPTTQAGPMSRALSTSHVGSKHHKRDSQSGLWAFFSRKKETLLQRSSTPGVVRRGSLELPLTRKLTRDRSPVPRISDDSTSPRPRRFEFLGDYRPAFMLSSKGPEPEERPFSAALAQIQKYKGLLSASPHVTYSPPSLLVHLAQRERSDPGRRLCGDEKAALTSLLGWEGKNGMGMSDTAGFVRQQSFSALYSEYVPQPAISRPATPGSSQSSFGSLQPSQPNNNSVLCGRRRRWVTFRFFSREGGTDECLGETILKLCARADEPCDEPGCSFRRGEHELRFVHGTVRITVKVRPASSLDAEKEGEGDLPQMSVSCKVCAKQSPKDQMLDGTYLFSFAKFLELLVYSPTLSHVTPPLCAHTTLPPRPRPASDSPLPHTRMNLVRDFTFNKWTVSFVLSPVGDIYEVRVPRFQILRSKGQDKPEDTERLPPVASVSIETDRRALRREIMQFWQVLSEHMDQLEGNFMNEHPVSFHKSLPRLPSADDAYETFDDDDLLTPKGEPSKLPPHPPNTPRTPGTVSSNNSYPFPNKSASRDLSSTESQSSSSLSTSGLSQNSDQGSLHRLSNLRHTFQRTEQGLYTELSRTPVSNLNDVRRSFFSAAHGATRRLSAWEAKHAAGSPTASEAVAQCEPEWWKSGCHAVPGGNVIVREDDWGSIIAFTLSSMDYHKELGNMSTNRSTVVPAVPPPTPAVSRPSFFVKTASAKWFGPTIPMPDPDQDGVVWHEPETYSAVISRKEHPRDPTSLLKLGIPDVLRQKPIADPAYPNASKLGSLGSASGKGIPVVPPPSAWAKPDVQISTQAAGGLLSAAAVDRVDKVLHDLEAAEPAKTIRRVPSDTHLSSGFVETNIRRGKASSIMSTNSDVTTVGEHSTSTHSITPPIPPPKDESESHQESSSSIGDPPIEHSQSPLPALAAAAFTNTLSSAFRYMMRTGEAPPIPAKHHHGLLSASCSAIDDKPHIKYDWTIGKRLKFSCTVYYAKQFDALRRRCGTEDIFLQSLSRSENWIAEGGKSKSNFWKTADNQFIIKTLVNAWNVADLHVLIELGPSYFRYMDATASKPTVLAKLLGFYTVEIKNLETGTIQAKADLLVMENLFYKQNIVKTFDLKGIQGRKVKAASSSSGSKTLFDGDWIEGQQRALTLVQPHSKVVLQEAIRADSEFLAKSNIMDYSLLVGIDEDNKQIACGLVDTIGSYTFAKTLEYKAKQGLNSGKEVTVVPPNEYQERFINAMDDYFVACPGKVDDEICRLKCFTHFSPDKWSRPLDDTKIPGDYRQLPSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ55</accession>
    <name>A0A2R6NQ55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000968">
        <property type="protein sequence ID" value="PSR74674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ55"/>
    <dbReference type="OrthoDB" id="2534923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="882" mass="97783" checksum="6E7CEBA28B42D3E5" modified="2018-06-20" version="1">MDSKSCRIQRGKPNSWKRRDGAPKTKMREAEIVETVKETQAGRKGMLGSSFQRPPAEQVFMDPGPSRGVLYKALNEFRIQPFVNVAQSREQDVAKLFKKSRGQWWSMWKESERWYQPKVEAISPQNASLPLYTTMTSTAYLVADPSSSTYSRQIPSSPLSNRSGLPGSSAAGYTPFKAPAHKHAHHLHSIPPREKSTRTLIIDHLLWVHARTRFAQARAELGMADRTGGTHSPNYIHRERPENYEEEEDVYSEGEDIHSLTARSGGPGHTHEEDEDERLDMQDLALARSLRQRAESVEKVITSMLDQPPAVPPVLPEELLEPPTSPQLHPHNPHQSSRSSTRQEHMLPNGVRLRLALGTVINDVFARRAPSPPTRHYSSHTSPRPPPSLPPVVTPLLSVSMPRTMPYPRKPLPNDYIKSLYNIGADPDSQNSPPALRCPRHLLMGCEICVEAKVVPRPMGEKKSRGASGRAASTAGSSPGDGASFVSSGNVFGLGGGVTGWQEGSGIGSGLARPGTHGTVLRRPSHPSKADEGFANTKLAELIVRFLRLSALVAIELGREATEDRASIDGERPSSSTGPPTLSPLLTPRMLPHRHLATTELHANALRPTRAWYFLLAGLLTRTVLEGYMTGGWRGIDALEVLLCVGLGLPPKSANVPPRKESGAHDQSGKGKERDTFDQFDPDDLPDLEDAVKILFPSLRDVNPGRGGFPQRRPEGAEQEYEIEMMERLARFYEVPQNTPDVATHMEDLAWQYPAEAVERAGCRFCEAVARWRGKPELETYKKASWIIGNKDSRHGASMSIDALVHSNPTSPARTHTISDNHLSHLPPLPPYQPPNSHISRKPTVDDYFNIPPSMLLQGRKRRRSEAERSDDGRRIQTQMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ71</accession>
    <name>A0A2R6NQ71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v9943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000996">
        <property type="protein sequence ID" value="PSR74326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ71"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ71"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR74326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="347" mass="38032" checksum="EA6D213B5C18138C" modified="2018-06-20" version="1">MNRPPAAAVHTPGFAHYSVAWSPFHPSRLAVASSANFGLVGNGRLHLTSVAPGPGGVPALSLDKHYDTQDGLYDLAWSEVHENQLVTASGDGTIKLWDVMINDLPIRAWHEHTREVFSVDWSNINKDQFISASWDGTVKLWSPERPRSITTLNAHTSCVYQALFSPHQPDIIASCSMDGTLKIFDLRSPILKTGPTNFTNPVSPAALTVPASGTEILTLDWNKYRPFTLASGGVDKTIKVWDCRMVKLGAEASQNPGVGGICESQLAGHEWAVRKVHWSPHRADLIASASYDMSCRVWSTSPAPGGSNLLHIHDPHTEFVVGCAWSLYEERVLASCSWDCRVNVFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQF4</accession>
    <name>A0A2R6NQF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000957">
        <property type="protein sequence ID" value="PSR74767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQF4"/>
    <dbReference type="STRING" id="98765.A0A2R6NQF4"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="44"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="370" mass="42466" checksum="10842F22870C54E9" modified="2018-06-20" version="1">MSVNKLIGKVRLNGKKMRVSGFLLAMIIGQLSFASMAQARNLILTDTVASVGIIPRYFRFVSENNGIRHLRHALALDERRIKFLPSYCVDPRKTKQEIMKKNQIEKDEGYSAAKMYEDQVNAESQESDVLEVWFAGVHTDVGGGSVKNDTPHALSRIPLRWMIRERFKCNTVIIFDAIMLQQIGLNITYGPDSVPILGNIPPRLPPPPPDVSAFENTPLAPMMRHNALRHDVDERYEAEEERKDALSPLYDQLRANWMWTVLEWIPVRVKKQKAIIREIENIQGYTWLWNKGRGRKIYKSEMEEGMKVHRSVKTRLEAGKTFEGSSSSYVPQVRPSISVVGKDGKKTYDPVRLDHTQWNVDTPQHWGWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQP2</accession>
    <name>A0A2R6NQP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000948">
        <property type="protein sequence ID" value="PSR74879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQP2"/>
    <dbReference type="STRING" id="98765.A0A2R6NQP2"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="317" mass="35212" checksum="E48C1BBBCDD106CA" modified="2018-06-20" version="1">MGACLLECQRYGHELGVRTSEGNAKSGGYKIGGVSSFLFTGLHHVAALMKDGFCIWDAKARSTFISRPFFAYGAADGPGMTYLNGAVGHLGAHGCRLYCTQKGRLKPGGSHYYPACLKPHNYNIEGSSHNDVSLREPPSVNYGEQCVARHAESLRKVLGSRNPTVFKRIRLETGLTKPSLFSGLPSARRFPIPLCFPADIMHLVALNIPDLYFALTRGTLACNPKDDKATWDWICFKGDPWKTLGDAVANARTYLPGSFDRPPRNPAKAMNSGYKAIEYLTLFYGLGPAMFRPLQQEKYWQNYCKLVRAVQLLHQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR34</accession>
    <name>A0A2R6NR34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000933">
        <property type="protein sequence ID" value="PSR75081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR34"/>
    <dbReference type="STRING" id="98765.A0A2R6NR34"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="291" mass="31710" checksum="E0342B1CCCE4587E" modified="2018-06-20" version="1" fragment="single">LGPYEQTAQVCASFVTHLFAGPELPLMSTSRMPPLHLFIAYALCRTKLDVSVTFAALLFLRRLKTRFPAARGLSGHRLFLSALMVASKVICDDTYSNQSWSIVGKGLFSLAEINRMEREMCSDLDWRLNIEPNQLREFEAKVRLDFKGLGPYPNYAVPSPAPSPMHSTFPYGVGLTSTAPSFTRHGPSASPPKSAPRHPSAPRHPSLNPILIPKCAYPSPTSSPEVPDTPEASHSASTSPASTTSPRTPRCDEDYTAHIVLSDGPSLLSGHGCFGQAMFNLHGKQYPVFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRI1</accession>
    <name>A0A2R6NRI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRI1"/>
    <dbReference type="STRING" id="98765.A0A2R6NRI1"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39060" checksum="5793EAFDF3F053EC" modified="2018-06-20" version="1">MVAGSYSPVHEASLIDPSLHSPALLELLEVKLSRSLIEYVVDCVAETVDFAMGRPSTSSRGRPQSRQSDHSNFTNFVTNVLHKAEVKVPVLLVTLVYIDRAKPHLQIALEQWACERVFLGALIAANKNVHWALCTGVFGKRDVGRIEREFLDVLDYELSIHESDLLSHHDAVISLSHPSHHVRHHSRAHAAVSAPASPHHHHHHHKSLVKTTPPSRWSSSSESGDSDADSVSSTPLQTPEMQVDPSFVQPALAKHTPEESYHSSHPMVLSPAHVTHSKPSTTDIHASHPRIYSSALQILRSFPMPHFHSGSSTSSTPSPPGSSTTSSSASSALSIPRSKSMAHHHLMPPTRPAQVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSC0</accession>
    <name>A0A2R6NSC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSC0"/>
    <dbReference type="STRING" id="98765.A0A2R6NSC0"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="392" mass="44092" checksum="7CBBC3E8000C75F8" modified="2018-06-20" version="1">MSNNNLADIWASPPLPPTGLGRHRQLAPLAGIHVSPIQLGAMSIGDKWHPWGMGSMDKESSFKLLDAYYEAVSSLLTNDAWELSFCSQDETSELFIGEWMELRGVREQMVIATKYSSNYKRGEKISQKTQFVGNSLKSMHNSIEASLKKLRTDCIDIFYVHFWDYTTSVEEMMNGLHNLVVQGKVLYLGVSDTPAWIVAKANTYAKENSKTPFVIYQGPWSILERDVEREVLPMVISEGMAFAPWNVLAAGKIRTDAEEQKRRETGEMGRTLWGDWERNEQERKVCAALEKVAEELGAKSITSVAIAYLMQKSPYVFPVIGGRKVEHLRANLEALDISLAPEQIAFLESQVPFRKGFPYDMFGDGTTYSLIGNSAGHFDKWPVQQAIRPAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSN6</accession>
    <name>A0A2R6NSN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v8854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSN6"/>
    <dbReference type="STRING" id="98765.A0A2R6NSN6"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR75940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="263" mass="29927" checksum="22549421077E79F4" modified="2018-06-20" version="1">MAQLRTPFSPTPCDIADGATAPAIVTRDGSYTWVPLIRCIAGFPVELFESAVAQLIHHPEYNSTLILRSETIFETTEEPDIPSSIPALHGLRPTRVVHRKLLPRRPGRDTSLEQYCTLFTASADADGIPSVLLLTPIVTPESPLPYYHPRVSHLAFRILAGDPPMLQIEVVPLPDTPLDMGSRLYRTCLSLLETLHRYGWGAMVNYKKRVVHDCIVPREVYQDLYLVMRERHKHIVNEWKEVTDPLKHVFEVCHICFYRIVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSW9</accession>
    <name>A0A2R6NSW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v8738</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
            <location evidence="2 12">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000868">
        <property type="protein sequence ID" value="PSR75997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSW9"/>
    <dbReference type="STRING" id="98765.A0A2R6NSW9"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0243">Dynein</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR75997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="13729" checksum="4C58DC2EFA3F792A" modified="2018-06-20" version="1">MSEKLDAPTSSSTDTSSSPNGAGGPKAVIKNVDMSEDMQQEAVDVASAALEKYNIEKDIAAQIKKEFDRRHGPTWHVVVGKNFGSYVTHGQSHMSQLWSTTALVRRRDETRLTTLLSFALGLTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT60</accession>
    <name>A0A2R6NT60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8608</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT60"/>
    <dbReference type="STRING" id="98765.A0A2R6NT60"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="26099" checksum="0F2E3C8D050B8FFD" modified="2018-06-20" version="1">MSLDSTLIVHHLNDSRSQRILWLLEELEVPYEIKKYQRNADMTAPKELVDVNPLGTAPVITDRGVTLAESGAIVEYIIDKYGGSKALPPDSGKVDNLFFTHYAEGSLMPLLVNKLIFSMIPDRAPFILRPILRGVFNSLDSALINPRLKTQADYIEKHLSKCGDWFAGGQGPTSADYMMSFALEAWANRSLDMLGPKSVEYVKRIQARRWRKAVNTNMQNPLFEPLDLEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT75</accession>
    <name>A0A2R6NT75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT75"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="12036" checksum="F64C7078BE30B1EA" modified="2018-06-20" version="1">MVGLSLPKSQHEAAEALYRSLPNLIAEIGQILLVNRIELELWSRIHKYPRIETTAPKHDAGLDMGILVQDFLYHPETLETPPRLSNQDERTKWSWIRLTNGYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTF5</accession>
    <name>A0A2R6NTF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000850">
        <property type="protein sequence ID" value="PSR76315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTF5"/>
    <dbReference type="STRING" id="98765.A0A2R6NTF5"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="255"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR76315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="398" mass="42898" checksum="D7383B337B94FF9A" modified="2018-06-20" version="1">MTENLNLQRGLLRHISQFTEVELLDKIKVQSIATEDREGGGWPLVHLSDGRTLRARLLVGADGFNSPVRSYARIQSYGWAYDRHAIVATMNHPPRGPFQGSNTVAYQRFLPTGPIAFLPLSETSSSLVWSTKPQLASALKTVDPQVLADMINAAFRLPDVSLCYLQDRILDAEQSGSPLKPSQFRDELAFRERSDTIDVRSAYSSLAPEQSSAGIPSEDADAVPPIVTSIQAGTIASFPLRFSHAESYIGEGQGVRTVLVGDAAHTVHPLAGQGLNGGLADVEALVRCIEHALLRGGDVACDKLHKLYSSTSQPVVWARSVGLEVLNELDTIKAALMMSAGSERHRRRPGEVGWELAAKSIENFATGLDNARALGGSLANVVGDGVRSLWERGGSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUM1</accession>
    <name>A0A2R6NUM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000816">
        <property type="protein sequence ID" value="PSR77045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUM1"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015304176" evidence="2">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="109" mass="11704" checksum="A60B6CDC5CA9F3CF" modified="2018-06-20" version="1">MTLSVCSLIGVVLIARPEFIFGAASHEVDIPIIDGTGHIAEDANIAMEVTKEDTGARKRAESLVNSAEDLSLEEGLLENQEEDPTKDSDPLDMTIKVQNGHADLDKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUT3</accession>
    <name>A0A2R6NUT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000812">
        <property type="protein sequence ID" value="PSR77142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUT3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="230" mass="25434" checksum="A4A347E58D86DE70" modified="2018-06-20" version="1">MAVQDDIIQLASTTSNNFDRFAEAVDRVNIDIDSLDEKIDNLADNLVATRGDVAETKDKVTVIEGKLTGIENQLVTVDGRLYPIERSIGTIELRLINLEVDVAEIKTDVAELKTDVAEIKTDVAAIMELLKERNSRRSSRASSRHSASRKSSVSPNLKSTFIFHSPPHEAGPSQVNLSVPELLEEGLRRNQDSRKAHDEETKIWGTLARKLSNSRSPLPLAPTNNVTLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUV1</accession>
    <name>A0A2R6NUV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TEL2-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUV1"/>
    <dbReference type="STRING" id="98765.A0A2R6NUV1"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="3">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="3">
        <location>
            <begin position="147"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="4">
        <location>
            <begin position="775"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR76730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120006" checksum="FCF0BBCEF7ABBFA1" modified="2018-06-20" version="1">MSRAETTQDAFKKLIQTLHEVSSASGPFPVSLISYVFFPISTILRRNPSSAIPDQILEKILVILGILCDTWWWDMDTQTWEQIFMLCSAILGGIEAKDRGKNRDDETQYAAVQCLWTLVHPRDPSEDSAGPFNSALRFSTKYAAFQSHAQTPTFIPIMGQTVNSLLASAESRHTPLQKVSLQMLQIVVKDYLPDGFVPSVLPGIISCMSKIALGTGLSKGWANGDTVAAALTVMKEAIIRAIGDDICAMEGAVRRVTDLEGLAESESNSPKPTTTSTSPYSTARTPVWLHGTSSQLHIALNSLSPLLSHPTPSALLALVSFSHTILLATTLTVPQSQPLLLSFLLSLSSSDYDTVAEQSRSFLLELLSPSSTSCHTFLPVLLQISKDNLAALPRLLPSHSDSKVEHAAKVVQAVCMLANGLQAIASGVSILLGPNGGIERWGWSLLSTLELDSPTSPISMASTAQLMLENDSEGQQWVSFPLVTLHHLTSQSAQAAVEGMFQSLGKAAGDDCLFAVDWFLGISERSRGSRAVSALWCACRLLEGVAGVSLNSPVTPHVAARRNKLEKFARGLVRSISEFWDEDTVDPVESTTRETTHDADSMLVEHVKGLTTVRTPGGLEQSLSFRTAHTNASEIQPILHTVFRLQALAISSAILQSRFTPLLLNTVYPILHSLVAKATYLSTTALATLQYIAHATSYASPANLLLSNFDYALDAVSRRLSRRWLDADAATVLLILVRLVGQEVVQKAGDVVEECFDRLDEFHGYEVLVDGLVAVLAEVVAVVGQETHKPTEPNPSLFTSPTDPQRFDSFFPWFSGRNNSHATDDEETDFGPVPQKAWGSGAGDEEGETAAGQAADPVAEPPPTPTQLLTKQIISRSLFFLTHGSATIRARILILLSSSVPVLPDSALLQSIHHAWPFILNRLSDPESFVVASAATLIESLAIHVGDFMYRRIWDDIWPRFRTMLNKLDAADATSALARRGPAVVGTESAYTNSHRLYKAILKTMTAAVDGVQPHDPASWEVILAFRRMLHNQAHIELQVCARELYAALGNKNEDAVWLALTATEGKIDKWPFPYEPKWDIEENVGLILGRFCGSTTTGNGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV42</accession>
    <name>A0A2R6NV42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000796">
        <property type="protein sequence ID" value="PSR77379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NV42"/>
    <dbReference type="OrthoDB" id="10007484at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="4">
        <location>
            <begin position="217"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR77379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1869" mass="209767" checksum="12BE747531AFB080" modified="2018-06-20" version="1">MSQQGITPITADELQNFTVPEIRQLVGPRLLVPRSHSTPKSVLLDWIVAHADDELCRHLHLACAEKQTEMHRQSLARKRKRKETQSRQRQAARLEAVESHHTHDIDKYLDLPSDATLHQCSIEYIQATSDSSVQLSVCAICAREVAVKDDNVINIPLRDIPHQPRLFPHRAHAEHDLYDGMLLEPSGVQVQATGDEEDGPRANVCGSCHDQLSKDGTPVLSLANGLWIGRVPWELSVLTVPEQMLIAHLYPRVYVFKLFPRLVNFRPHIDSLQSAMRGNVSTYAQDLPGVASMLEGQMMPRPLEILSSVITITFIGKGQPQKEWFKSLFRVRREVVHNTLRCLKQINPHYAEMEISLDRLNSLPNDDIPAEIAELIRHNEDAGVVDEEAAGYVPEHPENIPAESAADFHTGSAASNDNQSAQNLDIPDVIPLQVSGSIDTDLTKLTSSELMLWGLSNLWDDGREGGYSIRHGSRPVPDLPPRRPSTLDNSSTSDNPAQNFFEHAFPCLFPYGCGGLEAPRTKHIDFRTHVQWCLQYHDRRFRKHITFPFLCFGIIQKRDALNSAHVQMLRADFERDAHVMTTLSVDKLREAQREEERGLPTSDPAVRLLRKHVHATAGRVVGTDQSRYRMRTLGTVESQGRGTLHLHMLLWLKNTPSGDKLEELLKSEDFRAKMRTFINANIRAYLPGLESAASVKAIPTDSEVSYSRPLNPASPTYSEDAAAFELKLARSLQVHTCKVRRCLVPDKQGRLKCKRKAPWEIAAEAFVTETGRWGPKRLNAFVNGYCPPIIRNLRCNNDCKILTNGVETKNITFYVTGYAAKKQGRNFNTSAILAEGFAYHVQHPNADYMDQLRHNQRLMLFRLIQAINCEQELSACMVMSYLMGWGDVYRSHQYTSVYWSSFVSSLMKAYPDLQRAPKTPNDAAINTGSLASSEVAAEPNDQPNDAALEAHADEFITLDTNSGGRIYARSQVTDYALRGNELERYSVYEFFLNTYETPRRKGKEVDRRPEEERTGARDDGDEANEEDDNGHPSSEASISRQRGRTAHLRSPYQADHPNAAQKERMVRTEMHKNMVNFVGKFFPSRSDATVYEFYCASMLMLFKPWRNISVDLKNEDESWSDAFSRFVNDNAGGSGVLKRRLCGIQTFHDGRAAAANDQRDEIGLPIDDVELQGAMHGIDDDDEEAVDGVDGVRVTAEDVEALIQLQVPPRERNHARQAVELAKNARIFADRASQWTATDHSVTMALGGDVVQLAQWQAQMDRDVILQNTLAGNVTPTVSTADSEQPSVEPIMRNNVDPGPSRDIGAQVEPSSPITAAGTLCAATPSMLKDDQFRAFDIVRWHLVQNLAGKKPPPLRMILYGEGGTGKSKVIQTITEDFDQRGVKSMLVKAAYTGVAASVIDGKTTHNIGGLSVKKRGDTVSDDSKAKLQQFWKNKQYLIIDKVSMISKSFLIDLERNISIGMQGAEAFQADYSFGGLNVLLCGDFHQFTPVAKGPDEYLFHPADLAEHSEQCVLGRRVYKEFSTVVILNQQMRVTDPVWRDLLVHLRKGEVKRAHIDCLRTLVISKSSAAVDFGVEPWKAVSLVTPRHAVRNMWNEHAARKWCAESGQQLFVCNAEDRIRKGGERVSELLSLGEQYALAMRGKSANRRRGQDLPRRVELAKGMKVLVTTNLETDLDLTNGARGEIIDIVLDPDEPAIGTDSIIHLKHLPLYVLVKMSRTRASHLPGLDEGVLPVQPMTSTMRIKLNAKTKKGKPAQRTVHRRQYPITPAYAFTDYRAQGQTLPYVLVDIASPPTGGLNLFNLYVALSRSSGRETIRLLRDFDEEVFTKAHDVELTVEDERLQELDVVTKRWWQVIDGELRMKETREVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVY2</accession>
    <name>A0A2R6NVY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000768">
        <property type="protein sequence ID" value="PSR77915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVY2"/>
    <dbReference type="STRING" id="98765.A0A2R6NVY2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="7">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR77915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11368" checksum="277A19DC872F3628" modified="2018-06-20" version="1">MDPSIIPDPSKHHITIAAVYMRPFSRGNVHLASTDPLALPRIDPNYLAIQDFGSTSMLPLNQGGVVDPNLKVYGTSNVYIADASIIPLEIVTHTMATVYANAHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVZ0</accession>
    <name>A0A2R6NVZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000767">
        <property type="protein sequence ID" value="PSR77941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVZ0"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="13054" checksum="E447259E62007D9A" modified="2018-06-20" version="1">MSESTPTKYLFAVFAPDYTDSEGLTRRLAVRTKHLENAKGLFATGVLKIGGALVSPETYDKAEKKLVGSMMVCEAENLDIVRNIIESDIYYTTGVWDKEKLVILPWLSASPLPQTVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWW4</accession>
    <name>A0A2R6NWW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWW4"/>
    <dbReference type="STRING" id="98765.A0A2R6NWW4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR78636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="309" mass="33000" checksum="5934B83E17D07408" modified="2018-06-20" version="1">MPWDTLKLSDGTEIPSIAYGTGSLGKGQGTVDKVDQAISVGFNHIDTAQSYRNEEEAGAALRESGLKREDVYITTKYSGVGGLDIATSIQNSLKNLGVKYVDLYLIHNPRIVPDIPTAWKAMEKVKADGLAKNIGVSNFTVPQLTILLASAKVKPAANQIRFHPYVLAEQTPVLEFASENGIVIEAYSPLTPLTRQPGGPVDAPVKKIADRLKAAPEQVLLAWAKAKGTVVVTTSSNKQRLESYLDAGDLELTSDDIAAIDAAGISGAKYVAIRTFIRRAATAVLIGAVSLSLSKYLGADLPSTMFPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX23</accession>
    <name>A0A2R6NX23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000716">
        <property type="protein sequence ID" value="PSR78909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX23"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR78909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="17755" checksum="32EC91D91AAC9BF4" modified="2018-06-20" version="1">MPVAGPPWMTTASEVATMTFAREVLNVPAPRVLAWSSDAASNAVGSAYIIMEKIDGQILLDRWPLVTDGGDAATMLFEFAGIEKKFQRVPFSQIGSLYFKEDVSPELQDRPLFHAAACDLDDIFQAAAKRYRVGPISNRQWWRGERASMRLDRGPCKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXG2</accession>
    <name>A0A2R6NXG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXG2"/>
    <dbReference type="STRING" id="98765.A0A2R6NXG2"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF25">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="37"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="391"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="426" mass="47364" checksum="7696C5E72C055983" modified="2018-06-20" version="1">MPGISITSPKVYLSQEAGELVLRQGLNPNRMKYADTRVLIIGGGVTGLTPVKNAWTLLDAGYSVTVVSDRWASLEDRITSQIAGALWEWPPAVCGRHTDLVSLRLSKSWCMTSYRVFDKLQKLYPAGGRDGHGIRMRVANFFFDKPIEENAEEYEKMMEIEAAHIRGFKRDPLLAKKHAVSRTAGVVDAYKHESPVVDTDAYMMWLRSLVVSKGARLVTDRISGDLIYMEDELMEMYDAQVIINATGLGGYELAADKTVYPLRGALIRVVNDGTRFPLVTEALVVAHDYEKRDDDGGIVFIVPRNDRTLILGGIAQPYEHQLDLTLDSPEIRRMRERCNKFVPGLADAEYDIDPLVQGLRPVRGENVRVERELRRKQDGSLSRVVHSYGQGGSGFTLSFGCAGDVLNLVKEVEACVPPTPLKSGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYA2</accession>
    <name>A0A2R6NYA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYA2"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10817" checksum="1A85CFFFA98DF3DF" modified="2018-06-20" version="1">MFMTTTTYFISATIWSEQEFVESTVNPGIFASLTSGRLAILKDTAICVNMWLADSLIVYRLFIIWDRNFYIIIFPVMTYIGSIVHGPGLVLVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYK7</accession>
    <name>A0A2R6NYK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000653">
        <property type="protein sequence ID" value="PSR80459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYK7"/>
    <dbReference type="STRING" id="98765.A0A2R6NYK7"/>
    <dbReference type="OrthoDB" id="3262357at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="163" mass="17601" checksum="22629589FD2D4081" modified="2018-06-20" version="1">MSSPVTVGIAKSQFFNRIIDKLTNSTKAVVRLNLLRILRTVCDVHPNRAMLVERFGIYDIVRRLSKHDGAVLVRELAREIMPTLAPALKPLSSRAGKGPDTPKSAIAPKKKMRRAASESAAAVVPTFTGSQVRQTLRNATGGSGSRLPRQSHSEAPQQAGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYL9</accession>
    <name>A0A2R6NYL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYL9"/>
    <dbReference type="OrthoDB" id="2933464at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10108" checksum="861198F190D6819A" modified="2018-06-20" version="1">MRKKPSQVANLVKGSKNNQGGRLAPARSDKEDAKFQCRVDQGEFRDDGTYAVLVQQNGSPHGDPIAKTIVDPMVDTGDDVLNRLEDRWGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYZ1</accession>
    <name>A0A2R6NYZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000633">
        <property type="protein sequence ID" value="PSR80923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYZ1"/>
    <dbReference type="OrthoDB" id="3256444at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="228" mass="25641" checksum="1AB89ADC9BBB9B35" modified="2018-06-20" version="1" fragment="single">MSSRPRRLIKPSGKVKDPNNVAEREEPHKKQHEASSLTEVPSDELDRLHLDLPCATSTTTTTPSVPDVNDNAESEMIQNPKARHLLVENSDCDESPAAASTDKPFIVHDSDSESSASDSELAEPDSDKPEETHRTKRKKKQQKTKAAKRPRQSKFDEVANDGFLKDIDVQEIPKPTTAKSQDNDHFFGPPELRKGGVYRKWALENDFESKLPNDIKKRKEAHEKALDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ85</accession>
    <name>A0A2R6NZ85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Stealth protein CR3 conserved region 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000653">
        <property type="protein sequence ID" value="PSR80465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ85"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ85"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003976">
        <property type="term" value="F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR1 conserved region 1" evidence="3">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth protein CR3 conserved region 3" evidence="4">
        <location>
            <begin position="320"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR80465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="74983" checksum="0249466D1C1AFC5E" modified="2018-06-20" version="1">MKNSEYIPLAQTPSGSWPQVELEPPPRLSRFRRRAIFGTALVIFLVGFYFVAAELVDDDSEDLDYADDDLNLISEFQAAYLPFEFAHHNASSVNARLTPAQELPDYCRDAYMSAGALCFDPDIEPMDIVWTWVNGSDVLLQEAKLLAESQFAEDDPYRPKTSARQERQYRDNDELRHSMRSALANFRPFTEKFHIVSSDFAMPPTLLNSSFPESWRLGQVPQWLDVSSKDWVDENVELNFIHHADIFQSYNNTTFNSYGIESQFGHLQVYGLVLRYDLGIMVGPNKPPPDEPHGEWRSMGESNVLLSARFGARHRPYVLHEAKGVSLSLLQEITAMWPQSLAKAASHPFRETVSGEGDVSMLFIMVHFVVERWREALLWSWTVGKHGGLGDLWGDVTAQDAWRELGGEWGQAELEVEAGYRDTLENQRVAAYFKLSGHRKPDKTQYRFSSGDGYPYAYAEEHHHDEWPSFTSDTPADRLPICTISYDECFTHEGSAFSAATGMFKHIAFRNPKCGDCVIQALVKASGRLGLEAFLPPADRNLPIIGGEFAADPYEVPHLPLEERWEDAEFNVFSVMGASRETNVRAWTLRLLQRYRFVVETVDNARGALGWIDSYTDASMLCINDDVKEDEEEVTDIFRSWQERRWGKPAYWERRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZE2</accession>
    <name>A0A2R6NZE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000623">
        <property type="protein sequence ID" value="PSR81263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZE2"/>
    <dbReference type="STRING" id="98765.A0A2R6NZE2"/>
    <dbReference type="OrthoDB" id="2986975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11507" checksum="BC0C3D2C93179AA4" modified="2018-06-20" version="1">MILRNSKNGLSDNSKAKLQAFWKYYAYLIIDEISMISKPFFAQLSHNIGIGKQKPGASNCDLSFRGINVVFCGDFHGFPPVAVGLSDALYCKNPFLFLLLHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZL0</accession>
    <name>A0A2R6NZL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000618">
        <property type="protein sequence ID" value="PSR81443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZL0"/>
    <dbReference type="STRING" id="98765.A0A2R6NZL0"/>
    <dbReference type="OrthoDB" id="2796020at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="22892" checksum="858964206955B3E1" modified="2018-06-20" version="1">MENGTWELVDLPEGQKAIKCKWVYTIKADGCYKARLVAKGFSQQYGIDCEETFSPVARWESICFLLAHAALENWEIESLDVKTAFLYGKLDEEIYMEQPEGFMKKKMGAKVCRLRKAIYGLKQASPTWYYKIDQSLTKLGFVCTKSDTGIYVYHQRQGEVIVILYVDNILNIGPELKELTCVKEMLSKEYQMQDFGTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZQ1</accession>
    <name>A0A2R6NZQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-xylanase</fullName>
            <ecNumber evidence="12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v6328</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZQ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NZQ1"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015327418" description="Beta-xylanase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="15">
        <location>
            <begin position="78"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR81562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="350" mass="37490" checksum="8845CFD634FC4289" modified="2018-06-20" version="1">MKFAATFAALAALVPFAIAQSAVWGQCTWWYWLDWSYYLCIWNGMYGAKLTSAPSSVPPSHSSVPTSSAPTSTASAPGSTSTALHARAKAGGKLYFGTATDNPELTNTAYTAILDDNTMFGQLTPANSMKWDAIEPEQGTFTFTQGDAIANLAKTNGQLLREPFNDDGTWRSDVFYNTLGTSYVGIGLNAARAADPNAKLYINEYNVEYPGAKSTALQNLVKSLQAAGTPIDGVGLQSHWIVGELPSLETLVQNMEAFTALGIEVAITELDIRMTLPSTAALLAQQETDYNTVISSCMAVAGCVGVTIWDFTDEYSWVPSTFSGQGAACPWDQNLARKPAYTGIQTAFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P072</accession>
    <name>A0A2R6P072_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR82013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P072"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="429"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="900" mass="102165" checksum="CA991ED41A09AAB2" modified="2018-06-20" version="1">MPKSPRQRSVSPRAEPYPTLRTNVARKLQRTRTLLVMRPECLVESKHEKKTVNPYIQEDVDNARREPLKIWLEAVLGLPPERFSEWVKFIKENDWYKDKKIEKGLINFSKASLEVEMYKPFVDIANRILELGKKELLGAESYPLDDIVVVQNDRRSLKQIPEHQGIGAIRRPDLLAVREGKVQQMRGTKSKKFEWSDILTFFELKLSNKLLFNNFQAWRRNRGLPKLDRRTLLPKVSMKKQTMASTKMTLRPRPPKKGEPEQCHDFGSESDETDNIKSDDPRDGDYKNPGSPKPIRDNEESVKADARLQAGGYALETVSCSYGTRLFTTGVVIEDERISLWYYDAAGIVRTKATLSLFHNFEEFAAILVAFACCEPSQWGSLPPNIIKPPQSDPYPESFPPKNLTGYTFPITLPNSGKKILATLQKPVFTQYSLVGRRTFLYVIKTNSPKLKNPMVAKFSYQVTSRKREQDVIEVARDAGVGHLPEVHMWADYWKMSEGVRAIFHARSGVDPEFEDRVFRCIVYTQYFPLRDLFSKSCELIPTMVYQMLDCLHDLRYKAKILHRDISANNVMWEKQGDEVVFKLIDYDYAGFVDDEGKPASTTASSKHRTGTLPFMAYELIRDMIRRAKPDCKPDYQSVVHMLKHDVESLYYLSGYSMVTMPEVNSEVKRTIYRELVSAWEDGSLGVISAQKGQFLRVDILEDMSLPPQSLSLRPWLIRFCEVFQEAQQKLSTYRKSGSSEPFDLETMGGTLSRDAVVRALKGEENIIFSTRREKVAVPPEASGSGASDVKTVEETINKGEVKEPVPARRAPAKKATTKDTTKDNTKGKEAATKDIIKGKKTATAKIVTPKKMAAAKASQVKDDVSKAKLVVASKVATTQVPTKRGPTTRSMARKALLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P080</accession>
    <name>A0A2R6P080_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="6">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v6177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR82002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6P080"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="11">
        <location>
            <begin position="666"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="12">
        <location>
            <begin position="860"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1239"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1343"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR82002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1374" mass="154814" checksum="8C7597127E3CAEEB" modified="2018-06-20" version="1">MAVDGVAPRAKMNQQRSRRFRTAKEAKEVKEKAESKGEKLPDEKAFDSNCITPGTPFMVRLSEQLRYFVNKKISEDSNWRDITVVLSGHEVPGEGEHKIMEYIRLSRAQPDYDPNVRHCLYGLDADLIMLGLLSHDPHFCLLREEVKFGPASKSKGNKSLESINFYLLHLTLMREYLDLEFHEIEPMLPFQYNLERVIDDFILLAVFVGNDFLPNLPDLHIHENGLEKLFDVYKKALPSLDGYLNENGVINTQRLQVILDEMAEWEKEVFEKEYSDLNWYKGKQAKHVKATEMGRKRQKLVLTTSQKAIFEQVKAFVLEHRSPTSVAHQRKSRLTMPNVFPAADRLFVNKLAEDLHLSLTWDEYDEQDNNLVTWRFPGELEEQVPENGESNVKIEEEGEEEDDAAWEDEEDEESKAAVDRVLGKYEKAKVAEDDKEGDFDARYEISIQEKMAEWKRGYYKGKLEISYDDPQDMHDLVYRYVEGMQWVMHYYYSGVASWSWFYNYHYAPRISDLKGVDQMVFNFDLGKPFRPFEQLMGVLPTASKDHIPQAYQELMYDPNSPILDFYPTEFEQDLNGKKQEWEAIVKIPFIEETRLLKAMGSREHRLTEEEKRRNSFGTSTKFTFNAGEPTTYPSSLPGFFPTLHRCTCHMEPFDLPTLDGLHLVEGLCDGVFLGAEALAGFPSLQTLPHTAALGHHGVNVHGSESRNQSMVVHINNVHEGRKVEDIAHETIGQRVFIGWPFLQEGMVKAVSDGLFKYEKLVMTGGPAKVVSNPHTPQGLGIWKTKAERIENHYSKRCGVVTGEIEVLLHVRPLKGLKRLDTGAFVKDYEGPDKEIEQAAQMAVTDVASEDPRFMEKDAPPLSEEFPESSKLFFLGEHAYGVAAQVSETSKDSLSIVLAFFPSETAENEKFKAVVANRLSNRYYPSFKVANMVGLESMAVAKITSSFMVITSDGQKNNLGLSLKFDAKGLKVIDYSRKDGRHWEFSEKAIDLIHEYKQKYPEVMLSLSQRGDAMPRSADVFPQVEDPDAKVKEVKQWLQSKGIRNFEPVSLFCDQLKKETVEEIEQLADSFTSSKSRDAIKKAIVKNIPRQAVLKPSHAVYRLQNQHFALGDRVTMVQDSGAVPLSVKGVVIGMNAKSMDVVWDVPFLSGTTLGDRCSQYRGSTVEFTSCLNLTHPQFIVSTNPEAPTQQQPRSPFKPRFGPRPEIHPASGEQAASGFRPARIQGAPVHIMTNPDRGRGGHQGPAGYQGRGGYQGRGGYQGRGEHQGRGRYQNGRGGHYNANHPADTNGAPSSPPNANGDRIPNNPSGGKPPHAPRDGPTQILPRGGGPNGPSNPRGFVNGHRGGREIFDRGRGAPRGGPRGRGRGQRGVPPIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0Z7</accession>
    <name>A0A2R6P0Z7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0Z7"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR83036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="64577" checksum="5A205BA5F9BD2E10" modified="2018-06-20" version="1">MSNPLSDTVEENKRISDASFEKVHDLKGETSSVSIGSDEARDAANLKEVEELEDRLANDDADEEEYRVQEAYEVALKNPGLAIFTCIGSQLIGYGFAGLLQDILVKPTKCFWPFTISTANLFQALHYDKQMSSKRTRIFWLVFAVLFCYEIIPEFMFPLLTGVSIFCMADNTNPVFRNIFGGASNNEGLGLLEWCFDWNYISSTSMYSPIWLQVNQDIGIMFTYILMAGLYYGNVWKGLQFPFMSQAIFAEDGSQYNQTALLTDGKFDPTKYAELGPAYFSASNALYLVTGNLSMGALLTHVFLYHWHDIKPVVLAFNPWNKHPLAVHDAHFEKMKAYKQIPRWWYFLVLAVAYAIAQATNYKGNSGMPWWALTVLLIISFFFCVLYGLMAATIGFTQFTTSGTSFFQMITGYIVPGRPVANMYGALYGQHPMTMAIALLQDLKLGQYVKLAPRVTFLMQILGTVVGAILNYIMMLSIIENQRPALLSIAGTRLWSGQNAQSYNSAAVAWGALGPQMFGAKGIYHIVPISLAIGLTLPLPFYLAHRIWPKVGFNNINTSIIMQYSAYLSVGINSSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1W1</accession>
    <name>A0A2R6P1W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000551">
        <property type="protein sequence ID" value="PSR83796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1W1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13568" checksum="1584EDAC19505A33" modified="2018-06-20" version="1">MTEDDAGLSASAALIHVEIAGQYRVSTWSESFLEVYYLPHIQDVVTKVKKRGLLNVLNRDFERLVIDNSTHLNHDSKSQIKEIIRQIAETQGYEIAYTRLSSDDAAIVPEQPKPKTKQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P249</accession>
    <name>A0A2R6P249_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000557">
        <property type="protein sequence ID" value="PSR83530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P249"/>
    <dbReference type="OrthoDB" id="2972750at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="25387" checksum="BC713FC4C9EC172A" modified="2018-06-20" version="1">MTVVQSLHHDTQVLSSSEMKGLILPRGRRSVDIAGGAGNSQPAAGPSVGSPDTGSSGGTGRPSRVSSAVLPAVVAVSISVIVVVFGLWLRATLRRHRSRTMRRQKQVKDDGRPSLVDVHLDGATVQDTNWQKMMPLSSEYYLTTSLPLSRASSLSKLHSEEARDLEAFPDSRRHVHPAALQQDGKTLLRVGVFIVMPSAPHSSQRSGLDRSSCDPLQQELSLGLVEVPWDVDHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P265</accession>
    <name>A0A2R6P265_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6P265"/>
    <dbReference type="OrthoDB" id="2796942at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="1">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1472" mass="166474" checksum="3BF71A6F6DF63C10" modified="2018-06-20" version="1">MASLIQSIRRDQGLDFVSLDPNARATIQHLRRNLENALHNLSENLYSKSTHFIFELLQNADDNSYPQDAIPTLHIELNEQGMAIRCNEEGFGAVNVRAICSIGESTKQNQSGYIGEKGIGFKSVFTVADVVEVRSREYTFKFDKREELGMIAPIWIGTPAEYGFTSFHLTLSPDVNAQLLATHIDDIKPTLLLFLRRLRSIQLRISGRNRVFELRNLTPGFVRLEGTGLPSTEYLIVHYEARMAAEEKRNGISRSEVTIAFPMSTSRKPIIEAQDVHAFLPVQSFGLPFIVQGDFLTASSREGILIDRPWNITLRDAISPAFLRGVERFQQLPDLQFGWLQYIPMNISNGFIQPARSSIIEELKRLPVFLCQDGARRVASSITILPAEYKNSNDAPLIPNNYIKKYYLSSQYDTSRDRAILQELGIIDMSFVEFMDGLKKMDRDGSLQEQNDMDWYSRVCSQLRLLWTRGYPGWLRPRISELQIIPLLANHQWVSSSTGNVFFNYQLGDIPQDLVIHLVGNHVSKDSSHYLLLRDLGVQDADVSNIAQQLLRLHSEPQMDSVHHPFLPSHARFLFRYKHNLTLPDQFPFWVRTTSGYASRATEVYMNHTRHQKPSLVQRLRSSKALFLHGDYEVDIPVTGPWQDFLLNSLKLNISPRIVNNALSPEFKDLLADSDTPTILSFLGQCWYDFGPKLEKSPGCLEQLRSIQVYASDSTYRRLDACFIGRKNLRSFSDLPFLPLEDPENKCWDFLGTLGVTFGVSSILYLNKLVALSEKYPVEVPSEEKELEVHECYQQLEARFEDNDDSGRIRTKFQERPLVYVPSSFASLPMDVANTHGRWLSLASVVWDGPRSMRSKFPLGRKECYPNLKKLFCRQLNVPICTEDILLQEMLLLVSECRDTPMSDDQHRQAHDILYDVNAVISKKPGPGNWVSRFRDVPAFPVQTAEGIKLVKFTDDFYVPDRTRELARLFEADVPILTVPPSDSRGTLSRLLELFSSEQFKDVKHLEANVTRTVETVGERTPDTTCSDKFMERIRYIKQFLLHSTGIALAPRIESFVSKLEDVGIYEVNSINVSYSLGDATHDSVEELAIEADTNRCIVFVCGSCVEERRNMLFARRLAEHLPGVETDSICLILNFLSLDSIEEWLRGKGMAGEPQGTDLGSTSEAAWFTEARDNIPIPRNIGQSTGAPALLSTVKLDLAKLLGEYIPGIRNAAARQSISPTICDLGQLPTAFKNLVIEGVQSFENLSPENASTSSMQDIGMDTNHRNNLFAAGEGGESALTDDRSLDVVRLTIGRSAMRSRTGYNNSSAEQLVNGILGEIFVYLLFEKSLRGFDADNWTSRLRCHMPGLSPFNGSSLADFTYPDRFGDLTAKIFGEVQQDSWKGQWPTYHLEVKTTSGPFQVPFQINKHQMATAASMSIRDSTIPRDIYVLLRVYSIRSVGPSLKIYRDLYRALHDGHLQIVSDVEMAITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2F8</accession>
    <name>A0A2R6P2F8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000538">
        <property type="protein sequence ID" value="PSR84303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2F8"/>
    <dbReference type="STRING" id="98765.A0A2R6P2F8"/>
    <dbReference type="OrthoDB" id="2796942at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR84303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="121" mass="13494" checksum="A1A6314F4E95F8E9" modified="2018-06-20" version="1">MDIIKSIRRDQGLDIQVAEPDAKAAIQHLRRNLENALHNLSEDLYSKSTHFLLEFIQNADDNSYPQGVQPALEIQLLDQNMTIKCNEGGFSDRDVRAICSVGESTKKNQLGYIGIPSLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2Q2</accession>
    <name>A0A2R6P2Q2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000542">
        <property type="protein sequence ID" value="PSR84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2Q2"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Velvet" evidence="2">
        <location>
            <begin position="53"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="407" mass="44167" checksum="3876C602A9262CFA" modified="2018-06-20" version="1">MSRPISHSVGAPHHLPSLSEFDMMTTPSQVHIVDDSPESIGHPVTFSTGQFEGRTLRAELIELQKADLGRKYARKDRRPLDPPPVVQLKLFEVFNHGTQLETHREFESYDDLRGFGLLCHIDLFPVPAQDSLPPPVPSKRKGQSQSQSRTRPTSTSTASASASKSASPTTTPSPSYSLTHPQPSNSSFILPSFGGSNSNSYSIPPPLPSGPSLFSLPPPGNSGVTLPPISSIHTPSSYSSVHLPPMHAINRSNLTLPPLTRQHYSFPPPPPPPPVPIIQPAPPPSTSTANYGEGKAIRAGPNAPEGIVAYLGDHSIKEEEKCTDALVGARISQSSPLEYQGRKHISMFGVRLNLRETERKRRRGGRSDTASPGPSRGRGGRRKRRAAEEEDSDANSSDDEDDDYFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBZ4</accession>
    <name>A0A2R6PBZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBZ4"/>
    <dbReference type="STRING" id="98765.A0A2R6PBZ4"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015321646" description="BAG domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="186"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR88588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26795" checksum="1FEB57879EEAF5F6" modified="2018-06-20" version="1">MQIPTTISPIHFAIPIVLILLRVAYAQAKRLVGSSNKSMTYVVKWGRERLYFPLPSPDSKLSVIRQQVADYTQLPPNSFKLVHAGAVMKDDNALISSYGIKEKSTIAIVGGDNSAPIKSAPERRTEDSIISQIRTELDKVRQTLQPDVDDFLSFIEPTATSSASAPKPAARPLLNKTEKRSDLAQEHIRLGELLLQSLLRLDAINAEGEWEEARKERKGAVREVQGLLDRLDGGWRSRTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGB8</accession>
    <name>A0A2R6PGB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v4881</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGB8"/>
    <dbReference type="STRING" id="98765.A0A2R6PGB8"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR90588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="237" mass="26792" checksum="E55B27DBA36026D8" modified="2018-06-20" version="1">MSSQTFSDRPLKKLLLFDVDETLTPARQTISPEMLSLLRELRKKVAIGVVGGSDLVKISEQLSLGGAIATEEFDYTFAENGLTAFKLGKPLPSQSFIKFIGEERYKLLANFILHYIADLDIPIKRGTFIEFRNGMINVSPIGRNATIAERKGFSAFDKQSGVRAKFVSALKEKFPEYGLTYSVGGEISFDVFPNGWDKTYCLRHVEDEQFEEIHFFGDKTYQVRASSDRHIMEIIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMZ0</accession>
    <name>A0A2R6PMZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMZ0"/>
    <dbReference type="OrthoDB" id="3232876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="418" mass="45701" checksum="59BB90E9F43E032D" modified="2018-06-20" version="1">MLSADSDQREAPRQLAPASSFGASLIEKLRVAIHDSLAAFTGYASSSQPSQSEDARVTSDSNGALIHEPSVAIVELSPAEQRERHKTVMASRYGIRVRDFAYESKLPPVPSYRPPVQVGPRTLKRTRRDYEQTSDVEEDYGVPFTPDLVSSSPRRVKKSKPLQRELTEPVVSSQSQQATGYEFPVQSMRIGCSTPRNGAYLAPSTPPRLAIQVPTSSFSPMVNSMDTFSTPPSQPGLDESSQETEPWVDTPLVTPNGSYQFKFTDTSAVPASQLGDVLPEIPKTSFPQLGLIPLLSSTSLRRGLQRSLSRISGTSSPSRSSSFRQIVAPKSRSRANTRKFPSLSPSTSRASLMPRYHLRNRAAVTSPSRPSGKARRDSHTAAASPSRKQRSPLSKNMQGSVAKLIPVLRRSARKAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PND2</accession>
    <name>A0A2R6PND2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v4535</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PND2"/>
    <dbReference type="STRING" id="98765.A0A2R6PND2"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001522">
        <property type="entry name" value="Probable MIS1-C1-tetrahydrofolate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="13">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="14">
        <location>
            <begin position="147"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR94107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="941" mass="100849" checksum="50FED089BF873DFD" modified="2018-06-20" version="1">MASAKLIDGTALAKTVREEVAQRIKALQAQSPRFQPQLCIIQAGSRPDSSVYVRMKAKAAEEVGIKFKHVTISEDAPVDNVVEIVRKLNSDPTVSGILVQLPLGSHIGADGERTVTEAVSPEKDVDGFHAYNIGHLSSRASEPLFTPCTPAGVIRLLDAAGVKIAGSHTVVLGRSDIVGSPVAAMLRSRDATVTQCHSRTQNLPAIVKNADIVVSAIGKPEYVQGSWLKPGAVVIDVGTNYIPDSSKKSGQRLVGDVDFESALPVASQITPVPGGVGPMTVAMLMVNTLKAAERQWNEMRSRKIKPLKLDIKEKVPSDIEIAMAQTPKPITQLAHEIGLLPLELESYGHYKAKVELSVLDRLSHRKDGKYILVSGITPTPLGEGKSTTTIGLAQALGAHMGRLAFACVRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAVTAANNLLAAALDARMFHEGTQSDKALYSRLVPTKKGKREFAPLMFKRLKKLGIDKTNPNDLTPEEITRFARLDVDPETITWNRVVDVNDRFLRKITIGQNSTEQGHERVTGYDISVASECMAVLALTTGLQDMRERLGAMVVATSKQGDPITADDIGVGGALAVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSILADRVALKLAGTEEGDEPERIGYVLTEGGFGADMGMEKFCNIKCRVSGLTPDAVIIVATTRALKMHGGAPDVTPGKALHDTYTKEDLVTLEEGCKNLVQHIKNSRKFGLKVIVAINQFATDTPAELELVRQLSLVGGADAAVVSNHWAEGGAGARALAEAVVVTCEGSSDFKFLYDLDLPIEKKIETISKEIYGADGIELSEEAQKQVDTYTRQGFGHLPICMAKTQYSFSHDPKLKNVASGFTIPIRSVRLSAGAGFLYPILGDMQTMPGLGTRPGFWEVDLDPTGKVVGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNE0</accession>
    <name>A0A2R6PNE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNE0"/>
    <dbReference type="STRING" id="98765.A0A2R6PNE0"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR94117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="21315" checksum="594CF2651351C75B" modified="2018-06-20" version="1">MTLARMIRLNKVAERPHLEKQGLREMEEKDIPQVAKLYATYMKRFGMAIEMTHDEVRHHFHSGLGEGPRGKDSWKVPREGQVVWTYVVENPQTHKITDFFSFYSLPSTIMKIPKYNILNAAYLYYYATDVAFEEGADEDGRLKKRLQELINDALVIADQCKFDVFNGLSLMDNMQFISDLKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNF5</accession>
    <name>A0A2R6PNF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNF5"/>
    <dbReference type="STRING" id="98765.A0A2R6PNF5"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="201" mass="22145" checksum="21DD119374271739" modified="2018-06-20" version="1">MSQPISILHFTGHQYLRHRLVLSVLSGKPVRIDKIRTDDKNPGLRDYEVSLLRLIERVTNGTVIEISVTGTAILLKPGIIAGGSVTHECPLSRSIGYFLEPVVMLAPFAKKPMQLILRGITSDDRDLSADLIRTVTLPHLQLFGISEGLELRIKKRGSAPLGGGEVQFLCPIIKQVKTLNFVDSGKIKRIRGIAPRQPSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVC8</accession>
    <name>A0A2R6PVC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000438">
        <property type="protein sequence ID" value="PSR97377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVC8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8540" checksum="5D9ADD09AE9E49B3" modified="2018-06-20" version="1">MHLDYEVEMVEGRLEWYAISGEWKGRQCSKDEMQEDLYGDVRIIACIHEAVELLKVGAFDKALGDRALVHCGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ41</accession>
    <name>A0A2R6PZ41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-L-arabinofuranosidase 1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000421">
        <property type="protein sequence ID" value="PSR99314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ41"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ41"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase 1 catalytic" evidence="1">
        <location>
            <begin position="42"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR99314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="15065" checksum="3F3A64713F278CEF" modified="2018-06-20" version="1">MSEYLAVAICKVQVFHRGSTGRSLLDPCKIAQDGSDTGFVPSFVLADSVTNKWGRLRAQLGHPDPYNVQYIEIGNEDFTSTTYDYRWERFYDAMKKAYPHLNFVATAHIDGVSLPAVDVHDFSGPTAFYGMFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZM3</accession>
    <name>A0A2R6PZM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZM3"/>
    <dbReference type="STRING" id="98765.A0A2R6PZM3"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="14937" checksum="D534B5637EFB3CEE" modified="2018-06-20" version="1">MPGTAEQKKAFLSSPKFAVVGASKDETKFGTKVLKWYLEHDKEVTPVHPKENEIQGVTAVRALADLPDPTNTSVSVITGPKITLGLLEQAKVLGIPALWLQPGADDETIVQYIQDNGLADKVIYGGPCVLVEGGAILESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7R2</accession>
    <name>A0A2R6Q7R2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000381">
        <property type="protein sequence ID" value="PSS03898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7R2"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7R2"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="303"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="640" mass="72318" checksum="03008C87D70F4E6E" modified="2018-06-20" version="1" fragment="single">MTAAIDDDFVDVPRVAAIHGVCAMSSCVLSSGDESWSSDNEYVTPPLSLPHIIWNARLHAPSGISDPLPMLIDTSATTVLICDDFVTQLKLRRRPLHAPFRYKAAFGSDICSSSECVKLRVFNSDLSWSSISVLAVVVPDLCSPVVLGLPFYKRNKLFVDPEFSTIIEKVTGRNIMLPLPLPVKPHDSRTARERRQDERAVQLDRDELAQENIILEDMHFQTTRMDVIRELRLKFGEAAGQRAPPKLVSNLSSEQIVAAIQERVDKLAMLDVLAKENAEMCLRFEDCFPADIPHLDELPTHVYHRFHLIDPNMVIARRQYECPKKYREAWRVLLEQHLAAGRLRPSSSPYASPAFLIPKTDQILSDCGKGKFFAKIDMTNSFFQTRVHPDDVPLTAVTTPFGLYEWTVMPQGCRNAPATHQRRMFSAFRQHIGSICHVYLDDIVIWSQTLEEHRRNVETILQCLRENKLYCSPKKTDLFCTALHFLGHYISAKGIEADRKKVEKILDWPIPRSVSDVRAFLGSVRYISNFLPALARHTAILNSLTTKEAEKDFAWTNTHFVAFKAVKELVTSRECLTVIDHNNLGNNRIFVSCDASDFCSGAVLTYGESPESARPVAFESQQFSGAELNYPVHEKVLLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB81</accession>
    <name>A0A2R6QB81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB81"/>
    <dbReference type="OrthoDB" id="3230513at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="343" mass="38111" checksum="2014DD469FB5814F" modified="2018-06-20" version="1">MEPNNGSTSSLASFQDATSGRLKDRVRRKPVPKYLPDPPRKHSSPSPPSPFRQLTALANANIHKDHPPLPDDWQQTIAKALDMERHVERPAAPTPDIESEVDVEAEGGYVTTLNPADPSEKVVEQPKAVPKASSLRGRQTCRRADMADSTLDGPARSMNLEASGYMASSVLPHSLSRKRSMPQMRRPPTPSPSPPKSRLEEVDDEEQLFVAAHPPFRIVYPERSHSSSPDTLHRNAAVFPAFPDSAENISLDVTAVDSQEDVRDTADQSSLHSRRRTPASKSHETSVSVSSHHIDTRTVRTPSNDQRCLLARRIANFWRLLLHILRQIICAKPALPVNRVKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIQ4</accession>
    <name>A0A2R6QIQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000340">
        <property type="protein sequence ID" value="PSS08880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIQ4"/>
    <dbReference type="STRING" id="98765.A0A2R6QIQ4"/>
    <dbReference type="OrthoDB" id="2799087at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS08880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="376" mass="42560" checksum="C92B6856EE136A9A" modified="2018-06-20" version="1">MHDLLILGFDTGQTYKQLAHRHPLLFRLHTKPSSPDGHLIAAHFCSTTDTASIPASPEQPVSLDDLHRHICKWSFRDVESAWISTTFSLPYVLWEGFRRNDRKELYVSIIDSRHRLMEDRAETGMEALRRRGSTGNKKDSMSRKASNFTTAFQEVLVYGYVSSDAIVITLPWDHVERALESQYRDALTLAEGFRGYCRNLEGLLLQVEDPVQFSTGQAISLMGMAIKSASTAAELNVWFDSVLTLATSIFLWPYRGWHGWQALPSFDTLPDDLAIAIQQHPVYVGAWTTLFHSNMDTAMILYAALREFDAPGRSRNVGEWTPLRTHAQLANALQASLKLLEDRPKVQRESQSMDIAQHVRTLTPLYVFPHLTDAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIV0</accession>
    <name>A0A2R6QIV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v3416</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000328">
        <property type="protein sequence ID" value="PSS08926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIV0"/>
    <dbReference type="STRING" id="98765.A0A2R6QIV0"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="85"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSS08926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="295" mass="32417" checksum="728811201D6B600D" modified="2018-06-20" version="1">MSEARRSTRIAAQPKKEEPTTKVTKPARKASSKKREAGDDKAGKDVVDGPAAKKSKAESDEQVSESVGDAKVAEPANKGENLKAIDLGDTLPSLTLKNEKGEDVEVANLAAEKGLIFFLVPKADTPGCTNQACGFRDIYPDFTSLGYDVYCLSADSPTAQTKWQTKKELPYALLSDPERVLITALGAGEGGKTKRSHFIFEKGGKLVEKQNPVKPADRAILQHDMDMIGAEHRRQIRYFAFIQVEGRVALLPPTTGIDTSCLYYNYIDEPRSYKRDWLLQGKAGQEVRAIEQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0Z9</accession>
    <name>A0A2R6R0Z9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0Z9"/>
    <dbReference type="STRING" id="98765.A0A2R6R0Z9"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS18919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11066" checksum="A509F06F35DB8728" modified="2018-06-20" version="1">MATSELAATYAALILADDGVEITSDKLVALTNAAGVEVEPIWATLLAKALEGKNVKELLSNVGAGGAAPAVGGATSAAAGGAAPEATKEEEKKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6REQ2</accession>
    <name>A0A2R6REQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000262">
        <property type="protein sequence ID" value="PSS28488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6REQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6REQ2"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="108"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS28488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="47474" checksum="853DC2DE4D873218" modified="2018-06-20" version="1">MFQYPVDVDYAQSVEEYPVSEAAYYYPPEVDASGMSDRRLHRLARPDVYRHQRPSFYSVYARAARRYGFESGAYAGFAMRNNVVVKVAGLYDKSTDHEVPTEGVQNEYVVPVTIGNPGVTLNLDFDTGSSDLWVWSSELAGVSQYTDTHTIYDPRMSETAQRVYGTWNISYGDGSSASGDVYTDMVTVAGVTMPSQAVECSRSLSSAFLQDGGNDGLLGLAWPILNTVTPQPVKTPMENMMEQGLIEHPLFTVKLTRGHNPGFYSFGYIDYNVTPHAITYTPVDNSQGFWQVSSRSFAIGSQTFDRRGNTAILDTGTSLCLVDDDTVRAIYGEFPCRSKLEPHSTSIPLADSIEGATYDDQHGGWKYPSDVSVPNVAFAVGDKYYTIHPDDFGFGSAGDGYILGGIQSRGDMNYDIFGDVFLKSPRNRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHT2</accession>
    <name>A0A2R6RHT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v2730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHT2"/>
    <dbReference type="STRING" id="98765.A0A2R6RHT2"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="222"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="315"/>
            <end position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="331"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS29582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="501" mass="55202" checksum="A1292E51C62D3917" modified="2018-06-20" version="1">MEFPGPLLDISLRTSSRCYSSRPDSSATATLPRPRLNYREISETVVFKSHNAFNRNAPLPAGAIQTIAKLYQTKKDLTDALNPRIHTRSTIGERIRQNAKDPDAKKAALEDAKVLKAEITELEQKLLEVEDRMFHLALAVPNDTHPDTPIGPESTAVTLSEYGPPPIPASPSRDHVSVGRTLKLLDLEAGATVTGSSWYYLLNEGALLEMALTNYALSIATKHGFTPVTTPDVIRADIAYRCGYQARDPQGETPASQMYHIANTTARDTTGGSPSSPELVLAGTAEIPLAGMFANKIFLPQELPAKIVGLGRAFRAEAGARGTDTRGLYRVHQFTKLELFVVSTQDQSEAMMEELRSVQTEIYSGLGLTFRVLDMPTEELGASAYRKYDMEAWMPGRARWGEISSTSNCTDYQARRLHIRYRRPVSLPSDTTVQEQQSKSPSLPFVHTLNGTAAAIPRLIVALLENGARFDDAGEVVGINLPKILRPFWVDGRNRTLVNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHW8</accession>
    <name>A0A2R6RHW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHW8"/>
    <dbReference type="STRING" id="98765.A0A2R6RHW8"/>
    <dbReference type="OrthoDB" id="2756128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS29613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="658" mass="71334" checksum="D1DEC3E53C399224" modified="2018-06-20" version="1">MAKPKPLTDLGSTATSPPCYSNFLRRSSRHHKPSSSKRQSYSPYPGPSSSLLALLATVAASSSSVDGRPLAADSQPPDFLCPLLPIDISGDPSLSPSKRSFRGDEVDGDYYILRPTPTRAKRAIKRRALVADKYIQGDDGQWRKEHSWTLYGSTYCECTDTATSAVQQVDDQVQPTQIVSTTPASSAISSSTDMTGSLPSGWYNNHPPQKDVLTPIILTLSLLLAIFICVLIFGCVVWRRKRRVAEQKDVEKKCRKYLDDDLDETEEVKRMRSQQRMWAKATARWKAGVRQSARRRRKQPSTASMRETDTQSSVSLPSQHSFTVSRRPSSISHWTLPPDTTSIPPATDSIPACGETPHTHETDVATDGSLDGSRPSQPPEYPVDGTSEARLTRLDSAIGRSLASEDGTPAVTISKSASTSREIHCIPANAAHVATDDKTVLARMANLASSPPPEELPLHGNPDQSDTINAAGPLVPVLDEFEELPLEIQVVDEDGTSGSNSEWCGAASNALLSPSTNLPVPTYSREPSPQPPIFPAPPSKAQLAAPHFLQYPSFFEEDLTGFESNTLPPAPAFEAPSAPPLDDTLDEDAVPCAPPLIDEEEEIQLGFTHVHAPSSSSTIISGRDRIPSSSTDFPESPSRGRTSVPFSRRSANPPDYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI72</accession>
    <name>A0A2R6RI72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI72"/>
    <dbReference type="STRING" id="98765.A0A2R6RI72"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS29721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="288" mass="31255" checksum="86AF2D611A8D819C" modified="2018-06-20" version="1">MSLARLGLHYGRTTAGTTLLASPFSRQFHGSLTVMARQKKQRVVAPSKKQLAAKARKKASKARKSIYDSEKMTLDNAISVLRAVEVASPNATYELVVKTAMGRGMAIPKGRYSLPREAKRIVGDRILVFAEGKAAEEAKRAGADVVGGPEIVDAVVSGRQQASMYLCTPDLIRAITPKLGRVLGPRGLMPSERRGTVTDDVAGYIRRLKGTMEWKGDKAGTIRAPIAKLHFPVEDVVKNVKYFLSIVRRATGNQRSTETKDSGPKPTNSITKIMLSSRQGPGIQLSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPY8</accession>
    <name>A0A2R6RPY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000198">
        <property type="protein sequence ID" value="PSS32093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPY8"/>
    <dbReference type="STRING" id="98765.A0A2R6RPY8"/>
    <dbReference type="OrthoDB" id="3174539at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015313846" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="58842" checksum="BD4A38A3BD51DD5E" modified="2018-06-20" version="1">MHRCLLVTEIFQLIAQFADLAPSDHPSPSAVLAQTCRHFHEPALDIRWRALISLCPLLACFPDDVCVKDTKETYTFTSQPILPAHWTRFQHYSHRVRSIHCSDHNSGLTSVGFRTLDLYRPGDPKIPLLPNLQELYWDDFRPGVAPYIRLFIQPALVTFHIISVSNPSLIAGFLDALARHAPALERLRIRSPRARPSPVQHGEAASQRAIMVTHTLSRALCSLRSLSELVIRVPPLGADHLLSLAHLPNLEILSCSLLDPGGDSMDASSLASSDADLQWWQFPALRRLDVTARDISAVSALIRAISSSHLIKISVHLETQPKATCVQDLFHALSTHHRNMREISILLSLRNSSDLMLNATSEGHLLTSTTLRPLLRLHALSHLYFVQLPFDLDDDFVQHASLAWPSLKKLSLGTMVRGRTTGVTMDGLRALAARCVCLQELALAIDIVPQNGLLGRRQCEASNLKTLDIGCTSIPADDVGRFINFVAQVFPHCNVCDSHDPFDNVRNKQIERLKLGIVQTHENGYSNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQE4</accession>
    <name>A0A2R6RQE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000179">
        <property type="protein sequence ID" value="PSS32242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQE4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="22647" checksum="4C9B8D6FDAE70DAD" modified="2018-06-20" version="1">MDDILSILQNVVFAVFSALRVFALWDRNIPMTLLVLTLNLVPVAVDIFDFSKDTAVFNTDPIFGSFCDNINGLSANVYFDIIFVINITQVVVTTVPSFQNFDFVTAVISTLQAILISRFLLNLRQVGSPEIDSQEAFNSQFSVPGFRVPSLSSIVGNMGEDLDHGGPAEEVEDEVENYSGSIQVEEGAVPEAIIETHPFLDGSDSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVL0</accession>
    <name>A0A2R6RVL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVL0"/>
    <dbReference type="OrthoDB" id="2802674at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="425" mass="45754" checksum="6FFC052D4FC8CC07" modified="2018-06-20" version="1">MAVIVACHIRPSPPPIHDHIPFGNIPNISDPSVPRSVLAHSLLAAAVAIPALTSTLEPEYCLSSKRKSHDDEDDENVHATKRFKLDSENDSLFGPLGPSPTPPPVTANPNNALSVTIEQAIAAIFDSPEVAPPPPSPQPQHATLPSDCLAPPRLPQSPLASPPSYAHAQDSEQPPNARPLVPPQSHRVVEPPLWKIACRTRVEHIAELYGYPTIRASVAHQASRTTGSARPDASPLVQTSTHSSGSSDLRLEIYTPSSYASSSTSTSELDDDEDDDDDDECMKSEFEMEDDVDMSFDLDDDSDSEIDEDEDESRPCIHESVLDVSLSETSSSSSDDSSTSSSLPRTPPLETSTPNHILRPGIPPFTPLPSLSTIPVLCLRTYPTAAKHGTPGKVAPWARGVLSRNSLMAQARIGCPGQPRSLDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVP0</accession>
    <name>A0A2R6RVP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000156">
        <property type="protein sequence ID" value="PSS34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVP0"/>
    <dbReference type="STRING" id="98765.A0A2R6RVP0"/>
    <dbReference type="OrthoDB" id="3244653at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="8193" checksum="912617B1453C01A9" modified="2018-06-20" version="1">MVQTYGIVPESARSDVETSRVAEESDALLGSDAGPVKPKKEGHATIQSSVGNLANTIIGSGMFAPISPYEPSTESILVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZF2</accession>
    <name>A0A2R6RZF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000127">
        <property type="protein sequence ID" value="PSS35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZF2"/>
    <dbReference type="STRING" id="98765.A0A2R6RZF2"/>
    <dbReference type="OrthoDB" id="3262920at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="102" mass="12058" checksum="56BA1A66BE4A5208" modified="2018-06-20" version="1">MKSKPMKSFEEMIPKQYRPFSKVFSKEESKRLPEHSNQNHIIELIPGATGFHSKIYPLSRDEDIKLKKFIDENLHKGYIVNKLRLKKPYLTCLPTLTYSPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZQ0</accession>
    <name>A0A2R6RZQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000122">
        <property type="protein sequence ID" value="PSS35511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZQ0"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="15909" checksum="E40B2CAAE8790B76" modified="2018-06-20" version="1">MDPHFMSNLSRLGPVKVDHHMRTFQPAMANQIQHIYEARLQSELEARSPQTPRNHLLAATLEDLLEERKISRTQEQVTDLAKRYNIDVARLENLARFVNTPNVDPESVVKTVDDDGTERVTMKTIWVDPPVPHTSSNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S398</accession>
    <name>A0A2R6S398_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S398"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="637" mass="69808" checksum="F475AB3433240A33" modified="2018-06-20" version="1">MVTSPVDSSTSGKENHPALAVTTNLDKPRTEKQKKAKGKESIVVPLPTDQAFDKLLDDLQIPRPLRTKLATMEPSVKAAFIKSSHTLSKGTTPIITPISPPGLRRSHSSQSISSLASPRPSRLQLGNESDVDMLRSPRSADQSPTDSRGRTFVPPFAFASSSQTHGRGMSLDMPRAQPNASYADLTAIQRESGNVKHAKEKSGKCGPLSPMRYCSILTSMSSTQLDVETVKKLRLLLRNESASWTEDFVFKGGYSALLTRLNDILEVEWREEQHDDQVLHELLRCVKALSTSAVGCEALRSCCPTPFTQLISLLYSDKKPGDIGTRQLMIELIQILFELYPPSSLPSAGSPLLHTQSTVHISHNHARQTPWHNTVTGGTLPQPSSLITLPAPHSTVFSLIRALLLIPAPPPSEDPHIPVSPHAFIEELHIPRIYKTYLQELNDICRDYFWVFCHPNNTIWDLNETDEGKVEKPRAPGGMTGGVEFEAMAYMTTHFKLLNSIAKAAQDLNVSKEHELSAHRLHSDLFLSGIDRILLLASSVQIARKASTTYYPTLHLEIARYIAAASRAGYELPWTVSRFIGPPPSAMCKPGCGSRATSRAQGQAGTPSAPSSPRKRAPGTGTSPQLPTPRKVTPMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3D2</accession>
    <name>A0A2R6S3D2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3D2"/>
    <dbReference type="STRING" id="98765.A0A2R6S3D2"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="17808" checksum="0D5E31801D4FD7A9" modified="2018-06-20" version="1">MSETYSPLMNTQPALADLLTIEPSASIFYSYARELELSAEFADVNTQRTLLVPTNKAVMALARKPHQGPEPDNEGVIITEEEFDAQSKKNVERWISAHIIPQSPISLTEGTYATLLEGHSVDLKEIEGKPDSPEWTRVVLNGVIHIVAAKKVGGPFARAQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3G4</accession>
    <name>A0A2R6S3G4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3G4"/>
    <dbReference type="STRING" id="98765.A0A2R6S3G4"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS36795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="610" mass="62606" checksum="60942B26F8591C8E" modified="2018-06-20" version="1">MEEDSKPTVITSGEVWTPNTGWHTIPLEQVEAHATTNGVVAHLEAKAAEANGSAEEEEDDIFPISMLQEAAPKEEEEEEEEEEEAEPEEEEEESDDDVEIIMEPPTRSLDFRQQRPAVGRQPSTSSISPTKQIQPEASLTTEYTPRDRNTVLKPPATTASGAPPLATTPGASAAAAERSSALPSDGVDTSTLPVATAPPSHPNIDPSVVGTLDGRSILEVDLNALAEKPWRRAGADISDWFNYGFDEISWEAYCFRRRETGDIASLLKTNVLNFAGMPEDQLAALPPEIRTMVMAGASAMMSSGNGGNAAAMLPAAMNMNGGMMNPMMDMGQMMGPMMHDMGAVGMMNQGMGMPMGPDMGGGMGGGMGGGMGPGMGPGMGQGMGQGIGQGMGQGMGQGMGQGMGQGMGQGMGQGIGQGMGGQGMGGQGMGGQGMGGQGMGGHGMGGQGMGGQGMGGQGIGGQGMGRNDGALSGGVAMSSAGSAQGQGRTATPEQSSMTMGGEGFVGTPQGQGLHHPHGQPGQGMMGIGMGGEFGQVAPVRPASPLPPNVPTGPRNKNKYKDIDGSAPAVDGLDYGGGKDRSTPPEYDERSSSRKRRSSPGLDENRGSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4B2</accession>
    <name>A0A2R6S4B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4B2"/>
    <dbReference type="OrthoDB" id="2563021at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="182" mass="19478" checksum="93E45711657029F5" modified="2018-06-20" version="1">MSSPPHEHYRDLPTTPFSPDSRLSRDPSYQIEPFVLPADHEFGARPSSSSTPSNTAYNSTGSSQPHSHVGDCSRSPDATSPSLSTIPTIPPPLVAPSRPLAAEARTNSQVYVVHHDAGRPPVTVYTADGTEVVELPPRYNESNPGTSATSTALRSGIVPPLQVQERRQAALVPPKSVRRVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S507</accession>
    <name>A0A2R6S507_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000051">
        <property type="protein sequence ID" value="PSS37377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S507"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="5873" checksum="BF0A2A44AD4E6034" modified="2018-06-20" version="1">MVKKLWDGVGAVAGGVGDAVRQWPLEPATGTIEDWVEVGAICGHSLSGKKPLHNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5X7</accession>
    <name>A0A2R6S5X7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5X7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5X7"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="100" mass="11315" checksum="938DDBDAD8926BAB" modified="2018-06-20" version="1">MSAVPKASLYYYKQSIWASVALLALEEKGYAPDEIDLKEVDLFKGENFSPSYLRINNNATVPTLVVPLETTLDPEVESRYKAIKDTKVCNLNIDHYNQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S761</accession>
    <name>A0A2R6S761_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v34</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S761"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="476" mass="54319" checksum="8CC1091D74BEF9B0" modified="2018-06-20" version="1">MSMIDFSAVGATTPSLVEMKKLTTPPQLYDHFEMYHIPGVDDIWKRIVVRHPQQNSCDKDDKDEVQCQDRGSRRSRDSHTMDVDDSDDDSDDDSVSTQSDDDNVGSDRRCLSCSCFLDFLQIHPQIASSIQILDYIGPYANKNQGPLLTEMPTIGRPVRKCDAEVLFGILKHLPNLRKLHLEYIVFHPRAKPSETHDMIQLDFVKITLPYCEDPKLANELALLELLRLFKDIGTLELDCYTGPYFEDWGAMPMPERLRFSELRLHEFHDIYAVVSVMRYTKIMNKLRSLTINAVLNSSEGQATALVEMLGAVSDKLEYFRCGIERIFDDDEESYEEAPVPFTEIMKGAQWSSLRELDIRVSVTKTSECDRYWSELCAMFMATNIPNLERITLGVSSGGGKNSTNKLYCAPTSWGLRHLSDSLQRFPRLEDVVFTGDLSSSFRTVIETGMGNLKMLRLLSFREDVPRGSNVLRFVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDS8</accession>
    <name>A0A2R6NDS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDS8"/>
    <dbReference type="STRING" id="98765.A0A2R6NDS8"/>
    <dbReference type="OrthoDB" id="2749068at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11495" checksum="81E7CEFFC623C5B7" modified="2018-06-20" version="1">MLKCTVVRLGNSGLKVSKIILGTMQYGNKSWQDWLLEEDEAIKHIKYAYDHGIQTFDTADVYSNGLSEKILGNAIKQLNLPREELVIMTKVPDQCNLRCTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDW4</accession>
    <name>A0A2R6NDW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDW4"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5701" checksum="0793C3E76434BF2E" modified="2018-06-20" version="1">MSVQTSLDNFSAELNNGFSKDLFEFFEKHLGVKDNRGYVMFVDPGRENIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE67</accession>
    <name>A0A2R6NE67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001337">
        <property type="protein sequence ID" value="PSR70655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE67"/>
    <dbReference type="OrthoDB" id="10499689at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="374" mass="39737" checksum="41599317D9D97E55" modified="2018-06-20" version="1">MSGFRFPRVLVCGPEISDDSNDNSLPLWYQITIALARTYIQTLQIDVAAHISPALDLAQIKATLSQLSPEINTDGLTTTPATGSLSLKAHHTHVVLCGITPLSSTPIPPDVTAIYIPTPSSPVSPAFPFDQLGSRGFVVLLEPEARNLLNELDPATAAGSAVTTLRARALVRSLVARSSLKLLQGVVIARGEHAVDGCVASAKVMVPPPFDDDDDVDDEDTEERYEFDIPKPIFEGPLETEGAYAAFAGKFIASLVTASASMSPVSVHSESSFSFQLELASVAAVTTALRPSSSPTDLVSRIPTLSQLDPNIQQYMFGRPLLRPGEPVPPRGARPVQVQISWPATALSPPTSPILGAFMRGRGMVRGAAQGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEV7</accession>
    <name>A0A2R6NEV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v13248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001305">
        <property type="protein sequence ID" value="PSR70886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEV7"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR70886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18813" checksum="9D476A13816AF3A5" modified="2018-06-20" version="1">MHRAEAELRTRLLGEPAKHIRPLSETRAIDNGANALAEGFLFGVAALLIIGETWRSSRSQTKRREGVDDRLDELQISLQSLAERVETLSKDFEERWSEEKQRNDELTRILERIVEIGLRGGWAEFEGTPLALPRIQLTSRSGESSPSTTDTRHEISNTSSEPEQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFK3</accession>
    <name>A0A2R6NFK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v13006</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFK3"/>
    <dbReference type="STRING" id="98765.A0A2R6NFK3"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001378">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="16">
        <location>
            <begin position="175"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="14">
        <location>
            <begin position="397"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="557"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="943"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="950"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1001"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR71160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1011" mass="115416" checksum="F31CB4D9CCF084AD" modified="2018-06-20" version="1">MPTAASTTLTVESIQAYFPLTFPTPTPTSHLDLVSTRDLHREEDLLRNPNSFRTWWTAIQNTKEAAATLQKTEALLDLPSADVAALLGPLASPNARKSLQRLTYLYEAALVQFPASFKLWKSYLQTRMSYVLGKLILRKRAGGKKKFPEMGQALEDEQDDLEKWEGGLDGVVGWEEWKSLVATFERALMWLPRMPRLWLLYLSIFNHPFCPPQLSHTHARRTYDRALRTLPPSLHSRIWVRYLLWAESRGGSTTVAIYRRYLQVDPSITERYTALLLSPENPTPRPLEAAKLLLSLARKAAKNEYTSPEGKSPYQLLCEWLEVAEQYAEEVGFDVDETIISNAAIAKAEEEELSAPQPSAEPAAVNGTLIRFAGPAVAVDSDGKILSPYEEDEDPTSTRKLNIERIIKKDGLEIYKDQAGRLWTGLATYWIKRGEFDHAKSTFEEGIASVLTIKDFTQIFDAYAEFSESLISAMMESLANPDEDEEEDEVKETEAELDEKMKEFEELMDRRPFLVNDVLIRRNPNDVQEWEKRVALWGEDDEKVVETYTQSLSTVNPRRATANFHRLYVNFAKFYEEGGTTGEAEPDLDNARKILEKATKVNFKNVDDLAEVWCEWADMEVRHENYDEAIRVMQRASATPKNVKINYHDHSLSVQTRLFKSLKLWSFYVDLEESLGTVESAKAVYDKILELRIANAQVIVNYAAFLEENQYFEESFKVYERGVELFTFPVSFEIWNIYLAKFIKRYGGEKVERTRDLFEQALEKCPPKSCKPIFLMYATFEEEHGLAKRAMAVYDRATQVVGDQDKFQVKILLKFETNALLNMINSQLFTIYIAKAAANYGLPSTRPIYERALEILPDRQTAEMCLRFANMERKLGEIDRARAIYAHASQFCDPRVNPNFWAEWNSFEIETGSEDTFREMLRIKRSVQAQFNTEASYLAAQMASKQGAGEVEEEEEEPADPMAAAEKQAGGVKGPAFVAAKENPNVPLREEQAQPAAGNEDEIHISDDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFS2</accession>
    <name>A0A2R6NFS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v13007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFS2"/>
    <dbReference type="STRING" id="98765.A0A2R6NFS2"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR71161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="303" mass="35997" checksum="0077683B394AEED9" modified="2018-06-20" version="1">MLYVQKKNEDLSRGAFDLTTQMLRMNPEFYTVWNYRRHIFIQGIFPNSSPAAINELLSEDLGLTAAFLKQHPKVYWIWNHRRWCLEQVPDGPLDEDKDGWRMANWNKELFLVEKMLDVDPRNFHAWNYRRYVLASIPVRRSQVSELSYTTRKIESNFSNFSAWHQRTKVLASLWQAGELNVAQSREDELDLVKNAMYTDPDDQSVWIYHRWLIGDGDDPLLLQREIASIQELLDEQPDSKWCMESIVYYKTLLLRRHLSTMDTSVQQSLVGECFDLLSKLQYVDSNRKQRYIELSDEIKNTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG02</accession>
    <name>A0A2R6NG02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001304">
        <property type="protein sequence ID" value="PSR70912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG02"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="225" mass="24114" checksum="ECCCEE8C079F17BC" modified="2018-06-20" version="1">MLQRNTSVASSCCCSEKPSKSPEMANIVQLVMKNRHSQGTPPGGHAIPEDDPRVASPTVDRLSTSPPGSPPSFPSSPPSGMYWSLPQSPKLYFEDRLYSSPEPMSHSLPVCPVAGRPDSQVKDGSRSAVYATSPKPFSPPSLPSLSLPSSEDDSDEDRRSISSALTASSLCSFVGSMPSPIAFNSCGEPVQGVCDGYVGGFHHRTLSMGYEEQEAWKPHAMLWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGG3</accession>
    <name>A0A2R6NGG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001282">
        <property type="protein sequence ID" value="PSR71480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGG3"/>
    <dbReference type="STRING" id="98765.A0A2R6NGG3"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="284" mass="31521" checksum="1FA7B37D0FD6473B" modified="2018-06-20" version="1">MSSIPTLPQALTVFSRELFTTLFHPRFLFFLPCLPLHIPVYITGSLSERLLGIPGEEESKAQRKAVCSGLVFGIISSFCGAKLVKISMDQPAWLLSYIRKAGLGFLTIREGVEPIRGARKVLSLAFMMYLTTRVLFRWHNALIGGSQFSITTEGCLSNFNSFKEITGSKAAILPPLRSSILIFCDRYRRLAASWKILLGVLSPASSDEKAAEISSITRPPIPASNPFVKRKEDTGGDLPRVAAIHAGTQARMETRRIPSRTLARQLFSARTEAEYIVEKFRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGV9</accession>
    <name>A0A2R6NGV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v12545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001266">
        <property type="protein sequence ID" value="PSR71573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGV9"/>
    <dbReference type="STRING" id="98765.A0A2R6NGV9"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR71573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="252" mass="28294" checksum="14EC05C01E4D2B76" modified="2018-06-20" version="1" fragment="single">MSVLRMIKLFGWDSRVNDEVTAKREEELKSIFKTKMLRLANNIINHTVPLVHMVVTYATFTLIMKQDLTASIVFSSMTAFNMLRLQMLRLSTMVPGMITANVSLGRVADFLQNTELLDTFAKQATEDVVIDASAVHKDELGCANAHFTWTNDPTDGTVTPSRQTFRLRIDDDLIFKQGSFNLIVGPTGSGKTSILMALLGEMHYIPLGPNSWINLPRDGGVAFAAQESWVQNETIRDNILFGAPYDEERYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGZ4</accession>
    <name>A0A2R6NGZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001262">
        <property type="protein sequence ID" value="PSR71591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGZ4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="10154" checksum="A07F977F118BED56" modified="2018-06-20" version="1">MGRARNGLPNGTPKVWLDSPGPTSSRSGSHSHSHRPLSPTHTSTGAPDALNASMAHPVQGPHDGGYATQPITRPRTRVSELGVTGSFGSYELLEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH01</accession>
    <name>A0A2R6NH01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH01"/>
    <dbReference type="STRING" id="98765.A0A2R6NH01"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="11147" checksum="F4BA688DA309903B" modified="2018-06-20" version="1">MQDALEALDTYKEKNPSKVVVRFKAVGNAPIMKRNLYQITAANKFQAVIQFLRRELGWKAEDPLFTYINLAFAPAPDDTVSNLFKYDGCVGLISFTLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH47</accession>
    <name>A0A2R6NH47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydantoinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001266">
        <property type="protein sequence ID" value="PSR71578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH47"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="193"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="3">
        <location>
            <begin position="713"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="904" mass="96376" checksum="D9F8BA9F27C13E62" modified="2018-06-20" version="1" fragment="single">TNTDGVLIDVSRTLEETRGVLAYFKSPTTPNVSDGIEAAVRQVLEIASVPPSNVACVSIGTTAFVNAVLEADARRLAKVAVIRLCGPYTRQCPPFIDFPVRLRALTEGHVGYVDGGFEIDGREIAALNESQIIEQCTIIKEKGLRNVVVAGIFSPLDNEGKQEVAAKHIIERELGAVNVVCSRDVGQVGLLERENASILNAAILTFAQRTIKGFQRAMRALDLTCPLFLTQNDGTLTSAAAAARLPIRTFASGPTNSMRGAAFLAGLDDKNTARQGKSNIVVDVGGTTTDVGVLLPSGFPRQAAAFIEVGGVRTNFSMADVQSIGLGGGSIVRVSESPKGRQVSVGPDSVGHHLTRDAKVFGGNVLTSTDIVVASGHADVGNKASVRDIEAEVVAKANGVIKKLLEGIIDKMKTSPEDVRVLLVGGGGIISPDKLSGVAEIIRPPYFDVANAVGAAMAKVAGEIDTIELLQGRDIDQVIGAIKLQSIEKAVKAGADRASIQVVEVTNLPVQYVTNQATRIIVKAAGELAIDALVSEDVDNPAGDDAGASAEVAETQKLISAVTVEEEIESINIEEYRPSINSDRSWQLSELDLEWIAEGCGVLGTGGGGSPYPPFLVARQMLREGKKIPVFDPEDVPEDATERLQGGSEIPASARALMKYMGMDDFAGAISDEIGGGNGIQPMIVAAELGKPVLDADLMGRAYPNIMPSASNPHSVENILRTVTTEMGSRSGVSMAPLTRKTCQEYGITRSVSQAWRIGRAIALCRKKNEIKNVPSAILQLQNGECLFVGKIFNVQRVRPPKYFFSDGAEHHEIEQEVRKGFTWGSVTIVPLRSDEEEEPDITENSVTRKWGPEDKLTIPFQNENLYAILESPTGSKKILVTVPDLITVLDSQSGSSIGTQDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHM7</accession>
    <name>A0A2R6NHM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHM7"/>
    <dbReference type="STRING" id="98765.A0A2R6NHM7"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17714" checksum="84E4160BCE99E184" modified="2018-06-20" version="1">MSKVWFITGASSGFGRLTAEICLKNGDAVVATLRKPEVLDDLKAQYPATRLLVLKLDVKNAQEITDAFSRAKEVFGRLDVVLNNAGTGFVGEIESTPDHMARSVVETDFWGAANVSREAVKFFREVNKPVGGRLLTVGSFGGLTALLCAGYYTAAKHGTSIFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHS4</accession>
    <name>A0A2R6NHS4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHS4"/>
    <dbReference type="STRING" id="98765.A0A2R6NHS4"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="1">
        <location>
            <begin position="108"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="195" mass="20698" checksum="C05E496B349A05FE" modified="2018-06-20" version="1">MAATGCLASPPCDNGDGRTEALCSQYINPFSVNEYVWGTLLGIEVSSPNVLMADRIEFWDDIDGCSEPQTTVATCCVSINGGIGVDCDGPETVLPPIEDPSYDLPEWWTVAFPCAVDVPERVLSDVIVSYSPSTAIPYECALSCEAQGYYFAGLEYGDECYCGKGYSGGIPPTAANVSDCSMRCAGDYFYACGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHT0</accession>
    <name>A0A2R6NHT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">JAB1/MPN/MOV34 metalloenzyme domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v12156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NHT0"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="JAB1/MPN/MOV34 metalloenzyme" evidence="8">
        <location>
            <begin position="2119"/>
            <end position="2253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR71946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2355" mass="272107" checksum="AB480C709C36C23E" modified="2018-06-20" version="1">MPPPPPGMSMRPPPGMPPPPPGMPPLALGQPSGSRMSAESLAQKSQKWVQMQKKRYGEKRKGGFVDMGKQDLPPEHVRKIIKDHGDMSNRKFRNDKRVHLGALKYVPHAVMKLLENIPFPWEQVREVPVLYHITGAITFVNEIPRVIEPVYHAQWSSMWLAMRREKRDRRHFKRMRFPPFDDEEPPLDYGDNVLDVEPLEAIQLEFDEDEDAAIIDWFYDPKPLVDDKTAVNGSSYKYWSLTLPVMANLYRIGRTLLSDHTDSNSSYLFDKKAFFTAKALNMAIPGGPKFEPLYRDMDTFDEDWNEFNDINKVIIRQQIRTEYKVAFPHLYNSLPRSVRISPYHTPKNVYIRTDDPDLPAFYFDPLINPISLRGSTPKNAPFVSHEDTVFGPNGVDDDDFELPEVVEPFLEEKPLENDLTADAIALWWAPEPYSRRSGRMRRAQDIPLVKNWYLEHCPPGQPVKVRVSYQKLLKCYVLNELKSRPDKAMTKKNLFRQLKATKFFQTTRLDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNMNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDAHVQYRLGNVDAFQLADALQYIFAHIGALTGMYRYKYKLMRQVRMTKDLKHLIYYRFNTGPVGKGPGCGFWAPGWRVWLFFMRGIVPLLERWLGNLLARQFEGRNSKGIAKTVTKQRVESHYDLELRAAVMHDILDMMPESIKQNKSKTILQHLSEAWRCWKANIPWKVPGMPTAIENIILRYIKSKADWWCSVAHYNRERIRRGATVDKAVVKKNLGRLTRLYLKAEQERQHGYLKDGPYISAEEAVAIYTATVHWLESRKFSPIPFPPLNYKHDTKLLVLALEKLKEAYSVKGRLNQSQREELALIEQAYDNPHECLSRIKRLLLTQRAFKESGIEFFDTYDKLIPCYDIEPVEKITDAYLDQFLFFEADKRGLFPAWIKPADTEPPPLLVYKWCQGINNLTDIWETSEGECNVMMETVLSKVYEKIDLTLLNRLLRLILDHNLADYITAKNNTDMAHTNAYGLIRGLQFSAFVFQYYGLVLDLLILGLQRASEMAGPPQMPNNFLQYRDSATETRHPIRLYSRYVDRIHILFRFTAEESRDLIQRYLSANPDPTNNNVIGYNNKRCWPRDCRMRLIKHDVNLGRAVFWNVKQSLPRSLTTIEWEDTFVSVYSKENPQLLFSMCGFEVRILPKIRTMSGEQFSLKDAVWNLTNEQSKERTAQAFLRVSDDGVQQFNNRIRQVLMSSGSTTFSKIVNKWNTALIGLMTYYREAVIHTNELLDALVKAENKIQTRVKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGVTHFRAGMSHEEDQLIPNLYRYLQPWEAEFLDSARVWSEYSMKRKEANAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDRGWRVRTDWKQYQLLKHNPFWWTSQRHDGKLWQLNNYRVDVIAALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMRYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEPLQIETVQKETIHPRKSYKMNSSCADILLFSAYKWNISRPSLVTDSKDVLDGTTSNKFWIDVQLRWGDFDTHDIERYTRAKFLDYISDSMSIYPSPTGVMIGMDLAYNLWSAYGNWFPGLKPLIQQAMAKIMKANPACHVLRERIRKGLQLYSSEPTEPYLNSQNYSELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRSGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALVRSLPVEEQPKQVIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACMKMEKFGDLILRATQPQMVLFNLYDDWLKSISSYTAFSRLILLLRGLHVNNEKAKIVLRPDKNTITEPHFVWPSLSDEEWIKVEVALKDLILADFGKRNSVNIASLTASEIRDIILGQEIAAPSVQRQQMAELEKSSEAQSQVTAVQTQTTNIHGDAIQTVTTTNYEQQVFSSKSDWRVRAISATHLPLRLQHIYVSNDDVKDDAASYTFVLPKNILRHFVTAADLRTQVAAFLYGVSPPDNKQVKEVKAVAWVPQRGNNNSVELPSQLPRDDFLLKDLEPLGWIKTQALELNHLSPTDITTHAKLMADHPEWGPSSICLTAAFTPGSVSLSAHSLSVAGFEWGRKNVDTSPNPLGFNPNMSERVQLLLSDRILGMTLIPEGRVWNYGVGLTQLWSPNISYSMTLDTPLLFWAEEHRPAAFLSFANLEVGDDSADVENSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHZ8</accession>
    <name>A0A2R6NHZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001229">
        <property type="protein sequence ID" value="PSR72016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHZ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NHZ8"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="215" mass="23013" checksum="85BB600604984FEE" modified="2018-06-20" version="1">MSLSAIPTLFGVRGAVAVVTGGGTGKLNYIPKLFDRYCRNGNIIPVECDISSPKSLQSLANTVKARHGYLNLLVNNAGVALNLLPKLPTPKTGDIKSFQRALLNAGTPQDFATTFNVNTTAAYYCSVLFLDLLDAGNRRGNMRGVSSQVITIASGGGYRRDDKVFSVSYTLSKAAAIHLGKLLANFFKDWQIRSNVICPGVFPSCMSPPSTFMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI16</accession>
    <name>A0A2R6NI16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI16"/>
    <dbReference type="STRING" id="98765.A0A2R6NI16"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="136"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="25553" checksum="6C22E304A6947EB4" modified="2018-06-20" version="1">MPSTMVIPIPVDRWDSEAVIEDDESSHRRQFGTIHNAAWQPVWHSICSEQNLVGVINILAPVTYITSMNPAVARSSLTMDWAIAFRHHGCAMANYPSLLIEPTSTPGDAEYGIGVDCDGPVTVLPPASQETPPYGWFNVIPCAVDNPDRVLSDPVVFYRPSNTVNDCLNFCASQSYHWAGVEYSDECYCGTGFTNQKSPPFANDSDCNMRCSGEYQDLCGGPWRMQIYSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI68</accession>
    <name>A0A2R6NI68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI68"/>
    <dbReference type="STRING" id="98765.A0A2R6NI68"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25523" checksum="ED292AD0B689FD28" modified="2018-06-20" version="1">MATYLSEAGPPSYQLGQASVGTLSSAQSAHQSLEKAAVKSLATDDKEKFSYTSTIEDFPEGGLRAWLCVFGASIVMFLTYGMMQAFGVFQDYYAKHLLRNHSPSEISWIGSVQTFLLFGLGVITGRCFDNGYFFHTIIPGSLIYTFSLFMLSLCQPGRYYQFFLSQGVGLGLGMGMLAVPSASIASHYFRTNQARANGIVFAGLLPIGTSLGGVVWPIILNRMINGPLGFSLSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI92</accession>
    <name>A0A2R6NI92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001213">
        <property type="protein sequence ID" value="PSR72117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI92"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="8959" checksum="E2EB5ED12633F1E8" modified="2018-06-20" version="1">MPILTDKVFSAVVRRLGYLEPATREVALWIEPLNPYVISLQVSSQKDVSAGMLECLCARQYGIVESQREEARAKFSWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIC9</accession>
    <name>A0A2R6NIC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001213">
        <property type="protein sequence ID" value="PSR72119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIC9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIC9"/>
    <dbReference type="OrthoDB" id="3344688at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF491">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27178" checksum="75B31B408C1F8AC5" modified="2018-06-20" version="1">MQQASLPLIQKKEDMYMGLKANKKYMPHLIAALRSRFELSEGGQIHYLLGMHITRDREKRTISFSQSAYINCILTRYQFDEIRTVITPMDPNVALSKEQCATSERQQEEMKNKPYREALGALMYASVGTRPDITYTVSTLAKFSQNPGPTHWTALKCVFAYLHGTQHYTLTLGGISSPILTGYCNSDGMSNPDRHPITAYVFTIGGAISWSSKHQDIVCLSTTEAEYIALTTKYSPNGSNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIJ3</accession>
    <name>A0A2R6NIJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001211">
        <property type="protein sequence ID" value="PSR72121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIJ3"/>
    <dbReference type="OrthoDB" id="3250682at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="13912" checksum="B1CB0AE3392DF044" modified="2018-06-20" version="1">MAPSSGPRLDGAQLASIAVESVLYGVFVVLFVDSLLVLIERRRKRKDKATVLLFLTGFTLFSCMTAHWAIDLSRAFDAFIFSQDGAGPTSSQQTPADMFYSNVAAQTYVATSGLYVVIKATGDAFMASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIL7</accession>
    <name>A0A2R6NIL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIL7"/>
    <dbReference type="STRING" id="98765.A0A2R6NIL7"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="35317" checksum="611DF7EA02722A10" modified="2018-06-20" version="1">MSQSVTPYPSDPITLAIIGCGQRGKAYAEYALQGSVNFKVVAIAEPRPKTRKYFTDAHLIDQTLVFNTWQELHEASTQTLKTIGTRLADAIIIAVHDNMHLEVVLAFAEQGYHILCEKPMSTNVADCIRVEAAVKKAGIIFGIGHVLRYSPYTKAITEIIRSGSLGQFINIVHVEPAGYYHFAHSFVRGQRAREKESCFSLMIQSSHDIDILCHWLSPWTPTRVSSFGSLQHFRKASKPAAVGSATRCLECPMEHECAYSAKRIYLESVQQGITWPASTIIDGIPDIENVTAALRNGPYGQCVYESDNDVCDNQVGIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIV3</accession>
    <name>A0A2R6NIV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v11906</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001204">
        <property type="protein sequence ID" value="PSR72221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NIV3"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="12">
        <location>
            <begin position="695"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="1282"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1603"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1462"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR72221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1659" mass="187488" checksum="BC9AF880FC451BEB" modified="2018-06-20" version="1" fragment="single">ATILHPLDVDENTDELEEIPDTPLSILSELDILASSLEEIRSHSQSPSASSTTSASSSSSSDCVSRVSNMDTDRKTATLVNNGVKHPPVLTGGSLTPEVLQSFQIACRHHFNYKKVPEADKVTTVAPSLQSPVAQQWYFAHEAVLKSGSFDNFMVALRKRFLKKNWTDNIRSKLLRSSQGEDDSFDIWVESLEATNALLVGTTALFTEKRLREHIESHAFEELRILAETAEVIALADFQEFKETLSDADSKRRIDRNRRKREIEAFITSRARFTIPAAPSRTSANAAKPLISGPSAGSTANVRRAAALPKLTDGERKLLEQSKGCLKCRKLNAGHFAKNCPNGFPDAASYRDLVTGKVAIAPIAEIDTVEGDIFQIPHVGAVQGTSSAPSCVLTSDDDDWDSDMYVKSSISLPHILWKARLHSPSSILESTEMLIDTGCTTVLIRDDVVKQHALRRRPLYKPFQYRAAFGSEIRSSKEMCRLRLSTTDNSWSSKSVNAIIVPELCYPVILGLPFYTANELLIDPSNRSLLNSNGRDLLSPIPRQHHDIRTTRQKRMDNRQTEKDRKLMEQESVVLESMMEQTRHKDVIRELNLRFGLSERSFPPKEEEPPDDIVASIRQRIDELALLDILARENKQMRDTFSDIFPDDIPHINELPTDVYHRFRLKDPNAVIARRQYECPKKYREAWKTLLQQHLAAGQIRPSSSPHASPAFLIPKADRVVLPRWVNDYRKLNANTIPDVHPLPSIAEILSDCGKGQYFAKIDMTNSFFQTLVHPDDIPLTAVTTPFGLYEWTVMPQGCRNAPATHQQRMFNALRDHIGSICHVYLDDIVIWSQTLDEHRKNVATILACLRHHKLYCSPKKTDLFCLSINFLGHYISANGIEADNKKVEKILDWPIPRSASDVRAFLGLVRYISNFLPALAHHTLILNTLTTKEAEKDFSWTPAHFQAFEAVKLLVTSRECLTVIDHNNLGNNKVFVSCDASDFCTGAVLSYGETPETARPVAFESQQLSGAELNYPVHEKELLAIVRAMKKWRVDLLGVPFTVFSDHRTLENFTEQKHLSRRQARWQEFMSQYDYVITYIAGVDNAPADSMSRKPPPPCTIKSDSIGAIWAATTAMANHPPVTPILAAVSGLRISCDADWISAVKSGYEVDSWCSRLIDCLWDPIAQKDIGDEAAGVSASEALARGWLDSRSRNGVSVRLGMLYVGNRLVVPRTGTLREDVFNLAHDTLGHWGNEKSYGAIRASYYWPHMRKELEMNYVPSCETCQRNKSATSRPSGPLHPLPVPNARCDSVAMDFIGPLPEDDGFNCILTITDRLGSDLRIVPCRTDISAKDLATIFFREWYCKNGLPLEIISDRDKLFVSSFWKYLHRLTGVKLKLSTSFHPETDGASERSNRTVIQALRYHVERNQKGWARALPLVRFNHMSTVNASTGFTPFQLHCGRQPRVIPPLLHDHSSQTTEALDAAKVIERLETDVMEAQDNLLLAKTNQAYHADRARGPERVYASGDKVMLSTFHRRRDFMQRGDHRVAKFMVRWDGPYRVHRAWPESSLYELELPGHSNIFPKFHASLMKPFIPNDNIAYPSRSHEEPEPVFDPETREDQHFVDRIIDRRRRGRGWQYLIQWKGFGAEHNEWLPGAQVDNLEALDTYLKEHSLQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ09</accession>
    <name>A0A2R6NJ09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v11718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ09"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ09"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="48"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR72375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="596" mass="64916" checksum="E66485DAD5F767F8" modified="2018-06-20" version="1">MSDSEKIHDNEKKFADVGVAEFLSDSESQFVSPHESHGQLKRTLKNRHIAMISIGGVIGTGLFLGTATSLQNGGPIGLLLGYSIVGTITYAVMVSLGEMVAYLPITGGHIALAQRFVDPAFAFTMGWNYWYNWTIILPAELSAASVLINYWNQTINDAAWITICLVVVVTINMFGAGAYGECEFIFASIKVITITALIILGIVLDLGGGPSHDRIGFRYWKNPGPFAQYNGIAGVKGQFLGWWAVMTQAAFSFIGTEIVAIAAGEAKNPRRNLPKAIRRVYIRILLFYIGGVTIIGLLVPSNDPDLNLKASDAGKSPFVIAIRHAGIKSLPSVINAALLTSAWSAASSDLYTSSRALYGLARVGNAPAIFGRTSRSGLPYVALITCSLFSTLAYMGISAGSGQVFGWFANMTSIAGLMTWFGICFTYIRFHKGLKAQGFDRTKLPFHSKLQPYAAWYAMIFCLVICIFSGWAVFLKDSWDTATFVTNYLPLALFPILYTGAKLWKRVPMVQPKDMDFVSGIAEIEAECYDEPPPRNALEAFWAWLCSLRSTKSRKICGFLVHCGQTGYPPSAVGTETQVRTLAKSARETTTAFLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ97</accession>
    <name>A0A2R6NJ97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ97"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="178" mass="19448" checksum="27C78C0C66856B44" modified="2018-06-20" version="1">MPYFRRMSDDNSLDCSFGSPLCGIPLGPGPAMNVVSAKESLPEPPPRNPNVALDSYNSRMRTETTIGIVFVVCVTVVAIVLYVTLNKDVKKTIRTWITRTKTWAQRKNGKGLKEAASRQARPPHPPRNSESGMRMARDSGVAVTRPKPCALQGESRDNTLVEKSNSTVSMLPPILPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKH4</accession>
    <name>A0A2R6NKH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKH4"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26713" checksum="FEC101C6ECABB272" modified="2018-06-20" version="1">MLKQSIIPDAPLTALGRQQSAELYRSTKGTIQMTADLLVSSALRRPLSTMIIGYADLIKKLEAEGKKVIVLPQLQEVFGFVCCRNSTTLTSDQCNDLPCDTGSVSLEEALQPHEVLEADPEYAGLDFSELTPDWTSKQGFYACTVSALQARARWNRNWLRSRPERDIVVVAHGDCLRYITEGINSGSAWANAEVREFTFQVDEEHDQRGEAWLVPIKRVAKEGADEPTSSEMTDGRHVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLP1</accession>
    <name>A0A2R6NLP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001085">
        <property type="protein sequence ID" value="PSR73307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLP1"/>
    <dbReference type="STRING" id="98765.A0A2R6NLP1"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="276"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="497" mass="53220" checksum="C6130AF198CCB93A" modified="2018-06-20" version="1">MHFTPVIPPHPYDGGSSPAPDPPVIPAFSPQHAPTTPAWMNHAQAQGNFAAFPQQQFAQTPFLGVPGQAPGSYFIPPVALPQQGTPMAPVGPSGYSSDWTGFPNVALGAMGAMGGPPPGTPWGPAGGGHGQFAPQQVPGTGFAAFQQQPLPMGYAFGPWGGTPAGAFATPFAQPAAMPGGWPSHTPYHPQQAMPAMPGGGFGGAASAPAPPPSNTAATHHRPSRSTELADKIDKFSEDPIYGPVLDAFLVKVVKARIEMNPLLAPPPDKLDERPYLKWNLLFPSGQCQKSSDPGHRSWADGRGAPATWPRVKSLRLISRSIPWEIQINATDAELGVTCGDVIESIHDFMYGRVSKAQMDSATPSQKQLISTAYWHNRSTAYGVPGGRLHRTLLRCDWLGLQTMYGGIVEADERCMRDLLCGAELPCTFELKCLQRYPMTEAEIREHEAREAEVQEEEERRARRRSRANSRAASRVPSRAPSSRGNTAASTTSTSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMM6</accession>
    <name>A0A2R6NMM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10524</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMM6"/>
    <dbReference type="STRING" id="98765.A0A2R6NMM6"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="240" mass="26689" checksum="C0CADBD817BEDB34" modified="2018-06-20" version="1">MSSIDRKSLEVSEKASREDGKHEVDEEIVSIVDSSDGDEALQLVGKERTAEFSDEYNRKLRRKLDLLIPPLCAAVYFTQFLDKTSLNYARLPRMGIPDGDSYLMVLCDGLTQVFGGFVAYGISFDNGRSIAPYKIIYLLLGGLAILVGICVLIWMPDSPVHARTLTKEERIAALERVRDDQGGTENKHWKKDQIIEAVTDIRTWLIVLSTLLTSIPNGALSNFSNIIIKSFGYTLSPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMN4</accession>
    <name>A0A2R6NMN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMN4"/>
    <dbReference type="OrthoDB" id="3269202at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="191" mass="21259" checksum="EDA6A3350C165CFD" modified="2018-06-20" version="1">MPQYYVQSSTPSYHTRSRSQSHSGYPQPVVYSSSGGHHISSRDYAYGDSGKRRRNSSVGRGGQYVYPSGYSSSGHHGGHSRAPVYVTTGSSSNRRSHSSSRHAPQYVDARRTSTSGYHRRPSVSQSDGGRYHSGYHHDSEPIGDRVRRWFGLAPPHHDHYSSRGNSSRGTQYVDARTGRPVDARGRAMYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMP1</accession>
    <name>A0A2R6NMP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMP1"/>
    <dbReference type="STRING" id="98765.A0A2R6NMP1"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="722" mass="80121" checksum="89FF608526BC74C4" modified="2018-06-20" version="1">MIRNQSNDSILRSVPSKLDELVDHGFQKKDPIIIDSDDELENTTQPKECEQTTGVQRGSSNQNLACPSSLPTIHSSRRTVVPPPLEASSSRSRASIDQVEPWNFPLRTADSARLVSISMQTSTAFELKSPYRQFQTLENVPHSEKKVVDLVSESSDMDIDDDNSCLEHDSMSPTRSPSTRARLSSVISDTEAAIRRITTSPALSYMAPPEPIASPYKRSPIAIGKRRCSDSSGHNERKRPFLDPVGHSSDDDSDSDEEATASEYPEYSPPWIDSSNDIVQRLVNGTIEEVDEIIARASSDEHRNMHLLAQSVASRLSNGVATRGSSSDASSHTGSSSRRRDSATTRNLRAQNSQEARGTQIMRQASQHQPMRAGLVQNTTNVTVNLPKSDYARGRRLLVPENTSRPMAAVYMRGDMQFVHQDGRYRLSTFSLPSEGKDEGVPTRRVVDAQLLGDDTVIVAYDCGPSQISYTRLSYTEPPQRLDLQTRGHNTVFEHRRTGKSSQNPGISALAAMPQHPVRFLSGGGDGTIQLWTMSHPHPYSASIQSLGFAHSGPIRCLAYRSSDNQVFSCFHKRIHAADIKASRASDPIRLTAAAQQIHVHPQDPSIIVLEACAEVDHLDRQIQIFDTRKGSFEDTPCIEFGYRQHRGTTTVERFSKGSTQYTLFARGFGDGTVCLWDYRNAKNVSRRFQGERTDPITHTVLRGGEVIAYGSHSITFWNTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNB5</accession>
    <name>A0A2R6NNB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sodium/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v10297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001052">
        <property type="protein sequence ID" value="PSR73877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNB5"/>
    <dbReference type="STRING" id="98765.A0A2R6NNB5"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="169"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="252"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="355"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61273" checksum="B6ABC20A587D533D" modified="2018-06-20" version="1">MASAGVQHMARKASTSTSSISNEKVVDPETQVAKEVLHDEAEIDEADSRHHSYYAKLRPYILGGLALVILGWWISATIMKTTRHRWIVQTLWAWFFIIVIAWRFIPNSVATRPIAAFWIPVVQEPWFRLPYNVRLTVGWLALIGIVFGSAFGFKLTANSGYGDRAISVLGLFVFQFCFWATSAHRAHIPWPTVIVGLFAQQAIAMFVLKSGAGFSIFKWIAFLASDFLAQALQGAIFFFDADTVNTKHWFFVNTLSSIIFFIAFVQMMYYLGVMQWLIKGFAWFFFKIMNVSGAEAVVAAASPFIGQGESACLVKPYVDLMTESELHLTMTSGFSTIAGSVLSAYIGLGVPPQNLVTASVMSIPASIAISKLRLPELEEPVTRGRVVVDRGHESEKTKPANALHAFSQGALFGLVVAGQILANVLTVVSLVAAVNGLLTWIGKGFGIHTLTIQLVLRYVFYPVTFFLSVPRDEILRVSELLATKLVANEFVAYLDLQAIQHSDNPLSERAFTIASYALCGFANLGSLGIQVGVLSALAPSRGKIIARTATSAMICGFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNE5</accession>
    <name>A0A2R6NNE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNE5"/>
    <dbReference type="STRING" id="98765.A0A2R6NNE5"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="1">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="133" mass="14585" checksum="0074CFAC48883B10" modified="2018-06-20" version="1">MIGLGLLVSILIVQQGWAITVAAFRQLTDASVTPQTRITLLDALEPLLPSNHGSTTPSQIEQHTENLLSIKDLRAMRAGALMFVDLTAEVPRMLSVEDASTLEGKIARTLKQARKEIAEVRVKFHPTESDEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNS9</accession>
    <name>A0A2R6NNS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001021">
        <property type="protein sequence ID" value="PSR74070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNS9"/>
    <dbReference type="STRING" id="98765.A0A2R6NNS9"/>
    <dbReference type="OrthoDB" id="3270311at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="608" mass="67063" checksum="A43A327A3FF4CF7A" modified="2018-06-20" version="1">MAHSYQESVNTQLRVQSRATTALWGHLLQKNTPSSLLVKAPKENGLKSAPTVPIDRTGTSMRMLLHDTQAILEKFSERVDKLTNGIDDAKRDIITVQNLFQSEHETFMGEVVSLVSQCQLEVQRSVGTPVQVSQMDQFRKDLSRMDSNIDALGKRVDMLQMLNQTQTQALQTIQDQQGQLLTSLSPMLPLLQAIPLHVDVAKAEVKNHISEVRDSVSEAKHVTLRRPEPNDENIPLPELAHISPQNSSGMLPMSSLVPSRSNSLPKKRRRSDDSDGVHRLHTRLNPQSQNIPETISETLSQPCQRRRLSFHFDHSRSTTPSPGHRNSALQYFQPVLDSPKRTFLIHTMEGSNPTDLTSLDTYVPALTARVPSALTACVSPAPSRDHALPPQHIALHSAFDDAGRAQHSIAPVLSGRSCPIPGSDLCRSSDSTPASPTPNSSARVLSPDCSPIPATPEPKTAKLVLMASGHPSPSRCSMLAAEHVGSSPLRQSPLRYMQVSTYTMTQQQLLKEGSSARKGRFVPNLQDASINMVSPHVISDGTPVREPCSNGINKPMSLKDRRARGLLADSALVSIYIARYHAHTYSSIIQEKEGKRYIPFEDEDDFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPR0</accession>
    <name>A0A2R6NPR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="8">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v9849</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPR0"/>
    <dbReference type="STRING" id="98765.A0A2R6NPR0"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015302261" description="AA9 family lytic polysaccharide monooxygenase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="11">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="11">
        <location>
            <begin position="106"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR74437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="272" mass="27884" checksum="66578917AA9F9254" modified="2018-06-20" version="1">MRIPAASLVLLASAAPLVLGHGQVHSVVTSSGTYQAADAYAAVDPTSPLRKLNTYGPAADFTGPDITCGPGGNTPVANLAEVESGSLVTFNWLDWTSVHPGGDIPWGENVIRLETNVYSVHIPAGLKNGEYLLRHEILGLHVASTVMGAQFYPNCLQIQVVNGGDVALPEGIPLPGSYDPYDPGILVQLWAISPTNSNYTAPGDWANEAYGVGGTPLPTQAPPPSTPSPTATPSSAPPAKPTSTPSSAPISSAPIPSATVASVAQYGQVGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPT4</accession>
    <name>A0A2R6NPT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPT4"/>
    <dbReference type="STRING" id="98765.A0A2R6NPT4"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="306" mass="33906" checksum="F3E5FEB8D306C513" modified="2018-06-20" version="1">MEAIKELPRDIVASIGPTLAVFLPLVKAHESEISGIKHKTFKYGATERHQLDVYFPSGNFGGKAPVLFFVYGGGLMSGDRVFEPPADLFYRNVGAFFAKQGIVTVIADYRLYPHIKFPDPAEDIRDAMVWFVSNIDEVNKDVSTPADVDNIFIRGHSAGGAVAATLVLMPDLLPQDLRPRIKGLILQAGVYHFRDIVPLNPDVTSSYYGNEVQQREREPLGLVERAPENLLRGLSIITMIAEYDPPEYLAMHQDITKALNEKLGTPVQEIVMQGHNHISPNACLYSGEGEGWAFEVAEWVKVKSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPT9</accession>
    <name>A0A2R6NPT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NPT9"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="271"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="536" mass="60909" checksum="C32AFE5312145AF3" modified="2018-06-20" version="1">MPRRTTTKDAPGRLTQGSITRFFEHSSPIQPHSDPSPKPSRISRRTAAKITKKRAADTKRTRYASGEDISEQADDDDASSDVGAIHFESEVISVSSEEDDVAASPKRPTMTQKKRGKRRADSEEVVESRSESDVQEERIGVPVVWKGKAKNGKRKRPVVHSESEEETQPRRRKLVKGVRPLTPEVDDLMDEIDQDKIVESRLRKRDKRSAFQKNLEKLKKKKRGELVQSESSESDIGSGEEAVPFSHARPHEDGASEASSADDEDPELDGFIEEDNNTVAPELPVQFSMNTFQELVHHFKIICQLFVHLAVHKRNNRRNFMEQSLADDYFSVPLQIARRKITGMRDSLVTSSVWRPEFKKPLETYPDFETIQLDFALPSCDACHLGGRISTLLGRVSGDPYDKLTFQRLHDNDSSGDDEGGDSDDSGQQHVKEFHLGRFCAKRTRVFHRFTHWEYALFKALSQEVEDLQNRQSNKRMFVRVAYAGGKEPPDDLSDADGIMNWLDERGVIGMEWQKIKEMMETARSLEVAAKRGDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPZ7</accession>
    <name>A0A2R6NPZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPZ7"/>
    <dbReference type="STRING" id="98765.A0A2R6NPZ7"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7025" evidence="2">
        <location>
            <begin position="77"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="290"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="463" mass="52858" checksum="81846B3A0CA5A902" modified="2018-06-20" version="1">MKVAKVVMQAQKNVAWDANPVKFKDWQLLAFMPEFKKYSSSLRASPASDPERAEIILHLEFFIEFMELEYNDQLRELYSLQKQNRVSFRLLWGIFVPGILLISQCGQTEEPIAVRLVHVERNKPERFDTGKGPRLSLLCESTDFNAGVPTVVEKEWEIARFDGEMLLTDLPIWPMHSEANCGELRKILIERGHRYRELSKVWCHKQYSGVAMELNVNHVEDITWNPESFDYLEVEQGKKELVRALIQSHIQRSVIFDDIIAGKGIGLILNFHGPPGVGKTLTAEAMCEDKALNVIFALATEWQAIVLIDEADVFLEKRAMDDLTRNAMVAVFLRQLEYFPGILILTTNRLVSFDDAIKSRIHVSLTFANLTAKTRERLWRAFLRKAGLSENQLNAINMDLLLRLPFNGREIKNIVKTASTFASHCGRALSIEDILRVAETNIEPNVGHYSLSAWCSIIMALNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQM0</accession>
    <name>A0A2R6NQM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQM0"/>
    <dbReference type="STRING" id="98765.A0A2R6NQM0"/>
    <dbReference type="OrthoDB" id="2742096at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="64337" checksum="9A83F4BA86CABACD" modified="2018-06-20" version="1">MLDMVDSQAIKLVFERKLRVAGETLVGEIHLNVIELKKNKIQEVNVKLRGSVFTYVYAILVRLKIPSLDALPIFTPIEFALHVVTVSKLMTLKDTPKGEPVFPAPPLTPHFTQFELKRNIHVRARQWEETYKSDQVAVLGGLAPVAPSRGFYDDVQVEGVEKVWLPAAGDETKQQGSWKQEATFRSTFMLTCPPSFTSATMAVAYWMRIEVKFPGIGNNLKGEFPVQVVSSMQPPGAGTWGGPPPELDLPPQSAGWHKNVDLVCDTLSVWKRGDPEKTPETHVINVPLSFSLRENLLPSGQYGSSHGKSGCTGNVDYYVEVVGARSGAKDIQIKSSFPVLSQSSRGAELSRALHSGWQGGWRTIKELKRIRRGIWEDYANVTVSISLPDIDVFPVQSPIPFILTVLTTSKPSQQEDSSKEQAVFPVPPADPRKGIELKLLRRVAVNAGVKKQFSAGDLTVYLGGLGPEAQDDTAQIDPVERTWVPTNENPKYAGFWRQEAKFRSTFTLDCAPSFEFRTIKAYVRNTPNAVVEHLLSLSSNIQQYTMHIKVNFPGVGNDVEFQFPADLVSNRPLPPQEVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQU3</accession>
    <name>A0A2R6NQU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQU3"/>
    <dbReference type="STRING" id="98765.A0A2R6NQU3"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="238" mass="26018" checksum="63A5B47BEA40E9FA" modified="2018-06-20" version="1">MARSKELVPGVGRLSRSQVYAARGLHKGLKKSEKPTVPEVAPTKEVQVGGAKNGEKRTVPTQKAPRFYPAEDVRLPKKSHKHPTSASLRSSITPGTVLILLAGRFRGKRVVFLKQLESGLLLVTGPYKVNGVPLRRVNQAYVIATSTKVELGEFKVEDKINDAYFAKSGAKGKTSAEEEFFSEGKPKAKEAFPESKAADQKSVDSAIVAAVKKTEYLPKYLKASWGLSKGQFPHQINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS39</accession>
    <name>A0A2R6NS39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS39"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="11147" checksum="C7CC7543EDDEBC85" modified="2018-06-20" version="1">MKYRRWPWAKIKAAAGPAPLPDPEREQATNSPVMVGSTGYLELPPADCGSDIEAYPDEMRTQLDDILDYILEVRFSDAYIARLVTEIDFDCASIPKQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSA7</accession>
    <name>A0A2R6NSA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSA7"/>
    <dbReference type="STRING" id="98765.A0A2R6NSA7"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="315" mass="34808" checksum="92D887BEFAD2BF46" modified="2018-06-20" version="1">MPPRPPSKQRTKDPLAGMPEDTKAAIQKILGDYSPRANASGGSDIARHLADKDPADIEKLMAALSSMDIPEPDLDKFDYSTVPVKNKSFWVMQLTPDGFVTRDGQFVQQYTPGCQPNFQLIVYDERSSFRVSATPPQPGMPSSAFILTSFKRAIACPLPPLRQSLPSQLIIALKLSPHIDTLRPFLNSLPAPFEWRLETPEEAQEVAEGVYDRNKEGVLTGLSTAESEKTLGNQAVARKDRLKAVRHYTEAIECLQDARAQSPTEDELKKIKSLVSVCYANRAAAWLMEGTGQDPKKALEDAECAVRFDETYGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSZ6</accession>
    <name>A0A2R6NSZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v9003</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSZ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NSZ6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR75712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59117" checksum="08C11C8D0F2BE676" modified="2018-06-20" version="1">MPIYIHDISAFAILSTLCAALYAFLHGFHTLQRFAKTKLTGSLPPGPMGIPIFGCFPFLTRYPELTLDKWAKKFGPLYSMWLGNQLFVVVSEPQIVKDLVITNGAIFSSRKEMFMKSQIIFARRGITATPYDETWRKHRRLAAGFLSTKAVSNYVPGLELEVNEMIKQLYIQGKAGALPINPSPHAGRTSLNNILTIAFGTRTDSINHPLVAHWLMHSREFMNCTGPVSNMVDFVPFLRRFPDLTMVNRGKKLHRGLVETCSGLINDIERHMKNGEDVPDCMAKYLLSVKEEESLDDLDIIFICCAFMIGGVETTAAIKQWFAAHIPAYPEIQARAHAELDSVVGRDRLPTPEDEKNLPYIRAIIKEIERVHNPFWLGTPHMSTEDFNYRGTFIPKNTVVILNTWTMHNDPKRFPEPEKFNPDRYLDDHFTNAESANLADPMQRDHWMFGAGRRICPGIPLAEQEIFLAVAHMLWAFEMQQLPEEPIDLKEYDGLSGRSPVPFHIKMIPRDEHVAEVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT69</accession>
    <name>A0A2R6NT69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v8624</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT69"/>
    <dbReference type="STRING" id="98765.A0A2R6NT69"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR76201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="479" mass="54280" checksum="C9A513624DFDF06D" modified="2018-06-20" version="1">MSSVVETRKATSKVDPVTAMKGSVKEEVPADLNIPDNYVTWTLKNQKPLPPITLENVLQNIQWLTFAILTITPSIAIWGLFNVKLRWETALWSVIYYFITGLGITAGYHRLWAHRSYNASKPLQYILAAAGTGAVEGSIKWWCRGHRAHHRYTDTDLDPYNAHKGFFFSHIGWMLFKPRYKPGVADVSDLSKSEVVRWQHRWYVWLILGFGFVVPTIVAGLWGDIKGGFFYAGAARLCFVHHSTFCVNSLAHWLGEAPFDDKHTPRDHFVTALVTVGEGYHNFHHQFPMDYRNAIRWYQYDPTKWFIWVCSKFGLASHLKIFPENEVKKGQLTMQLKKLREKQDVITWAPNVDDLPIISWESFQEQSAKRPLIVIAGFIHDVASFADEHPGGRHLITKNIGRDATTAFFGGVYDHSNAAHNLLSMYRVGVLHGGIQHGLQDKLIPPAQRLRIARYNEMGGYSSTALSDAAVSDGEGMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTB8</accession>
    <name>A0A2R6NTB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000855">
        <property type="protein sequence ID" value="PSR76243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTB8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7123" checksum="3B9B0A0F53F229E1" modified="2018-06-20" version="1">MSRQELLGEAEDDIDENADMAKRFEEDNLGDGPSRRALSGLPQNGHMDSIGQYLGRGSGQTLLDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU27</accession>
    <name>A0A2R6NU27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU27"/>
    <dbReference type="STRING" id="98765.A0A2R6NU27"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR76691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="287" mass="32676" checksum="EE7F07B391361F49" modified="2018-06-20" version="1">MSNLPAFLEPLQQTLPGQPSTEPVHYVNALFRHKRFPSLAHVLYWPSKGESKTCMVFIPGNPGLLDFYTPFLAGIHEKAHDKMHILAHAFVGHTPGIIRGSEHPAATSLDAQIEHVIELIDTIKPVYNKIIAIGHSVGTWVVLQWAFKLPRMISYASVFTRLMPLKMLSVLFPEWPEAQLRVLRSFLDSPSAIYSSLSMADDEMKQIQDLDGAALQQYHHRLHMYFAEKDDWVHDHKTEILDVLQPDPGSVRYIHGPEDIPHAFCINHGEELAEQCYRWLVEGDFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU38</accession>
    <name>A0A2R6NU38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heparinase II/III-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU38"/>
    <dbReference type="STRING" id="98765.A0A2R6NU38"/>
    <dbReference type="OrthoDB" id="3476529at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="4">
        <location>
            <begin position="538"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR76679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="805" mass="87945" checksum="9BB63FC61908CCD6" modified="2018-06-20" version="1">MAANYHNANATNSPYGSGDPYYNESSGYITPMPMKKRTSNWVKFGIPVALAIVVAVVVGAVVGSKHSSSKTASASGSASDSSPSGQAAAASSAASVKNAIGIYPTGTDSQYLLPLYPSTVSFLYLNRGRVLNILTTNQTNAAAFTSPTFHPTTDASLAWPQDPFQPSNPSPTSLRPDRPRLIAPSYKWQVLPQLIANDVYLKSWNETIFGNATEYYSLPPVQYFMDGSSGILDNCRYVKERVKAFAYVYRMTNDTKWVDRTVQELDNAAGPNFGPNNSTKWNPSHFLDTAEMTAAFAIAYDWLYDILSPSQKTTIMTNMITYGLSQGIHGYENANGGDWSGWWAADNIQGNWNCVCNSGLTLGALAILGDDTTGTAEQILSLSIPNAVRNCVNAVSTDGTWTETANYWYFGTTGHAEMASSLMTAAGSDFNMLVGSNFDLTGLYHMYVSGFGSLFNYGDHGPNKYSTTANPMLLYGDYFQHPEYVLFQRDQHDAPEPWSMFWYNPTVSGAFWDGMPLDHFFDNSTDQWASMRSTWTDETGMYVAIKAGELLGHQTHNDLDCGDFVLDALGTRWAGELGSGDYNSPDYFTSDSQDAVRWLYYRKRTEGQNTILVNQQNQNVVQAQPTVNHGTTGEVQGSSTVYNVPNSSTAFWTADLTTAYNDTTSFKRGIRMLNGRKQVLLQDDITASQPIMWRMHTNATVSVDSSGSSATLTIDDKTLNMQVLNPTTGINLVIGDAVRFANDPPLPAGAVDSPNPNVTVISISLDPGTYSLQVLFNPQWPGMATSDFVTPPSVAIDSWTVTSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWU0</accession>
    <name>A0A2R6NWU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000740">
        <property type="protein sequence ID" value="PSR78466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWU0"/>
    <dbReference type="STRING" id="98765.A0A2R6NWU0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="70856" checksum="645D95F5AFCEA542" modified="2018-06-20" version="1">MFDFLHKIRHPRLSKLGLVTKWRASRRHQVSATHLSTDISTQIPLLFLPFPEDTAGVLPVGFREASPTLEIVDILYEILHALRKTDLFHCAQVNHLWRTVAHDVAWRSSSSGGVGVRQLLSVLDEYSEKYSTPRFSVTLMPRSWNVLRRDYAPLICSLTLDLAHLSCSRWFLETISDTLTSPVHLPNLGKLHIILEQDPVQLSVVKQFFACTVRDLTVEVLSTNVTRRPLHVHTAGLIPVFWDPTISPDNNRSTEATLVLMSLFDAIREWMVGIAALQINIRGSHDMVLSWHPFVQMLLSLASLRSISLPGYALSRLLLAILSSHAQLRRVAIVKPRVDQRIAIDLEDASDALFTIPVYDLDGPSSSLEELALTVPIPEFTPYFTIHFDPYALTTLHLLFPGEVSERNSVKHAFLLIANQCPHLVDLRVLILQPEEHPWRIDYELLQPFRRYRTLASLDITSRFTTDLKEDEFIRLVSSWPMLKHLSLEGRDATPVHHAEKASLSLGTVVDVFAEHCPFITSFVFYTSMTLQAQSHPTYHSATARTRFASLEAGTLLIGFPITATAAEVAVYLQQSFTKLRLSKLTYQPVVRQTVSEGDLPLSWRMRRETLAKFAHEVASNLAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX65</accession>
    <name>A0A2R6NX65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000743">
        <property type="protein sequence ID" value="PSR78424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX65"/>
    <dbReference type="STRING" id="98765.A0A2R6NX65"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16765" checksum="21621AA648658B59" modified="2018-06-20" version="1">MSTIRVALFVCDVPLAAVVEKDGDYPVIFNELLRQSLSLADSSASFILDSYDVREKMEYPKDIDEYQGIIMTGSAASAYENLEWINQLVAYIASLAEEKPHIKLIGTSTSPSHQPICATNPIYFSRDMFWTSNPWSRPRQRLRTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXA0</accession>
    <name>A0A2R6NXA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXA0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="9853" checksum="6825AE2E293670D9" modified="2018-06-20" version="1">MSYVLIAETDTDLTLTPDDPIATTITTSVGEILYQVLTGTQGGGRVTQVRNACNEVIGSLGWGAGVPDKVLVGNSRKPISMPSWMKKSAIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXE6</accession>
    <name>A0A2R6NXE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXE6"/>
    <dbReference type="OrthoDB" id="3149405at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="280" mass="32073" checksum="64DDBB8F2795F3CA" modified="2018-06-20" version="1">MHTSRQAWDDACTKDLEDTWKIYARLPSMATVIPTGAAAQLINSDETFLYMLEETRMICGLQQDLAKWASRRFAEDGFERRWKALAAGDRKNVILEGLYRTMCLPDMDDRRNFCPDSTSEYLTSQNGDAFLRMLKEFLPAGRNAVISEPIHIPHPIVDRLLTLSPADEAKPGLKVAIQLHRSQRTYCLTTIVWNTCLAFVRSESNTLVYGAFKFSVLVRRERNSNVCEDTKGTPRRPAEPAGTKCRQISQCSSERLRLCMLEMWYIGEESRTWTQITSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXK7</accession>
    <name>A0A2R6NXK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000697">
        <property type="protein sequence ID" value="PSR79379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXK7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="10264" checksum="BF18C0804F672A35" modified="2018-06-20" version="1">MEAGQHEIGKVLDGSNKADDQPMKSEPTILEKFKEKEFKVLEWDGINAMVEDEGAPSSEVSERTAEQEKAHHEMRKEAQVKLQRIQESLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY95</accession>
    <name>A0A2R6NY95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY95"/>
    <dbReference type="OrthoDB" id="2803755at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015317752" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29514" checksum="924B414E96CF537B" modified="2018-06-20" version="1">MSKMLLAGVVSLLAASTSVLALDNVVAVDLQSDVLYLPSALDWQSTVDSPCGTPDYFTSVVNSTLIVSFIGNEVVVDGMQNNASGLLMVVIDDEEPFIKDLFSEDVTCGNFFTYELGNGTHAMSLTLRGASVTGDEGNTTQPVLHLTSITYSIPLADDAAISTSRKVKVGAIVGAVVSSVVGVILLGGVIFLYRRRTKGRHAFDPRANSIVSATEMSPRSPTTPKTATKLQPYARMEDDYDVKTPHLDVLPPRYTPSSGGLRARSRSPMPDRKAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYG3</accession>
    <name>A0A2R6NYG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000664">
        <property type="protein sequence ID" value="PSR80187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYG3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="155" mass="17180" checksum="1C27A96F2DCA629C" modified="2018-06-20" version="1">MPTLTVHITGNPTAVNQYSVELHCAPPTSPTGIKDVDKTGPTSESPTLQGARNSDISGHVTIDKSDTMLIDSPRVKKRRRGPETEPPAGSSTIGPEHLLHLQLARAEEKNRRFELEQYHFQEIVLERMKDLDTQLRIVKQVVQMFAISDSGSVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYH9</accession>
    <name>A0A2R6NYH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000661">
        <property type="protein sequence ID" value="PSR80238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYH9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="393" mass="43296" checksum="8A819A4E744724DC" modified="2018-06-20" version="1">MSSSSMKAYSRLTDNYALVHLRLDEIKGPNAGAAQDVGSIVDIVTDANWQAQIVQARQVFVSHAVDSIVRLMKEPEAVIKLTDAEKAAIAGEADLVSLWTAVETAWKGYVGCFETKAKDYRVQKNQMKPVAKHCKQISDQETVAERERETIGAFDAFAKRTQARRKVVLNEKRVKFGAVSKVALAGTVQQRTEVQRKLETGASSVLVGALESWMALPDVESCYLRDEVPAMPSIVNDSPEVWASWRKTVDGVCQQSAYAWGTEDDEMGQETTEGVDNANAVMMRLEGLTGTTEGHLEESGGSVVIEAGHDTETGPLSCLLTDDTVEEVDESTEGNIITGVTCDEMQQALFLYIVGPVLENREAQATRVQNHLHMPLDVQNKNWRNLSQLNRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYK8</accession>
    <name>A0A2R6NYK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYK8"/>
    <dbReference type="STRING" id="98765.A0A2R6NYK8"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR80371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="488" mass="54888" checksum="956DC174FE042582" modified="2018-06-20" version="1">MALPTRGRVIIDTTVGEIDVELWSKVRCRLFLYEEKIKHSLQHIKGNTKDMSEFPHPGDGRVVPNFLVQTGDKTGTGGGGESIYGEPFEDEIHPRLRFAHRGIIAMANNGTKNSNDSQFIITLDRADELHGKHTLFGRVIGDTIYNVLKIGGMEIDANERPLYPPKIKTIRIVDNPFDDIIPRITAAEKRAQLRAREQGQREREEEQRRRGAKKDVKLLSFGADEDGEEEEQVIFKKKPIVRPDLVENPEPSAAIPVAISQASKEKHSHRTTEAASKIVEPEKIRESTKVNETDITKIREKHAKEQAAQSSSRQTEIEKMEAEIRKLSRKARGDDSDDEPTKKKAKKSYLEEEMAKYAKAKGAHKKAKDGKRKDEGDVLAALSSFRSKLKGSAPDRDVPIEEPTEDQEALAGASTVGAEEDPGMEVDDDTGFLGHALHFPKDNNEEAIKAERDYEVIDPRQRGARAKEEERERKRALKPKDGGRGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P003</accession>
    <name>A0A2R6P003_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v6500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P003"/>
    <dbReference type="STRING" id="98765.A0A2R6P003"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="136"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="393"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="686"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="846"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="874"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="921"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="954"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSR81165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="980" mass="108429" checksum="115C157C52724CB4" modified="2018-06-20" version="1">MPSHSTLFKRKRPAESDDEDDEFSIASRDDSDDEIDISSALTRKRPRQDSNKMRKGAHDDEDEDELQDIIRDSISKRDVKGGTELLKKTKGKSKISKGEVGGGSFQSMGLHPWLLRSLTLQGFRIPTPIQRLAIPSLLSNPPRDLVGMARTGSGKSLAFLVPLVQRLGGRHSSAFGARALILLPARELALQVLKVGKELGRGWHAGEGGDHAGDGKINEDSKKGQNLRWGLIVGGESLDEQFEMISNNPDVIIATPGRLLHLIVEMSLDLKSVQYVVFDEADRLFEMGFETALTEILHRLPASRQTLLFSATLPKSLVEFARAGLENPKLVRLDAESKISSDLRMAFFSVKQIEKDACLLILLRDIIGVPLGNPLQRDDETTDRKGKGKARSKYSDRITAPHQTLVFAATKHHVEYLTNLLTTTGYAVSHIYGSLDQVARSQQMEAFRRGHTNILVVTDVAARGIDIPILENVVNYDFPQGARVFIHRVGRTARAGRQGWAWSFVTHTELPYLLDLQLFLGRPIKHEITGNGDQVYTESLVIGPFDRDRIDEEVEYARRLDEENSSLPTLRELMRKGHSMYERSKGKASPASYHRAKVMMKGGKSGLVGSTSSPHPIFFRSKDGSSMVKKLEEEKKRKEILLAVSSFRPTETVLEIGARGNAETAALMKQRRKALSKAAERAQLASTSAAAAIDEVPEDPNDEDEDGKEVEMANEEEIAAVFDSSTKPHEKGRTGSHRDSEYYMSHYQKDANTEKGYSLRDGATFAEQARDVTFDLAGDDGKQERKRRELRWDKSKKKFIMGTGEGADNVKMVKTESGTKLPATYRSGRFDEWKAQNRVSLPRVGEEEAPVAYRRTPTGAGGRKWKHNQTEAPKPLDKLDKNYERKARQQKKQGDREAEPASGAKGKKLGGRFGGKPLGKVKNELKTVDQIRKTRQAAEQKKAKNARPTHGKGGRGGGRGGGRGGGRGGGRGGGRGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P009</accession>
    <name>A0A2R6P009_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P009"/>
    <dbReference type="STRING" id="98765.A0A2R6P009"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="217" mass="24378" checksum="45A6E2643C08A540" modified="2018-06-20" version="1">MPEWKFALQRRSPYGSAQERLRPSGLQTALSRLADISSGPEIQLPLVVTPFAHFVLAHAILRKLFEDCVEKRPMDPQQEGFSIQFMLHNWLQSWMNSPDTPRYAEGEPIFLHDALPFYWIAQVTLLAYQENLPPFATSSGAPGASALGEAKFRLVKEWLKHIREFLCKGEQGPTLFWDELTKIRMKNADLAREASLASGSVASDDSRGLLGFFAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0I7</accession>
    <name>A0A2R6P0I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000583">
        <property type="protein sequence ID" value="PSR82477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0I7"/>
    <dbReference type="OrthoDB" id="2757832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="115" mass="12485" checksum="593AEA8785F6D620" modified="2018-06-20" version="1" fragment="single">IQCMHSRGPIYISRTQSADVWLDDGAHDITYSDGWDTSPNGFETEYYRNTMHRTNVNGASATLLFSGNAITVYGATSTDYGLFSVSLDGSDPPLVLNGSAPVFRAQNMLVSVLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P103</accession>
    <name>A0A2R6P103_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P103"/>
    <dbReference type="STRING" id="98765.A0A2R6P103"/>
    <dbReference type="OrthoDB" id="2798026at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="293" mass="32411" checksum="9B1C1C4C0B289F99" modified="2018-06-20" version="1">MSARKRKFSSEILPVFQSIQGQKQTPSFPRYTHILIHIKPILSEGKRSVWSSLIADLYKVAALAESITQQRPRTNKDWLPVADTLDREGVNLWNVSGPIRGGADDASREVVAALRYAGFRLIEAGLEQKQFVETLIHVLQLASKAAASLSEIGRHDVAANILACAAKYEEQLRTAEDTLDIHQQAKAQAVTLYYSSRMEAAWREGNDGVADFMLQKITDNDQRLPLLLPRDRESLASKLLEIGKAVLKSAHQTEPGAARGKYQTAVKWIQKAFAVIEQSEDVGAAPTLGNLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P137</accession>
    <name>A0A2R6P137_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P137"/>
    <dbReference type="STRING" id="98765.A0A2R6P137"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="363"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="651" mass="72372" checksum="E93ACFD94687BA9B" modified="2018-06-20" version="1">MKRLSAKFFKSPSAKLVQSSPLADPPSMPITHTTGLQPKFTVPPLPHPCPHEHISVLATSQGLLLRPHLKNGHSESHVRILWGKEAKVEEIHNDGESEEADWSESVIVYGLIGVLNLFTASHLLVVSSRSDVGYLFDPRQTVYSVKGVTVIPLIESRARDALNILRVRNHTSQRHSLIPGATGRGSLEDNTLDSINNVDERSGGFSSHRVKFAAEDQVKVMSPLPPHLKEESEGDRDRSPSPSPSVVSTPSSEFSDHTTNLTKTLADKLSFWNRLSKRDSQLQSGSVGDALTRKNGFGRESSSQGRGSGEERISLDDILENGVREPGDVLNTILATAPPPQTAEQKNSELEDKIIRECVSQFTRGGMYFAYTFDITRSLQHKQELIAKAKKQNALLADLNALDDSAPLNAGEGKVNVMGEASATLPLWRRVDRQYWWNEWLSKPFVDAGLHTYVLPVMQGFFQIASFGIPREPEETEEGDAAVVDYVLVSRRSRDRAGLRYQRRGIDDDANVANFVETETIMRVEREGFQNVFSHVQIRGSIPLFWSQAGYSLKPAPALSADRSHAQNLDALRRHVQRTLPQYGPLTIVNLAEQHGKEGAVTTAYSGSVHELGLKDVQYIAYDFHNETKGMKYENISKLIEQMQRTFESQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1J3</accession>
    <name>A0A2R6P1J3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v5724</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1J3"/>
    <dbReference type="STRING" id="98765.A0A2R6P1J3"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="26"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSR83452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="39524" checksum="4CD9B926EB4BC92B" modified="2018-06-20" version="1">MPLSQDPMRYYRSKRDQQRPRVTDKYTILGFISSGTYGRVYKARSKEGDGRIHAIKKFKPDKEGDVITYTGISQSAIREIALNREISHENVVELKEVILEDKSIYMVFEYAEHDFLQVIHHHSQTLRSSISAPVLKSLSYQLLNGLLYLHDAHIIHRDLKPANILITSNGIVKIGDLGLARLTYQPLQPLFAGDKVVVTIWYRAPELLLGAKHYNKSVDMWAIGCVVAELASLRPIFKGEEAKLDSKKNVPFQKDQFLKIIDILGTPEEREWPGVKDMPEYLNMKRLDRNDNKLYSWCSKTNFAHGHEFLKQTFAYDPDKRLTARDALRHKWFQEDPKPTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P220</accession>
    <name>A0A2R6P220_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000546">
        <property type="protein sequence ID" value="PSR84003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P220"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR84003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5824" checksum="9CA47FBB03ED6BD4" modified="2018-06-20" version="1">MKVVLSVLLEAFEFSPSDKDVKWNMSNVSYPSVAPSDTKPAMPLRVKAIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P236</accession>
    <name>A0A2R6P236_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000549">
        <property type="protein sequence ID" value="PSR83947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P236"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="173" mass="18963" checksum="011BA08F2B557C39" modified="2018-06-20" version="1">MLPILVENNNIASLVLHKIRWDSSIPSASINSLQRREQLLCLRILLPAMTKLTAKDSLSQEDTGKAIPVNSPTAARSTQREPWVGSCDALYLCANLSPDAVLYNPYPVPETTNVVMCGDGRSAYTLNSFFEIFVLKRGWSVVSDRGRQNNKVSAKPGHRPGSDNTPGCSCVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8J1</accession>
    <name>A0A2R6P8J1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000519">
        <property type="protein sequence ID" value="PSR87072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8J1"/>
    <dbReference type="OrthoDB" id="3269308at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="334" mass="36876" checksum="393D919BFD397B54" modified="2018-06-20" version="1">MAPSTSKKRENHSATRTNPEAKRPRTERDVDISEQTTDTSDKYVLPFPATLTKLSSSHSSETAASMADADHLVVASDDRVSGTTPAVPSPSTVEGVNTTISVGTRSFFDQRLVDRLNTMNAYRNPASCCYSIQTLPIEDTVWGNVGYGPDDNSEYLYLGGQRVLVRFVAEVIFNNFVELKTRNPTRRAGVKFRPLLECDFDKASSPSASGDADVPHALWASRWMNDYGQPDDDLKLFERSFDATETFQSKLSMDKYPADQIKPGNVALVETAVTRWAVKDDAAVADSPSSPSKGKKSKRKEWKNWNVHFRIDAISIIHQGEGLNEGGAGEDVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8L5</accession>
    <name>A0A2R6P8L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000517">
        <property type="protein sequence ID" value="PSR87140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8L5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="36326" checksum="18DA0CCE43E08837" modified="2018-06-20" version="1">MSRHDGKALERFVSVVVAITQTAQTFPSAVEMISGLYIYEPSRAWPYNGNPRVLIRTVQALCSLLPNLRSLELMDVMLDSKGSPSQSPVKLFTLDRLVLKLDILEVSSEILTILRLFSQVGSLKIHCHFGTRVKDFPFAPTGSPVSRTLLASADEFTNSVQRGRGLEVAALSLNMDTHGGFYLGLLKKTGLSETVEDLTVYCRTKDDVESLGAFLANDSGCDTLHRLSVDLNLTVEDITFGFRVPGDRSAVLGLLEDNLDWVDFERSLAKWSGLREIVTQVTVQRTVLAADGVSELEADIRRLFRRNLPSLDSQEFLKTRVEGAFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC28</accession>
    <name>A0A2R6PC28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v5003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC28"/>
    <dbReference type="STRING" id="98765.A0A2R6PC28"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="463"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="751" mass="80974" checksum="39F2E97BCF59F96F" modified="2018-06-20" version="1">MPPQSGQDFTLSSVLHFLQTEWRRYERDRNEWEIERAEMRVRNLALLEGERRSFDNVKLDLMRRIKMLEYALRVERSKQLSQTTSQGVPPAKLASIQSHMGGSSQKDDGSSGSSPRSEDSPLPPEGPMPLTNGTGPTRKTQTWSTGSNWPLQNGPSAASIGALGKPPPGRDPKSRARSRDYLKQCLQEISYLTSPQAMNPLPNRPLLNNSSLPLTLPNVPSFDQMAFNGRPRKVMPEVGKDFPILNGMSSLMSGPPSAPASTASQGSPLDRAGILGSALLQSQQPATGGPLGPQVQLQPQQPAQAGQPQGEGKEGEGDNQPTQLTAIFRPDDAGEWKERLRLSHEASEQARASQADESTLSGAASWERRSREEEEEKSEEDTEVDEEEGTEIGDSQGGKVWKPKRTLRNHLDAVRAVAFHPTELCLATGGDDNTVKIWRVDLAGLAASASGRPATDVEPQLTLRGHSAAITRLVHAPSKRLLYSASLDSSIRVWALPTSSHTTYAPYDATRARGELIGHTDAVWDLALVRDESTLISCGAEGSVKVWDVSGPSGGGSLRLSWSYDGMDAPADGELGVENGDAPGATAVEAIKTDLKKVAVAYQNAVIKIFEIENGKEIMKLQCDISQDGAPVGQVNSIVSHPTIPLLVTGHEDKYIRIYDIVTGQCTHSMMAHLDGVTSVSLDAAGFSLVSASHDCSVRFWDILASRACVQESTSHREKANEGVLAVEFHPNLPVMASAGADGVVKLYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG07</accession>
    <name>A0A2R6PG07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000495">
        <property type="protein sequence ID" value="PSR90487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG07"/>
    <dbReference type="STRING" id="98765.A0A2R6PG07"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="525" mass="59926" checksum="2454CE2152305B36" modified="2018-06-20" version="1">MAKGRKVSSTRRPKVQSDKLTLPGWEGQGSISVAERIEHIFVLIQDALEANLEHRWYAVYDWALNFNALRRGSTQHRLSVYPQAKLVLDPSKGIVIGYDEAEFKNNDHSNEAGQERDDPAPASGPANQEDYQGVEEALRRVSITASELQQVVENSASETKEEDNEDNEDEDDDNDEDDEDDEDNEDNEVDEDNEHNEVDEDNEDNNEDDNEDDNEGNEDDNEDNKEDNEDDNKDNKDNKDNKDDNEDNDEDDNEDNEDNEDNEDNEDNEDNDEDGGDDDNEHEDTLPQRSTRKKKNPRASIRPPDSNVSSVPSEVEKNIIRYPDFSISITLPQAIGIHSLWELKNFPVAIFLGVSEARRLHWLKERFRSMKRQILQQGACAFSEFPLQKTLRVFCVLGYFLTCVVLKRSNMPEVDFNYAEATREEINRFIPNKSTRIFHLFNAKEEDYSRVFKRTWTRAMSCAMQEIGKSSAGSTTQARPKPTLYGVPLGPLPANTEGKNSKRKERPKRANSAVATDSMNGYTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG25</accession>
    <name>A0A2R6PG25_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v4875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG25"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015337044" description="chitinase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="22"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR90582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="33783" checksum="DD6CE2E082FBA60A" modified="2018-06-20" version="1">MVSLLFSRIVSTAVLFVISHLAGVLAAPSGWDGLNNQARDILARATPAAPHFVVYGDQYVSGTTGPPALSFLLLEGAWDKAEEWTTLTASERTTVKSQYAAAGISLVVSVFGSTDVPTTTGADPIGTANTMAAWVKQYDLDGIDVDYEDFGAFDSGTGSAENWLISFTQQLRTQLPVGQYILTHAPVAPWFSPNYWGGGGYLKVHNTVGSLIDWYNVQFYNQGTSEYTTCSGLLTASSSTWPQTALFQIAASGVPSSKLVIGKPATSSDATNGYMSTSTLASCVSQAKSQGWNGGVMVWEFPGAAASWISAVRASSWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG37</accession>
    <name>A0A2R6PG37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG37"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7845" checksum="4F73F9B8B60498C5" modified="2018-06-20" version="1">MKFSQPQLTTIALAVRDGLLIFLNRFRCHEDIPAIYGRSVRHEYGTVRQLAPLPVGDCIETFHSFRNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG56</accession>
    <name>A0A2R6PG56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v4887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG56"/>
    <dbReference type="STRING" id="98765.A0A2R6PG56"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001070">
        <property type="entry name" value="Dynein intermediate chain, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="487"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR90594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="667" mass="73824" checksum="B073F824F51CF66C" modified="2018-06-20" version="1">MAEARGRRAELEAKKAKLAELKRAKAERNSRTPYSTSVGPSTNPQEIDSFVTSLLGPPGSSRRGIDIDSPSSSIPGTPLSQSTTPIPGPSSLSASGRLSRQSDALPDRVNMGTAAVQSSNGGTDQLTYREIAPRSMPDLIDVEQELFELPQKERVIYNKEVQTMDLDEDTDGDQAEEETRQRVIREREAAEAERAARDKELEEESVQLDKEIEQEIREMTEEERSSIFAIPEFLDFVEHSTKIIQRALNDNYDYVRDYTIGTETGVDDSEGRRVKQICAFYDERYGKNRSITDVDWSPKYPELSCAAYNKNPAALNEPDGIVAVWNMHLLERPEFVFHSQSDVLSVTFSPFHSNLIFGGTYSGQILLWDTRSKHLPVLKTPLSAAGHTHPVYAMQMVGTQNAHNLITSSTDGTVCSWLVDMLAQPQETLELVHAGHNKTGEVAITTLNFPDNETTTFWVGTEEGNVYQANRYDRAGAKAGLNQYDVYRGHSGPVMGLHFHPLLGPVDFSDLFLTCSVDWTVKLWRAKSLSKPSTTANVIPPIYSFDEADDYVYDVKWHPAHPAVFGTVDGSGKFDLWNLNSDTEVPVVSTTVGQGRAINKLQWDHKDGRRAAMGGSDGKLYIYDIGDMALPRESEWADLQRTVAGIAGGAQTNGLAEGDGSRPVNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG59</accession>
    <name>A0A2R6PG59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG59"/>
    <dbReference type="STRING" id="98765.A0A2R6PG59"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="404"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR90679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116852" checksum="36AD0E15EF771DF0" modified="2018-06-20" version="1">MGSRFADIYASQLYHHGEGHPLWSPEPSKFGEVEIGDVGFIQDGAFFRLFNVTVAKDHPLNEHGVPDDFVKLELNSLLHNVIDHHLDEGPLSSRSVTTTSIRVGAGAEGGPNAGAIVSYEFQCTEEQGAMLILKDTARKEIMFNNNTWKKYIRVYHASWVRYARDVRDHDLQPEDIILVRGWTKTTKWTVAAFSASQTGRVVSAKGRIDPFASAGCELSFIGKTIMPARSRSGPRRSAVSCTQLPECATSGIGGISGPDKFDQCVFLFYWKTKHRRFIPMRIYAAGEDDELYEDEDEEDHGSLTFDIEDESACKTDNVPPLPAPDPLSCVLDYILENSNAEVAIVKEDDAMEILNGEGYPADFSAYLKHKKPCVSVDENTRTGTLSSNDQGSMSITEWAAYGQNTLMISSFDCVMTSEKVINALARYGPIANLRLVSGKGYGIVNFVNEADAILAKDDICSSSGSSIASSCGGIIDVCLGYTFVARLQAVSRGALVRQRYEWPLRRTIQRDRMDIERVRTHEKRLFNAETLSSLIAQQAKHITMLRSLLQNGKKPRDSATSATPSLCYSKTATSSPDVIDADMLDSVIDYAGISPREIPNFAHWEGMEAFKAGALPAADEMKYMTDDLVLGTVDSATGTDSGIDSESESEDPLLSEDQGPVKIIKKVRFSKINAAAAPTSPQPTIIDKDGYELARTWGGFQLDVSVERPLVERCYLPAVGTIGIISPTEAENLFDIYWNYINPSVNLLDPALYSVQNTHWRSTFLFTVVCAIASRFYLERPQLSRQLRSSAEQAAATALISGKSVDDVYAFMLLSMYPVPVRKWEDDKSWIYLGVAIQLATNLNLEHPTMAVSKNEKLARETLNRTRAWLNCFNLDRSIGSQYGKPPIISNTDYVAHQAETWWNKSSYNLLDLDIHLAGQTACLTVLAHFRACIYGNPRNPTGYNKCLCAAFHTLGDVLEDIGSPDKRIFFKYAPEACSVYPTFACAFIIKPRYSAFITSALRIEICDKVKQIIELFECEEIAIDEHHWPKLYANFLRGLLPDPMVGGLESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGD8</accession>
    <name>A0A2R6PGD8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGD8"/>
    <dbReference type="STRING" id="98765.A0A2R6PGD8"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="181" mass="20772" checksum="DFB9BA1F0B358C3A" modified="2018-06-20" version="1">MRPFDTPDTVLLECYYTDSILKFRLTFPPNYPERPPVVQFLTDVFHPLISQQDGTFNLAPRFRPWKPTDHHVFDVLHWIKAAFKKHALDDIKEFDCLNKEAFRYHDTTSSFAALATQSSMLSQSASALFDKDHPSMAGKGSHSMLFRELKPEHLSSLRKQLGLSEWVDSAEMREGKPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJA0</accession>
    <name>A0A2R6PJA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v4755</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJA0"/>
    <dbReference type="STRING" id="98765.A0A2R6PJA0"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2360:FF:000001">
        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="874"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="827"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR92225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1019" mass="102365" checksum="326C9A2F5B02FB30" modified="2018-06-20" version="1">MFGQNSITSSWGQPQQNQQQPQASSAFGQPAATTGFGAGNAFGSGGAFGQQPQQQQQQQPQANPMFGGLGGTPNTTTPAPAAGFGAFGATNTASAGSGLFGAPKPATGFGAFGGGGTSTFGGGGAFGGNTAGPSTAGSGLFGAQQSSSTGAFGGGGGLFGGAKPATGFGTTPTAANPNAGPYDTVAPVTTGTSNPVYSVFNEKDPANSNTTLQYQSISCMPSYRGCSFEELRFQDYQQGRKTAGAFGQTTFGAPATQPTTGTGLFGQPAAPTTTQPTNSMFGSFGNTNTANTSTGTGAFGAFGQPAGGAQPANTGAGIFGGGGAFGQQQQQQPPQQQQQQQQSNAFGAFGQPAQQANTTGTGLFGGGGAFGQNQPKPFGTFGSTGTGTAGTTGAFGSGTGAFGQANTQQNGTPGAGLFGQQPQQQPQQSNGGFGAFGQNVVKPSIFGTQPTQPTTTGFGSFGTQQNQTGQQQSAQPAGSLFGGGGGGGGGLFGQNQQNQQPGQQQQSGGLFGTQPAATGTGPFGGASNTGTSLFGANNANQQQGQQGQQSNAFGLFGGPKPATPAAPAGGGIFGGFGQTNPNNTTNAQPGAGLFGGGLGQSTSNQQGNAFGGGGLFNKPVTPLGGQGAQTAGTGFGGNSLFGSMLGANNAMGQSTSLPSLTASIAQPIGANIPLFNMLPPGPRAVNLDQPKKKAGLFVDVPTRSPVPRLQLGYTPASSKLRGFTSTATIPGAHGQSLGPAVSLTSGRPGMLSISKAASSKSLLGPDAFLHGGGPSPGLGSGSRQSVKKLVLDKKIDPSDLFGKSNAKITFNPALSIAARELEAAAASSSDTGFVTPTPPSKTHPPKAASRFSAPGADEISKEKETAEKELELRDGDYYSHPSIADLKKRSFKELAEVEGLVVGRVGYGEIEFLEKVDLTGLSKTADLLGNFVRFDDKECAVYPDCDEADKPPPGSGLNVPARITLLHCWPLDKATREPIKDEKHPAAVKHLKRLKGMKNTIYEDFVLEKGKWTFTVDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMV4</accession>
    <name>A0A2R6PMV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spermidine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMV4"/>
    <dbReference type="STRING" id="98765.A0A2R6PMV4"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR93723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="75847" checksum="685A3609662744DA" modified="2018-06-20" version="1">MSTPGARGPLVSATVNTISIALLLSLSLITFGYQRALLPLYGSAATEHHLNKIVWLVCIVGTFMPALPAWPSLLLGGVLLCGMPQTAYWVAVYTGQMGDVIWGPVITHLSVLAPVLLLGVAVVKVLQTENDTAAMMGAPVQAITLPVCRMAIMTLQELWPLVPFIQETSETDIFTYLGCGTIALWALSPLIPSFPQVVPTPSNPSAQPKRRPQSSTSKDYWRLAVLPLVPYLLNNIQSPTLPKPLLEPFIHPTAPMQILSSVRSPYSGVILVGEVLPPTPEELEVGNIIEPRSLRYLRAGHSLLGGVWIGDRVYRKDGLGPLAFDQDLTPLGDSIYSAFVTQEAVRLVIMEEESVQQNALIIGLGTGISASALIQHNISTTIVEIDPAVYEAATRYFGLVVPEPEKVFLTDARGWVISKTHTETQGVSDITDTRPTPTFDIVIHDCFSGGGVPSHLFTQPFWEDLRKLVKPDGVVAVNFAGKLASDSSRAVILTLKQVFSQCRAFHDSMKGLSEEELKTEFVNWVFFCTPSAKPLAFRAATESDYLNSYLRERVLSTLPEHEINLDLVIGDLNENDQRKYVLTDERNPLGNWQAQEALHHWKLMRESTLIFIPVFRKRTCTASIVLDVGNVRIRPQYCAVSLHRPSRRAVRWIPPFVGDRIADVLLHFSHLRTSTALDALTWHPTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNA0</accession>
    <name>A0A2R6PNA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNA0"/>
    <dbReference type="STRING" id="98765.A0A2R6PNA0"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="181"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR93807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="47769" checksum="6BE08112A24318CD" modified="2018-06-20" version="1">MSVPDAISVFAEGTFEEQIKELVNYLSHGRSDEEKAALIQSFETLLLPQEGQKPIDEDEERRKKVVTMVVDQTQGLGDGTEREIEGYFNLLFAHILSAFSSDASETKDHLNTLLQTITSSPESSSIKYRILSNLFNAIPRSSSLRLKVNKTLVEVASENDELNHLHLSVSEVEKWLSEWQVTSEEKTAYLKTLVDVFAQAGDLDASYQFKLAYVRSLPSSKVESAALDVIATALRQQNVFDFDPIYRLEAVTSVKDSDLYSLLHIFLNDGLSEYKAWLGSHHEILAKNDLDEAQLERKIRLLSLTTLAFQNVGRDLPYSAIAVVLQVEPSEVERWVIDDSGLPVIRVGLVVGKLSQTAQTLHVVRATPRAFEHEQWETLEKRLVAWKTGLASVLEVVMAAKKKSAPEVPTPAVVANGLETAAQPPQVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNI3</accession>
    <name>A0A2R6PNI3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNI3"/>
    <dbReference type="STRING" id="98765.A0A2R6PNI3"/>
    <dbReference type="OrthoDB" id="2743463at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="45"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="13667" checksum="473A84DE5CBCAAC6" modified="2018-06-20" version="1">MEEACEHIERIVNSELGKRPRYPLEWGGDRATASADNEINQLDEQLIWRANVAASNRYEGSSESVGLHSDQLTAIGPYPTIASLSLGTTRIFRLREVIPTDEKDERSARTYNIPLAHNTVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVD0</accession>
    <name>A0A2R6PVD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVD0"/>
    <dbReference type="OrthoDB" id="3892913at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="12339" checksum="19A9CE2981C6C31A" modified="2018-06-20" version="1">MPLKYGSWAAQRSQMPWGKSKVETLRAICKELGIPYAKLRREEILELLLDVEKTGCKCAVQSIIQASKKFRVYVIQWTLCSKPEGIRERRTKAMKRSSNKAQAPRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEL3</accession>
    <name>A0A2R6QEL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pyruvate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v3646</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEL3"/>
    <dbReference type="STRING" id="98765.A0A2R6QEL3"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="55"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="228"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="432"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSS06588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="64943" checksum="C22AD0F7027795BB" modified="2018-06-20" version="1">MPTDKTQIAQVVASLEAELNRLKHEITTMGVADQVPAATETITVADYILERLKQLNVTDYVEAHPTIQWASNCNELNASYAADGYARVKEGSIGVLLTTFGVGELSAANGIAGSFSEHVPVLHLVGVPSTIQQKTKPMLHHTLGDGRFDAYHKAFQEFVISHGSLTDKVTAAAEIDRVLTECVVKARPAYLMLPTDLVHVQIPKTRLLTPLNTEPPANNADIEGFVLDEIMNLIEKADRDVVILVDACTIRHGVRKEVNELVHKTKFPVYAAPMGKTAVSETYERYGGIYVGTISSPEVKEKVENANLILAIGGVKSDFNTGNFTYHIDTHRVIELHSDNTVVQFASFPGIGMKHLLPKLTARLETLKGDAQQIEVPRFTHPVPQEDNETISHSWLWPRVGQFFKPGDVVVAETGTSSFGVLDVPFPDGAIFISQILWGSIGYSVGSTLGAAIAARDIGLNRTILFVGDGSIQLTVQELSVMMHVGVKPIIFLLNNSGYTIERYLHGKHAKYNDITNWKWTSLLTAFGGTEGETCQSYTVKTKSELSKLLDDETFARADKIQLVEMLMPMHDAPRALRVQAELSGLTNKYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QES3</accession>
    <name>A0A2R6QES3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="19">CPR</shortName>
            <shortName evidence="19">P450R</shortName>
            <ecNumber evidence="19">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v3548</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="19">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="19">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Endoplasmic reticulum membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Mitochondrion outer membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="19"/>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QES3"/>
    <dbReference type="STRING" id="98765.A0A2R6QES3"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 19" id="KW-0274">FAD</keyword>
    <keyword evidence="3 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 19" id="KW-0288">FMN</keyword>
    <keyword evidence="2 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 19" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 19" id="KW-0521">NADP</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="65"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="268"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="455"/>
            <end position="458"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="473"/>
            <end position="475"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="494"/>
            <end position="497"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="648"/>
            <end position="649"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="659"/>
            <end position="663"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSS06829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="736" mass="81513" checksum="629627F42B143CA2" modified="2018-06-20" version="1">MAASSSSDIIVLALGVILAAVYLFRDQLFSAGKPKAVPISSSKAAAGNGNPRDFIAKMKESKKRIVIFYGSQTGTAEEYAIRLAKEAKSKFGLASLVCDPEEYDFENLDQIPEDCCVFFVMATYGEGEPTDNAVQLCQNLSDESFEFSNGEHKLPGLKYVAFGLGNKTYEHYNLISRNVDRDLAKMGAIRIGERGEGDDDKSMEEDYLEWKDGMWEAFAQAMNVEEGQGGDSPDFAVTEVAEHPPEKVYLGELSARALTRTKGIHDAKNPYPAPITVARELFQMGADRNCVHIELSTEGSGITYQHGDHVGVWPSNAEVEVDRLLCALGLYDKRDTVINIESLDPALAKVPFPVPTTYGTVLRHYIDISALAGRQILGVLSKFAPNPEAETIMKDLNTNKDHYQATVAHGCMKLGEVLQYAAANDLFAKPTPETTTAWKIPFDIIVSSIPRLQPRYYSISSSPKLHPNSIHVTAVVLKYESEPVDRVQTRWVYGVGSNFLLNLKYATTHESAPLISDDAKLEPAFVEVPSYPTYAIEGPRGAYKQENILKAPIHVRRSTFRLPTNPKSPVIMIGPGTGVAPFRGFVQERVAMARRTIEKNGPEGLADWGPIRLYFGCRRSDQDFLYKDEWDSYAKELQGKFIMRNAFSREPPYKPDGGKVYVQDLIWEDQEHIADAIINGKGYIYICGDAKGMSKSVEEALCKILGEAKGGSAEVEGVAELKLLKERNRLLLDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEU1</accession>
    <name>A0A2R6QEU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase alpha subunit B N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEU1"/>
    <dbReference type="STRING" id="98765.A0A2R6QEU1"/>
    <dbReference type="OrthoDB" id="2994230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="25759" checksum="397E6EB5ACBF4A5E" modified="2018-06-20" version="1">MSATDSLRQQISTHFGDEVGGNLAEECISLCQMYNLTADELFFKWEALASTLGSRVLNAETIDILRSNIHRKTTKPETKSNLNMNIVTSKRLKGPPKLGGSIYSTPKKPLAGPINGANTGDSSRAGVAGPSKVQFVGYNMDGDSRSTRRFINIKELTVCVPTIALDDRIDDIAELVQKHYDIVELGDPSKATEVRAIIFNTATALSHFADLGGNHSSRSNSSRWRFLVYGIRQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEX4</accession>
    <name>A0A2R6QEX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEX4"/>
    <dbReference type="STRING" id="98765.A0A2R6QEX4"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS06632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="67137" checksum="F74E000338DFA9A5" modified="2018-06-20" version="1">MTEVIRIPNSLYPSIAVPETYDDFRGKGVPLIIDNGSTNLRFGFATSSSPRSVANVVAKYKDRKQNRPLLLFGDGVDAESGARAQARTPWEGDVLLNFDALWILQNLCEFSVDYPALLRKLKDPLNLRAHEKVIQFPFTVPIVEEKTEEELARIAERKREQGRKLQEIAAKARVEKLEQKETDLQYLTSLRERREEENKKDWLATLKEEGYDNDAALESAIKKLETDLKKARKKDVDGEDGEDEVPSFPLIDTPDAELDEEGLKEKKKQKLMKAGYEARERARKEKEREREEREAEERREVEERERDLEGWASKLKQEHESIMSKIKERGRRRAALNDRKSAASQARMKSIANLAADERVPKKRRKVGGDDMFGADDADWAIYRKINNAAESSDEEEDLANLQTLEQKLLMHDPTFTTEHTHAALSSQRSALMSAFRPQYEEGDVEGKTRIHLNVERWRVCEAWFSPTMAGVDSAGLGEVLQNVLSRFSDAEKGRLVKNVFVSGGPSQLPGLIDRLNLSLRPILPPDMPLEVVQAADPCNDSWRGMADFAQTAEFPRVGVTKEEYEEWGGERIKRWWGGNWNSSVPISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIL2</accession>
    <name>A0A2R6QIL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIL2"/>
    <dbReference type="STRING" id="98765.A0A2R6QIL2"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS08840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="44805" checksum="E05BDC2C913C35B9" modified="2018-06-20" version="1">MYADGTCPSTTAADGTVTRGACPEAYGMLLGTSIICAFLEIFMSFVPPRVLQKIFPPLVTGTVILMIGASLIGSSGIPDWGGGSNDCAGRPTSGIFELCPTIFAPRPLPWGSPEFIGLGFLSFISIIITELFGSPFLKNISIIVGLVVGCIVSGAAGYIDGSSITTAPAITFLWVHTFKIRVYPPAILPMLAVYSQFPLKHLKSFMMAKLIHPMLFVVSLAMEAIGDITASAEVSRVPVDGEEFDTRIQGGVLNNGVIAITRCANRTAGRFCCGFLILFGILGKISGVFLAIPNPVLGGVTTFLFASVATSGVRVLSYIRFTRRDRFILAAALSFGIGDLLVPTIFTHLFDSVKNPNKGLQGLFNSITIILSTPFLVAGIVAVVLNLILPQEDSEDDDDDVIGIPEVIDVEAHEAEKVKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUG2</accession>
    <name>A0A2R6QUG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000312">
        <property type="protein sequence ID" value="PSS15390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUG2"/>
    <dbReference type="OrthoDB" id="3252362at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS15390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="774" mass="87346" checksum="8C53EA123EF07B78" modified="2018-06-20" version="1">MANGVLSHITQAKNPACLPHADDTDGDDHMYTADDFPALAPEPENIFQGDFFGTDYQGDELDWLEEGGRGRGQAGSEPTASDPEDSDSDASNYNSDDATPTAMGWEAPRQTTTAENDKVSNSEPAEREILEYNPVNRQRIETALHQGMHIQAFPDTTGAGSPVLEGNIPDSHPAGYGLYEAQIRKLCNNSHSRDYAPFLSKLEWEVARWAKLRGAGSTALADLLGINGIQQKLGLSFKNARELNKIIDSLPAERPKFKCEQIVVAGEAFDVYFRDVIECIRALYGESRFARHLVFLPERHYADADRTMRLYHDMHTGKWWWAVQKAVEANTPGATIIPIIISSDKTQVTLFSNKTAYPIYLTISNLPKDIRSKPSQRGQILLGYLPTSKLEHITNKAARRRTLANVFHACLGRILAPLCKPGVDGLPMTSGDGVTRRGHPIFAAFVGDYPEQILVTGVKSGQCPVYDVPHDELGDHCSLSHAFRDIDKVLDVLDTADESPTEFMRACADIGIKPIYEPFWRHLPYADIYLSITPNVLHQLFQGLVKHLVSWIKSAYDPVEIDARCRRLPLNHNVRLFFKGITSLSRLTGREHSDICRILLGLIINMRLPDNLHPGMLVCAVRAMLDFVYLAQYPIHSDETLASLHNALCRFHDNKDVFVTLGIRADFHFPKAHFPQHYRFLIENLGTTDNFNTEYTERLHIDFAKDAYRASNRKDEFPQMTLWLERKEKVLRHNQYIQWCEAGRPPLQIINPLHKLHTSHVKMTRYPSAKSCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0W1</accession>
    <name>A0A2R6R0W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000287">
        <property type="protein sequence ID" value="PSS18883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0W1"/>
    <dbReference type="OrthoDB" id="10016792at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS18883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="718" mass="78719" checksum="B553730CAB82066F" modified="2018-06-20" version="1">MLPDDQSFRMIQLGQRTVILSVSEAGVQIGQGTDIGPQVTDSVNGYYIFAQKVTVVDSFSVTLSKDSVGSKSSDPIAAICTSDLSLESSGLVTLDVSGAAGIDNDTGAQRGPTINGKPAGSLCVYIENTTSEAVHSLVLKARGGDGGDTREKQGTAGDGGKGGQVQYIAYSYLTDVYLKLDFFARNMSWNRDLPGNTPLTPDHPIVVYLQQAVDLADALSQSNSISEDIRSTVDMSQPIANICAKAQTLQPPTIDNARDAVWEVRQAVRAQLDSDDLAITIYVEGGQGGSPEPSLSGGERGQPGQPGQRGNILSTEFLYRIDADLLRTQTMVFVHPEHCQMLYERAMTYWYFGRTSTAMDLLSRLLFRTSFLPLKSTDALYQAYEKQEKVLGCTNSVAGLVDVRTRAMQQYSILLTGQVDFYGHSVFWVPRVAYSDYNKYIDGAMDVYIHLEQSYINYCAALDQQQQTNDAIQQSAAKIDGTLATMQTERVTLVSSLQDLESKIKAADPVVEQKHRDFAAAYQEFEDIFNKPPPHGITPRQLFNAAITMTSLESTSKVVTTAEAIDQLWSDFNGDPDHIQTDSGVPVNKEYLMGQIKRSIVTGLDDFTSELTTAELNGEFQVDGRLPKFVMEEGQLNEILSQYSNAAFAEAGQELVDAYDDFIKALSSRNDDIVAYNAVIRLIVSQSQEMAKLKAMKELAGKHTMIDAECYLRMPGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R757</accession>
    <name>A0A2R6R757_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000277">
        <property type="protein sequence ID" value="PSS22605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R757"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="7306" checksum="1642D572C2089AE7" modified="2018-06-20" version="1">MSFHAERRVLESEKRGMLLVTWDELSRRQMSRQWSSSSNTSVASRVLQDSQQVTEMSNLWCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIC5</accession>
    <name>A0A2R6RIC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIC5"/>
    <dbReference type="OrthoDB" id="2798876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015313847" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="9874" checksum="5A2E88327547E078" modified="2018-06-20" version="1">MRPASFIVSLAAAAGVYAQCSSLGTDASDSASEFTLSAFNPASGITSPLHLVNVATVPENSFHVLSFSIQPSEGVDNDATDSIRYHQLAWLNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ64</accession>
    <name>A0A2R6RQ64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2044</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ64"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ64"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="663"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS32171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="840" mass="90601" checksum="C38A0D35CB16A100" modified="2018-06-20" version="1">MLTIQCADTEALDAFSKTSAPCVRLRRILSIQYDGPPVTTLDLTEYRHPFQLLQFQDVTEDIQDACWWKRQDDDSSADKRVLEGEIHLKHSADPSALLGRYGVSYHINDYLKRNLDSTRGNSLTTRRAARRPDGELVDYDNISNNMSSRAGGLYGGIQFSSSKAFVSSSIPQDVLPPPSASPAIPVAKEQPSTTVQPAPSTSSTNNVDSGASVKASAGWSASLAFAPIRRNQTQKPKPAVSRLPVGAAVTTATATGSSSATISSTAIVFAPPSLVELSKVQPSSQAQNAAQGQGWGKKVKPPSMILDEDVNGYKAQRGGKKAGGGKKNKKNKYAPALPSWDPSEMYDPMRPNDYNEYKIWKRKDREERRERELEAKLRAEDKKRNRRSNSYSDNSYGSGSEDERPRKTGRYDEYESRREPVNYEDEDDYDRPRGIGISSATAAAVDVRLTGDEAYQRRLAMSAGFQPATSPATLIAGSNPSAPSFAPSNTFAIALSTPMNAPPEALPPMLSAGLYSPMTAPESSNTLSAAVDDDEIPGFGAPPPPFAAPTVETGEEAYLRRLAMSQPRQAAPAFVPQPRPISPEPPTLAFNPFAPPTSVPPPSAAGLPVSGGALSEEKVRSSREAAAAIAAKLKALAPPPGSTEASGSTTPSAEPAPSKKPEPHNFAARLMAKWGHKEGQGLGVDGSGIVHALTVEQVRSGKSKGEPKEKGKGVSKMGKIVNKNEDAKVKEDLERFGEPSRVVVLTNIVSTEDVGDVELAQDIREECSKNGTVEDCQIHLVTPAPPTEDEAVRVFLQFSGPVGAWKTVRELDGRYFGGRSVRARYFPEKYYNQYAWNVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ65</accession>
    <name>A0A2R6RQ65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General vesicular transport factor p115</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000192">
        <property type="protein sequence ID" value="PSS32164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ65"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ65"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="510"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="7">
        <location>
            <begin position="721"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="723"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS32164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="90617" checksum="61A561E4BEE01BBA" modified="2018-06-20" version="1">MEFLSQTYIALRGPTGAPQSASDAIARLSDRLSPATLLADRRAAVLSLKGLTRDCKAEVGDRTLPGLLEVLQNDAEVDADTGKAVLETLNLLCEVSEDGPAHAKELSFKYTDYVLADEKTTHKLFALLGDHSFYLRLTVLQFLIVLLQNRRQVVQAYFLKAPVGPTTVISALEEKREIIRTEALTMVQYLLSQSPDIQKILAFEGGFEKLFNIITQEGGLEGGVMVHDALACVDALLRYNASNQSYFRETALPPVLPSLLLFPPSLPPHEPAPQGFALQFWDPHQKRANAALVVSIMGILVGSKGGSPQETFAFCRCLVELGLASNAPSSLKTLSLQLLPVNLTFPLPSMTITPYMPVPDTNGEEWDRLEPASALDALVELILHGEYNGIHSGKRTKDGMELRGAALEVFQNFVQKDQIGEAIVQAMAPVEGSSEPPPMTPLLQALIIPPASPLEIAAVTSTHLATLLFSDLLRFSSRAKTVARKIYPQPPSSSQDTGSFFVPADGAAPAIHVSDEVPDDDEPQSLLQILSEHLSLALLSRRRADTSEREAREWDRLIVGYLCLLIQWLWEDPAAVRDFLEAGALGMLVEPINQIPESDPVIPGLCAFLLGLSYEFNREPGEISRSTIYPILTRLGIDMLVGRITHLRDDDRFKAIGPDTLVLPYPSQGITNSDGEKEAEIWFDWAFVDFWKSNYYTVQKGIAIDPKAPPPSAGQNAETATLVASLREVIQRQAQDIESLQSKLKELSTQSEEIEALRTQIASVQEELAEAQEKRQEVEKEQEDLLVLLDELGSKRRRDKERLKSSGMEVSEDEEEGDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3R5</accession>
    <name>A0A2R6S3R5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="MLYV02000093">
        <property type="protein sequence ID" value="PSS36921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3R5"/>
    <dbReference type="STRING" id="98765.A0A2R6S3R5"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="97"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS36921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="206" mass="22885" checksum="C357AF94C88B9C3E" modified="2018-06-20" version="1">MSGQHTLPDLPYAYDALEPFISRQIMELHHKKHHQTYVNALNAAEQAYAKASTPKERIALQSALKFNGGGHINHSLFWKNLAPAKSENKGNGGSLHEGPLKKAIVEAFGTFDNLKKEFNTTTAGIQGSGWGWLGVNPQSKRLEIATTSNQDPLLTLTPVIGVDVWEHAFYLQYLNVKVDYLNAIWNVINFEEAEKRYLDAVGGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3X9</accession>
    <name>A0A2R6S3X9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3X9"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="196"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS36972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="305" mass="32693" checksum="CEDC827126C23CE5" modified="2018-06-20" version="1">MFTPPASPAPPRVFRQPSPSPSVSDDEGSSQYLLVLPPRSSSLGPSSSSLTLPSSLLPKPHKAQSQHVASIVAKQRTARRTRWAVLLVPAVLILITLSTRYLSHPAVLDILSTNYDAPSWEMWSTTLTDFKPHKRHASPDPEPQQASSLIAFPTPTTTLTSSASSASVSSSSTASTNSGTQTIPTIPASPPTLPTPFPQPLDDTLSQNFTTISCQDFFQNMTQSTAFRSCRAFSLLSQSSDAFIQQAQDNITSLNAIIWGTCHTDVDADTCTSNMAWFTDALADQCADDLKAGNPIVQQTQTGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S453</accession>
    <name>A0A2R6S453_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S453"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7529" checksum="CCF1AD91DC1082BB" modified="2018-06-20" version="1">METGQQCITLVAREIPTDEPTSAVSRPKLMGKKSPRVRPLGLVGDGAQECGSSPTECSFRNVRLDNVSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4C4</accession>
    <name>A0A2R6S4C4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4C4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4C4"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="234" mass="25096" checksum="8D11E3C929EBC7B4" modified="2018-06-20" version="1">MPLHPEVLWAQRSSENDESKNILYVTINLPDIKPETVTYELTPTSISFAAKAGHAENGLEERDYAFKLDFFEEVDPEKSRKNLTSRAFALILQKKEKKAEFWTRLTKEKIKTTFVKTDFSKWVDEDEQEGEPIKDEDFDMGGMGGMGGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMGGMDLEAMMKSMGAGSGGGDSFDDGADVEDEDGDDDGPPPLEEAEPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4K7</accession>
    <name>A0A2R6S4K7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Octanoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v1022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4K7"/>
    <dbReference type="STRING" id="98765.A0A2R6S4K7"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="9">
        <location>
            <begin position="38"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS37149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="262" mass="29446" checksum="845393ACB674F7CC" modified="2018-06-20" version="1">MSVPPVFFHCFRVPLPYVRTLALQEQLHALQLTQRRSSAHKDILLLLQHRPVYTAGRRQLSDSPEVQADEARLKRIGADFITTKRGGQYTYHGPGQIVGYPLLDLGRTSPPMGIREYICRIQKTLTSHLSEAHNIPTIPSDNTGVFLDEHTKIASIGVQVRHRLTSHGFAINVTSEPVKWFEEVVACGLTDVKAGNIAEATRSMSVIEVEGEMDQLVQRFGQVFERDMVKLDLESDVECGEAIRAVEEEARKAGEWLHTPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4K9</accession>
    <name>A0A2R6S4K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000070">
        <property type="protein sequence ID" value="PSS37230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4K9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="6559" checksum="930D5B1FD7638390" modified="2018-06-20" version="1">MHLSSTLNVKGERGRPGRKNLSLPFETEGVAAGAACRVGRPQAPSPSIFLIDVVVGEPSSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4R8</accession>
    <name>A0A2R6S4R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000067">
        <property type="protein sequence ID" value="PSS37290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4R8"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="259"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="459" mass="49770" checksum="B0A65976639C2EB0" modified="2018-06-20" version="1">MSPSPLTALANLVSSSIQTLEAAYAKEGLVFPSLDEPFAPSPLDNDQVLAQTTRVLVAAAAQIIATVRPPMDTIQDYAPAMYMSATLGTAVDINLADILKNSGSQGMHIRDIASQSGTDPNKTGRILRYLSSRHIFREVTPDVFTNNRVSSILTRAKSLAEIKKDPVGSFEGAGPAAFVGHVADEGLKSAAYISEYVREQPAGIDAPFHLALNEKGSIWDWYDKPGNDLRGRRFNSAMSGGGDMFPPAIFTKDVYWKHLTENDVVVDVGGNVGTVTMLLVKAFPKPRYIIQDIAKVIEDGKNYWNDKFPEALADGRVKLQAANFFEPQAVKGAAVYFMRLVLHDWNNVACKKILTNLRAAALPSTKLVLFEAIMPHACPGTGPYAYATRTGKEDPPYPLLANLGVGGGFATMIDMQMLALMDGQTPTIEEWLDLFPTAGWKLDELHVDGPLAGFILSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S549</accession>
    <name>A0A2R6S549_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S549"/>
    <dbReference type="STRING" id="98765.A0A2R6S549"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000022">
        <property type="entry name" value="protein EXPORTIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1061"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1061"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1093" mass="124267" checksum="7C4137E244F89122" modified="2018-06-20" version="1">MEVSHSLATAFVSVGVLSDTQGILDFSKEFDIQLMDKVVMAFYAGAGQEQHMAQQVLTQFQEHPDAWTRVPEILEHSSFPQTKYIGLQILEKLILTRWKSLPEGQRQGIRNFIVGITVKVASDESMLRREKTYINKLNLALVQILKQEWPHNWPTFITELVESSKTNLSLCENNMVILRLLSEEVFDYSAEQLTQAKVKNLKNQMCGEFSEIFKLCSEILEEAQKTSLIKATLETLLRFLNWIPLGYIFETTIIDLLLNRFLEAPDFRNVTLKCLAEIAALNVGPEYDPKFVILFAMVMTSVNRMIPPNTNIAQAYANAGDSGQELVLNLALFLSNFLSNHLRAVETEPNRDVLLNAHLYMVKVSQVDEREIFKICLEYWLKLVAELYEEIQSLPIGDSGLLMGLSLGGGSQNMLNGMNLRKNIYSDVLSNLRLVVIEKMVKPEEVLIVENEEGEIVREFMKESDTIVLYKSMRELLVYLTHLDVNDTETILTEKLAKQVDGSEWSWQNLNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLCEIKRGKDNKAVVASDIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIAQKCRRHFVMQQSGEQEPFVDEILRLLHRITVDLSPQQVHTFYEAVGYMISAQPNKPQQEKLISKLMELPNNAWDSLMAQAAQSMDVLSSMDNIKILANVLKTNVAACTSIGTFYLPQIGRVFLDMLGLYKAVSGIISETVTREGLIATKTPKVRQLRTIKKEILKLMETFIRKAEDLETVNSNFMPPLLDAILGDYSRNVPAARDAEVLNVMATIIGRLGPLLTPQVPAILDAVFEPTLNMINQDFAEFPEHRVGFFKLLRSINLHCFPALLTIPPPQFKLFMDSIIWAIKHTMRDIAETGLNLCMEVVNNFAGAEPQVSNAFFQQYFLSIMQDIFYVLTDTDHKSGFKLQSMLLARMFQLVETNQITVPLFDPSTVPDANVTNSVFLKEYTANLLKAAFPHVQNAQVQAFALSLGEHHSDINRFKLALRDFLIQLKEFSGDNAELYLEEKEAEAQRKAEEEREAAMRIPGMLKPSQIEDKDEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S568</accession>
    <name>A0A2R6S568_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S568"/>
    <dbReference type="STRING" id="98765.A0A2R6S568"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="73"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="164" mass="18219" checksum="48793067B0FCB93A" modified="2018-06-20" version="1">MAKEGTAHPRQMVCLYLVVYMTIATYDVLTYCFDSREHISIYTLHGEPLVFQHFDGPFYPTLKLLHKYPFVLPKVGIDRGAIRFLLAGAHMMCPGMTSKGGYLPAEDVALPAETPVAIFAEGKEHAVGMGITKMGTEEMKKLNKGVGVETVHYLGDDLWAIQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S589</accession>
    <name>A0A2R6S589_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S589"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015304225" evidence="3">
        <location>
            <begin position="24"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="281" mass="29026" checksum="5302BDDA3C1961F7" modified="2018-06-20" version="1">MRAVSALLSLLSLPALLAEVATAAHGNVANRAENHRRLAEVVESSNHTLTKRDQFTNARYTYYNVEDGLQVACGGFYVNTGWTVALTTLQWDGGSHCGEKITISWQGKTTTATIVDECMGCPWGGLDFTPSLFTWFAGSTEAGVLYGSWDFGAAAPPPPPPSSPPPPPPPTSTYHPPPPPPPTSTHHSSSPPPPPPPSSSSHSSSHSSSHSASSSAFSSSSSSWVVQSSSSSVSALSSSQSASSASSSVLPSATPSSPSTLNQMFLALVQLSELSASSGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S649</accession>
    <name>A0A2R6S649_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transaldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S649"/>
    <dbReference type="STRING" id="98765.A0A2R6S649"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31586" checksum="9B2AD2C6EF89E9B9" modified="2018-06-20" version="1">MPSLLDTLRTQTTLDVDSMDPEVAAKYEHTFTDMTSNQAIVYSEAIRPERANALKAACEQAKATGLDIDHQLSDALDLLTVLLAKDVFPHISGRVHAQTSPAHAYNTEHTIAHAKRLVTLFEAHGIPKSRVSIKIPATPESIVACHYLEKIGIRTLATCLFGLPQALAASQAGCLYVAPYFNGKARLPSALTLNDSHRVQNLPFISSLASGKPIQILQMSILCLTAKEVCASPRMQDMQTHRASSQVIALVSLRPDHITLSGAVLEQLASESVESDQKTEIIDTGNADDIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6T9</accession>
    <name>A0A2R6S6T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000011">
        <property type="protein sequence ID" value="PSS38010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6T9"/>
    <dbReference type="STRING" id="98765.A0A2R6S6T9"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="779"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="896"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS38010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="101893" checksum="BFAF6413951159FE" modified="2018-06-20" version="1">MTKGGRGGNRGGYRGRGRGRGGGSRGGKGGGGGRFDMMDDDDFTIHDGAYNSSRGGPNSGLNSPRSRGRGRGSGFGSPRGVPPSPRGDYNSIGVRGRGERGSDPQYTDRGRGRGRGRGGSADADLATIRGRGGKNWPAKMRAGAPLSKLLYADRPLLRPIEFVRSVHMATLFQQEEELLQPISEEVAHDERSHVPTADQVFRVFSGKAEEDANEESDTEGLEVIDFSEVGRLQAEVDAAAAKQQTRLKTEVNVVQERFTGFYIDTEPTPVLDVPLIPSSAIGGLVLGEQQDDEEIIVYVAPHPRAGPVTPPPEAENLYIPPSVSILTGLPVSTLEANSPSHPTPLISSDVNEVNVTSSPSYPVQRSLDVEMTVQGDVSLKEVSATPAESSAEPVTSVAGPSSTSAGPPAQPLSTPIPFESLSFSFQNTIQKKIARRIHPSQTPRSLIKKGKPRKRASRRFGSYGANMAEAHLQEEARDPRQHERRVGDSDLDWGDESEAGDGVDELSSGIGAMDIDPDIDLAAMASFAKTMSAEGSRQTTIDDIADEERIRREDEEGSSSQETDGDDGDSENSEDEEVEMVVSQAEKALIAEGADESEEGSEDESDEEDTPRRGFQTRLRRIREITKGKRKADPHQEPASDVDDDDPELFMDQSWADEDEEFIAHIEAVLDANGELLSKDHIQRDKVFRSIHNGISEIDDYEQVISGPAKRKKDDIAPELQDQWEKDRAKKAENKRKRALQRLEVSTDPLAMKKGGKKGMKDMLTAARLDPSIEVPNRVVDLVTLEQQIPRFLDNIGGKTSMVLPPANKETRKKIHELATAFNLRSQSKGQGKTRYTTLIKTTRSGVGINEGKVRKIMKSVSPHWEGPTKGGGKAMSLAKHKEGEEVGKAAPKIGETNIGFRMLASMGWVEGDLIGLSGGLEAPLTAIMKKTKLGLGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE22</accession>
    <name>A0A2R6NE22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001342">
        <property type="protein sequence ID" value="PSR70627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE22"/>
    <dbReference type="STRING" id="98765.A0A2R6NE22"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="80"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="586" mass="65496" checksum="15DA601D9DF0E0E6" modified="2018-06-20" version="1">MVSDLTFPSGSGDDQLVESPTDSPPVIPSELGQDSTTRSKQMPIVSGDNSNNTAYSSGSGEGEEHSGVCDGIIPSLHHARNLVLCFDGTGDQFDADNSNVVQFFSMLQKDNRQEQMVYYQAGIGTYTPPQIATPFVAKVSKTLDEMVAWNLSAHVMDGYEFLMQNYEAGDKICIFGFSRGAYTARALAGMVHKIGLLPACNHQQVPFAYKMFTRTDPKGWAQSTAFKKAFSMDVHIEFIGVWDTVSSVGLIPRTLPFTTSNTVVKTFRHAISMDEHRAKFQANYWNRPTKEEEKLGTARGDMPKSDGGMASKGVKREQGGHGDGDKDQHRDRDAKTAKKHRLHQWELERRFSMLEHEEMETDVLEVWFSGCHCDVGGGSVPNHTRHNLARIPLRWMIRQCFLADTGIRFHAELLRTVGLDPASLYPVVLTRPPPVYLSPSVPHPLTETPPLNLGKLKLIGSNAQPTLPTSGTWGSIGYACHDSDGPKLSEEEEDLADALSPIYDQLELAKYWWALEVIPMRHRYQNEDATWSTDISMNLGRGRRVPRDGKGNFFVHRSVKLRMESKDLKGPYVPKAQFKFEPTWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE41</accession>
    <name>A0A2R6NE41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001338">
        <property type="protein sequence ID" value="PSR70647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE41"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="13464" checksum="51837AAB33B137F8" modified="2018-06-20" version="1" fragment="single">VERAFTASAGGYVNQIHSWFSDRNWGDVSLKYLAATQTLSNATWSIIVRRAKATMDKAGPDQFKILKDLPEQPVNDYAVDDIIDEEWLAANQLEEGDGAKNEGSTNEGGEVGVEDMKVEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF47</accession>
    <name>A0A2R6NF47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF47"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="174" mass="19787" checksum="4CC7FC9CA37FE8A4" modified="2018-06-20" version="1">MEDDWSGLKVGTLAHDWHPEEASHRSDEPVSNTTLKDPTGNSWGNFIKPGSQANKQRNRAERCRIATPHPSDQPQEGAFPLTIESEKPQLPSCQLRATRCPREQDNNSTHLIDGLDPNGLPSTSFLRAVHRAVFYETILLPYRFSSKSKMRWVECTTIWISARQWHVYGFGNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFL1</accession>
    <name>A0A2R6NFL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extradiol ring-cleavage dioxygenase class III enzyme subunit B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFL1"/>
    <dbReference type="STRING" id="98765.A0A2R6NFL1"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="67"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="272" mass="29930" checksum="995CE0A8234194BE" modified="2018-06-20" version="1">MSPQADTNASLPKTQAEWRKALDALPSTPDNIPAFFFGHGSPLLAFEESDLGGRFNPSVIKHAGPKGPLASFLKDFGKTLLDKYKPKAIVVFSAHWETDTERVVTDYGGENPLLYDYYGFQPALYELKFKSRGDSGISQRVVELFKEAGHLSRTTSKTESRGEDGRGFSGPGFDHGVFVPFRLMFGTEFMDVPIVEASIDATLDPAKNWAVGQAVRKLREEGVLVLSGGLTIHNLRAFSCFAEESAEPGYKEFDKAILDAVALSDVSWFIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGA6</accession>
    <name>A0A2R6NGA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGA6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="78" mass="9037" checksum="DF23730E1F5A04D8" modified="2018-06-20" version="1">MGRQVRLVTSDNLVRKHTGKTMTPSEEALHPIRIDGFFCEHPNDRLRCHTTVALSRKSTHEKEYVPPEIQHLDIMMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGM1</accession>
    <name>A0A2R6NGM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGM1"/>
    <dbReference type="STRING" id="98765.A0A2R6NGM1"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="7">
        <location>
            <begin position="209"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="419"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="498" mass="54466" checksum="2772AACE4E4E74BA" modified="2018-06-20" version="1">MSNLKNSPFGKRLRASHHQENDEDNHRRTRPRTNLIFGVATASTPSLDSRPTTSESGGSDATAVAKDYGDRFVPTRETGDMRTSYHLMDEVTPSTPSKTRIIPTESDALKEQANNIFASILQTEVTPMSPHRPASPTRQSSVPILPTTPTRRRLFAYNSPSNPATPTRRLDTPTDEAYSMSPVRQESRQLLESPRRQLRNVCKTPYRVLDAPELADDFYLNLVDWSSTNVLGVGLGSCVYLWTAHTAAVSKLCDLSETSDTVSSLSWVQKGTTLAVGTLSGKLHIYDANTLQRQRTYQQAHSNRIGALSWNAHVLTSGSRDRMIHHRDVREATMRPFKRSMGHKQEVCGLRWNGETGPQSAVLASGGNDNKVCIWDLRGSKRPGLRSATASGSNSGANSSAAGIAVGGEEGNDAPIWKFHEHTAAVKALAWDPHVSGVLATGGGTADKHIRFWNVANGSMLSELDTGSQGTRHCDFGMPFPKKTITHPNGRVDWTTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHD4</accession>
    <name>A0A2R6NHD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001245">
        <property type="protein sequence ID" value="PSR71733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHD4"/>
    <dbReference type="STRING" id="98765.A0A2R6NHD4"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="125"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR71733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="480" mass="52161" checksum="3CB0C91BBD32DFD6" modified="2018-06-20" version="1">MSTPAPAAPIRKKRNFKALQLDVSQPSSPVAEPAPTRLAPAPGGATGGKKRPPPMKLAPKVATNATAATVDQDNALLTVGGPNSAPPTGSMSTHRSTYHSTLSSTLANLDNNSENKFHDLHNEDLKDLHELGQGNGGSVKKIVLIDAKPSVRKQILRELQIMHDCNSQYIISFYGAFISDPNICICMEFMDKGSLDGIYKKIGPIDIDVVGKVALAVLEGLTYLYDVHRIIHRDIKPSNILFNSKGQIKICDFGVSGELINSIADTFVGTSTYMSPERIQGAQYTVKSDVWSLGVSLIELALGRFPFSDSSSDDSDLSDFESTLSPRRPGNITIKSAAEAKVEKEKRDKKKKRKSKGVSLQGGGMTMSILELLQHIVNEPAPRLTPEGRFPKEADDFVDSCLLKDPISRRTPKDLLVSAPLFTSPVQNMFSDMLHTLIRNTLGLITPGRIPWTSRPGHLHSNPDMKLPSTNGSPALFDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHD7</accession>
    <name>A0A2R6NHD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHD7"/>
    <dbReference type="STRING" id="98765.A0A2R6NHD7"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="18102" checksum="B8FC44B091C7AD4B" modified="2018-06-20" version="1">MSCENKEVIRPGTAGSDKSDSTKKTQVQFERDQAQDGGHEKVGQMQNITNGPQDGDESAIPEDRKEDAIENAEDDWVHDPRNPRNWSFWRKWEMVSIVSLYTFVTPLASSMMAPALPEIGEHLGITSETVIAMTLSIFLLTFAIGPLFLAPLSEIYGRTWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJP1</accession>
    <name>A0A2R6NJP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="2">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001152">
        <property type="protein sequence ID" value="PSR72597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJP1"/>
    <dbReference type="STRING" id="98765.A0A2R6NJP1"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="5">
        <location>
            <begin position="93"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="261" mass="27894" checksum="C00CE973FB9FDB8B" modified="2018-06-20" version="1">MLNLIGASNDLAEIKEFAGYALSIPGTTVHLYGKEECRKGRKMGHITIVASSDAELRDRLRPLLERLPGSNDAKEIDLYAPPSPSQGHSHAFPLVGVIMGSDSDLPVMLPAARILDRFKVPYELTIVSAHRTPDRLVEYARTAASRGMKVVIAGAGGAAHLPGMVAAMTALPVIGVPVKGSTLDGVDSLHSIVQMPRGVPVATVAINNGTNAGLLAVRMLAVAIPELIISMEGYLKSMQTEVLAKVETLEEVGWEKYELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKV2</accession>
    <name>A0A2R6NKV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKV2"/>
    <dbReference type="STRING" id="98765.A0A2R6NKV2"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="14383" checksum="95DB4A7B9C7A3133" modified="2018-06-20" version="1">MSRPAEAETPQEAAAMHDYRARIWSAFQEVYEDRWNQEDFRSRHDATVIDSLRAKKKMPTWEALEAQLKRGPPPFLRPGWVSPLQGRQVDLDWIDQDAFVWIRGNKTGWRDAKLLVIEFWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL09</accession>
    <name>A0A2R6NL09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR72991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL09"/>
    <dbReference type="STRING" id="98765.A0A2R6NL09"/>
    <dbReference type="OrthoDB" id="3153997at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="252" mass="28119" checksum="B8A7B422DA371B09" modified="2018-06-20" version="1">MPGPCNSRKRRQNQAKKEKRTKSARIFVPESSPEPTQDVPQSIPSSSSRCTSTPPQPTTPPPTYHSEPRRATNTAESLTAAENDLGLLKRPCIEDNGDGPHVRDVHEFLETRFAAPPSVEDPLCAQFALEEVLEMLCAVLPEETATLADRIITSGSSFCFFLAAHRYPTALRSLWGHMADELSDETWDELERPVGKANDLGLSMLLKMTRCHDLGLGQLFFPDQDLTAFPTTEKEEYERDRGRAMAKQNTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL49</accession>
    <name>A0A2R6NL49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL49"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7775" checksum="CB6ADF5965D2EF61" modified="2018-06-20" version="1">MSSTRREQPHLYHTAGLYPLDPGSLWTMTQTTKLKIIQKSLVTIMWSSKREEVESQRGGRLEDVRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLE3</accession>
    <name>A0A2R6NLE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLE3"/>
    <dbReference type="STRING" id="98765.A0A2R6NLE3"/>
    <dbReference type="OrthoDB" id="3149711at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42439" checksum="6ABB2A07E011023D" modified="2018-06-20" version="1">MNAFHQNLLRMISSGASLKFLLIYHKHYRSLNSTRSFNRILALAIRQNKSRIAQDLFNEMQDRGVYHNVESRKLRTRMLVQQGCWYEAWELESAQGEILLPIWLEFLDIPQRSTVRTMQIPREGMAPELLPAKLVPPSTHVARFRLLLRNFPKIDSGQLAAMPPRTVYVIVRWMLRMHYRQPALDITTLYFRQLPQTINSSLHNLCLRIIHLHMLPGWKRGLSAHYIARRTLNTFLGMHPSFRPNPTTLFLLLRTLRSSKYCGTLAHQVVEEFKTRWGSSVIDGMVQQRVASLAIKEGRLDIASSCLHALDQHRHVLDETSYSRRGTEDREWKLLNGRLERLRKRREGASHQQQQEIPRQGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLP5</accession>
    <name>A0A2R6NLP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001085">
        <property type="protein sequence ID" value="PSR73320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLP5"/>
    <dbReference type="STRING" id="98765.A0A2R6NLP5"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="265" mass="30861" checksum="B088515A242675F9" modified="2018-06-20" version="1">MHFITDRAVEIGTEIQQYHGKWPFWRLGGMQEPASVAFSLLNLWFHIRGAKEVQLKIPEGHPMKRYYLIFAAVSVNAWIWSSVFHTRDLPATEKLDYFSAALAILYALFYTVVRLFHLYSVPNLTSNRRLIHNTWATICSLAFLGHISYLTLLPRFDYTYNMAFNLVIGMTHNLLWLLYSFPSFLSPFHRFPARAKTYRPGYVGKAALFVLLTTAATALELLDFPPWRRIIDAHSLWHLSTVPIIVFWYKFLIQDALDDGWKGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMR2</accession>
    <name>A0A2R6NMR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMR2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMR2"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="173" mass="19740" checksum="CBA5DC5D7947399E" modified="2018-06-20" version="1">MAFAIGTELHPSPPAYRIGVDVMLLQVPRRTTFEGFVETVSDQLTTYEQSILLPHSPLDPQEALRRFYLIWTLKEAYTKALGLGLGFDFKRIEYDVPKDVVHVDGVRPIGWEFVRFEIKRCEEIYVGVAAQYVGEDKDSDEDECTVKKMPAGDWLKVYDAAKFMESATQALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNG4</accession>
    <name>A0A2R6NNG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001047">
        <property type="protein sequence ID" value="PSR73940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNG4"/>
    <dbReference type="STRING" id="98765.A0A2R6NNG4"/>
    <dbReference type="OrthoDB" id="2689725at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="11274" checksum="FC9C1F519C010CB5" modified="2018-06-20" version="1">MDHLSTLKYQLIETEVIMGIEKRWEPQDDKYLETLKYAQTRQYHRALDHLQKLVVQRLFELQKLNLAETVLQQTIHELKKEAHGIHKGHKQAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNT4</accession>
    <name>A0A2R6NNT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNT4"/>
    <dbReference type="STRING" id="98765.A0A2R6NNT4"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="216" mass="24298" checksum="EC9039008B56744A" modified="2018-06-20" version="1">MAHVVQSLDQPSNYKDSQARVDRQKQNELLAKSTTLYVWDRPQIVRKGSGTTTSIALIPLYRTPCGFCFVEYYTHAEALASLRYISGTKLDERIIRCDLDLGYREGRQFGRGKSGGQKERLQVRDEHRSDYDPGRGGWGAQAQRVEIERRREVEERYADAQEGPGAVAGGGDDWKEAEGAVESSLKRGRSPDDDGDNARMGARTRLDEAEPEAERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNT6</accession>
    <name>A0A2R6NNT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNT6"/>
    <dbReference type="STRING" id="98765.A0A2R6NNT6"/>
    <dbReference type="OrthoDB" id="3069722at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="676"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="978" mass="105063" checksum="F7F1AF6ED8AF5D6A" modified="2018-06-20" version="1">MDNNLPYSDESEGSDDQDYTPRHSTRDLPREQSPSLPSTRTPPSPPSDKNISTQADPRRSHRRDRNRHSTSREVAKLLLSEGKESTQTRKILRAALARLDSETARAQEAERRALGLAERFKIVNDTRLQAQQELRDVQETLRLYKVQYDNARREIVRGQEIIKDLETQRDNAEAAAARARTIARKLKEDQLAILAREEGRKAGYREGLRRGLEQARYEQARAELGDSESADEQEEGPISTAPRTEPLDGLPVLNFSSPSADPVGLQSPAPRHPIPPLRSQSVPPVEPSSRFREHGIGITPGLENAALPSSGGDGWPTATEDTSNYTRPIPAPLSPRRRESHIPPEGWIPSADSDQHILLPPPSAFNPLLRSPHSPSQPLPLPIPPPGTVQLPHPQNGAESNMRDYAYMKHRSAPSLAESIPSIQSTTISQFDLVGPPTISQPQRNNGRDRRSGLSTIQEASSSMEYSPGLDSSAIPEPIVFPSGPGEQAGDSKWSRPAREEPRQDPAWGRTVHEPSQGSGWEGTAHEPSQGSGWGRTVNEPSRGWGSTANEEFEGSRTPRSRDANQRLADELRYDDPASIQDWRRNGTDERRSTSSSESSKGRRRPANLNMPAPLGDRGPPEPRPLSAASGGNAYQSHNMRPTSSPANSTGYPRSSSDHDINIYIEPPSGPPSSGPPSVGRSPVTQPHLLSPSGVPAPLPPHVPTVPNSPSMGPYPSLGALPGVIPVLPPGFVPSGPPSPMLSNAPLNAPPTQSSPRIVPQSLYPGGKPPGVPRVQRSSSSSSSGGITSLPRSNHSRSRSTGQLMGTSLSADSSRTKTPGVHPPSAAPSGRSLYAPTTGPSAGQYPVVDPAATVNFSPRSTASGHYRSLSLNAGSTPGVSSRPLSTAPPPKLRRVPSDGSADSGVSGTSSRRKTYTHYQPNQYVDPAFLASNEDLTANVFSPNTAANTRANASANRSDVPAVGFHHSSSPPYTNLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ23</accession>
    <name>A0A2R6NQ23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ23"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ23"/>
    <dbReference type="OrthoDB" id="2268893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="10487" checksum="45C7B59C1F603D72" modified="2018-06-20" version="1">MPPPVLSLPSSQAAASSETKLDSREKMQENVESYTDSELNVPVSGHAKLRRTMKNRHIAMISIGGVIGTGLFLGSANSLAAGGPVGLLLGYSIVGTICYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQK6</accession>
    <name>A0A2R6NQK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQK6"/>
    <dbReference type="STRING" id="98765.A0A2R6NQK6"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6297" checksum="80E9D8D31720693C" modified="2018-06-20" version="1">MGSVRGGSSRARNILQHGLNWMTEPCFRDGLNDRGKAMLDRLVAMKESAGDVGYSLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQQ2</accession>
    <name>A0A2R6NQQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NQQ2"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="16149" checksum="7EB91DE52AA16AED" modified="2018-06-20" version="1">MVATENLRRFFEQHFHELNDSFFKKLLLHLGRIMTLKRFNIVSGTPSLHTSERKSDFASFSRLLNRLPPTERGRRPFMNDLQAELHPMEILHDVKKLLTVSHVRISISQTTAYFHTDTKSKILATTDLSIFREDCTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQQ5</accession>
    <name>A0A2R6NQQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sister chromatid separation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9466</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQQ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NQQ5"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HeH/LEM" evidence="8">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="7">
        <location>
            <begin position="405"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="76932" checksum="51284DE22DED5F81" modified="2018-06-20" version="1">MSRALTSAQVIEKGDYLKPDFDPATLTVAQLLGVFGFHNINYPSPYTKGKLVQIFSDEITNKTVKLSKERLHRQNSQASDDGITDGVTGKPINEGRKAPVTRGASRRASRAPSEVVDPAPVKPEPVKRRRSSAEPSLGGPSRRRAAKPMEPVVVEDSEPDEPVVRKVSRNKKNATEAGARARRVSQTVAEEVDSGWEDNNVFQSGAESSPARPSPVRPRTRRPTAIPRASKAMSVPPQFAPPSPTKEEPTKIPRRRAPSVKPPESEFEPVLPPEAMRETKATSSKPKRGQLVAEVVIESEVAQPSARVKDEEVYLDRQAEEDRPTDIGTEWREQSVAEDLQYPDEEKSPASDLEELPEAVSDIAEDEQTVAISQRISEGGKLIRHTEEAPASTPLILRLLLILLAMGSLHTLYDYKTESALIGFCETGTKTNNVLEGLRSRRALVEACNRENRTLLYAPTETDSTDSVHSPLPIQTAVPDGEVAEGTEIVLAESCPPLPLLPIPRPDSCIQCPAHATCTSSTMVCETGYLLRPHPLLSFLSLPHTSTPKNPNAVNTYVLPTHDAGPSETGISQLVHTTLALVLDGVPGLGSVALPPRCVEDPRRKRHIGALGKAVESMLAAERGRRLCAGVGQSEQPGTEAQEAQKWGVEVDDLRESLRRKTSPQLMPAFEDTFNEAIQQLVAWGGVFVGENPEYVNDKYPRQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQX2</accession>
    <name>A0A2R6NQX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQX2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="14314" checksum="AC856604002DB50A" modified="2018-06-20" version="1">MPSWPKLETITLAFSMQSIERSDYSTRLSVSRCGWTCVVWFLNNLGRWPALRSVILAIQITDQSEEDLFALVTEVQAVEHALLRLDAAPDLLVVTADGRSLHHVHRRPLMIMMSTLHERGILRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR56</accession>
    <name>A0A2R6NR56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000925">
        <property type="protein sequence ID" value="PSR75117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR56"/>
    <dbReference type="STRING" id="98765.A0A2R6NR56"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000068">
        <property type="entry name" value="Chaperone protein dnaJ 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR75117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="43523" checksum="BFB4B0E015D9B5ED" modified="2018-06-20" version="1">MVKETKYYDLLEASPDASESDLKKAYRKKALRLHPDKGGDPELFKEVTHAYEVLSDPQKRSVYDARGEAGLSESGGMGGMDPQDLFSQLFGGGGFFGGGSRQAGPRKTKDLVHRVTVSLEDLYKGKVSKLSLTRNVICVKCNGKGGKEGAVRECDRCGGRGIRIVVRQMGPMIQQIQQACDECSGSGEIVNQKDKCKPCNGKKVISEKKMLEVHIDKGMKGGQTITFHGESDQAPGVTPGDVIIVIDEKPHDRFTRKDNDLHIDVEVDLLTALAGGQFVVKHLDERALVVNIPAGEVLKHDDTKVIHGQGMPSQRHHEPGDMFVHVQVKFPDSIPVESVPLLERALPPRKALEKFAKAHAEEVELNDVDPRHRERAEGGEPMDEDEGEPRVQCANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR86</accession>
    <name>A0A2R6NR86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000922">
        <property type="protein sequence ID" value="PSR75163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR86"/>
    <dbReference type="OrthoDB" id="2756453at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53601" checksum="F34F61D5408EAAEB" modified="2018-06-20" version="1">MRKEPKINGGKEKHLPWLHMLATNNHKHWRKFLSFLPSKTISHASTISTASAHIFCNVGECGNVELNIPLTWSSPPHTTPSMSSLMLPFELVDKIISEASSDHSSATLRACALVCETWRAAARPYIFRKIKILDESQLATLETLIGTDPAVGVLIRELIIQPRTEPERTPSRWISRFPAVLPPHLNRLQTIQLVDLFDFGEYCNPDFFSAFSAFASVDQLILRHCALDLRLVYSCVSALPNIRHLHVGTMLPVPYILPHAPPQLYAPQLLSIKLNVGSMYPMALEEILEWMLGSSSKDYLRSASLTTRIVNATAVGNFIDELGGLLQHLELDFVRFSASEIEYDSESTPNLSIASFDLRHYRPVMKADISLAKCTALRSLSFRGCNPTLPAFLAFLSEINSPYIRKLSLWATSSGADRAILPDFRVLVEQLDSRHLRGLEEVCFTYRGPLQRAFVLEKLQRDLPNVDSRGILRLVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS58</accession>
    <name>A0A2R6NS58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS58"/>
    <dbReference type="STRING" id="98765.A0A2R6NS58"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="100" mass="11573" checksum="7695106388288FEB" modified="2018-06-20" version="1">MAVPPTKEALLRLYSSSLRASRTFSSYNFREYFVRRTKNTFHEIQNESDPAKLSAFYNEQVKELAVIKRSAIVNQLYGGWRLVVEGLKDKPEAQLERSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSB1</accession>
    <name>A0A2R6NSB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSB1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="7756" checksum="62214267407CD41F" modified="2018-06-20" version="1">MSLDRSAHPLQLMRLTLSGRNSYRVHMPPGVKRVAGPAARAAMEQAGLLVNSHPKRKLSPSSLPDEEKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSH6</accession>
    <name>A0A2R6NSH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSH6"/>
    <dbReference type="STRING" id="98765.A0A2R6NSH6"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="82" mass="8744" checksum="B5F8CD52CE3E5E7C" modified="2018-06-20" version="1">MSDSYVSSANGDSLTANGTSKMNGSTPSLPQPSDTASSPILRKKLMGYVGFANLPNQVHRKSVRKGFQFTAMVVGTRRHASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSP6</accession>
    <name>A0A2R6NSP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v8757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000871">
        <property type="protein sequence ID" value="PSR75952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSP6"/>
    <dbReference type="STRING" id="98765.A0A2R6NSP6"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR75952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48188" checksum="54404422FA1BA469" modified="2018-06-20" version="1">MQNPDAELPPNPSTLAFESVSTRRQIIASYWLIVILAIPLWWKTTSIDRLALPSSRVRSLEGKEVSRGRKAYATKRNTYTLQLKFPVHVNVASEVAEYSEAVLKKEFTEWMHEHAEIQGLQIGFDSVDTTGPGSYYINIREHATKALVHGRHLSIGTSNENEEASKSLIPLGIADTLWKLLLPSASQTSSEAHRIVKYSPRIRLAFTLLNEDAAAGVAAFSWDIQEAIRRSPTSSNAFLLPQWGGIVLLNRGSPHLSTHLLHSPFATFQQQLLSLLGVPNLPPSVNSNGSEPFTDWQLDALVRQRARENAANAKETLQSITALVHQIENMPVGQDVKGDVQNALGALDSVFLVAKSSSTLALQYSSEALSLASRAFFNPGMLALLYFPAEHKYAVYTPLFASVAAPLMAAVIRELMAWKKARKAAAAKRESVDKVKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSV8</accession>
    <name>A0A2R6NSV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSV8"/>
    <dbReference type="STRING" id="98765.A0A2R6NSV8"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8039" checksum="A8E88424A6ABB8EA" modified="2018-06-20" version="1">MSMFAAPPLPATKLGRHRQLAPLAGVHVSPIQLGAMSIGDKWAEYGMGAMDKENSFKLLDAFYEAGGNFIDTANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT31</accession>
    <name>A0A2R6NT31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v8653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT31"/>
    <dbReference type="STRING" id="98765.A0A2R6NT31"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015337998" description="Peptidase M20 dimerisation domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="274"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR76155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="553" mass="59895" checksum="4918B103AA590FE4" modified="2018-06-20" version="1">MSSVFSRLLVSLLCSITLAHAHSTAQLHLQTALVPLNLPTEDYAACGQVAPLNPSESQRSRINVNLDVLYGRDSFKLRTFEALGGAIRIPTESYDDLAPVGQDDRWDIFALLHEYLEGTFPLVYQSLRVTKVNTYGIVLHWQGSNESLLPVLMTAHQDVVPVEPSTVNQWVHPPYSGYYDGTWIWGRGSCDDKSDIISQLTTIESLLKEDFQPSRTFVFAFGFDEEASGLEGAGHLAVYLKSRYGINSFAALLDEGGGFGKLYGGNVLFAGPSTGEKGYLDVRLEVSTPGGHSSVPPAHTGIGILASAIVAIESHSHDASLARSGTVFQMLQCAAAHGPDITTTLRSLIEKAASDDQALIELSDALVKMGPKFAALVGTTQAVDLISGGVKVNALPERVETVINHRIAEHRKFNLTLVSFGTNVTIGSEGAGHVILSKAWGTSLEPAPMTPISSSKPYEILAGTIKAALKSSTIYNSTAVVVSPSLAIDTQFYWNLTKHIFRYSHSTDDGRYNQAHTVNEASAYKVVALKGEALIDKIRFHTKFILNWDESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT58</accession>
    <name>A0A2R6NT58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v8610</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT58"/>
    <dbReference type="STRING" id="98765.A0A2R6NT58"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="189"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR76187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="47027" checksum="E98F56DBD01199C5" modified="2018-06-20" version="1">MVFKVADVSLAAFGRKEIEIAEHEMPGLMYMRQKYGASQPLKGARIAGCLHMTIQTAVLIETLTALGAEVTWSSCNIFSTQDHAAAAIAATGVPVFAWKGETEEEYNWCIEQSLAAFPGGQSLNMILDDGGDLTTLVHEKYPQYLKDVRGLSEETTTGVHHLYKMFRDGKLKVPAINVNDSVTKSKFDNYYGCRESLVDGIKRATDVMLAGKVAVVAGFGDVGKGCAESLKSYGARVIVTEIDPINALQAAMAGYEVTTMEEAAPRGNVFVTTTGNRDIITAKHFEVMPEDAIVSNIGHFDVEIDVAWLKKNAKQAVNIKPQVDRFTMASGRHIILLAEGRLVNLGCATGHPSFVMSCSFANQVLAQIALWTNPKQFPLGVHMLPKELDEEVARAHLEQLNVKLTQLTPEQASYLDIPASGPYKPSHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU81</accession>
    <name>A0A2R6NU81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v8326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU81"/>
    <dbReference type="STRING" id="98765.A0A2R6NU81"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="282"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="468"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR76729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="760" mass="84247" checksum="0587DB84C95C8635" modified="2018-06-20" version="1">MPTNVVHTTSDSPRLLLIDSYDSFTFNLASLCRRAIPGCIVHIIKNDEIPFPELVSLLDQFSAVVIGPGPGSPDEDKDVGVVKKIWKLADEHLLPVFGVCLGLQSLCIEHGATLKRLQVVKHGQISRIHHDRHDIFNDVDQVEAVRYHSLHVSLSGDEPLEALAWADDGEENGRVLMAVKHNDKPFWAVQYHPESVRTHGGGEEVLRNFWRLARKWSKRNRRNVHPWTHEAATCIGPPWPLIHSASNTQTPLPMDNHVSTRILEGPEWSIPAICELLGVDKESSDFVLLDSAAQPGRFSIIGCLRPTTPKITYKVGDGQVRIQDGHDHFRLEDVGADIWSWLAGFMQSRKARGGSEEIPFWGGFVGLLSYELGVNSLSATLSPRGASRRSVHSDVNLVFVERSILVDSKTGRLYIQSLLSHDDAWLSDMVSQFETMRNMMGSINSSEMEFESKGTVPTTPPNVALPDKATYISRIKDAQEFLFSGDSYELCLTAPTHISVPVPPRDLRGSSSWGLYKSVRTRNPAPHSAYLRLHPSTLISSSPERFLSFSRSPSVCQLRPIKGTVRKGPGVNRAVAEQALVGSVKEVAENLMIVDLIRHDLHGVVGDDVEVKQFCGVEEYETVWQLVSVIEGKLPHGTELDGNLDLGWEVLRRSLPPGSMTGAPKKRSVEILHSLEGQDRGIYSGVFGYWCVGGGGDWSVTIRSCFKHDDQGDTVQDEWTDWTLGAGGAITALSDPEAEWEEMVVKVESVLRAFHSSMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUS9</accession>
    <name>A0A2R6NUS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000813">
        <property type="protein sequence ID" value="PSR77113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUS9"/>
    <dbReference type="OrthoDB" id="3006153at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="20831" checksum="D2F4776170BF860D" modified="2018-06-20" version="1">MSDSPLLSTTQWSSEYVGWHDRSAPHRSPDDFTPTRDAFVFAVLRNAPADPNGFTLALFTPNIAIDASGRIFQLGDTDFAGLSALARHVLTLPQTGSFMNAWRIVRPITSQPIERLFVPDSSGQLVQTSVQGFEKEHRNQLKTPVGQYTELPVVLSELFGLITEARAGYQKGVEDSSVITKVKAIVEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUZ0</accession>
    <name>A0A2R6NUZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000804">
        <property type="protein sequence ID" value="PSR77253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUZ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NUZ0"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="169"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="422" mass="46441" checksum="FC46270B6C5E52AB" modified="2018-06-20" version="1">MTSSTNQHLHPVALAENLLQLVKSLYPSSETSIADDSKESYIAKGHLQSLTGQLLRSVLGPADYTVALAESCHESAALQLITSLGVADIIGDGALSLHELSQKTNVEHKYLSVTMRSLLWHGYFEEQGEFGTEVYANNAMSEVLKTSNDATLKDAIGMIGDEGFKGSSYLTEAAQSTDERSALSHAFGFTDPVFKWMASPEQAWRGQRVGKAMQQLHTMANGNVTRDYAWDTLETPVVDIGAGIGSLEMILLGQEHRGLQFTLFDLRQTMENAEKAWKARYPSKLKQISFVGGDFLAESVEETNIPQGQPTYIIRHVLHDWTDEQVVKILRNVRAAMLSGRSSSDKAGHLPKLVLCEMLLRASSSRFVHTTSVQLLSLNNGITRTESHMRSLVERAGFRVVAVHELRAADAIVEAIPDITEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVZ1</accession>
    <name>A0A2R6NVZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000774">
        <property type="protein sequence ID" value="PSR77818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVZ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="252" mass="28574" checksum="C9AA9E6CFB4BBBB6" modified="2018-06-20" version="1" fragment="single">MYKIFRKLHLRLLPFLKGFAWPRRHKAAATQKQPSVQRAFGIADITLSILERLQNKDLARCALVRRDWADIVHDILWKGRVDSGVSIRPILGLLDEFYIEHRMARLSGALSPTSWAKFNESLYAGHIGVLDLNLRDLNCNSWFLAAMLDSIHSPMKLPALNKLHVTVSQDAIELQLAMKFFSSNVTHFVADIARGYASATGRRHHARMDSLIPVFRDPLDPQTSTLSTAYPLDEFFAAVHQQMPHIVILAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW26</accession>
    <name>A0A2R6NW26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000763">
        <property type="protein sequence ID" value="PSR78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW26"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="9568" checksum="B29A0D5C036FB13E" modified="2018-06-20" version="1">MAGGFLLREPVHPHASTGTYRSDTLPDPPLPALYYRLLSQKLSNGDSKAASLAGLLGSTTNIQHAREADGLARNLNLSHQQNKHFFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW51</accession>
    <name>A0A2R6NW51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000758">
        <property type="protein sequence ID" value="PSR78105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW51"/>
    <dbReference type="STRING" id="98765.A0A2R6NW51"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="208"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR78105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="354" mass="40138" checksum="C8459C3594919939" modified="2018-06-20" version="1">MVIRYRSGQKLNGIIYMHRISDCRLSGPSRRIFKLFQRLCGEEAFGNVVIVTNMWDKVPPEVGAEREAELETDQYLFKSILEKGGKMFRHNNTVPSAHMILLHLASKSPVVLRIQKELVDQSRSLAQTAVGVELNRQMSDVLDSRAGIFANNPAMLIREKAEALKQTMEVIEALEAEKAARVEAEKELGRLREEAEKPKDAGMQNIVHKSVWCDGCKTKPIFGVRHKCLQCKDYDLCTTCLCSPKLRASHDAKHTFFPVDTPKDLTAYQAEKLKLEAENPTHLGFQCDACQVRPIVGARNRCMNCRDFNLCQTCVSSRQVRLQHDKDHVFFPMDDPQKRDPNVPVTSFGMRPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWI1</accession>
    <name>A0A2R6NWI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWI1"/>
    <dbReference type="STRING" id="98765.A0A2R6NWI1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30564" checksum="75876F992E7A4BB9" modified="2018-06-20" version="1">MASSVMEGMFALPQPSLSTPSGQTEDHPPSITLSEDSQTLQCLMRLLYADMGPKLWDLGTLNKVLDAAEKYEMANVTETLAIHILPQYIKENPLHIFALASRHNLTDIITKAASASLHIPFPKWDSPELSGITGAAYHKLVVYRQRCQDAAVESLTKSASQPQTRAFGLPITTPSFLQCSSCPRNPQGILDRYGNLPLWAIDHLDRAREALIKCVDGEAVTSLAILERTITKLPPLHRMGSQGCQCAATAPASLITFSRGLAVKMNQEITKVSVNISVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWM7</accession>
    <name>A0A2R6NWM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWM7"/>
    <dbReference type="STRING" id="98765.A0A2R6NWM7"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="182" mass="19779" checksum="1A147B0C068A980D" modified="2018-06-20" version="1">MTTDSENLLGPTMRSAKGNVPQSIKDSLAEWYSGAADLHRFAAPIARRLEATEMSVYDKTEEPGKKEAKMVFEIDVTEDMCNFGNSVHGGCSAFLIDLCSSLAISLLATQEPKRNVHVHVSLVLNTTYHAPAPLGCRLKIVNTTMALGGRVMTARAEIYDITHNRLVASGVHIKMPPSAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXJ1</accession>
    <name>A0A2R6NXJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXJ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="116" mass="12286" checksum="EEA292640CC6CF56" modified="2018-06-20" version="1">MTAFKVPLEGNVPEVHIHLQDTAFSLLSYSGVCAWHLTQKRTAETARPSEPSLGDGNYISSIVRQGSDDMLELDGAAVSNFSQALSGPSASGMGSLLLPTLRLCLALSPLLALFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXP0</accession>
    <name>A0A2R6NXP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000695">
        <property type="protein sequence ID" value="PSR79449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXP0"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="35"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="840" mass="94461" checksum="55ACEF058D512DD8" modified="2018-06-20" version="1">MGPTTSEQIRRMVLRTTSTSTSFASGLQEEKSDGWKVLLGAMEQSDQKTLDRWKAEMDNLLIFAGLLSAVVTAFTVESYQWLRDDPAATSVVLLAQISDKMTSFSVAAGFINSTDPNPRPIDTSSFLVPDAVRINMLWVLSLTFSLIAAFLALAVQQWLRHIPLPEDMTIRQSTRLRQFRQEGLGHWRVPMIVSFLPILVQVAVILFLIGLLYLLRPLNHDIGLAFTVVAGSLLGSFAITAFLPFYYRDCPYKSSFFPTIVYIVQPIAKTILYLGLFVVYVVATVSVFSICLGLATAIVAVALAVLLVGLALFPVVFTFSYLIPAVYSCISRCLHTVFSPIVRCLHPVLHRVKGVFSPIVSPIHVALNSLWELIRKGLTGLKALLRRVFPFGKHKKGDGESLWSIAVGLWERFEEARKNKQEMVNNKFGDPEKLWLNLELKKMMSGRDVCNNLDESALASAPLAVARSESSFNIIKECLKDLALPKHRTLCAFKWAAHHLGVVSEAILEDMCDYSRFSGINPRLLAKVDKVFAERFREILWEALPTNGQTFFEGSKNTLLGIMILLMETTKFRHEEPDHPQFVQKYMDLLMKILQAQTTESLLSYNVRRYGRLPTALYYEGCVRHKHSFSDGDVKHAVNWAHQQLTTQYEECTLSVLELIFGSAAIALIAMTQSRDETFVVESCHRLLPALRAYLESNRQSIQYKAKECEAKTSHHVRLVFQHAMSSICDSLSRLPQSHLYSDIRKGDFEHDVNLQSDVEAIRSTLAELLQEQKLFNDVLWEVKFPEGVPVPTHRTAVPLLVKKLVETSSAGSEEKLASTEEDNADSKKAEALDIVTLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYQ1</accession>
    <name>A0A2R6NYQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000644">
        <property type="protein sequence ID" value="PSR80663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYQ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="8830" checksum="64A06907B6A74732" modified="2018-06-20" version="1">MPRPTGIKGAPHFRPGTWIAKTRQRCCDCSIHGGPLIALAGLVIKEATPQPSQVLLASTSPGRWGTDLLGPTERAGLGVFPVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYQ8</accession>
    <name>A0A2R6NYQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v6709</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000652">
        <property type="protein sequence ID" value="PSR80502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYQ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NYQ8"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="94"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="229"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR80502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="393" mass="43293" checksum="B7E65B3D3A6AB0BE" modified="2018-06-20" version="1">MFSGRCGSSLLRSLPLLATRPSTTLPSANAFRANVSSRTFASEVNDALTRTDPLYKTYKPITPSIRHLRLPISAHLFKGRPLRQLTVPLRRNGGRNNHGRITIRWRGGGHKQRIRLVDFIRSEPGAHDVVRIEYDPGRSAHIALIKNRNPNADGGKVWSYILAPEGVRAGHVVESYRQGIPEGLVPGFVDSRDVRGNALERQAGASKNEGTQTTSLGSLALGVLRSITIKPGNVLPLRLIPTGTTVHNISLHPEGRARLVRSAGTSAQVMLHEGSGKYTHVRLQSGEVRKVLQDCIATIGKVSNPLWKNRNLGKAGRSRWLGRRPRVRGMAMNRCDHPHGGGRGKSKGNKQARSVWGWVSKGVRTRKPGPRGPKNSNKMVIRERPRGKEKQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZC6</accession>
    <name>A0A2R6NZC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZC6"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="10926" checksum="71C57AB9F5CEA208" modified="2018-06-20" version="1">MVGTLEPILISRFLLNLRQVGSPEINSQEAFNSQFSVPGFRVPSLASIIGNMGEDLDHSGPAEEVDDETVNIPGSVQAEDVEAENTSGNGVQSEEVAVPETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P039</accession>
    <name>A0A2R6P039_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000602">
        <property type="protein sequence ID" value="PSR81961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P039"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46179" checksum="67827FB935EFC3AD" modified="2018-06-20" version="1">MATTVLPPELDDMIIDHLHDDPATLGRCALVCRSWLPAVRHHSWSTIRVTANADDLARLSSLLTESPDISAYILNVVVVQKESQGQPSDDDLQLLHPTLSTLSTLMKLTTLTLDGLCFGTMDGRERNAMSQISLPLVKKLNISTCSFDSFGDVSRLCATFPALSDLRFDGVWWGKWLVDHRVQEDVDEQEPKDIVPQLKLRDLDLGSCFSRDKAVDWLLKSLAHGCVEALHLPLIGAHDTRLKDLLAFVGPSLQHLDIGSPSGSTSRIRYDNSSNTRVPLASHLDLSSTTSLRTISLSVPTYRDASFITQWLIAVLSQVASPVLEEVRFAIYPILKTDVADAESRLGGFGWVEIAELLRGPQFAQVRKIAFCAGRRTDYLQIPSAFAALDNVVPMVVSKIFEPLRHRGAVICFEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0M3</accession>
    <name>A0A2R6P0M3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0M3"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="173"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR82564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="33652" checksum="4B1CFAAEEE79C696" modified="2018-06-20" version="1">MNERIRQLEDALAILQARCSNETHPLLRDELLTTNAEQEEEECTTEVTPARPVDVIDTFGTLSVSEHGVSRFFGPTGGAETELDTPPSSPPVGTASPGSGRDSMSPPITGELTRFSASFPFTPIGSPSEVQDLIEQYLPAWARATHLCEMYLQNAAWLFRGITRHQLMVEMLPIIYKRPVSADTPSSQDFSGPHDLALIFLVFAVGSLLDMSQEPYSAEGEHFHHIARAALCLQPVLEKPSVVAIQALRLLSIYTAMAGKELRGSETTMETTWSLLALSAQLAQSVRLIRLVSTEAPNSSSGVLDRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0T0</accession>
    <name>A0A2R6P0T0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000573">
        <property type="protein sequence ID" value="PSR82820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0T0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12326" checksum="177BC04CAFEDF45E" modified="2018-06-20" version="1">MSSSMQKVYTFMLRTTHILHLYRVNHTAPDSAIALMAFLIKRNKVSLYDAHIRNGHVSYNYIKKALNLDHKYHGLQINPSKMEEPLCKACVKGKISCAPIQKEHIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0W1</accession>
    <name>A0A2R6P0W1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000574">
        <property type="protein sequence ID" value="PSR82815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0W1"/>
    <dbReference type="STRING" id="98765.A0A2R6P0W1"/>
    <dbReference type="OrthoDB" id="2801422at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="452" mass="50635" checksum="72A3085608930B6A" modified="2018-06-20" version="1" fragment="single">ERLFECFQEFIDATSNAAVENAVCGVCARELNEREAGMRQVAVSKIPNQAQLVPVIQHPAHDLYNECLLEPTGIIHNLNGEQVVNICHDCFKHLSSASDGPPHLALANNMWIGCIPWELQVLTLPEHLLIALVHLRIYIVKLYPKDKDFRPDPTTLQRGMHRTSMGLPLCWKLEEYPEDDVPIEIADVICQTNDTGVVDEENGGFVPENEDIGVHPDLMKGIVKDDANMLHNPEAGTIEDADDPDVIPFEVSDLVDTNLTKMTSAELMMWGLLNLWNKGREGGYSVRHGRQPVRNLLPRRQPDAEGHSDASDGEDNLLADEDTLNYFERAFPGPFPYGCGGIEGARPKVIDFPTHIHWALQYHNRRFCKHNTFPFVCFGIKQKRQALAHASIQIQRQDFKHDLQIMADITADRLKLAAEKEAQGLPPSDPAVRLLRKHVQATTGCVVGTDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1A7</accession>
    <name>A0A2R6P1A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v375</name>
        <name evidence="5" type="ORF">PHLCEN_2v5823</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000031">
        <property type="protein sequence ID" value="PSS37774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1A7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1A7"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR83174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="205" mass="23227" checksum="DBAAAF7FC1B28B32" modified="2018-06-20" version="1">MWVSKRYAERNWDRRTSIFFFVVAGAALSVGIYTLTTIYIKDRFGSGYPNDPLSFAVTFGEPVAMRVSDTAHFDLQSQEGIDEFAHALPSGGHLVYVRPDGDGSDPQPYTVTLFHQLRCLDVIRQQYSKVPSAPPPSLLHHCMNYVRHTILCRPHLLLEPAVNSQGTESREGGYDAVCHNWEAVYQEAERNYEAYTNWSHRASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1F5</accession>
    <name>A0A2R6P1F5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000561">
        <property type="protein sequence ID" value="PSR83379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1F5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7610" checksum="1E420AAADDD274D1" modified="2018-06-20" version="1">MVMKLEPKIYMVGAHALGMDKARRAVRNFPNPLKGDKIALMRPPMLFPLSNPASHVGTLGAEAANITPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1K3</accession>
    <name>A0A2R6P1K3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1K3"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9564" checksum="7D53E9FC71F3773E" modified="2018-06-20" version="1">MLLILASAGCLAVSLYYTIWGTLLRRASLPPGPQGLPFVGNLFDLPNDYDWLHWATFKAKYDDIVSIRLTVIQTDAENGIPVYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P229</accession>
    <name>A0A2R6P229_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P229"/>
    <dbReference type="STRING" id="98765.A0A2R6P229"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR83464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="21698" checksum="04225C448A917F9C" modified="2018-06-20" version="1">MGTSILTSCSRQTFAFSRDGGLPFSRYLYRISPRTQTPINCVWASVFVSLLLGLLAFAGPSAINAIFSLAVIGQYVAFSVPIASRFLGGIAWRSGPFSLGKMGYPVAIVAVLWMMFSIIIVMFPTTPSPTAQGMNYTVVVGGGWIVLCIIYYYFPVYGGVHWFKGPMANVELETESLSKVERVSVSLTGEKEFGEDSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P290</accession>
    <name>A0A2R6P290_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P290"/>
    <dbReference type="STRING" id="98765.A0A2R6P290"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="9696" checksum="BCD613AB5C5649B8" modified="2018-06-20" version="1">MSDYEFESEATDQDEDVPLALARATKASKGKQQDEGGYRIRGALKVPRATTLPTQSLLHQLVQEDISLDAEYQRGRRRYTSYTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5G6</accession>
    <name>A0A2R6P5G6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5G6"/>
    <dbReference type="STRING" id="98765.A0A2R6P5G6"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR85838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13603" checksum="4F3F4109182E6C56" modified="2018-06-20" version="1">MPKVASGKAAAKHKFVIDYSRPAGDGVFDGAAFEKYLHDRIKVDGKAGQLGDNVKITRNGDTNVTVTSSIPLSKRYLKYLTKKFLKKNTLRDWIRVVASSKDSYQLRFYNIQTDGAEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBT5</accession>
    <name>A0A2R6PBT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBT5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="167"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="488"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="750"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR88592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="970" mass="103554" checksum="A42EB40E7C47352C" modified="2018-06-20" version="1">MDPTSRSHSLAAPVTQPLHPHMLGQSQQPHVQHLQAQQDVQQNAHTRNRPNGYPPLYPKPHQPAGSSPANTSGNGATPSPPSASLSLASVTAINGVNMNGNANGVAYSGDHTIPDAVYPNEQEHGHAHGHHHHDHSSSSTCVPSLIPPGIDPAHVDMRTFYPYQPNEVKHRKRTTRQQLKVLEDVYKYDTKPNASLRKRLAEELGMLPRGVQVWFQNRRAKTKTQARKAEAVSSLHAGTARAPIDLTSPSSPTTSTNPSSSTSSSSPNPDGQGELSLSTPPPETPSPAPSPSPTISLSVATGDNGWGDPEDSFPTLSSSFSGSSSNFLLGVPSAAELLQQRRPSLPMLRSAPSLAPYHKQSPGSALSPFIAHDSNENGGLHAGGGFELDQRRRKSIGANMKGLSRHPYAHLAQGINASLYGKSEAGSTLGPRRIRHGSMPHVLQPHQTPPPYYLPGPQNQPHMQRRPAMAHRLSVPAVHYPTLTSAHQRSASGYPYNSPGRPPIPLPPINASAGLNESYEFPPPSLSAPSTQPHSPSTASPPPISQSFVNGGLNGHAAALGRMGMHGAYAISSRSVPAPIPGPLPEPSFSFGMASTSPAIANASPSSSNTSLTVTHMEGGEGDVEDDASALSSNFDPYSRWNSLASMAGSDSSLTSYWSDAAQNGKESGENYDAARRGSVVSGVLPELFGELDVNGNGGSTPQPQPLTDSPREIHVVAPSSPEERRRASVGGSPHEGEAYAMQTQSTFQDQTGFSPHSYSPHQQQGVYPPQEQSGYVLHAQHNGYPPPHEQNRYTLDEHSPYSSHDTGSYSPSSTSTVSAGNLKDGSPTMLRQSTSSELAHALQARPISGTEDVIPNHGAQLLYPSDFPDGPGPDHLDHNNQNQPHFPVNSLSPKSVHYSPEPFPNSQSAYYSQQQQQQQQQPPPLVDYPYDVYNGTPMFPSGAIELDHMCVPSPMVMENMQGGDYMSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PFX0</accession>
    <name>A0A2R6PFX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v4917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000498">
        <property type="protein sequence ID" value="PSR90355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PFX0"/>
    <dbReference type="STRING" id="98765.A0A2R6PFX0"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="97"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="349"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR90355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="453" mass="50549" checksum="DCEC9BD363883E08" modified="2018-06-20" version="1">MAAFVFSVFGAQPLCILGVTGPITILNTTIFNIIERQPNPPNYLEFIGWVYLWGAILHWITAALNWCNFLRYVTLFFCDTFGFFTSWVYLQYGVQVITTQFRTASDTEAFVGIILALIMLVTCYLFRIASHSTLFHRHVRRFLADYGIPICLVACSAVAYWGRFNAANPATLPIAKAFEPAGGREWLVKFWRLEAKWVGIAFPFGIALWVLFFFDHNVSFTQPNQSLMAQGSQFPLRKPPGFHHDFFLLGITTLIAGLLGIPAPNGLLPQAPIHTYSLLVMGAPQKKDIESSIEGRPSKESEGEKKTPLAPVRSRLSGVHMPQFQHEPEPDPHFAQDTEGLTVAHEVPVAVVEQRVSNLAQGALCLVLLTGPFLHILNLIPRGVLAGLFWYMGADTMQDNRITHRILYLLKDKNLTPVDEPLRKVRKSRLLLFLTLQLAGAGTAVGITDTVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG01</accession>
    <name>A0A2R6PG01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000495">
        <property type="protein sequence ID" value="PSR90479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG01"/>
    <dbReference type="OrthoDB" id="2634326at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="566" mass="64122" checksum="FCEED0FC4B9D2926" modified="2018-06-20" version="1">MDGLVGVDTPDRKFVMTSPNVAWVPAPIYGNISVKLRADGQFGVEDPLQWPQLFPTNPGCFHLAAIRRRPHGVSSPSHKFYYIFANVTIEDFVPINTDESRYGTLSVRWQEGLKDLMKIVDDRLTRYQAYTKAAPPDTIRFLVTSMRDVAFVRLDFPSTFRDIRLQTVSCQRLWLEATAWLDWATILWPAFKAGLRLDQPVPAAKEMYMGAYTADVNVVQNLAAAGLPVWLLRVPAELSKEVVVLKEASTVIFPSHINTEIGDFAIDPIFMDVGRKPHPHQREAYADPSHPWIPPVIPEWSHALLAIDLSISPVNHWLYWLPHPTLIVGSKTEENQILSLTTWLQIRQGWLSVLKNRPYSIQPVSAQHWRVCLQAGKHMSTGDTHTAVFMRETFELFSAILGDNYLDSNEPFTFFGHEFTNPPPDIRPFIIWDIYEVGFQVDLLELDRYQTPVCEEATRATLLGKVFPGREFLHLTALPIRNEGLAAVFLSARVPALEALRSVMIRWKDVPPSFLQIPPLPSVRASASNLLAQHESSIINTYTQIFHRCAGRAPFVPHRIPTSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG98</accession>
    <name>A0A2R6PG98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG98"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="230" mass="24230" checksum="2C9A0838783D3289" modified="2018-06-20" version="1">MFKSMLLALFVSTVLAVPAVKREDLCDVHSVTLDLPSSETGTPLATPLASGPVFIGLGVGVQNYTCTTTGTYTNVGALAELFDISCLSPSNYNNVTDAAWYIWETAPADLTAAEVIAALAASPFILGQHYFITNPITGSGLSPKWDFTSASEAGHPDAYVVGAKTGDISSPTDPTVNIDWLSLSGAQGDLASQIFRVQTRGGQPPASCTPGSDEIEVRYASQYWFYGGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ93</accession>
    <name>A0A2R6PJ93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v4745</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ93"/>
    <dbReference type="STRING" id="98765.A0A2R6PJ93"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR92215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="226" mass="24644" checksum="6E859857FB8AE5BA" modified="2018-06-20" version="1">MVVQGLGDSGHGWQPVATMFGSDPAMQHIKWVLPHATRLADDVATDRPNMPVTANGGMRMPSWFDIIQFGSGIEDEPGMLKTVRLLNEIITAEVDAGIPANRIIIGGFSQGGAMSLLTGLTTERKLGGIVAMSAWLPLKNKIKAMVGDHANKLPIFWGHGKDDPLIRFKWATESIDFMKSDLGTQEATAEDNTGLEFHAYDDLVHSANDKEIVDLQVWLQKAIPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMY6</accession>
    <name>A0A2R6PMY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMY6"/>
    <dbReference type="STRING" id="98765.A0A2R6PMY6"/>
    <dbReference type="OrthoDB" id="2804719at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="352" mass="39044" checksum="755185E20A201EEE" modified="2018-06-20" version="1">MSDTAIRERVVHILSSTLNGCLREMGYFPGILQLLDELRVENANLTERNGKLHIDNVNLSHLVERQKGYIAQMRHVNGDLDPPLVMLPYSMHHDIRRTSNGALSRQGHTASTSALEEAHEAYPPDPRSHTIISIPSAPLPALSGANASDHARPQDPATDPVTTSVSASPVASSTTAYASPELHFPATPKYNPDTTHVSMTTSDSRIASTSARLEVIDLTADEVDEATSYDVKLENRRSVTRDQTPPLNSIDQEGAFLERETRLPDKNADQSVPELVVPMETETPDHLDRALEVAYQIDDNGSLWCKMCKWRFDRGAVRDAPTDFSSTSREERVKHCREEHPVGWTTILKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN53</accession>
    <name>A0A2R6PN53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN53"/>
    <dbReference type="OrthoDB" id="10399709at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR93823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="175" mass="19954" checksum="3ED13DB36F2F8437" modified="2018-06-20" version="1" fragment="single">MEETLLERADEQTIRTWIKELDGQAVKLTDNKPQVFEVGPDGTVLVADANVLSRINQYRTVRGLKPGIWRTRWMDEEDDHGEIIHWQFSWVSTGPLELDNLPTEGTYPQPTFVPLTDWQEVASFGVDSGKMSIMDKNMMETYIGLTGDQRLVIEVSQDPFSRRMGYQGVLPGGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVX8</accession>
    <name>A0A2R6PVX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1544"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1678"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR97596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1734" mass="192494" checksum="8150B84D1055876B" modified="2018-06-20" version="1">MSDDLLNNQGTDYAESTFSSGSHVKSIRAAKDASSRPQPLNLTGWPEMAETLRQVDEDKVKDYKEDIDTLLVFAGLFSGVLTAFLIQSSQSLSEDTSVTAVTFLRQISAQTSSYSFNAGFFNSTVHPLAENLPPFVAAPSAVRINALWFASLTLALVTASFAMLVKQWLREYLSAESTSAKARIRIREFRSIGLQDWKVFEIAAILPLLLQISLGLFFIGLCLFSWSAHAGIGYTTTPIVIGWAFLFFNATLAPMISARCPYKTTLLKRAMQTLRRMLCSSRFLRTFYCGPMKGEGLYPLEERDAAADDGIDIAILTTADAILLDDDLLATTIRGSLQETRAKPAEIMSFVLEAVRQRLQETSSFTKLTHFLDLSQLTERAWRALINITAQTLILDDNDESPVNLSEDCREDAITIILSSPGNFLTPEADNALASCMRTALVPTCRLIGLRHAPQSLSHILQRLRNTFRGLNTEDTLRALFNIVLPNGDVCDAAHGSQSHTFLELGDLLLRHTGELPYTDIGNILQDCVNRGFLAMDFVRWTPSTINIALVIAVDAVRADDKLLTAVLQNVSLDDGAQLSLILKLCMHTLCIPSASLPCIPQLHYNFNLSVSRWTIIVKTVAQILLQRMRQYDEECQWDDWEKDAITIFVGFCDFPLPQIAELALEFCMARSPAATSQVVATRNHSTDDYLGLPHIFQRMRTSLSQLGAEDLVQSTFTLIHENPNFCHPGCTHTSNDLAELLVSHAGRLPRGLITDILLERFNLSQTQHIDELTTPEYDIQLDSDIDLFFELFVSKLLNSLPELLSHPRYIIKLAIRALQRRIPTTSTTQIIPIFSESDQPPPEWTAIINIVAQTLAHCRQPSRTPWEKDAISILLCCSNCPPTPDVTHALQDCMLVAPEDTSSMITSCQLEGFTSSQWFAHVFRRLDHVFDLLRPADVVRSIFIIVERHACNITCADKHLLLVDLLHSHSAFLPMRDIAQILFRYTVKYISQIHSKQTSWSSHMAEILDVVGELFLDDNVLEETVFPLLGRTLTRPSFVMEFIFDILRRRLGGHVLDLLTDDKTKSVDLSHLHERLRIKIVEIIFCAMTIPSESAHEVLPSPRWLIIGRNILSSFFSNPPGSVASDAESEMHSQYMTKMQTALSIVIAPYTEGHTAFVDVLTRLRTILPAVFDAEETMSFILALMILHYDCKDHTHLSLEGLLFSQYHRVPFAIIEVIFSILMDYMKLALYLRPSEPSSWRSPGIQKVQRAIFAVAFAHTTLRPELVTLSPKLMSVSMDSVLASIQSAVKFQPDGCMTAAVGEGSAQRILVDGYVFGVAERQSILQNLIEVTHHIMEGSHDKLKYWGEISAVKLCHLIIRLLHASHFSSGQSVPPDGQFPQVDLWAILFAQLGSALLQFPIQFPDLDNENKLLHISLAGDCLGRLEELDGYLCQIKVHEYRQWVERFQSDKQKSIFPDDLFVQLATFLPEDIALDYKRVRLIGELAQGKGIESVPTHGETGDLLSTYLEEGENGESSRNGGSASFELTKVTSGVDEMSAIQSAIQSTERTPTLIAPGELDGELDNSNTSHGDNSTLTSDSQGISLNIPEAEELTATTREDSYHDDGSHDGNIYNSAVPELVHTAGVTPLDTEEPTQGTTIQVADIIAPVPVAEVADTVEGIQANEGPAVTSQGMRVVGEEPSSREQQESPAENVSVSRPSVGGAATPQRLHDLSGNVSIESETKDSYGVSDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7E0</accession>
    <name>A0A2R6Q7E0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myosin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000388">
        <property type="protein sequence ID" value="PSS03321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7E0"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7E0"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="900" mass="97725" checksum="09E0374B1C9C195E" modified="2018-06-20" version="1">MAQPIFDEHPLHEYFRETGETAEPMPGGNPELVAEVGVDELKSSALAKFVLSVSDRIQIPPLVTEGISAISSSLFSPSNFKRPTTSFAERFKYDVISSSLLSTSLTATPHPSRRSFSPELPGLLDTGPHSRTSSTTAVEESHPSPHGSPISASDPGAIPQAVAIVSIAVLALAIGYEFLAMLLLAVALYVARAVSPTSDQNDVATLTLDAVSELIGAGNVWDSAVNEAMMIVEKEERTPSAYYGPTSPLSPISSLRVAIQSSLHTTQSQCDNVRKLLSALTSPTQLSQLSEMYAPASPIKSSFPSSDHPRPLSDPVAAWRNRTTLPANASPLNKRATWNGSYASMALAGRQSPLSPMKKREKTEGKRRSELTTFFNLNDAPSMTVSAPPSPLSQRILQDVQEEEDHSESELPYMKDDEVFGVAALDLQRKRRTSAFDVFGASPPNQASHLRHTPGHSSHHSLTSLSSPSRFTLLQTNRHPLSLSALHLALHGALSAKRYACAHLLALRFEEDADDEAYWEDARSVMALLTSTLTDASSRLMSALDDAEKRRMKDERPSTESLVGSSRESSYSPEPQRTSKPGRPTKTMAEMVSFAPMPNHLTRFAAHVDAISSALSDAREHLEQCVALLRDDSAKDGNVSMMPAADGSLQDLFTEGDENIENHALQAYDRLRKELGYALRECERGRERLLDAITASHPADPPEEEDSDLSSAVPPLGLDTSSDESTGLESPFAFPPKEGHPDSSTIVVEPSSTFVDDASEHLLVTASSHHLPPPGIEQVFEADSGGGTPFTRERSKMSREERIRLTKARRESGINGIESGLSSEPEPGSTREKWGPGGEVVQELKDVIWKVGEKRRKMTELAVPPHPVMRIVVDQPDEGSWTQENSIRLGAPDAEEKDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7F7</accession>
    <name>A0A2R6Q7F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000389">
        <property type="protein sequence ID" value="PSS03313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7F7"/>
    <dbReference type="OrthoDB" id="2797511at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="363" mass="41240" checksum="3D358F2A66A2B0B6" modified="2018-06-20" version="1">MSAFEPATIRTVIRASLQPNERARFDKDWDDTVKQRLTKWLQNRPTQSRDVEQLTWEANIVAYVNVLYERTKIHGNCKRDTEAPALKKNIPIYGPRFVPPSYLHVQKRNPVTPLIKPSVLFLKPLHVIHPFYYGNLRKCPQCGSSEGVSWNSWVNTGHRELYGLRQGECALGYQLRCKGCTTGSTMQGSGDSDSDQHCFATTSSAFWRKWEHWNIPQLHLLEYKQRELEYLQAFESRKVNALVPVELKPFKAPAILGGEALIVLDGADVEEDNPYGDKSISDDFISDIYLDFDKRARATESQEYLRTLSGITLSLDATFKSAKKATVVDDKKQRVCLTKGGLLSVINERNEILAWVCIASVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7K4</accession>
    <name>A0A2R6Q7K4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000382">
        <property type="protein sequence ID" value="PSS03730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7K4"/>
    <dbReference type="OrthoDB" id="3006363at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS03730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="496" mass="52687" checksum="05E9E986F6F3263F" modified="2018-06-20" version="1">MAQPDYRTLYMRKATQSARRRRGQQQQQQQQQQQPKGQTMGPTKMKSNMMDNDSASTNPPTNFPFKAMDSNGDITSSSQQPSATKSSNPFNPGNGGSNSGSSGSPGNSSNGGSGPSSNGSSNGNSNGSSQNTKNGNTDSDGDSDDDDDDDGDDDSKPNNGKTNNDTSVNTDPGCETVNENDGRLQYTGNWTLESKDPNGLYFTSHTTTTAGSQVAITFNGTSVTVIGVVHASNITDPPSQAAASYAIDTDTPIQLPLPFTDRDIPNQQFFESADLPLGSHRLVINVTSNGSQYTLSSLKLCTTVTNSVAAAIPPSSRPTSRISDAAIVGGVLGGVAFLFSVILGFILVHRRNRKARGTRTAHSPILSWLQRRTVFTSSDSIMRNNPSNVSSVDPFDKNPAAENLKHAESIRDSASIYSLDKNLPLPPVIPPTPLSQIAVLREPARPESSFSNFSYAPALTLPPVSDHALPASADPEGHLSLPPHPPLSVMQRPQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB85</accession>
    <name>A0A2R6QB85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB85"/>
    <dbReference type="STRING" id="98765.A0A2R6QB85"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="19898" checksum="C575EB9BF2AD6A0A" modified="2018-06-20" version="1">MSSKPVVVVTGTSKTDATAFGHAISTAQKTYGHIDSLVLNAGVLEPTGKITSPDLNLEAWKAHFEVNFFSQVTAVRTVLPWLHKSELGGKIIFVSSGAATGNTHGWAPYNASKAASNSLCSLEGKMRDEDLHKFIRDHKEGNLVDPEDCGHVIAALALKAPQELTGKFVSWDSEECREYWDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEC9</accession>
    <name>A0A2R6QEC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000364">
        <property type="protein sequence ID" value="PSS06495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEC9"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS06495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="46771" checksum="E3DAA9E34BBED185" modified="2018-06-20" version="1">MVDILVLGATGYTGRLIARYLNAHPERSSFTFGIAGRSKSKLASLKQELNLGDSVQVFHVDVTKQSDVDEVVKATKVVINTVGPYWRWGTPVVKACAEQGKHYVDLAGEQHWIQDIIIELDYLASKTHAIIVPASGFDSVPSDLAVHLSNKTLKALSGSDTDIEESVSAFKLAGTISGGTVQSILSAVTEVPREKMRIAMLDHALSTALKGPRSPPPKLWYTLPFSYPTIYGGLFMMASGNKAIVQRSWGLNENRSTNPETVSQDARIHAYGPKFKYTEFMVMPGKLSSIMLSLGLALSMVCLLIPPFRWLFTKLMPQSGEGPTERQLKDGYFHLTNVTSSVASPSKPQTHVRTVVHGQGDPGYLLTSIMIAESALAILLSHSELPQAAQEGGVLTPSTALGDVLLKRLESTGRFTFESEVIIRGDETND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEI7</accession>
    <name>A0A2R6QEI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside diphosphate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEI7"/>
    <dbReference type="STRING" id="98765.A0A2R6QEI7"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="370"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS06547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="504" mass="53745" checksum="90AE7D2CFDF96269" modified="2018-06-20" version="1">MSSPSSPTFVETPVEVHSPSRHTRTVAIIKNHALDHRFDIELRISEAGFEIVKERQMEFDVETDPDTMYELFGEDYVSFAEGPVWVYVLERRRAIEVWHTLMGDSDPEVARQESPNSLRALYGISREQNGVMGSPDLQIAETQIASIFASSPPFPTTDLPDVNSDSHTSGSLPSEDYNGLITSPRGPASERSSGTRSSTVNGQVNVNGKPPIFRARTVPATNVKPDIVPRMSRAAALRVGIDIDAGKPRRLIATAESLAKTFSGVPGHKRSETIHVASTAPPTVAPRMTRAASLRLGQQLEPKPKVRPSISTTNSDTFEGVPGHKRRETISVASIRPPAVAPRINRSAALRTQKEAAAPPSAFNLRTPATISRSSSRTSINTVTAPTTARRPASSQGVTRPPISRTTTSSSSVSKPSARPSSALALKPSNGATKPEPQTPAAKPKPRPSSIQAPPTIAPRTNKSALLRAAKMAAAGQNGNGVAPKTPGPVKKAVIATRAVKATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEP6</accession>
    <name>A0A2R6QEP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v3676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000361">
        <property type="protein sequence ID" value="PSS06546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEP6"/>
    <dbReference type="STRING" id="98765.A0A2R6QEP6"/>
    <dbReference type="OrthoDB" id="2499463at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="60"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="260"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS06546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="734" mass="82851" checksum="E8E7E28F1CC1A1D6" modified="2018-06-20" version="1">MATNIHGNSGPSFATLLANTRDAAEKTGKYSSAETRALLTQQIKDRCDGKTPYDWQLDVTEAVLLGLDSIVVAGTGAGKTMPFVMPLLADTTGKKKIIIVSPLDALERDQAQRFKAMGLTATAVNGRVWNEDLHKDITAHKYRVLLTSPEMLLEHPVFSALMRSPEFMKDVALVVIDEAHCISQWGSDFRPKYGELEKLRSYIALDVPILATSATMTPAVLDDVRVKLRYRVDNMFLINLGNDRRNISLLIGRMQSAAKDLEALDFVLDEAFDGKPLIRTIIYVNSRDLAADAWEHLADQLPSHLQEQIAYIHAMRSPRAKEYVMTRFRAGEINILCATEVAGMGLDIPDVDRVIQYMLPKTLSEWVQHYGRAGRGGQPAQAILLVEPSAFQTKKKKVEEIMDPDKQQDEENIISTLDNGQENQHGPGLSSSSNRTSHNEPEYKKNVEDGLRQWYEATTCRRVIQNEYFKNPPSDHDLIVACCDLCIARYASKGGPHVSTQSEHNLEALLTRIAMRKSIETPDHDKQLDGKKRKSGEGTRRGTRLQSCRDALLGWRRWRWCQTYRDCFWGKESLLPDKVLQMFAKAAHIHTLDDIKREIPDWEWADDHGEEILERLETIDNQWHAERDQSAVVKKTKRRETSKQNKATREEVRREAKHQEVLKKKALQSRIASSSCLPLLSAVAQSQPLPSSASAHLQPTAWQWVTSAPVIMSAAAVSSQHERPLQWMPLFKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEY4</accession>
    <name>A0A2R6QEY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v3541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000356">
        <property type="protein sequence ID" value="PSS06855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEY4"/>
    <dbReference type="STRING" id="98765.A0A2R6QEY4"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000224">
        <property type="entry name" value="serine/threonine-protein kinase mph1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="516"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS06855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="875" mass="96073" checksum="2176FB47301C5784" modified="2018-06-20" version="1">MISFPPSSTHRPSLSSPPATPPLDHQTVDRPQLSPAYSDDLDVLPPFEWERDARGDWVRISNGSSNPSPAPSTPDLHSPILSHSPLPTKRSSPLSRAESAPDVISHPTPVSRQFSRTVSGPLATTISSTPAASSARLLQSTGLSGTGRKISGAPRRVKLDEVRETNDRARQEAESWKQQRELRNAVTQEKENADYLHSAASSSATPSSRPLTDVMPVPQRSLSAHGRQVLPVPSRTARMMKKVETIAEAPDGEEEAAARMSAAAVTSSTGARPRRSYSLSEADGEDSDHPHYQQYLKSEFARGARRVTLEEKLKQEREIAREEGYNLRAAEEAEERLAYELINAHAQPSETGLSGSPTHVPSSNPRPPYAHQRMDSDTVKTFGTSSPTAVEHPRGFSPTGRSYSSGTNAAALSVNAMGSMARHRRSPTAPEAPVASTALALQQNAKVWDDEDGNIGHYQADRHVPAPGKMTDSASMPPPPVPVARVHSVPPQPSHQPPAFSSSDRARNMIVNKKQYARLDMIGKGGSSKVYRVMSGNNEIFAIKRVALDKTDAETMSGYMNEISLLKRLDGNRRIIRLIDSEVKAGPNGSKGYLMLVMECGEIDLARLLQEQQKEPLDLVWISYYWKQILQAVHVIHEEKIVHSDLKPANFVLVKGQLKLIDFGIANAIANDTTNIHRDHQIGTVNYMSPEAIELPDGMRRLKVGRQSDVWSLGCILYQMVYGRPPFHDLSVVQKMRAIPSESYAINFPEFATPPITGSPPKDLESLKVRVPVEVIEGMKGCLIRNPKERATIPELLAQNWLTLREPAMPPLPPSPPPPAPPQLKDDEAIISPHFMAQLLQHGMGIGNRGEVWSGADLEREAKRLVAELQSVYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIP0</accession>
    <name>A0A2R6QIP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v3435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02000340">
        <property type="protein sequence ID" value="PSS08868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIP0"/>
    <dbReference type="STRING" id="98765.A0A2R6QIP0"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS08868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="224" mass="24838" checksum="28DA68BE85ACCD07" modified="2018-06-20" version="1">MAALSVAGYGIVDTMYFREDDRLVLTPYNFLLYNLSSENLAQHGLHPRWLHLVVNLPMLTWIIFNIVLSLLFGVLHQGGVVPSLLRLHGLINGESSSNGSAIVYWRTYMPPRHLLGIPEHDVVSGRVRVTDLAGAPPDQVENTLVSLISHRKNTTLYIVTPPFAMQALQSPLSACFAVEKHLFPHLDMDHIPESLEVGWPEGLTLGIYVADSDCIEGHAFSIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIR6</accession>
    <name>A0A2R6QIR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000340">
        <property type="protein sequence ID" value="PSS08871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIR6"/>
    <dbReference type="STRING" id="98765.A0A2R6QIR6"/>
    <dbReference type="OrthoDB" id="2593747at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS08871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="186" mass="20954" checksum="85AF4BF3BDC920FB" modified="2018-06-20" version="1">MLAFAKEAGMGKTDECAIALPNVAIAAFELLLRFLYFGVREESFSASSEDWVALLSIATSFQFQEVRERALAELESLHLDAVQRIVLAREYDIARWLAPAYIDVCVRERSVVPDEAQRLGATVTAHIAEVREKVLLGMLIEAQKPPFTDSFGKWKLKTPTRDLHHVEQLVDEVLWPDSFPVPRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM73</accession>
    <name>A0A2R6QM73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM73"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS11025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="485" mass="55937" checksum="9D7E00F5B1D5313D" modified="2018-06-20" version="1">MPILDENIHTPASVLGRCPFLFTVICAVSSRFYEEKPDMYTMAVHFAKTAAANSFLDGWKTVEMCQAYALMAAYMPAARRWDEDRTWFYSGIAFRLAIDLDLNRPPSVKPTDERSEREILNRLRTYVVCYIMDRCFCINLGKAFMVPEDELIRNVASQFYGWKYQHKADGYLVSLVELFRIMTRFAELANPAIEARSASNDWSSLKEHQETDLLTTHKVFAEELNAWKNTAMQRCAPEHASKDPDDCLRMALMHSVYQYCRLVTFSAGLQQVMKRGKLKEDEVFFTGCLHAGSAVVNCVIDRILPTGFIRYSPEHVFALSAFGTAILMKCLRPEFASKLDGRQEARIFDLIKRLLKSMDPEQLTTDDQVTPRRCYAKFLQQLLTSRMVEREQHRMASQPTMAQDQYFGEDHQEYIPDQVEQMHISPVLEQKTLQSMDPQLVNVPFTNPWDPTSNQTPNAMNALLGFSESEYMPTFMAFPDQTWFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QMA7</accession>
    <name>A0A2R6QMA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v3339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QMA7"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS11043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="8908" checksum="D823AC5858C8A49B" modified="2018-06-20" version="1">MSVIMPVGALLAAVLVLIPLHSHWKARNVPTISMIIWLCLVNITRAVNAIVWRDNLDLKLLVWCDIGKQSSVYPMTPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXJ4</accession>
    <name>A0A2R6QXJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000299">
        <property type="protein sequence ID" value="PSS17120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXJ4"/>
    <dbReference type="STRING" id="98765.A0A2R6QXJ4"/>
    <dbReference type="OrthoDB" id="2803047at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="165"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS17120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="744" mass="84314" checksum="BC83352143E5CE83" modified="2018-06-20" version="1">MSRPITPPPTDKRFHDPSIKNTPTISRRTHGTIFHQSLLADRRLYNLLDNNGKVILVSPEYFFNAVIPLVSTSRVDTVIEGLQAAGLIVDGRWCAFPQDPSKSRKNEIETFNPLIEITDAIATLGAGKDRASLVTYESNPYAIPYSSLRQNSTHPDGYFILKERNGNRWIDISVTAEFKKANGYEQVTDNINKMVWSLLQASRDDARKRCTFGFTIEDTDMRCWYWNRGTLLVTEPFNFITEELGWDTTMKRLKTDPNVLDITVRSATKRKSVYRTIKMLSDYRTDSLVGRGTRVWEAVRLEKGQPVGPHCALKDVWVEVDRRREGDILRDILDTDTPTKDLKKFFFTVNRDGDVLVQDGRPDDTFSVMMRGQLLPDDVLAFDLTPPAPAPILSESSKMATGSPAAWEEVKVVRMEPSLPCAKRHYRIVFKEVCKPIWEETSLHTIFQKLGQAVYALNMMHTSGWVHRDVSTSNILIDATGRARLADVEHARHTHDTSSMHPVRTGNADFMAVEVAQNQYLFRSKENIVPQRIESNPKAAPCLSTDFDDPSSSQKSTLRVDTPPPPVYIIMPKFPEKPTATTFKFWYNSLHDMESIIWIVLYFVVKRSLVIHDNNFNATKQNNLAALLVFSNSTARQEFLKDATLRLLSDLHPSVHAVTTALSAWVAKLVSEYEKVEKDISSISHLVANGLCTLIHQDIRTICQMNQLCDVQIVPVRRVVEKRDGDDSKENCDIQARTAAIKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHY1</accession>
    <name>A0A2R6RHY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diaminopimelate epimerase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhzF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHY1"/>
    <dbReference type="STRING" id="98765.A0A2R6RHY1"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF17">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS29608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31556" checksum="89BF6ADEB3117C50" modified="2018-06-20" version="1">MALPFYIVNAFTTNPYGGNPAGVVLLKEPLETEILQQIAKNFNQPMVSFIWPVAEDLSHDPQSAIFNIRWFNASLEVPLCGHASLATAGALFALNLLPPTVNTVRFQTTTGRVVSASRTGDWVELSLAAATTRVPSQDEVDRLTKITRKGLDKDVTVNYVGIGGEGFESYVMVEIDQADDLAGCKPDPGAFLETGYTVNIVTSSDSDSDVNFISRMFAPAASATIPEDPVCGSAHCLLTPYWAHKLGLNDAPMVAKQVSERGGDLRVRWRGPEKLISLGGQSRITMKGDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIQ8</accession>
    <name>A0A2R6RIQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000245">
        <property type="protein sequence ID" value="PSS29888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIQ8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9669" checksum="7CF4CB6EBD8E9E63" modified="2018-06-20" version="1">MIAARSGKSTRANEMESEIGSGRTLQGCNDNLPMRPLAIKITTEVDSDVTVISHHSNSKVPPLEEMKGQDTVDVYQTRRSSITCGADSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPL7</accession>
    <name>A0A2R6RPL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000211">
        <property type="protein sequence ID" value="PSS31966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPL7"/>
    <dbReference type="STRING" id="98765.A0A2R6RPL7"/>
    <dbReference type="OrthoDB" id="2803741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="103"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="24189" checksum="2A4B896A4E239A0B" modified="2018-06-20" version="1">MPPVDLKLVKDVVESLRSGQNPVIVGERWADFQVDPNKFEADREDVVFRPLIDIMKAVANAATVALGGNKLRCTYESNPNAVPASESRDNLTRPDGWIIRMGSKSSGKESHWMDMAATGEFKKEDLEPKVTDNNNEMLWSLQHCMVDDARRRFAFGFTIENTSMRLWWCNRELVVVSNPFNFVLDHLNFVRFILGMLFSSETELGWDPTMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPP4</accession>
    <name>A0A2R6RPP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000212">
        <property type="protein sequence ID" value="PSS31959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPP4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="160" mass="17354" checksum="415260956BD65D21" modified="2018-06-20" version="1">MNSFGVAAGKAMMIARHKLCRDPSAADVFKSNDSCSQNVQNDVKSLKTGDDFGSQGGHQTVAYQQSGVHPTAKRLAFSAGSHKGKDTRMGLYNICPVVGTKVIFDPMLTAAISCTAQPQSTEATLARFPIVLESGNKHTKQMGTSKRRRRTCDPNWIIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ00</accession>
    <name>A0A2R6RQ00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000198">
        <property type="protein sequence ID" value="PSS32096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RQ00"/>
    <dbReference type="OrthoDB" id="10007484at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="211"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="528"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1475"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS32096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1978" mass="222248" checksum="91F3468B2AAAF5BD" modified="2018-06-20" version="1">MSELNAELLSILTVAELLGLIAGAITVPRSHFTPKAKLIEWIIVNSTGDLSNALTAACEAKLQQGAALREAKKRKRAATLHSQRKARHQRWLEEADMHNIEDYLKLPSEDELLGCYREFIEATSNAATKLVVCAVCAREVSHRDDIVSEIPLKEIPHRDRLTPSTPHHMHDIFEGMLLEPTGIISEGLESPSAQVCKACLDHLERIEHGPPPLSLANDLWIGPIPWELQVLTVPEQLLVALLYPRVYVFKLFPKDKDFRPKDDTLQHGMRGNVSTYEQDIDGVAAMVEGHLMPRPVEILSRVLTITYIGRGQLLKHSLHSTFRVRREVVKRALLWLKTNNPKYYGDIQIDEERLGSLPDDDVPSEIFDVARHTPDIGIVDQEAPGYVPEDPPSSTTDDMLGHEATGLEEQEENGASESNDTDNDQPDVIPMQVSGAIDTDLTTLTSKELMLWGLANLWKEGHEGPYSIRHGTQPVRDLPPRRPADEDAQFTRPDSSHNLFEKAFPCLFPYGCGGLEAQRPIAVDFPTHIRWCLQYHDRRFRKHQTFPFLCFGIVQKRHALSNAQLQMKRKNFEHDARIMSSLTAAKLRQAAAEEEQGLAPSDPAVRLLLRHVHATAGRVVGTDQSRYRLRSQIRSTSIEHGPPTIWATWNLSDHDDPLAQAFLGENIDLDNFIATLGPDRNTRASNVAADPYGAAKFFHFAITAILETLVQMKVSKYQVRSKPGIFGEASAYFGTVESQGRGTLHLHILIWLKNTPTGDELDDLFKNEQFRLKMAAYIKANVRAYVPGLESPESVKAMPRQPGVAFSRPPKPGADNYEADMQARELQLARSLQVHTCKIRRCLQPNKNGKLVCKRKAPWKCAAHDFVTDAGQWGPKRLYAYVNGYNPAILIHAGCNNDCKILTNGSETKNITYYITSYAAKKQGRNYNLSAILADGYVYHLKNPRDEYIDRLRENQRLLLFRLVHTINREQELSSSMVIAYLMKWGDVYRSHLYTAVYWSSFVAALLKQCAGIQVSSPQEPEPPLGEAADNVAGPSHVVVEQEGATETSLADQDIPDDRPNNPISEEHLTPHLPSESQGEANDEDGDDMITLDITPEGGHVYAKSQVTDYQLRGDELEECNVHDFFRDTYETALLNPRRFSARIVPEASDSETEDDNTGLGLQAQRRPGRRPNQRTHYLPQHPNSAHKIRVVRSALHRNMVNYVGRFFPSSKDANTYPLYCASMLALLKPWRDLAVDLKLPQQSWPDAFVQFKAQADTRILRILAGIEYYHDCRMAARDHVDEELPLDDRQDADAMRGIDDMELGEGVPETHTTVSEAAISEVLMLGTSPQELNHARHAIEIARSVKIFPDENDNWSVTDTEVKNAEGGDLVRLSEWQKCMHADVLRQNTAEDVATNVVAAVTDTANVTPQVMDGANTHAGPNIVATTPVLSSADGVLTAANVNMLKDDQFRAFDIMRWHLDQTLAGNQPPVLRMIIYGEGGTGKSKVIQTVTEEFARRGVQYMLVKSAYTGVAASLIDGKTTHTIAALSVKNGAVMSDDAKAKLQVFWKHRSYLILDEVSMLGKTHLQHMERNISIGMHGADGFKPDCTFGGLNVVLCGDLHQFPPVAKGREEFLFHPIRTYDDDDCKLGRRIYEQFQTVVVLQEQMRVTDPVWQDLLVHLRAGNVQREHVQILKRLVLSRPSAMIDFNEEPWKRAALVTPRHAVRLLWNEHASRKWCQATGTQLFVCKAEDTIHRGKKIRVNLSLAERYQVARRVQTDNRRRRADLPRSIELAKGMKVLVTSNLETDLDLTNGARGEIIDIILHPDEPAIGQTPVVELRYLPQYVLVKMAKTRASQLAGLDACVIPVEPATSTMQIKLQTHAKKAVQRTVHRRQFPITSAYAFTDYRAQGQTLPYVVVDIATPPSGGLNLFNLYVALSRSTGRDSIRLLRDFDPGMFMQSHEPELALEDERLEDLDRITKQWWIAMGGEQRLLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ06</accession>
    <name>A0A2R6RQ06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000199">
        <property type="protein sequence ID" value="PSS32079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ06"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015335152" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8000" checksum="0512B02957BF8683" modified="2018-06-20" version="1">MQATVNLPRFLSILLVMGPTRSYQLVAGIGSPVCKNQARHMLAGTSRLVHHVMRIGSKSAPATRGVDEVCNIGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ32</accession>
    <name>A0A2R6RQ32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2140</name>
        <name evidence="1" type="ORF">PHLCEN_2v4971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000198">
        <property type="protein sequence ID" value="PSS32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ32"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="282" mass="31452" checksum="D8ADE6F2FA8CD8AA" modified="2018-06-20" version="1">MPQSNPKSGHRQNFSKVCYRSLREKEAEAEYKASSRLAVKAISRLGLGTASREKMQMEIQSEDPYLSSYNLSLMQDPRVQQYHRDKEQGSLHAGIGLSRYTDREGLPLIQLRQRVYYPANRPQSSDFIPADPVTFVVNGRKGISVVDAASHKTQGLEDADKEVVLSTTSTKVDLRLLTSLIVSGQLQLDLEGSRFSDHASVARLPARRETNPPKGHQLRNVASDFSEAIEGFFQVEGGFIMLPVGRHGLMPVYAEQLLLLEVRHVSKGSYQAVLAIHDTAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVE2</accession>
    <name>A0A2R6RVE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000163">
        <property type="protein sequence ID" value="PSS34002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVE2"/>
    <dbReference type="OrthoDB" id="124582at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22680" checksum="E0D5F8D00E1E2B3B" modified="2018-06-20" version="1">MPWYTDVMHEIKPITSGYRLALSYNLIHSTKSLRPALSGKLGMMGELRKVLVAWKEDGGELSPEKILFLLDHKYSQANLRASALKGADGQRVALLDALAKDYGFCLGLASVVCHLSGCPDDDGGDRQRRGGYGWGSNDEGGSDYDERLSFAEVSDRDMAIENFVDLEGEPISETLLDVNEEEEMIPANLSMVLMTTRNTKGIWEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVL9</accession>
    <name>A0A2R6RVL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000161">
        <property type="protein sequence ID" value="PSS34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVL9"/>
    <dbReference type="STRING" id="98765.A0A2R6RVL9"/>
    <dbReference type="OrthoDB" id="10693686at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="15712" checksum="F7FB407217ADED58" modified="2018-06-20" version="1">MWLVLAKKDESVLPTKWIKFLDVLLNINKIVNPEKSRDTAFSKNKDKQVATATAGKKKFCHICKKTSHNTDDCYQLAKNFDKKSKPKYQSMGHDNWAGGNGSQAFRNFKAKKMHVIEVEITDDEGETLQPSTSVSSVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW21</accession>
    <name>A0A2R6RW21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000140">
        <property type="protein sequence ID" value="PSS34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW21"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="31936" checksum="2B00163290B88990" modified="2018-06-20" version="1">MTTTTTQSSSSPSSPSHPPEPLDNQNNPLTSDNSRVEQGESAIAATANDPSLVSEADQESKNNNNAKSGNVGKSDPTKSTSPDEGGEASGSTAATPATANESGTGTPAAGDWQAIWSPLHNTYYFYNAATQETTWTNPLEQSSTSSSTSTSTPAAPADEAQPSTSTSASASTPASLASMYALQQAAADQGIDPSLAFLDPSLAAGPSNPAAFTYTAKFNARTGTFTRPDGRDPTHLSEYERAKRMSEAYFDVGAWEQDVEARNAEEEAEGKKRKRPTKKDLERFKEQKRLKKIAKTAWLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZB0</accession>
    <name>A0A2R6RZB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v1684</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000137">
        <property type="protein sequence ID" value="PSS35347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZB0"/>
    <dbReference type="STRING" id="98765.A0A2R6RZB0"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS35347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="600" mass="64994" checksum="D28C99E25B11F09D" modified="2018-06-20" version="1">MSAPIALLSVYDKANLLDLAKGLQSAGVRLLGSGGTAKKIREAGIPIEDVSDITKAPEMLGGRVKTLHPAVHGGILARSTPSDEQDLKAQSISPISIVVCNLYPFTETISKPNCTVADAVEEVDIGGVTLLRAAAKNHERVSVISDPADYAEFLEAWTKGNGDVGQNIRSKLALKAFEMTAKYDDAISGYFRGQYASADSPEDKFTGTVQRIPLRYGANPHQKPAQAYVTEGELPFKALYGSPGYINLLDALNSYALVKELFEALGLPAAASFKHVSPAGAAVGVELNEIEKKVYGVDDLKEPLTPLACAYARARGADRMSSFGDFIALSAPCDLATARIISREVSDGIIAPGYSPEALEVLGKKKGGKYCVLQIDPKYTPAEIETKQVYGIYLQQKRNNAKIDAKLFENIVTKNKELPSQALTDLIVATLALKYTQSNSVSYAYRGAIVGIGAGQQSRIHCTRLAGTKADLWWLRHHPRVLALPFKKGVKRAEKANGIDLFVGGEVLEGGERTQWESLFESVPEPLTQEERTEHTRQLTGVACSSDAFFPFPDNVHRAFRSGVKYLAAPSGSVMDEECVKAADEHDMVFAHTSLRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZD0</accession>
    <name>A0A2R6RZD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000135">
        <property type="protein sequence ID" value="PSS35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RZD0"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="220"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="535"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1228"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1783"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1883"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="78"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="482"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="616"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="757"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="873"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1265"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1360"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1474"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1790"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1805"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1838"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1858"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1915"/>
            <end position="1924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1940" mass="215551" checksum="18F4B5D82325461F" modified="2018-06-20" version="1">MTKTRRQSKVAAAAATGTSTRGPSPVPAQEQTTFSVVIPEDVDFDLLSNLLPEMQLDSPSPEAIVSLYRLIAGQASEIDATTRELEGTKAEVERKDIELDQALQDRESASRELETTLENVQNELRQVKQEKEEIVASRSALQAQLSAISNSQSMSSSEVETLKHRVEDTEREKRDLVGLVSRLKEDAVQREGEVQSLRAVVRQARQEQQAVESQLRELRSTETSTKFKLDTLSQQLKLSKDEAERASAELMTKSEEFAKYRRTKHAEFAQLQSAHDSLIQTHAAAESSLKALQSAHTTQTHQLTQALGRVQTLTGRLAEQEATYSSEAAGLKRLVEMMQDREAQAKAIVEDVEKRWADVGDLAERREVVLREEIETQRQRAEEAEKRVQDLKGLLDRLDRGEFPHPGAAAGSAPSTPARGPTTPFRNDTPDFLTHGMMGLSPTVAMASRAQRGGKTFTEIYSEYIKLQEDYARKSIENEEMARSLTEVLAEIEQRAPMLNQQREEYERMQSEATLLASQLAQSLNERDAHAMLAEENGQKLAKSEKESELLKKQLDDLGRQVQVLLKELGRRQDPSIPSDEELEADEATAPAENIEAVITNNLVLFRSIPALQEQNQKLLKVVRELGAKMEAEEQEYRAELQAEQQVALDEAFAAVSKLQEQLENQKKHGETTIQAYMKERDALKSMLARERASARSVNGINGHGEGLNNGTDTEKELAEIQAQFEAYKTEMGVDSGTLREELLNVRHEAAQVGAQLAKANAKIEYLNDRHRMLQEQNNMQNRELDNLQRRNQELYDQYTRIDIECNRVSEEFQSASGLVEQLRNETANLRAEKKIWESVQSRLVDENKTLAIERSHLSDLMSNVQKMHNDLERSGENDRRRLENQIQMLENQTQDLRTQLTQERDSVRHLSLQKDLDLKELRTRIDKTSEEYAKTREALVSAQTSKTHLEAQVEQLNRRLQGNEEKLSVYEHRSSGVAGVTPHTDQDLSREQQLEAEVAELRSTLKVAEVDLATARNHVQQFQDISQANEAALASLNATHDEFKASTEAQIAKHESEYRALQDRLQSVQEEHARLSSNNVELQRVLETERAAWSQDRRTLEDTIVDMTTSEKSTESDRASRESEVRQQEERAKVAEERYGREVLAHAEAIKTVENLKQQLSGARANARDQSAAAETAQAKLGASEASWKQQKDALDKEIADLNARCKDLSAQNNLLHQHLESVSSQAARIRQAADSSATPAAGDVDSTEDVDTKLSELRSVVTYLRKEKEIVDLQLELSKQENARLRTQMEHLNQSLEEARKTLSEERERAVEAAASDAQHAELVERINQLTILRESNATLRADCETQAKRARILDAKLQQLSSELEPTKEQLRMAQAELETRNEQVRRLEEDSHKWQERNAQLLSKYDRIDPAEVQALKEQIESLYAAKAELEAATASNASDTVEKVAYLEDQIRKLKDTGRRNNDVAKTRFSRHAAEKEELEATISQLRQELQTVTAEKDALKVQTESPATVTREQELLQQIQTLDQDKAELEKRLLEVQSTTGSENEQILALRQERDALLVEKATWTATASSPEGVQVQWETEKADLIKNRDEATAKAKTTMERAQHAAKAAHDFRAANLKLNAQVQELLAAKASDTENAAAQQKAAIEAAIERVKAEMQAAGNSSTETDSRHAEELRALEERLAKKYQEELKSAVDAAKANAAKGTAGPDQKAAIDAAIAAREQEWKSAHEAEIAAAVESGRREAEAKNKIKDAQLVRTQAKLKVLEGQLEQLKNNGILPDVVSNPPSATTQPSTKLPGAPAALQAKPSAAPTTVKPSIATAKLGAPPPKAPAPAGGPSALPQKPGVGGAGRGHPAPRGGAPARVAAAAGLVVRRAAEGAEAKSNDTGVSIMGAAGKRAREDGEASGDDALAKRLKPEGAGKPVPIQRNRIPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZY3</accession>
    <name>A0A2R6RZY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1461</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000114">
        <property type="protein sequence ID" value="PSS35584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZY3"/>
    <dbReference type="STRING" id="98765.A0A2R6RZY3"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS35584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="229" mass="25069" checksum="0FD880B2E5634BB1" modified="2018-06-20" version="1">MNSEDTLHDENGFHVLLQSFAMIIVSEIGDKTFLIAAILAMRHPRMVVFAGAFGSLVAMSMLSAALGHLLPTLIPKRWTQALAAVLFLVFGFKMLQEGREMKGGNEKIREEMKEAEEEIEGDDAVRESAGNATGAIPLEELEEGGRTMPTGGVRHARTRSQSTNQARTLVDKSRYYCSDILGPHFTQAFILTFLGEWGDRSQIATIALGAAHVSPGTFCFNRKLLLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3B7</accession>
    <name>A0A2R6S3B7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3B7"/>
    <dbReference type="STRING" id="98765.A0A2R6S3B7"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS36745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="735" mass="81239" checksum="231B92CB25A9E32F" modified="2018-06-20" version="1">MEDQKPLAELSPYSLRTAYPAPRVHIPQSSPPPPPHAPNDALNQVHHHPDNSSCTYSSPRQQHLSMPDLPPSPQRKTVSSASANARNVQPQKKPGAPKPKGAVRAKSGCYTCRIRRKENNSVTELREKIKTFLASQGMIKGHSGSGPRSNEGEPQVLVLVENLQPNPPGSPPTPTLSATSSDTHRPPQMTSYVRENGGGYHHAPPSMPPEPHFAPPQTRLPSNGSSAYAQYPPQPALESSFSPLYTQNFAYGSDDDPQEPPDQAVNALPVMMNSYDSMIPYDQKDLVAHYMQKVLPIQYLLSDFTSINKFIYDLIRSSESARDAACMLAAIHRDRMGYVSPTSEDGIVSHPANFLYERLFQGLARKNQQYSEGDAMAGLHAVSTILFSGGRGAWDMFLNVASQYVVGILVDPKYYGPEDVLLRCSESTRFIIKTTMWFDVLASVTTQQVPRFHQTYRTLFDRSTRAYIEDPSKLCAPEISMLPVMGCENNIVLAIAEISSLAHWKESQRRRNCLSIPKLVERGTEIENKYLTPGGMSSPSTARVANGHLAGSSSSLAASGAYGLGLDTQQAMGVNGHVRLVNGRNGSTPMAMYTPPTEVELRRQLTNDIFRASARVYLHTVLSGDHPSCPEIIDAVTDTINCLRRVPLDKPQLSRSVLRSVVFGICISGCLTDNRDQRAFLMRLLQTQQSESVGNVAEVLDLMQQVWQRRDSNRGAPVNWRDVMRESQRELLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3S2</accession>
    <name>A0A2R6S3S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000093">
        <property type="protein sequence ID" value="PSS36926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3S2"/>
    <dbReference type="STRING" id="98765.A0A2R6S3S2"/>
    <dbReference type="OrthoDB" id="4584900at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015320714" evidence="2">
        <location>
            <begin position="24"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="267" mass="28242" checksum="C0D3184A5ADC34E3" modified="2018-06-20" version="1">MAILYFIRVCTVAVLLGTSSVLANPVASLVRPSSHVETRRAPSSPGSLPLNPTGSIPHGLESAMSNGQRLARGLSPKKPKFRRAEVDRSRPRPSPTPTSSAGPKPTKGACVSRTGIVHVTSPSNSPDDGRGARPHLDGYLGMRGNVFGEFEYTTERRDALTVTVDDCAGAPFDLVASNGFKAFPFVGGIKGFSSDSPNLAKRSYNYVYIGGVTETGPHATPRNTGNAFSAATDISEVDESAIWSFQKGSNTILEAQWVNADGCEYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4A5</accession>
    <name>A0A2R6S4A5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4A5"/>
    <dbReference type="STRING" id="98765.A0A2R6S4A5"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="140"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="349" mass="38764" checksum="D4DFDD65A32AE8DB" modified="2018-06-20" version="1">MGLSIFHFLYLPTLNTRVRHYDVVAAPQSGWSSDPFSLTARNGYLYGRGVTDNKGPIMAVACAAAELLGKRALDLDIVFLVEGEEEAGSGGFEETVRSNKNAIGPIDAILVRYMPSFFEKNSAECAMKQQFDMDSRRHAFKGPDLHSGVDGGANAEPMTDMIRLLGTLVDGQNQVTLPGFYDCVRPLTEQERQLYKVLSGVTQTPATVLSAKWREPSLTIHDVKVSGPTNATVIPSMVTSRISIRIVPDQDLDTIARTLQDHLVHQFKGMRSQNSIEVSIPRTADWWLGNLDDLWFKALEDAVRDEWGVEPLRIREGGNFTLTSLCLLYPTSRKSLLVMRSTFLWGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4A7</accession>
    <name>A0A2R6S4A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4A7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7052" checksum="100B37E3A3F2E7D6" modified="2018-06-20" version="1">MNGNSWIPHPQQHYSQPYQPLETPVAVDSVHDAHRLLGSYPFASATPSTHGESTSMSIWLDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S563</accession>
    <name>A0A2R6S563_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000045">
        <property type="protein sequence ID" value="PSS37393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S563"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="9995" checksum="39EF9526B9B47D34" modified="2018-06-20" version="1">MDYVVSPHDVAILDVKMQVSYAAVAALTWMTWDTIIHFDIEADSEQWPIIMGEVDIWLHPLSSYHTRRSDNDSVERLYYIRLIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5L3</accession>
    <name>A0A2R6S5L3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5L3"/>
    <dbReference type="STRING" id="98765.A0A2R6S5L3"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="45"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="369" mass="39972" checksum="99D19FD3578A0C73" modified="2018-06-20" version="1">MAAAIAASLPAPQSAPTPAGPTYEAIPASMSKVIDIEADIPLACVQLDGMVVSKIIKHAREAHGTSAHGVLLGLDLDGTLEISNSFPLPHHINDDDDKSVKGVARYQASMLRSLKEVQADDSVVGFYQAMALGSFYNQTLVETQAIQQEKLRHGGVVIVHDISRTARGNAAFRAFRLTKAFLDAYKRNNFSTESLINHRMTFSSILEEIPIRIRTSPLLGAFLDTLSAPSVSAEPSFTKPSSALPPSFSVLNLGTNNVSKNLEQIIEAMDAYKTEEGNLAYMQRQIAREKGKADAYVAKRKDDNAARIAQGLAPLPEEDVSRLFKIPVEPSRLDSMLLLGRIDAYSKTLEETSSTALVKMYASRGSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6E0</accession>
    <name>A0A2R6S6E0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6E0"/>
    <dbReference type="STRING" id="98765.A0A2R6S6E0"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="603"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="793" mass="87624" checksum="480EA66CD17454E2" modified="2018-06-20" version="1">MLTGTSSSHHSWDPVTETFILSTIGKGNTGRLVISGMDHVVSGSLVERFLTIGTLLRRMEHLVSELRQSSIKAVPSFHAFTHSLSSVLKSISSSVSKTLQTSYLENINPDIHTLTSVWVACAPVEADLRSLASLCHRQPELSPSQYSPLPRTAPELLSSIYRRLETALDNHSLRTTAAIFAFMLTAASADYFDQLSKSLGYGKRDLSSRFSLFPLDPHEGPDIGILEDDALEGNQENSYIASSDGRSFPSFFSPSLSQALLRARQSLKLLHAAQPGHPLLVSSRSRRKIHWFWTEELVESAWLDSQVFTSEALHERQPSEPATYGVSASSLASSSQYKDEFQAFRFFDLEPGSHLRALAEVDKLTAISKFDAFIQTFPASLPSLTPTLSDLTDLVLAPLADHINSLSSALVDTLLTLNPYLNFHNHLVLLRSYLLVTSQAFRSRLEHALFSDAAEGTSTQTSARTMALRRPRSSASQEHTTSTPPDSWVIGLAPSLTAGDTWPPGGADLSYSLRTVIIDSLDIDYHGRQLSDQPRQLSGEDEEESRKLAEEAEWRLGFAIRDLPVGSGRAKWLNPRMDNVNRALFRMTLSTSEPLFPTLASSQKLFLHFRFVASSFVTALSSYVFDNAIRGIFDHFLSQLDRRGRDRDASEGAKEFADVFELANYHSKIMDDILGACLLRSSQKAVGDLLRGVLEIILEFGILMGDRRRGAFEEYQAAGPLGDLFSRFKSKMKTLMKVLKTLVDKGASSSRVVLEDARFGSGPLPPAVEGTANLLGLLVRLDVSRWWTHGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6T4</accession>
    <name>A0A2R6S6T4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6T4"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="896" mass="98677" checksum="B018D2A9F20B3C37" modified="2018-06-20" version="1">MTAFLIESYKNLSEDPTTTTNMLLQQISSQTNSYSIHDGFLNSTARSTTSPQPFEPSLAALRVNILWFASLIFSLATASFSMLVKQWLREYMAGEFTSPQARLRVRQFRHPALSHWKVFEIAAILPILLQLSLGLFFLGLCFFTWSVHPSIGRTTTPLVAGWAFLFFFANVAPIFSSRCPYKTTLLKDTMKSVRRLLCRIVWLRTLYIGPQHPRSKSLSKRINNPTRFQSTNLADFLFTHQDGSRDPPGYIQLGNVSGPPFGSNRFNTPDIAPITYDNPLQRPVYQSGPSYELQDAGNSEESSLLPDSLSRFPNPVIVNPPQPDVNRFVVAVTPMIEVMTPQVDQSTAGSGAIPCPVDVPTLDHTHAQDFQFIEPLEDEDVALDVSGDIRTFIAVDEIMMLDDNFLGTTMRESLQQSTETDMIKFVVKAAGNRLHKPEGLDLSSVPDMRSLSKPGWTSITDITADAVLRLLAELDRGSHGSDWAGLKDIKDALTILFARSDNPLTSNGNQALALCVSGDPGKIIRALLLAVHGLSHAAMLERLHHALVGLPIQDAMPALTSLFGELIVKPETSQPQHSELAGFVQVDSLPAGTLKATLDILVDCAARSLTARKGSPMWLEYALRAILSAPILPNGTTDVSKLLSRFLCEPGSVIFILTPVISSDPLRRARSLTSAEGNIGSAFLDSDLAGRGAILQNFAWLMDRLARDLTDPTTRHLISNTPDPVRMCHLATSMMKMTTKPVVVTLDLKNEWEGLFTAICKATKNYLNEFHSQQETEQREALVKECVEIFEAQVSSAPSDTHIGVAPGPGFSSQFLRNVINTLKNFDTPTRNSNLQGPPRPQRPQWGFNSAGPPMPPRFGGMPRGEPGSERGEFHQTTEDVMAMQSMQGGTSNGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Y0</accession>
    <name>A0A2R6S6Y0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000011">
        <property type="protein sequence ID" value="PSS38012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Y0"/>
    <dbReference type="STRING" id="98765.A0A2R6S6Y0"/>
    <dbReference type="OrthoDB" id="3067719at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="26703" checksum="E37663F7184D0FA9" modified="2018-06-20" version="1">MEESAYGSPQSPSPVRTQLQRSARSASNASRSSVAQTPHHTKAGSRNSFDNDRSPHEAVLRSRLEGVLRGAQKHERRMSANGDISGGSNSLAGSRNRSGEGDSFFTIGESQSADLAVAGKRERTNTSATAPVNMYSYRSPPSSPRALRSPKSPGSLTHTHMQSKPLPNGINLLTPPPTPPFNAVNAAAQCRAMDGYVSFANIEGLGVPQGEEDEQRSEEAKEHGRWLKWLSLGAPKTGRERSEGDVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S736</accession>
    <name>A0A2R6S736_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v66</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S736"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="480" mass="56082" checksum="886FE567F538636A" modified="2018-06-20" version="1">MVPSSLKRVTPLRRITGANIPEDLFETILDFLDEEIELAMTRFDYGEKEKKNKKRELGRCSLTCRYWARRCQPRIFEHIYLRSKRDLEQLLSLLESPSSHISGYIKRLYLTQKSSHFKSWVYLVSLQLVPKFSLIPTINLHFDGPWEETHTKQFGHLRSIHYMLPSARPEFSSHISHLTLYRLRFRCFEDLAHLVGELRALRRLKCTFVRWSSPMPENYVIPVCPPSLDIVAIYGCTDNAIGVLFLMGRRRRMLRDEAILPFCLDRHQPLRAAPFIYNSVRALCGITIFRYAIEKVGGVYHIDCRWFFDTYLTFLFTPTTNSKRSEVHLETIVINLSYSRPMNAAMKWDWKKSDILASRLPDLQKVVFGFESRKDMSRFVNEVVDTQMENLRGAGKLSYAVFDRHKTERWMRASPGSDKLESSLSESEDHEVVNTETENLRSGDGELEYAMFNTSDDSDSDYTEDSDSDNIGDCYKYERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7B9</accession>
    <name>A0A2R6S7B9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-alpha-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v59</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7B9"/>
    <dbReference type="STRING" id="98765.A0A2R6S7B9"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="305"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS38079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39399" checksum="5D8A11E881888AF1" modified="2018-06-20" version="1">MESPTWTPPPPPPIPLSEKARGKLPAGAPVPTASPANGGGKKAATRSIRFSTQPPNDAPLTDVHRRARLRLLPLLSIEGEMTRQLFPELAAGLNPLPDVSLGTSAPPSLPGVKEVCVRAGNGWKTVLASLQAQGEKGKGKGNQNGPIDELTTSLSGCKDDMIALWEDQAVRAVLRRRSVRLQDMPGFFLNDIARVASLQYEPSDDDIVRARLRTLGVEEHRFTMETGAAGSEWYIYDVGGSRSNRPHWIPYFDDVQAIIFLAPLAFNLMLEEDSRVNRLEDSISLWREICGNKLLEGATLILFFNKMDILQATLASGIRVQKYVPSYAEQPNDTSVTSSVVIMYVHLPFYTFGDHPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDL4</accession>
    <name>A0A2R6NDL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDL4"/>
    <dbReference type="STRING" id="98765.A0A2R6NDL4"/>
    <dbReference type="OrthoDB" id="1718410at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="16966" checksum="313363CEAA7BEE56" modified="2018-06-20" version="1">MSQPKSDYAPPDTSGQDLEPPSLEDNWIAIEPPSSPSLRGSNGTEGVPPSRLRPPSFESAQFDVVLRRQRQRPSGGGGVKFTAVPSRFLNLVNTFEFSGWGTMTRMDLNTADLARGDEDIQNARRAITLGQYTASALAGNAVLGSVFYALPAVIAVSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDW3</accession>
    <name>A0A2R6NDW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v13560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDW3"/>
    <dbReference type="STRING" id="98765.A0A2R6NDW3"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR70521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="230" mass="25234" checksum="7ED7727A156C8DF6" modified="2018-06-20" version="1">MAHVLPGEVVPAQHVNLKLGPGLLQASTSDEKDIVISTRAGEVQHTANNRQWWIESNSRRYVPAPQESVVGVIIARSGEGWRVDIGSAHMASLDGLAFEGATKRNKPNLKVGSLLFARVSLAHKDMEPELECYDAQTRKSEGFGELKGGFMTRCSLKMCRLLLDPNHFLLPLLGSRFPLDAATGLNGRLWISTKEPKHIIAAVRCIEAVDPDGDGMDEIELKRFLGTLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEM2</accession>
    <name>A0A2R6NEM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin associated protein KTI12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001315">
        <property type="protein sequence ID" value="PSR70796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEM2"/>
    <dbReference type="STRING" id="98765.A0A2R6NEM2"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34778" checksum="E426F942AF988654" modified="2018-06-20" version="1">MALITVSGYPSSGKTRRAGQLKTAFEARLQDPTYVGPKLKVVVLSDDELNISRDAYKGAFVFGFDLWPETDVLADSRSEKPARGALFTAMQRQMGTDTILIVDALNYIKGFRYQMYCAARELKLRVCTVYAVATTDLCKEWNKSRLDGHAYTEETLDNLLLRYEEPSSMVRWDSPLFTIPWIDAEIPADDIWKAITEGNVKPPNAGTQAVPKAPTDALRALEATTTSTVGAIMAEQAASGGLGGAVTLGISSEIVPSITLPPRNITLSELQRIKRQFVTVHKKAITLGTTEKGAVDWSEKSIAHKFAMYIEENLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEP7</accession>
    <name>A0A2R6NEP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEP7"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13531" checksum="F6D9B05F718A87AF" modified="2018-06-20" version="1">MPTIPVNSDGAVLYYEDSGAPDGPDPYCTIVLIHGLIFNGDPPNFVFGTPLPEEIYVPFRDASIAFSELARRFTIWVSTYHGPVSDITTITAQAIGSRENPTHGTRVDAGYFSVCPFRLFAFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEU1</accession>
    <name>A0A2R6NEU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEU1"/>
    <dbReference type="STRING" id="98765.A0A2R6NEU1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="62296" checksum="6AFB9A1AA85FA2B7" modified="2018-06-20" version="1">MSVPDEQTRIAAEWLTDLASALQSANAEAFAATFLPDGWFRDVLTFTWDNHTLEGRDKIVSYVSKNISPAEISQVKLSDDSYFRPTYVPSSPGPDQGVETGFTFETSIAHGKGYARLVRNEHGEWKALLASMMLVDIKGHEELPGRENFEDIAANRSWGEIEAERKGLIESDPHVIIIGSGQTGLQVAARFKQMNIPTLVLERNTRVGDNWRHRYDSLALHTVREHHQLLYQPHPSTWPIFTPRDKVASMLESYAVNQDLVVWASSAIVGRPVYDSETRTWDVAIDHAGAQVELHPAHIVLATGTSGDPYIPKLEDKGRFTGTSIHATQYKAPQPFSGQDVVVVGAGNTAIDICQDLATCGAKSVTMVQRSSTCVISRDSTVRNLSATWPQGVPVEVGDFKIASFPLGYLRKMAIQHQDKAWAQEKELHDKLKKGGVKVHLGSEGQGPHLLVFERGGGLDKGAADLIASGEIKVKQGFEPKAFTETGILLTDGSVLPADAVIFATGYINIRESNKKLFGEELINQTSDVWGLDHESELKGSYRPTGHPGALMIKAMNLGFMKYDSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF00</accession>
    <name>A0A2R6NF00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF00"/>
    <dbReference type="STRING" id="98765.A0A2R6NF00"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="158"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="489" mass="53561" checksum="8BBB3324D1C5DB98" modified="2018-06-20" version="1">MPPLDDGTVGNNDEDNDPYYNPFATSFQSSFSSAIKPKETRVETRQVFRRRGSETSVRRSRTDHDPWGDENSEGDRGHMRASTMDSVGSSRPKTHPLAAPHLESSSNSSYSSLTDTRPRLKHLLSDLVPRRSPSPEVRKGTTPAGGASDARAKEMIVIIHQVSPKDSLPGVSLRYGISIADLRKANQLWPSDPIHLRTSLYIPLDKAKKAKDLVLSYIESNKDRTTSLTTLMDTGTLDPGTSAPFSIRRIPISQMSFFPSNPSSLYPSPSRPSALTLQGSSYRSYSRNPIPVEVTASSSSGYSVSSLGHSASSSSSLPATSQFATALQLQPNDSTTRPHISSLTSLFNSLPLARISFDSGASTPTHASEDQEHELDDVGRHPQDDRLRGRSHVTDTSGAANVPPNIGTWELDSYPRRTKTVRPQIYFQSSALDQPNRQSVDTSRRRQAVNYTTPERNTLVPDVVRTAQLEPSPTMKLPLRPRGDITPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFG8</accession>
    <name>A0A2R6NFG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFG8"/>
    <dbReference type="STRING" id="98765.A0A2R6NFG8"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="504" mass="55906" checksum="D2D83E01F7A911EB" modified="2018-06-20" version="1">MEAALAEFRAEELGQDGDEDNDFTMEIGVNAVQDTFGSDFESTDEEGAQEDVDAAAERMVMDEEKKTKKAARSQLDKVTAAAHARNKATFNPQITETSTPKTPAVSKPKRRVSMGVVVDAETGEVMESGKRHSLRRNTLMATSISEIRARDEQEKKSAVPKKVKTKTRAPTQAELIARALDMEEGNIKEHRNYLTDEEEKRKKARLVRATVEGPLLRWVTKAEHIKVKVEPPPAPIPPPAPIPPPTLPTVPVSQYAYHFPPYSAPSTSPGMYSTPFPNAPRPVTSFYHSPQTSGFPPSYSSQPYGYNYYTPPPPLQSSSACPSQPPASVAAPPPPPPPPEPIEVIQTVSKCYVVHENSQEEDATKPLWKDTMAAMFGDHVKWEDLKVYTGKGRPICELHLCQMIYIYCSKFLNFPKFIVARPDQKCPITGQTARYRDPRTGVPFANARAFDVLTKVLAHEYVWSDALGCYTAHQDQISQTETVESPLKRTRQQGRAASISEGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFL4</accession>
    <name>A0A2R6NFL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001293">
        <property type="protein sequence ID" value="PSR71175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFL4"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015316726" description="Peptidase S28" evidence="6">
        <location>
            <begin position="22"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39891" checksum="9877E3C5DBE7F6BB" modified="2018-06-20" version="1">MWSSTWKIASVILPLIALTNARLPDGRLHANSPRPPTVPVITADDLPVTDITGAALPPLNTTYIFEQLIDHTNPSLGTFQQRYWTTWQWYETGGPIILFTPGEANAAPYTGYLTNVTINGQIAQQEHGATIVLEHRYYGLSNPYPDLSVKSLKFHTIQQAVDDLEYFSKNVKLPMPGGDKVSITTTPWVLVGGSYSGALTSWTMVNKPNLFKAGYASSAVVEAIIDYWGYFEPIRQFMPKNCSADVEAVIAHVDSVFTSGSKTQINQLKALFGWQNLTHLDDAAGSLRNNLWDWQSLSPDSGPGSLFFNFCDALEVKNGVSASASGWGLDHALQAWGSYWTTTYYPLRVMKLVFYRKVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGC8</accession>
    <name>A0A2R6NGC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v12822</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="14">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="14"/>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGC8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGC8"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="53"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="243"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="467"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR71308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="556" mass="62673" checksum="93FF7FC1A5B1EBB0" modified="2018-06-20" version="1">MASEDDITVPTPVPNESEPGRKPFSELELSEPTTRALDDMGFKTMTAIQEKAIPPLLTGKDVLGAARTGSGKTLAFLIPAIELLHRMKFKPRNGTGIIIVSPTRELALQIFGVAKELMVHHSQTFGIIMGGANRRAEVDKLQKGVNLLVATPGRLLDHLESTKGFIFRNLKCLVIDEADRILEVGFEEQMKKIISILPNEDRQSMLFSATQTTKVTDLARMSLRPGPLYIDVDKTETTSTVTTLSQGYVVCPSDRRFLLLFTFLKKHMKKKIVVFFSSCNSVKYHGELLNYIDVPVLDLHGKQKQQKRTNTFFEFCNADSGILLCTDVAARGLDIPRVDWIIQYDPPDDPRDYIHRVGRTARAGKVGKSLMFLLPTELGFLRFLKEAKVPLNEFSFPSDKIANVQTQLEKLLQKNYFLHQSARDGYRSYLQAYASYSLKKIFDVNQLDLAKVGRSFGFAVPPRVNVSIGGGSGGTGRPGKRHRDEDGDDNEHWEEIDAVDKDEDALEEEEGLRRNTRRNNPNRRQETLGRKAVEKDIYKKGLERKKMKSEGAQWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGV7</accession>
    <name>A0A2R6NGV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001282">
        <property type="protein sequence ID" value="PSR71478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGV7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="9925" checksum="5734BCEF8D52AFCC" modified="2018-06-20" version="1">MDPSRGLTAYQTGVRVANTANRIEQLSQTANASAYAGTVPMAMQRMLALGFNSHFESANFPVGMFEKNLGESSKFSKSLNSESSRGGLTFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH99</accession>
    <name>A0A2R6NH99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v12388</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001245">
        <property type="protein sequence ID" value="PSR71740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH99"/>
    <dbReference type="STRING" id="98765.A0A2R6NH99"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="17">
        <location>
            <begin position="6"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="313"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="409"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="718"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSR71740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1193" mass="137503" checksum="1D9D93310088901C" modified="2018-06-20" version="1">MASLNKLAIRGIRSFDDKQISIIEFFTPVTVIVGHNGSGKTTIIECLKYATTGDQPANTRGGAFIHDPKMANEKEVKAQVKLRFRAANGMRMLAVRNLSVTMKKTGAMTMKTLESILAVDNDAPKSSKRSAISTKCAEMDAEIPHLLGVSKAVLENVIFCHQEDSYWPLSEPGILKKKFDDIFEATRYTKAVDSIKALRKERVADLKTEKERLNGLSREKSDADKLRARITEMHSTIAAKEIEHEELKRGYDILVSANQKFYDSATRFREIYVQVENLQEKKKHYQEELDSARENFREISGTEEELAERLRNFDDHIMQQKRKRKSEESKMEDIEDELKRTRHAHSAKLTDKGQLEGEAKAQEERLLKREGIIREVSTKYQLQGYDHSPLEREKIVEFIDRLHALQKRQNQETDKLQNESKQNNDEYNSKSQQLHAQLQRSKTQKESCRESLTNLNNQISTTEREVDAAAGLSSRLRTFEVDIEEKQSRIQKIEDEMKAANYDERLGEKNTKIRNMELKRDELNAEVLTLSQQAESRARLELKREESRARTSELKNTLDINNSKFRQFVGADAQAETMEQEVERVLMEKERENATLQTSSDTSGKNLQTISMALSNLREQVKLKKAQIKDLDTKIREGLEDQFTSTKEAIEDTQRELASREEELHKNEGAAGACDAFLRTGRTKKHCALCERTLDERTLLVYEKNVNVLMEDSSPAKVKAAKEDIRDWEQELKRVQALGLLAAERDKLKSSEIPVLEKQIQEKEAELPSATKVAEKALERLNEVKQELVEIAGMKQHAISVSKLHREIQRLTRDIASIESDLLSTGSTKTAEDAQRELESIRDEIRTNERERQALTIEKERQVKLQRSHENDLHALQMDLNEVKNQLRDKAAMEKRIEQMKSEVASTSARLKELDTAIADAEAPIQKLNQEHRQQELAMSRKITEAQRTSRDLNMDVDKLETENKAIERHVRDKRGRLLTETIQEIEDLQSKIEDFNKDLESLRAVMNAIDKEINQSGASVANLRENIRVRRLIKDIAATQAKIDTFDMEEAAKAKRNFQEKYPIEKQRETDMQSKYAHIGGELSTYEQQLKVFEDDMKKRYTDIGKKYRDQLIKVKMSDMANDDLEKYAKALDNAIMKYHSLKMEEVNDTMRHLWNKTYQGTDIDGIKISSESEGGATKKSYNYRVHDKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI04</accession>
    <name>A0A2R6NI04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v12118</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001229">
        <property type="protein sequence ID" value="PSR72014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI04"/>
    <dbReference type="STRING" id="98765.A0A2R6NI04"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="565"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="369"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="523"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR72014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="642" mass="66932" checksum="AEBB244F0E626272" modified="2018-06-20" version="1">MASLAPPSPTPSPGPANGRSPNFRASMGPSSARPTIATQGLQPASPRPGGVSGVGRPTSELLSGTAMFQTPEAEAIDQWFENLQNYEATLEEMAAASLDVNFKEELSAIEQWFKVLSEAERTAALYSLLQHSTQVQIRFFITVLQQMARADPMTALLSPAVGGSMQSQMEAKLASMNLKSPGLKSGLPGSPTARNFSGGMSNYLSPDSASLASGGSDPAATLAQQRAKLKAASNAVHRISAPALGSAVGDRNTWGSGSNQLGQVDERSSSPGQELTVPTGNSRPKSTDFSGVANAFKSPRLVDDALSPMIGDSWASMVNTPLMPMFAKERNPNQSLDAAAAKLNDWANTSSNGPGVPLISDPPKKYNRLSKGNEGGQNHNGIYGDDGNLSVPGSQGQQQRNVSGGFRNVSGNGNPNAFGGQPGWNGARSPALSNTSGRFSDDGSMNGLGVGGFNVGMGAGLGMGMPTAPGFNMAALAGMAPMSPFNNMFNMPNLAAMGITPEQLLAMQMAAAGQLGQAGLPGFGMGLPTGNSPGSRNGRMNMRSPGVKSPSSRDVKKDEEDVDPKVLEDVPAWLRSLRLHKYTPNFEHMNWRDMVAMDEAALEAKGVAALGARRKMLKTFEVVRKKMGIEAPGSSGSATSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI76</accession>
    <name>A0A2R6NI76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001216">
        <property type="protein sequence ID" value="PSR72095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI76"/>
    <dbReference type="STRING" id="98765.A0A2R6NI76"/>
    <dbReference type="OrthoDB" id="3268553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="273"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="521" mass="58710" checksum="1AFB92867C96D668" modified="2018-06-20" version="1">MSGQSRTSSRAAKPSEKQKQIEAEKTAQSQPKPTPVPRKERAVNEQVRKASTGSFVSKTVKLVKKVVTPRATSQGTTPIQRAPSKKQPTADPPPKKISARVDHGHARDTGAAKRSLPPLARPRPPPPPLHAQAPAEEQHDEMPEGLEFDDDNADLPDYEAGPPTSSACTSDLEPEDITEDIEEEDHQPRPARYISQYSSPSPEPQDRLLPDDLMASDDDIQELAVNSSKRPRSPSTDDEKLPPTPKAVKIIDHSGRARQQDYDAVVKHIIKTAIDLYEVKLLTVSAFPSQLMEADWVTEVWTEACQHEGVKYRITPDLYKMLTRRGTHLRSELKIKARKTVAMYYKLKPGQSTSAKEKNKRLIVKLLQETGPDRNLFIYPVKEQAREPATRQHIYRHPAIGNIINEYVFGDRNSLGVRYTEYFGDQLPKPTIALAATFIEFCLKEWAEGHFDDATFTVSENSTIFASHLADLDKFQRLTMRFDLYRKLATKLLTNARRVLPELNDHICINKAYFLLDTMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ55</accession>
    <name>A0A2R6NJ55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001223">
        <property type="protein sequence ID" value="PSR72042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ55"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="11201" checksum="3CC359129803EDE7" modified="2018-06-20" version="1">MRSKAWNLRPKNEELQHKKTVECGLVLETMGTYAKAAPEHTRTTRRHMPTKLMFFAKAAFPSRDHRTWLKTFAMQIYTVRYHGIGVSPNMQYSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJX2</accession>
    <name>A0A2R6NJX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001196">
        <property type="protein sequence ID" value="PSR72312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJX2"/>
    <dbReference type="STRING" id="98765.A0A2R6NJX2"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="43"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="638"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="82784" checksum="C3351E78204D6ED7" modified="2018-06-20" version="1">MVSQADQDTTVPTGDISSSDYAKRTRLLIKLITDLRALGAEADFDLPRIAVIGNQSAGKSSLVEAISRITVPRASGTCTRCPMECRLTYHPGPWQCQVLLRKDTDEYGNKITTKEETFGPPLSNESDLEDMLRRAQLAVLNPSVPSNFFVDFDTSSLKAGEKPPGSSKQLAFSNNVVCMDLHAPDVTDLSFIDLPGIISNVAKGEDPGNIEAVKSMVREHIKGNTLILLTITMRDDIDNQGAAFLAHEEDEKGLRTIGVLTKPDTIQHGEEQAWLRILEGKSHILHHGYFVTKQPSPKELEDKISYDVARQRETEFFENIHPWSGRSDLRKRMGTANLTKELSKLLGNVISHALPGIRTQAKESYHSVRQQLDALPPPPSENPAAELLRLVTEFSAEVEHLIQGRESYERLIQRCRPAYSNFKKLIWSTAPDMRPYEDEDKENMARCYEETAEEESDIGESTSNPVYLKEVRRHIQSSLTRQLPYNVPFSAKVALIERFFKDWESHYLRCFAVVHEATLDELKQLVEHHFGRFTATPLLDHVNSIVEDQVEQCRARTIEKMQWMLELENPPFTNNDHYFSSNRDKYLARYKEVRAPTPALTNIAKVNEALAALAMVGYPGLKQEDLPKLRGTDEYDEELIVMAETSAYFHVSYKRIIDNIPRIIDHDFLRAIGKELQSSLITGLVLGTEQATDRASMYLAEDDQVAYERVYLTEKKKRLDGVLKKLYSFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKW5</accession>
    <name>A0A2R6NKW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR72993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKW5"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10684" checksum="BF38EFF12BEB0A79" modified="2018-06-20" version="1">MLPLTAILFFDYLLTLADEVRLFWVPRRPSFVVMFFFAARYGTILGHIPVVVGQVGLLGHDALYAVVIFLVDGFVAGGRDRNTYFHRFAASIGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLC0</accession>
    <name>A0A2R6NLC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001100">
        <property type="protein sequence ID" value="PSR73180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLC0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="102" mass="11647" checksum="50D836DA2E533364" modified="2018-06-20" version="1">MPIDLHALTQAKTHLAKVTRDINLVEVEDDREEEIDSLVNGLKFDSDVLAAGAMNQDNPAYLQPQSDLSNKRQKVTIEKYMENFKRASAQVLVENTIKEYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLM5</accession>
    <name>A0A2R6NLM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001094">
        <property type="protein sequence ID" value="PSR73257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLM5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="26974" checksum="99336717741D130F" modified="2018-06-20" version="1">MNVAAQLLNDTLDSPRYSDASYIDWKVWMKDAVLVLLSVLEHLMTQESCRTLVRCTSSPEDRQSVIHQLLLFSWDPQNMAYEGYRCVFERLHGASSPLMLFRLEETTSGAIDFIQSSVCNGGCVHGSGLGEIIDLSPKAETGMWGHSLYRLIDKLEHFQTLRIQLEQDNVSAIVAVAGQCLDLLGSQPGRSAIENFIKDVSRAAVYQRCFPSYGLEDLIRGLKAFIPDNKVSQYPILDTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLQ7</accession>
    <name>A0A2R6NLQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001094">
        <property type="protein sequence ID" value="PSR73259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLQ7"/>
    <dbReference type="STRING" id="98765.A0A2R6NLQ7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="98"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="352"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR73259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="601" mass="66155" checksum="1B54D55911281286" modified="2018-06-20" version="1">MASPLADTVVLVGADGRVSIQSSVSAALEKDPELAEAFTHEEEAIELDDDDDDGIKVVKTSDGKLIVSEEVEEGHVGIGAFMLFLRALGGKWPALFWIGYLISNVMSGVCDAFEVWWLGWWAQQYVLRGRGEVYVVYYLTVYSLIVFAAIVFQVSATVTWTYGSVRASRSLHRVLLDSLLRSTFRWLDVTPTSRVVARCTQDIQAVDEDIAQNLESLSDMSVNMLAKIGAVVIYTPTFIVPAIVISALGGYLGQVYMHAQLFVKRERSNARSPLLGIFGEAVAGLASIRAYGAQHAFKEETFKHIDHYVRASRSFFNLNRLERIQQYLVIEHEPKAEDGGKPPAYWPSSGDIRVKGLSARYSPDGPKVLQDVSFHIKAGQRVGIVGRTGSGKSTLTLALLRCIYTEGTVWYDGVATDSMNLDDLRSNITIIPQMPELLSGTLRHNLDVFGEYDDGVLNDGLRAAGLFSLQRLQDENRLTLDSKIAGAGSNLSVGQRQIIALARAIVRRSKLLILDEATSAIDYETDAVIQGSLRSEIHKDVTVITVAHRLQTIMDSDLIMVLDAGRLVEIDSPQVLLRNGDGLLRALVEESADKETLFAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMG7</accession>
    <name>A0A2R6NMG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMG7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6159" checksum="56200592BDE7E5A3" modified="2018-06-20" version="1">MSMLVRASLRQVAARRFAAPSRGVHGEYNAKIIRSGLVLWDTTYTLNIDLEVSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMT6</accession>
    <name>A0A2R6NMT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NMT6"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="126"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="690"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="909"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1323" mass="147387" checksum="42737C863FB8D63C" modified="2018-06-20" version="1">MALAYSPRKQVVPLAAGDDRPSLRSSHPTLTRRVYFCGVVVENADNGYELPPDVQDLVASLGDPLYLDESSSSSSNTDLLQAGNDPYVRKRAISDHSSSSATDYSRLSESSRPPPIRKRSNTVSNALIDITNELVATERSYVNRLRSLKTDYAEPLRFFSKNKDTAIIPPYEAKTLFGNIDQLLPINEAFLEDLEKMVAPGGSEAVGGVGDVALKHFKDLKGFENYKQYYAKREEAQGIFEREMRKASGFSAFVDRIKYSSPDNRNRVGLRELLMDPVQRIPRYTLMFRTMIKEMSPHDPQRAKLLEADEIASKIALAETDEQTKRAAIMYCLSATVEDFPPALISNSRKFVDCIDVDDVLLPDRTSDPSTSVAGPNAGTLHCSLLLFDDKILILKRPSGEKGVRALTGLDDLDRSHKSKGIPMGMKKAGLLCKGVVDVTEVTASDVGGADFHLFFESPPQGQTERWSGRPFRALSVVHPPFPINLEPRRTETDKTRFLENLWAIQARYRTKAGQSVVLCAEEKEVENRGGRITKAKAYFNLYQRTEFLKEPKKTKIVLHIDPLGTADPIPFGMNGPPYVVVKVQPMAGELARYTVKSGDPNDEGEEDIVQTARVPGRIIQTIHQFGLFNFRTGNNSMPSTPTASTRSRAAIFGLDAISRNLFHSRPGSSKDIFGGSINGHRRSKTSANSRSSMYTQSTSSGESSMSRFTRSRSNSTTATTISLMDDDISERSGSRSSRRSHSLSKAKKFIKRKIPPSAVSDGSGSEAEGSEERGTSPMSVPIDGSFVRSPSSEMETDFSDYYDEREGLPSTRNHQVDQSERDLAARLALARKNSQSQHESQYDPLILDRPLEDTIYEIDAAAYRRPLSRASESRELPELPPEARTRPITPRPDSTTPTKPTDAEARSRPLSRPLSRQSGERPLHGPRTPSPLPPSRTRVSALPSMDDDLAHEHTLVNAPQLVTPKRPTRPVSPLPRSKRQPFDVAVHVEVTPKAANSDEGMKPPSSVEPLVIRRKTSMQFNGSPYRRRIYNAPRNSPLTKPTGRVGSLRRTSSQLKHNRMATPSLSGEDLEYIIDLAVDTQESMESAYRSIRRIKIECERSTTVSAIGTPPVTDRDRSPSPAKGILTPPRSTPMTREAQARMEEMQKVIGKRMTETVRPRPLSMATESSLSRLLESPRTDIIVRSVDELASQADADLSKAIKNEELIQGHLKALTSLLLEKSNELEKSKLDLQNAKRQCEVVKRLFDDCMAEKEIMYEAFNEELDGMYNDANLPEDESWAAITKDLRQTKEARNTLSKENSVSWLMQSYRRKNYGLCSKQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMY5</accession>
    <name>A0A2R6NMY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NMY5"/>
    <dbReference type="OrthoDB" id="3044497at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="492"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1316" mass="149802" checksum="BD1C5B6847C24DEB" modified="2018-06-20" version="1">MLDPDKYELALIQEPYIDWLGLTRANPKWSVIYPTGHRDKASKDKMRSVILVNKRISTNDWDEVDCDSTDVTVIRLRTPSGPLYIFNIYNDQTHDRTIGKLIGKMVAIEREETERGIGEGANRTSQIAHIIWAGDFNRHHSFWERAENTHLLSRSYLDAAEPLVTALATFDLIQVLPPEIPTLQANATGNLTRPDNVFASPGLAERLISCDAHPALRPPNTDHFPIHSNFDVSLTAAQEIPGWNWRKVEEAEFYLALDEAVESRHIRKRRIKTREEFDQVLEQLTDALVEAREKTVPKRKPSPFAKRWWTADLAKTRFRVKRLARDSYRKRKEPHNLIHVEYKKARNEYGERIRKAKKEHWEAFLEDVDGESIWNFSSYAASEHTDGGRTRIPQLRSTGTHGRTKLSKSNDEKSKALHEAFFPHPGNPPSNQDTAAYPEPAFEFKGITKDIIREVIKNLKRYKAPGIDDFPNEVFIWCEDLLTPILFLLFQASYELGIYPDFWKISRTLVLRKPQRKDYSLPNAYRPIALLICIAKILSACMAKILAIQTERLGLLSNNHFLGRMGRTTTDSLHYITATVKNAWRTHKVASILFLDVQAAFPSVNPERLLHILRLKGIPKEIVDWLRLKMTSRRTVLCFDDFKSSQFEIKGGLEQGCPLSVILYQFYNSELLEGANRKNGEIATGNIDDVAVVAIANNFDDTHEILRSFMTRRGGAFQWAEEHNSTFSVGKFGLLNCSRVLGDLGPTLKLGQTTIKPAKTHKFLGILLDNKLKWQAQTERARDKGLQWLTHFRRMANVKHGISLRISQRLYFMIAIPSMLYAADVFLTPIRAGTHPSNKRTGSVSAITRLSSVHRQAAMMMTGAMRTTATDVMEIHANILPFPLLIDKLCHRAFARLCTLPETHPLQPLVNRAAKHYPRRHRSAIQELAHLFNLAPGAIETITPARYSPYWKPGHATEIAENKDQARESENRWARKDGIRVYTDGSDVDGGVGAAAVLYKPGRRQVKTLQYHLGPSTEHTVYEAEVVALILGMELIRQESSVRNVSLAVDNQAAVSASRSSRSAPGHYLMDKFHRLKARVKLKHRGAKITVRWVPGHMGIKGNEAADRRAKEAARDLMEIRRPIPTCLVKALPRSVSKIHQLHQQELVAEADRRWKSSPRWAKMNNIDPKLPSKRYGVLIAGLPRRHASILFQLRTGHAPLRKHLHKIGRADTPTCQACGEAPETVPHYILYCPAFNHPRAAMSFELGDDARSLTSLFTNAGSLRSLFRYIHRTRRFEEQFGGMSLPPAKEIREKAKKRGLKDTGKEKQKKRNEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNU8</accession>
    <name>A0A2R6NNU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNU8"/>
    <dbReference type="STRING" id="98765.A0A2R6NNU8"/>
    <dbReference type="OrthoDB" id="3254913at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="19328" checksum="61E3BDB6ABF7C666" modified="2018-06-20" version="1">MNSQGSQKRQPEDQHYLGSVPRTHHRVDQSDSDALRLFALSNVRTMHARKRSDTSYVDTDDGASILSDSPLPPLPEPRLPDLDLPQSELDLTTTFASILAESEDTHIVPEAEPEMEKVQKRASNVLKLSMENEKLKAELRAMNERLEAAERRQQELREAAERASKSNAQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPN0</accession>
    <name>A0A2R6NPN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000988">
        <property type="protein sequence ID" value="PSR74456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPN0"/>
    <dbReference type="STRING" id="98765.A0A2R6NPN0"/>
    <dbReference type="OrthoDB" id="2754445at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317:SF40">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36471" checksum="F16CDAEEC5546899" modified="2018-06-20" version="1" fragment="single">MSPDSLLGMSRISGSDAFKFPKLTGSNFADWSESMKAALQARYLWMLVSGDETCPLKPDVKKPDTATAAEWKAEKKEYLDWQQRDQAAMGLMKGAVESSQMPHIRDCVTSKAMWDILKKVHVTSHQIVNIHYWFEDLYTRKYTDGTPMADHIAVMLDLKHKITAAGEELPDSHVARALVISLPRTPSWDVIKIQCFALSKDKFTPENVGSTLQAEANRVAREKGSGETALFTQRPPKMRKRGKGKGPQPGDECRYCHSKGHWANKCMKREEDERKRGDGSTAHYVAGSLQDLGVREVGQVYMAVQRGSTKSAQREELLLDSAATSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPP8</accession>
    <name>A0A2R6NPP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPP8"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7386" checksum="E67CB73492751B29" modified="2018-06-20" version="1">MPRAKRRTALSQVSIHVYDDDDDVGIENHLVKVVNGEHRIGVYAKRNIPAGTELFLDYGPEFTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPT6</accession>
    <name>A0A2R6NPT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000986">
        <property type="protein sequence ID" value="PSR74460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPT6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="312" mass="34974" checksum="69E9DD0EB355FDB0" modified="2018-06-20" version="1">MALLLVSIGQATDKDFEHDWYHPYDWTLNFNACRWTKAKDGDYRFSVYPQARLAGLPVEIAKSSNDITIGSRAQRGTGVEPEGSGSHTIAKNLAQLRVSPSSEAASEAGPSRVIAGTSSQQQDGALRRSERLLLLHSEGSEKQERPTKRPPVSTASTVPAVAKSLDEYTRYPDFVVTMISSGGLDSLHSIWELKRPSDGLKMRSPADDCMDAYALDEFNVHLLQVIEQVECAFSVYRHQNKMFVFLALGCWLRYIRFSRNKMPSKETLDAARVPGLKGREIVALLRPYARQSPPFYLLNEQESDYSSLFKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ15</accession>
    <name>A0A2R6NQ15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ15"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ15"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="26002" checksum="97636E505486C59E" modified="2018-06-20" version="1">MVTPSHARTTSFSQQQQQSQQYAPYPSGQTQQQSGYYPQGQDPRNLQSLSSVSYDPSSGAHIPRRSSMSVDRTVPSRMSTHGPVPYARIPPVVSPTYDQEPISEPSIKKKRKRAGERVPQMFGKVVWKLTFQNKRQAMRQNNRQASNALPPTSSEPFTAGPAPNPGANAPPSSSGYIQQPSNPMNSISMSGPAYGSQRVDSYGRPMIPSPTPSVQYRGRSYDDHETLRRPSSRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ44</accession>
    <name>A0A2R6NQ44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-methylcitrate dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ44"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ44"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="283"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50294" checksum="F8E850D161E150A2" modified="2018-06-20" version="1">MSHAAESAVRPEPDQVLQDIADYVHNFKIESDLAFETARLCLIDTIGCGLEGLRFSECARLMGPVVEGTVVPNGTKVPGTSFQLDPIRGAFNIGTQIRWLDFNDCWLAAEWGHPSDNLGAILAVADHLARQGQPLTVRDILEGMIKAHEIQGQLALLNSFNRVGLDHVVLVKVASTAVVSKLLGLDRAQTIDAISQAWADGQSLRTYRHAPNTGSRKSWAAGDACARAVNIAYLVKKGEKGMPSVLSAKTWGFYDVLFKGKPFQFALPYTSYIMENVLFKISYPAEFHAQTAVEAAHILHNQLKNLGKSSDDIKSIRIRTQEAAMRIINKKGPLDNFADRDHDINYMVAFPLIFGELTSQSYTDVSAADPRIDALRAKIHCVEEQQYSIDYHDPSKRSISNALLVELNDGTVLDEVQVEYPVGHKRRRAEGTPLLLAKFERHIAPHFDAARQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQK2</accession>
    <name>A0A2R6NQK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQK2"/>
    <dbReference type="OrthoDB" id="2803116at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="100"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="34969" checksum="12F3B9951D2691C8" modified="2018-06-20" version="1">MNLDPNVVGESPPIETDACVDAWRRKAPSSTYVFFYDLASMHHAHSNSPAYLKTPSIVYNEPARVEGIEQNEPLPQDVKEEPEPPPLAELQDDPEDLEEERALSRYNRLSNAWLLFAGFFALLTTMFITNLTNHPFKRKLILNHESLVMLTQWSEYHHHIPLQNALALYNATYPTYAHPPLEGTLTAEIRDVWVPALWYSSLILTLMGTMLALLIKHWLMGCTMLLYGPYDDSASEGKSRVIFLFHRWQQYKERRKKFKQARKEALKKTRAVIRGLPMLVYPAMGMFVLGILAKLWTAACTMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQV3</accession>
    <name>A0A2R6NQV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000942">
        <property type="protein sequence ID" value="PSR74952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQV3"/>
    <dbReference type="STRING" id="98765.A0A2R6NQV3"/>
    <dbReference type="OrthoDB" id="2728219at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="284" mass="31181" checksum="721EF85E28115E71" modified="2018-06-20" version="1">MLQGTCLSEALQGFLSLALGEAELQDSEDGAESEDQQGDGNTVDNGDEDGAVEGPRVLGDVSLARQPERTYPRTLPELGLHCGVPNLPFLVSSFLYDQTHPEPLPDGSATPPCPPVQSVKVYHSAAATFYAPSDISGIGGMRRERIRATPSWFKGPARYDCVFAENDSTVEGFRGLHAARVRTFLSFKSGGVEYPCALIQWFSPVADEPDELTGLWVVEPDFDQDNRPFYGVIHLDSILRLAHLIPVFGNAILPPDFHQSESLDAFKTYYVNKYADHHAHEIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQX9</accession>
    <name>A0A2R6NQX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQX9"/>
    <dbReference type="STRING" id="98765.A0A2R6NQX9"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="7">
        <location>
            <begin position="123"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="329" mass="37321" checksum="E1062D2316849079" modified="2018-06-20" version="1">MLAQRAARHVFRPPALRPRFAHKELNRPRTFVTEAIQSLSNEFLDLALAIPYPQSIPPYSGTIILVTVAKKRQWRAEELALPQLQQEKPEILQRVHQDMHKDGFRGNKEEAAMEHSKRAEPLLTTRRNELFKKYKCSPTATMLIGPLTQLPIFVSTSLMLSHASQPPTVFDSESFFTLSSLAHSDPTLTLPIVLGILTLANVESSRWFISAAALEREQKVAEWNTKKRAMGHTVIEPKKIVQSTLRVLAVARILIAALVPGSIQLYWVTSAVFGLVQTWIIDWVDHRRRKFRALQAPEPVKPVARKEPASTIVFKKVKTESKLPKPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQY7</accession>
    <name>A0A2R6NQY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQY7"/>
    <dbReference type="STRING" id="98765.A0A2R6NQY7"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="13"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="43673" checksum="541662DDBD907CBD" modified="2018-06-20" version="1">MLGYYEYFPQKRMNVSVKETGESKYKILVAEKDFEAGDVIYKEDPLVVALDSDLQQMGTHCSHCLRLIHKGMAIKPESDRLNAIYCSKECQVASKAESQNLLFTLESPLPPGMDQGLSSLTKPKREEAQKVFTDYLKSTGKTNPLLLARLLARQISLETAKFTPNQPGGIVEPPLTDEGSPGYGISDHIERLRYIDVNALEAERKMITEVLGSALPGLESTLPEDKHALAMGKIAYNAFGVCYSGGRDDKPVSTARPEDQERTRTPYGTSRQIGSGLYVVSAYLAHSCEPNVRPSFSSGTAELHLVASRAIKKGDQLTMAFVDVTQHPDETAEQARRRRRFELARGWRFKCECSRCVSDVTDEAEGDLGVGRDESKVEAAVSRVESGQAGIMPDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR15</accession>
    <name>A0A2R6NR15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 79 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR15"/>
    <dbReference type="STRING" id="98765.A0A2R6NR15"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015358217" description="Glycoside hydrolase family 79 protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29084" checksum="58183EA57B83296A" modified="2018-06-20" version="1">MAFRNFLYLLQLICAVTLSLAATVQVTPPSAPPSDNVTTVYSNFYGISLELSFINYYFGNDTSSIPQPVLNYLSALHNRTDGRPVRLRLGGNSMDSSTYIPDQQQIIEFTDPTANVNDQPVSYGSVLFDVMKATSDTIGGVDWLIGLSLRDPNSTNTPLVAGDAQKVLGDDLDAFLLGNEPDLYTSHGDRPGMANYSVYDYIGDYWVTFGNLANTSDGDVLSLDKIAGPTICCSWDLSAVLTSGWLSDFNDRLKYITLQHYPQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSP8</accession>
    <name>A0A2R6NSP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v8845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSP8"/>
    <dbReference type="STRING" id="98765.A0A2R6NSP8"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="107"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="227"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="608" mass="66126" checksum="B81EB552A3498B3D" modified="2018-06-20" version="1">MLAETRAELDEFQVSSKELEEELERELERTEKAQQDLQIKVSRAEHEKDDWKSKFMTLQTMHNTTTTSLQRELDTLRKEYQTIKIQLRDLEMGNDDLERNERAISSSLADVEQRYSRVLEEKILLEHELIDKANVEEEFQRLKDEFRDANEEIGVLREQLSAAHDRAPVEIPPSAAPSATSHCSDEEESLTSIPVPPELRLSDLTSPSPTSMKELPRIIGASHTMQHSTPSSSRSPSALHRSGLQRPTLTTSPTSIPPALARSSTIPFTHMTPTRTTPRTPLVKPPPPRNSTAMSTTSSTAGSVAAASTRSKGVQMVSEMRARVKVLEQKIHTRVPRIRMGSVTNRPVASPSAMPPPLPPKAGPSGAASSVASSSNSSLHSQSPDKTVTLKPRRQSLDREVVKSRTPVGDASGWVLIMEDSPSPVRDKEKELRRLSGPTAPSAFRPLTSSSMSPPSSSESRVPSALSQSHMPSGLRRPNSRLSDGRSSISTNATTSTASSIPTPISRPSTPTFLPVPTSGLYASTAGLKRSTGPSSGAYSQPKRSSLGSKEPLLYKPPPKLGSPSRAKRETYSGPTVKKSGDDFSDAQVKQVRGRAGSASLLFGRHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSY4</accession>
    <name>A0A2R6NSY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v8993</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSY4"/>
    <dbReference type="STRING" id="98765.A0A2R6NSY4"/>
    <dbReference type="OrthoDB" id="10265862at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00755">
        <property type="entry name" value="YgdL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000125">
        <property type="entry name" value="tRNA threonylcarbamoyladenosine dehydratase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267:SF2">
        <property type="entry name" value="TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="14">
        <location>
            <begin position="97"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR75702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="476" mass="52935" checksum="5FF1D025C2622728" modified="2018-06-20" version="1">MNFDLHSHRTQLVLTAVAASAVTAGLFSAYTQHTRRQKRRDLNDEVLRSLASKEAQGKSALASTSLPGSIKSTPAGDRDALVLGASYSEELIREQLARNYAFFGDEGMGKIRQGNVVIVGCGGVGSWAAVMLVRSGITNIRLVDFDYVTLSSLNRHATAVLSDVGTPKVACIERTLKQISRWVRVDSRVDVWRKEQGGVLLDGADWVIDAIDNITTKVDLLKYCHDHGIKVFSSMGAGAKCDPTRIQISDISYTMYDPLARSVRRRLRLQGVSSGIPVVYSTEVPGDVKLLPLPQEEFEKGDVKELGVFDDFRVRILPVLGPLPSIFGLHIASYILCEMAGKPILNPLAVKGRKKLYERLYRDLLRREEKAAGHAINRLPIDEDDVGLVFEDLHRGRSIIPPHPVPSRPTLVRWDPSQPLSLENCVVMEHGEVERHVKECFNSTPAKSPEELWGQDVAEVVVRRAKEIKQDRQYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT13</accession>
    <name>A0A2R6NT13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000861">
        <property type="protein sequence ID" value="PSR76116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT13"/>
    <dbReference type="OrthoDB" id="3362336at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="416" mass="46174" checksum="80940FEE160EE256" modified="2018-06-20" version="1">MLPLSPSRCAGAIVRHSLRRAQSTITSSSGSQLSDEFKPKRDRPSRGAAKSLLVRTRSRGIGSMSEAFALIRALEMEYGKIRDIDMGRDPDSEELYNPNFYVSFHNEEILQRIAKLDTETTQLHIPAFSPQPPGLVGLEDLDGLLSPKDGSPGDADPWADVTGVPTAENARRPTKAIDVKLELSSRPTGYKVNREPTNITQGYLQSASRELAQWGGFYNPALQPRRSSADEGSASPISSESPSSKYMQAVQRKWKITAIEVRSNPNQEGLRNLQERAEEAPEDSTMQSVVDAFMRVELVKDTAIADNSPPPQEVALEQNATAITPSRSSKRERILDLAREQTKKKPESGSRASEQERLLELAQQHASKPLPESVIPKSPEMEQEARQNEKRAKRAEEEQAKSTLRHRLSKLMGGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT38</accession>
    <name>A0A2R6NT38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v8632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT38"/>
    <dbReference type="STRING" id="98765.A0A2R6NT38"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="10">
        <location>
            <begin position="68"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="9">
        <location>
            <begin position="233"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR76134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="369" mass="40287" checksum="CA15D35307737144" modified="2018-06-20" version="1">MSHVQNRLAATASRIASVSPAYLKSFPPKEAFAPKPSSSQSDPSVEQKPHFFDAETWASLQPPPPTSLTAFAYRIGLGKLVSSPDPILQACTHPSFLPLHQKHYPHHSRPAANERLAVLGNSLMGLFATEYVNSTYPYLPTRVMKAAVSAYVGPTTCATIAKEMGATPLLRWNRVSNTPTRPAVLHQDAMSSIPRALVALVYQHSSLLTARTFVHKFFLSREIDLRNMIKFRDPKKALLDTVAKFGRERPVSRLLRETGRLSNSPVYVVGVYSGADKLGEGFGSSLKMAEFRAAEDALLRLYLARQPPHLVQLPTSTFPNKTGSIFKAQGGGSLYVPVQLGDAEIKYGAADKTGLRSPGARSVASFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTG2</accession>
    <name>A0A2R6NTG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000850">
        <property type="protein sequence ID" value="PSR76325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTG2"/>
    <dbReference type="STRING" id="98765.A0A2R6NTG2"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="448"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="850" mass="96814" checksum="8F728079FD31F076" modified="2018-06-20" version="1">MPPVVLQDTEALPPEDLTKLLFEPGLYRGVEGSHPRVNMASTLVTAHNNDSVHPYVKEDLIYSTQDIPYNRWLNAVFNLSPQKVDAWVAHIIRFKWFQDAIIQKALYRYSMAGDEHTLYDPFVCLAKRILELARATKLPELDGTFPIHDIELVSTYKKMVRTIPEHDGLGARRYPDLLLLRAVHAKKIPPQGKKAASGILWADILAFFEVKYSATDTADMPSLFKSTLENRGMKFPPTFKPTKSQQTPEPSTTTSNRKAGSGRVHTDATHDSSSEESASEAGTLSRNEDQAPRAATKRARSSKSSDTTLHGTRSKKSTSSQASVDGRVQAGGYALEVMSCSYGTRLFCLGNIIKDDKMSMWYYDASGYIRTRETLSIFEDFEKVAAVLVAFASCTPSQFGAMPSIIKPPSSAPYPRSFPPASLQGHTLTIKHPETSENIHVTLEDPIFAQYVLVGRRTFLYGIRTSPVQRKKLIIKFSYQVRARQAEQELVKKACSAGVEHLPEIHFWADLWQMSDGVRKLFYEDEKELPFQDRTLRAIVYTRYTPIVELFSKSCEFLPLMVDQMLDCLHDLRYKANILHRDVSKNNIMYEMRDNRPQFILIDYDLAKEVIGLDAFRRSSTGKHRTGTLPFMAYELVKDIARYGEPGHVPVVHRLRYDFESLFWVALWCAVKMPPSRDASEDNKLHNVVKEWESGLLTMLASHKRTLCTTPDEVNSLRLPPNSEYLRPWFRSWCEVMKKADLRLEEYKEALKKPSRLLPFDMETVDGLLTRDTIKEALAGSHICYTLEQLVELQETDEVEHAVTNGPYDEESNDYQQARRCCSLSWFLDWCWPELANYPLALDTIPSAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTQ4</accession>
    <name>A0A2R6NTQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTQ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NTQ4"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1150"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1159"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1225" mass="134933" checksum="CBF6B3771A32F864" modified="2018-06-20" version="1">MVLRIPKTLDDRSLLVDEPFGSHFARRIASSSKELRRRKGQSPSPFFEQIEAEMRTEGTGLDAAILWLRFAFQVDAEEAARPAMLHIFIEFYWLLACGKDRDAEALLQKECKARKFLWRTDTSKKVDQTQMPLPRTTNLAKRPKRQPEDVYDAEPEDNNSSFLDNDIPDSLIAIPTTGSSCQFPTRSQTSGRLMTKAGVADPTSTEPKSKGRAKEFRGKGRGKKRKAMKAHPSSPSATSGDDVPLAHAKSTSTHADSGVVPLDAYMDWDSPLTSLASDDSHGEDEPEMNSALISSSPGGLMPSPIQELTAGVESLPSATPQPVPGASTEQNSAPLAELDLIRQGIPAPTQASPMELMPAPDVKSPFRQIPHRRAANRQKLSSMMEAELKHEIHLRRRKKRLVHSSSESDLDIAEKVPTNSITKSSPSRIAAPTAETPSRTQALSTKGLPAAAKERKRAQGKRPKVPGKEITAGQPFVAEDNSPVVGQIDTIASPSGAQDETQADKASHGSSTVPLPHRPRTAKKPRIFHNRKGAGVETQIAKRRRGNDGMVWSGHLAQTMMACSKVHRDKPSAVSNGPVNVEAPPPKPVVSNLEKTGRKRDREEEDNGSVLSEGLMQNVIVQKSQRKVAPLPKHTTLMKAARKRCIPAPKHFLPPTTQTINTLPTMDSVIRDAAIGAHQSLNSVVDQASDWEVDEPDDHLIDESSEENIPLSTENSRNLSSSVVADLPEITDIISGQSQVNAREEIIQCSEPIPIPSILPGASTSIYQVISPRPPLPAYPPIWSQSRQEVCESFDWFRSYQGGVYFVKDLVKGYLLSAFSASRDVFYDDGKLIISHGGGRAESLHKSHGQIETHQATDQLEDDKSVRALLRTYRMQRPLALLIDDKYALFPFDLSSKGCTYVILGWYYIAHAWAEYQSASNSDGRVIRYKFAFRWCAGQGDPWWSVPDSLQLSDTCMSAPISCRPSPLPSDPEDCAAEVTPDSLQNNLHTGPPSYKCQTCNHSSEQVYAEGWLCLRAACKAFWKTSDGQNAPDHLNYALAFLQPTVATVEAVEDLRPSLPVSNIPEDGITTSRHFCKGWHCRNCGRLSSRYKWEHWECRSCGYVGGADNTVTWSDAPTAVTRALGLIQQRMKEASLDETVTFNEVLTAAYMEKQKMAFHSDSERGLGPVVASLSLGASAYMHFRLHSQYANSEIPDGHSRDVLTLFLRHGDVVVMEGANVQTYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTZ2</accession>
    <name>A0A2R6NTZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exonuclease 1</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NTZ2"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0228">DNA excision</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="2">
        <location>
            <begin position="352"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="550" mass="61335" checksum="791EEEE0B1176AC2" modified="2018-06-20" version="1">MPHPYRHVLGWYRIIKELRDSAVTAICVFDGKDRNLAKQLEIERRRESRRMTTARGLLEVERLTRLCKLTTLVKAWRGLDSHSQHSTATALRSLVDSAGLIATDTPLPAITGGFLDQDLDESAAPEPVFEEPERDAHLHTYGEIKQDEVLEIVQQAGVPVSAPQDTDVEPISYLPEFSLALASIEDPRTLPPLQSMLQLSLGDSDDSRAEESCEFIEEPISKSLPTSGASTHVTHITAEDIQSELTTLYLDYKASLSQLQSLQSSTVSVMQPAPEEDHTEARTEYMMSKTQQHLTIEEGKFWDRLAELCVTESDVSSAIALAERSSLLSESYERRTNPPTTDTYNESLEILRAMGVPCLQCRGPFEAEALASSMVLQGYADYVATEDTDVIVYGVPMIRNLSKRNEPIVVVSGSEVRDVLNLDHSSFVDFALLLGTDFSQRIKNVGPQRALKFIRQHGSIEKMLERETQFPPRVPNSAYLEQVAVARLIFQTLPPPPDVDLLAPQEGDEQAVHDILRRYGLSREIPLEAHDSLYTDALAGNFFQDNPFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUT7</accession>
    <name>A0A2R6NUT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000812">
        <property type="protein sequence ID" value="PSR77143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUT7"/>
    <dbReference type="STRING" id="98765.A0A2R6NUT7"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38216" checksum="6DE88999B0347A17" modified="2018-06-20" version="1">MSFARCIRVIPTHRIIAWNPNKDSPVGATCILQEHVDNVIEPWQMWSAWSGFGNLAFAPGLSAVANLADPAIYIVKPLQLRHLWASIEWRRMEPFIGSTSTLHRLWEELWSHHRSRSICGSDVDREILGLYDDNEHCDLASFTVVANIVRLVAEDALRMLAQFPQYAQPCLVNHDYAYRDIPLDPDALQVEALIDWDDVHVMPFVVGIDYPEDIQMFHMYSLASDSNYYREGAFPSFPPDEYGEIIGAVDAHGILTGVDEQGNLTGVDTRDQRITNTVLRETYIRALQKQDARASQSDMWEVAGCGGARENGYESRPTLLVRLERIMKILNAVSTVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV36</accession>
    <name>A0A2R6NV36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV36"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7792" checksum="682649D64B73EE20" modified="2018-06-20" version="1">MVVFSKKLRVVRRLEELIFEFKSRNSLIVSLPELQDKATYELNIVSVPDGGDAISIRLNKDVWPCEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVR6</accession>
    <name>A0A2R6NVR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000779">
        <property type="protein sequence ID" value="PSR77733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVR6"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015353344" description="PLC-like phosphodiesterase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="57228" checksum="C3846320C1FD578B" modified="2018-06-20" version="1">MGTFPNLAGLILAVTMLPLLAWAGEGGSFVLINMTPYNWNQIYIHSDQMNAWGFPQSVPAGSMAKVYVEWDQSIFDDQEDDGGQVIYQLQGAPISASFQLQASATTTSFNLQAYYTNIATTSHPLGSVVDLGWVHDGNTVFVLSGVPGLLMNTINPPTNWMQLSLPTVGNKPLRQLVIPGSHDSGMSLIDGSTFFGDDADHVLTQTLSVGGQLANGARYFDLRPVISSGIFKTGHYSTLPVVGYQGANGESFSQIISEINAFTSVNAELIILNLSHDLNTDSGYGSLTQANWNQLFQQLSGLSHLYVAPNPTTIDLSTLPLSQFIGQGSAAVIVLVDAGDTTVTLGSYASRGFYNSTTQFPLFDSYANTNDLSTLENDQLTKLAQNRTSWNSSEFLLSWTLTQQPIDFTPKDAPSIIDYANQANNDLFTALPPVINRNVFPNILYIDNFNRTDVTALAIGINDYNTNWQAMDIQVQLFVSLGRRVTQKLRDAARFFQLPYKSFQDRRRKRTVEESFRVVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWX2</accession>
    <name>A0A2R6NWX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v7386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWX2"/>
    <dbReference type="STRING" id="98765.A0A2R6NWX2"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
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            <strain evidence="2 3">FBCC195</strain>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
    </evidence>
    <sequence length="1886" mass="203387" checksum="CB7BB4D2E1023635" modified="2018-06-20" version="1">MSVTDAEDHIHQVVEQPELQHHEDVQDTAVPDASTKHIFEPFAYEHSGSQHATSASEESTVDTAERVLDDINSKDDQDIHEDIGDIAAAQATYHSLPDENDTSEATATDNAAEIEDGTDALGASLEDDAKLEDLLVALESDASKPVSLETTDVDDAARKSETKPASEELVAPESSAPVLPESATAEEDHETSSAVTGADDRADLTEETATDPFADPVSPSGGESVIVSEDAPVRVADEAFVSPKHVQEDLAEEVQQESDTEARVDQVVEEVPAEDAEPEEGVTLSEPERTGHESTSDQEATLETTEFEGAPLEEAEPEKDAAFVADDIPKNEDAPAREAVDKPKQPEEALTEEDQPEEDVAPADKYKSEDVAAADEYKFEEDVAPTEEYKFEEEVSPADQYKSEEDAAAVDEYELEGDVAPTEEHKFEEDIAATGEYELEEDVAPTAGYKFEDDVAPSDQYKSEEDVATADEYKFEEEVAPTKEYKFEEEVAPTEEYQFEEEVAPTEEEVSPADQYKPEEDVAAADEYELEEDVAPTEEHRFEEEVSPADEYKSDEDIVAADEYKLEEDVVPTDEYKPEEDVAPTDESKPEEDVAAADEYQLEEDVVPADESKPEEDVVPTDEYNPEDVAPAEEDIPKHEEAPIEPELLREVPEEELPEEIEPAEESNPAREESLIQEAAIETEDSEEANEVDESSVLEDTSTVVEASQEVEPTDDVAVDTEGKQSGDAFVPSEDVNASAEEPDVEDAISQAHEIAEEPSAEDSQLTGMNFSAEPALESITRDHLILLSSSSETCIADADVAIDEPEVLSEDVVASAEDLDYADEVEEPQSEVSYSQVDSEDVSAYQATAGEADLEHEDLSENIIESEAPVVSEEPFTGTDGADGLEAQSLDVEASDLSSSIPEVVDELSTAEPPAVDEEVTEVISELIFSAAEPESKTVVEEEEITSPADVSETHEETAVPAPEESSINEDDEITPSIDDLRQEPEEIPLVLSAESNIPTSADVAEDVDVPLVDFSELSPPSEAPEGVPEDTAGPLNVEAVQEIEPPTEVAQEEVAAPVDILPLVEKPDDNSAIEVADLDVSSPAEHIEESSVPSVSAHFEEEPVETGPSADAYVNEEVNALEVEIPPIETTPDEGTESETPVGEDAPTIAVTDEDSGEPAHIPDLTPVVELEAERPRSPWTPSYSVITQGPGTESENVADDAEIAELDQLPPPIEKEVSETEVSLIDAVEADEEQDEVVATVSNGSEADHRTWPVSYSVSSQGASPLAATPLHFGEAPAVSVLSGEESVPDEEGGDAEAGEPGLSVEADAPEIVQDIPSVEHLVPNEDPEEINVGEPELAPESIASSVLEEIVPVEQFAPQVDVVEAKSSEPELEGEGDRPEVTEDILVPSSIVITSDETEEEPTISGFDTTDVDPLANEHEQNAAPERPWTPSYSVSRQGSSPLQTPKELEELEEPPSATLVDQSGERTAPERPWTPSYSVSRQGTISPAPDAAGIYDSEAFGKVSPTILSPEIVIAEEDIPAADATASESQATADRSDSGPLQTPRNDIAQLPESADSQPGRPWTPSYSVSRQGSSPMLESQVLTSESFEEATHDLVEEPVQTPVISIQDENEEPKSVLEEPSVNDSSSTDIPAQAHPQIVEASEKRPGSPWTPSYSVSRQGSPAASPALRPKEIEAEESQDEPAFETTEVTEVEERQPEIRVDAAAESGDKPERPWTPSYSVITQGPSSPSQDSDAVSNGKIERQAFPSMEIAENGPELIAKCVAVSLKLKCRTNFAQRRPSLARLAPLNEREQIHATSPAELDPTGLIAPRARIESTTSSRFFPGGWFSSASPKSPDDIRTSLDHASGEFSRIDDGSEVPVNTPIDGVDGEKRNKWCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXG0</accession>
    <name>A0A2R6NXG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXG0"/>
    <dbReference type="STRING" id="98765.A0A2R6NXG0"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="111"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="115"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="244" mass="28581" checksum="88DAD888DB4DFAE5" modified="2018-06-20" version="1">MDCQHEINWSMRQTLVDWMAQVHLRYHLLPETLWIAVNIVDRFLSKRVVSLVKLQLVGVTAMFIAAKYEEILAPSVEEFVFMTEKGYTREEILKGERIVLQTLEFKVSHYCSPYSWMRKISRADDYDVQTRTLSKFLTELTLLDHRFLRVKPSMVAAIGMYTARRMLGGNWGEAFVYYSGFTEEHLLPGHAMLVQKLVEVNPDRQCICKKYAHKKFLKASAFAVDWARRHYEEDGNMEGMVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXJ4</accession>
    <name>A0A2R6NXJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXJ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NXJ4"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="679" mass="72941" checksum="3AE6B1696C9D260F" modified="2018-06-20" version="1">MALCGLGTWRFPSTPPYILPPFLRIRRPKSTIKRRPSVYEDSSDIFDPEQELLGADGSLENDSDSAANHSLRTAPVFTGDAFNVLGPNILPQRALYGHLISQHVPNFPGQGKSRKVYINTNSPFSALVCGVQGSGKSHSTSVLLESCLISDERIGTLPAPLSALVFHFDTAAGGGTVQPCEAAYLASIDPARGGDILAPAVTVLVVPTYLKAMKKVYAGLPHVKVEPLMFSSKDISGERLLSMMKVEENAQIPLYMEAVMNILRSMEDNFDYELFRQKLSGPIFNDGQKAMLNLRLALLDSCLKRGDASNRVSNHFQKGQLTIIDLSSPYMDSASACGFFDMILGLFIEAPVETSGKVVVLDEAHKIVSLQTGQAIVFAPNGLGVRQTAPKHTRNGMVAPLGQGYLLVRSRFRVTRDGGHSILAVSDPDSTTRIRPVSGREDAGVASVAEASDGVSPPEASAKMSHAGGKSAMTSKSVHIAMPAAPHVKLSPTRPPVVSARSKPNVFKIATKVPAISGTGKVRPRAGLAAKAVVNTGAIKSSTPLIKPSANTNNRLSKTVVTNPKSVAANTSSSATSLKPQIVVPKASSSITGITSKTKLRRFAPLVRYLQTQEKLGRYEIYEKTVRARFREEPQICKLEHEAFIKLFNAAVSSDVVRRIEVEGSKPKITLSSRATLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXV0</accession>
    <name>A0A2R6NXV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXV0"/>
    <dbReference type="STRING" id="98765.A0A2R6NXV0"/>
    <dbReference type="OrthoDB" id="3193774at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015350407" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="14594" checksum="8C93AF7454E7E366" modified="2018-06-20" version="1">MKSLARLIVYLLSVPLVTVWPYTVPPGSPGFYHGNSTAAVTFDAHSLFLGDKRLYVFSGEVHTWRIPSGPALWRDVFEKMKVDALRLFPYLSLSTAGYRRLDSTPSQSIIIGVYQRESLVLLISTFIGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY76</accession>
    <name>A0A2R6NY76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000703">
        <property type="protein sequence ID" value="PSR79298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY76"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="5921" checksum="FE4205539FBF6CCF" modified="2018-06-20" version="1">MSISEYRHSILERKRMQDDRHTIACGAPIDTANWACLAGSMYPVHLSSGISQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY92</accession>
    <name>A0A2R6NY92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fms interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000680">
        <property type="protein sequence ID" value="PSR79877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY92"/>
    <dbReference type="STRING" id="98765.A0A2R6NY92"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22216" checksum="3D3546BFB619A2E9" modified="2018-06-20" version="1">MALLDSTNAALLPPSPDAVVDSLRELISSAYLNHDTTSIHIRAGALFARLKALNRSANSAARTHKQTTADARHEMDQTYLGLQNLLYEKRHLEREIEKCRQFASTYQDISLYGPEEYMERAPEEMRTEEILNNEHSLMLNRLSFELQERQRLDRIQKESLRQKEELLKESKAKAAVMDNVKTQIDGLMKVMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYJ3</accession>
    <name>A0A2R6NYJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYJ3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7198" checksum="9C5381A6CE6D6E6B" modified="2018-06-20" version="1">MSENKSSSSDVQVSAKIIKRLSNCIGPEDWKIEFGTGKAPSSFRRPLRGGQFKCEISRLQALKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYY0</accession>
    <name>A0A2R6NYY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000640">
        <property type="protein sequence ID" value="PSR80800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYY0"/>
    <dbReference type="STRING" id="98765.A0A2R6NYY0"/>
    <dbReference type="OrthoDB" id="2796873at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="605" mass="68932" checksum="6C7A3C7C932D4C52" modified="2018-06-20" version="1">MKNIVNPLVEAGKVGVEMTCADGWVRRVFPIVAAYVADFPEQCLVANVRESYCPRGLITPENRGEPSGCLLRSVSESLSILDKHQRGEDPPEFHERGMRPVYEPFWRDLPNCDIFACMTPDIMHQLHKGVFKDHLVSWCTKLIGDSEMDRRFMAITEVPGLRHFKKGISHVSQWTNSERKEMQKVFVALLSGAVSAEVLKVVQAVIDFIYIAQFQQQTTQTLAALRTAYDTFHRHKDVFISLHVHEHFNIPKVHAMFHYFEAIEKKGALDGYNTKLAERLHIDFAKEGYRAGNHRDYIANMTKWLQRQEAANLRKDYLDWLHQEEAAAASLKKKVGSCVDGPEGDESDNEENTIDKRQDLRFLPSKNPRLYRIAIKCPFPRMALGVLEQAHGACKFLPALTAFLKLHFPQTTSSLPTRLTRYHIYKQLKMEQPWNRYVASSVSFDKIRATAAVPAHGRSWFVPQHLDTAIIIEDPSVYNTKLKGSLNGLRVGRVRVIFELPAEYDCLSHPLAYVEWFTPFGRVENNTRMLQVSRSTRNRKQNADVVTVDRILGACHLVGKTGLEIDRSWGSENVLETATVFFVNPYLTIDCFSGSGLYHLPLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ54</accession>
    <name>A0A2R6NZ54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v6555</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000629">
        <property type="protein sequence ID" value="PSR81024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NZ54"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="13">
        <location>
            <begin position="1389"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="2048"/>
            <end position="2376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR81024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2437" mass="274275" checksum="76E62DE44ECC36B4" modified="2018-06-20" version="1">MSLPIRNDLREPPPTFAKLDHESPLHLLEEIKLASGALKDGLTVKLSDESTRKEYVKFVKTLSEHVICSFYPPHEYSWTAIHEKIKLTEATCEVIGLVGTAFCSEPDFVDVAKVLFCRLFDVCRVLDTWVDVPDVPVEDGYPTPEELRQKTEDACIGLLRAWGEDVSDVYAWKVLKEIAMEYMALCDELLDHSAIAAGPLRLRLFTLPRIYPGEIFGTDDVSGSEMKIEDSSQLPLVMTSIAKILMEALRPPLLAQWFLADVFRRSVELSHRIFNFIVSPLCITTDPKRVRSIIRIVVAVTSSLQAQPRFEGMVESMRFHLLLRMLHDGPNDSWDDVYVALHEVYKIRLSVPPARTDVESVLAALGAEQWGDKGHNLRLVASFYLLIAMPSLDMEYLREIKAALLQKNGMGVYINVLKVVEDRLTASDAHLVPDDHDVLQTMASRKGIRSMVQAIIQPDELSWMEDDDSMNDSQYISRAVLEIGSRYQRPIYNSSAEGRVLLARHLTRLPCTLAGHPDCPCPATPTRIAIPLVSTCIQVLTCLLNGPEMEVTAVVRKTGYDALAQTIRHQTADPIIPVVEHAAQLAARGMKDAERIVRLSAGRCLAELVRLFQDQGADSDQRIEQIFHMIAMILNGSEARFKETVLITAGTIAKYASHEVLWRALRCLIEQLGSGNPVLKGTAYMQIRTLAKQSKSPYTFLSPFMDRISVLLVSRICTQPSALQECCLLLSVTPASFILATVVDTLPHLFATQNRRALHEVAKEVNKTPHQLFFDYESKILARAFMLPKPGETTKVLNFIVAILKEVIGNEGSVEASGLVDGCLVNLVSDLVIEMGREDEDVARSATQALMKVGQIAKPTRTMSPLEGMTGFLQPHILGIMAHINDELQFKHTIEQKRQICRSLGAFIREMGPVMSSIAPQIMAALQTTVAVPELAEVTLESWDSFLRVLDLQDIGPYIGQTSASFVSFWPIFSAPARNIARGCLEYIIADKGDEFGVFLDEVVDLSPISELSDIHQRLAALRTEWTLSERLQKLLERSNTDSITVTVQALSELKHFMLSHENFVGEMASGDTFDPFIGRILSVLLSAACRDGEDAEALRMLAFDCIGILGAVDPDRLELVVNDPRMIVTNNFADETEAMTFVSHLIKDVLVGVFRSTSDIQYQRDLAYAIQELLKFCKFTKSLLTTPGSGGSVPIKVRNRWNELPKHVIETVTPLLDSKYKLHTGEPEDIQGPIYLTKPTYREWIQSWTSSLITEASGPKAKAIFSVFPRVVKNKDVGVARHLLPHLALNILVSGSEKSAENIRLELLAVLEDQVDPSSTSTHDKKELSAQTTFMVMDHLNKWVRTVRHDLSSKKSESKRGRANQINSDTEEQLLRVDSILSSIDRNLMAQAALQCKAYARALMSFEQQILAVQARDPQKEELPTYYERLHEIYAHLDEPDGMEGVSTLILSPSIEHQIRQHESTGRWTAAQSCWEVQLQHSPNDIKSHLGLLKCLRNLGHYDTMRTHVDGALTRNPEWEPELIGYRVESGCMIGDWDQVQSWVQQATADDSPVLLARVLLAMRSEDEQAISVALTAARKSLGAPVTAAGTSGYRRSYEAILDLHLLHELDTIYRSTITLASSGSLRRRLENLQQRLSVRLNSTLPSFRIREPILSIRRSAFGLRTSENRRFKEAIGQSWLLSAKLARKAGYWHTAYSALLQARQSDAPFTYLESAKIVRARGEPLRALQELENSLHASKLEKVSEVIDITGESEAEAAEKTRMRAKTIALRARWMKDSDRYEDRYVVKIFQEASEILKGWESGFFHFGQFEDECSKDVKQADYLSQGLKMNLITIRCFIRAIRYGTKYIYQTVPRMLTLWLDMGENERTASHDHFKKINFEISKTVKGVPMYKWYTAFPQIVSRVGHDNPEVYTVLSSLIVYVIQEHPQQGLWLFAAVVNSQKDARSKRGRSILDKLRGAGDGNMNKLISASVSMAAELLNLCNGQLGDKSSVNMSKDFPRLFKLAPSPLIIPLQQSLTATLPPLSSTQVEDHKPFPVELPTFYKFSDEIEIMKSLAKPRKICIQGSDGHFYLFLGKPKDDLRKDARLMDFNSVINKLLKSNSESRRRQLRIRTYGVVTLNEECGFIQWVHNTVPVRSILIKSYDARGIKSWNAQMGSIFGRIKQSPDKDAANLFVHEILPMFPPVLHEWFIEMFPEPSAWLAGRLTYSRTVAVMSMIGAILGLGDRHCENILLDMNSGDVVHVDFNCLFDKVRNSSRVFENFLLIYLQGRQLETPERVPFRLTQNMTDGLGVIGVEGVFRTACEITIQLLRDNRDCLMSVLDSFVHDPLVEWEEEHMKEQRRRVRNSFLPHEPEDRATVQQQASSSSRKFDANVLPDTVNLRNLAKNALGIIGKKLKGIYTVNRTAAKEKELSTSGFVQILIQQATDEAFLVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ82</accession>
    <name>A0A2R6NZ82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ82"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ82"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44637" checksum="9B40F75D597608C1" modified="2018-06-20" version="1">MPATAFQIQVAPHAPTSVATVTLPPLHILPSDLRPRCRAEERIFQWRGVNSPPPSVLPIPIIQRMASLASHASLSDTTAYGSGLRKFHLFCDIFSVSESDRLPAPFAVLHSFAIWAAADPDINDPTMAGTTPFEPVAVSTVRKYLSAVRAWHIAQGWPAPLSADDHSRINWSLRGLDRMQQGRRSKLPRPPITLPMLAALRRTLDISNPFDACIWAMACCSFWGMMRFGEVSVKSRNEFNSIRHITRAHVLFGHDLDGWPYARLDLPAAKTARPGETQSVFLSQQGETCPLEALRNLSQVVPAGPQDPLFSWRDRQGDLRPMVRDTAMHRINAVLHAWGWGTSFGHSFRIGGASFFLGQGVAPEVVRIAGRWKSLAYEVYIRAFEQVSSHHLGNLSQRYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZD1</accession>
    <name>A0A2R6NZD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZD1"/>
    <dbReference type="STRING" id="98765.A0A2R6NZD1"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="277" mass="30038" checksum="C780FEDE9AB2ED80" modified="2018-06-20" version="1">MLTALSSDYVFDGSSPPYPPSTATNPLNLYGRTKRDGEVAVLSVTGAKTVALRVPVLYGPTPTPSDSAVNILLDVVSDQSGKTYKMDHFATRYPTNIVDIADFLVRLSTLPPSKTLPPIIHYSAEEPFTKYEMCLVFAKLLGLPHTHIIPQAEEPTDPNASTRPRDAHLYTLETEDLMAGYGGLGWTPFEEWWKSNKISQTRRPSGTSTGIRQDTWNDSCDMNGPGALGYALVLVYASYTIPGVEAVYASGKATKKVGSAVPLGARHLDLIATMDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZX9</accession>
    <name>A0A2R6NZX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZX9"/>
    <dbReference type="OrthoDB" id="3266974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="478" mass="53645" checksum="1D4C7B0653C0D2E5" modified="2018-06-20" version="1">MVYKLDHITFALQADNGEQPVKNISLGFLWVSFTPDIYKKKQDQVRSIYTGNDDPAFDPSRPCNIPFVRLTTDGILQARPSVEGSYKLGVHDDYARHLIVFWAAQTGDIAHVAAALALDPLMDVAIIYDPTMESQANTAYDTYLNAVVSGQVGSERDYEKLGVGEGRLRMIKKTETKPIYYGLCPVDETGTYPIGEIGISRWRSLGKDVQELFKETTLWAYKNGYGARLEYPTVSVVGATQLIANVYKEYKASWKAREFYEFMGGALSAKSLAQTEIDAWVSKKFGKKKTRKLLLLWSRYSGQNPPGGYNPAGDSDPIGQQQIIDFSRKLDFTVITVGHDCTWSKIPNPHGDVHFGEFWIEDPFDGHGRPGQTSLYCNLIKNYNIVQIGQKTGGMDNAALVGVPTVYVEDVQSPSLARMQKWKEMRRYKGAIVSQPPTALGKQIRGCYPAVPGYQKQDLEIIEKALKAMWTDVYEPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P002</accession>
    <name>A0A2R6P002_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P002"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="37"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR81771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113105" checksum="9E52C4D9F6CEC835" modified="2018-06-20" version="1">MATMLPSGRNTRRTEKEGEGLEDAVRSLISAIGPKGWPAMAKTLRDVDQDKIGDCKEDMDALFVFAGLFAAVLTPFLIETYKTLSEDPNDTSVSILRQISSQTRSYTMHAGFLNSTADPENIPAFTLPLLALPINIIWFASLALAVVTASFAILAKQWLREYMSVESTSAQAHLRIRQFRVTALDDWMIFDIAAVLPLLLQLSLGLFFLGLCFFSWTVHPAIGYTIIPIVFGWGILFAFAIIAPALSARCPYKTPRFKRGMRTLRAWVCSHEILRSKLYCGPVHDDGTPVEEEDAVADDKNDVQILTDADTILLDDDLLGTTMLDSLQDTSAEPAKIMDFVVNALRQHLPESNSRMKPIQLLDLSRLPGRVCTFFVGITAQTLIQRIKSEHPIGELEEWMQNAMTILLLFSPRSNFSNTEAHDALTHASAVPTFQTLKTHIFGRLDVARLTLHALYTAIFAQHAEDRCDESCTPESPCITISRLAKQLRLDPQLDFKQLPRAFIGTILRGCLGPCLLHKHSDRRMPFAVQVDLVIATDAVCKDDELLTECTQSLLATDCDPDPTNIIRLSLALLGHRMDPMNNIPLAGLQTCLQLRSQPRLTAVAFGAVIEVVSQTLVRRLESRQGEKWDEWVKDAIIILFSFYDFPLPQIAEEAVQLCMKISLKETCHIVAPEDFPQILAHISQRIPVGGPAVSFDSLLQIPESCSLPATSRNILLDAMTNLLTSLLEPGNDGMDRSGWIIAVIISISDFPMPQNATTALQLYVEKYTMNGTVKVLGSRIKSREAWQALSHILQRLRNSFFQLDMKDVLESIYTLVWENLRLCGLPTCAYNSPDLRELLLPYIKSLPGDIVSILTEHIDRAFDVDPPLEPGVHKSVSSEMHIYSIIVVDRIKDDDIFLQVYLQKVLQQYRDMPVECSKFILGAIRNRYDVGMPLDRLTCVLHLPDISKEAWTAIMDGTATILEPALNSHGQAGAWRDWDAWMKGALLVLLSTSEHIMSASGKRPQASNATKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P034</accession>
    <name>A0A2R6P034_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR81993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P034"/>
    <dbReference type="OrthoDB" id="2576082at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="180" mass="19835" checksum="595547E2C68409B6" modified="2018-06-20" version="1">MDNESESGLKFTLNCDTTVNVQRNTGNNYSTVSLVVHPVPSTSPIITYTGEWLDSEEEDNYWSSYMNGTFHSTQDYGATATLRFNGSAVYIFGSRRPDRGEYAVDLDGLTTTASGYSNNLTFNVTLFSATDLDDTEHQVALKNMFSSPAAAWVDLNYVVVTSGDGNPQYVLFAFPVQTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P077</accession>
    <name>A0A2R6P077_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v6127</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000600">
        <property type="protein sequence ID" value="PSR82057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P077"/>
    <dbReference type="STRING" id="98765.A0A2R6P077"/>
    <dbReference type="OrthoDB" id="3205891at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="449"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR82057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="695" mass="78202" checksum="0E20A6ECA1028A53" modified="2018-06-20" version="1">MFNALRKHIGSICHVYLDDVVIWSQSLEEHRRNVETVLQCLRENKLYCSPKKTDLFCLSIHFLGHYISARGIEADGAKVAKILDWPVPRCASDVWSFLGLVRYISNFLPALARHTSVLNSLTTKDAEKDFQWTNAHFMAFEAVKTLVTSRECLTVIDHNNIGNNRIFVSCDASDFCSGAVLTYSESPETARPVAFESQQFSGAELNYPVHKKELLAIVRALRKWRMDLLGVPFTVFSDHRILENFAEQKHLSRRQARWQEFLSQYDYKIVYLAGKDNAPADAMSRKPPPSQGTTAAISSLRVQGDAEWLSAVKSGYTDDAWCTRLIDSLWDAVARSAIGADAAGVSAIDALSRGWLDNRDRYGISVRAGLLHIGDRLVIPRVPKLREDVFALAHNALRHWGNEKSYAAIRASYYWPNMRKELETLYVPACEACQRNKSSTNLPTGPLHPLPVPDARGNSIAMDFVGPLPDDEGFNCILTITDRLGADLRIIPCRTDISAKDLAALFFREWYCKNGLPLDIVSDRDKLFMSKFWKALHCLTGVRLKMSTAFHPETDGSSERSNRTIIQALRYHVERNQKGWVRALPLVRFNHMSTVNASTGFTPFQLLFGRHPRVIPPLVTVETDTPAESFDAAHFLKRLDADVMEAQDNLLLAKTNQAYHADKSRNSEHVYQVGDKVFCPPSIAVVNSCNEATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0E9</accession>
    <name>A0A2R6P0E9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v6353</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6P0E9"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="648"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1119"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1149"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1227"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1265"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1300"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1390"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="370"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="472"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1141"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="77"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="179"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="284"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1441"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1441"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSR81587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1466" mass="158626" checksum="43E9E2E6A1A29319" modified="2018-06-20" version="1">MFNNGEDDINNQHAGSNPDIPFIQVITDNASTPQVNNVHENPFDKPAELSGTSRYLFEQSRSPNDLLAPSSILRTPRASLDVPNSPSGSSWSSDGSTHVPPSPTLSTRSSVHFAQPSTLALRDNNPSERSGITSLGLLSPSSSSHRRKSSNASSFDGSQEGTEPDSHSIAMQTLHIPSPTQTQFDTSSVGGTTVHDRSLSRSYSRKELMSGDEGENHEEGETSHPALDLTQDTDIDAGPFAFKPYRLASLVDPKNFEELKEMGGVKGLLKGLGTHRKRGLSDRAFEHSKEGQEHPRTAEAVPSDDGRPGGTAGVGDGASQRHDPLPTGTKAEAVPGIVVTGDNGEAGEAEMAEGEGEEEEKRGGAYDAPIEERRRVFGDNVLPSRKTKSLLQLMWLALKDKVLVLLSIAAVVSLALGFFQDFGTPRPAGEPPVDWVEGVAIIVAIVIVVMVGSLNDWQKERQFQSLNDKKEERGVKVIRGGVETVVDVHQVVVGDVALLEPGEIIPCDGVFLSGHNVKCDESGATGESDAIRKVSYEECLKAHEKDQEPAHTDCFMISGSKVLEGYGSYVVIAVGTKSFNGRIMMALRGDTENTPLQSKLNDLAELIAKLGSAAGLILFSALMIRFFVQLGQNEPVRTANQKGIAFVQILIISVTLVVVAVPEGLPLAVTLALAFATKRMTKEKLLVRVLGSCETMANASVVCTDKTGTLTQNEMSVVAGSIGINCKFVHRLEDNRARTNAGEEAGVKPSVERKHYEDFSIDQTELNSVVSEPLRDLFNAAITINSTAFEDRSEAGELVFVGSKTETALLNFAKQNGWADYKATREAANVVQMLPFSSERKAMGVVVRLPGHKWRLYLKGASEILSKKCTSHVVVSKPGGGSQGANELETREIDELASDNISRTIIFYANQTLRTIALCYRDFDTWPPKGAQLAAEDEVSYDDLAQDLTLIAITGIEDPLRPSVREAVADCHKAGVTVKMCTGDNVLTARSIALQCGIYTAGGIIMEGPIFRQLSDTEMLEVVPRLQVLARSSPEDKKILVEKLRSLGEIVGVTGDGTNDGPALKTADVGFSMGIAGTEVAKEASDIILMDDNFSSIVKAIMWGRCVNDAVKKFLQFQISTNITAVIITFVSAVASVQEQSVLSAVQLLWINIIMDTFAALALATDPASPALLDRKPEKKNGPLFTVDMYKQIFGQSAYQTTITLIFHFLGNRILGINDSGDSNDKRVQTVVFNIFVFAQVFNSINSRRLDRKLNIFEGITKNYYFMGITLLEIAVQVLIVFVGGAAFQVSSITGREWGISLALGFVSIPLGALIRFIPNERLGRFFIKIRLMRNPEVLPITRPEAEWNTAIDLVRDNLGTFAHVRGARMRASSYVGKSRKAHAEPAQRVALSSIMTMVPTLVATSIGAGWAPHSPSGLSDPAHFDPSKSSAALWEGKIQIHPDTKPDDPAYQKWGSVSKATNTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0S1</accession>
    <name>A0A2R6P0S1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0S1"/>
    <dbReference type="STRING" id="98765.A0A2R6P0S1"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25144" checksum="3B654883159653A5" modified="2018-06-20" version="1">MAGYFSNHSQSRFLANLNTANTAGSQSPTTQTQNPPTTPGRLRAPSSRHFSTSLSGSSGDEKSQNKQKGPGTGTSNGSSVVHPLRNTYVRVRRPVWEDPLNITGGKWIIRLRKGVADRLWEDLVLAIIGDQFADCEQDSGGNESGTREHSEWPEICGCTISVRQNEDIISLWNKVDADPKVKEKINQTIRRVLNLPATTTMEYKSNNDSMQDKSSFRVPAATERTPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0V8</accession>
    <name>A0A2R6P0V8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0V8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015352343" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10671" checksum="E112208B40E636BA" modified="2018-06-20" version="1">MATMRPWTQTATIILFRRARCTLASPLPAQAASINQKNGLQLEWKSVGPRVASTASTTARQPDPQLNFCHVRSTTRPAALPETPPKVKSGNEGFATRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1C5</accession>
    <name>A0A2R6P1C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000564">
        <property type="protein sequence ID" value="PSR83225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1C5"/>
    <dbReference type="STRING" id="98765.A0A2R6P1C5"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="128" mass="14487" checksum="E6F39647D65B22E3" modified="2018-06-20" version="1" fragment="single">TSELSRRIKDAERDVKRLVTEEYLETPASPTHHNGHHRNGTDTEAQLRREGITQDAGSDDDTEDEDEDLQSVDALEDRFIALEEEVATLVADVHDLALYTKLNITGFMKILKVRFLLLTVNHTLTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1X7</accession>
    <name>A0A2R6P1X7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000551">
        <property type="protein sequence ID" value="PSR83811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1X7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1X7"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR RGLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="280"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR83811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="409" mass="44780" checksum="1C566313CE9705FD" modified="2018-06-20" version="1">MSQLNAYYDEQSYLSSHDTSSFDMTMVLDAKPLFYPSENYLTGDYHNRLVHPMDQSMPAAHSFPYDDSRHSFCPAPYPTNSITIYDVHRRNDIRHPTPVRPISPTQLYSSGGWIDSGSEAYRAEPSAHLSSSMPSQPSVFVSPPTGSSSLQSVSPIPPQPHNPPPPSWAMSGSLDPATGVYQTAPEHPRVRTAQACDKCRGRKAKCSGEHPICQRCRLRGLKCEYASERKMRGPNKVKRKGGVNDVKSNRRMSVASLSSCSSEEPSTSPRQRRSPKSPFTTAPRSMSTSSTSSDILPPSLSPSRLSSGSSSSTQSPRLGVEAYDVSASPRADKPRPPPLDLSGISLYEQMLPPPMVQPQMTSYSNETSTFHRRASLPSYLLGAYTHRDVSEGQSACIPVQAPEALEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Z4</accession>
    <name>A0A2R6P1Z4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alternative oxidase</fullName>
            <ecNumber evidence="13">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v5600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="13"/>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Z4"/>
    <dbReference type="STRING" id="98765.A0A2R6P1Z4"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR83891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="316" mass="36136" checksum="E61141504744CA91" modified="2018-06-20" version="1">MPQLFRALKAFTGVSLGYYHIYYLLTILQEDTSPPSDALLTKADVVSVIPAIVKGDWVLFHPVYSPEELRAVEVRHREAKTLGDKAASTAVLLARKCFDIISGYKHKPIPPNSKMTIEELRKGGYILDEKQWLARILFLESIAGVPGMVAATLRHLRSLRLMKRDAGWIHTLLEEAENERMHLMTFMTIRKPSIFFRILVLGAQGVFYNAFYFEAGHLPAWKDMPAPEIAKDYWRLNDDAKLLDVIYAVRSDESTHRFVNHSLANLNYKTDINPFALREPDMHVKGTKLGFDRDEAEEYVRASHKLIDKGRETGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P262</accession>
    <name>A0A2R6P262_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000544">
        <property type="protein sequence ID" value="PSR84041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P262"/>
    <dbReference type="STRING" id="98765.A0A2R6P262"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR84041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="180" mass="19905" checksum="2312A42C00B68331" modified="2018-06-20" version="1" fragment="single">MSPSPQSTAPPSFEAAIFSSGKHPSPATPTEEITVEAKAKSFDDSSEKTAVSTTSSAKASPSPSIHEVDTEKAERSLADDDKALAQYLVPTLPKGVKTARKKPASLWIRFRVWYNPYRMLFTFVFTLNMVGIFLACIHHFPYAEHHGAALALGNIVSAVACRNELFLRYLFWVIVKVFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC08</accession>
    <name>A0A2R6PC08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC08"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9552" checksum="089B1F6818CD0DA3" modified="2018-06-20" version="1">MCGADFVVLNGLWRWSSELVGYLSVVCECKMGREDPQEYLWRRVVAAALSKNEDRSAVVYICQVYTVYQSRPQEARGPTSDGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC55</accession>
    <name>A0A2R6PC55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v5104</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC55"/>
    <dbReference type="STRING" id="98765.A0A2R6PC55"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR88753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="309" mass="33757" checksum="7C6F6DB25CDD61AF" modified="2018-06-20" version="1">MGGVAMSPLPATVPVLLSTAIGTALCAASANALNQIQEVPFDAQMTRTRMRPLVRKAISPVHATTFALATGAAGPVILWTMVNPTTALLGAANIVLYAGVYTWLKRTSIWNTWVGAIVGGLPPLMGWTACGGHLFPSPAHPIEPFLPSFLSTTSVVDPSLIDNPLAPLALFMFLFSWQFPHFNSLSYFVRGSYAQGGYKMLSVLSPSKNALVSLRHSLLQIPICSILVPLSGLTTWAFAITSLIPNMVCVQAAWLFWKYGGEQRARLVFQHSLWYLPVLLGLMMFHKQGMDWMSWMGLRRDSIEEEGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC95</accession>
    <name>A0A2R6PC95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">R3H domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v5005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC95"/>
    <dbReference type="STRING" id="98765.A0A2R6PC95"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="319"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR88856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="57996" checksum="39CAFD38E938B69B" modified="2018-06-20" version="1">MTSTSSTPDISSLSLSSKPSQQRLHDTYDYEGTGSGNGRNPYHFSTSPPIPVQSQYNPLGISQSPLKNKTMRGGLPSQWLENMGSIADNRSLSPNNNSDLSSSGDSPTMGHILTPGLAPGTPSQGLDEEIIPTAIVIKNIPFNVKRETLLDIIASLSIPTPYAFNYHLDQSGQFRGLAFANFRQSVDADAVVAALNGFDVQGRKLRVEYKKVLQAGEKERIEREKAIRRMRSMQLEKEQAAMQHQHQPYDDFGPVIAPPFTPSRSFSGASPFPSQAQYSPPPVPALPTPNPYNLSTSPLPPSTPGSAMKTPSTELDLNDPSTLEIYSRILLFKDDRMRDELAFSRTLTPKQRRVVHLVAQKLGVFHYSIGEGDERYAVVTRFDPAAQQQSAGGRQTLSRAPSSYLSAGSQVATSLRMKKSMPDMKTLQTQAPRLTSRASNGNIREGYATIASPSRRSPGGFAALFGNAAFGNAIPPVPSLPSSVTGMVNGGLDSGVVRQPRGPGIGGFESRRERRESQSQRSGFEARSHEPLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG40</accession>
    <name>A0A2R6PG40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG40"/>
    <dbReference type="STRING" id="98765.A0A2R6PG40"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR90673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="218" mass="23326" checksum="DF298536F01DA673" modified="2018-06-20" version="1">MVTDLVESSLDGQALDTLLFGGAPAPDQLPKKAKEAFPNTVLSQAYGMTETNSIAVGIAGEDYEARPNSAGLPCPVNDVLIVKDGKVVPPGEVGEIWLRGPDVMQEYWGDPEATAKAISRDGWIATGDIGNIDEEGFLYVRDRIKDLIIRGGENIASVTVENALYHDERLAEVAAVGVPHEKLGEIVAAIVSTKPAFHGKVKETELMEIARARHAPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG88</accession>
    <name>A0A2R6PG88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000492">
        <property type="protein sequence ID" value="PSR90759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG88"/>
    <dbReference type="STRING" id="98765.A0A2R6PG88"/>
    <dbReference type="OrthoDB" id="2753193at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="368" mass="42576" checksum="C98D85CC1985F0A8" modified="2018-06-20" version="1">MDEAIKDQCKQLYSRIKAWAKNAGVHISPKIAQAAKESRCINYTLPLDDDNGCSAPDDQDIDADSDDEEPLPTNGKRSRPAKDSVRPKKHCPLWREVSGIEIMLPSSCVEAVRKHACMQVLVETEYKIRVGQANDGLNSVRTHLITSHAFDRFKTNLNGQAAVTRQRARIMKKHGYIRRGASCYRRAYRALLSLGLPSGNSMGFKVLLWGDVKAFTVNTGAQQLGDSRERPSWIWENLPFFDNEHLEDNVKEYSQDAVRVHWFRVNAVKDRWSEEAALLEEEMRRTVRFFRFQHHQWLDRSRRREREGEHGHAAYAKKHAHRYERLLQECTKRFSDFVDMAFDYQGETWKRSAVTKAYEIDITLPGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN30</accession>
    <name>A0A2R6PN30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN30"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR93727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9455" checksum="EE311C3280BB720C" modified="2018-06-20" version="1">MSEEKRIHLPSGRPRLCPRYNGVTVMRHAAPCQPWIGITGDPGTQRTDTYHTQKCNERVLNLVEPATTVFLAARDSPRDPQADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVE1</accession>
    <name>A0A2R6PVE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVE1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="15541" checksum="8268509A987DFB43" modified="2018-06-20" version="1">MHKLDADPDTLTWHLADQTSNRLLCWDKHKECMGITMWMPVGSLNKEYFVVSAKSPLETSQVVYRALKLLSTLVDEHAAPYGVLTDEVVSVVMERDSIADKRAMQVWAYSRVETTVARIQQETCVMCMKCLSWTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVS4</accession>
    <name>A0A2R6PVS4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000430">
        <property type="protein sequence ID" value="PSR97725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVS4"/>
    <dbReference type="STRING" id="98765.A0A2R6PVS4"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR97725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="315" mass="35173" checksum="5F87FA9ED00BE573" modified="2018-06-20" version="1">MSPVSDNFFWKYLQGRGYMVLEKQGDQEISGSIDGIYGRPYFYRGIIPKAQKTGKKPAAAPFGASKTTKTAKNPLFESRPKNFGIGQDIQPKTDLTRFVKWPEYVRLQRQKVILNQRLKVPPAIAQFTHTLDKNTATQLFKLLNKYRPETKQEKKARLEAVAKATAEEKEAQAKDSKKPLFVKYGLNHCVALVEAKKASLVVIAHDVDPIELVIFLPALCRKMGVPYVIVKGKARLGTVVHKKTAAVVTLQDVKSEDQRELATLVSAAKANFSDKYDEQRRQWGGGIRGNKSAQMMRKRAKALGQTLSVASAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ46</accession>
    <name>A0A2R6PZ46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000420">
        <property type="protein sequence ID" value="PSR99324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ46"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="8987" checksum="C427F3996D53D858" modified="2018-06-20" version="1">MPDESVATSDEMEAYNLEDIAWSNVVPLGPSAIQELACIAILNTAENERDRYLSVPQIHCTELERAQLGPRMGKHPKTHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5E9</accession>
    <name>A0A2R6Q5E9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000398">
        <property type="protein sequence ID" value="PSS02342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5E9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="24591" checksum="866377ADD129E239" modified="2018-06-20" version="1">MLPVGDLLSGLEQIGESIISALPSDVADPVEGLLSEVLGATAAVSDDSLATADTDPLATAIATLDPLATDSISVDPLATDTAVGDTFTASSTVDPLAIATIYVYESSADDTLLSVNLASATVADALPTAPPTRRGLLDGILDGNGAGIASVADGLLSALPSELAAPAASVLNKFLDGTSSAQPKPSVTSNPSDNSGSAPAGNSSGSSSASTSSSTASATNNAALGSHVGFPQISLAGIATVVCSMFLGSFVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEZ6</accession>
    <name>A0A2R6QEZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v3490</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="MLYV02000343">
        <property type="protein sequence ID" value="PSS07207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEZ6"/>
    <dbReference type="STRING" id="98765.A0A2R6QEZ6"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSS07207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="19444" checksum="6B104E9FB28AC8B6" modified="2018-06-20" version="1">MAKIEEVPESPRPKAGKTKTKQTSTVLKYYLVAYNLVSALGWLYVLVGTLVHLFNLDAPSSPFSAKLASVPFLSKAATFLNFSRTAYIEKRLPASLGFLVPVIRRATTTFDRVGWQTTMVQTLAIMEVVHSLLGWVRSPLVTVAMQVASRYYIVWGITSLFKSVCPVLAIGGWTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUG8</accession>
    <name>A0A2R6QUG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000315">
        <property type="protein sequence ID" value="PSS14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUG8"/>
    <dbReference type="STRING" id="98765.A0A2R6QUG8"/>
    <dbReference type="OrthoDB" id="3009656at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="311" mass="34931" checksum="F5729D56706B41AB" modified="2018-06-20" version="1" fragment="single">LPESMPRSRMLPQDVPEFVFPYTTISPSKSTHNAETRFTYTASPFRFSMHRIFTREVLFSTASYPHHIQTPVSSRQNGLANIYGLGKHTESKLYGNHPIYFEHRTTGTHGVFLMHSNGMDIKINDTDGTSLAYNVIGGVLGFDFLAGSTSILEKLLGNYLGVVGVIANYSAANIPLETIWTDIDVTVIPGEQSSDTKLRRISPSVCSIQSLVPSSQTWITAAQSAVGRRSLQPLFKVPLVALKWNSDWCNHDISPLYNRVLVTHLQVYEIALPFNPQWIFSHQSKSRHRQKHKDINVDEKEVLRVCMAVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R770</accession>
    <name>A0A2R6R770_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000272">
        <property type="protein sequence ID" value="PSS22623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R770"/>
    <dbReference type="STRING" id="98765.A0A2R6R770"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="2">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS22623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="602" mass="67442" checksum="2EE1B853F19C7F35" modified="2018-06-20" version="1">MAPTVPPKSVSTKERDRDTQMPRKKPPSTPNPAAAVGILRALDPHADVHSLHREHSDDNTTELSSREEKRERKGFWERALERDKDKERDREKDKHREKERKDEDAQAELTRMIGYLTATASEDWSLVLEVCERASSSEASAKEAMKALRREFKYAEPSAQLSAARPTIPINTCSTDGAVSAGKDTHGFRGLWRKVKSPEKPDEVGLLSHWIWVKTFDNIAQGIPFDTEDAMFNPPVAAFQPPVTTEPSPPAAPKRPEFYTRCLNSQEIIYVQIPWASAGAERSRQLSHRPPRQKRTRSNDPNQPQIVLPLGQTDPTESTIEEQLLASLLVANEELTAALRQYEDLKRVGEERETQERSKKETRMDRNQMYYDADGPVHLEPPQFSYGGATSSHTPSPSSTPSQSPAPSVMVTVHPSLTHPLPTLPLPPSSISTNSHHHSIPSLAPPPPAPHGPRLPSHAVARSRTPSPDRSSLATSMTNSHQIHRGFSPEIGLHQSVSKLRVNDEESPDYSEEEYPAPIKPSAKALGKRRVINTEENDSIFDPDEMFYEHANESRRSVDLLSDDSEENQQRPVHYVYDAAAERLQQRLKEIPPPTPFTGVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R799</accession>
    <name>A0A2R6R799_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R799"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS22645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7648" checksum="C1EA549DDE9936F4" modified="2018-06-20" version="1">MFRICSFEDPLYLRSHRLAGAAVYLSRLQADRQMPRCVSTTTCRIREFKVPNPDYSTRPPRQKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7D8</accession>
    <name>A0A2R6R7D8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000268">
        <property type="protein sequence ID" value="PSS22685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7D8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="12068" checksum="D9E7B12B4C2D3F7E" modified="2018-06-20" version="1">MEEREEQEEKKEQADDLEEEEEDGGEKEGEEEQEEKEKGERKGSMETHIEVGEILMKIYDCGFMSLIETFHCTHVRSSPVNSHQVGLPGDLGFNEAVRPVVIRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHX2</accession>
    <name>A0A2R6RHX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHX2"/>
    <dbReference type="OrthoDB" id="3269398at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="668" mass="72612" checksum="5E39864EE6F39D67" modified="2018-06-20" version="1">MNSNTPIRRPRNWEVLQALESIDPPSPSPSYGSDFLASLSSMGEIPIILDPGICEGQEDDLQDSLHNVYRPVLMPTSLSNGTVGTFGPRRPLSNGCGIFVNTQGYRDSTGTLPPSPITPTRYSQFLAPSLSTSNNHKRTTDNSLLEASAYLSRSSIHISSPPAVTPGILATPSHSSEISSAASVSTPRSPNFGFDPYPSFLDDSVSTIAFAPGGSGLASPSARIELNTEAQDYALKHRWSQYRDKSLPPSTYSHSEQQFSGSLTSANRSPSPIRVVFSSNVHGVREGPLPGTRSTKSSGSCQSIRSVHSTSSGQTAHGPLPFPELSYSVPNLPGVLSWLANLVLELWIDQEGFRLIRPQFRLSEYSSPHTDDGAVDLVSALTFGTAEFCPLERQSFVFHHATLDSTPVLRKLTMASDDSRDYISRQASLIIKSNGVYSVSAAETFDTGPPSPRSSTHGVLPSQNDPLKLTWRFEYLVEDRRSDGSVIAKQGEKTLTPLSFSCSPGLLHPTHGKKIRLMQVMKKSLTPKLASAKVLSEAQSPDFLAPPSPQQEPILLLNGTKAMHRRAHSSSVGVSYENEDRDRALSEGPRIGLKKHRTVSLMMPSPHRTSEEQPLLPARVPSPKLFRHIVPPTELAVLLEARTDLNAIPIATHSLKPATRHRHGLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIA4</accession>
    <name>A0A2R6RIA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIA4"/>
    <dbReference type="STRING" id="98765.A0A2R6RIA4"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="6">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS29757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="13283" checksum="7524E7702216B72B" modified="2018-06-20" version="1">MIFPNCFHQQNITRSKEEAIEILRGYQAEINGSPERFAELAKVHSDDSSAKRGGDLGPFGRVRSCLFFCILSSTDQERPWNIQGQMQKSFEDAAYGLNVGEMSDIISTDSGVHIILRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLH8</accession>
    <name>A0A2R6RLH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000243">
        <property type="protein sequence ID" value="PSS30872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLH8"/>
    <dbReference type="STRING" id="98765.A0A2R6RLH8"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS30872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50496" checksum="AB4249418FD2E089" modified="2018-06-20" version="1">MSISTSGFKAHPSTSSLASLASASRSPSGPRNPTGLRSASTPTATKFSDTASIAGTSIAGVMTSSSRQKSRSKSPGSTTMRDRERDKERDGDKEKDGKDGKEGKSGQGSKGSRGLATQPRLRNTPHLPSGKDVEPVPATLMYWSRAPVYGLLPTHGMRAHSITLVDNIAWIFGGCDEKGCWRDVWCFSVESMQWSNPDTVGDIPPPCRAHTATLVDRRIVVFGGGEGPVYYSNLYVLDTITRRWQHPTFPEGTDLPPPRRAHTSVLYRGRIYIFGGGNGTQALNDLWTLEVGTNANVEKMRWEEQQTRGRKPSPRGYHTANLIGNVMIVMGGSDGRECFSDMWCLNLDNLNWSQVRLATSYRRLSHTATQVGSYLFICGGHDGSSYTSEMLLFNLVSLTFETRSPAGRSPSARGYHAALQADSRLFIFGGFNGNEVFDDVHLLDLAGAAYLPQVTSFRIEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLY7</accession>
    <name>A0A2R6RLY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLY7"/>
    <dbReference type="STRING" id="98765.A0A2R6RLY7"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="12449" checksum="C5E7CBB9165D3E79" modified="2018-06-20" version="1">MLNPPPAPLTGFASIIPSYGTHIDRTALELRYKEAIASLSERLGTDKWFLGSTGPTFLDALVFAYLHSILHSRENLLRFEVTRRVNLVAWERRVQAEVKVPFRRYTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ46</accession>
    <name>A0A2R6RQ46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000193">
        <property type="protein sequence ID" value="PSS32153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ46"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10694" checksum="457486DC3FECD72B" modified="2018-06-20" version="1">MSPEICIDLLGQVLRSKSAREDMHGEKKNQANLQAMHLDGDTAKVVSSLAVIWRMSPFQRNQLVNKQAAAVDIRKISLSIRHSSDLYGFRGIWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVL6</accession>
    <name>A0A2R6RVL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000159">
        <property type="protein sequence ID" value="PSS34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVL6"/>
    <dbReference type="STRING" id="98765.A0A2R6RVL6"/>
    <dbReference type="OrthoDB" id="2801766at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="21427" checksum="98047F4157A9E1F2" modified="2018-06-20" version="1">MAEFHNWSLVLPEMVEVYLQQLYATPQGDTELPDLSPRTTELLLPTDTPSPASANATPSDSGSTAYPPSPANGSAVPSSPFKAGYIGVSPINPSLAISIKTLELYRQLHLRKVSFSAEAFAKVLCDYYMQIPYNRRYRQVLADAFDVYLQIVWIVDKRIQTALSRNGENWHVLNACPPCKYKLNEELSLVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVZ3</accession>
    <name>A0A2R6RVZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000143">
        <property type="protein sequence ID" value="PSS34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVZ3"/>
    <dbReference type="STRING" id="98765.A0A2R6RVZ3"/>
    <dbReference type="OrthoDB" id="2791589at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="260" mass="29534" checksum="8762A1D1D6269BF1" modified="2018-06-20" version="1">MLRLRPSTSIFRPFPCRNIPHVRFITPAIPGASGKPLSNLDKPPYYTDPADITKYTKANASNVSINTPSEEGEPVQVHIEFSEEPIGLRAADGYGYRRFDINDLLDGRYTIVRKIARDVPFTTWLARDSIENRFVMIKALTGHYTARGSDFLEYDMWKKIAAAHSPHCWDLYHSFIAPGKGSAARSFESDDYEYTNDEYSMLTRAPEMLLGRSWNQSVDIWAFGCVSNPLDMTPGLALLNTSYAPQNSRNLRYQRQTPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3F2</accession>
    <name>A0A2R6S3F2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose-binding like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3F2"/>
    <dbReference type="STRING" id="98765.A0A2R6S3F2"/>
    <dbReference type="OrthoDB" id="10052260at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16323" checksum="EB783C0F8BC3AE9E" modified="2018-06-20" version="1">MAQGDVQLINAETKVKVSSTLDKSVGKKFLTDGSPETCWTSQQGTPQFIQLSFASRIIPKTIHLTFQGGFVGTRCSIDITVGRIEGNKGEWKTWTNVYPEDVNRRQSFDLPPVEEGIQDMKLIFEESSDFFGRITVYDLQVLGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3Y2</accession>
    <name>A0A2R6S3Y2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS37000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3Y2"/>
    <dbReference type="STRING" id="98765.A0A2R6S3Y2"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="8">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="18294" checksum="C853F396996D2718" modified="2018-06-20" version="1">MKVYALAVVLAPPQKTCTILSSASDLSSFSFYQRGSVGEFLTFFSKTISERTPQGERQSVQENNYTAHVYNRGGAEQLAAVIITDQEYPVRPAFSLLTKMLDDFTTKIPQTSFSNPTAINFPEINTYLQKYQDPRQADAIMRVQQELDETKIVLVSVPRLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4R1</accession>
    <name>A0A2R6S4R1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4R1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4R1"/>
    <dbReference type="OrthoDB" id="2799313at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="166" mass="18782" checksum="B82279CF6B651FBF" modified="2018-06-20" version="1">MDYPENCQLPGLIVPQVVFSAPQPYARRESIRFTENGRPGILLRHACSENFSGMADRATYPTLTTTSMKITIRINWPGYPPWAQQMHAFTHASVSEPITKQRLAYDIARLVNLFLNDMANVQSMDRSAPGIAWSVPNIRLDDLVLLELRHVSTGSWQPVLCRMVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Z2</accession>
    <name>A0A2R6S4Z2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v858</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000067">
        <property type="protein sequence ID" value="PSS37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Z2"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Z2"/>
    <dbReference type="OrthoDB" id="2953893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="13">
        <location>
            <begin position="131"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="463" mass="51397" checksum="5D91BFF1C3DAEACF" modified="2018-06-20" version="1">MSDLPPLPPHIMYGMLFLETVQTALTGADAYYWFASGFGDIRHLENSYISAFDSPFLSSVIALIVQFFFCHRIWKMEKKFWSFCVLTAAVSLTQAAGGIASGVVGLENNNFAAASRKLGQTVAYIWLLGDALADVMIAGAMIYLLQRARSTDHERTNTILAKWVRLTMETNAVTAAVATFAFVLHVAAPEQSYFICPTFFIGRLYSNSLYLTFNNRLSFQTLPMRPAPSSGSSNTAVTKAVKTSQGSFSSAGEASPSYIIGTFEQSVVVDGVELDTLNGSVSLRQPLSVGFKLMSLSLAFLALSLALCISCAHYYTLRRRGNLPPGPVGLPFIGNLLDMRVLFHPEALTKWSHEYGDITYLKTFSKMFLVINTPKAALQLLEKRGALYSDRPQQPMACDLVGLNRVVILTPMGERFRQERKLMNTVLNPRAVTNWEPLMTEQVQAMLREFLEVPEQLSDNLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S505</accession>
    <name>A0A2R6S505_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S505"/>
    <dbReference type="STRING" id="98765.A0A2R6S505"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="428" mass="44922" checksum="D9C0EBD2E0B0A7E4" modified="2018-06-20" version="1">MLPLYLPAYLDVSQAQNPALSYGADGIVGLGFTSLSTIDALVNHTGASTGRSLLFNAFAANPSEPNYIAFALQRSSDPDADDVEGSFSIGEVEPEYSAVLNSTAVSTWPVNSPSRWNILLDAVLIGSKTIGVSSSVQGAPSGKAVVLLDSGTSYTYASEDVCTAIYGGVSGANFDSSLGQWIVPCDAEIDIALQIGGKVYPIHPLDLTPASLTDPSSCVGTFIPQPVAVGAGEFDWLIGDNVLRSMYSIYDFGDFDSAGNMGNPFVKLLSLVDPNQASAEFHQVRGGQPLTNITYNAANSTSASGSLASGGSTTVTLSNELADTLTKVGTYLPALLAIMALNALVILLLIAAAFVYMFRRRGKKVRARTNPGRMSPMPMNRTSSFGLPSDPSPAHTYEPVSMALTDDTFIPPSAAFTKESKMRPNSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5D6</accession>
    <name>A0A2R6S5D6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v717</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5D6"/>
    <dbReference type="STRING" id="98765.A0A2R6S5D6"/>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS37510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="246" mass="26882" checksum="2FE0289B2AEA45EC" modified="2018-06-20" version="1">MPFIQDAFTLRRNSFNVRRATLLNGFVATGAGVFSNQLVGLSHSFASPFVASGALLLLAFTVIKGLWAENYGSTDATADDTKAGFFQLKRLGEAWNIVRKDPYLLVIGLTQTCFEGSMYLFVFLWVPALQEASLSTAALPLGYIFSCFMISMMLGSLLYTTISSYSNRSNPGSTAHEEPLILNAKLSSLVCAVSALAFAVTITSRQDEHVRFWAFCAFEACVGMYYPVQGMLRGSLISNEHRATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5F9</accession>
    <name>A0A2R6S5F9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5F9"/>
    <dbReference type="STRING" id="98765.A0A2R6S5F9"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="214" mass="24906" checksum="B040D900ECD5BFBF" modified="2018-06-20" version="1">MRRIFYEKKIAQEVPADSLGDEWKGYVFRITGGNDKQGFPMKQGVLVPYRVSLLLSDGHSCYRPRRTGERKRKSVRGCIVGPDIAVLSVVIVKQGENEIPGLTDVVLPKRLGPKRATKIRRFFNLTKEDDVRKYVVRREVVSKKKEGAKPYTKAPKIQRLVTPLRLQRRRHLRSLKRRRIERQKEQKTEYDVLLAKRVADKKEKVAHVKATHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S691</accession>
    <name>A0A2R6S691_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S691"/>
    <dbReference type="STRING" id="98765.A0A2R6S691"/>
    <dbReference type="OrthoDB" id="2497682at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015329421" description="Protein CPL1-like domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="4">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="479" mass="51219" checksum="8C3120097C46656A" modified="2018-06-20" version="1">MTRFTSILLLAAVIPFALATSGSTKSDCKENEFFFEQKECCLPHGGPPSPPPSPPKGVTCPVSGWYWHTGKQCCVPHQPPAPSTPAPQCDKTCFWSSLDLKCYPGSSSSPPTSTTPASQPSAKPGNSNNNNNNNHHKRNMKSRSASLCPNSMEACPLKGLTATSNDYECLDTDAELESCGGCASTGAGQDCNAIEGVWNVACTSGSCVDFRGLKPLVSMYSPVRAMVFVLNLATFALLVLVGSASLGAVSVLAVPLPLPMMIENAGYARQPSQNMSTPSVQPPSAAVERRDLLSSIENLAAAGPALRRDVTTTLGDINILNQYFDSMSQHASNFKTLAHQPASERRATYQQESANELTGFHTDLLGFQTILDQLGSDNGLANYDKSDELETLLKNMVNLNKYTLSDIDDMVYDLPGVGSTLGPIVYEIKCILDKVLDAVENFADPILHAIKPLLQPIIIQATNLVCNSGLQLDGLCVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6S2</accession>
    <name>A0A2R6S6S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6S2"/>
    <dbReference type="OrthoDB" id="3346544at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="260" mass="28794" checksum="8D7546CF9F9CF188" modified="2018-06-20" version="1">MNCFRMIEGYVIHRSDPGGPVAYIGKLAPWDHVFKDTLYATQEILGDAVAVLSGYTVCGLYPSENSNSSVFDPRLLHWITTFYAISVVQSGITTFLMAFRIWQTDKRSATYRTNKEGNLMPILRILVESAFAQFAVEVILLSLYAANYNAQYLLLELVTPLVGITFNAITIRIALRQAETFVATRSAASFGHHAPTNNHHDIATIGSIPMRPMPISISITKDVEAHGDINSDHGSTAVGYSDYERKQKRSNSDDDIATVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S793</accession>
    <name>A0A2R6S793_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000001">
        <property type="protein sequence ID" value="PSS38146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S793"/>
    <dbReference type="OrthoDB" id="2745780at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="12124" checksum="3F348E15BE822746" modified="2018-06-20" version="1">MDSLPVELAYAIFAQLKARKKNKQDLASCSLVSRRWRQITLPQLFEKLRITYRVHDYSKEACPAESEGKSHILCNETNDADLYLRLAQEFEAHHHTSFCPDLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S795</accession>
    <name>A0A2R6S795_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v42</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S795"/>
    <dbReference type="STRING" id="98765.A0A2R6S795"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS38135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="132" mass="14777" checksum="AB2B9C881CCC27C9" modified="2018-06-20" version="1">MHFETIYASQDKRDDVKAGVKSTALLFGNYIREICAAFAAVFIACLAYAGILNGQGIGYFLISVLGSALHIIWQFYTLDFDDSSQCGRMFLLINAPFLSSLTLDFIQYTENFPFLEAWKDLCPQVPRHGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE73</accession>
    <name>A0A2R6NE73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001342">
        <property type="protein sequence ID" value="PSR70636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE73"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7083" checksum="0DBF5AB5FE9A74DA" modified="2018-06-20" version="1">MANDSVPTVTDVGANPTPNVNQDTNGSADDEYPAFDLGDFPIDDHRPFKVIVIGAGASGIHAGIRYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NED5</accession>
    <name>A0A2R6NED5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NED5"/>
    <dbReference type="STRING" id="98765.A0A2R6NED5"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="584"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1157" mass="123662" checksum="30863F42FDA4FBA3" modified="2018-06-20" version="1">MSIKRDALFPPGSIGRSQGRPLSRTGSYESLTAHPLLSPTVPGSSSSPASSTTTLDTTATPAPATRYVPYTPRQRGTPTAATTGTTIASSIQSSPHHQPFHGDATSKLQLMNLKAAAQKGGLDSASVGWAILEKLGTETDRGPEWNEIWGAISTGKATLLLPLEAHHTNEPISTEFIKDHVAFWDVSNKTNAPLVTLSGLRGTMIDEVLTIRSTLDTSSKHFKAILDPSSRTSALISLPPLPLPISETLGTGSIPSTPSSPPPPLPVSPKFASTPIYPSYGLTSYHPALPLPPRPQAAPSSTNSTPSKPPLPPRRPGAPAANPLAPSRLSNPFASLFGRSATPDPPASPTTVTSPLHPATPLSPSDSHSQSTESIEHVPGVPAYTLSRRIVRRDLARNMLRALHAEIRLGLAPSGAPGWVSERIEEFAEREGLLPFVKVKNGRMKMDEGSASGYVIGSGVSSKDEGMQEIGRKFQELYIDIEEQLEKRSWRARHSFGKGLVLHHLNGSSISSSAESFSGDEKADRESVKEDGDDTEKESESDERPERPEDEKEKRIREVVEAVERTICCLFYDRLFLQSFADDATHDEALSSRIAAVNLLDLTLSHLGVDVGRSGKAVGAVIKACGEALTQLDSSCRAPADKAAVLVASHRIIVDGLSRLPPIKLKPEDEMLDEKTPMAGTFGHRAVDEEDDNVASPLEQSGSGTFHDSPTVVFRESPTVVLSPESEHTPSGPLSDISKDDDGAAHGSPADDESRSLQPPPHRAPSPCLTISPPPPPSSPTPVSGDIILPLMIFAAVKANPPHLVSNLLYTQRFRNQAGGGEEGYCLINLMAVAEFLENVDLAALGLGESEKTVISTAELTPISINRSGLGSEPTSPRSGHASLRGRVEQQVDAIAGSANKVISGVVDSSFGVLRAFLPGQSNVDGAAAADGDLQDTAPWNAARPGFGLLRRDTGFSIASLAASLPGARAKTPVQRDEESGQQLVEVPSRPGSIRSVRAPEVSSSEEESEGDEEEEEEEEEEEEHDTRSIRSFESMMSGRNKRKKPITRKSLTDRLASMPGLSRLSHSGQQESSKLSPPASRRSSLLVPPTTHQPHRYESPISSRDASPVAIRISPPNARFLEASADDIKVSEVGELLREYKRLVEAVRAMGGFHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEG8</accession>
    <name>A0A2R6NEG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001323">
        <property type="protein sequence ID" value="PSR70787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEG8"/>
    <dbReference type="STRING" id="98765.A0A2R6NEG8"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="173" mass="20617" checksum="496FD8248BA10421" modified="2018-06-20" version="1" fragment="single">RSPLLMERKAARMRKEMESDPEKATAREIRTRFDHSDRHWKQIFAKSLVRPFKLFWYEPIAQLLGAYMAFVYGLLYLFLTTIPGIFERRLVYVGLHTGASQINARFMDRIYMYYTKKNGGKGRPEYWLCDIDGSRDELPPDWPLHHWLDRPSTHTLDGARHREFTFRHPVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEL6</accession>
    <name>A0A2R6NEL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001323">
        <property type="protein sequence ID" value="PSR70786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEL6"/>
    <dbReference type="STRING" id="98765.A0A2R6NEL6"/>
    <dbReference type="OrthoDB" id="2756789at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="36834" checksum="A6A897DCBFEE1E40" modified="2018-06-20" version="1">MARVDPHLIFACEVILDVDGPLLRSMRTVQHSYIRRRLGLNKRSSTAVLFTETRLWPIRYRRVYLALQYLAYILRESPELALLALHELVALCAEGKSSLMGDLNHSLRRLPVPVIMEEETALTVPNVQILLNLVEKSMWEHLEEQVESSPKFVLLHGRLEYIQKQRSMEHRTLAFRDYLQVVVPDHRKALARLVCSDHPLAIEQLRRTAARNHIPRMSRTCRFCRIPGTVESEQHALIDCSNDELVSLCESFMTKAIQAVPAIARQRRELSSISFLRALLSWTRVTELLGKYTHRIFRLCTLTPLLIHNDFVIDGEGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF91</accession>
    <name>A0A2R6NF91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001302">
        <property type="protein sequence ID" value="PSR70928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF91"/>
    <dbReference type="STRING" id="98765.A0A2R6NF91"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28360" checksum="843ED48F00C187A7" modified="2018-06-20" version="1">MSSFQGSNLFNVSGKVVLVTGGSRGIGKSIATAFVSNGAKVYISSRSAKDCDETAQELNKLGPGTCITIAADMQKLSEVDRLVKELSEKETTLHVLVNNAGAAWGDTVDDYPDAAFTKLLTLNLQRVFSLTQKCLPLLRAAAKQGGLDGQTYRDPSRIINIGSIEGLSVPNHETYAYSASKAALHHLSRNFAGRLGWEGITSNTIACVMAHTLKTLGDIIVGSIPLQRIGRPEDVGGTAVFLASPAGSWVNGATITLDGGAIVAMPSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGD8</accession>
    <name>A0A2R6NGD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGD8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGD8"/>
    <dbReference type="OrthoDB" id="3071736at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="440" mass="47732" checksum="7E94A030506CE62B" modified="2018-06-20" version="1">MSTTRSIHTHATFPSISSTLSLLEERKTEVEKRSGVLVTELDPQEAAVESNRTSSSESTIIAHAARRSNREALHVLSVSNGSATFPKRNIRPTLNLSTSSPQLRELAELANVPPSPITACSPMPQQSSFVSLATSISSPLASSSMLLSNNASRWSVDSTGEKERRPTVATPPATGDSPSSSAKPRKRDRLISFISRGRAGSLGKQQNSAPSTTPNSPRGEYDMLSPYESQFGRVSSSSQASLPIGSRRPSRTYSITPIASSSSSSSTLPTPADSQSDFIADPFCPASPTFAPVSYLPDFESPTEATFDMGSYSPPAPTHPLPSPGVPTSSFFLPVRERQPSFPFLSAMSRKKAQRRKKILVISSISTAVDPAPESDGRLQIEALRREREQKKRVEGVLRWSEGFGPVKRVENRPDGSLHVHWKDWETADLVSTFLTCFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGJ8</accession>
    <name>A0A2R6NGJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001274">
        <property type="protein sequence ID" value="PSR71515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGJ8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="15946" checksum="BED4B79CD480926A" modified="2018-06-20" version="1" fragment="single">VSIPVPASGNEWIVAEVIRNEFATECNTQNTIDTTAVKRVKAKSKEKEEDNIIHGISNTHRRPLNPKKETPPPPTTILTVVLAITGFVISAVRIAAPTTPKSPSKTMMYSRCRKQDMTGLDVVQCIIIPNGMVLQQVFKSVYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHY8</accession>
    <name>A0A2R6NHY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001236">
        <property type="protein sequence ID" value="PSR71868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHY8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="9782" checksum="CD6D2F8B26C4A818" modified="2018-06-20" version="1">MFGERVRRQGSVGYRSVRHPESLKVVRQSRKDKREEQRCGGLQGMGPSHPDKPDSPSSPFSAAQCATSPQLEISNNAQQTNDDNRKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIA4</accession>
    <name>A0A2R6NIA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001214">
        <property type="protein sequence ID" value="PSR72114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIA4"/>
    <dbReference type="OrthoDB" id="2317741at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015317737" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="12332" checksum="33729410DD5BBE5A" modified="2018-06-20" version="1">MFFKTALLSAFVGLASGAALDVWSPRITSPDAETVWKAGTLQQVTWDTSNPPKQISNPIGMIVLPKAGVLDSDHPLATDVPLTAGSWSVTVPGVAAGDDYTVVLFGDSGNASPEFSITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJH1</accession>
    <name>A0A2R6NJH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001160">
        <property type="protein sequence ID" value="PSR72519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJH1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="7912" checksum="7207F1E7C0033911" modified="2018-06-20" version="1">MEGEEDVVVSGVGDAASAPFCTMPGCWDPSALFTPLTMRCFRYFINTMSGGLADLALLPSVTMLALSAGAPAPCAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK62</accession>
    <name>A0A2R6NK62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001151">
        <property type="protein sequence ID" value="PSR72628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK62"/>
    <dbReference type="STRING" id="98765.A0A2R6NK62"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="329" mass="36102" checksum="C7373A302061736F" modified="2018-06-20" version="1">MLVAESLSMLVRLPLFIVPLLVHAPVYFVGRLGAKLVEDEEETQAQNKVVFGLLLLILMYGSIGVFLWAMLWYTPAGALLAAGFVFLFAKYHNTLINDNYEHAKRLVAAWRILVGVWAPKHWDLSLTALAQYTIPRVPPENPWIDRPRTKSSPTTPNSPTPLSSPTPTPQSLSHKAGTPSSKTRKQRRPPSRRLVRHVLRARVEAAKALGTLFEQLDHASDGKRVRASSHLAQAFGGVLDEPAAPVNSSDTLEGVGEVEMARGWRNAKEVLSFLRNRGAKMGTLEHSVAGDWAALSSEGEGDGTECESDSGFAEDLVWVPSTSNLRQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKB2</accession>
    <name>A0A2R6NKB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKB2"/>
    <dbReference type="STRING" id="98765.A0A2R6NKB2"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="100" mass="11204" checksum="94A32EB040D33215" modified="2018-06-20" version="1">MAGMKYIHSASVVHRDLKPGNLLVNADCELKVCDFGLSRGFNSAPDDNPTNMTEYVATRWYRAPEIMLAYRAYNTAVDVWSIGCIMGELILGRPMFKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKM7</accession>
    <name>A0A2R6NKM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKM7"/>
    <dbReference type="STRING" id="98765.A0A2R6NKM7"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="788" mass="88202" checksum="C759D09286884A23" modified="2018-06-20" version="1">MSFVWGAVDGVHSPWRNLDYLSDTTKDRFISAYHVPEKALVRSSELFNSTVLELVKLIQAALSVCGMFDLSKEERNGLLCDVTCEGIQRWVTEIGESCANVEPMERVADPTVVAALFSTVLTVRNRLHAMGHFVPKDPFIDPLAFVKALTAFGSSKPHAHAHTLSLTHYSLQPPALSHSVTSSPVQAVYLSQSLIETINAAYDKAKQSDTYKVHRVLINKLDDLATDLRTNPEPGGSTKGLFRWASNLVPTTDLAGFVKTISESSKDGAPSLRYLWTGRPGEVARKRKEKEMIWSEGEEKEREKELEKEIRGKEKDEKEREKEVKSSEDEGDFLGGMPWSGRMQRKIESWAALGRTKKTSMDLGVRSRDGPDSPSRGQSEPASVVPSVVVSEPLDDDDILTSGQVSPASGAPTRSRLMFGNLPRAERSIGELSDYGRRVTEFNQKNPPAKPHIQGRIVSWSDPKTARDDVNSERGRTSKRRALSPLKDSISDAQASKDSLFELEQETSRTTAKRLQALKKRRSFDDADALRGTRILPVDRMRIDAELCGQILIMRRREQHLANVLACLDALTSDLSATNSSLRQDYTSKLPEIEEVKRRAGLLQDIEAARVRADALTQETNALAYESAQFFVDDLWQMAALPRQKVFVMRERVFGTGRRLPQGVHGAHGRFNREQFTLDGRGRLVDTLGRTESEVEDENELPGLSRIVHEDEEDVVEHASLKPTWLLRMFNYWGSKWGASGNVGKEKEKSQERQDDLRNRTTKSASMHESTTSAIESRASLSRNKTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM31</accession>
    <name>A0A2R6NM31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM31"/>
    <dbReference type="STRING" id="98765.A0A2R6NM31"/>
    <dbReference type="OrthoDB" id="2799711at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042859">
        <property type="entry name" value="NOL11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15633:SF2">
        <property type="entry name" value="NUCLEOLAR PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="26124" checksum="3E76F33B009B56B3" modified="2018-06-20" version="1">MILALKTVVDLSEADVVSLIQVFVSAHCENKPSSEGAMQVDESTSVAVPSLPSVLSLCLSYPTSAAALRLAIRQQLRDSKDLTCILQILSGWLDSWCEDDVQLLPERTKKDLHGALVPVLEDKRKDTVPPVNNVLAFLQTLLDSSYLTFLSYQPSHDLLQHVLSQLLPEVTFSDEVEQLRGPLMPFVKAHTKAVHESAHGVQKPDLKVDWKRRRKQAHEQASIAVGVYQIEELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMA7</accession>
    <name>A0A2R6NMA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMA7"/>
    <dbReference type="OrthoDB" id="5522061at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="18402" checksum="EBA584B3AB05BBF2" modified="2018-06-20" version="1">MFTSQQCSTLLRKTLASSTLLRGGLTRRSSRLTPGLSDSVDGDGIPLRPTWSVNELLSSYPKPILEPSTLKRLHELSALIPPEEGTPGHAQLTSEMESLIKLVEAVKLVDVGQGSEEDGVPDGRIWAEGTGIELERDLGDESSVQGQALLRHAARTDNGLYVVDADRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMV7</accession>
    <name>A0A2R6NMV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMV7"/>
    <dbReference type="STRING" id="98765.A0A2R6NMV7"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="8762" checksum="E78C31314B4BE133" modified="2018-06-20" version="1">MRYAVLVTGPAGAGKSTFCNALLTHLQTSKRSAHLVNLDPAANNDAFEYEPAIDIRDLVSLEDVMGELEYGPNGGLVYCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMY0</accession>
    <name>A0A2R6NMY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v10430</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMY0"/>
    <dbReference type="STRING" id="98765.A0A2R6NMY0"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="219"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="430"/>
            <end position="433"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="498"/>
            <end position="499"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR73740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="512" mass="56341" checksum="84FD92A2C22E542E" modified="2018-06-20" version="1">MTETPLISWPPELAEEQLTALTLQATTYALSHGLVYLPIAKTQPPAPTSTIHAPLALFPSPIPRKLFEQARALQRIYNVLYSRVATDVQFLDNVMGEVEGVGKVDEFTGQLWRRWKRLRDEGITQSLQLGLFRSDYMVHLPDPSGPASLKQVEFNTISSSFGTLSERASALHRYLHSSTGYFGSSPCLQTANFPRNSTTSGLAEGLATAHSAYSVPEAWILFVVQEGERNVFDQRWLEYELLESHSIHVIRQTLADLATSASVDPKSRILTITAPSFPHAKGVEISTVYFRAGYTPTDYHTPAFYDTRYILESSRAIQCPSFQLQLAGGKKVQEVLTKPGVLEQFLLDESRWGDEAFSQAEVDAIRGSWMEMWALDEGIGGEGVQKARDLAQTLVLKPQREGGGNNVYKEAIPAFLDQLPTQEREAWIAMRLIAAPQGLGNYLVRAGGGTESAVKTEVISELGIFGWALFGGTDGKVKEKEVGWLVRTKGKDSNEGGVAAGFSVLDSIVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN36</accession>
    <name>A0A2R6NN36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN36"/>
    <dbReference type="STRING" id="98765.A0A2R6NN36"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="170"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="37587" checksum="0223950E47CB730D" modified="2018-06-20" version="1">MNSTSLSAAFTNAQQHYLSTARPFYYVPESRLVSLLPDNLFSLAAPIIAYWVSSLFFHALDCSNAQWLQKYRIHESAEVKSRNLASRGQVIQAVVVQHILQTMIGLWWMEHQPTGEEVNHLANMAGEASFLVPVLQRLFGDEEGAQWWLTHGHEAVYFVYWWAIPMAKLLFAMFIIDTWEYFLHRAMHMNTFMYKTFHSVHHRLYVPYAFGALYNHPLEGFVLDSVGAALAELVSSMHTREAIFLFVISTLKTVDDHCGYRLPWDPLQLITSNNADYHDIHHQIIGIKSNFAQPFFIHWDTLLGTRMTRQDIELRRRKVAEKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNA8</accession>
    <name>A0A2R6NNA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001052">
        <property type="protein sequence ID" value="PSR73871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNA8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="185" mass="20463" checksum="5AF08CEE46582E98" modified="2018-06-20" version="1" fragment="single">MTTAQSTTSLPCNNKTHCFDEEDVRDRYYDSTRKPPWDTCKELICPNHYTFPHYTSHKDNTWAKPTDPDQISRIIEYHKLSEKRRAEVEEELAQRVQLSRPSATVAQPVASSSSTVRTGPTSTTPRPQTPKPSQIPIARSASGSGTPTQQPIAQQQQPPPPPNPPSPPPPTTVIPMAAQNPSLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNV5</accession>
    <name>A0A2R6NNV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hamartin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NNV5"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="665"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="801"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="920" mass="104104" checksum="864C26CDBD490E88" modified="2018-06-20" version="1">MAVSELSPQLRLLLANSPDAPSLPHLLQSVDHFVSECSRSTESDSGALLHQLEDDLQGIYHEVIDHSLLSHVKAFLSVLFHLRPILPPSSIISTWFDLVLRPALREPKLPAEAVDHAKELIIAALNPGAPKDDAGEGGPDPDREKKQDKIRDFRRRLMDLYLLDAHNESSGDDVLEWAELDDAQKERKACWKANLEDVLVRVGLQRPQDLLTELYHCFASPSSRLQLLILLNAYTSQPDFSLHAAILASHPLIHSLLNCLIFDNSSTECTVGITVLTKLLPLFAVKACEDLKRLLPSLYVVLARIVCWETRQPYTLPDLASEATRSRDPNILLEPVVDDKRDEFASDNSNRLHVRSELEWARLDKTFTGTASSAPPRQQYFAYLYFLFPCNTIRFLRGPVSYLTERDLESPYTVSWEDALDDDKIRSTSESLLRGHSLHPLLIWRDASEELSQPDFWAKYDVPRIVTECTMLDVRSASLGVREQVLANASTLSSGMVFNRPSDPPVQPASLSSSTQSGSSLAIAHLEPVSSSRLRISLQEMISTSIALKSGLDVEVVDFPASVAWPAILGDHGARPHSPSRSTASASIRSASPEVTRQHELDEGIPSHVALAIAGLQREVLMLRSELNFELWMARENVKHIGRLYQDRVLSRTAEMERQGLHNRLREYKGEVYRLNKDLKEQKEQAQNVRIQYADWNKKLQDKIKEFRHEKNSWQTEAAALRAADKEAKATFAAQSKLLTDANRQVFELQTKIKENAHKVDRLRDYERQIDQLIKLQRLWEIDVQKLNDQTESLQIYASRYKKMEVRLAAYEATQVELENKARSQRQTIQSLEARLSITKKQLNVSRKATPQKDLAAYRDEAKQLLEINSRLREENSEVREEMEEMKAMVELLKGQVSGRQGVVSDPRASPFLGPALGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPC5</accession>
    <name>A0A2R6NPC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000995">
        <property type="protein sequence ID" value="PSR74344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPC5"/>
    <dbReference type="STRING" id="98765.A0A2R6NPC5"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="532" mass="57597" checksum="F9CABB669BF165F7" modified="2018-06-20" version="1">MECPNCELKQRQFYCENCLRQHLLSYRLQTSHVSSERDAHIATAQKFLVTAVEPARVKRADLKSTEERVREIWDSLETIRKANEKTKERMQSLRESLATRRRMLASAIDSCPPPSPSSVSPPLAQLSGSPGHGFGVNLQTARPYLAQRRLSGTSSHSPPPRTLSSTSRQPFPSISTNRLPHTTPASVPGDSARQIEEATYRLTALSDTIARARSGLVQELVEVFSVVEVGGRPPLGGKAGTKGEWTIGGLVLPVPGDMRRYPPDHINAVVTHTLHFLSLLAFYLGIKLPFEVIWSRSSTPPTSSSIAATSSISPSARTHGLLGVGTPWIGATRGGENGGWARWSTKHPLHVSATPPPSLASPPPPNVQAGRSPGHQRSVTMPTTSSLSRAKSIPVSTLEESHIEEPPSTTASGSSFTTALAMLLYNVCYLAHTQAVDVPLAQAGEALGNLWAVCCSPELGRKSHATYPLLPAPTPPNFPLDFAQLLQATAANPSRARARGVAGKTNMRNDRERERIVEEEDGWDLVDYEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPY3</accession>
    <name>A0A2R6NPY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPY3"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="332" mass="37438" checksum="9C08D729BD09D0E8" modified="2018-06-20" version="1">MVYQMLDCLHDLRYKAKILHRDVSANNIMWEMQGEEVVFKLIDFDFATFVDDEGKATDATARSKHRTGTLAFMAFELVKDMAHRDNPLCEPVFHLLHHDFESLYHLSAYSMIVIPEGEDADKRELYRESVWLCENGMMQQIAACKALSWEWRRMRSLRLPPQSEPLRPWLLRFSDLLYAAQQKVRIHDMDESVLFDHETMGGMLTRDVITSVLKGESVVTYGDVSFVPVPQEACGSGTSHEEMIEEKATIQNESTKLVPERRAPAKKATAKGKKVATAKAITPKKIAAKASKTKDTASKAKLVVTSGTMTAQALMRRGPTTRSMTKNALIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPY4</accession>
    <name>A0A2R6NPY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPY4"/>
    <dbReference type="STRING" id="98765.A0A2R6NPY4"/>
    <dbReference type="OrthoDB" id="3260348at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="654"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="945" mass="106336" checksum="BA560E6A1C238BDF" modified="2018-06-20" version="1">MITWSHDQVALAACYRLAVRELTLRFELCQNRADLDQAIFFHQLMGDLPHRALQSLDRARPGASRRGRNISTLYDWQITHSSLLLLRFTDTGQSRDLQSAIDMVEPVLEILSEGDTLREEAFACLVSCLMQRFRVHGRLEDLGRIRALVVDDPAPSINNVYNLGKLLLTAFEWFRQPELIDEAVEYLHQCVDLARTVQARKLPHNGNAETSEMEEFTFAQAALEQRYGAEVISRYTRRSWRQGVFSPDNSLMHVSNWIQETSRLHDLGRAITIQLANSLLYDKRQMTIALTVLRLAEQLAPRNSSQRWEYLFSLGTCHRVRHEIIPEQIELGGTRIGLDIKRAIELQSKAVEKLHFLSPRRVPAVSSLAHSLLRSASYLGDESQYYKAIELLEQVADAFYGFIHDRLEGAILWASLLHSKTYPFEDEQTRLQRSLEGYQKAISLLARAAWIGLSTSSRLARLHSVPKTFASDAAACAIRLAELQTEPQQREEYLGKAIELLDQGRAVLWSGASQLRADLRLLSSHDPELAVSLDKVGHELARTAFKDGNADSGRTTEALAHQWEDLVERVRELDGFQDFLKSISFTKLREAAASTTTIIVNISEHRCDAIIIPSQGSVRLVPLPKLSKSQVDDNVQEILGVLPYYDDRGELEAILSDLWLSICQPVLTELREIGVVGQKLRTPPHVRWCLTGRLAFLPIHAAGPRYQSRRKPGMLDWVTSSYISTLSMLLRAQQRREALQGKVPVPRVLAVCHSGGDERGRLPKAKEEVEILCSCLEPEAVSVIMDKAARVDAVSDALKKSNWVHFACHGTQNKTNPMDSALVLDDGRLPVSKLAEQNLKGEFAMLLACETAMGMPGLSDEAIHVAAGLHFAGFNGVIATMWSICDEHGPIVAEKVYKYLFRRKQDESPADALEAAYALRKALLYLRDKEKLPARDWAPFMHFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ07</accession>
    <name>A0A2R6NQ07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ07"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8028" checksum="EB20BAA78BB54E84" modified="2018-06-20" version="1">MSPIKRSQQIRIENSVALLVLLIHHHNLLPPAVYTMSGDLSHKMEVGTMASTVRGDADEAELARMGYKQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ19</accession>
    <name>A0A2R6NQ19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9683</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ19"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ19"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="15375" checksum="9B58175FA068C9F7" modified="2018-06-20" version="1">MTMLIAQAHPWFRGIDWDNIHRYSAPYRPELKNPEDTRHFDEDIPPEPLAPANGAAPDATRDPLLRHKVHGNEILEVRKALAFAGFTHKSPRVVSYVRADKAFDPEPDTYGHDEPDRGRSTIRGVLEIGKGRAISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQE4</accession>
    <name>A0A2R6NQE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQE4"/>
    <dbReference type="STRING" id="98765.A0A2R6NQE4"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="262" mass="28738" checksum="927B70B752B143DD" modified="2018-06-20" version="1" fragment="single">MRAHVEVDTTVKMACLDVGLKLKEHFSAISDVQLSGLSSKHSARVMSLMNESSPVFAQDPLFNGGSDVPGQNYELLALAAARPGVEAVGSAPYAEHSVEAAKKNVLLLFQLAEKYSLHLDFHLDYNLDPSSEPLIWFVLDHMRDRIRLGAWRRIQHVCIGHATRLTLWTDDEWTRFSKAVHDDGLPVSLVGLPQSDIYMMGRNVPYPGPPRGTLNPVRLAKEHSLTVALAVNNIGNAFTPQGSPDPLALCPLGIALFQVGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR00</accession>
    <name>A0A2R6NR00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000964">
        <property type="protein sequence ID" value="PSR74694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR00"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="26463" checksum="9C706D5C90D48BB9" modified="2018-06-20" version="1">MGLRKWNDAEWLFLWESYNQEDVRTILADNDKQGIPVDGKAKKGRAKDHRDGGMKKAAKLIYDKYIVQFPNPRVAESEQDFKQRQKTMAATYNRFHFRAQRGVGETQEQFDVRKATKLFEAIYHFVCERSPNKQRRTHLVKLDLYAAPLKPRPKSTAYTLFKEDHPHKPGAVLGEDGKKSLIGEWNAASRQAFARLPDDEVQRLESEAEAINACGIVPQGDWAMSEAVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRT1</accession>
    <name>A0A2R6NRT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRT1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7898" checksum="87BAD0EBC306DD41" modified="2018-06-20" version="1">MHIYGQPSPSRYSAAREGITQRQSILMRQAEIQALRFRKKRPRFHIPSWRKATTAAPSGLESHLLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS36</accession>
    <name>A0A2R6NS36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS36"/>
    <dbReference type="STRING" id="98765.A0A2R6NS36"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="6">
        <location>
            <begin position="89"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="254" mass="28244" checksum="A22BCD54CCDBC3E5" modified="2018-06-20" version="1">MEFTSALQKLGGYQPRKSQKSQEVLQKGTSLLASQSFASKGDDGKHPSLWESFEKLLLAAMDQGDMDVADECLKVLVEKFPDSPRIDCLTGIVLETKETPETALSFYDALLKDDPSNAAAWRRKVGILKRIGKIDKAVEELCKMLDTFYTEVEGWMELADIYSSCQQYTHALQALSHVLLLAPQNPFHVLHFAETAFLVPDVPLAFKMFLQAVDMTDDEDQDGVSPGDTVPTGLALRAWFGVKLVSRLIPFPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSA0</accession>
    <name>A0A2R6NSA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSA0"/>
    <dbReference type="STRING" id="98765.A0A2R6NSA0"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015341745" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="560" mass="58932" checksum="1F91B98893645960" modified="2018-06-20" version="1">MFRPWMLLVLLFLSQTVCAIGWPHFFAARATTTTSATLPDLYEASVVELQAGLDAGQFTSVDLIKAYFARIDEVNLKGPQLRAVLEMNPSALAQAAELDKERKLTGKRSMLHGIPILLKDNIGTVASEGMNTTAGSFSLLGSVVPEDAGVVKNLRKAGAIILGKANLSEWAHFRGNIASGWSGRGGQCTNAYFPHADPCGSSSGSGVAASIGLVAVTLGSETDGSITCPSSNNNLVGIKPTVGLTSRAGVVPISDHQDTVGPIVRSVADAAAVLSVIAGKDPNDNFTLAQPSPVPDFTKALNPNALKGKRIGVPRKVFLNDSISGNDPFVNVAFEAALDTIRGLGATVVDPADLPSAEEIAVSNNETFVLDVDFKIQLNAYFAALLKNPSGVRTLAELIAFDNANPALEEPLQFQDQSQLIEAEATTGMNASYFQSLADDKDLGATRGIDAALKEFNLDALILPAPGLTTVPAAIAGYPIVTVPLGFYPENVTIALAGPQTVYPAPGVPFGLSFLGTAFSEFDLIGFAFAYEQKTQTRLARKAFLEAIPKTQLKDILASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT64</accession>
    <name>A0A2R6NT64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT64"/>
    <dbReference type="STRING" id="98765.A0A2R6NT64"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="305"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="621" mass="69125" checksum="F4B84D589CFAAC13" modified="2018-06-20" version="1">MKRSSDVTSPNAKREYVEPTIPAREESLPVAKKLEAPKIPFGVNNRDNAPHEPKPSGVQDSAEDTRTRLKGIQTQISHLQVILSNAERKMNKSRADITRIVRLRKEMHDLKGQKDMYNAALPFVNGPLSRGASLSGHPRSGVASTSAVQLPPTFFGRQVTPANATATFGPLPAPCINSARPHSLPPVKMETAHSVASGSNAQLTATAVKTDMDESGNPAFDFGATNGTAVPMEYDHPQDDRRFDTDGDFYGRGKDLFVGPVAKADDIDKFLISAGNSESFDGNASLDKALLKLGLKDLYQPLPGMEVALMPHQAIGVSWMIEKEKSSSMGGCLADEMGLGKASPIFLFPIALIATNRSQNPLGKSNLIVAPVALLEQWQQEIELKTNLGLSCLIYHGEVLSTSSVLTVLIKTPVSIGYNKPKRLEDIRRYDVVLTTFQTLANEWPDDEEVERREKRQKKRKARTSNGFVVTDDSEDETSPLKKKARRSWTSRAVTALSAIYRWCLTGTPIINGLQDAYGFIRFLRVRPWYDWKPFNEHIVLREKKQPDLATRRLQAIFASILLRRKKDSLLDGQRLIELPIKEVVLVKLQFTPEEREIYKMVEERSQAIFNKFLRAGTVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTN7</accession>
    <name>A0A2R6NTN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTN7"/>
    <dbReference type="STRING" id="98765.A0A2R6NTN7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34436" checksum="A3779099C36FA691" modified="2018-06-20" version="1">MPSLGTIATQLFPPKPKWSVEQIPDLSGKVCLVTGGNTGIGKETCKQLLKKGATVYLACCSQDKAEEAIKDLETQTGRTAIFLQTNLSGLDSVKAAAVDFKILERQLNTLFLNAGVMVPPMDQVTFQGYDMQSGTNVLGHFLFLKLLYPLLGLAASSSPSSLSRIVWTSSSVQLYFSPPVKYVTLEDGDARRKMNVGQLYYQSKFCSVLLLFQVARTSLNDGIVAIVVDPGNIKSDRLQRHLPSIAQRTMNAVLLHSVDLGAITQLYGGTAPEAAQYNGTYLSPWARLGEANKAAYDAEAQAEMGKYREDAVRSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTT9</accession>
    <name>A0A2R6NTT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000839">
        <property type="protein sequence ID" value="PSR76559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTT9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="197" mass="21852" checksum="47AD9974E7172E5B" modified="2018-06-20" version="1">MDQEDTSTGYMQDQDDQSEEVDLSAVDPDALPIFQDCVDVVDQFRQGELDQMEAVRIVVNSLKGSGEVERTALEWFLKQINEISASAGTRESTPAVPYTPCPVPYTPCPVPPPSSPIPPPIPPPIPPPPPSPGPSKEIVGKRKRLGTEIHAGSESVLFPADLRIFQYNPDAVPKKRAKEEEKYHRPQRQRERESEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUL2</accession>
    <name>A0A2R6NUL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000823">
        <property type="protein sequence ID" value="PSR76953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUL2"/>
    <dbReference type="STRING" id="98765.A0A2R6NUL2"/>
    <dbReference type="OrthoDB" id="2766819at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04327">
        <property type="entry name" value="ZnMc_MMP_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="313" mass="34666" checksum="2E2882B8AD0AA0D8" modified="2018-06-20" version="1" fragment="single">MSQPHACAQLFLPAEDSERAIRAALTENPKNATYFSASTPDGVAADAGVGGAPMALALSVRKMWAAGRTLRVSLRGGSETVRSKVKQFAVIWSQHANIHFEFVDQEPAEIRVAFDMNGSSWSYVGTDCLTIAAADPTMNFGWFTDVTPDDEFSRTTIHEFGHAIGCIHEHQQPNARINWDRNFVYNYYAVNSGWSRAQVDSQVFAQYDAVRDNIQSTVFDGTSIMEYPIPPGFTTDGFTVGWNNHLSANDIQFIGTMYPFPPTSLTSLETGSFNTMSIRSWDRPANENVGTINFTIPRPSPPTLLLGINWFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUW5</accession>
    <name>A0A2R6NUW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000808">
        <property type="protein sequence ID" value="PSR77207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUW5"/>
    <dbReference type="STRING" id="98765.A0A2R6NUW5"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35346" checksum="F43784085C1DDBDA" modified="2018-06-20" version="1">MAPPAAVEHMTAHVLQQLTRHRSQFSPDNQPPPLFVAVQGPQGSGKTFLTSRLREALVSDPHSLSVVVLSIDDLYLPHDQLVTLAKANPENRLLNGRGQPGTHDVPLGTRILSQLKRINEADNKDDIVEIPSFDKSLFGGEGDRVNECVTAHGPVDVIIMEGWCVGFYPLTPEEIEPRWELPVQGLGGDFFGSRGFQKANVFDINMKLCTYLPWWEFFDTFIQIKPVENHPYDYIYTWRLQQEHHMKSLNGGKGMTDQQVEAFVDRYIPGYVFFGDGISEGGINENGQHQRPPWIGNGLSIQIGEDRNVLNVGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVD1</accession>
    <name>A0A2R6NVD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000792">
        <property type="protein sequence ID" value="PSR77507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVD1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="5702" checksum="F3747E6983E44F89" modified="2018-06-20" version="1" fragment="single">YLYTTRTGKITWSPIPTESSSSGLSDRNSPIGTSSQPTSVADSVPPKPPSSTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVE6</accession>
    <name>A0A2R6NVE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVE6"/>
    <dbReference type="OrthoDB" id="3264363at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="429" mass="47137" checksum="2CD270394A9EB1E7" modified="2018-06-20" version="1">MKDSRAEHTQPTAIAARQVNNLLNTLRGEQFRHSQNVRRSPAHINIARSAALHSHNKPTLPFSQIFGDTGPEAESDVRPVQPAPFRNPGQAGHRPRQPVTLIEGVPTYAYPNGAVPGPRPPKSWSVLFSGEEKNEPAWRASALSLFLRDLPSSISHAECSTTEQTTIPPLTIHCIRILISLYDTPEDLGEIAQYISPHLRREIMRWCAIYRPMTNGKLYALCGNEGCADGELIVVGPEGTLRMEILKKAKGTGSLSRSPAPEKGGDGEPSTPISQAVLDWDEEVESEDWDVPWPAYAPPPLTALALLATPLSISALFSFPPTLTHLALLAIPQPAPVHRLPHLCPLLEVLDLSLNSWLGDPTESTLDRVEWKRWRQLRVLGLRECGVGPDIARIVNQSRWADVEVVGVVEARSPIMYTAAANNDHRPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVT9</accession>
    <name>A0A2R6NVT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000770">
        <property type="protein sequence ID" value="PSR77859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NVT9"/>
    <dbReference type="OrthoDB" id="2802108at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR77859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="14185" checksum="0EBC7B4E789E7F2C" modified="2018-06-20" version="1">MSLQTSGPDSASVQHSKEGNLVVDGQFVQDLEEDDFPPPQKLTPEQEKKLYRKIDYRLMPILTLMYLCSFLDRGNAKLQGLTTQLNLTGNKYNIALMATSNHSLSWVSLKRASEASKIVLVWLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW47</accession>
    <name>A0A2R6NW47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000758">
        <property type="protein sequence ID" value="PSR78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW47"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015330363" evidence="1">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9056" checksum="9783342618B0A13E" modified="2018-06-20" version="1">MQFRAGYSVLLGVLTLTLRATARPQASTEARALVPNAAAIDGYVLVCTDTNYSGICASVGFTSGACLNFDVFSGLNQFNISKTSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX57</accession>
    <name>A0A2R6NX57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX57"/>
    <dbReference type="STRING" id="98765.A0A2R6NX57"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="33576" checksum="689AB5B32BD740DB" modified="2018-06-20" version="1">MSDIAVGDPELLDEAFSDVDSLFDEPTAIDDAALGLGYVRSNLASYVEPPRPKELRPARRMAPPIPGLYFDPYTLLPDELAETLMQKCIDAYFRNEHVDQVMLFERVITQSITGEGQDEETRYPASSRLPSFLTDLLYTLANTLRPVLPVEVHELLFPPAGSLPQARQVIINLYRPGEGITPHVDLLDRFGDGIIGVSLGSGCAMQFAKPASYPGSTVTKIDEDEKYAVFLPHGSVYVMSEEARYGWTHGIERRKEDWVQDRIGSERGRWVMRSVRVSITFRWLLPGADVVGGSADPVARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX98</accession>
    <name>A0A2R6NX98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX98"/>
    <dbReference type="STRING" id="98765.A0A2R6NX98"/>
    <dbReference type="OrthoDB" id="3028286at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="292" mass="32367" checksum="048A1614A180D3AB" modified="2018-06-20" version="1">MANNTVRLPLRNRTGPQRPKPSADENAVSKHVRQSSVTLNGAASASHSFGNIHALKNIPQRAALGEVTTTAVNRKVRVPFHDTTFAGYCPPDIANNKLTGKGKDTAETTLKRTRSSSLAAATGAQRVPLGPGKVQPNIATQTAVQSRVAGTRIQRPPVKATQRVPAPKAPIVEVEEDEDEDSMEIEDEDAVQNEVNVAEDPTHISSEEVENMVEVESYEELLQPEALTTRTTRIWPELGTTRADRYRKEVDDIRERFQDEADDEDMAMVSEYSDEIFEYMHELEVNDHRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY46</accession>
    <name>A0A2R6NY46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY46"/>
    <dbReference type="STRING" id="98765.A0A2R6NY46"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR79657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49569" checksum="4727465E1083D9EB" modified="2018-06-20" version="1">MSNLYHPFTCYAGQLLDVLNSHFQTVFGITKLQSTLLQLAYFGAYFIFAPFAGMFMDRYGYKKGIHAGLTLYSLGAIFFWPSAKFEKYAGFVGCTFVIGCGLSTLEVAANSYIAVLGSPKFAAARLNFSQGFQGVASFAGPMIASRWFFTGKNATTLDTVQWVYLAVAALGAVLNILFYFCDLPEINQFALAEEMHEVGLKTDDEPFWKQYRCIFGWVAQTAYTGAQVGVASLTVNYIVDQNIGINKSQASQLFSYCQITFTVGRFIGVGLLNYLDPALLLSIYGVMCSAFAMATAFAPGKAGIGCLFTLFFFESICYPVIFTLGTKNLGKHTKKGSGLIVMGVGGGAWYPPAQASIADRNTRLSYVVPFTGYAAMTMYAVGIVIDQTIKGGFRFRTGDEIEERRHELEGSKLASDSTTDEKRSSKESVQQFERVEQAEKLVAYRGLAGDVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY54</accession>
    <name>A0A2R6NY54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v6885</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000681">
        <property type="protein sequence ID" value="PSR79839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY54"/>
    <dbReference type="STRING" id="98765.A0A2R6NY54"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromosome, telomeric region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:DNA repair"/>
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        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUE"/>
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        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
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        </location>
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            <begin position="787"/>
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        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
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        <location>
            <begin position="102"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    <evidence type="ECO:0000256" key="16">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
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            <dbReference type="EMBL" id="PSR79839.1"/>
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            <dbReference type="Proteomes" id="UP000186601"/>
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    <sequence length="991" mass="103728" checksum="290A9CC39702725C" modified="2018-06-20" version="1">MYNSSTYRKPKTSTEPAVSEKFRTQAQQLQELFPSWSYEDLHSVLNEVNGVVEVAVTQISEGHAEQWGSVHRKKDKKPLLSTSQSYSKDFGGNKERGEFRGGRGGRGGRGGLGRGGSARGGFARGGHQETNGRHAKSGPSKPIDAPTSKLIEEVAATDPVIVDVDSPKPADEPEVEAVDAGAVSVSSDPALNTSTPFKWGGETATNGTASCHVQPTLAKVMKTPATSKLSWAQIAKPQEKPLAPSAPVAPSPALPAPSVSAVPAAASSTVPVSAEPIPSHTEPEPEPEPEPASQGWEEPTTVQAPTWDDEPSRQSSESWPQVPEPIASEENKVQAEEVSVPGLQPEPVPERVLSALPAQLQPSTAKVENVQAPAPVKPVTPAAHTRPTSAAHRHKFKTDQAVIMPSGSFGTPLEKVGMQFGSLNLGGDDLEASSHEPAAETSPIRNSESVSQEPPQASQPAQLPALQVQTQASEPSPAPAITSPPTQTPLGGAPGLFQQSIPQQAHHQQISAPAPIPPVSQPQHQSGLSSSLSQPALPAQVSVQPQSSASTSNISSYAHQGTAAPPSLPSHQLPQQQSQSQGLLTQQHQQYVQHGIPTHLDQQPTQPPQVAPATQQNVGGHSSYFRQQEAPYFHTPTPPVSASQTQDGPYGSFGQLSGQLGHQNQASHLGGFGGADYQYGGESQRNFYDSYTGPTGFANRNVLGHDDIKGLPGAPQQPHGAPGLPPSNAQPSQQLPQSSQGGNQAQPVGQGPQQGYPPPLPYYYTPYPQNQYYGSPYSSGYPQQFVKYPTVFQGPPGPQSAPSPAAKQAQSSVQPQSPYGQSLYGQQHSSSPYGDIDYQHSHGQSVGSLPSNDYGKQLYGGGAQGMQGFMGLGQSSGPSSGPPLGQRNSGSPEAAYKPYGGNAKDVGAGVGAGVGQGNQGPQGRGAQQPQGSFYSAQRFSGGAGAGPQGGQSQQHQPQGQGPQGHLGYPQQGGSDGSFYSYQPRQQQGYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY55</accession>
    <name>A0A2R6NY55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000689">
        <property type="protein sequence ID" value="PSR79683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="98765.A0A2R6NY55"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="41"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="155"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR79683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="272" mass="30503" checksum="8CD9E052ADA853B0" modified="2018-06-20" version="1">MSFAPTLVRQSHKLPPSSRKWLQRQFKDPLVRQRASNSLHFRARSAYKLLDLDVKYKFFDYHDVRAVVDLGGAPGGWSQVVASKLGWTVEDVVGSRKLKAKKTEEEFEEFEDGFGLTDTAKSKSYGSWSTPVSDEDDEDDSLNLNKDIPNAKQPKGRGTIVSVDLLPIYPIPGVQTLQMDFLSPQTDRFINALLAEREGYGGVGKADVILSDMAANFTGNRTSDVESSLRICEAVFEFTQRHMRTAREIGRTRGGVLMYVFKSDFLIVNPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYB5</accession>
    <name>A0A2R6NYB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000676">
        <property type="protein sequence ID" value="PSR80006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYB5"/>
    <dbReference type="STRING" id="98765.A0A2R6NYB5"/>
    <dbReference type="OrthoDB" id="3267098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="222" mass="24370" checksum="3E054AB6DAFCE938" modified="2018-06-20" version="1">MGAYQRWFGCDMTAPAGFRPRRLHRIGFVNGNDPFAFGFLDPSQVIRGVHLIPSFAYGMTSEHLGPSIVRPASNNNKDWLLYYVNIFADCNMFMRYLGGGVGHRVIQFLTDFLTAPAVDEDEPIEEPDEICSSGVPQETGAISEPDVNDDDEEDGEDAGQQDDEDGEDDYGYNGMPSHEDDDGSDIDDDDGDADEDDLGPEDGEDEVAEGDKLEEAEGFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZA8</accession>
    <name>A0A2R6NZA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZA8"/>
    <dbReference type="OrthoDB" id="3143642at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6603" checksum="AF722E92AF452AC8" modified="2018-06-20" version="1">MSKAGKSLGTQSPPLEATGEDKPMGISSIDGDTPDAVPDSEQREEYFKDPQPAKDTAPRAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZB4</accession>
    <name>A0A2R6NZB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S5 domain 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZB4"/>
    <dbReference type="STRING" id="98765.A0A2R6NZB4"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR81179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40663" checksum="36E84BA8F6B406DB" modified="2018-06-20" version="1">MFNLLRLHARPATSALQTARRCYATAFVPPASLTEGMTSPLPVKPKVKPDSPTFYTARAGYFDGLTALEDAITDTRRALTALQLLPLPQSVRKALPPLQPVWHTKDTLAGHLSAIVTTSKYRRYIRVLDQLNEYRQIAEIAGVVELAENLADIITSFERENKEAVLAHGKKKPVQFDEYGRSYTLGRRKESTARVWVIPVKTPEAAVSQSALQTESPGELSHFIPQPLTIPTKILPVTTTNIIVNNAPFIEYFPQLTDRERAILPLKIAGLLGAYNVFAIVRGGGTTGQSGALSLGIAKGLAAHVPEVAAILAKAKLLRRDPRMVERKKTGLAKSHKAGVHLRLPRFTLDNEGKTKAGLEYENKPNDSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZD4</accession>
    <name>A0A2R6NZD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZD4"/>
    <dbReference type="STRING" id="98765.A0A2R6NZD4"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="47"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR81167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="294" mass="33444" checksum="66E1744B289D3739" modified="2018-06-20" version="1">MSWAGYVLEFLGNSSIQEIRKPSRHHGGRSSAVLPAFHSLTPAYLQLLQKTGQIERTIDREFAEEESKFKIYEKECQALQKDSKGYLDAMRAMTAAQARLADTIDTFYSASDKSSESAMAAHAYKRGVEDLDTGIGRELDAPYRTTIMEPLGKMNAYFPVVHEHINKRNKKLLDYDAARNRLNKLIAKPSEDPTKLPKAQQEHDDAKEVFDMLNEQLISELPQLLDLRVPFFDPSFEAMIRMQCKFAEEGYEKLSGVQRYFEDNVRDDYAAGQLDAQVENVLQEMRELSICGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZJ3</accession>
    <name>A0A2R6NZJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZJ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NZJ3"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR81324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="33674" checksum="867FF7478A4EC732" modified="2018-06-20" version="1">MPGGRRLLSSSANLWHENPLGLPKRPGSAPQIPRRNAPIQKRPIPNVKKVIAVASGKGGVGKSTVAVNLAFALAMRQSPDQRRLRVGLLDLDIFGPSVPKLMGLETAEEPRLTDEGAIMPITNHGLPCMSMGFLLPRSSPDAQSNTDTAVVWRGLMVQKAVQQLLFDVDWREQGGSGLDVLVLDMPPGTGDVPLTLGQLVVVDGAVIVSTPQDVALSDVRKGVSMFKKISVPITGILLNQSHFICPSCTTPHYLFGSPASFRATASQLGVDVLGELPLVPGVSESSDRGVPYMLTGENKEWLKVLEDAAESVLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZX5</accession>
    <name>A0A2R6NZX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000606">
        <property type="protein sequence ID" value="PSR81824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZX5"/>
    <dbReference type="STRING" id="98765.A0A2R6NZX5"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR81824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="403" mass="44138" checksum="CA4F98CE7B621BAA" modified="2018-06-20" version="1">MHSIRSSSPAIGHTPFSTNIKPPAISAQNHMNATKTMIDFSLAPGVDAVRTWPVSWSSQNIIVFGRGNRVYYKNLQTTTDEIKQLCKVRECSGDLRLLECGGKDMPNIVASCAAQGYVQLWDITTKKTVSQWTTPGGVHSMKWNGPVLTIGGPRGTIKHYDTRISPQAKMKEQAKRVTRHQAPICSLSWNSQGKLLASGDETGLIYCWDTRQNAPLDVGELIQRRRKMQHNGPVHALAWCPWKPELLASGDSAADKSGTIRLWSVNSSSSTNNGYPDKVELDAPITSLHFSPHCKELLSTHGLGKTTPVPQGHDPETLTTIERDPIPSKYSNSAVVHSWPSMRHVVTKSMGTGNVVGSLLSPNGCKVVFAVPEEGKLKVWDVWGKPGGLKRQPSALSIEGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P098</accession>
    <name>A0A2R6P098_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000600">
        <property type="protein sequence ID" value="PSR82081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P098"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="214" mass="23710" checksum="D7443EC8E35CB19C" modified="2018-06-20" version="1">MVVNLRLVLATLGDSARGTAAIGASEYTCMEALATVLEAGPSAQEWDRLYALSLLGVLIAVVTAAKVHQAAETEPDTMACRRLQSQALGVLQTLVSVAAPTDLQYFCNQTILTPSGPSETAFYERCCLQLNCNECVTGEPLRQFFEFMLCITQFPEMRPGRMRVRHEHVSLSMCAVNACRRQLRMGDETHTWGVLNEGFRLIAWVLFSTRIFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0I1</accession>
    <name>A0A2R6P0I1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000589">
        <property type="protein sequence ID" value="PSR82349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0I1"/>
    <dbReference type="STRING" id="98765.A0A2R6P0I1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28366" checksum="3EFCB0336454D3C3" modified="2018-06-20" version="1">MIRTYLLTDYHQVFVKYAESSIKGTLRTGTNITKIGTDSILLESCLFNCPTDRLGSLPIITYTGNGASSASQRCSKLVLAFPPVIHALEAAHLDITPGENAVFSPVGTTKYWSGAVNVATPPGAPLGAVAFEPAGQPSAIIPLFNFSSIATTWSWGKYRSTQTDQEAKQLLISTISKFNKDPNNATQLPIPITEEDVREFKGWDYFPHYDTTQLQEGFYARFNDLQGQRNTFYASGLNGLETVEFAIRAGQDIVNTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0K2</accession>
    <name>A0A2R6P0K2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0K2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="297" mass="33131" checksum="34C75B5AACA4B2F1" modified="2018-06-20" version="1">MELDRKVREFPVPKEVVEILEDLKNPATEDEPPILTRLSEKAHHALAAATNDPAQDGALWNIKIEDDADELEIFAGKTRLVESKRPSPSPVLDTRMEPQPAQSVSRPLYDPMSQPSINPPPTLPTLPHMQQVAGPSGSGSNWPQSQDGNTRVQGYSNVSYSPQRSQDYYLSTGYSPSPTSGQVGYGQWPPPHNQPQQQLQQPQQSQPYMMQQQQQQYAEYGISQYPPNTESYMRHHAPPNLAGQPSHPTHPGGQGPYPPPAELVNLGLASRDSRLGERWTSFMQESGFFDEINYRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0N4</accession>
    <name>A0A2R6P0N4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0N4"/>
    <dbReference type="STRING" id="98765.A0A2R6P0N4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="204" mass="22806" checksum="70FCEC270C974425" modified="2018-06-20" version="1">MSSDNRFMYQSAQEVPTSYAYSQYSQYDTTQYASPPRPVRNGAPAQPPPHSQHYPTPTNGYPPPPGYSGPAYGVTPSQNTPQWSSENWSQFPSPFSQPHPPIQEAQSFPSDSRPEIQSQSSGEPKGPPTGSQKLDNRRKDEQTSRQVEAPHQPKGRKTREDEIPVPPPVPALPSAPLGLDFMKIPQTRWARTLGRVDMHYRLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2G9</accession>
    <name>A0A2R6P2G9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000533">
        <property type="protein sequence ID" value="PSR84473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2G9"/>
    <dbReference type="STRING" id="98765.A0A2R6P2G9"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR84473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="452" mass="49702" checksum="DDE18337398A28B0" modified="2018-06-20" version="1">MARSTEKDSEQAFLLPLRDCPPESGHVSESSPRPNKRSNLRQLLALALLTILTFGGIARDVWMKSHRTEDILPWNPEKAARKVLASSPVIDGHIDLPILVRSYYANNASAFDLHDNMPGHVDIPRLKTGQVGGFFWSAFVACPDWAGYDDGEDFLNSTWRVRDTLEQIDISRILISKYPDTFQQALTTQDIKAAIKKGKIASLIGVEGGHQLGNSIAVMRQFYALGVRYVTLTHTCHNAFADSCGTLPEKWGGLSPLGHSLIDEMNRIGMLVDLSHTSDNTARQALKYSKAPVIWSHSSARAVHTHERNVPDDILAMIGRGEGKKDAVVMVNFAPDFVADPGKADLSAVADHVEHIAAIAGRKHVGLGSDFDGIGSTPEGLEDVSKYPALIVELINRGWKRPELEGLTGKNLLRVMEGAEYVAKHLQETGMAPVYDLYDKRTDLPRRSGSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2S4</accession>
    <name>A0A2R6P2S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2S4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6381" checksum="0D3A6EE5859FF905" modified="2018-06-20" version="1">MSRYCEHRSDTGEGSEPLGAWHEGDIAGPPLRVQGAVSVTGQDHLNLLSVAPSTFKEAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8N1</accession>
    <name>A0A2R6P8N1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000516">
        <property type="protein sequence ID" value="PSR87219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8N1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="353" mass="39341" checksum="36EB0F403D47E3EB" modified="2018-06-20" version="1">MASMFSASLEQEPAVLHELFTLDAFAVLQADVGQSARASSETSLDIFFRSLALWNPFRDLPSRTPTHKMLDLLARILTSYPTVDCLVNFLCTGDSNNIKLVIDHILDAVDCWISSDGSWEPVDDTQSLHYPSNTIHPIWPFLCFAVFLAYKHAGAARLLLASRLCQHLRNLIESSSPISLNPCKPPVDRTKQLIIVACHLLLSAIEHHHALDDSTSNFQLELKSYLDDVLSDSLLPRGYALGFGGPMTWGEADFPAESIPNDCMKDARRTATREQARAALAREAVAALTSNDPGHAATITSKSLMQEASRMKRLNQERMYREQARAVLARHRQYTVAKQSGEFKGDPRLYFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMW4</accession>
    <name>A0A2R6PMW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v4628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMW4"/>
    <dbReference type="STRING" id="98765.A0A2R6PMW4"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="12">
        <location>
            <begin position="188"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR93733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="681" mass="78603" checksum="321A61D59F5463C1" modified="2018-06-20" version="1">MSSAPLDRQTVLDTDPWLEQEVPAILHRHDLFRKWKNTIQTSEGGYDAFTKGYNKFGLHVQSDGSVVYREWAPNAKEAVLTGDFNNWNRISHPMHKDEYGVWEITIPSTASGECGIPHDSKLKISMILPSGERVERLPAWITRVTQDLSVSPVYDARFWNPPKSEIYQFKNKRPPQPKSARIYEAHVGISTHEHRVGTYKEFTRDTLPRIRDLGYNIIQLMAVMEHAYYASFGYQVTSFFAASSRYGSPEDLKELIDTAHGMGITMLLDIVHSHACKNVLDGINQFDGTDHQYFHEGSKGRHELWDSRLFNYGHHEVLRFLLSNLRFWVEEYQFDGFRFDGVTSMMYVHHGIGTGFSGGYHEYFGDSVDLEAVIYLMLANDAMHELFPFCITIAEDVSGMPLLCVPCSKGGIGFDYRLSMAIPDMWIKLLKHKRDDEWDLSNIVHTLTNRRYGEKSIAYAESHDQALVGDKTLAFWMMDKEMYTNMSDLSEYTPIIARGIALHKMIRLLVHSLGGEGYLNFEGNEFGHPEWLDFPREGNGNSFHYARRQWNVVDDPILRYRYLNDFDKAMNHLEEKYGWLGAPQAYVSLKHEVDKVVVYERAGLLFVFNFHPNNSFTDYRVGVEDPGEYHIVLSSDSKRFGGFENVKEDVKFFTTPMEWNGRKNWLQVYIPSRTCIVLAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNT8</accession>
    <name>A0A2R6PNT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hepatocellular carcinoma-associated antigen 59-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNT8"/>
    <dbReference type="STRING" id="98765.A0A2R6PNT8"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR93804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33551" checksum="8D16C9AEF28458BB" modified="2018-06-20" version="1">MIKKRSRPQPRLRQPSVGLEEDPSTEEANDGEQKIDLADLLELRKLRRTREGIDISKLSRGEVKKKKKRPREGEGEEEGGLKPGAGAANEADDEDEEDKEAKARKLLRSNNFTQQTNTLDVDKHMMAYIEENMKLRSGTKDDDKKDTGPADPYAELFRITDRYKLKQDSKEQEEGSVTNSLAMLTAIPEVDLGMDTRLKNIEETEKAKRIVAEERKERKKPTDDEEHLAAARFYRPNMKTKSDADILRDAKLEAMGLPSEEHNHRRQHHERQQMATDELVMERFKKRMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ66</accession>
    <name>A0A2R6PZ66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v4124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000418">
        <property type="protein sequence ID" value="PSR99445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ66"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR99445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="749" mass="83168" checksum="2277F6E61DD54AA8" modified="2018-06-20" version="1">MLEAWQAAGIYDEQIFDEERIIATSAPTRRSTHPQRLVDDIEVMNAGMNINIKDGIILSYGDSLYRGGDAEPKDVDVHKAFCDTLEEEFSAHFADFMKPFDSNPPSNGQLVMDHSGEQFQSADASTFGDSRYIFHDHCTENAKITSCMIANDCQWDLDLKDYSTGPLPAIFRFMLTASPDNDLISNMVDHGWDYMSNMIITDDDTDGDDVGRYLHRNLIENVPGTVSPVKAWFAFAQVPYGGSFALEPVWKFEVEMENNWYEAAVTVHAPYRIVSVVDWVSDSHPLPKKPEAGSGASYNVFKWGLNDPEAGERSIEKEHFDALASPLGWHSIPVSDVSGRVSTVKNTTTTWGNNIIAHENWEGKDAWEDNYRPDAGAQLTFDYIYNPKVTDGSEDAMIEAKKYINASITQLFYTSNLFHDLFYRYGFDEVAGNFQHHNFGRGGKGDDAVIVNAQDGSGFNNANFATPPDGQNGRCRMYLWNTANPYRDGDLEAGIVIHELGHGLSTRLTGGPANSACLVFGEAGGMGEGWGDFLATTIRSTKNYSDYPMGAWAANTPRGIRNFPYSLDTTVNPSTYKTLDKPSYWAVHATGEVWAEMLWVVSHRLIAKHGFSETLFPPAPLSDGTIPEGDFYRPAEYTLSGKRKPLIPKHGNSLMVQLVVNAMKLQPCNPSFFDARDAIINADMVLTGGENLCELWQGFAERGLGPNARVIGRMPWGGGFHIDDFSIPRIHGVNTVTEIRLAQIHEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5D7</accession>
    <name>A0A2R6Q5D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000399">
        <property type="protein sequence ID" value="PSS02209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5D7"/>
    <dbReference type="OrthoDB" id="6511194at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS02209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="82" mass="9457" checksum="ED41778BE318B942" modified="2018-06-20" version="1">MAHYDNDGNVSSSPKGFKVDRGRFKLILFTHNESTFYAYNRRKTKWFHSSAKATPVRKGKGESIIVSDFLTAEWGRLKDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7H9</accession>
    <name>A0A2R6Q7H9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000388">
        <property type="protein sequence ID" value="PSS03334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7H9"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7H9"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="157"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS03334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="461" mass="52137" checksum="76B3221344BDFBEF" modified="2018-06-20" version="1">MPVAAFSFGSFGDIITIVQLVLSIQKALSDSRGSSAECRMLAAYLDDFTRSLDCLKPWLSRALMCDGFTPDSTQPTLDQASLNAILYAIATCERLLTEFKIKISPYEASLVQGGSGKWFLDFKRKIGWMSSMREDAIDLRRNLVAQASRWSTPEALGIYLTDLLDETMFVPIHHCCDQREFDRYLRFLFENRAGRTFVNRGNYDLTSQTTNQLVAQNSWSEFVQPGMAIVMSALVRVSRTDPRICPKCKTLNDNETAARESDEIQCLYCRTIFRVFDHRFEEIVNESEENEGEQAPAARRNTTSNTEPASSNHYSEGPRRQTTEDETQFVRRISVIPLVFVQSSSQVSASTAFSPNDRQTHQANTPTPSHPPIPRSQLLSKPFKCPKPGCTKSYRQANGLKYHMTHGSCNFASPKNLGDRPLNEAELRPYACGIGDCMRRYRTTNGLREYLLVFLHQGAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB61</accession>
    <name>A0A2R6QB61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000378">
        <property type="protein sequence ID" value="PSS05357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB61"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6011" checksum="6DEBBC9E0C10BCDE" modified="2018-06-20" version="1">MVKIGAHICDETGDAKAGDRELRIEATLGLGLGLSKLTQVEEEARDQDWGQSIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBC2</accession>
    <name>A0A2R6QBC2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v3904</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBC2"/>
    <dbReference type="STRING" id="98765.A0A2R6QBC2"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="85"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS05415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="330" mass="36719" checksum="ACA10882B680F495" modified="2018-06-20" version="1">MTDHYHPDLLAPFLALPQGDKIQADLDQLRIWDFDGSSTNQAPGHDSDIYLRPAAIFKDPFRGGNNILVLAECYNNDGTPNRTNYRHHAAKIMEQAKDVQPWFGLEQEYTLFSMDGTPYGWPKGGFPGPQGPYYCGAGAGKVFARDLIEAHYRACLYAGINISGINAEVMPSQWEFQVGPCEGISMGDHLWMARYLLVRIAEQWGIKVSFHPKPLQGDWNGAGCHTNYSTKEMREPGGMKAIEAAIEKLSKRHNEHIAVYGEDNDLRLTGRHETGHIGTFTSGVANRGASIRIPRHVGAQGYGYLEDRRPASNIDPYRVTGIIVETTCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBF9</accession>
    <name>A0A2R6QBF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBF9"/>
    <dbReference type="STRING" id="98765.A0A2R6QBF9"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29062" checksum="C7AA57AFF6F5A7AA" modified="2018-06-20" version="1">MGEFSAILSCAYDYPLTKDEPQPFDITTLVAPDGSITAKFVSFGATMTELWVKDKYGRPRDIILGYDDNTKLLTDPFHPVFNPIVGRNLDAFQGSDDILAHHLHIDSSRVVAVDGDAIPTGEFIDVAGTAYDFRTPERIDYRWNDTAGFCGGGCIGYDNCWIYDHNETSKPGISLWSDLSGIRLDVTTNNPATQVFTAYGLQLLNMSRKLVHGGPRLIYESSAGVAIEQEGYIDAINTPEWGVDQICTAGPGTRLRLVTRIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBG0</accession>
    <name>A0A2R6QBG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBG0"/>
    <dbReference type="STRING" id="98765.A0A2R6QBG0"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="8095" checksum="B4E84894EBEDCF37" modified="2018-06-20" version="1">MTELWVKDKFGKARDIIIGYDDNSVFILIYKLGTFSIPITKDPQPDGPNVFHIPTNDHDGRTILSIIYNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEE4</accession>
    <name>A0A2R6QEE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000363">
        <property type="protein sequence ID" value="PSS06514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEE4"/>
    <dbReference type="STRING" id="98765.A0A2R6QEE4"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015213027" description="Hydrophobin" evidence="6">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS06514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="143" mass="14712" checksum="2B12A2F23B0549E6" modified="2018-06-20" version="1">MFARISATSLYVFIALGVLGVATPNPENAKRWGAPASSVASARQSNTGALECCQSVQSVSPEYSKLNCQSLTRCENQSSTQQVKLILGLLGIVLQGPSVLVGLTCSPISVVGPGAGQCNASPVFCNDNSHVSLAPPASAVVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEI4</accession>
    <name>A0A2R6QEI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEI4"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015333224" evidence="1">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="7809" checksum="C27285D92E162624" modified="2018-06-20" version="1">MISGPDLWQIVLLLLNAQAYVGVNGHTPVLAQTPLSGQSWDILFSGYLVVRDGFKPGMGNNVIGALDILRMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEQ1</accession>
    <name>A0A2R6QEQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEQ1"/>
    <dbReference type="OrthoDB" id="2987506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="454" mass="48888" checksum="AA4316AC0C698F35" modified="2018-06-20" version="1">MSTYNLDISVNIADIPILKNGGYRLCIAKRVNGKYDVVWSGGAFIASNSFAWDAEFQVFGALKFQGGFQVKAGTNPEELKFGQSVVLDSNGVMQPATGPTDKSGVFKVQNNYGAMCIGVNAKLGGAWSPIYLSQTPFASGVVSLTPIEKVLVWFDALSSTGTMLVDAVTNSIELDFTGKTSQSVTYASDPNKPGNGGWIVGGSAVLSSTYHVDTDTFSLETPSAPLLGKLSTLINSQNSLPLSKLAVSASLEFYDEVSAEEFVRYAFGKRPEGVRNWDFVQTSTVVELKLQTEKDQEDELAVKFLQDAYLGVLYSFPGPEYMKLTFQILNRHSLPTSAETNVAPAAPNVVDPRSSGELRIIYSSASQAADAAKGITALAGNGLAYVADVHSDDKQWVRVLLSLTFPSGNVDQDRHAIVDPLATALFGGGQYFKQPPLFPNTPDFVMYAVQWGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QER5</accession>
    <name>A0A2R6QER5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QER5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14053" checksum="BBCECF59A76DA531" modified="2018-06-20" version="1">MHSVLLAINITNVILNTVPSLRDVSPAFTIIEVLTPILISRFLLNLRQLGEPENESQSRFNSRVSIPGFRVPTLESIVGNMGADLDHGPAEDSEPEVDEVAEDVDIDGGDVEVAVLDVASEDGSGGFINEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QER6</accession>
    <name>A0A2R6QER6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3624</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QER6"/>
    <dbReference type="STRING" id="98765.A0A2R6QER6"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="482"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="534"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="621"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="850"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="920"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS06566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1010" mass="113192" checksum="DE65BC89405C711E" modified="2018-06-20" version="1">MQTENSSNMGGDSDDDFDWEEVEVPVSNVDENTLATDYDVEEGLSATVKPNIEITLHARPKKDDAEKKRRAALYAERVSRLNCHKVHTVVLLGNARIRNNWLNDPLLHARLMSLTPLTIQNTFSVIHKSRIPEAVRRGRMFEYALNQLADWWYKTFTVEPTGHIRNRTYTEVQEVLAARSDLKGKRRAKDEDEDEDEEEVIRSEKSLMKHALMRRGSRDTSAQLFTALCRALGLPARLVVSLQSVPWQAGVGKPKPSAKKKGDKKGKAKATEDDENEDDDMEMEEIAILSSPALSGKEKATGSETFPGGGQRLDGSNTPNTDKGKGKQKAAPVITLRKSRGQKLGSAAKKPVKRERTPDPTETAPVFWTEVFSRADARWLPVDPIRNIVNKRKAFDPDSKFSTLPGTRVENRMVYVVALEEDGYARDVTPRYATEYGAKVSKMRQGGKGKREWWERVMAMVQRPYRLNRDDLEDEELHINQITEQMPTTMSGFKDHPLYVLARHLKRDEVIHPPVELGKFRGEPVYPRSSVVPLKTAENWMRQGRKVREGCQPMKWVKQRAVTVNKQRAVEMAMTDHENRMSASGSDQGEGFSSEKDVMQGLYACSQTEIYKPEPVINGKVPKNDFGNIDLYVPSMLPAGAVYIPYKGASKVARQLGFDYAEAVTGFEFRKRRAIPIISGVVIAAENKDAVLEAYHAAEQEAEHRRRTKRQEQVLKRWQRLVHGLRIRHRLQQQYADRDPPQPARNNLVVEVEAGGFLETADDVVQPYTLPRNLHDEPKSPTAGLSEIYPVKILHGDSKQTADETLTGVVSFDNDESQASEDLPEEASMHEPSGSVEYGYDPKSNVVPKSMRELAEEAERALEEAVVHHSLDGAEYRPSPPPEAQNEKTTGPVNGHVISTGHTRGSRSKTSTPSTAKTSNRGSTPKVTLKVTTRQGRKRAREDNVSDSDADKSGAISPSKASPVKRSRASKPSTPAVKSDRVLRTRAPKNAGKLQEEREQDEAYKRAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QMB6</accession>
    <name>A0A2R6QMB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pheromone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QMB6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000772">
        <property type="term" value="F:mating pheromone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012597">
        <property type="entry name" value="Pheromone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08015">
        <property type="entry name" value="Pheromone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS11044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="6862" checksum="F56A8109245712A8" modified="2018-06-20" version="1">MDTFDLINLLPILAGGDSPSSMHPQSSDSPLPTSFLVDDPTISDLILVDLEHSGGSVSKFFCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0X1</accession>
    <name>A0A2R6R0X1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000286">
        <property type="protein sequence ID" value="PSS18892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0X1"/>
    <dbReference type="OrthoDB" id="2683861at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="11188" checksum="D654E4642D969F14" modified="2018-06-20" version="1">MPNQWLDWWCAIQPSPRRTEPVSFEIDLDHPKNLAPQCWAPISKSGPQGISNIVYALGLSYPSAKRQAHDTRTMSERQWHRWVCDVAWVFTQLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHX4</accession>
    <name>A0A2R6RHX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dimeric alpha-beta barrel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHX4"/>
    <dbReference type="STRING" id="98765.A0A2R6RHX4"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26815" checksum="AD079E2519E89078" modified="2018-06-20" version="1">MAPPAYLLVFSDHGTGVSEEEFTDWYDNEHVPLRVAVPAFQTLTRWVAADGKSPHWGASYDLTSYEATQNPPYNTLVATRSEREKRIVQEAEILDRRTYELWEGPLPSPSALFDKTKSAPFTVFVSIDVKPEAEDDYNKWYDEEHIPLLSKVPGWIRSRRFILKDSGKLGVVGKTDQSPAPKYLAVHEWASLDGKDSEEYKHAVSTPWRERVVKDVVAYERRVFKFYKSWEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHY0</accession>
    <name>A0A2R6RHY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHY0"/>
    <dbReference type="STRING" id="98765.A0A2R6RHY0"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="5">
        <location>
            <begin position="319"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="777"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="934"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="896"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS29636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1063" mass="120763" checksum="177DB95E19016E0D" modified="2018-06-20" version="1">MADENDAIAALTGFTLDNVLSGLDLPTGPGLSNQLGISGVSGFSSTQIYNDKWDDQDAIGPGEGEDWEDEVDRELEEEEDDGAPVKIEMESPRMGKKEKRKRVIRRLVERPRTVYERFPTFERDKVLDFTELFKGYTVQKSRISKRPFYVEPVVYTRKKEAPKGFLEALVGEAEREVEHQRVEQVVASGSIEQDLRHALEERAKSNVPISLPLHDRSFDLVLLSNWEDQIIYEPAMDVNGRTDDWDPSRMLGNDLTAPLNEGLESGAWTQSIIWSPRAPFRDFTKVVQNEEELPEERPADSVRPKKRLRTDNAPPRDRFNLSNDQFYEVTKDGGRHRVRQTFGQLVVEHAYPAQKLQLPFFKTRLSKQEARSFHRPALQFPSNIELRFSKVRTAKKKKDKAGRKVGKGGNVGEGLHKTGDLSLRDTSNFVLWELSEEHPPIISNFGMGSILVNYYRKKNDKDDHIPKYDLGEPIVIEPQDESPFMKFGYVYPGQTIPALYNNLMRAPLFRHKPYPTDFLVIKSTVKNDTKYFIREIKNLFAVGQTYPVTEVPGPHSRKITNTIKHRLQIIAYKLLSKSAEERLKISRLMKYFPDQNELQMRQRLKEFMEYHRRGPHQGFWRLKTNWVVPPETEQLKLVTPEQVVLSESMQVGQRHLQDSGYSYNGEVAEGDEDNLSVEQQLAPWITTKNFLFATQAKAMLRLHGEGDPSGRGEAFSFIRVSMKDIFVKAGEDYEKKLAEAESRPKSAHRYNVAEQQVIYKSEIERIWKAQFDSLSRKDEPELTKEEEEAAKDEPKKTGRRESMAQHSAAGYTPAQSPVRHTPGPTSPTFSRGSSLAREQDLVADQRKVLRIKRLVNGEWKTEIIRDVAVINAYVKKRQTMEEENTTADALAPTGDAEKDKRAKKRLEEEIARMKKNQERRLHRKNAKIVKEGGTPMQLNRPVKPDTTRRCGHCGQMGHMKTNRKCPRWAEFNSGAPPPTPSTSAASPPATSPTEFGKGSESLFSPGASSNSLRPPGTLLAHGPSPLAMSPPVTAMDEDDDDDGDFPPPTPSAAPKIKLTLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI45</accession>
    <name>A0A2R6RI45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2806</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI45"/>
    <dbReference type="STRING" id="98765.A0A2R6RI45"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS29658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="290" mass="31675" checksum="5D7E7F34429DBE4B" modified="2018-06-20" version="1">MATDPSKVSARLSTLNNSLDELEATLEPLFSQTLPESVVGLEKIQQAKLQVALPYVLYDLVFIYLKTRGIDPKAHPVIAELDRVRQYFDKIKDAEDPAKRRLAVDKGVANRFIKHAIAQVQFGRPPGQDEGASQNAGVRVPVKVTSKMTARAQHQQEVKELGSEEEDDLEVFGDEKSTSESSTPNAGKGKARAVEIDDEVCAGQKRRRPVVDPFAGYGDEESSQGRMSKIPKSSSNSRENSNTPGDIAMTDVTRSSTPQSASESTAKAKKQAAKNARKKAKRRETANPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI54</accession>
    <name>A0A2R6RI54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7223 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI54"/>
    <dbReference type="STRING" id="98765.A0A2R6RI54"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7223" evidence="1">
        <location>
            <begin position="168"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="382" mass="39845" checksum="139F63501FE7D2F1" modified="2018-06-20" version="1">MPFARVAKEWTDQNQSIPSPIKAKLTRRATNPPSVRGISLDMNWAAISPSQNGNVSLTVQGSTNTGSGANVAARSSEARGLFGNLVSDVENASSFNVSKSNEKTISLDKSFTVFDQSLSCPASGASPAFTGEIKVDVEPKVQAVIDYGVAASGSIVPPKLDSFGLFANFNATLEGILNIDATASASIDSGKITVFQIGLPGLDFPGILTLGPSFNVDVQAMGNFDTDLNMVVDLAYNISNAKLFFPPGQYYSSGDFAPANTNLQLSASPNVASQALVEAHIIPTVQFGLNALDGLAEANVNLDLDTSAKLMLSLQAGAKASTSTYGKSSATGSFSGCVDLSSTLAVNAGADGSFFDLFDKSTSVTLFQKTFDLFHVCDVRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIE5</accession>
    <name>A0A2R6RIE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIE5"/>
    <dbReference type="STRING" id="98765.A0A2R6RIE5"/>
    <dbReference type="OrthoDB" id="2522283at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="390" mass="42407" checksum="6ABB500CDF1FCBA8" modified="2018-06-20" version="1">MPHIPIEIVISILEIASYQDADVQDNHLLSNCALVCRDWSFISQRLLFRDVSLHTESAFESFQTAVNRSTPKGCMLGDAVERLHCAVDDRQPCGLSQEAFSQAVVMCPKLAKLSLALYGDRTQCQVDAPAVVERSVLPTSSLDESTLSMLRYAPRVTSLQFDNSTDNSEILPQLLEIWPNLTALTISGIAPTLSSPSPAPFPCALEKLRVNCQASPSTGFLTWLLHNSTNTLRVLEFERDLSVEVLERLVANHGASLESITLPSCASPERAALLAQCTQLRDMRIASAGTLPTVYRALPRTLEHLVIAVGKDVVLQPIVQAVKRSEALTKVTVHVCAGGEKHPQLAAMKIACAAKGIELNVTKDTRMLRSATHGSLVPAVFLPCAKPLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIH6</accession>
    <name>A0A2R6RIH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000254">
        <property type="protein sequence ID" value="PSS29814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIH6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="66" mass="7549" checksum="FC64537664A2E7A8" modified="2018-06-20" version="1">MEVRERRRALVGIREPTYALVKVRERRRALVGIREPACILVEVLKPKGALIEARGPKYVLVTAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIN8</accession>
    <name>A0A2R6RIN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000244">
        <property type="protein sequence ID" value="PSS29896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIN8"/>
    <dbReference type="OrthoDB" id="2745353at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="182" mass="21097" checksum="F2385F34DBFA99C8" modified="2018-06-20" version="1">MISAKESGEEAFWHKHCYTVPLGNESAKQKSEKPRKLQTCARCHKIKYAGGVGSGKYHRKLYCSDGVKMQDKADTPSRWPQPEGIFTTRSHFHPLVFLEELRRLYEKAVIQGDSSFDNMKSELFMEMLKARLETMELEKDSQMVKTVVFRLFPYLTMSLPLKDTIAIKDRKQYLRVDCLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLJ5</accession>
    <name>A0A2R6RLJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000234">
        <property type="protein sequence ID" value="PSS30901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLJ5"/>
    <dbReference type="STRING" id="98765.A0A2R6RLJ5"/>
    <dbReference type="OrthoDB" id="4743193at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="121"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="486" mass="55070" checksum="243A1474AD4D4F97" modified="2018-06-20" version="1">MGTTISLNAIHDSIRSLSNESREEILKLGQTLTAAYAFDNFDVDLKPSVPTIEKSSDTLKHLTSGLLFLLSHIISPHDLRCSAELWKKSQLNDESDNLPEDLAPLPDWQNLLRIHPKHSELDSHGMSSRDRWNAWKFLHDLCHHGPEYFAQFRAILDEPEVIEEVPLVKTKLVPARAMDINNGTVDGNRDAIQTLLAQGGIGDPNDAEEGGEEDVVNATEHVVLFHGDLGSGEKIHSAQLRRMLERMPHRRLQSSIFVFGLFHLKMACADGIWRIFIKPKAARNDSTCIMRHVAFLRSREMGTVISQPGFRRMHEIIMHDGICMRLECWRVLVNKKDERILSLQAYAASGPTFSNLQVLADILALEYVARQPDLRELREKTAGQRDKQFENGVIANQYFLLYEELSRAMDSGDIGRVELTFAPWAFIFKGTGKHKYAAQMFKHITDVHMFYPEGLKLAVRYSMLVNPSGKAGCFRATDWCVELANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLT8</accession>
    <name>A0A2R6RLT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000230">
        <property type="protein sequence ID" value="PSS30969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLT8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5661" checksum="123672A5D936B165" modified="2018-06-20" version="1">MPTIRGERAFSGSELEHQHQGIEQNLNPSLRALLTPTQILREDEGPYRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLT9</accession>
    <name>A0A2R6RLT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000229">
        <property type="protein sequence ID" value="PSS30988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLT9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5537" checksum="A3C5363F222D5F8D" modified="2018-06-20" version="1">MLVVLVVDKTSDSHRDNFISAKVLNHEYLPGPSRAILYGKLGTARQARQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQD0</accession>
    <name>A0A2R6RQD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000184">
        <property type="protein sequence ID" value="PSS32217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQD0"/>
    <dbReference type="STRING" id="98765.A0A2R6RQD0"/>
    <dbReference type="OrthoDB" id="2795833at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42857" checksum="C67BC5D94CC8DE98" modified="2018-06-20" version="1">MGLKANKKYMPHLIAALRSRFELSEGGQIHYLLGMHITRDREKRTISFSQSAYINRILTRYRFDEIRTVTTPMDPNVALSKEQCATSERQQEEMKNKPYREALGALMYASVGTRPDITYTVSTLAKFSQNPGPTHWTALKRVFAYLHGTQHYTLTLGGISSPILTRYCDSDGMSNPDRHPIAAYVFTIGGAISWSSKRQDIVCLSTTEAEYIALTHAAKEAIWLHHLLDKVFPKQFKLPITVYSDNQGAIALSKDDRFHTRTKHIDIHFRFVWQYVEDGTLNITYLPTDRMLADALTKALAGPQLTKLAGAIGLQTYNNQHNPPETYPLRLLIIAVLAAATFKLLREKTTPSPSNVQLYRTGYLTRLGNQLVAQQLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQG3</accession>
    <name>A0A2R6RQG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000179">
        <property type="protein sequence ID" value="PSS32229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQG3"/>
    <dbReference type="OrthoDB" id="2753849at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="243" mass="26729" checksum="CA3454D62FC349B8" modified="2018-06-20" version="1">MAKEMDTRHLVVYCKSISVDWVYHMGRCTLYFIIFSALRVFALWDRNIPMTLLVLALNLVPVATDIIRYLARFAMISSTTLPASILIELGTRIALIVGDALVLAVTWVKTARNLAEGARIGMRTPLSTMLLRDGTIYFALQPILISRFLLNLRQVGSPEIDSQEAFNSQFSVPGFRVPSLASIVGNMGNDLEHGDLAEEVDDEVENTSGSIQAEEGAVPEAIIETHFSSMNPTPSTSRLADIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVF5</accession>
    <name>A0A2R6RVF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVF5"/>
    <dbReference type="STRING" id="98765.A0A2R6RVF5"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1099" mass="118736" checksum="44B8033DE8DAC358" modified="2018-06-20" version="1">MALPSRPEPMNATSHHPKVRTTLRFADPLFVAGGAVSGKMEVECRTEKELGVGVIMVELFAIEELTSRDHSATQTFLHTRRIFQGPGLPPSNSVHPHPLPGESLLPAHYHHARRGTTTFWFRLPLPKSSPSAIDFGSGLAQLRYEVRATVGVIWKGQKQLVTDRQQVDVVESFCEDIARNPPEGVAVGENGKIWLQGRVMGDFVVAGQPVWIEVMVKNHSTKKNTGLSISLIRDLRLPGFQSTQKQPLQVTDTLTFESFRGADHTILPGTEAAATIMLNVPEHARTVKGGRREGDEETGRSSECLFQVRCVFIVKLVMGFGSKDVELELPVSVLDPAALPEDYIGVPMDSDYVVANVPPHHALPISTIPYVNPSSPSYDYSLSASPPILPFVDQGQVWLPSPSATPLHYPPLSASLSQQPYLYPSLAVGPPVYATPHRPSSAQPVPSQSLYLDGTTFPPLSMHHHLLPPVSETQQSAELSPEREEGKGERASRIAQHLRMTSRHRSVSPPSHRYQVSTSHAVPVMYAETTEQPRQLSLSPASPGLLVAEHILQDSLSPEAGEVVSPRPLLSPKQSFSVDPFTHTTFSKSERVEALERMAAETVQANANMSNSVPDISLDKDKTLPAPPVPSSKTKPVDIRPKINSLFPLSADEGVTPPTPTIAALSPKASRGFSGLDALEARLLFDVGTRKAKLEEKKHDGPSIQPITIPRPTDVQNLPIDSAISSLSLPGLGAEEGTLRLGEANSSPATSQRAGDFKAAHKPALERPSESSKTHEARVRKKSGPRSRHSAKEQEQFQRLRKAAEGRVAAWLGSIDPEIPPSTTTPPQDDHLPLKPEPNITASLEKEAIPETSLKVAEREHSSEARVGTSPGTRSSGFRLLKANNEASSTTSAHDVTAKPAKDAGADRNIKRKQLPAFLPLPADPEVHYDVRSARGGRGGKVTAVAALWASAAQKPSDLSPSPSARSTPRPQLAKPVVSKKINTNASPLTTSANTAEVKKPADRPSPLPQEAAQETNHRRPRTKATSLPAIMSSSLATPMLSSTASLAKPPPALGDRIRLQNKLPPTISESSAPPKVPPKTEMAFGQARLRELIKKYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVS8</accession>
    <name>A0A2R6RVS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000150">
        <property type="protein sequence ID" value="PSS34134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVS8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="9132" checksum="9D86557611022A8D" modified="2018-06-20" version="1">MAMPQADLSQTSLLYHGLGQEPPSIHTNIQGSNVRCAQCWSPDGLCWLCLPDQMNKEPRVGGYRRLGSGHKQIPYMFSKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW43</accession>
    <name>A0A2R6RW43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000140">
        <property type="protein sequence ID" value="PSS34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW43"/>
    <dbReference type="STRING" id="98765.A0A2R6RW43"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13318" checksum="AF53742CF003BCC8" modified="2018-06-20" version="1">MTGKTRSALQDVVTREYTIHLHKRVHGRSFKKRAPHAVKSVVEFAQKAMGTADVRVDPKLNQALWARGIKSVPHRIRVKLERKRNDEEGAKEKLFTYASHVIVDSFKGLETTVVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZK6</accession>
    <name>A0A2R6RZK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZK6"/>
    <dbReference type="OrthoDB" id="3260925at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="157" mass="17170" checksum="B04251B1276382BC" modified="2018-06-20" version="1">MPPPLPQQRNQAPLSPMSSPHSSSSRLQPPPFARRQSSRNTRLHLPQRQEDPPIPPRLVGSPLLNNLISSNKPIVRNDRVQQPEVWIDGDEFGTHRSRSNPSGADVRRSAQSAGTSIPPPPPGFAVSPTYSRCDIIEAHGVSILLTVLRYSSRGVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3Y4</accession>
    <name>A0A2R6S3Y4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS36997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3Y4"/>
    <dbReference type="STRING" id="98765.A0A2R6S3Y4"/>
    <dbReference type="OrthoDB" id="3218226at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="251" mass="28790" checksum="19AB5BF3FB46CD42" modified="2018-06-20" version="1">MSTTYHPQTDGQTERVNQALEQYLCCYINYQKDDWSRLLSSAEFAYNNAAHEGTKETPFLEYGQHPRADPMLTKENRQQAQEQAKAALKLAAEQMKWYYDQGVQKVPFKVGDKVLLDLRDYQTTGRKLNAWYSGPYEIIEKLSPVTFKVKWPVRMTRIHPVFHASKLIPYNNAKISGQKGPTAEPITVEGHEKWDVEKFSPHGFTADNFNTLSAGNIADLMKTHGNQPAFSKIPKKQFRNITRLIPRPSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S407</accession>
    <name>A0A2R6S407_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v1201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S407"/>
    <dbReference type="STRING" id="98765.A0A2R6S407"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS36985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="332" mass="38096" checksum="41ACC0AF10FBA793" modified="2018-06-20" version="1">MADTATEIDLDSVIDRLLEVRGNRPGKPVQLQEYEIKYLCTKAREIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFVLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRHLVTLFSAPNYCGEFDNAGAMMSVDETLLCSFQILKPAEKKAKYPYGGVNMGRPVTPPRKQKKKDASKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4K1</accession>
    <name>A0A2R6S4K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000072">
        <property type="protein sequence ID" value="PSS37217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4K1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5896" checksum="6F674A9E4F73FDD4" modified="2018-06-20" version="1">MDTYLQVVVLMPHAIQCWMFSLRRVARTERKRVALISERFDFQGPEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4T6</accession>
    <name>A0A2R6S4T6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000059">
        <property type="protein sequence ID" value="PSS37307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4T6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="26562" checksum="645FB0E07EC1A172" modified="2018-06-20" version="1" fragment="single">KSMAGCGWGRRRRRAKAAKADAEVAPQKSIQTVTAKKATAHHGQIDVNPSASMEGSGTGIPRASDAKARRARHVGSMSLDEKLRLLEEVAAALNKDQKINRMYLPASHHGSGTGSYSRGSGAHRHSSVPPSTPEEGSDSSDIEMFNSDEVFNADEIDDPMEMTPTEVYDSDTDMVPPATDLKRCHAMAVVVHVEDVNSNGPEQTKEPEPEPEVVPATSVPDKGNGQKRNQDEDAEMEGGGIPPVASTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5F7</accession>
    <name>A0A2R6S5F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000040">
        <property type="protein sequence ID" value="PSS37518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5F7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5F7"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="469" mass="51764" checksum="26E760D736696F86" modified="2018-06-20" version="1">MEALLSKYPDQIPWLERHGFSVQDLIESLKWYPAQQLGEMESAPPEEREGRYATLEEVSEENFDRLEANLVKVLPPYQDYVSTLSQKLQHHDPEVSLAVRLGGASSVPAEGKDAEDGLDEFLSSHGFEYVDGDRDGAGYLDEDSSGVPGLPRVIDALSTIMWPSLVQSAATSARKSRARELLDWARVEEADDGLRALISSNDDKEHEVGSSGADAAPKKSRMQREMDELEKWLEEDDIGRRRMDDAQAWIARDDATDGWSDIPTPMIRTPGGDQTFFGFDDDFSEFVGAPMDVTYGHEAVRQKPMQTGASYRTLASEFEVGDDVFGEDGDLDLPSHAEIEATSKLIFGTALDVPTNIRTPFRSPSMNSDPLPGPATSNRGASPGEHDTPAYHPLDDDSFSTDHELDDDDDFELSAFDLSRVLGALQGMKEEIAGMQDEGERRKAAARVALGLVHALRKENDRELEAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5G0</accession>
    <name>A0A2R6S5G0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v699</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5G0"/>
    <dbReference type="STRING" id="98765.A0A2R6S5G0"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015350448" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="130"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS37492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="330" mass="36131" checksum="A3672EF3BAF96CC0" modified="2018-06-20" version="1">MRLSFGLFAAVVSLGGTLASNVIDLTPDNFDSVIGQGKPALVEFFAPWCGHCKKLAPTYEELADVFSHAKDKVIVAKVDADGEGKPLGQRFGVTGFPTLKWFGPDGVPEAYEGGRELNDLAGFITAKSGAKSKIKPPAPPAFKILDAHTFDDVVLDPSKDVLVTFTAPWCGHCKSLKPIYEKVALDFANEPNCVVANVDADAAANRPLAEKYGVGSFPTIKFFSKDNKDEPLAYESERTEEAFVKFLNRACGTHRAPGGLLNDFAGRNPEFDSMASRFIVATGSARDTLYKDAELFAKAFGQKYKYYLRVMEKMMNSTEDYVEKESTRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5I4</accession>
    <name>A0A2R6S5I4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000040">
        <property type="protein sequence ID" value="PSS37515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5I4"/>
    <dbReference type="STRING" id="98765.A0A2R6S5I4"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="256" mass="28177" checksum="285BC482F3AD6A08" modified="2018-06-20" version="1">MAEASRCLGDSRGPMLAPHPSRLRSNSSPIRPQGAHPESTLSSEIQPASSTSPQKPSELPRTRSGSISFFAAPSQSSGGIRKSKLFRLKRPSSSSAALQPNYRRDLVAEPPSTTPPRPPRNPARATPVARPSSSSGVPSAQRKLQRVRSLSTTSHSRESSPHRGFGPILESGSDFVLQRKKSRTSKVKLPQNISRVQESPAEIQFSTTDRTILEELKRKMEARDAQFVVKNGKRHHPHPSSEVPYPRSHERHIVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5K9</accession>
    <name>A0A2R6S5K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5K9"/>
    <dbReference type="STRING" id="98765.A0A2R6S5K9"/>
    <dbReference type="OrthoDB" id="5595612at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1092" mass="116563" checksum="17197158B8CF7749" modified="2018-06-20" version="1">MAEPPAYQLEPGTPTHRSRPSIITNASAFADSTMSYGSIMSGDGLARLSQFPSPPSSVPFGSFEGLSPVKSDYAMDPSTATRRALPTPPSLPPAPLNIQKRPTGVSFPNALPSSPSLRQPVDSRLNNTATPSLSRAPTLTTASLSRAPTLTTASTISSYPSPHDWHDGSSSIAADPYGEAVLSTSFITSLLSSVAERDVISGSPTAFTQPKRYYEPSMASQAFTIDSAVTYPPPNTFPPPMPPSQSNPQLWNTQNTSSVTPSHLQPLRAPVHSYRPMGGRATPETTTTYDSGDRTVQTADMAQPGPSTEQMSIVASLQSLNSTTPLIQSFPRGDPILEEDERLSGPSTPGTRHSRTRSRRVSVAYSSKTTKSYVSSFVTRIPHPTGTELKSLRQATVSWFRGKPLPPVPPVPGIPFRDIQRQEAALPLPELVNRAQALSRLLDSGHHPHHSTISLEHAHGNAHPPPGPVSGFGDRVRYTGANPNMSNYAYGRKGRSEEYSHNAWSLTEPPATPESPLKSRKFSLSRLSKRQKLWGGITLLLVIIGAITGIAVGVTVGKDKASHVVCEGNSTGAACNLDATCVCTSTVTGQCGQLAQTLVDLVPNLNSLFNANFTPATLSTAVWEAQGAPSSSNCAQQAILVDVAPALDSVASPNRTLWAQSALLWNLAESVDLNGTAHLQQFVLDADWHTLVPTDGPTTTSASQFSTTISGYEFNFAAQTVVAPPATFETEGQPSQAQIDQVDDSTKTALDRMYTYASASSTQQKQALSQYWTGVLQQKSSDLNTFVSTIRGAPILLPFDATNESLANLLTNPSTSPFPPPLACYPGLSSDQLQKINSIETSIFGLPPAQAQTTFDTSCFASRPIYGTLNILQLRLPFLDGRQGAAKQAAVLQPDAYSRAIIYSGEVLSAMPGSSSPNPPVSDPRRYGTLNNLNHVLLQYLKSISDVNDAIALVEFVLGQTPPIVPPGDTTLLYTALSSLPSLEIAILGSVGPSDISSTVSSFSDPSGKLFFGSTDSLDLRTWTINTNQAPHTVAWAELATSPEVVRDDSLTDDTFNTIWNSSFTFFHTNNTANVQVSNITTGFQALGLFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S622</accession>
    <name>A0A2R6S622_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v398</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S622"/>
    <dbReference type="STRING" id="98765.A0A2R6S622"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_bL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS37705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="13433" checksum="6354F07D8BC372BD" modified="2018-06-20" version="1">MASLALPVARSTFLGARMPMGRALFTSILPTFLTGWTLPQIFEELILRAVPKKKTSHSRKSMRSANKGLKDKRHLVLCPACGSPKLAHHLCANCYSSLNRSWKAKSKQEGGSYSGVPSVSMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6N0</accession>
    <name>A0A2R6S6N0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000018">
        <property type="protein sequence ID" value="PSS37915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6N0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="5985" checksum="12F8459FF5D3F463" modified="2018-06-20" version="1">MSPAGAPGSIPIPKFGPWRAEMLGARTPEKPVAGRKVRYDHPENLGFRQHKAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7A2</accession>
    <name>A0A2R6S7A2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000001">
        <property type="protein sequence ID" value="PSS38145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7A2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="23101" checksum="9AFEEBF4D2DD8FC0" modified="2018-06-20" version="1">MGNTKRIVADDKDVQAIENLLTYVSATLLYFAPPQFEHNHLYVQGTLLSPLRKLETLYLTIGTVEPTTDWLDTTHLLRSTIPTLRTVLLDVQVDLGTQRETKWYFEEAASCITHLEDILLALAASGSLNRVILYLTDRYNSAMKRPFRKVIFHFGKIFPRLRKQGIVECVRLKRTSQLRSQPRHRISVWWSLRLAFMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDP2</accession>
    <name>A0A2R6NDP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDP2"/>
    <dbReference type="OrthoDB" id="3358048at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6998" checksum="8974645784CFEB42" modified="2018-06-20" version="1">MTLRQRIPFKFPAEGEEDDGHIMDEQEQEEVIHQLKIQSDSQNAQYNFLLQIVIALSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE72</accession>
    <name>A0A2R6NE72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001337">
        <property type="protein sequence ID" value="PSR70663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE72"/>
    <dbReference type="STRING" id="98765.A0A2R6NE72"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="333" mass="36096" checksum="D88BBE93C7197F5C" modified="2018-06-20" version="1">MPHRVDSGDRNAQGRPDERAQYEHPGSHPSPPPIATLHSSPAPSAENSSLTSPSPPLSQPGYYQGSAQNGPGMHPGSYTYAPAPHARYPADPASAHQMQSHYPPSSHYQPQQSAQVSTRSIRPTFVPSHPLPQQPAYIVHTDDAATKLNDRVRRKCYNCRTTDTSTWRRSSLAPGKVLCNKCGLFERTHSRPRPEQFPHKRGPIVTTTFKSSRSPPPPQASRLPPIQQQMSLPPHHYDHPSIAPLLPRSDSQGSYGSNGSNSLPEIRNLLNSPQQSGAAQQAASQQQPSSANGDANSLKRPHSPASPSARSPRADRSPPYMYRTNSVAATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEE8</accession>
    <name>A0A2R6NEE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEE8"/>
    <dbReference type="STRING" id="98765.A0A2R6NEE8"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="756" mass="78258" checksum="F560E4AA1FB14EBB" modified="2018-06-20" version="1">MPTGDNSGKEEVPADLRDVEREKDKDRPSKSKGPAKTKDLSHVPCKFFKVGSCTAGSSCPFSHTILEPGQQKEVCTWFVKGNCKFGHKCALAHILPGQSMSMDRKNKKAAQAAATAANSNAASPREGHRGGRSQRNATQGLQGGGSNSRNTLLSGSTAPTRSLSSSRPLPLKTTLSPSTPAPPVQDTEFVSYGLPDESNKLPSAPAQGKPASSSSSDVLPASLASSPRADETTANQLEDENGHLSINDSFSIRRNGQHDLADALDFGPVGSPTRTTQHSVRIARVNGFSPGTSPQTAGLSTSPFSAPGTQSVFMVQEHGGGDTKSRSGLSASLGALMSWGTDPRPSTVRKPSVAVYDEVVVEDGELEEFIPSSLTDLLTPEERSRRFSRTTSGRPILTSGVDEDSSGQSVAGDGHHHRYSRSVPAPSLLQDLRSIWTDGGRVAVGSPDAGNIGITGGGLGNGTPSSFQSNSGFGGRSEDMLAPSNASAAFLPGLHHYINAKSNLTAGMSSLYAHTGAMGASQQVGGGYGGLNGMALSPPRLNSFAGNSAFESVPTNPPHSQTHRHTSSARPIASDGTDVYPADPDERRNAFSPSMRALQAHAPGQSLPQGLAAGYSRIHALPPPPTIPSPSTSGAFSPGRPSGFSPVAKGMMHGQNGSLDWHNSSPTSGGIPDQLGHGPQDLATTPPSNASLGGLENMFSRLSYSAAASRSNAPAPPGIVARNASGRSWHNGQGPLSPLSGPVLTGDDDDLFSMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEL0</accession>
    <name>A0A2R6NEL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEL0"/>
    <dbReference type="STRING" id="98765.A0A2R6NEL0"/>
    <dbReference type="OrthoDB" id="3268553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="222"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="499" mass="54946" checksum="2D94D6A984A29FE2" modified="2018-06-20" version="1">MQAFQEALAHKNALREKRSQQVAAFQVSDENFGLPSSQAPPSSQIRMLRAAQQAQVLEEDQWEMQQDPNADSPVDDINEDEDLESIDNITMTGAEWAALSPRNPNLVRRFSHLKTTTPTPVAASIPDAPCRPLVRRLNKKASTVTPTSSQESVLTASATPTPVTNKPTNGMLAPNIASAGTKRSAEDLSETEDDSARPTSAKKARPKVSDVADTLRRAVLQAAIVKYRCGISTLAAFPDNPTHADDMAASSWFTACKDSHFLRTSDPLPITEDDVKVIKSRAPQIRGEVKIAARGSVKTGYGFFTHDGKDETIKKNRELHALLVTDGAFTWTNPHNVGARGTAYRHPVILDVIIKSWFSNRKDEGITEDSYFNAPGIPLVTIALVLAAIQNSLDEWREGVFKSMDFTDKDYAKKYREHLKTLRGWEKLCKERGSKSVEMLQMDLLKAARYVSILCKTISQLNRSYSASAGLSDEDNLLSDTIPSLTDLIASEEFSDSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NET4</accession>
    <name>A0A2R6NET4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001321">
        <property type="protein sequence ID" value="PSR70789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NET4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="18103" checksum="3C3377292B070DE7" modified="2018-06-20" version="1">MRIPAFLAFLKSTSSVGQNIQTLILREGQRKDPYVNSPVLASLFPHLPCLHSLCLIDIAFRGAETPLPQLEPCHRIRSLSFRFKASESYTVQHVLDILGLFSHLDELRLSSDDPEGDKIIRVLDISKINICLQGSCQVASCRRTGERLHGHVGHTYPATICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEZ6</accession>
    <name>A0A2R6NEZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001302">
        <property type="protein sequence ID" value="PSR70926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEZ6"/>
    <dbReference type="OrthoDB" id="3244156at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="416" mass="46263" checksum="9F9B055FD0274402" modified="2018-06-20" version="1">MTETLEVPFGSKTTQRPLSRRLSGRRQSHASYRSWISTLATPHLGSGGMSSPPPIPVTFEVHSPASTTRTVKLSQAPERKQPGIPEATESTESKEIPALQLLISTDTGGDIKEFDGQMMSPVEEGSEHPTTPTVALRGRARSLVDGLVSGIRSIPRAVTHSQLHDRVSLGRESSRVSHYTRRTASESEEYAYKFPNQPLPYGVPILLAPPFPQGRLGPPMTMSGPPTSKISDMDSRNGHRGFLGELNSLPWISSRVAVDYFPGVSRSTSVPSKSLSSWYTMTAPSSPSPILRPEHVLPDPWFAPTRLDPAWEVPEEEERAAEGDDGMTMEQKLEKTRDELQEKDRELDGLRQIVEHQKKHIGALEAELTELRKAEEVDLHRRKSSMRQSLRARDSIRASMRRTSMRVSRPSSSFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF24</accession>
    <name>A0A2R6NF24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001298">
        <property type="protein sequence ID" value="PSR70987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF24"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="16433" checksum="BD20E6A5E281F990" modified="2018-06-20" version="1">MDTSGQIRLLECERIWKKSAEYYREGRARAIRKREEEARGRRRAEIEARGREHEASEREKEKDLIRHGRTLRATCTSRAVLSYRAKPASNLRVQMSTSQSPPKDRDDGAAFEYHRRTEGRVCCQEIRADVIAAVAKSVEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFK1</accession>
    <name>A0A2R6NFK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v13010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFK1"/>
    <dbReference type="STRING" id="98765.A0A2R6NFK1"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR71164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="10473" checksum="AE1896D49893EF56" modified="2018-06-20" version="1">MASKGWFNLESAAGAIPETQFFEGDSAFKFLGLTKTQRLYGFGGCLAIGFVLSLLGSILLFVGQLGSFAILYAMGTVISLVGTGFLIGFGRQIKTVIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG57</accession>
    <name>A0A2R6NG57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Moybdenum cofactor oxidoreductase dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001286">
        <property type="protein sequence ID" value="PSR71365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG57"/>
    <dbReference type="STRING" id="98765.A0A2R6NG57"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="5">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="14125" checksum="CB2FD8E61D9BAFB7" modified="2018-06-20" version="1">MADAESWWSKVPPVQSMPLNSVGAIAKLTKSGLHVKGYAVGGQSGQVSKVEVSIDEGRTWQPTTIIYQDGPWSWTLWEACIRLAIRPDQLHGKVYSRAIDVSGKVQLQDTDWNLRGVCYSAFGEERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH42</accession>
    <name>A0A2R6NH42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001249">
        <property type="protein sequence ID" value="PSR71694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH42"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="283" mass="31187" checksum="D3BBC3CF216B129F" modified="2018-06-20" version="1">MASARFLATLHAVRKAISPEQDFFVQFKENIIYHAPTGKFGVVCLSSNIDEVFNKLKDAFGTGSTPNGSSLLILAEVLSDSLTRFISDTFSTDCDLISPPLLLALVEGLLLQSGLIRLMAGLTAVLVLFTNPLDSEDYITEPKEYALAATRLCESNLKQEHLKAENRHMFVVMANMAFLPNRLVLPEDESSKMERLCDLLQSMTTVFQTALDRGWTNCGTHMDLPWVDALVKGIKESSQQPSPLVSLIPSVLLDNIGGKGIQQGLISGKHVQMQYNELLKICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHL8</accession>
    <name>A0A2R6NHL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001282">
        <property type="protein sequence ID" value="PSR71482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHL8"/>
    <dbReference type="STRING" id="98765.A0A2R6NHL8"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051435">
        <property type="entry name" value="RING_finger_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22791:SF6">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="226" mass="26299" checksum="3DC252357FC80661" modified="2018-06-20" version="1">MIVLHPNSVCDVCLEVYGDSNAPHAITCGHTFCLRCLKSLTKQWCPLCRTSFSVEDVRKLHIDRCNTDLRARTPPLSDDYDDDDDGTCPVRTLRGRITRIVLDGAKASEVRDFIDEVRGWLSTQPAVEHADLRAAYLLLFKYTDLQYKVKEEKAVIAELQQHCEDLKEKIHAERELADVKYQELSQKRMDEMETAMAVERNLRERFDRMDKDWRDKQIPTKVRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHV1</accession>
    <name>A0A2R6NHV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHV1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHV1"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="515" mass="57787" checksum="2E2CC07D2CA8C618" modified="2018-06-20" version="1">MAFVDLRVELPAFSYSFHVHVHRSWSVRDIKEEIMRCCPGEPRVDGQRIIWRGRFLRDEEKVQDVWKSRDDARIVHLSVHPSAWTTSPPIAPEARPAVVVSQSQQPILRRSQPAPQSAGSSLIYIVQKHNNAIHVLTHGHVPSSSSEPADPSQHRSFAVGVLQSCGWLWPAILDEEYPPASGPEEGLRYERIIVENQPYLNLTTPNTSPSPIQQHALKVLSHTFPLLSIVVPDPSMFQTLPHNIPYPLTPTANLNQHLQQLGLPALRLAPHQNPNQNPNDPNNPMVAEIRAIPLRALLMPLIMLSFRTFILMYFFSPSKRPLFGLILSAWILYETWGALRAVLGNDRPVVPPGGGQARVGDGAPGLNNQRGQPGQPQVAIPAEAGSNQTATRGNTDVVLRRLANMNLRREDAMLERDVPAPEPSLFHKANAFVALMLTTLHPAVWDRRRTALRRREGRLRTEANMRETPSTEEGNSEDAARTEARAQVVARHERRPTWVKHYVNRVQTTDWADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHV3</accession>
    <name>A0A2R6NHV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001271">
        <property type="protein sequence ID" value="PSR71562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHV3"/>
    <dbReference type="STRING" id="98765.A0A2R6NHV3"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="306" mass="34256" checksum="A8BBE10205B7F9B0" modified="2018-06-20" version="1">MDAESDEDDSGMDLDMAVDMEGSSDEGSEDEEPAKFIPMPASGGAQELRDKLHARMASLRRGGPRWYADANGEEEAGSRDELLEERRRQRAQMREKRRKETREKIRREEEARGKKGKEKERAQGPTTKQQLLVPDQSSGSGSKPAPGFANVAFAVPGSSKKAGTALKTSSNPTQALAQLAARKEKVALLPEEKRKEIEEREKWEKAEARMEGTKVHDDESRLKKAVKRIEKTKLKSKKAWDERKEQLSTSMVAKQKKRTDNITARNERRNDKRKGVKPKAKDKGRPGFEGKSFGKGKGKGKPSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI43</accession>
    <name>A0A2R6NI43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI43"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1066" mass="121993" checksum="BEAAF7509C04C559" modified="2018-06-20" version="1" fragment="single">LTTASFGILVKQWLREYIAIDYTSPRARLRARQFRYPGLAKWKVFEIAALLPLLLQLSLGLFFVGLCMFTWSIHPSIGKTSTTIIAGWGFLLVTVTIAPVLSPRCPYKTTLLKVPLKSLRRLLRRSYLFRTLYWKLRNTTTKEESPIDPTTAAEEQLALQKEKERLLLLEEDEAVTNEKSDSEMLVAVDTILLDDDLLRTTMYDSLRQMQPDPADVVKFVLQVIDNRLQRKIYPPSLEDLRQLTKTAWNAVVDIIADTLIRNFDLGTSTTSVPKWMEDALIILLSLSDFALTKSGNQALSKWMSVEVRKHASRVIASHVSDDHWFAYPLRRLCTLYTISPSIDLRESILYIVRDRLAGGDPDMRFSDMILTRPEVPTDIIHTVLPLLLDKVKEVSTPASPGWTATTNHTWETIMSIPMPLGVKKSFSELLELVVRGRYLFSAIKCIASLNGDHAIEPAAVKNFVQAYTDIAFEGRYEILHRQVAMLMAYVDGVYKDAESWEPISPVRLCRLYLQTLDAAQKTSTSESDVELRSNWQELWNIMASAIRYLKLTEHYDVPEHRQLAEECLTWLQDLDDGTPPTRHGDDAFGHREEDPSKVDYRDWLRGFKVEESMFPDDLVRALSSFVPHDVALMFNRVKRIYDPEVRMQAFASGMQGPSQSDNDAQVSESGGQATTYSNHSVALEVIPRWKILIEMRSTPSDIIRFVRETIATCLPGDTLFSSPSSIFNLRHITRRSWEDIIDIIADTVINDFDLDLELSSWMEDALVILLSFSDFSLTRLGSRALSLWMSPEARMHASRMIASHTPDYKSFTHVLHRLRTVFASCPTGNAVLCVQDIVRSRIANNDSSIELWDIMRTQRALPEDAIHVALLILSDILTTRLSKDWQSLWAADEQAALQRRTILQNQRDALEEYINGVFDNPGFYPMSPVRLCRLYLRILNAAQTNDALDVKLRADWQAIWNGTAKAISHLRSKEYDVEEHRMLAEEALVWLDELDDGRPLKLDAIGNEVDMEPKMDYAEWLKDFKFWESMFPDELFDALSTFVLDGTAMKFKRVRRSRELSTSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIV6</accession>
    <name>A0A2R6NIV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIV6"/>
    <dbReference type="STRING" id="98765.A0A2R6NIV6"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="171"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="33095" checksum="D1DDFAF3E78B8FE8" modified="2018-06-20" version="1">MVVTTRSKGKERALPEDEVPHKIAEVSSANSSSSDSDSDSQSDTSEESDSEEEITQEFLDSLLEKARQNAASSSREKVVAGLLAGEEEMIRLGEDDLEEQPLPPLDPGTLPTPYIELGETRGTLPSKVRDLDVERAEQDSTSALPKAPAPPPSAAQLGKPLTKKQQKALQHKTAGASWFDLPAPAESDLPKLYREVEALRLRNQLDPKRFYRKDEGEGKGIKGLPKYFAIGTIIPDSTPFGTASSDNLSRSQRKRTLVDELVDDAEAKGYAKKKFKELQTVREARGRGTLARKQASRKPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ79</accession>
    <name>A0A2R6NJ79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NJ79"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1405" mass="155788" checksum="B7342F8F43436B5E" modified="2018-06-20" version="1">MNVSDLLSESPSLRRQPNREQQGQPQPQERSRERQAPPQSQQQHQQSLAQQQHGPQHPPPQQHQQQQGSYHTHGSSRHNTRPPSPHGYSHEYGHGQPHRLPPPSAIIGIPDAYDLKHRRPEHESLPHPHELGMRGHHGPSSPRGPPGPPQSQQYITDHRPARLQASASNHPHPHHHAAAHGHSNAPSPMYLPPPASRSALTTQPRHVAGSPTAPMPPPPGHGSIPLYPTPVGPGMGPPHDPRGPPNYNEPSVMYSGHPHAPPGASVMGALPPHSQPRHHRHPSSGGGGYNSQNGSPAMGSLQRPGHFEEREFGGHSHSTGGNGPVGRQGPQIPQHSQSSGAIGSGMTSSALAHSPGGPPGGSMNTVRSGQPMMPSSSAGGMHRDSIQVELRERERRNAERRDRDLQRDRERGHREHEREEERMRERERPREHDMSGLVIIPEGERENGGREWVRKMQVEKSREDVWPRFAPPSSREDQRERDPREYSRDRERRYREEELRSRDTREPVRDVERVEQHGRQLPIGGRTGPLTRELREKDIGRERDGDRDGRRDRNREPRKVSREEHGWLPEPRANEVWLREQQERERDRELRERMQRDWDRDPQRGEMEAMRPSGQQPQTPHHHHHLHHHHNHSAPSSVAASSSQGYPLTSKPLKTHRPPEPMDMALGPHSMVPPGGMPPPSYGPVMSERIPGSHKMQPKMSNGLGPSQAIQNQLPPQRNMSLHPHAHAIGNSPSGYPPRRTPPLPFANLMTQNASSFMQPHSPRPPIGPTLPPLNLGIFVFPHTPFPFLDFPSPPPDVGQGSNVPPVTEKDVREIRATIFLPSGFIPTQKPKRPRLWGGAPIPSFSPLFASPQLVNHLQSGMSYGFRRPHPLEIHGTRRVYTDDSDLFLCALHAGWVTWSKLRHAKDNGKDLRVEVRLTREARYVGGFGAAHKGDSDDERSAGEDDDGRTLLSFGWGNSHDGSGIEILRAEFVKKDATHSSGLRNRNQRLSEYAQRRSELNCGPLTSSPSPRKRRRYSSPVRITEQDSVITLEARRLDEKLCAERTLVFGNRPGWFSTGFMYDPDTVKSILFDESDHSRPRKRQRLLAEDTAHTDADDPSHTGEADSASILIETLAESFLISRQTTPTMTDDEKENAATSSSLLYTIALVARSEFAQSAQKTPKKLQSIAVPPEAFAGQRDTEPAVPTSAFPSTEQSEGTSNNAVKLTTIEEPAAVTDEPKSTLIGTKDEVKAPVTNGDTAKVDTAEGKTKSAGLTSGSRATTPNAEAAATGAPLINGNNAAIVPKPSDVGAETQDPLIGQAVLSPLGKTPVESTETPMDIEKEKNEDVVKPVSKLLPPEDPNSNQEEQVPDVQILQRNLGEDDLIFDTDGISILGNEVENGMRRGWKIKARSWRWAEPLLKETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJD7</accession>
    <name>A0A2R6NJD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001161">
        <property type="protein sequence ID" value="PSR72505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJD7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="5614" checksum="266CE23CBB17C804" modified="2018-06-20" version="1">MESNFGGGDKVGGVGNVGLAAIVSGEDTGRSVGMLEVEDLGLVLKVPEKRSAGQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJP2</accession>
    <name>A0A2R6NJP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">chitin deacetylase</fullName>
            <ecNumber evidence="14">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v11682</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="14"/>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJP2"/>
    <dbReference type="STRING" id="98765.A0A2R6NJP2"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="16">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR72468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="268" mass="28952" checksum="FCA128C50D4F9C22" modified="2018-06-20" version="1">MVVCRTLLNFLDEKELKATFFVVGSRVIERPQVLVEEYMQGHEISVHTWSHHALTSLTNEQIVAELGWTREAIKTVLGVTPTTMRPPFGDIDDRVRAISLAMGLTPIIWTSTPSGIKFDTNDWRVAGGQFTGPESFQSFEEILGNATTLNNGFIVLEHDLFEITVDMAIGYTLNAAMTHEPPFTLEPIGVCNKIPTTDMYQETTTNKTYLAARQKALSNVNSTTSTGSSSGSGSGSGGVNKSGAMQSFAMVSLPVLSAVAAAGFALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJR6</accession>
    <name>A0A2R6NJR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJR6"/>
    <dbReference type="STRING" id="98765.A0A2R6NJR6"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22597" checksum="9A8641ECCEEDABFF" modified="2018-06-20" version="1">MQPLREEIDAVIKEDGWTKAAMGKMRKLDSFMRESQRVNGINGVSVMRKALKDLHFSDGTRIPAGTVLVTAANATHLDEENFHNPDIFDPFRFSDMRDEDGESTKHQFVSTSVDYVAFGHGKHAWLVDSSFPSPFLALIFMFNLSPGRFFAANELKAMMAHVIATYDVKFSNEGVRPANKWIATTIAPDPTATVLFRKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKC2</accession>
    <name>A0A2R6NKC2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001135">
        <property type="protein sequence ID" value="PSR72776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKC2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="353" mass="39434" checksum="6E24BF51CD6C59CF" modified="2018-06-20" version="1">MQIGPIAVRRRRGVLLREAKIDILCQARDLLDKELDALEVQPVEEDTIESPSVADSQEIDEDVKQEDIGWDVGFISQHEYRSEGTTSSEIDNVGPSPETGPDEDIDSGCDTDEDGGNSSTNGNTRTVPSVPCDTISYQPTVSDASSTTYSTQSGAINPLRLWTTTSLAQTPPSKSSIRASPCIRDFRKQQVLPAEPAGERKNSRIYKCLIKGCPWTFKHSGSRCGHMDTHFKDYMCYACTEPSCMEGFKRFNALNTHIAAKHPHAEPLVRAQYQPRISAWMTMEGIKYLDKPDKNDPLYPKLHTMFARAGLVRAYSENHEEEATPDAEWLDTELEDDMGPESEDEDDVVQRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKK1</accession>
    <name>A0A2R6NKK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001137">
        <property type="protein sequence ID" value="PSR72758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKK1"/>
    <dbReference type="STRING" id="98765.A0A2R6NKK1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328">
        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="27963" checksum="5CA1A19BBB67C780" modified="2018-06-20" version="1">MAQPYLHPLQVNPRTGEPFLRLPTPLDNFIITPPRSNDAPALKEILNDPRVYKTLESPPFPYLLTHAESYLDMITKECDAALEEAKKAYKEGASEPLGHVENCPVRYIREVKEDGSEVLVGDIALHRCQYPDVKDQSEREELVRTNMRYAVGDPEIAWCFSDLVAGPYHGRGIMSGALKAIMDQWLIPRMGARFIRAEAFIGNVGSVRVFEKNGFVMEKTVQYEMVTNCGVTRLGLHVLCWRSEQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKT3</accession>
    <name>A0A2R6NKT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001132">
        <property type="protein sequence ID" value="PSR72848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKT3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015347503" evidence="1">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="133" mass="14917" checksum="4D5C88AF675D669F" modified="2018-06-20" version="1">MAALNPILVSRFLLNLQQVEGGEINNTNTSSMATFRDLWLFVTMSRLGDLGGDLDHGPEPEEVEILMEEFDVRDVSEEASRDEEAARVVDIRLEIVPQALPVEENPFEEFVVGSSRDIQEVPRFGHGMTQEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKX5</accession>
    <name>A0A2R6NKX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001148">
        <property type="protein sequence ID" value="PSR72642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKX5"/>
    <dbReference type="STRING" id="98765.A0A2R6NKX5"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21362" checksum="B5FDBFAA9576B20D" modified="2018-06-20" version="1">MGVVSAAAIEKGGQVTGVLPYAMVAAGGEKEQTDGEIQAKIAAGILFDGENRENVVVNSMHERKLEMAKRSCGFICLPGGYGTLEELLEVTTWSQIGIHHKPVIAMNVLSYYNPLRELIRNGVKEGFIASRNERLIIFVDGPEDLAEHENFDWGKAALGVLEQWREEGARSDDLLYDWTQRKGENASNGEELGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL87</accession>
    <name>A0A2R6NL87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001136">
        <property type="protein sequence ID" value="PSR72762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL87"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="6094" checksum="2CAB579B6037F2D9" modified="2018-06-20" version="1">MGNTSVSDVQFFNSSGLNESEHLLVMTDEEESMEQHHSCYPEIISVHLWQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLD8</accession>
    <name>A0A2R6NLD8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLD8"/>
    <dbReference type="STRING" id="98765.A0A2R6NLD8"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="46932" checksum="74572ED259F0ADB2" modified="2018-06-20" version="1">MSESNGNAGSSNPTPSKAIASLAKKQGDVTRMGAQKLKFVPTLPARRKKEKKHLQQPPHPRSEDVGVGEEMEGDEGEGEEAKVKMTASGPFAMGPALAGTSARRTAPRSNFTPVIPQGPGASSRLGAGLTQTTAPSLGVKRELNDLGVSGQGKGKKLDEDEGEVYSDPDEGVEIVDMENVRTMDWMAPESLRKDKESRKKKVKKEEKINVDPKGKGVDMSGTTSGTTSAEPEELGNVNLANALHLSDSEDEEELEDIIDDFALAMDMGVDEDVRQERLYFFQFPSPLPTFYSSSPRPEAEHEINATEPEASGTSKVKFAEDTKPAAPGAPQVQQEESAADAKVDGVIGQLEVYKSGAVKMRLGNGIVMDVTAATQPSFLQHAVYIDSENKRLCVLGEVNRRFVVSPDIETLLASMEAADHPAPPELEIDGLISMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLQ0</accession>
    <name>A0A2R6NLQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001100">
        <property type="protein sequence ID" value="PSR73178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLQ0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="106" mass="11841" checksum="295C204B42D9D22B" modified="2018-06-20" version="1">MGIRTTTSAKTRLKRRNFTTEANDSSKISHITFRDLSAAPFFAKDPSKFAGPRFIPEHRLYGTILAQHVSGLPEQPTSSELNIKTNEPFNALIFGEEVRQFTLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLQ2</accession>
    <name>A0A2R6NLQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001084">
        <property type="protein sequence ID" value="PSR73330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NLQ2"/>
    <dbReference type="OrthoDB" id="2536866at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="300" mass="33413" checksum="D2231186D2C8CB29" modified="2018-06-20" version="1">MIILDEKMPPPPPYAPATSLTTPPPFPPPFPYNSRAPPRLDTLPPHLLLRVVYATFNQASSIERQRKTLYWLTVGLRLVNRALYIACMHVLRSTYLPAYSGFIRPPYTTDPFPLNSPTFTPDQMVSPVQSLQRETRVLDLFVALKVREDVWMDESELHLERDESFRDLFDLMQPRSRMEDLVRAYGVREGVIALANMASSSTNGIVSGNANVVSKVPAGSSSNDGRTSSRSKAMSKAPALVPFGALSVSFSSRRVGLVLTTKERKRTIVETERAKDERLEIAAKKLVKELKGWVAARGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMR5</accession>
    <name>A0A2R6NMR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMR5"/>
    <dbReference type="STRING" id="98765.A0A2R6NMR5"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="201" mass="22449" checksum="E3BDCFA41A703F3B" modified="2018-06-20" version="1">MSSITFPNGASHGLSASNSSTADVDYFETGFEASPASSFQMNPLSSHPPRTPRTSVASRSHEYGGDIYTPQEEHIEQGTEPLSDDEDDKDREAAKDGIRREEIWHEMLKTSYGRDKTFKTIQYSMRLYLLFHATITGSSLFVNSKRPLWDRELIRRLESGVAGLSLTRYVTSTPRKAGCVAPLQPPHVEMHSPPPNPTDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN76</accession>
    <name>A0A2R6NN76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001071">
        <property type="protein sequence ID" value="PSR73512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN76"/>
    <dbReference type="STRING" id="98765.A0A2R6NN76"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="866"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1158" mass="129450" checksum="E6EB7A22F4AFBE87" modified="2018-06-20" version="1" fragment="single">TVKKSPEDAAQRVLLQVDLDFLPDRDLSQRTEVDRAAPFDEEVGEAWKNPLQLSGHNGESIPTHGLRWRNFVQQLRALAWDDQPETELKLEWRKGLTSGRGTRHGTFPVILSSACLLDILPFCVEANLETLGHQAVDITVHAPAEYSQLDLTDLCGQLGVELCAQSDAGSVPVDLNYAIFFHWVAVNLSDGDRESRILALNDFTVSFQRRFQVSHEKLDLSEGLYLVLRALSLCDREHKLHIKLVDNLATWICRGIEQFGITDQLEQAIQWCRDNVLTHPPEHAGLLNLIGSIFTTRFNTLGERRDLEAVISLLRKAVENAEGETRIDAMCNLALHLRFRFSLFRVTEDLDEALQLCRQGLSMISEDSADVPRFLRCLSLISRDMDHLDEAIDTLREAEKLCVTGTQLHVEILQELSRYLVHRWQRLGLKTDVDEADRVHRKALELLPPGQEQDRAFLLLDAAKILSNRSEGTSRIDEVISLQQEALALLHENMFRHLGHAALAESLLLRFSARQDPKDAAEALKNITEAIKVTDTGNGLMHRAHHLAIIAEIYIEPNTPYHDFTTAYRYLQACLDDTHCDAQARLTFMSHALRRLAKSFGTAANPYTGFFNPELVDLHVKAVRLLPEIAYLGLDIKSRLQALRVFDGIVNDASVMCGSVNRNVEALEIIEEGRGIFWTQSLRLRTALYDLPESLSERLRNASRQLEAGSYGTEGVSATGDSRRIAELDVVHRRRIGEDFSALIEEVRAIPQYENFLKPAPLDLLAFAAEKGPVIVLVSHGFKCFAHCLFKLDGDGVDSNFKLLQVPLDQIKKESLERMSFMLTSANEQSRKARRSQEGESEMRDAGERGDRAGRISSASSQTPEKVLKTLWERVVKPIFDAMHLKPASGRDRPRLWWCPTGEFAFLPIHAAGDYTKTGQSCSDYVVSSYTPSLTVLINARRTFEPLVRNKVKALLAAVPRPFKGDSLQGVVSELQQIVDVVPSYCQLPLPTADDALHGPQAGATVKTILEKLPETSILHLASHGIQDDSSPLESGFIMRDGMLTISKLMPLPLPGAFLAFLSACETAKGDDEGSDQTIHLAATMLFAGFKSVVGTMWLMNDEDGPRVAKTVYEQLFAGEDELLDPDAVPYALDDATRKLREQGLSPSRWAQYIHLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNI1</accession>
    <name>A0A2R6NNI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001037">
        <property type="protein sequence ID" value="PSR73979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNI1"/>
    <dbReference type="STRING" id="98765.A0A2R6NNI1"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF15">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="473"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="631" mass="68244" checksum="15EEE355CF0B4E02" modified="2018-06-20" version="1">MNGDASAHNHKDFLDAFFQQEQPPSHNQSSIDSSDIFQTASASSSGHHSSLGNMQQQSMSNNGLGMDVLEGLMGMQERGGQSGMSSGAQPTPQMLVEQQMRLNQLQQLYQLQTQIFQQQIELLSGQASFSSLSGTPREQQPYLPTPAQSTELPPQPSPDFVPPMLLQSTEHDVGNMGHHTQHHFIPHQIIPTAPHSAPANIVFQNIQSPYPLPSPAELDFDEMSPLTSPWLGAYNTNQPTTNTNTRSMPSSSAGTKRRTASPSSDELPSTTGRPSRKRQAAHNRIPQNVPSLQGKKPNLRGTKSANSTPLFPATSNQGGSSGRRGGPSPLDIPGDTPSPVDLSMPPPATPQPLAPMDFLHEGLSSENASAPTPMPQEHITPVTPASIMNIGRSSHNISTPSTQFSQSQRRSQDRLPKPPRRPRSATVTSVPPPAGIKTAVSLVSPGLKPILPAGNISGSMSPTGPLPQPTLQVRKTSHKAAEQKRRDSLKTSFDDLRLLLPPIPLPSEEGYPDEPILPGAMPPRGPPKGNADGPNRGVSKLQLLRCGNDYLRRLKGRVERRDDEIDKLRKEIRRLRIVVGSEYMQTEEEGDGQEPIDLEKDLDAEESSLGPLGRYPGTLYEGDEGDDDGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNY0</accession>
    <name>A0A2R6NNY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNY0"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="15415" checksum="02111AFBCAA4328B" modified="2018-06-20" version="1">MAVLGTFRLLSSPFRSKGKYGTVDEQFSGFVLVGIPIYYMTQRSGSTDTPLIVGEYRRNQQICRNIAQFIFSASFRSHPQRYLRTASPDYVADQRLGQAGKLWLPTETNKWRWPSNTPDEIRYPIPGTRAHYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP65</accession>
    <name>A0A2R6NP65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v10002</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP65"/>
    <dbReference type="STRING" id="98765.A0A2R6NP65"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01801">
        <property type="entry name" value="Ubl_TECR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049127">
        <property type="entry name" value="TECR-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21696">
        <property type="entry name" value="TECR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TECR-like N-terminal" evidence="13">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="162"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR74258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="318" mass="36130" checksum="EC65CF7046A6BA39" modified="2018-06-20" version="1">MVQVTISASGRKISLATDLPVVLDIPAGLDSATVGDVKAAFAAKYPKASAHSRFYVSRQKLTLKDEKKALADDTTLQNAGLVDGGVLQIKDLGPQISWRTVFIVEYVGPLIIHPLMYHFPKVFYGGSVQHSLLQHYVYAMVMLHFLKREFETVFVHRFSHGTMPFAYIFRNSAHYHLLGGLGLAYAVYSPTYSSSSPYIRGTIRDDPKFLWACTAIWLFCELSNLKTHVILRNLRPVGTKKRAIPYGYGFNLVSTPNYFFEIMGWIVVCLMTGSYASWVFTATGIYFMGTWAMKKHRNYKKEFGKEYPRRKIMIPFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPA5</accession>
    <name>A0A2R6NPA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000996">
        <property type="protein sequence ID" value="PSR74319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPA5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="169" mass="18660" checksum="38E78D97366C15AD" modified="2018-06-20" version="1">MFAYVSMNSECVNTPDLRSPTGKPLAEAIPSTGDRLFAGRYDEKKPAPADKGDILVESGEILESGKLKREAGSSRIYSYISLSLLKSVGKNISKYPCFTRSVSQATDVPFMRVWTTGAHTPGIASGKEEKSDSSNRWRGKYSRRVRRRDKRRVGINSGAERLGARGRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPG0</accession>
    <name>A0A2R6NPG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPG0"/>
    <dbReference type="STRING" id="98765.A0A2R6NPG0"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF277">
        <property type="entry name" value="GLYOXYLATE REDUCTASE_HYDROXYPYRUVATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="276" mass="30182" checksum="72D5621A3B088427" modified="2018-06-20" version="1">MSVGYEHVDLDAIAQRGIKLGYTPDVLTEAVADISVMLALMAGRNVKETMQVVNNGEWPKCTWAPFSFCGPQLSTNWMTTSRTVGFLGFGRISQATLARLVSFGFTDCVYTSNPSSQADPEADARTAEKYNLRSVRRVSLDELAEKSDVFFVLAPGGTKTHHIVNEDFLKKMKKTSVLVNTARGTLVDSDALAKALREQWIWGAGLDVVEGEPNVGLDHPLMKEPRYDLPAFHSVRLAVKLILLQMCDPTPHRKCYDGDAARYGDVGSQKPSGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ26</accession>
    <name>A0A2R6NQ26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ26"/>
    <dbReference type="OrthoDB" id="3228793at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23422">
        <property type="entry name" value="beta-trefoil_Ricin_MPL_CNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="88"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="280" mass="30438" checksum="FCEA6EAF1067B280" modified="2018-06-20" version="1">MGNAPSSQSQSSRSIRSRISGKERDLRDGPSIGRLSHVVSFYETPPGSLKAGRHTPGPETPAADVTEAKPEPAAIQDPDWDRLAKQLKWKPGVYTIVNAQSGTVVDLSGADNKSVIGFPQHNGKNQQWRFAPSGGGYTIQSVSSGEYLTLDSISDGGALRMSPFPVAWRVDSGNEENELLVRILWPNEKYALELADFGNPAPGTKVQLVSYKPEQACQLWRMIEQQVDSTSEDMRYEATSTTAPSEALVISEDKDAVTTTRTTTTVTTVTTVTKTPRPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQC5</accession>
    <name>A0A2R6NQC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQC5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="258" mass="26448" checksum="AACD241754567605" modified="2018-06-20" version="1">MSLYAVDSTSNGTLLDTFIGLPSSPLQWFVDFVTPSNSAMFFRVQDSTGATAASPPFSVTVSFNNSSGICPFTTDIHPSATNSAASSSTATLSSGVSPTGAQTSADPFISKKASNPDDCEQIKQSIDEGGSSARRPDLLGDNPSLLRVNNIEGRGEFNDDAPSTIVTSSVAVITSAYNGTRSAASESSTSKLPPQPLPPVAATLPVETSGPAISSIGDGNSVIAIGTQFPESPDDDGLRSQSGYATSFSSQPPAYFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRQ6</accession>
    <name>A0A2R6NRQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000892">
        <property type="protein sequence ID" value="PSR75476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRQ6"/>
    <dbReference type="OrthoDB" id="10602212at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="21561" checksum="1D97AEF08EAB3BEB" modified="2018-06-20" version="1" fragment="single">CPRAFVAFRFFLVIGIKRRLVIESSGEALAPLPLVRSSRLELEGAPHRRKRTRVGEPVQQTGLSPAVTAPDVVVTSGVCSTTATTSMSLHAVPQIDSMASIQSACDTLGLDINELHEDAVSPLATENVPTDIEIVTEQDAYWYALDKVGAIFRLDRFVYVFQGWDKKNNMLEFLILQQHAAVAEQAPKLSNPLEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS60</accession>
    <name>A0A2R6NS60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Caffeoyl-CoA O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS60"/>
    <dbReference type="STRING" id="98765.A0A2R6NS60"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30692" checksum="07BA506C491DFF73" modified="2018-06-20" version="1">MSAVSDHQHPGDTPHDRLALLIDQLCLEIDSQPASTTDRVRTLATQAKELIDGYDSYMSGMSSPHPPVLDTMLEEGNKRDWKRIHKEGKTQFCLVPAMCAGTYEAVVLQHLAKLSKARTILEIGMFIGTTTVSLAMLPGVEQVVSLELEGYLEEINRPYFKLAGVSDKIDVRIGDAIASLDKLIEEGASFDMVFIDADKPNYINYFKKVVESKLLAKGGFIAADNVAYKGSPWAPDQSYRMGPHIDDFNRAVREYPGVEVVMLSIEDGISLIRRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS81</accession>
    <name>A0A2R6NS81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS81"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="184" mass="18995" checksum="8754AF3576B6B81C" modified="2018-06-20" version="1">MQRGSNHMNFAKLSKRSLMTGLLANRQRATDLQKIPQHNSPLKPLSTLRYSTMFSKLAAFIALASPLLAVATPAAVARNTAPANPTTACCSSTVSVSTIYPSDFDDALNYLVKSDSAQGIAALSSIAVVLSGLAVPIGLDCSPISVVGVGSGSACDSDPVSCSNGVIIATYAEYALKLPPNPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSR4</accession>
    <name>A0A2R6NSR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSR4"/>
    <dbReference type="STRING" id="98765.A0A2R6NSR4"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6253" checksum="03EB37287FF41C0F" modified="2018-06-20" version="1">MSSNVDDPQWHTITVRVPFTSAKHASIAKQAIEVDKELQPLVVKRVLEVENDVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSV1</accession>
    <name>A0A2R6NSV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000867">
        <property type="protein sequence ID" value="PSR76018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSV1"/>
    <dbReference type="STRING" id="98765.A0A2R6NSV1"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="72720" checksum="70FE1C94BF9F0BF4" modified="2018-06-20" version="1" fragment="single">MSQNPPRQHVVHGGIAAMLTGKDEPQELFCERKACAHNVDYNNPLPEGESLYWVENRASGDTQDGIESLSNADIQCLMWNVHIKSQALLPKMIHITIKNLFDKMLRGHSVEWEVTDNVPVHIGAAALKELAFNTVQELWAEHCGGGGFRLTKADVILRSSQDTKIEPPGPSTPDFDAIAQQFFKHKGPGGTGPLTFKTGKAVVRLQVKEPFYAEFMEWRDMRDEEEAKRDLELRRTSPSPPSTKLRVSPRPVSVASRSPSPELLASPSPVLVAKGPPQPRLRQKSSFDVDGFMELNAGQSHADNFNLNLSAEPLLTPPEPTPAVILPSSSLEPQPEASVKRCTPGFRFHPLPTAPRLGPPNSWSALNGLRVQAAHGIAPSAPQLHNPIERGVVRGREQTTPTRSRADVHVKRNLGFGAGDLALALAVPGGFTLLVNSKVVHVLVRGISEFRTLEEVIKAGNTSDLTVSAYLGEERASTITLRQDEYHRGHYKQAFFGVSSDLLFAGVATKKVCVKQVVYERNGYIVPFDGRKQARELMSDVQCLVWAGPLHNLAYDFIAAQISKLGHPDFTIPSMRFVKASLASEKVQRLPNVYLIEEMIEPATENGFRKYINNDSAVPLLLDDDSRSVVLRCEFLSFCQHVQYWKTNKTAFVTDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSW7</accession>
    <name>A0A2R6NSW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSW7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7517" checksum="F6C3F40F2FE6225D" modified="2018-06-20" version="1">MLPSFPHKDPSLNVPRAFVPSRIGRTKLFHASSSVPLFSDPRDMHPSPRPQVAATRWSQHAPIGRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUX3</accession>
    <name>A0A2R6NUX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000809">
        <property type="protein sequence ID" value="PSR77196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUX3"/>
    <dbReference type="STRING" id="98765.A0A2R6NUX3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR77196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="229" mass="26149" checksum="2A6EBFFDFDC53048" modified="2018-06-20" version="1">MFHQDAHDALEDWVNRFDLPEIHRAVLTHRGQDTTLKDTLASTTDINMLCHRGWTPLEWGIRTFVPGVVDILLECGADLRKGFPLHQAALRGNIDALKSLIRFGADVNLPDKNGRLPLHYAAYRGETNIVEELVRVGGDNLRLDAPDHRGRTVWDEYRQGRIWYTGLGYPPLDHDRVLRILSDLQASRFEADPRRLSPDRTLSEQGHRDESHKDEDDSDITMPGSFPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV38</accession>
    <name>A0A2R6NV38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000797">
        <property type="protein sequence ID" value="PSR77372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV38"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6796" checksum="9E271B575800E3A6" modified="2018-06-20" version="1">MNVTREVQTREDRARTQMLNLSDMKPMAELENMDAALTNVKARDDWELLKPREEAYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW89</accession>
    <name>A0A2R6NW89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW89"/>
    <dbReference type="STRING" id="98765.A0A2R6NW89"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF73">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015359152" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="60"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR78176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="528" mass="56035" checksum="290B12C940585F77" modified="2018-06-20" version="1">MKSHVLPLILSSLLALPADLAEAVRLGLQGKHIHPIRGGLNRRTSLTGTTSLNDTQDINYTTNITLGGNQFAVIIDTGSSDLYVTGTVPGSVDTGKTSGVQYAIGSVQGPVKTATLDFAGYTVENQAYLDVPESSSNTLGTGLIGLGPNYGSQVHQALGNSAGDAVLDRIFQQNTSTPNFITILLGRDDDPANSFPGDLTVGEILPGYEAITSQPHLEVSHVSIHDIGDQHWQTLLDADGVIGPDGKAIDISTVVATTSNKKQLTAVFDSGFSFPQVPSSVSEAIYGDVPGSELINDPDLGKIWTIPCDIEINISFNFGGKNFPVHPLDTSLDFNATDSNGDHVCYGAFQPISTATSPNFDMILGMAFLRNAYLSINFGDFVDGKTSQTADPYIQLLSTTNNTSEAQAEFVKVRGNAKSWNPDGSGALAWIKSHLPLVIGLAAGLGALVLAAIVFFCVRNRKIRRTPAGFMNMQSSYQPLNEPAPPSYDMQPVGGQGYAQAGYGQGGQGYIGQPPQHGNYNNPWDAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW96</accession>
    <name>A0A2R6NW96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP/ATP carrier receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v7722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000779">
        <property type="protein sequence ID" value="PSR77738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW96"/>
    <dbReference type="STRING" id="98765.A0A2R6NW96"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR77738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66445" checksum="52686EF041C217AA" modified="2018-06-20" version="1">MSSSAPATGVVERVQSFVSENKRAVLIGAAVAAAAIGGAAYYASTSRGDSDKGSRRKDKKKASKSSKKRRSVNDTDGPLLEEIKPKDVELVDDEVSLTSEAITSMSGEERSKVAASLKTKGNTAYSQRQFSKAALFYTKAIEITPKPEPIYYSNRAACYVNMQPPQHELVVEDCNAALNLDKRYVKALNRRAAALEALGRFEDSLSDFTASTILERFANGSTAAAVERVLKKLATKKAEEILKTRELRLPSHTFVSAYFGAFRPRPLPTLPENPSTGDKTLLLALEALGAQNYIHSVTLVNEAIEQGISWDAGKAEALNLRGTFKFLMSDVKGSKEDLLASVDLVPGLTQSWVKLASVHMEQGDPVKTFDCFEEAIKHNNKDPDIYYHRGQVLFIMNEFVRAADDYTKSTELDKDFVFSHIQLAVAQYKADNIANSMATFRRTLREFPKRSEPQNYYGELLLDQGRFSDAVEKFERAIELENAKPPPANVLPMVNKGLALYQWKQDIIAAEDCCQEALRIDPECEAAVATLAQLSLQQNKIEAAVDLFKRQADLARSEPELVNALTYQYASAAQIEFLHNFPDMASQLSQIAQNMAAAGGPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWQ4</accession>
    <name>A0A2R6NWQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v7341</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWQ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NWQ4"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="318"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR78594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="611" mass="68143" checksum="FF58DC7FB08CB5FA" modified="2018-06-20" version="1">MTKYIIVSGGVVSGIGKGVIASSTGLLLKTTGLKVTAIKIDPYMNIDAGTMRPQEHGEVYVLNDGGEVDLDLGNYERYLDVTLSRDNNITTGKIYREVIEKERRGDYLGKTVQIVPHVTNAIQDWIERVSKIPADNTGEEPDVCIVELGGTVGDIESAPFVEAMRQFQFRVGYENFALIHVSLVPDMHGEQKTKPTQTTVHALRGLGLLPDLIACRLIVQKPLEPATKEKISMFCHVSAEQVIGVHDVSSVYHVPLLLQSQGIVQYLHKRLNLGSIELTKEMKERGLDLEKRWRDLTGRQERLYDDVSIVLVGKYTDLQDSYMSVSKALEHSAFRCQRKLTLKWVNSSDLEPETQATNPAKYHDAWRAVVSAGGILVPGGFGTRGTEGMILAIKWAREQKIPFLGICLGFQLAVIEWARHVCGFTEATSTEFDGDTKQPLIIFMPEISKTHMGGTMRLGLRPTVFEAGSEKWSKVRQLYGGAEKIWERHRHRYEVNPEYLEKLSESGLSFVGKDERGERMQVLELPDHPYFVGLQAHPEFCTRPLNPSPPFLGFVAAASSHTVLRDQMNLQLKSFRPPHPVHAMVSEAELRHAEPTVPGEEAAIAAGEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX67</accession>
    <name>A0A2R6NX67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX67"/>
    <dbReference type="STRING" id="98765.A0A2R6NX67"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR78993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="18210" checksum="BE0CE8BD3F99C0E1" modified="2018-06-20" version="1">MSVTLHTTLGELKVEIFCEAVPKTAENFLALCASGYYDNCVWHRNIKGFMIQTGDPSGSGKGGQSIWGKPYEDEIRSTLKFNNRGILAMANSGPDTNKSQFFITYAKQPHLDGKYSVFGKAISYRSPAEASHVGRLRHRSDMPWAWLAALYRYHEHEKLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXI7</accession>
    <name>A0A2R6NXI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXI7"/>
    <dbReference type="OrthoDB" id="2757285at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="515" mass="57392" checksum="604BEB25E5EE65D8" modified="2018-06-20" version="1" fragment="single">MRLFTLQLVANVRRMSLLNKLIRSFPPSLLHGRRSQDALIVVSPKQHDGNQGLATELLVEILSYLGHRDLIKCRRVTFQQVIDGTPFLQYVVEFGVAGCTPEYSVNAGMTVSQRLRAFRAIQCTWRDPHPRCECSEYVLLPSSSAWNGRTSLAFGDILIGTVRGDRSGELLHILNLEAGPNSLRTPRFLDRILKFVADGEQDLLVLFSWTNVRFVSLSKSPEPHKRAAKEFINIGFYMSALHPAEIRSAAVSGDWVLLTTFRKGRSSFLLCHWPSGEILLKQSHSDVLSHNAHLVNGYLTICQNVLDPIFCRVVTTLEVYSPKIGHQTTNQVQIHPIARLEVPPVTLLSPDARHPVLRHIPSSASPGLVCLSLDGGCSGEWDLYVPLATVLSNVSSHTGTSFYVPWDAWGPFTRLASNKEPQAIINLRVVFNDMIWDFNPVDITRNIYAPDVVSPDVDGGVVHSKPTTLPTNANGKWSIPSYPYRETKLHLPRAGTHSGAWFKQSIFQDKVSGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXK1</accession>
    <name>A0A2R6NXK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000699">
        <property type="protein sequence ID" value="PSR79352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXK1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="14086" checksum="C16FCCF3ECD62A34" modified="2018-06-20" version="1" fragment="single">MHTAHLGLRLEEPPATAANEETQPTIPPAPATPVAPQIPPPPSVDPFANLSNEELLALWARVRHIAPDHGAVPPPLTNHRQPSELAPPLPAPLSSSNPMIADPAVIAQARALADSAGDAKVTALPPITPGFLATSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXM3</accession>
    <name>A0A2R6NXM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXM3"/>
    <dbReference type="STRING" id="98765.A0A2R6NXM3"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015342752" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR79249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="12831" checksum="61FA1210350B21DE" modified="2018-06-20" version="1">MQLFNWLSLFLFAFVVSAAEPPTELQIDTTFKPDDCSVTAKTGDKIKVHYVMGVGQVIRGWDEGLQGMCLNEKRILTIPSTMAYGSRGFGSVIPANSALVFDVELVGLESTGKREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXN6</accession>
    <name>A0A2R6NXN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXN6"/>
    <dbReference type="STRING" id="98765.A0A2R6NXN6"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="346"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="460" mass="52760" checksum="03C4A61DC45FFD32" modified="2018-06-20" version="1">MGLVPQDLKRAKESQRGRSPSSPTRRHSPSPSRDKDRDHDRYDRRNRSRDEDGEMNQRDRPRADDYFEGDRNGARRRERSRSVDRQRDKERDDRKDVGRPRRASPEYSEYRRTSPALEGSAPAPWRQPDNMYANRRENGSRNGYTAGGSDYMDSSPSPSRRHKKSKKRNRDASVSPSTDSEEERRHRERKERKKSSRKEKKREREHDREGRHRSRSVRKYSDDEESLGGRTRRRNRSRTLSGERHRSVVRSRASPSRTKSPEQLPPPSEDEDDWVEKPTTSVILSPTHAQSNNMGSMGPPPVPVTSSSAMSTSASAAIAMDDDSDDEVGPQPLHKASSSSKRIDERQYGGALLRGEGSAMAAFLKDGTDVRIPRRGEIGLTSDEIATFEQVGYVMSGSRHRRMNAVRMRKENQVISAEEKRGILKLQQEERERREAILREEFQELVNEKLKAQSGPKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXS6</accession>
    <name>A0A2R6NXS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXS6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6380" checksum="300B1BD9EB58E0BE" modified="2018-06-20" version="1">MDGAHSTQQPNRGQAVDFGFLPIPTHLYYAPQKAERFDLTRNIIFCIATTFGWSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYY8</accession>
    <name>A0A2R6NYY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYY8"/>
    <dbReference type="STRING" id="98765.A0A2R6NYY8"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="94760" checksum="F82EE6CDA836FB06" modified="2018-06-20" version="1">MDIFNRPPAISEDTLQYTLYPTLELSDKASVTTLAVLMQSYVDSMLPEMQWHRDAFQLKVSTNPDGDGFVLEGTMRVGDCVDDEWCAVWLLREISAKWDVAVRVFDSDGEFLLIEAADHLPAWVTPSNAENRVWIYNSHLHLVPLSHISAPSSKERRRGYPRAHADEDEIEQPDEEDFITASDAIKLLRDSLADTRASQDVENAVWHRIMGYPGAARAHVHYTKTYLPVDVAKALAVNPGLVQKAVETFYTRDALQLRAAHRMSRFPPEPSVPATVRMTRTAYAQLVGQKFYPPKIFPRWSEAEGTSEWRWRDVGMKIACGFEMLYQESKSRPSGANSQEAAKSFLEARKEALQRNPDYQKYIENLTSSGYFKGELEGSQLWNELAERAANAFVEARRDDDTNRPSFASQADAAAAKGNLASTRDLPEDSDEWLNVTAEDFDAMLEKSTGKSQSKVEQSSDGAMDVDTDGNIEEEEEKVAREQASRLKDLAKKVEDFVEGKGDVEGAVFEDEVLSDGELGDDSDDSDDSDDMATSDEDEDKDVQQVTRKEAMDRLVPGIDPSEYGKMPATFHSNSQRVAPTTVETEIREEKPEEGPDNQPYMRPIRPPILPRDEYEGVVDSDDETDEEGEGGGEDEESDEDKPQVVGEVEIDMEEEQDEFLEFARHALGVSDEQWNEIVKDRQSRGAFVPAKATIPINNSKTTTSPSNPPTEHSRVPRVPAPGPRPNVNPNLDSFEAVMQAMDAELARNRSATAQMPSAKTDKGKGKMQATEADEDDEEDIEAAMEAELKDVLDKGFDEDDAEIGGGEHMDYNLIKNFLESFRSQGGLSGPVSNLAGRLQSGWALPRDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZW9</accession>
    <name>A0A2R6NZW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZW9"/>
    <dbReference type="STRING" id="98765.A0A2R6NZW9"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR81763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="313" mass="34302" checksum="5404B271352C5530" modified="2018-06-20" version="1">MPDIAVGAQIFDLVFHPTESLVFTGLLTGEVKAFGYDEQGDHECKFSVKPSKRSCRGLTMSEDGSKLWAVGKGKTLHTIDTTTGTIVETRKNAHESQKLVVGTQLGILSIFNRRSGYGDCVDRIPGHPYSIDALCNIPSHYPNSHSTILTGSSDGMLRVVQLLPTKLLGVVADHGEFPIERIAVDRGGEGRWVGSAGHEEVLKLTDLKEVFEDEGDEEEEEQEEDSDDENAASTENDEDAQKAQSSDEEEEKEERNASDGEGGKEVKAEAESSDDEGAVERKRKKKDKDPFQITKKSKGRNGLEAEPSFFADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZY2</accession>
    <name>A0A2R6NZY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZY2"/>
    <dbReference type="STRING" id="98765.A0A2R6NZY2"/>
    <dbReference type="OrthoDB" id="3269227at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="229" mass="24708" checksum="FC60B3E238574714" modified="2018-06-20" version="1">MYKLIRRISSSFFPRADRPWNDDGESTSNAPQVGQKRRLGTPDLEDLPSPQSAKRLKAEKVDDDEHDTQGEGSSARAAQDSEDVKEVTKGVREVELEEGEAKNTEAAPGTAATVPLPASPELKPQAEESHEKDTVEGSSPQAEKDESSAKLGDDLEDESQVVPVQEGQLVEEVTKEAEVMSGMPQEITEDPPAVKVVGDASARVADEVEVLRKDDDTTTKAVDETEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P061</accession>
    <name>A0A2R6P061_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P061"/>
    <dbReference type="STRING" id="98765.A0A2R6P061"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="4">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR81319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="47302" checksum="7A270B9CDA60095C" modified="2018-06-20" version="1">MLKTESIDIEQATTHIQAQPDNKTRRYDRQLRLWAASGQAALESARLLVISASATSTSILKNLVLPGIGHFTILDPKKVTPADAGNNFFLNGHSSIGKFRAEEAVSLLRELNDSVDGIADLRNLDDILAKEDGREWIQSFSLVIAHNLDQDILDTLSQLLWENPTSPSLIVHNGALPKTYAEKQAFKANIRNLSQKLDEENFEEAEAQAFRLWSESPVPSDISATLNLPRLDQSSSTSSTAFHALLQTLRAFINSPESSGCLPLTSTLPDMKTDTESYVKLQIMYKEQAKGDNALFKTILKKEFPDLSIDEAMVDAFVKNAHHIKVLRGRRWGTWDKDPASLGPANITEEALRTEVQSLVGQGVELPEQLDDAIGEIARAPTADLPNSAAFLGGMVAQEAIKMITKQYVPVNGYCVIDLVETWTGIVGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P064</accession>
    <name>A0A2R6P064_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR82004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6P064"/>
    <dbReference type="OrthoDB" id="3040699at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1370" mass="147786" checksum="EAF15162F8245C86" modified="2018-06-20" version="1">MASNMNISNSSAPRRSSFNYHNPGLHEAEPSLAAVTMSKNAVYNNEKLFPLFRENLRGESVKTYEATADKLKIWLSKDKAYYDSARPWSALGTVIRHSGLQGEAPFHISLCPPGAKDWVIPYVTLVRAAANFHQYFPESHLRARLEALIRTVFVPPPVTTPSGPSMPPITPPEPFAGPSFTVIPQPQALYDENRMSSIPRISRSSSVKVKSETIEVPVIAHSCVPIANSSPSTVGHSQALIPSLDAGELANAKSSPDTYSLSASTHSSLPLPRRNPKPKHKSPMPMTGLEFLEEDLKWFQERNKEAIQEPQANATDTGAGTEDQALATKDEEKPPKVEEGQGLGGLLLWEQTDADHKQSQTASPLKVDQPAVSGARHTAPEPAATSHNTVATVISSETSAPVSAPPASGPRTSTPRTTTSETSKIVSPISLRTPAPQVDLAARALKSPLDVMKKAPKVKSNSLNLRIQPVPGPSARVAVPVTPSADIPTELHDPSADSPSALRSDSRPSPSMTPVEATSSNVEQAYTPPVKPKSRKGPPGIRTLPSTTPLSPVESSGMRQITPHGIASDESTVVQSPSRKSKGKKGPPGFKSFTELETASMPAMPFSPTSAPAFVSKNEAHPPFDVNATNISTRDDMKSVAKVSEDNAIAKEELAQLRASGKPMEQAKPASSPNVPIVVDDISEVNFPDDTAVFADKPKDDVLNPGVPSDVVDPTPMDIDETHVAAELTSPAEVELALRTPGADDDSTMRMEVVPPVEVANIISSQERDMEVEQLEVSQKVISRRSPEMARLHQHEVGDNENAPDSLAHTSTTASRDVLLAATLQVTTTTLTSTDVPMEPIEEAVTAPDVAHIDQNVASDTVPDVVAPIEGSAEILPSTPTEGAQVGLTNSLREQASDVVEEESQPVATTQEQIEVSTLSSVLTANTPPVLEGGLLDVVAPGDEDVLMSETTVAVQDQDIVVAVGTIPVGETIGTTRSESLGRLLEESPTSPSTGSTSDIRKRERSPSESDTVRSHRRRTLSPEQAQDNVAFPPQEYTVDAFARGNFVYPPTTNPEPEDGEIANQTSSPVQQVLGVAETITAKEVSNPNTQEERELGELTPMVSTKGLDQNFDVPPSPPPNDTHLKQIEVAVNSVPIVVGDNPVPTMSGPSTAGSSADVNDTAEQPLFGPDLVILGFMRGLERKEKVVFEFEISAEHHHVLTQWSRRYKIPDDMSSGKCLSLACYRFMDCVSAIDEDSTLSSPQKLFLGCKPTGWPYQDWIWVKINEPSADDTKMQFLVYPFSLNKDKLLDISGKIQIGKNRVEINDPYGDTFDYVFTLQLHTPTSSQLAELRKRRDAEQEWQDFVQECSKITIPPIVWPPEFGTINIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P123</accession>
    <name>A0A2R6P123_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P123"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14969" checksum="07BDFEC571B09B50" modified="2018-06-20" version="1">MLFSKNNVNSQVVQDEIGQNKRSEDQKAIRMCAINNLDVHGQSIAIYACRETLQVARLQGNDLYMKFASEFVRLVLLVLLLLVSSAWQEEEEVVVYLAVAPPLPELLEIQNCERHPQFRWLMKAEGLKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1J7</accession>
    <name>A0A2R6P1J7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000560">
        <property type="protein sequence ID" value="PSR83384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1J7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1J7"/>
    <dbReference type="OrthoDB" id="3253416at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="388" mass="43952" checksum="020D9FFF3244E07E" modified="2018-06-20" version="1">MVNTEPVGRRHAKKTKEVRAAARAASKEKENAYWKEVETLRKHNTTEISRVARQFEKTEKNVRLQLYRGGQLLVSKRKPSLRNAVLKDLAKQQKENGVSSDGRNTIINLSKSVSVEEIQALPEEEKERMMRALIEQRSETPAITKVNEVLVGRDIEHTMSRIEPEMEALSQRTGCHFMVLVLNSSVTDSWETRVFPSAEVKDALLNMFKLTPEDLALRLQAYLTTGIMDEVLREERKLAEKDLPKSMKWAYYEDLCCEFGVELVGWTEPGELCNPADMKTPALQRVLNSINSGQCFWRALSEDEWSSKRAARSEVLANEGGLRRKGRNGKKPAKSREIIDEEDEPVESAGAGEATMVGTERQEPAAHVERQEVERQSEAVLAFATINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5B1</accession>
    <name>A0A2R6P5B1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PHLCEN_2v5419</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000532">
        <property type="protein sequence ID" value="PSR85528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5B1"/>
    <dbReference type="STRING" id="98765.A0A2R6P5B1"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="20">
        <location>
            <begin position="226"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="371"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PSR85528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="416" mass="46933" checksum="028A07083DB98BCE" modified="2018-06-20" version="1">MFLLFGPLSRTLVPRYIRPPKHVSPLYSTRRCLATLSRENENINVVHSRFLAEGSTKAKWKNGSPATGSDGLDSAADDADHVSEGKGAQALMSDCSVLAMCGIASYSKVANEFVGKLSPTSSHLFKLIIPMDKLLLRDESHPGLPTVFLLHPSQPLSHISRLIASSLAPETPSISFRSASPHGKRLEWSDSTDVGDFIRDAARANVFEVHIQGNEERIVQIEVPTFEDRTRFLRRKLGLVERDLQEMDNLKKHCDDEARRGARRMAVGGLGMLVVYWGTVARLTFWDLGWDVMEPVTYLSGLSMVILGYLWFLYQGREVSYTSVLDRSVSTRRYALYESRGFDIDRWIELVSEAKTLRKEISKIAEDYDERRWTDQDDERDAKQAQADEEVKEVRETTKQAESSSNEADEKDKGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8K2</accession>
    <name>A0A2R6P8K2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000518">
        <property type="protein sequence ID" value="PSR87076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8K2"/>
    <dbReference type="STRING" id="98765.A0A2R6P8K2"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="968"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="993" mass="111169" checksum="9AE30CC449999693" modified="2018-06-20" version="1">MCFGENNATHAAYLFNAQLGAHWDIASQCLKRHGSPFKPDERYQRSFSLAQFRFGSHRDGSQASIEDMMFSASFRKPSLEFLCNHDAVLRLFIEEGHYNLNITRASDQSVADKASNRALKQVEIALRVPFSFKAIRGQDSKIGNGLHTYSVLELGLLDAVLIDTKPTIPDARPALTFYLSQYLQLLHNSGQTVLLSLPDIARDGFRTEIDFSIAASSSVAASSGNVFGIAVDDINEYLTSRWCKVSMLNIYSLGFPDANVGSIVEYRNIWTGKKSDVYFHLNFGAPRVAPLCDKEAVLYLSLDEVSFYPNQDFIGVSRTYNDWELAIIMSLVEIRGEGGKVTGAKFTFKGSRFVSGISRFPGFDSTNKDAVRHRDRVIEFISTEYLGILESVQYNIIYEQNTEVLTSEPDSEDDLQDDVGGDKGVDLTPWKIAADRGEMFGFDQIMTVSHSVINAHFQTLWAGNVFDNTNDASISRWTYQEFFEATFKPITVHFLSNGRAVILIRINEGTLKLFKNKQPWSQSEKYKFSTVQVAFEVDVKMSTHSAMPGVTSRWMTRFESSNAFKDHGKNSNVTFNHIYLNLQDAQFVRELSRFDSLFTSPDKYTIKKVQAILTYLQSYYFPQLVGSGYHVLSTIPVWKSGPTLPPFALTSVTFRIHSKTEVTRMTYTNTKSSSQPVIVILGMAGGRPFPEVPVLPEWIVRPTKTTYHGSINISGRAFLDRLLQQFSQVNATTTIVPIFDGIDDEGWKLELVTWDKHPTKRRRAPKFVPVKGKGDEKWLRYRWQERDVWTHEHEGGGSLSAGAFGVSCITKNFLEIPLTCDGVSDALDIKVSGEIEFGVSFQGTSQKWSSKSSARWDATFSLQSSIEGLHVEILGSPVPEIAKAVVEGTVPANSEGVIPEKLFRNFLLSNTADFKGVLDVLKIFESSWSSCYPGLSTFTLSQPVFTRKGDLLFTLQPFLAVQQIVSPAAPASPGVPRSPVVDPRSRMKKRQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8K3</accession>
    <name>A0A2R6P8K3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000520">
        <property type="protein sequence ID" value="PSR87008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8K3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10386" checksum="75F837C3CAB402DB" modified="2018-06-20" version="1">MLVVVSECRIVLVEDVVDLRKRGGLGVHKLAELTARTPVSTATERRIQGETTCSSSLINIMRRQNWKECRGHFCQNVVGNRLAQLAQVVKVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8M2</accession>
    <name>A0A2R6P8M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000519">
        <property type="protein sequence ID" value="PSR87074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6P8M2"/>
    <dbReference type="OrthoDB" id="3259294at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="251"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1148"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR87074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1956" mass="218980" checksum="C4558901A9DB2CB7" modified="2018-06-20" version="1" fragment="single">NGSWLGDVPDQLNGLNYIEKMMVARFRHNACVATVNTAGRRMHANAVVFAQPVAKLYNVLPPSPAELSEVIGVYFLGPCAPTETDFKRTPFLIRKHVVLRALQWLKVNHQDYGDLQISMENLQSYPEDQPPVGWYHLPDQGDFPIASLPVYETSADERGTESGSCSFAVHGICADDIAGMSKDALVAVALRHLKGKGEVVGYGHSSQPESIYKNPRLYPGMFPWLFPYGLGGFENDLALVGVPRATRVRQLLYYHDRRFQVDETFPFIVFNQDQIKSCSRGGFVLTDRRNYDEVVEKILSVDVNVLSELVRRGKENGFVQPLNDAEKRCYELISIIDHVAGHVPGSNTRKKYQRSEIRSLIIRYGIPVFFITFAPSESKSPICLYFCGEGIDLDDYLPLKTDSKERLRTVVQNPVARARFFNLMVNLFVKHVLRADSGRDGLFGRTSAYYGTVEEQGRLSLHLHMLLWIEGTHSPQEIRDRSLDPDGTFAKALIDWLENCHQGDFTTGSQQEIEERMKTKGWSGREPMSTRPWWPDPTTALPQPPPPMSTEQEMDSWFERMCAVTDEIVALANVHDNKHNKGCTRPPFNECRARFPRPLNEHSYVDLESGALRLKKGEAWINTFSVVVTHLLRCNSDVTSLLSSTQVRAVIAYVTDYITKTNLKTHTIFETIQKVLAGSASIIADTPSRADAARRLITRIVNALTAQSQIGGPMVCAHLLGHPDHYTNKTFKVFFWMSYTKAVGSVWEINTSDPGAPSNSYDKELWVLQNQGGKVVGHSKVFDYAHRPREFSNWSLYDYIEQTVVKRLPTGGSQRHTDPVNYEQTEDGVPEDEVDLDTSSRKLTAELQPGRAYRFDIKHPNYNTHAVHLVKPECRYVVNFVGPVLPRKDRGDREHYCQAMLTLFAPGGWRTGLELKSVEETWDAAFSRTSFIPKHDQLMRNMNVLYECQDARDDYTAQRRAEGKRKFLATFLDDEVVDALDRETADSNVTDNITNQRLQSLIEQMSTNLNDHGVRTRKRMDEMRSFILHLHQPTLPSTPSSAVTVPSPCAVPVKTPEQWRSLVVAAKDVVMQARRDHLVNVPSSVLETHPLSFPHTDQPNEEGVVKLLSLNQLDSVRNHSSDSGLASAPDLFRDCAGHIESVSTRFSLNADQRKAFTIAASHLISIQNEPLKMYLGGMAGTGKSQVIKALSTFLEDRREAHRFAITAPTGSAASIIGGSTYHSLLGILKTGDSGSPLTLGKVKDRLAAVDILFLDEISMLSCSDVYAISSKLCRALDRPTQPFGGLHVIFAGDFAQLPPPGEKQLALYSCSTGLKSAGLSTSGQKNALGRGLWHCFTTVVILRQNMRQRGASLADSNFRSALENMRLKSCTSEDIRLLQGRILGPSNVTRLTDDRFRHVSIVTAWNTHRDAINEVASEIFATETGQTLHHFYSQDKLSIKCHADSLRELLRDAESDLQLLTKGVIPPKLQEYFWSLPPSNTGNLAGVLSLCLGMPVLLKHNEATELCATNGAEGHVVAWDSQRSSNGKDVLRTVFVRLHQPPRDMQIRDLPINVIPVPSTSKTVLCTLWSGRKERVKRTQVFLLPNFAMTDFGCQGRTRPNNPVDLRHCLGHQSVYTCLSRSSTLSGTLILHSFDVKKVTGGAGKDLRREMRELEILDDITSKRFTGTLPLAIRGVFRAELIKTYQNVYGPRHVPSHVHPALNWRKDHLANLTPPDIPDQWRQVHPSGFNVENNPKVYAHETVLSAKREAVRAVHKVSTVRQTLAEQLLCSSSAEVNVSSNKFASKRKITADEVLLSAKKLNTTNYQPNLQTTRPTPPSSTHGQRLGFAWDSVDHSCAYDAVFTIMWNTRESGLTYAWRDLVLESTFARHLEDSFGGVTIAYTQLETVKGYLRDILSDSSPVLFPRHGPVMTAIEPLLDAPICFTSTIIRLSACVFVRFFQSSQLPVLRGDGLLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC80</accession>
    <name>A0A2R6PC80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC80"/>
    <dbReference type="STRING" id="98765.A0A2R6PC80"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR88885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="100" mass="10601" checksum="F35D04E089F17EED" modified="2018-06-20" version="1">MAAHPKATPLVAPGHTRPVTHLSFSSLQDDGTYVLISSCKDGNPMLREWTGDWIGTFLGHKGAVWSSKLSPDTSRAASGSADFTAYVLHLPATSRTMACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC83</accession>
    <name>A0A2R6PC83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Blue (type 1) copper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC83"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015345636" description="Blue (type 1) copper domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="5">
        <location>
            <begin position="48"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR88904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="22807" checksum="7F21E5787166AA0E" modified="2018-06-20" version="1">MMFKALLAFSLLPLAFSSPQVYGGPVAAPPPATTSSAAASPSSSDIVVQVGSGSTGIAFNPSDIQAPVGHTVTFSFQASIQHSVTQSTFADPCTPISQTQNGTTGFDSGLTQGTTFTVNITDASTPVYFFCKFPTHCGLGMVGSINAPSSGNGSFASYQSAAMAIGSNEKTIPDAGPQTGGVGAVATAGPQTGTPTDAGSAPANTGSSGAAQLSINGVMALLSLGAAVAFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN24</accession>
    <name>A0A2R6PN24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN24"/>
    <dbReference type="STRING" id="98765.A0A2R6PN24"/>
    <dbReference type="OrthoDB" id="2529242at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015345647" evidence="2">
        <location>
            <begin position="16"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR93793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="877" mass="93335" checksum="9131F5D18E22193F" modified="2018-06-20" version="1">MLFTLSITLSSPLLALNILLRSPLPIPSGLFDSPADPPSVVMRAPSPLSLAPSYAHSYKRSGSVTVVEGRRSGDVWISNGDAVEGKSKFGRAVGLLQPKPKLAVLPSGCEYYGPPLTPPLPIQDPEAEEHERTVPSTPQSVNNAELGVGMHHPEVLAKEDRGDDDNHVEMGMRKKDSKASSYWSGTDENVAFATKIMVAQKHYSTLAMTMVLPPSPQRRGSQEVNPGAQTAATTTAVAAGAESAAGKRASGSNHLRARSVSSMSPISAPPSSPLPPTPPTIKTMLKLTAAQSYRARTTSQASGGNPHNHNRGHGKLTHRRSYSSISSFPDLGLSEPAAELGGFINHHNNDYSFGPIDHDSLNEIDALSAGLLPLLVPGLKVGGEMRITESWKKAPSTTTTRFGNYQMGGRRNLGADAEVPEELGGMVSSDFESPQMHSTPHTRKANTQTPRTKKTSAHKRHHFSLPSLSLGKDGIHALSTWRNDLNKALETKGTSTSQYSAVPTLNVASDDVSSDRRNTVLGSDFISQLHLNAVREDDELAFSSRPAAAAAVVVVDHRYSTGFKSDTLDVPEGISTARNSMATLISALDQELNMPPGASASVPTVWQGVVPSSAASDVTLFEFNPSVEGLAESTPYDSNKVLPMGGSGRSRSGEDRAPPPVPEIPKAVKASRRSSIVYIKSDSTTATTGPIITGTSSSLSNKNNNDTSLVVSPKGGLAGWSSRAVAPLMPKSKASKLQLKASKMSRRSENDPDSAQAEAAPAVRELRMGGLRPLSLLQDRQNTANAAAAGGGVETRPLKLGKGSSKSSRASARSSDENEPPRTRESSFKKSLRPLKLARNETTKQRAVLREREVLPDVVVRPPSNGHHVGYAYDFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNG2</accession>
    <name>A0A2R6PNG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000452">
        <property type="protein sequence ID" value="PSR94366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNG2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11504" checksum="77C7AF498B7D9FE6" modified="2018-06-20" version="1">MPEMAPCGAILDRLSRWSRLKFDACAKCQVRRPATRPHFQAIVLTLCVYAPPPCAHQNHQLPSKFPPPTIPRHLERLMNTFPRLAVSINVSLFTLVAYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVD5</accession>
    <name>A0A2R6PVD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000438">
        <property type="protein sequence ID" value="PSR97386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVD5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7241" checksum="FEE6091D67F6B77C" modified="2018-06-20" version="1" fragment="single">EHNIRDIKLNSADKVEDYMAKGADLDLLRRSISNWAKKRMIKSSNEEDWASDSDSETVAMIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PW60</accession>
    <name>A0A2R6PW60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PW60"/>
    <dbReference type="STRING" id="98765.A0A2R6PW60"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="180" mass="19756" checksum="10359FBA66ACBB96" modified="2018-06-20" version="1">MSGLLSRWTVGSIGLTCKAFLNTGYCSSVTVNGLENLQEALYSEERNSGRGVITGFEKLMPEGRPFPYKYFPKRGVKLSVTFGKPICDEDVKMALSHTIESDELSGVTSSELSLGVPREEAQSRATSESGWLGKEIRHAEQEGETSEEMSRKTARIRSAVTAVLHRNVEALGRQVLGLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYV9</accession>
    <name>A0A2R6PYV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYV9"/>
    <dbReference type="STRING" id="98765.A0A2R6PYV9"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR98917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="34732" checksum="C7536C366C130F27" modified="2018-06-20" version="1">MHEASYDLPTYPPHNFDPYTLSSRDFFSPTSNIPTYMASPHGHSTYSNLSSTRLFNGYTGTGLGGSFGGDAALYAHSSIAPLHASSSTQRHSQLQLQHSQYKPLNTWSPPRPSTSATTLPSSSTLLSAPTSITSSRRDTRRSPNGEAERAPQAAALYEQSQIPPSSLMPSRGGTYGTSTQPRLPMIIPVEKQQVTTSATQAASASRRRNEAHFSCPVPGCTSTFTRRFNLRGMSAEPFFNRHFLTVRHFLQGICDLIRKSGRSYVNGQVAIKASPASTIAIKSDGGAECKSTAEAVAIAARLSPNDDDWENRSSSTDARGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ07</accession>
    <name>A0A2R6PZ07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ07"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5676" checksum="88F1D4BDC3D26DDD" modified="2018-06-20" version="1">MECFLNNDEFMPKVVGVLHAPFKANSPQVAKEMWDVARLVDHEDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2C6</accession>
    <name>A0A2R6Q2C6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000405">
        <property type="protein sequence ID" value="PSS00872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6Q2C6"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="1237"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS00872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1516" mass="162722" checksum="A6FA4ABAB9653EEC" modified="2018-06-20" version="1">MDANELGRWTRFAAKGGIGKCSAVQDCVAEEAEDLMFMKVRRFTFTLQHYSAASISVTEDLSTSTSTSTVSSPLHHYSSPPLPSSPHLPAPPSSNDESQHIRSASHSSGSTALDSAPRTPADFNKEDSDDLIRVVSLSRQVASPTDLHRDSSIRQESSGAMESLVITAKRLSLTETAPLRITRKDTVMQEDIRPLEHDEEPASFLDSEPSTRISVAMSDGEVGIGLSLLQDFMGGDIDDTVSVRSSKSGMRTPELRNPAILETTASPASTLEGNAASIRSLAISDRSSIYSTASHQSTYSQIPEDAPRQRSNPTSPRDAPSRASMHPSISDSDYNGEEWEGASDIYDNYRYSRYSMASKASRFSKGSMHTVASAFGLEAPPPVPVDSNRPSLDSLRQGSFSRERLGSLTATSASVEDVRGRRSFDSSGSFSSPKDGSDAKGCGSEGKRIPPPLDISPSHRHKQQSVATISPESTTSPLLHGTFNSPLTSPTQHSASYLSPLSPPLTTPFYSNAPGGAASALRHRLEQNGTSLTDTPVDEASSIDSQVGERSRISSQPIVVDDADEPARSPPGLTPTSPSAMSSSPPPSPSYISEKKRMLETTYIVANQAPPPPYTPMSPTAGSSSQALPEEVQAQPQQQPTQPFSEPMVQPTPRPVNPERQNNSFARRSMFMPHPHAPKPAETPSGPMYGRQAPHQAPQGYQTGPPPGSAIYTLHMALVMRGDPMRPRQMTIYGRFELDLSSSIGPVPVFFTLEPPNNIPANRFRPPTAPSSPAPSEQPGESADYFMMNSSVTPPPENGAGKAIPRANFFPKVKTPRPRSRSFSGFDSSAAEVIIPTDSSANESGQPIQIPSLNAMAKRSKSAHVSSPSPASPPPASSSSPATSGVASAVRTAHKPSPLSLSQNNVVATRSPTSAPPMSPTRPPPSPLSYSMARSPPRSPTPGSPTASESKISLHMSLGQASSAIGSPVITSPPLPSSDLPTARPVLRKISSSSIGNPATASSPASPTNHRPSRILRHSRSSTLSNRPSARDPSPHSRTSMQGRRSGETDASHQSEAHSGSPLLQTSSLRSKLSLPSLKIRGSERPVQYEERSPTLSLTPSEHSDQPMVNVKDMNFELVKPVGQLASIIEDPLMPPPLPSPNRLDGGSLRADSPAFSMLSGMSARTGLTQSSVIETPRVSVAGTTGTASLLPLSKNVDTQTVEAHRQRELRWISMISSIPASQARKNKKVRKLLWEGVPASVRYLVWAHLTDSKAKRMDGLYGKLVKRDRVPASASIERDVQRVFVHEPQLLDGSLVNLLQAYLSMVPDVSYSRGLTVIAGDLLLHSPEEDAFWTFVSLMDSHLRPYFSAHGVQMEVDASLFGKAVEAADPNLAKKVFVDMAIPPASLCRPWFTALFMEALPSEHAQRVWDIFLFEGVVFLIRVGLAIVSCCKQTVMTTAGRDAVLNTLLHPPSACLPTNADTFLEMALNVKLKDDDVRKQRTKLEAQVKKQTQARNQNQTAIASGGAPPSISLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7J1</accession>
    <name>A0A2R6Q7J1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000382">
        <property type="protein sequence ID" value="PSS03720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7J1"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7527" checksum="A6695C9E6554C89E" modified="2018-06-20" version="1">MAEFETYHNQKIEDFQSLTTDYLDGEIALYEQAANDPPDIPIAYVRHTRRLATPAVDLRTRTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7K5</accession>
    <name>A0A2R6Q7K5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="8">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v3968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 8">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000383">
        <property type="protein sequence ID" value="PSS03714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7K5"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7K5"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015361181" description="AA9 family lytic polysaccharide monooxygenase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS03714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="330" mass="33747" checksum="9757A5113E0B67FC" modified="2018-06-20" version="1">MFAVTALLALASSALPTVLAHGGVLSYSNGGKWYEGWAPYNTPTGQSTIQRSWSSYNPIQDATDPTIACNDDGTSAPLQLTATVAAGSAITAYWNQVWPHAIGPMLTYLAQCPGTTCTGVSASTLKWFKIDEAGLLSGTIYDGQWGDGQMIADNSSWTTTIPSTVPSGNYLIRFETIALHSMPAQFYPECAQIQITGGGSLAPTAAELVSFPGAYTNDDPGLNIDVYSNAAQAQTTYVIPGPPLYGSAAASSAPAPPHSTASVPVSSASSTATHPNSSSAPLPSSSAVAGTVAEYGQCGGTGFTGATACVAPFTCTALNGESAFLCQDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QES6</accession>
    <name>A0A2R6QES6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QES6"/>
    <dbReference type="STRING" id="98765.A0A2R6QES6"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015316723" evidence="2">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS06576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="164" mass="17798" checksum="E83560A5B1975812" modified="2018-06-20" version="1">MASMALFFLMLCIPTLASASYNDERGPPPHPFWRRSNVPPQGYFDPKDNGGSLLTQVPGTFPAGLGEPLNVIMSANSDSDVLKDQETDGGLRNYFLSLGYSSECLGQHLGDDQGANLGDGNGYLNETAVIRWDYGDAQLGSCKETIEGGAHFRYWVQDGSKADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIL1</accession>
    <name>A0A2R6QIL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIL1"/>
    <dbReference type="STRING" id="98765.A0A2R6QIL1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS08843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="465" mass="50494" checksum="A60D9FBA97ECB0E1" modified="2018-06-20" version="1">MSRVGLSSASRRRTESATPPPALASARSPSIDIRSSQRGRHVADYTPPTPVSELPEPPDTPPPLESAYVACMAGSVSSHSSRRSTPELSSSSSPTAPTVALHPSSRVFQPHSPEASYSGLHDRKPIAMNYAHGVHSYHRGYPGPDKRDEDNLSSPTESAAHPYNDIDDAPSPSSSAGSQQQPFSQEAGQSCQYRYQSHYAASPGLSQFQAFKQEVPSNDAVSRQPPPTYPSYTASSPTHPLSPLLSQPPSPTYARSPSTTHAAGFTPIDHTTTASLHQDSTVMNTNYSSLSMAGCLSTSTPTSRGNHQIGGHPNSPHSQYPALPSGLAQNYTHMQSVHGESQDPASPHCRFPSVVLAPIQRDHFLRDENSRRSLRRAPSYNTNDQHHHSVSHHNDIQAHDIDNDSRTQSLAAHYPGMHQAQAQLAHRSQAHLPQYAYTYSSPSNTHNSSTAWRSDLPRERSMLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUI1</accession>
    <name>A0A2R6QUI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000308">
        <property type="protein sequence ID" value="PSS15415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUI1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS15415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11678" checksum="DB1C519357B164AF" modified="2018-06-20" version="1">MERQGAIGRSRSVQVQTVPLVRCRHPRNLHGISERPFCPHTSVNGSIYFRRRTEPESFFTSLTILAMGAIVDYARVDLEKPVDDCIADEIRGKSAHIAATGRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RII8</accession>
    <name>A0A2R6RII8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000250">
        <property type="protein sequence ID" value="PSS29846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RII8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="9033" checksum="1C9A1AA9E54D157C" modified="2018-06-20" version="1">MSLDTDVSQRQTERTVRDGRAFGRYGRRIAGKDSMRRLTEDDVLMVTPRGRDGCDEELEGVKIVNRGPDDQRGIKIHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIK4</accession>
    <name>A0A2R6RIK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v2644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000249">
        <property type="protein sequence ID" value="PSS29851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIK4"/>
    <dbReference type="STRING" id="98765.A0A2R6RIK4"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="76"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="223"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS29851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="326" mass="36863" checksum="D8C5A6A4C06A4A27" modified="2018-06-20" version="1">MSRTKSAQAGPSTPNGMVYDPDQNAEERRGVRKGYRDVQRDLEDANSANAETLLDVVHKMDELFEKVKGPGEATLDSSALMAASMRHAVLARSMKSGGGSFDVDDFVSKLIIFMGGRHSVEEMPEDDEYDDNDDGNGAPLDWERIGWKAVAKSHRVPVMDFMLGPLSIEQKQRAVGKRSKLEKDKGSHKKPQELTEDDITRSENETTKNVANLERILEEQGKPINLFRFIINPNDFGQSVENLFYLSFLIRDAKCSLDLETGEPILMLCEQPTADDYDGGELKKHQLVMELDMPTWRRAIEVFNIRQSTIPHRPKSEMRIGEKWYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLS9</accession>
    <name>A0A2R6RLS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000230">
        <property type="protein sequence ID" value="PSS30972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLS9"/>
    <dbReference type="STRING" id="98765.A0A2R6RLS9"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="24525" checksum="1E2A3B53201C5422" modified="2018-06-20" version="1">MGELFTQYINGENSDVIAIGKSTLQNDGTVISWLSKGLQALNLHVPFKPREPISPIKSITIGDFALAFDPGTSWTPSAESRTVQAFMALPFGFNVSIGQIQNDLNITQGGMAVAGLATPIGASTSNIKVNNASDTSGMIDIVIQNTNLSCPASQHPIFSSFNAALTNQKSAEFYLVGNSKAVASMSIGQITLDPIKVNVSTQLLGLQGLKGLTTIDSVDVLGGTPDAINLGISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLW5</accession>
    <name>A0A2R6RLW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000222">
        <property type="protein sequence ID" value="PSS31020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLW5"/>
    <dbReference type="STRING" id="98765.A0A2R6RLW5"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015347555" evidence="1">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7542" checksum="6815660486524A7B" modified="2018-06-20" version="1">MLELALVLTTSWPVYSGADPVVVTRAREEADDDLEERVGNAIEVAIISQAKNFIKTLPCQKVVDGIWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM02</accession>
    <name>A0A2R6RM02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM02"/>
    <dbReference type="STRING" id="98765.A0A2R6RM02"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015324521" description="Cupredoxin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS31042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="20078" checksum="6AEBD2DC3816DD14" modified="2018-06-20" version="1">MRFSTFVAALLPVGAVFAETWNVTVGGNGTLTFNPTSVNATNGDTIAFTFVSKNHTVTQSSFASPCTNLTTTAGETILDSGFQFIQPNATSFPVYSFNMANATTPLWFYCRQANHCQQGMVFAVNPTAAKSFAAFQAAAMNSSSTSAPAASGGAPSTTPSASGSGTAPPATTSNAAGVIKAGSAAGLLLTGAGLVAGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPM4</accession>
    <name>A0A2R6RPM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS31980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPM4"/>
    <dbReference type="STRING" id="98765.A0A2R6RPM4"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04194">
        <property type="entry name" value="GT8_A4GalT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050748">
        <property type="entry name" value="Glycosyltrans_8_dom-fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778:SF13">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE-LIKE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13778">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 8 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS31980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61267" checksum="CE3484F1FB177AA2" modified="2018-06-20" version="1">MSNQTKEPVVAPASYSAAEREPQYIFTETQDWFSHNIDTWRSFLPHVTSPAPRVLEIGSWEGRSAIFMLTELCGSRGSLVCIDHFDLMKTEAGRKRYAQLQHNLTLTGKPFRVVSEFSVPALMSLLQEAITADDPGFDWIYVDGSHRADDTFLDGELAWRLAKKGAVIVFDDYLWDQEPVESIHHPKRGVDSFILLHAGEFEIISSPDSYQMVLQKTSEMRIGFLMKEAESVPSMEGFDHGMHVALVVDSSYAMPAAVAIRSTLVHTGGRITFYVVDLGLSKDDKDRIEEVIRLFPNATLRFFQLPKESLAADMGLVWAKIDMISVLPVERVLYLDADILVRADLRDLWDTDLQEKAIGATVDVGHPMGHASVQREPYFNAGVMLMNLAKVRLNVAALESTARKMKNFAYMEQDALNVHFRDDWCALDLRWNAQGLGTYANCPSPERDALNLSTMGEGAIVHFTGPVNPAMEDVLNPHVQPYTSKPWGYAGAPGHPFREEWWAALDQTGWKGWRRSDEHSAYCLAKQHEASKVGVTTFSARVLEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPW4</accession>
    <name>A0A2R6RPW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v2170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000201">
        <property type="protein sequence ID" value="PSS32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPW4"/>
    <dbReference type="STRING" id="98765.A0A2R6RPW4"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 10" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="11715" checksum="10FA6025BC9BFE3E" modified="2018-06-20" version="1">MPFSAGDSGKGASLFKTRCAQCHTLGAGEPHKVGPNLHGVFGRKSGQSEGFSYTAANVNKGVTWDEQTLFEYLENPKKYIPGTKMAFAGLKKDKDRNDLVTYLKEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ45</accession>
    <name>A0A2R6RQ45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v2093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000195">
        <property type="protein sequence ID" value="PSS32137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ45"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ45"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSS32137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="156" mass="16707" checksum="C963BD631D209771" modified="2018-06-20" version="1">MAPKPASTAGKAPASTASKAPAKTTESKAAKKTKAPATGADGEKKKRRKTRKETYSSYIYKVLKQVHPDTGISNKAMAILNSFVNDIFERIATEASKLASYSKKSTISSREIQTAVRLILPGELAKHAISEGTKSVTKSFVISIIYISGLFLESKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVH0</accession>
    <name>A0A2R6RVH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVH0"/>
    <dbReference type="STRING" id="98765.A0A2R6RVH0"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="34"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="446" mass="48715" checksum="6CBFAC70373CD45D" modified="2018-06-20" version="1">MSSSLDAKLGAALRSRDERQIRRRLSDPDADAGLVDFHTNDYLSLSHSPDLRARFLSKLHVAPEILGSGGSRLLVNGHAHSALEARLANFFGSPTALLFNSGFDANVGFFSCIPQPGDVVVLDEYIHASVHDGVRSSRARDAQFTFEHNCLTSLGDVLLRLLHARPGLSTGENSLFVAVESLYSMDGTVAPLSQIVEMLETLLPNGNGYLVVDEAHATGIYGPNGKGLVAMLGLEHRVLARLHTFGKALAGSGAVILTSTLIRDYMLNYSRSLIYTTSLSHANIVSVDCSFDLLEDGTAKKLSSHLLQLSTHFLDTLRTLMQTHVIPAHLLSLPSHLSAPPAVEPIALLAPVFAYLPAPIIPVFTSHPRPLSAYLRAKGMNARPITWPTVPKGRDRIRVCLHYGNSRLEVEDLARAMVEWAREQIGQQRMIDSRLPHQEVLVQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVM6</accession>
    <name>A0A2R6RVM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000158">
        <property type="protein sequence ID" value="PSS34079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVM6"/>
    <dbReference type="STRING" id="98765.A0A2R6RVM6"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="12895" checksum="6C4C00CA5E9C73FE" modified="2018-06-20" version="1">MRQLLEKYPEYKSNGDKGVRLVLVGGSRNTEDAARVNGLRALAEQLEIDSYVEFIVNASYPEMLGWLSQSSVGLSTMVDEHFGINVVEFMAAGVIPVTHASGGPLNDIVVPFNGRPTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVT2</accession>
    <name>A0A2R6RVT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000151">
        <property type="protein sequence ID" value="PSS34127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVT2"/>
    <dbReference type="STRING" id="98765.A0A2R6RVT2"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="65"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS34127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="462" mass="50421" checksum="F9D027A855A72E3B" modified="2018-06-20" version="1">MSNETNQRIFTGNNVLLPGAKQPQPATIVVDTVTGKIIDVKDGLSARDEFPVVQDSDWIDAGDKFILPGLVDAHVHLNEPGRTDWEGFWTGTRAAASGGVTTLVDMPLNSIPPTTTVPHLTQKREAARGQCWIDVAFWGGVIPGNQAHLKPLVIAGVRGFKCFLIESGVEEFPCVTEGDLKLAMEEIRDTPTVLCFHAELEKSHTPAPIETSDPTLYSTFLSSRPQQLEIDAIDLITTLHKQYPSLRLHIVHLSASDALPLIRAAKASGLPLTVETCFHYLTLSSAHIPHGRPEFKCCPPIREEPNRETLWAALLDGTIDCVVSDHSPCIASLKKCEEGDIMSAWGGISTLGLGLSLLWTEGKKRGISIAQIVEWVCVKTAKHAGLDSRKGRLSVGYDADLIVWDPEAEFEVTKESLNFKNKLTPYEGLTLSGRTEKTFLRGNLIYDACSAGFVDSPQGILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZI1</accession>
    <name>A0A2R6RZI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000135">
        <property type="protein sequence ID" value="PSS35379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZI1"/>
    <dbReference type="STRING" id="98765.A0A2R6RZI1"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00006">
        <property type="entry name" value="COFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS35379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="143" mass="16153" checksum="3AF2C653C665529B" modified="2018-06-20" version="1">MLIIDGGQSSGVGVSEECIASFQDIKSHRKFKYIIYGLNPTNTEIIVLKASNETDYDVFVGELPGNECRWAVYDFEYEVEGGKRNKLVFYSWSPDEATIKSKMVFSSSKTALRNSLGLSTEIQGTDFDEVAYESVLDKIRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3A7</accession>
    <name>A0A2R6S3A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3A7"/>
    <dbReference type="OrthoDB" id="2845803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="15335" checksum="BD439569BC4EB387" modified="2018-06-20" version="1">MLPTLYDWSVEHIKNVFEAKSEDECLRAIHATFSQNIDFSTNGKQLCQLDLQRFILSMVSGSGFRLKVQWQNALEVPRDDTNRDGVLGGYYIINNVRKTSTTGAPTPGRFARHKFVNVVYVDTQVSQRDFKLMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3J7</accession>
    <name>A0A2R6S3J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000102">
        <property type="protein sequence ID" value="PSS36833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3J7"/>
    <dbReference type="STRING" id="98765.A0A2R6S3J7"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="124"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="195" mass="20641" checksum="26A34FD9A8520709" modified="2018-06-20" version="1">MDIQCGECIWTPTNDKVSNATGGDLAQLVAWQAQMQANVSRLNGVVVPGETGNAGQEDQGAVQQLQHISGDGEPSVCPTNANKVAGVLSAANPAMLKDDQFHAFDIICWHLNKTLAGKELPLLWMILYGEGGTGKSKVIQTVTEDFAAQGAHGLLVKVAYTGVAASMIDRKTTHTIAALTVKRRDTQTLDIPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3Q7</accession>
    <name>A0A2R6S3Q7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3Q7"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14323" checksum="CA1B9DB2541128C4" modified="2018-06-20" version="1">MPRTPPPNPDKRRLPEGWIEQYDDQFYTNKGVYPNQSSWLHPYGPPPSPPPAPPPAASSSATIKQEAEEIKLTTDNKSTENDYAKVKAEVKEEVKVEIKEEVKDEVFASPVGLVFLELRSIFGAGRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S472</accession>
    <name>A0A2R6S472_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000083">
        <property type="protein sequence ID" value="PSS37090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S472"/>
    <dbReference type="STRING" id="98765.A0A2R6S472"/>
    <dbReference type="OrthoDB" id="2692094at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="225" mass="25548" checksum="980C9596BB474701" modified="2018-06-20" version="1">MLGAKLHHLVNNICPHYHTKELTGEEAAHGRHRAAKSAKATNQPATQVGTAVSTQNRVQGPKRKLLNLCMYKLHALGDYVLQILWFETTDSYSTQTGELQHCRVKRFYAQTNKNGTNIQIAYLQRHEELLQHKQAQVHKHPLSKKAQAKVQAALAQDESEPLAYTPPKDHHHISHSCNFTLKLVPFLREHATSLAIIVGILSYTMHWQSFTSEYRASERNSKTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4N1</accession>
    <name>A0A2R6S4N1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4N1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="78" mass="8891" checksum="E0AD9054F97D5B52" modified="2018-06-20" version="1">MEWWGGETGERCHTELIFYKHVNSSSEMDDNEDVREEERVWWGCSGPVPPRMEGEGGEGEPDPHRRLSGSREGDGDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5K5</accession>
    <name>A0A2R6S5K5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5K5"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="314" mass="35025" checksum="CC05531DAFFDE412" modified="2018-06-20" version="1">MSKPYQPTPEQLALAEERRLKKLLRKDNVEKVVQGEILPRDWLTFLPSPDPLRTVKIMSWNEVDRTEILFPILEEAGYGCVYTAAPRKKHGCAIVYRKSAYEVCDARTVFYDNEAIRDGESDRFRRGSSFYTKNIANIVALKRTTDDNDGIITATTHLFWHPKKFNSAVDFNFQPDDAAYSLLVGDALLPAQSASLQSSRVVHVTIDPTVLVSSGATAGDEEGAESVPDKVITSARAAKPEDGLLSDVELTKFFERADRPVSAYDKGLRSQDPKLANLGLTFRDGPNRDFAPGRHGAFEPIYTSYTHAELLGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5M9</accession>
    <name>A0A2R6S5M9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5M9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="8396" checksum="EEEBE0E551945D92" modified="2018-06-20" version="1">MTVRAAGKIEARVYQPMTSAACEDRGDDMGTDIADIGGEPMPPMDVGEEDPWSSKDELSGRGAPALPAMLASLEMGNTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5W3</accession>
    <name>A0A2R6S5W3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5W3"/>
    <dbReference type="STRING" id="98765.A0A2R6S5W3"/>
    <dbReference type="OrthoDB" id="10261361at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="385" mass="44403" checksum="38DFD8A0E701499D" modified="2018-06-20" version="1">MAICIKPIGSRRPLLCCCPGRRYHAQTSIHYRACIFRLKQHDLLTWEGLRLGSGFEVELTYAKSVVVDGSVIGLNDDFDLTPSLARFLTLNEELIPNRLARFEEILDSYQNFYRLECRAKAETLSYQFLAFVYNTPCGPAEVAEYCAKAEQDERVQRLVLASERIFRVSYERLLVASATELNTWWYLFWDDLWRRNHETVSGLQKYASDFDPHYPTSVAYKPLPRAALESFLSQRGLLHKKPKWGDFFHAGILNKVYLRMNDISFHGTRRADIIHLGGGSLEFDMEEIDDRTLAQPSSLGTGGGTDHDDESIRARPIYRWEGILDDPLRKRKRRRHNFLAKLGVWFGVTPLWRAGTPSMGLALDVRLDNGRYMLLQDEPDELKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6G5</accession>
    <name>A0A2R6S6G5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6G5"/>
    <dbReference type="STRING" id="98765.A0A2R6S6G5"/>
    <dbReference type="OrthoDB" id="3018737at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="16928" checksum="3FE26DB07A6617CE" modified="2018-06-20" version="1">MPLLPLKLSQSPLLSGNLGLSSDFFATLVAQGISPALPSLSFTPSQRVSPPISKQNCPLQGFSLKQDKPLPAVPPTKIPPKQIIALLDLLERMDDDVGKEVQRVRESIGEARHIIMDHREEQNAKDQRVEKRRDLERRETKGVDDEFWLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6T0</accession>
    <name>A0A2R6S6T0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyranose 2-oxidase</fullName>
            <ecNumber evidence="6">1.1.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">FAD-oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glucose 2-oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Pyranose:oxygen 2-oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v183</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose + O2 = 2-dehydro-D-glucose + H2O2</text>
            <dbReference type="Rhea" id="RHEA:10552"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16609"/>
            <dbReference type="EC" id="1.1.3.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.10" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS38000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6T0"/>
    <dbReference type="STRING" id="98765.A0A2R6S6T0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050233">
        <property type="term" value="F:pyranose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012814">
        <property type="entry name" value="P2OX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051473">
        <property type="entry name" value="P2Ox-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02462">
        <property type="entry name" value="pyranose_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784:SF1">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0574">Periplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="15">
        <location>
            <begin position="369"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSS38000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="515" mass="58307" checksum="95A3DDBECE2551CE" modified="2018-06-20" version="1">MSRVRSRFPIRSTISKNFRQDKPFLSLSKNPAQDPFLNLGAEAVTRGVGGMTTHWTCATPRLNPYKELPQLVRDPAANEQLWKKLYDEAEHIIGTSTTQFDESIRHNLVLRNLQKLYEGENRVFRPLPLACHRLPDPDYVEWHATDRILEPLFTDPRLSPLFTLLTNHRCTRVNIDPSIPSPNSHTVRCAEVKCLLPEIEGRDANDSTFYVHANAYVIACGAVGTPQILANSQRTIEPKQRNADPKDRIIETPLTPNLGRYITEQPMTFCQVVLDASLINSVDENPWNLPWWAAKVDAHKERFPEDPIHIPFRDPEPQVTTPFTEDHPWHTQIHRDAFSYGAVAETIDTRLIVDFRFFGYTEPRELNQVIFQDSYDDAYGMPQPTFKFQMSDDDRQRARRMMDDMCSMALKLGGYLPGSEPQFMTPGLALHLAGTVRAGLDEKETVADTYCKVWNFDNLYVADELFPSSKLASTGNGVIPTGFGANPTLTSICYAIRSANQIVENVTAALAAKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE12</accession>
    <name>A0A2R6NE12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear control of ATPase protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE12"/>
    <dbReference type="STRING" id="98765.A0A2R6NE12"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="66497" checksum="8DB3BEB1EAAE3295" modified="2018-06-20" version="1">MSTFVTHLHHDLSSRILPPRTTTPPSTPGPSLQSIEDLKSYFLELQPPLSIDAAKDCVEVIQQLDSRRAFSPALDGEQEALQRSITEKLVVGLYVQCLETFLNEASDAETELEWWGDIERSRWYTSYYLLQKFAALPLRLANLSRTILQTVRSRNIPLRFSLLSPASIRQLFPTRNIFHANKLTVALFPHLQHEPYPVSLLALRHPSSKSSRSLLPHVQTTLEMLTYKTSQLAHSLWTTIVLPVELTRNECRYKRMQLQKIRDDRAAVLGRLMGIKETLISTLQSSEASSLDAFSVHLRTQLEFEEYTGSAPPEEAMLYFFTLANQTLPNHVAQHNLVIHEHGLSRPSRLTRLWPKLVLLPPLALYASRIAYESRASLAQTARDAVETMKMFWQDWLLGPLKDVVRTVRAGSDVGVIVTKESVKADLEVDIDQALSGIDRLLKSQELTFAFVGVAPALAIVYVAAGYLRTVWSGSRGKGRYGGSRKRAGGWLSMRRIERLLIAEESSKDIEPKTTGLLLLSTTHLRRYAERYLPSNSRLHDGFLEDVTYLEDPALGREAKLRILDRMWRSWGEALGWHRAAIENSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF21</accession>
    <name>A0A2R6NF21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional adapter 2-alpha/beta-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF21"/>
    <dbReference type="STRING" id="98765.A0A2R6NF21"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional adapter 2-alpha/beta-like" evidence="2">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Transcriptional adapter 2-alpha/beta-like" evidence="2">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="325" mass="37120" checksum="1551E347DA617807" modified="2018-06-20" version="1">MDLNFDIDPDEFQDRKRRRISTMNTNPPPGPKIAPTSAPGVHEIATFLPGRLEFEHEIDNEAEDLVKDLEFGICLEWGGDQLPEDENDVDVKARARMKEEAKLKDVAPGKRPPNGFANGIVNGLHRGGTPAPAHKAEPASQADGEVEDDEEAVQPPPIESEESLAFKLTLLEMYKQRVDKRHENKAFMFERGILNYKQMQANEKKRPKEEKDISHRLRPFARLQTAEDYESFVADTLWEAILRKRIQELQHYRRMGLTTPADIDKYDMDVIKRNDYERAAGGNPQVLNLDESPKLRKAMTERLRLNKVLHKVSVGWVLLDGSYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFJ8</accession>
    <name>A0A2R6NFJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v13350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001324">
        <property type="protein sequence ID" value="PSR70772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NFJ8"/>
    <dbReference type="OrthoDB" id="3268677at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="197"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="517"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1412"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1420"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR70772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1810" mass="202373" checksum="597897731F208B8E" modified="2018-06-20" version="1" fragment="single">MLSIDLVDNIYFDKNEWVNNNKKWPSEDIPRGLVLFRDAALKIPESHAVQRFYDPRISVPTLFSQTLPKQSSALVHPPAHGCFSTALPNTNAMDLLARTIPPQRLLNDLRNVLGQALLDGAQSVMDPNSRETRYNLWIIQFWTDIASVLCIRARWKGCYNWLSRQPYDPVTQSAYDDARECLNGLSWNARVEVPGCGNIRTSDFATFLSDDRLTDKHIDIMLQLVERRVLLQPKVSATVTIGKLAFINQILKANNPAFYDKPSPPFLTKLEDNLKTKVYRRLYFVVFLAIEAHWIAFEIDFSLQTISYGDSLSLPKPKPIIAKIQWWLQKRFGSVFRDCGNTLEHGVQADAYSCGICAVNVIVHAVFDDSLWTHTHRGVERARWFLAMCRTDGDKTTNTHTSAGGALSSSVREASNIITPIGNAHPLSHRIAISALLNPIDDTLPRMVKHGIPQHEHGCNEPISDTAGINTASNNERLGVDFQGEDYDWMADLPTFEEANTNVDQLEDPSKVVGALEPRFHPFSLKRPAGEELEMSTKDKQPASTREKRKKPKVDSESAGGPVGLGRSTQATTKLNAAVKDGTFVSTPRKVDKFRQKIRELDNRVEFYDDRPKIVRHIPCGGDIAMQVVYNVSHFKRHIQSCTECPPKKAKLSGAGMRRLDTFIVNTASQPLTSTSKSSPPPPTVSPCTGLTAKRYPQIASYLERTSSLEGGSRSLTEIAEEEYDKPYNELTKAEKNAVNTAQKHGKQWENDFDLRSTFSKSCLKTIAAATPEPCERCLALFKQKNFKNTLSKKQVPDENKKYTPKVFRNQGLGEMYSRYIGLRSIVENPDSQHSPFMRFTQAVLDGTFKNDICVGFIQAMMLKIDKVERGVGMQNFKYAPAYDEFMHIINIHSPKAYRFIKEHIPGRTERNIRHNEARQPRFPLGITQRTFDLVQIHINKLEYHGPLGLSCDDTKLHPAFRPYYTNGDDGCYILGGTGEPLQIANPDEFNDTVTSGQLEKATKLRLWCLTIPLPKVAPLIIAALAIGNKANADELRPFTTKIIDGLTKCGINLVSLATDGAAVERSIQTFLEDGAARKLDYKIRHPSLEGKTIDLTIPCFGSDEQGWKPVVMIQDSQHARKTYRNNAYSGSRLLTLGNDVVMYTHARAIAFEDGPLYHRDVEKVDKQDDSAATRLFSADTLQWLADNKRDQNAAVMIYLFVFGELVDAYQSRTASHLERVHAALRAWFFVEMWESFLDSAGYSKSKHFLSYQACSITKRLVQGLIQLVLVFRDEYGSRYPLLPWLLSSEPCEHIFGLCRHIVKDFTLLDFYHMIPKLMVQLREVVLRAHHSNGKERAGGYTHTYTDHREADLGKLRIFPSDEEVNTSAEAAHEEALSLFTLLGVPPTSLSSSSPSNSAWFANNTSAYGVIDSDWRDGDSDSESEFDEDGDCGDEAAHLDNLIYRMEEFNWCTEREEMKLSNLSFAAISLSIEDSVAIHNLPEWSEDEVSQVMKEAADAIAEALAGGNSSASQSSDIDLEAQVNSTCNGNDINLDELISIRRAHQTKQASKGVRVRTVKDDVTANSSQSARQQLIRKLEEIIKQEQERGVGSGLERAARYTEGTKNKTGNSANAADVAKTRASKLLTRRRIVFKKYIPHLEIIRDAGISMLRPLKEVFNTATDGQGACFGLMLADNKVVLAKLLSVYSKAGGKNGNNGWVPSLPIITAATNLAVQTYEHAVGRKFSSIPSNFGQPLIKRHAFLPSNAFLCALSTAPTTVTGNLIEISLDDYQIFKTLLASLPAVRLAVNELGKKRRKKGEAGEDKTEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFW6</accession>
    <name>A0A2R6NFW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001292">
        <property type="protein sequence ID" value="PSR71179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFW6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45047" checksum="788999FD7CD9F415" modified="2018-06-20" version="1">MAGESASEALALPLEVVDLITEHLEDDSLSLRSCALLSLTWLVSARRRLFSTTCFHVDTGDDENEEQPYCEKLSEFLAFLQSTDYVCGFIKELQLFCYNPMVGEATNHQVDLTLLFRVAHKLTSLKTLVLDSVFWSGLPPKSIRAKLICPSIETLVVKDISSDTDDLEQITAIFHLLPNLSCFEAKEWQMEILDVDMDDSEELVLPSRMKLGSLTVFSAPGALLSAVSSTATASTRSLRTLRIYIPYGSYKDVERTGLLLKSVGPNLRYLDIGLSLSPVQDQFIRTVWSDLNLSSCVALRTLVLSVTHPHDTGALSPWLSAESMLSTVPGARLRTLEFELSSFERSSVAEANWIAIETILKRFKQLRVIRFQATKHPGPSAWRYITKRLSSFHAKGMLHMVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFX7</accession>
    <name>A0A2R6NFX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFX7"/>
    <dbReference type="OrthoDB" id="2561686at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="6857" checksum="989597DF5736C68D" modified="2018-06-20" version="1">MSVGSAVSSFTQALAAIGINVLNAIFAVFHAFLALGQETISGVFKLAQAVMQLGSELVQDTVGFVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI06</accession>
    <name>A0A2R6NI06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001224">
        <property type="protein sequence ID" value="PSR72027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI06"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="345"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="627" mass="69007" checksum="3CC20E5CFBF67E1D" modified="2018-06-20" version="1">MPIEDYCKEVDKQLKIDYPTVPKLPPSSSAPWYDADIPWPSGYNASWSPTVVVHLEQLWCVWSTGGNLVYSHTQDNGNWTSPRTVSSDPNVPHTTSCAASLVDLDDTLHLFFVGAAFNITHLQYDDTEDKWGRFDLLSTSEFNARIVPGVVAFQGCIYLTFLRGDNGLWWAYWQPGTDGSGKWSTPKGTGELSWGAAAFVVLGDELHILFTADNDKNPGRLILDIVFNSAAQTWSRSSRQLPGESSASGVACTITPQGGAVAFPANVTKNFEAPPLVCLYRNGVWNANEGFNQKTRDIPIPVVLDNILYCFWLGTDSRINYVKRRLDDRFLVSSWMSDISSSTKLENLCIPGTHDSGTSGAPILIETQTLTVADQLRAGVRFFDIRVGMYCGEVVIMHGSYVIDWTKLGRPLTGILGDIYNFLKVTPTETVIMTMMEQGLNDINALYFSLSDIFKANPQYWYGYQNSTSFPGNLGDARGKIVLVPRTTGLVYNWGFSLANGWGENDPNITIGNVDIQDYYNPSAAGSVGQSINDKWDAVNIGLRRGRTGDGKWHINFASANSTAQAGGHGPEAYAFGNGGQSGINNKLNDYFEAPEKGQAGTFPMDFPEYPNGDLITNIIEANFPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIY2</accession>
    <name>A0A2R6NIY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001196">
        <property type="protein sequence ID" value="PSR72314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIY2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8045" checksum="C22B53C24B98CC40" modified="2018-06-20" version="1">MDCKQQACQDSGKKHSQDSGWVHYTPATYKKAIVKDKIQVLQSFDACSVCAKQAEIFTKIMEGLVKKGLPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIZ4</accession>
    <name>A0A2R6NIZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIZ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NIZ4"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="429" mass="48756" checksum="B3584C169F11BDAC" modified="2018-06-20" version="1">MATDQTKTESVTIAVMGATGAGKSTFINLVSNSKLRVGYGLESCTSEVQVAPPFLLNGKMVTLVDTPGFDDTVKTEAEILRLIADFLAITYEQGRRLNGIIFLHRISDHRMGGVARKNFRLFRKLCGDDTLKNVVIVTNMWADVSQEVGKSRENELISNELFYKSALDKGAHIVRHDNTVASAHQILQEIVGFPPEPLLIQREMADEHKALAQTLVGIDLQTELQRQAAKHREELDGLKEEMAELMLSKDTKHKSELDELVDALSEVRGQLERVEEESRKIREQAESDRVAHEEQMRKLSNAMQTREKELRALEEQAQEQKTRIEEMQVALEAAELKARQEELRRQRLGDDMQASSAVYQEEIARLRKDFERKLEQARADSARVRERHVPPSQAQQQWSKVFAAQRERRGVFGAMSVMLESFWSSGMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ02</accession>
    <name>A0A2R6NJ02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ02"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ02"/>
    <dbReference type="OrthoDB" id="3266894at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="646" mass="68588" checksum="E4D2A10954E5B76C" modified="2018-06-20" version="1">MFSKKPRESILCLFDPLSAPQTPPRETHSPDSSSDKENDGPQPGQLTAFFNRVYTIPKSTKTPKGKLIDFEGSSFADDSVEEDASDEENMQEGSSDARAAGTISESSPSMQRRPLVDIKLERTPPPGVQLPPTIMEEESPQPSPCGDQSTSWSEGPTILPLSATPAPTGTPLADVINSINLSAMSITDSSSEELVSQEVDDDDYLVADSTCPDINICAPESEPSSPYSSPPLNPSATAFLSPIASPPGQCMPQRRQHTTFSPMDPRRFSVDLHSSFSLQMQSSDMSFDLLNDKISILDHGQDSFWSGMGSEDAEDDTMDLARVEMKMKVVAEKYESIKEAEEIKPLPTVNQRTPPKLLLFVDDDANSSTPLRAPVFSLPKASPTGSMGSLISDANSAEITVAPFASLREVVHSSPSPKLPTPSTALPHVPALRIMKKSFKIHDRTGSSSSTGTSDAASRLDEVSSASSSRCTSRAELHSSISLERISTPEAKVEKPRTTIRGLQRPPPGAKVPPAPSRTTGPMRALASSARAISSALSQTSSREATRPSGAPSATAPSRSNLVQRPTANLPPTQTIPASKLHRPAISGTSTLRPPSRPTAMIGSASTTAASGIPGVRSGLPRPASRLPAPSKMIGGKPGSSNLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ56</accession>
    <name>A0A2R6NJ56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ56"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ56"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="267" mass="30462" checksum="AE0344C71F8D279D" modified="2018-06-20" version="1">MASNASNIVFDDIFAINAIDKEGKKFDRVSRLYAHSKNYDMDLTLDYNVELFPLEKDQSFALALASSLARGPPTTNDAGEEEKDLDVWRPDGKGRRGLEEDYEYVMYGKVRAIASPPVGLDLRWRCWLIIANKGVQVRWRDCGDCIRCGKYETDDEHHYAALFHEEVIVPGCRRWLEFVPLKRLSFALGLIRSVTEATISNPHTSEEAKERANERLQNMEESGELDRKEAHDAHVARGRKAALHNPNVSLEAKERSKKALEELEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ98</accession>
    <name>A0A2R6NJ98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001188">
        <property type="protein sequence ID" value="PSR72423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ98"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ98"/>
    <dbReference type="OrthoDB" id="4230923at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="335" mass="37212" checksum="8BCF9F322572ACCE" modified="2018-06-20" version="1">MSSGSKNAPVGSQTQRSTTRSSRLSLNTQPTRINSYVTGLEILRQHTLVPPGAATLEGLSSGLQHLADTVDSQIIKEKIIAFAYYAERVQIEASRDIIANVLLTKLSPIITLLETGSEHIEKGTDRIVDFVEKIESHQNENLEKTQNALSALESASKGLKDAPRYSSPPPDPNNHPQMSYANALRLPPQHATILTREETKSKQVLLEKVNITDQTMGKQLEDEVLLRKANLALEHMGIQANDAPKKCEEIYFASVMVLPRGGVVYEMDSRVSAEWIKKADVKAAFLEKYGRGLDVEMRERKYLVVVDLVPIRLNMEDGNALRRVEDGNGMKERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJL4</accession>
    <name>A0A2R6NJL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Polyprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v11594</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001157">
        <property type="protein sequence ID" value="PSR72536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJL4"/>
    <dbReference type="STRING" id="98765.A0A2R6NJL4"/>
    <dbReference type="OrthoDB" id="2794615at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="600"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="847"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="911"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR72536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1248" mass="137917" checksum="391BCF28EC740E89" modified="2018-06-20" version="1" fragment="single">MSSSEKHSEDSFLCIPKLSVSGNNWVVYKDRLKFAADARGYLDHIDGKVTAPVSPTAPIHADPKNPDPAVEKAHEEAVARYEKEVVVWKKGEALMKQLIANSIPDSLFMKIRGQATAHGMWTALAHDFEKKSRMVSVDLRRRLQDTRCAEKDDLRTHFSKLRDIRESLSAMGHPPSEDDFYAIILGSLPASFDPFISAITATTSVLGTTLSAEDLMLTLSDEYDRRAIKSKGGRKDDSSADAAFSVNEKGKGKSKRNVECFNCHKKGHIKSECWAPGGGKEGQGPKGRVKGKDSAAAAKADDADDAAWMAIVEADTLDLASDAYVSPSMTPLSLDDDGNWFPDDNDAAYCASSDSMPSLDTVSETTELSDIGSDSDWSEISGTSSSEPEWTIEDDPEAAYTLTFDGAFLAKDSALGRELETELYDSGATRHMSPYRHRFIDFEAIAPKPIGAADNRTFKAVGKGSMYIDVPNGETTRRALLKDVLYAPDMGVTLISVSRIAATGCKVNFDRYGCKILDESGTLIGEIPVADGLYRIQHTKSFDYAGRVKDVFTIDELHRLMGHISHDAARDLVRKGLVLGVMIEDSPSSGVCAACEAAKTTRKPIQRYREGERATAVGDEVHSDVWGPAPVETLGGRRYYVSFTDDHSRWTVTHLMRTKDEVFRHYQSFVALMRAHHGVTIKLLHSDRGGEYLSNEFNTYLAEQGMKRRLTVHDTPEYNGVAERLNRTLITKVRAMLFDSGLPKSLWGEALMHAVYLKNRSITRTLGDTTPHEILLQKKPNLSNLHPWGCKVHIHDNKRSKLDPRASVGHWVGFDEQSKAHRIYWPKRRAVTVERSVRFTVSDEPSVVEVPLEGEQVPDEEPRPDSTSTSTNTSDQQETQQISSEDLLEPIPTTPNTLPDVLGPSFEEIPQEGRGKRARKPSDHVRRLLEGEGTAGGRGSAGALPKGLRVMNPVEEIETAGLAEVENAVHSEELAMAAVMGDAEGLQPSLEEARKRPDWPKWLAAINAELESLKTNDTWTVVERPPGVNVVGSKWVLRIKKDASGAIDKYKARLVAQGYTQIHGIDYFETFAPVAKIASLRLLLAIAARNGWAVESFDFNSAYLNSSLDEDEVIYLEQPPQFPIKDPKAYVLHLKKALYGLKQGGRKWYEHLCVALADLGFKRTEADFGVFYARNGPDLTVLAIHVDDCAITGSSKTLISTYKRKLGEKYPLTDLGPVSWLLGIKISRDEEARTLSLSQHAYIDSILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKE6</accession>
    <name>A0A2R6NKE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001132">
        <property type="protein sequence ID" value="PSR72849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKE6"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="421"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="923" mass="104459" checksum="9DAC685D6F6FB037" modified="2018-06-20" version="1">MSLSSLLTVEHTNATVHPYVKQDIACAKSVPYHVWTDAILKLDKRKLKKWVSYIKRREWRNDPVIQEALIQFCGASKETLRYKPYEQIINRILEIAKEQFSGLDPYPIEDIKITRNDPKYIERIPEQGVLGALRKPDLLFVRGVDVDRVLSSKNARFRWSDILTFAELKAESGLIPAMNGWRVQQGLSEIDPNTLKPRAEARKGKSRAKASSSRPGPTRPTRALRGTVAAAPDGGSHALASAPHCSAGAVLHATVQEDCTPTMGSKRARQHDDSESLHIAKKSSIEPGAAKSDMVTLDAIVQAGGYALEVASCTYGTRLFCLGTVMEDDKLSLWYYDAVGIVRTQETISIIHDFETFAAVQVGFACCEPSQWGALPPIIKPPPSAAYPESFPPQSLRGYMFDASIRRTGERVTITLGDPIFSQYSLVGRRTFLYAIKTKSKTLRKPLIAKFSYQVTTRMPEQDFVEIAREAGVGHLPEVHMWEDLWKMSDGVRAAFHEKSDEYEDRVLRALVYTQYFPLKELFSKSCDLISEMVDQMLDCLHDLRYKANILHRDVSCHNVMYEMHGEKVNFILIDFDNATRVDARGAPRPSTKSKHRTGTLPFMAWELIKDMANRELKGYRPRIVHVLRHDFESLFYLSLWCAITIPAMKDQMMKKEIYRLHIREWESGTLKSISSNKKMLCTTMGETDNIDFPLECENLRPWFRRWNALLATAAMQLEQHKLNVFHADDYIDPLFDEETVDGTLSRDSIKRALSGKVRRMRLVDAEPEEPLEPELGMPLHNGERPSTEAEFGPLGEAEENGDPHEIQEPTRLDGRGKDDVPGNDIDDLPRRRIVPRRSDVKGRAKKEPKAKKVASTRKVVEAKKVIENKRPTARRVADIKKLEVMTKTTAPIKPPRRAGPSEHATATRGMTTRSMAKKAMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL96</accession>
    <name>A0A2R6NL96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v11001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001104">
        <property type="protein sequence ID" value="PSR73145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL96"/>
    <dbReference type="STRING" id="98765.A0A2R6NL96"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="108"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR73145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="451" mass="49316" checksum="6BA14950CCAEC0C6" modified="2018-06-20" version="1">MPPRRINDSYMDVDSDSDISILGDEEQSSRVKAKGKGKAVDKSKRDKAKSKAKEQPYAWEASYTRSWDTVQEDEAGSLQGAVEDLIARGRRKRLLAPANAIRRTIIRHLILLMDLSSAMMDRDMRPTRFDLMLQYAREFITEWFDQNPLGQIGVVGMRGGLGERIGEMSGNPQDVLKSISERHKLEPNGEPSLQNAIEMARSSMSHLPTHSSREILVLFGSLTTCDPGNIHDTLEECARDKIRISLVALAAEMKICRELCDKTGGQFGVALNEGHFKDLLFDLIPPPAQRGVARAGGGGISNPAADLMMMGFPTRLPVTSPPSLCVCHSEMKSEGFICPRCSAKVCDVPTDCDICGLMIVSSPHLARSYHHLFPVKAYVAVMSLDDTLNPSLSCHGCALPFKDATAPASGPAADGTSPFGRYRCPECKNDFCADCDVFVHDVVHCCPGCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLV5</accession>
    <name>A0A2R6NLV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001085">
        <property type="protein sequence ID" value="PSR73316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NLV5"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="335" mass="34901" checksum="9CC3EC0C0E80BB5D" modified="2018-06-20" version="1">MSIVVVDDFSNNPDLNYVGDWTHLFSIGGATNNTVSYSQTVGSYIEFVFNGTGIGVAGTVLPMSHNSTPPISTYVVDDSAPTSFTSPDNATQEEFDVTFFLLNSISAGAHKLVINVTRASDDAPFLFDYLGYVPPPSATANSTSSMSSFSSPTLTPTTSATNPSSSHSSTPVGAIVGGVIGGIALLVFSAIILYFLCRRRKGGGRAYFYSSGDPTDMLQQEIKPSLVEGPVVSQFPAAPESTAPPESIDPPTVASGSYFPSTVAGSSNNGSTANLVPPPQRSGKAAQVAPSQSAVFHADSGVRFTPTGEPSSSRDVPPPPPTEIPDEIPPMYTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLW6</accession>
    <name>A0A2R6NLW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLW6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="9115" checksum="6ABE82E4E1FEF1FA" modified="2018-06-20" version="1">MNCLVVTFNDTPEYLRFDSKQPSIPRVFIKSLGLLSYLAPIQIAILDTITRETPTTYKLPSDTGYNNRLRKIHTSKTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLW7</accession>
    <name>A0A2R6NLW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001085">
        <property type="protein sequence ID" value="PSR73311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLW7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="14612" checksum="EC8DD8753A3B496D" modified="2018-06-20" version="1">MGAAPRTWTTMIKLQRASMPFFPSTSSISCPIGKGRSVARRSDTEAVANEAAIKSSQPRDAVAPTLTRMAKGAARAAPAVSSEMWAAESSKPDGCRFSKNFFFIAACHSQPVNVHMGAVNASMKAQPPDQDASARPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMI6</accession>
    <name>A0A2R6NMI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001095">
        <property type="protein sequence ID" value="PSR73244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMI6"/>
    <dbReference type="STRING" id="98765.A0A2R6NMI6"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="151"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="363" mass="38403" checksum="40EA2092C3A76878" modified="2018-06-20" version="1">MSPKGIAILGSGIFAKEAHLPAVAALNSGVAELKAIYSRSEKSATELATAAQQSLNLNEPPSVYHDADPNANLDALLARPDIAAVIIALPITIQPSIVRKALAAGKHVLSEKPVAPDVASGIELINEYNTTYKPKGLIWRIAENFEIEPAYQTAAKIIRGGKVGKVGFFNARVVGYVAKDNKYYNTPWRTIPDHTVAALRVLLPGTMVSLSGYASLNQPHLAPHDTINATIQTTDDSHGLVELTFGSPVPSRSTLANSGITVTGSEGWISIVTASNADGKGVLRITVRTVTKDEKGRDNGETEEVIEEEVRGVKVEVASFLDAINGSDDGFGEPLGALKDVAFIQAALNSNGAPVDLVKLVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMR6</accession>
    <name>A0A2R6NMR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMR6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5923" checksum="B2FE091A01AC97B6" modified="2018-06-20" version="1">MESVIIGIVICPATTYQDFELWETSLNFPVPYQNRSGLYQKEPYSEPAPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMV8</accession>
    <name>A0A2R6NMV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001068">
        <property type="protein sequence ID" value="PSR73711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMV8"/>
    <dbReference type="STRING" id="98765.A0A2R6NMV8"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="75"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="279" mass="31390" checksum="E19925FDEAC9F668" modified="2018-06-20" version="1">MSTQTQTQKPGGQRGRRGNRGRGGNRGGPRGGKPVSASEPKNAPAQPVEEKAPESNGNMVEKTIAVVEEDEDAVCWICAEPVKYYAVSECNHRTCHVCGLRLRALYKKLECTFCKEPQTSVIFTVSPDALWASYSPDSIPYKDAKLAISFETQDIMEESLILLRFNCPESTCDYIANGWSDLKLHTRGTHGKLLCDLCIRFKKIFAHEHALYAPSLLPLHLPSLQRGRITAPKEQIDGGVHPLCEFCRECFFGDDELYAHMRERHEECFVCKRNEVKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMY8</accession>
    <name>A0A2R6NMY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMY8"/>
    <dbReference type="STRING" id="98765.A0A2R6NMY8"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="408" mass="45125" checksum="4C819E3016D73C9C" modified="2018-06-20" version="1">MGVTFEEAIRTDDPNSQHLIGVKDWRTLCRCRFQLESNWSGRGPITSHMLCDRADVHRIKADERVGIVITSYGLGGIMVWDLDSGHALWGLPPTYVRTYAHCEYDSGFLIFDRYGQGKEVWRLASEFDASPLPCDERQQAICDAVARSLQGSSRGHFKPWGLLTTPELGRAFRFVYPTLIVAGYDKAYLYDIPSGQLVQVVENIQAVKDGNLLGEINYVEISPLHALICGTEQLRFFERGSGALVYKIAPTAEAIVSKRLAIDGNPGKATGKLQLVQLTTHEARPQVTIDDTEFVAVHASPDGKTVVALLSDCRLLVIKDIVEVIKGKRTLDESSMEILLQCNHHLPGLNPILSPAAVYLAFEHGHVGVVTVRIYLAIYTIKDSITYGAATRPRVSSYLLSTQLGMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN79</accession>
    <name>A0A2R6NN79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001056">
        <property type="protein sequence ID" value="PSR73847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN79"/>
    <dbReference type="STRING" id="98765.A0A2R6NN79"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="305"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="434" mass="47066" checksum="27697628DEEAAC90" modified="2018-06-20" version="1">MAASPAKELRIAIVGGGVCGLMCAIALAKNGITAQLYEAAAKFGEIGAGIGINPNAVRILRDIGVLNDVLAKTGSNRPNRTGWMQFRSGMQDSELVYDYTTLPGQESIGIHRAAFLDALVQHIDLKSCHFNKRCIRVSESPLSTNGNSELTIHFADSTSAEADVVLGADGIKSAVRPFVTGASTAEHVKFSNTICYRGLVPTEQAKSAGMRLDFSDRPMCFLGQDKHVIAFSIKGGHIINVVAFVSDRTVPMGEAQLPPGQPAVVPVPREQLMKEYEGWGSDVLALLSCIDKPDKWNIHVVYPPLQSYVKGRVALFGDAAHAMLPHLGAGSGQGLEDAHLLAKLLAHPQTSGENIETILQVYDEIRRPRTQSVWEGSMRAGEIYEGYGISGSSREGLRKDLEDLPEFVWIRELNQDMQDATARLQQLGVFTNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NND0</accession>
    <name>A0A2R6NND0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v10369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NND0"/>
    <dbReference type="STRING" id="98765.A0A2R6NND0"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR73799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="174" mass="18437" checksum="C4CA20E2103E8268" modified="2018-06-20" version="1">MPPPKSKGGKMLSLINWRLKVTVNDGRAFVGQMLAFDRHMNLVLAECEEFRRVRPKKKAGETEAGPMQEMKRTLGLVILRGETVVSLTVEGPPPVVDEDKKNALPIGPGRGMPAGRGMGMMPPMGQPALQRPPMPFAPPGMPGPPPGFRPPGFPGGPPGMPFPPPPGFGGPPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP29</accession>
    <name>A0A2R6NP29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP29"/>
    <dbReference type="STRING" id="98765.A0A2R6NP29"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="5">
        <location>
            <begin position="68"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="381" mass="43584" checksum="C5CDE7FBE2AE0392" modified="2018-06-20" version="1">MKVSFSLANSKAKAAKPVGEAPTLKRPVTFASLEDDDPVDAATTSGSSKAPANKQLVAQNMEMSKTTKKRIEQEMKVDATVFEYDEVWDKMQEAKLRQKEVKEVDAKERKPKYINNLLVSAATRRIDYLRAEEKMIQREREMEGDEFADKEAFVTQAYKDQMAELRRAEEEEKKREELEKKNKGIGTGMAHFYKKLLEESEQKHEETVAATTKQKPIVGPQGPIPNLTITKPADFTPKSDVELARVARDQGKDVELNDDNQIVDKRELLSAGLNLSAPNTRRLGLQLSKKDSEEPVQVHRAVGTAASRKEINERRAREITKQMEEERERLLKEREREEQESINRIVSKRNTEEDVMSAKERYLARKRRKLEEADPASEDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPX8</accession>
    <name>A0A2R6NPX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPX8"/>
    <dbReference type="STRING" id="98765.A0A2R6NPX8"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="590"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="856" mass="95556" checksum="D402E2C629119422" modified="2018-06-20" version="1">MPPARLKTVSRSSSPPASPKSDASELPVPSSPVSSSSPVPSSPVSRATSSFPTTSTFSASGSTAPSTPPPVSHDDEEDEDITDEDEKKWAKLEPFLERVTFYAKVLKEQMDKAKVSYSAPPPVATTSARTTRKRPLSQQNEPRSSKRVKVNALVKQREENAVGQVEEKNMHKDDDEEEDEEMHPRFTQPILVSGATLKDYQLEGVAWMAGLYNNGISGILADEMGLGKTIAFHAFLRERTPAPFLVVCPLSVLHNWAQEFKKFAPEIPVCVYHGTREERADLRQTEMVIPEADREKWWLGDRPAAARRQPATKGGRKSKTKAGGAKATRKATVSSNPFPKAKAVSLPPNQKTTFPVVLTTYEMVIKDTVELGMYRFSLPTTNTTNSPRTTKLINTLHTILRPFLLRRLKADVETSLPPKKAYVLYAPLSVRQREVYDAVLNGGLRAMLMKGKGGSGVKVKEDGDEFDDTKDDGEGLKTRSRRKGKNGAGRKRYTHIDGDDDEYFKRLENGELEAEKERERLHTKTNEELGREWQYKAQLKKVNNMKLQNTVMQLRKVCSHPFLFDWPTDPHTLEPILNDELVSASGKMMLLEQLLDELFERNHKVLLFSQFSTMLDIIDDWARELKGWPICRIDGSTSMADRRDEVDRFQNGGDDPDAPRLFLLSTRAGGLGLNLVAADTVIFYDQDWNPQMDLQAQDRAHRIGQTRPVLIFRLVSAHTIETKIMQRATEKRKLEALVIAKGKFRTPTQAANGRYPVKNKIETMTEMAASLLRLEGEHIRIASEGQSVISSKDLDALLDRRPEVFVDRGKGWTSNGVVGEDVQGQEAKGSTSFAVYEAPVDVGGDALAGMMGEPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ82</accession>
    <name>A0A2R6NQ82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000962">
        <property type="protein sequence ID" value="PSR74702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ82"/>
    <dbReference type="OrthoDB" id="2692137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11464" checksum="D01B86FBCBF8D158" modified="2018-06-20" version="1">MVNNVFPPSRPFHMKELPTKVDGLAASNLADRVRYLDALRQIVCRWPNVPPSIQSSPSLLDLSSAPFLEKIEREMAQFYCQTFYEVSGRAAVLPQKFPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQJ2</accession>
    <name>A0A2R6NQJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQJ2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="313" mass="35109" checksum="F05715365ED00B30" modified="2018-06-20" version="1">MIFAGHIAIVCLTQHGLTTTNESNLGSGGLITRKRPIPFSGLVSQQGIHVTASWHQLLKEKAALFEPYSLFSPNRTQTACQDRFNDFTFAMHVPWHEDLANTRLYELACSKAIRTLIFGTMWRQNARDFATIYKATQLPYVTEVCRLPGFEEMWRISAHIKAGIPAGGRQPNFNLGLEDILEEDESARGLNSIDSEDAREEYRESYMLLDSDEMLCDSFPREEIDAMEVDFDAEPSFARDYNIAQPVDGSFRICALLNSSLWMHVVKGRSASRGTNQTRYLAESTSTSPSAILLLGTAPRVHASSTDITRQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQM6</accession>
    <name>A0A2R6NQM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000945">
        <property type="protein sequence ID" value="PSR74894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQM6"/>
    <dbReference type="STRING" id="98765.A0A2R6NQM6"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="8">
        <location>
            <begin position="753"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="937"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="115792" checksum="76E56670284D7191" modified="2018-06-20" version="1">MSRREDQPATASSDSAARTIRTANVTSSNNDADTPSPHDFALAALPGTPISRAGLLQPKSYMSSSSNTSRTRHWAVPHTQEDIRDSTMQLSSIPLRSPLSTYSRERDSFIFPTSPGHTPDDAAGGPSLAASISSVQTAESTIDLTESTVSSSDSTAAPTPRGHAGTFHPSGLSILLARQAEADDSTSPTPTAEHNSTQIAVLSAHTPYPESLDEREENPNRSSERTPLLGDVESARSPSAHNGYAYHVCAHPEPVSKRTTRGTVAEWSDHMRQTASPENLKGLATTVVRSLPAVLLGTLLNVLDGISYGMIVFPAAGVFTGLGGVGVSMFFVTAIVSQLVYSSGGSGFAGANGNMMIEVVPFFHILASDIASMIGEDKPKEVIATTIMSFALSSLLTGLTFFLLGALRLGSLIGFFPRHILVGCIGGVGVFLIITGLTVSTRMNDDEFSLSLSTFKFLCLNVHNLALWLPAFILAVLLRIITHYWHHQLAFPLYFIAIPIIFYIVVAAARLNLQTLREQGWLFDMATSHEPWYRFYTYYDLGATRWSAIWNTLPTQFALLFFNILHPPLNVPALAVSLNHDVDTDKELVAHGYSNLLAGILGTVPNYLVYVNTLLFYRVGGVTRVAGFLLAASTTVVLFVGTGPIAYIPVMVVGALIFVLGIDLVKEALWDTRHRVNRSEYITIASIMICMTVWDFVIGVLFGIVVSCFFFVVQSSQRRSIRALHTGETVMSTVRRPSAHRAYIREVSKQTTVMRLQGFLFFGTITNVEETMRKLVSGPAWETNPIRFFMLDLALVAGVDLSAAEALVRVQRFLSAKQVVLVFCGFSFESPIGRALGSVNLLETEGVELFSTFSDALEWTENAYLKAWFVSQKTETPVVELPGRQDINVPQDDSANTPRKAQLLEAGWRTIARDHSSEFVDADNPEPYLTLVRAFSSFGTVDRDEFQPLVAYLERMTLPEGFVLWRQDDAPNGLYIVESGVLRAVYHFSEHTQNTEESMVAGTVAGELSALSETPRNATCTVERQAVVWKLSTESLRRMEVEHAQLAKSFTKLVLKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR14</accession>
    <name>A0A2R6NR14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR14"/>
    <dbReference type="STRING" id="98765.A0A2R6NR14"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="218" mass="24227" checksum="A0303EFC269BBBAB" modified="2018-06-20" version="1">MAGFMSYFGGRRDPKQSSREAIVTLRQQLQMIEKKGDYLQKKIDEEMKTAKANAVTNKTAATAALKRKKATEQELERLQGTRFQLEMQVNTLESASFNAETMNAMKKAAGALKDIHGKLNIENVDSTMAEISEQTQLANEVSEAISTSTYTGMEIDEDELKQELADLEQDELNERLAGAEHVPAHRLPGPSRVEDSRLHSAEADEEAQLKELQAALAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR24</accession>
    <name>A0A2R6NR24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000937">
        <property type="protein sequence ID" value="PSR75063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR24"/>
    <dbReference type="STRING" id="98765.A0A2R6NR24"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="657"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="838" mass="94928" checksum="3F86C98D56A44F86" modified="2018-06-20" version="1">MDVGDRKTATLVNNGVKHPPVLTTGLLTPKVIQQFQIACQHHFNYRKVTDSDKVMTIAPLLQSLTVQLWYFSNQATLTTGTFVEFMSALRKRFLKKNWADNIRVKLLHSTQAKDDSFDAWVESLELSNALLMNTTAFFSDKHLCEHIESHAFEDLRNLAKTSEVIALADFQKFKEALSEADCKQRMDCAKRKREIESVLASHSRTVPFIPRSTPSSTGTPLYGGLSVGDNANTRCAGMLPKLTEGERKLLEQSKGCLKCRKVNTGQFAKACPNGFPNPANYRNLVTGKATVAAIANQPGAIENELVDISHVAVINSTSSTPSCVLTSDDEDWESDKYVQPPLTLPHIVWNARLHSPSSFENPIKMLINTGCTTVLICEDIVIQHNLYRHPLHKPFQYCMAFGAEVRSSSEKYRLCVSTPNFSWSSILVDAIIVPELCSPVLFGLPFYHINKLLIDPAHQMLVCPNGRDLLCPSPPIVHDVRNERQCRHDQRQEQHNQKILEQEKVTLESIMRETQHKDVIRELNLRFSINKHKTTPEPPPESVVTAIQRHIGEIALLDILAHKNKQMRSRFADCFPDDIPHVNKLPTDVYHRFRLKDPNAVISQKQYKCPKKYRKAWKTLLQQHLTVGCIRPSSSPHALPAFLIPKTNPVVLPCWVNNYRKLNSNTIPDVHPLPSIAEILSDCGKGQFFAKIDMTNSFFQTLVHPDDIPLTAVTAPFGFHEWTVMPQGCHNAPATHQRRMFNALREHIGSICHVYLDNIVIWSQTLEEHQKNVATILECLRKHKLYCLPRKTDLFCVSINFLGHYISANGIEADNKKVEKILDWPVPRSASDVRSFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR41</accession>
    <name>A0A2R6NR41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000929">
        <property type="protein sequence ID" value="PSR75103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR41"/>
    <dbReference type="STRING" id="98765.A0A2R6NR41"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="80532" checksum="E1CB37F941366CD1" modified="2018-06-20" version="1">MNGTASTASVAASKLGDLLATLALNNQWYDIELTAQSLANDLRVTDVDQQTVLGKTLLPSTLTNLLKGAIDGAPIPAAPQKQAVVELLRAGANLCRDHDDNRSNLLEAGFPQQVVALLEGYAESVVPNESEPLPLSTPDLKIVKTAIGVLLNTSVGYEPVKTRLISLEAAFTILKLSIAIYPPGCWLRPQKPVINGEPVGVMGVDTEVWSLRTGLSQWAWRTISEFGEDEDGNSRCLFTPDALPYLVRSLHAFIPPYPTLPISLSPELIQTLIQVDFDTLEECAGLIESLSMDVEDVRLSLARGLAFPAEHGGVACLSDMLTFVDKGNYPPYWAENPDERAAREKGFDRCKAAVIKSTVELAGEEKNIDVLWDDSDPEKPGGEFVFKMVQWIRQHKSLQETNRDDLIICATLSLGNLVRRDAHAAAIVNPPVALMPDLATLLEPETDIKVKHGVIGLLKHLSQTQSNRTILGNAGIMQKLATCQIWSEKADVVEIVQVAAIGVAKHMCNSNAENAMALVLPGPDQPPSSTALAQILSLVRRSDSVAVKSEGTRVLVNAIKSLWSSDASSNDPAWPERRKEATAQLVTPVCAAALAQLIGRSRKYPILINEGVVALSLLSTHTSGGDPIGTGLVVLDALLNPLPTETPPHGGPLSQPISAGPSTDSPAIGMPRRALDMLVSSLRNADGRTPVEVRGNICALLGRLGRQGVVPESRVHDVGAMKLSTKEWVEEAAREEGPLGGAAKKTLEAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR49</accession>
    <name>A0A2R6NR49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000925">
        <property type="protein sequence ID" value="PSR75119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR49"/>
    <dbReference type="STRING" id="98765.A0A2R6NR49"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="294" mass="32122" checksum="CDF3B2C0EA3CA32A" modified="2018-06-20" version="1">MEDRLRLSPSLCRSPPVAPYPLLSLPFDFSMNIIETLFGRTVTPAERLRQHQRALAKAQRELDRERTKLEQQEKKLVGDIKRSAKAGQLVRITVPKSPSENACKVMAKDLVRTRRYVQKFYQMRTQLQAVGLRIQTLRSNQQMAEAMRGATRAMGAMNRGLNLPQIQRIMREFEKESATMDMKEEMMSDAVDDVMDEGLEDEEEEGDKILRQVLDEIGVDLSQQLTDAPTGLAMSSSLTEPKQAVVLGDGGPSHFGGDSSGGGGGGSGGGGGGGGGGMSDEDALQARLDALRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS22</accession>
    <name>A0A2R6NS22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v8958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS22"/>
    <dbReference type="STRING" id="98765.A0A2R6NS22"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF429">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR75667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="337" mass="37813" checksum="0897363867780AB0" modified="2018-06-20" version="1">MRTIGTTSSNPIRLRKGFHTRRDSADSLHWEVTRLHLNPSSRVSGWSTNSLLGEGTYGQVYLVQHTATGTEYAMKVVPIDRPMPAVICKGLINELLALEKMSNSRHAVPFVLKPSSDSPARRWAWQSTQGYLHILTEYCPGGDLRDYKGQLSAATLRLVLAELVIAIDNLHKMGIVHHDIKPDNVLVDMKGHCLLADYGGAKFLSDDGTVNLNIEEDVMSTLPYAAPEILSEDCDPDGMKYYDEAVDWWALGATILTLVTGEEYFYGSTIDNLCDNIPRLLEQVRSTLENYHCCPELIDFVESLLSSQMKTVVKAWPHGRINSTRWFLEVIKPTYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS96</accession>
    <name>A0A2R6NS96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000880">
        <property type="protein sequence ID" value="PSR75737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS96"/>
    <dbReference type="STRING" id="98765.A0A2R6NS96"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="351" mass="37670" checksum="5124871B0586304F" modified="2018-06-20" version="1">MSVITTPITELFKIKYPIILAGMDRAAGPELAAEVTNAGGLGVIGGYGFTPKALRIQIAEIKERLHDKNAPFGVDLLIPQVGGNARKTNYDYTKGQLPELIDVIIEQKVALFVCAVGVPPKEIVEKLHKAGIPIMNMIGHPKHVAKALASGVDLICAQAGEAGGHTGDIPATLLIPACVDAVRGHTSPLTGKPIYIVGAGAVYDGRGLAANLMWGAQAVWVGTRFVASVESNAPKAHKEMLLNAGYDDAVTTLIYTGRPVRIRRTPYVDDWNNNRQAEIKDLTSRGIIPNEAELEKHPEKSLESRTFPIGRISALIHEILPAKVIVENMVEDAAKIIEANANRVRSAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSC3</accession>
    <name>A0A2R6NSC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSC3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5298" checksum="7F93F058A71466CB" modified="2018-06-20" version="1">MRYFRRVGVSPSCPPIACKTSDKEDDGMEGPEAITWDLAVACLALAVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSN0</accession>
    <name>A0A2R6NSN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Charged multivesicular body protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSN0"/>
    <dbReference type="STRING" id="98765.A0A2R6NSN0"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR75897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26300" checksum="F01A744F4895639B" modified="2018-06-20" version="1">MIFPILKLQRDKIRQYQKKVRRDGCQPPNPVIIAHGLSQIQGVLDREFEIAKEQLAAGQKDRALFALRKRKYQESLLAKTDVQLENLEKLVCISKVPVFPMLTVQHQVSTIEFSLVEVSVLHGLQQGNEVLKEIHKEMNVETVEKLLDETAEAQAYQREIDNMLANSLAVEDEEAVQAELAQLQREAMGEAEPERPLELPSVPSTGLVTRQAIGNWRKKRPQQSEFLSQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSQ8</accession>
    <name>A0A2R6NSQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000871">
        <property type="protein sequence ID" value="PSR75958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSQ8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11332" checksum="2766688AA582FBBB" modified="2018-06-20" version="1">MNAAPIPIPRARTGHGNHVPLYNNFIGTWGAYYRPNVPRSNAARNSKTRDKVKALQVAVFVAMPSEDRERQQHDAAAEMEHDALAIGIAEVPWLKGDLVSDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT20</accession>
    <name>A0A2R6NT20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000880">
        <property type="protein sequence ID" value="PSR75736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT20"/>
    <dbReference type="STRING" id="98765.A0A2R6NT20"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="208" mass="23188" checksum="4F056CE716DCBA6F" modified="2018-06-20" version="1">MPYVANVDQELLPVHLRQHFTASVRKLHLDFSLRSTNPASTPTEECERLRAENASLKSCCQVWRKRASIHAAATLGFVGLARLARDHAVKMKKEKNDLEEKYHALKRKYGSPENLSYCLPTPPESFDVPRIAKPTPRAISRSNFRPVSPCSSEDSYCSDCPDCQPPVKRQRTSESPISHVKQSPSTPEIALPASPSLTTSLSEMTVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTL6</accession>
    <name>A0A2R6NTL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spastin/Vps4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8464</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000846">
        <property type="protein sequence ID" value="PSR76429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTL6"/>
    <dbReference type="STRING" id="98765.A0A2R6NTL6"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spastin/Vps4 C-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13771" checksum="2DE6D7BF356A60BF" modified="2018-06-20" version="1">MQPVRKVLSATHFKQVDEDGKMKWTPCSPGDIEAEEKTWTDIDSDELLEPPLKIADFLKSLDSVRPTVSADDIKRHDQWTLESGKTKLSVYKCTDLSYRLALHRQRGRMTCKLTVFCNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTR2</accession>
    <name>A0A2R6NTR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v8415</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTR2"/>
    <dbReference type="STRING" id="98765.A0A2R6NTR2"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase Y-family little finger" evidence="13">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="202"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR76512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="355" mass="39546" checksum="7319B4E99E915DEE" modified="2018-06-20" version="1">MDKQFGLHFLLQTYLGIASNVVQPGQREERKSIGAERTFSAIGDKNKILAKLEEVAAELEEDMERTGWTGKTVTLKYKLDTYEVFTRAKSFDRWISTKKEDLFATGKELLMPELPLKIRLIGLRVTKLKDLRLDTDKEPGSIKRFFESAKPPASPSKKRNSEPKIDDEDSEVEPNLTQDGYEDAMPGYHEEIELDIEELRPEDNLPQHGDDSVMAEKLRPPASSSGAKSHKPASSSSTSNSSRPFEPIRHVNSDSSSSKPASKSTSTTKPSSKRKRSLTPNSGRNLQTEICPICEKNWETDNRGLNEHIDFCLSKGAIREAQAMASNQTALSALQPDSVSRGGPNQTGRKAARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTU3</accession>
    <name>A0A2R6NTU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000843">
        <property type="protein sequence ID" value="PSR76460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTU3"/>
    <dbReference type="STRING" id="98765.A0A2R6NTU3"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="307" mass="34869" checksum="7EB9CC9D1751ADC0" modified="2018-06-20" version="1">MLPPYPINRSPRSVKRDVRHTAYIPRYSTISFAMPASSPRDRRDGKENRAFNPVRLLCPSCHRVLRNLSGLTKHTHTFHARPHGHTLPTHGAAINNEPNITVQPLDDSPQHQVLKDGRLYHLVHPKMNGRPCDSQGRFLNDPTSQPSCRTESATNDWTPFASRLQFETADFLFQRARMSQGNIDRLLELWAASLIPYGALPPFAGVPHMLETIDSIPFGDAPWTSFKVRYTGDLPPNPPPWMTAEYEVSHRDPLVCVRNMLANPDFADEFDVAPYREYDPSLKRQYTNLMSGNWAWKQAVGSYSNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUF5</accession>
    <name>A0A2R6NUF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v8209</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUF5"/>
    <dbReference type="STRING" id="98765.A0A2R6NUF5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR76828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31323" checksum="2BC14489B024EB53" modified="2018-06-20" version="1">MYTLMGSVTSAIAAALLFGLFWKLTKELGKTPSRLPPGPRPLSIIGNVHQLPVSNQHEIFFEWGQKYGDLIYARLFQTPVVITNSIQVARDLMERRGSNFSDRPNFVLFNELMGWGAVLTHLPYGEKFRKQRKWFQAAFQSKTALHAFQALQRRETYVLLTGLTDSSNAFRSHLKRYAAAIIVEIAYGHTVSSLEDEYIEIADRATTETVTAGTPGASILGLLVDFFPILKHYPIWLPGSGFKIRTNEVRRLVNRLFDAPYKMVTERMVYRESLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV43</accession>
    <name>A0A2R6NV43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000831">
        <property type="protein sequence ID" value="PSR76873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV43"/>
    <dbReference type="OrthoDB" id="1931687at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="339" mass="36719" checksum="8068B7ED6CCCEE01" modified="2018-06-20" version="1">MSSPSIKADMITKFTGSNYAKWNISFKSACRIAQCWGVVAGTTIKPATGAAEIAAWETKNNQGLGFLGVSLAPHLALRFLKDDAKTSAEVYALVKADYEELNALGAFNIFEKFYAGPKLQANKPLCAQIDKLLALKQDAVNAGVTISDQYEAFALLRVAPPEYSNAITSVLQSKDITTITGKQIIEALLQEESLRTTSAVAGRVSNTTNKPKKCGLCGKKGHLQENCWDDPKNVHKRKGKGKGKPGNNNNSANNSATVSSIEIVDVPNVTVPAPEESICISLYSLHDKKLSWMLDSGCSNYITNDFKDFIPRTYVSYPLPGVAQLAGTCHTMESEIGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV78</accession>
    <name>A0A2R6NV78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV78"/>
    <dbReference type="STRING" id="98765.A0A2R6NV78"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="10026" checksum="42674A490C58C22C" modified="2018-06-20" version="1">MTSRLPKLIAFDLEYDVFTTKKEYPDLVLPPTSSKITHFKKLHEKTGIPYSEMNGVDDRTFEGGLNEWRNRHPVEVIEDAGGSATQSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVY6</accession>
    <name>A0A2R6NVY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000767">
        <property type="protein sequence ID" value="PSR77939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVY6"/>
    <dbReference type="STRING" id="98765.A0A2R6NVY6"/>
    <dbReference type="OrthoDB" id="5389493at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR77939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="35205" checksum="7499F58D39E0B66E" modified="2018-06-20" version="1">MSTKINYAAYDGIHRSELPAAIIFTVIYVPPLLISILLAFRKKTSVYRALVLFSLTRLVSFALRSALAGNTSAAENENVLIAEQVIYSVGFAGLIYSAYTLIIDRDEMVNPGGNGGRTGIFLLLGRILKYPNVMRLVITVAIVLGIYGGVKASDTNPNQQSTGSALREAALYIFLAVVCILNILTLLLAADERRVGVWGWNHTAFGQRYGILVLLVIAVMCLIREAYLVSTAKNLAKVGVSLSLNVFRLLIQPYLFVQQNRAPLFYPLAALPEFIAVMMFMVPGLVPSKIELLERANGSKSGRVTDSGIPMTQEPQYASNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW60</accession>
    <name>A0A2R6NW60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000758">
        <property type="protein sequence ID" value="PSR78104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW60"/>
    <dbReference type="STRING" id="98765.A0A2R6NW60"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="2"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR78104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="305" mass="34129" checksum="8A16D448A645545E" modified="2018-06-20" version="1">MALVNPGDAVLVESPVYAGVIPMFTALHCELVEVETDSNGICSQSLRSVLENWPLIKPKPKVLYTVPYGCNPTGMTAALERRRKVLQLAHEYNFLILEDDPYYYLYYGDAPRVPSYFALELEQPEVGRVLRFDSLSKILSSGIRIGFLCGPDPLMQVIDMHTAVASLQTPSLTQTITFALLNSWGYDGFKTHTETVSQFYREKRDVFEEAMKCHLGGLAEWTTPEAGMFFWFKLLLDGEGSEEGDSAYIIQEKAVEKGVLALPGTVFLPNGRKTAYVRASFSLLTPEEVDLAVRRLRDVILEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXM8</accession>
    <name>A0A2R6NXM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="13">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v7043</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="13"/>
    <dbReference type="EMBL" id="MLYV02000696">
        <property type="protein sequence ID" value="PSR79398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXM8"/>
    <dbReference type="STRING" id="98765.A0A2R6NXM8"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="14">
        <location>
            <begin position="296"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR79398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="484" mass="53783" checksum="73376E95416C1175" modified="2018-06-20" version="1">MFAQGATPGKVDTWCYHEDDEDFTKDATALDIWVLDQLRTLFHNASTDASLSAHLHQEKTVFFLHLLGLDTTGHSYRPHSKEYMANIQVVDSIVRQTEAMFSEFYKDESTSFVFTADHGMSKIGNHGDGDPDNTRTPLIAWGAGVRGPLPDTTPSSHDEYSAPWGLSHLLRQDVDQADIAALMSALIGVDWPVNSVGVLPDVDPTRPGYLRSEGKGQARAALINAQVLLEHYRVKHVLKKTHSLFYKPFPYFSDDSEWEHTPGIKGLANITQLLATERYNDARKASAELIKQALAGLRYLETYDRSLIRGIVISAYLGWIAFSAAHILPEEFVQPLQSTFALNAISAVILVAFWASFALQKSPATFYAYMAFPVYFWRHAIKATGGSVVALTKNPAVDRVALTKVIVRGCLVVAALQSMVVAYTHRSIWSIGFVIMGLVWPLLTWPTEMTKEDPYLFPSWAGLCTITAIFPLLPVDKAESVMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXU2</accession>
    <name>A0A2R6NXU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000695">
        <property type="protein sequence ID" value="PSR79450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXU2"/>
    <dbReference type="STRING" id="98765.A0A2R6NXU2"/>
    <dbReference type="OrthoDB" id="3362250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="11779" checksum="BA9025D61E57CF37" modified="2018-06-20" version="1">MPAVSASLPQAQTTPPSEAAPVPTPIPLLTYHDRTPVWTVGSTYGLIEIDKLRERELGVQTSFYVAVALTYLEFLTEREVSAKIAFCVLIGFMTELVTTQSYIAATAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXY1</accession>
    <name>A0A2R6NXY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXY1"/>
    <dbReference type="STRING" id="98765.A0A2R6NXY1"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="310"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="497" mass="53914" checksum="7AA822319E08A442" modified="2018-06-20" version="1">MNFLDTYDVSGTSTPREGPEPTLNEEVTQVVGQLSRFWGGFRKQSQTVFETARKDLGQVVSQAQKELTKLTAETPAETSAAGTTPNETDDIPATTDESTDVEAGPSGESSTTPSEEGSTITPGSSHNRGTSVSATAQNLFTRLQTSLPANLASTVQAQIPESFRQGTGSIDLTQLRTTLASEFQRVQGITRAQAEEYVHKSEELLREAGEFLKDAVKVVPPTEEGYTPGVMWDGTDVWLLPEVGSSGTADVKGKERQERSGEGIGAVATRAAALLKQLRHDPEVIRRDPESEANTGDLWKEWVSAHVDAKEDGINNEEWKDAIEKALADLADGSALQNTVDVLVPEAMTSETFWTRYFFRVYQVEQEEERRKVILQGTTESEEDFEWESDDEETTASKIPPSSVAEASEPSAHIVADSPSHSVEASTSRETLTASKASVVSTPATGSPRHSSEDSYDVVSSQVSNNGESKSESEPGQETRRKAKTGNDEDGDDSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYE4</accession>
    <name>A0A2R6NYE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000661">
        <property type="protein sequence ID" value="PSR80237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYE4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="211" mass="23993" checksum="47E543235A4E2649" modified="2018-06-20" version="1">MAGHHETSGGGYRQYREPGMVTEGSTGADIVLREVTFEQSASLQMAQEATSAHEAERLVRVEQDPQYRIRAAQQPLMDAFARTTMMPDGKSSSGDVPTFNLMAPSELPDDFAERLANPRVNPRVKAKFHAITQSPEEFDALIVEIDELVNNLCEKGSEKSMADRERIHLQWAQFVLHLENQPPLDHIWKYEIAKKHVLQFLPFLVHFPWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYP5</accession>
    <name>A0A2R6NYP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000649">
        <property type="protein sequence ID" value="PSR80549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYP5"/>
    <dbReference type="OrthoDB" id="2751365at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="529" mass="59624" checksum="249BD6553F1AA01D" modified="2018-06-20" version="1" fragment="single">MYRLLSEPKLMEKIVEELRTPLKGPTFREDYHAFYALIHTCKALSDVSLNALWRKMDSLLPLMELIPTVAWLGDQKRDSVLPNLKESQSMEADWSRFHLYAARIQALSIKSIPTIAALRGYELVVPTLHSLPGVSISDILQEHIPSSSNLLPNLRTLNWHIQDPTKTPYLPLLFSTGLAACHVTAGDDIDEILNILADKCADSDRYSDDNGSILINEPNSFDPHLQNYHVMAHLLPRLACLPALEDLRWAPGRGHLSLEDFRWAPSSGQRAEYMERGFDTCFPNLHSIWLMVALRDLDHVATFLSSIQTTALRRFTLIAPGESHPDASPMLERLTEALSGHRGLQAFSITLTIETPVVLQNSPHIDSLVRLTELEAVSFDGNFSIADECLHRLSYAWPRLQELTIISLSPNVAPQASPTLGVLECFAAHNPRLTNLHIMLDARRVPTRHHDNLPERLDPIYIHFDWSPISVGSSIQFAEYISNIYPCAELRINSYRPPNYGYPRTKVWQEVDKMIPITSSVNFGGVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYR1</accession>
    <name>A0A2R6NYR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000681">
        <property type="protein sequence ID" value="PSR79828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYR1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5589" checksum="4F941705875B6177" modified="2018-06-20" version="1">MIMHKKLTDTLIIVQDTPELPYDRIKAGRGLTEKSSQKGKVIKEQAALPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ11</accession>
    <name>A0A2R6NZ11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000633">
        <property type="protein sequence ID" value="PSR80922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ11"/>
    <dbReference type="OrthoDB" id="3265128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR80922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="371" mass="40413" checksum="853C4DC6A402B70A" modified="2018-06-20" version="1">MSAHDTSAAIPSKADDAIRQGKFCSYTWLTHRARADAAMSNDELTFNADGVLVVKMADRSGDRSIVQSDWFNAADEAEKATRRHHPADRGDALALHHANVQNMNSTHGWTIAKEYDILQRELWAGDPRHDIGQLHLGLLTQITTSFLMRSDRHSASSPQSSLKRGASTPLMAQQKRPRTAPLGPMPSYCFRCGHAGHLPSSCTAQSTAAGKPTATVSGNPRNPHTMLGPNGRPFCFNWARYGNCPYAPEQSMVLEPALPPPDPRQVVTPLDPDAVEKKLSELGILAQWQHVVDGLRLGFDVGASEPIRQSLYFKNHTSSELAPKFIDNYIRQEQAAGRYSQAFDPTDLEGIIGSDVPGFGSGQKAGQAGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZG9</accession>
    <name>A0A2R6NZG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000623">
        <property type="protein sequence ID" value="PSR81265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZG9"/>
    <dbReference type="OrthoDB" id="3023191at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015315730" evidence="2">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="300" mass="32575" checksum="C0E913553D888393" modified="2018-06-20" version="1">MQPLHFLTAFVFLSQSCAGVVYPEARAEYSLVPVAIEDTKNVALIDTHSSRETSLEVRSGDSSLASVGTTWNFNGGKFLIGLTLFTNSVVFLGVCAASGAISCAIAAAYAVFTLFFAKWVFGGRSLSELDDLGADSEMYLTLPPTPEKSHIQRLATELEPGTWHTIGTMRVGMFNHTIHYHNNGAGIHKLRAWQKNFVVNGTAKRVEDNNDGTVVDYLWQSTNEQSYNDFHSSSDSNSYFAANAMGYMIENQSAVGMCADFGDADGEMDGAALTVGWNGQPFEWEDGEEEAILTGNCNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZK9</accession>
    <name>A0A2R6NZK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v6421</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZK9"/>
    <dbReference type="STRING" id="98765.A0A2R6NZK9"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="322"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="566"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="123"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR81342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="660" mass="73519" checksum="9FE00A43F59A66D0" modified="2018-06-20" version="1">MKALYPTSNEIPKLSEAALALKIARHSPCSICSVHICPGLRPPPIVQLVLDSVEDYDGSESYLSSCSCGHDLADHGADQDLIGSEELARRGRVAVRIDELLQDEDRLLDFDYIDDDIDSLRKQMTLPGSPRSPQSDSFGSLVPSSPDKQPSSPASSFLSDTFDGDGEPPSKRRRVSFSSLSNSSSSSSGEEEDRPLAVKQTERTDHNINTGPKRNGKGKKGGGPRARQRTGGKSMSSMKSKAQTAPTSKLPPNQEQRAEMARPPSKGVNGHEFKMKVEDKMDESQLTRLATGVTVDAGGQASATPGSKPEKMAHIELRKGIINIVAVQNDSDPRSLVILTGLKTLFQKQLPKMPREYIARLVYDSNSKCLAIIKRGFKVVGGICYRPFPHRGFAEIVFFATASVDQVKGYGAMLMDHFKAHIRRTYPDMMHFLTYADNYAVGYFRKQGFSKEITLDRSVWAGYIKDYEGGTIMQCTVLRKVDYTHTRDIISQQRDAILEKIRERSRSHIVYPGLDMWTDGGGPIDPKDIPGLRESGWTPSMAAVTIRTIGKSAEQSAMERLLSDLQTHPLAWAFLQPVNGEEVQDYYEVIKQPMDFATMEHKLDTHQYSNLDQFTIDAQLVFDNCRLYNAEGSLYHKNATKLERFLREQVASLRLKKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P166</accession>
    <name>A0A2R6P166_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v5867</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P166"/>
    <dbReference type="STRING" id="98765.A0A2R6P166"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR83063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="184" mass="20704" checksum="133DD519ED5DC4E3" modified="2018-06-20" version="1">MSGICRARLAEERKQWRKDHPFGFYAKPTKASDGSMNLLEWEVGIPGKATTAWEGGVYKLMMTFPEDYPSKPPKCKFNPPLFHPNVYPSGTVCLSILDEEKSWKPAITIKQVLLGIQELLNDPNVNDPAQSDAYTMFKSVETFASPCVGFDSKLVKTYPSEAACRVYLVSWFVFCSISLTQFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1F7</accession>
    <name>A0A2R6P1F7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Laminin IV type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000562">
        <property type="protein sequence ID" value="PSR83332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1F7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1F7"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Laminin IV type B" evidence="10">
        <location>
            <begin position="230"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR83332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="358" mass="40389" checksum="A5C2D4E4962B2124" modified="2018-06-20" version="1">MAPALTVTETATENVTNALGSVSLKAEKGPSYPRYLPHFDASEKFPPTPVREFSDPGLRADPTKPNLLGPGVQVKQISPYIGSEVRGVQISQLSKEGLDELALFAAERKVLAFRDQDFKDLSPERQIEIASHFGPIQRHPTSGNVEGFPEFHVVYRDADHQRFREYRGADNRAIRTSWHSDVSYELQPPGTTFFWILDIPENKAGDTLFLSQVEAYKRLSPEFQKRLEGLRAVHSAVYQAEYSRKSGGPVRREPVESEHPVVRQHPVTGEKALYVNPGFTRRIVGFKEEESEYLLKFLYDHISKGADYQIRATYEPGTLVIWDNRVTVHSGTGDFPQEQRRHAVRLTPQAEVPIPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5E2</accession>
    <name>A0A2R6P5E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000528">
        <property type="protein sequence ID" value="PSR85643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5E2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11067" checksum="DDE210FDF6C8CD52" modified="2018-06-20" version="1">MSAKHRRLVPTYFWYLKYELQASPRIDCCSALKIIHLIPGEASCIPPCSAEGRRAIFLTLAAASITMQPIKALVPLNSHAANFSGTDLSYRYPLGISEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8T0</accession>
    <name>A0A2R6P8T0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8T0"/>
    <dbReference type="STRING" id="98765.A0A2R6P8T0"/>
    <dbReference type="OrthoDB" id="2794653at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23428">
        <property type="entry name" value="beta-trefoil_Ricin_SPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031755">
        <property type="entry name" value="Inhibitor_I66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16850">
        <property type="entry name" value="Inhibitor_I66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16560" checksum="846996D5C002A697" modified="2018-06-20" version="1">MSLPSGNYIITSKVPDGQSLSIGRNLAEDKSLLPKKVISLPPGVEAPVWAVQLLDNGKYILRIGGAATAEFEDKVFAVLLDVPIPTEWTITHVPQHGPNIYIIEKGDLSTGWVVPESEEPYTQIAVRPLIATRSLPPQYLPSEQFHIIPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8W1</accession>
    <name>A0A2R6P8W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8W1"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="292" mass="32999" checksum="20D9DD9590072B92" modified="2018-06-20" version="1">MSANYKRPHVLKKKKGGGTAYDEDNLFSSQEDDLFGSSSTLQADKQPETASTTVQSTTATTAVTKKSKLFPAERNALFNGTYGFVAQRIGLRPVLKKFPEQVRHTALHHMIQLATTKEQIEQIVALLPKWRESRFRISETTVNVFVLFSDHPKYGMDLNPAAGRQLLHDLHVEHPLSESITLSALYSIYALPSISGDLISCALLTSACYKTATKESLVVARALTQSLQALLDKEDPKAYAYPVNHYERSQNKEKAWLTWTLTKIEKALEKHKQPYDWLRQWRERSGHVQVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC14</accession>
    <name>A0A2R6PC14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000504">
        <property type="protein sequence ID" value="PSR88664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC14"/>
    <dbReference type="OrthoDB" id="2803003at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="575" mass="63021" checksum="717E5A9B1CA441D9" modified="2018-06-20" version="1">MSLDEKLKLLEEVTAALNKEQSTNGRYIPSSNRALGSALPSGKSKAMRYSSVPPSTPEGGSDHDIEMADGHEDPIEVMPTEEEDNIPRAAGLKRCGAMAMVVQVDDIDSDEPEELEPEPEPKPAATSSKENRRKRTQDGSEDEEMEGGNAPSATSTKTPPAAKKAKLNVPQGLIEDWATKVAAAPQSPSIRSVSMMSDARSSTPSVVSMPSVVTSSTIASSAASHAVKKAQRRTSQGVLNIQKMSVSVTEGNVSTTAPKSESDTKAEKGRKVKQTLLPLPPDVDNALEMWQQKFVPTYLSFIGSLKNPWDGNSTKQEINELQRIWTVVFPTSNEVVTDGCIIHKVAAQRGYEYRNNMTKAAAIAILKEWETAGITTEDDRITYIQANLEPDFKCMMSDPENLRGMFESSVILQTFAIHLSSTAGSLIRYGNPVGGLALAAAAVERGFVLWKTGHILSKNELAARIKICTTEDERKRAKKSNARLIYFSQATWGRTTRQYMRSTKNLTKKMWKAIIFKAQVYKRAAKNCEDSESDGFESDQDVRALLVVANPDDDDDDDDDDDYNGGDDNEEELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG51</accession>
    <name>A0A2R6PG51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v4893</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG51"/>
    <dbReference type="STRING" id="98765.A0A2R6PG51"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="548"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR90600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="584" mass="65713" checksum="52777721B2F1CC20" modified="2018-06-20" version="1">MEPFEEENPFDNDTERVHSETSSSSQVNLSEPASPPSDPSRVLTSPPTSPSTSRPTFPSSGSHRLPQVYKNDYCCNRDQWLHSGEDVEILITDAQKTSVNSTSPYIAYIIQSGGAQAYHRYSEFESLRSNLVKLYPTLIIPPIPSKQTIGDYAVKQAKAKEDAAMIARRKRMLQTFLNRIGRHPILSNEHIFHRFLDGEVSWTEVLHSPPISLLPKNILKAPSHNPTDTTTAIAYAALPSPSATQHLRRPDQRFLDSEIFTNKFAAHLSGPMEKVTRRSMKRWSDYAQDHAELGAVLNGFSLNESAPLSTAIERTGQAVDATYMSTTRLLQELEQNWAEPLNEYSQFASIIRKLLAYRHQKHVQYEMTQESLDSKREQLGELEKSEREARRLEEALGRGRGESLGGSQINENTPRPSEEGESEEPERLTEEQSAYLPPHPGPNPVRRRAPGMGLLSALSYTLHGMMDVDPETARRNSISKTRETISQLEDALHLSAQDLKYSSSTIQADLDRFQRQKVADLREMAITMARSHRDWCKKNLEAWEEAKKDIAKIPNHPNRLPGDAEQSSPAVNGRRDSSATVNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGM2</accession>
    <name>A0A2R6PGM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000495">
        <property type="protein sequence ID" value="PSR90485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGM2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="17362" checksum="2BF888A764BEF436" modified="2018-06-20" version="1">MQPPLYHYGWEIDWKKFAKYAEDNDLRAYVRQEDDEDDEDDDEEDEETEPNFVLTYDESLTVLKVLGTLARDVGIRRLPSECALASVLGRGTIVPFFALYSNYQLAEAPSRAQLLVLQDHLRARIGETESPKWLPDYDFRWRRRCWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMV3</accession>
    <name>A0A2R6PMV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMV3"/>
    <dbReference type="STRING" id="98765.A0A2R6PMV3"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR93736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14472" checksum="9C16367F04E9EE72" modified="2018-06-20" version="1">MSANSDSNVIGVVILARHGDRQGRYQNPETYSATSTVITPLGEQQEYQLGGYLRDIYLNPNSSSYIQGIFSTPAIFNESEVIVRADAGGDGGVIVDSSQAMVQGLWPATPLQSIVLANGSSITSPLGGYQYVPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN85</accession>
    <name>A0A2R6PN85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN85"/>
    <dbReference type="STRING" id="98765.A0A2R6PN85"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="384"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR93787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="636" mass="66903" checksum="C8E8BC0626545665" modified="2018-06-20" version="1">MPTTVILGTGIIGLSTAYYLSHHLADNHEATPGTHTGHHIHLVEPSPELFASASGKAAGFLAKDWFAPAVAPLGEFSFDLHRNLAKEHGGRDKWGWSESVSYSLDRESDVDEDDDYQTSGDDDDRQDAPPHTNGEAAGASNGHAPTKSAGGSRTKGTDLGWLMNGSSRITLLDDPLTDDASGDDKDLPRWLRVKKTALQVISDRTSTGQVDPYRLCQFLLQECLARGVTLHHPAKATKLVRADPEDPSSATSIRLQFLDESEAAAASGQVHTTPNSSSPPDDLNGRINGKRRGNGGSMARGAKNSRSLGTSSSGSSSPPPPLRSSWAAFTSPLEDSSPESLNGEDDYFNNDKAKSNGSGEGVNGSHKAGENRSGLESDANNKTGRTLDIPCDSIVITAGCWTPRVYRTLFPNAGRIPRVTALAGHSVVMKSKRWSPQAVKKLVDTVADSESINKDGIPLANGRSKGRTASSTSGTITTSEASTKTVLASHAVFTSDPAGYSPEIFSRLGGDVWLGGLNSSAIPLPSIATLATPDPEAIDILINTGKALCGDDVEIVRSGLCFRPVAPTGRPVLAKMHEADLGDGAKVPGGVYVATGHGPWGISLSLGTGWVMGEMVLGKEPSVDVKALGRWEAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNJ8</accession>
    <name>A0A2R6PNJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000452">
        <property type="protein sequence ID" value="PSR94367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNJ8"/>
    <dbReference type="STRING" id="98765.A0A2R6PNJ8"/>
    <dbReference type="OrthoDB" id="2689725at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="514" mass="59009" checksum="2F477604FB3DA4E6" modified="2018-06-20" version="1">MAKALEVLDADSLCGYDIGCSFESTVTHSTLATTFKEKNARLCVNAFHGYTHCYVCQLQYHPNIIEGAGLEDLETLERVFSASNQLASITRYASAYRRRLFIDAYFKQWDEDKYLNLGTFILNNFTQAMDIIERNTPALEDAKKSLDISNEDMDSWECEEAQFFATLGNEQPYDIRQVVYVELLQDLRDAESKSARVNTRFRAFIPVTGPEFYEKQVSDTRKIETERRHAIDKVDRITRELCELEVELEISPRWTPAHSKYQEIVNFLAERKYRQALDKLQKLVIQRLFELHKLNLAQTGYKMRTHLSKSLQTRCKTIRKAVAAYNAAAAALEPPRPPLEWSKVSHYDFLEEFNLLQDTRNDIRKKRWSEPAVRETIKLRRRLERAQEKIIRCTVEVRRLHTAIRDEASLFQRVLSELQAAKDPLYIAAKDFVDRRLRVNLALLTRVHQVYELSGFTGSQGPGVCLGTTPPTGTNDSIMSPPQRSNESSDEEEDDDVQGDIGGIAEFVGGLTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNN8</accession>
    <name>A0A2R6PNN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000447">
        <property type="protein sequence ID" value="PSR94568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNN8"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015338013" evidence="1">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="195" mass="21777" checksum="2C628F5D5444AE5C" modified="2018-06-20" version="1">MFPSTILLVCSLVVFAVSSPLAPREDAGQIVLLETRPIVKPDQPEYEHGEMPPIEHTLGWVDPRLNGGRFLDFTTRRLGEPLNVIISALSDPFVLEESGLRAYANSIGFSAECLGLHYGYLHDADLGDGLGQKKEHVLMRQQYMPVFGTCWESIRGGQHFRAWRQNGTLANSGAWFIGASKEKVHLFPRLSRTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ35</accession>
    <name>A0A2R6PZ35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000420">
        <property type="protein sequence ID" value="PSR99329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ35"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ35"/>
    <dbReference type="OrthoDB" id="2793851at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015350402" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR99329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="12744" checksum="BF4AAB0B9E990225" modified="2018-06-20" version="1">MQFKLAFAALASVLAIATAAPLEERAAQVDAHIYICTDDNFGGDCTNYGFTSGVCSNFPSEFQDDISSLGPDAGWYCNVYLDYYCNNDESSLRVDYPGISALGWGNDAFSSLQCYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2B0</accession>
    <name>A0A2R6Q2B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000404">
        <property type="protein sequence ID" value="PSS01012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2B0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS01012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="7960" checksum="EB0AB874A0E2CE55" modified="2018-06-20" version="1">MTVANINLEKADTVEDVQEDYIGTFSSASRKSTGSSRCIKGSDYRRSSYHANAKTTLAPLIGTLFLPRSFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7F2</accession>
    <name>A0A2R6Q7F2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000387">
        <property type="protein sequence ID" value="PSS03508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7F2"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7F2"/>
    <dbReference type="OrthoDB" id="2804352at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="167"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="802"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS03508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1203" mass="131592" checksum="1D64AA1E20D53E07" modified="2018-06-20" version="1" fragment="single">MDSFYSIVGKDLMSRLGGGGSSSLIAILQRISVMTMECCSFIQLYISNLNASGFVAGALKNSVSSNNDRIETYCNIFDSLQQDFRDAIRVDTHHIVERMGTYFLADELSFGRENLTLILTAEYASLGDMPHVKGASLNAEGSCLEGTRKDILGVVSKWISKSPGRQPILLLTGEAGTGKSAIACSVAVEFAALGCSFGFKRGIEERCNPLNLFPTIARDLAHFDDSFRRALCAGVGNDKALQTTSSLELQFQHFITNPMAGISRPILVVIDALDECGDAKNRAQRVALLKLLATPGKLPPNLRFLITSRPESDICSHFEDPNEHYIITKRMNKIPIESTSEDITLYIRTRLITDFHSKLEGIDEACCQPLAHASQGLFQWAFVACDQIAYPPTGRKPREQYKRLVQSSSGVGQDKLLDGLYLEVLRSLFAEDNEEGTIRFKSVLAVVLAPFEPLTMTGIKAMHETLKPSDDDYDAGDILQHLGSLLSGVNDRDVPIRPLHISFRDFLTDEKRSHGFFVDEAGAQHSLGLASLRTMIKILRFNICKLESSYLLNDEIPDLQKRIDENIPSHLSYSCRFWARHLDIASTNGRIANPDVRRLLKAFVDENILFWLEVLSILGGVSPASPALATTAQVLKLDKSQPSNDNLIGCINDIQTFVDVFAQPMSQSAPHIYISAVPFSPRGSWISKQYLPRLSRTPRVCNPPEHWPASQGVIQHSDEIWNIAISTDGARIAGACGYFGVLIWDTRTGLLNSSLSNCGGSALHVAFSADGARVAYARRKGTIGVWDTESGRNWTIAVSIFGPESNDDVGCLTFSPDGRKLIAGSVFGTVGIWDTSSGDASGAILYQSIMKCRFECISFLSHGGALACGYKKNTIEVCKWDATTLQLTEQPLHIEAESSVSAVGVSFDGRHVAAGLEDDTICLWGLPEGTPVGISVSVCSRTEGRVCWIAFSQDGSRFASAGFSGTVDVWEITPTGPVLEVSLQGHTEAVQGLAYSPDGRHLFSCSFDRTIRKWDAHSTNTPDPIIPQSTSSIAGVHISHDGTRIASVSRDGTVRLWDGASGTAIGSPSRLPTRELDEGIYHSAMSRDGTRIMAVSRGMVRLLDFKGCKQTERRIELDTDYESTGVFSADGSRIYITSWNRIYPIDVDTMEEAPDSSTGKAFPVKRFYGPPVISADGAQFAVLSWDTDETVRLRILDSQTVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7I6</accession>
    <name>A0A2R6Q7I6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000385">
        <property type="protein sequence ID" value="PSS03517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7I6"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7I6"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30869" checksum="8436ED91D300AC77" modified="2018-06-20" version="1">MAGDTPFEPVAVATVRKYLAAMRAWHIAQGWPAPLSTSDMERINWSLRGLNRIQQGRRTRPPRPPITLAMLAALKRTLNLANPFDACVWAMACCSFWGMMRFGEVSVTSRNQFNPRRNITRAHVFFGHDLDGRPYARLDLPAAKTAKPGETQSVFLNQQGETCPLEALRNLARVVPAGPQDPLFSWRDRSGDIRPMVRDTAMHRVNAVLHAWGWGTSFGHSFRIGGASFFLGQGISPEIVRIAGRWKSLAYEVYVRAFEQVSSHHLANLSQRYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBG7</accession>
    <name>A0A2R6QBG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIB component B'' Myb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBG7"/>
    <dbReference type="STRING" id="98765.A0A2R6QBG7"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIB component B'' Myb" evidence="2">
        <location>
            <begin position="516"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="674" mass="73154" checksum="505C4DF83E759511" modified="2018-06-20" version="1">MSTRVQKGGPVFKPIAKPRPRHTSETRQTSLTPDPRLLPSSNGTQHMHHGSPLTTSEAASSMPPPSTIPHAPGPGAHTEGTTRPSNNILGPTLVNSRQDTNGAFAITTPSRDYMRHHTGNTVRPFVPVQNVQPPAVPPAVAINTQTTSETERISTALYPQPVHTGVPIPIATPNRSDSTDVAPLPSATDSAAGYSTALISHPMNDSQIDPALLEAVVTALQHADQAQQVLVESSQGDGQMLAPNAVNVPQPRRESAGGVEANRGQTTSVSLKPKRGRPRRSLPTNDEISSIDGENQISEGRRTRRKIRRSAETPDGDDLDSFRKRPRKQRSRAPSLPPYDPAADPGEEIDPTAVTMAELCDDTGRGRVSSKAMQIMSNHAAWRAANKGKRERMRANMEAKKYGRTLDEDGNGTLNVGPPAPVAAEQHGNGTTVGQSAAGPSSRGQSPDADGQKGDDYDYTQALATSRYNVQVRVGPNGETIIDETSLFVDRQEEDDTAGYTHIEESDTTKFVNSASYSKKLRGSRWTAEETDLFYNVGTTHRLLRIMGSNISQALSQFGENYELISYVLPGRDRKACKNKFKAEDKRDPARITYCLKNRIPYDMATLTRLTGKDFSGPTPEIRAPTPLRMPTEANEVPAVDTETAIKTRKQSKTPRPDRGEEEIIGSIEELDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEU3</accession>
    <name>A0A2R6QEU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEU3"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS06637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="801" mass="88586" checksum="5ABE7F47BA720942" modified="2018-06-20" version="1">MSSSEEKDNPKAGGSVEANPANLKTGWSAIEDYAWRNDEQSMKVFSEDIDTLLVFAGLFSAVLTAFVVPAFGMLQQDNVQVSADILARISAKLDSFQITPSFINSTASHDPSPSPFTVSTSARWINILWFLSLLFSLSSALFGILAKQWIREYLQWNQTTASPRQNVILRQLRSEAWVKWKVPAGIAAIPALLEVAVVLFLVGLIIFVWTLDFVVALVISISAGIILTMAFIITTLPAFFQHCPYKSPTGWACAFIYDMVVRYLYRIRFQFERRSISVLPYFPSWRHRDLHISRKLSTEVSNCAEDGILPWYEDSTTEHIKTIAQMRPLVQALAWVHEGSEDPRLSSEVVRCLDTLLIAGSDDAGWQLSGTLYTLWKFCSRDGRMNHFPRVGSLLDAFFDDAGSRIVHVYTLSSGLGVETYDTLIDGGHIWRALQYLDDSQRRLLINLVLGDLEACLIGKPWDTTVGNEHTNKRRRKWIANPNCADPSARHRFAMMADWLLSHLDWSDEHNPDVLLQKMTEAARISLDNSYLNCGCYHDLPWIKSLLYLGLSDYPQSMSSLFDILDQFKFVNTSSSHPLEYSDLLDESGKVVAVITGEGVKEDYEEAKATILRYLDSDRSTSRGADDLARDGGDVGEGVIDMVDGHPNPCNTPGDDGPSEGTGQEEGEVGAALDAITVSSGSESAHKGASTNIPNMAATEDAEQTQALVKCGEHAADDTSPPISRSTHPSASTDDRAFGPPNPLSGQFEGVWSIGVHDGRIGIDSEEGILEDGVEGRIERDSNESEIEMQGMSTTSRAHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEX1</accession>
    <name>A0A2R6QEX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000351">
        <property type="protein sequence ID" value="PSS06867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEX1"/>
    <dbReference type="STRING" id="98765.A0A2R6QEX1"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="843"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS06867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1150" mass="127451" checksum="5E0B2047211A28C3" modified="2018-06-20" version="1">MNIPVPDNATPSYGSLRELVGSPDQLSSYPSQSEYFTPHPYTPGVSDGNSPTDITPTAPPRPRYGRSATSSSARRQQASSTGLGLPSSLLRFSRSGPQKGHEPEWTLFSELMGNETGKEPSSNSAASRPRDNIRDLLTPLAPTAHGHRSQTSPQSQGAREPLASQQTPQSPAYDLHNSTSTIDHSPINDTLSTTTSPTRSSSLESDVSDHTLDEQPAGHDANRKKWLSLPTISPLHRNILKCSVAYFIGSLFTFSPYLSGFIADVTGRGPGERRPSPSGHMVATVAVYFNPAKTFGGMLEADTFCLVGLLFAALVSLSSMSMYWFFEVQAGWEWLADLLVILWIGLGMSAIAWMKMWMAKPTFNTACSMTCIILFIVVIKEGGLDTLLQVSLIVVVGSLISNVVCYVLWPQRATRNLQDTMTKTLDSFSTLLTIVTETFLLDEHFVGQENLQKATANHQSSFTALKKNLAEAQSERFFGGPTKPTADVSSRQHLGQAYEDAVGSLNRLGQHLNGLRSGISVQHEIVKASRGGKLTLRSHSSKFSKSNGKRKLVVQSEEVSEEDLALLQAAADAFGDIIDDLGPPLKALSSTCTGSLKRLREAFNERKHPGIQELKPEEFHELADSLERALFTFESTSNHAVLRLYRKSATSAETSIASLTDENSVLNGSDSESIFLVYFFFFTLQEFARELVSLVDAMSRICEIQKQNAERRGWKSILTSPWRLVRSSVGSFRRRRTAEKRRNATLSRRLSHYFLQEPAHRSVSFPKITPHAPNTKQTPAREELSFTGRVKQSLWALGARLKEKDTKYSVKVGMATAMLAAPAFFDSTRPIFTEYRGEWALISTNFMGVHRVLGTLLGAATAVAIWTAFPENAFVLSIFGLFFSMPCFYYIVARPQYATSARFVLLTYNLTCLYSYNLRQKDISVVDIAFHRSAAVTVGVVWAAIVSRYWWPTEARRELGKALGEFCLNIGWLYTRLVAFNSFENQPSVSVGHIEISPSPPTEATSLLGTSANIYLNDSITEFMAMHTTVRKDFILPTNQYRREMVGNVILYFSTLAAAFRLKSPLPPYLPPAEIARLRLVDALRQLDVVKNREVKGSRQLLFFAYALTMKGVIQELDYLGRTLQDTFGVIGESTEAFEALFRDTAHEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEZ1</accession>
    <name>A0A2R6QEZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000348">
        <property type="protein sequence ID" value="PSS06887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEZ1"/>
    <dbReference type="STRING" id="98765.A0A2R6QEZ1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="52"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS06887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="581" mass="64996" checksum="9820BD7A1F3D3F17" modified="2018-06-20" version="1">MTDYDSEKHPVEKISETSSDVLPDVDGTYAREELIDPSKEETLHRSLSARQISMIALGGAVGTGLIIGSGTALVRGGPLGLLLGYTFVGMVCYMVMVALGEMSAYLPHKKGFPGYSTRFVDPAFGFALGWNYLLKYLIVTPNNINAAGVVIQYWNDSIHIAVWMVFFVNLLGVRVFGELEFWFSSIKVITLIGLILMGIIIDLGGNPGHDRIGFRYWKHPNGPMGHYLLDQVHSEHLSIFLGFWATLTNALFAYIGTELIGVTVGEAQAPRKNIPIAIRRTFFRIVVFYIGGVFVIGLIVPSTDNVGLPLVTLYKYVHLSFRFLRPYLLPTNLRLEQQPLRSSLVSFIELPGNPYFTLIECMRSATTLVGIKVLNHVINGCILLFVLSAANSDLYIASRTLYGLAIEGKAPRLFARVNRMGVPYPALILSVMFCGLVFLNVSSSSSKARLGVPMLTEGFSRFMKALKAQGFSRDNLPYKAPFQPFGSWFALISTGIIMIFKGFDTFIPFTTDTFVTSYIAIPAFVLFWASYKIWYRTKVIPVERVDLITGKREIDEEEERFNHEEAMKGPRTKWEQVWDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIR1</accession>
    <name>A0A2R6QIR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000333">
        <property type="protein sequence ID" value="PSS08886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIR1"/>
    <dbReference type="OrthoDB" id="3026189at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS08886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="23265" checksum="636227FF49C3D52B" modified="2018-06-20" version="1" fragment="single">EMAPPRTSNTRRQGRHAVDDAVVDSSDSEASQMVPPRPTTRGQRRRARQEVQPNTSDSEDDYTSSNYVPPAPVRHTIPPPPVRHTIPPPPVPNHLPPAPERGRYASFNSRYWLDRVVRKVQPPSKWSSHYPRPGMTYITLTEVLCWQDGLVGCDTDEGKYVVTSPNAAHIPRPSYGAVTLIRRWDGLFGAHDPVLWPQVVVNSGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R124</accession>
    <name>A0A2R6R124_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-alpha-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R124"/>
    <dbReference type="STRING" id="98765.A0A2R6R124"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="325"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="423"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS18928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53353" checksum="29835FEE1BAB1C27" modified="2018-06-20" version="1">MAATNGFNAALRRRLTDGLLHTWQGITGSLPHPLLFSHLFTVCFMPETGVNQWPPPSPILAEGELQSALRTQEEKEAKRINDEIDRQIELERQELKKRKPQAKILLLGQSEAGKSTLLKNFQLHFAPKAFEADGEAWRAVIHLNLVRAVNFILEALATSPPPPPPSVAVSSNRSVSSLSNYARPNSGNPFRHLRMRLSPLRQVELILTRRLCPESLPDQFPGDGETSTASKKTIQTGDVTVRARSGWKSLNRMQRPTSTTHDELYDARQIIEACCEDIVALWADDNVQAGLLERDVSLEDNSAYFLECASRIASSKYLPEPNDILRARLQTIGVEEHRLTMETVDPGQEWTFYDVEGCRGQRAAWAPYFDDVNAMIFLCPMANFDRVLAEDPTVNSLLDSFQIWKTICESKLLADATFILFLNKMDLLKVKLNAGYRHNVNHLDASGFSVWKSLDWQFPNHNSVRVKRIRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R775</accession>
    <name>A0A2R6R775_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000279">
        <property type="protein sequence ID" value="PSS22597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R775"/>
    <dbReference type="OrthoDB" id="3265536at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS22597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11779" checksum="1E7B26263B849468" modified="2018-06-20" version="1">MAHLPNWPALPQNTSGIPWSANVHNAYKLLENIVVHASQLASHRESDELQLSYYIDEVTSRALPTLEALEASDEQLPSLWLHDCAEHLGALIVALRSTRDRSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7C2</accession>
    <name>A0A2R6R7C2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v3034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7C2"/>
    <dbReference type="STRING" id="98765.A0A2R6R7C2"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000051">
        <property type="entry name" value="F-box and WD-40 domain-containing protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS22668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="597" mass="65439" checksum="4A4FA36987EF4855" modified="2018-06-20" version="1">MCCFSQLSLLSEQLAHLIRIDPFTVLPSEVSLKILGYLDATSLCRAAQVNKRWKGLADDDILWRGICEQHIGQKCLKCGWGLPILEKRRVQRLPSPQLTSSNLPVTDSKKKRELEKSSTLNEPPLKRLRSDPAEPCSESHHESPSTSHASHSPSLSPLSTSDSSNMLNPLLAPNEPSRDTCTRPWKDVYCERLTIERNWRRGRCTVRTLSGHTDGVMCLQFSETLSHPSFPILITGSYDRTARVWNLETGREVHRLTGHTRAVRALQFDEAKLITGSMDHTMRVWDWRTGKCLRVLEGHTEGVVCLNFDSNVLASGSVDTTVKVWNFRTGECFTLRGHRDWVNAVQLWNPNDVTPSGCSSSAGLDTSSSPSSGSSAPTIDPGKMLFSASDDGTIRLWDLVQRTCVRQLTGHVGQVQSLKLLMIDEPSDDSESESSSKALSTASGRQTPDPRSAAPALATVSLPGTPPPTSNSDVSTGFNPYTFLHNSTDTSASRVIVHPVDNPETSTGQEKAVAAAAANERTLPVPAKRVKPVLISGSLDNTIKVWDLDTGKAVQTLFGHIEGVWAVASDKLRLVSGSHDRTIKVCHPCYPDNLKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLL7</accession>
    <name>A0A2R6RLL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000243">
        <property type="protein sequence ID" value="PSS30875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLL7"/>
    <dbReference type="STRING" id="98765.A0A2R6RLL7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS30875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="73994" checksum="4B5F596D46E919D2" modified="2018-06-20" version="1">MLRGIKPNCKVATNVFFHTHLNEIDMSESMIRILPRSSYQNEPKLAAWVQTTVLHRDGPSSADFMEIIATFTPCTSMTMLSRHSKSNCSFLSEGPLVVPQCSRRDDDVEGHLNIYQLTSLTHNDTRASKSKDSKSLCSQDGTFARSHPHLRKAGFVLVGITPGHAASVRLTCPSGNVRQFGYQKNAGDLDFAWMNEYGAAYRIGGTLGEDILMVSDPKALQHMLHKSGYNYPKNVETTVGVRLVSGKGILWASGHTHQRQRKIMSPAFTAPQLKSFLPLFRRISGKMCQQWNEEYFSKSPAGQTIAVNTWLARVTLDVIGEAAFDFKFGALDDDENEVSEVYKNMFVDSVMHPTIWNTLFRSFWRHMPSALLEYVGYIPTREYTRFRKAMQVIGRVSKQLIDEKTKSYSDGDDTRKDAMSVLVRANISENPKTRISEEEMISQMAVLILAGHETTASTSTWFLWELAKHPEFQDKLREEVMAVRSQISARGDSELTIEDLDGMVYLPAAMKETLRFHPIVYHLGREAAKDDVIPLSKPIYGKSGEMISEIPVTAGQNIMISICAYNRLPDVWGNDANEWNPMRFVDASDEKQVKVGILANFVIEMQAIMFDLVENFKFALAEDKPEILRVPMGIMGPMVEGKMHEGVQLPLRVTPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLP7</accession>
    <name>A0A2R6RLP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000231">
        <property type="protein sequence ID" value="PSS30954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RLP7"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="7">
        <location>
            <begin position="669"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="8">
        <location>
            <begin position="1598"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2018"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2061"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2108"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2018"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2030"/>
            <end position="2046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS30954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2176" mass="244158" checksum="8E0FC6379401431E" modified="2018-06-20" version="1">MSGQPPSRRGLWEPLPRFIYGYAVHPLSPSRRDTRLSNRTFTRPVSSFTDASGDEHLVHRDVVSLEVGDEIYAFERYTPRDKEVEGVWYRGYVVCTSRRPPVTWQTSTDPSTSASKAPAKVDETQQVFIGIFPQSHIFVRDELPDAEGRLAEMASSFNSGPNGYTPAADLYAQWNRDKVEMDEEDGDTQSVAPSIAPRKSSFKLTPPPEQANSTRARLPVYPASLRSVSPTSQVPKPLPPRPSLRPADDTASGGEQPIIDEIASALREWHMLMFQYLARRDYKLFEVIRDHIEALHLGRRQLLAQTLSAEETVNLRRQCVARLVSGNILQGLDVIVRHPSWGGLVTVDVEGELDSRSWVSAVRMYAMQVSLAYMDVSTSNVEVPSLGASIDYIPMNGPQPTPAHSTFADVSRSRSQSKSLGSLGRSPDPQPSRAKFYHVFLDLRAFVASLCAAGESVELFFSLYNKNDSTKVSEEFCAVLNSNGALARDPDSRIRTLFTDLVPQDAQAPIYLVCSIVRNGAMKMGSSMGSIPEANKRSSEISSIVWNESSDSNGLPSQFRRPFGCAVLELTQLKKMASEGIEVSSTREHTIPIYVPTNEATFSTLHQDILNGNFKEYEKSTRAETLAVSVKIFYGDSDTIIRENSSLLQDTPLTLRLGFPDVVFPGDVRNEFYVKLWSGDFSASQTSSARRSVTNFARGHVGTVSGNVQVTIEVRNQDGQTIDHVITRCSGEPEVSQYNSMVFQRTSQPTFGELMKVKLPFQGAQQWHLFFTFRQRNTRERSLGRGATDVPERPFAFAFLPLFPDGRAFLEDGTHTLALYRADRLSQLTAEQYLAAAPWIIGNQRPEHVAVPVDMQRSAPLLRDTFVIRSSLCSTKFTQNLVLLSLLNWQTITDKELLCTILTKFSFVGEVEIVKFLRDIFDALFAILVSPVNQNGEMDHLVFNALVTVLGIVQDRRFSNFQPVLDVYIERHFNCAAASSHMIHSMNMLLQNPTASETASALRAALKVWHPIFKFIAHSRELQKAKELGMGGGATADHLETAFKKELHSHLAEINRMMSTTAPASIIGTQTIALRHFTSILPELAKVFPTMELVGIATKFANAIVVTKGKIVIWKLIMYLQLVRGFLFDIPQARSMLVESVVIWIKPHFGRFDEYVHTQLGDSESARDAARIDWLESIRLSVTVVAVMLDKLQQSLVNPTILADRNLLRQEQYNVEYLLSLFPRLLESYLEFLSPANQRAMDRVRSPSTIPSISPVTFPESYPFALVSNLPKNAQNTSPLPSSENKAVYNPGLGETAIVLLVLALSSPRKYLLNFLEGIYDIEGRDNLSAILSRLFKVAASILNNDAFPSNWLNVNILAHQVLIKIMDPVGTVLERTFIPNEQANFTFDVALWKEGFFVLLKLLSSQQLVIEELLPQTRRAVWRLAGDIRGEGAAILLRLWSALGWQLDDSTDSTTASRFGNYQIALSPLVGHVVNLCLSHHDQLRNNGVHILYCMIISEFHVSGNFDNIEYELVSKLDTLFMSDSKGDDISRAFFITHLRHLFDSSEVDVELRTRLTNFLDAVDMFLELLLSLRQLPEGEEFADDRVIATLRLMNFIRRIGRDEIYIKYVHQLVNMHLQSQNYVEAALTLKLHADLHEWDLNTFSPPMEDLGLPQQSQFHRKETLFLLILDYLGKGKAWERALEICKDLAFQHAEVTFNYSRLAEILRHQASLLEHIVTHQRYYSDYFRVAFYGNFPDAIRTKQFIYRGFEWEKFGAFCERMLNKHPGAQLLKTMGDPPADIRFGKIGEPPEDQYIQCTAVSPEPNRDLPIFTNPDVPPQIRTYYEHSDISLFSYSRPVTRVGPDGVEEVWYEKTYLTTEEAFPTVLRRSEVVDVAIVEISPVETALHEVQVRTRELDGLCQRYSALAKTAQVVPTTPLSMTLNAAVDAPLDTGIALFRQSFLTGEYVSRYPDRAEQVDKLQTAIDDQVRMIDSCLKLHGQLCPPEMLAFHNTLESFFRKNFQEEIQRLAVGSHSLDPTSFSTRNVQTSFSPSHSPSQSQQRSSPDTIAVNRQQFALNPLDLGRPFASSPPQSPRFPRDNGHLSVDGGISKQTPLQRGLAHLARHGFNGVASGPRDNADDIEEDSPRDSFVNGSGPPVANLSGAASLNTSTMGSMGSLRGRFSRFGSLNFGRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPI2</accession>
    <name>A0A2R6RPI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000214">
        <property type="protein sequence ID" value="PSS31931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPI2"/>
    <dbReference type="STRING" id="98765.A0A2R6RPI2"/>
    <dbReference type="OrthoDB" id="2733714at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="300" mass="33594" checksum="8F8A67AFF8BCE2C5" modified="2018-06-20" version="1" fragment="single">MGGYAFDASVKPKFLPGSCTRAILTPKGVEWLMVHNPTLLPELSKEMIMDKSKADGLAKLILLVQSCWFCVNCLTRMAQRLPLSLLEVTTVAHALCTLITYLLWWHKPLNICQSTLIFGENARETCALMWMTSPSKLYCFAGMLQSKGASELSSLASSALLVQDTIRTEPNSAPRLQRILETASKAWHDPRWNGCSDTSLSSQTTIERWKLASRALSDYDPEHWYSWGQLVTPQAELRGDLHAQDIFSIQAIAAVAVLTAVYGAPHLAVWDAEFPTHLEQALWRFAAVVYKNKQRRQVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPQ6</accession>
    <name>A0A2R6RPQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPQ6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="16546" checksum="148AE20D263C943E" modified="2018-06-20" version="1">MPRHLASTWGTEDAVDAIPTVAAKIDTTITATHTVIAATAIVNATLILGAMIGTTGTETTMEGTGTGVIAAAPRLPVVVEAATLRITEGVGAILGARLVGAAQSVLGNMMHRPQVLCLPPTGQNLAGKAAALWYDFVVPSPVRHVYGMNCFGKTPYQVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPQ7</accession>
    <name>A0A2R6RPQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPQ7"/>
    <dbReference type="STRING" id="98765.A0A2R6RPQ7"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="265" mass="29882" checksum="E2816F250143FF95" modified="2018-06-20" version="1">MDTNDPRLFIAAALIGLGALLLHRLLFRVAITPPSVSDNVSPKQIGSTTAKLFTNHGSRPAGEWIPVDFDYPHVDKCLNAVSDIKPIPYRPFKWGDYHVTMGIRSMPWDDWVELDNQFLQYHRIREERVKTKGDRLIQTLPATPGLVDSGRDAGKRDSSYPASPACSSRQIAKELVQELAEYLSQRFPDVYIIVRHDSDKDSSGWHGQSSIKEITIIPLRKTYKLDEEDPMTVSALLFVLPLNYKAKHDLMIAAVQYPGGPRDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ21</accession>
    <name>A0A2R6RQ21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000198">
        <property type="protein sequence ID" value="PSS32089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ21"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ21"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="45"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS32089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="371" mass="39977" checksum="0115BFC57FFC507A" modified="2018-06-20" version="1">MSDSKHLQNIPAQNVPYFTPAQIPASGTAVPPSDVGGIVSRGPGLSFIEGTAVVPEGRITPEDLGIWSDEHIPAFAELTTFAHSQNQKIAIQLAHAGRKGSTVAPWLSLDQLATKAAGGWPDEVVGPSAIAHSDRFVTPKALTKEDICGIVQAFEDAARRSVQAGFDVIEIHGGHGYLLHSFMSPVSNQRTDEYGGSRENRTRIIVEVVDAVRKVVPKEMPVFYRISATEFLETTMPDTESWKVSDTIKLAPILADHGIDLLDVSSAGNHPLQSLGTVRFVEAYQADLSAEIKAAVGDRIIVGAVGGITNGKLAQRILDQNKADVIFVGRQFQKNPGTVWQFAEDLGVHIVGAHQIEWAFFGRGVGRVRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVJ1</accession>
    <name>A0A2R6RVJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6RVJ1"/>
    <dbReference type="OrthoDB" id="2218151at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="49"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="366" mass="39500" checksum="3D4D1ABC3F7B3E1F" modified="2018-06-20" version="1">MPFTDLIQNTLNRVLPEKRTSLPLQPSSTGGIGGGGHVPFEDDMIVSKPAIIFHASQAFFNFLAMCCFASVAAFQAKWHVGPSGLTGFAVFISVIGICFSFFMLFVPVVYEKYDKGARLARALKEIRVGFILAGAGTVISLLIAFITTISAWTEPGCKNADNDPHAKQNGKDFTNALPGWCSTKKAGAVFFWFAFVFWGATLGLTIFDWRNGKGLRPRDPPFSHPMEEPEEMDEEESIYEHPGARSSDKYDDSNLGQSPFSDNNRYAGVPSVGPSIMSNSTAPVLPRPSIDAYGAFSDPAPNGFNSIPPPQSFASPASPPPDGPRVSRTMQYADPYAAIQATVARGQGVSPPASPPSYSTSYGNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVK4</accession>
    <name>A0A2R6RVK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000161">
        <property type="protein sequence ID" value="PSS34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVK4"/>
    <dbReference type="STRING" id="98765.A0A2R6RVK4"/>
    <dbReference type="OrthoDB" id="3269417at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="177" mass="20029" checksum="803486BEA695122E" modified="2018-06-20" version="1">MLGAKLRHLVNNICPHYHTKELPGEEVARGRCKAAKSAKVTNQPATQVGTAVSTQNRVQGPKRKLLNLCTYKLHALGDYILQILWFGTTDSYSTQTSELQHRRVKHFYARTNKNGANIQIARLQRREELLQRKQAQVHKHLLSKKTQAKVQAALAQDELELLAYTPPITYPTLATSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVT4</accession>
    <name>A0A2R6RVT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000151">
        <property type="protein sequence ID" value="PSS34133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVT4"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015326520" evidence="1">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="141" mass="14549" checksum="4D824986B5D999DC" modified="2018-06-20" version="1">MLKSILFLATSAVGIVAQTVSVNTPRPGDTISASSSFTVEVQQAKIAGEVDEISIFIGIAPCSGGSCDDVGQVLYNGAYDPQQDPNNIGKGLFEDFLVQLPAGYPTGDSVLTVFHIADTQAPGGPLVPIFDSTTISVTVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZK1</accession>
    <name>A0A2R6RZK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v1610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZK1"/>
    <dbReference type="STRING" id="98765.A0A2R6RZK1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS35455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="366" mass="39596" checksum="5CB9F3E5A9067987" modified="2018-06-20" version="1">MAPSRYFSPAVSNVQNMQTFARNILATYNQFNLDGIDIDWEYPGQQGNDGNIVNANDTANYLAFLQLLRNTLPPTAKITAATMTIPWADPQGNPMTDVSGFAQVLDWILLMNYDTWGSSASPGPNAPLSNACHNSTQGSASALAAVEAWTSAGFPPSKMVLGVPSYGYISRSSETVLQTRHIKHRRSKTHHTPIHDLTEKILPLPSDTDSPPLYADAMKPTPATAPGVLVANDDGGTDNGQVQFRDLIDQGILQYIPAIPAFGPNSTSTDPETSAELTRIAFAGQQITNLFTALSGFERKWDACSSTPFLQSSSAKQVVSYDDPQSLEMKAVFVREAGLLGVNMFDVHGDTDQWDLTDGIRRGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZR2</accession>
    <name>A0A2R6RZR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000122">
        <property type="protein sequence ID" value="PSS35513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZR2"/>
    <dbReference type="STRING" id="98765.A0A2R6RZR2"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000486">
        <property type="entry name" value="Pumilio domain-containing protein c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000842">
        <property type="entry name" value="Pumilio domain-containing protein c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="446"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="571"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="750"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="811"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="885"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS35513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="904" mass="95475" checksum="A81049187E1D488D" modified="2018-06-20" version="1">MSLSASDNNGSFSRIPSGKTPPPAPSAAFAKRAREMEGVEDRIAARYRPPALRALASGGSPPNDSPSSTTPVGDAALPPANYPAGFRRARAGTLPSNVQLAAQRFAAASSTLSSAAESTESFSEQLQQRQNILSTANSSAAPVRPGLRHATSVASSALTERNSRLRSGSLTLPAAGIANNPFGPSFFSSTWLSGNNGLHMWEDPHSVASMESGGDDFDVHTLDYLGLDDTHRPPPAATITELRSQAQAAIAGNLATNPSRLRASTVSGSYRLGGSAGASLLSTPNAEEEEEELYSNDLYHSQLDPYDDGSSNYLSSGYVAKGFKNAEHLGVGLASRPRAISVGNLDDPSRSLHRRLAGGELQQSPYANDVPSIGLGAGALTPAGILRSDKLNSRNSTGASVHFPSGELSSSRGSPYLAAPINQGQGRAVSPKSSDGSATQMQTPTRSLWIGNLDSSVTSEQLIHVFAPYGAIESLRLLPEKECGFVNFVDQADAIRAKEDVLNRLGGDIGMPNGQTVRIGFGKADSAPVAPAKGTNLNSPVATSPGGLNKNNANNVGLAGMDAQLQSTPTRALWIGSIPSTTTPATILSVFSPYGPIESARVLTHKNCGFINFERLDDAVRARKALNGRDVLGSDVGAIRIGFAKVPVKNGQEGTGQDEAVAPNVTGVGDLSVGATIHALRNVKGAATVPVDQQVLSGAVENYRSNLLLSMIGSGLHSAQFDLANKVAGWTASVTEQQLIMKELSGGSADAEMDIQTLSEFRPPTMYYTTIPLVSERPHNRRWDASKLRELRKRLDTSNITVEEIDSVAADFLDGEIVDLASDWLGNTVVQKLFEKCSPGPRLAMLERIAPHIAMIGIHKNGTWAAQKIIECVQTPEEVALITQNLRPYVPPLLLDQFGNYVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZU3</accession>
    <name>A0A2R6RZU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="8">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1542</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000122">
        <property type="protein sequence ID" value="PSS35517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZU3"/>
    <dbReference type="STRING" id="98765.A0A2R6RZU3"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="10">
        <location>
            <begin position="78"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="11">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS35517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="480" mass="54549" checksum="5F994CD84E2D713F" modified="2018-06-20" version="1">MWHAQSEVDGEVLEVNTDECLMRLRYGQYVWQTEQLYGKAAAEIVQVIMDNGKLRSPDIISQLSIYDPVKGQTVYKQALHKLVDATYLKPSTVLSHVSPRDKRIQYEAEETAKISGFPTAKELRQAKETAEARLRREEEEAEKVGMKRKAKDQGSHRPPKRKAVEEDVVDEGVYFRVNCEKFNIHIRNKIIENAAKERFNDCAGLVIRAALKATEAKQLKLSDVRSDPTSLASIATHISEDDDLAPGLALSSSKKPSEMALIKDYCGILASADNPTPTGRATSFISLTGSKVQIEFEIIRTRLRRRILEAVTRERHGDDGVRILGLLLDTGKLDEKQISKVGMMAPKDVRPLLTAMAADSLISLQEVPKSADRNPARTFFLWYVDLQKAYTVLISNLYKTLYNIATRRQAEEEEPVLRAVLEKRERSDVSQDEERLLTRNEREVLGQWEKKREKLTVLEMRVEECVFILRDFGTFGINDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3C1</accession>
    <name>A0A2R6S3C1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3C1"/>
    <dbReference type="STRING" id="98765.A0A2R6S3C1"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
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</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3Z0</accession>
    <name>A0A2R6S3Z0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetylglutamate kinase</fullName>
            <ecNumber evidence="6">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v1152</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="6"/>
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        <property type="protein sequence ID" value="PSS37010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF619-NAGK-FABP"/>
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    </dbReference>
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        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetylglutamate kinase-like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AceGlu_kinase-like_sf"/>
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        <property type="entry name" value="AcgluKinase_fam"/>
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        <property type="entry name" value="AGPR_AS"/>
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        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 19" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 19" id="KW-0521">NADP</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="21">
        <location>
            <begin position="338"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSS37010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="892" mass="98210" checksum="D6C7012551AA8D06" modified="2018-06-20" version="1">MLAVARAAKAAGLRTPQRALMVAGQRQAVHAVRRKQPMLQRGLQSIAQTDRDTITRLLYSIGTKREVERYLRIFSSSSDASNPAKFAVIKIGGAVLDQIDELAASLSFLYRVGLYPVVLHGAGPQLNGIIESEGIVPDYIDGIRVTDAKTLQIARRVFLEENLRLVNALEKLGTRARPITSGVFSADYLDKEKYGLVGKITRVDKRPLEASIRAGALPILTSLAESDAGQILNVNADIAAGELAKELEPLKIVFLNEKGGLFHGVTGEKLDVINLDEEYDELMRQPWVKFGTKLKLREFKELLDHLPRSSSVAVISADSLQRELFTDSGAGTLIRRGYKLFKHRSIEAVGPDRVRQVINDRDPDVLAGDQSVTGVLNELKNAPYTIYGDEPMDVVAIVTEPEGETPVMTKFLASRSGILNGTIDNVFNAIKKDHRRLFWTARADDENRAWHFERADGSFTRSGKSLFWYGVQDVKEVERIVQGFEENGRIDRTYLPVGPAAPPHRAPSGVRQFSTLARRAFPGSSRGYATAAAPPTKRLALIGARGFTGQSLTTLLSSHPHLELTHVSSRQLEGYSLDEYTKSSLKYSNLSVEDVERMEKDGEVDAWVMALPNGVCKPFVDAIDRGVKERKSGEGSVVVDLSADYRFEEGWTYGLPELYSREAIRSAKRISNPGCYATSTQLLIAPLLKYVKPGVWPTVFGLSGYSGAGTVAGAPAVDGRPTTEPKVTPDSLAGGVRPYALTDHIHEREAGRHLARLLADPNGPMKVAFVPSVAPWFSGIMSVLSMPLNQRVTARDVRELFEAKYANEKLITIKKEVPSLPDFERKHGWTVGGFQVHSEGDRVVVVGGLDNLLKGAATQCLQTRKPPTKLEWEAVGAVESDRRERRYVIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S650</accession>
    <name>A0A2R6S650_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S650"/>
    <dbReference type="STRING" id="98765.A0A2R6S650"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="175" mass="19837" checksum="0062AC23F57584A4" modified="2018-06-20" version="1">MPTLDSLSESESTIDLWTGALEHDWDRCHAALKRLGRDGRQLELWRQWLGPPNVPIVPEKGGRRRRWTEDEYASTGACEHPQCPTNFSQDKLGEDAGITVSRAPREHITEMIRNHWTTILASFTYPESRTHFIELLSSVGLLSEMRLEDGPFGSGPVLDFWSSSQSLQNLVEHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S681</accession>
    <name>A0A2R6S681_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000030">
        <property type="protein sequence ID" value="PSS37798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S681"/>
    <dbReference type="STRING" id="98765.A0A2R6S681"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="7917" checksum="D15E621D3D38C5C3" modified="2018-06-20" version="1">MAPISVKIKHAGKVHDVELDVDLPPAAFKEAVYQKTGVPPERMKVMIKGGVLKVCFAFMLIPHSPYPWRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Q8</accession>
    <name>A0A2R6S6Q8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Q8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="677" mass="75603" checksum="DADD7AD5A4240F3F" modified="2018-06-20" version="1">MDALPVELLCAIFTEVEKEDLPSCTSVSQQWRQITLPLLFNDLRISFLQDEREEPATLQWHRTNSPVLLPTFLEFLKRSPDIATYVRSLALTAWTDENGLALVQDSEGPELHEDSDSDDSEIDLPVALMQTNPETLFLVLVQLPSLANLKLIDVAVGENHEPSLELVVDRHLDRLSLIFEGLISKHYQGQTLPKHILRPLSFFRSVNALSLSDISMHDTSLVDGSGMAGWPLPQYAFKHLEILDVFTPGLLFSTLMLSRSLFQSVETFKMQNIIHSGHIDMVVFENIIAQVSPSLLYLEPPDFELLYAIFAQMGKQDLASCSLVSGQWRQITLPLLFEKLYIRYSVANQGMCESEDKDSTFPSVFLDGTDNDDPVTLDWERCPSDAPLPSLMAFLKRSPDIAASVHFLALHQNGGTGATNPDMLCRMVGENYQPSPEPIVNRHLDRLGCSFYHTDCATRSLKTVVRVLAFFRSVHTLSLQGISKDEALEDADIARLPMPLYAFSHLQVKNVALLPFISLMQSKSLLRNIETLDIEKVGDRSLYRDPQALGSLLVQMSPTLLHFVVPEPLHTVILCLTVAMDAEDAADRLRGVGPDIMRLEDTLLALTTASLRQVVLSFKTHCTGKVGMSQGVVSYFTDVFPRLHKNGILKVYLDNAETDSVLIPTHLALSPSHVCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6R9</accession>
    <name>A0A2R6S6R9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000015">
        <property type="protein sequence ID" value="PSS37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6R9"/>
    <dbReference type="STRING" id="98765.A0A2R6S6R9"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="619" mass="67949" checksum="21DF2D19DE0E3573" modified="2018-06-20" version="1">MTARFRSRTFLEQDFVLLIEAIGLDAPRCFMEFDNRTTGSESVAMQLVLMPKFNLPPIRQQEYIFLVDRSGSMDGARIESAKRTLIMLLRGLPTQGIVFNIFSFGDETDGFWKTNKTYSQVSLAQAAHDIDATVGVVTHAVQQSTPNAPLRVFTLGIGETTSTAMCEGIARAGNGVCLMAATPESIVGKCSKLLRAGKTFLLKNISIDWGIPSDLQGSDHATPRVVQFTSLDQTMWQTPSHIGALYPGTRLIIFALIKSDRFTPPNEIYLRAQRDGTGDELKFSVPVEIVKFEEENSSSLLVHTLAARRLITELEDESRSEMTPDGERAASIIKLGERYQLASRYTSFVAVEAQETDSSQTPLPPGMVRPRPHGSHSPHQSSRNNKIHWQRKLDSYLQRAFGYVGGFVSAFIDTWVGPPPENLHSHTVPGGDLHSRPGSPVDYDVDEDDGEGDETDRTFTTLSSILGHSDSEWSEAESRGASPIADQDNARSQSPAFARAQTAPAPTQGGDQSVPLPPVDDNVVNLVRLQSFDGSFSPDDSFKGIVGINAMQEGQSLGLDPDLWATILAIAYFQKHLSNQPELRDSLAEKAREFALARLPSGTDFASLVKRAELVLQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6X6</accession>
    <name>A0A2R6S6X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v91</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000008">
        <property type="protein sequence ID" value="PSS38060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6X6"/>
    <dbReference type="STRING" id="98765.A0A2R6S6X6"/>
    <dbReference type="OrthoDB" id="3193353at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="348" mass="38904" checksum="BD8283657A345010" modified="2018-06-20" version="1">MATTLGLDFDSSDPNTAFTSLTSFRSVRNCVKLHGSTFLASNDTHHIRVFDADTGHLKYVLRVPLLNDDPTLHPEEFRCLAAIVMEGFVLIFRQQWIHLYPLPPSQAEKAEPNSSAQYVPGILPVANHKWQWHIDTLDVIRQQSHPLMSQFENETNLIAASAPPMSLLLRFDSWFPWPVNILHQFILPHNPAFNPSASAPAGTELPYLLSSLSSEPLRPYVVASIPSPIRIFTPSDSILGRHGTALWLDAQTDLSTPSQAGDRGQRIAGKHLRFDSYRHAAIEEPRHAVDLHVESSTNFHAYEDGSTSQIQIFHTQDEDNWGRLAVCEEEGILAVGSVDGKILIYEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S711</accession>
    <name>A0A2R6S711_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v97</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000008">
        <property type="protein sequence ID" value="PSS38066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S711"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="431"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS38066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="896" mass="100400" checksum="DA762AEC947C65BD" modified="2018-06-20" version="1">MPEHSPPPGESPPGPAGVPQVIHASRKARGSTPALMKASSSMTRDHKTDSIHPFVQQDLEDSLREVSVETWVEGVLGVSPSRLGEWAAHIKKLDWFQDHIIGRALTDYARPTEESEIYKPFARITNRIIKLARGALPGVGDSYPIDDIKVVVNNRTTIERIPEHGELGAFRKPDLLFVRDPQKNPSRVKGARVRWVDILAFLEFKLDHKGQLLHTLNTCRYDRGLSIVKAKREKQDRSKDTESPAPKRRSARIAKGASMSSYRGSSGPSSAGSKRSIDDVLDGDRDQSRGSSKKQKCDSPNSETIRKNVQLQAGGYALELASCTYGTRVFSLGSIVRDDKMSLWYYDASGYVRTEESVSVMKDFEKFAAIMVAFACGEPKHWGALPDVISPPSSAPYPVSFPPPSLKGHSLEMVPPDTEEPVKVTLGKPVFTQYGLVGRRTFLYRIKTNTVVAQTPLVIKFSYQVVARKREQDMVEVARKAGVQHIPKVHMWCDLWKLSDGARAIFHGGDNHAYEDRMLRALVYTRYLPLKALFKTAWHLIPHMADQILDCLHDLRYKAKMLHRDISANNVMFEIRDGAVKFIVIDFDLATMVDSNGEPLAAPSAKHRTGTLPFMAYELLDDMSRLRTPGHRRIVHRLRHDFESLFYLCLYCILTMVEVEDAKIKADTLAQLKDWEDMALHGIASLKLCLCTDVKRINEHLVFPPSCEVLRRWFIGWVYVFDNALTAVKTYDKSQLMAEPHRTLATQNFDIDTLQGTITRDTIKLSLRSYYEHSLRPEDLLVANIPGLGKDVEAYMHDDEDMEGQNKHVQKQGGVAEKATPTRKPKSTAKAKKVEVAQKKAVPKATVAGTKITTATLVSPVRKQIPKQAVAPKRAARTLAAAARSMTTRSMRKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S724</accession>
    <name>A0A2R6S724_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v78</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S724"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7476" checksum="BCC10E99DC08E840" modified="2018-06-20" version="1">MHAKVTCDATKHICFFPTKTVLGFQETDHVANCVSRRLTDIYQGTSYEYLYGEEVDCGLYQGRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDM2</accession>
    <name>A0A2R6NDM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001355">
        <property type="protein sequence ID" value="PSR70406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDM2"/>
    <dbReference type="OrthoDB" id="3185595at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="143" mass="16092" checksum="33AA7375B2C4A993" modified="2018-06-20" version="1">MTNHFWLVWYRAQSPMGPKHWSLFVTYDTDEQALGTIYQVEGNGWGTGQFTSKTCRGVQLKGARGSQAYENRLYLGEIRDGVNGMMQEYCDAATEMINEHNISKTDVSSREGRSSGQMLAQDDEQARGTFSFGSSWTIIDVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDU6</accession>
    <name>A0A2R6NDU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSC1/OSCA1-like cytosolic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDU6"/>
    <dbReference type="STRING" id="98765.A0A2R6NDU6"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="3">
        <location>
            <begin position="93"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="452" mass="50561" checksum="5AE68666C2E89026" modified="2018-06-20" version="1">MVTNIPPSLRSEKDLKEYFEYYLSRPLVKSTMGVTSAVQPGFIDRSLAFVFNKTRLLASRLHKWYGDSGITHSAAPEESHGDNKPNTCEAPLIERVVLVRKMSDLASLLEKREEVLKNLETAHIKLARNALKAVSEALGPKSKTERLRSAANSLTFGQLASTFPTGSLDLEAGTDDGADEGEDRLHLLVRTLAPYVEDLRSTGHDSHAHSRWPRWLRADKASFPCTSSTQKARAKPEKTVWEALLSLPRSTLDAYQPLIHLSALFRGKTVPSIDYYTAKLNLLTALITEKRAQSTASYPAMPTAFLTFADPADARRACKYLAVHPNNPVNVCLVTMAPSYEDLDWTRLMKSTFRVEFVKDWVVNMGVWGFTIFWVFPVTSIVGLVSIQNISNFWPGLVCVSLQWTSIVANGRYIQKNYLDRHEFQSEVLQSLVPTLLVSGLALLVPLILRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFN6</accession>
    <name>A0A2R6NFN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFN6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="6523" checksum="3CFF178D037E126D" modified="2018-06-20" version="1" fragment="single">METARTTISRSSCMNPMKDGRKTWKATRLVYATMWRLGNRRRKILEKRLPQFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFR0</accession>
    <name>A0A2R6NFR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFR0"/>
    <dbReference type="STRING" id="98765.A0A2R6NFR0"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="383" mass="44543" checksum="E62258EA392C24D9" modified="2018-06-20" version="1">MATIQDVPPEIMGQILTELDPTDVASVSQTCSAYFDFIYHPTNELLWRELYLSQILDDPRTCLSLLGHRLPEIGWRHQVKRIIRARTVVRNPGLCRIEERCAVMQTLLDVAVNTKPRREVSSGDLSYNHVWLVTLLRTGIWFDQHWDLDYEGRQTRARFHTYFGLTTNDYTPDRLLETRSIVYAMRNYREANEWGPFDKHGSGMVNWEHILAIHHVMSMHIVPTRPAVGFMTFPMSLPFCQSVLPPGLHLDETLDWVGIEGLWECSFAFCDHGQLLAFNNDDRSDNLPLDSEVFQDATFQEIFSTISIRLRVTSTIPDPAHPNRPMIHFVGGIEDQSHMHGWVKLTPDHQIRWHFESGQLGNYIWRLVNSIIYLFDMFSHWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGK1</accession>
    <name>A0A2R6NGK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGK1"/>
    <dbReference type="STRING" id="98765.A0A2R6NGK1"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="601" mass="65239" checksum="235FF1BDB5229B0F" modified="2018-06-20" version="1">MARHSLAYPSVPASAPTSPAIVRGKAYPPATPQRVVHRGQQRLSSPPYTPVTAHSTPYTPLSLRSFSSSAASSLATPVSATSNRRLSFSYSPEDSLRGKSKKGAADTTNNWRTRANENGIRVSAGEESQYADDEADDCSELDASRYLNMDKSLLPAPFLSAQRRARALTHIQPQVCAPLQQISDPSQLSTPARASHSQPQPFTFSPAFLNTPPPKPSILNKYRLRGTVTDPAHTRRRPAFEQASELFDINEDEYIPYPPAFSSTPPVAAHLFSQTLPLNLNDPFDLSSVSDDIYYDAQSLCVYDDEPEPPSNAPFCSVCGTSSGSLAVLEPCTHPLCSACLTSALNIVGEKDMECAVCKAKVDDFKIKKPTANCAASFNTQTRSTTNHGNNGDAYSHPFGLMPSVIDDGFQDFIDRAQGASTPIASAHSLPKSKSADSSVLRIDNVPWDITPPAIAAWLRHPVERVHVLLDRKGKTQSHAYAEMVSPDAAKAALRTSQNSVLGKGKRARGVTVTRSNQEELMRAVSRSAEHLRVITLMFSAPQLFPSWKGTFDGARPSLANLDNEHVIATLQHGLISDSELKAGRTSSDDPHRRQSLLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH25</accession>
    <name>A0A2R6NH25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH25"/>
    <dbReference type="STRING" id="98765.A0A2R6NH25"/>
    <dbReference type="OrthoDB" id="5594057at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02509">
        <property type="entry name" value="GDP-M1P_Guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049577">
        <property type="entry name" value="GMPP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054566">
        <property type="entry name" value="ManC/GMP-like_b-helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22640">
        <property type="entry name" value="ManC_GMP_beta-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159283">
        <property type="entry name" value="Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="3">
        <location>
            <begin position="125"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP isomerase/GMP-like beta-helix" evidence="4">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="485" mass="52412" checksum="85035F91374C9B69" modified="2018-06-20" version="1">MSQSILGQANGPSIEFMFKQILESVHKSQLEIAELRSETHELRQANASLERQVKEGLNNGSRIHTGFNTPAPSSPQLRAKSPFLTPSSIPSLAVPPSIYVPSPLSDHALTAFPFGTREIPGFYVVIPAGGAGTRLWPLSREGHPKFLLDLTLKGRSLIQATWDRLLPLTSAARTAIVAGPAHVKSIHEQLPDLLPHNLLCEPSAKDSMAAIGLAAAVLSHRDENAIIGSFAADHMISGDDAFLAAVAEAVEVAKQDYLVTIGIAPSHPSTGFGYVRLGEKLNQPNAPNARLVSSFKEKPDARTAAAYIKTGNYRWNAGMFVTKATFLMDLLKEYKPELHDGLQKIAAAWDDENLRQKALNEIWPDLEKIAIDNAVAEPAALDRRVAVVPATFGWDDVGDFSSLADLLPAEANQPRVLGDSNLVLTEQVAGGIVVPGSGRLVSLLGVDDLVIVDMPDTLLVTTRARSQEVKRLVKKCKEQGWGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH39</accession>
    <name>A0A2R6NH39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH39"/>
    <dbReference type="STRING" id="98765.A0A2R6NH39"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="346" mass="39600" checksum="A29BE89AD43807CC" modified="2018-06-20" version="1">MPYIFQRHPRYVVVFAVFVICSFIYLTTPSSPNVDPSSFVGLPGDPALPSRVQHAERAYQKVVEKRQELIKKHGPTPSQVVMFPPDQNPWPAYTVWDFFPAAFNCPHELERIGSLGDGGKWTCGVSRIAEKPDCIIYSFGTDWESAWEASVLENTEHCEIWGYDHQTKSFGRQVSHASFSNKHRTHFTSHVQLGPIDKHASGDDPKLYKLDTLMNKNGHTFIDILKVDIEGYEFDTLKAIVRPYIQNGEPLPFGQLQIELHVWSKKFSDFLTWWEMLEAAGLRPVMMEPNLVYVNYNRQSGAELAEYTFLNIKGDNIFTSDAVRAYVPSEDTDEPKVQFIRHGPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHB7</accession>
    <name>A0A2R6NHB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HECT-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001244">
        <property type="protein sequence ID" value="PSR71760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHB7"/>
    <dbReference type="STRING" id="98765.A0A2R6NHB7"/>
    <dbReference type="OrthoDB" id="2794110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF908" evidence="2">
        <location>
            <begin position="82"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DUF913" evidence="3">
        <location>
            <begin position="454"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118248" checksum="7863157B174FEB08" modified="2018-06-20" version="1">MKIVQKRRALPPPQVAELIEKLAETSVEDLPDFLSQIDSWKWPRSDLNAWIKVLNKFDTILEEIIRDHDIDNLQINPFTSSTKRLLSEVLRFERLLLENSTNRKSFNSYDRLNSLMATSDIDILICALNVLLRPAQQYSAQPSVSHALSISTPRLTSLAKRWPNLHDFDVKLAALAEESGKTQVDSLPDEAREAVFTFYRKDGQTSSVKGKEKVADTEVFDAPPQTPRKGSTSGPPAASAPSGSVTIHIDSATLESKSATDILADAIETYNIPDEEKFELLCRIRTAQALTKVHSADREKLVIVRLLAIAIFCHTHSEQTAFASLFLYEPDLVIHIAELLRLDRGIDVQVQTAALVALDAIARYRSKLQDVLTAVNAGVNHGILMALLRKTIGELANSESMISQPFVETLFSFVTYMATHAAGGNMVVGAGLVPLLIQVLEIHLPSRLYAVPKTTQLLDNVLYGYTNAFQLFCNARGVDVLVERIEHEVDVDLAEYGGDKAASDVAVPHGKIPVSRVAVLKHIMRSMHRMMQSSGTSEGLRGLLDSSLLKSIKKIMENGDVFGPGILSIAINIMATFIHNEPTCLGVIQEAGLPDTFYKVVESGLEPAIEVIQAIPNAIGALCLNPVGQEQLAARPTIIPALLSIFTSDSHQRILQEKEHSALVGSAIEELIRHHPSLKDTVFDAIKATMIKIEELGNSFTVPDDIKPFYVLQPVKPSSTPSRPDPDVEMAPNEPREAPAESPATNVVDNDTAKDYLEDDKSHDNVVISYIDVFCKFLEGIFQHVPHCRDFMSNTDGLERLGRFTALPCLPYDFAGSVSSDSLVQVVRTMVEASTSETLGFVVKLVNDSLAETKYLREGNQGESKLSALANTPEEDEAEANKSFRQMVTLHVRVMLLSDIYATVGYSQGRASATLIQALNGPEAGDLLLELGDLHRTSLWENIILKTKGSPQAPQFPATEGSPDPEPSSSSASSETLPGLPNAALANGAQDPPASPIIVLPQMDTTLSKDADPKECNIKALKHIATQLPNALAPFFQSIIRLFQNRRNQDAAQKQRILDAADVIAEVVLRHLSPRPAGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHB8</accession>
    <name>A0A2R6NHB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHB8"/>
    <dbReference type="STRING" id="98765.A0A2R6NHB8"/>
    <dbReference type="OrthoDB" id="3216045at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="692"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="758"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="924" mass="99223" checksum="CF36B49715FF7947" modified="2018-06-20" version="1">MGKELSDTKRPSGPSHIPVISSWPSPVHIPTSASGPYLGFTSPTGRLAVSDSPSHPSLSPPPASGGLSPFRSFRNLLSFGPSKGQSTSAVGPSRSSFAGLRRPTHGDRSVSTPNLRHKSQDDLPVLSIELFPSIELSHRVDEPLIDSMELHTRLGLQLPTPDSESPSSSRASSVHADDHPVALATTVGISDLSTILEAETSGMSKQFSSAENSRDMSYPPSPNTPGTADSRHLMAADLSDRSVARPSRGSNETSALDLSTSMVPTEVLAAMSGPDRADGWVHGVVLDGLAESPGEVTAADPNISFNLDALDPDLAALLSPYRMTPELASSPRLTLMSDIQRQPKREFSSKIGSPSSSVPSPSSQSSPRRSASLARPGIPRLASSTVSRLVRSASERPAAPTTEKDKSPSSSPIRRTPSPRIFEPIAERQSLQLPRRSPLATEIQLPRRPASGGRDAESSRPALSRLATPSRLPAAASSARGLSRHLNASASSPGWDVGDSVSSRSPSVAGSVISKRLSPHRPSFDSVPEERPRVRTRVRSSSLTESSPYHPAALRSTDWLGPRTAKAFAAAGLLDRDRNPNGPNSRPGSRFGTTRSERDTRSHYAPSRMGFSEAGSGSSWERRSGSVSHTAMSDLASPPRTVFSAVSTTPTSVSAASSAQKHLQSELQLLQDKHALETGALLNALADSQRTTRLLRDENTELRDKVQSLDDQLTDALNEVHRLQSMRPSIPQRGYFHRPAGRPFPDSTNRTLANSRFHSLSHSNSEFHNNSSTPDHDLQSDCPPTHEHISISLPPTTTESYTDPQSKRYSTSSSVFPALPNNMTMLLDETGVDDRPSQMQHAPPAPPPYLPDDITVKYSLGSYHRRTASSTGNISPTTANFSMITGSPGSLDLRPEHDRLLSDMPTLNLCEEDYELDAFNDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHS3</accession>
    <name>A0A2R6NHS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHS3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="7785" checksum="54CA43CC1A4D3E6E" modified="2018-06-20" version="1">MVRKNDSESSMIGGVYSVRRYYDIISARTSEIPDACTPIVSLKFENLPSGLRCLETEKSVAGIPGMSSPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHT1</accession>
    <name>A0A2R6NHT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PLP-dependent transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHT1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHT1"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="53841" checksum="20C809674056C562" modified="2018-06-20" version="1">MAPALLETEAAEGFATKAPLKPTAILHRTPWKPLVATSAEGSYVTLEDGRTLLDAVGGAAVACIGNGHPEVVQAIKAQVDKVSYVYNMQLSNEPAEELARLLVNSGGGGFELCGFVSGGSEAMEGVIKLGRQYYYETKQPQRKNFIARQLSFHGNTLGTLSLAFHKARRAPYETILDHENFHHVSPAYAKRFKKPEETEEQYVERLRQELEDKFLELGPDTVIGFVAETVVGATTGVVPPPKGYFKAMKSVCEKYGALFILDEVMSGMGRLGTLHAWEQFGDNICPDIQAVAKGLGGGYASIGAILMSKKVADGIRDSAGFWKHGHTYQVCHQLIQTALVHPLIATQQAHPLACAASLAVQKVIANENLLANARTQGAYLSSLLHERLLSPNCIAAPYIFDIRGAGCWWGIEFDFESPSAPKVGFKGKSFAVLVQQRALDKDLIIMGMTGTAALDGSKGDAILLSPAYNITKEQIDRIVDGFLETVEEVLRESFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHZ0</accession>
    <name>A0A2R6NHZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHZ0"/>
    <dbReference type="OrthoDB" id="2838513at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10781" checksum="1AF6E0BD632F08E7" modified="2018-06-20" version="1">MKTDSHQDHPVNSSSALTNSQDGDSFELYDLRVEVICPPGARILCGAKEGDHFTLEGEMLYLPPGQGFSIYSLDWDANFLVRIYTPAVGRKAAGYISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIA6</accession>
    <name>A0A2R6NIA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001224">
        <property type="protein sequence ID" value="PSR72031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIA6"/>
    <dbReference type="STRING" id="98765.A0A2R6NIA6"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005825">
        <property type="term" value="C:half bridge of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000301">
        <property type="entry name" value="EF-hand calcium-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="209" mass="23891" checksum="0644B54780596AF0" modified="2018-06-20" version="1">MAGKLRPSSEVRTHANASVVFHTATATDHLSISPLIVSENSQKIMYGSSAAQKAKRRTHTRPELTDEQKQEIKEAFELFDTDKDGCVDYHELKVAMRALGFDLKKAEVLKILRDHDKTGHGLMDFDDFAKIMSERILARDPMEEIRRAFQLFDDDNTGKISIRNLRRVAKEIGDRLEDDELQAMIDEFDLDQDGEINEQEFFAIMTDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIG7</accession>
    <name>A0A2R6NIG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001208">
        <property type="protein sequence ID" value="PSR72184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIG7"/>
    <dbReference type="STRING" id="98765.A0A2R6NIG7"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="413" mass="44425" checksum="29EBC09B4E7E1DD1" modified="2018-06-20" version="1">MSDLTRFQNVPAQDVPYFTPAQIPASGTAVPDPDGKPIPSLFQPIKIRGLELQNRIVVCLSSSVPGIRGALIKPRLFGGIVSRGPGLSFIEATAIAPESRSTSEDLGIWSDEHIPAFAELTTFAHSQNQKIAIQLVHGGRKASTLPLWLPQTTFATKELGGWPDDVVGPSAIAYSDDSIVPKELTKEGIQGVVQAFADAARRSVQAGFDVVEIHGAHGFLLHSFMSPVSNHRTDEYGGSWENRTRIILEVVDAIRKVVPADMPVFYRISATDFLETSMPDSESWKVSDTIKLASLLAGHGVDLLDVSSAGNHPLQTLGPLRTVEAFQSDLSAEIKAAVGDKIIVGAVGGITHGKLAQRVLDEGKADVIFVGRQFQKNPGAVWQFAEDLGVRITVAHQIEWAFFGRGVGRAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NII1</accession>
    <name>A0A2R6NII1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001208">
        <property type="protein sequence ID" value="PSR72186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NII1"/>
    <dbReference type="STRING" id="98765.A0A2R6NII1"/>
    <dbReference type="OrthoDB" id="3197626at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="25264" checksum="5A660E458C09FCD9" modified="2018-06-20" version="1">MALWSQSLYIVVPLVLIILGHWSLILQGVLLKAAWVPGAGCVITKTNNTVLAATFIYSMCFDLVVLVLTAAKLAFNGDRRSQLMGLLFKDGLIYFVIAFVANLLATVFMLLNLNAIMSVIFNVPAAVASTIVACRAVRRLSDWSSNGPEVFSSRPTNHSGGAIAFRTNAANSRHGASVSVPHGRKVSDGVHVQMDTFTVEETDRESECIAQKGYEMNLEDPEISADFKRPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ73</accession>
    <name>A0A2R6NJ73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ73"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ73"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="317" mass="35401" checksum="A2C23575246A09D5" modified="2018-06-20" version="1">MSSDQKLNVLMCGTGEYTTGWTPSGASKSDKKVEKLSMVGTNGGKFPAIREHLTANIAQVYKDMDTSFEAFPQGEKFDAEAYKEAIDKLSPGDAAIIFTPDSTHYPIAKYAIERGLHVLVTKPAVQLLQHHLDLVELARKHNVICFVEHHKRFDPVYSDAKVRAQALGECNFFSAWMSQPKSQLETFRAWAGKDSDISYYLSSHHIDIHCWIMQGNAIPTRVVASAATGIATSEPYNCVPQTEDTITLLVDWQSLKSSKHRSTAVYTASWTAPMKAGVHSAQHWYYMAEKGEVNVDQAHRGYDIVLDDTGKTYYNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJN3</accession>
    <name>A0A2R6NJN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJN3"/>
    <dbReference type="STRING" id="98765.A0A2R6NJN3"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33439" checksum="0303AFBF241436C2" modified="2018-06-20" version="1">MSLHPRVWFITGASSGFGRCMTELVLKNGEIVVATLRKPETIDDLKVQYSPDRLLILKLDVTKPDEIAASFATAKQTFGRIDVVFNNAGYTVLGEVESVPDDVARAMFDVNFWGAAHVSQEAIKAFRDTNQPRGGRLLNVSSMVGIKALPALGFYSAAKHGASLCLLDVQGSHWVLALAALEGMSEGLAGDLDPEWNIRVTILELGGYRTKAGTESMVRTKQHSAYNKPALAPSVIRAYVANPGRGRNGSQDPNKASIKIFDLSLLQDPPLRLVLGKDAVAAGKAKVASFSSEIEKYEEWSENLYSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJN6</accession>
    <name>A0A2R6NJN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v11621</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001160">
        <property type="protein sequence ID" value="PSR72521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NJN6"/>
    <dbReference type="OrthoDB" id="3363652at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1307"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR72521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1328" mass="148533" checksum="37A235D05299A85C" modified="2018-06-20" version="1">MKGSMEDHGHLGEQNSVGTHMYTDCDSNTHIFDLYSVGPGPTNSDEQGRGDNTTQPFLNHIAFHGPQGEIVRVKALIDDGAMVNAMCVNVWNLVQHRLGEISPSKKRLRMANGTIIPSEGRWQGTIEWGEIRVQGVFEIFPSGGNWSFLFGKPLLHAFRAIHDYDDDSITLRDCTGRRSRMKNQVERAINNATLTAAGLSLLVDIKLTQPYPQPVPPPNVEPVWHIELQAPDGIDTIEEPGVEIPDLFEEHTNNQNIYTRHTEPWKPARVAAILQAITIGPDLTIEERNQVKSLVAEYADCFALSVSEVTAVPDAIHRLNIPEGASFNRKIHQRPLTPPQRTYLNKKVDEMLAAGVIEQCKPDQVKCVSPTTLAQKAHEGGGLTLDELRTKVNEQCTAAGLQLPYPNTPNRHTEVSKQTRNTPKWRICQNFSQVNKLTEVAPMPQGDIRLKQQNLSGHRWVSTFDFASGFYAVTMAEESRPYTCFYVEGRGYFWYLKMPFGLTGAPSTFAHLTAAHLHDLITDGTMELFVDDGGTGGSEFSAKLSNIRRILTRVREKRLSLSAAKLQLFMTTLVFGGASVGPNGVTTDAAKLTAIVDWEKPSNALQLSSFLGVTGHFRDLIRGYSKIEGPLRDILKAATPPKNSGKSAYRRALASYSLGDTRWGKRQTDAFIALKVALTSEPVLRRPVWDGTPFIITSDGCKDGFGAVLTQRSQTVLPNGRTVDKLHPIAFASKRTSRSEEKYKPFLLELAALKFALDKFSDIVWGFPIEIETDCSALRYVITNDKLNDTHSRWRDSVLAHQIIDVRHIPGRTNVADGFSREGEGHHHKPGDGSDWTVQEDWEHREGLDNDILLVENAPANRQLLQRFEQEPLFLDVIKSLQDIEDSNIDERTRQRAKHRASQYMIEDGRLWKVRGGTKGRPRARVECRTQHEAKELAAMEHATGGHWGRDAVKLALLDRICSPKLDQSIMDAISECGKCKNFGSTHLHSLLDPITRRKPFELIVGDYLSMPTGKGGFTNLGVFLDTFSQHVWVFKHKTAGTSKTTIDSLTAISRHFTPPETFMSDGGKHFDSKEVREFCLAQGTKPHIVSAYSPWVNGLVEGTNKLLLHILKRLCAPDLGEDECNELAHKHLPKNWTEHLDAAVHALNNRVLSALQHTPKELLLGLPIERRPTPLEQATSAPTADDADVHFLYAEQQRLDGYNAAVHHATKRKDAFDKRVVRSRAGDVTFANGSLVQIYRNDLDNTHRTERKILPKWSEPRRITGCTGNSYTVETLDGSPINAHFHARRLRAFQPRMGTMLALNESRRSHAHTQPPDRVDILAPEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJV3</accession>
    <name>A0A2R6NJV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJV3"/>
    <dbReference type="STRING" id="98765.A0A2R6NJV3"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12193">
        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="544" mass="60199" checksum="3BBDFBAA9B30E690" modified="2018-06-20" version="1">MSLTMRSDFSHRYYESNAIASSSKARCMSPSPLPDSSCVKFEVRTPVMPVYDDISHTCGVFESTADTHSKFAMNRRLIQSSPPFRHSRPLTLQPTTFHLNPNSVNLYSRSQPIQQNHRYDVLPLLNPSLTNDFSETAGHHGISRPELYLPPCTPSSQYDSLNTSSHPVFTNPSALAAHHGIPQSLPPVPRTTRYQPEKPAVASSSTSPNNDFDFPSLCSNYLNMLSQKNEDSNPAVANTASSGNQPDDDAVKALMEVLQGTFAAPLKSLTFSDASQPASPEFQAFEEFTNDVFLTSPFEDSPWEDSLTTPAMESVDMSSDLLTSPAIVSGDDFGYGGVSLFGFSERAYEPIKTSTSAHVVHHPTSFDGMYTISPGTPALDSSSFHPSPSATPLETPVDSQSRAPQRRKSAPTGTRKNITPEALVPYDAPIQTRKYVTPSSTSRKEVPAIFAKKRARSQAFGKDDDDELEDDDNLNPTDLDAIEAKRRQNTLAARRSRKRKLEYQRELELSVEKEKEDKEAWRHKALFYEALLKSHGHEVPSFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKB5</accession>
    <name>A0A2R6NKB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v11300</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NKB5"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="19">
        <location>
            <begin position="86"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="20">
        <location>
            <begin position="199"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="21">
        <location>
            <begin position="786"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="18">
        <location>
            <begin position="1116"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSR72803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1586" mass="176913" checksum="49E1E31CD05B75A9" modified="2018-06-20" version="1">MAAKKKLSQTVKIPKTIVTDGHPQNSPSVPQTPKTPADEGLDFFESAFKQGDAPIHVYELELDPDGGPNKDRSYMRLPPAYVPYILRVALEAGTPASKNGVFKTNFPLDGGYFSRDHFAERKLPTDFSKPIHIDLPISHAGAFCYWIEYDGDAPGTRVKGREGYFNIDPILRPKARSSIIAPGAKVDQQGGAVLSDYVNLPMDGLSILTLVSKWMGTINEWREHLAEASERGYNMIHWTPLQERGESSSPYSIRNQMVYEPAMFESKADLGKDGGKTKMEEVLKMAKEEYGLLNLTDVVLNHTANDSPWLRDHPEAGYSPSNTPHLTPALELDTAQIEFSASLEAKGLPTVVSSMEDIDTLMAAFKDYIKGKNFWHYYVLDVKAERESVKKALSQNKLSSWSGIEHKNVVELAEVLKSSGSVIGLGVPQKRFGTHVESSVAAGLVKAAFVDLQDVDALADAWIRVVDVLNVPLYQEWEDDTEAAISNIKGRLKYTRLDEHGPKLGPITKDTPLAESYFTRIEGKAEEDPGKYSVANNGWIWNADPLKNFALPPSKAYLRREVLVWGDCVKLRYGDGPESNPWLWQHMTDYVASLASSFEGFRIDNCHSTPLHVGVTLLDAARVVRPDLYVCAELFTGSEEMDTLFVSKLGINSLIREAGNAFDPKELSRLLYRHGLGKPIGSMDSACLSSKEELPPPTGKGPTRPCIVIPHNGSVPHALFYDLTHDNESYLDKRSAEDVLSTGALMTFSYSAVGSVKGFDDLYPKLLNLVQEKRKYEITRLGENSGIAKVKRLLNALHTEMALGGFEEGHVHQENDYIVMHRIQPATQKGYILIAHTAFQKGSKDRGFINPVKLRQTKAKFVYGAHIEFSSYDGLSDEQTIRGMHAQVSDMKPVVVPQGLDGEGPYAEVIVPEHFPPGSIMVFETQLQGLESTLDTFCSSGAEEAFGDLNLVELNVVLHRAEGEERDATKGEFGAYNVSGMGPLVYCGLEGFMHPLRHIMRYNDLGHPLCGHLRDGCWAMDYTSSRLEKQTETFSNLAKPAQWYKERFERIRENVPAFLRPKYFAIVISEAYKAARKAVIEQSSEFIASGHSFTHDLALCSVQMHGMVHSASLDPVKQTPSLAAGLPHFAAGWARCWGRDVFISLRGLFLTTGNFVGAKKHILAFASTLKHGLIPNLLDSVRSPRYNSRDSPWWMLQNIQDYTASAPDGLAILSEPVKRRFPKDAEWVPWDDPKAYSYSSSIAEIIQEILQSHADGISFREYNAGPNLDMQMKDEGFNISIQVDWTTGLIFGGNSNNCGTWMDKMGESVKAGTKGVPGTPRDGAPVEITGLLKSTLRWLAQLSDAKKFPFKGVEATIDGKRRLVTYKEWSDLIQTSFEKCYYVPLDPSEDPNYNVDTNIINRRGIYKDVYGSGSGREWSDYQFRSNFPVAMTVAPELFDERHALYSLQLADKVLRGPLGMKTLDPADMQYRPYYDNANDGGDPAIAKGLNYHNGPEWGWPLGYFLRAYLYFDTRIGAGKDDPTKTLHHLHRVLLTPRHHIKNDPWRGIPELTNKDGEYCRDSCNTQAWSSSTLLDFLEEVHKMSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKH9</accession>
    <name>A0A2R6NKH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001160">
        <property type="protein sequence ID" value="PSR72522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKH9"/>
    <dbReference type="STRING" id="98765.A0A2R6NKH9"/>
    <dbReference type="OrthoDB" id="2730579at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="67955" checksum="0323465AFEBC393B" modified="2018-06-20" version="1">MSKRPCIYNECRHEKTVRNLGELSAPPVSAGKTCERWHPCRWPTAGAGAPAESASIVTEGNSTARKQKPRVYKRDPQGKFTSNATTPDNAAHRDGDHDEDLEEVEALLQSSTLSLPPSSDSPASSSAPSPTSSPIQSPHWHQHLRLTSQTPPTSPAAIPAEPTPAPTQRQRSAVAMTALVPLTKFGGDDPAEDAHTFMLGLEANLDDTLSDKRKAVILEALLTPNSSAVTWFDDVPDATKSKWDDLKAAFKLQWPKKLAPGISVTEAIDTLKSRPLSGSRLGTYEKVHNQDVPAHTVWGRLIVADAKKWKVPGIIANDIRANLPEALRSMLSAVITEWDDFLKELEGVSVPALKEKVQERNLHEQRMADIERRLGKSHIAEPRDASYTPAPYIQRFPVVNRQMPGTGEQINRGPPMRRAVTPYAYNNAPTYAGPPGYNTHARPTQQPPPRPPFRSLPPPNIRLQRLLETTARLPHHPDTPEGRQAYQKQCVEWASANNNLEPREDNPYPLTPGTLALGTRECYRCGRGEHPASTCTAESLPPRESSWRAVAGYIFKLAARMDRNTASIMYMSDYNPFYQHTYEQAAYHDPSPAYGYSQYQQEHGHYDPQSGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKK0</accession>
    <name>A0A2R6NKK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKK0"/>
    <dbReference type="STRING" id="98765.A0A2R6NKK0"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1350">
        <property type="entry name" value="Pneumovirus matrix protein 2 (M2), zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="164" mass="17729" checksum="5D40DDE398A97E92" modified="2018-06-20" version="1">MSPPSGSPPLCVFYLQNACSRGDQCRYSHGPPQSEDHKTASPSPSVLCQFFSEGSCRFGGQCRFYHPADSPNDNVAEVTSWRKPNTSTNNRTGRLLNIGSKNTNPIVSPVMKRSAFGPCKFFSQGRCMKGEACSFTHSALAGHPATPLPLPPDLPAMVRALQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKS1</accession>
    <name>A0A2R6NKS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v11585</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKS1"/>
    <dbReference type="STRING" id="98765.A0A2R6NKS1"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="27"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR72592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="441" mass="48618" checksum="4544F408028BDA09" modified="2018-06-20" version="1">MTGLEYTKPATKLEGYEFFRKVLGSPKYVVAPMVDQSELLFMEGVRKPYRDKNFNIGKGEEGGPGDRPLIVQFCANDPETLLAAAKIVEPHCDAVDINLGCPQEIARKGHYGSFLQDEWEVIYNLIHILHKNLSIPVTAKFRVFSTVEKTIEYAKMLESAGAQILTCHGRTREQRGQMAGLADWEKIRAVKEAVAVPVIANGNVLFHTDIETCLAATGADAVMSAEGNLYNPAIFCPSSIASTSSTPTPAPSTWMMPFDTGLHVPHTTLALEYLSIVKSLATPTSPSAVKGHLFKLMRPALGREKDLREKMGKVKVVKGKETEGWEKYEEVVLELQERMLRDATAAESCTADELVTIDPSTGLKILPHWLAQPYFRPETAQKLAQVRVNDKKTEIAAEELQNGEVDPVDDSIIVGKRAASERTPEPDELAKRVKLTADLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKY4</accession>
    <name>A0A2R6NKY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001122">
        <property type="protein sequence ID" value="PSR72971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKY4"/>
    <dbReference type="STRING" id="98765.A0A2R6NKY4"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="39495" checksum="ED32A31156C7D0FB" modified="2018-06-20" version="1">MDSPNADSTVLRNDMASTRDVRLRALQKELSDHLKDHNSSDARSSWKERHDALATEVATQRQRKSLQREASKRRDLTELLRLHTKSIATKRRTERLSDTSKGNLDIEVEYIQDEEGKRMDERKREEKRKREEERKQEEERKREEERKREEERKREEERKREEERKREEERKREEEEKEKERKRHDGIKQQYEDAYREFVQAREDCSLPDHGLRAFFRLYDAKWDVLKNPIELQPLAFAELPWPILSEHLLSPSEITMERVQQFIFHPTRHKDMTKVLIIREELLRWHPDKFESLILPKVRECDKQLVAEASGLIIRALYGLKSLGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLI8</accession>
    <name>A0A2R6NLI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLI8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="516" mass="56041" checksum="42D24C70BC1E67D4" modified="2018-06-20" version="1">MILLAPRKANASKSLLKPDLLVIGVQRDSDYSVRITPTGSVLVRGTSSVSMRTLDSVSATDIFYKYLPESTRYLDCSRDTDFTPVVSRASQDMEFPAALSLIPLSVHGDMTICTEITLRYQDLCRILPELSGSDAVLVNTAAPSFLPLPSHMEDDIVLNVGLAGSQFLLAPLHVLAPPEDESPWKLALLSPYVSALVETVVEIGNASPSLPTPPPSPPLRATPIVSSSSAATSSPQAAYTPSISLPSLQSVGEFFQENQNPEYAPLTPSSPPATLHEALSVEQPVETKEPENRTSTISRRQPPQGGFFRLLFSWLFRAIFARVCGFIDLGFRWWGFPSMLPHIMLASEGKRNLIQEMRTEEMEKVEEPVNESVEEDIQADVSIQTTTSVSESTLADDSFLSVKEEETNSVHMFEDALSETTIEILKPIADVAPAITELHMPVSKPRFLADVRSNMVSFLVRTPHSRVSPSDLAIAVDGKPVDGTHPGYSCAALSGNIYLLGLHGPADGSKLEITLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM42</accession>
    <name>A0A2R6NM42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v10734</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM42"/>
    <dbReference type="STRING" id="98765.A0A2R6NM42"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
        <property type="entry name" value="SNARE complex subunit SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Longin" evidence="15">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="16">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR73442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="19182" checksum="28DC100B3D6AE1E3" modified="2018-06-20" version="1">MVRSTIVVRASDALPLAATVDDEQTEQALQEHKQQAKLVFRRITPNTEPRCSIESGQYTLHYLIADNVVYLVIADKSYPRKLAFSYLDELSKEFTTSYGAKVEAVRKPYAFVGFDTFMGKTTRLYQDTRSAGAGGSNNLDKLNDELQDVTRIMTKNMEELLWRGDSLDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NME2</accession>
    <name>A0A2R6NME2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NME2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="6131" checksum="8218A67BFDD8EC09" modified="2018-06-20" version="1">MHGFAGLPCVRYAVTASGRVPPSIANRPWWKNFDSDIMYDGRQQEVQIKRIGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMG1</accession>
    <name>A0A2R6NMG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMG1"/>
    <dbReference type="STRING" id="98765.A0A2R6NMG1"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="20394" checksum="84C7368C4A914E66" modified="2018-06-20" version="1">MCTSLFLMILKAQCDKIKRKALLAPNSMGQENNPALGGLNRGARSFEEQSNRMRAGGGLMGLGGVGVDVGAVVGGMEANGIQRTPISSRIVPQGTTWRPPHTVHGVQARHSNPQRQPFSTMTDHSFRTSTTRSDQSDSANEVENLVGNHAMQRANIGPNNGWMPQAPPGRSNRAQPSNKRAGGGFRPAGTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMP8</accession>
    <name>A0A2R6NMP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GINS subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMP8"/>
    <dbReference type="STRING" id="98765.A0A2R6NMP8"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="4">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="115" mass="12534" checksum="AB9AD25AA434DE19" modified="2018-06-20" version="1">MPPPFTSRVRNALNAEARSVKLSNLVGQGGLWYGFGRMIMNLLDDSGADDMSNMLVKTFRARLPEAIDQAQHFASINVSGSSGGTGDATMAFREGLDGTERERKYYLALQFAPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNR0</accession>
    <name>A0A2R6NNR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001029">
        <property type="protein sequence ID" value="PSR74044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNR0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="411" mass="43032" checksum="00F99D53DEBF0CD5" modified="2018-06-20" version="1">MTAAKSAVLDFADSLKIPMVVHPRGPSVTSENINTPFEPASQVRRDNFPELGRPLLSSVTSSTFEPNFINLSASPGTGTLASSSLSPPPLAPPLFATVISSSTPVFVPTSDVSISTLNPFIPHGPLETISITTPYNVPAGAITLGPFTRALTATLLSLSSTSFTPTTTSFTPPPSPWATSIGSLPVASAVDAGNPRPSGSRSTDATLVVALPGSLGAVAAILEGYGLHGTCGENAYEECVWLSVLTSTASPEGTRFPKLFGGCWGSGQLRKKMTAPISAPSEDTMNHEHAVQQSGEMIRRAYLDVESGIQSEYEKAEDTSAMSRHASSARACYGGPPPVPSLPSSMALTSDLSVSRRRQAEDGGVRIAGGRPGADDQADTGSHRTIMAWEYLQRDSARVELPFDFTNIQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNY2</accession>
    <name>A0A2R6NNY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNY2"/>
    <dbReference type="STRING" id="98765.A0A2R6NNY2"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015319682" description="Glycosyltransferase family 15 protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="46131" checksum="1A0903D2871D0D17" modified="2018-06-20" version="1">MMTPMRYILLVLGIIISLHFILSFSHEDYGRATSLSSIKSQIAGSKGYPPYKDGIPEEYYQSNGTIPSPQGRKANATFVLLARNSDLNGIAMSMKQMEDRFNKKFQYPYVFLNEEPFSEEFKSRVSELTDAPIQFGLIPHDHWYQPDWVDEEKASAARADMVRNQVIYGGIAICADTTQGSFTAMSFCKTTSITGGLSTHYHIYFKGDRITYFALRRRPDVTFFCDLDYDPFLIMEDQKKVYGFTVSLYEYPATIPTLWETVREFIDANPDLVEEGNAMNFISDDGGNNYNRCHFWSNFEIGDLDFWRDVPYTKFFEFLDSKGGFYYERWGDAPVHSIGAALFAKKEQIHFFSDIGYRHNPFQHCPQGDAHKKGKCWCNPNDNFDYEGYSCLNRYDKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP21</accession>
    <name>A0A2R6NP21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001013">
        <property type="protein sequence ID" value="PSR74201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP21"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="35071" checksum="849DBACDA085B173" modified="2018-06-20" version="1">MSITNDEEQAQLESITAFFLTAPTPFLDNTATSLWILHIAHMISEYGLLDPNLQSKTIQNILRLLHAMVLPYANNSRFTAATRHIPAPAKSIHAYFPIHDGSGDEDTSDSSQNTDSVSDNTGHVDTPAQTTASCSTSTPSTASLSAPGTHGKSQDRTPAQHHRVKRALCINSESTHGTRCDPNDSSLDNDDPAPPPQKRPMLTHAPGRHISAPLTVTNVETTKECTSCIPLVNYQTPLLPPLLLHIPSTTGQVGCSNRPQGTLPTSAQRPSHADLHQLALAEQIIRDLHVKRELMGDLGLYIQCLESMKRTLDEYQCDLILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP73</accession>
    <name>A0A2R6NP73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001007">
        <property type="protein sequence ID" value="PSR74273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP73"/>
    <dbReference type="OrthoDB" id="5374756at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="32790" checksum="F4DB1CEB83507550" modified="2018-06-20" version="1">MHILHYLVAFAFITRVCGGVISFEPKEEDHSLDIAARDSSSSTVETVELPSNSLALRSSDSSLATVSWTFSGNKVLNFGVFIVNSFVVGAVCAASGAISCGIAAAYAVFTSFFAKWIFTGRSDNFDVNDLGADSEMYLTLPPTPAKTHIQRLSTELEAGTWHTIGHMRVGIFNHSLHYYNHGSNIHTLRAWQRNFVLNGTEGSDKRAENDNDGTVVDYSWQSTNEQSYDDFGSSSASTSYFAANAMGYMIDTAQGIAACADFADQDGDMDEAVLTIGWNDQPFDWDEPGEFESALSHCNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPJ1</accession>
    <name>A0A2R6NPJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NPJ1"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="337" mass="37040" checksum="8E0026CDEAD3D761" modified="2018-06-20" version="1">MSLPTRKIGNTDVAAIGFGTMGLSTAYPPIGTLEERLDFLDALYNSGCTNWDTADVYGDCEDLLGAWFKRSNGKRSEIFLATKFGLVFKENRNRVVDGSAEHVRAAFDKSLRRLGVDSVDLYYLHRPDPIVPIEVTVGAMAELVKAGKVKYLGLSECSAQTLRRAHAVHPISALQVEYSPFVLDIEDEKIGLIKVARELGVTIVAYSPLGRGLLTGNYKSPDDFPEGDFRRTIPRFSTENFPNILKVVEGLKTIGDRHGATSGQIALAWLLAQGDDVIPIPGTKKVKYLAENLDAFKVKLTKEEIDGIRDIAQNADLPGERYPSYLMSVLFGDTPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPY6</accession>
    <name>A0A2R6NPY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPY6"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="279"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="842" mass="96116" checksum="D28566C869CFE4FC" modified="2018-06-20" version="1">MAPRSERAAHIETEDTKGTIHPYIPEDVDSATRVPLTVWVEAVLGLPQERFLDWVRHITENEWCKDEIIYKNLIMFSNTHAEEDRHQPFGRIASRILELGREGLPGTDTCPIDEIRIVKNSPKYLKCIPEHIGHGAKRTPDMLVVRRSRYEHLRKIKARAFDWSDVLTFIELKMWNTFLHKKFRAWRAERGLPELDRKTLLPVVPSKDTSAVSSRTRRATAATAAKRLYRRNSDSDSLYEYTHVSDFDSDNSDDAYMLRSNPRVLSADPKLQAGAYALETVACTYGTRLFTTGIVMQDDKTSLWYYDACSVVRTDESLSLFYNFEEFAAVLVAFACCEPSQWGCLPPNIIKPPLSAPYPENFPPRNLKDYTLDMVLPEDGSKVCVTLQDPIFTQYSLVGRRTFLYTIKTNSSKFNKPMVAKFSYQVATRQREQDFIEVASKAGVGHLPEVHMWADLWKMSEGVRSIFFKRCGPDHEYEDRVFRGIVYTQYFPLKDLFSKSCELIPTMAYQMLDCLHDLRYKAKILHCDISANNIMWEMQGDEVVFKLIDFDSAIFVDDDSKPIVMTARGKRGAGTLTFMAYEVAKGMANRDNPRCKPVIHFLRHDFESLLYLSVYCMHTMPEMSEEARQALYKETIYGLENRSLYGLASMRLLIWDSDWPMVLPSQCEMLRPWYQQFRDIFRAADFKINMKYRRDESNPFDEETVDGILTRDAIKGVLKGESVVDWAALVIVPVHQEASGSGISHEETIEEEATEQNREKKAAPTRRAPVKKATGTKDSTKGKKVASAKSTKRIASAKASQTAPTISNVKLAAGSKTRTFLAVATRRGPTTRSITKKTLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQZ4</accession>
    <name>A0A2R6NQZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQZ4"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="316" mass="35945" checksum="3D985A2F42C7EB7E" modified="2018-06-20" version="1">MAPLLDIDIRPGYGLGQFELGSSLWAVLDLLTHHQHYFPQVDVKFDPDSPVSPVILHLRPHFDLLFSGYHQRLHTICLKKLQDPHPPVLLQYKQTPLSSQQQALTRVGVSRAFGPTYAGEDLRYPGVWFSFEEDGRGDTSARKGGSPNPEEKTQEVKRVIVSQKSVNDAPNDEPNDVLSEVRECPVMRGDISKAIVKVHDGVTLHFYPSTVEPVRIRIGETTAQDLTCDLGPPMSIHYREDDRMTIHSKSTKENEEINTGCMTHLPGTPLFQRYKRCPWAIEGDPEDDEDDTPPRKWYYDRVRSSRGRNICCNKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRK2</accession>
    <name>A0A2R6NRK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRK2"/>
    <dbReference type="STRING" id="98765.A0A2R6NRK2"/>
    <dbReference type="OrthoDB" id="1602884at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="307" mass="32371" checksum="A51AA087D847BD66" modified="2018-06-20" version="1">MLAALTTDALVLIDPPTLKKAPTSIPTTCSFSSQPTACAWAPDHSCLFVSLGNTIEKYDLNGTLLDTIYSGPSPLTTLVSKDKGNTLILGAGTQVIVLETQTGKVPQSFKSHKLPVLALSLSNDSSLLASISVSTVHVHNLSLASHTVLRGLPSGEVTACAFHPHTRTRLLLGIGLQLAVYDTTRPSGPSKTIVIEKGAGQIVAIACSPFSKTLVAVAYSGGNVSLVDLEKDKGLFRTLSLHVPLTSLVFSPEGAALYAGTENGNVLTLDLRALDKPPKTISVSEDCQKVVYMAIQVRFQGLRARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRT9</accession>
    <name>A0A2R6NRT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NRT9"/>
    <dbReference type="OrthoDB" id="2507450at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015341754" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1154" mass="119411" checksum="C6C8EE861BAF6B61" modified="2018-06-20" version="1">MFSKSYLTFVALSVLAVSDQAFGRYQWLERDGRAVHLYPRRFGQEHPAVIDKLSAACPGQVCGTLSGQAITPLLAAQGECTQQDMADAIIDAAQQFDAATKANMIALAVEYRQAEKNTPPDFTTNPPTNRNSVFCQKAPKNAELNGLVQAQDPANDPNIFFDPAKQASVTKGSQADTSPFGTSGDASAASSAVVSSVSSAAASSSVVSSVVSSAAASSTAAASAATTSGQALVAISSSADPCVVTVTVTADSSAVTDSAAASATTVASITSAAAVATSTASSSAIGDFGSCSVPQIQFGVGFDNRKETSFEPVDQTSYNHGSAQAIGIITQFICDTLTNKCGADQTAKDTCATATTAANGQTAKTGAQADAFNAVFGISTNFAAVAEVDDQGRTVAAGTGSAATSSAQAATLVATSVAASTTADASSATSTAAASSGIGNFGKCSVPQIEFGTGFDGRKETSFEPVDKTSYNHGSAQNGDIITQFMCDTLVNTCGADQTAQATCATAKTAFDSETAKTGAQADAFNAVFGIKTNFAAVAAVDDQGNIIGGSTDGSAAAPAATSAAAASTVAASSANVATSTSSSAAASAATSVAAAASGTNLQTFTGALGGVTPPAVTGSGTSFQVEGNSSFNNLANALTRSCDVQHNQCANAANASGNKGDLTVTACGDQQTQLARLTGRTTELLLKPSKAEAGISENLLLSPTQAIYMESTTMEDSQASSLKEQYSDPSSSHSTTKRRSILDKELFIERLETLYEKELTDLHAFAQREGCPFEEVGDERRSSLSGIARLSSTSVMLQLIVTAAKDEVSKRVLRRRAQYLTVPETVSGILRSISEVFESLYSIAGLHSFFLIVNPNDQLDEGFLGGTLLGREFWRGHRGCGSTGARAFQAYCQKPSTQILLPPQAAPNALVTGPTVQSANPLVSKKGPASSVKAQVYATTHPGIRSSTYSLRDVFLINNASFGTHNRAASGVRNAEMKWTNHSKLDSYGIHVVGWPSDVPMQNPSSLSTAQNKLILDALIHGDLRFLPLDTNSSLNTTGISEQQSRPLNDDTDVFASAVDFFWTEDRPETFVSGSETLIPSVSAPVTRQDCLDFGRETSQNGSSWSVDSVIPTNFSPSPRDSDPTESGSDNIEERGGRSRKRKRESNIDSNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRU4</accession>
    <name>A0A2R6NRU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UvrD-like helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRU4"/>
    <dbReference type="STRING" id="98765.A0A2R6NRU4"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR75571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="387" mass="43599" checksum="16262E7794EC6489" modified="2018-06-20" version="1">MNSASRGIENALQKEGIPNRLLGGHRFFERMEVINALTPVKDLLAYLQVIDNPKFIPAFTRIINIPGRGIGEKTIAKILQKAGSLKISPLEVVERIHDGKLADIKPPVKRKIGSFVQAMKKLRKLARDGEYPEQLIRQLLDLIKYQDHLKKTQQDFEGRWDNVQELINFATEFESSAVLDAAEALSNKLALARTESQEDDWMDATEYDDLDDLGFPDAKEAKRDKDKARQVILDGEETPLRAFLQASMLSTDTETNEDEETKKDKVTIATCHAAKGLEWPVVFVPAVEKGVFPSARADDIEEERRLLYVACTRAQGFLYLSHCAVRMAMGQSTDKELSEFITAVQRAEVRLFRDSISDVTSQDRATIAAVLNRPVPEADKVKKMIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRW2</accession>
    <name>A0A2R6NRW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRW2"/>
    <dbReference type="OrthoDB" id="2803214at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="339" mass="38185" checksum="95C68B08D04D5649" modified="2018-06-20" version="1">MSFSYAPDFVFKRKRNRLSAIDPSLGFYPASSPQPDATPLAFPNQQDNIDNDDKLQPSGAAKPEQWSQSTQNRADQALAEPTTSAACVPQTPYRESKSDRKREVKDTQNQVTVEGFLRWSAGASSKKLCSRKRRYVQLNEHTQDQSENLILDPEEDLPRKRRRRTQVVHQGASDDDYRPSEEEAEEERPESTRKRAPRRPSKGSLAQRMLRAAVLSHVDIEGGNAIVETNDHRSLKFVSKYCGSPSGRSKPAKWRLVDPRKVASSMRPPDFPLLQTASAKAGLKYQRITSWHPSVAAVNGRRRERKVIQNGVKVPTAPMKFVALKEHEAAVNAIFHTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSB8</accession>
    <name>A0A2R6NSB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSB8"/>
    <dbReference type="STRING" id="98765.A0A2R6NSB8"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="315" mass="34890" checksum="10CC3AE45EAE782E" modified="2018-06-20" version="1">MSHKLAEPYSGKNPVPQIATKLTALINPEHATRAKAAQLQDQSNKQDQKQTQKTAARLAKGYIMHVVDPVTGEELDIKNADEEPDLRNRGENVLENDFPPPGAYTLSFLLARLISNSILVTSLALVPPTLLAYALQFRVYSISRKDFDDRVWHSERVRGLLAGSDFNGDGQVGDEERTKESAEWANAILRGVWPIMNPNLFGSIIDLLEDIMQSSVPKFVDPQHSVRIADLGLGSNAARITAIRSLPDSSAQKSKEDNFRRSEDKNQEDDQGQEQTSSSEEREELDGQHVNVELSFAYRGLPSGKSAASKARNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NST2</accession>
    <name>A0A2R6NST2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000870">
        <property type="protein sequence ID" value="PSR75977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NST2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10571" checksum="CD3F802BA96924CD" modified="2018-06-20" version="1">MDDWAQGRQEPKATARPHRFSPDVITLRYCSNSTIQVVAYGGSGPARTGIFKSAPYSPEELEPIFKNDYGVSAHKHDLRLQQRYAEFDQQIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSV2</accession>
    <name>A0A2R6NSV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BCS1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSV2"/>
    <dbReference type="STRING" id="98765.A0A2R6NSV2"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="24066" checksum="F1B3E00616E2D884" modified="2018-06-20" version="1">MDAKPPAKSSDHVKRERETRSQQLMSGIPWETVTLTTLSRDRSIFPKLLSEARDMAMQNNEGKLVIHTPWGIEWKPFGLPRRKRPLKSVVLGTGISEKIQEDVEAFLKRRQWYANRGRVDLSVLIDDASPQQAKRLFTQFYGQVGDGSQGWESVDEAELEEMGERTAEVVRSKMESGQRVSMAALQGLFIRSSAKESVDRLVTLFQDQRTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTP1</accession>
    <name>A0A2R6NTP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v8400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTP1"/>
    <dbReference type="STRING" id="98765.A0A2R6NTP1"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR76497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="8937" checksum="0BC22536FC7D3747" modified="2018-06-20" version="1">MGAVGGTIWHGIKGARNSPRGDRFVGAMSVIKARAPVTGGNFGVWGGMFSSFDCAVKGWRQKEDMWNAIISGFLTGGCLAARSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUD6</accession>
    <name>A0A2R6NUD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUD6"/>
    <dbReference type="STRING" id="98765.A0A2R6NUD6"/>
    <dbReference type="OrthoDB" id="10248513at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19850" checksum="19656E14145E420B" modified="2018-06-20" version="1">MTDVVLPIVDLDLFLSQPPQSEVVQQECKKAADALINYGALLLHDSRVSEDDNDIFLDLMEDYFAQPEQDLKRDERPELGYQVGVTLENTEKPKCAVDEPCLQIIAKLAPSERPLDITAHSPDPKCRFFWKMSEKPPYETQFPGLNAANVVPQSESIQIRWTAVMEKWGQSMKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUG9</accession>
    <name>A0A2R6NUG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v8220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000835">
        <property type="protein sequence ID" value="PSR76768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUG9"/>
    <dbReference type="STRING" id="98765.A0A2R6NUG9"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR76768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="500" mass="54545" checksum="D5369B7EC8465AA9" modified="2018-06-20" version="1">MRHLTASLPTSSPAILHLGSSKARPPSEDFNRVTGYPDATKQGLIVGCLLLGAFASNIYVGSLADWVGRRASILAGCVVFLIGGSIQTAAQNIHYMYGGRFLAGMGIGMLAMLAPLYQAEIAHPSIRGRLTTLQQFMLGIGALIASFIGYGCFHGLTGQAQWRLPLGIQLLPAVPLAFFILLLPESPRYLAMKGRSEEALQVLGRLHAHGDTTDPFVVAEHREILEQIRIEAEETRDAWVQLFTIKSNLRRLLLGIALQFSVQMTGVSVIQYYSPQIFASIGIDTSTTLGLQSGNSVIALIGEALCIWFIDRLGRRRPLIWANAISGFTFVLGTIIIKLFPAGSNNANASRAFVAMTWLFNLVFSSGIGPLSWAIPVEMFNSATRAKATAITSSAAWISNFMIAQVSPPAFASIGWKFYLVFAICGFTNALFFWAFLPETRGIPLEELDHYFEEVPVFVPGSYAGLKDPNAREQELRRGRVVVGGQAEDVTDILEEKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUL1</accession>
    <name>A0A2R6NUL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000833">
        <property type="protein sequence ID" value="PSR76841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUL1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="271" mass="29015" checksum="D2D7C5AE79753D34" modified="2018-06-20" version="1">MVKAAQKKKQTTTAPPVTRLSTRAKNANAHPGLVDISEESDPEKAQRRSKRKEVKAKAKVAKEVKEANVAEIEQLIAKLQSEIAQRDACEVVSRRYTSIADPEQLASPASPIEEMEEPVVPLSSPIEEIPDNVAMVQGEAGNNRDGSEASQSPFDSDTDATDGADDMEVEETEVEVPGVADAAVVPGGALRRSNAAFFGRNNQGEVVILDRASSGDSYDLHVASEPLSKRQNQPKKRKAVAHASDSEDDIPEAATASRTKASDKRPAKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUQ5</accession>
    <name>A0A2R6NUQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUQ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="6145" checksum="F09B5616DCC5C781" modified="2018-06-20" version="1">MFRNFGPKPDKSILEVFMDPETGDMGAMVRVPTAILPAWCSVHIQNGVNTLRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUW6</accession>
    <name>A0A2R6NUW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex subunit 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000808">
        <property type="protein sequence ID" value="PSR77201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUW6"/>
    <dbReference type="STRING" id="98765.A0A2R6NUW6"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025876">
        <property type="entry name" value="TRAPPC11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12742">
        <property type="entry name" value="Gryzun-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11 C-terminal" evidence="1">
        <location>
            <begin position="334"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="446" mass="48726" checksum="FEA56DADD74D6699" modified="2018-06-20" version="1">MSISKLVLTMKQGSWWIELPMQPSSIRSGRSPTLRWLSSFNPARFTSIHRDSQSSISSVSVRHRPHLVNVSFSHNSPAFLGEKYVITIEVMNVDDRELDIIADIMMQPSEIEAAVSSISYDQETWSNLIKGMSFGVLAPGISVIKTLYLKSSGAVGDRVVDISVQSRNVAAVPVLIASPVSPKSPALIADTGETLRTLVVPTVEPITASFNVSYCRSTKPQLGLADLSTYDEGYWDESDGGEATITAVWTCIGPHDIKVESLKLVKESGYQGMSLATSVESALRSEKCLMNLFPDLECMRSLGDDVPTAAKLHVPIPMRLIIRNRRHYRSANIVVQVEFDASDGFVLAGLRSGRIPVLLPGGEEILTWNLIPIDCGFAKIPKIRVTDRRASVGIQPGSSPEGQQETEVELVKVVDIRRDSRSEGNKIVPGVDRGFASTDVHVLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV29</accession>
    <name>A0A2R6NV29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV29"/>
    <dbReference type="STRING" id="98765.A0A2R6NV29"/>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21935" checksum="B8D7F196CF24AE7A" modified="2018-06-20" version="1">MSTEIEMDNLSKSRTVTHPVAPDEPQGGRLNRDADQTQAVTLWAYTATLLLLILAVPMIFSPSILLYTTETGTERRNALTPLESFLCLHTGILLATFALALLFNIPSSPEVPQRSAGGHPLLVALTSACGLIAFLSYNTTSVGSLAALVFLGSAVIAVWGMWTILFSGSSYISRKTGADKRTSRFLFGNKSAASVQKKEWKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVD8</accession>
    <name>A0A2R6NVD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000812">
        <property type="protein sequence ID" value="PSR77131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVD8"/>
    <dbReference type="STRING" id="98765.A0A2R6NVD8"/>
    <dbReference type="OrthoDB" id="2733714at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="491" mass="54731" checksum="76CAC48278AEABEB" modified="2018-06-20" version="1">MLGLLAPEILLIAAHNQRCVAVELMNKVNEHFGITPRTPWYRRVPSQVWSRLRAHLWRSAKLKASDSASSLQELQLPLDSEKSTSTPTSTRVRWTIVHGFYAAMGGFVFDASAKPSFLPNAYTRAILTPDGLSILLEHEPDLIPDLSEAEIMDKSKADGLAKSLALLQALWFCINCISRLAQRLPLSLLEVTTVAHAFCTFFTYLLWWHKPLNIREPTLISGDRAREACAYMWMASPLKRYRFGGLSHTATGSELAMVWGPHVDQITASLISPSQTIGDVLPRNIEDMSLRIWGSLSPSIFDVQEVLRSTSGAWYSRKWDFETNCEDLSLTSEDIERWTLASKAFIRYGPPPRGRKRTFGSLVTAEAQLHGEWGIDSDAGLLFIAALLTATYGVPHVAAWNTPFATHLEQTLWRCAALVVTTAGTLCSLLSLIDYVPWVGSWLPILGILSLPVAYTVSSAYLLVESFKQLAHLPPAAYQLPSWSNYFPHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVE9</accession>
    <name>A0A2R6NVE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000810">
        <property type="protein sequence ID" value="PSR77164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVE9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11895" checksum="E64A634D54AB13D4" modified="2018-06-20" version="1">MPTSRSYRSPPGTEIDRAFSPTYDYPKPRSHHIIHSGTYVVAKGSQDPSVFWLSSQTEKALEGCIALKHWSRVMVWKKHSILIFSTHVISNGHYLTVTHGNLCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW70</accession>
    <name>A0A2R6NW70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000756">
        <property type="protein sequence ID" value="PSR78146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW70"/>
    <dbReference type="STRING" id="98765.A0A2R6NW70"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="8389" checksum="75C90618FB547423" modified="2018-06-20" version="1">MASSSISTPTTRSRTLLFLSYRDSRASSSRFRRSRIAPQYDDVTGEDEQDRLIDPDAAHITIDTELPPRWYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWU9</accession>
    <name>A0A2R6NWU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v7519</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWU9"/>
    <dbReference type="STRING" id="98765.A0A2R6NWU9"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR78187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="521" mass="57026" checksum="9B0B1E144DB10C31" modified="2018-06-20" version="1">MSRNEPPSQKLASVSFASASSLVLLQLGSRLFTFVLNQILVRLVSPQVFGTAAIQFELLLSTILFLSREGIRNALLRASPSNGTEPGKSRNPSPLISNIALLPILLGIPITVLSAFTYLYTSSYTTTSQPHFRLAVTIYALAAFCELLSEPLYIRAQNELRFDVRVRAEGAAVAFKTVTAFLVLVLSPPEWALVAFALGQAAYGLITLVEFLRVYGRDSEFWLRKVTIDVHGNKVTQYFDPTMLHLSAAMTIQSVVKHFLTEGDKFLVSRLSPLADQGGYAVASNYGSLIARIVFQPIEETSRIFFSKTLSSSSTNAQEDLQTASNTLSVLLLLFTHLFLLLITFAPPYLPLALTLVLPSRYLQTSAPAILRTYVYYIPTMAFNGVLEAFFASTATPADLRAQSRWMLACSVGFVGASVGFARVLGLGDAGLVWANILNLWLRASYAWFFVKRFFESRGVGKMVQLRNNVPPFGVLCTFAASAIVTRWSGRTFGDAPLTLHAQFGHVAIGVTSVAACLVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWW0</accession>
    <name>A0A2R6NWW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWW0"/>
    <dbReference type="STRING" id="98765.A0A2R6NWW0"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015218444" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR78197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="496" mass="55461" checksum="17299C0926ABDB35" modified="2018-06-20" version="1">MFTAIARSLLVVAFCVTSSVATSVQQPLSFGNSATFESYDAQLFRPFEELSLLSNTEFTTLNHPAFPKYDVRIKKSDFCDGTVRAFTGYIDIEARHLFFYFFESRNDPDTDDVIFWTNGGPGCSSSVGLFMELGPCRVTAQDNTTFNPYSWNENANLFFVDQPIGTGFSYAEFGEYVYTTEEAAKDIGAFVAIFFEHFSKFKGRSFHMAGESYGGRYIPVFASYVYDQNPKLVESGVTPINLTSIMIGNGCTDWLTMIPSYHEMQCQPKSAAPIFSISECVRQKRTVSRCVKWLKDSCYDTVDSINCNAATMFCSANIMSPYSMLGYNPYDITKICEDRASLCYPITKNISSFLDRPDVRKLIGVDPSLSGNFSSCNNEVNAGFATTMDRIFPTQFYIAALLERGIRTLIYVGANDWICNWVGNERMTLGLEWTGQEAFNSEPLRDWKIGDDVAGRTRSAGPFTFATISGAGHMAPYDKPAESLELVKRWLAGTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXG3</accession>
    <name>A0A2R6NXG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXG3"/>
    <dbReference type="STRING" id="98765.A0A2R6NXG3"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="414"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="862" mass="94708" checksum="8E89DF2DACAA7500" modified="2018-06-20" version="1">MPPSDFAKASISKVVEQLTTDEAILLTAGVGFWHTHGVPRLGVPPIKVSDGPNGIRGNHFFMGTPAKCLPSSTAIGATFDPALIEEVGRKLLAEECKLKAASVLLAPTCNIQRNPLGGRSFESFSEDPYLSGMIAAAYVKGVQSGGIATAIKHFTGNDKEDDRMAYDSVMSERALREIYLMPFMLAQKHAQPWSFMTAYNRVNGTHASENTHLLQDILRKEWGSDALVMSDWFGVYSIDHAINAGLDLEMPGTNKWRTLDLMNRSIQSRKITARTVKERAKKVLELTQKCAQGAPEILDGDGLEYTRESESDKALMRSLAAQSIVLLKNDNGLLPLKPKEQGLKKIAIVGGNAKAVVLSGGGSASLKPSYFISPYEGILNALGEDDSNVEVTYSEGARAYKTMPTLEFDLLTEDGKKGWTGYWYAHQSDDSMTPLSEPIKTQYIDETKIFISTSYPAGITHRWTLKLKGQLKPREQDTLFEFGLIAAGRAKLFVDDNLVIDNWTKQRRGEAFFGSGSEEEKGTYQLKAGVSHSIFVEYCNVRAPADTDPNEMVMDSNPGIRLGGAEVQDPDELMESAVRLAKEADVVVAVVGLNADWETEGYDRTTLALPGRTDELVSKILQANPKTVVVTQSGSSITMPWADDVPAIVHSWYLGNATGEAIGDVLTGKVNPSGKLSLTFPKRLEDVPSYGHFHSENGQLRYGEDLFVGYKHFHQRKISPLFHFGQGLSYTTFQYSDLRLSKPTYSENDVSVTASVTVTNTGDVAGSDVVQLYVTFPTTSELTHPPLMLKAFAKVRDLASGKSEAVNLQLDKYAVSYWEDRISRWVVESGEYVVRAGRSSAPEDLTLETKLILDQGFEWNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXU1</accession>
    <name>A0A2R6NXU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000692">
        <property type="protein sequence ID" value="PSR79557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXU1"/>
    <dbReference type="OrthoDB" id="2756215at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="311" mass="34132" checksum="E84A97E0A97AD820" modified="2018-06-20" version="1">MAVVARQGSPSEVATAVTGSSHVAVSTAVGMVLGIFVSYQFIPRKRKPSPQLRALAPPAAKPLPLITRIRTRCTTFFQSIRSKLRGNNPANQEPSRRTHRTMRSLYLTPKGTSERDNVRSKFASTLRLNLNFPTSDFLSPTSSPHTPKRTRFYERLGDEGDESHARLLKPDIALISPWSPSEDAFWPSTPTPSFRSKGSEPRTPPPLYPPPPVYVNGTPVRAGFGQAGGIPETPTKKGFGSDSVLTSPTLVDEYEEIDIDGAGTKSLIDEIQQVLEYTRDWAKEDEQVSSFVIADDDEADNEGGSIYSEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYC5</accession>
    <name>A0A2R6NYC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000669">
        <property type="protein sequence ID" value="PSR80106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYC5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="169" mass="17998" checksum="166A662C7DBEECE0" modified="2018-06-20" version="1">MSSSTSLPASILIVLGTRIAISLGDALVLAVTWVKTARNLAEGARIGMRTPLSTMLLRDVVLRTVPILISRFLLNLRQVGSPEIDSQEGYNSQFSVPGFRVPSLASIVGNMGEDLEHSILAEEVEGDVEKNSGSIQAEEGEIPGAIIEAHPSSMNPTPSTQASRLIHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYJ7</accession>
    <name>A0A2R6NYJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000655">
        <property type="protein sequence ID" value="PSR80403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYJ7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="169" mass="18058" checksum="2CE1DE72A8E5EE55" modified="2018-06-20" version="1">MSDTMSDGAGVTTVVMNVCEGVVDEEDGTDEGAEVDERVEDTLDEDTEEGVELGGGWIGGGGWSAQDANSVAVGTICVTLKVAMIGTCMVVSPPAAQRVSIHGKQIGNCENKQGSNIQHALIYFTRRAGDQQTRAQNAGAPEYDVKSPIENSLPYIHARFQLLYSMYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYM0</accession>
    <name>A0A2R6NYM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosylmethionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000652">
        <property type="protein sequence ID" value="PSR80504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYM0"/>
    <dbReference type="STRING" id="98765.A0A2R6NYM0"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45971" checksum="769653D1ECB4EC90" modified="2018-06-20" version="1">MARLSRPTPPTSSLPPLIRLANYSTTRIEQALQNVRAIYFSQALPRLPAPAKPHPTHLIHDSSVPDSGYASAEEDDELEEDEDNDIDLDILRSDAFEREFALRWLTAFTARSDSWVYDPDFPDEEDARAQLVDSAASLLASFAGDDKEEALTRTFSFPLCHTDGKENGPVEVELNDAALLSQDHTSVGLQSWGSCIILAEQMCAEPAAFTLSPGLKHLRILELGAGTGLLSIATAKILQAQQVSSEVIATDYHPSVLENLRGNVTTNFPSSSQTDAPVKVMALDWQNPVYQPPLHQPFDIILAADVIYHPEHAQWIKRCAETLLARPNPTDRNGGVFWLIIPVRSTGRHEGIGTTVEAVFPYAPQVHSSSFEVKSAVGSMSEMELAILSASKVGKHSGIGRADESGYSLFKIGWVRSMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZQ0</accession>
    <name>A0A2R6NZQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v6571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000630">
        <property type="protein sequence ID" value="PSR80981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZQ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NZQ0"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="185"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR80981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="686" mass="78031" checksum="82DAC828FC8DA56E" modified="2018-06-20" version="1">METRFLSQHSSNPLEVHSSDARNRAYVRQYRKAVKQAGGEDQSLPSSDDPLDGLPSPAVQEYQNHIAQLYHKDKNMKPGASTSKQHLQRRPVPEGYVDLDEEMESDDELAIAEQEPRPEEQEPEVIVEEQEQMEDADAEHGSDDNQQGDIDEELTIYLKTKEEREEIAQEIADLQAAVPQLTQDYKIVDRLGAGTFSSVYKAIDLGYHTKWDNSVWHGIHRAPSSAYYQAEARPPGSNVYVAVKRIYVTSGPERIRNEIAIMEDCRGCRHVSQLITAFRQYDQIVAIMPYHRNLDFRDFYRVLPLEGVKAYFRCMFRALRDIHGRAIIHRDVKPANFLFDPRTGIGTLCDFGLACRIEKGPTHGQCLHTPPTRQHPHGKIRPTEEHDIEYIKKMQREARQKSLWPSDRVGYPEKDTRPPSKANRAGTRGFRAPEVLLKCGEQSGAIDVWSAGMIFLFFLTRKFPLFQSSDDVEALMEIAAIIGKRKMEKTATLHSRTFITNIPSLSQEGVSWREFVERLNPKLREPPKPDHRFYPYTTPAWSETRPPPSSSSPTSHSRYSASRYSSGSRSPSPATQESYAADIDNALDLLEQIMQPEAVKRMTPRAALAHPFLKDPDEPDDDEFVPHPFGEGVCGDYHFHDEVTEEPCVRVRAANGKIVVRRLMAGEGVCIGRMPCEFHKKGYGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0X7</accession>
    <name>A0A2R6P0X7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0X7"/>
    <dbReference type="STRING" id="98765.A0A2R6P0X7"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28714" checksum="A9D4E7F9C124DB0C" modified="2018-06-20" version="1">MEQIANDLAQQLFGQLLLTPPTQRLIVGIAGVPASGKSTLSRLLLDKTNELWRKQGPRTDNNYSDDVVVLVGLDGWHLTRAQLDAFPDPKHAHDRRGAHWTFDGESYVEFMQQLRQPLSSKADQEQIIIHAPSFSHELKDPTPLAIPVFPHHRLIIIEGLYTFLGIEPWIAAGKMLDERWWVELGEDEARARLLARHVSSGVAKDLVEAEWRARENDAPNGRFIKEHMLEPTRVIRSVEDPVCKAPPTAEIHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1I7</accession>
    <name>A0A2R6P1I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1I7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1I7"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="62"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="150"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR83455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="433" mass="46794" checksum="FE1161A158EC22BC" modified="2018-06-20" version="1">MAILLGERAHLIEFPSLLLPPGATTGSIVNISVQQNHAEEKKRDAEFWTLQNDILQNYGVKAPENPKLELRNVTQTSVTLEWPHVELATAKIRSLDIYRNRQRLAAIPSPLTNTSTKLSGLQLDTEYTFQLILRTTAGTFPSNVLQVRTHTMTDTSGISVCFGNVQDAVLLENAKMALREMGAKWSDKIQIDTTHFVCTTPAATPSGAHVTGSMSSAPGVEYQKALQMSIPVVQPTWILACHSEKKMIPIHPYYLGATPSTPMNSAPFSRPQSMSQATLPTPASRTNSPTAAKANRQSMPPPHRSAASPPSSSFVNQPQSAGSRQFESTPEEASDDDEEAAAARVRKGTMSKNFKFPPPAAEPTPPLPDIPPTVPKHDDVGAGADSDTEEVSLGPAAPSMVEVPPPPPVEKERSSTHDMADEEVGETEEISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P289</accession>
    <name>A0A2R6P289_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P289"/>
    <dbReference type="STRING" id="98765.A0A2R6P289"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="87401" checksum="1BE2533B9DA87DB6" modified="2018-06-20" version="1">MPSSQAHSPFLNLPPELTELTLVFAVARGDVTSISAVAQTCQYMRSLVYGASDQHLWREVFLAAFDDPRLADRADKTDPYKAFRTNRTDCNETDELSREVAVVCEKSRDWGAEYRERVWSLKWFRDSSRVLQRDDGSTGSPEHLKPSTGKQPEVASNARALEALLSIIKTALPSPPTVVISFLPPNSPAIEATLSMSSSHPLPVFPPPPSSYSSFVRRGTALAMLGQPSLSNGTSVAGYPALIFGHDYSKNIRWLQAAVSKGYPHSLTLKISGRELPGGLQAVWNDEAQAREMRAFSKLICCTGFIPIPQEDKNTQENNVSTRGDEDTFIRSTDVIAEDGAMGTTLTYASTFSAESTDDEEEPEPPGQESEDSADDDEGPLKMTIRAQKRRARRVARMRVYNMRYLNMERHWGPFLLPESSTVLQEPGPDYLGPILELFVDHEAGHPNHPHHHHHHHHHHHDHGENDADQVNESDSDEESDDDDDDDDDDAVGAGPLLQFPPEPFGIIPTSNELRADWTYLAAARIVVEANLREAVSPELLSGLVWLDGLRRGSAPKAVVPEQLEWERSGMTETDDAISGWDWAGIAGEWKRCVCWMDYRDLVSKCPCKYSKHPCLLTNEKSPLEQNLTGTFEDPNLEEAVRIVPMRLRVVSYSRSSIPEYFHWPDIHVVGETSGPAGSGTIRQMKGTIGFIADGSIRWNLVSSANDTEPAEWVTEGVQIGEATSGMGVLGMWTGAQHERMDPLGKSQSGYGYNKTYVSLQVLSGHGKLAESLPVVHAVLFSIMQAIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2B6</accession>
    <name>A0A2R6P2B6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2B6"/>
    <dbReference type="STRING" id="98765.A0A2R6P2B6"/>
    <dbReference type="OrthoDB" id="2767875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR84222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="224" mass="25402" checksum="E20AC9218241364A" modified="2018-06-20" version="1">MSPMDIEFKPLLTDSRPRDSEALAQETRDGLLQGRCPSAYRSVIFWISITVHGIITITLALALYNDHDHDRHLLREKPSCTKLDLSFWGTLMVLPRLYSGLSLLKKSTKLGLTCTTNVMRKALRADYYADPETGDIGNIVKNELHGHLDHCVDMLRQALMCSADISPLVWQWSEKARIAKPASDVMHTCRNFDNIVEWAKTNRIKHHFDTTARIEDTVAPTGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ52</accession>
    <name>A0A2R6PJ52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000486">
        <property type="protein sequence ID" value="PSR91969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ52"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR91969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6661" checksum="3426991D55D62071" modified="2018-06-20" version="1">MCGIAYTGLTFFTIKALIGLHIYVVTQFIIKPSDTTSPTPTNYSWNMNDTNNNGGWGTTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN95</accession>
    <name>A0A2R6PN95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">DEAD-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v4504</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN95"/>
    <dbReference type="STRING" id="98765.A0A2R6PN95"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="46"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="244"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR94076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="49178" checksum="46E8E9E440C6429B" modified="2018-06-20" version="1">MPAPEEASTSTAAPTTFKSLGLIDPLLEAISQLNYTVPTEIQTAALPHALEGRDIIGVASTGSGKTAAFALPILQKLWEDPKGLFACVLAPTRELAYQISQQFESLGSAMGVRCATIVGGMDMMSQSVALAKRPHIVVATPGRLQDHLENTKGFSLRSLQFLVLDEADRLLDMDFGPIIDKILKVIPQNRTTYLFSATMTTKVAKLQRASLSNPVRVEVSEKYSTVSTLLQYYLFIPLVQKDVNLIHLANSLAQNSIIIFTRTVHDAQRLSIILRTLGFPAVPLHGQLSQSARLGALGKFKSGGRRVLVATDVASRGLDIPHVDVVINYDIPTHSKDYIHRVGRTARAGRSGKSVTLVSQYDVELLQRIETVLGKKMEQWPTDAEEIALLRERVDEASRVAVHEMKDQARSGHGRKRAREEGGGKDDRDRDDDTVEAGMPKKKSKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNF2</accession>
    <name>A0A2R6PNF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNF2"/>
    <dbReference type="STRING" id="98765.A0A2R6PNF2"/>
    <dbReference type="OrthoDB" id="3263880at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="471" mass="52569" checksum="E1B75733CBBD3FC4" modified="2018-06-20" version="1">MALVVWAASFGINEYGLEDSQEPPADTRQRKDLINEMLQEMLYLIDLHGILRKASWDGVRLLLLLLPLTQGPKARQREDVKEDLLQYVWDTLDQCWKELDDLRSVGTGEIIEVEDMERFIHDNVVREALKQRLVSQPPHDTYHADGDTALTRKYERILRLHDKAKLRCQSVVRDVVAIIQRNLGTSFFQYDASLVRDGCFFAAFLLAGETGSSEDVEACLQALNEMRWVFSKSEERMHTVRMVWQSRMQQTRSLGRTHSSSPMRDSHPNLPGQDMPYQRRYPSRAVTIPPLTIPDSSMLRTSSAPNTACTQDHGWSSSISTGSSQTNSQTRSNSLRGSPMMNETPPYLDSPQVTAVPDPSTSKNSLINPPSVLLSSTVPSAFDRPMDTDGGYYYHHYGHNVSGSSSQSGSHPGPSNVSGSLSLPSYHPSYLDDHSMGYSNSSISHTSGPLLPASSSADNDECVFAADSYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNM0</accession>
    <name>A0A2R6PNM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNM0"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="203" mass="22684" checksum="010BC0B8700121B0" modified="2018-06-20" version="1">MSDTRDDALEHPTHDNASSSAPITNSDAPRYNIFTNYSVVIDHPLDEVFKVLGDADGMERVVRLSGLCSGFTLQTDKSDMICTPGDAPLSESSVRTIPAGQQFAPGGRLLSRRFFHLQEAIPIIFGLFNRKVNIYGTQTWDPEEKVALYESTAEMGVVIWKLRRFQEIEDGEKKKTKVSETIKGRAPALLQYIVQKQAVVSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNR1</accession>
    <name>A0A2R6PNR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000452">
        <property type="protein sequence ID" value="PSR94371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNR1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="10367" checksum="3D5FEB0053579CB6" modified="2018-06-20" version="1">MPEMAPCGAILDRLSRWSRLKFDACAKCQVRRPATRPHFQAIVLTLCVYAPPPCAHQNHQLPSKFPPPTIPRHLERLMNTFPRLSVYIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVJ8</accession>
    <name>A0A2R6PVJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000430">
        <property type="protein sequence ID" value="PSR97727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVJ8"/>
    <dbReference type="STRING" id="98765.A0A2R6PVJ8"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR97727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="427" mass="48005" checksum="8024080B2349138D" modified="2018-06-20" version="1">MSPQLKYPKVSGKVYRAVNIPEHRVAACKVVRLTPETTKTERKTLDKEIKVHAALRHRNVLEFISAVIVEPDGGSLYIPAVYMLLELAAGGDLFDKIAPDVGLGEDMAHYYFCQVVAGLDYIHKEGVCHRDLKPENILLDAAGVLKISDFGLSSVYKLKQTGKTRLLSERCGSLPYVAPELSSPEPYEAEPIDIWGSGVILFTLLTGSTPWDEPTKKSYEYTRYLTGECFNDDPWNRLSRDVLDLITGMLAPNPGRRTKINEIFRHRWMQRPSQIAEQGLVAIADKLTESLRTTGDLDIANANMVFASRVDADGDQIMLTAANNTQFTQSLLLFSQTQTGRRYTPSLTRFYASLPPADLLPLITEALEGERVKYKNAETTPDGVIRLRIGGFDKRKLIFKGWVELEEFERDDAQGAFCIMHRDQVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVS6</accession>
    <name>A0A2R6PVS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000439">
        <property type="protein sequence ID" value="PSR97375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVS6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6347" checksum="59B57001DC0FC7CD" modified="2018-06-20" version="1">MDSEDIQPPYDIRVIGDIGTGEAGKIGKLHPDKCGIPNTGYAWGFYAGIKLENKLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVV8</accession>
    <name>A0A2R6PVV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVV8"/>
    <dbReference type="STRING" id="98765.A0A2R6PVV8"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR97576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="397" mass="42230" checksum="EFCBCE2F6FC67D1F" modified="2018-06-20" version="1">MSDTSSVSTIYDDRSDQIQYTGPWYPIQSNDPGIHDSALTGVNGRASFSFSFLGSQISVYGVLRHEEANFSIPPTVFSAYSIDNVAMDTYNSVMPTGSDDTRGVLFFASGDLASGTNAHQLSVNITDATPTFPYWLDYIIVSSPSTNTSSPLLSSTGSVHIQSLSTDLRSTSSVPVSPSTKTPIPSHSAMPTLSAQAGNVVSHTAAGLIAGFVFGGILILCLLLGSLFLWRRTRKEMGSPDDGGGIHGVTPFMLSKNHLRSSIATTPMEPSSPHSISGASHIVRNRSWDRSYLPRSPSADPPVEDAEEASSDLAWSAVALRATSTSNVSDIQAPPMLSPRHTHAGRKGNIRTTTANGSTAALPPSINAFDGIHIWDRIAYRGTLLQGSTLPPVYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7C5</accession>
    <name>A0A2R6Q7C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000388">
        <property type="protein sequence ID" value="PSS03318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7C5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="12183" checksum="A9589E6C778409A1" modified="2018-06-20" version="1">MNTNCFLARSIAWESNSWPQASGKNLLNYNSEDIKYHRYQERVYLQHALLQEAAVGLLVWAFKLKATVGDGVRHWPAAASVHGPGPQPFRVPSSNYKSEYFKTEENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBD5</accession>
    <name>A0A2R6QBD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TALE/M-ATYP homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBD5"/>
    <dbReference type="STRING" id="98765.A0A2R6QBD5"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS05436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="721" mass="78014" checksum="CF35FCD07CD99EEC" modified="2018-06-20" version="1">MHQTIRQRFLRAESDYLELRASGLDASALTRFSVQWTILHDDFEDAFRSGLLDDSDIDVAYAVASRVAALGESLSQLENDLGDMTADYLSQVEAALAQLSLADVSSSPPDPPLPKALVSLGSLASPLRPQTYSHPYVAPLYAWLVHNLHNPYPCSSVKNSLAKQVSLSPQSVTNWFKAVRRQVGWSALCKTHYRGQRSIAVSHAGQLFKGYPSSIPIYPAAIPQFFAIKSKLDNLYLVERGIGIDVNGGGIGCKRSRSSSLSSSSVSSTTTESDAYSPASSNSSPSPAPSTDQLIRDSPPHRMPSLVFSSSSDTEDDDPLPELYTNQVDICGGIVGAYERPSKRRRSTYDEESGNRAAIEEPVQWLADSVAFPVDVNTVLPLSPIDMGFTNLDLPCTEVYAAAQPSSLSEPIICTIRKRRFSDADTQHPNKRPRTIVPGAARSHAVSDPLPSQVVGKDGRSAWDEWMSEFESWCGQLPAPVTALDPSVQIDIHVHDFLAPHDSEQHVDSGGIFDPVCSLEVPGHTLQPSSVHNDALIPSEIVPSASLESLGLVSELDGSQISKIKDAISILLNTLETASCANDAPANSLSQLNTDDSTPLTSQDIDILSLGLSVQDPAAIKSESSSNAFMESIPTAHWDQFFTLHEFVDGVQNSVVPETSQAVEVPFLLSDLLDLSALASEPTDELVVADPPFDVLDFVNLPSEQGETWKFEDLITGYVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBJ2</accession>
    <name>A0A2R6QBJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBJ2"/>
    <dbReference type="STRING" id="98765.A0A2R6QBJ2"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS05484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="11395" checksum="61D99B8521B30C4A" modified="2018-06-20" version="1">MAAQATFKSIKSLVPLLDRVLVQRFKPETKTASGIFLPTSATNSPLPEGTVIAVGPGAPNRTGNVVPTNVKAGDRVLLPGWGGNAIKVGDEEYYLYKDSEILAKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBM4</accession>
    <name>A0A2R6QBM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v3808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBM4"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS05526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="160" mass="17701" checksum="5F115F4A19A98DBC" modified="2018-06-20" version="1">MARYEQANDSEHVAEATDPLLRPEERKTEKTPTPLPKVQIGILLFFQLAEPITSQCIYPFINQLISELDITGGDERKVGYYAGLIESLFFATEALFVLQWSRVSDYIGRKPVLLTGMAGLSLSMICFGLSTTFIGLIMSRCLVGMLNGNIGVIKCMMTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEJ1</accession>
    <name>A0A2R6QEJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6QEJ1"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000162">
        <property type="entry name" value="HAD-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37000" checksum="72B7EBF2269C2EF8" modified="2018-06-20" version="1">MSAQTTSFYADAVLFDMDGTLTDSISAVEAAWGKVATDIGQDPEYVIAATHGKRAVDNLSQFKPHIKSHEMDDEVTAFEETILYFADAYHTHGPGSQQNSPASSSPATPSLTPGSSAPSSRNTSRASSFAGGLNQLAAFRRPSFLSKISGLLSMSAVREGERAEFDDPIMEEDHEEMLSQEMQLKKDQLKAWQLEAAAVDRSVRILPGVKRMISSIPEGRYAVATSGAKTYAYGCMTRVGITPPKVTITADDKRLKAGKPAPDPFLLAAKELGFDAKKCVVFEDSPSGIRAGVASGATVIAVCTSHERSKIENCGAHFLVDNMEKIACQAVEVDGELKLKFTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEK4</accession>
    <name>A0A2R6QEK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-oxoglutarate dehydrogenase E1 component N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEK4"/>
    <dbReference type="STRING" id="98765.A0A2R6QEK4"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-oxoglutarate dehydrogenase E1 component N-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="173" mass="19137" checksum="38D29A91E85139B9" modified="2018-06-20" version="1">MLHRQAGALRRLPNVALRPHLDQTGPQLHRTLATATPAKPPSTNDPFANGTNAYYVEEMYRLWRQDPKSVHVSWNVYFSGMDKKGLSSPQAFQPPPSIVPMPSGGAPALHGAGGAELDDHLRVSVVSLCIISWAVVKAIHQPGDTLRVRWNDRMVEVDYFDALSALFRLLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIT1</accession>
    <name>A0A2R6QIT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000328">
        <property type="protein sequence ID" value="PSS08908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIT1"/>
    <dbReference type="STRING" id="98765.A0A2R6QIT1"/>
    <dbReference type="OrthoDB" id="3029001at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS08908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="398" mass="44527" checksum="7F570DDA8A1E1FAE" modified="2018-06-20" version="1">MGGFVFDASAEPKFLPNSYTRAVLTPEGLQELLKHDPELIPDLSDEVIMDKSKADGLAKGLLLLQAFWFCINCLSRLAQSLPLSLLEVTTLAHALCTLFTYILWWHKPLSIREPTLISGDRAREICAFMWMASRIEQYHLFGVTTFTGPSELDIAMGPYEKNQQMASVLASQLTSSPWDRLPRDMAALHSRINPDSNFPRYSKHKVRQLLESTSGAWYSRHWRAYMEKVSLTPVDKERWALASKAFLRYDPTTSSTQLVTAETQSHGEIGLDESEPEVPIKPFLAAALLTAVYGAPHIAAWNAPFPSHLQQVLWHSAAVVVTITGTLASILGLALGDTGITIIDFFKDIIVRSLILILPILYTISSAYLIVESFIQLSHLPPETYQIPSWSNYIPHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3X7</accession>
    <name>A0A2R6R3X7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3X7"/>
    <dbReference type="STRING" id="98765.A0A2R6R3X7"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS19950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="13039" checksum="1798E5783A808F03" modified="2018-06-20" version="1">MLRGIYIRLPGYPSVMQPLPTAREKLVISRPCSSTAAPKARLPRLPVPDLAHTLERYVKSLEPFILEDESRGGTPFKEAYDLRSRWAEDFKNGVGQVCQERLKGLFIRSLFHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R759</accession>
    <name>A0A2R6R759_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000275">
        <property type="protein sequence ID" value="PSS22611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R759"/>
    <dbReference type="OrthoDB" id="10693692at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="820" mass="92444" checksum="FB046C344019B320" modified="2018-06-20" version="1">MVLDYVHVVAQHHNKASGRTTTSHIRWVPDTSPVPEYPAPDFHSLLNSISGASAVILSMRHLGAYDGGVEYLPERLMKPLVGLLFHSYPVAFLSDTDCIPPDQPASKGAFPLLVVCGSSKFTAASRMEMAEAVRPTLLEMTRHHDPAIPLPRHYFVYGLHWSQFFLHIFIHLPVYIAGGESDSGHWEFCQIVVSEHTITLEEFQDGCRHNQDDMVLDRWRLTIALASVQRHMSLLEQIIYPSSDASSSQSVAYSPFVNGMADDSIACLSSSCFIADVAPTSNDRFSLPDFPRMRTYWRGPQFSVPAEWIPIDGTIIDAETGIWLDESKEQKRNLGLLYLDHLRTYLVPIPKDIVLSNQFLETYHGPDFLHLVHSPRAYIPISCSTEEDWESNTLPHLYRVADFLAMAAASWHDVNIFIATLLAGFHGYIVRWNPTTIRYPFSTDTPQSQSCIVDFALAIQTILPTTRITIHRARDLPLSISSPAVLLSVRALDMNSVGSSVSPQEINDITQFMKPHLQLMRLYSTYYEKSHPSAQFSPTLLCSFLKAGYLHILSFASGTSELSTPTVQLIDSLPFTLQCESEDNLLDRMRIAMALFTLQRHVAKICSEWDDSCWPRESLADEHECIVDVTGVATPSPSAYMDHDDKSWWYDRAWMSEGESELESDDTESQEDSNDGTDSREESSDDEQSHDGPSDDENSQKGSPDSQDHDQIYEDSTNTGEKPKDAENPDTLAQGDTEEHRDPDYEEDLNYPEDSDEERENGAYSSSRADALKRLRAHSRRLVCRWIRGLPQKQDDVRPSELSHEDSTMIADLCSSRRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RII7</accession>
    <name>A0A2R6RII7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000251">
        <property type="protein sequence ID" value="PSS29842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RII7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="13953" checksum="107EB04CCFB667EA" modified="2018-06-20" version="1">MGPVLPEIEAEDEAAAGGVEKAEGGRMVETIENPWADRLERRLAASAGSKVRVSDGNVVVKGKGGRVIVTVTISTLSVASAGVEVDDKEVAVPMSTETMLFDCTACVGKATVLLVLFAIIPPPTPAICMSDRADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIJ5</accession>
    <name>A0A2R6RIJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000251">
        <property type="protein sequence ID" value="PSS29841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIJ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="14652" checksum="B787E837AEF7F919" modified="2018-06-20" version="1">MDGTAKHCCEAWHGWICHAPNAHAAFAPPTQAIIPAKGVSVACIGCIQTLKFGIESLSIKSVLEKDGKIWRGGRCAPDIRRRRCKKEQDKKGVHGCASGLNSANERVTTVEIDPRAPGSGREEKYEESVASVDISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLM1</accession>
    <name>A0A2R6RLM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLM1"/>
    <dbReference type="STRING" id="98765.A0A2R6RLM1"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="210" mass="23571" checksum="FD48E73D33F58B30" modified="2018-06-20" version="1">MGESSTPQNKTPKLFSIFRKTAPDDSPSTFSWEPPLGPTRTCLYGRNLSPTHSPKVAAFDLDGCLIQSSFVKKAKGSAQAPNFQWWRPGVPNKLREVHQDGLVTFEFSCKPYLTDGRFSIVIITNQALRGSDAIATWKKKIPLIGAASYALMDNRFNRQLSDVPFHILAATARDGYRKPIPGMWYELERIFAEHNVKIGEQSATRRTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLQ5</accession>
    <name>A0A2R6RLQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000231">
        <property type="protein sequence ID" value="PSS30939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLQ5"/>
    <dbReference type="STRING" id="98765.A0A2R6RLQ5"/>
    <dbReference type="OrthoDB" id="2803129at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="258"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS30939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="786" mass="90195" checksum="21DCEEEFCD0FEA49" modified="2018-06-20" version="1">MSAHLGLTTPAGQSVSMVSVRYFLDTFLPPLHPAMDIHKILNRLKRMGTKSRRPITKHNRWWGFNVDPTDRTPVINLTTFKRLADIVRDIVRAGAIRGQTPSLNFHNNPQPIFDSERDETCLPDAYMVMTSVPETRTPWGRIAVSGEYNVEQWYEKENIVKVCESMRNIMREDPRRRFTFGFTIEDTEMKLWYCDRSQTVASQPFNFITDHETLVHFFLSLSYASPVQLGWDPTIAIQEHDLQYRITVQSADGTECIYRTLEVLSNSAASVMYGPGTRVWKVVQIVDGHDYGDPVVLKDCWVSCDRQREGTIHEKLRNAKPSDAFREAFDDSFLTVEQHGDVLIDSGMQRQPDRTPLILPPEEMEKNGYKIPPVSVTMKPRAARSLWREITYTKSRHERKVHYRIVFKEICKPIKRATSLQEVFKALGEICSALKMMYQTGWVHRDVSIGNILIDSHGKARLSDLEYAKDMKDTNDPEFRIGTANFVAVEVQSQEYQFRPVDSPSISSASDTPSIISDDLAEKRLSLESTARPCHSDSSSDIYMPQPMCAFRYNPLHDLESLWWIAVYFIFTTEVANYADLDERGQDRQLGLDGCVMRLFCNFEERKMDMIDGWDRRFLDRCQCLHPSIRPIGRDLERLRVVLVMTYRRCEKHYESIRFKPLEGLHDSIQRLFFRISKEISEEPTLAHVLPATNSHPVSRFVETSSPSNTTSNTTSNTTSNSGKRSRSDSSDEESATVDNGSHVASTSLSGSRKRARIEREQEESAPPRVGMQTRSKTRAQANKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM15</accession>
    <name>A0A2R6RM15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM15"/>
    <dbReference type="STRING" id="98765.A0A2R6RM15"/>
    <dbReference type="OrthoDB" id="3258136at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="26531" checksum="24CE23E274179D11" modified="2018-06-20" version="1">MLFKFTSADLHNATIIDCSTGAVVYRISTAVPGGRSRSLSASSLYSFASSSSLSRERLSSGSQKVTTLSSREGLGLAEITWEENRASLIRIGEEVLAGSAEIFDAAFIKVLPDETLIPTRMEYVWRTTPDSLTLLDDDGEIIGKLHTDCISLEDELFPASKAGAGHSYLELGMIPPTEVLELLVSFLLISALRERMYWITRYVYGQQSLSPNSHKSPLRKLSRKASRSFAGIRDTLFRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM29</accession>
    <name>A0A2R6RM29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v2425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM29"/>
    <dbReference type="STRING" id="98765.A0A2R6RM29"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS31093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="413" mass="45568" checksum="57291B30D75D4313" modified="2018-06-20" version="1">MPRELRKRTERPNYAVLLRHEDEDEAGPSNSNHAQMLDDELDSGSDFAPEPHHENPEEDQEDQEDLLSEQPEEEDQLAEGISPPERIASTSRPSKAKKAARKNVTLVPSVSVSRQPSTFPLPSIHHRHRAIPIHHRNGEVERLKHTPQLFKHCEVASTNSWSSNEVVGARVGKAWGHNVGTGPLWEIMEDRAWFKESAHNDDASEAARRPRVYESIGVPAEWKTLLPGQYLAVAPLPAQDYSLAIGVKKVRPVAACIQIWSLNPSVPPATNETEDRGVMRCDMILCIESGPAHELKWCPLPSNDTIQAREDRNSTPRKLGILAGTFEDGSLSIYAVPYPPDLMVGGDTSGPIYVKVAEPLLRVELENAACWSLDWANSEVLAVGCSNGSIAVYDISEALISKSTGSTQRECPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ82</accession>
    <name>A0A2R6RQ82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RQ82"/>
    <dbReference type="OrthoDB" id="3259825at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1362"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1543"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="950"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1545"/>
            <end position="1568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1638" mass="175143" checksum="84CC843F202EC3B2" modified="2018-06-20" version="1">MNRFRKRSDAKRGQVPVSLREAPQQDSLPPLPPASDFRTSLILPDLTRRFSVLRNSSGEPIGLDELKSKFAEQRARGSENRVSESEEDMILETLSRLRRGNTTQRSNADSDAAPSSGMSMISNFSEDHDRASRISASPSLVGGQSVRSTTTTSSALHGSPSVASLSSAKSRRMSNNLFGSGKFQDHSYMRNAHQRRPPTLSNAGRSVKQSDSATSMNTLSSRPGNNSVYSDTQSLRPTTPESSGYTTSTPSSPNKMLPMKEEALDQVSHSKAFEGVSSSLSPEILGRASLALDEVIRELEEEGDDEIVMERSPIAHVVNGDYATVAKPVSEPSPSSTSLPAFPMEYEPGMALSSDEQLITDEAQRTSPYPSSRTTSPTPRLPGYIPGMPRPMTPRDSSFDSDDQTPSATPRATSPRLPGVSAHAPPLVTQALVSSMHRTNSNASTSRGSRPTSPTVVSPVSPSPLFFHRTTSGRYTPEDRPRNDSNSPSPDTLDSPVLGRRRPISPLSGPAFQPMAAISSSRPGTPSNIVWNMPSNANTNGKGHGRSGSMSGQSMSGHSRNGSTVSIPDVNGDLDHSTTRSLLSPALPDSPWVDNGHASTTSLPMNPEYRPPSAMSGIDLGSPIQIANRPFRSPTPTSGNAYSPTSPTFTEHSTYMNGNGFSSSTRSSRQNGHSSFSLGPAHALLLSPIGNASRSSLESAGSSYHSWDEDHRKDRLFDLFSHLDSQHAEWHDLTNDKSSSSTSKTTPYESQNSEEIVRRQVGLTKSDMLMIQDKLIQSALTKAATPEGRHRAGSVRKRRPSTQSNYSYNGDRAATPAQQPSIAPIAPPSRHSNTDHIAKASALLDSVVDSIQSPQKQTIGLAGTEDNMLSAQPSQIPVLPSPTQRHRALADALFGAEDRDRSSTPSQTLFEMVVVDESHKTTSEQSPSVFPHSPHSQSHGHEAPELTAGPRPTIVSSSTSISAPSTPTTFPGQGHATQLALDVQRRAEAATAALRKSPSIPKMADTTGSTRKRISPNQISSPTLLSASTSVDTIPLPASQSLVNGGPSRLGSRFKKLRGTLKTKAPPHLGEETALHRFDARTPPSAQTATFNPALFASTPVISSATYPSAPRLSPPVIPAVPSSAGPGLKSFISRFRKRPLEVVSPLDRRVGSSGPNIPTPAVSSLAPYERVGVPNVNLQSQSAPASKSQFTPVLPPTPQSPFSQVFSATQPIPEGTAVPTNSASPAASMDEAALKQLFDAASNLGLDQAALNDLIARSPSTSSRSTAWTRLTRSHSAAGSRRSQRPDFRDSGIPQSPVPTEGRPSIDAVSARPSVEVKQLTIRKNPESTSALRPQQAGTDPLKAIVRRTIIVPSDSRTTAMDLNALMRKQSTSRRRRSAGAGSVQSNRSIQDRAPTPPPPRSTGGRRFSTDRSPPVPQLPHSFTAQFDGSSPPNQVETSNSTYDSLYEMYAGDANGRISTNVNSGPGNHLSATPQLAGEEGVLDSGPAVEVIELANGETIWSIVNGLRDDDSESFYDNRASFASEYSADGVKVFFKEHGRKTSKSSNTSFLSRKKQAQPSASNRPETKVFFSSSAQIGRLIENMSRDMDAGSFNITPERVHGHAAHSASSSVGSAADMRWTLEERLEHMLGSMSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZH2</accession>
    <name>A0A2R6RZH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZH2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="7078" checksum="EEFDC58F097E79F6" modified="2018-06-20" version="1">MDRNEGTDVDHAERETRRWGHHEPSREVPRSRRTVSRNLCKRFVWVKEKVVGIFKGFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S025</accession>
    <name>A0A2R6S025_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000111">
        <property type="protein sequence ID" value="PSS35624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S025"/>
    <dbReference type="STRING" id="98765.A0A2R6S025"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="114"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="197"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="323"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS35624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="403" mass="41894" checksum="FDED135CD7D40F43" modified="2018-06-20" version="1" fragment="single">MPEADTTRKRSRSPSDAEQPKHKRANTGATSNDAQLRSSTATVSATAANNSAMEVSRPIDDTAASTPSPSVKAENVDLILGDAGASGDGGADNSSATTSAAPSNSATNSAPPSANIHMRCLIVTQDASIIIGKAGTHVNEIREKSGARVMVSESIPGNPERILNVSGPLDAVSKAFGLIVRRINDEPFDKPSVPGSRAVTIKFMIPNSRMGSVIGKGGAKIKEIQDASGARLNASEGMLPGSTERVLSVSGVADAIHIATYYIGNILIEANERMPSYNNSSYRPSSVSRRAPYSGSSYVPGYSNAYPSTAGPAQSQQHNPPQQLQTQQIYIPNDLVGCIIGKGGAKINEIRHMSASQIKIMEPGAVGVGMNGAPAPAGGEGERLVVITGQPANIQMAVQLLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3S1</accession>
    <name>A0A2R6S3S1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="7">dUTPase</shortName>
            <ecNumber evidence="7">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1213</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02000090">
        <property type="protein sequence ID" value="PSS36937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3S1"/>
    <dbReference type="STRING" id="98765.A0A2R6S3S1"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS36937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="374" mass="42240" checksum="FA93807DECE46DA6" modified="2018-06-20" version="1">MSTTYHPQTDGQTERVNQTLEQYLRCYIDYQKDDWSRLLGPAEFAYNNAAHEGTKETPFFLEYGRHPRAGPTLTKEVHRTDLNDITWNRQQAQEQAKAALKLAAERMKWYYDQGVQKVPFKVGDKVLLDLCDYQTTGRKLNARYLGPYEIVEKLSPVTFKVKWPARMTRIHPVFHASKLIPYADAKISGQKGPTAEPITVDGHEEPDKDSWKPASLLKNSKEAIQEYHKAHPQAICTLDSRQADQTFALLQRDSTLWVELIGGKGPTRRTNDAAGLDLYASRDQVIPSKSRALISTGIKIQLPTGTYGHIAPRSNPIVKDINTIESIIDQDYTGKIQVTLVNTSDLILKINKNDPIAQLIVEQIAVCDVKVTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3V0</accession>
    <name>A0A2R6S3V0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3V0"/>
    <dbReference type="OrthoDB" id="3063716at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="15137" checksum="D39C9EF2EFDD6169" modified="2018-06-20" version="1">MSPKQISERDAPKQQLLKSRGLFNNPKFLSMPLSTPKLPKKIHPSPHGFSADGICCPVVSVTVDAATPKKKPRYRKKTQPPTHRPPPAFWRPLQEWAGKSMGYAMGYEGSEAVPIGGVRQRKYRRDKMRTGVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S426</accession>
    <name>A0A2R6S426_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000086">
        <property type="protein sequence ID" value="PSS37026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S426"/>
    <dbReference type="STRING" id="98765.A0A2R6S426"/>
    <dbReference type="OrthoDB" id="2717878at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26394" checksum="CD0932DC1283BE62" modified="2018-06-20" version="1" fragment="single">MNILRHVYINSTGHLVSSSRNKNSFKLPVTLWVYGKKVQIEALVDSGATTLFINKSIVESNNLVTYKLANPYNVKNADGTFNKSRQIDKFVQAYVEIGSHRTTHLLLITDLGDKNMMLGYTYLLKHNPEIDWQKGEWKFTRCPESCAHRTHKIDLVTEEETDELQLQQREDPWVTPLDKLEEECPENPHIDWFSTENPEDLEIAKCVAEILEMNPEVEDDDTSKWQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4H8</accession>
    <name>A0A2R6S4H8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4H8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9705" checksum="1E498BE1EEDE4C05" modified="2018-06-20" version="1">MAVSGSAGSEIYKRCAWDARGKGAHSWRCRQGFFCELDSGHGERNVDLNADNAEDIPLAGVAPIPTVTYIPILSANHSHRVYFVTSQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S570</accession>
    <name>A0A2R6S570_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin assembly factor 1 subunit A dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S570"/>
    <dbReference type="STRING" id="98765.A0A2R6S570"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="479"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="786" mass="87831" checksum="0B803D574B984A72" modified="2018-06-20" version="1">MSFEKMSETMQDIVRFREMLEQKIETKAHPLSAIPDEHKPVVAKLVHESDRSLQALAKHIQHELLPAQDEDDEEAQKTVGSLLPLSMIEKAVKSIASRNNYGLESANTGGRVTASWQVWRWEINEEFRGWLPKAAKEKAQIRLAERQQAKVDLLSLFQTLPESERNAIVGPKPSAKIPVHKFKAQPKEIIVIDATEAVTNSYKNAQPSSQPKQEISEGVNTEGVDRQSEVESSPSKNGRPKKVLDPEKLAKEKERQEKRLARAEREKKAQEAQDKSRSLMASFFGKTKAASSFGSDGRASSIPKDKEVTSTSGGHEISNIAGPSNITHSEFEKTFRPFMVKKDAELAPINKFRERKKGKKGKGNGLVSTDMDIIVIDDDGDEQVENEDEDIQMMDVAPSNHDFGQLTAEDRLRDAISSFPPTFPLPHHARQTHAEFKSYHNEPIRSLIAQLNEAEIVGDDSAVRSILSRLRSRRRVPAKVLIFADDARPGYFGTWTRNSREVGPRTPFARDVVSLDYTYDSGEEWEEESGEADDVVEDAEDEEVAAEEVDSDLDSWLVDDDEGVEPGTPIEDRAGSPFEFPVPPPPEQPKRKSNDGDPKMNKKRKVVVPLVPFMKGTCWESTIGQCDYEPFSAYRIQLLNDTPFPINPFTFVSIPVDEKPPVPTTTQSHPDSRSFAVPALPERLQVPPSDAATSSSGPSVVKIKKRPVVQPKTPFPDAHIPLLLSKISSLESGSLTFIVETVYKELSEFKVKKNAIEAKVKEIGEKSREGKKLWVIKPEVKALYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5H9</accession>
    <name>A0A2R6S5H9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5H9"/>
    <dbReference type="STRING" id="98765.A0A2R6S5H9"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="132"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="595" mass="66116" checksum="6610DCFE6501CA9C" modified="2018-06-20" version="1" fragment="single">TRTILISCERSIAAYLLSILVIHRFSCQPCLTDIFHHLGVLIALEVNRIFWIAFLKISLRSVQGVRSSFLKTYSFRSFHCTMPSTTHTDSPSTMQGKDIESSFGRRSDSEFIVTAPPAHLSRTVWWKMDLYILPIATLIFFLSFLDRGNIGNARVAGMQKELNMTNNQYSIALTVTYVPYILIELPSNLLLKRVGPNKLLPAMLTLWGIVTIFQGFITTYAGLVICRFFLGLFEGGLLPGLALYLASFYPRQKLQFRISVFFASSSLAGAFSGLLATAIIRMEGVGGKHGWAWIFILEGVFTVFCGIASFFLMSATPDTASFLTQEEKEFIDFELRRDGVRAQKSSDDEFSWAEVRKAFRQPHMLIMAIAGFLNGTTHERTAIRRVIRLYVSFLPTLPSVPAGLSLHGLVSIITSFLSDLYGRRGWTISFLAVISIVGFGMFLGMFPSILCLVMLAPFTDIMVAGSEDSQVRYGSLFLLLPGTYCAAPPLSAWIANNAAPHVRRATALAFLTTMTNSGGILSTWLLGSLSAAPKYTKASVTFLIFQVGILVCAQLNLGYLMMRNSEKTVIRQSLLDRNEEQGGLGDESAWFEYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5N0</accession>
    <name>A0A2R6S5N0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5N0"/>
    <dbReference type="STRING" id="98765.A0A2R6S5N0"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="300" mass="33448" checksum="512C00EC803345A4" modified="2018-06-20" version="1">MSPTWSCTPAIGNTLGFISPRQAIRAVWNVQPWHTRHSTEETRNFVADKLRVVLQGGQVDSSSPPSIDDDRVQSINSAAIRHFIHAFRRHAVTNQIALTHPYIPVVSHSSIFPLYNPAALDILVFWEIPSQGRSGHLLVSGLNLGAIHAPLKEIIEEAEGAKVKRNMYAETERERKDILQAVRNCEWNAEMDPVTVAVKEGFVVEHDFSKGSLFPPSYTGRLTHRLQLEPCENSTLHVALLISKPGSYALNSWRVQSEVGELSSRSVEFDAHGWRARHRYEQGPPTGDHASVTVKAISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6J4</accession>
    <name>A0A2R6S6J4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000020">
        <property type="protein sequence ID" value="PSS37910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6J4"/>
    <dbReference type="STRING" id="98765.A0A2R6S6J4"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37243" checksum="AE855EA09DB7D663" modified="2018-06-20" version="1">MSTFDLPCTTALDTTGKPLLDSEFQFVPPNATSIPEFSITLTGPIQPLWFYCRQAGHCQSGMVFAVNPTAEQSFANFQTNAMNFGVQSNLATTVSGATVTISPMIVTTTVISSPPSTTPSRGRPPNQMSSKHRRKIGPIAIAAVVICSVLVVFLFIAVWLWKSSRSPRFNKFLNILHIRSRNRGIQWRTKEIDDDVEHITYADTETTRQANRISPFALYAPPLGQPRTSETRLVSDGAHDDSLTSSESHCESGSEVLTSAGPSQFQGHSSMSNLSPPVSETSAYNPPAQRPVSQIHEIDGGVRLAGGYPGDPPEEAQVTPNLYPTLPPPYMDFRHPRNIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S735</accession>
    <name>A0A2R6S735_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S735"/>
    <dbReference type="STRING" id="98765.A0A2R6S735"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="361" mass="38236" checksum="28B9D7E96207BE15" modified="2018-06-20" version="1">MQPITTKFTQLLNINSPIVAAPMAFASTADLAAAVTGAGGYGFVGAGMSSFSFISTTPKADSYLTGFDSSEKLKETLQSARKTLKLAADAPLPVGVGFLGWICDMTEASEDPRIGAVLDEKPTAVWFAFGNDLGKYVATVRAHDAKRAHKTKVFVCCNSVEEALIATNEWKADVLVAQGVEAGGHGSSHSPPLLNFIPAIKAALPNGPPVIAAGGIATGAQVAGLLTMGADGVVLGTRFLFTPECCYTDAMKKVLVESGFETTERSNAYDQAFETDFWPSKIDGRAINTNDLMKDYKAGLPLEERIKRFKDATAAGQDSHLIMWAGVGVAHTNKISPAADVFDEVHTATVKHLQQVPILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NED1</accession>
    <name>A0A2R6NED1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NED1"/>
    <dbReference type="STRING" id="98765.A0A2R6NED1"/>
    <dbReference type="OrthoDB" id="2802198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160:SF19">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="542"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="626"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="745"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="854"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="921" mass="101159" checksum="776E9C8A17146D92" modified="2018-06-20" version="1">MVSTKATKKAKFTYAEIRKNAETQKDTLGPQWSTWITRAINKLVSPFFVPQRSHSNQSVAQESQGVLAPTEPGHVAFTPDAKRARETIDTPGTPKSATLEGHFWKNITQSVSSRGTKRRWSLVAARPGEDEDEDGDEPETPTKSVSRRRISMSHKRTRRLSGDSVTKMTKAELIEKYLKLRKVHEDADNQRDKEELLDLRKQLDATRHELQAARQYREIVYDIDTGPLTPLSESTEAAGSRSPSPFVLQTSDTHAARPPISGVIRTGSGSLIDIISKQPTPAPSTLDDESVDENLEQPQSFGDRPIDVGGDIFSAPRSVAPPFTNPFTETLAVPSVHTNAAGLFDGTVSLSGRDLRLSQLQTLREANVSLISERAELSELISSRNAAIVALQAEIQAQKDLVSTAKVDLTDAETSTADLHSTVTALHVSVQSSEASLLQANAVIKEKESVIESLKASREEQEAKLLECERSIASLQAREGRLVEENNDLSQKLAAMSMTEGHLRDALKTGSEDISVLDSRCKELTARCESLDELLLVANSELSSFAEKLDRAEGEVQSTSAERAQALDRLEVVDGELAEAKITMATLAEQVKDLSESLDLRTQELSAIRKQEAEQRANNLALETTVVSLQMQTDDLEATVSSLQNDLRASAERLQSLDSMCASKMAAINVLESSRDEAEERVSGLTSQLQETRAKKSALELTADELNHRVLEKIEEITRLTVELATQKRAFNILENDFASASSLNAALAAQMVVKENELSSLQAELEEARDDSRQCQEKMNLLETQKATQARYYESQIGSVEANLTVANAAIDTLRSNLRSVEDARNDLVSLLKQKDSELNTIQFDLDSEKAELSATKSQLGDAINRLEIAEKNVESLLATRKRLESNIESLTEPIKDFLGMQSVYASKLSNALAATNPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF31</accession>
    <name>A0A2R6NF31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001298">
        <property type="protein sequence ID" value="PSR70990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF31"/>
    <dbReference type="STRING" id="98765.A0A2R6NF31"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="11041" checksum="159EAE4EB279E758" modified="2018-06-20" version="1">MRSKTLSPWVAGWLFMNPIPFLLHLPAVTYNFVYQTPKTANEQWKLWYFASWGPDIARSLLIAPQHISLETEYSVGLALPPAFIIHVSGLRVVYPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFE6</accession>
    <name>A0A2R6NFE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v13401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001333">
        <property type="protein sequence ID" value="PSR70722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFE6"/>
    <dbReference type="STRING" id="98765.A0A2R6NFE6"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="318"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="718"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="759"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR70722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="803" mass="87847" checksum="FD527CB5FFD1571C" modified="2018-06-20" version="1">MIDNWNYPGQHSHFLRPSSSSGSGSSSSQSSHLSILTTTSSISSALSDAPHDGLPSPPPSSNGSKTNAFFSSPFAAALDLHPPPPLTRSPSLASSASASSSRLRGSEADDTDTTPRLVSAPAPSSVRSLNDSFFASSSESRPTPPPSLRSFPRTSAPTTPETSPPNSPPPSARSKIAPISRLLPSRVRYTNIDGLPSRESSLGGPSLPYPYPINHRRDFVELDVNEYHKSTSPEQTTSEDFSLRHQPSANPRFKQNALNVFIPHIETGSSSYPTPIALSSSQVVTPPPGPAPALHSGDVVAETSSEDTPREGGEALKLQLVRTLGQGAFSSVWLARDVSGRIGRLEVVRKSSLKRSKSLNRKGSGILKRKGTSKGSLRRKIEGAMPQVKAEGDLEDVERLGSEESVSAWFRERTTSEEDRERNPSGDERKEGRLVALKMTDRSICDRDDRTRVSFVREVEVLKHISHPSIVSFIHAFSTPAHHILVLEHIGGGELFDLVSSPESHSRLDEPVLRRIFGELCRAAGWMHAVGLVHRDIKLENILLTRSAFSPPSSAPLIKLTDFGLSRFIDPAAPLLTTRCGSESYAAPELVTGRPYDGRESDAWACGVVLYALITRRLPFDAMDPAVHEEGMRHEEKHRPPNGRVRGPRKDEKTERKALLMRIAKGEYSWPPLPENEDIPYRGAALVRSEGAQRVAGKLLVRDPRKRSRMMDLWEDDWMRGDGAPSVPLLPEGASFQRHERSATEDSEDSLEGEVGVEAWEEAVDEDSSEWDFDEDDGEDDDDDGVLVDEHDIGPGSVARQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFL0</accession>
    <name>A0A2R6NFL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v13070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFL0"/>
    <dbReference type="STRING" id="98765.A0A2R6NFL0"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="218"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR71101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="740" mass="81232" checksum="6AB2C2A1F028B32C" modified="2018-06-20" version="1">MAPTKKSGTDSKTRSSSSQISLKKVKGENFYRNAKQIGRLKMLNGGKPIRDSDGRIIQAAAFQKGEDETEPGRVQPDRRWFGNTRVISQKALDHFRTSLAGKQHDPYSVLLRRNKLPMALLDDAANPNTQKRSHIVETEPFKDTFGPKAQRKKPRLDVGTFEELSKLGSAAVDVAEQTPGVVTEGNTEPIASTSNVEFPTYSDLIEPIYAKGTSRRIYGELYKVIDSSDVILHVLDARDPMGTLCESVLEYIRKEKSHKQVVLVINKCDLVPNWVTARYIQHLTPRYPTLAFHASPNHSFGKGSLIQLLRQFSQLHSDKKQISVGFIGYPNVGKSSVINTLKSGKVCTVAPVPGETKVWQYITLTRRIYLIDCPGIVPTSAKDTQTSTVLKGVVRVEALATPSEHIPALMERVKPIYLSRTYGIPLPDPDDPSKGWDADTLLDKLARMKGRLLKGGEPALDSVAKIILTDWVRGRIPFFVPPPERPEELNKAEAKAASRKEANLKGKSKAQEQADRLVGVKQNLGSIMQKNTFVAEDVRPLEVEDEGVEGEDAENESDDEGGVAAEEGDNGELSWNDVFKGDRPQGVAEGAPTVFSKSDGSVDMDADNEVSHEENPEEDKKESRMKTNKGNLTNLHSFKYSGLANQKTIDISESGNGIKITTRKQGASPIAVRKGLASSTIRNRSGGRRAAGIVSKLAKRGYRPDLRTAALARASAILASHQEKKPAPPKKVRGSKVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFT8</accession>
    <name>A0A2R6NFT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFT8"/>
    <dbReference type="STRING" id="98765.A0A2R6NFT8"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="187" mass="21027" checksum="A353F558C7145B3B" modified="2018-06-20" version="1">MEVIWSVLTMVLASANNFQTLVVIRFFVGLAESTFYPAIQYVIGSWYKGEELAKRACIFHTASAIGPMFSGFLQTGAYNGLNGVHGLAGWRWLFIIDGIITIPIALLGFMIMPDLPSNTKPSVFYTKEQIEMAQRRMEKAGRKPPSHFTRAKVILQSITRSGHSLTSPYQVLGFFKTWHIYLLTPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGD0</accession>
    <name>A0A2R6NGD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGD0"/>
    <dbReference type="STRING" id="98765.A0A2R6NGD0"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16493" checksum="A164F7CB3201FAC4" modified="2018-06-20" version="1">MKAENILLTHFSARYPKMPQSEVASVPLQDGQMADAVDSNIIAEVAISKDKVYSVLEDRYARSIDFIPPKIDRFVRASAPPVDLSATEQSLLIDYPSKPVLALAFDHARIRIGEMRKLRAYLPAIEQTFAETAEKEDEDINPMKGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIG5</accession>
    <name>A0A2R6NIG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001217">
        <property type="protein sequence ID" value="PSR72091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIG5"/>
    <dbReference type="OrthoDB" id="3014170at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="215" mass="23760" checksum="809B1CFF75216723" modified="2018-06-20" version="1">MTAVGTLWAGNLQRALEEIGTEIKPAVIAEQVQWMLGDEEAGLNRPLYWRSWEELEGSGGVQKSGRLRSEVILFTFYWHLQSITGLSLFDNDDDAPPIGAYTLAIQAVERAYKAHVTGKKVLPTGQTAWFSVDNWGDTFKYAAGRKIKNARASKFSNTIAAFTLRDWETILNDTNVLRTGLKMEGRKKVAGSASGSAYESDEGDSGPEYEVMLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NII6</accession>
    <name>A0A2R6NII6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v11961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NII6"/>
    <dbReference type="STRING" id="98765.A0A2R6NII6"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR72169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="312" mass="33702" checksum="102ECBFECD8EF330" modified="2018-06-20" version="1">MKAHQRNMPEAIRRALSDANISIEEVDGIAFTRGPGMGGCLGAGLMAAKGIAAALGKPLVGVHHMQAHALTVLLTTSVEELPTFPFLTLLISGGHTLLLLATSTTSFQTLATSNDFSIGQSFDKVSRVLGLEWSDIGPGAALEVFCASGPDDEELPNGLPQLPLPMRGQMAFSYSGMLTAVHKYINDQGGAEKIEPLEKLAVARAFQRAAAAHLEEKIAIALKQCHRKGFDIRHLVMSGGVASNMFLRSRIRQLLDTVKSEVPIALLFPPPHLCTDNAVMIAWASMERFQAGDHDDYDVIHMAKWNIEDIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIK4</accession>
    <name>A0A2R6NIK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001206">
        <property type="protein sequence ID" value="PSR72189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIK4"/>
    <dbReference type="STRING" id="98765.A0A2R6NIK4"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="193" mass="20906" checksum="B9986F15701C29EF" modified="2018-06-20" version="1">MADIDRRIAALPSFPGLCCFPEGRGFKQWTGDDSKALMKVYLPALVGHVPPQMLRALSAFMDFCYLVRRDVISEDTLKAIDVALDRFQRECIVFEENIQCLGQMLVTNAHLDKLSAARVDFDARGMLVGPCSILSAATTLDLSEGPSIPEQPSGFDKAKAKEMALIAAEDDDGGPAEDGVTAQVTLAKCPGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIX0</accession>
    <name>A0A2R6NIX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v11875</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIX0"/>
    <dbReference type="STRING" id="98765.A0A2R6NIX0"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="16">
        <location>
            <begin position="143"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR72283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="294" mass="32474" checksum="9A0F3A914E9FA34E" modified="2018-06-20" version="1">MPSVSAHYRWTSLVTGTTITPAYQYVRQNTNYNSPVRIASWAIRMSVANIAHAPMPRSLMLLLTTYAATSVPKPQLPLPKPTPSQRVLSYIIFGPSASDLRISKYSIGWFGPRSGYLPPRRREQYVWDLLHISVRLIELFDSVYMAKAPGNASAFDGSGQVWFKVHQISTVTDGGSSITWPDNGLTQVTFTLPESLPNGQYLLRAEQIALHVRPSLLSLPLASGLMSCILWFRLRAPLAVHNFTFRAVRSTLRVVGSGTPGPLVPIPGVYTGYEPGILISMFALNVMNLSNDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJI1</accession>
    <name>A0A2R6NJI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001160">
        <property type="protein sequence ID" value="PSR72514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJI1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="186" mass="21569" checksum="6C87BD97F9E8A661" modified="2018-06-20" version="1">MEVIPQDPQLAHEFCKFLGEKLKDMKALLDAAVQENELLRREIHTLRREPRHLTNQDRMYSGDEKPQLEVGCREGSCPSAHEVQLLQERNQELEELLNSQSVAHEAKTDEMKEKLEAAISKYKECKLKLRTCRQELQNNKGLPEAPRDENIEIRNKEIDETARGKASILRLRDYGVSFFDIDIPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJT5</accession>
    <name>A0A2R6NJT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear transport factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001148">
        <property type="protein sequence ID" value="PSR72640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJT5"/>
    <dbReference type="STRING" id="98765.A0A2R6NJT5"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="12437" checksum="C53DEAD9638C4112" modified="2018-06-20" version="1">MADINAIAKQFTDFYYTTFDTNRAGLQNLYRASSMLSWEGTQILGAADISEKLTALPFDKVQHKVTTLDAQPSSPSVASLIVSVTGLLLVDDSPNPLQFSQVFQLIPDGGSYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK11</accession>
    <name>A0A2R6NK11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK11"/>
    <dbReference type="STRING" id="98765.A0A2R6NK11"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="22103" checksum="A7C64BFB711AC078" modified="2018-06-20" version="1">MTDTFKEEWMTGPEGHQFYTRTYAAPAVPSAIILFVHGFAEHIGRYEHIHSKYPTRNITLFTFDQRGYGRTALDVAHRSKDSAYGKTNWTWQMGDIEHFATYLAKEHPGVPLFLMGHSMGGGLVLAYFTRPSAPPSEEGVKLFSGVISCSPFLTLTTPKPKLLRWTGAKLASLAPYTPFPADPGVEVSLERGMMSTCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKC9</accession>
    <name>A0A2R6NKC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v11327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NKC9"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="481"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="485"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR72830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1427" mass="158886" checksum="2B92163B48BBF841" modified="2018-06-20" version="1">MKLGCRVVYGAGASIHHVTTAFESRFLVLSDLPLSTESSGLLKFVESVGDIKSFTLNSSVSTARVEYADASLASSAIRSLDGAHYAGGKISARYDVRAVEDGLATLRSTKVKVSWFAPSCIAWAHYDGLSFARKQAEKLNGKIFNGRKISTSFQTPHRNQTESFSVEIKGLPLRFVIAHLKGFCDAHALTVGKPTYQGQDRLPQIRQLLSQFGSVDSIEALPSDPLKTKLVAFAQFSNAEAAERAVSHLHGSKQTFLGRSPVWLEHIHSIRYNLPYSKFSVLKSGIDVLRNNQTLCKLRYYEKNEDGEPLDPVCIRVYGTDPKALGKAKIELEHILNGELLVKEGQQVWDEYLGTPEGLFFLRIVSTNTATFVQCEARLRTVRLFGSDDNQRIVRTKIFEKLEQVEGQKHVLLLERSELRMLVTGGLQMLEEKIGADKLVLDVVRRTLTIRGDDEDIRETRKALSLSQTPGIVPEEGLPDSEESCPVCFCDITDPILMLCGHVYCRSCLQHLLRSTPSSGFVSMHCIAEKPDEDKTGSCGMAIPYDTIRELLSGDEEDKLLEASFLSYINARPEFHYCSTPDCQMIYRTGSDGTVLRCPSCLARVCSACHVEFHEGLDCASYRDNLSGGDEAYRKWREQNNVKACPKCKTDLEKNGGCNHMTCPRCRTHMCWLHFWSQTISEDRHSSSDLSPIRSGIASSLIPSGNLTAPDSLSLAVILPVTSTSLVSLDSTLSALLSLSGDLSEIVLVTSPYIQGNVRLAVQRIISEDSLVFLDVSISSWPDGLEEGAAVLYVARTVQTTRILFLDTTGLDTIDLATREMLVGTFSTLLPVGPRGFDLSGDYFRCILPEEDPQASAFLVPPFSISNLLVPPHDLDSHPVYDTWSALGQHISRARFERVGGVVASRGNSTSSWCTGSPTDLQDSSVLPPAALQILDAPIVAEVDSNTETFPDVVTAFSVSTNETMAIAFPFIRDIVSFGSAICGMLRQGHLVEIMATQEVQTGAVGMQRIILNDDCYAEVVLPVFRSQHDEIHALTNWFASFEGLPEVIVYSPDDYAVNFAVNSAYNTKDTSSPTIIRIPRNELRFCDWMGSLTIQELRTAFLFGDTVNLRINLEQTADVETLRMVDHFTWAHGTKFVHRRVIHGGLLPAIVESWYPSSDDSYGLILEDDVELSPLFYAWIKLSLLRYRYGRVEDVSPGLFGISLYQQKNLELRPEGRHRFNARKAFASAGFSHPNTPYLSQIPCSWGAVYFPEHWREFHEYLTIRLSGTHPMLPINGTVAPGLRSNKWTRSWKKYFIELVFLRGYVMLYPNYKDYASLSTNHLEVGSHVKDMPQDVYERKKKLFMLPLMELPREGTDSVLSETGLLDLPGESMPSWEALPVTDLLGMLTTEGTLQGRGRRRREELLGCDSLDSPESDIRELLCVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKN7</accession>
    <name>A0A2R6NKN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase/oxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKN7"/>
    <dbReference type="STRING" id="98765.A0A2R6NKN7"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="7977" checksum="FE522A6257D9A446" modified="2018-06-20" version="1">MSDGLCAVALQELSGWTNQRKAFGKPLNSQAVIRSKLAAMIARAESVQSWLENLTYQMNNMSYKEQAQKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKP7</accession>
    <name>A0A2R6NKP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKP7"/>
    <dbReference type="STRING" id="98765.A0A2R6NKP7"/>
    <dbReference type="OrthoDB" id="3256438at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="220" mass="24535" checksum="D4021EF15029AE40" modified="2018-06-20" version="1">MPGLSLSSISAASPVPPRKRTMSFSTPQPTKSARTLQRTTSYLSLTDMQASYRHKAGTSASHMSELPYPRPPRPHKDQRERRKAQNRGCNDQITIHLQSSRSQPASKGTRFTITTFRTSSPLAPTRSILPARAAFPRSKPEPDLYKVAITTRMRMSPEGQKILHMGPRLAFSIHTATQELERIVASQPDLDFDINMTSGDSLSSSTWVVVPQDDWEMVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKQ4</accession>
    <name>A0A2R6NKQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">PHLCEN_2v11209</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKQ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NKQ4"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="109"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="215"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="PSR72906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="368" mass="40448" checksum="5045EFBB9810BBCF" modified="2018-06-20" version="1">MNTVKRFAQDVVAPKVHEMDENEMMDKGVIKGLFEQGLMGIETPADLGGSESSFTAAIIAIEELAKVDPSVSVMCDVHNTLVNTVVRKYGTKEQQEKWLPQLAESSLGSFCLSEPASGSDAFALQTRARKEGDSWIINGSKMWITNSYEAEVFLIFANVDPSKGYKGITCFIATKDMGIQIAKKEQKLGIRASSTCTLNFDDMKIPAENVIGEVGKGYKIAIEILNEGRIGIAAQMIGLAQGAFDKAVPYTYQRTQFGQPIGTFQGMQFQIAQAAIDIETARLLTYNAARRKDEGKEFTQQAAMAKYWSSVIAQRVSGSAIEWAGGVGFTRETGIEKFWRDSKIGAIYEGTSNIQLQTIAKYIQKQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMJ0</accession>
    <name>A0A2R6NMJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMJ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NMJ0"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="111" mass="12171" checksum="D5D8A6DDACF267F7" modified="2018-06-20" version="1">MPDSPPRARALEENWISSATLSQVMQARRDDSPVPPRTPEPKSPTLPSFALSTPSATSSRSIDTSPGSPLRAIQFIRRADRDSPVMMRPDTPSKAPRVAASNTPRQPVWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMP4</accession>
    <name>A0A2R6NMP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMP4"/>
    <dbReference type="STRING" id="98765.A0A2R6NMP4"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="133" mass="14263" checksum="78BEBCC43D236423" modified="2018-06-20" version="1">MSHHLFLLSPSDTPLYELTHYSSKPVQSTPSPLASNLPSWSTSAFAGTLTALSGASSAAQAHHVQGGAVRMGGGKDRHVIQMVANASLDAIEDVMRKENLMYLKSVDKFNEWTVSAFVTPGSKDSPLVFVKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMT3</accession>
    <name>A0A2R6NMT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v10600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMT3"/>
    <dbReference type="STRING" id="98765.A0A2R6NMT3"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8080" checksum="E40A63D727BEA940" modified="2018-06-20" version="1">MSAVNPVNPKPFMQELTGKPVYVRLKWGLEYKGFLVSTDGYMNLQLANTEEFQDGKSNGALGEVFIREAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN07</accession>
    <name>A0A2R6NN07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v10431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN07"/>
    <dbReference type="STRING" id="98765.A0A2R6NN07"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="506"/>
            <end position="507"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="551"/>
            <end position="552"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="572" mass="63223" checksum="110D4011A99E21D5" modified="2018-06-20" version="1">MVASLENVANKSFDYIITTGLTLAGRLSEDPKTSVLVLEAGEANLDDPNILRPALHGTHFGNKAYSWDYQTIKQKYVNDRQSGWQRGKGLGGSSGINFLCWTKPPTEDVNDFERLGNPGWNWENFEKFVGRTEGFVEPSEEFKKTNGLSSENWKIGRQGPLALSFPATIDEGELKIQQTFVNSGLPWAKNPASYSPNKDRPNFTVLVSAHVHHVLTEKAQDGKLTAVGVAFEHGGKVHTVNASREVILSAGALKSPQLLELSGIGRKDVLEKIDVPLKLELPGVGENVQEHMFLGMSWELKEDVKFDTWDLLRDPTIAAEHLKLHTTGSGLYTTGIIGFAFTTLDKVTSRAEAIYESIKETVSKLDEKTSPPGLLDQYNILLERFKPGNGSPGCEFISFPGLFSFPNPPEPGKRYATTFVATNYTFSRGTIHSTSNDASKDPEFDAHYFEQDVDLEIFTEMCKFARKMADIAPLKDMIVKELNPGPEVQTHEQMREWVKSTFSTTWHTIGSCSLLPKEKGGVVDPDLKVYGTNNLRVADISVAPLHFGAHPQAMAYGIGEQAAEIIKGKFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN18</accession>
    <name>A0A2R6NN18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN18"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="289" mass="31880" checksum="BF38620A2D888664" modified="2018-06-20" version="1">MSSPEASFNGLDSQGQKGPPGEVKKRKRGATRLSCAECRRLKLRCDRAIPCGSCVKRGCAAICPDGSLTTGKGNRATRFVLASTQDLHEKILELSNRVRDLEDGLRVSHSIHSTDNHPLLSDDLLRIKAPIQREGLTASGSNGNPDEQGGDVVDSFGSLAISDTGRTNFFGQATSSFNEGQQEQDREDRLAALRKLLPAEVLSLAGFFPIAPNISATPDVEAERIDRLRSLFWYLPPADEAADLRLIYFQHAGTTRYHWISLMNMFTINSTTQTLRHPSTTLFFRINLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPN8</accession>
    <name>A0A2R6NPN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPN8"/>
    <dbReference type="STRING" id="98765.A0A2R6NPN8"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37357" checksum="E52AE9D54F6954AA" modified="2018-06-20" version="1">MSVGAGIGLYIAILTVFLMLYRVKGAILIGIFLTSIISWPRPTSVTYFPHTAAGDSAFDFFKQVVTFRPLQKIGNAIDYNYNKGRVWYALITFLYVDILDTTGTLYAMAKFAGLRDPVTLDFENSTIAYCVDAFSISMGALMGTSPVTAFIESATGISEGGKTGITAMVTGIAFFVSVFFAPIFASIPSWATGGALVIVGSLMIRNVRDINWDYVGDSVPAFLTLIIIPLTYNIAYGVIAGIISYVLINGVAWALRKISNDRLAPPNYDAAEVWVIPPGSIVPTWMRFVASRTGLYHEPVMEMHMQQRGGSMDSVSMEHDKHVHVQGRGTPIVLDKPEETTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPR5</accession>
    <name>A0A2R6NPR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPR5"/>
    <dbReference type="STRING" id="98765.A0A2R6NPR5"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="458" mass="48001" checksum="000CCAB01E26F302" modified="2018-06-20" version="1">MSTAFYPTSASFKPQVLSRQEGFHLPSPTPSTPTSTDGNLSNNRNANNSSPISPNAFDTHNLFISPPSYLSVPETFRKFPSSDNVHGPSMDFSEELASLIAHPHPSSHERSTQSPANAYDDYRTSTHNIFDISAPTSHHHHPHSPHSPYPSGQSAFSLPPTSALTHHSLHSPSTSLHTPTHSLHEFTTHAHFNSTVPAIGSSMRYEPQPHTTHNQNGSAHPFALNTSSSNNNAGGEPSSVNSFTSHMSSLSAYSNLSSATNGPNDFSHLHQTRQTPSPVLPPPTPISTTSRNDNFSRSRSRSRSSVSTQPINPANPPSTNGGPTRRTRPKRGSVSSVSPPPLHRGHITQPLVIPGSANAGPGSARSPLSLHTSGWFGMGPSGTAGSLGNGNMGVAGGMGGEFSLPTPESVHGGFASFGSASILSGSPKDLNMNGMLSGAMSVNGAKGDSPPADMAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ36</accession>
    <name>A0A2R6NQ36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ36"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="237" mass="26707" checksum="2838C93BEECBD094" modified="2018-06-20" version="1">MDADTFSAEVERALRRVRSTSDLDDLHIPSRPTRHPRGMQRRSESQWSQRATTYQARHARGVDPTDVRRAFPQIERPQEAAIRLGRTPHPSEAWDINFRFPEEPRQSDAGTPANNTRPPPRGWVGKVMVFFGQAGPDARVRSQLISVVWSLSFGLAQVRAYTLSDRIRLLIGSFTSSSLLWRCWLTLPIARARLCRASLNGMRVKDPLGRGMPFGSDVSYLAVCSHTGPGVENEQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQA5</accession>
    <name>A0A2R6NQA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQA5"/>
    <dbReference type="OrthoDB" id="2757522at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14025" checksum="F39058A14AF1558A" modified="2018-06-20" version="1">MSAPISAISEDVLNHEHDVQQSGSMIRRVSWDVKDGRQAESDISEKTSPMSRHASSTMAAYGGPHSDPPSSSSIFGCSAAMPSEVAFFGPPISGRRPRQEEDGGVRIAGGRPGDRETSSLHTLPPPYNDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQC1</accession>
    <name>A0A2R6NQC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQC1"/>
    <dbReference type="STRING" id="98765.A0A2R6NQC1"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="766"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="895"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="822"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR74732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1152" mass="126740" checksum="C220231C3EAFD8B1" modified="2018-06-20" version="1">MPGLRTVPSGAVFDARIFFTELDTEIELLNQVPKTALPPPTFSQPLSSSSSTATCRTTGRPIPIFAAANTQLPYLSRRDVVAVMPQASRTSSRTANVQKDTTTKAQEQEFKRARGAISCAECRRLKLKCDKTVPCSSCKRRGCASICPNGSLTTGQGTRLHQKIAGMSDRIRQLEIALSILQSSVTREVHPLLRVDLLSIKSGLELHSAINPDTGEPQNNEQLDEDFQYIDAFGTLAVRDDGAQTFYGRSAGSEDEKQVEFQDVSVPALPTPIARLSASFPGAPATSTGASAQLIADTQLEIEEYLPAWPRAKELCDLYLEQAPWFFGAITRRQLSEEVLPLFYPEAEANHNHGYSQQVDSPPTQDRSPQPSSSLTVSTSGLSLPQLKSPDSSTGVATAHDLALIFVVFCFGALTDPSLPPAPHNDEASRYYELTRAALNLEPVLDRPPSVATVQTLSLMGIYQGLVADENSIEKTWALMGLSSKLAQSIGLHRDCARWKLPPGEVQKRRALFWELFITDCWQSLATGRLPSFSLPYVDAELPGDPDQTIANDGTPQPSFPAWKAMWGKQCVAGVVEVTLTSRAPKYSLILDLDRKIRDVQLPKYAQGESPKGASLSETMKHFMPINYRELTLLYVHRCFFAQALTDHPIDPMRSPYAPSFLAGYRSACALISTVREQFNINPVQIARFWVLWTHAFSSAVMLASVVTHGGATKTAQAALGELRQAHDLFDKAARYGGRAVKFLPVIRRLLDKAYRAFSQGFPRPRKDIFTPRQAENEGPDELSIFSGRTRMVATKSARPSTAAMKRSASHRRISPGAVSPSESNTASSDSLSASQSPASSASESPKETADVDFPSLQSYGSSVHPMLVDDMRSFEGQLEAQILNAQQSFYMAHASAEESRPATGTHYSHSPPAEGYGYQPSPYEYNHPHEPDTYQGMPPPPSLPQHVQATMYHQPVPPHPYEHTVYHQPHESGPDQQMYAVPTMYGAVDSPPTTMNDASYQAYHTPPVSFEPTAAYTQVQANGYAAHEYTTGKTHPHPQHLQSQPQPHVWNTPYEAYPGSEPSQFQYTIDQPPLQQHYVETPTSSRPQSMHGDSHNRGHVQQHASLMPPPPMPSVLPVHTGGYSLQETWTSFMQHELPAPMNQGYQAGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQK4</accession>
    <name>A0A2R6NQK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000953">
        <property type="protein sequence ID" value="PSR74861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQK4"/>
    <dbReference type="STRING" id="98765.A0A2R6NQK4"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="22152" checksum="FDF00C53998D51EB" modified="2018-06-20" version="1" fragment="single">MIFVGYKFGSKGYKFWDPSNRSIVYSHDVVFDESVFPRKVANAPSDPSPIPNPSGSGNTAEAPAEPEIDFPNHPDQPADQPRPRSPSPAPAADPDEPEIPQEDHLPQPPPIAPLPRRSTRHNLGQNPSRSHDNVYGDRNPAEIDREVQQEQAYEQARQRRQVLEDRRLENSRQWWRNKVLDQPAPPDPPLPPTNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQR6</accession>
    <name>A0A2R6NQR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQR6"/>
    <dbReference type="STRING" id="98765.A0A2R6NQR6"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="78" mass="8943" checksum="46A40604C63A8F6A" modified="2018-06-20" version="1">MAEEDYTSLDMLSALQDVQFLRSVLLHNLGMTKERDETATRQQKTEVLRSETEAEVVEDWITEVWDLVADIGCKLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQT9</accession>
    <name>A0A2R6NQT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NQT9"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="9786" checksum="52BA8A68385FBC94" modified="2018-06-20" version="1">MFEIVHLVTISAKRGRGYASALVRMVTDMADQQGRATWLASSNVAVNTDFYNSLGFVTVKQFMLGDDNPMWKEAPFPIAVVKVFLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRW0</accession>
    <name>A0A2R6NRW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRW0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="8460" checksum="B50EBAE5097720D8" modified="2018-06-20" version="1">MPATARLVSSTGDRLPRYLERPAVSSQSSSPSNASHVTVYPDHGYKPSIAAPVTGKRRLGMGSHTSAGYSNKKFKVPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSM5</accession>
    <name>A0A2R6NSM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSM5"/>
    <dbReference type="STRING" id="98765.A0A2R6NSM5"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26409" checksum="4C97277E0EB926DD" modified="2018-06-20" version="1">MSLLHLEDFHATNAHLRDSEIALILVDSLSAFYWTDRFTSEQFRGHQDAGSMVQPLQQVRAALERIRSLYDCVVVYTSWKLPPRSKPLPVMQQPTSLLDNDPVPQPMLLSVQSQSTHQNTDSIRRDALMETDAAPTDGEPHQPLVSVSVPLVNPQYSALNMPITHHISLTPAYLPPLLSNLPLVDVMEQEERNRIAITDRGRAIELVVQLGNGDVERFSLCISARDVTLEPTRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSQ0</accession>
    <name>A0A2R6NSQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSQ0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="6910" checksum="7783CCE8ECD8B7FF" modified="2018-06-20" version="1">MPHTPKGKRYASRSRAAKRIRTSTSVEGTIGAVTKLVVGNEGERSSQQLTEPWRVSDTARGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSY5</accession>
    <name>A0A2R6NSY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000862">
        <property type="protein sequence ID" value="PSR76098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSY5"/>
    <dbReference type="STRING" id="98765.A0A2R6NSY5"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="82"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="394"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="633" mass="70119" checksum="65669A37142F0D7D" modified="2018-06-20" version="1">MAPSASKQKRLAEKAAKKSAQSKGFTDSTSASTPTGSVNGSSTNTPLTSMSAATSQEDLVSMAKLQMSAAGVLVSDPKGRDIKIDSYTLSFHGRLLIEGAEISLNYGQRYGLLGENGSGKSTLLQSIAERDIDIPDHIDIYLVSGEAEPSDVNAVDYIVKSAKEKVARLEARIEELSVADDVDELALDATYEELEEMDPNTFEAKAGSILHGLGFSTEMMARPTKDMSGGWRMRVALARALFVKPHLLLLDEPTNHLDLEAVVWLEAYLSMYNHILVITSHSQDFMDSVCTNIMDLTMKKELVYYGGNYSTYVRTKQENEVNQMKAYAKQQDEIAHIKKFIASAGTYANLVRQAKSKQKIIDKMEAAGLIEKVETPRPLRFNFEDVTKLPPPILAFDEVAFSYSGKKEDYLYKNLSFGIDMESRVAIVGQNGTGKSTLLNLVTSALQPCEGTVSRHVGLKLAKYSQHSADQLPYDLSPIEHFQKLYSQKYPEKDIQAWRAQLGRFGLSGAHQTSPIKQLSDGLRNRVVFAQLAMEHPHILLLDEPTNHLDMASIDALASAIKEYEGGVVIVSHDFRLISQVAEELWEVKDRKIKNLTKEDITIVDYKKMLVKNSQASLEKAKLFSKTAAKTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT28</accession>
    <name>A0A2R6NT28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000861">
        <property type="protein sequence ID" value="PSR76121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT28"/>
    <dbReference type="OrthoDB" id="5599874at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="26483" checksum="4C8F6E4754377AC9" modified="2018-06-20" version="1">MRGRPSLHLLGTEKLEDVWLDTKNTVNVQIYFENILCLMPITSAPGTTDEGIRISLSESDDPETNDLLIYGQLLPTEQDAPSSSTSPPKMMHILAARILPNPPPPVNRAPRPDDPTPRLPPAHLFEDTEPFTRRKRELSDASIVFGGGGAKRKKPAEDEQVKRAREVMLNLPKPGGPSASAPKGSRISKEDVIFKVPHLPNRTSSVSDVDSDVFGSVHRKGKERESGSDELEKANKTVRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT63</accession>
    <name>A0A2R6NT63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT63"/>
    <dbReference type="STRING" id="98765.A0A2R6NT63"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="265" mass="30295" checksum="9FB6196BBDB30F7A" modified="2018-06-20" version="1">MREKFKQVAAERMAAEQKVGKSLVDPNVLYVTNFLSINVLNGAHPEEGNEGTATYQADERPCPACRGAISKDRIFSRAAFEPTDTELNGTMDGSSHTDEDYEMADVEAAAQTNPKVNTPRRPRKRVSRKVVHGSPDYEDDEDMSDFIMQSDEDEEEKDRRRRARISLGKQKEKAILISDDSESDDDIVYRAKRGRIAARQQVQPMPRFLPSTKMKCMMESLRTWARDHPNEKVGAKQLKRKLSIVFIVSVKTFLSWYNVWSFQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTA5</accession>
    <name>A0A2R6NTA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000852">
        <property type="protein sequence ID" value="PSR76259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTA5"/>
    <dbReference type="OrthoDB" id="2953893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="133"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="291" mass="32675" checksum="9384210FCE2A790E" modified="2018-06-20" version="1" fragment="single">IYYIAFPNDRPLPKFIVWFLFIVELLQTILVTRDAFNNFGLQYGNVPALDGVGFIWFSVPVVTALISCTVQLFFAWRIFMFARRIWIASIIVLLALTQCGMGIWVGEAVYAIGLFSKLATINVPLSVWLGLMTLTDMIVCTTMTYTLSKSRTGFSATNVMVTKCIRVILETDILCAIFSIMHMVFFVTTASSTHYHLAASLTLSKLYSNSVLALLNTRFRIVGGRDMSPQTDDTSLSYVTFENSTIKVPRLSSRRQKNPLTVEIEITHERNYNNDGIALEDMSPESGLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTD3</accession>
    <name>A0A2R6NTD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000850">
        <property type="protein sequence ID" value="PSR76304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTD3"/>
    <dbReference type="STRING" id="98765.A0A2R6NTD3"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="44289" checksum="FB1323CA79289B31" modified="2018-06-20" version="1">MRYARPEFLNDIASDTPLPMIVDAECGMPLDLGKWECLWEQNADDSDLNPDINNLPKLDPKDQFLLLDAATSSGIFTPSGHPGSASGTSTPTVMPHVSWLRKTEYISREGVSRSSHAAEPKMHIDEPVDVSHSAQLRDIEASFNATDNFDISTIKHPNKPNVTAVESYEIFPDADVWANAYDLFRFSERPGDRPLDAEDPRLDCAILRPMESDGDHFLAYYLTKEDETAVEFKSDRQALPVNGVSSTETAFQFVRDYEVVKVEQEVPNEFLLVIDDGDEGVKSEVDTKSSERRPKGVYYKNIERKMLLKKKRINSYEPAAQKWHAIKVRHVEMSDEEQQERTEILAEVVDPNYLFAKADADAEGEVEEPERGAEDGLMVDEGGEIIDAVDVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTJ1</accession>
    <name>A0A2R6NTJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000847">
        <property type="protein sequence ID" value="PSR76386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTJ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="12587" checksum="7250DF7F17D8D190" modified="2018-06-20" version="1">MTKAQVPSRTNTNKIDCLPHSLLTLWKNATSVKTNKNVSKAREDNLRIMRQTWMLVIFQKGSSHQYAMKKDGAPATRQSGPNDILGNTKTKTAIIMAISAAKRVTIANKMVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTW8</accession>
    <name>A0A2R6NTW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTW8"/>
    <dbReference type="STRING" id="98765.A0A2R6NTW8"/>
    <dbReference type="OrthoDB" id="2782847at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="558" mass="63088" checksum="FCAE2CB81D3306E8" modified="2018-06-20" version="1">MGTRGYKVYRHKRWYFAYYKPYDSYPEGLGVDFLTSVPTDPDKFQMWLNQYRADFDNLLVEREELLARAEDFDDPEEEIEEQLGVLITREQPMNEWVYECDLDRLIFHVDHMPMYPLDHMPPEDIFLASIDTDLYGHRKCSQMTPEEYKFTPESIPPPPVEDLSLLTFRNQPNASTPILPHELLGIAQMPSLVDIVCIRATEVNIGVCLYGWGCTIAQEVMLASPREELSDIAVAMSLSLASIALLPIHLFSEGNPLTVERKQPDSFYWMRRHICLTLVTHLQHERNLEAAVSELVDEISKKSEAQGIVFGVAFSVLHCVLVRVDKTAGGSWRHSGALQFLPSFSATSPDTPGITALVRLRNLPAKDDIQFFHALLSSVPAVDSRPSEDKTIQRPTKLEILSLAPEILDQIIAEIEEPADLRSLALTSTGIMCAVIPHLQHPQVNVNVCEGLILRAVYPAVSDRERQEAQHLRENVQDQNKIKDEEENDPAAKVLSASFVTTYQGKRCVCDVGKLYRLFSPLAASRTQVQSEDTEIPIVQAPDLRPPGFIYRVHISKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU51</accession>
    <name>A0A2R6NU51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000847">
        <property type="protein sequence ID" value="PSR76378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU51"/>
    <dbReference type="STRING" id="98765.A0A2R6NU51"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR76378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="156" mass="17589" checksum="9AB30540304180EF" modified="2018-06-20" version="1">MSAAAVLSPSDCEYSIPTWKRVPSTFDVLFGLRLPYRPPPNAIGAFLWRKRVWVETTFALTMLQPWEKFMLVTIMNTLLTLLVTGLYLYFPTHLSFLFERAKYYLLGLEPSTTITSTTTVAESISKFVSDGWAWGWNETIAGLAKPLGLSTKAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUI6</accession>
    <name>A0A2R6NUI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000825">
        <property type="protein sequence ID" value="PSR76917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUI6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="14518" checksum="8206D26FCA866845" modified="2018-06-20" version="1">MFMQDLGGGVGHRVTQFLTDFLTAPAVDKDEPIEEPDKICSSGVPQETGGISEPDVNDNDEENGKDAGQQDNEDREDNYYGYNGMPSHEDNDGSDIDDDDDDGDADEDDLGPEDGEDEVAEGDELEEVEGFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUJ8</accession>
    <name>A0A2R6NUJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000825">
        <property type="protein sequence ID" value="PSR76918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUJ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NUJ8"/>
    <dbReference type="OrthoDB" id="3267098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="265" mass="30855" checksum="8AB4D5F532F1EBF1" modified="2018-06-20" version="1">MKKLAARDWEDMLQVAIPVFEGLLEEPYNSIVLDLQHMQEELIRRVKKQVEKKESEDKNKTIQPNKPSVSSDHATLSFAESDPLPYTPPKKYDHISQSNQFHQDLNDWLNSNSGDPALKNFVPQLKDHLSAQLMGHRYDGDKHEYTDSKCRALILVNNYTTYDLRRAQDSLNPHMHANVMVTAQEDPKERNGHLYWYARIVRVFHAYIQHVGPLSKNQEPQRVEFLWVCWFGRDMTAPAGFRPRQLHQIGFVDGNDPFVFGFLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUZ7</accession>
    <name>A0A2R6NUZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saccharopine dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000812">
        <property type="protein sequence ID" value="PSR77147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUZ7"/>
    <dbReference type="STRING" id="98765.A0A2R6NUZ7"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR77147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="399" mass="42502" checksum="168BA4E5A72DD43D" modified="2018-06-20" version="1" fragment="single">IGLDPGIDHCSAISLLSSLHARQQRVSSFTSFCGGLPAPEHVQQQQGQGQQQGQGQGEIPLKYKFSWSPRGVLSAALNGAKFKLGGSVHEIEGKDVLKEGFPELPVSEVLKLEGIANRDSLPYAETYALGDINEIRSLVRGTIRYPGFSRLMHAFKSIGLLETETKIVRLHSWTDFARSAVEAKLGVPVQNDTASILSALRLLTPIDPELLDALAYLGIIPQPISTANSSSPAASPPPPPPVPLPRSLPPHAPIDLFASVLAYQLRYLPGERDLVILHHEIVTTSAHGAPHSEEEEPEEHVHSASLTVYGNERASAMARCVGLPLAFAVRAVLEGAVVARGVCGPGAEKAVWGRVLDGLEGVGMGMRESVRVVKGGGVVEKSLLKARMTLVAAAAARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW11</accession>
    <name>A0A2R6NW11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000765">
        <property type="protein sequence ID" value="PSR77963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW11"/>
    <dbReference type="OrthoDB" id="2757062at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8153" checksum="0A05DDBE02C9EB92" modified="2018-06-20" version="1">MALIIESGIIYCISGAFALFATFIRLPYGTLGDIYTPINVQIAGIYPTIVLVLVGLERSMNDTTFPNSIQVDAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW18</accession>
    <name>A0A2R6NW18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000764">
        <property type="protein sequence ID" value="PSR77989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW18"/>
    <dbReference type="STRING" id="98765.A0A2R6NW18"/>
    <dbReference type="OrthoDB" id="3248529at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="88464" checksum="3BC89B8A0FE05649" modified="2018-06-20" version="1">MSTQQNLNTKRKATPNKSESKKRPGVQLPPSPRQKAPKRETVADPRPTKPTTGTRPTSKQANISSKQVTISPPSSKQATISPPSKKAAILPPSKQATISSRSATILTKQATNSNKPPNISTKQATNPTKPATIPNKPATSPAKPTISPTRATIPNRAPIPIQPVTREPHPTSSFSLADTYSFLAELPKFLRGFAWTSTPQNSRRLSPAALSTETAAPLPMPPKRLLEDANIKKALRHYSKAIRVETPFDVDSLQGLLSRHPNRPFVNSVLWSLRNGFWPLDESEWKVEEEDFAGNPATNPSDLQAIRDFRDKEVSAGRWSDPIDELLPYMKISPMFVVWKKEKARVVTDHSASGLNGGIPPAEARVRYDNMHDFAQVLYNLRQQNPNKRYVLWKSDVSSAFLNLPAHPLWQLRQVVNVEGRMYIVRRLVFGNRFSPRAWCSVSALLAWIAGTVYKIYDMQVYMDDFWGLDEEDRLEPFHDAARPRNQVTLLRFWDRIRCPYEDRKQLHGNPLEIIGFWVDANRGEISISPSSIQEAIAAINAFLTTPSRKPVLREWARLAGFLNWVLNVFPWGRPALTEFHRSMGGRTRFYSPVPITAEVAADLTWFKETMPKAIGVRLSDVSRWPDEAADLIIHTDATPNAAISFVHSNQGFTYQIKSSQRAPVTPDIFFFKQLAILFAIHHSTSLPSPRRRLLIYSDSLESVEAFNTLRVKASIHNAVLIATAGIVASTGIDFRVRHISGPTNLRANLLSHRLSEEYSKRFPTDRIHSFLPPRELLPARWRGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW56</accession>
    <name>A0A2R6NW56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000760">
        <property type="protein sequence ID" value="PSR78071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW56"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="488" mass="53606" checksum="11D4F38D0CB3C6A4" modified="2018-06-20" version="1">MPPTPLIPLIPLLPPAPSMPPTSLLPPTPSIPPTLLSPLIPLIPPTPPTPPPMAYKTSTVETRKLEKRKSFSEDVNEETESAPLIAKLAKRKSPSEDTDEEITNAPLNAKSAAADTNKRARRSRPQELETIEETDEIAQVHATCVSPPSPPVASSPPRNMRRSRRIQARSSSCARTNGTPSPVSPPTSPAILQRIENLVGSEPDQRLSSSPKTPRARRITLSPVKSEADEEWVPGPVDQGESSSKKSKAKRKVDVKIDVKGKGKAKPKPKEKGKAKGKGKGKAKGSTAPNVEFVQGSSKATRTSKPVKDTPKPRAIRIEGVVPRCELGCGQIFELTGNPSEDRSHIGNHIRQEHFTTHREVVDAFETKEGVTKNCPWPLPDGELCNKHFDRANTRDLGRHINTLHIVAFEYECSVPDSECLYELAGKSRLRVTRDDSAKRHLDNCHAKYIARQRDKANKDKANKDRADDDRADDDRADDDRADNDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW90</accession>
    <name>A0A2R6NW90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW90"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="8785" checksum="13B3B7AFA072CEFA" modified="2018-06-20" version="1">MWIFGRRKSEYRITHQKHTKKQCTEPDISLVRRKRRTVVDEDEEEYVPDKEVDSLEARAVYRSRSDMNVSKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX36</accession>
    <name>A0A2R6NX36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX36"/>
    <dbReference type="STRING" id="98765.A0A2R6NX36"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="315" mass="34488" checksum="C0AF602C391D3189" modified="2018-06-20" version="1">MPPLCNIKPTNLAAGSGLSYRPVAVFVGGTSGIGAGMARAFAGHRNGDAHIILVGRNRAAAEEVIASFPKPPAGKEDAKYEFVECDVSLMRNVRKTAAELVERLPKLNFLVLTAGMMTLRGRDETDEGIDRKLALHYYSRWRFTYEYVRFESLMPLLQKAKDAGEDAKVMTVLSAGLEAGPIDLNDLGLKKTFSLPNAARSASTYNDLMVKVFAEKHSDMAFTHIAPGVVRTPLAAGQSNDWILKAFSPLTTALGYVIGISPDDSGEYLWHGLYSGDKGAFRRNSSGEDVGDKRLHSTEESKTKLWEHTFEETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX45</accession>
    <name>A0A2R6NX45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v7445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX45"/>
    <dbReference type="STRING" id="98765.A0A2R6NX45"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11369">
        <property type="entry name" value="RNase_PH_RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033196">
        <property type="entry name" value="Rrp43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="48"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR78323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="263" mass="28139" checksum="1A7EF778F5AB7659" modified="2018-06-20" version="1">MKAEASSSTTTEQEALRALTFQRLHPKAYLERFLAEKVRPDGRETNEWRGVSVNVGSISTADGSALVRLGNTTVVCGVKAEIAEPELDRPEHGFLGVLFKTLPPSPLKIAKERPVPNLDLPAICSPKFKPGPPSEEAQVLSDRLNEVLIASGLLSTTSLCIEPGKAVWVLYVDATCINYDGNAFDATLLAMVAALKNNPTAFEEPLLDTTISIAMSDSGELISVMQLGLGSAGDQDVLSQCLATAAVRCKETTPIMKLALCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX68</accession>
    <name>A0A2R6NX68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000717">
        <property type="protein sequence ID" value="PSR78891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX68"/>
    <dbReference type="STRING" id="98765.A0A2R6NX68"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="243" mass="27187" checksum="710DD698094E6A2A" modified="2018-06-20" version="1" fragment="single">REGDSTSIALLVAKAEELTSTVNTFLGKATAMLQDKKKVKRLKWLFKADEAKGLAEKLQAFYGSISAVCAANSIEFTGHIDTSFSELNSRLEQSFASTNDRVQGCFIEIHTHLDTQLVSVREIFQEELERSSKELMHNLLASRVRELRPRANEQRRGKSHGFDQSSVLYGVHTMDVLPALLGQSSMSVQCGTPPSTMTRAAFYHLRRSHRTRLAVNTADAIAIVLPLFGGHPNRWLRFLEIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYB2</accession>
    <name>A0A2R6NYB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYB2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6477" checksum="585E9B54D4041667" modified="2018-06-20" version="1">MPPLKELVRSGQDRNMTSCERRVNCQCARRKSGAAEYYAADREDSPGIHSPRQVQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYU6</accession>
    <name>A0A2R6NYU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v6625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYU6"/>
    <dbReference type="STRING" id="98765.A0A2R6NYU6"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="300"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="686"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR80709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="796" mass="88414" checksum="797E128890D78AEC" modified="2018-06-20" version="1">MSLLDEPIPEDDLMRDRARVFEEFLDSETDLYNYKDDVARMLRLDQRRLIVNIDDLRDYRRDFADGLLKQPVDYLPAFDLALLNIVQRVYDQEKHEIENKSYRIGFSGSFGDHHVSPRTLRAAQLGKMISLEGIVTRCSLVRPKMLKSVHYCPDTRLFHAREYRDATTSTSNLPPTSSVTPQTDDEGHPLVTEFGYCVFRDHQRISIQEMPERAPAGQLPRSTDVIMDDDLVDKCKPGDRIQLVGVYRSVGGGAGGAFKSLILANNINLLSSKIGGGIAQTPLTDSDIRMINQISKRTDIFQLLSQSLAPSIYGHKQIKQAVVLMLLGGAEKNLANGTHIRGDINLLMVGDPSTAKSQVLRFVLGTAPLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAANPIYGQYDVHKDPHKNIALPDSLLSRFDLLFVVTDDVEEERDRLIADHVLRMHRYLPPGVEEGTPVTDSLTQQLSIDGPSTAVVETDGGEPSPFEKYDPLLHVGIRQEEAVSQNTRRKKTKGGKNDILNITFVKKYIQYAKSKPAPVLTKEAADFIVNVYATLRNEQSEKNQKRTSPLTARTLETLIRLATAHAKARLSPKVMEQDAMQAEAILRFALYKEVLKRSRRKKRKLNRGTAAEDDDEEEDGSDEEEEVEEAAARMEGPQPAKEKAVSDPVPAPDPVWGDGSQDVDMDAAPPQAQAGPTDDGGVRPERYVFLRASHDRANSLFIHFPPFFFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P028</accession>
    <name>A0A2R6P028_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-ribosomal peptide synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000604">
        <property type="protein sequence ID" value="PSR81910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P028"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47349" checksum="57060F0333FC44DF" modified="2018-06-20" version="1">MVGIFLACIHHFPYAEHHGAALALGNIVSAVACRNELFLRYLFWVIVKVFQKWTPLWVRIFWTGFLQHIGGIHAGSAASGVAWFIFIVVRSFQNHVAKHTPKIVLGWGVITVATCAITMFAAAPWIRANHHNVFERHHRFAGWTAVAFVWIFVCVTDAVSAEGGFTGSGRRLADAQEFWYSLFITILIAIPWFTVRKVPVEITTPSPRVAVIKFQKGIQQGLLGRISRSAIVEYHGFGIISEGIDSGCHYIIAGVQGDWTRGLVTDVPTHLWTREMKFAGLPYLCHLYRRGIAICTGSGIGAVLSTCLQLDNWFLIWIGSDMEKTFGPILFDMIKRKIPKERYILFDTKKEGCRPDTMKMLKDVYVAFNAEGEPHRRLLAVEWFTNRVLVVIITSNPVGNAELMEGCKENGMHSFGPLWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P047</accession>
    <name>A0A2R6P047_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000602">
        <property type="protein sequence ID" value="PSR81958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P047"/>
    <dbReference type="STRING" id="98765.A0A2R6P047"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="3">
        <location>
            <begin position="143"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR81958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="332" mass="35492" checksum="2CDFF8841EE1B93F" modified="2018-06-20" version="1">MVPIRLGVVGLSSRGWASQALIPPLFDSPLSAKYTITALCTSSEASATDAVAEYSKLTGHTMKGYHGESGLSDIAADPNVDMVVVSVKIPDHYNAVMPAIEAGKDVFVEWTPGNGLDQTLKIAEAAKRKGVRCLVGSQGHHRATMLTIPVGHLIVVLGHVLGDFSEVSASGAVRIPTASFVDLDGKPTGEIIPKTAHDQVALSGILKGEHDGVFANIHCRAGMECTGDKVGGRHLFQWTIDGELGSIEVRNRVEDGPLGCFIATEKRVFLNGEEVSVEREEIDKLGNTGKAWLEFAKGNDGKYTTLDEAVKVHRVLDAALTSIQDGRRVYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P088</accession>
    <name>A0A2R6P088_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000600">
        <property type="protein sequence ID" value="PSR82068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P088"/>
    <dbReference type="OrthoDB" id="2953592at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="10279" checksum="F2678446EA144DD8" modified="2018-06-20" version="1">MSHCARVRSQPIEPAVQWYPATHVSKLLVEFIDRGVGAFRRNTQASYRLLERARIIARKINNLIEFVEVNDDWKVFDTLTLPIEPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0X8</accession>
    <name>A0A2R6P0X8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0X8"/>
    <dbReference type="STRING" id="98765.A0A2R6P0X8"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR82979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29284" checksum="F7EC5FF368B86CFB" modified="2018-06-20" version="1">MAISGYAAAAFQSLTPAKIQFIRNLPKAELHAHLNGCIPVQVLQDLALERLSISSGSDSTANGLPDEVKSGIERLQQGVDLNEIHEFFGLFPAIYSLTSTPTALATATRAVLSQFLDLDAHPTDPQPQAAYLELRSTPRENASMTRMQYLEAVLSEVERYPADRAALIVSLDRRMNARVAEEVVYCAVKLRKSGRRVVGIDLCGDPLTDDTLPFRNSLIGEYALLMAAPPLGLGMTEAEVERVARMGMDSRFPVSLAEPSQLRNSPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0Z0</accession>
    <name>A0A2R6P0Z0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">PHLCEN_2v5959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0Z0"/>
    <dbReference type="STRING" id="98765.A0A2R6P0Z0"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023290565" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023290564" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="490"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="104"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="489"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="586" mass="64118" checksum="D780B42560D3069A" modified="2018-06-20" version="1">MLGLKAKLANGKYHLSTGFSSTGGNVSSRVIRRCIRGGTALLRRANHRLYSSKGGVPPPDSFGGPDVPLHQRLANAWKHTPTKWYPLPVAVGALLLIVIQYRKRLGEREVYVDEEGHEVVKLKGPWHVHVIGALPLRNLSRVWGYVNSLELPVWLRPVGFKLYGWAFGCNLDELEKDLKEYTSLGDFFYRKLKDGVRPVADVVLVSPADGKILHFGTIKGGRVEQIKGSTYSLEALLGREIPDSSRTQVAFPTREMAEVDDKEFAAINGIEYSLHELLGTNAKGSPTSSGTSTPKPESSEGKTTATKFGERTDASVSQEGSISEVVAHDTSVATQMGVRPTLERRGSSTINQVKPGNGLFFTVIYLAPGDYHRFHSPTAWVVEKRRHFVGDLFSVSPWMAKRLENLFVLNERVALLGRWKYGFFGMVPVGATNVGSIKINFDKELRTNVGSRRGHPLGTYTEAVYSGASSILDGQPLLKAQEMGGFCLGSTIVLVFEAPSNFHFTVTAGQKVKVGEALGDITPILAESKKDRASTVYIALVPDGAQMPISAGVTKRLGTSLSVLTLDFAQHFCRGMFSWLSLVDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P195</accession>
    <name>A0A2R6P195_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P195"/>
    <dbReference type="STRING" id="98765.A0A2R6P195"/>
    <dbReference type="OrthoDB" id="3245657at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="39681" checksum="19F7225FDCED601D" modified="2018-06-20" version="1">MHSRLFQDVAQAALVNTTLDVSDPQLVYSPTNEWTFSEYIGSQIDTIRSATFNPATNSSNTTQTASLQFNGSAIYVVGLISHSRFDAVRASDIRFYIDGQLSGNFTAPDPGTGGQGLYTENATLYANSSIPNGSHNFTVQNGRQGGSPSLTVLDYIVYTSDDAESAPQVIQQSPTSSPSSNQSSSTFASSSTSSSTISVMPTTSVSLSAGSSISAHTKDVIIASAVSVGLFVMALLAIILILYRRRSKPQVDPQDDTSTRNLWAPVPFVLHQQTNIAVSVPARLITRTMGMMGQSKRAAPDLLQPQDLHNAALDPPVSLLIDSPFAGEASTSNQPGPSSSNIQHPAHNNWASGASEIAASDVPPPYQSVQGGDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1F8</accession>
    <name>A0A2R6P1F8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000561">
        <property type="protein sequence ID" value="PSR83376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1F8"/>
    <dbReference type="STRING" id="98765.A0A2R6P1F8"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="348" mass="36558" checksum="1EE2053175521289" modified="2018-06-20" version="1">MPTQQKSLLLLEKQGPFAIQNTDIPEPGPGELLVEIHATALNPVDWKIQVYGIFIQDYPAVLGQDAAGIVKELGEGVASFAVGDKVLHQGYFTNRNATFQQYTTVPAEIVAKIPPNLTLNQASTIPLTLATASCGLYNTKSNSGAGFLAPWEEGGLGKYAGQPILVIGGSSSVGQHVIQVAKLSGFSPIITTASARNEGYLKSLGATHVLDRNAIPLSSLSGAVKDITLEPIKLVYDAISETDTQNTSYDILASGGKIVIVLSPAIDESKRTADKEVVSAAGNVHIPAQRAVGVSLYKNLTALLKAGDIKPNNVELVPNGLKGIPVALEKLRAGVSALKLVARPLETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1I4</accession>
    <name>A0A2R6P1I4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 4">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1I4"/>
    <dbReference type="STRING" id="98765.A0A2R6P1I4"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR83442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="197" mass="21949" checksum="A59AA897BA343025" modified="2018-06-20" version="1">MASTTEENPNQPISPVQVLYCEVCTFPLEYCEFGSSFTRCKEWLQKEDPDLYDKYYSEEALQAKLGTLSLEAQTKLEKDTAKKEAKAEAKADAALKKKMASQITIKRIERNKRKHVTSVHGLEAFGVDLKKVAKMFAQKFATGASVTKNPQGLEEIVIQGDVSGEIVEMIEEGTGILKGVPKDNVVQIEEKKKKSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5D0</accession>
    <name>A0A2R6P5D0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000532">
        <property type="protein sequence ID" value="PSR85521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5D0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6672" checksum="5509CE8F8025E616" modified="2018-06-20" version="1">MGRKIVLEGPEYVMDARLVKLCRRIHASHTEAAKYQGWYLAVTGNGFYPESIHEDTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5F4</accession>
    <name>A0A2R6P5F4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000528">
        <property type="protein sequence ID" value="PSR85645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5F4"/>
    <dbReference type="STRING" id="98765.A0A2R6P5F4"/>
    <dbReference type="OrthoDB" id="3260348at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR85645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="262" mass="28566" checksum="3BC9B45F521D2A4C" modified="2018-06-20" version="1">MGYPKGSRVWWCPVGRLGALPLHAAGMYNDKGVLIEGFPNLYVSSYTPTLSSLIASRETAVKGGSGLRLLAVGQSNSLPKVKEEFSKLKSLLPNNVLKIQDGHEAESDKVLGDLRDHPWVHFACHGSLDAGSPFKSGFVLHNNKKISLRDIMQAKLPNAELAFLAACHSAAMESESETPDEVLTLAAAMQFCGFRSIVGTLWTMSDEDGPVLAEKFYMHMLRNGLDDTDVCDSAEAVHLTTKSMREAGVPLHRWTTFVHVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8P5</accession>
    <name>A0A2R6P8P5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000515">
        <property type="protein sequence ID" value="PSR87272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8P5"/>
    <dbReference type="STRING" id="98765.A0A2R6P8P5"/>
    <dbReference type="OrthoDB" id="2717878at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="128" mass="15191" checksum="E5CFD6A4DF55D8C4" modified="2018-06-20" version="1">MLGYTYLLKYNPEINWQKGEWKFTRCPKSCAHRTRKIDLVTEEETNELQLQQKEDPWVTPLDKLGEECPENPHINWFSTKNPKDLKIAKCVTEILEMDPEVEDDDTSKWQTLVPEHLHEFGDIFSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC49</accession>
    <name>A0A2R6PC49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC49"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6816" checksum="AE1B9D7A4458309B" modified="2018-06-20" version="1">MSLYWKLGGQEDTVPIHSLSASRISKTQQLRRRAHCSLFYETDDTDTHTDSFEDHEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCB0</accession>
    <name>A0A2R6PCB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR88982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCB0"/>
    <dbReference type="OrthoDB" id="10644017at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="26486" checksum="157188A8F0EBB03E" modified="2018-06-20" version="1">MTMRQNRRHSLLSSGDAGNRRKATPTVESYTEHAYTITIGDAILDLRSTDHMGFAAMDVILRRVYHEPWKYGHDLAVDSQPPAREESSLTEEKVKMIQEPTECKTIAEVVESAIQLEADDSSTSEEEGSDISDDEDDEDISDDDDEEDSSSSHSSSVNSYARSPLSKCLQDSRPVFAGYHCTISGCGFSASTAEHVRHHRLTSNHGYLLEIDIITPSQPANALHPKPQLTPIKEGAPSAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCE2</accession>
    <name>A0A2R6PCE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ClpP/crotonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR88974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCE2"/>
    <dbReference type="STRING" id="98765.A0A2R6PCE2"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29982" checksum="3392B7A8753F6209" modified="2018-06-20" version="1">MVVHPAECNNIHTQAWLDDSTPSLWIIELHNGTDNRLTTAFITSAIIPALDAVERDWRNSWRAAQTNKGEQGGKGALIIVGNRGQHKFFSNGLDYENAVKNPFFFPNVFNPMLYRLFTFPIPTVAAINGHCFAGGMMLSLSCDYRVMTDGSTRNAWMCMNEVHFGASWPLPFGLIARAKVTDATILRKVALEGHRFTPKEAVQWGLIDHIASGDTEGVLLKAQEVAEAVSGQAKAGAYGLIRSGLHTDVLEALQKELPRSSVALDDAYAKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGC0</accession>
    <name>A0A2R6PGC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000489">
        <property type="protein sequence ID" value="PSR90841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGC0"/>
    <dbReference type="STRING" id="98765.A0A2R6PGC0"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR90841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="300" mass="34246" checksum="BF8B530FC669703B" modified="2018-06-20" version="1">MVNVPHDEQQYLDLIRSVLDTGAVRPDRTGTGTLSIFAPPNLRFSLADATLPLLTTKRTFLRGILEELLWFVHGATDSTLLSQKGVKIWDGNGSKQFLEKRGLGHRREGDLGPVYGFQWRHFGAKYENCDQDYTGEGVDQLKECIRKIKEDPTDRRIILSAWNPADIPQMALPPCHMMCQFYVHLPSTPDEKPKLSCLMYQRSADLGLGIPFNIASYALLTHMIAHITDTEPHELVIQLGDAHVYRDHVDALEVQLKREPRPFPKLRWKRRVENIDDFVSEDFIVEGYEPHPSIAMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMX7</accession>
    <name>A0A2R6PMX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FH2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PMX7"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="362"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="1273"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1680"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="904"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1166"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1690"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1708"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1720"/>
            <end position="1730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR93761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1745" mass="191472" checksum="1803EB78CC835784" modified="2018-06-20" version="1">MEGDPLIVPVVLPSGSLQFATIPSDGVVQSVIDDLTGNGEVLLEVLGDLKSYGWALQRIRKEHNGRQWEEDELEALGNGILGVQTPVAPLLNAVAPAANTQRHFSAFPLTSHLHTPSLRLVSLHPFLVLTCSFLRVPEIHDGFQWKLFISRATTVRSAIDSIVDELGLTKSLPIPGGGSLEYVLEEVWSDEEAEKPVRIPFDTIVSDIIETPYKAIPASVSASRSFRICVPEEWYRRSRSRSSSSASLAPSEDTVRRLEDLQESEDEGEEGDGTAKQKDLGLLTSEIEPGNSQVFTSPSDWRNSISQNRLSSIFESWIHPTATGTNNHATSPEKKAVSEPKLVPQRPSSGPSAAVPSGTQTPQSDRDPVDSSEFEEMLDSLGLKGPRRDAMYQLPPEQRQYLFNQHRAASMSKGTAPKRQISHATQASTFSPASASGLIPRLVPQLTGDSGIMRRFSIVGWGGATSSSPTGSPRSSTDLDSSRKDSISTTDPVESTPLQPQSTGGLWSSWWTSSGGEKGPSTGTGAQQEASKVPKWYVDRIRSGKATDVKLVKHLISLRVHLSTADLDWIEEFVVLCKGMDALGDLLGNLVAKGGKRKKLQNVEETVLLEVIKCIRVLLNTDPGFRHGLSSTILLTHIAYSLHGSSTKLRALASDVLAAICYVSPTEGHKAVLSALSDYRIEFGETFRFQELIGSLRLPDGDINGTDELGYGNEEEGVWEARTASLAFVNALTNFPDSLEERILLREELTRRGLNEVLVALRYMQPPDSVVTQLDIYTEEKFEDEEDLRERSLANHRRTASDSEVLLQDLISTAKQYDELYPEVVRALNSYRHILEKDSDISFKSDIIFVLNKFTEHASHIDNFDDSWCYFVKQFADSVRHITGQSLEAGTAQDGQNIIVGEELDSLRMRVDELSEERSRLQNELSQQVAELSTLRALPLSVTSPTLRNQGKGNGESPQNFHGLVQRLVQKEKQVIQLQGELERLKAQNPSESRELEEKAKRERDRAKWNTLMEEIAKSKLQNDELQTSLGIKEKEVTYLKRALESVYSRFRSREENREPEVDAQLMAARAIEDLTQKDDEIKVLNSEIEKLKAELAVKPRFITEQDFKHRVPPPPPPPPVKPKRAVTAPAMENGTDGTLTTLPSPPPPPPPPPPPPPPPPPPPGSISTAVASTITTPLSPPPPPPPPPPPPPPPPPPPPPPPVAVRSDLSQVEINSSYVSSSFSLPPPPPPPPPPPPPPPPPLPPALSSTVGPGGGPPPPPPPPPGLRSIPPPKIVRPSKRLKPFFWNKLPTPAVSSTIWNETEAEISLDLNDLEATFSIESSPGSTSKSSVTSPKKSSITTLLDITRAQNIAIMLARIKLDHPGIRKAILELDDEKLTIDELRAIGKQLPTSEEVTRLKDFENVGRLAKADQYFAQIMTIPRLSERLDCMLYRRKLEIEIEEIRPELNIVRNASRELRSSPRFRQVLQTVLALGNALNGSTFRGGARGFQLNGLLKLKETKTAKGGDCPTLLHYLARVLLRSDPSAVTFIEDMPHVEAAARVSVQTVIASVQALSSGLSNLQTEIRQLRSVTTPSNDRFISVMQPFVAQVSEGVNALNHMANALDSELQSLLAYFGEIPDSPEAPKPEDFFGLILTFSSSLQKAALDVHDSVPKAPQFVIEDPTTPTAESTIKLGDNAQMSLMPPPTSQSRASSQGRAAGLSLGRGDLDQAIRSMRDGKRRARPHRPVSKIFLDGTRTSRLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN57</accession>
    <name>A0A2R6PN57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN57"/>
    <dbReference type="STRING" id="98765.A0A2R6PN57"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="8">
        <location>
            <begin position="549"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR94042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="761" mass="83650" checksum="00A1794F34DB8DB5" modified="2018-06-20" version="1">MPPKSSSGKEKDLGGEDEVLQAVILADSFNKRFRPLTVGKPRCLLPVCNATLLDWTFESLALAGVQEIFVICRSYAEQVKEAIRESKWSKPSSGIKIVPIITSKETFTPGDAMRDIYTHGIITSDFVLVMGDLVSNVKIDEVVRIHKERRKANKDAIMTMVVKESGGVHRTRSRADTGVFVLDANTSECLHYEAVVGYPPTRHVKIPREVLAEHPEVEIRYDLIDCSIDVCSVEVPSLFQDNFDYGDIRRDFVHGILTSDLLMKSIHCYIMKEGYAARVADTRSYDAVSKDILSRWTFPLVPDDNHPGGHLYEHLRGNKYIAKDSSVVLSRTCKVGANTLIGSQTTVSSGATITASVIGQRCTIGANVVLSHSYVFDDTHIEAGSVIEHSIVGANVKVGEGSRVQRGSLVGDGVVLGKGARLGPFERVSRRRTAGDEEEESDEEWEEVEQSQSKIPEILGEGSNALVWPQGPAEDDEDLDEVERYNNQRLMRIGDTASDLHVSDVDLSDSESDSDAETDTTSGFSRPSSRSSFSLAPSHSQSLHTLSAAAADSEFQAEVTQSLERAFDEGHSVDNAAVELKTLRMASNVELVKVREAVVAAIVERILVVQGDAVGQKREIGKVLGRWGALIDKIGGVDAVETVEVLQVCWPRARHWGVRAKQLIWELCIQYHCARSARQPLFGQLLAALYQDDIVDEDDIRAWHSRPLAKGVGVKPGPLLDGVKYCWAVGQKMIEQFDAQGSESEEESEEGSAGDSEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN67</accession>
    <name>A0A2R6PN67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000465">
        <property type="protein sequence ID" value="PSR93886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN67"/>
    <dbReference type="OrthoDB" id="3020747at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR93886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56561" checksum="5CE88CE781FED77D" modified="2018-06-20" version="1">MLRQIILQYRALYEEERKKSAKRSRHRARTRYGPYGWIRITHVCTLWRAVALETSRLWVDLHLTRLECVEAMLVRSKATPVTVNWHKGNLSLLQPVLRELNRVQSLEILFDEEIWQASNDIYPATFPLPTKLHTLRVGGDVSFAFRENARLGLSIPSIFGQGLRILSVKERRKTQWPLQPFSLLTVLKNLPLLEELDLDVGLGSVNDLSMDSSLTVTLPHLRSLSMRCDSTACLYLLEHLIPTDEARIMLDVQSALDPDFLPEAASIWQSKFPDSTSTALGAILPLQTFRLYYENNRAYLRGWRDLLSLAALNEAECQRQVADLKVSCTSWEIAPVFDYCCDLPLADIQTLQILTDWEQLTGGEELDIAIYLWLDNLSRVHTLSVAASAMKTLSDVLKFKNLLPRLTTLEFHCECSKGGTTYKCIESEDLGNLAEGLKSRKDCHLGIKTIIIPTCINRSSWVLAVKLKKMKPFVDEWRWQMCDDDTTAVVAYYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PW79</accession>
    <name>A0A2R6PW79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000445">
        <property type="protein sequence ID" value="PSR97100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PW79"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="9296" checksum="F2517A0F82C96B58" modified="2018-06-20" version="1">MLVTTVLPNTNSNEIPDRWDILMKSTLSPESYLLYPVQFWEDSRIRLTRSSQHQEKDADTDAILVQTEPQPFKITWSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB37</accession>
    <name>A0A2R6QB37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000379">
        <property type="protein sequence ID" value="PSS05349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB37"/>
    <dbReference type="STRING" id="98765.A0A2R6QB37"/>
    <dbReference type="OrthoDB" id="2796710at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="15947" checksum="C4218D49D8671806" modified="2018-06-20" version="1">MQSPSTPEEQKNYLLYAGELKYLEVVGAVFYATQTQPDIQHAIGVLAQFGSNPGKPHLEALKQVLRYLQGTAHFSLRLGGGSGNVDLIGWTDSDWASNVDLRCSIAGYVFKMTGGCISWSFKKQPTVALSTVEAEYMVSANAAKEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB41</accession>
    <name>A0A2R6QB41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000379">
        <property type="protein sequence ID" value="PSS05348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB41"/>
    <dbReference type="STRING" id="98765.A0A2R6QB41"/>
    <dbReference type="OrthoDB" id="2796020at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="154" mass="17723" checksum="19A01376A547D4B9" modified="2018-06-20" version="1">MSFVANQDWELHQVDVVGAYLQGDLDEEIYMKLPEGIKEPGKEGWCWRLKKALYGLKQSGRQWKKKLDEAMAKLGFEKGQADECLYVLKEDRHIILMVLVYVDDMAVAGKKLALVKRFKCNLAERFDITDGGDLTFILGVQVIRNRQNCTIHMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBH9</accession>
    <name>A0A2R6QBH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBH9"/>
    <dbReference type="STRING" id="98765.A0A2R6QBH9"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="213"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS05493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="939" mass="104057" checksum="1FAFE87AC3308416" modified="2018-06-20" version="1">MVAADPLPGPLRSDDASPQIASSRPGVIARLHALFPTHADSSDSPHINTMREKPRPPPKFLKVRILTWNMHESLPKGELEELLGGIEDRDVPTATIGTLPKLPQNAEHPYHLVVVAGQECPSLSGLPMALGAGFKLIDKDREKTKDKDKDNQASESLKSGKQESEKERDREDEPPRKTRHLSLRHHSHQRVSQEEDTPPNTSSSAHDVHHTAYGWTSMLEDWYTNGGFASTPTPPGGQDEGRESPCPEEDDISLSPKAKSTGDLNARMNAVRKGPYELLIKERMMGLYLAVFIKRDIKDLVRGMSKSAVTAGLIGGRVGNKGGVGISLNIDGTTLLFLNAHLAAHEGKMHHRLANLAKIKTELAVDTFLAPDDPRVMAEDITDRFDFTFLCGDLNFRLDITRLHADWLISRRDYAQALAFDQLRKVMQSGEAFVDFNEAPIDFPPTFKYDVLRSKRSKHRSFRRYSKNPALDMIQHEKLLTEIEERRQDADEERSDEDVEIDVEAASVASTAFTSQSRYTTDGDDPEVEREDYFLSSTSPRTNASTGNLVNKVWSAAAAHKAKAKWVSLISSSPSTPIRKWTKFRQSRNYGRSDSPISPSVGNSPPPEFKSATLPPTPGEEVVELERKEEKYLPPSKSVGSSEQGRLGVPITIAGRSNSSKSTQKSDEKEEEEGTQFNYDSSHKQRVPSWCDRILWKSTVFPGPEIEEEDEDETPLLPPRTRMGNFLHAFKPASLRSRKDSSTSLELTPTSPHPPSELGRLGDTRNGMDGIDTLPAPSRPHVLLHSRSIDSMPIVAKPPPLRSKTNLPSTEELRPRISSLISATHGKSPVLKSPVSPTVHLYPAEGGYDISPTVPPKDFLPSPAPVSSLWRSFLPFLSRDAVPHDVPDDIPPTPESSAPAPRKGDVVCLTYDTLDDRAMRRLEAKSDHRPVIGSYAIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEG7</accession>
    <name>A0A2R6QEG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000361">
        <property type="protein sequence ID" value="PSS06535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEG7"/>
    <dbReference type="STRING" id="98765.A0A2R6QEG7"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1190:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="169"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="545"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS06535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="666" mass="76109" checksum="4CCB6D423F4DD0FE" modified="2018-06-20" version="1">MSTSGLKAIAPVPTAADFLDIVLSKTQRKTPTVIHKNFKISRIRNFYMRKVKFTQDSFDEKLSAILDEFPMLDDLHPFLASLMNVLYDKNHYKLALGQLRTARHLIDHVAKDYVRLLKFGDSLYRCKQLKKAALGRMATIMRRQKDPLAYLEQVRQHISRLPAIDPTARTLLICGYPNVGKSSFINKVTRADVDVQPYAFTTKSLFVGHLDYRYMRWQVIDTPGILDHPLEEMNTIEMQSITALAHLKSCILYFMDLSEQCGYTVEAQCKLFNSIKPLFANKPTMLVMNKIDVTRLEDLTPENRAMVDDIINSEGVLNIQVSCYSDEGVMELKNKACDALLEHRVDTKLKGNKVNSILNRLHVAQPKARDEVVREPFIPESVKEKKKYDKEDPERRRLERDVEAEEGGPGVYNINLKKNYLLSNPDWNEDIIPEVADGKNIADFIDPDILEKLEALEREEERLEAEGFYDEEEDMFDSEDEREAVEAKDSLKKKIVSQGTKKAMKNSAKLPRTVGLRTLSELTSEMTKAGLNPSRIQERAEMLAKVHGAKRKRQREEEDAEMDVDGNGEEAEGEWMDVDEDATPNKRTKGNSGKSIAKGRHEPKTNRQFAGFRDEAQASKAVKLRNLGQRERNMQAKAGEGDRTIKTKMPKHLFAGKRKMGKTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QER8</accession>
    <name>A0A2R6QER8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v3545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QER8"/>
    <dbReference type="STRING" id="98765.A0A2R6QER8"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS06826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="429" mass="47567" checksum="EE1A100810E0978C" modified="2018-06-20" version="1">MLRTTLLRLPRLNPARPPTGATDARSLVFSHIIALRHVSTTPNSLNPGGSKPGHTDAVQQIQPTEPAPPSHESTSQDSSNHVKDPDAPADLPSSETARSTSGPMDVEEMKERLRSWSENAAILVRERADRYTAVAATTFGQLGRELNKVTGYGEIESLKRQVAEQGMLSHELFGLSSILTATTETRIRIAREAARTAKQELEKAVHERAKSQREVNDLLSRKSSWSDDDVGRFTGLVRQDHLYEQAEARAKAKAVYTEDEVDREFTELMRVILHRYHEEQIWSDKIRSASTYGSLTVIGLNLLIFMLAIMIVEPWKRRRLAQTFEKKVEEMSAETIMAFEEKSGDLTAQLKEQQRVVSQLVEAVNRSLQPVAALEAGEVPLETDISLPPSVESNPSRIPQLNAELAWTVATSATVAGVLGWIAGSWFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEY5</accession>
    <name>A0A2R6QEY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEY5"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="37112" checksum="7C6C9D4ADFF317B9" modified="2018-06-20" version="1">MAWELIEDMADRELKDYRPIPHLLRHDFESLFYLSLWCAVTMPVTWDEMKKKKIYRLYIRGWESGTLRSIADRKKVLCGTVGQTDKIAFPPACEGLRPWFRDWNALLATAAMRLEHHRLEKYHADKTNDTLFDEETIGGTLSTESIRRVLSGGKVRRMKLVYAEPEEFVEPGTSRAGDEHLSSHVPAEFLGEVNDNREVEEVQEFEELKIPEESDVAENTSDDLLEEPSKVPRRPNVKERTKRVPKPRKVTTTRKTAEAKKSIADQKPTTARRVAETKKVKSITKTTRKIIASPIRGRETAGPATVTRRITRSMTKGVAARVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF06</accession>
    <name>A0A2R6QF06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000343">
        <property type="protein sequence ID" value="PSS07202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6QF06"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000160">
        <property type="entry name" value="Signal transducer, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="1197"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1102"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1254"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="899"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="979"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="807"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1120"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS07202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1474" mass="162267" checksum="8DC969FB05204334" modified="2018-06-20" version="1">MADRSGGSLLQTDTPVITEDRVCPGCKGSVMSKDGGVVVAFGQSLFHVDCFKCAKCNNQVTADTNLLLLSDGSPVCANCSYCCNVCEQPILDEAIMTGNDSYHAHCFKCKVCKKRIEELVFAKTSQGIYCMDCHSERVARSRRHHERREKERKEREKERRTAEVVPTTNAGGSARAGESSYKGPANETSPPASDPGVPYASPQNNASLSSRQNGVITSGQPTTPRSSDFGSLGTRPLMTQRGSSSSSVREDHHNALNSAQSSTPRPRSPSVVHGPSPNQDHMRSYTTPISNMNTLGVTSDDKNLPLHKRKSFDDRPLNTVATDEVATNATTNGQSVLLIPDGSIVTRKEKRRSINPGIAMSFNNIPPAVPQNGSPTSSPSTPSQSNTNRSDTPPVQGRDYSRVSSPLREQFPMEVTMSPPTLAKDTLDGPGSNPPYLTLESSNTTAQDKHINGRSRSASSSGYPNHADSHITIPEHRERSRSPMRPSITLDRVPVRTSSRTDHRNETTPPIHGSDSGHRTPQLTGQGRMSPSLNVPNGTPPLLRHRSFDDRQRLSTSSLGQSIELPARQDSCPTSPSHRVDVPHGIESGTDTEAEGEEEYSAQNETVHDSLPPLPPPKEGKGAKVGTRPPQLKLDTSHVEEHDTADTSNLDSEDLSEDFSHEEPIRSTSHATFIAPALPPIRFSMGGADFSDLLRSVGGQDSLRYLDQLAEGKESKLKVDITPPPSVGSDTTVTGSNASMDATPVKRRDLSNHSAADLTVRQDSNSRSRTPSPSPRPSMEFRKTSIDNSSDSSHRTNSSRPSAELSAMERARSFSDTKGLRPSLDGRPRQRERFDSNASLGPTRITVTSPENSTSKLMRSDTSELVRLRLQEALADTSGRGSTHVKLDVEFVGAIMTLLEQRKEEYDDMKRRLDGMKRTSQQYMDGLTVAQTEYDRELKARRDAEAEVTRLRVLLSGQAVRLTAISGETRRHEAQKLHSQELSQSLSSLERDLAKLQVERDMTLAEVEELSASKSSPILSNDDDSAIKLSRALSVRFDNIKNQYQHELLPLTTQRETLLRELSDLRVSRDAFLEETTMLNARNEELAQLNAQYVRRVEAATPDSLPQLNKRSDSLDRSRPSNLSSSVTSSTVAFSDESSHSNFVKVSKPDNSETPAPQVLPRKFMGIWSGTRAQSQAPKESLAVNGTEANKGKPRAEHSFQQISVLRVARCDHCGDKMWGSQLRCSNCNVAVHIRCVHQVHLACSQQQNQGRDEPLASSLTSAGPSMFGRDLSDQVRSDSKEEQRLIPVIVEKCIDAVDVLALDYEGIYRKTGGSGQSKIITQLFERGDYASFDLRDNDRFNDICSVTSVLKTYFRSLPDPLLTYALHEQFIAASTMKDPAMKSSALTELVAELPREHYHTTRALMLHLHRIYERSDRNLMHARNLGVVFGPTLMRSRDPNAEFTDMAGKALTVEWLVENAPTVFEQFDALDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3Y1</accession>
    <name>A0A2R6R3Y1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3Y1"/>
    <dbReference type="STRING" id="98765.A0A2R6R3Y1"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="55"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS19957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="234" mass="26651" checksum="1B1144D147CC6805" modified="2018-06-20" version="1">MSEKPSSSSTPGDKTPTPSASGNGSVEIDKLLSREANAFQRELEVERILVAFKLNPYEILDIDESATPEEIKRKYRQLSLFIHPDKTPHARAPDAFDLLKKAESELSDKPKREELDAIIKQARLLLLKDLDLPITTPDNDSKLKALTPPWKQQLRAKSKELLIDEEVRRRKAVKMNLANEGLEARKKEEEVASRKRKAEEDANWEANREQRVGSWRTFSNSNKKKKKSKVAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3Z3</accession>
    <name>A0A2R6R3Z3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3125</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3Z3"/>
    <dbReference type="STRING" id="98765.A0A2R6R3Z3"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="819"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS19952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1169" mass="129767" checksum="CBA84E869FDDE75C" modified="2018-06-20" version="1">MAETSTAVLDKKRDKYRAQLDAALKDDEDPLAAYGQFIKWTIDHYPGDLIAQSGLLELLEEATRQFKSDPQYKGDLRYLKLWSLYASYVETPTTIYKFLLANDIGTVYAQLYEEYASALEKGGRRADAEKIFLNGIKRRARPIERLKKNYAEFQSRASNPLPRTRPNTLSWKDVSPAVHALRKDPLKNYSKPTKSTSSPAEASGSNTFKAPSSSSSSMSHLKVNPKTLHDRYAPMLAPAAPGKRPEKLCFNLSLLFTEDGTEYSAQEVRARSMGLLGKKWAPPPPSELTRNVRVSFNDDGSKDSRNTTRRGLNVGFSEPTVTLATKEALADVFGMYNSPEKSMRFGTVAGSKHAPVRRIEPIAPLSLQAAFRAVAKDNGPDESKTPTAFRPYVDENANRKENADRAPPPRFQIFQDDEPDAAIKPTSHTPEPSRRALSAKEPLASFPPSKSNENAAAPSLKSSTSVPKRVPEERKVLSRVFTPASDKALFKQDVFSDDQHGDSGAKLRPFADPQPPAPVFKVFSRPPVQAESAPPPPLRLEQGAAFTPFVDEGLSSSRNENVVPPSRPILGDRTPLQSFSTPSTSTDEDLPVSEQFRHEPEVGEEYYDTSTDQSSDIDDQPDMASHVPLPEDEGIYEENSMYDDDDGQPHQVPLGGRFGQFNVMTPITERTLEWTSTRDIGMPNDGHPTGKAFLDQDALESAEQLAAELREPETDDEDEDAVFQVEERTGTLSLSDVLAAASSFNPPNPCNPFEGSIISKLLSFIPSDTAFHDLRNQESNQLDVLQKFAKKKVRRASGSSSRGGQDDEALQIELSGRPYSVLDKLGEGGFGAVFEAIDVGALLQKRKGRAGNDDEEELSDEDEDDIPKVALKIVKPRGLWEFHVLRRIHTTFPPHLKRSIITPETLYAYRDESFLVLELCKQGTLLDIVNRAPQAGITQQGACLDELLVMFFAIELMRLLEGMHNAGFIHGDVKIDNCLLRLEDVPGPASAWSSVYQPSGEGGWSFKGIKMIDFGRTIETRLFPVGQRFVGDWPTDARDCLEMREGKAWTYQTDYFGLAGIIYCMLYGKYIEASSVTEVSTSGDSPTRYKLATPFKRYWQGDLWTRLFDVLLNPTLIRADGQLPLTVELEALRVEMETWLQANCNRASNSLKGLLKKISLSLLGGKDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIE3</accession>
    <name>A0A2R6RIE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIE3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9342" checksum="962DA7B931119900" modified="2018-06-20" version="1">MDGLITDKQPYLAEDVEELLDEGTTVKVCPAKEVVTPDCVASVIAGPPTDVTSTIGTPFDAIRSGQYPQNRPSYRRIAHSLIIVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RII0</accession>
    <name>A0A2R6RII0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000255">
        <property type="protein sequence ID" value="PSS29808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RII0"/>
    <dbReference type="OrthoDB" id="2758168at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="316" mass="36142" checksum="2EE21E9015AD179C" modified="2018-06-20" version="1">MSDVLDKSMIARPQAGAHQNSSVSSLHPKLITRECYLDFSHARRPHVYYGTATYSNLVDYGRVHQQQYRFPEGTHGFLYYHSPEWAPRLAGQLRFRITSSPNPASFSSGTDLKWHGIPWQRPLLALSRLRDFDAMEDILLRDGLVSKDTLLACDKSATLRSGVYGSSRLIYAFGQPFHMKLGWVFKLCVINTSGDKESTVDVLWWLPRIDVRKPMYPNGSAICCFELSKLPEHEGTRSIVIRVLKVVEPIIRTPQDVSDLHLPEIVEGGLLMKNMTEVIRYEVPEDEKRIHVLDKWGLRYLKEYPEAVGSFWPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLU5</accession>
    <name>A0A2R6RLU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000225">
        <property type="protein sequence ID" value="PSS31000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLU5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="10435" checksum="99DF32C8E42021E9" modified="2018-06-20" version="1" fragment="single">QQPVPPGLPINAYNPGWYNQLAEWDQEDLRIAQDFIGGYNASQLSPPIIFGNRDWKAFAVVAYIYEFVLGQGNEGCWYPLVLNENQIYVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM45</accession>
    <name>A0A2R6RM45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM45"/>
    <dbReference type="STRING" id="98765.A0A2R6RM45"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS31082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="21573" checksum="1D3FFFB40CB936D7" modified="2018-06-20" version="1">MSKIQYQRQMPQLTAISTTNTSSRYNTPASPSGRARNTPSLQASLPPTQVIPRLYVSDLSAAESPSVLAEYGITHIVSAMRGTVAVPASASHICRLQVPLTDSPFDELARYLPQTTAFIAEALQNPRACVLVHCVQGVSRSASIVCAYLVQAYGYSPAQAVQYVKSRRPYAEPNPGFITQLGEYAESLRPSTATVGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPV4</accession>
    <name>A0A2R6RPV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000201">
        <property type="protein sequence ID" value="PSS32058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPV4"/>
    <dbReference type="STRING" id="98765.A0A2R6RPV4"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS32058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="261" mass="29121" checksum="E83E8869CDCE9F43" modified="2018-06-20" version="1">MTPHHRLQSYYGYSFESYCTSSSPNGQESQIEATQHAKGWGGDVDTNVQWCSIVKTKLGNDRLVIGGEVDCVREKYTGKPDTFVELKTSLTIRNSQDEARFEKKLLKFYFQSFLLGVPEIVVGFRKPSGQLTTLQSFQTIQLPRLVRGKPGAWDPSICLAWGEEFITFIKSIVSSQSAPAEDLSSPDSKVWRVKFTPGLGVSVYLLDEAGVKEVEAGEERIGFLPAWYLDDLKAKPAQPIRPTSTPTVRPDLPSVVQGWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ10</accession>
    <name>A0A2R6RQ10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2147</name>
        <name evidence="3" type="ORF">PHLCEN_2v4978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000198">
        <property type="protein sequence ID" value="PSS32106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ10"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ10"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036321523" evidence="2">
        <location>
            <begin position="19"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS32106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="608" mass="69414" checksum="E65D526285E9EC2B" modified="2018-06-20" version="1">MLKGSLVAILCGALAVAGLGPRNEYRPYEVENEYPTAERHQWAAHINSPQWLDDHPKRPPLPPHPHVPWHHPPKDPKADTKTVYQALSEDSSITFFAVPDRALHPPKRPRKRRHSKGFNFQDEDMDPFHNSVVAELASTTDEIELFSILEGFIVYQLLDDDDYDNEKKRKIIKKILTAVLSYHILLEKLPAAELAKNATYPTSLKLDDGSLDSEPLRLRVSSKVKLFHPTVNVNLYATITHPDVEAENDWTHDASDNLSPPSYEQEIDSYRYLQAISDEYETQFKTELRGERSFDFQMPNAPVEPITKCREERSMEWCTRMDRLHPQLNHEICNHRDDGLGRGWVCNNRDRGFDRSRIPGCNPLPRPEQEGHGPPMRPPQFTPEFWEQIPLPLPCGPVNLPHPAPFPPPPFCGQCQTPPPRSPFHAQFSSPPQAQSPPPPPWDLPSPPVHFPQPPKFPESGRDRTDPHSPQPPPHQPPPGSPPGPEKPVHHFPKPVYSVDVTLPTLLKDHSLKIHVAQFHSILPHGGYVTKVSVNGQWVILPDVVSRNGAIHVVTKLIRPFRRHGKEGEKGIEDEFKFMSATDYDDYEGEETEWEDWEEWLPQWANEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVN8</accession>
    <name>A0A2R6RVN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000158">
        <property type="protein sequence ID" value="PSS34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVN8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="10535" checksum="52AD108DAC841859" modified="2018-06-20" version="1" fragment="single">GKLRAQSPPTLSEPHQASSTVQDQPKARVKPLTNMPTVEPTLDASSSSKTRKSSPVKARTISPILPAPSSSRTRAPSPPRTPSKVQRSQSEAQPSRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVX6</accession>
    <name>A0A2R6RVX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000149">
        <property type="protein sequence ID" value="PSS34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVX6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="7146" checksum="7217C39E2E5BFC56" modified="2018-06-20" version="1">MVRIPPCPIVHNEWTGIWYFKTILSSGVQVQKDENALVRLNTGIILEDLRCPRMGRVALRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZK2</accession>
    <name>A0A2R6RZK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RZK2"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="273"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS35458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1360" mass="153522" checksum="D4FBF55812CF7F1C" modified="2018-06-20" version="1">MPLFVSPAAIIYSSSSHDATTFVQAVTQYLCLCLSRNAVSPVLQVFEISVEIFWRVISGMRTKLKKEIEVLLHEIFIPILEMKTSTLKQKAVILGMLHRLCQDPQALVEIYLNYDCDSEAADNIYEHFINIVSKLGSSPITSIPPKGTEPTNPSQQPSSKTNPNAVPPSLSTTALSVPGSLDTSGLGLTEQQLRRQSLECLVAVLKSLVAWGTANTAQVESPGDQITRTIPIEDIREEVVTPDTSFDRLSAMPSAGETSRQPTPDQIPDDPSRFESAKQKKTTLLEGIKKFNFKPKRGINFFLETGFIPSSTPRDIARFLLETDGLSKAMIGEYLGEGDEANVATMHAFVDLMDFDGLPFVDALRTFLQAFRLPGEAQKIDRYMLKFAERYIAGNPQTEFANADTAYILAYSTILLNTDAHNPQVKNRMTKLDFKKNNRGINDGSDLSEELLSSIYDEIVNNEIRMKDEVETVPVLAPAPGIANALANVGRDRQREAYLLQSNNMAAKSELMFRSLLRTQRKGSKSGEQYFSASHFVHVKPMFEVAWIPFLAGLSGPLQETDDLEVVELCLDGFKSAIRIVCFFDLELERNAFVTTLAKFTFLNNLGEMKTKNMEAIKALLDIAVTEGNNLKGSWREVLTCVSQLEHMQLISSGVDLPDNKKGRARKVPTEELANESRSTHITVAADMVFSLSHYLSGTAIVDFVRALCHVSWEEIQSSGMSQHPRLFSLQKLVEISYYNMNRIRLEWSALWDILGEHFNQVCCHNNPHVAFFALDDLRQLAMRFLEKEELPHFKFQKDFLRPFEFTMIHNSNPDVRDMVLQCLQQMVQARVANMRSGWRTMFGVFAAASKVPTERIASSAFEIVMRLNKEHFVAIVRHGSFADLTVCVTDFCKVSKYQKISLLAIAMLRGVIPVMLECPECGFSPTAMEKATHADDPMVKFWFPVLFGFYDVIMNGEDLEVRRLALDSLFSTLKTYGSTFPVDFWDTVCQELLFPMFAVLKSSQDLSRFSTQEDMSVWLSTTMIQALRNLIDLYTFYFETLERFMDGLLDLLCVCICQENDTLARIGTSCLQQLLESNVKKLSPKRWERVASTFVKLFRTTTPHQLFDESLRVEVDGSTSDIPDALESNGQAIVPAPLSPNGEQKPGAKVSLSDRRRIFKQIIVKCVLQLLLIETTNDLLRNDEVYSTIPPDHLLRLMGVLDHSYQFARMFNEDKDLRTGLWKVGFMKHLPNLLKQESSSAATLVHILLRMYYDPRPEHQAARPQVAERLLPLGLGVFQDFVRLRVDTQAKNIAAWTPVVAETLQGFVRFDDKAFARYLPAIYPLATELLSRDMAPEIRQGLREYFTRVGYIQGIIEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZL2</accession>
    <name>A0A2R6RZL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZL2"/>
    <dbReference type="OrthoDB" id="2355659at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="345" mass="38299" checksum="412543F70E43B3FC" modified="2018-06-20" version="1">MPKRLLRSISLVASLGGALLNVALAVRVLASWRSLRWDLDSEADALRVDAVKLVWGLLALYFAAAATASTIGFVGIARNKLSYVRFFRDYSIADFTFMLVSAVGVSYASFSSITLKSEVCEELGRQPELMRDMAESGLNLENCEYWFERAVVAVLGIILVFVVVRTNLDMCDFPSKLHFVIALSKYHSQLRRDHQGSGGRYIHGSGVRTSQATKIDSMQRIYLLPTPTSPTSMSFNHHKSSNDSSSVEDVVVYAPVPLGRLSVDEAKEMHATEAWIPTPTTATFSASSKERSHRHHHRHHSHSTVGAGAGGRAHRHRRRSVSVLSPYKDEVTEPLLEEKEEDVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZR1</accession>
    <name>A0A2R6RZR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZR1"/>
    <dbReference type="STRING" id="98765.A0A2R6RZR1"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="432" mass="46446" checksum="FC97578F326DC5A1" modified="2018-06-20" version="1">MAIHFLLQRLPKLTHLSLTGIPSFRQKELQQFCRDPPPDFNSSQRAAFCVYSGKGVSDLRGFLTELFNAMNDETVQSGTEDDEESEGTYRARYAERMDISNGGYDDDDEEEEEEEEDQQDSMQDQIPQSSRNVSVVRGGYSGMHDIGPTDAPFDPTPSDLSMTRERGHGPSSRIGIDASSNAQDISSATPTVAAGPSHRSRGFGHQPLVEASISPTPSDAASNRSGATNHSTGTAFFRNYMDAAPSTRAGVITPDLVFAEIGHGRGTGPANGSGSVRLSDSVVVVSAPHQGSYTTIPTDPSSYPTLSSSRTLQGEVHRSNGHGSILADASNSYTRSPPRSDIAWTEMENEDVSRSLSASPTTRELQESVQSALGQQQFADGRDIDGRGRSVKRSLRNTINAAEQYFFGRGAGGSTHDATAGPSHNRNSNHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3J8</accession>
    <name>A0A2R6S3J8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3J8"/>
    <dbReference type="STRING" id="98765.A0A2R6S3J8"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22418" checksum="1E973D80101F781E" modified="2018-06-20" version="1">MPYQGYDEDLISLLPPIHTVDGLIDYYFEYCNWIYRHVNQQALLRSWGRFKSGNGGDRVVLACVCILILLAVRYLPNGHALLASLPGNSDELETRYYGVMREALLRHNRDLRRDGLGKGYTLDLVELLLVRSHYLTFAKEDPEETWSVKGQLVNIGTAMGLHKDPGDTRFSRDEAERRRWAWWHIILLERQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3P0</accession>
    <name>A0A2R6S3P0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3P0"/>
    <dbReference type="STRING" id="98765.A0A2R6S3P0"/>
    <dbReference type="OrthoDB" id="3256495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="750" mass="81678" checksum="DB6C3E90914A06F6" modified="2018-06-20" version="1">MSSSEHNYTSLSELESLSDSDWLDIASSRASEDEDSAAEFDDSDREDADGRPVSRRSFNSIASSRGGVVEGWEGLIEEEIPLPISDSAADYLSLSVAEGTHVPRPSSPPAVEEDPEDERVKAALDQSMMSTLSSSRSNSLANSLQTSLVHSTRALRLSFPDPTTSRLESLNTSFEKLSSSEADLPAPDIDEEFPPFTDEPVADPGQILTPEVSDDDAREIKCDSVKSIAKPDFYVVLYGSSPMAKYEFIDMLLEKWAVSMGLVSSQKVSRTHRMLIRHFDSQGSHVCKSSRRTVCVLDKTGLDHSRTIIEHDCPSLAIIFLPSFSDISLFDHTLYLPVMMSSPPSLVDFLGITDYFLEAEQQWQALAVPTHKLTVLSMRSSPVVEQETLENAKPSHLQHALRPMFSASSLKKTMPKVSAHAITLLAVLSMVLGYVVHGSLQSSAIGHTQEHGVTSPLWGLLRPVTSVANRSASASLLTTTSSTSALTASSLKDLEVVVFNSATLTFASSLSIARPVSSASSTNPGASRGADALAECDCGCGMLTWPGKTMGTDLILSQTEASSALSTFTGSSNSVSLIAHHPHGKGKAKENATPSDPSLYALSTRIVTSLSEYFDFCAAKKTAHKDVEELIDALDQLVHAIGRQTMMFWEQSKGTVSLLQSGLKQRNHHAQDRARQMREAGVRWISSVGTRIRGRAEVARDNAKSIKKMMGDPKAEKALRRWRGETLQLPGVKRISERRRARRARRGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S517</accession>
    <name>A0A2R6S517_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S517"/>
    <dbReference type="STRING" id="98765.A0A2R6S517"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="66"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="288"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="495" mass="53321" checksum="28932E6B0A441D2A" modified="2018-06-20" version="1">MAPAASRGAIRRLINAAQHTACPCHGCRAGGSHNALAAINQMRRFATPVDALPVEKEYAFEVAASNLRFGEGVTREVGMDLKNMKATKVGVFTDPNVRNLPPMKMAIASLESQADLPFEVYDRVVTEPTEASWRDAIAWARSHDCSHFLAVGGGSVIDTAKAANLFTAYKDADLFDFINAPVGKGRPIENILRPLIAIPTTAGTGSETTGTAILDITSMSFKTGIANRAMKPVLGIVDTLNTRTCSRELHISAGLDVLFHSLESYTAIPYTERTPRPSNPILRPAYQGSNPVADIFSMWALRTTVEMLPRVAKNQDDYEAMKQMLLASSFAGIGFGNAGVHLCHGISYPISGLNKKGPKYKHPGYLVDHPIVPHGISVALTGPAVFQFTAPSSPSRHREALAIFNRTSLADPSITSIPDSEIGAHLYEAIARFLDGINVPRGLKAIGYGQADVAKLVEGTLPQRRVLDLAPGVGDVVGEDGREHLTQIIERSMEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S573</accession>
    <name>A0A2R6S573_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S573"/>
    <dbReference type="STRING" id="98765.A0A2R6S573"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015351415" evidence="3">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="263" mass="27244" checksum="9976EBC36E42BC91" modified="2018-06-20" version="1">MLAQFSFLWAIVLSLSLCSDVVVADSHGSQRRHHGANRLERDHSLSKRFDNARLSYYEAGQGACGAMNSDSDFIVALNAEQYAGGSHCFETITISYNGKTTQAQIADECPGCPYGGLDLTPGLFSFFASEDAGIIYGEWDFGSGASPTPKPTPTPTPTPTPIIVWTPTSTWSPPPPTTTKHSTSSPPPPSSSSSSPSSSSTPASSSASPTSSAPPSTSQPSTSSAAPTSSSVAPVPTPTGNLEGLQLAFVQLSALIVASEQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S581</accession>
    <name>A0A2R6S581_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000044">
        <property type="protein sequence ID" value="PSS37412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S581"/>
    <dbReference type="STRING" id="98765.A0A2R6S581"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="567" mass="60995" checksum="A119F02633CE851A" modified="2018-06-20" version="1">MFQRDPRAGAFLGGDRISGQDIRDQNGAQFSTWSIDHQSLKFCGSVLAAQSIANIVKSSLGPLGLDKMLVDNIGEVTISNDGATILSLLAVENPAGRVFVDLAQKQDREVGDGTTSVVIIAAELLRRANELVKQKIHPTTIITGYRLACREACKFMQDQLSVKVDALGKEALINAAKTSMSSKIIGGDDDLFAPMAVEAMLAVKTVNNRGDIKYPVKAVNVLKAHGRSARESLFVKGYALNCTVASQAMKTRITNAKIACLDINLQKARMQLGVQILVDDPSQLEDIRRRESEITLERIRKILAAGANVVLTTKGIDDLCLKEFVEAGAMAVRRCRKEDLRRIAKATGGTLISSLANLEGDESFEASYLGSAEEVVQERISDDELILIKGTKVVNSSSIVLRGANDYMLDEMERALHDTLSVIKRTLESGSVVPGGGAVEAALSIYLENFATTLGSREQLAIAEFANALLIIPKTLAVNAAKDSTDLVAKLRAYHNAAQNAPAGDPKKALMRYGLDLLNGEVRDNVTAGILEPTMSKVRSLKSAFEAAVSLLRIDDAIQCVPGTLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S708</accession>
    <name>A0A2R6S708_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v98</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000008">
        <property type="protein sequence ID" value="PSS38067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S708"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="432"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS38067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="896" mass="100485" checksum="8FF32FB2C99AB672" modified="2018-06-20" version="1">MPEHSPPPGESPPGPEGLPPDKEATKEGRGSTPMRASCEVMRDHKTDSVHPFVQQDLEDTLREVSVDTWIEAVLGVPPDRLNEWATLIKKLGWFRDRTIERALTDYARPAQESGIYKPFARIANQILELAKGALPGVGASYPIADIEVVVNDPISIERIPEHGELGAFRKPDLLFVRGSQKDLSGGNGARVRWVDILAFMEFKLDHKEQLLQTLNTCRDDRGLPTIKSKDVKPSKPKKNTKKPAPKRRPARIVKVALVSSDRGTSGPSSAGSKRSIDDVLDGDTDQLRSSSKKQKTESSNVNVETIRKNVQLQAGGYALELASCTYGTRVFSLGSIVRDDKMSLWYYDASGYVRTEESVSVMKDFEKFAAIMVAFACGEPKHWGALPDIISPPSSTPYPASFPPPSLKGHSLEMVPPDTKEPVKVTLGKPVFTQYGLVGRRTFLYRIKTNTVVAQTPLVIKFSYQVVSRKREQDLVEVARKAGVKHIPKVHMWRDLWKLSDGARAIFHGDKKGVYEDKMLRALVYTRYIPLKALFKTAWHLIPHMADQILDCLHDLRYKSNMLHRDISANNVMFEVRDGAVKFVVIDFDLAAMVDSNGEPLAAPSSKHRTGTLPFMAYELLRDMAKSTSSEHQRIVHRLRHDFESLFYLCLYCLLTMVEVEDAKIKADMTKELRDWEDQTYSSIASSKQYLCTDIENMGTLVLPVPCQVLRPWFYGWVTVFQRADLAMSNYKNQVRLAQWYKDESSSSFDIDTLQGTITRDKIKQSLGFFYDRPLAPEDLQVANIPGLGKKIEAYMDDDEDLAEEDGHVQGQSVVVKKAKPPRKPRSTTKVKKVEVAKKKTVPKTVVASKKTTTAELVGPIRKQTQKPKRGVRTLAAATRSMTTRSMQKGALAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S741</accession>
    <name>A0A2R6S741_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v50</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000003">
        <property type="protein sequence ID" value="PSS38108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S741"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="465"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="940"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS38108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="953" mass="107804" checksum="8B2774FA81BF89F5" modified="2018-06-20" version="1">MPQATRTRQALLPPVQVEEHCPKPPPRPGENTNFVREGTPLVMSLSCLLTVEHTNATVHPYVKQDIACAKSVPYHVWTDAILKLDKRKLKKWVAHIKRHEWRKDPVIQEALIQFCGVSKEIARYEPYEHIINRILELAKDQFGAFDSYPIEDIKITRNDPKYIERIPEQGVLGALRKPDLLFVRGAAVERVLSTKNARFRWSDILTFAELKAESGLLPSLNGWRIQQGLPEIDPNTLKPRVETRKRRPRAKPSLSRPGPTRSSRALRGATAVPPDGDSQVLPSVPKRLARKALRAPVQEDFSLSDASTGSKRARQHDDSESLHITKRSSTGSGAAKSDIVTLDATVQAGGYALEVASCTYGTRLFCLGTVMEDDKLSLWYYDAVGIVRTQETLSIIHDFETFAAVHIGFACCEPSQWGALPPVIRPPSPAYPETFPPQSLRGYTFDTSVQSTGEKVKITLEDPIFSQYSLVGRRTFLYAIKTKSKTLKKPLIAKFSYQVTTRRPEQDFVKIAREAGAGHLPEVHMWEDLWKMSDGVRAAFHEKSDEYEDRVLRALVYTQYFPLKELFSNSGDLIPDMVNQMLDCLHDLRYKANILHRDISCHNVMYEMRGEKVNYILIDFDYATTVNTRGEPQPSTKCKHRTGTLPFMAYELIQDMADRELGNYRAVAHLLRHDYESLFYLALWCAVTMPVMRDQMKKKEIYRLHIREWESGTLRSIASNKKLLCTEMGRTDKIAFPPECEALRPWFRRWNALLATAAMQLEQHRLDAFHDDGYGDPLFDRETVGGTLSRDSIKRALSGKVRRMRLVAADPEETEFDPLFRDHEAKDPAEPEDIQESVGFEGREESHASENDTDDLPRTVLQQSKGRGSSKRGLKTKKDAMTRKVAEAKKAIEKKKPTAAKRVVDTKNLEAMAKTANAGATSTKPSWRARTTPQATATRGMTTRSMAKNSVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S751</accession>
    <name>A0A2R6S751_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v75</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S751"/>
    <dbReference type="STRING" id="98765.A0A2R6S751"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="148" mass="16377" checksum="032A282DF0EE5DF0" modified="2018-06-20" version="1">MTERALYAALAPSPQTSAYLKAVCRTWPDHLWAQVSVVCEEKESSEMARLRESFWEGAGEVEGTTSLDESVDMDAEELEEEEWEKEVVGSLESLADIPVEDGPPANNPYYISQLNIILDRMDSLLDAFAEGLQNGSYDPSSPESVISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE98</accession>
    <name>A0A2R6NE98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE98"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7692" checksum="CE2E2A415C762ACE" modified="2018-06-20" version="1">MDRQFRALFPEIKEEKEAERETENRATGIREKITRTPERDALTVPTSRPDTGDGIGTFTSDKMYVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEC4</accession>
    <name>A0A2R6NEC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001333">
        <property type="protein sequence ID" value="PSR70723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEC4"/>
    <dbReference type="OrthoDB" id="2754197at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="500" mass="57022" checksum="3168535519186244" modified="2018-06-20" version="1">MADDDKRRYKWLKTLKLDLGDSAEATDRLLEILSNAHTLKRLEIRNCHLLDRDERIRQAIASLTTLKEIKLLRMSVISSAHAMLLEMESDVVNLEVSFFSETGNFIDGEAVIGLQKFAHCAISLHLWVAEFIHCPEEIDTSEYPVYPQVKTLVLDNARVDRLQLLTHAFPNLRSLTVINIDNARGPLGEEEPEGVEEVRDINRVDQEEMAWEALDYCYGNVNNLYTLGMISKIQRLDLSRVVIRDEAEIEQLRAVVTDALPQSLVLHVAAEFEMNALRNALFVALDDLLDFTLIVDIVEAPSRDIDPASVVACIDETIEMLFSILQASSIERLVFTMLWPGGMFILPPGSLLRWRGHEVHLAIAQRFRQLEMQYVARQAMEHAPSLRYIVTSFPSFPRSFWKVEVNDEGNRSVKTMNYKEIRDFLTLEDIVIQPNPFMFPYVYCLDVFRTIQPTDEYLRSIITGSGDFQDDGSFESESGSESESESEAEYAAETEGNTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEQ4</accession>
    <name>A0A2R6NEQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001318">
        <property type="protein sequence ID" value="PSR70791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEQ4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="14158" checksum="82D6BE844F909EB2" modified="2018-06-20" version="1">MSRDSLLGKLEAYQHQIYQRLRREYHQRAGPQQPQQGAKWVGSTACVKKAHFRVFARFIDAPQRVESNSDLELPTPNGGYRGFKKHGVEGKLWRLEQADVPPIPYRETSITDEETKAKKYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NER0</accession>
    <name>A0A2R6NER0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NER0"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015325573" evidence="2">
        <location>
            <begin position="17"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="18880" checksum="33CEF355B38F699D" modified="2018-06-20" version="1">MKVLLTLVSFVGGIISHTQIPPLVPLKPTISSLTEVNLRGWSGDGITLPGALDIEYNPSGAECYGLSASSMVSWIKDFSTTYHSTTGVYPVIYTTTDWWTTCTGNSASFASTNPLWVARYASAVGTLPAGWAYVVSLCQGATAKLRHAADMRRFGRTQIPGPTLETKTFLTATLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFA6</accession>
    <name>A0A2R6NFA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFA6"/>
    <dbReference type="STRING" id="98765.A0A2R6NFA6"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="86"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="528" mass="59118" checksum="AB8011C230E22F5E" modified="2018-06-20" version="1">MAYSDSDYEDDEGLGIIYPLSIFFALGIWLVFQRYQSIRNRAVPFRIRTPEQIGPNFQALKIENPSLEAHMLDPNLMPPFSIEGRKYITSYDPATSYHLGTFVADSQGDIENKIRLAVEAQGQWRNSSFADRRKVVRSLKKWLVDNQETCAKVAARDTGKTLLDAALGEILTTCSKMDWLVNWGEYYLKPESRSTNWMLVYKSAKVYYEPLGVVAAIVSWNYPLHNAWSPILAALFAGNGIIVKCSEHVIWSTQWYISAIKECLRVCGQNPELVQLVCCYPDEAEVLTRSPWIRHITFIGSELVGRKVALAATEHLTPVTLELGGKDPAIVMPATDIKQYASIWMRGLFQNAGQNCIGIERLIVHSSQYDEIYSMIVERAKQLRLGTALSQPNDGFIPTVDVGAMISSDRFNDLERVLETAINHGATVDAGGVRWKHPYLEHGSYFSPTVVGNVAPDSELAQREMFAPIATIIKYETLEEAIAIANGTRYGLGASVFGPDQEHCVNKIAKHLQCGMVSINDFAVFYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFL5</accession>
    <name>A0A2R6NFL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001318">
        <property type="protein sequence ID" value="PSR70792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFL5"/>
    <dbReference type="OrthoDB" id="2744824at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="43730" checksum="F5AD5A6A01DB3883" modified="2018-06-20" version="1">MSDILETRRIPYFPAEIMDIIIDLLHTDKATLSSCTLVSRSWLPRSRLHLFTRVQVFGFQTQFQPFIELLTQANGGPRLDPPISTTIKRLRLDGRDDSVFSSPEPLTTSMLKMLLCNLPNLLDLDVRGVILTWVAPGLSDTGDKVALPDLIHLNSLTLDAFTTASKDPSDFVSSLCFFSSIDVLRISSPLYMDIPEDPAAVAAHPSLLTTMPYFPSHLKISSIAVCDGECTPFILALLQKTASVETINNVDVVCRTRVHADALGSFLDNVGARIQNVSVDIVMLFQAASTLVAYASRTVQTVFLDILLDGSYVDLSRFNSVVQNMATEFIWLQSAIKQKSSRLCIRWNGLQRMVKRIEERVRFEEELCRLVQSHLSKLGADGMLSFASDVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFR7</accession>
    <name>A0A2R6NFR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFR7"/>
    <dbReference type="STRING" id="98765.A0A2R6NFR7"/>
    <dbReference type="OrthoDB" id="5401396at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015311898" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="12861" checksum="F1DB240B95B80FA4" modified="2018-06-20" version="1">MQFKLFIALASVLSAVVAAPSHMEERSAEVDGHCYICTDDYWGGDCTNYGFYSGQCTNFPSEFQDDISSIGCDSGWTCNAYLDYNCNNDQSSLPIGNPGYAALGWGNDALSSMQCFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFS1</accession>
    <name>A0A2R6NFS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFS1"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="339" mass="38301" checksum="2672C59E778A3702" modified="2018-06-20" version="1">MDQLTFLDSLLRTTAEQIDFFLENGYVVIKQAFTKEKADAFTKNMWVRLGMDPNDKSTWNQERVHMPPINREKVATFAPKAWEAIKELLGGEDRIDEQASTWGDSFIVNFGTPALEGAPTVEPPNLDNWHVDGDFFIHFLDSPEQALLVIPIFSDIKPRGGGTYIAPDGIDMIAQYLASHPEGVIAENLSLRPSTTTAANPRESPGYWSHLEEVKKCQKFVEVTGEVGDVVLLHPLMLHSASKNNLREPRVITNPPVGLRKPFNLCREDPRDYSLVEKKTLKALGVEKFEFKPTTERRSVVPQRVLRERAMLEAERKRLEQLELENITLITNSVPIAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFU4</accession>
    <name>A0A2R6NFU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v12940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="MLYV02001292">
        <property type="protein sequence ID" value="PSR71181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFU4"/>
    <dbReference type="STRING" id="98765.A0A2R6NFU4"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR71181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="242" mass="27068" checksum="911DB1FF22272501" modified="2018-06-20" version="1">MSDNTQKSLPKERPIFVIVMGVASTGKTTLAKALNKRLGLPYVEGDDLHPKSSIEKMSNGIPLNDADREPWLELIRITAEHMIAEQQAKEQAGTASEKEKKLRKGVMVTCSALKKYYRDIIRGTYKAHELPEHLDPASAEKLPTYFVYIKPEEGVLRERMAKREGHFMKPQMLDSQLATLESPEGEEGVIVVPLDATTDEQVEIALDGLRKMVGELTVDLGAGVTEKEEEVNVPEELRHVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG10</accession>
    <name>A0A2R6NG10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001291">
        <property type="protein sequence ID" value="PSR71198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG10"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF148">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="303" mass="33805" checksum="93E5E27577815ACC" modified="2018-06-20" version="1">MAFYGWPISQCQSLDTPLAVQLKSGIRVLDIRLAVRDSRLIAYHGIYPQKASFQEILSVIHAFLTADQTRKETVVMSIKQEDFTTVPGDVFSKLVLKEITDGPGGKDMWFLDNRIPLLGEARGKVVMFSRFGGDGDGWPGGLEGIGIHPTTWPDSRREGFSWDCKNTLVRTHDWYNIPSFLYIPEKTELATQILLPPPNDPPMPSLAITFFSAASFPLAFPPTIARGFGWPKLGFGVDGVNARVGRWLMEMLSGDNKDSNAGKQPRIRGWALMDFYEDPESAVVPLLVECNFRGRVKGEEGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG17</accession>
    <name>A0A2R6NG17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG17"/>
    <dbReference type="STRING" id="98765.A0A2R6NG17"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="209" mass="23424" checksum="3E51EA7D5B9196A7" modified="2018-06-20" version="1">MSSALAALLTDPAYHDYLAILKGARNGFVYGVKVRFPHALIMAILFGRGDWSSRLRTIFRATKAHALNLAKFVSVYKTLLLVQKRVNGGKERGLDTFIAGLIGGYLVFGDRTAVNEQIVLYVCSRVVASFIPRATSPYNISSNASSAVRPVPPNARYFSVFAALCWGAVMYLFNERGETIQPGMFNSMTYLYRDSDRWNNLRTLLWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGH0</accession>
    <name>A0A2R6NGH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001281">
        <property type="protein sequence ID" value="PSR71490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGH0"/>
    <dbReference type="OrthoDB" id="3264042at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="227" mass="25580" checksum="7B020B29DDEEE6F1" modified="2018-06-20" version="1">MSSLFSVFPPLTSVSHRTARLLYQNRYNAIKRTCGKRKISKRDREILEGRREAEIKGDIPKVSNTIVQKLSAVDPERTPQMVEDEQFLNSECMDLMWSLGRDTDSERLVTLTQNLEGSIKSYRSQAIAYIRTSSGSPNTQIVHAYRRKIAVLHEFLDLHRQGHDAFALASAWGETVYSGRRRASSLSSSSSSTSSTPSIITSNENRRGFTTRISSTFRGTQEPMLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH00</accession>
    <name>A0A2R6NH00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH00"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="279" mass="30964" checksum="F7AF6538C6ECDFCF" modified="2018-06-20" version="1">MANDVAKAQLIDQFMTAVVYGIYLVTLGMTISVLFWGRMGQKRRNWPLIFVMALMFIFATFDVAFGLQHNLDAFIYYTGPGGATAAFEDISNWVNVMKARLIVWRIWSIDKESTRMTSLSTLKGGSSKLARVIRIVVESALLYTTLVLMTTVADVIGSNAIYPLAETVRFSWILPNFEYVDQMYGTQMVVVIGISFNLIIIRVDKGIAVGPGTYVETSPSIPLNLRRGPTHHTTTYGMEVEVDVAVLRDSGDMGRVHGDQCTSDTTKGSITEDATKYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH55</accession>
    <name>A0A2R6NH55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001246">
        <property type="protein sequence ID" value="PSR71726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH55"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6330" checksum="621163948B6C16D5" modified="2018-06-20" version="1">MESECKRRGYMSHFTVLMDSVVYCDNVQQFEGESTTLLVLMLFGIVMAITNSYIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH77</accession>
    <name>A0A2R6NH77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001287">
        <property type="protein sequence ID" value="PSR71352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH77"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015315736" evidence="2">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6114" checksum="4AC750F1036E61BC" modified="2018-06-20" version="1">MKFAIPFVVLVSAVKSVHSHTTVWSVWVNGVDQGSGVGIREPAYNDPPTNDSSSGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHI8</accession>
    <name>A0A2R6NHI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12345</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHI8"/>
    <dbReference type="STRING" id="98765.A0A2R6NHI8"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="261"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR71844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="535" mass="57842" checksum="299D564331C8BC50" modified="2018-06-20" version="1">MSGLADELLADLEGLSEGEEETIEVEQVEEAGPSTSNGVKRSAPSDDEMSEGEGEDDEDDQKQVVGSLVLEGGIKPAEELDAEEVQRMELGGVEDVRKIAKLHGSKRMNDILKEIEKYEASPSTPEQMSLPAHSNPEYNLIVQANNLSVDVDNEILMVHKFIRDHYAAKFPELEQLVQDPQMYIRSVRALGNTEDPTKVNLHGILPSAIVMSVMITATTTNGHPLSEAEWGAVQRACELADNLEEARKKIFMYVSSRMNVLAPNLSAIVGTTTAAKLLGVAGGLSGIAKMPACNVHLLGAQKKITAGFSTATQRRHTGFVFQSELVQTTPPEYQMKVQRTVGAKCALAARMDLERQRRDGSYGDELHDKVEKHIDRLAAPPPSKIVKALPIPNDGPKKRRGGKRARKAKEAYAQTELRKLQNRMVFGEAEEEVGAFDQTKGLGMIGSGKVRAGAGEAKSRAKLSKANKLRTAALTRVAQSSAGGTQTSGTATSLTVTPVQGFELTNRAAAAQRVKEANERWFAGGTFSFIGQKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHX6</accession>
    <name>A0A2R6NHX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001264">
        <property type="protein sequence ID" value="PSR71582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHX6"/>
    <dbReference type="STRING" id="98765.A0A2R6NHX6"/>
    <dbReference type="OrthoDB" id="2506773at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38233" checksum="F0E5F5858BEE7603" modified="2018-06-20" version="1" fragment="single">MSFPRNDPLRLSVNASINSDDFPTEWGTFSETSQLILSLPAGAMAATFDIAAAYRITPVAPQQQNALCIFWRGKVYVDRAVAFGLRSSAGVFGALADMLVAIYRASGFGPLTKWVDDFLVIRLPGQEWTEDEFIELTARLGVPWGRDKTRPLAMRQQYIGFIWDLTKKLVSLPIDKLSSVFSLLDRWLEPKAVFTSREAAHLHGKLVHVSCIFPLIRPFLPSISRFASSFLSARSSLHPSGGMQADLTWIQYIMRKLPNEMPLSSPEPLDIEWWGDASTSFGIGVAVGTFWGVWRWTTEMRVGPRQEYDIGWAEAVAVELGLHMAIYHGLIASRPTNRNAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI14</accession>
    <name>A0A2R6NI14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI14"/>
    <dbReference type="STRING" id="98765.A0A2R6NI14"/>
    <dbReference type="OrthoDB" id="3209295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="552" mass="62618" checksum="80049A22CC29ED96" modified="2018-06-20" version="1">MRLPPEVLASIFSLISAHRRTIAACEQKDVEFPSLNVCISLSQVSRYFREVAISTPSLWTSIFLNSRKGAPPERVELLQALLLRSSTSPLDVHMGDLTRGINDPAFLTAISHLPRIRELHFYEQREYVEPHELSPLLNPAPLLEALVLSQYAKGSQDDSLLTLFDGCAPKLTSLVLSGYPRYSGNKFRNLRQLSLTQIMYRTLEDVKGFLGLLDASPTLEDVLFRNMFFPTLPDLSRRSNMPRLKRLITELQHSSERFILSCLSLYPGVAYDCSPYHTGKSLQATFPRDKSHLGDLLHPTTVELDFHDDFCRVTAASQSSIFRAALHKNDPYLPPRSQEYLSMEDLASTFFSGGSVRELWLQFKCVDQRPHFLEARSCWYPLLLPAATLTKLVLIYRPSHCEDHPGLALARSSFLQLLALIFVESKSPVCPLLNEIHIYGLPEDIRESFFAMVKSRKKCGHPIPIVYLYQVRGEAGFGNTSAEDGFKSWRDGLDYLRPFVGEVVLEVVEKYPCIQLPQVCTSTGEGRLAWPRWVDSVDESQINTNWFHSSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI75</accession>
    <name>A0A2R6NI75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal L1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v12446</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the universal ribosomal protein uL1 family. Highly divergent.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001256">
        <property type="protein sequence ID" value="PSR71672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI75"/>
    <dbReference type="STRING" id="98765.A0A2R6NI75"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000004">
        <property type="entry name" value="Ribosomal L1 domain-containing 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR71672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="643" mass="69338" checksum="8EC42B785A4075D2" modified="2018-06-20" version="1">MSKTELVDEHVSAQQCKLAVDALLQHEVKRQEKKQQTELLPGKEQNVWLVVTVKQMHPEKKLKPHRIPIKYPLVDPRTSSVCLITKDPQREYKDLLEAEKIRFISRVVGITKLKGKFKPFEARRLWLKENDLFLADERVVPLLPSLLGSKFFAAKKQPIPVSLTKKNLKEELERAISSTYFHQNQGTCSSIKIGTISQSAEHVLTNLKIALPAVVKVIKGNWDNVQSLHIKTNSSTSLPIWTCNLGSEEGGRWNGLMDAPVSEAEDEDEDEEMVSDVPTPKAASKSKKRTTDDEGDKPSKKAKASLDHPADIKMNTDPPSEIVTRSKKRKATAPVEEVVVSSATAEFAPPDATGKKKKRKQQAAKDEVVSSSAPSAQPVEQPVVPADLPTATSESELEKPLKRKKRKSQAIIEASSAEPAPTTSDTQASTTVAPVTPSVSLRQRKKRNRASATDFFDDAQATPDQVVPPLNTPATGLQTPVPSGKKRTKAKAAVLSTPVSGAIGKLADEAGTSASPSAVNGAAQLASKKKALGSGHDGKDAAPATSATSSVVGALSKPLVEASAESGVADGGERKKKRKQRKSQEDAASADAVQAPPSKVDSAVPTLEEVKQKRSASTVEKRKDKPRKAKRSAKDALIGKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ65</accession>
    <name>A0A2R6NJ65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ65"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ65"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="50"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="425" mass="46487" checksum="22CFCDE7450B0884" modified="2018-06-20" version="1">MQVISRPLTRSAPRNLRRAAALSTWSAVPAGPPDPILGVTEAFKADKDPRKINLGVGAYRDDNGKPYVLGSVKKAEAFLESTNPDKEYLPITGLPEFTKAAAKLAYGADSTPLTTNSVAVTQSISGTGALRIGGAFLSRFYPHSKTIYLPNPSWGNHTPIFRDSGLEVKTYRYFDKKTVGLDFAGLKEDLKSMPVGSIVLLHACAHNPTGVDPTPEQWTEISDLIQEKQLFPFFDMAYQGFASGNTTRDAFAVRHFVSSGQQIALSQSFAKNMGLYGERVGAFSLVTADPEEKARVESQLKIVVRPMYSNPPLHGARIASTILTKEELYKEWEGEVKLMADRIISMRDRLYDNLVSLGTPGEWGHIKSQIGMFSFTGLTQPQTKALAEKAHIYLTADGRISMAGLNGNNIDYFSESVSKVVKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJI5</accession>
    <name>A0A2R6NJI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001156">
        <property type="protein sequence ID" value="PSR72537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJI5"/>
    <dbReference type="STRING" id="98765.A0A2R6NJI5"/>
    <dbReference type="OrthoDB" id="2751948at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="284" mass="32782" checksum="83AC5DEDF8F563F0" modified="2018-06-20" version="1">MAPHVQTTNTQRRDHDHRQQPIPCTTPGPPRTRERSETPDAPEEENKKIPRSGALTKFQMLWRVTTRSKSIHLSEDSSEDTELDDMTPDERDVILTQYKKIMQLIPSINEDAQSYREDPDALCDVIRYIQRHAADGRSDDLGTLKPKILGYLPLKAPNAPSLESLTLSKGKRGWAHHQTARLLCPRSLVEKFDPDPDRSIHWSANGNKKGVWTIRRWSSIKDKDIQDDQGHARAHFLICGQDSWDPQDGMFSLPNFYQAIMDLFDDPTNPWYIDTLAWWNKYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJW6</accession>
    <name>A0A2R6NJW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001152">
        <property type="protein sequence ID" value="PSR72601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJW6"/>
    <dbReference type="STRING" id="98765.A0A2R6NJW6"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="89740" checksum="4BD380C43705F004" modified="2018-06-20" version="1">MPPRLNKRQLRELEELQHLEATGSPASEQVEEEEEEEPSDRGVTSGFAALVSAEGDDESEDDDSSRPSKTKKKKKKKKASATTPSIVPTPHASVQVMPTPHTPEVGSPSGISKKEKKALKKQKAKAAKDDTDDLDKALAELSLKYPELKRPAADASSIKASSTFFSLLSVSLPHLDSEAEMRKFFGSKVVSASKASGSGTSSGRRPAIAAKSNLTRPQNTWWPASHRQGLTMRGLTDEEMEERNQRHQWVGSMDEKVWTVEYSRKYKGMTKTFMQMVMSGDPEGLFQILRSFPYHADTLLQLSEVYHHREEHSTAADFIDRSLFTYERAFVGSLSFSTGSNRLDFDRVENRPFFLAIHRQVSDLHRRGCVRTAFEFARLLYSLDPSVDPHGALLHLDFLAIKAGMTQWLLDLWDVQCRFGENACKGRSHVRALPGWAYARALALFVQEEARDDEEHKLSTNALIEAVRAFPSVVPLLADKADISLSSEVRSHQAFRIHTDASTLRKQSDSILHLLSHLYAQRSFSLWKVKSRSIWFATTVNSTPLPSKSSMPFSPTPFSPSPSLFDTLYTAPSLASSVYRHVVVLESVTRAGRLFGFLPASVTSGKQLACDPLPPPTRVSEYDGEFFQGAEDPLAAHPRGRRENQRMLDRLVPDPVFRRQLQDFFEANPHFAQRFPGGIVEFAQIAGQMPEEILEDLMIEVAAGQGGRDMPGQMPGQDLFGDVQLGVAPPEEIPRQPQAIDHDDEGDLDGESEDDDEMNEVAPLPVRILRNVLNRFWGNNVATNAESSDDDDDPGEELRDEEGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJZ0</accession>
    <name>A0A2R6NJZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001141">
        <property type="protein sequence ID" value="PSR72677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJZ0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="177" mass="20317" checksum="8B272575BE496049" modified="2018-06-20" version="1">MTSVFNRSQLPVKWDILRYIDVLESFQNLQDLKLWRGTYVRGWAGMELIGKHLGDRLVRLEVVLNTLLPPVKKHNKPPPVVYVFSKLTNLTLTIRWTSTKQFPDVFPIQIPSLSSSQFPVLASLTIKFLAGPSPDLINHFLLQSHLPSLKIFRITDRHRFTSQAAFRAFCTRHGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK53</accession>
    <name>A0A2R6NK53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001141">
        <property type="protein sequence ID" value="PSR72681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK53"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8293" checksum="C56279F1A461AAA7" modified="2018-06-20" version="1">MHHEYVVSNTHQAQVANRSECPPSQATHLRCVRAHYVGVFPNLFPASVCCPSTVSEPRQSTLDWITLAVYLRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKF8</accession>
    <name>A0A2R6NKF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v11273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001127">
        <property type="protein sequence ID" value="PSR72860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKF8"/>
    <dbReference type="STRING" id="98765.A0A2R6NKF8"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="217"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR72860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="654" mass="73585" checksum="9A1207EF16A4020B" modified="2018-06-20" version="1">MAENFQAPVNKTAHAFDKGRLESMLSTRFFYAPAFEIYRGVAGLYDYGPPGSSLQANILAEWRKHFIIEEHMLELDTTILTPATVFETSGHVARFADWMVKDIKTGDVLRADHLVKNVLEARIAGDKEARGQAVRVVEDEKDKKKKKAKPVKLLDEVVAEYERILAQLDNYSGPELGQLLRDHNITNPDTGNAVSEPQLFNLMFASSIGPTGQHPGYLRPETAQGHFLNFSRLLEFNNRRVPFASAQIGRSFRNEISPRAGLLRVREFTMAEIEHYVDPENKRHERFHEVRDVELDLLDRHVQSSGHTTITRISIGEAVDKGIVANETLGYFLVRIYLFLIKIGINPKRLRFRQHMSNEMAHYATDCWDAEIENSTGWTECVGCADRAAYDLTVHSAKTGHPLVVQEELKEPIVTEKLVVGYDRKTLGKTLGKGFAIIQSVVGGMNEAELLNLKGQLAQGSAVIVSPEGQQFKLTPDTLSIEWKTFTQSVREYTPNVIEPSFGIGRILYTLLEHSFWSREQDVDRGVLSLPPIIAPTKVLIVPLSPRDEFKPLVREVSAKLRKAGVFSNVDDSNQTIGKRYARNDELGTPFGLTIDFASISKRTMTLRERDTTIQLIGDIDEVIPIVIELVNGSMDWPEACQRLSIYEGVQSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM19</accession>
    <name>A0A2R6NM19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM19"/>
    <dbReference type="STRING" id="98765.A0A2R6NM19"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="58"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="897" mass="96810" checksum="7568FB13370847C2" modified="2018-06-20" version="1">MGVLSREFAEVAHVFQRRITAPQQAGIFVGANPSTYNSGDPFPLWVIQVVMIMAMTQILSLILSRIRQPRVISEVIGGIILGPSIMGRIPGFTNAIFPMLSLPLLNLTSTIGLVLFLFLIGLEIDFRVIKRNARASMLISAFGLIIPLGLGAALGIPIYHQFVDPSINFGLFLLFTAVAIGITAFPVLCRILTELKLLDDTVGVVVLAAGVGNDIIGWVLLALTVALVNASTGLVALWVLLTGVGYTLFLMFPVRMGFRWLARRTGSLENGTPSALMMTVTLLLVFFSAFFTDIIGIHPIFGGFLAGLIIPHENGFAISVVEKLEDPVTLLFLPLYFAFSGLKTNLGLLDNGVTWGYTILICVIAFFSKFLGCAGVAKYCGFSWRESGAIGSLMSCKGLVELIVLNVGLSAGILDTRTFSMFVLHALVLTFVTTPLTLLFYPSKYRTHASALRDNASRASVDGQGVQAERGQETFKTKFAVVLDRVEQLPAVMTLTQLLQSPSPKPTALSSVSKSSIGDEKEPTSPLGLPYVNGEPSLRISVDALRLIELTDRTSAVLKSQSADALVKIDPILSVFRTFGYLNRMMVTTALAVVGYDEFPSYVDNHTRATGSEMVIMPWSSNLASIENNTVEASNAVGSSPIAVATPFDGLFGPKNTAHNPVSAVQTQYFRKMFAECRIDVALFIDRGLPHSVDVQGRQHVFLPFFGGPDDRLALSFVVQLCLNPSTSATVVRFTKVDSNELTPVNSIQDTRKEDIYQVHAVNVQDTVYAQGDTQTRLASDTADNVLWDQYSSSSASAVAGALRRMKFTHEISARPLHSVLECAAKTLANQAQSRPLVVVGRSRRFAVGSHAAELRELLTEHGASANSEVAKTLGDTGASFFAANANASLLILQAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMP3</accession>
    <name>A0A2R6NMP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMP3"/>
    <dbReference type="STRING" id="98765.A0A2R6NMP3"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15325" checksum="A44E2E5C4EC15340" modified="2018-06-20" version="1">MAQTHCHHSLLAKAALPDSVELSFEVKDFFTLATSDDNTFDLVYDYTFFVAIPPIRRKEWGRQMAALVKTGGYLITLVFPLDPPQDIGPPFFVRPAHYVDVLGGGWEKVIDRIPERSLETHKGRERLIVWKRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMR3</accession>
    <name>A0A2R6NMR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMR3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10277" checksum="7F0096053DD464DB" modified="2018-06-20" version="1">MSRNLWQASSTSDFDGGSNTDSKESASSAFGLDDISRTEEYSKEAITDLRISMDGRILMSAGNWAGTHLSLYESIVSSGNLGQVDFNARVLAHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMR9</accession>
    <name>A0A2R6NMR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMR9"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24432" checksum="E3D83D0A4F9C85B4" modified="2018-06-20" version="1">MRQKILSGLDDIDPARLNLLDLELTSEDSIANAAESLSRMLPNQKSYIHTAFFTGGILHPERQPSQLDAQHILDSFKINVISHLLMIKHFSRFLPPPAFHSNVTPGLAKWVHISARVGSISDNQIGGWYSYRASKAALNQVIRTFDIHIKAKNLSAICAGVHPGTVKTDMSKDYWSGVKEGKLFEPEFAAERLAQVVEGLEREHRGRIWDWAGKEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NND2</accession>
    <name>A0A2R6NND2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10273</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NND2"/>
    <dbReference type="STRING" id="98765.A0A2R6NND2"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015362145" description="Peptidase S53 domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="10">
        <location>
            <begin position="214"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR73915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="559" mass="58716" checksum="F33759F28D8EB147" modified="2018-06-20" version="1">MVASTFFLVSLFALALGNPLSRRTMQLHESRDEVPEGFVQQGAAPSDTMLKMRIALTQNNIGGLQEALMDVSTPSSALYGQHLSKEEVEAFVTPSADTVQAVNAWLSENSISATTISPAGDWLAFEIPVSKANELLDADFTVFQHTETGDQSIRTLAYSVPSDLTSHIELVHPTITFPNPFAHLPVVISPGPAKGAVKPSNLSSDAVPASCATTITPTCVQDLYGIPTTKATESSNQLGVSGFIEQFANQQDLKTFLTNLRPDLPSTTVFTLQTLDGGSNPQTNSEAGIEADLDTQYTVGIATGVPVVFISVGEKFQDGALEGFLDIINFLLGESNPPHVLTTSYGQNENTISRALANQLCNAYAQLGARGTSILFSSGDGGVAGSQTTRCTTFLSTFPSGCPFMTSVGATTGVPETSASFSSGGFSNFFGTASYQTTAVSDYLTTLGNTNSGKFNRSGRAFPDVAAIGDNVEIVFQQESGLVAGTSCSSPIFASIISLINDKLVAAGKSPLGFLNPFLYSTAASTFTDITTGNNPGCNTNGFPATAGWDPVRELRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNE6</accession>
    <name>A0A2R6NNE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNE6"/>
    <dbReference type="STRING" id="98765.A0A2R6NNE6"/>
    <dbReference type="OrthoDB" id="2413468at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="28061" checksum="A779BE0A28B389CE" modified="2018-06-20" version="1">MDFHPQPRHTSDASVSSQTTFPIRNDAYIATDLSMRPGDELTSTKSPPLYLPYPALASSPLRSASALPSAARSYQVPLSNGPPRSGTGFFASMGRKASLKKDRGPVISPPSPSRVLTKRFPNQNNQVPRALQLNSAPAIRGGPRAAPGRVQRSQTISIAPAPAPAQEQPVTVARSETSHHRQSTSNRRPSIFHRSTQPAAVAPVAIASPEFERQVDRLADLLPNADRKLLSAYLRRAGEDVLAIGQYLEDEKNGTLRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNZ2</accession>
    <name>A0A2R6NNZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v10120</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NNZ2"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR74164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="193" mass="20873" checksum="049D95BCEBB719C1" modified="2018-06-20" version="1">MNGVCGSLSVFMSAKYLLTNDVDYLWSALILPVAGLMFDFMDGKIARWRGESSMLGQELDSLADLISFGVAPALLAFDVGLRTYLDTVVLTGFICCGLARLARFNATVALVPKDIKGKAQYFEGLPIPSSLGFVSVLMYWTKQDWIEGKAGIPGGTITLWGRQGGDGDLHLVSIVLAFWAAAMVSKTLRVPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP93</accession>
    <name>A0A2R6NP93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="2">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP93"/>
    <dbReference type="STRING" id="98765.A0A2R6NP93"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="158" mass="17244" checksum="F2A6E3FDD9EB6352" modified="2018-06-20" version="1">MHVTPTQLAWRPLMAPAGSGVNFIQGLKTMMGNGSPLSREGIAIHLYAANASMEKTAFVNSDGDFLIVPVEGRLDIQTELGKLMVRPGEIAVVQRGIKWKVVLPDGTARGYIQEIFGSHYELPELGPVGANGLANVRDFEHPVASFDIDQTPWEVIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPL9</accession>
    <name>A0A2R6NPL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPL9"/>
    <dbReference type="STRING" id="98765.A0A2R6NPL9"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="34382" checksum="9E0D9124373412B8" modified="2018-06-20" version="1">MASWTTVEEDATTRCGHCDNCTRAPETVVRKDVTLEAWQILKVAEYVQERKGTATLGQLSELARGGAKSEFNFDSHTRKGKQGSAKGSVDLENVCGGKVQLPKEHAEGLCMKLLLDGYLEEAPSVTIYKTIFYLNSGPRARDLTRFTRDELERGKGPKIVFSFLRKSRRVPSEKTRKESSFAQLDSDIEELPPSAHPAASSSRKRKAPEALELAVALGAEEVADDDGEDAGQSLEDLDSDDFMPQVRFYHGRVVVPESDESDFEEQWQSSLRPKPTKRRRTRISHHDNRASTSSRLVEDHEVISLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPW1</accession>
    <name>A0A2R6NPW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000979">
        <property type="protein sequence ID" value="PSR74512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPW1"/>
    <dbReference type="STRING" id="98765.A0A2R6NPW1"/>
    <dbReference type="OrthoDB" id="3260031at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="186" mass="21693" checksum="0DA659109732521E" modified="2018-06-20" version="1" fragment="single">MPMRGERNAPIFDPDVPRTLSRYFDDLIELFTRCAVVNDEEKKRYAVMYVPIDVADQWNYLPEKAAPGTFEDFRKAVFTLYPGASTDRQFEYSDLLAVIQEWQQKGISSLTQWGEYYRAFTLRSSFLKGKNILSELEQRRLFMQGITGLLKQAIERRLEIKQPDHNSSVPYEMKDIFEAAHHILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPY7</accession>
    <name>A0A2R6NPY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPY7"/>
    <dbReference type="STRING" id="98765.A0A2R6NPY7"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="463" mass="51037" checksum="76CB7EC05AAA9410" modified="2018-06-20" version="1">MAERFVDPAWSFTLGWMYWYNWTLTLPTELSAAAVLINYWTHSAKYDAVWITIFLVVAILINMLGARAYGEAEFAFASIKVITITGLIILGVVLDLGGGPNHDRIGFRYWKTPGPFAQFDGIGGPKGRFLAWWAVMSQAAFSFFGTEVVAIAAGEAKNPRRNIPKAIKRVYIRILLFYIGGVTIIGMLVPYTNPDLDLSESDAAKSPFVIAMTTAGIKGLPSVINAALLTSAWSAASSDLYTSSRALYGLALNGHAPKICTAVSSWGLPYIAVAVNSSFGLFAYMGVSTGSGRVFTWLVNMTSISGLMSWFGIAVTYIQFHKGLKAKNMSRKDLPYTAPLQPFLAWYAAISCFVICFFSGSSVFMKGGWSTADFVTNYLPFITFPILYVGARFWRQSHFIDPKDMDFKSGLAEVEAASYDEPPPRNWVERFWGWLDFILRLPTLGEPRSLKAERNHAAGCGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQU8</accession>
    <name>A0A2R6NQU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BCD1 alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQU8"/>
    <dbReference type="STRING" id="98765.A0A2R6NQU8"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCD1 alpha/beta" evidence="2">
        <location>
            <begin position="66"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="436" mass="48818" checksum="64D8363081AB7D8C" modified="2018-06-20" version="1">MDDYVFLEEVGRKVGDWGKEIVTGGYQATAGNGLHEEPRGRGRGRGRGRGRGRGGHAVQMIRTKRDALRTELERRDVEMDLLPVGMERRILNQSTWDFNNRTALLTIEFVFHPPKFLLPSSAQRTEPIRMLTHRNRLDGSLMVNIRARLGERANSKKKEKEKALPEWLTDMLIPHPDDPESFSEPVCVMPTKLDPLASLSARPGAHALLRPGHITSAAFYKLAYSMPLDEVMKHKYFVEFPTIEFWEEGAFTGTIVDDHGSIVRADGEGDDWVRKPKRRKLSKKEGKKALGGLLGGYGSNTDEDEGEDAKEEKNVFNLLAGYEGSDDENKTGVTHKTLFDSQFDYELGDEDAEGETDDGMGEYDYDEDEPFDEEDREAGGGKPNDPEAVAILLGQLRQAGALRDPGDDHRFRDPGDGDDDQVDWGDSADEADHEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRF7</accession>
    <name>A0A2R6NRF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRF7"/>
    <dbReference type="STRING" id="98765.A0A2R6NRF7"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24310" checksum="9B17A47259115551" modified="2018-06-20" version="1">MASKSPSLYATLIILCTALNMFLFARRLQGLRRQPIPYTYVGDDFPEFLPHEPLRGDLSMTFFADPASSFPISGPGTAELWESIYPPGYGFVRLGDESRLLCVAMFHQLHCIEKMRIFLDDPTNKHVAFGHQQHCMNYLRQLFLCKADLTLEPIIDLDYPAQALDLSVDLVMKSGSRVVHSCGDWETVYDTVGDNYKKWKASWNISSPFTSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRM8</accession>
    <name>A0A2R6NRM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TERF2-interacting telomeric protein 1 Myb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000905">
        <property type="protein sequence ID" value="PSR75362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRM8"/>
    <dbReference type="STRING" id="98765.A0A2R6NRM8"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="2">
        <location>
            <begin position="149"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="857" mass="96656" checksum="AF98567BBE8F827D" modified="2018-06-20" version="1">MSSPVASSSRARRTEGRQTGEQSAGAAGYPQIFVHNDGRPVRFYLEADRDYSISKYQLPLTANYVKSLARKITRHGGEICFDKEDAHVVIVNEAALEDYKYYYAYDLQIDAEQPGFISKCIADRRYVHLRPRRKPMGGVREGLKKWTTYTEREERLICKWLAIRIPYASSGGRKGNKVWQQLVEYAESFPEGEWALGTNHSWQSWREHYKKNQDRFDPDINEIVKRLPPRIYDKGLFELDRDMNRRNRVRVEQRNGEDDEEEDEEDEFVYEPRASLEPEPEPELPSRESNARETDEVEDILTVPTAKRKRIPVTPRSNQRRKATTSLTQESAPFQRHSGARPTSYRREEEEEEEEEAIEPVEARVVADEVQPEIEDAGPPGTQNSPTQTLAPSTPGRSARTTITSTARATKRNAPRPLDINSASSDVPMSSQATLVGPVPTQLRGGEELPVTQIRGRQAEVIVIEDSPVHGETQQMRTGLRTRPRQDGPELEEIGRQPPSAPITAARKSKRSQMLLGVVVPQPSQGDAPYRNTRARARSVSVEPVQVQSTAIDRRKKTKILTEVVEGSGSEESEGGGELDHKPDGMERPSEPVEQGRFKEYMEIDEADMQLQYDTSMVSTSLAVDDTDQEFEASLNTSLQQDGADVLHSPDDERTHRNLFNELQEEEDSISVVAVEVQETQSSSNIYRVDNPEDKHPSTNSSKHPFEESDEEEEPSYETQPSRHLSTRSDRPHASRTFSERGTEAELPIRTYSAVFSPNRSTQRPGSSTALHSQPSNPRSSLGSHTLVDSITSSAHTPNLYSRRVYSSNTPSQPANTSVMGTYARDILEQPSVDTQFRPRPGTRAHAHDVMSKARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU50</accession>
    <name>A0A2R6NU50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU50"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="136"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR76684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="297" mass="32679" checksum="5D78CB23E1A84B82" modified="2018-06-20" version="1">MAWSVFSTKAKGPPSPARRPSLRRSLSSIRNHGAGSEIPAIDDAGAHFRTNGSQGTLVGSDRRPSTPLTEFGSQKSVKNRSPLRDSVCKEGKDDGVNRRVSTASTAASYKQRLSLLRRQSREIFEHVEPYEDRVNFILILAQALLSFGAPSHRIESQLDSAADILQITVGFIHMPGVIIANLMDRGTVVSETRFVRAGGRIALTSLHRVHLVYRDVLHDKVGVREGTDRLRKLLRARPIYPIWIRCILAFICASIICTTAFGGSLLDMFISGVGAFVLQYLGLNVATKSAMYANVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUI5</accession>
    <name>A0A2R6NUI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000825">
        <property type="protein sequence ID" value="PSR76919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUI5"/>
    <dbReference type="STRING" id="98765.A0A2R6NUI5"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="239" mass="26380" checksum="6EFDEE940D7F3CB7" modified="2018-06-20" version="1">MRRCHEHTQALLDAFKLKTLWDDYGVVGDFLPFTADFPRADIHELLSPHLLHQVIKGTLKDHLVAWVEEYIMANHTGADVSAILADIDCRIAAVPLFPGLRRFKDGRGFKQWTGDDSKVLMKALGQMFLINQRLDKLAAAHVDFAARGMLNGPCVQLPNIVLEQLLQSAEATPLPSKDEDGNSDDGASDDEEGVAEGNTIDAEVVLAKCYDIQSGSLSLLLRLVFWHFHDSSVASSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUQ1</accession>
    <name>A0A2R6NUQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUQ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="548" mass="57989" checksum="192D741B0FEEF73D" modified="2018-06-20" version="1">MFFAPIFFGFLVASIFVSSPGLVVDILQWGQLSTRLLTNGVETYKLLFLSTTPATADVLQVQSITLIGSCELPTSTILAGLLSPIAAVTYDTSLTVLTTPTVPSASAVVSAPVSPILLHQQQSGLVVAVMILTVCLGLFLWEASETIFNSGGEIAETALPIVSVALASSDPVKETGAGVTTSDTTTPSCLFEILGLPVPQEFSIYDMLLESITFCTTFQDIEINIPDLLIQHTTSSAYSSDFSLTYIPSESSISYPSSPITQFLIHPASSVDSFTSALSYTSSINSFASAASLLNTDSYSAADVSSLSLSPIPVIGIPSVSATAPSSPTATADDTGVPKKQRARKRKGSCQVVDLKAQDKECTAAPPIVTVEATQDSSTSLTTSPPSGTHKRSRRAGKTRHGRKFEAQRKNAAAGPSTAVVDASASKATPSSSSPTLVSNLTATYPFHPARPQDAPFGMIIIGRQNLLIEDKDRPIEYLPHCPYTRLSAKAKSKSKARSLSNATLNADDDLHCMKKGTSALGTGRHQLVDLADIATFRPPRKPRRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV13</accession>
    <name>A0A2R6NV13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000803">
        <property type="protein sequence ID" value="PSR77285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV13"/>
    <dbReference type="STRING" id="98765.A0A2R6NV13"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="13190" checksum="AADCCD062515E571" modified="2018-06-20" version="1">MVESPSASEVERGTTLSIDQLPPDIFHSETKALLVPSDSSPADNLKRLVQECGVAPHKISELLHELPPRNLTDKLVDLYFTGMGRDQPERIPFPPTSFRDTSNFGQTGSGTRSWRRTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWM2</accession>
    <name>A0A2R6NWM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000760">
        <property type="protein sequence ID" value="PSR78066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWM2"/>
    <dbReference type="STRING" id="98765.A0A2R6NWM2"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="519"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR78066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="825" mass="88292" checksum="0C6DEFEA436157B0" modified="2018-06-20" version="1" fragment="single">MAYRRSSGRAYSSADAYRSLHNPAYSPTTPTTPASPPSSNSHAHHSSSSEEEAAHLTSPMPRSASPSQEDHYPNRDNSPLSPPRPFFLANSKKQSSDRNSWSTNDSLEPASDSDKDTAGDAGSIGVLAPTAGQRSANASSAARRSRANTAGSSGVVRPRNHHRRRSSDATVPASPTVANMAGVGASAAIAANSGRNPFDTPLETPTSARAPPSAFPFLSHAGNPDPGTPIPGVSALGRRTSHESFRRNSINHGQGQGVVYPNSPSSTAGGGYSALRGSMDISPEEEDLARPYAPFMGEGGVVGDRQSWVSNTANGNAGGSVYKNSAAAAMSSTTALATLGEGGASLPRTSSQPQIAMRAPFLSPASRPTSSLWSPPSYPSLPHLNTPGQHLTSTYPPSLTYLPSSSSSNPYLMPRKSKPLMPSSRLPTKLSADEKPWMRIKGKRERLSWWFTFFMMFLGVGVSAAVIYINWIGVHLLKDSDVCLVLDENFNNGGLDTNTWVRDVEMGGFGNGEFEIATASDDNLVIRNNQLYIIPTLTSDEIGTSAIFSGSYDLGSACTVGSDQSTFIGGSSGGNNCSVTASPGSTVVPPVKSARISTKGHYSIAYGRVEVRAKLPTGDWLWPAIWMLPENNTYGGWPLSGEIDIMEARGNGPSYPAQGNNFVRSSLNYGVLNTLQTHIVGWWQEKRFNYAEDFHIYGFEWTPDWMRFYVDSRLQAMMNLKITGKGGHSFFDRGDYPAVAHNGSDAEVAIENIWANAGAPASGPFDQSFYLILDLAAGGTSGWFPDNVGGKPWFDGAETAQLQFAQNQSVWSKTWPTNDDDKAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX79</accession>
    <name>A0A2R6NX79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX79"/>
    <dbReference type="STRING" id="98765.A0A2R6NX79"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="554" mass="60921" checksum="B1A6356771B05B47" modified="2018-06-20" version="1">MSKELGTLVVVVLKARNLPDKHSFFKQDVYTKVTLGETTKQTGIDVKGGQHPVWDEELRFEVFEQSKKSAKTLELSCWSKEPRLDDVVGKGELDITETLQSGEFDVNGVQRGELYLEMTFFAAGPPPALSRRPSKMTQSDRLAPPKQSSPPRTNDHHGSVSSTSPARTHLLLPTDPHRGRLSPKPSESPLPPLPDEPVVTPATVPAILRPGAGRLTSPSPPDAARNTPLPHTPPRSISGDRSNAATPRIHHSPGYVPPNLRPGPVNGASPTPRPSSYVAEADIPSLPVSTLGYTSPVPAPVSLTTVYPTYHSPHIDQQRPIPALPANPQPTSWHSPPPSHPNLQPSTYSVDPSSSPIPGFAFPTPHVPVRQQGSYPSTYPANYPSHPQAFSPPSRPYPYNYAPPPRDPDLDLPDPHMVARYRKPLPLPDEPEGMQTPTVAHPQSHVSLAAVSSRPHDPATRTHTDVAPTSHRQSLHERDEERDRLLALAFEHEEDERRKRAEEQEEIDRQLARRLDLELNLTEEESGGRDEMVLNGTQTPGSMPGGWYRHRVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXT5</accession>
    <name>A0A2R6NXT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v6992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000693">
        <property type="protein sequence ID" value="PSR79531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXT5"/>
    <dbReference type="STRING" id="98765.A0A2R6NXT5"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="11">
        <location>
            <begin position="213"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR79531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="629" mass="68593" checksum="8187947A6982EB14" modified="2018-06-20" version="1">MSSQPSQQYAFRAQKRLGLVGGTPNYDTLDSFEGPDVPARTYQYSSDGRLFAYAVPTGIRIFQAESAQLLQELLLPNIVEMNFSPRGTYISTWERPNKLEDGAQHKNLRVFSVSTGEELISFTQKSLEGWDLQYTISESHAIRLVSQEIQVFRPAEWSKGVVDKLRVEGATSITLSPGLNPSVAVFVAEKKGAPASVKIYNLLSLNGSPLSQKTFFKADRSQIKWNTIGTHVLVLTQTEVDQANKSYYGETGGLYLLSASGTFDCRVTLDKEGPVHDFTWSPNSKEFGVIYGYMPAKTMLFDQRAKTLHDFGPAFCNFISFNPQGRLLALAGFGNLAGKVDIYDRRTLSKVTTLDASNTSHCEWSPDGRFLLTATLSPRLRVDNGIKVWHCSGPLVHIQHIEELYQASWRPTLVDAAPPFPQTIPPAPAPSASVIEHAAVAKPAPARSAGAYRPPGLRGLEASSVYKREDNTPSPSGTPNGRYSRSPAPGRAHNRKHVPGAATSPSPVRNGNEPDKRGRKRKGPKEGKKDTTVAVAALEEQARPSIEIQVDGIGAQAPTNGSVPPTPGADGGILDPIAKKVRNLNKKLKAIDELKEKANKGERLEATQLKKIETEAEIRKELAGLGITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXW3</accession>
    <name>A0A2R6NXW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXW3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="16172" checksum="CC5DF7A862A6B695" modified="2018-06-20" version="1">MAYHNAQLAEPDFSNVAVLHSYWQLAVDPSDSPNVAIPAGLTPRDLIGYGEDATEKGANYMLSARFEFIARVMQSVYHAALLWTPSSYVKDTEALFQTAYLGEPKVFAAVPMSRYRDFDHTWACFLGNVASQWDFLRIACAVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXX2</accession>
    <name>A0A2R6NXX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v6917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXX2"/>
    <dbReference type="STRING" id="98765.A0A2R6NXX2"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR79616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="502" mass="56622" checksum="57F624D717EEB27E" modified="2018-06-20" version="1">MDSLMPRSESARLRGQSQMDFKTATTGVAAKAMRNEISSLVKSVGDPLTKKAFDTEMQSFFYLFTRYLAKRAHAQDLDWDRIKSPTEDKIVPYAKLTSGDSKNLNKLAVLKVNGGLGTSMGMTGAKSALEVKDDMTFLDLTVRQIEHLNTTSRVDVPLILMTSFNTHEDTLRIIKKYANQQLRITTFNQSRYPRIYKESLLPCPKTADDDKKNWYPPGHGDLYNALYQSGVLDQLLSEGKEYLFVSNSDNLGAVVDENILQHMVDTQAEFIMEVTDKTKADVKGGTLIDYDGQIRLLEVAQVPNEHIEDFKSVRKFKIFNTNNLWIHLPALKRVMDNGEMELDIIVNPKTTDDGQAVLQLETAAGDGIQFFRNGHGVNVPRSRFLPVKSCSDLLLIKSDIYSLEHGQLVINEQRMFETTPVIKLGDHFKKIAQFQKRFKKIPKIIELDHLTVTGDVYFGRNVTLRGTVIVVANEGQRIDIPDGCILENRLVSGNLNLITLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYW5</accession>
    <name>A0A2R6NYW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v6667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYW5"/>
    <dbReference type="STRING" id="98765.A0A2R6NYW5"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR80751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="360" mass="42580" checksum="1E61FFCF1008BD15" modified="2018-06-20" version="1">MGRTAPKSVSRVYADVNGKLGPSWYEYDNLQVQWGAQDHYEIVRKVGRGKYSEVFEGVNISNEEKCIIKVLKPVKKKKIKREIKILQNLAGGPNVIALLDVVRDPSSKIPSLITEYIHNVDFKVLYPRFTDFDVRFYMLELLKALDYCHSKGIMHRDVKPHNVMIDHERRKLRLIDWGLAEFYHPKTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSYGCMFASMIFRKEPFFHGHDNYDQLVKIAKVLGTDELYRYIEKYDIALDSQYDEILGNYPKKAWSRFITSENQRYISNEAIDFLDKLLRYDHQERLTAREAQTHPYFDRRASSRKVFGMQSVIYPRPFEPRKLRIGGSRHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ66</accession>
    <name>A0A2R6NZ66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="8" type="ORF">PHLCEN_2v6459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ66"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ66"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="614"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="163"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR81124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="877" mass="98555" checksum="02A43CAD342BD0EC" modified="2018-06-20" version="1">MSRFFRQAGDSDSDSESSSEEELMSSGDEAAPKPAAAATTKPAMSRFLRSAGDDGSSSESESDSEDESDMSSDEDAEKGKKKSRFLRTEDDEDSSDEEGGKRVVKSAKDKRLDEMETAGKTMENALKINDWVAISNEFDKLARMVQRQQNISEPVPPFYLRTLSNLESALNIAVAKEKEAKKKMNASNARALTAMKQKVKKVVKENETELKKFQEDPEAFEREYTSTLAVETAPTAARVKKGKKPAEESGEDEEFTTVGKGGKTMQFAPESIFKNLQLVQEARGKKNTDRPEQIRILEKLLEVAVTSYQRIRVLLALISSRFDYNSSVATHMPIDLWLSALREVDQLVAIVAQDPQYSVQEITEDYDELLERSPETEADGIVRIRGSIISFVDRLDDEFTKSLQNIDPHGTEYVDRLKDEKGLYCTICRAQAFYEKTKQDEPLARVIMRRLEHIYSKPDAVVQALESAVSASDIKPSILLPAQGEMKDLIHSLCVYLYKAGNSLLRTRAMLCHIYHYALHNDFHTARDMLLMSHLQESIHSADVATQILYNRTIVQLGLGAFRCGLIKESQAALQDIFATQRVKELLAQGVHQQRYTVLSPEQEKAERQRQLPFHMHINTELLEAAFLVSSMLVEIPLLASIDNEEQKRKTISKSFRRLLDFADRQVFTGPPESTRDHIMQASRALQDGEWEKCRDLVQSIKIWSLMPECASVKEMLAKRIQEEGLRTYLFTYAPHYSTLSLSLLSRTFSLPLRTVTSIVSKMIWNEELSASLDQATGVLVFHRVDLSRSQQLAQVLADKVNALVEQNEKALDQKLGAASGWNDRGDSKGDKRGEQTQERKRGGERRGGIRGGARGGRGARFAQGLGNQMSGAQRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZT9</accession>
    <name>A0A2R6NZT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000609">
        <property type="protein sequence ID" value="PSR81710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZT9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5949" checksum="D32B6129EAE242D8" modified="2018-06-20" version="1">MDQVPCSLTIAQKLRWYTEMALEQKPHLQCSVGYFSETQHKASQARPHMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZY4</accession>
    <name>A0A2R6NZY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000609">
        <property type="protein sequence ID" value="PSR81722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZY4"/>
    <dbReference type="STRING" id="98765.A0A2R6NZY4"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015310924" evidence="1">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="203" mass="20486" checksum="65E574E4C92A4A45" modified="2018-06-20" version="1">MRVSTVLSTMLPIGAALAAVIPTGTVLPLTALLPEATSAAGIATSDFPANVQIVLVGDTNNNPVFFPSNVTAVSGDTIAFGFTSGNHTVTQSSFADPCTTLPSPSFDSGFVSASVTEAASQVEVFLVNITDANVGQPLWFYSRGEGDCHAGMVFAVNPTADKTFAAFQAAAKKTKSNSAGPIEVFGTAGALLTGLGVLAGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZZ1</accession>
    <name>A0A2R6NZZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000606">
        <property type="protein sequence ID" value="PSR81816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZZ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9765" checksum="8125C8517BD720EB" modified="2018-06-20" version="1">MAIKKLAKISWSKMGLWRIHETHITTPFHHDTAAGPGMLFSDDGTMKGRRIFQSIHAVLPTATTCATIDGDRVYSIEGYLRMSDMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P004</accession>
    <name>A0A2R6P004_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v6266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P004"/>
    <dbReference type="STRING" id="98765.A0A2R6P004"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="146"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="275"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR81757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="452" mass="51509" checksum="6F734C7D7D63004E" modified="2018-06-20" version="1">MTLDVLHFIDNKGGNAKEIRESQKKRGLSVELVDEVIQMYADWVKMDFDANNISKQVNAVQKEIGLKKKAKENADELVAKKKELDDLVIAKRAEAKEFEAKMRQKASTVGNIVGKDAPISLTEDDNQTLRTWHPEGPNGLVQKKADIMPHHEVLLRLDAMDLERGAKIAGHRGYFLTNDGIDLNQALITYGLHFLRKKGCKNIQPPFMMNKDMMAKTAQLDQFDEELYKVIADDDEKYLIATSEQPISAYHSGEWFESPDAQLPLKYAGYSTCFRKEAGSAGRDMWGIFRVHQFEKVEQFAITAPEKSWEMFDQMIGTAEEFYQSLGIPYRVVAIVSGALNLAASQKYDLEAWFPFQGAYKELVSCSNCTDYQSRRLEIRCGLKTKDQARKVYVHMLNGTLCATERALCCLVENYQTPEGLVIPEVLRPYMQGREFLPWVKELPKNLQRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0T2</accession>
    <name>A0A2R6P0T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0T2"/>
    <dbReference type="STRING" id="98765.A0A2R6P0T2"/>
    <dbReference type="OrthoDB" id="2421327at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="84" mass="9550" checksum="A2FEB67C2F1E7493" modified="2018-06-20" version="1">MSIRRIGNTKTLPPNPKWVELPRSDGDRSQWPKNTERVVDHEGCVNFMRPIDIDEAVSITWRVAAGKMIAQTLKLDGKCARCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P185</accession>
    <name>A0A2R6P185_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000565">
        <property type="protein sequence ID" value="PSR83157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P185"/>
    <dbReference type="STRING" id="98765.A0A2R6P185"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR83157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="331" mass="37487" checksum="DF73F6AC780284F0" modified="2018-06-20" version="1">MAETLHFATGRAKTVSLPDLISAIPYTVHRNPHTDSTTAASNNWFLETASFSVLQERKFCGMNIGYLSGRCYVHCGSKELRNIADFLSFLFCLDDWSDEFDTAGTKGAADCIMNTLYHPSTYYSSTILGIVINSIWSRMLTSIGDHCGQRFIQTMDLYLQAVYRETFDRELGNIPTVDDYIKLRRDTSACKPSFVMLEYGCKIDLPDSVIEHPVMHELENAANDSVSWQNTHNLVIVLMYEKGIGYQAAIEQAADMVRDTIVRFETHRARLPSWGPELDEMAVTYIQGLQDWMIGNTYWSFETARYFGSDGAKTKKTLRVPLLPTKLQTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1W8</accession>
    <name>A0A2R6P1W8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000552">
        <property type="protein sequence ID" value="PSR83732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1W8"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR83732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="462" mass="48625" checksum="3896A89341274A60" modified="2018-06-20" version="1">MIQQSEDSAASSLLSLSVAAANAVPILTPQDSAAPLALGSFNGPSSLSHDSHSTTSKLHNALKQRRLSSTGQLKRRLSDAREATSRPSAATIQTAAAALQSLATLSLAGSPPPQAVPHTSTSFASAAGQMHLGGSDTSEGTSVKQEEEDFATSVSATARGELAAGGISIKLGNGKKRGTIFTCESCSKVYRHPSCLIKHRWEHSPHWREASKFLLSKHQQVQMLEAAAILSHLSPANSGGHSLPEDRSLWPSFLSGGLLPPPVANGVSNSGVSSTQDTSASSSETHTPLRVSSSVPAHLSMSRPTSAGPRLHDYSIPTSSGITHVRPGVLGVPTGSSPASSVPVPVPVDMNAYRESNRYGSPISYSSAFGAQSYDTGGSWSLPRSSVRSRSTSAPKSEGDEGVEVEVDIEGDDLGDQRYGFISRGRMSAARDGMKDEDDGYMGNLREEKIEEEWDGEMEMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P288</accession>
    <name>A0A2R6P288_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P288"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015347525" evidence="2">
        <location>
            <begin position="22"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR84198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="425" mass="45580" checksum="F52CF2DF06EA110D" modified="2018-06-20" version="1">MRKAARHFLAVSLLFHGLSAAQNLTDDQLSQVKQRLAEGALQSWELGTRAQALTELDTSAYSVLTVDASLPPSQSSPPSSLDEVFGIAKSVVGNRSVSNDHASGAQPLIADSAAGDPASIGVAVLLANWTGQASQDKLDYAGAATDQLNYLFNDVPHTSDGAISHRVSQLQLWSDFVYMVPPFLSYYGVVTSNQSMLQQGYNQIKLYRQYLRDGSAGGLWKHIVMGSGTDEGHWSTGNAWAAAGMLRVLGTISRSQFANNLKGEQSDLSSWVSEIHSAMYPHMRSSKLFGNYADDNSTFDDASSATLLASTVYRLALLSGNTTFLPQAEQVRQAIFGPATSSGSNNGSSLEHFTSDMWLTPVVNPHSFGDEGSESPEGQAFVVELDAAWRDWVQAGSPGVNSAHATARASWCLWVVIPMVLVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2E3</accession>
    <name>A0A2R6P2E3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000535">
        <property type="protein sequence ID" value="PSR84398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2E3"/>
    <dbReference type="STRING" id="98765.A0A2R6P2E3"/>
    <dbReference type="OrthoDB" id="3271094at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="179"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR84398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="445" mass="49773" checksum="3578EDDD3398BDDF" modified="2018-06-20" version="1">MSIVAFTFGSFGDIFSLVGLAISIAKALSDSRGSSADCRELIDYLNAFVRHLYCSDDILSPFYADNGSSSDRSQPRLNRLAVIAIGSAIATCERLMTGFQTKFDPYQQSLVHGGSRRLGVDIWRKIRWMSFQTEVNDLRRKIDEQRDVIAMMLSLCNLTLTAESQKAPARLHTPSQVLGIYLTDLLDEKVFVPIQHCGSQIEFHQYLKFFFRNRAGRTFVDRGNYDLTAQSTNQLVIHQSWAESVKPGMALVMSALVKVSKSDRGVCPKCKILNDAASIEDELNEIQCSYCRTIFRVFDDRFEEVEDESAQVTGLTTGANSSAQSKAGADRSPHRRTTEDEAQYVRRISVIPLVLVHSPPQAAISQNPYENLNYRKHYGHMSPKTMAALPRFSDGLRRSSAGDLRPVLPFVLDDDDLLVESPEEEGSGYPFGEDNSVDEVEYAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBU1</accession>
    <name>A0A2R6PBU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PBU1"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015348491" description="Mediator complex subunit 12" evidence="2">
        <location>
            <begin position="17"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1352" mass="150718" checksum="664811D8B09F1B73" modified="2018-06-20" version="1">MWLFLVLYGFFEFLEEMRRYVTQVLSKIPPSSQYRVQAGLRNRPAYNPTQYSVEWANVVTSYMRKQLLEIALPMAPRPGLNIKHTFKGVLADQDSRDRWLSRFTYCLALLRTFYSEGLVDNRTFLTWLVQQTGSCNLAQLGFMLRLADEYLEGMLISRALTRPFVDACLNRLTEIRANPAKDHLATSESILKNLILRAFITLPDAFVSPRLWVQYSGLLEELFLEHLDKVAVDTQSKQSVLALNQTLLDTLTDVKTRNHAMLFRDLPPRVLGSLSSALSDIKLLNSLSGKSDMEAVCFFDDVAEDSPAFTRKLDTLLTWSVTPLQYGDHRPYAAASILRFWRGRAEERAIRRDRDSPDDFIQDHLFDWLDSSEAASDAANLSSIALLYGQLVKPGLFSYPKYIQRLIARGEVGLSSSELTLFALEHASSHELLTAVIQTLQQHMEVWACLNMMANITSSLYTAHVTWKSRGVQSRPLLNLLLDVDDGHHLEQAAREQVSADSSAFAHALQPFSDNPCTVPAALPEILLLATDANLEAPSILANSLWYKYRSAPDWAWKVWDNTIASLRQIPSMIGDIAGRRECALRYAAFLRHVDQHTPSGFDRHILEWFIGSGKNEVAALTQEAWDVVTVVLLYLTVHGALATTTVLQGLIYPVWKMACNATSVEQASTVEVFLTAVNEVCKNLLLRDECSDGFPPVDFCEVHGLQTRRRDVYRAPYFSLLVENIPTLVLLEQNVNLSDYLRQGSRALREALCTMSVFRLGIYRDLDTVHSAFEKVLCNNEVAEDLHEPLINALRLMLNEGQQGCLEPAAGWQMLSTFLSPWKLAATSIELRFTMKQLGEALLRESSRDKASACLDNLTSNVFGQGMNSEEADFIAEMMKGVSTSVAGKFVNAGMRRISDLLNQCPRPLGNGDLHHIFTSVGEVLRLLTNVVDPLRAETSSMPPLEQNTQDKVVRALQSVFSAVFDAVSESKDSPGMNIVSEATILLARIVQFDLGFPGAWTEETKVISERLCLIVADLSLLYGSGSTLDPLTFPLLIDTLHYLLDEYPLDPKATTFDIFHNYPHFELHSLPSDMPFDYRQKIRALLPYVAPNASVANLAYASKDALETNLTPVQNRPWEWTENLGDRLAPEANDDKADEQTTVRNSASLPLELFAARPTGERIISSSSTGFNSRVEGEMRTLQDASSSESALKRDWRETRVSPERAISGPPRRAEQEDEVGAMPTFNTNTNNNGNNAKSPSEYRAASRVASPASSVRSRGSVQPPASLRQSPASLLGLTRLSGSSVGEPIDVDSLDIPASTSTSHNREKRTNTTESSMGSEDPDIVELSSHAAKKPKVRPAVAKPRTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBZ7</accession>
    <name>A0A2R6PBZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="12" type="ORF">PHLCEN_2v5107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBZ7"/>
    <dbReference type="STRING" id="98765.A0A2R6PBZ7"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR88756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="224" mass="25263" checksum="2B5D0499E1A838B0" modified="2018-06-20" version="1">MDWSSHYPAFVSTGKTPEFADVGCGFGGLLIALAPMFPDTLMLGMEIRVQVSQYVQDRIIALRTTSAISNAASPEPYQNVSIVRANAMKFMPNYFPKHSLSSLFFLFPDPHFKARKHKARIISPTLLAEYAYVLRPGGIVYTITDVHDLHEWMKSHLAAFPLFEPVAEEDLRAQGKGPIIDAVYSSTEEGKKVERNNGQKWLACFMRIEPLRILGRLNTHLHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCD0</accession>
    <name>A0A2R6PCD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCD0"/>
    <dbReference type="STRING" id="98765.A0A2R6PCD0"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR88886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="20887" checksum="9055BAAFE66C3D35" modified="2018-06-20" version="1">MFDLRRPDAEPEFFSENGAAFAHDGTVKSVVWVGEHTGVTAGEDGVVKWWDLRSRSLTTSLTFPNPITSMELSPQTNRLVVTSGKTVSFIPALPNGNQTHSLTLPYAPSSASIHPILQDRFVTGSISDEWVRIHSLDGTERDVLKGHHGPVHCVEFSPDGEMFASGSGTIRLWQTTPGKSYGLWQGPQTNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ56</accession>
    <name>A0A2R6PJ56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v4782</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000481">
        <property type="protein sequence ID" value="PSR92066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ56"/>
    <dbReference type="STRING" id="98765.A0A2R6PJ56"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="379"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="603"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="829"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="947"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR92066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1143" mass="126167" checksum="DE4C7D2BA71D6512" modified="2018-06-20" version="1" fragment="single">GPNFGIGIEPGAPAGLIFRDQGIKAMCGFSGVLSLLGKVETFERRSSAPSKSTARKAMLSARVAQYSRHVASTSALPAAFLHTTPAVRAASVKSKQSNIERRANRADLAGLNKPHVILGFRAGEDAKWTNCDLAKVMVTDEEIQSSPSPTLSITSSKIEQPTYSNFGVGEAEKDLLFNTLPALRTEALAVLNQKAKGTSQPAFLDKVGIATEKVEAYKANMLARVIDLRNANARGIAFENRRRCVAAFSDPEKPNDTGRPEVQENRPSKAMVDFPTCDSTQATSLSPNGPDNHIYPAPYLPFRRISLPSAPNLNHRLSVVSTASFDSMPEVPHVPVLVSTPKGVARGLRNRPSSVEAARRNQRRRETKSVVVDEQREAKRRKVINELHETERTYVDALELIYSHFLTPIVASLDTPNQLLDRAELTSIFSNFIDIWNLHRSFYSSLTSLLSASTSTSTEQEPPALSPVLLAHFPYLSLYTPFVSSFPDALSSYTALLVNNQAFATFMTTQEADPRCGKLKFRDWLLTIVQRCPRYLLLLKDLIGSTNPENPEYTSLTAVHSLVSKITDSLNASLHTHAQTLSLLAIQRSTANLPFQLVTPGRTFLKRGPLLQVIESTPKEREFLLFSDCIVWLSSADKADDADRLSRWEMLERESGVTEGSTSRPTISRTRSRSEAELSQAAGVRKRDSGLRLKLVGPARKKRQSSAGGEDKWVYKGHIDLVDLEIVVGPPREVGEQRRLEVLSPRKSFALYAFTEEERDEWCTAIRNAKAVLLVSLNVMHPNSTLTSSASTNHLRHALQAMPYSPDEEQRQPKRGRVEHFVPAIWIPDSKTESCMRCGRTFGWRRRRHHCRLCGRCVCSSCSNKTFFIRDASPKGAQKSARACDACYEAVFPVLDTAIEPQVPMTTISHLTISGLRSMPSLLLDHNANTSPSVLMAVDMENSRRPLSRIDAGSSPSYQSREPSDSAIPAVRIRPPPRPRSYIQILEDFHMHGESSPMGSPTNSRFSGRADDMSFVLDEREEDEERESQAHLSGEASPAHDPVSSPEQASPSVSLPLSMGRNEDTVRRRKRFSMPAVAIHTTPVTARPNMVGEGKSRRWSLVLGNWKGGGGHATEFADTLKHGAAATKLSELLGRHSKPQASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVM1</accession>
    <name>A0A2R6PVM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="16">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PHLCEN_2v4296</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="16"/>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVM1"/>
    <dbReference type="STRING" id="98765.A0A2R6PVM1"/>
    <dbReference type="OrthoDB" id="3238762at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF9">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015329386" description="AA9 family lytic polysaccharide monooxygenase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="19">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PSR97589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="353" mass="36025" checksum="ED3D6B8A563DF18F" modified="2018-06-20" version="1">MLFSLAVASALIASVAGHATFQELWINGVDQGSACVRLPVSNSPVTSVTTDDLACNANATPSSGVCPINPGDQLTVEMHQQPGDRSCANDAIGGDHYGPINIYMAKVSDATTAVGSSAAWFKVSEMGMPSNNPDYWATEVLNNNCGHFTFTVPTGIAPGNYLVRAEVIALHVASSVGGAQFYMSCYQVNVGGSGTSSPPTVSFPGAYSATDPGILINIYEPLSTYAIPGPAPFGAAIPAIANVPYPTTATWNTALQPSTVPTVMPSQSGKPATSNPVTSAPATVKTTAVPTPVSSSAVLPTSSSVAAGTVAEYGQCGGIGFTGATACVAPFTCTVLNGMYFSLLFRTSKNYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVN6</accession>
    <name>A0A2R6PVN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVN6"/>
    <dbReference type="OrthoDB" id="3052647at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR97575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="269" mass="28352" checksum="6DD6F3ABEBF32FBE" modified="2018-06-20" version="1">MSDASLDSTIYDDSSDQIRYIGPWYPIASSGSDTYNSTMSGLNEPASFSLSFLGSQVSVYGGVQHEEENLSVSPSISSAYSIDNVVIDTYNIVMPTGSDEFGVLFFTSGDLGASDHQLSVNITYTSPTFPYWLDYIIVSSPSTNTSSSLLSLPSTNPSSPLLSSPSTNTPNPLLSSTGSVHIHSLSIDLRSTSSVPVPSSTKSPIPSNSATPSTPVAQAGNAVLHTAAGLIAGSVIGGILLLCLLLGSLFLWRRARKEIRAPDEEESME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q281</accession>
    <name>A0A2R6Q281_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000414">
        <property type="protein sequence ID" value="PSS00606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q281"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS00606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="494" mass="54409" checksum="EA7EA6F1A0A08F8D" modified="2018-06-20" version="1">MSPSCNIATGVSSPHPILPHPPLVSQTPRLSTSKALAQRNKSPPKAPLRIAREEHRWRTKEFNSFCRAERERHRLRFNILDTEEESVVSEHSKKRKPPRSLTLTDITLQRQLQAAVEGVTSILARLSLCDKATTNTTDIFDDEFTVGAQHAHCGVASITPGSGTIDPKFLSDFSPPSYEDADADKSCQEPPDMPELMSSFSDTSTLNSPSSSSPRTPKVSTRDVPVLSPTLEYEAEAEQFLSKIRDDLSPLTLGPAESVDGDDVAELSRQIEELLALVPTYEPKQVKRPSRSGGREKLKALTGSVRPVRRAKAPHMADDVDQDKGVPTSATDVAEEPLEKPCNPEITYPPRRRASPDVIFGTSTGLGKVGYESTRRQRMKNVALPFAKSVKKIHRRFLLPELVADVKNYVPSVILRSSTDETRRLTQNREQPSQLQPLSAVLGLHNVGSTTSDHLPDFEEEGEEEEVKPGREADKEPTPAGSQLVTVCNSPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEJ6</accession>
    <name>A0A2R6QEJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v3622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEJ6"/>
    <dbReference type="STRING" id="98765.A0A2R6QEJ6"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="10">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS06564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="14060" checksum="DB9FEECB164EF0F8" modified="2018-06-20" version="1">MWSTAREIADGDLVIIWLVSSVVPLNRASLTLPNQTRDLVQPLLINAGKELNSRFGVYRHSDLIGTPYGSKVGSRNGKGFIHVLRPTPELWTLALPHRTQILYLADIAFVTSWLDIKPGSKVIEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEL0</accession>
    <name>A0A2R6QEL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEL0"/>
    <dbReference type="STRING" id="98765.A0A2R6QEL0"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="60"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS06582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="233" mass="25469" checksum="9671EEFEBE931194" modified="2018-06-20" version="1">METAAQSANVEGLARGTSSDKPSFSAPPEMYNPHRPLSKSSASVPQHGERSYDAGGIVPVAAALISQKQPDSFELDPQAPLRAIKQHSAGDILADSDGIRRWDAVSGDILDPVEEEEEQVHPTAERSSSKSKGKARDTSTKEDEGPVWGESFRVEWVRAERLPFYRTRHLRNPWNHDREVKVSRDGTELEPSVGQALLDEWDKPDSQQSQSARLGTKSTPMSAAAGSQIQGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEL7</accession>
    <name>A0A2R6QEL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase family 28 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEL7"/>
    <dbReference type="STRING" id="98765.A0A2R6QEL7"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF26">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="2">
        <location>
            <begin position="666"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS06585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="813" mass="90112" checksum="A769EC5812E9B120" modified="2018-06-20" version="1">MTANSVSSESSPLPSSPQDAGSSKPWQVSQDDWDLAQPSTISCLFKDATLYKKAIDELSSPRSKLNSLAEEETTNGFAELVGQDLDQPEKDVASQFAQISVKDWTPQDDDFDNARPLTEEPESFEEQSSSESSEGTTAISTDPGTTTTDRDEEVEPYVSLSSDQVIQLLTQEFGALAPDGEEKLVLEADGAVIQDVVVLGVVHITTHRISFHASMPLLDPSLSGSNNVIKAGPALVHRKGLHRKKRVWLELSQDFVSTFPSAREEDRIRPWRSVMLTSILEVSKEDPERPRVMQARLDSKTGLKDGYLEFDTIESAREWRRELQAALFFSRRKLRNIIANADADDIQGVRIGIPLDHILYHTRQLHANTLPIITLTVGSSGGQDSPLVPTSDAPAQSIQIAFNKLAAEWDRLDSLIKASKLRRDSDGLVPREKSVVIDFGLGDYLQKAKAAGTDAKDIRSKEQIVCDILAIDYSENVWVTRACLTVGLACTGFLVVSPRWIGFWSKSLTLRDVRYRLAASSIQKAVPTEFIIRSLPIYGMLLEIEGHSNLKFQFRSQNTRDESIQRINAAAEQERLLRIQSAIPFPSNFPTPPGPLSPTREASITLPASRPQTPPSPHSQGTLFSPLSRTFSRVRGTVDVRKVLQFPKAVNVPPGVMLRMPPKHFVCLTIGSRGDVQPYIALGLGLKSHGHRVTIVTHEEYKGWIEGFGLHHRQAGGDPGALMKLSVENKLSRLSETVCANILHSWFLDNPDLDWKAPESLLLFMEKARKDGKPLVYIGFGSITVPDPKSMTEHIVQAVTKSRSYVPPFFEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QET0</accession>
    <name>A0A2R6QET0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PHLCEN_2v3555</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QET0"/>
    <dbReference type="STRING" id="98765.A0A2R6QET0"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="233"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="462"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="529"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="785"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="1045"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="602"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PSS06836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124357" checksum="E701E2C505CFE5FB" modified="2018-06-20" version="1">MATELDQKIQDVYKRIQTERKVLEASQLLRQATNNPDVLRRNDAAIREAERSLSYFEDTLRELQSRKMMQSQRTDHSRSGSMASQSASSSSYGGSIPSARGPASPELRPVGGGPTYDSPEDPSQPKTYSNLDLIKADTPHTTAKISRMLHQLEFKLQVEMQYKKGIDKMAKLYQADGDKKSKADAESKKVESERKIQLLQTALKRYKTLYILDDAAAAAEEDDGPLGPAGPGVDGERKDNLRSKPLSGKLQITLKGARELDHAPIVSTGRSRSSSKAMETYVSFKVEGTQRARSHPTRTDRWMEDFEITVDKANEVEIAIFDKQVGELHPVPIGLLWIKISDLVEAQRRQKVLMETGQGGWVTAGAMNADGSMAGPTGQMGGAGGMDAPIGFGDNRAMGSAPATMGSEGVDAWFAVEPAGAVALRLNFIKENVRKRPLDAPGGLGRQGAVRKRKDEVHEMNGHKFVQRQFYQIILCAFCNEFLLNAVGYQCEDCRYTCHKKCYEKVVTKCISKSNTGDDDAEKINHRIPHRFEPITNIGANWCCHCGYMLPLGRKNARRCTECDITCHANCAHLVPDFCGMSMETANILLRDWKDINKARTGRVQRPGPTQSPSAQSQISQYPGGPTDMDQMMNDMDRMKLTGTEPPPPPKPADYGYGRQYQQTSPQDGRPPDHRMAAQMQQAPSPYPPGTPTSAPRPLPGGRPAFPTEPVQPMAQPGRAVPPYEQDGYYQSPVAQQKQYSASTSPVAQLTSPSERQMSLPLVPQQGQQQYRPPARKRKVGLDDFNFLAVLGKGNFGKVMLAEEKKTNNLYAIKVLKKEFIIDNDEVESTRSEKRVFLAAARERHPFLLGLHSCFQTETRVYFVMEYVSGGDLMLHIQRRQFSLRQAKFYASEVLLALEYFHANGIIYRDLKLDNILLTTDGHVKVADYGLCKEEMWFGSTTSTFCGTPEFMAPEILLEQRYGRAVDWWAFGVLMYEMLLGQSPFRGDDEDEIFDAILEDEPLYPITMPRDAVSILQKLLTRDPARRLGSGKTDAEEIKRHPFFKDVSFDDVMNKRIPPPYFPTVNGTADTSNFDEEFTKEQPTLTPVHGQLSSRDQQEFNGFSWVASWAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEY2</accession>
    <name>A0A2R6QEY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000345">
        <property type="protein sequence ID" value="PSS06892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEY2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7862" checksum="BC196D210B32E9F3" modified="2018-06-20" version="1">MVRTRNTTQDENNSPRRRAALTDSQKAKHQQRFQDLKNDLTGVQNAFNDSTQQIAEKYGRLVEKQSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUJ4</accession>
    <name>A0A2R6QUJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000311">
        <property type="protein sequence ID" value="PSS15407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUJ4"/>
    <dbReference type="STRING" id="98765.A0A2R6QUJ4"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS15407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="467" mass="52780" checksum="D25B75764F175B1B" modified="2018-06-20" version="1">MAQFLDLPLEILPFILQHIVRPSYLTQLSLVNSHFHEFATPLLYRRAFVYAWHREAKAKVLKLFGTLAAYPRLARYVEQLAIRDFPRALSPTEQDKILDMCLQAIRNCTNLRSCTWTRDGSLSTELLQAFCDVPHLSELEINGHSDRFYDHRILCRFSHLQKITLIMPSSSVVDILPTWVSHCDRLQHLTLICKSSHLLNDSILEEMAPNLAQLRHLYLVGCPKVTSVGLWAVLSANQDGLRGLGLEGLSPDFDIQRLSEICRSSGALRLLQSVTLALGNTKQTRHKNWSSEIPRLLESSPLEMFHVSSLGGEVGVDVSDDLCAAIISDHGHRLKRFSVHRMRVSPAAVEDICHRCVNLEQLFVTMEQDSLDNLGPILSLAPKLKALHIHRPVGMVIGGKGPVVTQEQALRIVKYCTWDLEQIGFNTKVWQIERVPQTQEDGGTNFVPRLGPYESPEIPEQFLVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXL6</accession>
    <name>A0A2R6QXL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="6">dUTPase</shortName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000295">
        <property type="protein sequence ID" value="PSS17132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXL6"/>
    <dbReference type="STRING" id="98765.A0A2R6QXL6"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="7">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS17132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="214" mass="23879" checksum="870D8C82E5835CDD" modified="2018-06-20" version="1" fragment="single">IPGQKGPTAEPIMVEGHEEWEVEKILSSQLYRRRLQYLVRWKHCGPDEDSWEPASLLKNSKEAIQEYHKAHPQAIRTLDSSPADQTFALLQRDSTLRVELIGGKGPTRRTNDAAGLDLYASRDQVIPSKSRALISTGIKIQLPTGTYGHIAPRSDSIVKDINTIESAIDRDFTGEIQVTLVNTSDIDLKINKNDSIAQLIVERIAVCNVEITQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0Y5</accession>
    <name>A0A2R6R0Y5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000286">
        <property type="protein sequence ID" value="PSS18901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0Y5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS18901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="10626" checksum="4030CE348F28B3F3" modified="2018-06-20" version="1">MDFRDCLQEAYAQDALDYVQALDCPAEHLQPMSHTPMSTGGSPTGSSPTGSITPSPTCSNALPPNDPLLPPSSANFWEEQRRRKHANLNRRKKKGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R134</accession>
    <name>A0A2R6R134_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R134"/>
    <dbReference type="STRING" id="98765.A0A2R6R134"/>
    <dbReference type="OrthoDB" id="3230658at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS18938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="25355" checksum="6C788DC0E7C6889B" modified="2018-06-20" version="1">MFFRVRAVFYHSTPTVVAFALLWMATVGAALTAPFALQGGIITVQAGSSVIQIPEATVQRFAVSSYAMTAVYDALVVVAITYQLFFSRLRATPASEATGVSPKPVISYLKSLIRGEGLGKMSKTLLQTGLLYYFATVGMNTVALISVISPFVPVVNSMFAPPSVAITNIMTCRVYRQVKLGVLLQYPADVDTTTTQLLSSMRNRAWGILKLGDRSTSGEDGYDHGIELSEFTSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R3Z4</accession>
    <name>A0A2R6R3Z4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000282">
        <property type="protein sequence ID" value="PSS19938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R3Z4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS19938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6243" checksum="A22756EEE246A5D1" modified="2018-06-20" version="1">MAVHPGASSHRICVNIQAMLAGKSSRSTSITANPGYRPSMPTMDNQIIQHQGVDVDQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R783</accession>
    <name>A0A2R6R783_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000272">
        <property type="protein sequence ID" value="PSS22631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R783"/>
    <dbReference type="STRING" id="98765.A0A2R6R783"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="2">
        <location>
            <begin position="92"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS22631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="914" mass="100294" checksum="82BF93CAE0914758" modified="2018-06-20" version="1">MAVVDGFEANPGGMRGLRIGIDASIWIVHSANGKEGENPELRTILFKCTKLMRKPFLPLFVFDGPYRPDVKRGKHINKAAHWMVAGMQAIFTALGIEWRTAPGEAEAELAYLNRIGVIDVVLTDDVDTFLFGATKLMRNCNNTLSGNQSFPVHNELGKDDGNHTMTYSSADIENKLGLKQGGLILIALLSGGDYHDGVRGCGPAVGLGLAKCGFGDSLLDAARTLGERDLNAFLHGWRQEICLELRTNSRKLLPTKKVALANSFPVDFPDLRILDMYVNPRTSETVGKTAADMRLNWDKEPDIGLIAGLCEQYFEWGYREMIIKRFRTIIWPYAVLRIIRRAAILADRKRTRSSDTILPSTPKKNGRERTFSVGTPSKMIKHHFSTCSQASRAYDSDSDSDSSDEQLISKIHLARRHVETDKILEYRLEIAPKQLVRLADAGIEGRRQPLDTTGLSDWEGDEDDEEEEEGGKKKSKGKTTKPPPPPDSHLRLWLPASMVAIVEPELVAEFKEKEAKKESKKAGKTSSSAGTSKAKASGATAAKTSKARTTKTKIAAIPEAEEESDEERVPREPAAKATITVLQQEPAPSKEKVAASTSKNFTAGRDAHPKAMDQFFKTSKGIRDAKKPSSIAKVAGLFASDEEITFFKDLTGKGIDPPGLPDHSNIGHSLPAKATSSSRTRSLAPSSSHPSFKASSSRIVSTQPPSLSNLSRASSSKTIPSQPPPPRVTLGTLSNGHRQRTTSPPMAPRPFPLDLEEFKLDTPLPTASASTSHTQRRLRAPASPDSEDRVHALQKSPRKSVVHDSPRSKQAASYHWQHSSVPAESDADDDWDMGRPASPSPMRPRRQEMQPKKVEYIDISSDPDTPPKPIRSKEVPPLQAPRTRMIPTSATTARLCTTTKRPAINPDDIIEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7B2</accession>
    <name>A0A2R6R7B2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7B2"/>
    <dbReference type="STRING" id="98765.A0A2R6R7B2"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="215" mass="24229" checksum="DA7CA5E2569D3F94" modified="2018-06-20" version="1">MAAYVQDAIVLLGDSLTQGANAPYGFSQQLAYTYNRQLDVINRGFGGYNTAWAIPVFEQCLTKRDQRQNAPKVRLLTIWFGANDACLPGFRQHVPLDLFSENLTKLIHMVSSAKSEYYSPETRVILLTPPPVNTNQRGNDRDFETTSKYADAVREVGKKENVPIVDVWTLLWEGCGKVEGNLTKYLTDGLHVNAEAYEVPIVPHYCMLRDIEQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI91</accession>
    <name>A0A2R6RI91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI91"/>
    <dbReference type="STRING" id="98765.A0A2R6RI91"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein CPL1-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8075" checksum="12661BEE7333FAA4" modified="2018-06-20" version="1">MAFGRNPAHGVDCTAIPGVMDVACAAGTCIVHRCLPGYVVSLDGSFCIRQNAMTQLDGDINAAVYGLEHVPLKRTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RID8</accession>
    <name>A0A2R6RID8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RID8"/>
    <dbReference type="STRING" id="98765.A0A2R6RID8"/>
    <dbReference type="OrthoDB" id="2795203at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="15977" checksum="8E817FDA2122B4F6" modified="2018-06-20" version="1">MRMDDANLKPTFSYLVSEITKRFPNFAYLHVVEPRVEGNVDRAVQHGEEIDFLREIWGSRPFISAGGYTRDTAISTAEEKGDLIAFGRAFIPNPDLPFRLEKDIPLTISDRSSYYTWESPVGYIDYPFSKEFEGGTRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIE1</accession>
    <name>A0A2R6RIE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin-9 central HEAT repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIE1"/>
    <dbReference type="STRING" id="98765.A0A2R6RIE1"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin-9 central HEAT repeats" evidence="3">
        <location>
            <begin position="138"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS29789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="858" mass="93288" checksum="DFE2FC0CAEF897F4" modified="2018-06-20" version="1">MVQDLHPESVNGAIASVFPVWLDAFKVLLNMDPRNDVENTPNWDGIAIKREVIKTIDTIRNGFPRVLKPHLPDFLTAALRHLTALFPTYYHYYVLAEDSVPNSSEDEKIELSQFASSTLDLLANVARNGGAKTWFDQSNVTALIAEVFRWAEMTTDDETEWAHDPNAFVAQESEESTSYSVRVAGFDLIDTLLDRTPALSLSTLQTNIERTVVESSQAKENGQQGWWRPLEAGLAAIGGVQSTIFESLDIEGRSGQPDPINVKQLLVDVVPNLLSLSEFPFLQGRAFVFASQFAKLLPSELAGNYLDAVIQVLESQDGSIPVKVSAILAAKGFCKNSGVSTIVPRAPRICKCIEGFVQITTADTLTLIQETLSALLSVQEGQWMTVQLAGSLIPATLNVMHKNIRDPVLMATISSILGQLAAVPIPGMYEVVISHAVPILCQAIVQPDGSPAAAIDQVCGLLEGAPQGKLGVNFMNTLAPCLFGAMKTMEDRDGIQAGISALTLIVKKDCRALVEWRDPSTGGSGLDCTLQLIATLLETKDESGSLFIGDLIIQIIRNAGDAILPILPELLQAMVRRMTSAKTATFVQSLVIPFAFLIHSGHRDTVLGLLESFDVNGRSGLNVFINTWCENAETFQGYWNTRVNSLALIDVFVSQRSSLQNLLVKGDLIIDPGTEGVIMTRSKTRAVPTQFTSIPFPLKALKLLLHDLQTEGEPASLGYMGIKESDVADLDSDDGDEEWDTEATAEALDVGSDDLTRMLGGHGVPPEMVGIVAEMAATPSMRSTPTQFERDPLYDTDGEDLSDPIYQVDLRDCIISFVRECATQNTSNFSAIVDKLTPEELMVARKAVTGEQNGSESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIL5</accession>
    <name>A0A2R6RIL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000249">
        <property type="protein sequence ID" value="PSS29855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIL5"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="211" mass="24600" checksum="D063930D5C80E75D" modified="2018-06-20" version="1">MDQQREELPRISVDSLHDWERIKASYTDAAMATFETRVASRSEADKKLLRKHLQKFIDRTFEMSTANLRINGRNFEDLNAEEQGGIEPFDEGLDRHIWSLSDQSLQWDGEIAKKRREKPREVHRLMKELLETQQVVDEAETEEYAQVVEGDDEIEADSTSSRNHPNNRNGNPWQSVTEAYNEAENVSRKTYAVAEELQQVRQHSFCLLFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIP4</accession>
    <name>A0A2R6RIP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aconitase A/isopropylmalate dehydratase small subunit swivel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000245">
        <property type="protein sequence ID" value="PSS29893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIP4"/>
    <dbReference type="STRING" id="98765.A0A2R6RIP4"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14888" checksum="918CC69547E51EDF" modified="2018-06-20" version="1">MDFGIMCVITPSFGDIFRSNMMQNGMLPIQLSSAECVALAEDAQNALELEVDLVAQEIRRCKDAPPVKFSIDPFRRYCLMEGLDDIALTLQKGRIIAEFEAKRRILWPWLDGFGYDGTKLHVDSNLNAMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPI5</accession>
    <name>A0A2R6RPI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v2275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000212">
        <property type="protein sequence ID" value="PSS31948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPI5"/>
    <dbReference type="STRING" id="98765.A0A2R6RPI5"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS31948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="380" mass="42384" checksum="74EA6FCE1AC77FAD" modified="2018-06-20" version="1">MDGFDDEEIARAIALSLQETSQVPAKSKAVEVIEIQDDSDDEVSPSHSKAATEVEVSGMRPSTSTSCAKSTSSSTREVPLTRPGGAFLFDRAQLERERLARQKRLRPDIVHNRGNEDEEDEEVEEQPNAKRQRFSPSLTSAQRANMPSSSTRSVASTSVNTNLIAQTGSAAGRSESLFWEGELRQTANKHVDLDKDVRPVFRLTEILAPRDEIEFAIVSAYVINFPWLYALFNPRTPVIAVTHDPQGNETIKEVLPEWIKTTPFLRGGRGCMHMKVLQTGHTALMKAVRDLRVRTTKGNELVLECQGSSIGTYTTQWTNEFYCSARGDSAEQWLDKSRASRSKLDYPPLKILFPSGRTVRESVLGEPVRILLFSFGRTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPN7</accession>
    <name>A0A2R6RPN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS31986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPN7"/>
    <dbReference type="STRING" id="98765.A0A2R6RPN7"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="132" mass="15035" checksum="7FCF4B1F8F8961E2" modified="2018-06-20" version="1">MSVKRTAWVPHRYPAARRADHVDVYKSKTMGEVRVHDPYVWLERNTEETEAWTTAQEACTREYLDQNPDRQNLEDDIRKNTNYAKVHTSPMMFSRPGLTIFSSSFPLLVCVTMDGGIGITTVAFKPNPVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPV6</accession>
    <name>A0A2R6RPV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000203">
        <property type="protein sequence ID" value="PSS32029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPV6"/>
    <dbReference type="STRING" id="98765.A0A2R6RPV6"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27405" checksum="D6B4215ECDC4C2BD" modified="2018-06-20" version="1">MANLATREFLNHLKSLYPQVASATGSAVVLNNPWYIIAAVAFGSSNIPDAVPIVFTHALEDLKKVQTEHSVDKETAHKEQLRLARRVREAVLKGGLLCGASRAINSLIALHAATPEDLCDTETIRDQNVTMEEYVQNGEKLFRAMYRDTADNVQGLLDKVYPDMGWFSRVVGYGITYGSTGDLLSQVEVSYILVAALISMDTPRQIAWHLANAQHGGATLQEAQAIRQITMEVAEKSGIRWKEAVPNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVE6</accession>
    <name>A0A2R6RVE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000175">
        <property type="protein sequence ID" value="PSS33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVE6"/>
    <dbReference type="STRING" id="98765.A0A2R6RVE6"/>
    <dbReference type="OrthoDB" id="2499463at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS33976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9556" checksum="0530DB7053F9E2B8" modified="2018-06-20" version="1">MRLKYGWNLNPKGFQLAGVQAQLEGIDMIIQAATGSGKTAIAAGPHLWIEGKQSIMVCPLMTLEDEMLVKDILGLKYQINLISPEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZE3</accession>
    <name>A0A2R6RZE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000134">
        <property type="protein sequence ID" value="PSS35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZE3"/>
    <dbReference type="STRING" id="98765.A0A2R6RZE3"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="317" mass="34381" checksum="A95A4FEC43D49F23" modified="2018-06-20" version="1">MDSSELYHVKQQFVLGAYKTLVDLTLPDPSSPDYSPILIYQARAHIALNEPSSALSLVPSDSENIALKAVAALARYVDAKQEAQKDATLEELRDLCVEVEGDDVEGDERDKWLVRVLAGTAFARADEVEEALETLGAGTNNDNLEAVAVTVQVYLSIHRPDLAKKELERAKRWAEDDLLLQHIEASINLVTGADNYSDCNSFYTEQLANPSLTSPHLLTARGVTRLLRGEVSAAKSDLEEAVSQQGGTVDAETLGAMTVAAGLSQAKQNEADAEQLWSRLSSQYPTFPLVVDLAQKSTLFDELAARFEVPPLAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3F5</accession>
    <name>A0A2R6S3F5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3F5"/>
    <dbReference type="OrthoDB" id="2159328at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="377" mass="42173" checksum="BFD860DDE218FF3C" modified="2018-06-20" version="1">MPCPLLPFELLVSVLEMAFDDKESVTLQNCALVCQTWRDVARPYIFRKIKITDESLLVAFEALINADSTVGMLVRKLIIQPRTQQERTPSSWISGFPAVLPSYLTRLQTIQLVDFYDFGEYCDEGFFLAFSGFASVDRLILCHCSLDLHLIYSCASALAGLHHLHIGPTSPLPSLLSDPPPQLHSPHLVSITLDLGIMYPMALQEVLEWIMASPSKETLRSFRVTTRIAEAATVGNFIRELGEIIQDLDLHFEQSFDLQFEYDLIKADISLSYCTALRSLFVHDSNPTLPAFIALLSEVSSQHICSLSLQVLSEAEDPAGLPDFGLLAGQLDSYHLSTLKEVCFVYRGPLQRAVVLEKLRQDLPNTDTRGILRLIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3H2</accession>
    <name>A0A2R6S3H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000106">
        <property type="protein sequence ID" value="PSS36828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3H2"/>
    <dbReference type="OrthoDB" id="3237371at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="237" mass="25949" checksum="EC41AE930DDA33DB" modified="2018-06-20" version="1">MVVSRTKQKLCDFRNGMGLEGVTNACEHMQEKMAAGKESNLFQTINERKAYVEELLKGDAKSGMPFVYSRMKVTASGTVEYQGAFQSPLVLKTFAWHLALIGEPGARDRQAGALALCATAVERGLRMWQQGEFDAAFPGTFSEAACGAKSLEYLHAITKNLTDNTWKVILKRAAKYNKGKKNGPTINALLDVRAESARAHIVDIPNEEYIDSDSEESEDVFSVSTTGSIGVSLSQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3I5</accession>
    <name>A0A2R6S3I5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000102">
        <property type="protein sequence ID" value="PSS36832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3I5"/>
    <dbReference type="STRING" id="98765.A0A2R6S3I5"/>
    <dbReference type="OrthoDB" id="2986975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="285" mass="32073" checksum="8537EBB310A3AE1B" modified="2018-06-20" version="1">MERSIAIGKEGGEGHCAGITWGGVNIILCGDLHQFLPVAQGPQEFLFYLIVLGNTTGDTAIRRRLYEEFNIVVILKEQMRVTDPVWRDMLVHLRRGKVWQRHLTMLRSLILGQGSRAAALDFHDGSWVHASLVTPRCAVRTLWNKNGTCKSCTKLGNQLFLYTAEDHMFNEGESWTELNLPERYAVANQSKTNYCRHKKDLPNIIKLAKGMTVLVTQNIETDLNLTNGSWGIIVNIILNEDEPPLGTEAVVRLKYLPAYVLVKMARTRASKLPNLEEGVIPVEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3M1</accession>
    <name>A0A2R6S3M1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3M1"/>
    <dbReference type="STRING" id="98765.A0A2R6S3M1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1228" mass="131435" checksum="9271DD7E5867C508" modified="2018-06-20" version="1">MNKNPFAVVPSYTPQQPPLPPGPPPPPPTQPDYSAYWAAAASAAQVQQPAVPAYNPQWPGPQATQVVAPRPTPEQTALYANYGYGGQQWQQHQRQPQQHFQPPPPVVQPPPPPPQPGYNPYQPQAGAYPQPYVPQVGPHQQVAAQPQPPYVPQMPGGQPFQQPQQNFFPQQQQQQQQQQQQQQQQQNRQPNRNMVHHTPPQHLPPAKRQRFDGPNQHRGPPPPQPQFQAPPPPPLQQTPSGPIGGGVGVGVGGINAYGPGQGQNQVHGRGGGPGVNHMPLGGNRGSFMGGRGGNVGGRGRGMGMNRGAPRGGRGGMYNNNMGGRGGGHNQGGGSFRGHGPNRGFGNRDNRRGGSFNAGGGQSFSHGHQQQQQQPQQNFSGTFRRNQGFSASVRGGRHDSAVPHGPKDSAVPSGPSSSKKEENRRTLTDFKIVGLEIQDLAWCWGTVPKASIEPVVKEEIEEDHVAAPLPDAQAADENTGVEVESAPDVADLTPKASMVDQPAVVDGVDIKTETQPVTLPPPPPSRIRIYFHTPVTADDSHPLSSQSSLSLVPSSDPNMRKGKRKKLDDDDGDIEDGRGLPPPPPQHSGTEEEPVVAPPHVGFDGTDMAMERGSVAPSAAETVSEGDWLMAAIEDEGDVEAERQEEHMHDIDSDNLHDIDAEGEPDDYGNDYDDEDVQIGMDDDQTHFSLEDGHSASGPSHGDGGGDPGLGAPGAPSSDHAQLNGFKGSIDMLSPSAPPAENSLGALLLDSAESSAAVDPLAPTTVNEPVAPSTHSTIDSDRSTQVSSDAEPRRAGAPLQAMDSVASITSTVPDTDGRLVSEPTLILEDSQGEGDFDFAMEATQPVEEQSQSADELGRLIGQPTQSADQPNIFPSDHVRPIQESKELEPELPEHPPSPSAASTTHPPASIPDTSSGSGDADIPLSTVKSEESSGKTPSANRLSISYAAGTRRMVIDAHVVEKLQVFRSDARIEVHMNITRDDGQFKGILFEGSKDSSTSYTSLDISTASEEDATLPPFSKATLPTKTVLTIYLDKDKPLSEPRWVKTGDVQEWLKSMFGRMFWVAGDAADGWEKKIEVADPDPAPTIWTILEAWAINTNVGTQTERQRFLRTHMTETDNILEILLRLVRGERATYLQSTAISAPSVSGPLLSALSQGSAHGAQQTHVSLAVLAIVRLTVEFAKKAAGEEGKIEAEARVGEIIRCLPSHLIYKSLDGIFKEWRVEKKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4W3</accession>
    <name>A0A2R6S4W3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000066">
        <property type="protein sequence ID" value="PSS37302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4W3"/>
    <dbReference type="OrthoDB" id="2798374at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="80"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="17999" checksum="5E9E97BC8AD41CD7" modified="2018-06-20" version="1" fragment="single">AFRLVEKGAFRRLLQYQRPQTKDTEIPHRTFVREEIMQKASDVEAQLREVFKDIPGQISVTFDAWTSKAYDPYLSVTAHYIAHSSQYPVLSRIARDYLAIQGSAVASERAFSSGGRTGTALRNHLASATFEALQILKSGYWDGIVSAVEAVAQAAKESSDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5E5</accession>
    <name>A0A2R6S5E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5E5"/>
    <dbReference type="STRING" id="98765.A0A2R6S5E5"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46683" checksum="25E066C4EE1CE13A" modified="2018-06-20" version="1">MKSFTKSPSRIWSLCGVIYEERVGSDQIEMDVRDREQRKVGFAGPSMFAKSKAFSLAERRHVSFSPDAKLFGIEELFEYLCSADGRRYPISEIDLHTTGVGDRALSKIARYLESNTTLKVLSLQHNDFGSQSLEAVSSFVTAINQSRLRKLILSSFEWGELFVPHILDNLNTPYLHELGLAMTGLSFASAPSIVAYLTSPRCNLKVLRLSANKLGYRGMRHILYAMEHNYSLVILELHGNLMEEGDLEEDNPSGLLSKWRVLIQKRNAHFQMVVEIEALSLLRHSRILLLGHEKLETVPSPLHLPMELQLHVLSFLAPSLSESQRLRVFNYASSTSTLPPLLPPLIGSECLRDPAALPMFPGGLVGTPAVGACESGKCMGSGNSVICRRETARSEWLMAVGCHVYIPEPSTLLTLAADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5J9</accession>
    <name>A0A2R6S5J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000039">
        <property type="protein sequence ID" value="PSS37532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5J9"/>
    <dbReference type="STRING" id="98765.A0A2R6S5J9"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="393" mass="41033" checksum="F27F999809732892" modified="2018-06-20" version="1">MKAGSVRRLNVALAISAGLQVVFGSNIIVETPLRAVVCTPLDITWQGGTALYEVEMTVNGNLDPLQIYSDIPDTHFIWSTDAPIGSAITVRVFDSLGNSNTSASFPVQFGSDTSCLAGGVVSSATSSIITSATPSSTVSPLPPPSTSGWSSSSPFGTPSPSDTSLASSGKTEPPASPTTTTFNDSDINTSRKHKTAIIVGVVVAVVVAALLASLAILLVRRHKRNAISNFADPVEEEKSISPSLTGDDTVQASARGSSPSEIRMLPTELAGTEMAMNVIDPSAPPQSAFGSIEGALANDNPSQSGLTACTNFKKPMDVLFNRDSMAADVGFSVLPRDIVKTRVSKQTHLRHVYPLFGFRIPDGKSSALNCTLKVGSGPQILAPTKTYTELPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5L7</accession>
    <name>A0A2R6S5L7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5L7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5L7"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="247"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="534" mass="59896" checksum="B77FB495E678CD90" modified="2018-06-20" version="1">MGPLVYTPVEDIPKIHEDLRKGFRSGKTKSIAYRKEQLAGLAYMIKDNTERFQDALKADLGRPPIESDLLDISAALSEAKDAYDNIEKWAKPEKARWDFNWFAMKPTIRKEPKGVVMIIAPFNFPMLLMLGHLASAIAAGNAVLMKPSELCQATNQLIADLVPQYLDPDLYRVVNGDVPVTTKVLSHSHVRLAHLFTLFLNLQLLELRWDHTTRDYGITYNTSIRWRESRQNCLRSSSQAPYTSYYRGKSPVIIDPKCDMKLAARRIFWGKIANAGQVCVAPDYVLIPRDAQDHFIQEVQDIYKTFYPTDPATSDSYSRIISEGHTARIKRYIDETKGEIIIGGEVDVGKKYIAPTVVKNVPFDDSLMDEEIFGPVLPIVPVKDLDEAIEVVNSRDHALSLYVFTQDPAFKAKVFDNTQSGSAVANEVVIHVGATGLPFGGIGPSGSGYHTGKYGFDVFTHHRGTLDNPGWVDTLILKGRYPPYTPEKIRNLRKAFNVSMPPRPGTKAGKRWGLWLVFALLGTISAVLMKRKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6J8</accession>
    <name>A0A2R6S6J8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6J8"/>
    <dbReference type="STRING" id="98765.A0A2R6S6J8"/>
    <dbReference type="OrthoDB" id="3364141at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="28058" checksum="110B4E236D5E741F" modified="2018-06-20" version="1">MSTLSYPTYMHPWFRVPSQKRRASEADSSSSASDASDVETCPRAPKRRKCDVLENGIAHLSLNTQLNSPIVSSPSVSAYPGTPSYDWSPSDTRSTVGAAAQVSWNSSSAAYNGPQAVGPVLRPGSVEEPPAPEVPDIPEVTMRGQSWYEPEKDRIVVTDLDDSDAEDSPDDPFGLSVNSALMDRIKSGSAPLAPLPIPDSSKALVLFRPLAVPDSSRMALDNKARREKDQTDIVEDIVEDIFVDPPLVDDDDAMDIEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Q3</accession>
    <name>A0A2R6S6Q3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Q3"/>
    <dbReference type="STRING" id="98765.A0A2R6S6Q3"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="132" mass="15303" checksum="5A6F889B1F70572C" modified="2018-06-20" version="1">MSLLRTALLRPQRAPFSTVPRRLASSEAHDEHHDDHHHVEDTTVYPKEDFSSSIWRNAIVFGLVGAALYKYAPSSEDPILTRFISHYSTPKTVWEDLNVKHLLQTVENQIDTLVIADARRPPVHRYRYPQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Q9</accession>
    <name>A0A2R6S6Q9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Q9"/>
    <dbReference type="STRING" id="98765.A0A2R6S6Q9"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="63083" checksum="788BBC190C74CB0D" modified="2018-06-20" version="1">MHHLSNASSRALRRAAAKTVRSQPALSRGAHKEIKFSNEGRASILKGVDILADAVSVTLGPKGRNVIIEQSFGSPKITKDGVTVAKSIQLEDKFENLGARLVQDVAQKTNEIAGDGTTTATVLARAIYSEGVKNVAAGCNPMDLRRGSQAAVDRVVEFLSSHAKTITTTAEIAQVATISANGDVHVGNLIAQAMEKVGKEGVITVKEGRTIEDEIEITEGMRFDRGFTSPYFVTDVKSQKVEFEKPFILLSEKKISLLQDILPSLETAAQARRPLLIIAEDVDGEALAACVLNKLRGQLQVCVVKAPGFGDNRKSILGDLAILTGGTVFTDELDIKLERATPDMLGTTGSVTITKEDTIILNGEGSKDAIQARCEQIRALLADPTTSDFDKTKLQERLAKLSGGVAVIKVGGSSEVEVSEKKDRYDDALNATRAAVEEGILPGGGVALLKASLMLASNAPGASGLPTAPDAKTVPTANFDQDLGVQIIRRALTYPARTIFKNAGEEASVIVGALQQTYGTPDKFAWGYDASKGQYVDMIKAGIVDPFKVVRTALVDAAGVASLLTTSEACVVEAEDKSKPPMGGAGGMGGMGGMGGMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7F2</accession>
    <name>A0A2R6S7F2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v26</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7F2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="14182" checksum="3D49603434544E76" modified="2018-06-20" version="1">MADHISALIGIVAFGLHVAHRVYEVVEIIQDGPEDIASLKHESYDIGYLLLHLQRSDILQDRGSHPQHQDEQYISGLIERSKNALEEINRFVEKMTKKSEGGQVNRPSPSAPRTLRNQFSKQPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDN7</accession>
    <name>A0A2R6NDN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase rio1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PHLCEN_2v13625</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDN7"/>
    <dbReference type="STRING" id="98765.A0A2R6NDN7"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="23">
        <location>
            <begin position="190"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="543"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="591"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="19">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PSR70474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="643" mass="73264" checksum="87811033CABD3792" modified="2018-06-20" version="1">MPAKDNETPIEEGQFDDAPGDASNPTQDTTDIRAGHRYIDEEQENILEWSSESSGDEEELDEFDVREDDMEAAAFENLRAEDEDWEIAERDFTKQYNRLRQHVAVRTGIAQGTSSIVNGTTAVASLPAINRPRPAKQVVASGSSHTRDKTENQLQALSKYSSRLRNLDIPFNLGVGVNRKGPSATANMKDKSDRATTEQVLDPRTRIILFKMIGRGLLYEVNGCVSTGKEANVYHAVTPERKHLALKIYKTSILVFKDRDRYVSGEYRFRRGYSRHNPRKMVRVWAEKEMRNLKRLQGAGIRCPEPIEVRENVLVMSFIGDAEGWASPRLKDADVPASEFSILYSELLLMVRQLFHDCKLVHADLSEYNILYHVEHPPTTADDSQLPQPSDSLEPEKDNDQRGHLYIIDVSQSVEQDHPHAFDFLRSDLRNVEDFFSRHGIRCLGLRRAFEFVTKESHENEGGNVAALEKWLEESEKDDNDESTEASADVNRRSAADEDSVFMRSYIPRTLNEVYDPERDVGALNRGEGKGLIYKDTIGIIAPKEKDGDDDNGGERRVRFEDEKEQGSEDETSEASDDEEEEEDADDSDDRFENGKPRGHRHEDKDVKKERKKAVKAEAREKRKHKIPKAEKKRKVKTTARGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDP4</accession>
    <name>A0A2R6NDP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDP4"/>
    <dbReference type="STRING" id="98765.A0A2R6NDP4"/>
    <dbReference type="OrthoDB" id="3199367at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="200" mass="20798" checksum="88195A1BB06C832F" modified="2018-06-20" version="1">MFSLQTSTILAALLFSISASAVPTTSFELTSISSVAAVTSVTSLAASSPSVSVTPVKAPVTSASVPVTSAISTAAVASAVPTSGASIKNLQPHQFDVYTPHITSPKAAEIWRVGENHTVTWNVASLDPQGLNTTGYLLLGYLENDSENLDIQHPLAHNFLLGDGTVDLTVPNVTTRDDYIVVLLGDSGNTSPTFIIQNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEB8</accession>
    <name>A0A2R6NEB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEB8"/>
    <dbReference type="STRING" id="98765.A0A2R6NEB8"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15567" checksum="080EEE421409BDF2" modified="2018-06-20" version="1">MAKVPRNFRLLEELEKGEKGIGDGSCSYGLEDGDDIMMSHWNGTIIGPGHTVHENRIYSLKITCGDDYPDRPPTVQFISRVNLPFVNQVDGKVDQSKLPVLAHWNRNSSLETVLVEIRREMASFNNRKLPQPPEGTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEN0</accession>
    <name>A0A2R6NEN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEN0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="11178" checksum="9604907A6BB2FDB5" modified="2018-06-20" version="1">MAPTAPCELALFGRRADAALADWDDKADCEGKTDCDGTTDCDGKVDCDDMVGCDGMVGCDGMVGCDGMVGCDGMVGCDGMVDCANVVEMIGIRDRVMELEFGGDTTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF05</accession>
    <name>A0A2R6NF05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF05"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="132" mass="14942" checksum="6201FBAD8929FBBE" modified="2018-06-20" version="1">MLACKGSFVRECGVWRQPWTSREAWTLCTRCLSRSSTRTLYPSKRSAEVVQRSELALKGVVIPATAADGRFPEYDERTRKQTRLAIRASCEASSSVASSEGASRLKYYPQSERKYCAVRNVRSSRTARKLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFE2</accession>
    <name>A0A2R6NFE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFE2"/>
    <dbReference type="STRING" id="98765.A0A2R6NFE2"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015306074" evidence="1">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="12776" checksum="C99B1A5908122FD5" modified="2018-06-20" version="1">MIPPVSVSLLFCPLVRLVTLTDAGSAATSPTVRNVLATHPQLRDVLYSIDQLRGEDRNDALQRALGVSASDLHAHSRPGLARNVTQPQEDTRALRELAEAIEAAVRGGKEDALGLDWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFF5</accession>
    <name>A0A2R6NFF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001331">
        <property type="protein sequence ID" value="PSR70732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFF5"/>
    <dbReference type="STRING" id="98765.A0A2R6NFF5"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="11331" checksum="DC4ADB4EC33A156E" modified="2018-06-20" version="1">MSDTGRQSLTDKASAALKVSLPRNSHAPHFDTNFVYLKPDSEKSTTEHFGDKFKGNADSLGSSAQPSSEKSTTQKLGDAVSGNSNQGTEPSMAQRAKNAVGLGDNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFI9</accession>
    <name>A0A2R6NFI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001296">
        <property type="protein sequence ID" value="PSR71028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFI9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="121" mass="13287" checksum="209B8F7B66C06A17" modified="2018-06-20" version="1">MVGFLDIAENEWDDAILRIAGIRQSRGAVVNVVDLAGSCGNPPRGLRDRLVCCRRVGIVGSSSANYCPEKKEDERHGVISSADKSPKKAARFKSGLDVLVGDEHDTRRKYNQGYACHNIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFT1</accession>
    <name>A0A2R6NFT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFT1"/>
    <dbReference type="STRING" id="98765.A0A2R6NFT1"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="11073" checksum="169E92BA6DEFEE6E" modified="2018-06-20" version="1">MDAYRSAVSFSKRPDFSQHMVTRAEYLEMGSNASRRKFRDWKPLDNVKGRETAKGRAVRFDQELEEGDEDLAPRKRGRGRGRGAGVGEGGTSRRRVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG45</accession>
    <name>A0A2R6NG45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG45"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="146" mass="16308" checksum="F774FCDB3D7E8613" modified="2018-06-20" version="1">MPPHPTSQPWDLSYPPAPSSEQHGEEDLKAPYDDLIDQYAIPYRQNPTHKAYAVDPSAFESDDLSQKPSRTTEASDKDLEYASTDGHNWGYPPVAQKEKRERGHWWSAVRLDLLQVPTMPEQTPTDNPGFNSVSLVLVDGTSGDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGN0</accession>
    <name>A0A2R6NGN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGN0"/>
    <dbReference type="STRING" id="98765.A0A2R6NGN0"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="282"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="741" mass="80490" checksum="FED634A81240997D" modified="2018-06-20" version="1">MVVSPLDAEDVSKVVKFCLKHNLSPSVKAGGYGIAGWSVAGDVIIDMSLIRHVDIEPPIPEEEGGCRWTPLKDMPPPGSKGKGKASEVKRKLEVVAIADPPQKEATSMKRRRDDRGDSSTPIEKVPAYGPTDDESRSRVYDAASYAVGAFFRGPPLPLVPGETPREPPRNKRRIDSPVPENSTDVVHHLPLLESKQLSSESSAGGGSTSGSAFGFSTERTLSTETAVTTPTDTPLDSADNALASVAESNITPTAATEPFGYMSSGPPASRPPMYTGSEPFAYMSSASTVLTPSNIPSSWRPPAAVSWTGPSINPSAQGSSSAMLSFMPSLPSMPGTFALPQSHVGNVAPARPVYDHAYVTFGAGMRQKEVDTFTAENPLEGISSASGLREEGLVPYHIPTSAHPVGSSVMILSGFGFLSRLYGLSIDNVVEIEMVLADGRIVIVNKDDDPDLWWAVRGAGPAFGIATRYKAKAFPVPVCFAGNLIYRFHRATAPSLIKHFRDCIKGAPRELYANVLLTAGPADKDSLVVIQMCYLGPKEEGMEYLKAISSWDGERCLLNEVNEKSFLYQQDSVAQVLRGKPGRQWFLRSSLIHSLPDEVIHKTVIQFSNTPIGCTWIFELSGGAIADFEDTCLPKEQREAIWTVAALHQWDMGIDDPRCITTAEEWMQEIIAPVSVGGPYPVFLGRHEPPSRTMACYGKNWERLAALKRKYDPDCLFRNNFWPLDKDGKPVEPLYNEPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHK1</accession>
    <name>A0A2R6NHK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001237">
        <property type="protein sequence ID" value="PSR71865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHK1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="570" mass="63381" checksum="EBF6620E48F1FDE7" modified="2018-06-20" version="1">MVDTRPSNATAHPGQVQIEGKRKRRTAAQMKSAKEAKKAAETAAKVLDVEKAAQQELLLHRIAELENKLVEGRAAARPPPPIRANLVLQNPAKGGPSASQDTAKDVKTVTPANKGQSAQPYPLSQPRTKYSRAEIATMRAALSTPTHKGAGVKAKMLVIPGQQAGGSGKRKFEAVTIGRQNRLSIRGFAKSYSTTALSSKGKGVEVNEEHTEGLSGTQSTGSKLANDDKSESAIDDFNDFSDGEFNEGEVKFEDEAIIISSDDDGEGGNNVPGRQLLFGHRMTTEGMVHIVDDQSSEAGSLDKIRPWPRLEDRQPAPTRKPVRSDLPIPYDQHKKFVKIYIRRVLRWLGEQPATFNVAYIDLLRPMQDAWDLTFPDYPHQIDFRGATYNITLQKTYDWRSAIGRSAIEILIAYLKKRTDLATDVDRTIWVEEMVKKGNKLPFLYARTEKMPDGNIERAITGFRTGQLAKQHMRFGYLYWGKTSLKYLHNTKTRVKPSSWRAIIIRARRSIAPAAAHAEFKEITCNLPDIEDDDYVLDDYTDDEWEGEDEGAMGMAMIVDVEGGEERTADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NID7</accession>
    <name>A0A2R6NID7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NID7"/>
    <dbReference type="STRING" id="98765.A0A2R6NID7"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000899">
        <property type="entry name" value="Chromosome 15, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="603" mass="66011" checksum="E23B18385AB2ED3E" modified="2018-06-20" version="1">MPDAFFANPKPRKRKRANGDNGPSTSKKPTRSAGKSQNLNGKKKAVSAAPKSKRRDEELSDATQDEDEGAGVDEMDLRAPDVDPNAYESGEEDDEETPAEKRLRLAKLYLEGVKENLGLAEGEFDAAEIDKEIISTRLKQDVMEHSGKVHLFVADSYDLSNPPTLRTRGHRFSATSAVASEDAHWLYTSGKDGCIIKWDLHSGRKAHTFFKLRSSKEKGKGKGKEKAEPIVDLHGHSDEIWALALSPDGRLLASGGKDKRVGVWDVEKNEWVKGFGGHRDSISALAFRRMAASSSTPIQLYSGSFDRTLKIFDLSVMGYVETLFGHQAPVLNIDSLMRETAVSVGGRDKSVRYWKVPEESQLVFRGGGRSGWEDILEGADVEDGMDVDGEQKAKKRGTGKKEKFIEGSIECVAMIDESTFVSGGDSGSISLWSTQKKKPIFTQALAHGMDESHVETEDMDIVRKPRWVTALGCLRYSDLFASGSWDGEIRLWKLDPKLKSFSLVGSIPALGVVNSLQVLSCPSSTVAQLSWTKSSDSHTDGDVQMNGQKTTASRVVTAAKSMLLVAGVGQEVRFGRWVQKKGEGFLNGALVVALHPRTPSSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIM8</accession>
    <name>A0A2R6NIM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIM8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="244" mass="27914" checksum="522ABE92D7A3C3AD" modified="2018-06-20" version="1">MPLLQSFFSDNLTWPDGPLPLHPSETMHVSPALRHIECRYQPRSDFSSLPWLFLSDPPRHSYPEDIVFPLIESHELSNICTFMQTWAATSLPFLEPWSNDPPPPRPLYNPVMTLERDRKSEEQLPERWYLALKYDLQGVQPPRLRAKFFLCAATIAGPLSVQRIHTELPVLLATSDTSLGSQMKKADELSLQFKQLTEYRVLLRESARSSEKEVSQAVQAVRAQMALTERAGKLLVAMVRSQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIN9</accession>
    <name>A0A2R6NIN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001209">
        <property type="protein sequence ID" value="PSR72161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIN9"/>
    <dbReference type="STRING" id="98765.A0A2R6NIN9"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="242" mass="26411" checksum="89CC685655E285B6" modified="2018-06-20" version="1">MGTKRWDGTPLYVGYKATITGKEIEVDGSIKQSQMPTIAGKSTEYENELEFGDPPQSQAQTSFLLDHWESPGVDVKREPAQSPAPISGPSAKKPYVAPSSFYAHKPAKPKVAAPLHNPNDEGAVTMPSGTGAHHAKYNKKNAPVVPVVIDPIVARRLRPHQIEGVKFMYECVMAMKGHDGKGCILADEIRSRWYGPCSVSDSLMATLLTQEHRTEQNPYWGIGPTVGKVLIVCPVTLINVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJM4</accession>
    <name>A0A2R6NJM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v11546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJM4"/>
    <dbReference type="STRING" id="98765.A0A2R6NJM4"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR72553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="48801" checksum="1EFBC37CB285D4B4" modified="2018-06-20" version="1">MDVAARVSAARRYAVQLMVKLLCDDTFLYNAGEEGSCAEVLGAAAWICGEYCGELTEPQKLLTYLLQPMVLTLPPDIVAVYLQAAIKIFGSWAAELADRWDDADLPKVKAVVDSVTASLSRFASNTDIEVQERAANTLQLLAFIRADLTAFQPRPQSAYDFGEAGASDFGIEASTEPRFPKSLYLIQPLFSSYELNPVALAAQAYVPIPEGLDLHAWIVPPPKEDVEDAVDAENNGVEPKAKKSKKGKGKETSANKVKGKKKKEIENGHPEAVVASATETEEEKAERQRNKAERLERMRDDPYYLTDNRASSRLQDDIDSIPVVRLDDLPPLPPPSAENSRLPSLRNTLRTKSPQPFVIDKVGEMPEGVVPSSPAPPSATTSVWNGAAAIPSPIPPLSSFPAYEIEDEIPRMGTPPPIKVTRAKKKPKGPGNGSGKKKRTTEENNSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKS7</accession>
    <name>A0A2R6NKS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR72995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKS7"/>
    <dbReference type="STRING" id="98765.A0A2R6NKS7"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="13679" checksum="CEB05CC4619A8005" modified="2018-06-20" version="1">MSSDPGFESGIHIRTPVRPSGGALSKNQTSVNEAPSSTIRRVSCGSCDGGESGAGERLERLLEMSGCENAVVVVYRWYGGVPLGSDRWKCISGVAKEALRAGDFTGEKMAQKPHVDNAKEKRARRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKZ4</accession>
    <name>A0A2R6NKZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001116">
        <property type="protein sequence ID" value="PSR73060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKZ4"/>
    <dbReference type="OrthoDB" id="2751409at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="875" mass="98018" checksum="F0CB0B69A3C19575" modified="2018-06-20" version="1">MKRPLVDFVFISQSCFLLGKTREDSNAIEVYSMEDKIVMRHPDGGFSPVHIATYHLPPCRKGVSPCIQDFYWSFCSKLSDNACTAPFEAAPSSAMLQVLLVYLIEGREVGRGSFFIPGQVFINVSNTYRMQNGTGPVSLPWESWGPSSTRSDPDQWGIRAMYGSRVLASNYGGFIPDILLDFNQVDIARDLNRQQLTATGAISPSGSNLTLEVFSEQAELPDCSAIETDPTIIHDEDIFVDDVVTRLPFRRTKIACVGPIPYWVFGGDPWISGFHRNVNISKQVKAIVDTIPELQYKIELHVAGFMDNTQYPGNVSERLRLLREVQEARKGPAFVLDANVGSIELRPLPRHLVRYHGDVFIYYSGKVPLRWQDGIRYYSELKCLHVQSAPDGPITKKWTLAFDFSFVTHAADPGRNLLALVTPEIEGFTLRVCSLLDGNILKKIFLPHLTIHNVILWSLNIYSLHICGDGIGLAVMMPSEGDAEHVSITTLNWKTGVIMRPIECPNTERPLFVFAFISESCFLLGNTRPDSNAIEVYSIEDKIVTRDPDGAVSPVHIATYHLPPCRRGVSSSIQDFYWSFCSKISEGITRITPFEAASSSALLHVSLVYRTQGRDVRYYSYFIPRQVFANVSNTYKMQNGTGPLSLPWESWGPSSTRSNAGQWGILAMYGSRVLTCRYGTLDPEMLLDFNQLDIARDLNRKQTAAAEAVSPPGSNPNSDVFFEHAEHPDVSAIETEANVIHDEDIFVDDVVTRLPFRRAKITCVGLIPFSAHGGDPWISGYLDNTNILYYRASGGRNCRGRAMMHLMCRRISIRPPQVEHSWEYGILKSTVRQIAETESSQSEVWILSPSTQGHSHFSLAANQSHRMTSLLQYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM60</accession>
    <name>A0A2R6NM60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v10769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM60"/>
    <dbReference type="STRING" id="98765.A0A2R6NM60"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="42"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR73477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="175" mass="18847" checksum="03090E5F8A4954EA" modified="2018-06-20" version="1">MSEPVTDEPQLKKRKMSPAQGEEEKTTLAPVSNLLIKKHSEKARLPTRGSPLSAGYDLYSAEQKVIPARGKALINTQISIAVPAGTYGRVAPRSGLASKFMIDTGAGVIDADYRGIVYVLLFNLSDKDFQVEEGDRVAQLIIERIYTPDVMEVQDLDETLRGAGGFGSTGGHGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMB1</accession>
    <name>A0A2R6NMB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001070">
        <property type="protein sequence ID" value="PSR73530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMB1"/>
    <dbReference type="STRING" id="98765.A0A2R6NMB1"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="76150" checksum="4A412803B2B1EC08" modified="2018-06-20" version="1">MFSIIPHWGSGSGSHLPLPVLVFAGISTAFVIYCFLDLLIGYLGGERSLLNSLHGRPPKYQVFPGSLFWREVDVSDPYTFLFLKRGVLQYVQVKPILALVTIVLKATGKYNEGDLRGDSGYLYVSIVYNFSICMALYCLAIFWMCVSEDLKPFRPMPKFLCVKGILFFSFWQSIIISILVAAGVIRKLGPYTDNEHISLALTDALVCLEMPLFAIAHQYAFSTVDFVDPQAKYVARMRMWAAFRDAFGLKDVVEDSKATLRGEGMDYREFEPSEGFIHQGAGRDRRIRAGLRYSQGGKRKYWLPQPSTTTRPPGNMERRVNRAIERVTGRDDLDEEIYAPLLSDQADNVVHLAPDLRPPTEEPTIYSVVNLADEGYELPFGDVDPGDEELFSQSKSYLFGDYNYPVVDVSSEAARMRIWDEEERILRDERGAYFSPILGPGRLLGQGRQGYGAVGNIPRDFPRKRNDSNLSDSSRYKGKPRERSSTPVREVIIDKEQDRVPDRGSSDVQLRWTKLGGQGSAKPARIRTLSNQAGSSSSGSSSLNSSTASSPRARPPPSPRRDSERPELPPDAVDLMVEDPHATQEENAHDRRKGDPTALRKVYRRGYAVDDVGGRKEGEVEIDDEPNGLFTVGDDIDAVMEDEQEAAEEMTITRAETPPAHARIVVDHYHVPSEDNPWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMG4</accession>
    <name>A0A2R6NMG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL12 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10493</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMG4"/>
    <dbReference type="STRING" id="98765.A0A2R6NMG4"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="12225" checksum="DF715201A26AE32A" modified="2018-06-20" version="1">MPAAAPAAAAPAATEEAPVVSAEVLQCCRSLIVITSQEKVKEKTVFNVKLESFDAGAKSKIIREVKTLVPGLTLIDAKKFVESAPKILRENLSKEDAEKMKKTFTDLGAVIVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMS3</accession>
    <name>A0A2R6NMS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMS3"/>
    <dbReference type="STRING" id="98765.A0A2R6NMS3"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23303" checksum="F15DE4031CC448C9" modified="2018-06-20" version="1">MAYVSIESDDRMEEGPEGLQFQSFLGTDAREAGPGLGSNVSRGYIPDRPVKTGGFWTVEYYQPYFDVDTKTVLRRCYSTLIPKSPSYISDHLSPADLYGPFWTLTTLIFSLFVFSSLASSIAAYLSDPDASSPTDPIEYDFGLLSTAVGLVYAYGLGVPVLLWLGLRYLGVGEWSVIEAIALWGYGQFVWIPVSSPQAQPVGIPGKPTKCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN75</accession>
    <name>A0A2R6NN75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RPAP1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN75"/>
    <dbReference type="STRING" id="98765.A0A2R6NN75"/>
    <dbReference type="OrthoDB" id="3270105at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="19035" checksum="69BE921F891E9B19" modified="2018-06-20" version="1">MAQAPSLIGSILERKPGIQSSSSLPRSTGKNGFPAVQHRSKSAFSRGRDDLKKSNLSGRPQHVPKVISASIPPTDVVEQATPQAESNSSDDWRYQIEDENRRKVEDMTEEEREEDRREILDRFGPGVGDILRKAREAREAAQKGSGPSSERKVLRSTFENLPSQRVWIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNA7</accession>
    <name>A0A2R6NNA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001052">
        <property type="protein sequence ID" value="PSR73880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNA7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="112" mass="12547" checksum="D13AE947290A730B" modified="2018-06-20" version="1">MQGQYDAIDQRRGEPAAESVERSYRIVVCNIKTVKINVGDIDARTGRKVEITCTLDGLFIPEESPRPVWKTTSESLVRTEDLSHTDGSTGMENLHQVHRLKRAQALPQATLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNI4</accession>
    <name>A0A2R6NNI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001053">
        <property type="protein sequence ID" value="PSR73868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNI4"/>
    <dbReference type="OrthoDB" id="2797351at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41588" checksum="55D3E6C0AC9E14E6" modified="2018-06-20" version="1">MSFCLKRNVPTNADDEYANKRQKVASGTSHPVISTTSGLLALPVELFENICDELLIGLRPITREDTIFSSEYLKGAEFTSSASLLRPLVQTCRALRAAYLARYYEHIEVCICRHSGVHWYQELSRRLQKISEGLIGFPALAKHVRKITVSLTSCDADTVFPLFARCLSQLPNLHTLRILFTPSKMTTPLRDAFSQYKYPQIRTIILPSCAHAILRSCPEVRDVTCNSNKGSTLLSTIFKDCPHVEVIDGVDWTEKMQERLLKVIPNLRALHLRAGDKINAFQGLKQISHISISFKMEMGNRSKDITRNIDALEESSRSLLDQAKVVLENSSVEQGKFVRLIYMVPDPDKGTYYRPAWKAVRMKRIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNW0</accession>
    <name>A0A2R6NNW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001067">
        <property type="protein sequence ID" value="PSR73727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNW0"/>
    <dbReference type="STRING" id="98765.A0A2R6NNW0"/>
    <dbReference type="OrthoDB" id="2745559at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14059" checksum="2FD0101E5FF861BA" modified="2018-06-20" version="1" fragment="single">LRTGHAPLRKHLHKIGRADTPTCQACGEAPETVPHYILYCPAFNHPRAAMSFELGDDARSLTSLFTNAGSLRSLFRYIHRTRRFEEQFGGMSLPPAKEIREKAKKRGLKDTGKEKQKKRNEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP77</accession>
    <name>A0A2R6NP77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001013">
        <property type="protein sequence ID" value="PSR74202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP77"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="400" mass="44205" checksum="026B5C39DB42D4C0" modified="2018-06-20" version="1">MPTERKTRQHTLQDSISDFLATVPVPFIGDMRHGMWVLELADLLVEYIKLDPSLEWNVSREVMKLMQAMMEPYANKSWVDTVYATLPMLANFHEDGPAPGGEQLSDTIYVKKSDQVSYAFWPKLFGLTTLQCALCRLIKRRKECIFPHGASKCTICAKRGRRCHGYKGDTEDGESTRTNKRKTSAATSVEGSSRSSTIPCTDGLPDTTVGDLRAEKRMRYADEGGQGGRDVTPQPVAKDGSMDSSELRITRLTPLHGASPMVQAITSHPSAVMTTLATSSATTYITSSVCVNPAVRDTASTQPGTARLLIPETIPIRRQSTRLQCAMAATEANDASRLDGLDGIGLPVEVIDEIREARNLMDDMGSRIDAMQYIIRCLDARQRQLFDTHAPGSQMRNWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPV4</accession>
    <name>A0A2R6NPV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPV4"/>
    <dbReference type="STRING" id="98765.A0A2R6NPV4"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="21747" checksum="F4C30E62E0598DD4" modified="2018-06-20" version="1">MSNTIALTKEAQPEEDPSVSARLQRLQNNYEDFGMRRTVEGVLVVHDHGHPHILMLQIANAFFKLPGDYLKPGEDEVDGLKRRLDERLAPPTDSRQFNSSHGVDNDWEIGDCLAQWWRPNFETFMYPFIPAHITKPKECKKLFLVQMPERKVLAVPKNMKLLAIPLFELYDNAARYGPQLSAIPHLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ21</accession>
    <name>A0A2R6NQ21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ21"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ21"/>
    <dbReference type="OrthoDB" id="3261813at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="754"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1047" mass="117131" checksum="2097E1EE20D0139A" modified="2018-06-20" version="1">MHDDHFHILDNTSTNPENDAVPELTVDALEVIELAVIVIPLHKEPLIVESAIDSLQKSVTLMRRCSQQKPLIFFITQLARLFFSRFQDVQEIRDLNQSIIHLREGTNLFAADNVALASCYGHLVHELSLKFELFQNRSDLEDAILSHETMGKLPQRSTKHVDGAMIASSRRIAASDDWRTTHTNLLFLRFMDTGQLQDLQSAIEMAEDVLQGCPDGKPPLREEVSTCLVNCLMQRFRVHGRVEDLRRIEELVLHDSARSIDNVHILGKLLITAFDWFRHQEFIDEAVKYSHLSVIAMSSTLKTRIPTPQDGIPEAEELEELTFAQAALQQLYNAEFAARYTQQSWWQEVLSPGSRMRPVNSWVEETSRLHDLGCAITKQFAVSPLRDNRQMSIALTVLRLAEQLAPRNSSQRWEYLFSLGTSHRVRHEIVQQPGWKDIKRAVELQSKAVEKLLVPNPRRIPALSSLACSLLQLAQASGDETQYYRAVELLEHVADAFYGFIHDRLEGAILWASLLHSDTPFSFEDEQTQLQRALEGYKKAISLLARAVWIGLSTSSRLARLHSVPKTFASDAAACAIRLAELQSDPQRRQQYLGTAVELLDQGRAILWSQASQLHADLRLLSTRQPELAAELNGVAAELARTAFKDGNADSGNATADLAYKWDELVDRVRQLDGFHDFLRSTPFAALRQAAGPTTIIIVNVSEHRCDTIIIPSQGAVHLVPLPKLSKSQVDDNVQDIHSLLPSKDDRGEFETIAHDLWGDICQPVLAELREMGIVDQSPRSSGAAPHIRWCLTGRLAFLPIHAAGPRYQSRRKPGMLDWVTSSYISTLFMLLRAQQRREALQGQVPVPRVLAVCHSGGDERGRLPKAKEEVEILCSCLKPGAASVIMDNEARVDAVSDALKKSNWVHFACHGTQNKTNPMDSALVLDDGRLPVSKLAEQNLKGEFAMLLACETAMGMPGLSDEAIHVAAGLHFAGFNSVVATMWSICDEHGPIVAGKVYKYLFRKKEDGSPADALEAAQALRKALLFLRDKQKLSVRDWAPFMHFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR50</accession>
    <name>A0A2R6NR50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000925">
        <property type="protein sequence ID" value="PSR75126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR50"/>
    <dbReference type="STRING" id="98765.A0A2R6NR50"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="233" mass="25644" checksum="153CF3DDBC81D83D" modified="2018-06-20" version="1">MLMVWDLSPSLNIPSHNSPASPSSDKAFTSRPQPTAYVITFPHPLSSVCGHPSTSKEFLVADTRGSIFLTDWRSDPEQHSWRNSSVIELVEPRALADAVCGLQTRWSGSVAWRRDSVDIIGAAYGSKFALWDLSKLQGGKPAITGSTFPEGGTKFRWSPTYSEYFAVTTNCPAKGAVIHVYNASYIQAQPTVFNIAPRPLYVRDFDFIAERGIPRIVAAVGREIITFYIGVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS13</accession>
    <name>A0A2R6NS13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS13"/>
    <dbReference type="STRING" id="98765.A0A2R6NS13"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="238" mass="26640" checksum="B2FC7D887EC612C2" modified="2018-06-20" version="1">MIADFGLSRVMEEEKMQLLTEICGTPGYMAPEIFKKTGHGKPVDVWAMGVITYFLLCGYTPFDRDTQQQEMEAIIAGDYKFEPEEYWANVSETAKDFVRECLTIDPTSRPTAEEALNHKWLADAEPHFVQDQQGNMTNLLPQIQKAFDAKKTFRKAVFSMMAMKRMSTLVSAKHLSPEAQALGVDVARYKEESEKDHDVLHYPSGDSDNAGTPPVSPHGRPAPLESAMAQMSVDTNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS80</accession>
    <name>A0A2R6NS80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v9016</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS80"/>
    <dbReference type="STRING" id="98765.A0A2R6NS80"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR75725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="16224" checksum="D8871A5E39DF8371" modified="2018-06-20" version="1">MPALELKTNVKAEDPRALVAELSQLCADVFKFPIHLICVSYEYNEYLAWAGTFEPALWINVSTLENLGVEENDRYSKALFAFVGEKLGIEDSRGFIMFNDPGRENIGYVPRAPFLSILQNSQLADHDGSGCSYRSTTVRMVKGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSA4</accession>
    <name>A0A2R6NSA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSA4"/>
    <dbReference type="STRING" id="98765.A0A2R6NSA4"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="100"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="493"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="671" mass="75242" checksum="51225CCA5E13A8F8" modified="2018-06-20" version="1">MKAPTKITKAAPIHIPSNKDIPRPVRPTEPEYEVFDMRVDNTPEYRMTTTDAEKALKDLMTDVKDGGDIEINMEDAIVAGFKDNVRLLPHQVIGRTWMKERETGKRTGGILADDMGLGKTVQTLVRIVDGRPTKSAKAEGYAAATLVVCPVAVVGQWASEIRKYAEGLTVIEHHGPNRATDPEKLKKAHVVITSYSIVANEHATYAFDATDESKPKKSKKSAAAASDDNSDDSESNFARALKKKSPVKQKDALFKVKWWRIVLDEAHNIKNKTTKSAIGCYALDGKYRWCLTGTPMQNSVDELYSLIKFLRIKPLNDWTTFREQIAQPVKAGRPQRAIKRLHATILNGKPLLNLPDRIVNTVQCQFDPEERAFYNNIQTLVETSLEKLRRQGDVSKSYTTCNHPSLVSQDYRKDKEAVEPKAAKNDDDVDDNADELADLFGGLGLAKSEKRCQICQTPEDTSCSACEGMLSKAKDKSSVAESNLPPTSAKIRMILKLLQDIEDRGEGEKTIIFSQFTSMLDIVEPFLKSRHIKYVRYDGSMSKQHREEALEKIKDSKTIRVILISFKAGSTGLNLTCCNNVILVDLWWNPALEDQAFDRAHRLGQTRTVNIHKLSIPDTVEERILELQEKKRALATAALAGDKLKNMKLGLDDLMDLFKHNADDRDDDDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSR5</accession>
    <name>A0A2R6NSR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000868">
        <property type="protein sequence ID" value="PSR75998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSR5"/>
    <dbReference type="STRING" id="98765.A0A2R6NSR5"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR75998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1073" mass="117833" checksum="46286310DEED5E0F" modified="2018-06-20" version="1">MDPNFIQTLHNLLVQSTANDTVQLKAATAQLNREYYKNPACIPALASIIASSPETAVRQLAAVELRKRVSQNDGDMWTQVPLSERNQIKSKLLELILAEPSNLVRHSTARVIAAVASVEVPLGQWNELLPFMEQTCRSPSVSHREVGIYILYTVLENIVEGFESYMQNLFKLFEALLADPESAEVRITTVRALGVIAQYIDSVDKDEIKSFQHLLPSMINVIGQCVESGNESGARQLFDVFETLLILEIPLLGQHIPQLAQFLLSCGANRNYEEDLRILALNALNWTIQYKKSKVQAHNLAPAILEGLMPITTEEEPEDIDDDAPCRSALRIIDGLATNLPPSQVFPPLSQLIRQYFSSTDAGSRRGAMLALGVAVEGCSEYMTPLMDQIWPIIEVGLRDPDAGVRKASCVAISCLCEWLEDECVGKHSLLVPTLMQLVNDPPTQRTACSALDALLEVLGDVIEQYLQLIMEHLAGLLESAPLPVKSVIIGAIGSAAHASKDKFLTYFQPTMLHFQQFLVLTGEGEEQELRGITMDAIGTFAEAVGKDVFRPYFSDMMKQAFAGIQMNSARLRECSFLFFAVMARLYKEEFAPYLPEVIPALMSSLKQAEHGEELSLSNGEAAASFASGSSPATAISIEDSEEIVDIDKLLDVNSTICIEKEIAADTIGGLFANTGAHFLPYVEESTVELVAQLSHYYDGIRKSASDSLLDIVRTLYEQSNPPEWQPGQAVQYPLGPPVKELINHVLPALLDMYETEDNKKVVASLCIALAETINKVGPAFLEGKVEQIANIAIQLLEGKAMCQQDPDQDEEEEAPEDTAEYDSILVSSAGDLVASLANALGSDFAQAFPTFFNLISKYYKKNRSLSDRSSAIGALSEIIAGAKEAVTPLTEPLLELFYRALSDSEPEVLTNATFASGLLVEHSTMDLSSQFLHLLAAYRPLFDVPADAPIARLNARDNAVGAVSRMIFKNPSAIPLDQVLPVLIGAMPLKQDYLENRPLFRTIFHLFSTQPLVLQPYMDKLLHVFAYVLDPSLPEQVGEDIRKELIALITLLNREDPVKVQAAGLAPFVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSS1</accession>
    <name>A0A2R6NSS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSS1"/>
    <dbReference type="STRING" id="98765.A0A2R6NSS1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="620"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="90342" checksum="05BB11596FCCF6DC" modified="2018-06-20" version="1">MLQTRTGFQSQPSSTSTKGSQGPEHVKQSRTQHLSLRKPKVKVNPLRFLPQPDPPLVEMVDKLFLQRRAGESTVETLRTSVEPSLLAHLQDSEKARALAALMVNTSVPQRAHRVLLLAHDLGCKFKQNAYEGVAYQLAQTGQWAEMPSLVALGKRQTGRTNARLLNWRARALVEISHFGLLEDVLEDFQEEHIQPNRRTFHVLVSGHIRNRNLAKAKACLEWMEQAGFPMDASTHALIVSNYRSLGADKPVQTRAFESLRELGERTATIVVNSLIQLALDTHDMEGALRYLSYFESSVSSQHDVDSGDVTTPQDGESQENVDQSNTRGTLVPDTATFTMLINYLAKKQDLGHALQILDRMKLLGVVPDSRVAAAVIRAHCAAGDLSTSVYIASTMCEDLPSTRPLFIWLGLEVEDKHRPDLIPATVPMTIEVINALLKGVLVRRGLNGMRVMYDLMRATGLRPNDETVSLFLSHLAVAERMRPRELIRILKRISVDVRPTLEHLHIIFRSLFRGESESVRRRGWQALRARAERKDVQISVPPEKLSTESKLYDPTAGIEVSRLTYGSLIRPLVASLTARRVRVDRATMNLRIRHDSTVKRSMDLARESFQTMLDRGMHANEHHFAALMEGYTLSGDMHTAEEIFKSAMQAGMRPNVVLYTILIHGYAQQGKAGLAMRTFEQMVASGVQPDVGSVDALAGAWFAVGASGISRRVLLQLWPHIAPLPPELAESDLKTLLQTFRQLGSGPLKLRTKQTRQQYRMLRWKLKRIMVHWVREKRVRRQRRHENPEGPVADTSPNPTPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT11</accession>
    <name>A0A2R6NT11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Solute carrier family 35 member F1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT11"/>
    <dbReference type="STRING" id="98765.A0A2R6NT11"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR76137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26723" checksum="B0B89955695323D2" modified="2018-06-20" version="1">MPPLLLGVHAPEVPLEPDLRMYFPRPVYDPLGCSPQYVLCVQGIVVCVGGLGMLVASDEMTDKDWPALSRAKGDVFMLVGATLYGFTNATEEFFVRRSPLYEVVGQLGMWGTLINGIQAAALEHEGMKTATWDGATIGLLVAYTGAMFILYTVAPILYRMSSSAYYNISLLTSDFYGLLFGLFLFHYRVYWLYFVAFAVVIGGLIIYFWSATPESQGKLEPRAPEYVHRRRDSDRAVGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTR1</accession>
    <name>A0A2R6NTR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTR1"/>
    <dbReference type="STRING" id="98765.A0A2R6NTR1"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR76510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="363" mass="39637" checksum="62573CFCCE39F5FA" modified="2018-06-20" version="1">MSEYWVSHKKYFCKYCNIYIADDAPSRNHHEGGMRHKGNVERFVRGLYKSGEKRKQDLEEEKREMAHIEKAAQAAFAQDVGAGLVKPGSSSTTAPPKEAGPSKPVRKTDLYSDYSTAASLGYTDLDAERLNAEAERRRKEGVAGDWELIAVEEPSTATEVENIRGHAAVPIPVQREADLKREAETQLDEEDTRAFKLRKKKLGAGMGEIYDPGIVPIKLKVKKEEAADELTTAAAKGSQNFNNAFAPGNSAATSVPKWSARGWSKPGTQTEDRPDDQSHEEQSVEGGKEPASQEGGLAKEESYNGVPLSDARTKTESPSTSVKLEEVAKSEELEPAAPAPSRGGLFRKRKLPVGGAGSRGRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU97</accession>
    <name>A0A2R6NU97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000836">
        <property type="protein sequence ID" value="PSR76752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU97"/>
    <dbReference type="STRING" id="98765.A0A2R6NU97"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="71859" checksum="7164C4C5FFDF9B64" modified="2018-06-20" version="1">MDIVKAIETYITKMVSVPNAMKVLLLDTHTVRSTFLNIPISLTRFLCVKTPIVSLASTQSILLSHQVYLTDRIDNQKRERMAHMKRAAESSTYNTAHVHACHGDITDFSNILSKAAIERLADVDEYEVVREVQEYFADYAPILPSLFSLNHIPTAARPFYGSSPNSWDAQALDQSVQGIIAVLLSLKKKPVIRYEKSSPMAKKLGVEVQHRIQQESSLFDFRGTQVPPLLLILDRRNDPVTPLLSQWTYQAMVHELLGIQNGRVDLSLVPDIRPELKEVTLTPSTDPFFLAHHLATFGDLGTSLKSYVQSYQSRSLAQGPSSINSITDMKRFVEEYPEFRRLGGNVSKHVALVGELSRVVDRDRLLEIGEVEQGLATGSGADLKSVQTLITNTAVPAWSKLRLVMLYALRYQKTQASSVASLINLALENGVQREDARLVYVILNIAGSDQRQDDLFSAESLLAKGRSALKGLKGVENVYMQHTPHLSQTLENLLRGRLRDTSFPFIDGAGVNAGLQRPQDVIIFMVGGTTYEEARTIALLNQELASGGSYAAGTRMLLGGTCIHNSSTYVEMIRSATTNWPSSVFEPPPESATNMPSLNLNLGGVNVSLGGRTGTGVYRTSGEGVSMQTDGIRDGVKNLFGKVKQGVDRIASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUP6</accession>
    <name>A0A2R6NUP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUP6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="258" mass="28861" checksum="CE80705352C7E1F2" modified="2018-06-20" version="1">MALVTLIDTPRHPQSHEEGMSHPVNYYALSKVSNMKRVPIVGAEQILCKIPAVRICLYRQPPNKGALHKTTGAILKHIKEKDARLVDAILRISSLASVLSPPPTWDTIEDTTWIFDAVKTPRFVSVDTIARAFLAPKTSEPTDPEDLLMTPSPSYYMATPRPQQHPTRVYSMCSLAFLLDDQQRWTCGICAICSIDVVALGVLPASYRSAPGVSRISGKRLRRRKRPWLKLHTLKPPVGLNRSRTMTEAPPLCQQTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVG0</accession>
    <name>A0A2R6NVG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v8016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000809">
        <property type="protein sequence ID" value="PSR77187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVG0"/>
    <dbReference type="STRING" id="98765.A0A2R6NVG0"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="486"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR77187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="572" mass="61703" checksum="55E4866E6BD3A368" modified="2018-06-20" version="1">MSLKAELETWAAALKAYDEEDYEKSLELFSAIGDSSKILTNMGLIYATLGEHEAAVEQFIAATQLDQFLAVAYFQCGVSNFLLQRYDLAFRDFDGALLYLRGNQNINYEQLGLKFKLYSAEVLFNKGLSQIYMGDVEAGLADMQEARKEKATDEHNVIDDAIADRGDGYTVFSIPVGVLYRPSENKLKNAKTKDYLGKAKLVATSDASDAYTTFTGVTRFKQGISPSGVMLDDAPVSNLNRAATVAVTSRPSVPDEDRPQASLQRAKTTINVPSDARDRIRALNTGSAPGSSPSSPVRDGGNNAAIADAALAGASAGLARSATSGSRNMPPGPMRGLSVRRPGGPAPPSLGIQGGGAAAAAGMSSSRSSPTSSGRKPEARLTEFYDDYLDSYGATEEVPPLPTTQRSPDRVANWARNNANPATSAGVQRSRSMAPPSSYAPSSAGGTLRRKTTRRTARTARSTYYEDEDEGYASLDYEEGPFEMTKIRVKIHYQDDTRGMALDAALPFDDFVDRVTAKFGKSFNGLGLKFKDEDGGKVSLRDDMDYELAIETARESAKGKPEGRLEIWCVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVG4</accession>
    <name>A0A2R6NVG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVG4"/>
    <dbReference type="STRING" id="98765.A0A2R6NVG4"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11430" checksum="0DB20E59FEE4FEF9" modified="2018-06-20" version="1">MAAAAFVKHGKKASRNYADHIKELNNAVPKEPFFFLKPTTSYLLTGEKVEIPRGITAHHEGSRSSRYPQQFMALGIDSESQLNSALSLVNGDEISPRQMRTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVP5</accession>
    <name>A0A2R6NVP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVP5"/>
    <dbReference type="STRING" id="98765.A0A2R6NVP5"/>
    <dbReference type="OrthoDB" id="3235609at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="35929" checksum="E5565B6D413156E4" modified="2018-06-20" version="1">MSSSRHSHIYYRVGGFQSNFKLKSINPPIPYTAKEIAEALLVQKAGIDLILGVQPCGASYLLLPREDAEAAFHHLFKGYGTPATEYLSLSPIHFEDATAFAAKLTKLANKTTAQKKKKDQDRSHANTQYVLGADPFELTLSGISRANFEYHRLFLRILRDEIERPYDYDIVIPTWLQNTRAVSLAYNLWELDHRPQELRRTDPKVLDIGWTEYALPNPTNPGPIATSTVQAKLSENRLLRAPNYQISQDGIGVSSPSLGVGYSGSLARLPTVILTAESQTSLGIHTLGNGQAARSHLDEGTTLVEHDLLKSHKDHRRSTWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVQ2</accession>
    <name>A0A2R6NVQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000785">
        <property type="protein sequence ID" value="PSR77676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NVQ2"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="848" mass="90597" checksum="1AB0A0A14FCEC996" modified="2018-06-20" version="1">MSVSPQPLPQSAILTRSPPEISIGTPIASLSHATSNAGDSPAQLASLLSNSLMEVDSLKRELASMKRRAEKAERLVTSFQKLSAAVGSPNHSASGNSTPANGQLDEQSARLLIMECEARAEHYLIERDELTARINCMQEGWEELDRFLFQQTADASDARARFSLLMNKRGGDLVVLSRDGPPHATALVNTHQQLAARDSRPRPSPRLSVRTSVPTSRSGVPLSAQQYSSIPQPPPPTQSSRVRPRAGSLEGSPYAPLTGPGGPPPSKRMRSDRDYDRDLQVPQGHSYSQSPGNSPRLVYQTNGQVDRSPPLSVPPSQGPYTHGQPQHSYRHRGRDDGVQIRYTDASGQSSRHPAPRGRRGHRSVSRSRSRSHSRASSASLDEMLLEATTGDDPDRRVDSNGVPILQQQPRHPHGAPLSAHPSQHLSPNAHVPPRRQRSMSNERDREYLAIPYHNSRSRGSSQSHPSLHPSSSMSNVVISAGGIPSGPGVPGNAPPLTQVQTYQTHIFAPPVTGAPVKKTPTTGVITGISGIGGGGFPATNAQGQRICRQCGLPGRYKDGKCVEKWGPGPEGPGTVCDRCRKKMKRVERRGTLDSQHLANNSHSGPAAVHPSAAALQHPPTNGRSSQQMLISQGSDRSLQRTDTLPAGHIVSRAGLGSSSTLILANNSYARMEREEPRTRPASPQVPPQRAAARRSPPTPPYIDTLPNTGNEGDDSSNEVERVVSRARTSRVQSPEPIIPRPQSNGHHVRSPERISPPSQPAASGGGSPQRGSPRGSEVPAGNTGKSKPPPIEADADADADADAEADLDADADIDAEADADADAELLEAVDAAEANNASGEEWLKKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVS0</accession>
    <name>A0A2R6NVS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000779">
        <property type="protein sequence ID" value="PSR77739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVS0"/>
    <dbReference type="STRING" id="98765.A0A2R6NVS0"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="285" mass="30416" checksum="4F40B0A44125C701" modified="2018-06-20" version="1">MFSSNPHRSSSSVRLSIFTPLPTQEGTSSPSSSSLSDESPVRTQPPTPTRPRSRTTALTTTTPRHRAARTRPRASSAGMSFSSNLAFSPASSSSRPGTTTVIGTADPGSPPPYSPEPPELDATSPFLAKRAASSPHLHSPPLSRSSLHVYPRSQANSRRPSTSALHPLAHPTRHRPTYTRPDTDDDEDGGRASDPQSGDETMVRRSSERGQPGTLRERLFGMGRVDAASVRLVTTAPGVSGAGETETEGEDLVSLMYAMFSSALALAAVPIWEKIRSKYAVELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVZ6</accession>
    <name>A0A2R6NVZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000767">
        <property type="protein sequence ID" value="PSR77947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVZ6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="13877" checksum="9D87348FFF80F7A3" modified="2018-06-20" version="1">MRRLSSANSGQLQPLSAVVERIRYKAYKTVSGQHGDAYVFPGGIHHNARDYTEPSTHESLAQAEVWVLMLPPCSHPGFYQFYLTQFTAPHTWRQDCDSILFPEKRCQNLGRQLVPCGMLHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWD0</accession>
    <name>A0A2R6NWD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWD0"/>
    <dbReference type="STRING" id="98765.A0A2R6NWD0"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR78205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="182" mass="19464" checksum="654BBF42D9B38E4D" modified="2018-06-20" version="1">MVFFTELATNATKNGVHIITYVGNDDGISPHFGTEVTIQNTTFGGIQGFTRRPSTPWFDDNGNWAGIVHQERNWTYALIYGAGHEVPTAQPVAAYTFFREFVLGDNPTGRIKSDGDVVAVIGGENPTLNQTAIPGQLGIVFGSKSAQGLYTFPSATIAAWESFVSFVPITGTDALQPTSTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWG9</accession>
    <name>A0A2R6NWG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWG9"/>
    <dbReference type="STRING" id="98765.A0A2R6NWG9"/>
    <dbReference type="OrthoDB" id="2020852at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="230" mass="24860" checksum="C4E3ADF6694D3EC9" modified="2018-06-20" version="1">MAHMLETPSRVWRRIEDIDGQEMPSLPSIPVYEDSAEHASDITDSMSLDNDSLNPITSTPAAFSSHTNTMTTIRPPPSAGSTARFAQSIASRSSKSGLGTSGSRLGSSGSTGRPSMFQRKEQSFDISGIPSLPNMNLRDGLDDVEIRSSDQETTEGRDNSMPDAYLPPIDADTGAEEEFDLSDALQSISRSNSPSPKNISIEPTPKKKYDYSISLRSEPQVTSSSNLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX03</accession>
    <name>A0A2R6NX03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000751">
        <property type="protein sequence ID" value="PSR78272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX03"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="8664" checksum="63E2A7A582E2435E" modified="2018-06-20" version="1">MTERDDAQLLEAEDSLATLHISKPTTTDEPPEPNSWQDFTHNILEVSILANNTLEGMAKWSDVSALDPSTAKGLAAELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXC0</accession>
    <name>A0A2R6NXC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXC0"/>
    <dbReference type="STRING" id="98765.A0A2R6NXC0"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="628" mass="67563" checksum="407A49DF92865E1B" modified="2018-06-20" version="1">MCDYFDPELELLFNDAEEDDGGAQHAMRTAPVFTGDAFISLGPDIMPQRALYGRIVSQHVPGFPTIPSSPKFYINTNAPFSALVCGVQGSGKSHSTSVLLESCLMSHERLGTLPEPLSAIVFHFVTAAGGGRVQPCEAAYLAALDTDRGGDATPPAVTVLVFPSNLQSMRKVYAGLPRVKVEPLHLAPEDISGERLLSMMKVDENTQMPLYMESIMALLRSMDDNFDYGQFRSELNKQKFSGSQKAMLKLRLSLLDSCLMGGNLLNRVSNHFRRGQLTIIDLSSPYMDGSSACGFFDLILGLFVEADVNASGKLVVAHRFSSPKWMRLLGQHISAADSTIGELFTKVVSLRTGEAIVFAPNGLGMQEGVDTDDPCPRSVAPIGEGYLVVRSRQRITRDGGQSLLAVQDVNITTRLGRVARDSVSSESIPPVDEPQTPPGFVQQNGNLGLSGFPTEVGSPDTWNFGWAPRTAENSADWGAPPGSSKTQWRSEPTIVPPFSASAYNGGPTSSHYTLPSTAITDSTPLAPADPPPAAYSKVIRMDAPRARFAQLIKYLQGIPDDNCKMRLIRKYFRTQEPLAYGTLSADINSAITQAIALGVVSATATATAFPNSKPGSLALVAGACYVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXL0</accession>
    <name>A0A2R6NXL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000696">
        <property type="protein sequence ID" value="PSR79397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXL0"/>
    <dbReference type="STRING" id="98765.A0A2R6NXL0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="47"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="860" mass="94488" checksum="9C0EFB33318083E0" modified="2018-06-20" version="1">MPTTVPSGSSTHKPTVAEEGYNELEKALRKVLLDIANSKSRSNTQGWPEMAKTLRDVDEEKIKDTKEDIDTLLVFAGLFAAVLTPFLAETYQTLSEDPGDTSVAIQRHMSAQMSSYVFIDGSLNSTVPAYSADDPSFILPPFALSINVLWFASLTLAVVTASFGILVKQWLREYMAIETSRSAKARLRVRQFCVTALDDWKVFDIAAILPLLLQFSLGLFFVGLCFFSWSVHPTIGWTITSIVSGWGVCFFFAIIAPAFSARCPYKTTLLKNTIRVLRGWICSSRITGRVYFGPVTKTGAPIEDGDAATNAKGDVQILTAADAILLDDDLLVTTMSDSLGEIQSSLNSVEVIDFVVAALQQRSPGSSPITRQIVSLDLRRLLKRTWTTLVTISARILKRNRLLRSQSANDLDEWEKDAIMILSTFYPSTLISEAGDALTLCMTAALIPTCQLIGSAQNLLIGHKSLDSDRSKNLRPHRWLLHILELLRGQLSLIAIPDLCNNACDHDSSRLDLGELLSAHADRLQKSVISVIGQILIDHRNRFPASARESDPLYGDYESLTIAAGGALKNDDFLHDALPVALNHNNATPADSMKLILGVIRNRQKQDIPLYGATCLLELKEISEDAWTTIMDATARLLNDALESPQCSYASCTDWEVCLKDAVLVLLSISEYSMTEEGCRILVRCTSSPEDRQSIIHQLLSLSSGPQITLYENHQGVFKRLHSASSPLMLFRMEETTSGAVDFIQSSVCNGACVHGKGFREMYMAHQDQVPVFSRVAHFLMASATAAKSSLGETSLSGLYDLLYAISPTSVSTEATRQWTYIAISASACAMADIHVLDSTYHHLGGRGKNIVLFAVQCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXP3</accession>
    <name>A0A2R6NXP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXP3"/>
    <dbReference type="STRING" id="98765.A0A2R6NXP3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR79472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="682" mass="76297" checksum="C2AFDB6FF49E387E" modified="2018-06-20" version="1">MADGASAIIGIVAFGLQAVHKVYEIIDSIKDAPTDILALKHDAEQIGSLLLQLQQLRVTDSAVVPSGVNAAILMKLFEDALGEVESFVNKVAESRRDGKIRVKKLQWFLRGGRCEKLRGSLTSLKTSIIAIVAASTSQSVDAIQPFIIQLVEAFKRDHDSWVTRQAAEFANLQAAMEERMAAFAHNQDRIYCILASSSEVIQPPSASCAPPAASESMSVPDIPRSVEVQSGGQTSQDISFSPRTSRPLSVKDLKLPLQCESRCECCCHDTRLTRATPYWCSSWFGNLYLPRSFFHWSFASCNVQTCRRTQKNRQIAKIKFFFPSWFIAVDMKIRLEAFPVHFCLQTPRRVRDTSPIFQCIMRMDIEGVRKLLVSGEASVNDVDGYGWGVLHWAARRIHYYSYEQTSEMLQLLTDEGAHIEWEEDMWHRTPLQLLQQSSPPQQYQESHIGLAHPLQIHIAGPIFHEDIIDSWEDWLERCDFPDVHRAVLTHRTRNMSLRDMLLGTAADINAPCQMGVTPLEWCIWMGIPNVLETLLQCGADVYEGCPLHLAASSGDVEALKLLVHAGADINLQHIDGSTPLHMAAYYGKAEYVKELIRIGGDDLDLGALDHCYGNTALDIARAGRIKCEEMGWPTDDRDKIILALLELQASSGGRRMPEHSDVTNAYIEMVEDLCMPGSFPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY11</accession>
    <name>A0A2R6NY11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY11"/>
    <dbReference type="STRING" id="98765.A0A2R6NY11"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 72B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045:SF37">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 92A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="394" mass="42668" checksum="00CF69F02ABADCE2" modified="2018-06-20" version="1">MLHSVRKLSKKSVKVICWVSCSAAAGYSLFGPAGCAKGSGGLRIRLEEQAERTGKPLSEVAEELFCSVKGDVIRVPGMPPMYDYELSPQEMFIKGPMFGLFSLAAVELVNGCDGILVATPDCFESTESLAALRTWFAETSREVYTVGPMLPPSGKNATVNEKKQSANPEEIDEFMGQTLKTHGKQSLVYISFGSVFWPVQAEKLWAFLDVLLEKDVPFIMSHGSPFAQIPDAVTEKVKASGLGLFSPWSPQQTILAHPVTGWFVTHCGFNSIMESLSFGIPMICWPYQADQPQNAIHLTDNLGVAYELLEVRTGELGSKPIYRTGKACTGAIEALRNEVQDILGKAFGEDGAKKRAKAVELQGAFEAVWAEGGSSRLALNKCLDALTAPETGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYT9</accession>
    <name>A0A2R6NYT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYT9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="7959" checksum="BCC83F77786B3D72" modified="2018-06-20" version="1">MSSPLILSSFAEEPETAATPVSQPSNSPSRHYRTLSEKKAAALAKTRTSKRKADDQGPRLSSKLPVTAESVTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZH6</accession>
    <name>A0A2R6NZH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="20">3.1.-.-</ecNumber>
            <ecNumber evidence="20">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PHLCEN_2v6406</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="20"/>
    <dbReference type="EC" id="3.6.4.12" evidence="20"/>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZH6"/>
    <dbReference type="STRING" id="98765.A0A2R6NZH6"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 20" id="KW-0408">Iron</keyword>
    <keyword evidence="14 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18 20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 20" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="22">
        <location>
            <begin position="36"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="23">
        <location>
            <begin position="614"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="23">
        <location>
            <begin position="724"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="24">
        <location>
            <begin position="792"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1059"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1081"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PSR81327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1122" mass="125176" checksum="FE9D763729AA55F7" modified="2018-06-20" version="1">MTCIATMYLFQCEGRDTAEQTKLLNVNDESSYFCDVVNAIGRFEVPPSSSSATPLPTIEVTSKANLVVHHPDILITATSLSNAPQCRRKPLLQNFVRSTSEATPALVWGNILHEVMQTCLSEQCWDDRFIDARIAEVSQRCLGELLKIGVNLDQAKREVKARASGLQTFAQRYISQAPKEAAVLVNTRSERGQKSLLAISQLIDVEEDIWSPTYGLKGKLDASVQAVITDMDESSNPFAKARPTATTTSVKVPLEIKTGRAVAGMEHRAQTMLYTLLMAERYETEVPSGLLYYTQSEEVVRVPAARNEIKALIMARNEMAIYMMRRANTGGTSGKTGDAVPDVEASVEPEPFLPPTIDDVRTCGKCYVVDTCMLYRRAVENVVDDSSPISDIYDLKTSHLTPTQGEFFKKWEALISLEEQDLVRFKKELWTMGAAEREEKGRCFSNMVLDTSQSPAVKLPPTPTPTLKQEAKIHQFTYAFRKASSSAGQGSLLNGHMGIGDAVTVSVEPDLIAFVRGYILNLTPEEVVLGVDHALSIHDIRKRRPRVGPVVFRIDRDELFGGMGRIRGNLAQLFYADGDTRRLELVVDLRSPVFDPLEGPIVPEHEPLSKVVAKLNNNQQEAMRRVLGARDYALILGMPGTGKTTVVSAIIKALVCMGKSVLLTSYTHSAVDTILLKLKDDADFGILRLGNVDKVHPDIHQYTLSARRTATNIEQLEYQVMTPPVVATTCLSIDHPLFSRRKFDYCIVDEASQITLPTCLGPLRYADKFVLVGDHFQLPPLVRSRDARKGGLDVSLFRRLSEAHPHAVVDLVDQYRMNEDIMLLSNKLIYSNRLRCGSSEVAKQGLVIPERSFIQNLHSSSDRPKCDCWIEKLLDERFESPLLWLLYVLAQGLSFFSSCNAVFVDTDSVPALDSRVGDLVQNVTEARLVHQILESLVRSGIAEDRIGIISLYRQQLKLLSHLLQDYNGVEMLTADRSQGRDKDCIIISMVRSNETGQIGDLLKDWRRINVSFTRARSKLIIFGSRKTLQSAPLMEEFFSLMDERGWILKLPPGADKLHASLVGSPRKRPLDEASHTSSMDSKLEESESPRLQKKARKSVLTEEGLLRGRAILKDLVNERHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZM3</accession>
    <name>A0A2R6NZM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000635">
        <property type="protein sequence ID" value="PSR80889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZM3"/>
    <dbReference type="STRING" id="98765.A0A2R6NZM3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR80889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="22308" checksum="38EA020F78248F49" modified="2018-06-20" version="1" fragment="single">GKVYYDGLATDSVNLDALRSQITIIPQVVGSSYPERDNPEGLTSMSQPELLAGTIRENIDPFGQYEDAILNDALRAAGLSSLQSKTNEGRLTLDSAISSGGGNISVGQRQVIALARAIVRQSKLLILDEDYETDSVAQESLRKEVAKDITLLTIAHRLRTIMDSDVIVEFGKPSKLLENAQGFLCSLVDASGDKERLHAMAADNSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P025</accession>
    <name>A0A2R6P025_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TATA-box-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000604">
        <property type="protein sequence ID" value="PSR81929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P025"/>
    <dbReference type="STRING" id="98765.A0A2R6P025"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR81929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="27992" checksum="C18A08E696421E28" modified="2018-06-20" version="1" fragment="single">VTFGRSTHVPAQQQYQQSQPQPYSQQPQQANGLALPYASNPYLPGPSSLALPGPTPSALSYPSQPQPTQVQTQPQTQSQSPTLVGSSQSLAGPSTPGPSAVPATPAPLTLEQQHITAVEGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVVTGAKSEDDSRLASRKYARIIQKLGFDAKFSEFKIQNIVGSCDVKFPIRLEGLAYSHGQFSSYEPEVLIGNNMIILKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P043</accession>
    <name>A0A2R6P043_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000602">
        <property type="protein sequence ID" value="PSR81964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P043"/>
    <dbReference type="OrthoDB" id="2986975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="276" mass="30539" checksum="052D4A151734D36E" modified="2018-06-20" version="1">MAGYNPLVVTRTNPLCKATNFETAPWDNAFLVTPQHTVGKLWNDAANRKHCTESGNQLFICPAEDSIKKKPLTMRERFCVAGHHTSEDGTKKRQRDGLPDVVGLAIGMKVMVTSNVQTDLDITNGARGAIQDIILHPDEPPVPPNTPIVKLTYLPSYVLVKLNCMQATQLQGLETSVVPIEAPLQTFHIATTYHQRRKSYLLEQSISSNTPFQRCTASPTIAPRVKHYPMCLWILPLLRKALLNGDLGSKSISSVHRLLSPPSGSTVIGWNNEQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0S7</accession>
    <name>A0A2R6P0S7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000577">
        <property type="protein sequence ID" value="PSR82740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0S7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="12528" checksum="15DAEA0078E04E21" modified="2018-06-20" version="1">MATHTRTVHRKMYTELRLLKAGWVTLVVNPCLSAWKSKIITRLVLFYGDGWGGFIATSTINPANWTPSLLLGLHPSSTSPPMQLSPEFLVRVTSTRSRSFSSQKANKNPLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0T9</accession>
    <name>A0A2R6P0T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000574">
        <property type="protein sequence ID" value="PSR82814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0T9"/>
    <dbReference type="STRING" id="98765.A0A2R6P0T9"/>
    <dbReference type="OrthoDB" id="10007484at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="37714" checksum="59307B2492B3DBA5" modified="2018-06-20" version="1">MGPDKDRRARNIAGDPYETLLQVKVTKYQVKAEPGIFGKVAAYFGTVEAQGRGTLHLHMLIWLKDTLTSAELLELLKSDLFRDKMKTFIKANMRAYCPGLESAESVKAIRSDQAVGFTRPPHLDSPTYAQDVRTLKLNLARTLQVHTCKIRRCLQFNKYGQLVCKRKAPWPTSNKDFVDETCQWGPKRLYVFVNGWNPWITIYARCNNNCKLLTNGRDMKNLSFYVTSYAAKKQGRNFNMSAILAEGYTYHMKYPRAKYVDSLRDMQQLLIFRLVHTINREQALSGSTVILYLMGWGDVYHSHQYTAAFWSLFVSALTKVFLEVYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P110</accession>
    <name>A0A2R6P110_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P110"/>
    <dbReference type="STRING" id="98765.A0A2R6P110"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="5">
        <location>
            <begin position="50"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR83048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="500" mass="54294" checksum="4278712E2A9FBEB1" modified="2018-06-20" version="1">MSSRSLAATQRARAIAQHMMASTQASITPSNGSAGPGEAPVLFETRGSIRKYILNRPQKLNALDTTMLNILRPYVEEWSRSNQNSILVGTGVGRAFCAGGDVAGVVQDASDPATRPEAISFFQREFELDFLLAALPRPYVAIMDGYTMGGGVGLSAHAPFRIATENTAFAMPETKIGYCPDVGASYFLSRVDGEIGTYLGLTGDVIRGREVFELGFATHFIPSRRIPSLLERLASLDDPTYKMIDRTIEECSEARNADDPAPSLAGPQRVAIDTAFAHNQVEKILESLKGMTESHENSAIRTWAQVTLDALELRSPTSLKVALAAIRKGKTINLQEALQMELNIATAYCSGASPDFHTGVTAVLVDKIIERPAWYPATLGEVSDSEISKKFFSDYTPTSGTSPALAFPEALDPAKGTRFSPVSFALPTEQEIRQLVDGSHASSGATAITLQELLNKLNLLRQGKMGIREKVLEVVERCCVQDEEKETGEKYLRWKSSAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P181</accession>
    <name>A0A2R6P181_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P181"/>
    <dbReference type="STRING" id="98765.A0A2R6P181"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="949" mass="104162" checksum="3DE1F5A879F930EE" modified="2018-06-20" version="1">MVVTRRAPAPPVPTSRTNSSQPVPRIKSKTPQTVPDVPSPLANGASRTELSYGSDKLNQKAGDESESLATKGKSKKGKQKKGHGKNSKGGTSFMELLTRVFLLWFTIYTLTVCPQDDTLKSPVCRGLYEYRRLVLEPYVLPQLQHALAHPVVAPYVDRAKPYVDRVIATAKPAALRAHSEWNSRVVPQWNKTILPQWNKFVVPQWERHAAPHVDHVTQLAQPYISMVKHEYEHKLAPHLRVAAFNLYKWQQQARPYVVLAAHKTYDGYQYTKPYAVPVLHNLQVFLARFTQFLGEQRRQFVDPHVKKIWERVNELSSGEPRPSIDVRDAFIAPVSKASAKLSSVPTSSQSLSPLVPKAPDAVLESASSVLPDVPSESETLPATVPSTNTAATPKSVAPTDVPAEDHASSVPEVGASSISSVSSSLKEDAPSLGSTASLSLTDHTTASAASIVSAGSSVVVQTLVPSASIIVQEPAVTAASLSEGLSSSMSSLGHSASSVYSGVSESVQTAIPEALSTASSISDDVRSSAFSLGSTATDLISEAASAISSSAPSALPSDETEDDDFLAKFYAELGLDQDLLTSEDDTSEEQEVPPAVDTESEEEREEKLRLKKLKTEKKRADITARHSAWEKELEERISLNRKALRKSLVALRKAAVQELKESVEIHKDVEGLVEEAEKYLKGAEKYLGNLSRESRADEEKRIIWERVVQKVDKKFEERLTQTEAVVNGWYLQVIENELQEVRRLVGEVRDIAGRAQADIGLDYAWLDDVTYGDWQRYHDLERRSENFAAQALSIHNGTHPSPPINPVIPALEDLQNEVQDVVVGFETRLRRIKRNGERAFGAAPEADSEADDHELHESASDETVSILPIEDDKHKDVEDGESPAVPPVVIGRSKEEILSALDRAAELEEHATSSPEDKYTEPEHVVESLVEEAVAEGHLSSRAPPREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1D7</accession>
    <name>A0A2R6P1D7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000574">
        <property type="protein sequence ID" value="PSR82813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1D7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1D7"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="24779" checksum="18DEF121C897F77F" modified="2018-06-20" version="1">MEVEDDARQISPRELVHAKHAIEVAKGARIFMPGQDTWMPTAAMVSNATGNDLTQVIGWQAQMQADVLCLNGEDGPVNRLDTAPENNGAVKRVDGLVQGGQASVEADASSPQGHETTGVLTAADPAMLKDDQFQSFDIVHWHLGKTLAGNNPPPLRMILYGEEGTGKSKVIQTISEEFVARGTQSMLMKAAYTGVAASLIDGKTTHTIAALSVKRKDAETVSDGVKNRLQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1I5</accession>
    <name>A0A2R6P1I5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phytase A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Histidine acid phosphatase phyA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Myo-inositol hexakisphosphate phosphohydrolase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Myo-inositol-hexaphosphate 3-phosphohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v5721</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77131"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84142"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1I5"/>
    <dbReference type="STRING" id="98765.A0A2R6P1I5"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="93"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="226"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="445"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR83449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="478" mass="51930" checksum="12EC5B0EBC37D95A" modified="2018-06-20" version="1">MSQRADNAEDLEEGLLTGTRRPLRTPFATRFALKKMLLALVILASIGLLGSMLLAHPKTLTPVLGLPANVQLEWAQYSPYIPHGIYSGPPSGCEITQLQRHGARFPTSGAAKSIVAAVIKLQAVKAYNDPDFDFLKTFTYDLGTNDLVEFGADQSFDAGQEAFFRYAELISTDNLPFVRSSSSERVVLSATNWTAGFSAASHHVYSPILSVILSESANDTLDDDMCPAAGSSDPQKKTWLATYAPPITSRLNAAAPGANLTDTDTSSLISLCPFETVAKGTKSAFCKLFEHEPGAFPGFGYSGDLDKFYGTGYGQLLGPVQGVGYINELLARLTETPVQDHTQTNTTLDSSPLTFPLNRTVYADFSHDNQMIAIYAALGLFRQPQVEPLDPTKPNPERIWRASALVPFSGRMITERLKCAGSKGDAKTVRVRIWVNDVLQPLEFCGAGEDRVCSLDAFVKSQEFARSNGAGDWEKCFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1T9</accession>
    <name>A0A2R6P1T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v5665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000555">
        <property type="protein sequence ID" value="PSR83658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1T9"/>
    <dbReference type="STRING" id="98765.A0A2R6P1T9"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="129"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR83658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="552" mass="62462" checksum="960F7A36E88BF223" modified="2018-06-20" version="1">MFHDPILTLCQPVAEDDKSEEKPTPQELEQLYIREMVEAFHAKPSEDEVITCSIIGIFEKGAIRSIDPTVPQSPLGTAACSIDTNSEGDYSPALTGSTLCSPSVSPTPSYTSLLSAAFPPSRQLCIEDFNVIRHIESGCAGSFYHTIDKITEKPFTLRVVKKGDKRIPFYSKLFEEQRIGKELISSPWAVGIQGSFEDSGNLYMIMDYCPGGSLASVVRNKEYDLQKVKVKLAETIVAIEDLHSRRIVHRDIRFENILIDQHDHAVLANFSCAMERDVPNDARPWESFSVWHKNARKYVPTATPTYMDPVDFVYEPQWTGTIGYMSPEVALHKHSYEMDIWGLGAAIYRMHYGIFPYQIKDYQRDLSDVLCRTLSERLDIADDEDPIVEDLLRRMLEKRPQKRITIDELKAHPYFADIDWALIYERQPLEPTNNEVPLPIPTDLDQPEFAFTPGEPYKAHAVPYPWFSYASPALQEPVFKFALEDIEKIDPLADDYDSSTLLSHILDSFDSVGLDGIGLSTLNFAQKETVWWKHPTAVEAGPRVGTDPTDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P241</accession>
    <name>A0A2R6P241_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v5549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02000546">
        <property type="protein sequence ID" value="PSR83998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P241"/>
    <dbReference type="STRING" id="98765.A0A2R6P241"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="40"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="240"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="749"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR83998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="799" mass="89298" checksum="A14A298525DD61C7" modified="2018-06-20" version="1">MASSSPSGNSAGTYPSIPAIRAKVQNTFNCRPCLWQCKVAEGVFRGKDVLVDVGTGMGKTLSFFIPPLFRPKGIQIIITALNILGDQNKEDLKRAGISAISISADTATDANFRAIQEGQFQVVIISPEQVMKPGGGFEKVLKCPEFLKNIISVIFDEAHCISEWGSFRPEYRQVSQLRHQLPRVPFVFASATFSSAILADIKAIFNLEHDRLVHIQRPNDRPNIHIGVRKIQHALASFMDLAFLIPEGWQEPDPAPPKFIIFFDSISDAVNAGKFLRNRLPPDFRHKIKWFHSEMSPKFKQEEAQRLHEGTIWGLCATDSFGMGVDLPDVLLVIQWRMTCNMCSLWQRLGRAARKRSLEAIALILVEAKYFDDERAKKTLNKAKKNARNLKKRKLTVDNTSHTPAKRTRQARTSNTLKPSTPVREILAPYQYANSNVPNLEECAIDPMPELPETDNSDDSWESEEEGEERKPVNGRTVEHDVITCSPVLQTASVEDLTAIRRQMYLESSKGKVLRAVVKKKDPDAELDIELMDLVNARERGLGCRRLPIWSFFSTTDHLLCDTSVSTGCSRCCLTPSTSCCDIHTPERFQVVAPLNVQRLPRGKRSTLPKTMHAVQHSQLREALCNWRAKKTAIEFSMSHLADIGPSLVLPNAILDRIVICAQVHKISTVEQLRKETRWTESVRYSEEILGIIQLYIPWDVSNLPNSGVPLPAQADACQIPSDTNLLSARPPNSARKAIKCGRCGEQGHNARNKNCRNNENIPPPTTPAASKSRQAPQQGSAFEHTFTLNLGPTTVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2I7</accession>
    <name>A0A2R6P2I7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000533">
        <property type="protein sequence ID" value="PSR84471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2I7"/>
    <dbReference type="STRING" id="98765.A0A2R6P2I7"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR84471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="337" mass="37095" checksum="162332B61BA5B94E" modified="2018-06-20" version="1">MKLQVRIGRIAGQYAKPRSSAMEKIGDREVLSFRKEFERISDGLSDALGFTRTIGVGMENAPYEKGGGRGVLGEVDFYTSHEGLMLNYEEAMTREFPLPPGVAQSHSKPLDTEARPKAFYNTSAHFLWIGDRTRQLDGAHVEYFRGIRNPIGIKVGPSMVDDELVRLLDKKYLPGHIAAVQKSGHPVIWICDPMHGNTLTSSSGLKTRHFGTIISELTACIRVHAASKSRLGGVSLEFTGELAEDGFSVTECLGGSMGLSEEQLGLRYQVRSPAIHANHTNVTCVNGVQSFCDPRLNFEQSLDVAFLISNHFKKERLGEYHENVDVLYAELGGQGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8M8</accession>
    <name>A0A2R6P8M8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000520">
        <property type="protein sequence ID" value="PSR87003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8M8"/>
    <dbReference type="OrthoDB" id="2751783at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13108" checksum="916FAB98A2E1D2E7" modified="2018-06-20" version="1" fragment="single">VWGVTIGTAILQTQLRKRLPPEFIAQFPGGVVIAYSAIPVISTLPEPAQSQVREAFAQSIIVIWQVMIGISGIGLLSCFFMKALPLHTQVDERWGLEESNKEKASDSDGSMHISELQVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC87</accession>
    <name>A0A2R6PC87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC87"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6189" checksum="D839232D771E58CC" modified="2018-06-20" version="1">MASRTGYNMNSSGASFGPALTARGIIDHYGINKLLSGSCRRHENSPTTLVRTTLLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ65</accession>
    <name>A0A2R6PJ65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000483">
        <property type="protein sequence ID" value="PSR92022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ65"/>
    <dbReference type="STRING" id="98765.A0A2R6PJ65"/>
    <dbReference type="OrthoDB" id="3238562at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR92022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="220" mass="24939" checksum="ACD0B69F73D67329" modified="2018-06-20" version="1">MSLEYRQRWNNSRGSYFHGLRSVEFSPSGKYLAVGGAAGLVLLKTENGQLVTLIQHAKVSAIVAGWFHSETLVCAFRDGVIVNVSITKGQLNISGLVSHRSVEELSLDPTGKFLATCTGTDIVIWKRSAEERWAVFQRIEPSCHTFPGNPESSVEISSIHWQEGGARLLVSYKFHGVRYYYTTLESIFRIIITHPVSKGMGYFRIHRYQYIQYEEYIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ91</accession>
    <name>A0A2R6PJ91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000480">
        <property type="protein sequence ID" value="PSR92131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ91"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR92131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8762" checksum="E1391B4A0761BCCA" modified="2018-06-20" version="1">MRWQSEAEELSIGAADIYFRALRRISQYRPFDDMRNQPRAWAHLTCWPEFDEPIRCNERCQPQPNGEPPTPATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMR5</accession>
    <name>A0A2R6PMR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMR5"/>
    <dbReference type="OrthoDB" id="2985494at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR93715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="491" mass="54503" checksum="F90A02AE211ECEB3" modified="2018-06-20" version="1">MASSSSFSASRQGDLHTLQDELNNTARTIIRLQTSFGAAIQKSEEREARLQGRIREVKAQKVAQDLEVQMLQRQNEELRRLARTQGGDSTRAGLEARVRCVTLERDDARRELKHAHKILFDLLREKKDIFSPEAARSSASQNRVLRSVSSFRDQPVESDAASSVSKAQGRAKDKSSTARLKEFTDTSFASTRMQRTHDVRKADEFVERPSTTRGKVDTSGTPVPNRQTSRGQSSTVRLEDLPGSVSTTLTPSHEAVVPDLAEEAEVEAQLAEGSSSEDAATSADETATSDGGHLTNVTYEEDYGVPEEARGRDLPPTPRSSIVVENVLSAAQPAVDGGEIQVEPEITDDDLAVNWSWTPATCPASAPFSCGPMSHAELSERLQMSEDTDGPQWWYAGKLRWHLTNRVPKWPTLDNGVILDEIATQLKAWLTKILKEKWRTGQTRREIAGLMDSGELRQLTIELRRDAELEEESRAFAQDVLRMPVVESQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN74</accession>
    <name>A0A2R6PN74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN74"/>
    <dbReference type="STRING" id="98765.A0A2R6PN74"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="78" mass="8375" checksum="AF9A9A66BE5C80FD" modified="2018-06-20" version="1">MSWFTNLFTPSKNTRNSRTAISSTHEAFSLPTSSPRHPNDAFHPGSPSTPDPMSAASPSTYSYPPQSPTGAYDYVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PND5</accession>
    <name>A0A2R6PND5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v4536</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PND5"/>
    <dbReference type="STRING" id="98765.A0A2R6PND5"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="46"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR94108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="419" mass="47427" checksum="05CD27F134805A74" modified="2018-06-20" version="1">MRLNLWRIRPPALRNAAFSSCPRCFSTDSHVNVLGQYYSKDSATNITASIIDKLDRKLHQQPAHPLGSLRSLIESHYPSFTHLSNFTPLVTPAKNFDDLSFPADHPGRSASDSYYINKDLMLRTHTSAHEVETFAKGERKWLLTADVYRRDEIDATHYPVFHQVEGASIFPTNPTGIHDLEEDNARLADYLKNSNIVIEDIPHITGSNPRQPTHDPRQAELVAQNLKLSLNSLMLTLFGGRAGVGGGEPLRVRWIEAYFPFTSPSYEVEVFFHGKWLEILGCGVVLQSTLDRANVPDSIGWAFGLGLERIAMILYSIPDIRLFWSQDPRFLNQFAPGNIVPFVPYSKHPSCYKDISFWVPEQGLHENDFCDLVRDVAGDLAENVKMVSRLRCDADLANKHYRLTRSHIRKREGTVDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNG5</accession>
    <name>A0A2R6PNG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNG5"/>
    <dbReference type="STRING" id="98765.A0A2R6PNG5"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20532">
        <property type="entry name" value="CYCLIN_CCNL_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="194" mass="21928" checksum="7C0D73D90BC3E42A" modified="2018-06-20" version="1">MSTLYPLASLVQIEKTPSNEDGIPTNLEEDLRAFGCKLIHQAGVLLKQKQVAVATAQILFQRFWFVTSMKQFGIGDVGMGALYLASKLEECPIRMRDLINVYDLLLQRTAHNLAVQTSTQHISDFKYTPMSYFGNTFYDLKDALVVAEMQILKRLGFNVHVVLPYGTLVNYLRVLGLTSREEVCTRAWGYLNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNP5</accession>
    <name>A0A2R6PNP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNP5"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR94676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="641" mass="72384" checksum="A929B634F1BE77B8" modified="2018-06-20" version="1">MIEENENAGYQGEQKTEANNLGKSGWSAIEEYLWNHDASTMKVFSEDIDNLLIFAGLFSAVLTAFVVQSYPSLQPDNSQLAVDLLTRISSQLEVSPLSMNSTASPMVSLSNTFRVSASMRWINALWFLSLIFSLASALFGIFVKQWIREYLQWNQPAAPPRENVLVRQLRSEAWDDWNVPVGIAAIPALLQLGVVLFVLGLIVLLWTLDPIVATIATTAAALLLIIAFTVTILPAFSHRCPYKSPTGWACVIMVNATIRLLQRTSHLICGYFRRCIEYVRQVVTIHCPRIIKRLSDIISPSLHSLSSRISRVYGNLVHERGWISLWLYYVFVWPFRLIWRLSKSVVNDRATPSFSGWRQRDLCVDLLKPGEISDIADILDPSFEEEVYALEDDGLSRNICQVIPLVRALSWVRKGSDDSRLLMNIGECVQSLHLDATASITRFYTYIYTLRKLSSIQRRLEPYAPFMEGLRTRLYRTVNVSHRLIGKTPSDILKAYIPVGKFCAQTGDFLEPSKYQLDSASAWVLSQLLFADVQAYIESILMRWDDSSFESLGGPCRAFNEEAEIPITLLCLLIQSDISEPSDSLQTRICVRLVEAYNSMATSSYHTLRTTGMQAIIWELALGRKYGKLCVVEGTNDLRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ21</accession>
    <name>A0A2R6PZ21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ21"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR99059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6417" checksum="CFBF38223872D90F" modified="2018-06-20" version="1">MHVKKLTLAVSNIRSAIPTGPLMNGMFSVSYVIEGLECNREMFKGIVAFRYARARKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7E8</accession>
    <name>A0A2R6Q7E8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000390">
        <property type="protein sequence ID" value="PSS03312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7E8"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7E8"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="179" mass="19947" checksum="955CCF4AED3F131F" modified="2018-06-20" version="1" fragment="single">VKNEFQKIREIFKHRVQIYDCEGANPAAVLKDLHTHPWVHFACHGSLNAKAPFDSGFVLHNSERLSLRQIMQANLPHAELAFLAACHSAAAESRTPDEALSLAAAMQFCGFQSIVGTLWTMADSDGPTLAEDFYKYMVRNGPEQATARDSAMGVHRAAKAMRERNVPLERWTTFIHLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB58</accession>
    <name>A0A2R6QB58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB58"/>
    <dbReference type="STRING" id="98765.A0A2R6QB58"/>
    <dbReference type="OrthoDB" id="2564267at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1027" mass="111697" checksum="B42E7625A9424009" modified="2018-06-20" version="1">MQEEDGQDGGDESERNDEVGSKEDLGQDDRLEGRQNKENNVVSSNEEYDNDNPDPDLPRRRAEESAIFAHLRRTPRQVVQAARRSTDYLGVTLPTDAGSINGGESISQHRKSQQSIDALRNPFGRDSTHEGHVDDDEIEVDLSSWGLDAFGAEKGSKKKKGKEEPLPNPYPPLQDAARRRPAASARTMSMGNLDNFGEGGAFLDAKSSVPIRPLGARRHSVGSPLDYVDVEPTESGLQHRRRASAHALIDSLPITPPLHSVPFPTATSVRSVSPLLIEGGPSALRPASRASLLDPKHGRTYSTASMGSRALLNEEEIPNPFAVRPPSPDRASRFDPKAVRARTVSNGTLGTQMLLNEPDAEIPESMSARSVLGDQPGRSRPYSRLELMRPKVLIMPSPLQGSSSQQPTTPAPEGFMVNTTEGPPLPPGARTAVSGRRSSFTMSMLDSSNSLGGPSPTGFTLSPNPRNSMTLSQLTFRNTLMIDGQRDVAYQDIDDHLRRATEDGQQADLVAEETSKTSLPVIEEPGQHGRPAGRLYGKSLIDDLQARKAEMRGKQRVFTGDQRPSMMARTPMKRSSTLIDPESLKQRPVSRRLDSFQTTPDLSRRNSAGARKTLINFEDEIPGAPRGAHLGIDNLNAGGQTKSVFGVDTLWERELAKLKEIEAQEKEADDERKQREAEIDATGKKKKGKKRKGKGRDEDKPNDEGLHTSESKLSETSPVPDLTTGSAPGLSPVSSGGINKRGALKRPPPPPVDGDEDEEEESDSSSASPRGQAKRTETNGWYSGSDDERKPRQTASAPGPVRTTGAGPRYPNLPPRLQALHDQGQLQLDDDDSSEEDLPLVATIERAAQRATRADLRSAADDSSDEDRPLTQLLDKTKLKLPTLSVGGSMFGSATKGGDESEEDEKPLGLRVSRLVPSSHALSSAGPGGEDDDLPLGLHPEQMRRSQFMMAAQVAQQQQQMMMQAQMHQSMMFGAPSIMSAPFYGPPMAPPMMMAPQLPSTPPPLQDTTKLHRVDKWRHDVAVEGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEC4</accession>
    <name>A0A2R6QEC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000365">
        <property type="protein sequence ID" value="PSS06491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEC4"/>
    <dbReference type="STRING" id="98765.A0A2R6QEC4"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="117"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="311" mass="36037" checksum="25B3D4A471F0B502" modified="2018-06-20" version="1">MSLSYTEFFECYMKTNRPVIIGADLVSSWPAFVLWTTIREKNTCLPGKEINWDYLADRYGHHEVTVADCATSDSFGNLECTSSPFIDIVNKWKCGEGRSLYVKDWHLALTETSEAIEGSKKSQAFYITPDLFRDDWMNSYYTAHTADDFRFVYVGAAGTFTPLHRDVYCSYSWSTNVCGRKRWWLFPPEQTPYLFLKGRNVSVHDVRDVDLTRFPEYAKTTPIVVDQEEGETIFVENLTACISINHNWCNSVNLPSLYLSMCDKVVEVEEALEDVREMLITSQDNKEEETEWKREFVKIVQDVVKQDAGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM96</accession>
    <name>A0A2R6QM96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM96"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS11048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="116" mass="13073" checksum="D17B3CD8CE79BA3C" modified="2018-06-20" version="1" fragment="single">LYQQFKEYNPGHGRTTLSSLPCAKQSRVFLLRQNRAEDTLSRIIPESPDNSTMPKPLARREAEVAPCIFGEPTLTESLPPPLPGTLVITIANDRNLLMMVVFSLVVVLCIIERRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0W6</accession>
    <name>A0A2R6R0W6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000287">
        <property type="protein sequence ID" value="PSS18889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0W6"/>
    <dbReference type="OrthoDB" id="5083627at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="557" mass="62066" checksum="B227C3360CA027A3" modified="2018-06-20" version="1">MSANLASYLKGMHSQSVTCNWDVAVTYDEAKINALLADRWAQPGSDMTTEVDIQEKTDDRLGEYYQNYQFNLGPPLIQFQSSSSNPTCSLKTPIASGSIWVSEIDDPDTKENEKQLNPDTYWITISNIHLSALDGNAEPAGTGDDTITFPANDESDRYIVIDIPITGENDLAVSVDYPYDYEPPTAMKQAFLETALKQFLKKKTNAFAYRLASINNYKPSSGTLDLVPQAFRFVTYHYASDNSSFLTLLVQTKGSSSPGDTKDVQAEWVTTWTNRAKVPPVPSTQSASIIINNSFFLQSFVRPALRSQTTSMDDITITDDIGGIGLQCQWPKQSREQKNYSQGYGDITSWPLDWKWSELHVPEAQYDPNNGSPLMLTFSHSNGFDKPATLHIYWQYKYKSTWNGVQIKRFWLKDPDGPGQWVPDTKKCDGSFNTTYTLDKTISLTDLSDEDLSINVDARSDEWRTDPVPDAGNGFWGDISAVFGGTAHQGDIPSFVKDTTMGGIEFTLSFGKLRFFSVTNILLPGQKVIDVNIKNGLCVPRDCTILGNVVEPANIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R758</accession>
    <name>A0A2R6R758_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000277">
        <property type="protein sequence ID" value="PSS22604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R758"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS22604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="8935" checksum="7E70A8134EAC65A3" modified="2018-06-20" version="1">MSVYRGPSLNIFNEPATAGRWSPPMTSDVLEPNSVCISKTVLNVLGSLRRKPGMKLQADPPLLWTFAEFIYGLNKGPRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7B7</accession>
    <name>A0A2R6R7B7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7B7"/>
    <dbReference type="STRING" id="98765.A0A2R6R7B7"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF140">
        <property type="entry name" value="PEBP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015327464" description="PEBP-like protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS22663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="27855" checksum="4763958142572AA0" modified="2018-06-20" version="1">MISVSLILSLALAPFVLGQSNNSELGIEAIEAHFTNAGIVPSLLASFDPSAVLSLSYNGVGNISPGQALTNTQVAPVPDLLVTPANSTVQLTGNYTVVMADAGPVGTDESQGQTRHWLVNSVPLTGDSSGFNVSTSTGLAITDYAGPAPAPGSGAHRYVILLYTQPSNFTAPDGLNTPGVAVSTFSLSDYVKNSNLGPIVAGMYITVEAGTASFTPSSTAPVVTSTLPAAQSTGSTSGTSSGSSNTASPTGNTSSNGAGNVFASLSKTVVAAIFGLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI84</accession>
    <name>A0A2R6RI84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI84"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6595" checksum="98E629FCA67C514C" modified="2018-06-20" version="1">MDYHSAQNVHTHVLRKSNKSSDDAALIEMIAAIRITKEQSRIVQPAADVMSEIAFEDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RII3</accession>
    <name>A0A2R6RII3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M24 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000251">
        <property type="protein sequence ID" value="PSS29829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RII3"/>
    <dbReference type="STRING" id="98765.A0A2R6RII3"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="8181" checksum="A0255F656B41D9F4" modified="2018-06-20" version="1">MVRLILSQLSDEDSDGLQCPMHKNLVDVGLLSVSERNWLNSYHEEVWDKVSPLLQNDSRALSWLKRECSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLP4</accession>
    <name>A0A2R6RLP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000233">
        <property type="protein sequence ID" value="PSS30932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLP4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6059" checksum="BBA68520E58EDBBB" modified="2018-06-20" version="1">MSAHETPSNKAAAITQQDWAQIDNALEDMNIVKGDDSPETTLAVSNAPPAMFGATGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLT2</accession>
    <name>A0A2R6RLT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v2481</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000229">
        <property type="protein sequence ID" value="PSS30993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLT2"/>
    <dbReference type="STRING" id="98765.A0A2R6RLT2"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="256"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS30993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="479" mass="54054" checksum="4CB9242BB5BCB6B0" modified="2018-06-20" version="1" fragment="single">FNGWGVTMYDALDTMILMGLDAEFARALPHIQNANFNMSVPGPSTSPRQQPVQILAPFFETVIRYLGGLLSAYALSREPILLERADHLAHLLSPAFDTHSGLPVFGVNTVTGRISSGTIGILAEVASCQLEYTYLAHLTGKKEHYDRSAKIMLALEQSISKLGMLPQKFNLTSGLPIDETLSAGAASDSGHEYLLKLYLLTAKSDETSLDLYIQTVNRILTTLLYVSPKRGLLYVTDIFNLQISPKPSRKFEHLSCFLPGLLALGAQTLPDSAFRRSLPLFPDQQELVHHDLRELHMLAATGLAESCWLMYADQPTGLGPDEVLMQQGELWIKEMQKWRKRGRRGIPPGVGEKEPVHSTQMKDRDYALRRPSYVLRPETIESIHLMWKTTGDVRWRERGWKIFEALQRETKTAVGYSSITSVERLGAPRKDEMPSLKYLYLLFHEEDLVPLDKWVFNTEAHPLPIFSWSSWERSKFGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLX6</accession>
    <name>A0A2R6RLX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000222">
        <property type="protein sequence ID" value="PSS31026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLX6"/>
    <dbReference type="STRING" id="98765.A0A2R6RLX6"/>
    <dbReference type="OrthoDB" id="3269405at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="423" mass="46948" checksum="B3312465F50ED74E" modified="2018-06-20" version="1">MADDSAWVREGNDAPLVGNSAQLNDHWMMENGLIGYSDMFSSNNFNSPTNFYNGPAFQFQDSMVADYSNMPNALGLDPFTAAHNAQTYTGTHMQSFHPSEHPSPSHGGRLPLPQIKTTDLRASPNHFLYPRSPADMFVDSSTGPRSALTSCSPSTAGHSTLLMTPASLPAQSQLSLPYVDGSHLSPSSPYRYPSYRKSPSPPKSPYSPYLAPHTPSSAEYSPAEGSASPYNLPRLSINANAQTHPTVYELAGQWPNLNKMIPQKPYRPHTQSDRRRYVEEVELEGPIMFYMANPAACGIPLKDAVNCKFARLDGRDDQMFVQCGPSISIRLMWPGYVSWSRQIPTRDFRSPPGPITRSKLAKNVAKTIQRFIDEMKTRPMEDADPRWKVGIKGINIDDLELVGLQHVSKGSWQAHLRLRNGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPU1</accession>
    <name>A0A2R6RPU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000202">
        <property type="protein sequence ID" value="PSS32043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPU1"/>
    <dbReference type="OrthoDB" id="2590620at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="228" mass="22502" checksum="76FED805A4EB1EDD" modified="2018-06-20" version="1">MPLFGQKHAAGQGTAGYGNQAPVGANTANNARTDPMLAGGGNPAMGSAMPGSGAGAGAGGHGHHHTAAGAGGHQQGMNNNFPSGGHNNNQGNVDPYANTVNNNQVTPVNHFSSGQQSGTGSSVTGKVERAIGTLVCSQSLKAKGIEKEREAQAKHSQSVELAEAERLEQEALARRGRAVGFGAHPANNALGGSAQAQEYGGNFGQAGAAGTGTSGANSAAPMNRGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVB8</accession>
    <name>A0A2R6RVB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000175">
        <property type="protein sequence ID" value="PSS33972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVB8"/>
    <dbReference type="STRING" id="98765.A0A2R6RVB8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="404"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS33972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="621" mass="67498" checksum="38B49E2FDE3FB043" modified="2018-06-20" version="1">MPIMLQSALTSNVFIVSQMLGTRFPDNLLVRLLGVWEVMVGHREGSMYKELKRVVPTAVALGGAMLGLLSVAADLMGAIGSGTGILMAVTIIYSYWEIGMRKAGAINAHIKNAQIILVDSFDEPAKSLAAVWRDKVVLDVGWAYQAIGRGSYQGEDEDWGGHCVCGDSVDDGVLPTYASAKSPLPTPRQMPTQRTTFSHVESPASSSRIPRRSEIVAGPSTSSPQSLLHPSTSSMISPPSSQAPNLVDGWLLQHDIAPSQRPPSILPSMPSQLTENAASSSQQQSLSGTFITPGAARALVFGMFGQAFGTLLLQAVQHHETNSPYPYSPIFQSPSPAMSNTVHPYQDHRDETVSARNSVPGPSMTPRMKEKRRETFMEPIAKRPRLSTGAGLQPIFRAESGEPLAFYVSMDLNNRSDIVDLIKKNGGKIYVDIPHADIVVLAPHKKPFADHLMAAVTARKPAVQTTFVHQCVLRRTLLDPGDFSFEGVEAKNRKNQAFTVCLDDLEDRASPPRKSKDGRRKKRSSKSTGSPTKASPSKQERSLGAEPLVKAEVQHTLVASGGDPCRSPSPILPTRIVEIGGGRNAFTDEDKEYFRKYVTHLLRRDPQVLTGTIARELGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZR6</accession>
    <name>A0A2R6RZR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000121">
        <property type="protein sequence ID" value="PSS35525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZR6"/>
    <dbReference type="STRING" id="98765.A0A2R6RZR6"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="550"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="592"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="634"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="675"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="717"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="759"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="801"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS35525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="840" mass="90826" checksum="5A9CE5C8A65B46F3" modified="2018-06-20" version="1">MGIAADVFAEQLAHYGHGRAMWSPEPTEGPDYKMREVRIGDVGHIDEDGAFHRLFNVTVDEDHPYNSGGVPDNFVPLKFNKRLLAVKPRLLDPGAYCSNSVKSKSVEGSASANPGIAGGGLAYRFECSREQGAMFILNDAAKKSSVQPNRDFVAYMREHHESWYNFASSSDTYGLQCKPEDIILVRGAVKTTAWAVAAFIESGSHVHDVSFNGQVGPVASAGFRFASSRATHSSFEHRTGPYRAVSSSNSLRLTHSTLSAASSVSSKSVQSSHAELPEILVEREKGIEEEKLAVPCDQCLFLGHYKIKYRVFFGKKVIANAGPDELPDHTDDDDPNMSISIAGDFSEAHIEIVPAPSERRSPLDDVLEYILEHSNADVAITSDGDINDLFNVAGILSIEEAIKRSHHAAVAQQNVTIAKMELDAFVASPSHATERGATMNVSEEGSELGDSQDESDEAFENHFPPFPRHLAELGATGSCVVNDGQLILGKKGPNSQPINWPHTVLFDKTAEGGSVTSVSLSKDGHFVATGSEDCIVRVWDLESGLLVAKLEGHEDTVWAVAYSPDGSRVVSGSADRKAILWDVDRRIEITELEGHGGDVWTLAYSSNGKFIATGSVDCTVKLWDGRLGTPLTTLEGHSAVVMMVEFSPDGLRLVSCADSVGHIWDATNGHRLGILQGHTGVIWSIAFSADGSRIVTGAEDHTSRIWSTENGAELVTLREHTGPVWTVAFSPDNQEVASGSYDAMVAVCDSYTGEQHHILEERPSIVNIVEYSPDGEYLTAGCADGGVKVWNAKSGVFLAEFQGHEDKVKTVTFTPDGNNVISSSDDGSVRIWSMLDVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S383</accession>
    <name>A0A2R6S383_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S383"/>
    <dbReference type="STRING" id="98765.A0A2R6S383"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS36747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="78883" checksum="8EB027C90D88066C" modified="2018-06-20" version="1">MALIKTEFASSSGESHASSPEFEHPSPDMAASAPNASPISLPSTLLPTISAETDRDQRSSRSTPTRSSPTDLARSRSAGRGGCWYKCDEERVENDSCRTCRRLGIQCLGWGPRRPDWMRDKEKVAEYKAEIKAQLTRAGLIRGQPRAIYNALANPSSTVTSATTSTTSILPRRSSSDRFPQSAVAGPGPSTTGLRRSRTNEYNVYPTRYASSPHFQQSTNLISGIPGLGAGGATSDISIPSPFVVANSSFNHGSNAYTTTEIQSISNTSYPTFPTGAEIPQTLSPSGLYVPELPLADQECIPYYFAHVRKLQFVFAGHSLTDTLYRIASTDPQGALSYALRALASLHSTTTRVAHGLEAPSSPGHTVHKHYYDRATYILSNVKTLGGHYTEFHAIAAVYLISYHILSGNGGAAWAALLEVAYDWFALTGIHEEQNPKLMLVNMNAPQKLAAKATMWIDILSGVTFLRPPRFLSVYRRLFGGGGAGYWSTSNNDQLDLRMDKLTGCPDEALLAIAETAALAHWKASESRQGSLSMRDLIRRGDQIEQVLRQRPARNYAESPTSETVPVMPSGMTAAAGMFDDTTGPDETTRRTVAEIYRETAMLYLHTVLSDSHPGVPEINKSVNTLLDLIQQLGPSQFDRAVIFPLGLTGCMTADPFYRLMIKDRCNLHPLDFYCNGHIAQIQQLMEYVWTTRDSQRGSVPVDWRECLHERWSNLLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3A3</accession>
    <name>A0A2R6S3A3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3A3"/>
    <dbReference type="STRING" id="98765.A0A2R6S3A3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="12277" checksum="67DF811442B910A1" modified="2018-06-20" version="1">MGTDYYKLLGIGKSASEDEIKKAYKKAAKEASKKFKEISEAFEVLSDKQKRTIYDQFGEEGLKGGGGPPPGAGGAGGFPGFGGSGFPSGGSTSFSFTSGGPGGFGRSGGFSPTDPNKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3H4</accession>
    <name>A0A2R6S3H4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3H4"/>
    <dbReference type="STRING" id="98765.A0A2R6S3H4"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS36822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="362" mass="39147" checksum="77D257A7A8C200A1" modified="2018-06-20" version="1">MSFPSTIQAVTIPKTGGLEVIEKTSLPFPQQKPDEVIVKIVYGGVNTIDTYFRKGLYPVKSFPQVVGVEASGIIVALPTDEIILNDKWYQLRKYKIGGKVAVNGLGAFAEYVSYPWKSVFPMPDELSLEVAAGTLSHALTVVTTMTESYDVKKDDIIFIHTVAGGLGLLFTAYAKSRGATVIGTTSTPEKAELAKSYGADHVILYTQEDTVKRTLEITNGEGVHAVFDGVGKDTFLADFDILRRKGTLVAIGNASGPPGPISPLKLSAKNLKLLRPRQALISTSLIARVPNRLFSMGNYITTPEEAHHYSQEVSNALKSGLFKIRICSVYPFTAEGVQEAQREITTPGGKLAGKILIKIADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4N5</accession>
    <name>A0A2R6S4N5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4N5"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="386" mass="43693" checksum="94B66E2346F73F08" modified="2018-06-20" version="1">MSFEKITLNVRLSYEHQWTFAREFHVSPFNDRSGFYRVSVTLPPNPPSSSITEMCEQDSLHPIIQVHLYTGNTETFPAQGLGPLKLTAVLRPQSLIPLTSINLLRALLKHPFLLFLSLPRILYQAWILHYKKHLSVFPRPEPHPAASRWPQRDKPSGGVGWQSETWLQSFARRRAVMFLEHCAQEHDVAVKLIAADPSTLPLEFLPRGRPKGQILSIYYLSPAFFELLLATPSADHALFLGASSKLFTVSSEESFLLVFRGFVEKAARSGSPSFLQRLRIRQIPTNLFDASEFPIPDQHTLDPPAACTVIYFSTLGALLLSFLTEKLEELAYRKAAVRFAPGQEPWKKWESAWAAYQTSHDTNSEENIVEKNDVGYLLGSVSTNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S520</accession>
    <name>A0A2R6S520_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000046">
        <property type="protein sequence ID" value="PSS37387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S520"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="8290" checksum="4BE49073A8527903" modified="2018-06-20" version="1" fragment="single">YREKVRSICLLPLINMNEWLLAQDGYTMEELDVYGVVDGKEAVVVHKTAEIPKLKVLRRQERQPIVHVFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S564</accession>
    <name>A0A2R6S564_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S564"/>
    <dbReference type="STRING" id="98765.A0A2R6S564"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021600">
        <property type="entry name" value="TFIIE_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11521">
        <property type="entry name" value="TFIIE-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="481" mass="54440" checksum="FBF8B281573B939C" modified="2018-06-20" version="1">MSSLSKEDQETLHLLVQHVLRAFYEPKYTVIMDQLARHPVLKDDDLAGRMGLQLKELNKIMAVLENDKLIRVHRQNELKEGAQRSVGRQYYYIDYQHFCNVVKWRVAEMRRKIDTNLRNQLANKGWICPQCHKSFSPLEADKLMDFAAGTFNCDICRAELVDNDNAENVRGSEDRMQRFYRQMKFVLEGLRKTEDMVLPAFDVAVWVRKNILDAERAKAAAQGGGLKIAGASGDGKQDDAIGIVLSVDKDEATQKAERDREAAAKRMQNILPAWHLKSTISGDLTALGIRENARAEEHIDMERLPNSNDAILRGLSRPQEAPMRLVTEDEKPGIPQRTDVDYYDHYYASLAASAAPSAHDTPALTNFNEFGEEDEDVKPSMEYLNSLGDYRKRSRSMEDIGDAGPAKTPKLNGQSTPNGYASLEPETPSMSLEEVPQEPLDDPTIYVNGQPIPFSQVTEEHQELMTPEEYTAYFEVIQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5A2</accession>
    <name>A0A2R6S5A2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5A2"/>
    <dbReference type="STRING" id="98765.A0A2R6S5A2"/>
    <dbReference type="OrthoDB" id="3249663at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="543" mass="58769" checksum="41883511AD8E9E83" modified="2018-06-20" version="1">MTEYTTSSEAIREYLTSRERTAHWIRDHFEDVSDDGNLLSPSAPPSIISDSDAPSFGPSDSDAESTNSLPPRMILRWNDGRPDVPISRDIGYPASRSQSRPRSRSAAAHTPSAIHHQPSHHSRSNGGSRDEAGTAVPLQPSRHAQTLSYMSGPLLNPPLNTHITPPPSPEHIVVLPSPQGEEPPQMASTSSSSSPNAPHPEYPLHSRTPTSHSAHHGFPPEGSVPHQPSQHHSIVSPHPQHAYNPSHTSRHTTRSPQLAYSQSQPLPAPHGQTRFYENHAGSRAPSQLPYNYSPPAIVYAPSSRHAGTRYAPPQIVYSPPSHSHNSHGSHSRNPTPGSIKYSHSAPLPQTQNPYHPNAGGPHQGQYPSLRGAPSHLSSTVVEEDPRDLDYSRSRSRGQGRSQSRNHRSVSKGGEMNRGRSPGRVLAIARSPSGSRSPTPPLSDAGSRTSGSTYYILPTPGQKVQIIHPGAPSMYTATSATRANHSPHSPHSPQSAGSKKPFFQRIFSIPKFASSIDSRGSSGSTGRKLHRRHTLGGPHLQQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5R7</accession>
    <name>A0A2R6S5R7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5R7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5R7"/>
    <dbReference type="OrthoDB" id="2775633at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="151" mass="16299" checksum="6E336648E31530E0" modified="2018-06-20" version="1">MGGGEGKCLYIDTEGTFRPVRLLAVAERLGLNGEEVLDNVAYARAYNADHQNQLLVTASALMAQSRFCLLIVDSVTNLYRTDFSGRGELSARQTHLGKFLRTLQRLADEFGVAVVITNQVMSNPDASAGPYAGNEKKPIGGNILAHASTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6T6</accession>
    <name>A0A2R6S6T6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6T6"/>
    <dbReference type="STRING" id="98765.A0A2R6S6T6"/>
    <dbReference type="OrthoDB" id="3239507at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="759" mass="81719" checksum="0D1B2F27F378A9C4" modified="2018-06-20" version="1">MEAARRHDTVRAEIFGLIKVRQEERKKTEFKYEPGKSVDVEFIIYKPSDSSEDTDRARQGRMCNPTVTPRTLTLYNDSNFEEVLWFFSRRDGNSHNYISLRDNPHFYHNGKVDKFRGKPNSFQGKLEALKQPYPFRDSEKHIYRVYIDKKHRILFNIAGTHRIFGNIWKEEQEAGKKEGETIILKEFDGTLVTSTALEGEYQQVKEFTIKPSDESRISAHRLLWDEVLDEAATYTGSGLYQIEPIMTMPVPAPSEPEFPVPSVAVIPFLSPVTQLFIPADIPLESRGVDGSIAVTNDPPLRKGEGDISNQASNGVTQNPSLHSPAVEPTQARTSSPRKNSGDDIPQAARTAIGPSPENRKNRSSELPSRKPPSTASNSQPTTVRDTPAMPPVVSSASPSAQAAKTSTIPDVRGSSAARNGDLPSNVNTSRSPPANTGSTTPKPTVDAAVSQTPIAASSSPATQLSIPAYTPSENRGVDGSTTITNDPPSRKGEGDILNRTRNRVTQNPSLHSPAVGTTTPSPRKNSGDDTPQATRTAIGLSSENRSSALPSRKPPSTASHNQPATVPHTRAPAMPQVGSTASPPAQAAKTSTVPDVRGSSAARNSDLPSNGNASRSPPANTGTTTPKPNITPVSAPSPGHATTPQTTEAPSTGYFGRIRRWYHPITDALGLTKVSLYPSINFSLLLTADSRLVIHLVLSGAENYLNSSGLLCDGISITSQVVAIICAMIRFKNSKLQPSLAIASFHVPCKSSLGCPNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE30</accession>
    <name>A0A2R6NE30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v13497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001342">
        <property type="protein sequence ID" value="PSR70637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE30"/>
    <dbReference type="STRING" id="98765.A0A2R6NE30"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR70637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="29271" checksum="A93215FB6490A7BF" modified="2018-06-20" version="1">MQTDWSRFYSPGAEVQSYLKDVVERYRLGPYIKLRHEMTSARYDESTGKWHIRLTRPSDTGDLDEFEDTADLLFLGIGTLSRWSWPDIDGLEEFKGPRVHSANWNFGGSTWEEDVQDWKDKNIAVIGLGSSALQIVSALQDKVGRLYNFARGRTWIIPPFITDIFSDLLSRDATTDENYTFTDEEKKALNDPELGERFRRSLEEAMNDLSHGQTSHAITLRDTPLQRASREQFREHMLRKLKDKPEVAEKCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NED8</accession>
    <name>A0A2R6NED8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001337">
        <property type="protein sequence ID" value="PSR70649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NED8"/>
    <dbReference type="STRING" id="98765.A0A2R6NED8"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="15580" checksum="50AA62A0454CB57C" modified="2018-06-20" version="1">MQNNNDWKPFSSQIAFELGEFLYKEEQMSQRKINKLLELWAALLLEHGRTPPFASQQHLYDTIDTITVGNIPWATFSLKYSGEVPDGPIPSWMSQSYEIHFRDPHLLARQQLNNPGFKDGFDPIPKRDFDRNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEF1</accession>
    <name>A0A2R6NEF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEF1"/>
    <dbReference type="STRING" id="98765.A0A2R6NEF1"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="205"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="939"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1130" mass="123562" checksum="945AA21A2FB41759" modified="2018-06-20" version="1">MASSSSANTPPALLEATRNSTGTWQDDFQALFDDAKDRYPDVVWELLNDEDDKSKGVEEVWGHKAIVYARAPPTFQARYFQFRPPPATSPLPYSSSPTGTLPAQSALSLTLGVDFGTISRSPSPFRVPSPSPSINNGPLLRLTTSINPTLFSNELEYLYTGKGFGEAFEFLFDTTETREEGDGAEARIDKLRKDLVFMWRSRLYSDVRIALTGNFSSTNHDNTTAIFSSHRFILVSRSPYFCTQLLQWGVKPTPGEPLTLNLPSPPFTPASLHFTLGFIYTGTLIFSHRTFDLDTSFHIMRSATYLSIDTLYDEIQARIVQEMMHGLFHAFLEFSEYERITGGKWGTGGCRCRQCARRAPRVLEFALSEDVKNPHLERGARRALVGLFGEGWCNPEFARLPQKTRNSLLAGLAKRTTPMNVFPLLFASHTALAKIDGVIEPWADVAKEMTLAARKVIDDVICSQAEQCFEQGDWLTIMEADGARFEDGEKVEWVMESIRRGMNEKNAGTLYQILVSSILLRPHLTETGETMLSSTSHVRVQVEQTRMDLIRWLRRRWINVKQEGGFDNLDGWAVKEISHEIEVPVEDLFSLMPSATPKATPTRSGAQRNPGAKAEDEAASTHSVRASPLHRNVGRAGGDPVRSSAASVRSTVARSTHSTVSRLSTATTATTTTATTRRNVHSPGIRPDSKLTPGHTRQSTTASTRSTLVDPVSNSTPPPPPKQALPGGVPRRHLLSSASTGDSPRSRSSTASFKSTRSQASTVRKTIAGPSTLRPPSALSRPGSTMSTTSDGSTNFETAKSDVTPTTAARSRRVSTASTVSTVSVKTTGAVSSPRITKSRPPSVASKVSVNGRRPPPSPVDNKKLSPVQAKRTLSTASTRSNASSISTPPRKSVARNSGVPPPLPPKNDVSDTPKATDPGDTIKGKPKRVAAISHEKQASVVSSSSASTVKGSLKRKNSTDTITELNASDSSPRDQHGVPRGATLDIGIPCIISSKRARFRAYARYIGEVEGEFGPWVGVEVPVNDDWPVDKLEGRQWNDGSWGGIRYFDIGTSSEWEYGDERATRRRRADWASNYSSHSSLKREGDQLSIDRAKRLRSVSPAVSDISNSESRGLFVRPQQVLYVVDAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEH5</accession>
    <name>A0A2R6NEH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001323">
        <property type="protein sequence ID" value="PSR70780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NEH5"/>
    <dbReference type="OrthoDB" id="3267102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="235"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="646" mass="71463" checksum="123FC85E19E07396" modified="2018-06-20" version="1">MSIESPSSSVSTNAYIFHDGEGNQLRIFTESTIQGRPKLVASLKKAGAINAHIKNAQIILVDSSAEPAKSLAAVWRDKVVLDVCWAYQAIGRGAYQGEDEDWGGHCVRGDSVDDGVLPTHASANQTPPVDVMNDSSAQLQESVPPSLSQGHASSPYPSSPIFQPTSPAMSDTVHPHQDHRDETVSARNSVPGPSVTPRMKEKRRETFMEPVAKRPRLSTGVGLQPIFRTESGEPLAFFVSMDLNNRNDIVNLIKKNGGKIYADIPHADIVVLAPRKGPFADHLMAAVIAQKPAVQATFVHQCVLERTLLDPGDFSFEGVEAKNRKNQVFTVRLDDLEDRASPLRKSKDERRKKRSGESTGSPTRASPSKRERSLSAEPLVEVEVQHTVVASGGDPCRSPSPIPPTRIVEIGGGRNAYTDEDKEYFEKYVTHLLRRDPQISTSTIARELGKKVRHHSPKSWDTFCGRNGAIIDKLRRKALQSEQSQRQGIHTSLAEGTPQSSDEQNVPASSMVNSTHLAQHMSSPSLNQPQPLPLPRINRPQPSVVNQEALEDEDVEFLTQSLLDGIQDDLSDDEEVWPVLTKLVSLQNHFIVASQRCLRQLGSKRRCRSAPTWKDLWNKRGNDIKQKWTQRMEDDPKVKIEGNDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF06</accession>
    <name>A0A2R6NF06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001301">
        <property type="protein sequence ID" value="PSR70936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF06"/>
    <dbReference type="OrthoDB" id="2020419at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69358" checksum="8B73553CC4B79169" modified="2018-06-20" version="1">MLRSRSMRQPASWTDSDKTLLPSISAAPSESFGDEQASSPRRVVLRRGNSYTESESVWKRPRYQILFLFLLLASSTGLWLLHSNGSPATHRTADSNPLRDTTDFLPIGELQRRLAPKAKSSLNSRPPKLNREILLDLVEDETERPQVRGPDIVNVRWPPVVTAVPEVRPSEKALRSGLTTSSVDAQFCQGQSRCRFLLPLWIGEQESRGRMHLTQVLHLAAALNRTLVLPNVGKSRIGACGKWLFDAYYDLGSFAKQAREVFGVPRGTIMLDDFKTWVDMRPKAPAGQLVFFDESSTALPDGLDGTLVTAEDGLEVYVDHHPLAHDDTRLKNARCLKWKFNKMRTDTHHPVSLRLPTLGHPAAVNPGETLVRILQREDIAQMSVGNLQDFGMIPQDVLDFGKESPLETMATEDAEVLLVHWDLRHFPFSTLSTTPSGPDYSQNIRALADKLTKPHQPYVAIHWRMETVPPALLPDCAEALVDSLSILLADPTLAEGIRSVWLATDLALSSSSKLQKDSVQRSNTFKTVTSEHTEAIEIVKMAFGNGGPLEAWELTGLAQEIERMKRDAEAYGEEFVLEDEDDSGLLWEDSGVWGILDKIVAMQSALFVSGARGCGRVRYVQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFD7</accession>
    <name>A0A2R6NFD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001296">
        <property type="protein sequence ID" value="PSR71031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFD7"/>
    <dbReference type="OrthoDB" id="2646484at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="666" mass="73027" checksum="D22A46097ECA0BE6" modified="2018-06-20" version="1">MAYPRPIVPCGSDTSLKLNDPKYDSGSLLATSLTFDSSLDSTHSLTEIPPFPAHISRPIFVNLLTLPVFSSRIFEASSTLYTVTVPTSPRLKSLLMEPISVANWTKNICSEPQVAAWESELISDKVSKPWVPEGSIVPPEFFRAIFRPQRVVDESLVFPTEVKQDSTEFSLCVDASYTPGSDHEQEDQLIVYPGDEDCGARALTVPTIMLSNSTAAVPLSLESSQSLAPLAVRRGLKAPKPLVLNGPKASEHDLYPGIPSPFLGSPSTYTPTFETSRHTVDMGLDLATMCRDLRSRCPPLRVESPGTPSLEDPSSMISNASVESGEGDDWTFAYPILEQFSAEPNFDVATACSKSNFDVEVPAIVNFTREPEPFSWTTERTLVEFSGPPLQSLPEVPAECQSTPADPKQKRRRTVIIETPRNSVIEGSRPTRITIDLSHLGDDASLSHASDQYIPFETPRHQSCSSDVFDESAPRPASSATMKVPVRGILKEKKSVRFSDVNQEQEPQESQIGVFGRKRSSTTPGCRPQSPHLKSAAIEKNANAKQNRSSFPKHPAVRSFVRSSTPSPLAGTPTPAPRTSQDRRSLQYALVPRSVEIAEVGRPRKLARTAAGSYLPPPAKNGNLKKGINDENAVRRESVAEKWQSLPRSGMAMPNKFRSMLTRFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFN7</accession>
    <name>A0A2R6NFN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFN7"/>
    <dbReference type="STRING" id="98765.A0A2R6NFN7"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="549" mass="59967" checksum="0232EE18DC807F6D" modified="2018-06-20" version="1">MGSVLSRAKLILGAVVLINRALDTLSKRLKTSPGLPVSNPSLPFWTIPKSTISSEGKDLPQDADIVIIGSGITGTSFAYHALKRDSSLRVVILEARDVCSGATGRNGGHINPPLFDGWKDLKERHGESDAKMLIRFRLAHVQDMKAVATEEDILKESQIRVTEHLEVHINREYFEEAREELEGWKTDMPDEAEAFTAFEESQVVENFNLAPGTAGCIWGPGGAMHPYRFVTCLLAKLLDRHSQNFYIATHTPCISITAPSRANPLYTVETPNGSILAPHIVHATNGWVSHLVEPMREKVVPVRGTMSAQRPGTSLSPATQDGLRSFVFHPGGLGYDYLTQLPSGEHELMFGGGWASAFDSAFADIGVSDDSSFSFSVASHLAGALPLYFGTGSWGKEKQPDTSDDDGGIKWGEGRTKAQWGGILGISADGLPWVGRLPRKISGRAEPPTTCTPRERSGSSGKTETETSTSDSVDDVVVRDRLRTASPGEWIAAGYTGEGMVHAWMSGKALACMVQDAEDEMKDWFPEMLRVTEDRWKKANLEEFISRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG44</accession>
    <name>A0A2R6NG44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001287">
        <property type="protein sequence ID" value="PSR71350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG44"/>
    <dbReference type="STRING" id="98765.A0A2R6NG44"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="50848" checksum="23EA6A23710063B4" modified="2018-06-20" version="1" fragment="single">MASVASAQPIALPSSSNNHDFVMGSGSHTGQNGSFNPASYTRRFMGSPISFRNGSFGSRFYPGVSPGQLLGPLDPNDFRFGKMSSSIESDRGSLLNALNVFERQDELCRDYQCCGVNLTDMHALVDHFEECHVVVVDPYAPQGSYTNPSAINGGQPPVSYFPDVQGAQMTPTYNQGSFDPDDMELDLENTSAPSSGSSSPPDTPISTPLSAYPSAYSQLAPQSAISAFDTTTVMNSRSGNTTMSVGFPPIRSSHPLATPRAEDAFNAYAGYSDYSSLMPGTVTSAGPMHSAEELHFSGSPYGARAGCLPPALLLNSSANTPDSTPDSSRVASPVSGSNNYPIQPAVASAQSSSQASTSSASQNGPQTPRASTTLSRPASSLLLSKPFKCPKPNCNKSYKQANGLKYHMTHGSCNFAPPKDLEHLQALLASKRSQKSEEGEPLSDAELREVEKEAERRLRPYACGVGDCQRRYKNMNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG73</accession>
    <name>A0A2R6NG73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG73"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="153" mass="16776" checksum="A56BBB5299703A67" modified="2018-06-20" version="1">MNPIDTSYFMIVADNGQYSISIQSSTELATEENSIKAAALLMHLVIFFGVRFLRNATQYLMSLLSPSVLGEATFWGLLTSMCCADDEFYTSFNGLSAIVCCIMLHPDILETLRQWAVHIISSNVRKEGSGSLRHTTRTAASSLPSTPLATEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGB1</accession>
    <name>A0A2R6NGB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGB1"/>
    <dbReference type="OrthoDB" id="2804775at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="254" mass="27847" checksum="9AF90593B6CD355F" modified="2018-06-20" version="1">MIRKLSSSSSLVDFDHFSEEIAFAERNPDEPEFGSAKKLPPVPILSYPSPLRSQSPSSCVSTDTHNDISGPSLKAKLSSTSLRNKPAKTVPRPWDSADFQPYSLMGAGGNLRYKWYAPTAPDLVYDRRPKPKPKPVAKTPSPSTVTEKSSKLSLKRVRLLGYRRSLTSSDFTNLGALAGMSDSASTTTLVSEGRKSNDYGSQGRKSRDIPPSDNDESDSRITTHHVVGNIWEEKDMSDVIPALRLLRVAGNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHL6</accession>
    <name>A0A2R6NHL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHL6"/>
    <dbReference type="STRING" id="98765.A0A2R6NHL6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015317748" evidence="1">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="13843" checksum="C3E6B095679E7FAF" modified="2018-06-20" version="1">MRGLLFSLVSLIIPLVYGQTIPGSYPHDYPGKPDGHFSPDWQSYYQVTDDMPNVTFPLGRNWAGNIPVNRPGHPNDTLFFWGVEKENGSLTASAGDRSNEPWGIWLNGGWDHLADYIWVDQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHM9</accession>
    <name>A0A2R6NHM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001234">
        <property type="protein sequence ID" value="PSR71895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHM9"/>
    <dbReference type="STRING" id="98765.A0A2R6NHM9"/>
    <dbReference type="OrthoDB" id="2756172at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="13660" checksum="41220D6B1BF38840" modified="2018-06-20" version="1">MEGFTETLAQELDPDWNIKVTLIEPGWFATAAVTGKATVLPAHPAYTKPGLPVVAVRSALENLNDPNNKFGNAEKAAHKFYELASLPDPPLRLILGQDAIEIIRSKMKSVASDIENFEAWSSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHT3</accession>
    <name>A0A2R6NHT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHT3"/>
    <dbReference type="OrthoDB" id="3001418at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="477" mass="53562" checksum="DCFD4043F20B47D0" modified="2018-06-20" version="1">MGTSTRRGDPEEEAPLLMSFTARSKSTATFGVEHLIGQTIMALRTAMLCGRMKPSVEARLLDIVSQVRSETPQLWPRYIIEELFDYQRNHFYAENIRLKSWDIILEILAKGGWAQVASVLRTWPSIEVQVFYRQLILCKLSGWAVKPLHPTAPSTRTSHATSMSQRQSLTTRSVALSQGLAEVFTASLKQDPALLHEMFTLDFFAVLHSSLIPIPWGGSDASLNMFFESLALCQLFDALPPETPATSIPSLLPVLLASFPMIECMTEFLRTGHSDNNKVMVDYILRSIKPYTYVYKHTTSQPSGLLDSTTTTIMHPTFPFLWFAMFMSYRHEEAGALFLAGGMSEIIQDIISNDFYTPLGGFLSPRQSKEHMYRRVVCYLLLYAIALHHEPDDDTSKLEIELEASLVGLRVADFTPSIPVPSTPELRVHSIDSPLEIPMSIVTEAVADFPKSRNTRQSNKHATKGVIAERKLTFVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHT4</accession>
    <name>A0A2R6NHT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHT4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5343" checksum="E9BF4FB3E63206D6" modified="2018-06-20" version="1">MPDIGKAVSGCNIASAKSAYNHRIPTGFVEHQKHADSGLNTESTHPKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIP6</accession>
    <name>A0A2R6NIP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIP6"/>
    <dbReference type="OrthoDB" id="3257643at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="157" mass="17720" checksum="7EA568E12CADAADC" modified="2018-06-20" version="1">MAAVPGAPQMKIRELEEENMHLSRQVKQLHRQLLETRSALRPDIDQRSATPPTFDDGMVECDSDVVKLRRTVEESDDLYMSISVPGRPDYYGLRADTSGLWGYLLRSLVPVSDAREPVIKHNVQSNDFIFGECLFCLRPSRCTCAQLAALYVLTFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIT6</accession>
    <name>A0A2R6NIT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v11868</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIT6"/>
    <dbReference type="STRING" id="98765.A0A2R6NIT6"/>
    <dbReference type="OrthoDB" id="2732867at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="45"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR72276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="137" mass="15381" checksum="4D17E99530DBF116" modified="2018-06-20" version="1">MARTKQTARKSTGGKAPRKQLASKAARKTAPAATGGVKKPHRFRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEAAEAYLVSLFEDTNLAAIHAKRVTIQPKDLALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJX9</accession>
    <name>A0A2R6NJX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001143">
        <property type="protein sequence ID" value="PSR72667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJX9"/>
    <dbReference type="STRING" id="98765.A0A2R6NJX9"/>
    <dbReference type="OrthoDB" id="2803256at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="233" mass="26304" checksum="B673917B7E926816" modified="2018-06-20" version="1">MFTSAIILNNWLVNPTGRANSFVPVDLLQEHMNFWVKNMYQAQGSAASWEWLETISPCINVLRDLATQMNNTLGSQQGNKHHAPDLSHDIKELMRSLRTHRVYQQERGRAIDDGSEVSDILVDGLHGLVGPLRDYNTAFDRLRVRRKVEPLVRKNSISESVSLRESDGLVMDLDTTSDSKDEEDETDVLDEDGGVVGLDGESGNEEEDIWDEYGYIEPVFSLDTAEDIGLDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK21</accession>
    <name>A0A2R6NK21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK21"/>
    <dbReference type="STRING" id="98765.A0A2R6NK21"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF361">
        <property type="entry name" value="TRANSCRIPTION FACTOR SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="298" mass="33288" checksum="942192F4F0EBF227" modified="2018-06-20" version="1">MSSSQLRNTRQRSQSQHLRTPPLSGSSGVDQSPDARDIAQYPTPPTPAYSLPPFSSITADLPIPFSPITWPTEHTDTRDRYLIAPATQRSDPDDEGLDCEALQAYVGFDEGPSSASDFVKKLYRILNDPTLAHIVTWGPRGDCLVVKDAHEFTNNILPGTFKHSNLASFVRQLNKYDFHKVKNEDDTESGERTYIFRHPDFYAGGWDALERIKRKVPVPKASSSATGDSSTSVCNTIDALQEKVDQTAWRQDELTAHIRNLETNYGSVMDSIIDIQGHMNQRDVLVQSLSQYLSSSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK90</accession>
    <name>A0A2R6NK90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v11350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001135">
        <property type="protein sequence ID" value="PSR72787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK90"/>
    <dbReference type="STRING" id="98765.A0A2R6NK90"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="650"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="789"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR72787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1040" mass="114340" checksum="04BD386355D8BAA7" modified="2018-06-20" version="1">MASDIVDSSNSLNRPPAAEEKSEESQNSPTNKSATPAPPKSTIWDKLPPWVSANLRSNRARKMWLRCWIASWAAFIIILPNKSLSTLGNAAFFSLLASFMIPANMPVQLFLFALSTMVVGMCLGWGLGAAAMRAALASRNQLVLKQSLLREQQSVAGLSNPDALFQADIFAGKFLDTRSTVVFGCFLGLGSFFFALIRAYAPKLIIMSVFGTVTLDIFCSYGPLFPFGEYTIVNSLLISVASYIAIGIVLITLVFPETVNHAALIGTSDLIGKLKHMVDIQQRVLDASQEDLVTGQPLANKLQAARAGILVQIQQVIASTKFIGGEFSWGKWNGDDITALHEPLMSVVSRTSALHSFAKLVGHPRFTGDSASEQPSEPSDASSSSVSNVFSGDTYLLRQLRERNNATEAQHSVRVADLLPVIEDATSDLRNACSAGLASVKTLLDGINSRRYARKGATESQQQLADLDQAIERLNICLAEFKEHKRLILVEPFQSLLQSADTTKGPMPLRSLYVAYVFAANLVVLARAILKLMETVQATAAKRKKNRLWMPGGLRALAKAIVSRGETSDQAAGEDNVPQAEEEVKKEECAYKLDPDSRPPTNALQRAASTIHSLYKWCKTPEALFTAKYVILTIVLWIPAICHRSAHFIYAEKGLWALIMAQTTLNIFASDQIFNYVARILGTFFGAVFGLLAWYIGSAKSNGSPYGSAAVMAVFLVPLTFIRLFSPPQYLPGVLLFVVTYALIMGYSWIDGHLPVVGNPGIGWPIAWKRFVQVMIGCAASFIFMMLPPKSGRKAVRLRNSATITSLSFLYRDIVAAWISSEETSLTEKRISPAHSVEWIPGFRDRLLAVAAQLQAVKVQTMIAKWEGSIRGAWPGDEYMKMANVQTEMISSLALLGGALSQVDSHMRLSFLQYTRVVNPNFIADVMATFSLVSQALRTGEPFPQALRQNLFDRLHYHGNVGHRSLATGGDVTHEALHRDHLNAIMQYEYMFYATAVSAVFQMLDGLNELREIATRLCGEVPLQGFARWKDEYDRAHVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKK5</accession>
    <name>A0A2R6NKK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CcmS related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKK5"/>
    <dbReference type="STRING" id="98765.A0A2R6NKK5"/>
    <dbReference type="OrthoDB" id="3171339at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058258">
        <property type="entry name" value="CcmS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26617">
        <property type="entry name" value="CcmS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CcmS related" evidence="2">
        <location>
            <begin position="830"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1013" mass="107565" checksum="1AAA311440DCCE1A" modified="2018-06-20" version="1">MAKISKVKKKVDKAKTDYHNDTHSAAVPAASLGPTQSFSPEAKPIRLVPRLDTINLEFPQVTSPEALDHGHAAGAGEWDAGQGTWEEPPGVAADADGAWGGSDSGSKSGTAASVGSPVFATWGNGAHVAQDGWGGGGGVSPSQLASALSQAVPTQHGGPASGNLAAELAARKGMLKKPPPTVPPNSGAPHQSHAAPPPPAKHVAFGATHYSSLPQAQGAPAQNTTSPATRNRAMHAKSQSQSSPWGPPQATPPGFGGYSLPQQSHNNWGLSGSYPPSAGQNRGPVAYPGTAQQAARNPASQAGPNVMAKWAHETKSGGLPRVATTVAANVPSAPPQPNGTSFRSPYAEALAQRQMMMQLQNAARLGLAQHANPQSQPASTMQNRQTNAAERTGLYQSWQSWGKIPERGAVGIQSQAPPQIQPANSWGQEWSGAGDRAGGGGRWPGTTGDTGGSDAWGASNNVDSWGHHGDDGRNEDDDDGEEEEEEEDDWGNAGHAGGGGWDTGRSQKASKGGGSRGNPRGGGGWGDSRGGDRGGSGWGASGGDGWGASGGGDGWGASGGGDGWGASGETGGRGSTGGYKSHENGRSSRKPTADSGWGTSKIADHGWGSHSKDHAGDGRRGHPERKPTADSGWGHSVPAGGDDWGKPSGGGWGKPENGKREEKTKHRGLLDRFGRSHRQNKSDSEWEVINEEDEEEYEDEDEDEDDDEEEEYDDLDDMYTEAGGDENEARRNAHISPRISYQYQSPDDRRPLALHPVSAPAQTTSFLSPAYGHRRTQSTPAMPAMPLPEASMTMNFAADRMATNFDLVPNRGRPGENRIVFSQNAALLYAKRALYSTRTRPAKERIHWMFNPNRDPRVQSLIRWVLGTADTLAIVGLQKFLETRQRGALFTNADFRVPSAAGAPIQPAFDWINLRQLSPTLDRKLQKSVICYNPATHVVVFVFLLSKSGNSMAIWRKKVAIPEQVRLAYKDAITLAVEGLPKDLVVYVDELPPPPEEPPKKKRSWWRRLFRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLH3</accession>
    <name>A0A2R6NLH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001107">
        <property type="protein sequence ID" value="PSR73098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLH3"/>
    <dbReference type="STRING" id="98765.A0A2R6NLH3"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="188"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="551"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="675" mass="79636" checksum="58D9BC01BDBC0B80" modified="2018-06-20" version="1">MAGRYSRSVSPRPRDEHRRRSRSRERNPREADRDKTSSRYDGDSEYRKRRRSVSRGDEKEGESSRRRRDRSRDEDRKKRKRDKSEERKARKAEKKRMKEEEEARQVAELSVYSATDNPFHDVNLGQQFRWHKKNEKERKQGLSLAESQRRDELRRQEAKEELERLNKRRAEREADQRLREEEEMRMQRLAESAQMADWLSKEEGFQLDQERTRAAIRIKEKRAKAIDFLALNLRYVNPISEDNAEVDDEELEIDLDEPYNILDSLSPAQVEELHGDIERYLTLEQSDVNIEFWTLRNPLTPAQHMMVVVKDQLERFGANERLGAEAAAAVEGDITALLRGKSYDHLVVLQKQIQAKLVSGEPIDVEYWEGLLKKLLVWKAKAKLKNLHEVVVRNRLEQLRKRQRDEALQAQEELLAGVAKSAARGERPNAVSEPEEQGIGSAEEREPYDRSMSPALLDIRKLPFEERQIDIVTELEDLRALMAQRRLVAGSRFVPKTAQPVVESQEPEILASNADLASEALYRAEAERELDEEEELFNVEENITNPTTYNWEDKYRPRKPRYFNRVHTGYEWNKYNQTHYDTDNPPPKVVQGYKFNIFYPDLIDKSKAPTYKIVKEPGNDETVLLHFSAGPPYEDIAFRIVNREWEFSHKRGFRSSFDRGCLSLWFNFRRNFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLW5</accession>
    <name>A0A2R6NLW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001095">
        <property type="protein sequence ID" value="PSR73250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLW5"/>
    <dbReference type="STRING" id="98765.A0A2R6NLW5"/>
    <dbReference type="OrthoDB" id="2802364at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="262" mass="28771" checksum="AF1E213826DD3083" modified="2018-06-20" version="1">MPALRDTHTHAQFPTHILVILDTPALPTTNNDGLDATPAIHPILIPVNAELFADTFEYDLAKRMKRQVTTPPVPQWNESTNRLEITLRVTTLQVSHPPSIPLLLLFGLGEQFWQPTDSPPPSPSSEVSSTSSRSSKSQTLVADDGSVCVGLLSTYLLPVDVIEEFPAPAAMAQTMAQICTNEEFEHYLTFNRGLWQNVLVLSPKDQAIMGIVGTAWNVTREAQRIRKKMRSTKKSPPLYRAPSHSGDCEDSPPRAAVGALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM12</accession>
    <name>A0A2R6NM12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001116">
        <property type="protein sequence ID" value="PSR73052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM12"/>
    <dbReference type="STRING" id="98765.A0A2R6NM12"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="240"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="787"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="924" mass="105164" checksum="F545B96A653CBD53" modified="2018-06-20" version="1">MDLQNSKSSNASAITVQAAAGVPVDGNTLDFEALSLSTTFSGINSDVSQAVTPNSHNFPLPPAIETTRPRSATAAQGRATVHPELPDARAAHFRARASDATMAFNKFILYENKLRFYIVASNTSESRHKIVKIDRTSQDELDVVEDDATYSGKQMSAMLKMLEDGNKGCGGLGKARMFFGIAGFIRFTAGWYMIVITKRSIVALLGGHYIYHCEETEILPVSSTHRIEKPTDEQRLMNIFKQVDLSKNFYFSYTYDLTSSLQHNLTRPMAFSRMFSDRFAWNHNMMTRAFEHRESSPVKSQWLLPLVHGHVDQAKLTVLGRVIFITIIARRSRHHAGARYLKRGVNDEGNVANEVETEQIVSETLTTSFYYPASPASNPGGKPRRPSPNYTSYVQYRGSIPIYWTQETTSMVPRPPIEISVMDPFYTAASRHFDDLLSRYGGPLMILNLIKKREPQPRESKLLEEYTTCVKYLNQFLPPNRKMEYRAWDMSRAYKEKTQDVIGYLEDIAEESIQMTGFFHSGPEPYAHWLKSEADAWNAGTGEAVPVPWRDTMYLQNGICRTNCVDCLDRTNAAQFVFGKRALGHQLYALGVVDTPNLAFDSDAVNMLTEMYHDHGDTLAMQYTGSALVNRVETYRRMPHWNSHSRDIIENFRRFYTNSLLDADKQAAINLFLGIQNDRAITQPVQRGGYRDWYQAQNLQPAYELEECERGIQEFVSDRGDFWIEYYRPLLFTSLGKHFVYSMNSTLKLPGKSARDINNSPFMPRYIVPLHPPRLMDGVRRWIRAGSPSKRNSVRAESRHEAGLKSSKSDQRPDKTSTEYIASALLDPVVPLEEEHEYKDYIDQCQDMLNAPPDYAERKDQKVYINAVALSALDDDDPWAVPDKELELFGVYMKKGSPYTAESAGSRENLPVTFNYEKWITCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMK4</accession>
    <name>A0A2R6NMK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMK4"/>
    <dbReference type="OrthoDB" id="3356019at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="13981" checksum="42A79B95A1E117F5" modified="2018-06-20" version="1">MDRARRREEVNRAYDVQVRAGTEGALRYTSIGIGLAILGHYTWPLFRVADVSLVTIWGLVSYAERALQSLEINQRQTESVIRKEARIELSRRGIVPTETAIAQWKEARAREQGENAPSRTQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMU3</accession>
    <name>A0A2R6NMU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001067">
        <property type="protein sequence ID" value="PSR73718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMU3"/>
    <dbReference type="STRING" id="98765.A0A2R6NMU3"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="692"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114936" checksum="05CCA96328413725" modified="2018-06-20" version="1">MDLPPFGDSPGQRRRAINLGGSTSQTTQSALLQEARARRQQRNDLKRKQDSATKIQSWWRGRQQARFVREQMRALFQDNATNITGLRCVVLIGSDDLVLAKWSSAMLADGGALLLQATSDPTWMTLLRRVSVLLLQSVSVHPLSNPALLNVQVLSLMLSQQCPAGFTLVLLHYLLNNGYYRLLGRAVSQIPPSSKSTPILPLLVTLLAAPFTSIDTSSEHYLSSLEDFIIYILTIPILPNRLPLNSLTYLAPRIPLSNIHIVSAVRISTSISSTQSIPESHIHLLANLCAFAPPRYNALTVEALTAYLRLTTEILNTLPTHALEPPKTDTSVQQSWGDVYDSEDDSPTQVEVVSSFAPKPYLPELDNKTLTRLQTLPSPNHLNSLLAACHKHRSQQTRSALFGWCQALCTVWPSRKDKVVSSVVAWSGGGLVRELYRNYVRSSPLGQDSNPTALTDPAHASHWPPLLFLVDLYNQALLTMGDDEFFSSSSVTISAAALSSSSSASSAVAARNPLTLDELTSFSRQLLNIAFTLYWKEDPTNVQNSSVPGILNLKWEAVRERLTKLLQAIHARDSRQPFMPPDHWLVTSQLDIGPFVEAAVFEEREISGATEGTRQTRAMSQRQIALISPRLGVLNNIPFAIPFDVRVSIFRNFVQNDMATRGLELGRERYRNMTRVTVRRGSIAQDGFDRLDGVDLKGPIAITFIDQFGQEEAGIDGGGVFKEFLTSLCMEVFDSDRGLWLATKKNELYPNPHSYATEPHSLAWYRFIGRILGKALYEGILVDVAFAGFFLAKWLGKQSFLDDLASLDPELYQGLVFLKHYTGNPEELSLNFAVAMEEFGVTRNIPLMPDGEQIPVTRENRLQYIYLVSHYRLNKQIKKQSDAFFEGLSEMIDPKWLRMFNQQELQILLGGVNSPIDLDDLRSHTQYGGLYGDHEPTIQIFWKVVQSFNQDQRRGLLRFATSCSRPPLLGFKELVPNFAIRDSGADQARLPTASTCVNLLKLPRYRSEQVLREKLLQAIQSNAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN31</accession>
    <name>A0A2R6NN31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN31"/>
    <dbReference type="OrthoDB" id="3173670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="16189" checksum="F711684BE87B89DD" modified="2018-06-20" version="1">MDSEWTVPQVGSVDDFELCRAVKEKGRPTGRYELLSTTDIVKQSLVNWESLFVQFKDANGEWQLSLNPSRTSLAIHGLQTLLVHYDRNTYLSEIIRMNTSAAGKLLPVQVSLPVLVEDDEEEVEQATRKGKRKAGPEDDLSSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNG0</accession>
    <name>A0A2R6NNG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10342</name>
        <name evidence="3" type="ORF">PHLCEN_2v10343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001061">
        <property type="protein sequence ID" value="PSR73826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02001060">
        <property type="protein sequence ID" value="PSR73832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNG0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="7967" checksum="D49A3BE61E960E57" modified="2018-06-20" version="1">MTRPGAGSNQELGAPLYAALLYPTLGARVIRTLPYPILAGLAFLYLPVGFAPALRPDQPQSTVSSKSRRIERTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNI7</accession>
    <name>A0A2R6NNI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNI7"/>
    <dbReference type="STRING" id="98765.A0A2R6NNI7"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="10347" checksum="8BA1B55EDDB0D664" modified="2018-06-20" version="1">MTLVSFALGNIIGTEIFQPGDAPAYIPGKIAILVLLSVQLVISYLLRWINLRLNKQKKAQLEAEQARRGWTDADVQKERERHAFLDLTDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP04</accession>
    <name>A0A2R6NP04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-structural maintenance of chromosomes element 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v10122</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP04"/>
    <dbReference type="STRING" id="98765.A0A2R6NP04"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="77"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR74166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="164" mass="18961" checksum="7926DC4B0FA958DA" modified="2018-06-20" version="1">MLELQPYLRSTYPDEILECTICMEIVTRGIACYTSRCKTRMHNHCYDNYRRRNQNCPACNKNWSTEANAKKVFLIGEGAFKDGQDKGKRRTRRVAEGSDEEESQMDMDEDASQQTQTQQPTQTQGRSKKGKKKATQDDDMNVDEDEDAEDATPPPRTQKRKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP68</accession>
    <name>A0A2R6NP68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP68"/>
    <dbReference type="STRING" id="98765.A0A2R6NP68"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17103" checksum="FFD2B59F2B84F377" modified="2018-06-20" version="1">MEHSPAPSKWSTQSLFAGIGDDIHAALLEFCGTTVFLTLAFGGVQASAAEAGSVAEGATSVMRIMYIAVSFGLALLVSAWLFFRVTGGLFNPNVSLSLLLVGVIGPVRFVLYCIAQLLGGIAAAALILGLTPGPLMSKYVSYCSTQAEVADEPPFKYLLSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPK6</accession>
    <name>A0A2R6NPK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPK6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="148" mass="16129" checksum="EF15B25119EB0D50" modified="2018-06-20" version="1">MRQKRCHVCGPLYFVTPDLSDSYFSGIVTTARLLKDPTELTDASLSEDVPLLTQGRKAGAVLYLCLHLLARKTLTLVTIWEEKCVVEVVLYPVGGVATLLAEGKTINEAPARPGHPIHVFGAPITSKIIHPLIAATGVDDRTVETRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPR9</accession>
    <name>A0A2R6NPR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPR9"/>
    <dbReference type="STRING" id="98765.A0A2R6NPR9"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="27112" checksum="A0EC9669FDCE5DB2" modified="2018-06-20" version="1">MAPSQTQDVDKLTLTVFREVWNEFYAWKHSACEAAIQKLAATDEATRLAKDDYAGLFDSAPARTSETPSDFVVYDFCSKSTSNTSTISINASSITPASQYESCAPIPRNVLHGDDPNEMAFVPYADDTNFDEVDYAMEYKNLSWQVDNDPDSSNTVVTKDPATPLPSVDVLQRADIAKGLVAVQTTYRMILISLTLLKVPDVGKAANVQLLGVKGSTYVYLAGDVLASCKLFSARMCLYNAIKQRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ32</accession>
    <name>A0A2R6NQ32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase</fullName>
            <ecNumber evidence="1">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ32"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ32"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="319" mass="35963" checksum="88D1019F38BE5C5F" modified="2018-06-20" version="1">MFHTDGTIEVRLSASGYLQGGFWEPAQEGYGTAIRDTTMGSLHDHVINFKVDLDVAGMENSLLYTHTAQEEVTHPWFDDDWGKTVIQQKITRDYIENENDALLKLPVNFQGGYSFVNKAKTNRWDIPRGYAIHPGYSPVHNTVVGSKRLLNNANWARYNLAVSRRKDTEPSSSSMWNMNLPGGPMVDFHNFFDGENITQEDLVAWVNVGMHHLPQAEDAPNTRTNLATSSFFLTPLNYFDSDVSMDSLNAILLHPPEPHSQYTFDDYGVKPAQCIPEAIPPFEYSGLTAFGLDGRPAPEVSLEELRKAAELYHRIKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ60</accession>
    <name>A0A2R6NQ60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000965">
        <property type="protein sequence ID" value="PSR74678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ60"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ60"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="9497" checksum="161732CEF07E3866" modified="2018-06-20" version="1">MTHVTVDLANPFTAGLKITGIKSSIKSMSLGLGTINTSTKFSSNGKSTTMSPDLDMNMNFDPVTLFTLTRALAVKAGESMAQLDSIVVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRQ5</accession>
    <name>A0A2R6NRQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000891">
        <property type="protein sequence ID" value="PSR75484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRQ5"/>
    <dbReference type="OrthoDB" id="2690041at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="11099" checksum="27BEA0E4FC35BDB4" modified="2018-06-20" version="1">MAVPIRDKIGIIRAICVKASEDKQYVDDFVYEIARKEKDKAICSKLDDLTLAEDKWERADLFIQLLVAATEKIADYYDKTGDTDAYVISMCQCVVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRX6</accession>
    <name>A0A2R6NRX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000889">
        <property type="protein sequence ID" value="PSR75496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRX6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRX6"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="116" mass="13419" checksum="E913BE80DC89457A" modified="2018-06-20" version="1">MPQGCRNAPATHQRRMFNILREHIRLICHVYLDDIVIWSQTLDEHRKNVATILACLRQNRLYCSPKKTNLFCLSINLLGHYISANKIEANNKKVEKILDWPVPHSASDVRAFLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS42</accession>
    <name>A0A2R6NS42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS42"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9096" checksum="2A342DEEFD227780" modified="2018-06-20" version="1">MSRFMLNLQDVSSPSSMNTAQLSGLEFAISSHSSRMVGNLGQPLAHFVEPETNVDDTSGYVLHCRIPSSPRLSSVIGHFEELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS77</accession>
    <name>A0A2R6NS77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS77"/>
    <dbReference type="STRING" id="98765.A0A2R6NS77"/>
    <dbReference type="OrthoDB" id="3219582at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="552" mass="60590" checksum="5235DF03C67DE458" modified="2018-06-20" version="1">MLQVPRTIEVKFTDETVTVFFNSLALVVFTVFQAITFAICFYRLVRVMVNQKRIDDTVNGNDQEAHLFNGMGWITAGIKLGMIETVVGFAPAVFGEAITRRVLRFLGRAMLIIGVIKGVDTVEDFSMFNTRERPIPRRSALLALIANPRNSSFRQIGGYDFETSMAPPAAVARSRPISEMPPSPPLLTRPPSAYKPSTPVLTVDTRNASPAKNSRVIVRYGHGRAPTLDLRRISDLSIPSPLTLYDPKSVPGSLFDMDEEKSSYFPGSMSTPNLLDASSTALVNSYSPVFPIPTPEHGRRRPSTRRTYSEGVRDFKRNARRSSSVLPRPSFGSYSGASENMDVLHALAMQFPGLPPRMPASSSVQTSVLDTTIQDDTDIWSPGLSRSTSGRSLSSSSGLVRRSSSAKRKPVPGYLNFENDRLSRLARPGSVTSKTTTLVQEIPIPPLPSTLPTATNSITFTTRSSMSHTRPRRYTESEVVTNKRSSKLEFPWVEGAGDIAAEGQAELDAAWMKIGFSRIKSVGSVPRRSTPTPSHSTFSRDSIAAEWHNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTI0</accession>
    <name>A0A2R6NTI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000847">
        <property type="protein sequence ID" value="PSR76377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTI0"/>
    <dbReference type="STRING" id="98765.A0A2R6NTI0"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="487"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="645" mass="71043" checksum="7171849BF4A388A5" modified="2018-06-20" version="1">MDNDALSPSQQEALSQLQALTNGGDADVARSVLESVDWDVQRAANIVFESAPTAPLSIPSIPGASIPGATYTSTHTEAFEIDDSEQDGLLSGRPSGREFPRISPSSSILSLLLRPLRLIIALLAVPYTILRVVLRTLHIPLPLPPVPLSFSITGLGLNFGLSPRPSLGPAPVRDAKTASERWIRALEEETGCVSISRAQMAGGGEASGVASSSAPGLSRRAGDESPSSSRVLPEFFIGSYESFVKACAKETEPKIGCAVLVSDEHDDVAEFKRSTLTDPGFVRLLQENDILIWGGDIRDRDAWGAAQKLQATTYPFVAFVALQPRRGSSAIAQNKSILTILSRHQGPSIPTSSGPTSPSTLTTHIADHLLPRVTPVLAQLRSSATERDAALAVATRARERERALRAEQDRAFAESARRDKERIERKMQEEREGKEEERRRSMEEERAKEEQRKREEQRKVWEEKRMAWRRWGRRAFVPREPRPSEQGRGRTVRIGVRMPDGRRAVRFFGQMDSLTAVYAFVDTLFIPEGNAFSSDLDPLTAPDGASSSADESGLMHAISTMTEGRTEEWWGFKLVTTYPRKEVQWEPERKVGEVEGLKSGGQLVVELVDGEYGSVKGKERERRSLESRVVSAKGSESDEYETESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTI8</accession>
    <name>A0A2R6NTI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000848">
        <property type="protein sequence ID" value="PSR76360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTI8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9785" checksum="B669270BBD07D22D" modified="2018-06-20" version="1">MPPTHIGYKPLLTDPCSESSPEEALSDQPYSERRCPWYRRTIVLWAVIAMQSAIVLALVAHYEAGSQSSCARETLLYCKARCAPYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTJ7</accession>
    <name>A0A2R6NTJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000847">
        <property type="protein sequence ID" value="PSR76397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTJ7"/>
    <dbReference type="STRING" id="98765.A0A2R6NTJ7"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR76397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="296" mass="31907" checksum="695B71B9A482D8BF" modified="2018-06-20" version="1">MPIPPAVLAPGVLTPTDVEHVLPPQPTIPAGPLSTVPVSSVQVAPLATVVESAKRLAAWTAVDKHVLPEHKVIGIGSGSTVPFVVERIVAQGPEVNKDRVFIPTGFQSKELIVEAHLRLGDVDQYPTIDVTIDGADEVDKDLNCIKGGGACHLREKVLAEAADTWIIVADYRKNSDVLGKNWKQGVPVEVAPFAYVKVLQNLRTLGSEKASLRMAKMKAGPIVSDNGNFVIDAPFPEEQMKDPFTLLGRIKMLTGVVEVGLFCHMAKAVYFGNQDGSVTAKWHDGHAEHYDNSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUL5</accession>
    <name>A0A2R6NUL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000818">
        <property type="protein sequence ID" value="PSR77008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUL5"/>
    <dbReference type="STRING" id="98765.A0A2R6NUL5"/>
    <dbReference type="OrthoDB" id="3260094at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="188" mass="20922" checksum="D7E35264574BBD5D" modified="2018-06-20" version="1">MLLSDSGAQSLHGRGTRVWKVVRVKDGEAVGDPVVLKDSWVDLDRPREGAILQEVCGMAASEPADKTLSDALLTVECYGDVVIDGDGDQCIDRTTRMNLSDLPTHGSDTDTAVTKLLLHRHHKVHHRVVFKEICQTIQQLASFHDKFRVLGQTSIKLDNLALIQLVGYIPCYRNSRRFWEATLYPGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV77</accession>
    <name>A0A2R6NV77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000795">
        <property type="protein sequence ID" value="PSR77402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV77"/>
    <dbReference type="STRING" id="98765.A0A2R6NV77"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="12464" checksum="4A6675006737F7E7" modified="2018-06-20" version="1">MPQVVRTPDALPTFPVFSQAMISRGYVYVSGNIGCKEDLKTLVEGGVQSQARAALENVSKVLQAAGSGLEHIVKANVYLTNMANFGAMNEIYEQTCIGVASLPLGADFEIECVAEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV93</accession>
    <name>A0A2R6NV93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV93"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11733" checksum="F1363F3D30790938" modified="2018-06-20" version="1">MPDNVHTSVPKACNHLSLKATGKRDLQDVEQIAMCRKREKRSRNEHETYLRSFCSQRLGMHQCEVRAGFTPQPIECVEHLRVPGLRARIKTVQEDRELHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW39</accession>
    <name>A0A2R6NW39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000760">
        <property type="protein sequence ID" value="PSR78068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW39"/>
    <dbReference type="STRING" id="98765.A0A2R6NW39"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="926"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="571"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR78068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="955" mass="107935" checksum="7EA934F54C02537F" modified="2018-06-20" version="1">MDYDRYDAFLHHVFKQTQGDAWFRPNEDTLSAGVALRVNDGNGSGLPEFRVFPYENLALEPFEAAIARLNPAVAVKVRSAAVHAALAEVSQDDNSIYVDVNTRIQILETMMDLPTADKEQSAAFIRDERVLIVWSDSIDTIIPTCHDFEERLIKLLWRSRPNAAGAATSSSSHPTSLAGSQSGHGSLTNLNARLSQSQYAGPGSRYSSTLQPPGTPRGVHGMSMEDLHGDLEKADDMVDEKSLKTKTKRTWYGRKKTVVVADLEEGMPEPRPAMFYAPFYNGFAFGLSLFFIGNGVSVLLIEWQLDQNFTRFALCAVIPLLFAVSLFFCLQIVQNLCMAVGPIAQYRENSKYYSANKPRPNKIVDNNLPHITIQMPVYKESLENVLAPSIESLKKAMQTYARQGGTSTIFINDDGLRILSREDRDTRIAYYANHGIGWVARPKHDNAPDGFKRAGRFKKASNMNYGLALSLKAEKHLEALQANQEKERSSRENSREIREDLRYGMQYQDRDGDNQEIVEVGREEGGAIDGGEWEDLEEKALMLAIDEVYETSQRRWRPWAANGRACRVGEIILIVDSDTIVPEDCLRDAAREMAECPTVGIIQHESDVMQVAHHYFENGIAYFTRRINKCISFTCANGEVAPFVGHNAFLRWRAIQDAAFIDKADGLEKIWSESNVSEDFDMALRLQLAGYIIRWATYSQGSFKEGVSLTVDDELNRWQKYAYGCSELLFNPIAQWWKKGPIAHQIHKFLWSNAPMHYKISMMAYMFSYYGIAGSITIALVNYILLGWEFPVDGFYLHSFEIWLATTVVFFGSGNLGFTLLEYRLGERGLFWGLLTNIMWIPFFFFFFGGLSIPVSQAILAHLFSYNITWGATKKEVERSNFFKEIPKIFKRFWFPLAASVIILAGIVIVATPLVPLQWRIGGDGWAVIFPLALVASCHILFPIVLNPWLMVFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW79</accession>
    <name>A0A2R6NW79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v7498</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW79"/>
    <dbReference type="STRING" id="98765.A0A2R6NW79"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR78166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="44409" checksum="7E80C57A3EEF9E05" modified="2018-06-20" version="1">MSSQKDYSKSQHSYPSATKQEYQEDVRHIEEIPASDKDGTPSPMDPYGGYPSDRSYGRWAKLRSFREPVLPAGEHITKYPNRWSRIREILREPAAEFFGVMILIIFGTGVVAQVVTSANTGVAPGPKGEYLSINLGWAAGTALGVWVSGGISGGHINPAVTLAMAVFRDFPWRKVPIYMFAQLMGGICGGGIVYANYIHAIDIVEGGRDIRTLSTAGIFSTYAFLGTAVLLIIVCAITDRNNGPPPTGLVPLCLFFTILAIGACLGMQTGYAINPARDLGPRILTAMVGYGGQGGITTAVLYATMKSETDRQLGSDNTNRSDEERKGLLSEEGEYSLSEEVPEDVSRSRLYCLAAVLILLMLGAVFAPPLLRTSSTRPTADFDNQKLRSNGTHEFRKTALIVSIDGLRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWE6</accession>
    <name>A0A2R6NWE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWE6"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10550" checksum="7355F82C15ED372C" modified="2018-06-20" version="1">MSVEPSDTTQLPVTETVEVLKSCHKCGKTGLQRLKSHLHTMHAEKVNVTFADGTRRTVFRESDDPTEGSSFRCPRCQRIYYNTMQLQASIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWM0</accession>
    <name>A0A2R6NWM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000744">
        <property type="protein sequence ID" value="PSR78404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWM0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="181" mass="21114" checksum="09A706FA58FA1939" modified="2018-06-20" version="1">MAATVRPTLIEMIRDHNPAIPLPRHCFVYGLHWSELFLHIFLHFPVYIPSDEADPGHWEFCQIVVAEHRITLAELPIKYDFWHYQGNMVLERWRLIIALVTIRRHMSLLRRIMYPSDAISSSQGVACNSIINRKIDDRDDVIACRVVFAQKVHMRFSPATKPLLILKKVSWQMNLGSNSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWY6</accession>
    <name>A0A2R6NWY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000728">
        <property type="protein sequence ID" value="PSR78716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWY6"/>
    <dbReference type="STRING" id="98765.A0A2R6NWY6"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR78716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="493" mass="54449" checksum="D1EA520C200F19AC" modified="2018-06-20" version="1">MAFESLRQRYEAAGQAHLFQFWPELSENERTQLQAQLEALDIERVNRIYKNAVSSEKEAAEHAGKDIIEPLPEDAADSVIGDTEKEKEWRRIGLKAIANGEVGVLLMAGGQGTRLGSSAPKGCYDIGLPSHKCLFQYQAERIARLQVIAAQDEGKPADSVVIPWYVMTSGPTRPETEAFFKKNSYFGLDSANVIFFEQGTLPCLTTDGKVLLETPSRVAVAPDGNGGLYAALRQPISPSDKSRTVLSDLAHRKIRYVHGYCVDNCLVRVADPVFLGYCIHKQADCAAKVVPKAYATESVGVVARRGDKFSVVEYSEISREQAERRDPKSGELAFRAGNIANHFYTTDFLNEVESFEEGLAFHIARKKIAHVDLESGKLVKPTKPNGMKFEMFVFDVFPFTKRFAVLEVARNEEFSPLKNAPGTGSDDPDTSRRDLLAQQQRFLERAGAKIAEGAEIEISPLVSYAGEGLESLKGKIFTRSGMVESVEELDALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX04</accession>
    <name>A0A2R6NX04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX04"/>
    <dbReference type="STRING" id="98765.A0A2R6NX04"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="447" mass="49904" checksum="43DF1ACEABDFD267" modified="2018-06-20" version="1">MSNKMPDALNIVFISLSVSGQLNIHLASIEHMLTLGPSESPPLNIHLISFDPAEKRARTLAASASPRHSFTFHGLGELTLFTETSQNGTIDRHRPAELFRKDGLKPYTYLAELFGYNPDHYIRAYERILEIFREIKPKINVAAVDTTMPMAMDACTTAGIHWGVLCPNSGIELFKHQQPRLEGFWKHPAIRALEVRRSKAGIQGRVFNKSFQRLPFFICSSVMEMEFPHIPSPNVVFPGPILVPVPPLSSATYPDLTAFFDRKRTVIINLGSNFWYSHEDVESVADAILDAQQRCQEKGSFQVLWKLNGKKAFEIMLEKKFGKQSDTVRIDEWIEPDTLAVLQHPNVVAFVNHGGASNAGVPQILLPQWLDLYEYAVRTEWLGHGIYANKGHPAEIVADQLADAFLRVLSDDEGKILKAKSLEIAEACRRGGGVQTVARTLLAAATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX20</accession>
    <name>A0A2R6NX20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000716">
        <property type="protein sequence ID" value="PSR78911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX20"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="618" mass="66932" checksum="998E5818F498C84B" modified="2018-06-20" version="1">MAAQTVSGYRDADVDKSTVMKFMREHIEVARKEARLCQEDLTRLQRERASKMRLIKEAEDCIITLKSEVELIDLHILRAEEMESRAIQAVNDIRTTPSDSAQSTLVSTSPSPSSHSNAQYSPCYISALQTKPNITTSAGTSGLFQHLGSHDVAHPPIIPNYFPVRQTMDDSEYYPSLRPQRSPMSYYYPNYQHISLGGSRLMPTVTSSSVIHPSYRSTASAPSITNRMEVPVTRTTFCPPDVRTTLISNTGMDTPNNSVSVATAPHGPSSVPSGDFCVNSASSMLRKPSPYAFSGVVAPPLELSPIMEYHGPVSRAPFSEDGSRQIIKQPDPSSSLHPEKIPVSEADTGLPATLRDASLAYLTSLARLEAMGASFAENRSVTLASRNNKSINPKPLGQNNMQAEPPSSGKLSGCHVPKGLRALSPLKAELKKLDQLVLAGTTRAATLLPERASKPWSELHPAASQRLRDLHGVCAPLRTFPGRACAPTSDATEPNSEGGNGRATTMHSAAYSCELFAELPLNEDGKGKEKENRTDTGVYHPCNEKFDAGLDGETHAESIRAVAAPTPATSEGGDDTGFERELGLDMTGLSRPSSSFSFCSDLDERCSVFSDNTNDEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXI8</accession>
    <name>A0A2R6NXI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXI8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7072" checksum="B0B97811A202104F" modified="2018-06-20" version="1">MSSVRGGDTATDAPKRIRTAMREGVKTVARQSLGTWKRVEKKGSNNAERNEGIASRVDVTVEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXT0</accession>
    <name>A0A2R6NXT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXT0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6850" checksum="50CBD955A33D61C3" modified="2018-06-20" version="1">MYIVWKGMAMHTMSTWFKAAENLWWMLDSNSVFQSCEGEGNEPLQYIRREHWYVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYP7</accession>
    <name>A0A2R6NYP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v6727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000653">
        <property type="protein sequence ID" value="PSR80470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYP7"/>
    <dbReference type="STRING" id="98765.A0A2R6NYP7"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR80470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="260" mass="28419" checksum="346F422EECD9EC57" modified="2018-06-20" version="1">MSKTFNRLLRSTTTACKYEAYVCTVVEHLRPYKANPFDEIAVEEAVRLREKLKDEVKSIKVVTIGPTKAAETLRTALAMGADSGIHVEIPDSAPPPEPLGVAKTLRALIEKQKEGVDLVILGKQAIDDDAGQTGQMLAGLLNWPQATFASKVVVDTAKKEVTITREIDGGLQELRCRLPLIITTDLRLNEPRYASLPNIMKAKKKPIEKIKPSDLGIDLTPRIETIKVAEPPQRVGGGKVENVDELIAKLKEAGITPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYQ7</accession>
    <name>A0A2R6NYQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000652">
        <property type="protein sequence ID" value="PSR80503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYQ7"/>
    <dbReference type="OrthoDB" id="2553859at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10905" checksum="4827863DACD57459" modified="2018-06-20" version="1">MSNMSRGITVTYNLNPPAETPSQGLSASQTLHFPVQTPEDDVKKYYDGLRKAIAQAKDVMGTDLTAWRDAVGLREQLKEARVPKRLDEDEEEEDGGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ18</accession>
    <name>A0A2R6NZ18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000629">
        <property type="protein sequence ID" value="PSR81016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ18"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="21912" checksum="E16BE5915907ECB3" modified="2018-06-20" version="1">MLVDLHYSPMQATEGHLWGTHVSEGVFMTMFGPFHRLGEQTPFAYIKEVICLIASNMPRDPTSPPIDVHVTPIDPFVTSPSKLILRDLYTFGSPRFALEDFVDVFMLVMDTHHGYSWRIVSEGDPVTLVPPVHLIDPKFIHLDKAWQVSENAEFQELPSERNSHPRPPIPVINMSYHTPWAYFNALYRAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ37</accession>
    <name>A0A2R6NZ37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000629">
        <property type="protein sequence ID" value="PSR81035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ37"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ37"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR81035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="303" mass="32508" checksum="8F970CF945F0C2E3" modified="2018-06-20" version="1">MFSGQNWTRLIRFVAAETAQIHIGEPIDPELDVGLAFHKEQAIKAYEIFGSALDPAAQVTKNVLTVKQLLPPLSREQIGVVRCLGLNYADHAAEANMAKPQFPILFYKPPTALIGPEAPITIPRVTQPASKHLPDYEVELTIVIGKAAKDVSEADALDYVLAYTGANDMSFRYHQLAVSQWGFSKSFDNCTPIGPCLVAATAIPDPQKLPLKCTVNGKVQQDGNTADQIFSVRQTIAFLSQGTTLLPGSVIMTGTPKGVGFVKKPPLYLTNGDDVTVWVDGGIGTLVNPVVEEGASAAVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZM2</accession>
    <name>A0A2R6NZM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000616">
        <property type="protein sequence ID" value="PSR81504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZM2"/>
    <dbReference type="STRING" id="98765.A0A2R6NZM2"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="14615" checksum="A6BCB14DDC9AC25A" modified="2018-06-20" version="1">MPPTKTFRPLPNVPSAKIFKPFSSPSTSTSTSSSGTSGSRVTVAAIPVAREALKPTSPASPETPVRPLSGLKPARKTHTSGEVPSVTPVTQSTLPPISTPPTPNKPPPARKDPMTSLFMPKHRAYSQLPTQSTGIRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1E8</accession>
    <name>A0A2R6P1E8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000562">
        <property type="protein sequence ID" value="PSR83327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1E8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="438"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="617"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="895" mass="100225" checksum="3B06F7026B027F7B" modified="2018-06-20" version="1">MIFYLSLTLEVVILMIASFLFPGLVEPALRTLGPCIGSGQGSPVAALFNSTKTFGFLSDVDVLVARAPSMERGVIDVGIYGPQCFVPTNCTAPPYIEEHVATSVSRSSIETSRCTILFTFPTIVHCSPALSVNISAPTFARSSAIVPGPSSTTTRLSTDTQANLSEASLGVVALSLNALPTLPRPSVKQATSSHPERLTVAVVLMVGFILLVPQVAIHIQLTTVILRVKIYKKFKDFVGLTQLENVVVHQACEQELLYFRYRRINQYAYSADTSIAFLWQAIQERVNSFNNLSDSYEAVKTSEMVLINEVASSNAYTDDLKSEATLRISDIHSQIYHERERHVQELAHSDAILSSLQQHIDLRDDDLDRLLNAYNIIRASEASLTDEVADLNTELFAVKQAHDVEILELKSRIEKEHEEHRTAFTNFMETITALGRDIRILESDLNIALRSAQDAQERYTVAERQLEFSQLEYKCLLEDLPRQHAIAEAKLSAVQADHDELAEKYEEQASRLKLTQVALGETSEESARKHAAFRAYQAAHKVEAAYAEGLEETIDEQRIKIVDLEESYKTLETRYDEQTYCLRLVQASLRDTTEVISRDNATIGAYRISRKIEADYAEDLEETIERQKLVIADLKNTGEEQKCKISDVERSHDELQIQCDLLKEMYANAIAQTLIPDPQLAEKDAEIQRLQDLVLREQQEKEAIRTAADNDAVVTRNALLRKLSEAYDHGDRLQEDLKRKDAAHQVKYEDLDSRFKLAQAALEQSTEVPKSSTRARRQSAPPLSQTLLTKRLPIEQFLRENEALKEKNSQLEKELTDIRSKFLCEASTIKQDDLTSVSPSSISSCPDTPTLVHSPSGFSDSSSILATPQMDSYELDTSTCVAVTWQLCSSEPIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1S0</accession>
    <name>A0A2R6P1S0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000554">
        <property type="protein sequence ID" value="PSR83710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1S0"/>
    <dbReference type="OrthoDB" id="2651057at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="221" mass="23777" checksum="CACF8B5382751D6F" modified="2018-06-20" version="1">MAADLLSIAFSHNKKYKIPDFVMQKEEEEPKEVEDTAAESERRSSGKTANPDGNPSKQQCVNTDTCTREARDIGTTVTIKPVTDATASATIEALESAPSTSVQKAGLENFFKKTVKPGAALTMTKGSGEESWWRKHCHAVPLEKDMDTAWKSSEGKTARGAAGNHKPGFCSDGAPVKLKSGQVPHWLQPQGVFTADTQFPHPPVLQGCAGPLAESDCGHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P237</accession>
    <name>A0A2R6P237_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000546">
        <property type="protein sequence ID" value="PSR83996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P237"/>
    <dbReference type="STRING" id="98765.A0A2R6P237"/>
    <dbReference type="OrthoDB" id="4743193at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="356"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="683" mass="77542" checksum="D82168A36733DEE7" modified="2018-06-20" version="1">MSLLDGIQQVLIQHKSSLSSVVISVLSDPSNSAWMAHDLLNSIDQILSAFGQHSAARSWISKIEQQGFTKELKVLTKKEHGWHFSARQASAEQIEEFHLEEMADRMQRLAPRLWSLLTALFTPSEYRKRAHNDEVLEDEEEDQYWAELDGLEDENLAVPSRDGYTERGQRADASRVERRRKMIYMVRKVVVLSVMMLTVNQKCNALASVIGIFCHANNTPEKVVEVLQRLGVSISIDAVQDAIISLSHQSHRAIRALGQTLTAAYAYDNFDIDLKTSIPTIEKSMEPSLKHLTSGLLFPLPEGTTKDDLKCSQLLWERSRLNDELPDSRPGLAPLPDWKNLFRIHPQYHLPDENGMTCRQRWIAWKFLHDIVNHGPEYFRQFQAELQDPEAIEQVPLTKTRVIPARAMDICNSTVSGNLGAIANLIMQGGIGVPDETNETNLQSLEEFVVLFHGDLGSGERITHGQIRRAIEGAPLERYQFVVYVFGLFHLKMASADALWRIFIRLSAARLDSTSVMQHIALLRSRQTGKFISNPGFRPMHQAITHDGRCRRLNCWAVEATNRNPAHTDLDQFAASKPSFTILLELANHLALHYVASQHHLEKLRSMPDNLRDEQYANGLVINQYYLLYEELSYAMNVGDIGRVEACFAPWTLIFKATGKHKYAAELIKHVTNVHFSYPEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P277</accession>
    <name>A0A2R6P277_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P277"/>
    <dbReference type="STRING" id="98765.A0A2R6P277"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR84210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17112" checksum="27B31D478049A3A9" modified="2018-06-20" version="1">MASPTSQQPQQINVTDLDLPQLVDVKKQLEEELSHLSNSFTQLKQAQAKFKACVENVTEIKPSNQGKTILVPLTNSLYVPGKLCDVENVIVDVGTGYYVKKTRTQASKHYEAKVDYIKSNLETLQETIQKKQDNLNFLVNVMQSKLQTETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8G1</accession>
    <name>A0A2R6P8G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000521">
        <property type="protein sequence ID" value="PSR86940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8G1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR86940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8459" checksum="2AA87E220B2205EE" modified="2018-06-20" version="1">MYRLDKIASLVDVIITYSTTSFSALRVFAIWDRNVPITLLVLVLNLVPVVTNIVPFALPPSMRPPVSVSRESITGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8V0</accession>
    <name>A0A2R6P8V0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000515">
        <property type="protein sequence ID" value="PSR87270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8V0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9633" checksum="FF6D5B3CCBE9E8C2" modified="2018-06-20" version="1">MPKIYPSRVVLAKHEPLGLLERITISNKFKEIGKPQRIPKPVHQSVIPHPFDPELSQEAQDEIDRKVICKELVDLDISFDYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8X0</accession>
    <name>A0A2R6P8X0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8X0"/>
    <dbReference type="OrthoDB" id="2533496at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="11360" checksum="88BB8ABDC11D2BAD" modified="2018-06-20" version="1">MSEPAASVEINDALFCQQHLKEVCADCSFDGREENDAFFGFDPIDRESLEVPTSSPNKEGAYQCKKHSSTTCNQCFGWKKQLTRARAAAKKAGKKAGPTSNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC48</accession>
    <name>A0A2R6PC48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v4986</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC48"/>
    <dbReference type="STRING" id="98765.A0A2R6PC48"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR88837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="53149" checksum="9C1DFBF6BCC6FA0B" modified="2018-06-20" version="1">MFSALYLLALPFALFAYLWTMRRKRNILLPPSPPSEPILGHLRTFPRIDQDQAFYELSKVYGDVMHFNVLGKSVIILSSTEAATDLLDKRSANYSDRPAFPAFELLGWGRTLVFTPYGSSFHVQRKLLTQPFTRQGCAVFQPIQLQQAHMLLQNLVHSPEDYESHIRRYTAAIIMQITYGHRVQSDDDRYVKLAEQVNDTILAMGRATILDLLPFLKHLPPWFPGAWFIRYARDTQPMRDEMENEPFEEVRRQMTWGTILIFIFAILLHPEAQKRAQREIEEVIGSSRLPDFDDRDSLPYLECLLQESRRWHPTISLGVPHRSMADDVYRGMFIPKGATIIANARALSLDENVYPNPHLFWPERFLPENGQPHPTSAMFGFGRRVCAGKNLADASVWIVAATILASFDITMVKDEHGKDLPPKVEFTRGLTSVVSEEGEQLPCTAILALNLDLQIAHANTTWSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC63</accession>
    <name>A0A2R6PC63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC63"/>
    <dbReference type="STRING" id="98765.A0A2R6PC63"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25498" checksum="EC9CF9BAE80D85B9" modified="2018-06-20" version="1">MVSKRLTAFWAFVDLWLLAAGVLSLVMSLVWRAPNLMLNFTLSNADLLAGTILGIFLLVTFAISIFAVVQKNHVTLGLVILNWTLIADAIAVLVIGSMIWFFSLQQRNNYFKIFQAQSDSTRLAIQDKFQCCGYFLQNASDVVYGGFCANQTFVNTLVNPNNTDQFRCVGPITAFTDFTLNNVFTYIYGYMAILILLFLASLCIIHQRLEAERFKKIDSKRGGKGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJ84</accession>
    <name>A0A2R6PJ84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal membrane protein PMP47B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v4762</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJ84"/>
    <dbReference type="STRING" id="98765.A0A2R6PJ84"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR92232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23432" checksum="9C576CE46EE7B2CF" modified="2018-06-20" version="1">MGEQSTYQAVVDIIQQEGILGLYSGLRSSLLGISVTNGIYYYFYERSRGAILKSRPGSKGLSTIESILAGLIAGSATTIISNPIWVVQTTQAVHTMKQPASDPTRPAVKKSGITETIQHILRKDGISAFWRGIGPALVLVLNPVLQYTVFEQLKNMLITRRTAKLKAAGAVMTAAVLLSDIDYFFLGALSKLGMYFSTTSVRLSLMTIYAQLLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVG7</accession>
    <name>A0A2R6PVG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVG7"/>
    <dbReference type="OrthoDB" id="3260379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="34724" checksum="8B2CDFF1B770DDF2" modified="2018-06-20" version="1">MGKRPKVPAALHSELTEYSSLLRALRTTNALDLASQLTTSAPTPRSKDRDVDVAGDLDVEDENEKNIGLRQSQQDDGPSESERPLTGTSISSLQGDRLPPAASKAKVKPRTRDIRTKGRDTWTRWPLLAGDVHVPEWNLEDEVKLLAVKTLQHHPLLEAARRTHHDDEDEREVLQPTLGELEGLESEEEDELAEDESSLNAAGTSSAGNAPNLSPTSRPHSTVDVSSRTSSSRHSSPSSPPAVHAIAAHSPVDAPDETVDSLLNPSLHDITICTARHLSQILALLAAYAPSSEKSMQNRVRPIGWESVLDIAGVHGLVDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZI4</accession>
    <name>A0A2R6PZI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v4232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZI4"/>
    <dbReference type="STRING" id="98765.A0A2R6PZI4"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="12">
        <location>
            <begin position="323"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR98912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="542" mass="60511" checksum="CB1BAEE941172182" modified="2018-06-20" version="1">MSGSSSSGPSSPTVSRPISSTPTSPAIHALSLDDPTDEARKEAAKVKAEANKAFLSHRFNEAADLYSKAIDLNPKDATLWCNRAYTRIKLEEHGYGLSDASTAIELDPKYAKAYYRRATCYLQTLKYKQAIGDFRKLLALEPQNQLVRTQLDSTQKILRKTEFEKAIELEEEKSAVLRCLEIINEGGCDLDKTYDGPKLAVGEDGKYQINVEFIKGMIEWFKAGKTLPRRYVWEIVLGAHAHFAQEQSLVNLDLEDGMTCDVIGDVHGQFYDMLHLYSLTGEPSDKHCLLMNGDLVDRGSWSIEVILTALAYKWLYPKRMYINRGNHETKEMNRTYGFEGEAKHKHGDQTYKLFAHIFTTMPLATLICPTKPPSPPSPNAAILSPDGKKRYFVVHGGLFSKDGVTLDDIRKIDRIGHQPGTEGLMCELLWTDPQELPGRGPSKRGVGIAFGPDVTRRWCEANGVTGIIRSHEVRQDGYAIEHDGLCTTVFSAPNYVDQAGNKGAFIRIDDRGTQRYTQFEAKPHPPMKPMAYVSGGLQSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5C8</accession>
    <name>A0A2R6Q5C8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000399">
        <property type="protein sequence ID" value="PSS02214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5C8"/>
    <dbReference type="STRING" id="98765.A0A2R6Q5C8"/>
    <dbReference type="OrthoDB" id="5588148at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="556" mass="60778" checksum="FF09515CEC24F8FD" modified="2018-06-20" version="1">MAPIRNSRTSKKSPQAPGPTKQRKGAARARPGAATSRTTPNTVITSKAITGTSGNSIQLHQTSNSEPQTSDSGATATTAIAGPSVPPIDFIAPQAGTITDGSGWNPDLAQLQAKLTNLKATGKQTIAAITAVTLDQPITAEDIMLVAAVSHAVSSSVLGSEDESWSSDSEYVPSPTSVPHIPWCACLHTPSGLSNVMPMLIDSGSTTVLICEDVATSLNLRHCPLQNLFHYKGAFGEDIRTSTVCGKLRVSTTNSSWSSITVTAIIVPKLCSPVISGLPFHAVNKLVIYSELQTMIVRSTRRDLLKPAPIQVRNHRTEQQQQKEEHVEQQQRDEMAQEGALLKKMFLDLQGRDMVRELKLRSGKHKPCIVTGLTHDKIVAMIQQQANELAIADLLSHKNTTMRLHFADLSPNNIPHISKLPTNVYHHFHLKDPNLVIARCQYKCPKKYREVWKTLLTQHLEAGCLRPSSSPYASPAFLIAKNDKTALPCWVNDYRKLNANTIPDVHPLLSIAEIFSDCGKGKFFAKINMTNSFFQTCVHPDDIHLMAVTTPFGLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB45</accession>
    <name>A0A2R6QB45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3933</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000379">
        <property type="protein sequence ID" value="PSS05346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB45"/>
    <dbReference type="STRING" id="98765.A0A2R6QB45"/>
    <dbReference type="OrthoDB" id="2796710at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS05346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="14225" checksum="6A6FA4EC16BAA48E" modified="2018-06-20" version="1">MPWLLLRSAVGKLSENCWKAVGKLLRSKGNVAEELKVIVAMMERQSGRKVQTIRSDNGTEFVNGVVEAFCCRNGIQQQTTVPYMPEQNGIAERAIAVYFGMVRSMIHSAKMDLHYWGEAFMYAVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBC9</accession>
    <name>A0A2R6QBC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBC9"/>
    <dbReference type="STRING" id="98765.A0A2R6QBC9"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117205" checksum="AC143DE1E196F85C" modified="2018-06-20" version="1">MVVSPGEDKFNDLMQLQKTKGSWDGGDQGLLNEWRGSNWNRLSFIYNTTPTAAYTYAPAYERFGTRISAVHFIGPNKPWKSLQWRAPGTKSTETIVDDGTKRVYDYDSLVDRWYDVYDRHYRQDTPAPRREFEVQRYTSAWDEGSSLGAETSSTYNGEPPAPRSALGLQDLRRMAIEGLGALAVGTISGPAEGEYRSMPLAGRIDLMRTQKHEEQPSQHYEGQGSSSFYHGGDDGSPATPRPSHIQIPSQEQQGYFRMETLPTPAPYEVPSAPYLHGHSLPPTQTNTPYYDPNSGQSYHQQPQMPWYRPDSSESDTSPASRAPHHQSQEQHQQSEEHHQWQSGSRAEHQQYGGNSRYYPGHHPGRDSGFQTPMPGRPEQHVYVHSHDAHQGLHHEHGQSQHSQGQAHDHQHHHGTHQVHHHEHGQSQQYQGQVHDQHNHGSHHHHHHHHEPPARPASPPKVSWNPALEPPPKEAPPVSAFPENTYYPNVWDQTGSQQHDATHQSYRSPDRSERSDTFFHPPPPSNIPEQLVREGQYANVIGSTPHQSPESVSSPPAPDRKKVHAVFPWEEKPRHSPRRVFPRTESPPPPANYIESERTSSPVSTPPPPTERRAPPLIQSPTSPTSSPWGLGFSNAWDTVPSIQRYASKLAGSPKIFPHQFMSQPPPEPREGWRKLEKERERDWQEHQDASSMDGDDEGESDEESEHSESSAKSKTSTGSHRKSRALSGKSKKKYCARGVQAVPETKEESIQVNVMVRDGVMHTLREASVATDSHSTTAPCPCCGRSCVPEECASSQASPQQRTGVGLGIRRWPESTGLLPSAVPRDFKAELEQMAGTPIATKNVRSGLPFPGSASPTGLRSPATLGSPRTYSPPKATSPPLAALPPPKIASPRAISPLQAPSPTKAMSPKNTSPRQIISPPPLATHDVHSPHHAPSPRRTSTSSMTGPSRTGSPVIGTGARMQQSSTPSPKLTRLSSLSSPFSPTLQRSTSNESAVTPSPSTTHDSLVTPENTPIGARKSGRVWDPARGVDVFKRGSEEVLARFLRMGSFDDDEGKRQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBF4</accession>
    <name>A0A2R6QBF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBF4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="12719" checksum="14230ABA0F1E4D58" modified="2018-06-20" version="1">MGWKRHFKYDHKDIALNECKLDFADLRAYSKQSGASADFTTKAPALGSSRDYDKLDSLWEKFQSLAEEAIMDEVDTEDIIADEMIADEAAVADARPARYIPLAALMTPFFACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBH4</accession>
    <name>A0A2R6QBH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000370">
        <property type="protein sequence ID" value="PSS05470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBH4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9408" checksum="5152F2E3103D14A0" modified="2018-06-20" version="1" fragment="single">CGNVSYWTIKDGWTSKDRIGQGSTRTGAETLGTVLSYVVVRQIPGLNRRLAWTWALACSNVKDTNVSWEFERVREMQNLEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QES7</accession>
    <name>A0A2R6QES7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6QES7"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="204"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="7">
        <location>
            <begin position="439"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1381"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS06635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1586" mass="180798" checksum="CBF257B8DD2EBE98" modified="2018-06-20" version="1">MLFKMLGIERDWDNMNDCLDEKIPHPRQIFVTQSGVLAEKVNEYYTKLSESHAAAKRTAEASAKMASKKQDHQNSGLVDRDEEEFWRGTLPKRYSDLREEHFPLFITFDHLCRLLEADLRDSNKFQLLSPALGDTCTDQGTLANDYMSQRRDCFVSYDIFLKSYWPHFSQALKKNLDPALIFAEFMGIIKGSEQTLQSINGFMDRNAYVNLSHRQQGTFASRRDVVYTLFESYLKLKSERRHWDAADRTHAILLGLKESGVPGQKMDFVYVDEAQDNMLIDALILRTICRRPDGLFWAGDTAQTISVGSSFRFNDLKAFLYRLETTVNTGASIGAPHSFQLTANYRSHGGIVSCAHSVVQLITKFWPHSIDILAEEKGIIDGLKPIFLSGWDQDTVQYEQFLFGSSSSQLEFGAQQCILVRDDVAREKLRAQVGDIGLVLTLYESKGLEFNDVLLYNFFEDSKVDVSQWRVILNALPEEKQIKCPQFDDTRHNGVCRELKFLYVAITRARKNLWLADCSSRAEPIRTLWTSTGLVQHCTASDTQPRIAVSSKPEEWAKTARDLFDNRRYSQAARCYERALLGRERDVAYAYYLREQARETFSDQHTTYNRRSIAFLTAAQAFMRSAAVATIRTENIAYYRNAAECFVEAGDDAKAAEAYGHAEEFTRSAQLYRKAGWFDHAVEVVQSHRSSIAEADAERIIDVAKLHYFKENKLERATNLFPSLDDALQFMDNYDFNVARVNLLESTGRIAEAAELHLNEGRTVEAIRLFIQDSADPDSQRRAEECLLQGLWKQLSFGVHIKPDADISNTPLGELMELSSDMQNNSRFLAPQAQDEISMFQAIATRQLLRLRELAEKFHNVYKDPAATLLCLDHAFDSAPKMNALTHTELTSFLRMFLIYTTELQRILSDIDPSHNPLLQRLFGYHPLAQSENTIAIQSGTFLSSFISENIRKASDHMDPLTLSIWEFTSLFKNAISNRLKERVKTENTACSQAHSLSPCPAFAIFGSCNSNTCYRIHLNGRDLDSDWHHTRIRIIFQQILIYQAVSGIEDRFTVQMQHRFWLEALFNALHPVHHKLGSLSALDLRRFPEAQKGLQIAKHWICDSFYTLSPWSDDSKLFMTIVAETAILGLYFDKTSAQHYINHAPCVASFKERQMLLLRGPADDPRYVVHDLLDSIDGSEKFAISAGVLFIQMVSEKRLTFGIHVMCQLIERLCASFAFAYRFQRFGSLHDLTLMRSWILRLCGDYDAAAAQSTQLLSLFLKPMANILEEVFSGSQGWFAVEQALRASSLYDKRHFDESIQLKEESKLTDTPRYIRGTRTVIFKDGRDIPDLVDRRSTLEAFVPEPDLLPETQVIVQEDMDEPPSVDEEDEGINRNVDAEAAASSVDAGRVNQPPAPPTESEIVAASQIAAFYRRTTSRRKGLPKKGPSEARVRWFLTCRENSQDMGVKYRVLYLGPLPHALACLEGINIHVTALKKKAMSRLVSAQHADLEVVQEQVDRAISITKKTVGLRKLLDPKSQFHRTQSISQLEVNIEQIVKLMSTLHEGVLREWEWDFKIAIKGILQQRKPPAKTPKPELVIDIEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIU1</accession>
    <name>A0A2R6QIU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000338">
        <property type="protein sequence ID" value="PSS08884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIU1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS08884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="5973" checksum="343F084CF564F253" modified="2018-06-20" version="1" fragment="single">IDREALNLHKAFPTVVGNCITILSPTTAKDGVLLMTTRFKYRAIAYLWGNYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIU4</accession>
    <name>A0A2R6QIU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v3410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000328">
        <property type="protein sequence ID" value="PSS08920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIU4"/>
    <dbReference type="STRING" id="98765.A0A2R6QIU4"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS08920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="228" mass="25849" checksum="BBFD1D5F83B82D37" modified="2018-06-20" version="1">MIEQASQSLAASSLPGQIQYIQSAAEQLPFLENGSVDLIASAQAAHWFDWSKLWPEAARVLRKDGSLAVWGYSEFRLTRYPSATPLINAYAQGADPKDSLGPHWERPGRTIVDEHLVAIPDPKDVISGAFRDFERVYFTGEHYPTLTSPRPVILRKTMTWDNLLSYLRTYSSLHTYHEKYPEDLQNPEGDIAVRFLNRLKTITTDKEGAHADEIDVEWPLALLLARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIZ3</accession>
    <name>A0A2R6QIZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v3404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000328">
        <property type="protein sequence ID" value="PSS08914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIZ3"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015321664" evidence="7">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS08914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="27370" checksum="14820E8D541E9015" modified="2018-06-20" version="1">MSCIYLALGAVLLSATAVFAGDKVSLSNDLTQQCKFMVDGNAFNLCPLLKRKSLWIVDSEQDTPPSITTTRYTLSFNGPIEKDTTLPDDMQVATSRFPKHESEPPRVTQTIPIAGELSPEHCTHIIKSGEYYPGLNVTAEMTSPWGSEEPMLSVRFNGGYYVDKPMGTSLLFQCDPSADESYVKKHPSLLKFRVGEGVLIRWASEDLELENGEEDLMVNGANASYGDDEEQIPLKPSPRKGHLTGYGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUI4</accession>
    <name>A0A2R6QUI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000311">
        <property type="protein sequence ID" value="PSS15397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUI4"/>
    <dbReference type="STRING" id="98765.A0A2R6QUI4"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="270"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS15397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118125" checksum="60D77BFBBA4FDF1D" modified="2018-06-20" version="1">MVIDRSRGQGGTSRSIPPGSLRKPVRHKQEVKTDSEDDIDITTPYTVSVRLPSSKGSSAVISPALKAKGTPKKTAALARASTMPVVASHASQSRLASPPLERSISAANLLSPLSSMALNELPTPSSVQLSSSGFAVIAHNALKQQLMDNYGLSWGTQYEIARGITNGWWAWEDVTGPKMSELKDTNQRSAPKVADVLGRPEYAAGYNYPLWAELDREQAAIIENNSRGLGLQGEWMGESKWYGGRIQQIVHLVKVSNSDKEKSVRYELKLGRMQMGRSHRFARFLGSRRILQIKLPKDYSTDWAMMKKYFLQKFVLCGRVYVPFSVKDGKLYSMEINEDYERAVQVGEGDHYRLSLDEFVRWHNPMDLNAKQKVSKWVSRFDLGLSTSVPAIKFEPENITRIGDEYAPFEGNDAPAHAIFTDGCGFMNGSALMAIGRQLGYSERPTAVQGRIFGSKGVWILHPDDRLPDAPPRIWIRASQQKIKLLDTLNEATLRQVHPAHVIFDLLAPSRVSIPARLSRLTIINLAHNKIPKQVLVSLMESGLRAEVAALTQWSGPAAMPLLWSAVNKVSGVSSLRLQRYAAGVQRALGLVRRENDPDDDESESEEDPTTSPDCLIDGKPPSIGETVLEKLQSGFSPLEDHTLFEDIKQVVKNTIESSVKDYHIVVQQSAEAYIVPDPLGVLEEGQIHFKSSQNLEDPLESLHPNNITGEVLIYRNPARVPSDVQKVIAVSHPALAEYVDVIVLPIKGARSLASLLAGGDVAVCVWDQTLVQSFVQPPVTEEPLNFLDRNFEPMEKVLQVASVLQTIKDLDPTEADVSLRSQLLIGLFTTILDSRKTGLLVREEIFRADRKSFSFAVPSCLAGSSTKENQHNRSKTKRYVTEPFILDELLEAGGLIGDDLLREYDSLGKTLRTGASDRHLRQPYEDVTASSSILKEEVQSVEAFVNEIYQKWGSIWSSRDKARGRDKDSERKRVKEVAACFKQDPTGCETLRLLGRLDAIKASYAYSLSPKFAFNCSFQTLCSIKADASGSVAFSRQFSETMTIPASAVRILSQRLSGPQDTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R0W7</accession>
    <name>A0A2R6R0W7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000287">
        <property type="protein sequence ID" value="PSS18886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R0W7"/>
    <dbReference type="OrthoDB" id="5083627at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="524" mass="58371" checksum="796E081AF3A41323" modified="2018-06-20" version="1">MSTDLASYLKGMHSQSVTCNWDVAVTYDQTKINALLADRHAQPGSGMITEIDIRQRVEDRYGEYYQNYQFNLGPPLIQFQSRTSTPTCSLRTQIVSGSIWSSEINDPDTKEDEKQLDPNTYWITISSIPLSALDGNADYVGGGDDTITFPPNDESDRYIVVDIPLVDEEELAVSVDYLDGYDPPYAMKREALVTALKLFFKKETNAFAYTLASINNHKPSSGTLDLVPQAFRFVTYKVSDELSFLTLLVQTKGSSSPGDTKDVQSEWVSNWTIDAKVPPVPSNQSASIIINNSFFLQSFVKPALRSQTTSMTDITINGDIGGIGLQCKWPKQTREKKDYSKGYGDVTTWPQDWKWSELHIPAVEYDPNNGSPLMLTFSHSNGFDKPATLHIYWQYKYKSTWNGVQIKKVWSHTDGPGSWEPKAKECDGSFNTTYTLDKTISLTDLSDEDLSINVDARADEWKPDAVPDAGNGFWGDISAAFGGTAHVGDIPSFVWDTAIGGIGFKFSFGTLRFFSVTNILRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7A1</accession>
    <name>A0A2R6R7A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v3014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7A1"/>
    <dbReference type="STRING" id="98765.A0A2R6R7A1"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="278"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="487"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS22648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="733" mass="81011" checksum="D98225C0E0FBA33C" modified="2018-06-20" version="1">MAPPHQFQSKGSDAVRRRLSSVVSSKRPNVVGYANLTPMWAGIAGAVVNNNTGFEVAISIHDSVYNTDFASTVVAYDPTEPDAQAENIEKHVTDTLRNFATEHLCKFLGAGVTLSLLKEAPNLCTQLWMKLDIVPIVFNIKPFHTDSITRPNIKHRISSTTGSYVPSGAETPTVYVDSNQLHDSSKLSSGVGQKLPIPRTVDEQADSAARKCIMYFGPGNNPRLSIAARNQVAVDAGGKIHLIDDLDEFRKTVGSGTWNAVNKLADELREKKIKMGFFSSTPQGGGVALMRHALIRFFNILDVDCAWYVPNPSPSVFRTTKNNHNILQGVADPSLRLTKEQKDNFDAWILKNGLRWTQEGGPLAPGGCDIAFIDDPQMPGLIPLIKKVRPDLPIIYRSHIEIRSDLVHIKGSPQEEVWQYLWNNIQHADLFISHPVNKFVPSDVPASKLTLLGAATDWLDGLNKELAPWDTQFYMGEFRSLCAKEKMNELEWPQRDYIVQIARFDPSKGIPNVVDSYAKFRVLLEGTVSSVAEVPQLLICGHGAVDDPDASIIYDQISTLIHTKYPQYAKDIITMRCPPSDQLLNVLMANSKFALQLSTREGFEVKVSEALHASKPVIASRTGGIPLQIVHGKSGFLCDVGDNDAVAKHMFDLYTDDDLYDEMSEYAKTHVSDEVSTVGNAAAWMYLAVMYASRGVRLQPNGAWLNDLMRAETGEAYKADEPRLPRAGLNVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6REN3</accession>
    <name>A0A2R6REN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000262">
        <property type="protein sequence ID" value="PSS28486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6REN3"/>
    <dbReference type="STRING" id="98765.A0A2R6REN3"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS28486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="23368" checksum="242340EBA08362EF" modified="2018-06-20" version="1">MLAMATLNLAGYTKLGEEAWIDKRDGPGGPMGWLTTECVGQSCVMGYYGYIVANFMADGLLIWRTCIIWDSYLIVLLPCLMYFASTALSIVSVYQIAKPGDNIWSDTTISFGIPYMALSISLNIVLTLLIVARLMYISNTVRTVLGAEHSGTYTFVATAMVESAAPYSITSIFFIILYGRHSNIQNLVLPVLAQIMDDSTILLFPKLEAQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHY2</accession>
    <name>A0A2R6RHY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHY2"/>
    <dbReference type="STRING" id="98765.A0A2R6RHY2"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="412"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS29634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="511" mass="56179" checksum="C3584D50C5692288" modified="2018-06-20" version="1">MSKRSGGDLQAASSSDLRESKKPYGTTDKIITDEMGEFEDGWEDEFEEEDVIDGQAEDGMDVDDEVLPAIEESEEQPPAPQAFIPGVHQIGPDEILEADESVYLMRHSMNVNWPCLSFDVLRDNLGNERQRYPATAYIVGGTQADVAKNNEIFVYKMSSLHKTQKNTDDSDSDNDDDDDALDEDPVLEYRSIPHLGGVNRVRAQPLPVSSPLPPASQPYYVASWSETGKVHIWDVRPLIEALDVPGYSPDPSRTHTPAFTINSHGRAEGFAMDWASSGEANPSALRLLTGDVHSKIYLTTTTPSGFNALSQPFTSHTSSIEDLQWSPSEATVFASCSADQSVQIWDVRSKGRKSVAGIDNAHGSDVNVISWNRGTSYLLLSGGDEGAIKVWDLRNVKKRGTAALDPTPVAAFNWHREPITSIEWHPTEDSSFAASSADDQVTLWDLSVEQDDEQSGAMNDTPEQGRDVPPQLLFVHQGQKNVKEVHWHPQIPGAVISTAEDGFNVFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIK5</accession>
    <name>A0A2R6RIK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v2660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000250">
        <property type="protein sequence ID" value="PSS29845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIK5"/>
    <dbReference type="STRING" id="98765.A0A2R6RIK5"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="96"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS29845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="489" mass="53853" checksum="2CF044A1DC9F9A1F" modified="2018-06-20" version="1">MTSSRNLAHGRTDSLDQGASATPTLREEPVDVPLKEKSPKHPDPEAQPDDEIEHAEETEQVEGRTAGEQDVLIVDWEGPDDPQNPKNWTFKQKWAATAIVSAFTFISPVSSSMIAPASDALAAQFGITSSVLIALTTSIFVLAYAFGPLFLGPLSEIYGRSRVLQAANLWYLAWNLGCGFTQNKGQLIAFRFLAGLGGSAPLAIGGGVLGDCWRTEERGKAVALYSLAPLLGPVVGPVAGAWIAERSTWRWVFWSTSIVDAFIQVLGVFFLQETFAPLLLERKAARMRKEMESDPEKAPAREIRTRFDHSDRHWQQIFAKALVRPFKLFWFEPIAQLLGAYMAFVYGLLYLFLTTIPGIFEGVYGERVGIAGLHYFALGVGLTGASQINARFMDRIYMYYTKKNGGKGRPEYRLPSMVPGTIFLPMGLFITGWTAQARTHWIAPDIGIALVGAGTILNFQSIQTYVIDTFTLHAASGMSRILGPHPLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPH3</accession>
    <name>A0A2R6RPH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000214">
        <property type="protein sequence ID" value="PSS31921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPH3"/>
    <dbReference type="STRING" id="98765.A0A2R6RPH3"/>
    <dbReference type="OrthoDB" id="2731295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="265" mass="29474" checksum="23DB4397AA8E47F6" modified="2018-06-20" version="1">MALAAGIKNAIRTGGADLRELHVFADNQTALRNIVEPGCYSGQMFTLSVIKDLRKFLCESPEHSITLHWCPAHVGVPQNEFVDQLAKSGLKRRSPDYRSFAFAAQMSTANMYQAWRAAPGNMGKNWLCPAGGFPLSHTVKSPLIANFGKLAASITARITRVVTGHLPIGEFRQKFNFDGPKKCLCGQPLETRNHMLFDCPIWKMREPDFTKEWLTTTATPKQFIRAVANFLSAHPLAGSFEMADAYKASEEENQTLHWISVGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQB2</accession>
    <name>A0A2R6RQB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000179">
        <property type="protein sequence ID" value="PSS32223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQB2"/>
    <dbReference type="STRING" id="98765.A0A2R6RQB2"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="35901" checksum="2A5A1F45084326DB" modified="2018-06-20" version="1">MPSAKFSVRISRIAPSAILRYGKYRSYSVASSTTSADGSGSSNPIPMNGRRPHKEGTIQDLFTALTHEGPPLPQRFSDLKKELFTEQLVESWRDVLKELETTTEEVAAKGTDNIPQVDYTSITNGLSEQQVKNVKKAGAIIVKGGVPKEEALAWKQAIRDYAKANSDKITGFNSTFEIIPGIPPNDIVFYEIYNSKAQTAARAHPALINTQRTLMSLWHVSNPSTPISLNTPLTYFDRLRIRPPGPSVFTLGCHIDGGSVERWEDPGFRKCFSKILQGKWREHDPFDVSPRIDAKQDLYHAAYVTSRSTRELFLRLLCVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVJ0</accession>
    <name>A0A2R6RVJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVJ0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="133" mass="15115" checksum="3D77AC444F3AFC0B" modified="2018-06-20" version="1">MFYQPQPLCKAARHEIIRPRLCLGDFTSSIDDMSHLRQLPPPSYHVADSSALMVLWFWGRTRYSFRADAHKGFRASPGGPQVTRVFVRQDERPIWIRGGADKASTESVRMWTRGSIAGQSISDLGLTYLSFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVJ4</accession>
    <name>A0A2R6RVJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVJ4"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="692"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="295"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="760" mass="83706" checksum="9280A9194395E7FE" modified="2018-06-20" version="1">MPSRNLPSRRNSISCVRFSEELEVLPRDGRSGDTNIGTPPENSSASALPQSRFSSTAGAVADWQFPDTQSATEPAATQSHDTGRNFLNTPVDESRRGSDDTLYEKSDDHDEQDLSRFSLSSYRHPYDIKRPPSAYTGSSTIQDVPPGSNARVFKESDVSTNEYCAGDKEDPEKAVRETCQQLPRRRRGYLTHLIDLYNTYGEPSEEGEQASHRRSAVLQGSRRDSRLVDPLAYDEDQPLEPDDPFVTGIHKQCLEDVEDVEKNVRRSMSYKDRRKEQQRIRIEFNVTSIINRQKFLMKLANALLIFGAPSHRIESQLLSAARILEVDAEFTHMPGLIIASFGDEETKTSQMHFSKCGGRLSLGNLHKLHQIYRSVVHDEISARKATDDIQTLIDSGSVHRTYVRLILAFLIAALICPLAFGGSLVDMWIAGLGSFFLCSIQIGIASRRNIIYANVFEILSVIGISFFARGLSVIRSQVFCYTAISSASVVSILPGYLILTSSLDLASRNILCGSIKMVYALIYTLFLGFGLQFGSDLFLLFDESARHELDTLAARAAAAITVTGTYIADNDAAIPDGLATIGSFTFTPSTPFIRQNISQGCYRPPAFPWYLQSFPWWTQFIIVPIFSILSSVNNEQPTNWDLVVMVVISCISYTANKVADHFIFNRSDVVSAIGAFTVGLLGNVYSRKMGGTAFTTMVTGVLFLVPSGLSEAGGITAQGSATQIGGAMISVTIGITVGLFMSQALVYMFGSRKNAAIFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVM3</accession>
    <name>A0A2R6RVM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000158">
        <property type="protein sequence ID" value="PSS34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVM3"/>
    <dbReference type="STRING" id="98765.A0A2R6RVM3"/>
    <dbReference type="OrthoDB" id="2786161at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="192" mass="21860" checksum="F2680E118194BF86" modified="2018-06-20" version="1">MSIYILLLEEGKSDDILKKDVQFFHDLSLRDARKHLPRLRALAKKHYPEVPYWSLIVCIDYNMLPPIFSVKHLDEYTLGNAQRSSIVEARNDAMIEKIKNKQGKYALLETRLSFGTGMQCVFTLATGDFWNSDNSLIGGGHVEGEPHSEDEFDDEGGLEDELKGTALDEVDEMMVRMILNNFMKSNGEQPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW05</accession>
    <name>A0A2R6RW05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000140">
        <property type="protein sequence ID" value="PSS34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW05"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="11935" checksum="EA1706BDE25D5373" modified="2018-06-20" version="1">MDQLAANNRRRKDIYTLPRADQELIASLGYKDKLAEADKAILANAEFLKQIVANPEIFGHDVDYEDECVQGDTTRQGKVERDLCYEPMKEALLKHFVHVTAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZH3</accession>
    <name>A0A2R6RZH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZH3"/>
    <dbReference type="STRING" id="98765.A0A2R6RZH3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10777" checksum="54FE1B55F5401AE8" modified="2018-06-20" version="1">MSLSHYMYRPKRRLQARTGSTASSYDVRTTITTAQDTFQSGVWSKAPALQRSAVLSTLARIVQENVDAFAELESKQTGRTIREMKAQLSRLPEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3M9</accession>
    <name>A0A2R6S3M9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000094">
        <property type="protein sequence ID" value="PSS36894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3M9"/>
    <dbReference type="OrthoDB" id="2349883at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="421" mass="46605" checksum="67208E909318B4AB" modified="2018-06-20" version="1">MSLLDPEAIHVKAVPFSQELTNQHGSDVLCIPYTLSPFSLVDAAKSVPSASAVISEDWRIDPATISSELVAAYPVLLPVYLARYDAEEGLETSELTVVMEAHQPEVNIIMHNFIQDRAKTFGVPEDGFLGRLAKVVTETDFLQVTAGAIFPSPMKPFFANIEHILVAPRMRKRIAELTEWIVWKAYSATAMEKYQEFEQSQRKAARLSEGVDFDDVRIREFSRAEMDSVMSYMSMGTEVVLLRDMIERISITNVNGEHQGKVVHIDLGSASNKEGHDASSPKSPLSVQPLDQFLIDLKQKLEEAEKKEQERKPEWLKQWQEQQKHLDDSKTPKGARVAGAPLGFHPGGAPSVIEGAAAVDTEVTSCPLDVRMKVNNVGEGDTVGMAVALEWRVPRTAEYVLVARPEETILPTGALTEVLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3W6</accession>
    <name>A0A2R6S3W6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000089">
        <property type="protein sequence ID" value="PSS36984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3W6"/>
    <dbReference type="STRING" id="98765.A0A2R6S3W6"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="687"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1043" mass="111691" checksum="41CCCC116CF57E52" modified="2018-06-20" version="1">MSTRIVTVEDPPRSVSVMDMRSNNPFLTRTSMFFKKVSYLKNVRRKSDERKSAGGFPRNARSVELGTKAFGMSQPILGVSTDHCMTDAGDLSDPSSTVSDSPTNTNMSKPSEVTKAHTSKTPAANADTASRADAPNGLPSLSPQQPSTKPVVDGLPPVGDGHLFSNELNGYLTDTAFSKQSSSATSNITIAPVTDVGIVESDSHGSDQTFHSATEHIVVSSSVEATFSNTPSFTDRALTSSPPPLDETSPSPSSPSVSRKVNPSTPRNPFITLDTTSAQSRAQSLPSRNLLSPNATPSLSSTPLIVPTSPVDSEATVTPRAIHPRLASLPPPMMARYATQGSARLTPSLGPRQPPMPILNLPTLPLPTPRTPPPTAAQTQSPARLRGVPALPLRGPSEFAQADHDNAGLDDMEEMDEDDGEGDDELPAAHLSDEDDDSPQHEVPMMGRRLRSPLPPSLSRSPRLPALPPVDTSSFSVPFRLLTPTGTVTARPDTVYLTPSEPIPTDILRTPIQSIRKSPAFAAAITDYFTSQQPESSDDATYTPRPRDAMDGLVAPRTVPMPNTSPRPGLYHQGSKSMVDLLSMSRKGKEKEPTEAEKRISRAPDYAMATSRDTPENEADVSAVAAKTADVPMTPPLRRQRSLPMYNTATEPPPYPSFLPQRPHAPLLYIQPREEEGREQLPKYANTIYLSAIMPRKLEFTAPGQQAKDRKWKRALCVLEGTIFKVYRVHGGVVEDWWERAVGVGDRTSVDPSAMGASGTIRVSAVREPERGERERKGEASPWPDATAANAQGSSSMAGPSSHPPASRSKLHLAASLLHPSRSHASKLGISSNSNSRSRLSLDTRQEGSRTSASSMPPRQSLDSSRPARSTSASSSRLTSSNPPSDSSTSPTSLSTSPTSSSLSGRSTSATSHFSGSSSGCTVSQEPDNKDLNRAYTLQNAESGLASDYTKRKNVIRVRMEGEQFLLQAKDVPAVIEWIEGIQAATNIALDLDDRPMPKGPIFPRGVGGSSNRGADVVVEGLAAQKAKVKITPLLHPRGQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Y1</accession>
    <name>A0A2R6S4Y1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000063">
        <property type="protein sequence ID" value="PSS37303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Y1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Y1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="559"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="724" mass="81634" checksum="2D9E5FFBE5B99D5F" modified="2018-06-20" version="1">MDAFGTVMTALHAAHKVYEVVKKLRDAPEEIQALQDQIKLLDNILPRIKDVLQRGGDSVSIDLLVTKAEELTSSVSKFHDKATAMFQDKRKMKRLKWLFKADEAKALAEKLKAFYGSLSAVCAAHSIEFPDLIRASLTELDQKLEESFASVHHRLQDGFTDVHVHLDSTLNATLVGVREVVQEELTMSMEIFMCILVTTLKREFRTMANEQRRGESHNFDQYSVLYDTSDVAQATNVQYTSPGQSSTSAQRDNLPSAMTPTAFHHLPPLVSLNEPPCKHCGCQCHRAASVWRTPKSLGSIVGNHYVKIPFPHRLWPGMVQCDVPTCKKGWLMEVRSSLPYWFARVEMQTRVEALPVHFCIQTPRVNPEINDKLSGTVLEGGADVFKELLYSRRATINDVDTKGRSLLHLAIAYINNARTYLQLNNVITAISYLLEVGVPREWQDDNGRSAAELALYWIQILVDDRASQLQLLEQLQVRVIGPLLQDDLNGVATRFGMTELHQRLFLPGPRLTAEGLVDLVPLRNTPDREGWTPLYYAIRWAPYAVEMLLNAGAGLVHQPLRVAMTFSDSTAIGLLIRAGADVNERDDPGGCTPLIYLTKWTLFNQRCEKMNELMRHAGDKIDWDARDDNGKTALDYALEERGSMKFVRLLKRYSSRDILEQGRGSAIQVGNWGWTYGDDGYAYLYHGYSWSVCECPLCVVEGTRIREVTTEEEEEASMPGGFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S550</accession>
    <name>A0A2R6S550_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v724</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S550"/>
    <dbReference type="STRING" id="98765.A0A2R6S550"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="851"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="950"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="988"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSS37420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111137" checksum="A596B1083D59389B" modified="2018-06-20" version="1">MLLEAPWTQTPEEILQHYSVDATRGLSSDLAAKHAELYGKNGKHIALACLQDNLVFTPLIHHVELPEDPPTPLWELILEQFKDQLVLILLASAVVSFVLALFEDSSDSSWWSAFVEPLVILLILVANATVGVIQETNAEKAIDALKEYSPDEAKVYRNGQVARIHASELVPGDIVSVAVGDKIPADCRLLSISSSSFRVDQAILTGESVSAHKSVGVVADPRAVKQDMTNMLFSGTSVVNGTARAIVAFTGDRTAIGDIHKSISSQISEKTPLKRKLDDFGDMLAKVISVICILVWLVNFRHFWDPAHHGALKGAVYYFKIAVALAVAAIPEGLAAVITACLALGTKKMAQKNAIVRNLPSVETLGCTNVICSDKTGTLTTNQMSVSKFVVVDPTGKPKEFLVEGTTFSPIGSVKFADGKDASAELRSEPLLRLAEIGSVCNDAKIVFNAEKGTYSNVGEPTEAALKVLAEKLPCPDAELSKSLSSLSPTVRASAVNDFYERTIPRLMTFEFSRDRKMMSVLVRRNGAGALFAKGAPESVLERCSSVLVNGHTIPLTGELRSALLHQTLSYGSQGLRTLALAYSDMTDVDPTHYQTENTTDYARFERDLTFVSMVGMLDPPRPEVRHAVANCKAAGIRVICITGDNKRTAETICRQIGIFGEDEDLTGKSYTGRELDELSEGEKLQAVMRASLFSRTEPGHKSQLVHLLQSQGLVVAMTGDGVNDAPALKKADIGIAMGSGTDVAKLAADMVLADSNFATIELAVEEGRLIYNNTKQFIRYLISSNIGEVVSIFLTVLLGMPEALIPVQLLWVNLVTDSLPATALGFNPPDHSIMRMPPRNSREPLVGKWLFFRYMVVGTYVGVATVAGYAWWFIYYVGGPQITFHQLTHFHQCSTLFPEIGCEMFTNVMAHHATTMSLSILVTVEMFNAMNSLSENESLLVLPVWRNPFLVAAIALSMALHFAILYIPFFTSLFAIAPLNWTEWKAVLYFSVPVVFIDEVLKFVTATFVAPPSKMKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5Q1</accession>
    <name>A0A2R6S5Q1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5Q1"/>
    <dbReference type="STRING" id="98765.A0A2R6S5Q1"/>
    <dbReference type="OrthoDB" id="3047760at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="271" mass="30144" checksum="BAEB04D9BCCB26B0" modified="2018-06-20" version="1">MAAQVARIPFAILSLNESFPHADIATQLPQIAAYDIHIDAGTDVTAEVMHKAKVIVKVLESLKGDLNISEEMIATARDRVSALQQARLMAGTVTPDQGAVFTEAQVQQLQNIVQNIVQNIVQNSLQPFRDEMREDMRGLRDEMREDMRGLRDEMHEEMQSLKFRLDNNATAQRNELLLETKPAALECRKKQVPGDGLHLCQQLGVVVGANPGDPPLGSKFRDEIDTGNLTAAEISGMIRFYNETFGIVAGDQLQQRRIKVSNWLCNLPTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5Z6</accession>
    <name>A0A2R6S5Z6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5Z6"/>
    <dbReference type="STRING" id="98765.A0A2R6S5Z6"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="287"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="560"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="681" mass="72058" checksum="ED3CEFE7E45C64DA" modified="2018-06-20" version="1">MLRRALFSPTKCTLRSISSLPTALSNLAPIDVHPEVQEALAKHRPVVALETTIITHGMPHPTNLETARSVEGIVRDQGAIPATIGIIGGRIKIGLTPQELEHLAHIGNANPPAVKVSRRDIGPAIALKRDGGTTCSATLIFAAMAGIKQQLGLANGVLFGVPIPEDYEAVGEQLQQAVEQAVIESEENGISKCGKAATPWLLNRVGELTQGRSLASNVALIQNTARVGGQIAVAYARLSEDQRGLRSSSTYPTPDYTSYNHGATNRIDSTVETATKTPESDPYSPAELLVIGSVAVDITAQAKASDIASGMHSTTPGSVSMTLGGVGRNIAEAAHRILTASSSTLSRATVLVSPVGQDSFGRLLTEEIGRLGMRTDGIFNVDSGRSAVCNMILDGSGGLISGVADMGITERFDPKIAIEAIAKYRPKIVAVDGNLSELCLGAVIGYCKANNIGVFFEPTSIVKSTRILSAIATSLKQSTQVGPGSPVMFASPNVLELTEMHMEARSEPLELTTHPTWWDAIDNMALGTPFRMNLEQLARQAACDHSPAKGTLAYLLDKGVAQMAVQLLPFFQHLIVKCGDLGIFTVFRIPADVAKESAWVNERTNIKLRQVVAQGKDGEIVVLKHFPALPLPEANAVNVTGAGDSVVGSILASAVENPIAFQDPATLDRVVERAQKVRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6S0</accession>
    <name>A0A2R6S6S0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH15-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6S0"/>
    <dbReference type="STRING" id="98765.A0A2R6S6S0"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="109"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="383" mass="43812" checksum="859E564E6DC125E0" modified="2018-06-20" version="1">MRELFEATNNYWNAWIRRSTYQGSWKEAVNRSALALKLLIYEPTGAVIASPTFSLPEYIGGTRNWDYRASWIRDSSFTLYALIRLGFTHEANDYMDFIFDRVKQKNDDGSLKIMIGNGAIDHVQLDIYGELYGQFSTFSLGQANEFFSEWIVFILGRSMVDHWVAVRELEVRGKQKHFTYSKGSYRQRLLGIRLAEKRSFPCPRRNEWITARDTLYEQIMEKAWNKELQFFGQSYEDTDVLDSSLLIMPLVFFSTPADPRFLNTLKRILLTPERGGLTSNGLVYRYDVSKSDDGVGGEEGTFCLCTLWCIEALARAGEYDKPLLARAVAMFEDFLQYTNHVGLCTEEISPAGDGLGNAVQGFTHVTLISAAYNLSRMQGKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7B1</accession>
    <name>A0A2R6S7B1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v88</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000007">
        <property type="protein sequence ID" value="PSS38069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7B1"/>
    <dbReference type="STRING" id="98765.A0A2R6S7B1"/>
    <dbReference type="OrthoDB" id="2802833at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF36">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS38069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="249" mass="26560" checksum="113B98E20DCB195B" modified="2018-06-20" version="1">MSAKNVNSLIAGVPKLDGANYHDWKFNMQMILRRSGSWLVVNGTTSEPDEDDSAEYLTWHAHSEDGLTAIGLSVDQSQVAHIRDCTSGPAAWKALAAIYERNDCATQISLKPIGVDIPDEDVTNILIYALAPEYNAVATSLMQSADDTLSIASIMGTLVDAEAKMSQNSSGPSVAAYAAKTRPSGSTTTPSSTSAPRPPPTCYRCGEVGHVARSCPAPAPVSSPNSDNTLAVNRAWLPRSDDDEYLQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE21</accession>
    <name>A0A2R6NE21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001348">
        <property type="protein sequence ID" value="PSR70581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE21"/>
    <dbReference type="STRING" id="98765.A0A2R6NE21"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="119"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="295" mass="31975" checksum="2026868797B0B6AB" modified="2018-06-20" version="1">MATDYSQRVMLNSGARQPEPHPYLHEPLLYISGLPPSVSDQDLALAFQQCAPFRPNVARDGSGLPISGTIEFKYLEKAEKALATLQSRPIPNHLPAAQLVLSPYPSTTPPTPLPPPSASPRLVKHLPSGFADSQLYDLFRPFGALASVRTQAGFGNDTGVVEFWREEDARDAEQALHCADVEGQNIAVQIYQPRKAGAAISEFSPNAPAFVPTGAMVAYPTQYSPPRTAPYPPRSPLSFLHGPGQQVQYAPMSGPGSTSHSGLIDPCNLFIKNLDTSIDSNSLFSHFRQFGQIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEJ4</accession>
    <name>A0A2R6NEJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial distribution and morphology protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v13322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001315">
        <property type="protein sequence ID" value="PSR70800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEJ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NEJ4"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR70800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="80082" checksum="2304D77966B19A82" modified="2018-06-20" version="1">MSLAARTTSSILLARFLGPRHDRAVLDRYGLVRRFFLRQSNTQSCDSLPPLVPRITWVSYGIRPHTKVVTLSYPSLTSQRPRDGWSSRAFHSSSGLREQKKRNAAESGDNGTDAAKNHNLDKPVVSSTESDLHRFDNYSTFFRKLAMSLPHMHRPSREDFLHAATGFWQRMRVRFKWLTIRSFRKYNADDISAFVTWFFMSQTLWLFVGTTTFFSVVFATINSLRLQHHVARAISDYLTSETGITIFFESAIVPKWKDSRISFKNVYITRRPDAAARLLADKNAAHHAARGYDVSNHPSNHEISDEDDEPTKGNLHSEDTNYSMFDLTVDSIDVTLSLARWLEGKGLIADAVVKGVRGVLDRRSVHWDPEHPLDPASFRHIDQPGDFELESLQLEDVLITIHQPDEFRPYTASIFRADIRTFRKQWMFYDFLSAENVVGQFDNCLFSLHKPQSIGRTTDQDLKDGQWARMSRFRIDGVNVDHMQAMTTHEGPISWITSGKLDAVLDIKFPRDHEDGTPFNALIGEIADAISIAATSAVADRIPGQRALAKPPLSAPSDQTDARKGEDDHRKVVVDIDMRFRDLKAAVPMFTNDLSYANNALIRPIVAFMNANRTLVPIHCRVVKDLDDFDGAWTVYEAMAYHVTQANFNRRIKAVSAWSLQMTANAILSTLRSVTDPMAVHLRELYTEGFPYEVYRVGIVPNNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEM5</accession>
    <name>A0A2R6NEM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding protein Kin17 WH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEM5"/>
    <dbReference type="STRING" id="98765.A0A2R6NEM5"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Kin17 WH-like" evidence="6">
        <location>
            <begin position="52"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="303" mass="33996" checksum="162D6E1CE50549CF" modified="2018-06-20" version="1">MPRAAVGTPKYLANKMKAKGLQRLRWYCQVCQKQCRDENGFKCHAQSEAHLRQMLVVGEHAGRHIADFSSTFQHEFIQLLSRRFGTKRVKANTVYQEFIQDRNHLHMNSTRWVTLTEFAKHLGRSGLARVDETEKGWFIAWIDNSPKALAKQEASMKKERATTSDEQRERMLIAEQIERAAADTDGSGSGESPPPVEVGLQRDEGAEKVVLSLAPKVPATATAPISMGLKLNPLKLAVNPLKGGANPLKRTNVFKQATPLVPTASLEGEKVNGKKRDAPMSAAERLIFEDQERKRRRMEREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG71</accession>
    <name>A0A2R6NG71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG71"/>
    <dbReference type="STRING" id="98765.A0A2R6NG71"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29594" checksum="C46BC38FA9855211" modified="2018-06-20" version="1">MEQEDESDDDVSLISRSPSPKPRDDGMDIDKYDEYARGTPHEPITVDTKISSSNKGFAMLAKLGWVEGQPLGLSGDGRVDPIPFVPKSDLAGLGKASQDVRMIESTVSQRRELDSERQVKETEDQRRAREDSVVKRAAVRSEISTVLKAFYCELCDKQFQNVAQYDEHTNSYAHHHKARFRDMQATQRANLGNSREETDKRKEKERKREEKELRKIAKAAGIKMPKPPAPVAPPNNEPPPPPPSEPKPNGFKKSGWATVGSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGA1</accession>
    <name>A0A2R6NGA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGA1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="27927" checksum="0CD15234DD4988BA" modified="2018-06-20" version="1">MKSFVKQFPTEPEALRMALFLDEVIMNAPGHLSGIFPEARKSVQELLIGIPHSRLYFPNPGHSSMVQPRIRRAFNQHLRPVSEMSHLRSFTFTIVRPHSSQQPHTQVWPLFLDLLFLLPKSVHSVTLIVHTSERNVQNSNDGGDAWPHGTTPTDWERMLEGLERLSELKLLRIFENHVLPDGRFSVEEWKEKEVIENALGKLKQRGVEIRVMSYGRGDWGVRECYARTEGERRDQEARMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGK6</accession>
    <name>A0A2R6NGK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001273">
        <property type="protein sequence ID" value="PSR71517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGK6"/>
    <dbReference type="STRING" id="98765.A0A2R6NGK6"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10192" checksum="3953934978E1CE56" modified="2018-06-20" version="1">MKRALIKSAFKTMRYDQACKTGSDVIGRTNILNGFTYNVTGCTSTNYIQCLHSDLVQWGAVSNQTARTVINPVMSARLTTKNSHHICPVRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGL4</accession>
    <name>A0A2R6NGL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGL4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6326" checksum="3515C69AE38395FA" modified="2018-06-20" version="1">MLYTTPCGGTEGKYQYARLPSKAVSGVAEDTVLGREADVTSANYQSCRKENFRFGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGR5</accession>
    <name>A0A2R6NGR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001273">
        <property type="protein sequence ID" value="PSR71519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGR5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9622" checksum="53966F4FD04FD55B" modified="2018-06-20" version="1">MANSDPDGMWASSPASRSSMIFGSSGNLMHSTPLTPLPPLGPPHMLAPSAFEGASSPDGAADMYKNPYQRYKRGENERGVWRIQINSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH21</accession>
    <name>A0A2R6NH21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001250">
        <property type="protein sequence ID" value="PSR71687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH21"/>
    <dbReference type="OrthoDB" id="2741429at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="138" mass="15318" checksum="D481EF784BD3E5AF" modified="2018-06-20" version="1">MSSSETKFGKDYLCVPRLDVSGANWIIYKDRLQFAADARGYLDHIDSTKTIPIPPAAPTLLPSSPSPNAAALTAHAKEEKKYKEDLAKHEKEVVTWKCVEGIIKQLIAGMTPDSLFIKLRHSTIAHTMWTTLGKQVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH40</accession>
    <name>A0A2R6NH40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001269">
        <property type="protein sequence ID" value="PSR71568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH40"/>
    <dbReference type="STRING" id="98765.A0A2R6NH40"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="672" mass="75475" checksum="30206CC8163E04C5" modified="2018-06-20" version="1" fragment="single">MSVTTGRPCSATGDFLPPGTPAPSHTSADPADWAPYADRIQFETAEFLYKRTQMSQGNVDFLMDLWAASLLQHGGVPPFANFKHMHELIDSTPLGDAPWATMEASFIGDLPNNPPSWMTAKYELCFRDPRVCARNMLANPDFANEFDAVPYREYDGRMRRRYCDLLSGDWSWRQADLIAADPNTHGAMLVPLVLGSDKTTVSVGTGDNEYYPLYISLGNVHNNVRRAHRNAVMVLAFLAIPKADKKYRKDPRFRKFRRQLFHTSIAAILQPLKAVMSKPEATRCPDGHFRRAIYGLGPYIADYIEQVLVGNIVQGWCVTCPTLQANLEQPPDGNIRCRAYTDAVIAGMDLKSLWQEYGIVGDLILEHGETKAQEIMDQIDRRINAVPSFPGLRNFKQGRDFKQWTGDDSKGLMKVYLPAIADFVPKDMLRAASTFIDFCYLVRRSVHSEETVQQIEDCLTRYHQYREIFRTTGVCEDGFSSLPRQHSAWHYPGHIRNFGSPNGLCSSITESKHIKAVKEPWRQSNRYEALSQMLLTNQRIDKLAAARTDFKARHMLDGTCLSATLQAILAEMTAEENVDAEADAAAEQPLDEDDEDDAVGVVEGGRVLGDVVLARRPARGYPRDFRSLGAHIGVPNLSRLIARFVYNQLHPDAQLADDAPTPRRPDIEGHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI64</accession>
    <name>A0A2R6NI64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02001222">
        <property type="protein sequence ID" value="PSR72074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI64"/>
    <dbReference type="STRING" id="98765.A0A2R6NI64"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="60"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="584" mass="63986" checksum="C664368DDD7D9DB3" modified="2018-06-20" version="1">MATVETITQEIAEANALFNDARKQGADAAIIEGHKKKLGDLKRALGQLQGGSKDAGKKKERLLLKTAKGTRDYGPAEMHCREHVERIVKDCFTAYGGGCLDTPVFERKDILAGKYGEDAKLIFDLKDQGGEELALRYDHTVPLARYLAMNGAMNTQAKLWQVGKVYRRDNPVMSKGRMREFSQADFDIAGVWDPMIPDAELISLLCTILTRLEVGEFTVKLNHRKILDGIFEVCGVPSDKIRTISSAVDKLDKLPWADVKKEMTEEKGLDPVSADKIGEYVKHKGGPSLLQTLRADGALMANPSAKHGIEEMGILFTYLEAYKVIDKISFDMSLARGLDYYTGIIYEAITEASAPPGFKAANALASSSTQPFTSDVTPPAPAPKKKPKKPTSQDEEEEVDESQVGVGSIAAGGRYDNLVGMFAAAAAGEGKKAAGLPCVGVSIGLDRIFAIVWPKWVERGMRSKDTMAYVMAAGDGLLTDRVQLVQELREAGIKTDFLFKNKPKLPAQFAAGEKDEVPFAIILGGDELKEGLVTVKEQKWEFMDGEKRKVQSADQGTKVKRAELIQWLKNTQTYQGWSSGKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ70</accession>
    <name>A0A2R6NJ70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ70"/>
    <dbReference type="OrthoDB" id="3225366at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="173" mass="19729" checksum="55DD74EB57576772" modified="2018-06-20" version="1">MQSALFAGIESQLLGFVKGEIQDVANFQGQALLAFTYITLFLSVSATMTSLILTDEFGELPLRASRRPDSQRLNKATTFDEASHKLLSRFGGSAAWRWVMWHWLFTLILGYICFVVQIVLYVWLKEELAIRIVVLIIAIGTTIPIFDLFWPRQIEQEAQNEEKDVEVDVISDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ84</accession>
    <name>A0A2R6NJ84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001192">
        <property type="protein sequence ID" value="PSR72403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ84"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ84"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="9183" checksum="5CFF1576010F38E2" modified="2018-06-20" version="1">MKYSPSESGHFDGQRGYGYISIEKFIDAARSIKSGTSVPADFDAHGLPTIANTILTTAILNAGRISLDEKRPVNIKQNGSGWTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJE9</accession>
    <name>A0A2R6NJE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001160">
        <property type="protein sequence ID" value="PSR72515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJE9"/>
    <dbReference type="STRING" id="98765.A0A2R6NJE9"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="322"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="390" mass="42532" checksum="075356CFBAF8BE67" modified="2018-06-20" version="1">MASAVAQETQQEVPRLTLSVDQSASTSPFPSPGSPFLPPPKLGAHEFASKLSPVDHIMRTAHTKRRSKEGDNGEATTDGQATPTITTPNSPPVTPTPHTFRLQQQITPVTIPDLTQSSSLTTPDKLFQRESLTSSRPAPPSPALSRRTSAALSRRSTASTRSRAHSRVTSFSQQQPEESAHRTEASSSTVSPTKRRSLLIKIRDFAFPQSDNRHFGRGSDVPRANRPRRRESTSSTSSSSADGEQEVEEEQWHDTRTIFQLNTLSSHFWGGKSGESEESAAGPSRTDFDRNFEASPTDENSQEDYDDTEEDDYVPPGEDGPLVSGTYRALYSFDPEGTAEMALEEEQVVHVIGRGGGVGWAIVEKEDGGHALVPESYLELVQADDTDGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKF9</accession>
    <name>A0A2R6NKF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001161">
        <property type="protein sequence ID" value="PSR72502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKF9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7408" checksum="4C5887460BFB5505" modified="2018-06-20" version="1">MAAQNPSLSDVSKAFLAVPELRNNGTNFKLWRARIKAATRTIGNKAILTTLHTDANFDGIIAAAIQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKS3</accession>
    <name>A0A2R6NKS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKS3"/>
    <dbReference type="STRING" id="98765.A0A2R6NKS3"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60294" checksum="96579A99BA4FE99A" modified="2018-06-20" version="1">MALAKAKSTQNGGGKKPAKSPAPSTGASTPVTQVTTSTPADQLSYGSGRPDKSLYDSEQNKLKAEIEALQSKLNDVKDKIALANKGGPGQERRNQLLAEIKDIRNEQGNIKQTRSKIFEQLKALQDGIQKKVKDLNAARGKVSFRSVSEVDERIKQLDKQVESGSMKVADEKRALAEINQCKRNRRTVEGFQNEQESIEADRAQADELRKQLDDPEGKAISERYDAIQAELDQLKSEGDKAHAARGKLMDERTEIQGQLDELFNQKRDSTMRFREANDRYWAKVNEDRARRAERMRAQRAADDEAKKKEVADRLREEAEMPAFQAQIEDCQTLIDYFSGKSSAPPKLSTDAEKEKANLAGVPQLEIRKVEAASDGMVMRKKKGEEEESYFVGGGGKQKKGKKHGAKVTPTSDSTGTEAPSTDRVNIPLATLSALLSLSIPPPTSTTDSPRVVEDLQTKKAWFQANQSRVTAENKAKVEQEIQRLTGKHAKVDVVPQTDELTPPNGGAEHPAEPAPTPSVKSLDVSTAVPGDEVEGALESVKETEDAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKS6</accession>
    <name>A0A2R6NKS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001122">
        <property type="protein sequence ID" value="PSR72979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKS6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="9452" checksum="B242561B5B9DCF1D" modified="2018-06-20" version="1">MSVQHKILCMANAPTTAAREVDIRGGGVRIRVAGDRGGECGSRCSPEDLRDDRLLSVCTSRALAIKGKERAMERSQVLRHFSREPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKU3</accession>
    <name>A0A2R6NKU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001122">
        <property type="protein sequence ID" value="PSR72973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKU3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="167" mass="18855" checksum="76A21F8DCD0C74B0" modified="2018-06-20" version="1">MLVAIPHLQGTHLLLSIRKLAADRQRRFSLDGVSTQVPFFVKPSPDAPESIELQEFINRQTQGSHLLSPDTPVARGRDAERGQVTEFDHDEDRLRIPPNHSRSKNQRAPSPPHHNDAQPVSSEQGTALQDSAGGLPPLALDPPFSIQGIFARLSRRWDWDWLKDWEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL62</accession>
    <name>A0A2R6NL62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001105">
        <property type="protein sequence ID" value="PSR73117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL62"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5771" checksum="D4E8E6AEAC6EAE98" modified="2018-06-20" version="1">MRIPGIASLRKSKQLLRSNTSRGCKPAHVWFREWVGDNQVKTARTMKDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM08</accession>
    <name>A0A2R6NM08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Asparagine-linked glycosylation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v10836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001085">
        <property type="protein sequence ID" value="PSR73308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM08"/>
    <dbReference type="STRING" id="98765.A0A2R6NM08"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015329385" description="Asparagine-linked glycosylation protein 2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="9">
        <location>
            <begin position="202"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="725"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR73308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="866" mass="92676" checksum="E8BCF6ACE2997E60" modified="2018-06-20" version="1">MALKAFLLSFLFAFPLAFCAPLDESQSPTASVQYVWVTEVVTSDVEVLETSTILVVTSLPLTTAPPTAILPALSPASTSISSVPPTPVFDTVTDIITLTATVTPPPLTITVSAAPTTVTEILTNAPIPPPVAAPTAWTAPAQMTDLDAFNVSSFAYGQHNMKIVDGIPAAASATTSAALALAEATSTAEPQGSAIASSMWDNSSTVVQLFYPAGSINPGSEPQGGADFYASPLDLSQANNVTLEYSVFFPAEFDWALAGKLPGLYGGHRTCSGGDDALSCFSTRLMWREGGAGELYLYAPKDKQTEPLCSTPPLSVCDADYGLSVGRGSFNFTPGAWTHVKQTVTLNTPGQQDGGFVLEVDGSEVINRMDVFYRDVPSESSPSTSDGPPETSSPPMPPAIAPAPVPSLPPELPQPQATPGGLSGILGPLLNGLQLFRAFGPFSSLPTRATRNKPIRIVEPDKRMDSMDIDLSNTATLTLATTVTTIAIPATQTVSLQETVTVTLPGEMSVSTEPLRTQEHADEKPVQFTGKFHILLSNIRQLHLTAHLLWPSTPTYDVYFVDQLSTCVPLLRNFARTRVVFYCHFPDKLLADGEYVEGRVGRSGGLLKRIYRFPVDWLEEVTTRSFEKKKNAALAVDAFALLHKKLSADSPLNRLRLVLAGGYDPRVEDNMMTLMYLIDRAKSHSLTYDVIKPSSSKVTIPPLNSTPNDPSVLFLLNFTTAQRSALLSAPSTLALLYTPTNEHFGIGPVEAMICGVPVVACNTGGPTESVVDSDEGRTGWLRAPDPEIWAETLVGIVGMGEEERRQLSERAKRRAKDNFGMEAMAISIERALKEAVGMGAVPLSWTPLAFIFALIVLLAARSLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM78</accession>
    <name>A0A2R6NM78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chalcone synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM78"/>
    <dbReference type="STRING" id="98765.A0A2R6NM78"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877:SF46">
        <property type="entry name" value="TYPE III POLYKETIDE SYNTHASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chalcone/stilbene synthase N-terminal" evidence="4">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone/stilbene synthase C-terminal" evidence="5">
        <location>
            <begin position="250"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="43710" checksum="7F203D9F202AB058" modified="2018-06-20" version="1">MSPHKVLAEAAQQSFPEVDLHIMGVGSQYPEHTVSPQEFREFALRHYPRTPALEKVLAINENTGIDVRSAACSVNHPMLNQPHAPTIDQLSEIFLTEGVKLAVGASRKAIEEWGGDISQITHVVATTCTNSANPGYDYYVARELGLSGSVERTLLHGVGCAGGLAVLRNAANIALGASFLGRPARILVVTCELASLMARSELDSLNQDQDLRIGMTIFSDGSSAVVLSNGIGESPESKPVFDLLAWDHRTLPETDKDIGFDVHPNGWKVILTPRVPALASTSAPPLLNSLLPRIPSLADRAIPLAPQDFDWALHPGGAKVLTSVQKLLGLTPHHLRASYDVYKNHGNSSGATIFSVLNRLRDMGEGREHVVGCAFGPGVAIEMCVLRRHRVPSEVQAAPASGSSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM85</accession>
    <name>A0A2R6NM85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001074">
        <property type="protein sequence ID" value="PSR73499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM85"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="11482" checksum="EB65A1E68399F28A" modified="2018-06-20" version="1">MSTTAVNINTSKAEQLVLDASQLMIKTDADDRGTMAALMQEIDGISAETQWVRPTLVRFYSLQPIANLFQIILRLSNVYWECDGSLASQDRILTLQHGIPIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM86</accession>
    <name>A0A2R6NM86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysophospholipid acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM86"/>
    <dbReference type="STRING" id="98765.A0A2R6NM86"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39040" checksum="B66C1E1C8A0BDCD7" modified="2018-06-20" version="1">MNLIDGSLFKVIDKETEERRASVSVPGRLVPRGRKRVAYRKMVMGLAYLGLFVVMGGQYNFGIATQDWFPKKSLIYRVAIFQICGFLERSKYYAIWTLTEGASILTGLGFTGFSPSGATRWDGAANVIVGTIEFAPNMKVLLDSWNMKTNVWLRECVYKRVTPKGKKPGFRSSMITFATSAFWHGIAGGYYLTFLFGGFVQTVGRLCRSHIRPLFLPATYVASRTAPPPPQTFIKRVYDLVGTLTCILILNYLAAPFMLLTWHDSILGWSRLAWYGHVMIVSAMAFFYGGGTGFLKRIQAARVKKAGVGKSETNGNGTPSGATTPNLVQTLPPLDDVAKEMEKTKFMRNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMC9</accession>
    <name>A0A2R6NMC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMC9"/>
    <dbReference type="STRING" id="98765.A0A2R6NMC9"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR73446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="416" mass="44041" checksum="4DBB54E584C019E9" modified="2018-06-20" version="1">MPSSSSIPPNAPNSDSRPPLKLQKELTKAERRELQERQRAAKLASKGGAAPSGSMAKSTPKPGAQAPATSAAPKRGRRPSESAPRAPAVAPGRAAKDAKIAVPSTLEPSPGNARSLRIFSHFGLPKTVSVAKGDIHPAILRLALQFSNFKITGANARCIATLTAFKTVIQDYATPPNNTLSRHLMTHLSPQISHLVAARPMSVTMGNAIRQLKLEISGSDIDLPEQDSRSSVVEKVLLGAHSEGRTFSVIVVDSRPMLEGKRLLSVLAEAGIQCTYMLLPSLGAVITEVSMVLVGAHSIHSNGAVYSRAGTALVAMLAKQHSIPVVVCCETYKFSEGVQLDSFTKNELAPLGDQFASFPLTKPRESLTLNNGPHLEILNPLYDLTPPTSITAVVTEVGVIPPNSISSIPLALGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMD5</accession>
    <name>A0A2R6NMD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMD5"/>
    <dbReference type="STRING" id="98765.A0A2R6NMD5"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="296" mass="34033" checksum="A228EF1D37CFEE54" modified="2018-06-20" version="1">MVESPKLIALRARAAALHAQLSPHEIRWRDRQVFLALKGYMLRPRYRPAWKPTWETDKSHHPNEFEDYYSLPPRDHLIDATRVNDGKLVYVKRVATGDTESQIIMKFSSPASRLDPRNHCVPVLDYFTDDEDSSISYIVMPFLRPVDYPPLETINDVVDFVSQLMEGLIFMHEQGVAHRDCSEKNLLMDADSLFPKGFHPVRMDNLPDGRRSATQLSRRAARVTYYYVDFGISVFIPPDKQPKLALGGYGRDQDVPELSFEVPYDPFKVDIFILGNTFRREIYEVGSAYCLVGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNL2</accession>
    <name>A0A2R6NNL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v10196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNL2"/>
    <dbReference type="STRING" id="98765.A0A2R6NNL2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR74012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64309" checksum="9E1105439AC0C6CF" modified="2018-06-20" version="1">MISPSLLDVVVVSAVLVFFAVFSDKGQRYWRSQYKLPPGPRGVPVFGNIFQVSALRPHPQFLQWAREYGEIFHLRLGPQTMIVLNTAEAADELFMNRSKNYSGRSAPHVGHDILSDGQRIVFLPYGKEWKAARKSVQAATGPGPSKRLRHIQDLESRTLLKDLLDYGDGHGRASQFCKPTEEVPEDHWFSLFRRYATSVVMMVTYGKRAHRIHDNPQLHKIYEVVANFVNVAQPGNYLADAFPIMRKLPDCLAPWRVKAREMHLWEMELWGGLLDEHKESTLKNGVSPDCYISSYLRSREEHGHAEATGSGITEDGWMRDKFLTYVAASVLEAGSDTTSSAALAFVLFMLSSPSALKKAREEIDTVVGDHRLPDFDDQVNLPYVVACVKETLRKHPPVPMGVPHRSEQDDIYKGSFIPKGSTVIGNVWAIHMDPVRYPNPTVFDPDRFYNKGCSTSWSSGPDAHDRDHYVFGWGRRFCQGALIAEASLFMICARIIWAFNFSTPKDPDGGCSLLPDADDEDGTWSDGFVRVPKTFPVVWNARSDSKAAMIRKISDDLQLEWQSMGLEPDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNM8</accession>
    <name>A0A2R6NNM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001032">
        <property type="protein sequence ID" value="PSR74033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNM8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6958" checksum="2552BC750D875DE5" modified="2018-06-20" version="1" fragment="single">IPSSAADYSSYLIWRLQDTLHNVVRFEKNAKIFKVRSAAAVADEFQIMFVASLPGEESRPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNN6</accession>
    <name>A0A2R6NNN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v10241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001047">
        <property type="protein sequence ID" value="PSR73934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNN6"/>
    <dbReference type="STRING" id="98765.A0A2R6NNN6"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR73934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="106" mass="11223" checksum="0C728E47CFAB9D87" modified="2018-06-20" version="1">MGASLFLYATITTPAASVGFNAMEYFFQSTFNAVLYGWTPEAFPAAVRGSACGLASFWGRLSSIIAPLIAARIEGSTGVLYLAGGGVFLCTLTALFLPDTRDREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP55</accession>
    <name>A0A2R6NP55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP55"/>
    <dbReference type="STRING" id="98765.A0A2R6NP55"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="185" mass="20743" checksum="79795D1DCF79C614" modified="2018-06-20" version="1">MASSNDVQRLFLQAVLSRRILSQQLAAKIWEKCIEAVKTVNQTLDIEFNDDRASWDDWVTKLNTSLNPLDLEFAHLFDETSGKDMYALVNRKGDQVAQMATEYTAAEIAYFKGVVRILPPLKSLVPPNLDCLQLEQIMLAPNESYCVSSLAALREVNSLKTNMTKTQAESVLGSFVAKGWLLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPH5</accession>
    <name>A0A2R6NPH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NPH5"/>
    <dbReference type="OrthoDB" id="2749714at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="430"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="666" mass="74261" checksum="5BCE71F19BA60B69" modified="2018-06-20" version="1">MRRQKDRFRSRMGTPRHRSPSPSHVHSRPGEYSASNRTRDTPGQAYHNREQSTSNYTAPTGPSTDIAVDTGDQRPQYASASKRINAQDVKDNEDRIVKVSSTGGVQVTSSTPHEINMTQSGNKTVISTGPRALTASLPLSQPVPPLIVAPTTFLSQINTTTTMTPSRATSFLVRPIEIGLAPCPAPPANSPPPIPTVPLPSNLADPTGLPATEANTSASGDNMIWPERIKLLSRAIAARSSIGDMENELRRYNELIASNHFGRFPDEAKAAVKKGFTNVKFRKMEKTKELQEATRRLTDLFPLCPQCCKQDFSIKAPTREPTPRQVETKPGVRIVTGELKDVVSQLHDAMQALNLHGKVSMPPLPHIQDAIRRDLLPREYNITSREFTPSKGSGGTDAASHSDMDIESVNEEGKDHPAQLAAIEGIHEYLLQLEDRISEMEDDSAQQEHDLMDEVDLRMEEKVKEMQESQEELRQDEQPVSILETDIQLTRTLRDIENELETSGNQVTELAQEVADLIMREGVILSENAKLKMENEELRRQQVETEARYKAELEAMRHDMQSIAASVKCYSEQAHKDAPECHPMANMYQDSAVEHLLPSLWPSIHEDVRSLTQETYQNIKKLVQTETDDTKQAVLPKVATAVRVTETIKAWMEATSKGTYPLVPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPS9</accession>
    <name>A0A2R6NPS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPS9"/>
    <dbReference type="STRING" id="98765.A0A2R6NPS9"/>
    <dbReference type="OrthoDB" id="2575061at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="869" mass="93819" checksum="811ED9A25A9ED754" modified="2018-06-20" version="1">MGMFNEPGPSSEPFYGGRKPTPRSVRIVSLQNSMAQAERDQHPRQRPLMLPLYLSSPAFNLAAMTSYTNFCFLYHIRLSAFAQEHGNLRDGLAETFYYYSQNLPTVALLLPRAALSLALLLAFWSPQAGELALADAGISPRDGTFFRASDQTLTNYARGVLIANAAWTAWRVLVLFLSWIGVWVFSGQGCAGICGPRYRWEEDDVEKTVSAFADNLSDTDVLPWSWRECTLLRVVDAYEFCLTNKHPRTAGEKKECTPSDSRGGTAPYEGMDKVFAAIGLGGGPQPARRGVLSDDLFASPEPEEEPEEPSHQATVALPAPAVQAREKHTSGPSGPLTKLPYPFVGHKAQVSSEDVIPFPPSPEPEEDREVPISDGVEGDEDEEEEQEGEEESEDAESEGRSEGRRTSGSMSSLGRPVSSSRYPFQFRKPPARGGSVSSASHMGPHQVSTPHSNQTRSTPSRSTQSRSTRHSQSTHSTGNRESSDSPYPQSSNAPSPLSISGSGIPMPPRHPQRRARAGTVPTSSIPSSPSPISFPGRQRVRARADSAQTGTESVGTDMSMTFGPLPLAYDLDNAEPPHDESLMDVPEAEGSIEEAEQHDSVGLLSAGTSPRASRTSLVNRLGGATHRRANGSRSRSGTGSRSNSRSRTNSSNSRSESARSRAQSLIQSLGAASRSSLELVRSRANSMARLSDSPYYSTSPDPIPSSPENNTFGHPLRTGWRTEGQREAQDDDHDISDTAELPSPSGSVPRSRASSGNVSVMGEENTVLRTARRRHMSEISRTAPSERHSEWSVQTARADVVPPSPSVPVDIPGRIVHTEQSMPDISTAAPSLVTAPATVEGTTDTSGRTPSSWGTVGRYLSGPERHEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPY0</accession>
    <name>A0A2R6NPY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPY0"/>
    <dbReference type="STRING" id="98765.A0A2R6NPY0"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF7">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="265"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="833"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="880"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="922"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR74179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1034" mass="112356" checksum="C4FE53E8779656BC" modified="2018-06-20" version="1">MKAFLNRINRGLSKDREKDTVHKEKIPQLPSLGDWPPSRTATTPVVSYKPLPEISGRPLPPIDEPTSSSTESSSVNPTPSGSIVPLPATNSTDDHVGVDGQGSATQTDSAGRSSHRTNNSNSTGAHTDIQKKVAFLSPPPTPGQLDRALPPTDTPTPANPVPLKTSVSRFQAAHVKDTRGSTSTAVSSKTDVTSTLKSHKPASTRAATSPYPKNHGDGASIHQSLRSATPYSQMTNASSRILAAQSWSEGAEEDLVSNIGQRERTRQEVLWEIVASEERYVNELLKMKETFIEPLLHPYSSSSPASPTAAGFDDYPVDSPRESIEYLPIASRFLSPTPFRSESPTGPAPSSHREDYLTPNIDGESLASDEEDEAEDRMGKGFPSSRKANHPRSPYGVTATRTAIGKYVTSVPFPSRSHQSLPPPPRSNLPTGSTQSLGRQSLHERDPNTASPKMSTTAPSSRVFRKFKKSNPSPTSSGVIVSGAVPPTQLPEDLRKCLEVIEGGILEGHIKLSEGLRKRYEEQYPLVRSLADVFVSNSHILHGYATFVLHLERALEQVDNALSSANATKKPKKQDADQWVKVCQYLQKLELLASEKGETGLAISLSKPFQRLLKYPLLFQNLLFHTDPSTFEYESTLQMVAEVETIVRSIEDEKIQKEERDKTRDVFARIEGLDKVKQLMVPKPSRVLLEERPAIGVNPMADVGMKLPPPPVSQNPKGVKGKTSFKRLSDVLQAGSSGIGGKKDQWLVVFNDVVLRCQRTGTTCLPLVAATNSRAASLPELQGKAKYATTGRRNSQGKPRNLYKFIKIETWAIGEVVQPREGVVSMEDVARSRQQVHSGIQPRIVPLPDDDEEGGGDSDDSDRKSKMSFSYWGADKVTLQKPVVKPRQPAGSGVRRGGGAATSYGRESSANAKFGNRLVSGETPNNARPASRRTQATPTNRRPGPSDEGHSVKATITRERPEWNTSTRNNLTPMPKKDGARTRNTSQGSAAASRTPPAATTTNKLASPAPSEDSGVGFYRTIIAQNPSLGRINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQU6</accession>
    <name>A0A2R6NQU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQU6"/>
    <dbReference type="STRING" id="98765.A0A2R6NQU6"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="434" mass="46399" checksum="B1395B2D03639426" modified="2018-06-20" version="1">MFEVMQDHFSREPPVYAKPKAPASPPPQGQPRRSDSTQPDYSARPPPPVPGTRPTSSPLSRSASILPGGNDDRPPLPVRPGMSSAFLPPDVSPATHPHLGIRAHPSSVIAPPALPGRPPPPLVPHDIADPGLPQYMLPSLPPQYAVHERSASPTAQLNLGPPANTRLVSNSPGPVVWSPSPGSMGEDISRSSIASYAVPGRIPSQSTNHFQTLSHPPPPPPLPVSSPEVTQPEPQALRPYLPPFLSPQSTGGAHTAHIHPPPPPPTLGYSQPVSAPAPVPRPPVSIPPPDLLDAEDDDSTLSVAPARAPAPPRPPNPELVRLHDQVHAKLSSELASLSQAMALDAERLRAHQTDLLAGEPAIRDEMARLEAVRDVCRGVSGRMRAVVEDAERNVAELKRKGDPDVDELVCSTTIVHNQLRRFIAFILWVVIERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQZ5</accession>
    <name>A0A2R6NQZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000939">
        <property type="protein sequence ID" value="PSR75026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQZ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NQZ5"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14488" checksum="111EAB4B65150463" modified="2018-06-20" version="1">MKKEDPNFVPPTSLHAKDTIARLGNGVIGGSEKRPREDRMDEDERESKREKTEEEDDGEEMEIEDDEESSAKGKNGFQSTQVVPSPQPNAAGQKCKMAQVLFDSPDLATVAKDALDGFTLKKGWVMSVAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRC9</accession>
    <name>A0A2R6NRC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRC9"/>
    <dbReference type="OrthoDB" id="2742096at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39245" checksum="C0E5173983E4DE0F" modified="2018-06-20" version="1">MVDFHVTFDPKPRVAGEVVEGEVLLNIPVLELRNYHEVHAECSCIVLTKIGNVKKSTTVFCSLAPIWKRSNLTKPSDEHITKVPFSFTLPSALLPTGKYIKKRSVGVVGYYIQVTGTRSGTLEANTHIFHYFPVLPSDARGFEISKSINEGWAGAWKTVEEKKSIRRYFWRRYATAVMTLSLPDLEFFPIATPTPFTLKIVTFTEPMQCKNPENGMNAISSLPDVPRDPRKEIEFNLVQTAFIDAGTKQTTITGHYGSKMFGFGAEADNLAKVETTQATWEPIKGDAKGRGTWKREVVFTSSFELFPFPSFQSTTLKVNVSGRSLIRNVPVCLHPGAVGDVYEGQVSWTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRE9</accession>
    <name>A0A2R6NRE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000910">
        <property type="protein sequence ID" value="PSR75262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRE9"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="721" mass="81396" checksum="47296DEFC885EFEB" modified="2018-06-20" version="1">MKVLNEDLDALLIFAGLFSAVLTAFVVPSYLLLQPDNSQLTVQLLVQISAQLARFEILPPFINSTASDASASPAFQVSTSARWMNCLWFLSLIFSLSSALFGILAKQWIREFLQWKKVAATPRENILLRQLRIEAWEDWKVSVGISAIPALLELAVVLFFTGLVVLVWTLDTVVAIVITAAVSVVILILCTVTVLPAVYRRCPYKSPTGWACVITVDALTLVIMWIGERLRWLLKCIEILLLFLFVFLAICPFYALGKIWQWNIQPAKELAIACLSRILRFNHDKRNSLPLFPRFSNWRDRDLYIDDLGSTEISNFNDVGLPHDRVLSAKICAAKDICEVIPLVRALSWVRKGTEDPHLLKHVAKLAGSLHTDGVCAEDRYYVLTYVLRKFHSAKSESRKLHSLSELENQIQLKAYDRVGREQMVFRGGIFSAYKYLDPPVGNLLDYSNVWVLGYLLIGDTMLKSSTHVHLCLLRHFLAVHDDNTFHTICRIQLQKIYNDAMSSQSDSHQKLRRCGLHTMVLEILCSVSEVRIVRGTGAISADRPRISADSIDNEIRLAIQMFDQNTGYSDHYARHQFVMMADLVIRSLDDCYVRNKDLMCALLQKMSEAVTISLEKGYQNCGCYHDLPWIGSMLSLSDWGLRFWMSSQPLWSLLDVLEKSLPTAGSNDENGDGGDDPGEGGNSGVCVPPFAKRRVVRENFFTLKEKVETLTLRPRTPGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRH1</accession>
    <name>A0A2R6NRH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRH1"/>
    <dbReference type="STRING" id="98765.A0A2R6NRH1"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="171" mass="18076" checksum="532C86C8CDD72070" modified="2018-06-20" version="1">MASSVLKGTRLAGKVCIITGAGSLHGIGRATAHRFAREGARHLYLVDLVADNFPTIQSSLHETNPDVKVTTIQADAADEEKIASICKMATNENGRLDVFFANAGKVVANSDSLEPYQTISAEQFMKCISNNTLSCFLALKHAADAMAKADESAGKLTGGGSIILTSSSMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRL4</accession>
    <name>A0A2R6NRL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9147</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRL4"/>
    <dbReference type="STRING" id="98765.A0A2R6NRL4"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="111"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="470" mass="52806" checksum="2CBB1E9617DCB320" modified="2018-06-20" version="1">MEDDDLIIVDDVEDTLPSTPEHSQAGPSHDPRPPPTGIRSALRRRDTLPSYASQMEDSDIRKTRSSTLRGFRPQPKLKLKLSEKAAAQAPGMSFLGPYDRELDSDDEDLVFEEQFILRMPPGEDCEKLKKMVATREIGNDVWFKFKDSRRAVFHLGNNTYSAKLVDLPCIIESQKTLDNKQMFKVADICQMLVVEQPIPGEDALANQKSFNIDEFIWPHGITPPLHHVRKRRFRKRINRRTIETVEQEVERLLEEDALADDVKYDVLENVNPDLSDSEFLDQEVTNDPQTPGYANSEVGDMPTPGAEADEHEGEEEAEEGDIDEDLAAELDLALGDGDEGDEGDDEEDEDEESEEEDEDDEDDDAVQAKKLLNEEIRDLEAAVGKKNSEIASSANPLIRRRFEDALRKLQADLDMKLAQRDELKEKRRLEKEGGTAEDVGAGSGDDEGEGGDGMDQEDLFGEDPDSMDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRR6</accession>
    <name>A0A2R6NRR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v9158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRR6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRR6"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015356326" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="180"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="520" mass="55068" checksum="7296F9CA0FCE2A12" modified="2018-06-20" version="1">MSSRVVAYGLMLLLAAGHVLVAQAQNQTFITGLLANLNGLGLTNLTNVMTQVQADANQIAFFLSLSDSSTPKTFFAPNNAAFQSPEVNFNGYPYQSDDTNFLGALLLYHLLPGTFLLADLGSGPNHTIVTTSLQGHSESFLENDESQVIACGSSVAGFEIYNQLTTTAVLSTTTFGHVTIHTLNAIIGMPGTYTFGENLLDISSFDSVRSSAGVQPIENSHGITIFAPEDGAFTNAKSQLSSTSPQAVFNNHVINGQTIWYSTFRSKTYTSASGHNYSFALTSDLGYTVTLNGVTANIIRSDFLLNNGVIHVLDAVLSNTTAEPTSAPAPPSASASNGGSKSDLSGGAIAGIVIGVVALLGGLLLAFLFWRRQHGEQHQTGYFDSPHPYPVHSSGVPFTTIPGDGMSEPANTPGVSAPLMYHASSDIESNDQPVHTQPYEMGEKGPPVNHQPDSGTTDFQSLMMTGRRSTDTYSPQSQQGRAGSSAPISDEVVDHLLQRFAQRIDRGPAGDPEAPPMYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRZ3</accession>
    <name>A0A2R6NRZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRZ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NRZ3"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="520"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="821" mass="92360" checksum="F0241947E73601C5" modified="2018-06-20" version="1">MDDSYYVVYKGAIHIFHHISRLHGIFSPYESLIIPMEFPDSNNHVAPSMDSAKDLSQRCQTLATIHENITRAQTIFRTNDQVMAVERPKLCECSLHLALVFSQVALQKTKKSSHRRHQRLHRQIQLLSERAKLPDFEKDLNQMVVMCREMLEHPLEGIQTLQLVQRYAESLLSRFDSFHNTADLEESIHLLQQYANNPAHELRDCRVMLCDARCKLFSSCGGADNLTLVISTIQHLLLASVWDNEWHNFDDDRLEKGRAFLAAIFRRQPAAQMDQQNRVALLEVYRGMVRLPYRMMEVGMDLHLGLPRLIRAQGLASEAFEHALLFSSPERAVEMLEKSRDVFWTQTLRLRSSFDALPPHIAERLKFVTLKLESYIHMMFGTNWEGDNNRYQQELHVLRRTQDEFQSLAEEARQVAGFEHFMADPETPFSSLAMAAQKGPVVILAAREMSTDAIIIRSPTSGAEHLVLGRMSFKRLSGLSLKLKVFNARSRNSQDDISHDSADDMSRSGRPAVRVGGGQLLNILWQEVVRPVINALGYQKAVGRDRPRLWWCPTGHFMSVPLHAAGDYSGDGDCCSDYVVTSYTRSLQSLSNARQGLESIITSDPKALLVAETNASNLIPLPNVAKEIAIVKSVIPSRAIISLGGKPESADSVEADHTSTRIQDAIEALPQASIVHFACHGTQRDAKDSVFHYASEALSSGFCFKDGTLKIQNFLRLGMPRAFFVFLSACESAKGDETQLDESVHMAAAMMFCGFRSVVATMWNMYDLDGPEVAKVIYAELFKGGPFNPDDIPYALDAAGQSMRTRGLPPSRWATYVRMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSB6</accession>
    <name>A0A2R6NSB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NSB6"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR75775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="380" mass="42928" checksum="E7552CD1E701F0C9" modified="2018-06-20" version="1">MSSNIIPDVPAPFSPLVKLQLPSPEEYNKRKVALISGITGQDGSYLTELLLEKGYEVHGIIRRSSSFNTSRLHHLYADQHERPNKLKLHHGDLSDSTNLVYIIAQVQPTEVYNLGAQSHVKVSFDMAEYTGDVDGLGTLRLLDAIRTCGLEKHVRFYQASTSELYGKVVETPQSETTPFYPRSPYGVAKLYSYWITVNYREAYGMFACNGILFNHESPRRGRTFVTRKITRAAAEISLGKQQCLYLGNMDAKRDWGHARDYVEGMWRMLQQPTAEDFVLATGETHPVREFVEKSFALLGMTIQWRGSGVQEEGVDSKTGKVLVRVDSQYFRPAEVELLLGNPAKAERILGWKRKVDFDSLVKEMVEADLKAAKSLVEDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT19</accession>
    <name>A0A2R6NT19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000860">
        <property type="protein sequence ID" value="PSR76147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT19"/>
    <dbReference type="STRING" id="98765.A0A2R6NT19"/>
    <dbReference type="OrthoDB" id="2499931at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="50"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="423" mass="46959" checksum="441F15987ADD1198" modified="2018-06-20" version="1">MTTCPTKTVLIDKHSAISAMKLMVDKYSIQFPTHKPCENPTSVHHDTLVITGTTGSLGAALLAELMVAPNVAHIYAINRKSQKPLLERQMEAFQRMGLANAVIQPSTNVTFIEANMQEENLGLEPEILHKIRKSATHIIHNAWPVNFNLSLQFFDQNVRSLRNLIDLALSSHHASPPRLIFISSVGVLRHACPSLPVKEGPVDPEIAVGSGYSESKWVAEKLLDEAASRSALRPLVVRVGQLSGSRSGAWKETEWFPSLIQSSVYLKCFPAVDKEISWLPTEDAARALVETKNTDVRYLHLAHPHPVNWSTIANPIATELDLPLVPYTEWLSLLTKSRKGLESKIEQEVVKVNSALKLLDFFTQISLAPESREMAMPRLDLSQARSNSPALNEVKPLSADIALKWISYWRHSGFLPLDSAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTM4</accession>
    <name>A0A2R6NTM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000843">
        <property type="protein sequence ID" value="PSR76461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTM4"/>
    <dbReference type="STRING" id="98765.A0A2R6NTM4"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="580" mass="65581" checksum="4FB3DAC4913B1D71" modified="2018-06-20" version="1">MEQIVVTAIVQNWCVTCPTQRQHLEDLCEGFNVRTREHAKSLARVCNRKYLWDTYGIINDILPFSDDLPHADIHELMAGDLLHQVIKGCFKEHLVDWVFAYIILEHGETVGHGIWGQIDRRLAAVPTFPGLRPFHQGRDFKQWTGDDSKGLMKIFLPAVVNFIPPDMTRAIKYFMEFCYLVRRSIQTEDTVARITHCLERYHHYRQIFVTTGVRPEGFSSLPLQHSAFHYPHHIRQFGAPNGLCSSITESKHIKAVKEPWRRSNKYNPLAQMLSTNQRTDKLAAARVDFTDRGMLQGSCLSDAMQAFLSLALGDDELDDSEDGESKEEQPSEGNAVEDGGDSEEDGAMEGPRVLGDVSLAKRPERAYPRTLPELGTHFGVPHLPSLVAFFLYDQTHSEPLPDGSPTPPCPPLQHIKVYHSAAATFYAPSDISGIGGMRRERIRATPSWFNGPARYDCVFAENDSTVEGFRGLHAARVRMFFSFECGGVEYPCALIHWYSPVADEPDDLTGLWVVEPDFDADNQPFYGVIHLDSIMRLAHLIPDFGDVVLPPDFHPSQSLDAFKTYYVNKYADHHAHEIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU57</accession>
    <name>A0A2R6NU57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NU57"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000148">
        <property type="entry name" value="protein RRP5 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="126"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="255"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="345"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="442"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="533"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="622"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="710"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="805"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="899"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1112"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR76702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1448" mass="161253" checksum="89B0A9B79B8C072F" modified="2018-06-20" version="1">MAPGVKRGLEDASGSPKPKKTKVDEKLHRANKSEKPPQVTSTLAPEDVDFPRGGGTSFTPLEVKAIRAEAVQEANMELFEDTQRKHTKKDKRSAGAQRKHKETTVKDGKAGTFRVEHLNYKRITVGMKILGQIVSVEPLALIVSLPNQLMAHVPITNISSQLTRLLESMDDDEPMESPDDDETERHNRVPELFEIFHPGQYVRAVVSAVHAQGSTNIPGLPRERGEAQKASRRIELSLVPEKVNEGVVKSDVKPGVTLSAAIKSVEDHGYILELGIPEVSGFLSFADMESTFTGSTKRLSVGHMLDVYVSKVSSNGRTCTVSLNPKYLRSTLLTEVSSVTSVLPGCLVQGLITAVLPTGLNLQVLGFFNGSVDQFHLPPGDVEENYKLGKKVQARVLYDISPSTPPRFALSLAKHVVSLTSKFVNRSDDDKEATIQEAFPIGTILDTVEVVRVESERGLIVRISSAVEGVVHISQVSDDHVATLSPNSGPWKIGTMHRARVTGYHPLDGLLQLSLQSSVLDQRFLQVSEVQVGEVIKGTVKRLTDSAMFVSISGNVDGVVWPNHYADIALKHPQKRFKPGGSIKCRILVVDPERKRVVLTAKKTLIESKLPIISNLEDAKEGLLTHAVVFKTSDKSLQVEFYNNLKAIIPIREASETAIRSLSEAFPVGKVVQVRILSVDRETSRIVASIRQAAANFKIALTAIQDIEIGNVAEGIVAEVQKDKVIVTLQPSQVRALLSLNNLANRRGTTLAQVRTSLQVGEKIENLVVTSRNPEKGFVLVATKPKEKDALLLKHSLTLDTVQVGQLVGGRILRHNRHGALVKLTPHVSGSLHPTDTCDDFETGNPFPSADSIIKATVISIDKDKRQLTLSTRPSRLHPERESPVIDKEINDFSEVQVGATVRGFIKTVAEHGLFVTLGRGIDARVQIKELFDAYVKDWKSHFTANKLVKGRILSVDTEKKQVEMTFKTGELSRNNMSSLQLADMREGQKVDGTVKKIEDYGLFIEIEGSKLRGLCHKSELSDNKDADVSMALRSFREGDRVKAMVLSVDLDKRRLSLGLKPSYFAEEDFQPEANEDDEDEDEPLGVVEQDEIPSDVLEEREDESSEDEDMHVDLDTEISRSVFDDNAKQNKAHPISRTEGLKLGNGFQWSADHLSDDSNSESSESEGEDVGQTERKKKRRRKEIEQDLTADLHTKVPESNADFERLLLGSPNSSYLWIQYMSFQLQLSEVEKARELARRALKTINFREEHEKLNVWIALLNLENVYGSDESLETTFKDAARHNDSKTVHLRLAAIFDDSEQPEKAEEQYKRTCKKFGQSSKVWTLFGEHYLKHGKPEEARNLLPRSLQSLDQRKHLKTISKFAQLEYKSGDPERGKTIFEGIVDSHPKRWDLWSIYLDMEVNQGDIASLRSFFKKWLELERRLGDDEGASIVKAKAIEWTQRAATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUG1</accession>
    <name>A0A2R6NUG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000833">
        <property type="protein sequence ID" value="PSR76850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUG1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34490" checksum="28C3EBF9EC3AD7E0" modified="2018-06-20" version="1">MPKALGSFLAPFSSLKKLCLHDYRFHSISDLLRLCSKLRELITLQVERLTWANVPRELPWLPRTGHRLRCLETFDCAANWPFLWIWAGPKLGSISASEENFPGLTYDDARVVGEIGRLCVPHLMPQDVRIECRASFSPPGWIITVHSMYLGTQVIQLHTRSYGSLAVVTQIIFVNLSPSTARSSLDSTGLNEQLTRLPYLETVIFDDDDGFTTQGPYIQPEVLQEYRALFPGLQDKLTLDQGGLRIFGKAARVAWRRTIIPDTYPRTAIEWPGEDFMQDKKSKPLISIPSHIKLTDPEVTPSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVR1</accession>
    <name>A0A2R6NVR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v7703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000776">
        <property type="protein sequence ID" value="PSR77780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVR1"/>
    <dbReference type="STRING" id="98765.A0A2R6NVR1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR77780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="360" mass="38281" checksum="D7ADBB2B2ED0F5D1" modified="2018-06-20" version="1">MSTFEPIPKTMKAAVIPSTGASLVIRDDEPVPQPEDLLPGECLVKMDCTGVCHTDLHAAKGDWPIPAKTPLIGGHEGVGIVVAIGAHTQDSPVKLGDRVGIKWLADSCLDCESCRKGLEQVCLKGKYSGFTVDGTFSEYVHSYVRHVTPIPDGIGSAEAASILCAGVTVYRAIKYSHCSIGDWIVLPGAGGGLGHLAVQYASAMGLRVLAIDTGADKRDLVMKLGAEKWIDFKETKDLVKDIQDATDGLGPHAAVITAATGKAYEQAIDYLRPGGYLMAVGLPAKASLSADIFFTVTKSISILGSYVGNRQDAREALDIAARGKVKCYFSTKSLSALKETYEGLEKGNIVGRIVLDFKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWB4</accession>
    <name>A0A2R6NWB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heme oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWB4"/>
    <dbReference type="STRING" id="98765.A0A2R6NWB4"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR78198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37398" checksum="0C1297EDAF413354" modified="2018-06-20" version="1">MTSVSTATEVDWSQPVAALLRIGTAQAHEKAEHSEGAAWLTRGELDREEYVRFLMMLYHVYETFERALDRHATHLVLAPTYNPTLFSRTPSLSADIAYLLETPESSWQSHPIHETLVSSPPEPFADYTARLQELADNESQVPRLLAHAYVRYLGDLSGGQFIKRRLVKAYGLEDGAGVSFYEFKQLGGSGSSTMGDMKKIKEWYRAGMNAGVGDDVALKAAILDEANVAFDLNSGLFTTLKPPSEPPMPSSPMPDIMLGEPLTPTTDSPTPKELTPEPAVTKVVYEAPSQEGTFPVASVIAFILALCLSHFVLVLGGFTGDKGYGKLEAVIHWFADLFSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX47</accession>
    <name>A0A2R6NX47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX47"/>
    <dbReference type="STRING" id="98765.A0A2R6NX47"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="112" mass="12691" checksum="A9D0E6C1F0E5981B" modified="2018-06-20" version="1">MSNKGRTTPRIVCCAIPIARAAGKILLITSRKRPDNWVSGVRGKITRFVTTIPSASSTYHFYELDVADLDQDWLESKERRREWVDYAEALKRLAWKAELAQGLSLSSVAPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXG4</accession>
    <name>A0A2R6NXG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXG4"/>
    <dbReference type="STRING" id="98765.A0A2R6NXG4"/>
    <dbReference type="OrthoDB" id="2499463at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="12440" checksum="E70DBF342B51168A" modified="2018-06-20" version="1">MAVHAKHAQTGRLSYSAHTQFSASDNAQWPRRRLTQKEVGCLTLRMRTEYGWKADPKPFQLAGVQAQLEGVDMIIQASTGAGKTAIAAGPHLWKQGMVSIMVCPLMTLEDEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY91</accession>
    <name>A0A2R6NY91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>melleolide F + FADH2 + chloride + O2 = 6'-chloromelleolide F + FAD + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:167712"/>
            <dbReference type="ChEBI" id="CHEBI:167713"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:67161"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000696">
        <property type="protein sequence ID" value="PSR79400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY91"/>
    <dbReference type="STRING" id="98765.A0A2R6NY91"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140907">
        <property type="term" value="F:flavin-dependent halogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="255" mass="28208" checksum="E39CBD85F68DD6B5" modified="2018-06-20" version="1">MTGTSRENAVWIEALNDESGWVWFIPLHDGSTSVGVVMDKDIASRKKKPYTVEGQDERLHAFYMDELQRAPGVIKLLGEGALQSRPGEKVIKTTGDFSYSAGKYAGDYYRIAGDAGAFIDPFFSSGVHLALTGALSAALTIAASIRGTVSEAKAGRWHDSKVGTAYTRFLIVVLGTYKQIRNQNTAIMSDINEDNFDRAFELLRPDDFEAKAVLLEVNARKPIHTMYNPKQNFTNEIHHGLNANIQRGYLDLTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYA6</accession>
    <name>A0A2R6NYA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYA6"/>
    <dbReference type="STRING" id="98765.A0A2R6NYA6"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="616" mass="70677" checksum="E28BC8AA68FFDCFE" modified="2018-06-20" version="1">MFPYSYNPYASPYLYGPPSQNHSDLEYRRALAEEQAARQAYADACRAQEDARSRAARARLARQAYDSAYGAPHSSYLSDEDEEVDAHIDYGYGNTPRGYGYNSSRQRAEQQRREFEQQRKREVLQMERARDERLFEERRKRLLEEERVRMAMLEEEERRRRREAEARRIKEQERIRMLEEEHFRRQQPELSPFEELFDMRPSRFASNEPPNSRRARTASSVHRNPEARSSKQAPNPNHTVKPAQAAPQSQRVTISSSRPSTPSPNSRQHTPSRSRADIPISVPSTPPSPSRSTLRLSPERHAAAEKIQSFWRRHGPRRLALRTISELNNTFDSLKATFSLPCTLEYQVTVAQGPTNSVISVPTDGFREPSNSEDIMQIDIDSLPKIPKLAYTPTNTPVHMYEEQLSRILTRLDDVQSGGDKEVRRKRRELARKVETEAERIEWVKMEVWKAWDAKQHQGEINHEQNGSAQSLQEQTMEEGREKEETEKQCDYKEWENEDKQIYEKQVTNGETNDQAITAEKSGKSESDEPQEVEFTATRTMEVEPSSSPARPASARTNKTATQPEAEVEVDIDATKEALGDTVHIEAQPGFPCFPKVPASYTPPFALVSSSTPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYB8</accession>
    <name>A0A2R6NYB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000678">
        <property type="protein sequence ID" value="PSR79947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYB8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="121" mass="13621" checksum="8616F3DCC71B2F99" modified="2018-06-20" version="1">MSLVAPSIDSHRIPEGYAPLFRKLINVVKDIEEGGLIVEEQKRRGREQRLPRDEVTMVVLHQCTFPNRAQIDLTTTLQHLSTAHSFLIIRIGHGILLVGMTCLDCDASSNLTRRGPPVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYF2</accession>
    <name>A0A2R6NYF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000666">
        <property type="protein sequence ID" value="PSR80152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYF2"/>
    <dbReference type="STRING" id="98765.A0A2R6NYF2"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="261" mass="27645" checksum="4E92E21DCB500D71" modified="2018-06-20" version="1" fragment="single">LDLPDTVQMTNAGTGPYNGSLLLVNSGRGPLPPNLVLVDPANPQNATVILDNFFGRQFNSLHNAKIHPTSGNIFFTDVAYGWLNHFRPLPLLPNQLYRFDPNSGSVRAVADGFVLPNGLAFSQDGSTVFVSDSGMAGGFIGNNQTGPATIYAFDVDPQTESFGNKRVFSYIDGGVPHGLQLDTAGNLYAGTGDGVEVWNSQGTLIGKFFLGSSSSEMLFIGNGRLIILAETKIYMVSLAAEGLDVDYPQGSSSVSEDPSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0P2</accession>
    <name>A0A2R6P0P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0P2"/>
    <dbReference type="STRING" id="98765.A0A2R6P0P2"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10887" checksum="8A7B32275496A3AB" modified="2018-06-20" version="1">MESNVSTKRKFPPLYTSSGDTAADRLAFFHILERLKTFPTFEYEKNHQMKTLQPFFDSSLPKIRHPEVRQWGEDLLVEREQLQRASSTASQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1I1</accession>
    <name>A0A2R6P1I1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1I1"/>
    <dbReference type="STRING" id="98765.A0A2R6P1I1"/>
    <dbReference type="OrthoDB" id="3245306at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF3">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="985" mass="107075" checksum="CC5FFF904491D51F" modified="2018-06-20" version="1">MASSAPNTPATGSSSGPRPASPSPSRSGFRTLARVGTMLRRNSSGFGFGRQSVSRSESKSSLKAAAAAQAAAEDNLPSPVPESPAREAAEVAAESSHHAHVGPSPLAHETTTSPEPSPTPIPAQLIAEPEPLAETAPVVTEPAPSPPVTIPEPSVTAPASQPASAPAPVPAPAPAPAPAPETTAPAELEAPVQPPSEPVVVSPKDEQVISRDKQIFNPEEFRHEEPYSPPVPIESRGSDYFAWGDPIVAKKASVSTMQTQRSVSVPVAEVSAPVAESSQPKVQEVPKDPYTSSAADSFAWKDEALVPVVKRSDSSIPKITSQEHLVGSPQNVSRPLSHEQLVASPHSIARSLSPRNSRSSIASSYGNIVNVSTGSRRVSVSLDPNTEQMRGRSRSRASIRVSFDDPYTDPFADPPNSNQMEVPKHTLSPIYSINTPMYEESVPIFQSTQDTTRQMPEPMHAEPAHYEEETVLHEATPAPVSMPLPALNEVTTRGVRQQPSGYSIGTSSGIVDHAPHAPYETNERLPLLPRMPTPNLNVGSSKAPAEPSFNDINVGVPPTDGVAWPMIERSFKSLGWTEHILPDSSVYYAHHNMRVVTDIDLRNARKLDAVTDYFDKKQPRETLLPPPSWELWLRDVSKTRYESSLVKCWVNHEGRILTFETPASFTIGESSTVTDDDKLDMEYRYWTYMEGHPAHAPLPDNAHAEAINTLTWCYTDYLLPSQQPTPAPFSPQECQELMGLLKAFDNNSNRIEVVHIRVVSRVLLRFAQWRQQNFRPNKPLPNDTSRSIQPERRRPYRRAFMDVIMSILCLGIPYLFMGRSSPHRVDEEGAVRSHGPIVVIGACACLIAAVILSASVTFLSLPGLDDISRLAGMIAILFSASSMVSAVVALFRYKADLERTVVYVGGEGLMVVSQRSIVMSLPVVFLAWGIAAFITGITFYSFRGASFTSKVVIRQPFTDYTHWAVVGGLGGLTGMLIVSILLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Q9</accession>
    <name>A0A2R6P1Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Q9"/>
    <dbReference type="STRING" id="98765.A0A2R6P1Q9"/>
    <dbReference type="OrthoDB" id="10508479at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="14003" checksum="C3423812687C9C59" modified="2018-06-20" version="1">MYTTYTDTPDTPRLSNIANALYTSIPSYTTSDHKPVVSVLLLPPPLPNTSSTPHVLKLPTTYTPHPDPYTPLKKYTGRVLDRSIGYCWWLLTVFGAGSAVFGIGNFILSLGMWGWWKTRPSGTSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1X9</accession>
    <name>A0A2R6P1X9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v5571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1X9"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000368">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="43139" checksum="43E379DF13AF4BF9" modified="2018-06-20" version="1">MAHVKFPGIEEDLTASNTPWIYYGGSYAGARAAHMRVLYPDLVFGAIASSAVTHASIENWEYMEIIRNAADPKCSAHLEKSIKTIDSLLAVPRLKRQLKGLFGLADLEHDEDFASLIESPLGSWQAKNWNPEVGSTRWEEFCEALDKPIFGHPDLLLNTTAFYDHDTKMVTFPGGLEVDLSVLNYARYIRENYVSRCPIADGATVEQCFGTYEDSQFQGISLDETWRLWVFQVCTEWGYFSTAPPEGHPRIVSNLLTLDYESKICRQAFPAGKHFKVPHLPNVTAVNVLGDFDIEADRLAIIDGEVDPWKPCTPHSEYARDRKDTINKPFKLIPGGVHHYDENGLRRRSDEPPQIRKIHEEIVEFVTEWLKDWKAPDVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8S2</accession>
    <name>A0A2R6P8S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8S2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="154" mass="16694" checksum="06BE6CDC592978F2" modified="2018-06-20" version="1">MLPLVVKTEVMTIVVRIVVTSAGEVVFVDITELLAGELVMGRNGRVVTVNVDKSREFDREVGVTNEDKVVDDGVEGAAEVIVGGEIEKDVVVDDDVAGDEDEVEADVSDREEVIAEDEKVTVEEVTETDEKVEDEGTVVLDDDDKAGEEIEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBS8</accession>
    <name>A0A2R6PBS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000512">
        <property type="protein sequence ID" value="PSR88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBS8"/>
    <dbReference type="STRING" id="98765.A0A2R6PBS8"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="2">
        <location>
            <begin position="527"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="620" mass="68237" checksum="F39E050B42AF05EB" modified="2018-06-20" version="1">MSDTQSVSMEAAQITGVNSGYAQKRKQHLALINQLRAIGAQADLDLPRIAVIGNQSAGKSSLVEAISGPDDDERAKGITTMQARAAEKDFFANTKPWCASSRKRQFGTSNLVESLSKLLTHIIDDALPKLKSEVASQLETCNDELNKLPPAITADPSSFVLTLVSEFCNEVKLRIKGGDTRASTLIQANHKAYATYKRDIRHAAPPFLPFPSSEEADPDVHQYLRLDEDGEATAFTPLSGISSGALYLNDVREHIRRSRARELPNNVPYAAKVALIDGFQSSWEMDSRTCFAVIFATFENALLQLISQQFQRYDTLRSSITYAVRELLRSKHEDTWTNVEMILNLEKAMPYTQNSHYLQVTKDKNLSLYKAARAEARDNSDGPPTKRPRIETRTATASTAQTSPLASGRDYPMPINGGRASPTTPIAISKKQPVASASKQTTPATGLDKFTFSQPPTEKIVGVSPANSPAIAASSTCFSEQGPKRGLDDEDQKKHQKLALSSLAALGIHVTVADLGKLHPPDIYEEELEVMAEVRAYFQVAYKRVIDYVPMVIDKTFLFAFAESLQGCLIEKLGLGMPNSTTRCATYLSEEPDVVARRDELTSKKARLQTIQTELFNFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBV0</accession>
    <name>A0A2R6PBV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBV0"/>
    <dbReference type="OrthoDB" id="2790304at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="158" mass="17757" checksum="0A6D0B9C87FCF205" modified="2018-06-20" version="1">MPLDDAGMRRLGHAFVYRIIPVLAATILYGIYIALLFQATHGLRYVISIPVPPATPLTLFSRERGLLKSRANSMILFILYFLFLLTTTLWALEVAQLFGLNQILFHPNDLSTDSKFNSFYDLIASETRVTGILFETQVSVSIGDSEESTQPVVSDDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBV7</accession>
    <name>A0A2R6PBV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBV7"/>
    <dbReference type="STRING" id="98765.A0A2R6PBV7"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="15530" checksum="1626F40132734249" modified="2018-06-20" version="1">MDISFASIERTVLVKTKKRIAQATFFLSQPPTFYLEDEVASTVNSAVGTSVLRCWTQCHDWTENNEGSTVLQHEVLGPYIPLNYLLKNIILARPSSCPVKDEAIEPSGILNSAPAPSILGPSDETMSALPLPSCFAAVRQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBY3</accession>
    <name>A0A2R6PBY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5098</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBY3"/>
    <dbReference type="STRING" id="98765.A0A2R6PBY3"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR88747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="272" mass="31257" checksum="64C47A7EFB8E1DB9" modified="2018-06-20" version="1">MSIRCWDELVKYGVDQVLQREYGHRVKAQPESEYNVSLELDLEQFPPEGEERDSLIKSISLLKRNALAAPFELAFSTQKQLSASGTGHGELLALHYRDEEAIYVQASSDRVTVIFSTIFREETDRIFGKVFLQNTAFREPISHLACQEFVDARRLPTIQSAPQVLYSTRDAPLELSHLPGLKQTEDVGYVTFVLFPRHFANPEVAGSTISHIQNFRDYLHYHIKCSKAYMHSRMRHRVTEFQKVLNRAKTEVAVTDRKTARYVPLPPIPQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PJD6</accession>
    <name>A0A2R6PJD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000479">
        <property type="protein sequence ID" value="PSR92237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PJD6"/>
    <dbReference type="STRING" id="98765.A0A2R6PJD6"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR92237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="497" mass="54683" checksum="0F63B7953C55AD10" modified="2018-06-20" version="1">MVAPKMRRRIGLEWASSTNISSNRTRRNIIIVRRIENCPILAAFDSSSYGIIAAQPYGYPQPIVPPQIPFPSGYPAFNGAPVVPPVPPAFTNQPAFNSEPVVPQVPFPEPERGAPVVPSHPGRDVEDMRVPIDPGQYGPRPSLFQRPKSLHFRRNPLPEPPRDVFESSPYVSLLRELRRDPEEKLHRSATLPHANGYIVTPPGQQYGSHSSRGHKERKGIFRSLSNAFGSKSRREPNRAGIPIVQPVVFAGPPMVQRTPIGTNFVYNTTPAQPPMAIPAQGTPASRMRSPVPSANVYRRDPSPAPSVPMYQRASSPAPSAHKYQRASSPAPSAHMYQRAPSPAQNAAMYQRASSPAQNAQTYQRGPSPAPLERARSPRVQRIDLSNEFAGLVHLSPHPITYDGKRYPSAFHLLEAMRFMEGSPDIAERVRNCGTVDEVRAVVHQASSLIRPDWEHIVVAKAPQIYCIPIPGTISGVMDLLDAEQTSLAEPSDMCESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMU8</accession>
    <name>A0A2R6PMU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMU8"/>
    <dbReference type="STRING" id="98765.A0A2R6PMU8"/>
    <dbReference type="OrthoDB" id="2803889at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="654" mass="72346" checksum="37B8522FFA483F93" modified="2018-06-20" version="1">MSEPKDIDMNASGLSTPNNILPGGSGPSVNDGVVAQAMSSDPPVSYLPSEHNASNPMTDLVDAIDGMYRILDLMSEQGSGGLIDKIIIAQESFGRFVNDTCPGAYQSMTQVKFDALDALSIKPLGIYGSKEEIARYLRDVGAVSEAIALSLLGNKVDASRSMSSGQRILRSGLYLLRDAAQDLVYAIYWPEDSTWDDDAVSSVQRNRVTFMRYLTKITDQVVALISEKHANSIVWAEESQDASMDVDTDDESDRLFTFQVAKTHEQEENVQCRTGFKIHDMKINNPLTADDPSIDPATLAPRLVQGEGAIGFMNSTYIPAHEALRQINEIQAPFALRQFIERASFRLSDSLSESAFDILLKYDLGRRVPAAFETLKGHRRSVNQASQVAWKNKEGEINKELNAGNPLLVAALSKEMADVIVRNFSPLSHDRLLDSKCREADQSQCSELLSNLCGIYPPLGTWRHESISDSKLQSISKKTFTNLKEKLLAMQDAFDSQPDLSEADQRGLVDSIMADNTTRTREGRPQAGIVSRLVGAVKYSLAPSPVFGSQDHQDIQRERVSNVQFLCNLPSLLDKYPILSDIAGDAVNIAHEHFSAQIKTLANKTAQRLEDLRRSEFMKSLELQLEHDKKISLDTSRATFLNNIGDSLVREKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN12</accession>
    <name>A0A2R6PN12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DM34 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN12"/>
    <dbReference type="STRING" id="98765.A0A2R6PN12"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="DM34" evidence="5">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR93815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="676" mass="74034" checksum="C2FE013CCA84DD47" modified="2018-06-20" version="1">MSFTFKWPRFSDQFHADAIQMLDAALNKGNKPPVIADKIEVVELEMGTQANPLNHKQPDIHIMGGSRGMLAAKKPLVVPMLLRLSHFKLNSYVVLVVSKQKGITLVFKTDPLQNVDINSTFDSIAVIQKFIQHEIEGQLRQMFREDLPGIIHRLSQQWVKAKVEAPYLDKRSPAARSESGAFSAYNAHLHRLPPRLPPVGVRPTLARTSSLASGTGRAQSATGLSTSSVGLKAFSTVSAPTSDNGPPAHEGPTTFPDLENFDPTYGLRPDGLPTKSVFNNLRSLFSPNKGLAELAEETSEHEEDDVGSFDIGTWEDLISDAPPSTCSPSEIGQIEEYETVPAVGGGTITRPRIIHSHSQILSPAGDLPRLPSRTPSRPVTASGLTASRLSNLESMNNQIRSKGSGGSRGLASMLERQNSWGGQYNPYFAGTTPMYSPSTSDLDEHPEDYSPYQSRIDSRYATPFSPSITPVPPFRHFPSRTGSPSSAYTHTSPSSGTHSIPTPTNPGSEDGGIPLNRVRRSSFTSSANLDRFGSPPDHLYLSGSDHDPKVMLKPGLNSVSRLTSLSHSNHTLSPYTRTLEHFTVRSVPPRENTPSGSASASERQPVKARRKRTFYLGQKPTLKEEERRPVRSSSPLPSSSDFDASDMDRYFRSGDDIVSQYADIHLSHVRRRSHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PP72</accession>
    <name>A0A2R6PP72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PP72"/>
    <dbReference type="STRING" id="98765.A0A2R6PP72"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR94131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="17746" checksum="A549CCAD291FEE0B" modified="2018-06-20" version="1">MSNVFFDFIINDEPAGRIVFKLFGDVVPKTARNFRELATGQNGFGYKGSVFHRVIPSFVLQGGDFTRGNNTGGKSIYGETFADENFQLKHTKPYLLSMVNAGKDTNGSQFFIPTTATPWLDRKHVVFGEVVEGFALVEQIEHLGTATGVPKARITIANAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PPA9</accession>
    <name>A0A2R6PPA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000448">
        <property type="protein sequence ID" value="PSR94546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PPA9"/>
    <dbReference type="STRING" id="98765.A0A2R6PPA9"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="863" mass="97673" checksum="A39992527750FBB6" modified="2018-06-20" version="1" fragment="single">PVTYQREAEELKKLRKRQRRDAIAAEAVLANQVIDDAPSIELEVELPPPEFVPPASTFSELQPSGRRPWIHRAPKRVADYLPSSLTSLRGLPKYFQPPPQPQSPALPQLDDVTPMPTIAPSDETDSSTKYICGKANAFDLYRAYLEPPTLDPEAALSLDTACDTPTLATAKSDRPPWWSVFGKCTVPSLKETHFTPFLNATAFRLMSLFYSGSSMKSIGELDRLVNEVILSDDFDRAELCGFSASREAHRLDEWIDESSSASKDFQVEDGWHEGTVKISVPCKRTKWCLEQAAPIFEVPGVFYRKFIDILKTTLSSTTAKTFHMTPFKLFLRPPESTAESPPERVYSELYNSDAMNDEYEKIKSVPRTDDYWYLETFGKTASAAVLTHCKRELMHAIWELLLDDDFMHAYEHGIVIEFADGISRRVFPRIFTYSADYLEKVLLATIRYLATCPCPRCLVQKKEISAIGTKMDTKRRERKARADNHNRRRVINLTRTWIYEKGLNITSKYLNNVLAARSWVPTCNAFSTKLSKFGLNFFSMLAVDLLHEFELGVWKAIFTHLMCILYAAGGDLIQNLNTRYRTVPTFGRGVIQQFVKNTSAMKKLAARDWEDMLQVAIPVFEGLLEKPYNSIVLDLLFTLATWRALAKLCLPADSTISILEKTTTNLGILLRQFAATAARGRRTAAKTGQSKGKGRATKGQSQADTIAETAGSTAGARLKKFSLATYKLHALGDYSTMVRAFGTTDSYSTQTGELEHRHIKRFYARTNKQNFTQQITRQHMREELIRRVKKRVEKKESEDKDKTILPNKPSVSSDCATLSFAESDPLPYTPPKKHDHISQSNRFHQDLNDWLNSNNGDPTLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVK3</accession>
    <name>A0A2R6PVK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000436">
        <property type="protein sequence ID" value="PSR97466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVK3"/>
    <dbReference type="OrthoDB" id="2754197at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="373" mass="42665" checksum="7C9436E52D03775A" modified="2018-06-20" version="1">MSADAGNRYNHLRVLAIDIAFFQQEQCKHMFINVLRRAHKLEDLSVLDSDLLTTDTRFTTVIAKLTSLKVFTLAHYGSEDFEPATMLYLMRSKLVKATIDFCKFEDPIDILANSASSLEELEAVHVYFEREDVQYPKMKTLSLELWRVADIGPLIHAYPNLCTLEIQGYSANESYFDNAVVDRATNQAFQLQRSWKTLDSVHANIVELYALAINCKIHSLNVADGLYNIQHIEMLCAILADCRPSNLRIHCNGFKTDRFPDIPRSIPSELVEVDLWVDLEELSTSDELDRFLVPDFSDLIQFLTNWNADDEGGPLPEPLLERHAMEPILRDLNMNALAHRIMSTIPSLQSLYLLVSFHEGGRIYGRAPREEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ75</accession>
    <name>A0A2R6PZ75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000418">
        <property type="protein sequence ID" value="PSR99455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ75"/>
    <dbReference type="STRING" id="98765.A0A2R6PZ75"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="756"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR99455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1140" mass="129644" checksum="6ED918EBBAE0B84E" modified="2018-06-20" version="1" fragment="single">TSAYIRRSLHFTDDMSAPPQWSLTAFDTALEAHIKSLTKHEKRLIEGSQPDFVTIRQNIEAMDHRHKRSHTRRFLSSIGTIYNHFDTFFDFLKDALSAAPFYVGLIFRSITYIMQLAETFVQYFGQISTNLEVISQALASFETYDKVLFTNWTRVKQALVNIYSSIFQYFTQAIRVFKRPNGESRCPLEIAWRTTILPDKSLDEIMQHFQQFRKNLNGEVKVAEQRRQRILEFAHTLGLFEYKARYEELRETPNMQPGAWLFELPQFASWLNGNNGQTVKLLWCYGTEGCGKSVLCSNVIKHLDTISNFKGQMIAYAYFFCGRDEKREQAALTIMRCILLQFINRLYDLDPSWLADVILQSDTIPQLLSRTDVRNYIIRIAPLLGKIFIVVDGLNRLSRGAMKQVASDLCNLIHGAGNLRVIVFTRDRQYIRDAFEPCYSYNAGITGRIECTRYSAPGVKRFIKLELMRRTFQLDVIRQYVEDSVEKYANGIYLKAKLTIDDICHERSGDFAPLQKLRHLSYNGRQGMYRKSMAYINGLDEERSARAGAVLDWVLLAACPLTPEELAHAIAVGEMMGSDVWLPELVPDSDELLKDCAGLCVQRRGKVVIADSSVADFIAAALSNKYTQNLHDVERERHYELFQRCLQYQKLYAQMDPPNGITRGCFSSYVYWHSFHHCHRAGLVIEAGLDVHDADSLYHGPYQNCVHNAAQRLPELPVKASDAPLPSGGRLQRILQPLLTTARPVSQEQSEDRNESQDEYAYRWFLALDVDFSGTIDPSELSGVLGARLDPADDKMLGAGPRSDSRPFIVPATTLLEADTVKALMSRFADAHHDYLSLPQFTGLIQFSMKYIIQFRRIDSINRGLIAGAEFLQTIKEQGFSIETSVGKLQYMAISLDSFVRSFVELHEIRDTYPVRDGDPSIVPLQPDQLMRICVTAKILPLWDTSILPHTTARVDQDPEHYAALHMSPGHLDVTGGAPSPPDLHREHHRIISPSYHDFTVGAPSPPDKEHHRIMSPIYLDVRDGAPSPVRVPDSPPDLHREQYRIISPSYHDFTVGAPSPLDKEHYRIMSPSYADVRAGAPSLVRVPDSPPNFRREDHRIVSPSYPDVTLDAPPLVQNISEDFLPDDYIPSKIATSIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7F8</accession>
    <name>A0A2R6Q7F8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000388">
        <property type="protein sequence ID" value="PSS03317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7F8"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7F8"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="470"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS03317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="677" mass="76733" checksum="31DED9A9D52D033F" modified="2018-06-20" version="1">MRDGMSQIGDSPGPRSFGMSPVAYPRVRSQRSIVSPALEKATGKTSQALSSYDLSKLELGVNHIRSKWDRSKNCYVIELDSSQEDNDGEDGPPTYPPTHAFTVFRTFTPTDNPLVFSISKKIHVWSPYFVEVAKAVMGDWTNISWNAKPVVLDPKDVLIFLPKFKRHLHLLQSEPEAAVAIHLAYFLEFIEKEYENTLATLHNLLEERKISFELFWGLFLPGTILITHCRTTGEPLVVRLRSCVRQSASFNEPPHWLLTCEYVDVDKGLPGYAELAVKIHDFPGAEVITDLHIFPMDPYVEEPRRSELCETLMRRGRRRWELSRSWSHNDHDAIAYAARGGGKMNVKCRIVLDQEKYIQYAYGDPLPTVKRDLDGKLVGLKVLSTKADARRVDMTAEEFLLMPAKLYGFSLGDRKWLIFNVDNVQDIRWNLEAFERLDIPENKKVIVQTLIESHTQKAATFDDFVPGKGLGLIFALHGPPGVGKTLTAEATSEVARSPLYMVGAGDLGTSAQELDRALTTLFALASAWKAIVLIDEADVFLEKRDVHDLVRNSMVAVFLRQLEYYTGNLILTTNRLETIDHAMKSRIHVSLRYEPLNMETRERLWQAFLKKAGLQSYEGNIVDAELMRELCQRPLNGREIKNIIKTATIFASYHGRAVDVQDVLRVVHTTDDLSAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7I9</accession>
    <name>A0A2R6Q7I9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000383">
        <property type="protein sequence ID" value="PSS03706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7I9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="36763" checksum="7E16BF79D6170928" modified="2018-06-20" version="1">MFKCPATGLLSPRPFRKLHLLQFTSVDLSEDTTKEVLDIIGHLIHIERLEISFPYFCSTSSPATIRPIIERRKAFSITPIDLGIMKLVVGPSIHDHEHFFRRLLETRTICGLECLDVFLSGHSGDHDTTWDSLEASMEGSCRSIQSLNLTSGLYISLDSLFEPAYPRMTEYIKSTIPNLVCLQSFKLCIELPRPDSGHIASKTWSLYATALHALPPSVRHVTLVLHPAPDFDECILPPVGFQRESYILPCIVFWGRIHLDWSPIRAAFSRLGQLETVTFAVRRGSFLVDQESDWKKIRKELPELDNRGLLRYKKLWSDYLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB75</accession>
    <name>A0A2R6QB75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB75"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="17673" checksum="7200DD4CE49F6F22" modified="2018-06-20" version="1">MKLEKDEITQRLRAVKEAAKHGLESSSRSLDGVRSSLDNLKAQSEDAFAFAALAKFSLADVEELRTTVTETMKGLQVSNLAQCLKDQQAELNDALANGADFEAKLIASEERISQIREILSGKEAELEALTDVNKENTHLQTTLNERDMRIQELESLQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB91</accession>
    <name>A0A2R6QB91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB91"/>
    <dbReference type="STRING" id="98765.A0A2R6QB91"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="20"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS05385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="849" mass="94686" checksum="F35BFEA66C43D6C5" modified="2018-06-20" version="1">MVSQWLYYSDQIRGLMNKPTNIRNMSVIAHVDHGKSTLTDSLVFKAGIIAGSKAGEMRFMDTRDDEKERGITIKSTAISMYFEVNKEDVGAIKQKTEGNEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQALTERIKPVVVINKVDRALLELQVDKEELFQSFRRTIENVNVIISTYNDDVLGDVQVYPEKGTVAFASGLHGWAFTLRQFATRYSKKFGVDKEKMMAKLWGDNFFNPATKKWSTKSTDADGKPLERAFNMFVLDPIFKIFDAAMNSKKDAIGPMLEKLDVKLVQDERDLEGKALLKVVMRKFLPAGDSLLEMIVINLPSPATAQRYRVETLYEGPMDDETAIGIRDCDPKGPLCLYVSKMVPTSEKGRFYAFGRVFSGTVRAGLKIRIQGPNYVPGKKNDLFMESIKSTVLMMGRYVEPIQDCPSGNIVGLVGIDQFLLKSGTLTSSETAHNMKVMKFSVAPIVQVAVEVMNAIDLPKLVEGLKRLSKSDPCVQTRISANGEHIVSGTGELHLEVCLKDLQEDHAGVPLRISDPVVDYRETVKAESSIVALSKTQNKHNRLYVKAMPIEEELALAIESGHVSPRDDYKSRARLLADEFGWDVTDARKIWCFGPDNTGPNLLVDVTKGVQYLNEIKDSSVAAFQWVTKEGVCCEENMRGVRFNILDVTLHTDAIHRGGGQIIPTFRRVCYAACLLATPGLQEPVYIVEIQCLEKAIGGVYNILNKRRGQVLSEEQRHGTPIFTIKAYLPVMESFGFNCELRVATSGQAFPQLAFDHWESMSGSPLENGSKLEELVRNIRVRKGLNLLFQPDIPSLDTYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEV9</accession>
    <name>A0A2R6QEV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000355">
        <property type="protein sequence ID" value="PSS06857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEV9"/>
    <dbReference type="STRING" id="98765.A0A2R6QEV9"/>
    <dbReference type="OrthoDB" id="2418900at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35715" checksum="106E249D055060E9" modified="2018-06-20" version="1">MVQPLTQSCPGIHRCFYCGATKPTRQGLRSHIAQRQSCQAAFLAQGRPSIRSDLTGGLSSETDDVISHNDHAPDDGISALAPEGQEEPRSKRARVEDVEDIEAGGLPSDPYIRLDTAAGKVKGKGQTSFEELKKKRAEDAGQEMNPWDLTARRRWQCEIWEAKGDELDENGEPRIEVLEMWKRDPVECIRELIGHPSFQDCLRYAPEEIFEDPYGEKWMYNEMWTAEWWRDIQKLLPAGATIAPVILASDKTQLSTFSGDKSAWPVYLSIGNIPKAARRSPSSRATVLIGYLPVAKLEVFSEKNRSLYGYQLFHDCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIM3</accession>
    <name>A0A2R6QIM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIM3"/>
    <dbReference type="STRING" id="98765.A0A2R6QIM3"/>
    <dbReference type="OrthoDB" id="2804161at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS08846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="14923" checksum="EAF36009C002E35E" modified="2018-06-20" version="1">MRHDIFDGICPFRTGLFAKGVIPQPVIRMVFALASDGSAVKHLDVSNVTRAEAIESRKAAFTAYDIWCAGATPDTFGVIQPQEVDTYKALLLRSRRPFDPYVLSKAPNALDELRGQARRTMNPGASNPEEHYVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIN1</accession>
    <name>A0A2R6QIN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIN1"/>
    <dbReference type="STRING" id="98765.A0A2R6QIN1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="174"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS08858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="427" mass="46316" checksum="9519496C156AD088" modified="2018-06-20" version="1">MIAKLGAVVIYTPTFILPAIVIAVLGGYLGQIYMKAQLSVKREMSNAKSPVLGIFGGAIAGLSKLAQEAFKEETLKRLDRYIRASRSFYNLNRWISVRIDALSAGFAAALAFYLVYGGASVGPSGVGFVLAMAVSFSDMILCLERIQQYLVIEQEPTPEDGGKPPAYWPSSGDLRVENLSARYSPDGPKVLQNVSFHIKAGQRVGIVGRTGSGKSTLTLALLRCIYTEGAVWLDGMQTNMINLDDLRSNITIIPQVPELLSGTLRQNLDMFGQYDDAILNDALRAAGLFSLQRLQDENRLTLDSKIASAGGNLSVGQRQIIALARAIVRQSKLLILDEATSAIDYETDSVIQTSLRSELSNDVTVITVAHRLQTIMDSDKIMVLDAGRLVEFDTPEVLLENEKGLLRALVEESADKEALIAMAGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIQ9</accession>
    <name>A0A2R6QIQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000341">
        <property type="protein sequence ID" value="PSS08854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIQ9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS08854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7213" checksum="F8B84526CB8EFDD8" modified="2018-06-20" version="1">MSNSDYCEYYESKSVCIRQASSGVPLIAAAIQPSDPQYIDTFSGRYPDWSTELSQLNTSHFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R118</accession>
    <name>A0A2R6R118_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R118"/>
    <dbReference type="STRING" id="98765.A0A2R6R118"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF43">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015356315" description="Glycoside hydrolase family 92 protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="305"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS18931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40595" checksum="8C6FF5F96F7FAA94" modified="2018-06-20" version="1">MRSPWSRSGLLWCIWTIQAAALHAISGVASRGTPKVAFQQPPSDAVDCVDPLIGNGGDSPNGSGGMIPSTAPPFAMTRWVAQTRQNYVSVTPYNYTDNSVHGFQGTHQPAIWMGESGQIVVVPGAGDVKAVFEERGMAFSHTEEVITPSYYSVELDAIEGGTIISEQSATSRVGHLRFTFNDTERPYILIEASRASVMGSADPNNLTYPHGAVDIEPVRNEITGHNKERQDFIIGPNPATKFAGYFCARFSEPVVEWGTASNSDARVVPGQRVRSGSQVSAYVRFDESIKTVEVRVGVSFISVDQARRNLDREAPDGTSLEKTAQGTREAWAEKLDRINIDGASTDDKTTFYTAVFHTLQVSSYFKERGKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6REN1</accession>
    <name>A0A2R6REN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000262">
        <property type="protein sequence ID" value="PSS28485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6REN1"/>
    <dbReference type="OrthoDB" id="2692137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS28485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="696" mass="80283" checksum="F77BBF57712F6E3E" modified="2018-06-20" version="1">MASHPKIWKELVRRSPSTGESIRWRDGLVGCATDDGKSVITSPNMSYIPRPTYGTTWISIKADGHYGQADPTQWPQVLVEKSRFPWFAAVPRYPSLPHQSRFLVMWSLLPLTEFVPLAHHMKEVLGDVKLLGTVHQRRREKLEPLVEEIVRKAAEFQTRHGRNRELDCIVTTMKDTFERLNYPSTYRDLVRQHACVQRYWRMAKAWFEWHIDVMKNYTLDDKPSPRDSHVRQHLMGAYTTSPVIAKRLFDLGVPVWFARTVDHLTSQDVIQTVVHFEEPKNIIVEEGIFTDAKGFLGLAGSEAHLNFIMTNGNHYADLEETMMPAPASFRPVSSFDPVIKSRNISTASSSYTTSPATAQPAHGKHQVPAKRPCPEPQRDSDKPRSKKPNPSEREKFQPFKHALMPPSIPVWERALASVDLSTPSPSGDAVWKFWFPEPKLVISSEVAERQMRYLMNWLRVRTAWLYIVTHRSMQDGIIGPLKALEWREYLNSSNQSEQDILRVQTQESKHTRRKKDVSTIFQLVLGVKSVLEIPVPREWFGHSLQGAPAEEAALCHRQMIWELCEVAFRYELLQLDRYLVPIDEPDYERHLSEHERRRLIASVFPNDFVMTALPTRIDGLAALDVSTRLPYLECLQKILSRWPGAPDDICSTRIRMYASSVPRVEWIEKQMAEFYCQTFYQVAGRAPILPRRFPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIJ3</accession>
    <name>A0A2R6RIJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000250">
        <property type="protein sequence ID" value="PSS29847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIJ3"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="425" mass="48990" checksum="EA07DBC907B7A818" modified="2018-06-20" version="1">MPARKHNLKNPQLTFHTVATRRNIALLRIGARFPQELFGRVLHFTHASDGKRTLGQLALTCRYWATKCQPAIFEKIKLQSSKDLDELLVLIESPLSRIASYIKRLQLFQEEPPKPPWIHLVALRLVPKLSLYTDTPMMLFLSKAAISRGFRSIHDALPRVYPSFSSHISYLSLWNARFNSLADLFHLVDEIPPLRELNLRCLTWPATAPDTQPVVLPQRRIPPHLFYVDVSKCTDNLAGIQILTGRRRKVRGETSTLDFDLDREQQHTIYKMMLAMMEGHPDAHCKLRLDKVNYVYNKITVDRTLYYGALLTFILSSDSKHNIEIVAIDIPVYSDNRLEIFSTVCEHLPPLQKLIIGFKSKEDISHYVHKVMNPKLGDLRSVDKVEYAVLGGEYGKYQWLRKLPDSEDWKGSFHPLIFSARNSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIJ6</accession>
    <name>A0A2R6RIJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000251">
        <property type="protein sequence ID" value="PSS29835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIJ6"/>
    <dbReference type="STRING" id="98765.A0A2R6RIJ6"/>
    <dbReference type="OrthoDB" id="3266934at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="37"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS29835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="499" mass="51813" checksum="282D1E5EDD8FD704" modified="2018-06-20" version="1">MGSLSQTVVPLNPPHIPGSIFSPGLTPPIVSFPGSVLSTPTDLSSSPTLSTTSPSPTLPDTTSTPTDTTSTSSPMTSLPIAPGSSQSVSQTPSSSSVQNSFSHTSSAVSISLFSITSVSSTASFSSTGSSSSASPSTSSPALSVSAVSSSHRHAGAIAGGVIGGVAVLVAIIAALIFFRCRNVAPRVRRRNGDVLAPTGGAFRKWDGLASRDSAIGAALPISNATYKVAPTRHASTGSAAAMISPPSSSLGHGRYTTTPGLSHENEDLSDDEEKWPTTPSSTLQGHRPFELIETVPPLPVDLSSAPATPMSAAFPHGRSRERSASQNRALTLAKLDATALPRSPYSPYTPTSPSATSHKRQSLDGRVLSSPSGSSSSHYPMPPSTEMIRMARTSSGTKRTARKAVPKYDEAEFAAVAPSMSPSPFADQERRQSSYYETATTHSAETSSSNLHASIRAERSREDLEAAGYEIPALTAKASFGDMRNVHYLIPDLPPPQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ30</accession>
    <name>A0A2R6RQ30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v2094</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000195">
        <property type="protein sequence ID" value="PSS32138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ30"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ30"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS32138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="14733" checksum="53F5A9E0A3525F49" modified="2018-06-20" version="1">MSGKGSGKAKSGGKASGEASGKSQSRSSKAGLQFPVGRVHRLLKRGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKQRIVPRHLQLAIRNDEELNKLLGDVVISQGGVVPHIDPALLPSKTQKGKKGESQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQC8</accession>
    <name>A0A2R6RQC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000179">
        <property type="protein sequence ID" value="PSS32225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQC8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="894" mass="97762" checksum="19EFC2BFC8E84C7D" modified="2018-06-20" version="1">MDFLEYLYAAIAAVFPLLSGLRENLLYEWTRTLGLVSSTVSRFSIQAGDSGLSLPSATATLDPVTYDLDILDLPPTSIDAYNFPQVDYPTEYHPIFTAVRQVYSAWIPKPPSLPSIGKCPLVVYFSVFIFTACYALWTRCRSVPVTKSRPKALNPLPSGPSQAIPISSHTSDMPLYVTPEVPDYPEVVFTNLPPSSLDLVLRNRHLSLHLLDAPTVRTVDTSAELDFSMPPLLSAIQDPSEQLVDVGNSVQNDVKIGPDQMNAPVSVGCLLERNEEMALPEVPYGISRTVLSEAPLLLSAMNRDIPNPFNVSVGSFPDVSFLACLSDLTTETTTPTAELDPAEDPYGTDPGSSLDGATACKPAMDTYESCAAQLVDTSLPNDEKIPGLVPPEPDYEKTCVTDLACSEDYNVNDIEHILSPRAAEDTEDFEAYEPPSSFPFMHFNNDLGDLLGEDLDDWNWTLVNLQLSQRRSFVCGASNQSAHAQPSEYATANKPNILDGVFPRDLPPRVKIPGLRRVRSEPSFASIRYISRDDVDPLPRLDQPELVACYPFVATRVGIIHHDESFRMYEPPVQLELAVREERRATLLAIQHKKLKKNKSTPNLQRVGLSREAFFAIFLRQSIPRMTLSYADAVRIGLVKQRARMITAPTTDSAKTDPSWARVPNRLVVLNRNRNGQDKNINGDNQIVSRQPHRRASFSGRSNASGSRARTLSGPASGNPMLGGQTQPFQRAASEHLIIQPVVRPRAGSFQSNAAYTVPSHRPPMSSGVASNILHPASASPCRPNARLGKRRESSPCVSRPPVLETIVGSPSHSPIPAPVCGNIIRAGSPPPLSLDARVAKARNAYGPMAVMALPRIDDEDALADVPAKIVDGKALREDEVMVSQMVAWTTVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVJ7</accession>
    <name>A0A2R6RVJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1951</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02000162">
        <property type="protein sequence ID" value="PSS34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVJ7"/>
    <dbReference type="STRING" id="98765.A0A2R6RVJ7"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="566"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="816" mass="93237" checksum="9EC94CC0AACB03A3" modified="2018-06-20" version="1">MDKENKDDFTFAKLTDLKLPVTLRISQLEGIRHARPFTEILEKPELRFHGVQQSPGFSDLYVTCQLVADNKPLTIPFRTSFKAFKKDYTWNEWVTFPIRYCDLPLSSQITFTVWDIAGPRSAVPVGGSTFRLFGKKWSLRRGKHRLLLWTDCEADGSNETTTPSKMGNRDEMGRLEKLVKKYERGDLPKSDWLDAMAFRKMAEIHAAETEKSQNLFLYIDLPRFDFPVIFTEADTSAVPPTSTAVASPPPPATTVSSSLASDTHLWALIDPDIAKENPVEDKHRRLVRSHRSSPYDREMKPNAKIRDDLNEILNYAPSQPLTLEEKDLIWKFRFYLTRDKRGLTKFLTSVTWRDPSEVKQAVEELLPQWTEIDIDDALELLGPNTVDSRVRAFAVKQLSRADDDELLLYLLQLVQALKFESTANDQRSARSTSSAISYDDSGLADFLIGRAVRNLILGNRFHWYLMVEVALEDRIMAKMYGRVVYKFMQKMLELENGAERRDLMRRQGELIDTLAKRAKDLRTSKDPRPKKIEKLRAAITDSKNNLSSMPPLPLPLNARVEVTGIIAEKCSIFKSNMFPLLLYFQCSDGSEYPVIFKDGDDMRQDQLVIQLFTLMDKLLRKENLDLKVSPYDVLATGPSQGMVQFIPSKTIATIVSENGTLLNYLRANYPDEGSVGTYGVEPAVIDTFVRSCVDFGYILGRDPKPLAPPVKVCKEMIDAMGGVQSVHYARFKNFCFTAFTILRKSANLILNLVTLMVDANIPHIKHRDVHEQVLGKFCLDLTEEQAIEHFEKLLNDTSPFTVVLDRMHDWAQYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVU2</accession>
    <name>A0A2R6RVU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xaa-Pro dipeptidyl-peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000149">
        <property type="protein sequence ID" value="PSS34148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVU2"/>
    <dbReference type="STRING" id="98765.A0A2R6RVU2"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="1">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="27757" checksum="D3F54C7A98486D63" modified="2018-06-20" version="1">MQSRPDMLGVRPFSREVIHLPSGLTLEASLSVPSEASPAAENKLAICLHPWSWLGGRMDDPCVTHCWSTYSRIALNLGSGYHVLRYNSRGVGNSSGWPSLTGIQEANDLQEVVQWALGAIPSVSSLVVLGYSHGSLIASLFPILPETSNVRVSHILLSYPLGPRSWLTAFHGKHYASVLNNLIRDPRSNVLVAYGNQDEFTGISSYTSLADDLRREAQGRDNLQIVQVDGANHFWVDDVARGRMLGVVQDWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZK0</accession>
    <name>A0A2R6RZK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZK0"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023251">
        <property type="entry name" value="Brr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02039">
        <property type="entry name" value="SPLICEFRBRR1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="38746" checksum="5E65AA68FCEBB231" modified="2018-06-20" version="1">MSSKRKRTDLDDSDEEEPALGKQVLPVANLPADFNGVPEDGLQYLFTVRRDARLMPHVTRAENPYEIEDKPHEDLLTLSITNDVLPSEKWRDIFLKRFKNFRKNCVQPTIHINNPPRSTLKVIPDRKDREAWWAYLTGRPESEWNPPKKVKGQNARNQGYGRGMRAYSLETQVNLYQETQGAGPSREDTHMNEEREVEQAVAMDPTESLPTPSGTPAPPDRHPGTSASEQVFGEETNLMNITQPEPTPIIMRHMDHVDDILSADEMSTLRSLARSCASLIKDRMQNRLPEADEASHKEVGELDRTIGESSCWMIIATVANMWGQKDLWMDAKEMLSGVSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZU4</accession>
    <name>A0A2R6RZU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000119">
        <property type="protein sequence ID" value="PSS35555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZU4"/>
    <dbReference type="STRING" id="98765.A0A2R6RZU4"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11500" checksum="70D86D24478A1287" modified="2018-06-20" version="1">MTLALPIASFDINDHSKAEHGIQGLVDLVNWEVWKRNEDGDSVRHPLPIDANHLEKTGIFPENHPIIPYLVPAPTDLLDNLSMFSDDLMERLLDPPRLQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZX9</accession>
    <name>A0A2R6RZX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000118">
        <property type="protein sequence ID" value="PSS35557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZX9"/>
    <dbReference type="STRING" id="98765.A0A2R6RZX9"/>
    <dbReference type="OrthoDB" id="2593174at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF63">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="530"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="693"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="907"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1148" mass="128302" checksum="09429F1BD3AC12E8" modified="2018-06-20" version="1" fragment="single">DSIATSGRRCQSTENIMWSKLSNVLKARPGTPGLGPEEDETVEGTTDVLGSVFEQHPNLSVFHQPSEVPFPSPSPPASPSKHGRRGMFKRMSKAVVPHNDSTDTLPKIGLPKKVKSSLHSISTGSQHSLGHASGDAFTRQSQDTARPSIDSTASRSLIPSTPISENKYGSMEDGRFGSLRSILKPGSTPGASKNVRFFSRDAYRVMSPDQSSAEIEEPSLFNRLQRAAPSRPTAQQLFLTPPPLPAKDGELSTPINAQPATSTPMMTPMMIPPPNLGNIFEFSENGISDLPTIIPNTRAPILDSAVEVFETETETETETETETERDEQGQHSKTEDSLPIPETLGTPFGDVLSESSPMRPPPGLHDRSHSFSFGQTVFHSLKSHENASPAKSEPIISNRSRALSDTVFTSMLQSPPTGLTNLKRPEADINDTSEAIVAYQPPEKDPFAANAVTYYTPGTMLPPSPPQATHTRTASREEDLIWSLRTQLALQSELCAQYEVDLAARDELVDTLNTRLSDTEKECDRRKNVVRNWRKRVAELEKCVKGLEEEVDRSRGESFDRSIMDEASGEAMRILHRRINDLERERKDGEQREKEIGRQLESKDEELKRVIDELNTRYQSERELKAGITAAKEEMEIMGQQGGQEELKSIMAKNAEERERHHTIESTWEREREALLATNHSLRDEQFESQSQITGLREEIVRREDELAVLKSELEAQWKHTEETGEELEQLRREKEELSAEVDVLRTQLSETEAEWDDIENGKVELQNKMQEVWASNESLEQEKAALTKNLRDEQDHAEELTRALQEREDRVAALEQQRQHAYDNVSRLQENMRQRDTELAEYSRRFREREVEVDEIRESLTRQKRDHSRIVDEQSRKLSEVVAREVESRANMESVIREKAESDVLLNTLKERSTVLKEEVERLRRQIHELQQESADKEVKLAQAAKQRAQDKEDLQGLNIALDSKQQELELLKRRVGTRASVGATPAPAAKIPFRRESSIFGTPSVTRPPSSLSDTGSTAKERKLSDPPSVAARLRVRANGSAAHSTKKTIDGFMGPPPLKARSSLAPTPLATPSRIPSTSSLARSSSATPLAKPARHRVSTSLESLRAKGSSTSMLSASDVSEQSEKENVNVTPAARRRMSIAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3D8</accession>
    <name>A0A2R6S3D8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1857-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3D8"/>
    <dbReference type="STRING" id="98765.A0A2R6S3D8"/>
    <dbReference type="OrthoDB" id="2320332at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17656" checksum="F2FC74DFE1B665B8" modified="2018-06-20" version="1">MKFHSAHTAIVNPPSASPVITQEQLWKALQQKARDPLRFVPVIETCDVIKEDTGGLTRVVTFKPGTGPPGKITEVVVFAGQVKADFYMEDIGTSISNIISLGDGGDTDMYLTFTFTWNFPEIQEGSEEATTKAKQLTEVSKNAAAHTVKQVREMLKDKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3G0</accession>
    <name>A0A2R6S3G0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3G0"/>
    <dbReference type="STRING" id="98765.A0A2R6S3G0"/>
    <dbReference type="OrthoDB" id="2392789at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="283" mass="31219" checksum="032B7EA988AF85C7" modified="2018-06-20" version="1">MPSPEPLSFLASGRPDPSEYQYIVPRTPHSRSGRAEEAVTETELDDDAESYATYRQQQSEPLLASSASSSFPPSGYRSRGDDHEGTGKPSISQWRKQFSGKAVLYNTPLIVGTVLAGLILVLIIISYKQPQAIEALIGEDAKLNAQTTEDQHVASPAPVPTPTYVDTYPKPGHLISYEDYTAFPLTGAQYRHECNKMMGGKFMHHSGYWIAPQHGIMDTKHHDDVTDYHLPEGGRTRVCSKTITYQLDGHVGLAADLALMAQVAALARERWLREGSEEGAKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3S8</accession>
    <name>A0A2R6S3S8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase molybdopterin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000093">
        <property type="protein sequence ID" value="PSS36913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3S8"/>
    <dbReference type="STRING" id="98765.A0A2R6S3S8"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="6">
        <location>
            <begin position="72"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS36913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="259" mass="28717" checksum="E882B16D941B922C" modified="2018-06-20" version="1">MSSSSSILPQPFYPVSLRNSVQEREESLPDAFPTVPTYRIPDAIFVPTGFITPAHLHFVRSHGAVPQCPPLPSSYETWQIQVHGRVAHPKTFTVRNLAETFQVVTLPVTMVCAGNRRKEQNVARKSLGFSWGSAGLSTALWTGVYLSDILAHVRPLKSCGARHVIFEGADQLPKGPYGTSQKLSWAEDKAKGMLIAWAMNGLPLEPDHGFPVRLIVPGQIGGRMVKWLTRIQVSDVESHHYVSQPVWKHANADPWELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S446</accession>
    <name>A0A2R6S446_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S446"/>
    <dbReference type="STRING" id="98765.A0A2R6S446"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="16341" checksum="3196360F3FEC9357" modified="2018-06-20" version="1">MLSLGALIWVSVRPLLRLVLCTGFGVLITRADIFPAVASRGAGQIILVRKVVSALNQYLPKKPGPLFLVAFIYEGMGLLLAWIVKQFFWVPHRFRYGILVAGGWGNYGDIRTPPSYLYSDLADDQSPYQMGSNLGRYEYYRWPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S494</accession>
    <name>A0A2R6S494_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S494"/>
    <dbReference type="OrthoDB" id="2754671at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="195" mass="21197" checksum="6F435BBF534B766C" modified="2018-06-20" version="1">MVYDSSNPLTSAFQHSLSSTISDSRSSYPSSSPAEVVVQDPISPPSSVRGWAMTACPVQVSSAAHYRKSLVKTPGLTRTSAAEPVVSFAQAELKQSPNSGMISMVVKSSRGKKPRTRSPYPVLRGRKNSPLRYRVKVSDEDLAGTLEGDALSEKFGLDKFLPAALPKRKGSDENAQIDELLERGRTKSRFRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4I9</accession>
    <name>A0A2R6S4I9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4I9"/>
    <dbReference type="STRING" id="98765.A0A2R6S4I9"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="76"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="323" mass="34220" checksum="1D9EB1E40FAAF8A7" modified="2018-06-20" version="1">MDDLANIDGELDANLAELSLGQRLTALSGTSDAAGLRTASSDDEGDKSEKPDIAIPQIVPASSLTRTLIQALHSSDSGLLETCLAHTNATLIHNTVRRLPPQLAVPLVTACVERLGRGKGVGRGKGGGAGAGAQRGTGLVKWVRAVLVVHGGHLLTMPDLVARLSGLHATLTARLALQESLLSLSGRLDMVISQIEMRSSVAPAPLPMPKSSKSKGKEKKQQPQQKPVKRYVEGESEEEEGEGVDIEVESGDDAGSVEDVELGGSDEEDDDSEDESEEDEEGDDSEEEGDYDDEDSDLGSKMNGFIDDEADEYTGDEDEDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Q4</accession>
    <name>A0A2R6S4Q4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Q4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Q4"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="99"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="28931" checksum="2DE0DD1BCE5D375B" modified="2018-06-20" version="1">MDNGINPYADPGDGIMDYDLSNPMDLFYTGQASFVREPLNYHLYTQPRPENLQHKYFVSDELREELQKRSESIYITPPSGLDLPEETQGYHSLVPLEPVVGERHNFSNWHSTVYKAINSMDGFPYVMRRIENFRLISESALSGIKAWSRIRHPNLVAVKEAFTTLAFNDNSLMVVYDYHPNSETLNEAHLKSKAPQFINGRLQTQNTRVAERTIWSYVIQIASVLKTVHEAGLAVRVVDDNKILVTSKNRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5C7</accession>
    <name>A0A2R6S5C7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S5C7"/>
    <dbReference type="OrthoDB" id="3228777at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1336" mass="143890" checksum="4F89B93928EA064D" modified="2018-06-20" version="1">MSRLGLFSSKTDQSKPGQSSVAREPEKAEEDWYIPYNGPYEPPKRPEQEEDRDSWGELLNGWLSEDESGEKQGAYRRDGRGSHAASAPDVERSRSRVVSNTSRHTHSTNGGRAPQPRSNPQPRMPTMSYINLDQAGGIGDSPVPPERTPTQRSGPSTTQQPQQPSALKRGSLASIFTFGRKSLRLSVSMDNMAPEGRRSVSKRDRSNTEAPLPSSAPPIPRGRQRAHTSANTAQLDPVLGEDDYYNSYYSTLLATPRNDIGPSVVGKERSHPYAYPFPEATTTEPRSAPATVDIKGKGRLLNSNKISFTLLDSRGAKGVPAYLKPSPRNSLLKASISAPNLRTIPKGKQRWWAAETWCDAIMLPRPRFAMRLMDEEGRIISPSSSPIMSRWSPDASTSTQRKTDIRSKSPTKKLAGNLVTSAAAGAGEASYTAHPTLNDSKSKPSRPKSFALDDLALPSPVPSLAKVLEEGRQLEQDRKQWQSKASRSYLDNRAGIMSRARSKSIGAQGRPRLRSKEPEGAFELFTGRTLLGGQTRPPTIHVRGPSVSKVRVRSQSQTQSATAQGTVQSTISQVFSRSGSRTRSHAHSNSVGNSTHKSTSDGSGSGGGHSRSQSVGKSALRMVVSSASNAAVFCGLGHNSDRGTLTPLSEKETAMEGALRNPGTKIIHLQDQIQPGGKGGENDNLVVLSSPSAALAMVNRSGMNGVSPTPSALSGSGEGVGIAISSPSEELNRQLGREPIRIPTHPYAQSFSYAQRQPVLTQSPESYHFPPSPPAPAEISAVTEEHNKQRQPIIVHPYAQPGHPYAAAPSQPRYAVPQHLKIPPRVPNGMFVEFSPGHVREFAPGDLQYSPDIPTPTVVQTSQRQPLLSSSSHPYAPASKRMSELGFGEALMHTMRRTSTDSGLGISEPSIYGTEADWERPVTDVSPGSAADDIALIHGIMRSSSEPTSLGTGQRPATQRDASGGVLSNNTLASSPPEHVNPPDFRRTASAVSGGHLSFLAANSSSGSGSSPGMISHDSSPPLSPHPINTNEDLERFRDLFYRPRDSQSIASLDDFIRPALSHRPSSGIPIDVSSESSRSALTRSGLSDLARQLSEDLEELRQERGSGIESEVDLPPSMWGRRYGGLRGPRPDDMMTMDDPNVVLAQLTSTSGSGSPEVNTSPLRLPIDTSFVSPITNIPEDVESSRTSSILDLSPFPDETAELVRLGAIEAVSTPPIISTPQRFSTELSFFHHGNNNNNRDSDDAPPVPSLSQRSTLLTPLSPNTRSSYMTSNTDTSRMSGLSDFPAPPTQVMPPSSQTTTSTSNLSVPPRLVREFSHGTFGRRDDEHSIVGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5V1</accession>
    <name>A0A2R6S5V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5V1"/>
    <dbReference type="STRING" id="98765.A0A2R6S5V1"/>
    <dbReference type="OrthoDB" id="3258282at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="574" mass="64154" checksum="DD4A31E2DF2C5140" modified="2018-06-20" version="1">MQTTRNRPQSLNYFQQSPVRGQLEPVDRSVGEGRFLQCTDTPNELKVLLPAKTSTLYGNLLAAEAEELRKGQTTSWDRIKEIRRLKERMIHKCERLARASVADRNATPMITLYAPPEFRLREMEKWLKQQSVDHGLQNFSCCSMCGPLGPQDSRPTLSRKASSRSTSVIATRTAITTHGSTTTWIAPSYPSTRTVAAPVSNHTASARATRSNPVPERVPKLPAGSSSQTYIEPDPAAVHSQPKKSEPNHQPSRTAQRSNSLRSREGLHVPNAIRQPGSPPTKRPLEPIEQLRHAPPSREASAEAHSLPNKSLKEPIEQRRSPKHELILLEVHPRALMKSPDPLPIPHRPRGHQEDVVRDTSNSIVADHSAPASEVASEQEPLVIPDPASRRVEPPEETPEEEPTPFPSTGQILETIHEKPEESEVCAARPLIRRRSSLKNKTSMSKLSVGSQSKSVTWAMDRAWTQQMAEIVKNTNEAEVIAYDVGEIRLQYHEEMAKMRITCHDVLSTVQALGADTELCQREGVALVQQENKILALSDEIKRMEASYKEKVVAVLEETKRLVELCDKTRDLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6J6</accession>
    <name>A0A2R6S6J6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000023">
        <property type="protein sequence ID" value="PSS37892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6J6"/>
    <dbReference type="STRING" id="98765.A0A2R6S6J6"/>
    <dbReference type="OrthoDB" id="1111611at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="13532" checksum="D189106F742E04B5" modified="2018-06-20" version="1">MKEALARPDSQQWMLSMVEEITRLEARNSWEYVYAPTDANLISARFVYNLKGDEHGNPTQYRARLVAQGYKQVEGLNYNFDDIFAPDLNQYAPCAQSQQSKMMNSSRPTSNPLSYTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7B5</accession>
    <name>A0A2R6S7B5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000001">
        <property type="protein sequence ID" value="PSS38142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7B5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="421" mass="47892" checksum="41DD2CAF3EE67652" modified="2018-06-20" version="1">MDNLPVELACAIFAQLKARKKNKQDLASCSLVSRRWRQITLPQLFEKLRITYRVHDYSKEACPAESEGKPDIAVFVHSLDLTQDDWTTEATDPEILSLIFNQLPSLRNVELTNVCVGETFGDPSIEHVVDRHLDRLRISLDHCNMSGYPVPPTPCILRTISFFRSIDMLSLRNGSYRDKTLVDDHSTGLPLLSLPAPKQLEIGNSFPLHLLIPILNSQSLLRNVETLIMGNAKRIIADDKDVQAIEYLLTYVSATLLYFAPPKFEYKYADVQSTLLSPLRKLETLYLTIWTVDPTADWLDTTHLLRSTIPTLRTVHLDVQADLGTQRETKRYFEKAASCIMHLEDILMAMAASGSLNRVILSLTDHNSAMKRPFRETVIFHFGKIFPRLRKQGILECIRLSKPEHHISISGLSLRLAFMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7C8</accession>
    <name>A0A2R6S7C8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000001">
        <property type="protein sequence ID" value="PSS38152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7C8"/>
    <dbReference type="OrthoDB" id="2799001at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19456" checksum="A30868F3D1160A3F" modified="2018-06-20" version="1">MIAPDSLADIPPSPWLCEDVILFLRSAPAHNTQAVVEFIIDILRPLARRDTSLQDRDAVVAANSRYPASPYLWFTVYLACDNKTASSLLLASGLLHILECLYDTEFSDRPPHGGRIKNLLWQNKHDIRRICYLVLSAISKHIDLHDFLLLEQLTYDIRMESRRLSELLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDT8</accession>
    <name>A0A2R6NDT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v13573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NDT8"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="858"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1283"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1305"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR70534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1316" mass="144032" checksum="DC9F5494C5FE32F8" modified="2018-06-20" version="1">MPTSGLRIDTSVVGIAGASSSHSSSRNGGLTPGSSKARSAKSIQRLRSASSASASSSTSNPLHILNNGFTSSARPVPQSSSSETAFVESDPSTWSPTDTTSTESGQDACEYVLAMHDFIPQQQNVTCLAFAAGQIIRVLNRDGSGWWDGEVDGRRGWFPSNYVTSDVSLLTEEELPRTINARNRKGHTQQMSTASAASWTSTSSSPSSSSSKRNSFTRTDHRPMASESSMDTYCPPLMVPLLHAITLLQNAVRGNRPAHFQPSAACIISCVRTILSEVGCLPREAEILKKHEILARERKRILSDLTSLVNQAKKASEAELGEQQRQLEVEGMVRLGGQLFAHVRGLLAIAVQCGVSIQPSSRSHGSERGSVDTEGRWGSQEGTLVRSDDDAPLPENYDPQRDSVGGTTNGIEHRRRQRDLTSAQHMRAKSLSDLKHGQKGDKEQHLVPKPQLKSLGRTAGKQMAALHAKRFTSAPATHHRSGQLSVSSVSSSSSFSSGESVGMPLTPVFPSGPSTTPEVMEALRHTHDHYLSTIAAFIGHAHSHSRTSHASSTGHMYDLVREVVEMVCKLLTIVEAILRHPDIPVPRASDLRLAKEGLYNVTSTLADSVRQLTTSPLPGMTEEEEKATLLRSATNALKAGADCVNAAKRCLQRAAGEKSLIIELPSVGEVDPSSYTPSKFSHHAREGSGRLRVVTGGSVLDTLYRANGLQGEEEDLTIQAQTASFDIDTPTKGDKVPNRTDLPNLETLTVNTEAPSDTEGEVWSPAPDVEKPLPPVQANGELASLRSTSPVSFVPTDDGTTWEGAHSLHRPQLSLEEKLRHGDLPTVPEGSLPDVPRPDPLTWLLSHDYAPDDVAYNSDGQLVGASLTALVERMTPHDSLVEPAFAAVFFLTFRQFTTPTVLVEALISRYNIFPPPGLTEADTFIWQQQKGLPVRLRVSNFIKSWLESYWRPGTDNNVLTSLLAFTRDALAMMFPSPSQRIMELIMQWTAATQTGISPKVDRIRDAGIPLNPPSAVLGSEIPRPIMTKAVLSALRSRNFAAISVTDFDPLELARQLTAMECTLYCAIQPEEVLETGQTGGIYPGNVKLVTSLSTVITGWVAECILNEPDTKRRTALVKFFIKIADRCASLQNFSTPRSILAALDSSTISRLSQTWTGLPQKNRLQLDSLRKLADHARNYHEYRSRLRNTAPPAVPFLGLYLTDITFCREGNPSHRASPKNPEKKLLNFNKYHKLARIVQDMQRFQVPYTLKEIPEVQEYLKESFEQSKNRTDLQDLYRRSLLVEPKRPADTPPSGDMRQLFQWATRGQQTTPTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDV5</accession>
    <name>A0A2R6NDV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IncA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NDV5"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19129" checksum="5DDE0F6EDF92C28B" modified="2018-06-20" version="1">MSSVLTRSVATFRPRSAQVSQRWISTTRAVREEVTSPNLGTVPPPKKPVGAFRGGIVGFLFGFSLASSYAAYHLLDEYKQASAALQASVEELQLSTAKVSAHIRRIEEVEKDLKALRESSSSKDDISRVRAEMKKLYDGLHVEFLDLRSHVWGIQQDLHSLSKKDSTSVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDX0</accession>
    <name>A0A2R6NDX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF323 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v13603</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDX0"/>
    <dbReference type="STRING" id="98765.A0A2R6NDX0"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="231"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="623"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="761"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR70564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="95123" checksum="67221CB16696B8E6" modified="2018-06-20" version="1">MANTRASIDILDIRGKHALDTDQDTIQEQILNGLSRPAGQKTFPTILLYDETGLRLYDVITTDAPEYYLFPAEEQLLKDHGRDIVKFMHARNGGQAQNETVVELGAGALRKTSHILRALAQLIPNAMENPPITYFALDLEKRELERTLHELAKSDVGVEIQGKVATKGLCATYDDGLEFIKDGGLQCSSDAERISLRLSEHYKVESVSRDLSPSSSVSGETETTPPSTPGSERPPFHLLFLGSSLGNFTRGEDVAFLKSLPLQPGSGNTLLIGLDHGHEREKIEAAYNDCNGITKEFIMNGLAAAGRALGDEHLFAQENWEYVNKYNEELRRHEAFFQSKLDQIITDPHSQAEFRFFANELVRIEISHKYSEKDAYSLFTAADLRPINRWTDQSSQYSLWLLERPQFTFPLLSTPNLTKTPFGVPSVGEWQDMWAAWDFINKQMIPPSMLFQKPIDLRHICLFYQGHIPTFLDIHLSRLLQEPHTEPENFKPHSEVPQSEDEWPSMGSIMAFQGRVRARLLKLYDDISSGKFKLTRKVARVLFMTLEHEAFHAETLLYMLLQRAGTGTIPPSGFVIPMWDILSRSWESAPQPPSATVTLGPATLTMGHDDDEADDSSMEVAGHEFGWDNEHPKREVRVNNFRIEWRPITNGEFYAFFTGAGKGKIEQPASWVAVDGELQVRTLYGPVPMKIAWHWPIITSCDNLSTYASVKGGRLPTEPELRLFFDKFNCDYDGGANIGFRNWHPVPSTTGLEKWAGKGHNGGVWEWTSTVFDAHDNFVPSKLYPGYSTDFFDSHHRIVLGGSYATIPRLAERSTVRNYYQHNYPYAWAGARIAYDIQDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NES0</accession>
    <name>A0A2R6NES0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NES0"/>
    <dbReference type="STRING" id="98765.A0A2R6NES0"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="66161" checksum="8853E7A5DB729AFA" modified="2018-06-20" version="1">MTLVVGSEFPADTKAAGIPLSPTSSLDKDASSKISVSSSDLLPPLDEKPRFTDLLLNRGSRQPADLDAIATRRSVFDDPILAKHYLPSEKYENRHRFDPNARWTFREERDIVRKIDWRVMLWAAISFSALNIDRGNLSQANTDNFLPDLGMTTDDYNLGNTVFRVAFLCAELPSQLVSKKIGPDRWIPTQMCLWSIITLGQFWLSGRSSFLVCRALLGFIQGGFIPDLILYLSYFYTKTELPLRLAFFWMSSNVCSIIASFIAFGVLHLRGTLGKAGWRWLFLVEGLLTFVIGFATFFMMPPSPTQTRSWFRPNGWFNEREETIIVNRVLRDDPSKGDMHNREGLTIKRLWTAVCDYDLWPLYILGLMFGIPPSPPGSYLTLSLRNLGFGTFETNLLTIPSTVFGLITMFLVTILSEAVNDRAIVSMLEDIWTLPFLIAIYCLPENPNQWVYFGLATALLSYPYTHPIQVGWCSRNSGAVASRTVNASLYNMFVQLTSVISANIYRKDDAPRYRRGNRVLIIISCVNLVILYPSTKLYYIWRNKQRDRIWNAMTPEEQVHYLETTKDIGNRRLDFRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF46</accession>
    <name>A0A2R6NF46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001297">
        <property type="protein sequence ID" value="PSR70993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF46"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="10698" checksum="3E531F72B6DF43F1" modified="2018-06-20" version="1">MTTGPFSVGYKSLASTVAILDKVSPMETPVARIGEGSSTSSLSTSLSPSTAPPMQPSPQKIYSGVVVAIVLAVLVGVVGIIILFLEECLRMAALGAIHTCINHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG84</accession>
    <name>A0A2R6NG84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001298">
        <property type="protein sequence ID" value="PSR70992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG84"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5163" checksum="A6D9F0A880560E3C" modified="2018-06-20" version="1">MSGELQGRVTGLGAILDLCEFELIPSCTPAGMTHGHQTEYAVGEAMQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGX1</accession>
    <name>A0A2R6NGX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGX1"/>
    <dbReference type="STRING" id="98765.A0A2R6NGX1"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000014">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="26445" checksum="46423BDD78842ED1" modified="2018-06-20" version="1">MSSRRGSTGWMMFMGEEKSVRKNIRKNGRFYGSSEIAADVAEYLGPNPEVETALKEFQAALAKYRYMDHSLAQRRRGLEEKIPDIKKTLSMIEFLQERREGKGKAEGEDEDDLDDLEDEETSKQPLKTTFELNDTLYAEAELEDTDTVFLWLGANVMLSYKIPDAVALLRTKLESAETNLAGVIEDLEFLREQITVMEVNTARVYNWDVKRRRDIREQEAKEDSVVGKSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHN0</accession>
    <name>A0A2R6NHN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001240">
        <property type="protein sequence ID" value="PSR71859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHN0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5503" checksum="CB079EC0ECA27657" modified="2018-06-20" version="1">MGADLDHSPAEGTDYVAEDADVGSRHDASMDGPAENLPGTPVMEDIFEIQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHX7</accession>
    <name>A0A2R6NHX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHX7"/>
    <dbReference type="STRING" id="98765.A0A2R6NHX7"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="331" mass="37780" checksum="4B37F733B705AAE1" modified="2018-06-20" version="1">MPRTNYQLENEDHLSRRDGERSLEVPRHETLWFDDGSVVLIAGNTQFRVHKSVLACKSVVFQDLFTVPQPDDAQTVEGCPAVHLTDSAEDLEDVLDVLYHGLRYKSSNDPTWRMVRAFLRISDKYTMDEIRKEALYHLNIYAPDNTEDWDAIFTGSTSCISYEPWEEIDIANNTREPDLQHIHAVALYNCCHLPTKTLILGGTDMYSDARIELSRDDLVACVTARERLRIATSDILKQALRCNLSYTCTGSNCFTARNSAIHSWRDMDLPLYDPLAMTEVDARTRYQVAGVCEPCVEVLVGLHQTARQNILDKLPTYFEEELEETDVNPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHY1</accession>
    <name>A0A2R6NHY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHY1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHY1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="108"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="203" mass="21705" checksum="F286FD0F8ED724FA" modified="2018-06-20" version="1">MAATGCQASPPCDSGDGRGNAICSPYINPFSVNEYFWGTLLGIEVSSPNVLMADNVEMWDFVDGCSEPQTNVATCCASLDDGIGVDCDGPETNLPPIEDPSYDLPEWWTVAFPCAVDVPERILSDVIVSYSPSTATPYECALTCEAQGYYFAGLEYGDECYCGTGYSGGIPPTAANVSDCNMRCAGDYIYACGGSWRIQIYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIA1</accession>
    <name>A0A2R6NIA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001214">
        <property type="protein sequence ID" value="PSR72106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIA1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="26473" checksum="83B87D5A0676EB0D" modified="2018-06-20" version="1">MTDCRTLVPWEYTDNFDETKLGDALIFNNDDSQCTSVSSPYGLKKTYYTIISDGQETHIYRGNGKAGVIKGRSTHIATVSAARSRASAPWSLFRHKPVPKVMLDNNDGLWEKPAEGEVMDAEGSFAKSSWYGEERFEPVEKDTYLYDEKSSPLYSHGVQPGKKESQRKTNREMILRVPATAIPDDVFLIRFGRGASAATKASLKVGGQNSYDSYPCRLNMHRIAYINHRQSDDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIP4</accession>
    <name>A0A2R6NIP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIP4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5730" checksum="BA50582F38864703" modified="2018-06-20" version="1">MATAAKNATYGTRLTQRHVQAPELDLRWFPADTWETRGYFEGDSIASQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJI2</accession>
    <name>A0A2R6NJI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJI2"/>
    <dbReference type="STRING" id="98765.A0A2R6NJI2"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR72471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22119" checksum="FEB1C6C1222739C7" modified="2018-06-20" version="1">MTALRPMTFLSELAANASERNVGVLIYSGNDDSLNTTFGGVQGYTRKPSTPWFDDNGELAGVVHQERNWTYVLVAGAGHLVPQQQPSRAYVILREFILGNNRTGLVVNTTETVSVVGGESSSLAVDVFPGQSGIYMGSGTTQSTYTFPAATVAAWQSFMATETATPSGTVAGDLSSMGLQTSHAVSAPEASLVISGLSVFITLFIQWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJY2</accession>
    <name>A0A2R6NJY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001141">
        <property type="protein sequence ID" value="PSR72679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJY2"/>
    <dbReference type="STRING" id="98765.A0A2R6NJY2"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="239" mass="26883" checksum="D6DE60334B0F6E7D" modified="2018-06-20" version="1">MGPQQPQESDIGFLSPLQTHIAGPIFHEDLIDAWEHWTEQCGFSDVHKAVLTHRTRNMFSKDTLLGTVAYINAPCGHMRWTLLDWGIWMRIPNVVEALLECGADVHRGYPLHRAASWGDVEPLKSLVHAGADISLPNGHGRTPLHAAAYYGKAEYVEELIRIGGDNLDLDILDHYENTALDYARIRREYYDEMGVSTSGHDQIILVLSALQASSDGRRTPERSHERIEDLCMPGSFPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKC7</accession>
    <name>A0A2R6NKC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKC7"/>
    <dbReference type="STRING" id="98765.A0A2R6NKC7"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16872" checksum="29CD410B2C42D6FD" modified="2018-06-20" version="1">MDSEITDPTLAAELKKKRTFRTFSYRGIELDKLLDLSNEDLVHARARRRFSRGLKRKPMGLIKKLRKAKKEAPPNEKPAVVKTHLRDMIIVPEMIGSVVGIYNGKVFNSVEIKPEMTGHYLAEFSCSYKPVKHGRPGVRLFISFVTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKI1</accession>
    <name>A0A2R6NKI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001134">
        <property type="protein sequence ID" value="PSR72811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKI1"/>
    <dbReference type="STRING" id="98765.A0A2R6NKI1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35647" checksum="95307556AF49860E" modified="2018-06-20" version="1">MLIVPVGTPDDEVIKRIGSEKATLDFVGQLITFDPAQRPTAEQALTHPWLATYHDESDEPTCPRVFDRWRQIEQLETLDQYRDALAKEVRDCRREVRNMAALSPEVEGRIPAAIQEEVDLSTGGPEKGSPQVLARSLSPEERFSRRVSRKASLEPGATQPTIPESAVTFPGTGDPVVAYSRRSMFGQPSRTNSTYSIHRATNSEVVEGQGSSTISFPTATEYVMAGRHRTASLYTSGGDGGSDVGADVRRLLRTLSTVSIYESGEGLAGGLADVAPIGKYIVQKDRTGDEALPSEMPREIRGEENTESPSVHEDKDGSGGKRRFQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKI5</accession>
    <name>A0A2R6NKI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v11256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001126">
        <property type="protein sequence ID" value="PSR72889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NKI5"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="675"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1543"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1756"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1756"/>
            <end position="1772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR72889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1798" mass="200277" checksum="B0F09FC7F2626B57" modified="2018-06-20" version="1">MPQNAEATAFLVRISELPSGPGVSLDAALQPSLDDEATLRKLFAQDKTNSRLSDPSVGLVDIFDAPAAIRTTRARIIANEEDLSKRYVMPLSETARRKEGSPSMVESLEEFKKNWAIFTEGSLSQLADWNNVIASGGAVQACLTPVPDSAKVSKRALRKYFHSQAFPTSDVDLFLYGLTPAQAEVKINAIYEAVRDSIPWDVTCIRTKHTVSIHSQYPYRAVQIVLRLYRSPAEILAGFDVDVPCCAFDGSRVWANPRAIVAMMRQCNTIDITRRSPSYEVRLSKYSSRGFEICVPELKREDIDPTIFERSIVRIQGLARLLVLEKLATALSRDNYLDSRRALRGRPTRPYDWRRYATKKYKGDLKANADAGLELSDYDVISLHIPYGPGWDARRIEKLVYQTDLGMNSPYNPKNKDRRLHRHPAFFGTMEECLADCCEHCTQPKDDEERTLQEQEDQSYIRGRVGFMVEDPGRQSISGSFNPIDDGEWAEQAYMGLTEKFFFAIASHDKAAVARIVEQGADVDRRDHVGRTPLQVAILSKAEDIACYLIDAGARMTSRLVDGRTALHLAAQLDLPAVAKKLLERSAVNAETAKAAEEEAKRQKEIETEDDMETDDGASDGSDSTMRDSSDDDWSSETDDKKNPEDKSGDDDGNIPEDEEDVPDVFELDVKDWDYAFTPLQYAIVSGSVSVVEFLLASGADPKLVTQAARNYIVRYSHPLILTAATNDEDKACQIVEKLLAAGAVCSEADNQLFSIFHRMVCSGKPGLVSTFLKSDPSCKAVLSVPWMDQWSTVVFPIVSAIRSGSYSVLALLLAYGTNVVISQEDFQRARDLKIEMNQGAPQDFLPCVSMPVAAAIGQYDEVVHLLVALGAEINLPTPDTSRLTSIKDGRMTYLDYVRIVQKKASENIRSAARGSAPTSMPLPFLNSPRSSHPPLAPFAMLNPPTVAAVGRGGILSAGVAPSLGSGGMLKLGLAAPVAVPKWKSELLRIISECNDMQRKNFRPFSYNNSVYADEIKTYFQEVETLFSSNAGKSAAELTPADDISMLQVDNMWLSRIHNSPMSYQTPFNPVIKTPYSFHRLGRQEGHIGMHSNLTALYEELYEACWVGDHAKIQQLCLPQTSSKIPDTPLQISVHWGDNWQGYTPLFIAISARRWDTARLILAIASAQYDPEETKAQKFETRNINLDNESDDDDDDMDDDMEPEEEPIMNFVDIAKRPSAIHTKIRPSYMLDQARGPCPVKNGVSYHTPINKAIVEDDFEAFTQILGLYDHLQDTKTNGANFLTSDVFHQLMLHDRPPMLNEFIRRTGLGIVLKSETGVDQEAVPDNDSQQAYLGLNVHGKKRKDLAAKNDPSAPNTYVTSEYIPMLWTAAQRGLIGVIKYLASDQPLAAYRFYASSHSDEWAKRLQRMPDLEAVLPGKLGWAVSSLNESVLTAAIIGNRMDSLETLFSLRPTEMENALHIRHRTWGFNNIMAVARWGGEPAIFDFLLGKRVSPMEIDEQGRNIYHMLCNLSGEKSTKLLKHVLHQLPKETTEFMLRQQTKNGRNTPLHIAIEERRVAVVRLLLDAGANSYLQRDCDGAIPLQIAVSHCLPEITRLLAAAGPAEALVLEDGVGNTPLETASREAFLGNLNAITASILTPQGLQPQWQIKPFDVSNQEKDLVRYKATLETLLSEGRLINGTKLCKELLAFADRLERKIISEKNAMEENKKGEEDAEQNEPKDVADSRATFQILMEAIASRPCVRHLVHLSDVHESVTKGLEQHAESKEHRTDKEDEEEPAQEPVTHTLASDYNQGMPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKU9</accession>
    <name>A0A2R6NKU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v11119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKU9"/>
    <dbReference type="STRING" id="98765.A0A2R6NKU9"/>
    <dbReference type="OrthoDB" id="5420143at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015307119" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR73015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="194" mass="19486" checksum="C534D94418BAF252" modified="2018-06-20" version="1">MMRYTLALAFLALLPAALATISIIGPSASSYWVEFSNNTITWTFNAGDPTPVDIVVINPDSATLNGAFFAARFVDVSVETVTVTDVTLNVGSNYQVEFVNPSNASQVYATSNTFDVKPNGTAPAPTASAPVSSSASASGSSSASSPSGTSPSGSSSGAPAPSNTTSGVTRSYASADIFVVLVACGVASLAALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLP9</accession>
    <name>A0A2R6NLP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001090">
        <property type="protein sequence ID" value="PSR73279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLP9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="93" mass="10813" checksum="C150EBD804982B29" modified="2018-06-20" version="1" fragment="single">FQTSRCSHLYLRMSPWSMRKNLHGRSARIGWFSSIPEKDRRTVVTVLTRESRSKSLFPRNTCPLFARAIHSCQGLRPNARDLTKFVVWLCSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMG6</accession>
    <name>A0A2R6NMG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Muskelin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMG6"/>
    <dbReference type="STRING" id="98765.A0A2R6NMG6"/>
    <dbReference type="OrthoDB" id="10052615at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052456">
        <property type="entry name" value="CTLH_complex_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15526:SF5">
        <property type="entry name" value="MUSKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="70046" checksum="E029F9BA5D223250" modified="2018-06-20" version="1">MVYLFGGWDGQKNLDDFWVYDIQKEEWSMMHYATARERNGPGPRSCHKMVFDNKTGSIYLFGRLDEPEGGAAGGGSVAAVASASHGSGTTAPSSSPVFTAPRASAGSPPPAVAPGSTDPAPSRTWPLNCAEFYRYHTSGLDSGKWDLLYFDTSASGGPPLVFDHQMVMDAEAQVVYVSGGRVVDGDWEAIKYSGLYSYDVRANKWKMFQSDPSSTHPSIPSRYGHSMVLDHVTQTLFIFAGQRDEKYLSDMYAFHIPTSTVTELFPNFTAAGGPEPCFTQRAVCDPELREIYVFCGLSRNRRVSRTAVLESDAPYWIYRYERPERPGKWTKILPCETSPTSPSPLPVDTPSPLPRYAHQVVYDPLKKIVYMHGGNAGLESEILVHSYDYDGSARDRDRDRDGGDDIRTQSPGAHREVRSPAPHGGEGSDGEKENRLDDFWRMKLIRASPEDNIRRCRYLIRQQKFRELCANAPPLKALTYLQTDVSSVVDHSDAEETRVFRSLLSHLLIPSAVTISAPATPPVVKPYQGGSPMKTTPDKELEEDEAMTGVLASKSGGEAIDATRDLERPLVISMDRDPEEKDINGGIPSSAEQFKQREKLFEMLMEYINEDAKQPDRDLMRLINVDGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMI2</accession>
    <name>A0A2R6NMI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMI2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMI2"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="121" mass="13771" checksum="9111A89327302420" modified="2018-06-20" version="1">MTLTRLQFYTACKAFLDSDDSNPASDAIFKRYSEGWSWKEHDLFPGLGYLSRSVLLLGDLRDSRGYSAQDYSADLHVEVEKEDNASAEQSSEEVLTCRQYVVYSPTFQVPALYFNVHRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMX0</accession>
    <name>A0A2R6NMX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="9">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v10420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="9"/>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMX0"/>
    <dbReference type="STRING" id="98765.A0A2R6NMX0"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="480" mass="50511" checksum="3521EACDEB2F3B39" modified="2018-06-20" version="1">MRFKREFWIKASTAMKLSTAIQVILTFIFAQSVHAQAGLWAQCGGIGWSGPTACVAGLECVVENDYFSHCIVVTTSSASSSVAPPSSSSSASAPSSTPPSSPASACLTPSTVSGFNNSALPNPFTFNDGTPVLTASDWTCRRAQISALILGYEAGTLPGPPQTLTSTFTQSGTTGTLAITAANDGPSITFSQTITFPSGTAPAGGWPLLIAFEGGSIPVPSGIAVLSYSNSNMAQQNDATSRGLGLFYNLYGSNATASAMTAWVWGVSRIIDVLETTPAANINTQKIAVTGCSRDGKGALMAGAFEPRIALTIPQESGSGGDTCWRLSLYEQNSGSDVQTATEIVGENVWFSTNFANYVNDLSSLPFDHHLLAAMIAPRPLISYENTDVVWLSPLSSFGCMTAAHTVFQALGIPENHGFEQVGGHAHCAWPASLTPSLNAFFDKFLLGQNVSTDEWSTNNVFNGVSWNASDWINWTTPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNK3</accession>
    <name>A0A2R6NNK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNK3"/>
    <dbReference type="STRING" id="98765.A0A2R6NNK3"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="34116" checksum="628A7E6D21DC8308" modified="2018-06-20" version="1">MRTSRTFGRLVWYHVPLRVGPAPSRDPKGRITMPDDPEGKEHREREKAREVRRVMAEKRMALDLIEGFAVATKHHLRGEMGIYYEDLYQSVKPLHNHPKKHQIPVIVTAEPEETVFASEPPTVSPTEAAAVNIPPINSYGATLSSHRGHLHHASMSSFSSCSTEDADERQPLLPSNSPVHDGVMSGIAGDLIPFSGLIASIARFFTRTREVKHEVEAGVNIHDAVRHRSMWTHTKHRPKIAGGGENVPLQVVRSLTSWLSVMEERGNVPGTTLGGMFGCLAQFEDSLACTLLPLCLNSGFHLTDVHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNM2</accession>
    <name>A0A2R6NNM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNM2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="13240" checksum="820C7887B337DB43" modified="2018-06-20" version="1">MPLKSSNTVTTKIDQIQTALMQAYARLQDVALQDGVLYPINPPLKELQEVSSILLTAMTNTLFRNDHLLAKFPDLAELRTAMSELRKFVTTLNKGVKKASANRSLFSRRQSSETSSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNM5</accession>
    <name>A0A2R6NNM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001032">
        <property type="protein sequence ID" value="PSR74036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNM5"/>
    <dbReference type="STRING" id="98765.A0A2R6NNM5"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="494" mass="53778" checksum="30DEC7A760BCCC1D" modified="2018-06-20" version="1">MTLTSQDTATNSSSSIALKPAQPSPPVESSTAASLRSLYPRAAKAFLQRDIALTHSLLSSAFAQISPPAFAGGDELSIHRRKWDILRITLETTIYASPPTSEDPKAFPAPLRANQMQSPPSLVTSFHTRSLQLFTPTMPPTRPSAFFLPHQILVTLILSSLKLGCPEVGRWIIEDWLARRVPDMSEITQEGYTKVLELYCMQILPRLEEWEYAEDFLQYERELEPDLRNRMIETIRARHAEVVADKNIKAALRLQPNVVPPSPASSRSVSPASNSSGSSSSTQTATPLSPRPGVEKGKGKERARGTINGLTSLTSSSIMSSLAASSSTQSLASAETSRTVTPASAARNRSSHRNSKNRTRKEDGSVQNGDARTSHEKSIIALPRSTSSVRPPAVHAPSTLALVRSYIESTFRDASKSKMTAFCLFFVVFPLLSLAFRVRRRRVTVGGGGTADEVRRRLRGVQTGPGVGGGLMRMWAETLRAVSDTVKMAGRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNR7</accession>
    <name>A0A2R6NNR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v10050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNR7"/>
    <dbReference type="STRING" id="98765.A0A2R6NNR7"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="95"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="612"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR74094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1244" mass="139161" checksum="CF218786BF2AED0E" modified="2018-06-20" version="1">MQAFTPSPAPRRTVYERTAHEKTPPNFPRRRNPKPLVAGGKLASRFTTPVRGGSARASSAPDDVSLDEGMEIDEGAEVFERGLKFETIFAKSEELQVTFYAHLPAEVKLVLRNADFYREAYTGEVDTETGFALVASAERCFVWNYSQALTGTPTCYIFACPQDLVRLSMDTPFHILVPFGSSREPGLILMSPGGTAHFWDSLGMGLAGGEYSSKSSLGLSSEERVTKLIRADPQTYILSTSLGRLFRLVLTASGGKYRVSSHSFNRPPPTLSFSRLLPSFLATPNLAAEGGNISAVVLSDRPQDSSGSDVWALIDLRLQKWDMSIEGWEELTFDEDISTLIAPEIQARFNVSDDTEIDLELLDLSVNSPSELLVLVSFAGQDDNSNMDIGVQPRRIYAIVSLSYNVGILAISSSKKTQKVPYQSTSSSGAPMHPRMRLLSQGQIIAIQFGDTVVLCAPATEYTDRLELKSSSDRTFGVGVLRNGDENELIILTAATLMKVFVDNDEVAKFNTATGRANIIKSTMTQAILYGSHPENPLHFSFPPDIDEEALMSGAEQLSQAIMESEVGVVRPNHDLHSQMNSRKERLSFLIKFINDNGVLTKMSQRCRQRLATDAEKLYAAHQLWLRHNDSLAAGHKHSVLTEAVYILMNEAGEGHHEDLMRAFFRLRVQDIGALLPHVLEIVRRSSYEITHSLTDTIPQANEIILTILQSSTDYRNYNLGVYGVDLPMIHPWTSQLSVIDIVSELFESTATLVDSSPSEADPANDAKTRAKTQLPELAAALFASYQEQLQWLGSPVAAAEAVNERIRANLDEKFKQARPIILETLRRDGFSEEGFNLAEKYRDFRSLASLCHKETVYPPQDNPYAARIQAYINKFKENFTTELYQWYIEHGELRTMFSQEQNEYLDKFFAAHEYPSVSWIHDLGQGRYGFAAQSLLSEAEHAPELSSKHLMLSIGKLSYLAEVQETESAVDENVLDAFHDGLDFVSVHERLIDELRTALASVRTRQSIDVQVDTITKTKASRLPDRRALYAVFKQLVKRLLQGKALSVEDAADVLSLKDNVPNVEDYITALHLLYHAQVSPEMIEIILQLTNSAYSYLGTVDCRHLEVSGDEFIFTMSARILLNVSSIRSANRCFSWNQIRHTVDATDAELTERFRNTALYAVQQSMMIFNGRHMEGYMLLPQEALPTPTEEEVASRWPGMPADDVFALLRDYERESNDLAALQLEDVVDRVRELAAEEEQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPK7</accession>
    <name>A0A2R6NPK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPK7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="154" mass="18152" checksum="74336C60A187F422" modified="2018-06-20" version="1">MFDSQNGRNRHRGKPVMYDLTSDSEWGMLSPRPLARWSKRRPTKRALIIIACLFIAGVYGVRVWSGPHHAVQTHTTEVITHQQHQERPEKHVEENWDDRPKPPLFERYHVAEMALPQHHVSDPFASGRKFLWVENHVHGESGYRLRALYRRKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPS0</accession>
    <name>A0A2R6NPS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPS0"/>
    <dbReference type="STRING" id="98765.A0A2R6NPS0"/>
    <dbReference type="OrthoDB" id="2803523at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="263" mass="28804" checksum="D4595B756A98DC2E" modified="2018-06-20" version="1">MEESSQSEGIRWCKSEVVSRNLQGIGALSLDEYLATVQPRSPASQVLKDNTSNDDILDRSLALPKSHVGATVTERDATDSVKIEEVDTAVAQLDDAPNMDGESPLKAIYEDDFVKQIEQCCAEWRAGRVKPYWLIVSASKFGLATKYETPTAAGQACAKLAIDDGVLDYIRHGDGQMDPAVKMDLDQECFTGEPILPALANTQLWTVQDFFEALPRPFSEPVGNKTASEINSPAWLNTSIQGARGSRLVSNFIWTVDPHSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ87</accession>
    <name>A0A2R6NQ87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000974">
        <property type="protein sequence ID" value="PSR74642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ87"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ87"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1206" mass="137471" checksum="5625E9435285264A" modified="2018-06-20" version="1" fragment="single">MANICCHCKNSFASRAGLKSHRKGCKERDASLQSSVNQRNLRIKEGKAKIQQREQQDITREREQLREHLNQKLDLVHPDIAPDVQDAYMRSPTPQSAETTHILPPTRSGRIRKAPRHHKDYIPSTTTGVLHAHISQLLPPPPPASKPTQAPVESPPSDIDPEASTASVDPLPESRTVFETEPNEFGVYRMYGRKPRQDIAEEDLDNSLCDSPSIATAPPAIPSSPLQSFGRAVINGIGRIPDWFSPFLNATAFRLMHWAYTGSNQKSTAEIERLVHQVLLAPDFNQEDLRGFRMNREERRLDEHATASGGGFPVDEGWHEATVHVPLPKEKIKYKCEEEVPRIEIQGVWHRKLLDVIVAAYQDKSVSQLVSVPYQLQFQQPEGKSERVYTEGYTCDALIDEDAKIQSQPRNPEDADDVEYSVVPLMLWSDSTHLANFGTASLWPIYLYLGNLSKYVRSKPSSFAAHHLAYIPSLPDTIQDLYHSIYDIPATKNVLKFCKNHIIHAIWLLLMDDSFMDAYEHGIRVNCGDHVIRRLFPRFFTYSADYPERILLACLRFLGRCPCATCYILKTQVPDMGMKYDQKRRDNIRRDTTFIQSLLAKARKLIFEWGKPITSKSVESKLQPLSLQPVRSAFSLRLAKFGFNHYAMYAYDLLHGFELGVWKAIFTHILRVLYAEGGDKIQILNRRFRQVPTFGRDTIRRFSNNVSGMKKLAARNFEDILQCVIPCIEGLLPPTLDKIVLDLLWDLAVWHALAKLRLHTDSTLRVLEKATTYLGSSVRRFARACDDIDTRELPHEEAARGRRQTAKGKGTTTTGKKRKTLNLQTSKWHDLGHVPARIRSSGTTDNYSTQVVGPINYQQIMLTHRRLGPSQLSQGECEHKRVKRMYARTNKRKHEGQIAAKDHREGLLVDIKKRDEEVVKAQEAALSPSDSANLSRTHENSEPQPKRKRGRPRKKFFGLGPEDNDHLPQTSFDAHHHMSDSRRFGINIPKFLAENSEDPGVKGFLPSLKDHILSRLTGRDFDGDECTFSDDERGCLKIVDNRLFRHKVIRVNYTTYDMRRNQDSINPRTHADVMVLAPEEDIEDKNPDLSHPYWYARIVGIFHAKVRYTGPGSTTDDSQKIEFLWVRWFGRDLSAPGGFGKRRLHRIGFADADQPGAFGFLDPQLVIRAVHLIPAFHYGRTSAKLGPSILCQPSEGDEDWDLYYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQS7</accession>
    <name>A0A2R6NQS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v9390</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQS7"/>
    <dbReference type="STRING" id="98765.A0A2R6NQS7"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1290:FF:000002">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="12"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="13">
        <location>
            <begin position="169"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="251"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="562"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="15">
        <location>
            <begin position="677"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="751"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR74976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="842" mass="93546" checksum="187DCC14E917A7C5" modified="2018-06-20" version="1">MPPKAVSAETAELIELFKSIGLTQSKAAEAAKSPKSASTLKDIIEKKNLSTQKLDEKSGVLLAALAVHGSKLGGDEQEYAVDAILDGRIKSTDQVSAAAKYLEAHSAPVDQADFDKECGVGFTISPTELASQVTSYVASSAASGWANLGATIGALKNTDLRWAHPLELKNAVESAFTEKFGVKEAAKPKTKEPKKETTKAAVSSEQSNATASSSKSVFTEGFLGRLHKPGENPQLHSHLRDQHISATGGIVYTRFPPEPNGYLHIGHSKAIFVNFGYAAHHGGKCYLRYDDTNPEAEEAQYFESILETVRWLGFEPWKITYSSDYFDQLHELAVESIKRDKAYICHCTGEEIYINRGGDERGPRKACIHRTRPVSESLAEFEKMKNGGYKPGEAILRMKQDLESGNTMMWDLVAYRVLNAPHHRTHDKWKIYPTYDFTHCLVDSFENISHSLCTTEFIASRESYEWLCDALEVYKPRQSEYGRLNVTGTIMSKRKILQLVKEGYVNGWDDPRLYTLIALRRRGVPPGAILSFVSSLGVSTAASNIQAVRFEQAVRQYLESSAPRLLMVLRPLKVTIENLSEDYVLMLEKPLHPKVPELGTSVVPFTRTIYIDADDFRLEDSKDYFRLAPGKTVGLFQAPHPITCTSYKTDPTTGEVTELICRIENEGEVAPKKPKAFIQWVAEHAPTGSPVRVDETRIFHQLFKSENPAAVEPDFKADINPHSLEVVKGAMVEVGFWPLAKRAWIEAQKESKTRTDKALKSTEQTVGHTSPHDDTPKATSEQLIGKECIRFQGLRVAYFAVDKDSKLSCLEEGDEFKPIRKAGDIVVLNRIVSLKEDSGKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQS9</accession>
    <name>A0A2R6NQS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQS9"/>
    <dbReference type="STRING" id="98765.A0A2R6NQS9"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR74928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16299" checksum="C4421C52AC7A4301" modified="2018-06-20" version="1">MTDIEASPDIQSNSSKNAASHKSQSLSDLVFRALHLAFSRRTSAGASPPWRSAAFAKRLLTASLQWPPNTALRAITFVGDLVERDPKLEALLSTDDRSVNGVYRPELDDPQLCNPFGANFWELHLLAKTYWDKRVNKAAAKLLNFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQT3</accession>
    <name>A0A2R6NQT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000943">
        <property type="protein sequence ID" value="PSR74945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQT3"/>
    <dbReference type="OrthoDB" id="2742797at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="9494" checksum="F1735ABA042358C9" modified="2018-06-20" version="1">MAPEPRTHPNGQKRIKILDVAKVYGDVVEVPLSCYKGVKRGWHTLVTPAQVEAASNQFDGAGILEDIDTQWGSKPEGGCYHQWDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR04</accession>
    <name>A0A2R6NR04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR75004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR04"/>
    <dbReference type="STRING" id="98765.A0A2R6NR04"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR75004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11602" checksum="86F864A173397CC5" modified="2018-06-20" version="1">MARSNLRVGLNKGHPTTPIEKAVKPSHRKGIQSTRTKFVRSVIREVAGFSPYERRVMELLRNSKDKKARKLSKKRLGTLLRSKRKLEELATVIQESRRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRP6</accession>
    <name>A0A2R6NRP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9159</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRP6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRP6"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="263" mass="29563" checksum="2B82D246B85D445E" modified="2018-06-20" version="1">MPGGGDERNGVSEVSPVSGIVEPVEDYNKRSAFEPKLFTMAAHVHPTANTTPLILHVWPEKGSAISIDPECQLPFLTHGVRSVATFPSIAKYVLQLSGAVQLDVHLAAKEKAQTTARIAHLESELGNLVAHVFYAMSANWTGKTRPALVSILPIPQRYFIPQRLRESYRPRLEAALLWSPEAIEQEEEEERQRFSFRKVPKKNKKAAEKRHNLEREKVGRSIASYSSHEMTFGAAKVLNQARAVFDVYARLLGNNHFLYHDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRX2</accession>
    <name>A0A2R6NRX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA binding protein Ncp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRX2"/>
    <dbReference type="OrthoDB" id="3267800at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43070" checksum="4EC97C463DDA616F" modified="2018-06-20" version="1">MTTTFIDYTPSPSSQRSVYFDAPIMHIFSKEHSNDEDFVAPSPARTNQVPFNDSEAGEGSTRRSSVTIEPVTIPQPLPQPEYEDCNEPAEESALNATDYAETDKESPRSRHGSESTEGGAMLDSGYTSASPIARPSSMDAGEDMMPIPVVWTDNGSDVPQPSWKRTRDLAQSGDHKRSQSVRTTRTGGAGRDGTDEGSIRTTQSGRRSLNLSGGSFSNGAGMVGPAALPNDEETSMFRSRSVSADAGLTDKQKVKIGKAELKEGKRVVKVMKQEAKAEKKALEVAVKELTEIQRSQKNSIKEDAKTNASYAQALRVFHKEELEFFAARAKYERAQADQKGFEDAREASREHARMATEMLQEKNREVEWLRAQKAADDREREAKIRQLSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRX5</accession>
    <name>A0A2R6NRX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000925">
        <property type="protein sequence ID" value="PSR75125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRX5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="8753" checksum="8FDE9B0BAF6083FD" modified="2018-06-20" version="1">MATEATTKREYVLVSVMRLGEEIETEIFSSSGKSVQQSKSCQPSRNNKMSCTHSIDHSSVEDGEVHRADHAMAVILQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS02</accession>
    <name>A0A2R6NS02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">PIN domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v9087</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS02"/>
    <dbReference type="STRING" id="98765.A0A2R6NS02"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000057">
        <property type="entry name" value="RAD2p Single-stranded DNA endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="795"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="695"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1050"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="754"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1106"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR75607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1187" mass="132489" checksum="F83304664B186756" modified="2018-06-20" version="1">MEGKAMAIDSSIWIYQFQATMRDKEGRGLINAHVLGFLRRISKLLFYGIKPVFVFDGGAPTLKRSTIIERKNKKSGAVASHAKVAERLLAAHMRREALNQAQAHSSQVAIDKPAIIDENTVYLEDLIQPNPRTPVKITQKDQNESPPSSKKKSRWHDHDPYKLPEVNLDERIANATRSSVPDPRLATEDELRAFIEDMRPEDFDVNSPAFRELPTEVQYEIIGDLRLKSRQTSYKRLQNMLKNAKTPLDFSKEQIKNLKQRNSLTQQLFVTTDSIGKAHVEIPIRIASERNREYILIKNEGEGGGWILGIRDEGTRSKPIEIDQDPKPEVVNEDSEDDMEEVEIETRDTVDPDLREYRRNQALSALANRYSPKKLAPLTTKQPNRAKHSKPLFAPEDSDTEQLSASLVTEGIDPDLSIAIQESIADKEENDLRRAIAESRAEFSASASRLASNAGASSSRSQLHRAPPVTPRRDNVETLEDHLVLNSESDDADLYASPTRLETALSIANAGPRKATAQTDWTFGESTFGTPTLLLPAQTKKLPDTEPQAILVDSEDDLEEVQEIQPQQLPDSVPSVQVSVDVSTSLETLEPGPLPADDSDVDMEEVVPMIEPLIQSVSSTGDDSELSHPANVESSELSLTEIYPTEVRPTTPATSWTAAMLEQSDTRIHDTRTHVEVPATPPSSQPVLPLLQIEDDSSESEPENSWTRPQVPTHGAEDQVSPPEENWDAAQEMDPQAEEGEFVRFMSQVRGKNLDDVRREIDDEIKALNQQKKVAMRDSDDITQQMISQIMMMLRLFGIPYITAPMEAEAQCAELLTLGLVDGIITDDSDVFLFGGMRVLRNMFNQSKTVECFLLPDLERELSLDREKLVRLAYLLGSDYTEGLPGVGPVVAMELLTEFSGSDGLHQFREWWRKVQSGRDTEEDNRSKFRKRFKKRFKDLFLAEDWPNPAVRDAYYHPTVDSSEEPFKWGLPDLDALRDFFNSELGWDQAKVDDLLLPIIRKMGKRNQSGGTNKQGNLISFFDVPAGGAAPRKRQTYASKRLQQVVSDFRKQQAANAGNAAEKDTSDEDEDQTGHGDEIIKRPKKRRKASVEDRSDSTTTLGRGGKTTRGRGQRRGRGGSTRGGRSTKGKKISTSHSASSDQEIPEHATTVSPPPPLAVNLRPRPKPKPAYKSKAVTDAEGSGANDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTP6</accession>
    <name>A0A2R6NTP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTP6"/>
    <dbReference type="STRING" id="98765.A0A2R6NTP6"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="701" mass="77261" checksum="EAF207477359879F" modified="2018-06-20" version="1">MTTLNPAGAHSKKRKLADGEQDDDQTNQHDDAARPKAKKSKHSQVAPQQDTKKSRGLSQEYPTGFVHCHQCTKKRDATLVVQCTIKASGKGSRRCTAKYCQACLKNRYDTTLDDVKAAASLPLTKKQKEEHISGLGYHWNKKVLQIPKESAEDKALPGKAKPANSTKNSKAAKASGSSASGSKKTAKAPAKLKPKAAPQPVPRPVWTRVPTSLSNGDVETRMYIREFILRFATALAIPHNQLDELDVLSGEELGDATNSEDEDEESVELVGWVSEPCVKSIVLGLLHVIAGGAKGRNAHRETKALREAIQNVKSSGANLNKLWGALVSLREEEDFSLEFSDPLPPPASNTCRSTRSGGVDSILVATSAQLVPVIADLIEATMTTHAMHKAIDVGFTEEKNLTTNMQAAIKKETNRWKALQVTKDKARREQHNQNIRDIANAHYVAAIRSVSRFTSVGRDRDGRIYYMMTPGLAESHAAVQFLDGKDVKVKFGRKRGGLTENDRKDMVRWPWFVAVWGRKPEGALEAKPEKDEDCDDDDDKPEDEDESGESWWGFWQPEEIEKLAGWISRTSGLESDEETDDTPVAPVANGNGKVNSARGRRLTSGSNSSLSSLSSTHSIRDPSPLSDLSSDEDEEEHVSTDKQGRPIPNKRELGDLVKGLNDYADRLKWRIQRASREDTTTENSVRNTRKAAAIPTSRFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTW9</accession>
    <name>A0A2R6NTW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTW9"/>
    <dbReference type="STRING" id="98765.A0A2R6NTW9"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044325411" description="Ribophorin II C-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR76595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="26254" checksum="20540683F9D9E230" modified="2018-06-20" version="1">MSILSFCLLSLLVVSGTDAAKLSLQSPRFTISSSNATQLRAEPISLAQQPAPLTLGLTDVLKLTFQVIEKDEGKGVQPHQTFLRFYDKVSGEEGIQPIRVTPAGKAKFELNMARPPTSLPPTTSSDPLSVSLLLGSFEYSPVQFDMFDIYLPESQPAPQHPDEATFHPLPTIVHTFRAEQKLPPRPISATFAALVLAPWAVLLGLTVKLCRDVAPFTTIYKGWGIVRPPKKLIPSTPLAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU34</accession>
    <name>A0A2R6NU34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU34"/>
    <dbReference type="STRING" id="98765.A0A2R6NU34"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7106" checksum="B12F923B2831F45B" modified="2018-06-20" version="1">MPVPTTTTYSRLSFGSAGPPSPDRKKSTRKADRFVIQNGSKLHSYARDKAPYPFSYDRDVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU59</accession>
    <name>A0A2R6NU59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v8292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU59"/>
    <dbReference type="STRING" id="98765.A0A2R6NU59"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="8">
        <location>
            <begin position="62"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="151"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR76695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="574" mass="63507" checksum="96F7EAC2FD997FC4" modified="2018-06-20" version="1">MHDENKQRLQVPRRPPWTKNMTVAQLDRQEKDAFLDWRRGLAELQEQDSFLLTPFERNLEVWRQLWRVLERSHLVVQIVDARNPLRFRCEDLESYVQDVEGAEGEQGTGKGKRRSLLLINKADLLTAKQRRGWADYFDSVGVQYAFFSAANAAALQQARRDAEAAEEAEQEILDRAAELEEDNLHEAASSESSSDDEGSTSEEEDSSDESEHFMLPLSSEDDSEDARDPRAKVLSVLELEDLFVRVAPDLSNFTESAGQQATKLVIGLVGYPNVGKSSTINSLIGEKKVSVSSTPGKTKHFQTIQLSPTMVLCDCPGLVFPQFATTRADLVCDGVLPIDQLREHTGPTALVVKRIPKEVLEATYGLSIRNKAADEGGNGTITAEDFLITYAIARGFTRAGQGNPDEARAARFILKDYVNAKLLFCNPPPGISEEAFNEETWDLALKRAEGKKRAPVTRVGKGADTFVPANIQQSDSSVIKVTGHKSHTVDQDFFANDGTLAARPFTQGSARNGQEFTRSKLYPHQNAVADDGTPLNGRRARVAAVLANTGDVGTGKKHHKKIKRVKQRSGRGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV76</accession>
    <name>A0A2R6NV76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV76"/>
    <dbReference type="STRING" id="98765.A0A2R6NV76"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="34018" checksum="23E55B50C8B7C5CC" modified="2018-06-20" version="1">MPWSSSPDYIPGDDYVGLPPPHYTAGNSTQARANATILMLARNGDVDGAVRSVRELEDKFNHKFGYPWVFLNEEPFSDDFKRPDVHFHCEVDQDPFVYMEENDKLYGFTITMYEYHATIPTLWDTVKKFIADNPQYVAKDNAMAYQSDNGGDSYNLCHFWSNFEIASMDFWRGEAYSKYFEALDNTGGFYYERWGDAPVHSIAVSLFARKDQIHFFDNIGYEHNPYTHCPKGKGLWEQGKCSCNPERSFGASRLFHIPTFPHNFFIETNLELNLVHLPDYDGYSCMRQWDRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV95</accession>
    <name>A0A2R6NV95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV95"/>
    <dbReference type="STRING" id="98765.A0A2R6NV95"/>
    <dbReference type="OrthoDB" id="2685413at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="36325" checksum="935B365FE67D5705" modified="2018-06-20" version="1">MKVPRFRHISQFSYSANGGSPTQVYEFLSQNKGSMRIIHLHNVNWTFPSENISIRNLTHLDFHGTFPADSMGIADILGNGTQIESLRLQCVLECNASAQFRQYADGLPFLRHFAFSLVGYRVNDYDLFPAISEFLRDRTDLHTLHLTVPSADWAQRRLGYDATVWGVLPSLANLRSLSATLPKDVAAAVAMWLVPRGVQSLSLHSLTAGDPISFVSVSLPSTRRLYTDASLPIQQLRPGLPPGLKFIGLSQFHVDDVVAVIQHGFPMVRLARVDDAYYTVKNTENGVQLEEWPKSRTQYNVTEWLEWFGCENADWRDPSEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVB6</accession>
    <name>A0A2R6NVB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000794">
        <property type="protein sequence ID" value="PSR77469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVB6"/>
    <dbReference type="STRING" id="98765.A0A2R6NVB6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="444" mass="50004" checksum="E1A577856E6D4872" modified="2018-06-20" version="1">MWRMTSPTALIDPLLSHTHAGLLDLGERGELVARALLVEAYDAAVARTHAEINKDSTSISGGWCKAIHFIEALFQKDYAAAILDSHPDNTTGSTLREALKESIVHFTQWVKAADDHVVTTVAMAAAFTRGMAFICRNGQPQIDLLIPILLSNTTIGEKHMSAFLIQVKRRKGSGIYPISAKTLGFFKYRKTKDETRPYISLIMDLGVRVTLPNYAQLPAVDVISKAQKMARLRQVGASSTETQIPPRKTGSKRRGKGKTLDDTTPGVTKTPSKVKVNANPLPSTRNATKNKPCRYSIHAFGCSDTVYKVIRPEDRQKWQMLLMIDEFLADHPREETLPQVRQLKPFFTLGKECYHWFNDDLLNSDPSLAVPDEADQTAVFVREYQDEEEEEEEEEEEEEEEEEEDADAAIFSPMIVIQDLKQDDPFNEQFQLGRNAQEDFEMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVX8</accession>
    <name>A0A2R6NVX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000769">
        <property type="protein sequence ID" value="PSR77888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVX8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="11038" checksum="55FF762656546D61" modified="2018-06-20" version="1">MLPKIEYTLIVDIDCTQLEILRREDYKLCLVKRTSAQVNVIWQAVFPFLKNTFKWTADYQVFGASSFTPDASVEVETDSIPIESNLGKQWYGIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW41</accession>
    <name>A0A2R6NW41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000762">
        <property type="protein sequence ID" value="PSR78038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW41"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6833" checksum="09C800F4BFDA5FC1" modified="2018-06-20" version="1">MAQDVGSKFAPLSDKIKLFRMDPILSYYALGFKGTKPNHSFEDEGDPCGDLGDDVEPLLEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWM5</accession>
    <name>A0A2R6NWM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000740">
        <property type="protein sequence ID" value="PSR78469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWM5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWM5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="41"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="626" mass="69711" checksum="91E2D1547E1C88C8" modified="2018-06-20" version="1">MAIMYGWSNRRKLKLLVKKKTGRKALADIANDKSRSNSQGWPEMAKTLRDVDEEKIEDTKEDIDTLLVFAGLFAAVLAPFLVETYQTLAEDPGDTSVAIQRHMSTQLSSYMMMNGFLNSTVSAYPADDPSFVLPPFSLSINVLWFASLTLAVVTASFGILVKQWLREYMVIETSRGAKARLRVRQFRVTALDDWKVFDIAAILPLLLQFSLGLFFVGLCFFSWSVHPTIGRTTTSIVSAWGVFFFFAIIAPACSARCPYKTALLKKPMRALRRCISNYQITRHIYLGPVKESGAPMEDEDAATDTKGNVQILTAADAILLDDDLLATTMFDSLEDIKSPVEVIDFVVAAIQQRLPASGHITRPIVSLDLRRLPERTWTALVKITAQTLKRHRILRSKSTNDLEEWEKDAITILSTFYPSTFMSEAGDALTLCMNTALIPTCQLIGRAQNLLMGHKSLESHRSENIGPHQWLLYILELLRCLPSRPDIALPLNDVLQTIFRLVIAIPDLCDNTCHHDSSRNDLGQLLSAHADRLQNSIISVIGPILIEHRNRVSASVRESDPMYGDYESLTIAAGGALKNDCFLHDALPAAVNHHEATAADSMKLILGVIRNRQKQNIPLYAPGAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWN8</accession>
    <name>A0A2R6NWN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000746">
        <property type="protein sequence ID" value="PSR78377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWN8"/>
    <dbReference type="STRING" id="98765.A0A2R6NWN8"/>
    <dbReference type="OrthoDB" id="2802106at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="392" mass="44395" checksum="AF95A1B34BD43B92" modified="2018-06-20" version="1">MSSLAKIQDFDIDENLGRCRVCPGAKWTKMSNLRAHEKQPRHQGLSNIYAAQAARAKAQSPPAHDIDELDEVATEEQLEWDYWEHQTIDSSFNDGETAPPDPKLKFMESVLATLRHSAQNGENLAGKDLLNEHAVALEEAMQGLNIIEAALWPHDEAPLPEDGDEVEAEFEDALLSHIPSPQEIAETFFGARNTTDDAYFPYPNKAMMKTDILLSSPRLRFSRAQREAVLAWGRDLGAKNVPSLYALEKFQAVSLQAVGNPTVKIEAASGNILYMNDPAELLKKLYAHPKTRSKIHSLPELTPNKIKEVWQAEKWLYEVPDELLTPMIRLQNKDFYVQELVYCENEKWFIPERFFEYEGLKYAVGHAVTTSSLLLQSMQSACQTQTASWHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWS9</accession>
    <name>A0A2R6NWS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWS9"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="176"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38883" checksum="49D1765F0ECDE61E" modified="2018-06-20" version="1">MAIVKNGTVIYAEHPMDHIVSGVTTKYIEDDIDLDNVPLNGGVLIKTIALSSDPYMRYRMRDPSIPMFCPVIPLGQPIDNFGVGTIIRSEDPAYKPGDFVEGYINFQEYSVWPGPPEQQHGLRYLNKLDRAPGLPATIYTGTLGLAGKSAFSAYDVFAKEKSLESKVLFVSGAAGPVGTFVVEYARICNPKLKIIGSAGSAEKVEIMKQIGCDVTINYKEQDTAEILKEHGPIDIYWDNTSGPTLDAALKNMSHFGLIIACGAISAASNNGEGSIVRNFEEIFQRSITVRGFLYRRGESAKVLPEFYDKITKLVLEGKITSREHRFNGLREAGEALESVHSGKNTGKAIIVVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWV8</accession>
    <name>A0A2R6NWV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWV8"/>
    <dbReference type="STRING" id="98765.A0A2R6NWV8"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="358" mass="37971" checksum="F2C494EAF707B876" modified="2018-06-20" version="1">MHAIKTRLTQLLNVTTPIVGAPMGYPWSADLACAVTEAGGFGMTGAAFDTPEKLRETLGDIRKKLNVPSGQALPIGVGLIGWVLDRTEMSEDPRIPAVLNELPTAIWFAFGEDLGTYVRQVRAYEAKRQHKTLVFVCVNSVEEALVAANDWKVDVIAAQGTFIQGMLVVHNSRILDTGVEAGGHGSSHAPTLSILVSAILAALPNGPPIVAAGGIATGPQVASLLTLGASGVILGTRLLFTPECAYTPTQKSLLLKADLNATTRGMCFDEVNRTLGWPEGIDGRAIANGIWTDAQEGLDVEERILKYDEGKEKGEEERVLVWAGAAAGLTKEIKGAGEVVREIHDGALEALRTAATLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY28</accession>
    <name>A0A2R6NY28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000684">
        <property type="protein sequence ID" value="PSR79754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY28"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="184" mass="20818" checksum="4ABE86DB199B492E" modified="2018-06-20" version="1" fragment="single">ALPSSTPITSKTKGSQSPQVNTNGNIRWNKSHLPTSESQYPRYRNEFCPRFFGWIGAQPVTFNTNGINMVEGMQKNWDEILPDVPHQIEPRQAVRGGGLQTKQKLCDWRNSMALEAVGNVCEHMEAKIAAGKQSDTFQMPEERRKYIDELVNGDPKMGMPFIYSRRKVAPSGAVVRFLHPVWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY69</accession>
    <name>A0A2R6NY69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000680">
        <property type="protein sequence ID" value="PSR79879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY69"/>
    <dbReference type="STRING" id="98765.A0A2R6NY69"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR79879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="174" mass="19844" checksum="FDD6FB0586B8225D" modified="2018-06-20" version="1">MASCRLMSDYEVSLVNDNMQEFYVRFYGPAETPFAGGVWKIHVELPDQYPFKSPSIGFMNKIFHPNIDELSGSVCLDVINQTWSPMFDMINIFEVFLPQLLRYPNPNDPLNGEAAALLMRHPKEYEAKVKEYVQRFATKEAADAAADKEDEDGDEEMSDIGSISEDEEQPMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZJ5</accession>
    <name>A0A2R6NZJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZJ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NZJ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="9468" checksum="EEE67D94088B8DA5" modified="2018-06-20" version="1">MAAVSEKRTKKRPAASDAAPKSKKVHLDKKEKSSNDKGKKRSVPVTLPIIEDAGLSSDEGFEDEQGDEVMAEADDEGTFQPPKDPNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZK5</accession>
    <name>A0A2R6NZK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000618">
        <property type="protein sequence ID" value="PSR81444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZK5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7451" checksum="75462421419A8E2B" modified="2018-06-20" version="1">MSMVIVTLLKLTMRYSKSKHMSKHGNVDECSKIDDWRILGDGGAMRHSINQHHLILHFLQQMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZL2</accession>
    <name>A0A2R6NZL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000640">
        <property type="protein sequence ID" value="PSR80802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZL2"/>
    <dbReference type="OrthoDB" id="2986975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="78" mass="9132" checksum="129B940E0E5FD7EB" modified="2018-06-20" version="1">MANDLQVRWAPTREVSGRETIRLLRDFKDELFKASHNPQLLAEDDHLEELDETTKVWWEKMGRGGLSQIRVADMPILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZR0</accession>
    <name>A0A2R6NZR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000614">
        <property type="protein sequence ID" value="PSR81531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZR0"/>
    <dbReference type="STRING" id="98765.A0A2R6NZR0"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37354" checksum="27A674B068B3F909" modified="2018-06-20" version="1" fragment="single">YPVQTPPNKRINLHEPLSSPNNIDVVHAIKMGGVNERLITRHQLLVVTETVEFVSIPRRSFKDIVAPFQPELRQFSLDTSPRSHAFLQIRIASTDVIGIGTFKTAHPGKLTLVLKLEEPSSACGGSVSGYSIEKDLDDIPSSFCGAEDLPVVVKRLYHQVGRVTRGRIDMDEFTKGCYTPADELQKLSIEANTIYWAIALHGLSHDFIHRKLHSLPADQQIQIPFTRFVNAGLALAHGALPSKPLPSSATTTLRAVYLVEEPIVGRDGEAEDFVKLIHNSSAVPLISEKDKQWYDLALFAACHQHIQYWKTGGIAYVSDYQGSVLKLLVVDSNGNSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P156</accession>
    <name>A0A2R6P156_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRN6 K-rich C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P156"/>
    <dbReference type="STRING" id="98765.A0A2R6P156"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="2">
        <location>
            <begin position="316"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR83106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="455" mass="50088" checksum="24EED8947121FC58" modified="2018-06-20" version="1">MLLLSDRGSLHRTDLRFSEEGRDQNSDTEPQIYEWPAEVRQLAEDMEGSRWPPGPLSGRAFSEVDMEPVYQSTVTLLFFGPVLSVVKGLFKLDKQDQSSDQADDVYETIDSMHSFWQNLDVPVEHVLTTFDVAFRAGEEPNSASRADFFTKSVLNSKRGYRALMQGRIPTEHISKQAPWHYNLTPSLRRLVPAISDSPGETIQNLRRYDLQSDDYRPGASISKEIEAREHLALDLALSKDVYSPHAIQLIDPYATLDEAFETMSRATEAMSIGIPEPPPVQFGFLRPVSGGGADHYGKVKDGGEDGTNCPLGVRLLLKEWEVGSDPQTYTHQDPYDSSGPTAAVSRGINKATTEGSTELKSQFQPQRAPPVIVAAPMAPPAIVSTQLRPPLLAQSQDSRITPISHIGSQPAQFGASQDPSSQEIFMSSTQILPGPYGGRLVPAKKKPAKKRLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P162</accession>
    <name>A0A2R6P162_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P162"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="6852" checksum="55089530494E7B41" modified="2018-06-20" version="1">MDLWPTSTGSYDSISGKSKGKRKNKSEVQRTYPVVEYGAVGAANLYRAGKRLDWALVQGSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P182</accession>
    <name>A0A2R6P182_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v5887</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P182"/>
    <dbReference type="STRING" id="98765.A0A2R6P182"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015323587" description="triacylglycerol lipase" evidence="20">
        <location>
            <begin position="21"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="21">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSR83083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="456" mass="50082" checksum="44CE47E8A2BBDDD5" modified="2018-06-20" version="1">MLTLPLIISLILPIIYAAAAAHPRNHRQSISFTFGEEYRLQDDSGLSNTQPVFQVTPPDGGLQPTADSSHATTQTTAVLSARPTTVWRPRDPNAYQHARLRSLRLEEDEAVEWEQIEMLGPDVEDKHTLGQLARMTGNAYALPGEKNWYDLDVAWNTSFPYGWEDAADGFRGHVFVSPENSTVILSIKGTTLQGPTSKKDKFNDNLLFSCCCARVDFSWIFSTVCDCYANKSRCDSTCLSNALVQDSLFYNVGVHMINNITALYPTSTIWLVGHSLGGSLASLLGTTFGLPAVAFEAPGERLAATRLSLPLPPSSLSTHPPPQTHLITSSASGGGYHGSAPVTHVYHNADPIPQGVCTGFGSPCASAGYALETHCHLGKSIVYDTVGKLCWKVDVRNHVIRTVILDVIERDMADGWEEDFDGFLREVPKARVEEDCIDCYKWEFGDFKKKDLVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1E9</accession>
    <name>A0A2R6P1E9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000562">
        <property type="protein sequence ID" value="PSR83333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1E9"/>
    <dbReference type="STRING" id="98765.A0A2R6P1E9"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39725" checksum="69A1A1E88DF63E0B" modified="2018-06-20" version="1">MASQYSVDDIMSSYRDSYITPPPPLSPSHVPKVVVSTPDPYSSPPLISPNLQGRVPSRLPAGTANFSRPVGPPQTTPDPSRARPPVPGSEEQKRQVLMRHTGSQPNSSFSSNAAPRPNANLTAAPSRPTSQVESVYSNYSYYPYDGSPVSSPNPTQPSFPPQPRTGAPQQKASPSPTPDSSTNDPQSAQDYLQLGITHHLSNRLPESAVCFEKSAVLDGGCGMGMLMWGLAQRHGWGCEKSEERGFKWLRKAAEVAVGELEKGKQKGKEVEIGAVQSELVLAIYEVGQSFFRGWGVEKDKQMAVNYFRLAARLGDPDAQQDLAFCLANGKGCKKDKKEAAKWYRDAVAQGVSDIGLAWIYKEKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Y4</accession>
    <name>A0A2R6P1Y4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Y4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6807" checksum="753C64BC55BC6E4D" modified="2018-06-20" version="1">MADCHARINGEKPAWIKLGLVLGHPPHDTNLERLNIWEESLRLRHPTLARKRARWCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Y7</accession>
    <name>A0A2R6P1Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Y7"/>
    <dbReference type="STRING" id="98765.A0A2R6P1Y7"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="387" mass="42866" checksum="56A53866A6C8809B" modified="2018-06-20" version="1">MASSNRRTSSHAQDPWVLEQPYNDDDVLNRRRPPPRVEFALYSSPSEPFDPRTYQYHSGNSGYSPQGHPHNSLHNAMQAEFSPRTPPRVSDPAVHDLGGPIELSPDSSPLEEPWSPSPLSSLGSRGSSYRYSPVSPLSVVSSLSPPSSPGYTSSHQRYARNDTSTHNRHYYSSDDEPMHGPSDEEPPQHTPSPQPSPPTRLRSSIQNMHTSPIQSPSRPSASRKSPAFSSRKKNSSPTPAVAASPQGPPRIRRRVQQVKSIAEIPEPDGFTCPVCKRPQANKRLPDLRRHIKTHFQVVKEEETGPAWICCGVPVAHAAEYGITDTSKAFRWAYDGEMMIRGCLQIFSRRDTYRRHLKDSAKNHPGVHCVGDPNADWVPGNKIASGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2C7</accession>
    <name>A0A2R6P2C7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000535">
        <property type="protein sequence ID" value="PSR84397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2C7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR84397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="132" mass="14236" checksum="A85048859DC09347" modified="2018-06-20" version="1">MTADGVVAIIQALTPILISRFLLNLRQLGEPENGTEDAPDSRLSIPGFRIVTLTSIVGNMGEELNRLGTEEDAGVGMDSIIDEARAVVLAEGASWTEEIMESSLEDRCTTGNHQVQQVFFEMAPALSVLTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5D5</accession>
    <name>A0A2R6P5D5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000531">
        <property type="protein sequence ID" value="PSR85584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5D5"/>
    <dbReference type="STRING" id="98765.A0A2R6P5D5"/>
    <dbReference type="OrthoDB" id="2747626at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF25">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="79"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR85584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="315" mass="35888" checksum="0A61C6CE5F228EC4" modified="2018-06-20" version="1">MCTLPETHPLQPLVHRAAKHYPRKHRSALHELAHIYQLRPESIETITPARFGPYWKARHEIELAEDKDAARESEKKWRRRDGIRVYTDGSDVDGGVGAAAVLYKPGRRQVKVLQHHLGPSSRHTVYEAEVVALILGMELVRQENSVRSVSLAVDNQAAVTSSRSAKSAPGHHLLDKYHQLQAKVKKKHRNLKITVRWVPGHMGIKGNEVADEKAKEAARGSIEVRRPIPAALRKALPQSVSKLHQMRTQELKEEASRRWRNSPRNTGSSSLDYLADMRQFSSNYAQDTPPFRSIYTRSGKRKPRPAQLVKRHQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5E8</accession>
    <name>A0A2R6P5E8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000529">
        <property type="protein sequence ID" value="PSR85630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5E8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="110" mass="12496" checksum="1F63F86E15AA270D" modified="2018-06-20" version="1">MRQDSQILALASITPLPLSPSFPGAMELDHWLCFCSVTGPRISFLLWQGLLNQVNPSKTRWNARCGKKHESRFRESNIILHNHRYAFIDSTSENLSLPQQPFPANIMAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5I0</accession>
    <name>A0A2R6P5I0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v5319</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5I0"/>
    <dbReference type="STRING" id="98765.A0A2R6P5I0"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="108"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR85843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="347" mass="38180" checksum="9F66441A9A2019D4" modified="2018-06-20" version="1">MSLSLKQVAEHNNTKSCWVIIKNKVYDVTDFLPDHPGGSKIILKYAGTDATEAYEPIHPPDALDKNLSPEKHLGELDTASASQIQAVRDTREKTEDELRTEREQAAKPPLNRILDLQEMEDVARKVLSHKALAYYSSAADDEVSHHENGRAFSRFFFLPRVLRPLSGCDPSTTILGFKSSIPVFVSGAALAKLGHPLGEANITKGVGQTGIIQMVSSNASLSYSEIAAARTSPSQPLFFQLYKHRDNAVAEKRVREVEALGYNAIFLTVDAPYSANRERDVRAGWAVEDMAKIRKESAAKASNSANEMPRKQSDLENIEEEADVSGTAGALIVNDDVDMTWKEPDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8M5</accession>
    <name>A0A2R6P8M5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v5241</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in the mating pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000517">
        <property type="protein sequence ID" value="PSR87150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8M5"/>
    <dbReference type="STRING" id="98765.A0A2R6P8M5"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR87150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="37013" checksum="4820708E5A34EF79" modified="2018-06-20" version="1">MGNCISSSDREAAQRSQEIDKQIEEDSRKFKKECKILLLGSGESGKSTIVKQMKIIHQNGYNRDELLTFRTTIYKNLLESAHNILLAMRKIGVDCVNPSNRANADRILDYEIVASTSFYFSEELAQAIFQLWKDPIIPQVMDHSSEFYLMDSASYFFTEAIRIGTPDYVPTETDVLRCRAKSTGITETRFGLGPLSIHMFDVGGQRSERKKWIHCFESVTSIIFCTALSEYDQVLLEARNQNRMQESLILFDSVINSRWFLRTSIILFLNKIDVFKSKLPKVPLERYFPEYTGGADINKAAKYILWRFMQANRARLSVYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8N2</accession>
    <name>A0A2R6P8N2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000521">
        <property type="protein sequence ID" value="PSR86949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8N2"/>
    <dbReference type="STRING" id="98765.A0A2R6P8N2"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR86949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="520" mass="57848" checksum="E5D145FDEFC3737A" modified="2018-06-20" version="1">MAATQIKLAQAPFNIPSADAVLRTSDNVDFYVHKVILSIASPFFNDLFSLIQPSINSDAKVIEEPIIISEDSQTLDSLLRLCYPVDDPVITDISLLGCVLEAAIKYQMGEAEKLVKVSMQPFVVTHPLQIYAIACRLKVEELAKVAAQSWKSQRGSVLNTANFSSTTGGASYVPEMAHITCGAYSRLIRYIRSSLPLANFSPFSQPETNSHGGTHEVIDDPVPSIRPELPLQDADLVIRTPDGTNFLAHKLILNLSSADSILESLHDPPEFVDGLPVVHVDIEGQVLNEILHLLYPLNHTEYEDMSMIWAILVAARRYKLSGVLGAMRRRLLNLASSRPLPVYFLSAEFGWTDVAQAAAKYSIGPDLELEYTSEMEYGSAEAYYRLLKFNHACRSSIEKIVAQHTPDTYLGQWKTTGWASLMGPKHLLTTLLSPIVENELTIARSALKCPNPSIHGRYYDDECYDTIPPDYTISIEEIVKKSESLETEIKNELHKHMIRDTSDVPWLGEASDLMKSDVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC71</accession>
    <name>A0A2R6PC71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbose reductase sou1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC71"/>
    <dbReference type="STRING" id="98765.A0A2R6PC71"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="41944" checksum="5450527B9BF896E0" modified="2018-06-20" version="1">MNSIDHGDISRHTGTHSSPEVPVQRAPILTNHPSRSITLPSPEFFGSIASGAHYAGALSPTHVEHSTSHLPHKRAPSLGADDPIVHETYRGVLEDVKELFCARPSLEIFQRRWRKDAVFEDPLSTAPTPTLFAHEFSLADRVALVSGANRGLGLEMALALVEAGARAVYCIDLPKEPSEEWQKVREYAAKVSGKEGQGRLEYISGSVTDQDGMWKIGESIGNKEGRLDVCVAAAGILKSHTDCLTYPAAQFRQVLDVNTNGVLFTAQAAGQQMARFGNGGSIILIGSMSGSITNKDHAWVSYNSSKSAVLQMARSMACELGPQRIRVNSLSPGHIYTNMTAAYLDSQAHLLEKWASLNPLGRIGRPDELRGVVTWLASDASTFCTGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG34</accession>
    <name>A0A2R6PG34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG34"/>
    <dbReference type="STRING" id="98765.A0A2R6PG34"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR90579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="22807" checksum="59380E2EEBC85E58" modified="2018-06-20" version="1">MAYREKDAIAPASELPTLGHVDVLNEGEYVDEKVGSLSSRDSLDDATDRDEVVLVKGEPVITTGRDVSRFLLDTRDDGDPALTFRSAVLGTVFAGLGAALCQIYLFKPIQVGVSTVFLLLLIYSVGTAWAAILPRATWVEGTRFARLAPILHFINPGDFHLKEHVVASLVASTAAGGSSAVMNFAVQRLPDTPTQQNLPTVSIFQGIKIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMW3</accession>
    <name>A0A2R6PMW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMW3"/>
    <dbReference type="STRING" id="98765.A0A2R6PMW3"/>
    <dbReference type="OrthoDB" id="2343366at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR93746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="632" mass="71611" checksum="CC86CF0C14953E5F" modified="2018-06-20" version="1">MVHLQAYHWSSFGSTNGISLELPAFPLDSLAITSLVKRGNTHLVGLDIASRTLKSVAFDITHKATEFTFKADKKATSMGDTKPTAHNSLIDCHHDVWTRFPVVPAVQRHTVKSSARQPRVLLFVSHQEPHLYERHFAELIVAFESTRKPVDQVLSSISVSGQTYRAFLKYSRMSVSCFKAGEWLVDILCLIPIHLAVARDNRFIPLKDGVWSPQLERSLLGATVDQVTESLTFGWYESIFQSYMASRVGSIAHFINDGYSKAQFQYSQSELCRRWVLFRNNFALSRDITGLFQSFQSSSTVLDPAANPSLFKSTLVIIIKDVVDSDKAEITKEFSLKFQRIVEVEQASNFITRLHEGKLAIIPWPVIESRQFYALFPKLKKILDKQALTHPQAGIFLQTMKTLMAKLKTNDWGSLDQNLASHRAQQLLKMLPSALAFGATELEPEYEPLKDFDNGTVIDAFDTGVKFFISAPDGADQARKQDECLVSLQTFWDKYKTRFEEVDVQWVKGLEGHLNELAQYRVGHVQKWLDINRSRFQANITEFEVVLRSFETLSVNLKSGLQLCKMQCAECQLFCLHSRHHDGPHNCRTSHMCPHNCHYTDEHMDTEESCGLPAGHTGAHMYVVICNTDSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN76</accession>
    <name>A0A2R6PN76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v4487</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN76"/>
    <dbReference type="STRING" id="98765.A0A2R6PN76"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR94059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="488" mass="52812" checksum="AB40A3C213E31C49" modified="2018-06-20" version="1">MAADTANGGLSQLEDHYKTFITEQDFAQIAAAGLNWVRIPLPYWAIEVRDDEPFLAKTCWTYFLKAIQWARKYGIRINLDLHALPGSQNGWNHSGRLGTINMLNGPMGLANAQRSLDYIRILAEFISQPQYKDVVAMFGVTNEPFAPTFGQENLARYYMQAYDIVRTASGTGEGNGPFISFHEGFMGLSNWVGYFTNSDRTSLDLHPYLCFNAQSADPYSARDTEPCTTWGPNQNASMRAFGLSTAGEFSNAINDCGLYVNGVGLGTRYEGNYTGGPWPVIGSCEQWTDYQSWDASLKQDIQQFALASMDALQNWFFWTWKIGNSSVTGKVESPAWSYQLGLQEGWMPADPRVAAGTCGNTAPWQPPLQSWQTGGAGAGQIPATFTSSYAWPPTSISGGGAATDLPTYTPTGALPTLPAPTFTKSAGGTVDAGSGWLNSADNTGMNVAIPTCNYLDPWIGNAAPPSPLCGAAARRDTVPDPVITPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNN6</accession>
    <name>A0A2R6PNN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNN6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14730" checksum="76B18F9ED40B48D8" modified="2018-06-20" version="1">MPLYVQLDRFLYSKLSLETAVSILTQSHIPKLSRIHLKLQAYDYSGNYLCYDELAVLTYLEQLDWGIFNQVIDSPSLPSKNSLVLEARGATLLISVMRGSAGHYGKGLGESLREIVKERLPLRAYAAVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2B1</accession>
    <name>A0A2R6Q2B1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000404">
        <property type="protein sequence ID" value="PSS01013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2B1"/>
    <dbReference type="STRING" id="98765.A0A2R6Q2B1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="512"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS01013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="651" mass="72903" checksum="7910785C6F1665E8" modified="2018-06-20" version="1">MADGASAIIGIVAFGLNAAHKVYEVIDNIKDAPTDVLALKHDAKQIASLLLQLQELHILDSAVVPLSVDIVVLRKLFENALGEVELFIDKVAELRRDGEIRVRKLQWVLKGGRSKRLRESLRSLKTSIIAVLAASTSQSVDAVQALAIRLVEAQEQSSSNMDVFKRDHASWVAQQVAEFASLRAAIEERMAVLAYNQDRLYCMFALSPSSGVVQPFPNPGAPTAVSTPVPDIPVSEGREASAEGQSHGQSTLAPRTSRRLTAKDIKETLQCESPCGCCCHDKRLTRATPYWGTSWFGNLYLPRSFFHRSLISCNVQTCRRTQKNRHIANIKWFFPLWFVAVDMKIRLKAFPVHFCLQTPRRVPRTSPIFRCIRRMDINDVRGLLVSGEASVNDVDEVGTPLQLLQKFDSQQQQESDIGFVRPIQTHIAGPIFHEDLIDVWEDWLESCDFSDVHRAVLAHRTRNMSLKDMLSGTVADINAPCRQIGWTPLEWGIWMCIPNVVETLLESGADVHKGYPLHRAAFQGDVVALVSLVHAGADISRQDDDGKTPLHDAAYYAQDRFVEELIRIGGDNLHLDVLDHYGNTALDTARTRREYYDEMGLSISGHKQIILVLSELQASRNGRRTPERSQERSAYIESVEDLRMPGSFPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5I2</accession>
    <name>A0A2R6Q5I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000392">
        <property type="protein sequence ID" value="PSS02527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5I2"/>
    <dbReference type="STRING" id="98765.A0A2R6Q5I2"/>
    <dbReference type="OrthoDB" id="5946233at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS02527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="242" mass="27941" checksum="ECC3EDF98C213F26" modified="2018-06-20" version="1">MPLLTQSDPDTENNGIANAQMLLCHQHDPSLSDSLQHKFKGNKGNIKPEIAWRLLRQTFTPGFEDLLEFGVSEGWYDPDNTLERLVFHYTFIPWLQSELDGYIALTNDSKLRYNRHKVLPHGQPIENFHHLDKYGTKDFSVKVLKCHLDEVRSKDALPYHLVFHLVPPAFKEKACQFYSVIGTPDINCDNVWQVYNTLLVHFRSIQGRDDIWTSIADRAAMPTVGDDPMGKEYMEVLLLKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7I7</accession>
    <name>A0A2R6Q7I7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v3982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000385">
        <property type="protein sequence ID" value="PSS03514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7I7"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7I7"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="286"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS03514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="50151" checksum="6AB5E34B7596D682" modified="2018-06-20" version="1">MGGVFCCCSDPVNFDGEVDLFHFDLHRAVGKGAFGKVRVVEHKKSKQLYALKYIDKAKCIKQKAIANIIQERRLLEEIDHPFIVNLRYAFQDDENCFFVLDLMLGGDLRFHLERKGRIEENVVKFWMAELAEALDYLRKQRIIHRDLKPDNILLDAMGHAHITDFNVAIHYSERRLHTSVAGSMAYMAPEVVGRKGYTWCVDWWSLGVVAWELLFHRRPFDGRTSEKMTNSIMKDPIKLPSNVNEICSAECQDFLRGMLDRNTKTRLGCRTRGQGIEDVHTHPWMSSIDWENIRNKDIQPPFVPDMKKANFDVSHELDEFMMVEKPLTHSKRKAHPDLEKMKPELRQLEEQFTVYDFSKNNRMSYYPHNQPIVTSINQDDEEPSTVLQSATNTLLPTATIVDRSQARSPSPDHDHSQAQPMAMTGQHIPRLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB68</accession>
    <name>A0A2R6QB68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB68"/>
    <dbReference type="STRING" id="98765.A0A2R6QB68"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="113"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="225" mass="25354" checksum="0325CCEF09E6BFD1" modified="2018-06-20" version="1">MDKFVTVIKPSAKSLNGGKQDTKKQRSELRYKPYGDNKASEQLAEDLTEKERVKRFDTPAFKYYEHLISTFLEHITSMATGHQRGEGRANQKSYLESRSKKLEDQLPERNTNAEAKVLSGVRVYIDGYLNISTDIEMKRIVTLAGGEILHIASRATHILTSQQLSGSKTQKILTSKSKSKVHVVRPQWITDSIDAGKRLPERKYAAIKDATTKNLVDMLEAGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBF8</accession>
    <name>A0A2R6QBF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBF8"/>
    <dbReference type="STRING" id="98765.A0A2R6QBF8"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="35567" checksum="2DED841C41082552" modified="2018-06-20" version="1">MTLKVAICGAGFLGSNIAKTILSSTSAHSQCRVQLSNRNPERVHESVSTGLIPDQAKRLDPPRPVDVTRPETIRSAFSDANVIVSLVGVMHGTVEDFERIQWKGAENVAKFAQSTGAKLIHISAIGADSKSAIPYARTKALGEDAVLAACPTATIIRPSILFGPGDGFFGRFAQLSKVLPFMPVFGGGQSLFQPVYVGDIAAAVEVIARDNEDIRTLVDGKIIEAGGPDVLTYRQIIELVLRYTHRWRPIISVPYAVGTVQGFVLENLPINLFTLTRAQVEQLKDDNIVKNATPSAQYYPFKELLEKFASSRLTSVHEILPQYLPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUK4</accession>
    <name>A0A2R6QUK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000303">
        <property type="protein sequence ID" value="PSS15417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUK4"/>
    <dbReference type="OrthoDB" id="2683566at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS15417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121127" checksum="6C4B4CECB89CE143" modified="2018-06-20" version="1">MAPKPRPAYKGTSAPVAERNTPVAEQAVVPVDVPMTIDGQQTEEILVETEMGQEKGEKGGKSQRKVDDDSMDYVNQPEAETDHEQAKKPAAKKSKKGKKTKEANVGIAVDVEAAKIDAGKVRKDEVEKDKRAAFLGYVRIDLFKQSPRIVFGEWNERGVERGMSVKLANSYQTGSIQRFEEKNMIMIPVHAQRLVPTKCIRTLDNEEGLPMLGDIFEDGCAPTVVKPCGGQHRSAALHIMQTRNTKRLAELGLEGEKIQADLEDLEDGDAMQENEGASSSEVTQRTAEEEKARLDITKDAQKKLERIQERLAVIKRDLRLGGLWLAAVYDIAKLTESDLHQMSRNETNFVYMETKDEWAFGYLRRVHSLWSTVRYQPKTTALIEQGLRKDLAEMEDSPTGKFEREVMTGAEQARAKGVATQNIFRLPFAREMIMRLLSYGPYFRQQKDWMSMAWMERNMLNVSGGFISALVVSMSTMIDAVVVPTAYKDYKEVEAQLAEIEEEYRKSVKTESKSAKEQAQRKRLRSLREMRDEAMAVAVVPQYRMWTPALLNQLDVLVSELWDGGNIEYIGLPHPLHAKAMSLYAEKAVSLVKTYFQELLSTQKDMLSEADILVATHAPARMLVAFKTRLCETVPMPILTDKVFAAVVRRLGYLEPATREVALWIEPLNPYVISLSVSSQKDVSAGMLECLCARQYGIVESQREEARAKFSWTYFSSAAKGLIPMTLQLSIGGENVPPPRILTRPDLETLVGDSFFVSSDIPVEEKQEQYEETYAERLVKRKHRNMSEKEKAKERKEAEEEAKGKGKGKGKGKAVKKGASQKEAKDLAVEVAEKEDAIKAKGQEAPPLADFSLYESVVKRIPTGEWEGHLDQLYSVDLPVISLHIQARNGSLPRARKGGIAGVPQLSDIGEMVMLSSLPWERITAHGFGPMLKPLLHAALYEQQAIRVYRAELVRQGAGKQVRNLLADVLEQYTRPEFANNKDGTETWFGWWDEKLLGNVVQGKASKEETNMVEGIALIMERQARAKTYQDIQSLVSGLERSPLSRVGLKSKAPMSWEVSLAITGLARVRSGQRLMRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXN3</accession>
    <name>A0A2R6QXN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000300">
        <property type="protein sequence ID" value="PSS16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXN3"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="462"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="954" mass="107316" checksum="6C7493E2F6A84BAA" modified="2018-06-20" version="1">MPRATQTRQVPLPPVQVEEHCPRPPPRPGEDADFVREGTPLVMSLSCLLTVEHTNATVHPYVKQDIACAKSVPYHVWTGAILKLDKKKLKKWVSHIKRREWRNDPIIQEALIQFCGASKETSRYEPYEQIINRILELAKDQLSGLDSYPIEDIKITRNDPKYIERIPEQGVLGALRKPDLLFVRGAAVERVLSSTNARFRWSDILTFAELKAESGLLPVLNGWRVQQGLSEIDPDTLKPRAETRKGRSRAKASTSKPDPTGTTRALRGAVSVAPDGGSHVLASAPKHRAGAALHATVQEHCSTTGLKRARQHDDSESLHIAKKSSTESGAAKSDMVTLDATVQAGGYALEVASCTYGTRLFCLGTVMEDDKLSLWYYDAVGIVRTRETLSIIHDFETFAAVHVGFACCEPSQWGALPPVFKSPSSVAFSDHFPPQSLRGQTFDTLVQSTGEKVTITLEDPIFSQYSLVGRRTFLYAIKTKSKTLKKPLIAKFSYQVTTRRPEQDFVEIAREAGAGHLPEVHMWEDLWKMSDGARAAFHEKSDDYEDRVLRALVYTQYLPLKELFSNSCELIPEMVNQMLDCLHDLRYKANILHRDISCHNVMYEMQGDKVNFILIDFDYATQVNSKGEPRPCSTSKHRTGTLPFMAWELIQDMADRELEDYRPIAHLLRHDYESLFYLSLWCAVTMPVMRDRMKKKDIYRLHIREWESGTLKSIAIHKRVLCTAMGQIDKIAFPPECAMLRPWFRRWNALFSIAAMQLEKKRLNAFLGGGEDTLMDQETLGGSLSRDSIKNVLSGDFSDALWEEVKPEIPSEVSPSFENDNATFGPEDRSVNLAQPTDNGEQERLPEEPVTGASVALDVLQEPQHPSRMGRAKRVTKAKRTTITRTTTEAKKTLAARKLTASRKPAETTKQVNHVEKIHTKATPSSSPPREAISTKVAITKRMTTRSMVKKAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIM5</accession>
    <name>A0A2R6RIM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000248">
        <property type="protein sequence ID" value="PSS29871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIM5"/>
    <dbReference type="OrthoDB" id="2749652at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="217" mass="25122" checksum="DC9898629A3C6F95" modified="2018-06-20" version="1">MPSLSGKAKKAYTAAYTKAEYKKYIDKDGSIHGCVPDLISLEDSMLMTYTHLPSHDVESIFWTLTVLLLRARPLHADEERELPFITRKAWHILENHHIDSSPRGNVWHSGDGREFILHWNPDQWTAAFHPALSSLAPLLYKMAQQVRPEYCLFTYRPRPEHLHEAMRRLLLEQLVNMKDDILLDTDSRHDSDRKHSDDSSDTIQTAGRASKRSKTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLI7</accession>
    <name>A0A2R6RLI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000237">
        <property type="protein sequence ID" value="PSS30891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLI7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="121" mass="14196" checksum="471FD97B96FEDE4C" modified="2018-06-20" version="1">MREKKTYDELRYIRDGLPQWIWSKADPSKPDSQFWDGNTEVLAKEFKTHLDYEVEMVEGRLEWYAISGEWKGRQCSKDEMQEDLYGDVRIIACIHEAVELLKVGAFDKALGDRALVHCGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM39</accession>
    <name>A0A2R6RM39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000220">
        <property type="protein sequence ID" value="PSS31097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM39"/>
    <dbReference type="STRING" id="98765.A0A2R6RM39"/>
    <dbReference type="OrthoDB" id="3262759at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="68876" checksum="99865FD42C71DB26" modified="2018-06-20" version="1">MSVTSTILPSYPELSPWEMDPVPFNLKPPPPQDDMLDTPDFVAATLKHAQSTGMNPLYMWYGTNPLIIFDERMKSASLPFNSHTPPPPLLRACITEDITVLEQICPRGNTPLFKVCIGQDVRLLKVFTDRDWDEEFNPPADLPPAMVRFEREKYAYAHLLHYGICEKGTVPRCYGWFDLSRADVEHICALPRIDKDLAALKTLRRTPKAIILEYFPDAVRLSVTNITLDIADVALRALHTIHSAYVMHNDIHRRNILLLPDNRVIWVDFDSSTCLSEAGSKMRRQDLLGELEEGWGLFYNFLVRVSLLNDRDEQFCLMSFLLAAGQAYRLSALAILKPMDYLHVKGKAVEGEEQSGGSKSSNELEARMERAMRDAQEESDEDGILEGSDEEEMASGSGLSEEDEEDSDDDEEVEMQLGSEAESEEEDEDSASLKPPSKKQKLLQNPDYLPEHLFASAFSQNAAAASASSAKSEGKKRAASALPKKRRRVKQNAKDIVVGSRTIRTLPSSNTQTAAAAPRTLAPPAKVTKFIGRSLNFQILINPNIAVFSPPPSIEVKPFTPFNVELKTAKKGKNQLGLPRQRVTSAARRTALGWSKRSVGKTSTSSDKENVDQNMVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPQ5</accession>
    <name>A0A2R6RPQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS31975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPQ5"/>
    <dbReference type="STRING" id="98765.A0A2R6RPQ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="577" mass="61633" checksum="973E6B0F5DD856E7" modified="2018-06-20" version="1">MLNNSHFIPQPPALPSVPQQQGQPPHMALLSGHGNQTPAMNLLGGSGQPNMVPNPNYQLQLQQAAAQRRGHNHPPGHAPPQGMNPGAIAGPPNINGIGHPQMSNMNFQSQMMPNGQIRRVPSQPLGMNQAGNHLGGMGGMHPGPQMLSGMGGMPALNANQQAHFRNQQQQQQIRMQMQAQSQHQLSGGPGNMPSDLAMVNRQPHPSGNVGFAQHAGRSSSAQHMVPGLSQPQLPQSHPPNMQQPSFQNPLTLQHQHQQQPSQQQQQQHQQSQQTLGMSPHPPHQLSGGVLPANMSNPNPGQQAAAMNRARMTPVQDQMFMNFQNPQMTPNMTPRVQANSGGFQLSSSSTPPNQISDGSQSGPGGMGTPGPTALMATPAQAFEQMNQGGENFNRFNMHPPQNVPPPRPSSQQQRHPSTYQIHQPLQHLQQPPMSLHRSPRQPDRPIQQTPVQRPPSQPQTAQRQSPQQAGPSRTPRPPQASLPGQTALGTRLPTVPSQSMHGPPAKPPTPSVQGPSLAPRPPPGPSAPVGVGHPSGNGPPPPPGPSTASEAMPVPQHPPQLPYVNIQQNQAQLVISPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ80</accession>
    <name>A0A2R6RQ80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ80"/>
    <dbReference type="OrthoDB" id="2581931at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="163" mass="16385" checksum="EE8A4D6E150A64B1" modified="2018-06-20" version="1">MAMNDKDNTLAGARGVDVHPGVANPTSSSINSDPFAANFVTDPTTEDYGAGVDSNFKGGQQAARNFRESAGVVEGRPGIIESTNIDPLNESSNKDDGWANARSTGTGTNSTVGSTLGSATTTATSAAAGAATMASGAARMAYGHLAGDEATKQAGKEAVWGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQA0</accession>
    <name>A0A2R6RQA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000187">
        <property type="protein sequence ID" value="PSS32203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQA0"/>
    <dbReference type="STRING" id="98765.A0A2R6RQA0"/>
    <dbReference type="OrthoDB" id="2757769at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="454" mass="51552" checksum="5BA7A41C25829B97" modified="2018-06-20" version="1" fragment="single">MGVTLGQALLNFVITADDIQAPWEWPTWQLLTKSIFAPWTLPTEVKEYAPPSAAWTADTPAQVRAFVDNYIGMEDEKARLAFWVKKEDGNSKGRAAYKDWIGRESRKWGINKAVDQILRDAGCSQWQMTRRTVDKATKAVSYTLLPLAKTETKERTSAALSDLFFGADAIRADEDHRSAEVIEFIDDVLTITWDRYRKDVTRTGAIITNETVAVKNIWTTITKEGHKASKDDMLDYVSRAGRLLKALQKFDKQADKAFETEIKDHLDEIRKEGRGGSTKLSKSLKEAIKFLATSNEIAQVTLSIEQILEEMNDINLDALLDGLEDVEIGDLEWEEGIENYRNRTVEQAFAELGITQNSFPSFNQYCDANGCVDPWSAEWDHFLNDPQSVKEAIIPRWHQVIGVRKMVDMFFDQSPLLLMDQVGIGKTMQLVGLIAVLAYFIDYHDKHHKFPGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVT1</accession>
    <name>A0A2R6RVT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000149">
        <property type="protein sequence ID" value="PSS34141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVT1"/>
    <dbReference type="STRING" id="98765.A0A2R6RVT1"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS34141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="402" mass="46046" checksum="0258FC9AD913CA0E" modified="2018-06-20" version="1">MKGHDESMVQGWKEDVDTLLVFAGLFSAVLTAFTIESYQQLQDNPVQTTAELLRYIVVELSNRTLPAPTVDHRNILAESFQPSPASVRVNTLWFSALVCSLVAALIGILAKQWLREYLIKVSSSPQETVRLRQYRNDGLRRWHVVTIMAMLPVLLELALVLFLLGLLDFLWQLNTTVAAVITFLVGVSFLFYTVTTVLPAFFASSPFKSPQAWGFCKLLWSFRRLRRFVRPLTPIDVMFGDADMYHSLPDNWRERDIGFVRRMAGMLDHRALAWIYKSSLNEDLLDMMVPYISNLQPDEAASLAFEEIARKGECTVTVLIDSIRDNQPRIGLPKFIRRAGERGKRRLANMLLHILPRMDHNARHSGITAFDILFVLRTLLIESERAICEMSIHRRTNDKYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RW28</accession>
    <name>A0A2R6RW28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1742</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000140">
        <property type="protein sequence ID" value="PSS34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RW28"/>
    <dbReference type="STRING" id="98765.A0A2R6RW28"/>
    <dbReference type="OrthoDB" id="2803104at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="69"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="34363" checksum="EC90689B6BC112D4" modified="2018-06-20" version="1">MPVKREAVDPITLLLSPPPNETAEERVIRLQKEAEARKISENIDEQLRRESAALKKRNVLRMLLLGQSESGKSTTLKNIQLIQAPEAWQAERASWRIVIQLNLVRAVNTILDILSSEVPATPARAYDSWSMSPSVNLSLATADDSQWHDDPDFPLSTSPPSSPPLKPSVLPLSFTAAYAALRLRLTPLRRIEADLKLLLGAASDEVTEASLNGDHSTMVATPFDSGAYPLTHSPSRRPREFCVRSHDTWKDSVLKKTSTKTSPRRASLDMDANGVIAGCREDIWFLWKDEVIREALRRQKIVLEDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZI9</accession>
    <name>A0A2R6RZI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZI9"/>
    <dbReference type="STRING" id="98765.A0A2R6RZI9"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="33658" checksum="DAE9213F80439313" modified="2018-06-20" version="1">MLNSAFSENTSVATASGERKIYTIVVEEADFVTIYWLLKWVYGNWLLFKEHDNPKAAIEGVGAGWSAKSLDPSGPTDEWAWRTLGKNASFESGQDLTSINDTRSVASAASVEPALSPPGKLPLGSGHPTPSAQSSSSSRPRAISSSTKGLQNSNSTRPPPSPTRRSTGAVATPGNPNLLAPMSNPASSSTSPHGSKTLPLPPLTTTSTFPSSPRYPISPNKQRQRSRASGTTEPDPHPHPTLAPLPASALAMYQVAHRYGMPGLASLSLEHMMSTITPQSSFALLLASSIWDELHTLVEVSHLLSHGCTLRLNFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZM2</accession>
    <name>A0A2R6RZM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v1637</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZM2"/>
    <dbReference type="STRING" id="98765.A0A2R6RZM2"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="16">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSS35482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="155" mass="16656" checksum="D82CBE1C758D488F" modified="2018-06-20" version="1">MQYLWVDGVDQGQNVDLRVPPNNNPVTDVTSNDLTCNVGGTSGSGVSLSNGINTPNAPERMLSRAVTRDLFKVNFLVNPSSQLDSYRGTVRLVYIAKAPSTAASFDGSGAVWTKIYSSGLVDSSSQEWATDVVNANGGKRWIKHLNINLTIHISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZW0</accession>
    <name>A0A2R6RZW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000122">
        <property type="protein sequence ID" value="PSS35519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZW0"/>
    <dbReference type="STRING" id="98765.A0A2R6RZW0"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="499" mass="53449" checksum="1C0CDACAE82D3019" modified="2018-06-20" version="1" fragment="single">FPVRPTKDQQVLLDFVKPDLDTPRTLWSTKVTNLELRRRVDQFGTGLVKIAGLVPADSNVLLLLNDGIEFLITDLALASHSIPSFTLTSMSLLSPVLDSHPPTAIITHAEFLPNLLELIYDTHEGSHHTIIVVGEPKVKIARGLGQVRIFKWNDIEREAAQLEQVQVSPTDPKQVFTVSFYSTSSGELRGTQLTHENLTAGVAATRALLPLSGAISPLDTIASSHSMSSAFGRTVAYTAVYEGTNFATFASTKLVGTDEVASQDLNDLKSVDTYPVPSPTILFVSAFHLSALTSAILDHAKRSSFLYSLAWRQKLAGILEGFTTKQSLWDRLVFDAARMGVMGKGAGTVRGVVVSRGALETQALTPSRIALSVPLVNSYIHPLVSGPVLASHPLDLQVFPAEPASAGTSATDNYAFTYLAPVGPPSINIEAKLVGVDDTAVENGSDPIGTLMLRGPSVGIVLDSEGKGVEGEKESDWVETGERAKVLSNGTFKVASVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S001</accession>
    <name>A0A2R6S001_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000114">
        <property type="protein sequence ID" value="PSS35594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S001"/>
    <dbReference type="STRING" id="98765.A0A2R6S001"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS35594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="103" mass="10788" checksum="52D19634A52FC243" modified="2018-06-20" version="1" fragment="single">LLSAGETIPGFTAVPNDSQGGSTADWEKWILDTFTAVAHPISTAAMMRRSLGGVVDAQLKVYDTANIRVVDASVLPLQLSAHLSSSLYGVAEKAADLIKSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S432</accession>
    <name>A0A2R6S432_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS37013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S432"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="7025" checksum="73508E21FDF486ED" modified="2018-06-20" version="1">MRLLQRLEGSTQSFEVPVRFAAFYGRLKGVSARRSISIAPLLRRKSNVHSMDTFETWRQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S474</accession>
    <name>A0A2R6S474_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000082">
        <property type="protein sequence ID" value="PSS37094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S474"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="91824" checksum="E7043FE475EE6A45" modified="2018-06-20" version="1">MSASAIPTLSRRRVPDVPEDVDDVMEHFNDPNWDYRPPSPTLSTESIDLDRKGKTFSETSRHSTSDFDTESNAESTYVKTAAETGASKSQLWRTGTRDYEDDSPYPEVRAAVSNMDDPSMPVNTFRMWFLGLLFTVGATAINQILGLRSLSMTINTLAIQVAVLPFGKAFAYFLPRTRFNTFGYVWTLNPGPFNVKEHTVIIAMANMTWTTSYVLSVFLVQQVNYGQQLSYSYKILLGLSTQLIGIAYAGLYRKFLVWPSSMIYPGTLVSCSLTNTLHRTWGIREKSHISREKFFFIVMVCAGVWYFVPGFLFTGLSIFSWACWIAPTNPAVNTVFGSATGLGMGLLTFDWTMISIIGNPLVSPWWAEINIYACFVFLAWFIAPILYFTNTWFSKYMPISATAPFDNTGLPYDLSAVITDGKFDNDKYQAYSPLYLTTMNVLTYSVCFGILPATVVHTWLWYGKDLLRQFRSKLADNRDVHSRLMMAYPEVPMLWYGLLFVFCFAAGIAGIEIFPTGFPVWALIVSIIIPVLLILPVGIIRAVTNQWIQLSFISDLIGGYIIPGQPVAHMIFKTYVTWPAEQANAYLAGMKMGHYMHVPPRIMFIGQTVAVFVTAFVSQAVVDYILSHSPDACTPLATDGFTCPTNGLFADGAIIWGAVGPQRLFSPGQLYNPLLWLMLICAFLPIPFWLLARRYPYSRWRYVNIPAALSAAMYFPPATGMQFTSWFIGGAIFQWFVRRFHFRWWMRYNYVLAAALDAGVAFGAIFVFLFTSLPKGGLTLDWWGNTVWMNTNDAMAMPFTLLAPNATFGPTFAPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4F4</accession>
    <name>A0A2R6S4F4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1041</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4F4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4F4"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="198" mass="21887" checksum="788015F3CD2E908D" modified="2018-06-20" version="1">MRLKGTLLPFTVVRKYAAELIVAVEEIHRLNIMHRDLKLDNILIDDTGHLVLADFGVAKSFAERPLSRPWESHQSGASTKRQQAGGPREEGLNDTTVTSCGTPGFIAPEVHSKFYSYEADIWSIGVILHYLLLGRVSGAMLLHCCTKFQQITATVTVRHEPRDTVLQRTGSSNEHLGRGIRPRGKDRGTQSKVTSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S538</accession>
    <name>A0A2R6S538_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000046">
        <property type="protein sequence ID" value="PSS37386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S538"/>
    <dbReference type="STRING" id="98765.A0A2R6S538"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="69"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="324" mass="35311" checksum="306771D372B0DACB" modified="2018-06-20" version="1">MEIAAPIAWPTAKLLDFALGKSEVPTYKKAELKSFLQFHRQGEEPLRDDEISILNGVLELSNKHVASLMTPMKDVVTISADTILDQEAVDTLLRSGYSRIPVHETGRPLAFQGLLLVKKLSIYDPSKALPVSKFPLSILPEADPTINCFQALDYFQTGRAHLLLLSTTPGKEGGAIGVITLEDIIEEIISEEIVDETDRYEDNHSKKRATRLKNASVMGGCGLVSSLLIVWFSDSPHSIVEYRYNLDGSAGGGERTPLLRGPSIVESRTQSYVGTAAASPREDVYVRPPSQLGLKVYGAVELSNGESAQPNGESSALPDVQQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5N2</accession>
    <name>A0A2R6S5N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5N2"/>
    <dbReference type="STRING" id="98765.A0A2R6S5N2"/>
    <dbReference type="OrthoDB" id="3194584at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="37844" checksum="FAE53D7D374A43CE" modified="2018-06-20" version="1">MYTNEDKQYFLKFIQWELKMDPTASCITICEKLSEKAPHHSKQSWRSYWRDHREDVDRLLERNGTEMHRTSDASYPPPKTRCDSPDDYSIIEFQEDLEEASQVSDKESLGDIPDEDEDERGMGESGDFYNDSDRRMMARYIAARGEYWNELTAYTRWQPFYEKVGNSLRDLLWCQVLTFQFVAAVSKAQRSRMEGVLSQAWENLARKFRRRNGDIDIVMTSMTRKKERPQEPITGPIASSSRVVIDESDIIDLTSDSDSTSPCDDKGKQRDPEVGRFATGFGPTVPYSVRGAQATKRKLVAVGGYAQDFEHSGKRRRVGADHPYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6A5</accession>
    <name>A0A2R6S6A5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6A5"/>
    <dbReference type="OrthoDB" id="10580430at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="9774" checksum="52EB533014699AE6" modified="2018-06-20" version="1">MSKSSRKGKKHTNDSRQNSAKEAFVKRLKHPKARASKAQLTELTTELNTRFAEVQALSHTPTAPIQPVSHSQIEQESVRGLAEVLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6F3</accession>
    <name>A0A2R6S6F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6F3"/>
    <dbReference type="STRING" id="98765.A0A2R6S6F3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10677" checksum="E9BBC252891F9975" modified="2018-06-20" version="1">MQTRSSVLGKRQARPESTSLSISSFESDEPQIKFPITPESTPNSKRAKVALTVLDGDGNKENVPPFVNTIDPPSATRRSLRRTATEVASPSSFRSSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6Y4</accession>
    <name>A0A2R6S6Y4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000010">
        <property type="protein sequence ID" value="PSS38038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6Y4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="54" mass="5854" checksum="935CBE83AE430779" modified="2018-06-20" version="1">MSNPTPNSSLCPSFQRAVVALEPDVLGLCAEVVDLPLVMESIRDDRLNPPPGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDT4</accession>
    <name>A0A2R6NDT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDT4"/>
    <dbReference type="STRING" id="98765.A0A2R6NDT4"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="8766" checksum="94EE9E77EF337E6F" modified="2018-06-20" version="1">MHDTLKKPREIIMVSYAVRFPELAAKSKSVAGEVDMDPAQGTSPERQGYNGSRQIAATLGNPDEWESQFQARIEDLDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDY0</accession>
    <name>A0A2R6NDY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001348">
        <property type="protein sequence ID" value="PSR70580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDY0"/>
    <dbReference type="STRING" id="98765.A0A2R6NDY0"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20749" checksum="7FB163FD584C10E2" modified="2018-06-20" version="1">MSNWRLLFIVEGIPTVILGVLTLWLLPDRPEETAFLNDQERKLQIERMNRGLKADVGRTVNKKHITAAFKDWRLYGAGVLYFGANCALASISAFLPTIIKTFGFTNARAQLLTVPPYAVCAVVLCLTSYCSDRLQSRGVCVALSAALGGLGYLLLLTVHDNNHVRYFATFCITSGTYTVIGVVIAWCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEP0</accession>
    <name>A0A2R6NEP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001309">
        <property type="protein sequence ID" value="PSR70850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEP0"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051473">
        <property type="entry name" value="P2Ox-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784:SF1">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="538"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="614" mass="68036" checksum="840E5D91E258D133" modified="2018-06-20" version="1">MSSGFSSPADYLTVPHSLTPSFHFRTGKVPRLPVAERPSKVANQFGYPRPGIQSPTPALATAAHYFVDNNTWDAILDHGDFDDIVVGSGFCALAYVDEALKRDPWRKILILERGGFWLPTHFQNLPLPFKMVLGGPSETFPWTLSSITRNIPEVGFMHGSCPFFGGRSTFWSAWCPQPTLDLMRGFPDSMKRTTQSEDFWKDCKELLHVTPADQISNQIFGELQKDIDQKLTKALNAGRIRTADTTEAAPLAVGKTSPTSELAFNKFSTPGALLDIYERQRKLTKANKGRPLMIATDCIVQRFQTDENEGHVVRVLETSRGALCFPDGRTNIILAAGAIPNTNILLNSLGSMQTRAGSRVTGHFLTHIAARFPKNKLRYSRLGNESFHLKEDKLEIAASYLAGRDPSSNMQYHVQITAIHSPHPEQDAVDAGRECPDYAAAATAEQLEGSEDYIVLVCASLGELDEENRDSWLRRNPQDPDLTTNVKLQITLSEKDHSLWDIMDHATYDAIAAMADDEVRNLQYWHNSSGWSSRKPPVSEIRVPGIVHEGSTLYMGPQGDPAAAVDDRYRPYGCQNVYVTGAALFPAAGSWNPTLTMCGFAQDLARKLVPKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFT9</accession>
    <name>A0A2R6NFT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NFT9"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="255"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1111" mass="125549" checksum="C2424E7A5F48C2D5" modified="2018-06-20" version="1">MERSTLYNLSKNKSSDSLSDAESLASTHYSVPDLTQEMLAFDDSQLYSEYDATQAAGCSYGQPTEDARDGEHEPVGSGKRKRSASDALAGPSAAKVHKPSSEKYSARTLPDLDPIILAGHSWLNSRLAKFKLPWGVQWELARYVNAGFNDSGFTADRLEELKELCSHSNKTAPKVSDLVQRWRSPDATRRTNTTSLMKEISAKAPWAELDLEAEELKKQYVGCDTHDFYLQNEDWFGGKVHFTGKLKAEKPGELRLELDRPYLASSTRFSRRFGSERFIRIRMDLNTLHNTELNLIAYFSRPLIIFNRVYRAFYSKENSVFFIHTNEIISRKTTGLGIVSVDEPTAGASHTDNTGVSMLRFLDWHNNIDINSNQPMAKWASRFALGLSNSIPGINIDACDLHKIGDIDGCGYASADVFKALQSQFCWNTYPTAVQIRINGAKGLLVLDPERSSVTLDEKPQVSIRPSQTKISYPAGAVYDRARYTIDVLRSSRMSTPARLSEETIINLAENGVHIRIFLDLLKLSLESRVDRLTTWDGPQGLFQLWREVAKEGSIVSARLAREEAGSARAKGYVYEDRYADEGYEDEDDLFAAASSEHSTAWWEDPVSGCPSGLEDTVLYLLDAGFKPDSCQVLAAKLQDVAKKSLKSCAERFRVDVPMSCSGFVIPDPCGVLRPGEVQIKSSSRTLTDHFGQLSDIITGEVLAVAVHHTALRNYVDVIVVSTKGHIVNGETLARHIASMTGGGDYDGDLMQVFWHPGFVANFRSADKRFADEPASLASCLHKVNESVQSFRERVPRTTPYKEQILEMQSYLLGSLKNASLVGTYNKFWEWSIFKNGYDHDETLRLAYLFCAILDGSKTGVTVDPDQLRRDRAIYTDTSQGPAYKAARGKERKALVRTDRTNFPFLRRAPGLPTFIMEELQAEVQKEYGMQLRRIEERLPQTYRSLDQDLAKPWLTFFEKAKRRAAKKQMEMQYIVHQIEEHVRIVYDAWQSTIKDQTRGSLRFTELPIVERQDRLRKISRMFDSGPVDDESDGLYDEKQLRHIKASYAYYYDNQQECSRRGWTRFPWDCAARTLCEIKAEAVSGGQTKTVTQDFYSRFVIHGAFTSSDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG56</accession>
    <name>A0A2R6NG56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v12825</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="9"/>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG56"/>
    <dbReference type="STRING" id="98765.A0A2R6NG56"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="28"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="363"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="613"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="811"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="881"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1071"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="840"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR71311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1141" mass="127246" checksum="54FCBFA261573CE3" modified="2018-06-20" version="1">MKLRPDLLAARRWLYPLNQQRRDYQFNIVKRCLFENTLVALPTGLGKTFIAGVVMLNFYTWFPEGKVVFVAPTKPLVAQQIEACHKTCGIPGSHAAELTGQNSRAVRARTWQEKRVFYMTPQTLMNDLKTDNCDPQDIVLLVIDEAHKGTGDYAYAQVIRYMMAKNPHFRVLALTATPGGKPDAVQAIVDALHISHIEIRDEGSLDLKPYLHKKHIKQHIIEMSDDVRKVRDILSEAMAPHIKKLVSAKILHSHPSPVMLHPFSCNMAMQGLHAGRKGAAWAFSALQKLSGLARAMGYLLESTTNQCHICLTALATDDDGTTKQGKQKQNLFKSDPQVQAVIKELETQKSRAGGFSTHPKMDKVKTLLVEHFAQKRFDKEDADANGGSEELTGDSHVMIFVSFRQCVDEIVEFLNLESPLIRAVPFIGQGADKAGKKGYAQKEQLEVIQKFKSGQFNVLVSTSIGEEGLDIGEIDMIICYDAQKTPIRMLQRVGRTGRKREGYVHVLLSEVREERNWDKAHDNYEDVQRFIIRAEQLELYEDVERLLPENVKPECIEMEMEIEEYTREEPKAKKGPLPNAKRKPRNDDAMRNVPTGASSGFVSVKDLMLKGTKKRKKKGSALVEFDPHAGEDDSDDEEIEAGIFGPRRTQSMPESSKKPRQKKLHRSTTMATNQQEKHQATKSSRKKKATSIEDLTNNQLERVGTDDIDDREIEMGLSSAHLKLPSKGKRLPRTSTPPPSPRQRSKASLKHKPPTPGNPLPDDVIDLTVADTPIRISSSPDIPICDLDVERSVGSLTDGLLSSLGDSHLSHISEELPPASPDTSPSAHAEIDDASMSWLVDDDDDPYPEPMSFDDVEMASRHEVTSLTEDIRREDSLAFSSLPSEASWKLSPSPARFTKFRSAASSGSSSRNNMPPPALPERFEPTPLHSPPTPLEELFPEPTFAVRVPGKQPRKRTRIETIDSSPMAMPPPSQKRLQRQKSCSPPASPEPLKPKRKKPRFQDVVEAQKHNPWIDVEASHSGDELSQGGYEEDEAMSESDRQFASDFPETQVSPSYDQSAVYRRSLLTQAPGASMPHFANRPARGGRQYSLAAPSKARAPVEVSSSPPRHDSSDDYVFGSFIVDDDDEISYAQDSSVLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGQ8</accession>
    <name>A0A2R6NGQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGQ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGQ8"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="347" mass="39210" checksum="9E8F139359FF1E07" modified="2018-06-20" version="1">MHIEEHPKVSIKVPAHLSRYRKNAPPEAAGTSTSGLEYSANFLVPQMYSSLTRSGLFSLPPFQRTRLMLELLVSAREHTAGLIVMRDIFVPLASGTPYILSKTSNPAGRQLPPFSDLSPSSELGSYLPEIASDPRLEGSINAPPMTPRDVEIVFSNVAELAYFSETLLERLERALDFMSEENKIRWNDGQHGDITPDGAHYEDRPTEKENRETSQRARGPRSVHSIFRRRCCAMGEKRVHDQLRDWSRSFGKVVGVFGEQRANAFSDATIERGLLEHCYALQEAIVHKILLGPLCRLADLIDPPERCALEPLHYRWFERDVTIFRPPEQILSKSRLSLFLLMVSNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGV1</accession>
    <name>A0A2R6NGV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v12463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGV1"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="212"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR71610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="334" mass="37492" checksum="593B870079BC3A39" modified="2018-06-20" version="1">MDTQFQELDSLQRTLNHAIDTFRKELIAANLPALSSQATEPHPLDDNNYLAPTRLYEARRLAIASIVQLKNLLQYPFEKASEDAYAVYDRACVDVMISTGLADCLGKAPDRKKGLHVDDLQKELDMDGRKLTIVLRYLCTQGWVRETQEGVFALNRIGNELLEGSLGRGRLGSPYVPELAGTLVKWLQHPEWKYSDSVLHTPVQIVHKTDLSCFDWVKTRPDLFPYLSEAMRAAGNAYIRGLLTDYPWGSLEGQTIVDCGGGTGAMSIALAKTFPSLRFIIQDLPETLTLAKAQVGKLAPQAAAEGRIMTEFQDFFQPQCRKGDDYHYLFRHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGX7</accession>
    <name>A0A2R6NGX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001268">
        <property type="protein sequence ID" value="PSR71571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGX7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="10373" checksum="53F4C26D1C8256A3" modified="2018-06-20" version="1">MARRARHTQAARQASEEAREAARQEFLQQDKHMIWRQWYAELEELNRQAEERIRLQREHCLAQLPVVVDLTFTVLRSGRKVPKLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGY1</accession>
    <name>A0A2R6NGY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGY1"/>
    <dbReference type="STRING" id="98765.A0A2R6NGY1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="276" mass="30137" checksum="F2A8654FBDB30520" modified="2018-06-20" version="1">MSPDDYKALPVPPLPPTQCLNTTTFTQPKLDGSLSVPELYDWHLEHSPNHPLFVFSDEQGISTTIYWPEAARAVHRAGHLVRSLVQDDTSKTAQPSKPRVLAVLAATDSVTFFTLLVGVMRAGHTVFPISPRNSAQAVAHLLTKTNATHLFVGPEVAFQDLAAASLKVISSSGGSVPALAAMPSFEELYVKDSAKNFVPLPPVKPEWDSAAVIMHSSGSTAFPKPIVWTHYRYLLLSIVPYLGERDLTSQRLACHSLPMYHGMGIMQTGWTVRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH05</accession>
    <name>A0A2R6NH05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH05"/>
    <dbReference type="STRING" id="98765.A0A2R6NH05"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="195" mass="20527" checksum="9850D7732164780F" modified="2018-06-20" version="1">MLDGAYGGSSVDLGDYESVLLIAGGSGATFTLGLLDDIVGRCIKLGRRGGEKTRRIEFAWCIRSFGCIEWFSPMLMEIANTVAGTSLDLHVSIYVTCLCHPEAVPPIPNSEVGTYRPSVGKILKELVTPPSAIADDDSKELNCKLAWAGLGGGVAVCASGPEALLRETQNAVSKMGLTRGLELGGIGLHTELFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH90</accession>
    <name>A0A2R6NH90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001254">
        <property type="protein sequence ID" value="PSR71683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH90"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="12543" checksum="DF3A8074972135DD" modified="2018-06-20" version="1">MAEPIYKDKSPKTKDAQARPTVVEPLETPDTDLTGTAGEIPTKKSSSRVGKRTKKVNDAGTKQKVAPAVKKVAKTVIPANGQAGASIDKAVGTPRITEHTRSGRVRKPTAIVAAMTDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHP1</accession>
    <name>A0A2R6NHP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NIF system FeS cluster assembly NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHP1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHP1"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000013">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme ISCU, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="12672" checksum="802CFBF3ABCC92E7" modified="2018-06-20" version="1">MKLQIRVDENGIISDVKFKTFGCGSAIASSSYMTERVKGLSLEDAEKIKNTEIAKELCLPPVKLHCSMLAEDAIRSAIRDYRTKRSNLSNPKQSGFIDVAQSAATGETVATAHPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHT7</accession>
    <name>A0A2R6NHT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho termination factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHT7"/>
    <dbReference type="STRING" id="98765.A0A2R6NHT7"/>
    <dbReference type="OrthoDB" id="2368680at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="57649" checksum="D34C29806A88A69B" modified="2018-06-20" version="1">MSSQLPNALAKLTVPQLKALCKERKITGYSKLGKNALLLKLSDLQPPAEQRNNLNTPHDPPYGYVLHANGSTSKAEENALSVTKNAAADGVQVLSTLLLRDDTVQSGTVLEEITVPIGPQANTESTKSLHSSPTTGIVGGSPTQTEIRPSSSMAPPPRPLGKASSAARKRVAPSPLVSVSKKTKTNTPLSSIIPSPSNSTSANRVPLSRLSNPTQFVAPPVADMAEKSPENMHLTNRIQNTPKQQRAIPNTVSKPQTTTHLLSGKRFKPLVINKRVPSVTKGLSFCAQRDSEFVDALREKILASTEQPVTLYSLELPSVPAVPTLVPITLPPSLSQRKRVNRWAIILSALDNQNRKQCVLVSQDLYKLVAVSRFLVSRFWFALSLGGNGSEAWLRSVITDVKEIVAGEIWSVVVTSASSSGPRLDPYYVLDATCEVVGHPPEPVHPTCVSITTSQASNNLSQVPLRADWSTYIDTHIDGSLGSLLSHLKCANCEEYERGISQLWLRTVALEGEQGTAKRAVAERYVLACVVGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI70</accession>
    <name>A0A2R6NI70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001226">
        <property type="protein sequence ID" value="PSR72023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI70"/>
    <dbReference type="STRING" id="98765.A0A2R6NI70"/>
    <dbReference type="OrthoDB" id="2804491at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="283"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="664" mass="74781" checksum="79F9DD56686B55C5" modified="2018-06-20" version="1">MAGRQSDHAILKWGINTKVEPPEPSAQIKPDSIQMVQYLNDLHDGLREINNLYRDVNTQGTLKAMCEDSKTWWAKENTTAAKALKVVRTELADWQAELWEIKEILRKCDSRIPDPVLSQMGGREALTAGIPMCRDSIKALKRQEKTALYELRKSVRASKKKHFNKIIVETPHNMPRKQSAFSALRDAHGNIESTAEDRARIFKDAYHPPPKPTDPECLSDMNESPTRGAPGPDRITWGVIKNLFRIDGFPFHDKGELRPNTDEPEDLPPDQHTLAIITRMFNLCIKFGLWPEMFKRAITVVIPKPGKDDYTKAKSFRPIVLLNCLGKLCEKVLANRMQFDAQKFGLVHPCQYGGTMAHSTTDARINLAHQIRAGWQANLHTSMLLLDISQFYPSINHDIMIRTLIKQGFPKSLCTFFENYLKDRRTQFKLQSTGLSDPIDVSTGVGQGSALSPILSSLYLASSVQKFYSEHPRELGNNTSLFYVDDGNIIVSSDSPATNAALIGGLYQALEKELTRKGLSAEQTKFELMHFLVPKRGKQDPVKAWPLLRYPPDGAQGPPNQVMTILGPSVYIRALNGTITPVTPTEVLRYLGFFLDPKLNFNAHIERCAAKASSTVTALQMLGNSIRGLGPLYKRRLYIANVVPVMTYGMQLWWHPNLKNVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJP6</accession>
    <name>A0A2R6NJP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v11601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001159">
        <property type="protein sequence ID" value="PSR72531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJP6"/>
    <dbReference type="STRING" id="98765.A0A2R6NJP6"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08296">
        <property type="entry name" value="CAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR72531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="337" mass="36222" checksum="3BECBEAF6B71135B" modified="2018-06-20" version="1">MSHPQSYIAYRFEELGGQLKRAEIAWKDPEEGQVVAKVLACGVCASDEVVKYQGIPTGFPRIPGHEIVGEIVAVGPKEEIYKVGQRVGSGWHGGHCHKCSHCSSGDFIMCDKEDINGVFRDGGYAEYVTLRSEAITLVPEDMDPAEVAPLLCAGITTFNSLRNMDVRPPDVVAVQGIGGLGHLALQFSRAMGYRTVALSSSDAKRDLALKLGAQEYIDGSKVDQAKALQDLGGAKVIICTAPSPKVIQALLPALAVGGQLLILAISHESSEINLSSLINRRTSIRGWPSGTAVDSGETITFSKIHGVKCLVEKFPLDKAQEAYDHRAKARFRAVITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLB5</accession>
    <name>A0A2R6NLB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001100">
        <property type="protein sequence ID" value="PSR73177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLB5"/>
    <dbReference type="STRING" id="98765.A0A2R6NLB5"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35165" checksum="67B53759A4D82EB8" modified="2018-06-20" version="1">MNFSEFPFGPFFLALYLGSSGIRKGSLSPSGGLAAFIIGFTMMAIRLRTFGVALIVFYLVGSKATKVGKELKARLEEGHQEAGYRNAWQVLCNSFSAFLASLLWSALYVPNSVAASLLSGSSIMDSRRPYDFEQWCPATLRSTWSRTLLFVCLGHFACCLGDTLASELGILSTVPPRLITTFKPVPPGTNGGMSLYGTLASAAGGIIMGLTIALSLLLESGSCRREWQGVVFPLLGWGAFAGLFGSFVRIPPHNIGGSNPNIFNVQIDSLMGATIQRTRFSSKTKRILTDESPAPKDTEIKIISGLNILTNNQARSHRDPNLPVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLF3</accession>
    <name>A0A2R6NLF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v10932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLF3"/>
    <dbReference type="STRING" id="98765.A0A2R6NLF3"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="328" mass="36276" checksum="02E79E49841D646E" modified="2018-06-20" version="1">MRREKGDSSKARDYLPADKQYLMTRGVPCLRRATALAYTDEDEDAERLLSFGDLSSTGNEEDEWVETHTGRPANHESTTAVGDMDEIPDVDEHNEIVSDAMGNMSLSSGKASGPADMPDMDEIPDMEEEDLEGDDDAAVSAPKTVAPASRIIDASEIEVAKGNLLQVRTYDVMITYDKYYQTPRIWLIGYDENRTPLTPSQIFQDVSADHAFKTVTIEPFPHSSTLQAASVHPCKHASVMKKVIERMNAGVIEEQQAQRKAGAGSANPKDKQKKWLFRKTSGNGKTDQTVVAGDEEIEGMRVDFYLVVFLKFIASIVPTIEVDSTTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLS7</accession>
    <name>A0A2R6NLS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001088">
        <property type="protein sequence ID" value="PSR73283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLS7"/>
    <dbReference type="STRING" id="98765.A0A2R6NLS7"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10424" checksum="BB0075973F2948D9" modified="2018-06-20" version="1">MVPTQDDSKATTKFRVAICGGGIAGICLALSLSKYPDIQVDLYEAAARFTEIGAGLTVQGRTWKPLELMGVDATLRKAAAAANNVATSEFSIRDIFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM18</accession>
    <name>A0A2R6NM18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v10671</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM18"/>
    <dbReference type="STRING" id="98765.A0A2R6NM18"/>
    <dbReference type="OrthoDB" id="2802867at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR73379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36783" checksum="2E661718DE28BA7B" modified="2018-06-20" version="1">MPSNNAIDSPVNFSFLLILVPLFVTCISWFYSRSKRRHSLPLPPGPKPLPLIGNLFDIPQERPWVAYMDWSKTYASDIIFMTVFSQPTVVISSAKAAFDLMEKRSNIYSDKPRVVMDELTGWDWNMGVMPYGQRWRDTRRCFHQHFHQGVVGKYNPIQIREVQAFLRRALISPGDVEVKSISQTIAAIILGITYGIQVHDMNDDYIKLARKSVEGLVLARRPGVFWVDYFPLLKYIPAWVPGASGKQLGRFYKPLVEEMKNRPFNAVKNDVLTNMATPSVAEKVIVALQQKPTSNEVYNMMEQVARDALGIAYAGSSYRTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM24</accession>
    <name>A0A2R6NM24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v10737</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM24"/>
    <dbReference type="STRING" id="98765.A0A2R6NM24"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="407"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="526"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="603"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR73445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="887" mass="99592" checksum="9787DDBBF63081E2" modified="2018-06-20" version="1">MGVPALFRWLSKKYPKIILPVIEEEEIKVETEGEDISIPVNISGPNPNEIEFDNLYLDMNGIVHPCTHPEGKPAPESEEEMMVEIFKYTERVVNMIRPRKLLFMAIDGVAPRAKMNQQRSRRFRSSQEAKEKEDARQEAVAMWEAMGKVLSEDEKNKKSWDSNAITPGTPFMDLLSSSLKYWVAQKLNTDPGWKEMQVIISDASVPGEGEHKIMDFIRRQRSNPGHDPNTRHVMYGLDADLIMLSLATHEPHFRVLREDVFFQEGSRTACRICGQEGHYAAQCTGTKAEVKKTPPEKKPFIFLDVAILREYLEAELKVPQMPFPFNLEQAIDDWVLLIFFVGNDFLPHLPSLEIREGAIDTLLKIWRDELPRMGGYLTNHGQLELSRAQIILEGLAKREDEIFRRRREAEERQDHEAKRRKIQSKQSVDGGGPSPSPNLTGIPQAPLPISHALPARPNSTFAAKADSIGLGGPKTAETAQLAPTAAQALGGSNRDVVANRRAIRMANMSAAEVLKAELAGLVPVKPSASSLRSTSTPTMPPPQLPSNGSIPPALVPPSGDDDSEVPGLGNAGVNMAEPAIDLDADAEGEPDAASEDIAMLEAGAEGSPHGHKRKIQEVEEEDAAVEAEESVPIDEDDQDDAPADADTSVALALKVRSDGTVEQEDHVKLWEPGYRERYYRQKFDVDFNDVEFRKAVTLRYVEGMAWVLQYYYQGTPSWTWYYPYHFAPFAADFADVNAMDLKFDVGQPFKPFEQLMGVFPAARYVHRHWYYFARLLTSIWNSRVHIPSVFHGLMTEQSSPIIDFYPSTFEIDMNGKRMAWQGVALLPFIDEKRLLDAMAPGYAALTEEEIRRNQRGNSVIYAFEENPLYPALETLYGKRKSQEVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMA9</accession>
    <name>A0A2R6NMA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001070">
        <property type="protein sequence ID" value="PSR73528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMA9"/>
    <dbReference type="STRING" id="98765.A0A2R6NMA9"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015362153" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="523" mass="55625" checksum="4361CA057E0AEFB7" modified="2018-06-20" version="1">MLVLPGLLLLISCQVIAGDIPEKTRGNHLPLIRREVKRAGGHAHLGRRGGGTAEIGVGDYLDLANQQVELLYGDSRTGTRAVGPIGNDTAGIAGLVIQDQYLAAIVETNTTVLETGSAGILGFGFPAISVLWRQLLQAQLNNDPPSKRAEGRNLVARIFPDFNFRRPTFPSFEFLLPPSHAHTKRQNATLLSSAEVIASFATYGPLFTRLISQNMVESPMFAITLQRDTVDIGGNVGSLSIGELPNGIQTDSLTWVPLRAYTPQEGGLPPAPEAPNEVYPLVWEIPIDDVYFDDVKLPRSSLSPPSISLSALIDTGNSLIRGPQDVIAQIHSSLGGEDFDCGMPHNLTFQIGGKLFSVDPRDFIHQSFTDSVQQCNTALAVTDPPGDGFLYSWSLGDPFLKSALAAFHYGNLTHPSQDPPRIGLLSTIPTDAAERLRQAVSAATEEGSGNFPATSQPAPSGTFVATGAGVGGVPQATHVPPDLNGSEPSSTNGAVYTAWSGAAWSPIWGTFGISILSFFCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMM0</accession>
    <name>A0A2R6NMM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMM0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="12478" checksum="88744BEE0577832C" modified="2018-06-20" version="1">MESVSASDDIGMEAFRTIENAATLPKKFERETASGVRRVTSLMGITGYGAQYDSTITNSAQSTALLTRRPQITGCDQGISSVDFRLMPNRRQPTVPTKVKEPKPSMRLSLVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMS1</accession>
    <name>A0A2R6NMS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMS1"/>
    <dbReference type="STRING" id="98765.A0A2R6NMS1"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="481"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="796"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="942" mass="100852" checksum="2467EA4215DC906B" modified="2018-06-20" version="1">MSGSPSLNPASTPFFPGGGGLIKEDDGRNPGVGLHRHIGREQYNTSTSSLSISPTEYRSVKSSPSPQHESDGLDRRPHVRQYQSQVEVSHQSPYVNQIEAERGFPIMQRVSVKESSMSAIVEGPPDSEGISGPTTATNGSYQHMSFYASMAPRVRDRLNTPPVAMDITSRTPSFNSGPTHFMSSSPSSSLDSGSLFTPSVDLPTNFEAQLKASPLINEMLDRLARYEYASREIHRDLTDVRGKFDLLVERTINANANTNANIAPPEFRDPFASATPSFSMPGFNNVNGPRSSIIGNIAPNQAAPPDDISVISHRLNSLSTSVDQLLALSTHQAQVGGSLQPTSVLSQSPQPNDLLGRTMAPPNTVNLGHGLPSRADIRTTPRIPGPPMRTWSAGTLDLPMRSSDSPTGSIGRADSGLRDKRRSVTGLLRRDSAVADAFATSSRESGPVISKWEQLTLAPDLLRSLNQFGVGPPNKIQQRALPFLLRGSDIIAQAPPTQERIAAYVIPAIHIALVNATNHGVSLRGPLVVMISTTVDQATQAQRMIRDLGGPIGVRSALGVGATSAGTDLSQELRLLHQNMPHIICGTPQKLHALFTSSGGISGSEVRFLVLDEVDQLIARNLHDFVFNIVKLLPPPRSRSVGTNTPTQNPGGASPSLYSLFDGNASSSSLNAVNAGRRFSTAPSSSPEVASANPPVVERQTALFSNTVPQDVLNLASAIQLREPVRVLVRRDGNVTQADTSQGARGLRQFYLYLAFTAGGGRTDSFSQPGNLGIIGSGRGASSAETAQAREWKLDALTDLFDDVDVSQAIIHVGGLTALESVAYKLSSRGLEAVPLHGDMNASTKLAALNKFRSPTPGMMRQSSTRVLVVYDVVVKTPEVPWVPLVINYDLPKAVEEYAHRVAPAIAPNYSRAGVVINFVTATGGDVEMLRSIECFYNPKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN13</accession>
    <name>A0A2R6NN13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v10416</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN13"/>
    <dbReference type="STRING" id="98765.A0A2R6NN13"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="49"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR73772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="468" mass="51995" checksum="6F963AFEE66A0AF0" modified="2018-06-20" version="1" fragment="single">QKMSDKGSFIGDRPKSIDVDGSSISDSDIEKQFVIRVAQESQNEVKFRTCSWQKTAALLFSEYICLAILSFPWSFSVLGMVPGVIVTLAVAASVQYTSLILWRFCLKHPDVRDVCDIGRILFGGSQLAYNITAVFFILNNTFIQALHCLVGAKLLNTLTNGSAACTVVWSVVIACICFFISLPRTLSQLSGLGVFSAATMGIAVLLAMIFAGIQDHPFGYIVGQEPLVTAFPVKGTTYVAGMSAFLNITYTFVGQITLPSFIAEMKNPKDFPKALWAVTIAEVVVFTLCGAIMYHFVGNQYMTAPAFGSLQPVYKKIAFSFALPTIIFLGSLYSSVSARFVFFRIFRDSKHRHSNTLVAWTTWAGIVAATWVFAFIIAEVIPFFSDMLSLMSSLFDGWFGFIFWGMAYLTLYPGVKKWAGFWRSSETVLNYVIIVFGFYILIAGTYVSWWLYYSRPKKINIGALFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNA5</accession>
    <name>A0A2R6NNA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001070">
        <property type="protein sequence ID" value="PSR73533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNA5"/>
    <dbReference type="STRING" id="98765.A0A2R6NNA5"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015325516" evidence="1">
        <location>
            <begin position="30"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="240" mass="25332" checksum="7B1D30E93084A005" modified="2018-06-20" version="1">MAFIGSSTRVSALTLLYAIGSLFVGSSSALPNNTVTINPLSYNVYGSNAVFRNNTFANLFNPTNTTAPFFQVFDPSFLTVLGDSPSFRVIASNPGFAFAHEAPIWVPSTQELFFASAAGSPSGFSDINHNNQVAKISLNDVTTAIAQSSNATAPVNVTVTTLDLPDTVQMTNAGTGPYNGSLLLVNSGRGPLPPNLVLVDPANPQNATVILDNFFGRQFNSLHNAKIHPTSGNIFFTDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP61</accession>
    <name>A0A2R6NP61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoin permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP61"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR74235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38884" checksum="2EBFDF732FA46CCD" modified="2018-06-20" version="1">MGRRSVQQYLKPSTWALEPAPSTFAPNSRWSNKDMDPVPPKLRTWNTYNYIAYWISDATNAAVWELASSMLAIGLSWRQALPAIAVGHIIIAVVMVMNGTIGARLHVAFPVLNRSSFGFWFSYFSVISRVVLSMFWFGIQTYTGSECVYQFPFMLISPQRIRWLFLLKALIVPPVWLAMLIWAVVKVPTSKGLFGQHANIAGASMSWAWLSALNSALGIYSTLAVNIPDFTRYAKNERAQYVQIIIIPVAFTLAAFVGMMVTSAGTVLYGKVLWDPLTLINEWDNRAAAFFAAATFMLTTLGTNISANSLSAANDMTVLFPQYINIRRGQIICAILGGWALCPWEILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPJ7</accession>
    <name>A0A2R6NPJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001032">
        <property type="protein sequence ID" value="PSR74034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPJ7"/>
    <dbReference type="STRING" id="98765.A0A2R6NPJ7"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="217" mass="24607" checksum="5CA1A1E5474C351C" modified="2018-06-20" version="1">MLRMGRKYEVPRLFEEAVRRLKFCFPTTLRGLDAFRAAKILPIQNVWDGDVLFKIINTIQGSEFEPELDYLLPSAFFACTLLDNKTLLKAARDDAMTINFLDAVFGGRQRLTSAFLREDQLFAGEDLPRCVQWGLNCQTTPALHQTIKGVFVKVLTANDPFIELERFLRDEGARNGGICTLCVADIVARYNRGRAEVWKTLPSLFGLEIAEGWPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPU5</accession>
    <name>A0A2R6NPU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPU5"/>
    <dbReference type="OrthoDB" id="5553410at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028110">
        <property type="entry name" value="TMEM254"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37783:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04315)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14934">
        <property type="entry name" value="TMEM254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2470" evidence="2">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="225" mass="24943" checksum="7047B3005929738C" modified="2018-06-20" version="1">MSDPVAAKSTFLCMYMSNHPDTLVSYVRHYAHIPHTVSSAQLSSISSTGMTLTYATTAQEKNTVVVPFDPPLKGYDEVKGRMMQMKAEAEEALGMMKAPHITSFTVPPGLWRTALMMLALIYTTFSPSSSSSSPFDLPWVAALVYPATWIRTTLPSGSLAWIWGFMIFVHALESLYTLSLCRKHHTGVVVGAMYVLATFAFGFPVFVDFRKRVQAIRIDSIMKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ80</accession>
    <name>A0A2R6NQ80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000962">
        <property type="protein sequence ID" value="PSR74704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ80"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="177" mass="18695" checksum="AB1DEE5F2A17B77B" modified="2018-06-20" version="1">MTDSSLKHKYIATSTASPDGSKFSKLFGGEGRWGHGLSRGKTAAPISTPSEDTLSYEHDVEQSGPMIWRVSLDVEDSGQTDSEKPEENMSTRASYGGPHPDPPDPPPVPSLSPSVFGRSAAMTSEVSVSGPPISGRRPWQEEDGGVHIAGERSGADAQSVGDTGSLHTLPPAYDDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQV8</accession>
    <name>A0A2R6NQV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR75000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQV8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="12413" checksum="62BC1255722A4341" modified="2018-06-20" version="1">MPSDQMMYVGGVPKGDAMKEKGKRELSPCMRNQGSSSQVSFGRREEIIEAGVSVSMSGFVKIPPPKLLALKAVDISVPAAVFGPQWHQGKIFEDEAQKLYWKSCDAAHPARMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQX3</accession>
    <name>A0A2R6NQX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v9388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQX3"/>
    <dbReference type="STRING" id="98765.A0A2R6NQX3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR74974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47839" checksum="33443128C1AD2934" modified="2018-06-20" version="1">MTRPFFSRDRISHFELFDRHAGQAIRKLRDRLGEGHAVDFQDLISRFTLDSATEFLFGSCVHSLRNSLPYPHNVPMPGAHQSPAEDFAKAFAEAQTAIAHRARVGWIWPWSELFHDKTELPMRVVDAYLDPILKAALKKAEDEKESGRVNEEVRDDLEENETLLDHLVRYTTDPVVLHDEVLNIMIAGRDTTAGMLTMAVYFLSQYSVVLRRLREEILETVGPTRRPTYDDIRNMKYLRAVLNETMRLYPAVPWNIRSAVKDTTLPSTDPSKPFYIPAGTPVTYSVQCMHRRKDYWGPDAEEFDPDRFIDARLHKYLTPNPFIFLPFNAGPRICLGQQFAYNEMSFFLIRLLQTFETVSLDVEAQPADSRPPTEWANWPGRKGVEKFWPKVHLTLYSKGGLWIKMDETKNSDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS06</accession>
    <name>A0A2R6NS06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS06"/>
    <dbReference type="OrthoDB" id="2790277at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="127" mass="14194" checksum="EBA5E15E74FAFF69" modified="2018-06-20" version="1">MSILLTHLPTFPESKRSQYGPLCSHPNASCAFATFPPMQSLSFQDPWGRVYITVENPDGITILDVNRAFAQLIPEDPMPVEAALAHYRDLLLTSGKSPTQFAESISRDRGFLDDHEYPFLQELVAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS69</accession>
    <name>A0A2R6NS69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polysaccharide biosynthesis domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS69"/>
    <dbReference type="STRING" id="98765.A0A2R6NS69"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="2">
        <location>
            <begin position="7"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="18969" checksum="38AC09175F394BC2" modified="2018-06-20" version="1">MSAPFDANNAQNLVETYWNLLEKVDPKDLRLSKLDDDIFDHFKREFPENFEEPYEHITKLDEESMKSKEGKEKWRKFIESYKDTVKDYNFGSLIRTDARDEYSEKNTIFTTRIQFYAFEIARNRLGLNAKAHEIAKKEAEKEKAKAEKAKEKGKSKSNGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSC2</accession>
    <name>A0A2R6NSC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSC2"/>
    <dbReference type="STRING" id="98765.A0A2R6NSC2"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="4">
        <location>
            <begin position="306"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="5">
        <location>
            <begin position="587"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR75783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="942" mass="103551" checksum="1DC83BAD5E0E5602" modified="2018-06-20" version="1">MATEDGVDQETGEVEAVTRTVVVVVVALTAVVVVAALTVAAVVSIVDEAETEGVLEAGAALENKADLPTRPDFGTVGQEIKLRTNFFPVKVPKGPLYEYDVNITPAVSVKRVKRRIFQLAEQAVDWANAGMSARVAHDHASKLIAADKLPQPLVITVPFTDEDEGEELPQSKSKGGKKGDKKADKKVDKKKEYTLTITFVQDLETQSLLNYLAGHPQYRGYDIMPVISALNLILAAHPNRSMGGGVMVGRNKFFHPSATEPPFPLGGGLEAWRGFYSSVRPAHKQLMVNVNVCTTAFYTPGNLAERMQEFMNASFGARPNTFARGVRVKTTHLGYQKSVKAVSHYTAKTYSFEVEGLGKRTVEEYFKERYNITLRYPGLPLVDVGGQKKNYLPMEICVILEKQPFKGKLLDEHTAEMIKVACRPPNVNAGAIVNRGLDELGFVQTASPLGAFGVSIGREMAVVPGRILPSPNIRYAAGAPRVDERASWNLRDVKFSIGGKLNNWAVLVIKEANSNRDEFEGPNDPELLRTIKGFADMCRKSGMSVSPQQPVCAMARLPPKQKEDPIRKQAVKAIQDALRTIKPKPTFILVVLSNKDRHVYSGIKHLCDVFLDVPTCCVQSSNIRKEKGQLQYFANVALKLNMKMGGVNHTMEGANTRWLKQEPTMLVGMDVTHPGFGTVKGTPSIAAVVGSIDEYFGQFPASLRIQESKKEMVSALADMMVERLKAFQAKSKKLPQRIIVYRDGVSEGQFAHVVVYEMPEIRDAFKKFTTAKGPYSPKLTIVVCGKRHHTRFFPTEAQQAAGDGNPRPGTVVDRGVTAVYEFDFFLQAHGGLQGTTRPTHYYVVHDEIGFKADQLQTLTNEVSYMFARATKAVSLVSPAYYADLACERGRCYLHSLLQGISSSGTTATSGAGDAEEEAVMREAQSMWRNGVGAGLRETMFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NST5</accession>
    <name>A0A2R6NST5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NST5"/>
    <dbReference type="STRING" id="98765.A0A2R6NST5"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="298" mass="32996" checksum="F7327F5B91152E78" modified="2018-06-20" version="1">MGRLAEMQRKLLEQMMGPEAMGVANANLVWSDEKVCRNFLCGTCPHTLFTNTKMDLGACPKSHTERLKTEFLQARETDSNNPIFSRFQMEYESNIFAFVDECDRRIRAAHRRLEKTPEENAKTTNLMREIAEIELAIQGGTEKIETLGEQGKVDESMREMAAIEALKSEKAEKERELQQLTDTSGASGHQKLRVCDVCGAYLSVLDSDRRLADHFGGKMHLGYHELRNMLGKFKEEREKRKMAPPSSAPSAAPAGTGSGSATPSGTVNAEENALVPPGVGDTETLELLYDDSGRPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT66</accession>
    <name>A0A2R6NT66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT66"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="77" mass="8973" checksum="9AF36E1197B1EAEA" modified="2018-06-20" version="1">MEIQRDAQVQSGSTNPQLRIWFMSCLQSTPRFGIAFLTPQELSKSKNKSIVKVNFEFHSFSWVKIWILQNEPMSDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTE9</accession>
    <name>A0A2R6NTE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTE9"/>
    <dbReference type="STRING" id="98765.A0A2R6NTE9"/>
    <dbReference type="OrthoDB" id="18703at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR75923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="153" mass="17257" checksum="3AED495B131E9392" modified="2018-06-20" version="1">MKKKEKQMVKHELFLQTTTGLESSRSPYSKSHERRLRRKAKEEVAGGLGNIKAAISAVEEDIPTAVQKTIQQTVSQDDDDMINDRTSAKKSTLGQIGEGKHVPLTKSQRKRTLQTERLRIPMILSNAEFHSNPFQTIRTHAQNTLLTHNKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU06</accession>
    <name>A0A2R6NU06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU06"/>
    <dbReference type="STRING" id="98765.A0A2R6NU06"/>
    <dbReference type="OrthoDB" id="3355480at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="63643" checksum="7E87D327E4A17504" modified="2018-06-20" version="1">MGFSQEIRLPLTPPLSDSDDELPGDSCSVAPDFKPSITEVRTHYERKMGDTELSYYLPSRQTGVNDMYLHLGFNAPDHLIGRSRVRLVWAMLRLRHPLLGSSVQMNDYDDVRFVYPVPTSSEGLIREADHNLEYRAQSKDVLIDSYLNGPRTLSNSRLSYLILSQPNPEETLLTPPPTPSPNQEGRLKLLLEEAVPSMRQHELLICAVHFMGDGMALHQFANELLGLLGSDKSEDELKIMLDEEWKSRWGNESNDASILPSALEDNIPLRWSKLRTVAAAIDFEMSQQKLIGGQSFPRRKDPERHTIVPTLSFPEDRTKAILKKCKANGVSISAALFAICNLAWARMGGGSKELPVLMYSALNLRPSFTIKRPSPWDSYWFLAIGYFNVILPNFIPSDERAVEATFWHRARQAKEQSGKAAKNPLLVSRTHEMAKERGERARRWAKEDDERENGTWVPPTAVSSVDGPQVRKDVIIPARKAVPSAALLGLSLLGNLDGIYKHAAFPSIKMHTLTTGSRQRHGAMLLFGYTFAGKLWVSLGYDENGFKEGVVDRFWSEAISGIEEFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU09</accession>
    <name>A0A2R6NU09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v8260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU09"/>
    <dbReference type="STRING" id="98765.A0A2R6NU09"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="444"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="922"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="934"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR76663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="996" mass="108498" checksum="16658A8B5D43B7EB" modified="2018-06-20" version="1">MPVAVERIPAMGVSKGKSIAEPHLQPLPPVDTPQKTSRRQKHHREAGDSVQIQPVAGSSTTVNDPDWTWRSLTESSASRVPPILTKDGSYFLSATGPSIKIYSVSTCHVVSTLSIAGTASRPSNPTGYGEAITSMSLNPHNPFQLFTGSLDGCVRVWDFVDAILLQTIDVCYPILYLAAHANFKNEVCVAVSKKTRKLNHNRNPTAEENASVLRVSLTPTEATSKLPVQRTSDLLVVGRTRAPFGLAFSPSGSWLVVIGGHKSYVARTSNLKAGFTKFVSPDKLSCLAFHPTEEYFATGDSKGVVRLWYCLNDNIPSGVIGVEKKAPTTTLHWHAHAVSSIAFTANGAYLLSGGEEAVLVLWQLHSGKKEFVPRVGAAITNITVSNAQGRNEEYLVGLADASFIFVRSGTLKISKTIARVKLDPAISHDRPTSSVIPLAAHSITSSLILPSSHPSTLQTYSVLNSTLLSELEVSPSNRVSRREDKAAEPSRVTIARISENGQWMATVDSRESRDEFRGEVYLKIWWWDKKTSSWILNTRVDRPHGLKKVTAVSFRPRAKDSSLLRLATTGEDGNIKIWGIQSTTSKSGEGEAFWVTRSTIRFRSEIPSHVSWSLDGSLLAVTLGPHVVLYDPTTSIVLKTLTCPECPAPISTHFIGRSGRYLAVQGLQDIVLWDIITDNVRWHYQSATKINHVSSHHREDTFVVFEADSQTFRTRVSKFSPSSAVSLSTHCLPFQLLSIAACPPRWLQSSDPSSFAFVGVTNTWNTVVFGDQIHLVEKDEAQARGIGGAAPVTKQTLFQDLFGKSALNDITTWAPLPPSVHNQGSSWKGKEIEKIFDTAAYLLPPLGTLFDPLMDTFLTLRTSNESEGKEDENLEQADEDMDMNAEGSEVPIVVGNRLERIVDQHEMLAMIELFQVHGLQSPSLTSPSTIPPTNGYSKTSGKPNGASSHTATMAKANGATPRPQKVKVSADGPLTPSQPTNSPAVKAGQKRKKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU22</accession>
    <name>A0A2R6NU22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU22"/>
    <dbReference type="STRING" id="98765.A0A2R6NU22"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="389"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR76681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="667" mass="75606" checksum="4F1C52EA6CD604A8" modified="2018-06-20" version="1">MPRRKPASGKQRKAQLQQKRAIIRGDIDPLPAKQDTHRKGKRAQVGQSTRNPAVAESVRRLQSSFVKLPSEFLEETKRLAANLPLHRPISSEVARWNESVSSQDPDDTDKREIEQLTCPKRPKWRYEMTKTEVEKNEEGLFKKWLDRSDEIVAEWCEPEIREPADDDEADLNEQILEQMPKAPTSFERNLEVWRQLWRVTEISQILLILLDSRCPLLHYPPSLASYLSAPHFARKRTILVLTKVDISGPARADAWAHYLTTKYPGLRVVQVESYVEKHVGEGSGARRMYEPYLPSAFRQTLVDALKEAHTELLEPPERIRDAPDKLAAWKPPVRREIDWGALLDARWSSVVKANPNRDIPSTEHHQPVDEQLDQLSEDYEDEADPDFLTVGLIGQPNVGKSSLLNALFGTQKVRASKTPGKTKHFQTLFWSSEVRLVDCPGLVMPSLAPMETQVLSGILPISRVSAVPLCVYHASLLLPLERLFALVHPSTAIAQADDKRTWREPRVREINKEKALVWTAMDILTAFALKKGWLTAKAGRPDISRAGNMILRMLAEGKIRWAFWPPDTPLSQLQSQQDSDTGIWIPHSVDEDNYFALVNDSSEDERIVKPSDSDESDDGDSEIPDSSEETTFVAPTGSRFGSLMFANEESDEEDEEESDPDNIPHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU45</accession>
    <name>A0A2R6NU45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU45"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="313" mass="35328" checksum="DB00E8219CC9A919" modified="2018-06-20" version="1">MLMRRVQQDSLRLEAALAGDRKAFGHVLDVAYGRKGKLKWEILQPLLSDPQAPVPDRIIPEVERSRPPVYSPELKALLSSSASRIGKALTPLAISQSNLPPRADPQSEEASLLGPFSKRREVNIRWRYFRTEWKKVFFPLEVSVEERHGSDPSVEKTDRDSVFRAGIRDVGLQGAGVLAEIQTFASPASKALQSIPKRPNRRRPMDAADARSSLPRSRLAPRFVQRRYRELLYRLPILKYSYDKLAEGSSRKPGRYSVSMDPNAIGASLPSVRIPDADDDHRAWFDHSDGSTKKSREAAKPSRIMGEYNERCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUR2</accession>
    <name>A0A2R6NUR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUR2"/>
    <dbReference type="OrthoDB" id="10051892at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="456" mass="50675" checksum="AAC2DFB9E9672EDB" modified="2018-06-20" version="1" fragment="single">SIIDFIILTTMDLALLRDPSPFWLLGVSFVSWILYKLAGKLVHAYLVKRLLTVDGLPLLGVQRGKKIKGTAVICGGRLVTHLMLGYQFVRIAFSISGLLSARVCADHFTDVLIIDPELAQVERTKASTRIAQYDSLHGYLTFVLDGMRRLWPNFDNELQKVGGHIAPGDVKPYFSGILIPAPYTEYEAKSQPLPETMFIRRPQLENLLRRLVLGFRSNVRTLVGTVRGLEAKQGPTARISAVIVRTGNGEISINDPTMVVDCSGDSQAGFKWLKKCGYEMPADVRLEYDQKLYYVTITFSVSEDMKKSMPIPGGYEQAGWLYTFVPQPKLTSAGFVLGKMDNDTMQLCCGGWGDVNLPLEADDIESYVKSMNGKEPVPDWLFETLRILVENGSPKFKPLKIRTSALPIFGSLICPTDASFIKQGPCSNIQYHKVRNLPANFVAVGDSVLQLNPIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV80</accession>
    <name>A0A2R6NV80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000820">
        <property type="protein sequence ID" value="PSR76986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV80"/>
    <dbReference type="OrthoDB" id="2801388at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="189" mass="21018" checksum="2826ED6AA5D09A71" modified="2018-06-20" version="1" fragment="single">MRGICTPSKIQVSKKSKFFQEASVEEVEDEDAPQQAQDSTDVFEQIRAPPIEDSWEDGQPLPKGVYRVPDPVEAYFKEMRAQNRVPRELVVAKESHALRAITALVDNREEIEAIIDPGSQIISMSEAVCHALGLSYDPSIILNMQSANGVVDPSLGLARNVPFQVGELTFYLQVHVIRQAAYDILLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVC3</accession>
    <name>A0A2R6NVC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVC3"/>
    <dbReference type="STRING" id="98765.A0A2R6NVC3"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="82"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="484" mass="56446" checksum="EE2AF1E6860D1AFA" modified="2018-06-20" version="1">MAYLKVSGTKIVDQNDKEIILRGAGLGGWMKWAHVESLFEITVDTLAGYPGCEFQIRAALADVVGSEKSEFFFDKFLEYFFTDADAAFFKSLGLNCIRIPFNYRHFEDDMNPKVLKPEGFKHLDRVIDLCAKHGIYTILDLHTAPGGQNTDWHSDAGTHIANFWLHKDFQDRTIWLWEELAKHYKDNTWIAGYNPLNEPTDPYQTRLIAFYHRIYKAIRDIDPYHALFLDGNTFASDFSHFGDAHKGWENTAYSIHDYSVFGFPASPEKYVSSEVQLKRLKRSYLKKREWMDQRGLCVWNGEWGPVYARKEYEGELTDAINDERFKVLKDQLNIYNEDRLSWSIWLYKDIGFQGMVHVSRETTYMTLFKDFLAKKHRLAIDAWGADDSQIRHVYQPLIDLIKQEVSPEHQNLYPAPVWKLQDRVGRLSRNILVSEFLVKEWAEHFRGKSTEEIDEIAKSFSFDKCLHRDGLNKILTENASSVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVG1</accession>
    <name>A0A2R6NVG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-5-taurinomethyluridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v7766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-taurinomethyluridine(34) in tRNA + S-sulfanyl-L-cysteinyl-[protein] + AH2 + ATP = 5-taurinomethyl-2-thiouridine(34) in tRNA + L-cysteinyl-[protein] + A + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11732"/>
            <dbReference type="Rhea" id="RHEA-COMP:11733"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:87171"/>
            <dbReference type="ChEBI" id="CHEBI:87172"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVG1"/>
    <dbReference type="STRING" id="98765.A0A2R6NVG1"/>
    <dbReference type="OrthoDB" id="3685at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="MnmA_TRMU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.280:FF:000001">
        <property type="entry name" value="tRNA-specific 2-thiouridylase MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="MnmA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046885">
        <property type="entry name" value="MnmA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046884">
        <property type="entry name" value="MnmA-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="MnmA-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001138">
        <property type="entry name" value="PRK00143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF5">
        <property type="entry name" value="MITOCHONDRIAL TRNA-SPECIFIC 2-THIOURIDYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03054">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20258">
        <property type="entry name" value="tRNA_Me_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20259">
        <property type="entry name" value="tRNA_Me_trans_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like central" evidence="13">
        <location>
            <begin position="208"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-specific 2-thiouridylase MnmA-like C-terminal" evidence="12">
        <location>
            <begin position="278"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR77576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="364" mass="41055" checksum="6E607C2FC746851D" modified="2018-06-20" version="1">MSGGVDSSVVAKLLTQADYDLSAVYMRNWDTRDESGSDSGCEWKKDYADVQRVCKALDIPCTMIDLSKEYWNTVFQPSLHEWEAGGTPNPDIWCNKEIKFGALMKHLSTEDTWVATGHYAHKSWSSPLSFSSNILPRPKLLRPVDRHKDQTYYLSAIPESSLSRTLFPLASFTKQQVREKAHEWNLPTAAREESMGICFVGEKRRFHEFISQYIPPKPGNIIASGKVVGVHQGLWQYTIGQNTRIRGMSQKMFVSHKDLLNNEIHVVAGGEHRALYRKGIVAKDWKWIWTDAAPAGIDAPEGFHALMQFRHRMLDVGCIVRRGKSEDTVVIEFEEPQKGVAPGQVAALWDGTWCLGCGVIESTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWY9</accession>
    <name>A0A2R6NWY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000726">
        <property type="protein sequence ID" value="PSR78755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWY9"/>
    <dbReference type="STRING" id="98765.A0A2R6NWY9"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="210" mass="23158" checksum="C708CC002ABC0BC9" modified="2018-06-20" version="1">MRIDWNPITREEGLNPSADGFTVYAAEKTLAEHAVWEFGEKHPHVDITTVNPPFFYGPFAPGWAASEPGVSALSTNGLIYNLLRPDGPSLLHPAVIDVRDVARGLVLSLTAPPTSQVGQKRILMSGPWLSAQEATDYIAEVRPELKDQLSEAAKKSGPIPKHNIDTSRARDVLGLEFRPWKQTLIDAVDSIIAVEKEWKSQGWKGEGWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX19</accession>
    <name>A0A2R6NX19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000732">
        <property type="protein sequence ID" value="PSR78659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX19"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="831"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="955"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1012" mass="109461" checksum="F49F955494A99850" modified="2018-06-20" version="1">MPRTLSSESPPSSVSFASPTSPTSSVSSSSSVSSVSSFAHTPRSQLRDLNDSLVFAGIYQCNWNRCVNIYRTYDDLVDHLRSQHLNADEIERVCKIPKRHWETWKRMEKQAMQSGNDFMAEIKKNITGESSGTVHKHSQTQTEPEPQTMQTEPPSLPSLPLPTHVPRGPSSPHEHSVGREPALSRSLSHSAHPPERTEPVHDTTDTEPPPPAPLELTLAYLPIPVLPSLSFPLPASPNSDAHLSDINSRIPSVGNLHPGTLPLPRRSQHHRLASASCSRSPASLVRQRSSATSPPATPSATPPITTLLSPLPVTLISALPVDRTPPHSRKSFREFTSLSSPAESPSLPSLGPSPALSALVRRAPLVNGDGSRALDGTPLGFAKPEPESEPELQSSQERSQSAEESGSTEEVDGVKDETYVVVRTVLVTYEPKEEETDEDEFLYEHDELAAARQWAEGVLEAQGSDSGSDVQREEVEGDRIGGQQETDDEMEVDQEPALVDDPADSSGDEDEDESDKEDPDDQVPLPSGSRLPLQSRPDSASSSTSAFDVELQLTQDVGSPAVDEKADVMGLDSGIDVRDQGPVFAWPSPPPHFAPVLSPPPQARMETPEPPLRRSTRRATSRTPSVAPSATAIHDALFLRTGRVLRCYPKTMAVALDPMSRDEQTVKPLPLLPRRTRRGSSSQSLAAIPGANTAALSTPVVPNDDDLTTNGKRKRTRSVSRAPTETGDVRLKRFRSGRLDVSLSLPDTTMPAPNAPVSTSDKLGVDTIPEVDESATIEYEGATNGASALESHNALARQVPEPELAPTSQLLLHQETFRPMFRSGRLDLSKSLSLSQSPSRGAGPSRGPALPATSPARYSLRQRTSGTSTERYSLHQRIESMTTPPASSRSHSTHESPGSRLLVGFPRLARQEKASPPSQTPLQTQYEQSQANRSLSQGQREIVGSPLPRRETSIHSRTSSHSFMRPSQSPNATARSDWERQTLGEGGGGGFSQVPLMTQAPYSSPSFGFDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXB8</accession>
    <name>A0A2R6NXB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXB8"/>
    <dbReference type="OrthoDB" id="3260716at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="221" mass="23620" checksum="72C4228269E4D585" modified="2018-06-20" version="1">MSDPTSITDTRHNDYVGNDANIGRIPGAEKATTGHHYVSVFPKGEPQPQPRSISTSQMLSPEGPPPKHGNDGALRPEEHLPAPTGRDRPPRGINEAIHTSSSDHQGHISDRISNARNREPAPQFHHAVPKPLSPAPGSRTVIDRDPMASPATAGETLGGATSQDVYDTYGAPGGGQTSTELHHDGNSKRKRNLQGTDQYGTAEDVAKRDNDVDLSGWKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYC9</accession>
    <name>A0A2R6NYC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000674">
        <property type="protein sequence ID" value="PSR80027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYC9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="137" mass="14456" checksum="0479DB732EEA0A6E" modified="2018-06-20" version="1" fragment="single">YPGSLGSLETLLALSPLLGSQDSTLRSLNSKGRGKAPILGQETAGSSKLKVFCAKVKGGLNSKILGPRYVKSGWNFSSRLLRTLQGVSKRSEMIASAAGYSKLEGSNIGFKFEHGLESKLLGLGDVESCSTLLVYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYK9</accession>
    <name>A0A2R6NYK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v6749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYK9"/>
    <dbReference type="STRING" id="98765.A0A2R6NYK9"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056236">
        <property type="entry name" value="HMA_PCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24534">
        <property type="entry name" value="HMA_PCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="195"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR80364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1010" mass="106577" checksum="99D11DF14E2F581F" modified="2018-06-20" version="1">MPSETLYSPATNSDDNAQVHSCGLRQRKTTKTTKALPKEPCGEHMSLARSRQKDTLTAFGCVCRALLARGVQQCCPGRSPIAHSISSSLSRLRNSKSRVSVDSCGGESCCGGIARKENRSTHSSTGGASRSCLSVNTAGGKCEYGGLDGIQSIPRGDRKSADSCAASCCEGSTHTVELNQEKHAVIDIELSGATNHAILAVKGMTCTGCENKLIRVLKAQSLLTNVKTSLVLSRAEFDYIGEPEDLQALIQTIQKRTGFATERIESAGTAHALELIISPSLQEKFLHTQYPDGVQQVVKVRKNAARVIHDPQVIGARDVLLYYTDFSPILAPEPQDPALTAGAKHIRMLLARTIVSSILTIPVLVMAWAPLPSHPNAYAIASLVLASFVQIAIAGPFYGSAFKSLFFSGLVETDLLIVLSTATAYIYSVVAFAYAIIGRPLEGGSFFETSTLLVTLIMFGQLASALARQRAVAAISLRSLQQPQATLVYTHPDGRVTEELVDARLIQYGDTFRVLPDSVVITDGVILSGTSSIDESMMTGESLPVEKGVDSEVLAGSVNGPGNLLVKVTRLPGENTISEIAGMVDDARFSRARVQSIVDRVCAWFVPVVLAIALITFMIWILIGVRVRKENTGQAAVRALTYAIAVLAISCPCAIGLAVPMVVLMASGVAARLGLVFKAATTIESAREITHVVFDKTGTLTMGHLEVVKAEIVDGGETPEDEKRSVILALASASKHPVSRAVTIYLISAGVTPSSKVDNLGEVTGKGVEGSMGGRSIRGGSARWLGIEAHPSVQHLLAEGLTTFCIMDGNILIAVYALSDTIRPEAASLLVSLRARNIGISVLSGDHAAAVDRVSSSLGIPSDCVRAGCLPADKAVYIRELQATGAKVMFCGDGTNDSVALAQADIGVHMSSDASSSGAGAAASEASDAVLLRPSLTGLMSLMELSEAVHKRIIANFLWAAIYNLVAILFAGGAFVNARIAPAYAGLGEIVSVLPVILVAMQLKWFKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYZ0</accession>
    <name>A0A2R6NYZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000635">
        <property type="protein sequence ID" value="PSR80887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYZ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NYZ0"/>
    <dbReference type="OrthoDB" id="3248529at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="31574" checksum="624AC829B50D5B31" modified="2018-06-20" version="1">MPCLALTEKRSASAGPNTAAASSTVHASTITDAAYAPAVTTEPRHALPQTDPRQVVTPLDPDKVEMKLRELGILAQWQHVVDGLRLGFDVGASAPIPQSLQFKNHSSTELAPDFIDSYILQEQAAGRYSQAFNPDNLEGIIGAFRTSPLGLVPKPGSSKFCLIQDMSFPHNDPLMKSVNASIISDDFPTEWGTFAQTSELIMDLPPGSLAATFDISAAYRITPVIPSQQNALCIFWRGKIYVDRAVAFGLRSSAGVFGALADMLVAIYRASGFGPLKKWVDDFLVIRLPNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZD3</accession>
    <name>A0A2R6NZD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZD3"/>
    <dbReference type="OrthoDB" id="3014238at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="5944" checksum="059B1CDEEDAB62F2" modified="2018-06-20" version="1">MKPLQAQGIETFELDVTNSDSIASIRSRIEDLTGGKLDILVNNACVCIVMAYAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZU3</accession>
    <name>A0A2R6NZU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000610">
        <property type="protein sequence ID" value="PSR81680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZU3"/>
    <dbReference type="STRING" id="98765.A0A2R6NZU3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="231" mass="26225" checksum="359D06C0232290AF" modified="2018-06-20" version="1">MAPYALYNTPVYPSLPPDLKIYSFFQYKYRTAYDASRAFFVALFSTAVKFLDKLDGQFETRADLALAWRNLLEKDCREIRKELYDQVYAEAERLMRAGDISYNSVRIEGNRLKEAILARVIQDCPDDEPVIMFYLDEPQGLSSFATEDGSSVYDNFVSVAGELVGFGLFVVILLRSPTLAKRTPSKWPPFTELPFDCLPDGGYIFRPNTMSLADVAAISFMVKFGRPMYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZX1</accession>
    <name>A0A2R6NZX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000609">
        <property type="protein sequence ID" value="PSR81719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZX1"/>
    <dbReference type="OrthoDB" id="2804335at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="40"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="437" mass="50230" checksum="0BA85FA12B831FE6" modified="2018-06-20" version="1">MVGMAESKAMIHINFGNKPFKYRFQDFPSKKPLSEHSVSLSRLPPEVIASILDYLVPVIHPRLDMSHSPKYKHTLGACALTCRDWAQKCRPLMYRQITLYSEEDLDRLLDLMEDPSSPIPYSIRNLRLHDSSVKAWTYRALLIFSQKLLNLERIELVHAAEPNAVLLPQLTGTLLALISSFSKLRYMVLTNHHFETFSEFIFAISPLRNLEELECRAISWGGSVNIMQAAGTYRSSGCLPRITVKQCQDPWAFVWLLIAPSRWNKSRHQQLAHPTIAADDAMARLGQKWQPNSCEILMGRHLWGAHNEQMSILQDVLDVITMIWHVDRDAITAEICDVALDQDKTFACVTFRDYRTAVALLEQWERSGWTDGVGQRVAVEAWAFEYNPLPAIDVRPPTYLQDLLGSGPEMKPVCWLKRYERGWNARARRMRAREQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1I3</accession>
    <name>A0A2R6P1I3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v5719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1I3"/>
    <dbReference type="STRING" id="98765.A0A2R6P1I3"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="2"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR83447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="503" mass="56607" checksum="9E0007EBB7B40363" modified="2018-06-20" version="1">MTGTDEHGLKIQKAAEERELEPLAFCDELSQHFRGLAVKANISNTRFSRTTERDHHQAVHHLWRELDSKGLIYKGSHEGWYSISDECFYTDSQIIHVEATPSTEEHHISTETRSRVEWTREENYKFRLSAFQESLLAHFQKHPNAIFPPQHHSDIIATLSSPMDDLSVSRPSSRLSWGIPVPNDPEHTIYVWIDALTVYLSATGYPWTATGGSGKQVGWPPNLQIIGKDILRFHAIYFPAMLQALGLPLTQQLLTHSHWTVDQRKMSKSVGNVADPIQAIDEFGIDLVRFYLARVGGRFKDDVDWSHEQLDKHAREITSLLGNLLMRITSKKIQERTEGKPLTPAAEAFKHMKEDSPTLPLYQTFQGLGGKVEEKMDQLMLADVLEDIVITLGKVCASQNIISVISPFDSTQANQLMTNTAPWAATTDTQTVIELYVCIIECLRICGILLQPFMPSKAEMLLDALGVPAEERFIANANLGTGSVGQIQTGIRLFSLPQRQKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5G9</accession>
    <name>A0A2R6P5G9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v5305</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5G9"/>
    <dbReference type="STRING" id="98765.A0A2R6P5G9"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="18">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="17">
        <location>
            <begin position="171"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="313"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR85829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="368" mass="40482" checksum="FF48FA3660342A31" modified="2018-06-20" version="1">MSTPSFWLRCEKKPFERRAALTPTTAKKLIDAGFEIVVERDDQRIFDDAEYEAVGCKLVDNNSWPSAPTHYPIIGLKELPVSDDPLPHTHIQFAHCYKKQGGWSSVLARFYKGGGTLYDIEFLNDAIGRRVAAFGYHAGFAGAAAGALAFSAQRKGEKLGQLEPYPNEDAMISDVKQRLGGSGKGVRALVIGALGRCGRGAVDLFKKIGLEENDILKWDMAETAKGGPFQEILDVDIFVNCIYLSSPIPHFLTYDQIRQAGKDRRLSVVVDVSCDTTNPHNPIPIYSINTTFDAPTVPVDVGTGNPPLLVISIDHLPTLLPREASEQFSSDLLPSLLDFPKRDHARVWVDAETLYKEKLAEAVKAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P617</accession>
    <name>A0A2R6P617_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P617"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR85846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="124" mass="13753" checksum="464B6A02E940B67A" modified="2018-06-20" version="1">MKHTLRMERAAREQAELRWTEETRKRAEAERYVAQLEMRNMALENDLSSWTNAAADALVYQFDSATQPLSPTVDTQDVIDPPARTTMSLDTGDTKGKGETADLTAVGDGTADMSRDASRQCILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8Q2</accession>
    <name>A0A2R6P8Q2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8Q2"/>
    <dbReference type="OrthoDB" id="2737573at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="177" mass="20717" checksum="817FCB062255035C" modified="2018-06-20" version="1">MAFKSEPIEPSLPPAPIQKPPVDKEARSKALKIVTDYRRATAWQVHRWPYDKRVAEDKTKIHLPRSYLAKTGEDVKNVWAGADLNQIVHQHYIKTVKIEDLSTDRMKGNFVTPDNISAERHEFLGPDPRIAGYFFDVDGEIHVKWWDSFLQDQWMDKTKWKFDVRLGDDGKWVEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBT4</accession>
    <name>A0A2R6PBT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBT4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="7068" checksum="325903F505C775C4" modified="2018-06-20" version="1">MHRWKGRCWLRQLDLGVVHDEERDEDGENLKRDIRFSCAAKLPDNRRPYQRVGAYAEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC69</accession>
    <name>A0A2R6PC69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC69"/>
    <dbReference type="STRING" id="98765.A0A2R6PC69"/>
    <dbReference type="OrthoDB" id="549353at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905762">
        <property type="term" value="F:CCR4-NOT complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10910">
        <property type="entry name" value="PIN_limkain_b1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024768">
        <property type="entry name" value="Marf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379">
        <property type="entry name" value="LIMKAIN B LKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379:SF3">
        <property type="entry name" value="MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="543" mass="59269" checksum="360CEE13F0E1B879" modified="2018-06-20" version="1">MSSVEQDTVAIFWDYENCEMPASADPFTISNGIRRLSQGYGIVKVFRAYFEMSDLTSQRSISMRSGLQSCGVSLIDCPHNNRKDVADKMILADMLVHAMDHPAPSTVILISGDRDFAYAVSLLRLRKYKIVVIAPSTLHNSLKTQATTAYEWPRSVLEFNNNGCDLGLPWPARGRVVNASDVRTNLPVLIQGTQFVSEGPIPPNPRSPVFPRPDINCAVKGPVTPVRSDTIRHSRSPSLGVLSEKTTSGRALTTPSKPSFADAVSGGSAASIQTSLQDNNCNLSPVWRPMPVQAAAAPTSVTTDSSLTIFDEKQHSLGSPFSESKQPGESRDDDDFKIALNDEHLVPDLKAMDTQDGRHSDYSQESLEQGSPEFTFLSSPLALAGAERGSISSDISVMSPLAGIERDFVPTLQDPTGLAVHDSIQLNPDIVIPTVAMARLRRPPSKFKLLVRVLERERLRGNTRVVFSQLGSMLRAEHPSVYQRAGAAQLKDYIAMAEQDGVVIVGSSRCDWENGNKWTALHPVFHGKPQELLAQPQVVLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG77</accession>
    <name>A0A2R6PG77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG77"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR90697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="698" mass="77800" checksum="9046065BB8CF441C" modified="2018-06-20" version="1">MTHFSFIIARISELSYRLLFWILRMPSDVSPKFVVGVSPSKSQDFNNLFALLIGINDYTFEGSKLQEAVDDANNVKEYLTGTLDVPLRNIRVLLDQEASRADIIKEIRNLKVNNDIAKDDPILIYFAGHGTTAPYEGSGHHTVELILPCDYGKDENGRIVNGILDLTVSALLAELAETKGNNITIILDCCHAGSGTRADDGYLIRTVEGTIPVPRDLDEDIHSSVWHCGHRAIQTPSGFRSKGLNSHVLLAACGSQETALEKRYTGGLFTRALLVALKSVHPRATTYEDLMNKLRLPKIENFKQNPQCEGFYRRRLLFSTKESVLKSVPIYRIGDEDKEYKMDVGVAAGSIAEGDRFELYSDHPQSVISKSSPAILIAKKPNTFFTLLEIQSPTSPTDLPLKGFAVQTLSAIGDAAVLLVCIAEESLREDIRQHIAKSTDWRRNIQLVDQKTAELEIHTETDKVIFNLVPAELTCSLLRASSSSADICDVIYAARAYHYHWRRQGPSNNQLLCDKVDIKLVQVVEDTDTADDNLRYPYKVASCHKSRELRDGQSVKVQFNDKIYYGLEITNKSQIPLYCSVFFFDSDLSIKLRYQPGTSGQTVDAPLQPKKPLEIGYGSSGVTPWQYVAPPHSLSETDVGYLKVFLSTHAVDLSHMAQASPVEPQARHERSAQPTIPDLWGIVTIPVHQRNIKDCLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PGP0</accession>
    <name>A0A2R6PGP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PGP0"/>
    <dbReference type="STRING" id="98765.A0A2R6PGP0"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR90575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="283" mass="31899" checksum="431C66A5B3469CDA" modified="2018-06-20" version="1">MANTTVRGAQAIHGQNPQFLVETVIRNRIYEAPFWKEHCFALTAESLIDKAIEVKAIGGVYGNNKPTEFMCLLLKLLQIQPEKEILLEYLQADEFKYLRALAAMYIRMTFGAAEVYEILEPLLKDYRKIRLRNMGGYSLTFMDDFVDSLLHEERVCDIILPRITKRDVLEDNGEIGPRKSRLLDAMEGKVEKDRSRSPSGSRSQSRSRSPSRGRGVSRSKSGPPSDAGSRYVSRSPSGSRGGSKSPYRSRSRSVSPDRINGGSERFRSRSRSISPDRMETTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMZ2</accession>
    <name>A0A2R6PMZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v4675</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 13"/>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6PMZ2"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002469">
        <property type="entry name" value="Cell division control protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="15">
        <location>
            <begin position="450"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="713"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="764"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR93780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="927" mass="101687" checksum="B7E956C14AD83477" modified="2018-06-20" version="1">MDVDGMSSSPPLRHTSLPPSSAPQPSASSNNRSTPRRSRPVTDALALGDDDPEDVEAEEGAASRRKARPRTQAGVDIPLVKDAVGESVRESFETFLKTFTEEITLAATPASDGGVPIAADGELIYIEQIHTMREYELTTLYVDYGHLLQKDDVLADAIQKQYYRFLPYIRRALHSLVAEFEPEYLKLNPTAAATDSVNLQSREFNVAFYHLPLVSGIRDLRTDKIGTLMSISGTVTRTSEVRPELLYGSFVCEVCGGIVNEIEQQFKYTEPSLCPNPTCGNRTAWQLQIDSSKFTDWQKVRIQENPSEIPTGSMPRSLDVILRSELVERAKAGDKCVFTGTFIVVPDVSQLGLPGGNKAELMREASKAGANSAASTTGGSGVTGLKSLGVRDLQYKTAFLACMAHDADGRAGTNIRGEDEDGEDDGQAFARSLTGPEFEELKAMIDSDHIYSRLVESIAPTVYGHEIVKKGLLLQLMGGVHKETAEGMHLRGDINICIVGDPSTSKSQFLKYVCSFLPRAVYTSGKASSAAGLTAAVVRDEETGDFTIEAGALMLADNGICAIDEFDKMDISDQVAIHEAMEQQTISIAKAGIHATLNARTSILAAANPVGGRYDRKKSLRANVAMTAPIMSRFDLFFVVLDECDEKSDLNIAKHIVNVHRFQDDAIHPEFSTEALQRYIRYARTFNPKITPAFVREAYSLLRQSIIHVEQDDIDFDEEELEGERDGNRRPKASQEGEEEDSQDVEMSAAEIAALEESEQLYNQSMGTDGAGPSGSSGPGGSSSRAASVATQVPPAPPAQPKRRMVITHDKYIALQSLIVMHLSQVERESGRGVDRDELIDWYLESKEAEMQDVEELEYEKELITKMLRKLVKDNYLIEIRGDVQESLPSMDESGAQTSVDSQEGNVRVYYMVHPSVDTDESSSFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNC7</accession>
    <name>A0A2R6PNC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNC7"/>
    <dbReference type="STRING" id="98765.A0A2R6PNC7"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="494" mass="53196" checksum="C6AED7A14BA63978" modified="2018-06-20" version="1">MSKVRDSLFQIVRFYQLCGTVWRTSTPEPSQGDGIIWTYLKDVTRFIPLFEKPGTFILQLDNLLETGLDGQYATTLDATFFESSAQNPPAPRADVIIPVTTLANDTGNDASVPPIFSLNVTVPRNAVEIYAELQASGNGNEEFWYFNTANEFIPDLPSGTTFGDGPFREVRLLVDGQVAGVAFPYAVIFTGGIIPTAWRPITSYGALDLPTYFLDLTPFVPVLTDGNPHNLSIDVVSAESDHTINQNWFVSGSLQVKTDPSSKPTTGKITVYDASPFAVTSTTGSVGTNGDVNVTVQATRNIHIESEFTSGSGKTTHVVWTQALSYSNTQNYLDNTFIQNVQQIASGSFLSTHNGVATLVDDFSYPLDINLTVTSPDGSSFTATFDHSYDRNSIPGPFILGSNIQERQLAGGFLEETASGNFGNGTSNNTFSYVDLKGNTFDRQVSAINSAVVSDHQSGTLAPAPNVVSSKLIPSNMAIVKPRLPGGRTKGFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNE6</accession>
    <name>A0A2R6PNE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v4531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNE6"/>
    <dbReference type="STRING" id="98765.A0A2R6PNE6"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR94103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="619" mass="67567" checksum="90E00226010CEA7F" modified="2018-06-20" version="1">MIHEDHEPLLDLSDVVHDDTIAEDDQLLGSDDLPIDAAFHDLTGSSLIDDISPPHDVPSFIVAQLEREITSLLQQNALDGSTGLLTAVAEQREADPEKRNSQKNHAFARNQTDAMDLTDLNLGDLAAFLQTAHAQAAESERAAKALAAQHPELAWQRREQENQKKTTRAAPAFHSLNMDERRSGMLGGTESSNGSEYLYEHHEQSDVRNDRVASISGGSAAVISPEIPPVVGGFTDIGDILQDLSDFNHHPDEVHVGIPESSAAHLSTVNLALSNYRSSSTTPVDFDHIHLSEYDDTNDQPVASSSSGAGTGSEAEGRKRKKNKEKKRSSQEAGPREHVCEECTKAFTRRSDLGRHMRIHTGERPFICPEPACGKTFIQRSALHVHQRVHSGEKPHVCEYPGCEKTFGDSSSLARHRRTHTGKRPYKCEDPVCDKTFTRRTTLTAHMRTHDPTWEPDPNIKYNFKAKKPKLDPANADLSLEESVRAVSAIFNSQTDGEPSSSSLQASQPLGENMVASISAEIAAAIAKAQARILDDDDSYSESGSEYGQTEYIMPNTSGIRGEDGPWHVVEGEDRVSGGTELGLGLASVGGEDEGGFPVPLRTRKGKEPVGIIGLKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNI5</accession>
    <name>A0A2R6PNI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000452">
        <property type="protein sequence ID" value="PSR94375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNI5"/>
    <dbReference type="STRING" id="98765.A0A2R6PNI5"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52787" checksum="CA5688F0BE3A5186" modified="2018-06-20" version="1">MIYDEIARTCPRQDILPNLHSLSWYTVDAVRQQRSLVFMHSNIKHIALQLHRSRDTPLSKYIDGILERTPHLLKLEVRAEAPMRSIQPELLALYRGLRKLRHLVSPMYFLTSGIISELSRAEKLGIIEFAEPVEQGTGDRADVAHFAPALNDGAFPSLLKLSFSAHLQHATQFISRQFMPLNLSCLYLHILAIDNPAVLQQFLSIIARRFLVLTELHVDFLLGPDSPIAPPPPFIARPNLDTLRPLMACSRLKVFELRWDYQLNLSESDLEKLAISWPYLEVLKLNSEPLPELTPPILTVEAILPFARHCRRLRELGLYIDGEHVPARQSASPQPFHFLEALVLGSSPIGAVEPMALFLSQLCPLSCRIVAGVRWPDAFGIAMDHAGIMDDRRMKMPEWWVKWNDVGKVLPLAIQARLEERGRMTALAREMDMLNVCRREEKTRVEELENEVRELRGLMEVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNL6</accession>
    <name>A0A2R6PNL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000447">
        <property type="protein sequence ID" value="PSR94571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNL6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR94571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="148" mass="16855" checksum="F405890AA31D89B1" modified="2018-06-20" version="1">MTDVVDTKPDAEIDSDYDLYAASFRREAGELCHWILWVRLDEMNGVTIEADGWNGNWVTRAIGHHAPYQSAAILEFEIIGSIPVADWPAFRDNIPIKFPPDNRSEAWNCQSFIKTVVRDMDKRGWIDDGLRAELENGSLLHKISPELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNM3</accession>
    <name>A0A2R6PNM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNM3"/>
    <dbReference type="STRING" id="98765.A0A2R6PNM3"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR94657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="110" mass="12338" checksum="62224054CABD45CA" modified="2018-06-20" version="1">MPQRRFRPSQLDHVEDLEEYRPGGLHPVAIGDTFASGRYRVLHKLGSGGTSTIWLARDRQPSERLMTLKVMRAEQSAKAKDKIAELAIPQNLHDILRANDYIALSPTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVM0</accession>
    <name>A0A2R6PVM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v4329</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000438">
        <property type="protein sequence ID" value="PSR97384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVM0"/>
    <dbReference type="STRING" id="98765.A0A2R6PVM0"/>
    <dbReference type="OrthoDB" id="2499463at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="159"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="298"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR97384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="360" mass="40669" checksum="BDE998C7F1678FA7" modified="2018-06-20" version="1">MPLLADKTNKKKVIIVLTLDELEADQAQRFKQMGLTATLVNSQVWTKDLHKHPEFPKLIRSLDFMQDVAMIVINEAHCISQWGADFRMKFGELEKLCSYIALDIPILASSATLTPTVLAEVQQKLSYSADNTYLLDLGNDRHNIMPIVSHMKTARNLTALDFVLDKALCESGQPLVRTLIYVNTRELAENTWSHLARQLPADLQHQVEFIHARRSQRAKKRAMHRFCNGDIKILCATEVTGMGLHIPDINQVVQYMLPKTLNEWVQHYGRAGRGGQPAMGILLVELSAFKKIKVKKQVSEVSKPTNKQKVPNVPVESDSKDSNENDLECKEMADDGAETTNHDSISQYQKKVEAGLHEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVT6</accession>
    <name>A0A2R6PVT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000438">
        <property type="protein sequence ID" value="PSR97385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVT6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="8066" checksum="7591D9CEBDCA2137" modified="2018-06-20" version="1">MATLRKNNIHNNPNISRPPLIFAITPQQTTMQTTGLQWMPYATSTAFAMPLASIQLQWMPMNSDLYSLLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5X2</accession>
    <name>A0A2R6Q5X2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000395">
        <property type="protein sequence ID" value="PSS02522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5X2"/>
    <dbReference type="OrthoDB" id="2636032at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS02522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="198" mass="22759" checksum="2866F4F09EA4195C" modified="2018-06-20" version="1">MADWLESLDNLLKTHSVCLSTIITSLLTSSDCNIHAQTMKNDLLSSSSVVLSAFNLYPSTREWIAHTAYKVYTQELHALTRKENGWHFSAIHAEANQIEDFMLDDMVTQMEVLAPSLWHLLSALVTQKPSAKHNYGGSELDEEEEKYWRELDGLEDENLIARSRRNNEPIPTQQRATPRVIERRRTKILQTVSPMKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB39</accession>
    <name>A0A2R6QB39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000379">
        <property type="protein sequence ID" value="PSS05351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB39"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="17826" checksum="4AB2BC25DA1BAD50" modified="2018-06-20" version="1" fragment="single">MSANPEDLSYIHRRCVLVDKLVSLEWTHPPYDAEGQYDLPLISVGMHRLRDLAEEVYADLKAHPEVPRTPAPCLPFNLGTMELLAHIRAAALPSGPIIDIEDTPPVSPIEDDVPLTLETEIGSHADVLMCIAREIRDMHQNTAIAICSMREDVSISKLNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QB50</accession>
    <name>A0A2R6QB50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000379">
        <property type="protein sequence ID" value="PSS05345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QB50"/>
    <dbReference type="STRING" id="98765.A0A2R6QB50"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="52"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GAG-pre-integrase" evidence="1">
        <location>
            <begin position="172"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS05345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="230" mass="25462" checksum="E3B91169AB929FC8" modified="2018-06-20" version="1">MKHEEDERKRGDGSTAHYVAGSLQDLGVREVGQVYMAVQHGLTKSVQRKELLLDSAATFHMFCNAGLFTACRPLSESDPDRSVETANGGVSPIVRIGSVQWKTWLPNGYRTVVLHGVKYIPGIHANLVSLGVLQQAGATYTSFDSTHSKGVIVKLGKDKLFQAVLINPTSTLYCIDWFQSESAAAYAVRSTGSMRLWHRRLAHLSVERIQEMLRKEMVDGLLVSSPKEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBQ1</accession>
    <name>A0A2R6QBQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000366">
        <property type="protein sequence ID" value="PSS05558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBQ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6955" checksum="A70840CF93BA0A0B" modified="2018-06-20" version="1">MDFVVSATPAGWARELTRYRDHYLPLPSSIFTATNLTVAGRRGTYSVAIAVHKRKIDSVYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEP9</accession>
    <name>A0A2R6QEP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEP9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="13598" checksum="C8F15090C2076DED" modified="2018-06-20" version="1">MTAGLDALNCAQKDVHFGTTLEEGKIDDLDQAPSYKFVSSELRTGAMEVTRSFAPCAPYGTRLQVLFLPKSGARTERVKVGRGRLEKSTLIAEESIRVENASVWAPNLEECPIKMSHARSWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF05</accession>
    <name>A0A2R6QF05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000344">
        <property type="protein sequence ID" value="PSS06894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QF05"/>
    <dbReference type="OrthoDB" id="3266963at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="374"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="871" mass="97839" checksum="B2E9B0570E7FFFF2" modified="2018-06-20" version="1">MYTQTGPLDGILDLIKKRGTLGDFLIELFTVSSRADASRSQKHAQAVSKFLGGTTLVDPAAIVNLMYTSRDSFPIPTRKSATPAELKKRSDHMRMARYKLKQWAIGVVEEVIDAEADELMSKDGGLRLPADITWDFLQHFSLESIMSVAKQKSPTLVRLLTAAAIPSKKRTSPSSTVNLSQPLASSSTIIPPSTAITPSMSTAANPTVQPHSSTAADEPLQLFSQPAESGLGHNRRNPFIMIVVTLLMLMNARNLQFTGFQKLMGIWLFANTASSYIYTILGRMGLCVSYTTTHNLLDDLSQSAQDMIRIKALQHAFLLIYDNINCMLRVWDPELGEKDMMDSGTAATFVELEDRDPKMAFDIDTLERARALQKRKSLSFDVLYERVKWDVLHEAMAVHTLGFLVQHVPGLDYIQESLTKKLWTSLAVHRMQQERKTTLYPLATSDHDEGSTGGNQKVIDDLMLRQLHLNKDEAAKMLTIVGGDQATTEKIRTLKCFLDGCPHGYSSYHWVLPLIQLWHMGWADLERILSTHWSKSNVVSDISSFCFVNEKLGRKVKNIKRPDFYPAQALVFDTLHAEVLDCWQEVLKTDNLVLYFEQNSLGLEELIAIAKKIVYNYMSTLGHEKALHSDNSAGLFQPGTSWTNSGPRCLCDQVLSNTVLRMRDSMLHYEFQHAVADGDIGRAMNVMSVWTFTFCGSGKSKYTNELLELSCNFEYEYSDALQEAVLNNWLYIKESLQIATGITKKRGGHQRKKKMIGLKLLAQTMKEHQLHRYRKGRTYNHEACDDFEAGVIALDKTTRIQDFVQRTLTNASNIHGAEDIQMADAGIEDAEYNDEMKELPLPNILRHGVLLSSADMLEIGEDTTEMDAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXL1</accession>
    <name>A0A2R6QXL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v3233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000297">
        <property type="protein sequence ID" value="PSS17128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXL1"/>
    <dbReference type="STRING" id="98765.A0A2R6QXL1"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="141"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS17128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="520" mass="58634" checksum="D29CBDCAF099B124" modified="2018-06-20" version="1">MASASATGKLSREEFRRQKDLDAARKAGTAPAAVDEEGKVINPHIPQYIAQAPWYLDTGAPSLSHQRIPEYDRSADKLDNWYDRGAKAGPAAKKYRKGACENCGAVTHKKVDCLERPRKRGARFTGKDIAPDEIIQDVASGYDAKRDRWNGYDPSEHRKVYDEYAAVEAARQKIREEEIDKQTTTDLAAVRKVAKAGKGEEKKDDDFGSSDEEDEDTDKYAEAADAVGQKLDTKTRITVRNLRIREDTAKYLINLDPESAYYDPKTRSMRDNPLRDVPEEEALFAGENFLRYSGEAPDVQQLQLFAWNAAARGNDVHMNANPTQGQLLHQEYQKKKEQLRDSTKVSILAKYGGEQYLEKAPKELLQGQTEEYVEFSRAGQVVKGKERAKARSKYLEDAGIEAAKASSAQNLLASSSKDEPSEAPKPDLGGSDDRQKKAEELFSKRRLGEGEVKIDESKLTQALRAERERKRKGRDEEEEWGGKKKKAGDSHEVTEEELEAYRMNRRMTEDPMANYVDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM30</accession>
    <name>A0A2R6RM30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM30"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="7748" checksum="2D3834D61342CAF4" modified="2018-06-20" version="1">MPISQPRPRLKIPPDIIPTFLAVQGSRPSSPLGLLSVGSLLLSPGPWRPMTTIYDSQELATQGCNTTAYQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPJ4</accession>
    <name>A0A2R6RPJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000213">
        <property type="protein sequence ID" value="PSS31941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPJ4"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS31941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="14043" checksum="007C167C4CDB8B42" modified="2018-06-20" version="1">MNIAQVLVDTVPSLQISSPVTIIFLVLNPILISRFLLNLRQLDEPKNERQSRFNSQYSIPGFRVPTSTSIVGNMGAELDHGPAEEADNDSEDAGVESRNEASVNGAAENLPGAPFTADVLEVLEVPRDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPR5</accession>
    <name>A0A2R6RPR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS32018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPR5"/>
    <dbReference type="OrthoDB" id="2754196at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="79"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="645" mass="72549" checksum="C26473FE68E83368" modified="2018-06-20" version="1">MPVAHAATTIALEHPISDPLTSLDSLICSWDSVSEDRLAAARALIRQARSQPRPANEDSCIRCAQCISKMLPTVVHDAPITLNSLPNELLLKIFSQLVNDQWNPIASSLVALQDTVDWLAVTFVCRRWRTLAIAASELWTRIPVVTPCMVAAFAERSRDRHLQLIVSNTDRMPDALQAAMRQLPPLLHRVTHFSFITSALDRRCLQLMSYLPSLPATETLYIWYTQECHTEATNHLVAHFLSKAAPRSLRTLYLRGCWFKPTQLSNCPDILDLSIIHDHIGIDSATLVDVLRHVPRLRKLQVKSGGKFNPWTVLDPQPATQALVCLPDLEVAEIQLHSHYMERFLVPISFPQHVQISLVASGTDTDNALMTAIQVMRYASGSLCSAGQYTHVRLAVDRHRTEPSRRVFTLHAGFNRHETKIRLQITYSNSSSSLSHKRPLSFLEITPFVMRSVTTLILDAEPLSPSASPHAIDHDYVGKRWYQVLHALPYLVELQITTHHVLSHRELFRRLGEKSVDGLTVWLSSLRILHFKDLVLRGEQCTCGCTVAEDKRGAYGVCNAVVAGVFYGRRNKAEFDSEHPDSAVLWIEGLRRGLERRNANAAPPLSLRFSASSPREWRRSCCHHADIARVIRPLVDTLEFLAPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQA8</accession>
    <name>A0A2R6RQA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000183">
        <property type="protein sequence ID" value="PSS32218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQA8"/>
    <dbReference type="OrthoDB" id="3268677at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="227" mass="25374" checksum="7FF76BC73A6AF4CD" modified="2018-06-20" version="1">MGACLLECQRYGHELGVRTSEGNAKSGGYKIGGVSALGNHIALYRHIHRITFEEGSPLYHWDIEKLDRQDDDKARTKMHKGFLLEKSSAYPKARAVRYNHTYMDSCGMDLQVLGRYPTSKEISNIACVAFEEAEALVALLGLVPAQLHRDDPMFVSLPGFDSLLHDGFSTDDKPEEYDDNDPDCAAKLQSLLQEDHWHRGLSDNDDEKLTSLSLAAMSLTIDEMLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQD1</accession>
    <name>A0A2R6RQD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000179">
        <property type="protein sequence ID" value="PSS32220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQD1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6374" checksum="4A88D6889D119209" modified="2018-06-20" version="1" fragment="single">AVRKIRAEMAHSAAGCPKSAQNGRLEAAHGRPKFRTFPDGLFGRFRGSWSLSAGPRFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQE2</accession>
    <name>A0A2R6RQE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000179">
        <property type="protein sequence ID" value="PSS32235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQE2"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11324" checksum="DC049FABBFA9526D" modified="2018-06-20" version="1">MQPILISRFLLNLRQVGSPEIDSQEAFDSRFSVPRFRVPSLASIIGNMGEDLDHGGSAEEVEDEAENTVTSGSIQVEEGAVPEAIIDDPSSMNSIPSTSRLIHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZE4</accession>
    <name>A0A2R6RZE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000137">
        <property type="protein sequence ID" value="PSS35349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZE4"/>
    <dbReference type="STRING" id="98765.A0A2R6RZE4"/>
    <dbReference type="OrthoDB" id="3254269at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="291" mass="31571" checksum="CD09CBAE0ACAC633" modified="2018-06-20" version="1">MAASALMELELVIELFEKGAPSSLRARQALSILRELKIKADRSYQQYRNRHASPALDIQLNIGPEAEISASRLAIFGGQTRVMSSKLLSRRRPQHRSVSSTSSAPESPKRDDSPGASPTASTPSDTSTVPQNVSDAFAEVHPSLVEYLSLFPASSSLAVVDPSQQPYTSSSSLATPMAQPMENHYAQPMDGVATSPASAFPDFFSGLPAQRNQTPGVQQTQRMQVEEPLGFLNDQSLNALNMQDLGGFTEDVLMSEQWMNLMKETGILDSNGNFVGMQTGDFLPQELSGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZE8</accession>
    <name>A0A2R6RZE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000134">
        <property type="protein sequence ID" value="PSS35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZE8"/>
    <dbReference type="OrthoDB" id="3025610at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="389" mass="42925" checksum="8E8EFDE7A261E302" modified="2018-06-20" version="1">MSAASKSAAPRIGASKPPAIQQKRSAPESGSDIDAGPRLCSACNKPILGSLTSFRWCEACRAKDRERSKAKRERKREKNEELLKALSLIRERDSQRAAEPSEIPVADAGKSRKHVNRHMDPDTSKAVSKKQSKRKEIPGGETGKRKALEWESARPAKIPRVSKSTSQADLSEFQTSHDLYDMLSGLVKSYYKACTSPSVPCVNISFQGSYSVVADPNISNSRRVRMESKYLSKIIKLPHSETGGVNDTATKTHWFQDFRCDCGRRSVDGLPHEQRKQAQPAPSTSKSSIHNVTTHSTLSSTSLSQGPRFNMLSVTHTPFPSKVAGRPLKRQQSDLSTWVLRAGTPSPAVEEQECGGRIRIISMDDVSHQSGHLFKGQKITIIVEHAQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZI0</accession>
    <name>A0A2R6RZI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZI0"/>
    <dbReference type="STRING" id="98765.A0A2R6RZI0"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="4">
        <location>
            <begin position="163"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS35423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="763" mass="85950" checksum="872F49056726C4D3" modified="2018-06-20" version="1">MHLYLGENPRTLYLVTSSQDERQGRPRRALVFRSADGRPSQAVVEFLPKDEVDLTNTVSLTNRVVKGCLGLISISGDIFLAIVTSATEVGNTRPSGLRNESVARIHEVGFYCLTSSTWDDLPSAYDSVPSSNYPDHADALLRDSYSGSNTPNPAVFEHPCAPLTKIISSGTFYYALEPYWDLSSRLSQRLAREDNIARDTGTYDDRFIWNEYIVRSLLDFRERLDHQERDDIDKCQFIVLAIQGYVGVHNFPLPAPPTNGSPMVATVSLISRLGWKRAGTRFNTRGVDDDGHCANFVETETIFSTDMNCFSYVQVRGSVPLFWEQQGLQTFGQRIQITRPQASQPAFERHFLQLTEEYGAVHAVNLLGTKENEASLTAAYARHLQIARNTFGNSIGLTNFDFHNAVRLYGHDNVMRELRRQESITDQVDKFGFTMADAGSADVITLQKGIFRTNCLDCLDRTNFVQDILSRTVLEQYLSLIRREWLHSGSLWSFHRELWAENGDALSRIYAGTGALNTSYTRSGKRTLAGVLSDATKSVSRAYINNFQDKGKQVAIDMFLTGLRGMSGNKGAVAIRLEYYDTDFCFITAHLAAGHSNVEERNADYHTITSGLHFLKGKTIDSHQNVVWLADTNYRIDLENERVRHLAETDDFDALLSADQLRQAMDEGTAFTGYMEGPLLFRPTYKYDYGSDNYDTSEKMRIPAWTGWEFPKLKYGSSLTLELDRILFKGNALDLSIYARAELKGSDHKPGTFSGLLYIMICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZV2</accession>
    <name>A0A2R6RZV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000121">
        <property type="protein sequence ID" value="PSS35527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZV2"/>
    <dbReference type="STRING" id="98765.A0A2R6RZV2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="198" mass="21404" checksum="F4C688668D51A1E8" modified="2018-06-20" version="1">MRRHWRNHVSNSRRRDSVARQIETDLPAQMPPTPPLSASAASSPRSHYENSLSSSLASSSGAHNSRLPSPECSASEGEDGDMEMDSRDSDVTVTQALHTVSTLSIKAETAWDMSVSAWNTAASGPRHDKWRQRSRSSPVPRYREVQPESSHPISATGVSRTRSSSCSVPGCDCQPVISTTLRPAFPSSSIRSSAGQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZX1</accession>
    <name>A0A2R6RZX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000121">
        <property type="protein sequence ID" value="PSS35529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZX1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10911" checksum="446A9E6DDF6C068E" modified="2018-06-20" version="1">MTRSNPPNSSLPRFQFVVSQLSASVVHDNNQALAAVDHPRLPSFTSWFSSVPEETPMHEIERAFGQNKEKSTAESEKPTARAQNKKYKCGTCGKGFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3B4</accession>
    <name>A0A2R6S3B4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="1">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIF6</name>
        <name evidence="2" type="ORF">PHLCEN_2v1408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <text evidence="1">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3B4"/>
    <dbReference type="STRING" id="98765.A0A2R6S3B4"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="245" mass="26285" checksum="F3E407F1C2B7CA49" modified="2018-06-20" version="1">MATRIQFENSSDIGVFAKLTNSYCLTAVQGSTNFYSAFESELGDVIPIVHTTIGGTRIIGRLSAGNRHGLLVPSTTTDQELQHLRNSLPDPVAIQRVEERLSALGNVIACNDYVALVHPDVDRETEEIIADVLKVEVFRQTIADNVLVGSYCAITNQGGLVHPKTSIQDQDELSSLLQVPLVAGTVNRGSDVIGAGLVVNDWCAFTGLETTATEISVIEAAFKLQGQTSAAVIGEMRDSLIDSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3C9</accession>
    <name>A0A2R6S3C9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paladin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3C9"/>
    <dbReference type="STRING" id="98765.A0A2R6S3C9"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14496">
        <property type="entry name" value="PTP_paladin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121211" checksum="E61DD38C7B140220" modified="2018-06-20" version="1">MVAACLVRRKQLIDQGIEDPFITRPGGHKSGISTIADSKIVQAIEQASLQQDLNRSLLRITSILQQNLQSKNSQSAIELLLTQPELLNSLRKAHMGSYGVILSLLGCLEQGVKAKKLADRVIDSCDQVTNLREDIFLHRLKYSLTTTMDEAERENFLDKAVKALEKYFFIIAFANYVEDTTDFNQGFSDWLKTRTEIWNQIMFLRKTYGSRLNVFQPISDLSALSKSGSEGRALIAGQNNDVAISGGQILGDEYSDHVVQNRSGIILREGTLLKSDQWLRESHQVVDGVRGAINFRNIPGTKIYALGQPSLQAIDEVVARVRGAHPNSEGILWITLREEPIVYINGAPYCLRRERFSLRNMKDYGGISASRLGVLEERLRDDVISELNSFGGRLLLHTETPDGSVIPVWEEVNSEDVSVLKDVMASRKQLKGGAELRYVRIPITAERPPDFSDLTELIDVAVRNPNVPIVINCQLGRGRSTMTSVILVLIQKWLEAAAKLAIPSAPRMVRSVTATSLVDGTEGHRSDRHSYQTINNLLRVIRKGPTVKNAVDDAIDQCAEVFNLRDTIEESRARAEQASDEKQKRQFAQRGLQNLRRYFELIIFQAYLQSIHPDTLHSFETIESFVKERPVIKTFERELMADGINALKPLERVQVKDGVALPDEVQQVVANRSGTILSASTILKSDFFSNLQKMTLPERIDGSPNFRRVPLSLRRVRSGSSTPDQSEFVAATEDGRWVCGSGMPTLQGLRRALTRVDAGPDGHNVVYWTSLREEPVIYVAGRPHVLRLVDRPLENVEATGVTTEVVERMEEKFKSDVIREVQAGNGRILLHDEVEERPGVFSIIPIWEEVSEDDIMTPRNVFELMVKENYRVDYDRVAITDEQAPLPDALQQLLNRVSSGNDAGDFVFNCQMGRGRTTTGMVTACLIATTANWNKSTDDIASPEENGLDIYDSIDGPSEEEAYLEGEYKTILQLVGVLSHGKVAKRLTDQAIDMMQDVQNLRKAVYDYKLKVDASEKGSAKQRKLLNLGINYLYRYGTLIVFANYLIELREQDGPTASFPDWLREHREIAKLLSRRSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3G9</accession>
    <name>A0A2R6S3G9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000106">
        <property type="protein sequence ID" value="PSS36826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3G9"/>
    <dbReference type="STRING" id="98765.A0A2R6S3G9"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="272" mass="30689" checksum="2C2CE4E089B9869A" modified="2018-06-20" version="1">MDGLPLEPEPSDFVDEGLYRNYHPKLTGRPCDQDGKFLDPATPPPPRTQASRHDWTPYAARIQFDTAKFLYQRTQMSQGNVDLLMDLWAASLLRFGGEPPFANVKHMHELIDSTPLGDAPWTTMEASYTGELPANPPSWMTAKYELCFRDPRVCARNMLANLDFAKEFDTTPYREYDGRMVRQYCNLLSGDWAWEQADLIAEDPDTHGAMVVPLVLGSDKTTVSVGTGDNEYYPLYISLGNVYNNVRRAHRNAVLVVAFLAIPKGEQSNHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S411</accession>
    <name>A0A2R6S411_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000085">
        <property type="protein sequence ID" value="PSS37027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S411"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="129" mass="14253" checksum="E2CE689095CCC8EB" modified="2018-06-20" version="1" fragment="single">VSLVVSTLPAGVFLIKHIPRELKSPFCALPSYSTMSANPEDLSYIHRRCVLVDELVSLEWAHPPYNAKGTMELLARIRAAALPSGPIIDIEDTPPVTPIEDNVPLALETEIGSYANILMHIAREIRDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S471</accession>
    <name>A0A2R6S471_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S471"/>
    <dbReference type="STRING" id="98765.A0A2R6S471"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="176" mass="19399" checksum="C8890F781BB2DE5A" modified="2018-06-20" version="1">MQDEQPFKISVSQNALDSLAQKLAIATLPAPAPVTYTDSALDSEDWTYGVPRPILERLLTHWRTSFLPRWQEHQAVLNALPQFTRSIEVDGHGVFTAHYVHKQSTHTNPKGAIPLLFLHGWPGHFNEVSKLLPFLTTPPANASYPSFHVVAPSLPGFGFSSAPTKTGFAVAQYAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4L4</accession>
    <name>A0A2R6S4L4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000070">
        <property type="protein sequence ID" value="PSS37234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1329" mass="146961" checksum="83B9558CF75721E6" modified="2018-06-20" version="1">MSSRPKDVRGSPDKAGRGDLEAGLFAAVLTPLLVESFKTMSPDPNETEGDVLRRISNQTSSYRINDRFLNSTVPPFPEGSPSFVLPRFALSINVLWFSSLTMALATASFGLLVKQWLREYLSIESTNAKMRLRIRQFRKGGLKTWRVYGIAAVLPFLFQLSLGLFFVGLCFFSWSVHQTIGRTITSLVAAWAFLFIFAILAPVLSARCPYKSAMAKSILPALRKGTCSNIVFRWFYVGPTKRIKSSKEKDDKIAPFEDQDAAVDPIHDVDILTAADAILLDDDLLAQTMSTSLRNTRAAPVDIVDFVVAALEHRLLDRVSITTPIESLDLGGLEEQARTALVQIVTQTLEHKPAEHTIESWGWVNDAIAILLASYPNPLASQATSALISCMEAALIPVCKVITDRRLVITPTFHPPLYDAKFVGSSMPIYEASDIRPHLAHIFRELRHKFKELNVEDTLYALYSIIMATKDICDGQCGSSPHDSKELGALLRAHYACIPSTEVRDILEDSMDRHRSEMTQVGSWTPSASDFGLLFAAHIVRRPKGQDDCPKLLGGFVENIVLLQGQEGTSPADLSLRALRGVFPKGIPSARLSKHCDISPAARDTVIENIAKSLIQRLQDVNNQWDDTTGDTLAIIVGLCDTPPDASSSAAQALAYCVESSLKATFETLGSHILAYCVESSLKATFETLGSHITSLKVSAGLIFQICRNAFKVLNVGDTLFALYTITKIICNGQHGSSPHTCTKLEDILRKHSEYIPSTELWDILQDCADRRHSEVVQRDRWTPSDSDFDLLIAAHTATVGLDGCSKLFGVFIEDMISLQDGTDLPLVADLSVRALRNVFPKGIPSACLNTYCDISPATQNIIIESTARRLIQRLPDDNTQWNVDDDDLGDALAVIVGLCSIPPDPNSSAASAIKRCIQFWPEATSTILGFHNTLSSDISRGLSHIFGRLRVELDLLDLKSLLGFILTTIRNNPILCDETCYHQSDDLGSLMLEHPELSQSDVLADIIAERRLLRHPVDEPALFPLYLDLVVAADISQKDDAFLVEFILPVVLEKHQHTPSDSMQFMLSLIRNRRKQNVPVGDMSEVFDVAASPGVWKAIIDSIVAILEYAIPADLDAVWEEWMKDAFIILLSLPGDGLTAKANVVIERCAGAFNNWDSTMNKLVSESLSSIPVFTAYQIYFSIFKRLRRTPSIHLSSQSLVQASTRFIRGMICHETCGHGAQLGDIFSAHRHRFQLFSLLVDFLMASGPATHELDGILFSIFSSNRYTMGGTLQEIDPPGILEEFYANLIISASEVAIEDIFVLDYTYGRLGIDDEMGCQRPKRKYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4N4</accession>
    <name>A0A2R6S4N4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4N4"/>
    <dbReference type="STRING" id="98765.A0A2R6S4N4"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="93"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="93"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="431" mass="48013" checksum="7012E16C91B7CF4F" modified="2018-06-20" version="1">MPVARILPSRRRSRRLASRPPTDTEYQDSDFDLQSESPRSSDASSFSSLTTPISTPASSPTSSPSSCATSLASDDESVPSARSHSSKKASNHINRPPNAFIVFRSELRAEEKRRQEEESIKREERKRRAKEAGIEEEEDKQKNAITHSLSQFSRMAGELWQSLSFQEQQPWRAKADRMKLEHMILHPGYKYSPNSKAKAQKKRRSPGNTKLRQKRSKVVVELEHEGYGGDEIDNLVSTLEARLGVGRKTRTSAPRTKQQTRTRQSQSQSSASSSDTPASSRRTKAAKVAEAFISSSLPSGQETLSLEVADTQGSPASAQGPLFVATEDTVAFALQGSSPEVFHQDENYFGQSFIDSFHTTAVPNEFYAFDYDQNNTLDFAGFTDLPEVNSEHPYLLSNNLFDSYNEFTPESFEPSIDVAMGDLGWSNFPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5Z5</accession>
    <name>A0A2R6S5Z5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5Z5"/>
    <dbReference type="STRING" id="98765.A0A2R6S5Z5"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="563" mass="61852" checksum="7E913C330A05D96F" modified="2018-06-20" version="1">MSTHWRELVADKRRRQNESIPKEWLITTPPQSLLDVTKVPEQCGLLSAKELDITNTVDVAVLLNKLATSQWSAVEVTTAFCKRAIIAHQLVNCLTEIFVDRALARAAELDEHLKTTGKVVGPLHGLPISLKDQLPIKGLETTMGYVSWIGKYATRDAVLVEILYDLGAVPFVRTNVPQTLMWGETYNNVYGRTLNPHNRTLTCGGSSGGEGALVAMKGSPLGVGSDIGGSIRIPSYMCGTYGFRPSYGRIPYAGAVNSMEGQDSVLSVLGPLSNSLSGIKTFMQAVISAEPWLKDSLARRKKWDNDEYALVEHGSGKQLCFAIMWNDGQVIPHPPIIRALEMTKAALLAAGHKVIDWQPLQHRELCRLVYLIWTSGSGEDYKAVTAATGEPVLTSMDIVDENSEPTGTLNTFLPEQQHVSAYQLWQVQKEKTALRQKHLEHWNSTVQSTGTGRPVDAIIAPVAPYTAVPHGMNKNRRMTSSTKGMRIPMSYVIALSSIRFREFIRKANTASFYLPDDPATFSDAPVGLQLVGRSQEEEAVLAMTEIVDSALSQYKTSTSASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S643</accession>
    <name>A0A2R6S643_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S643"/>
    <dbReference type="STRING" id="98765.A0A2R6S643"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="83"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="432"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="779"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="941"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="969"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1074" mass="117712" checksum="CC3A774C3532BD38" modified="2018-06-20" version="1">MQPNHGQQSHHPSESQQNGHSNHPPNGHGHHNNGSAQNPPSSHRSASNQVSKEPINALGIPSVTVQNNELVVGDSQSCSTRSYTPLKVVGDGSFGTVWLCDWHGTLPPNTPLSAMQCGAGARPEYAGKRLVAVKRMKKRWEGGWDECRRLKELESLRAISYHPNIIPLYDFFLLPASKELYFVFESMEGNLYQLIKTRKGKPLAGGLVSSIFHQVIQGLHHIHASGYFHRDMKPENLLVTTTGLHDYRTLIPGAPPDAPLERDVVVIIKLADFGLARETNSKPPYTEYVSTRWYRAPEVLLKSRDYSNPVDMWALGTIMAEVVNLRPLFPGQGEIDQVARICELLGDPIDDYGLDERGKPRGGGKWPRGVRMARTVGFAFQKMRPQNIYALFDPNVPIRLVECIADLLKYEPELRLTSRQCLEHPYLLETIPLNNSPGPPSQPPSQLPSPCRTSARNGIVDGISPNPSLRSVVPRSIPPSHSHPGGHPKLHPGPSPHLPQHIPDASSTHRSSFYDSGFASITRRRSISETSQQTSEFSNDAFVPHSSEVEARRHPSTQDHVYSHGPNRRAHGNGWSEGDGQSDWDAMDVSPQVDVSAEPPYVTTHHPMDIQTSPIVPEYPARPAHEPEPPVAQAATQAQGNKRPILGSLNFGKKHARWGLGMFGHNDKHTLPPVHEHGLASTSSTPSLKRRESSSTDSRSLSELSPASDHPRVPPPALISDDPKQRKKELERMAKEVQKEADRQRRLRAEKTQREQARAVMKNNRRLAHAAVVNDFQWRSGPHGSGLPSDSQAAAPGPIRQAQSYGPSSLTVNAAGGSYKSPSQSPVVPSAESSSMARSDWRRDNERVAKARRRDYDDDHSMSSDVHGSMSVISFATVDSDPGPPRLRQRPSAYGMNRMTSMSSMRGSSSIEDYATSGRSSTSLSVEQQLVNEFHLRASVDSSSISDGGSPQPPPMHMLSLSSPIPWLHSQSDMSSTSTVDNNAAPSPRQPHQLNPTMISPPPQPRHPGPLHLGPQSPYGSGGVYGPPSPGLAPKSAINPMFKVLEAVADGGEYPPLSPMSFTIPEEEILSEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S686</accession>
    <name>A0A2R6S686_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S686"/>
    <dbReference type="STRING" id="98765.A0A2R6S686"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="368" mass="39979" checksum="9E4D0FFE8C60D508" modified="2018-06-20" version="1">MVGTSSDAQFPDALSFKCAVTNSKGPRRFMEDAHSIVVPFAGVHGQGFFAIFDGHAGKHAAEWCGQNFSLHLLESLRKFPSDNVPDVLNQTFHSVDNALTKISEESDGKMHSGCTAVTAFLRLEDAEGRQTFIPPDFDPLTAATDLIEGDEDSSSGESPETAKSNGKVKKRSKLKDALRSLGSSSHSRHASQPASSPPSPTSSFENVRVFTPTPNIRVRRVLYCANAGDARGVLCRGGKAVRLTYDHKGTDKQEAKRIMDAGGFVMSGRVNGVLAVTRSLGDSAMKEFVVGAPYTTETELTDEDEFMILACDGLWDVVEDQAAVDFVRGTTDPKQAANELMEEAYRMYSTDNVTVLVVRFRNPPANFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6S7</accession>
    <name>A0A2R6S6S7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v184</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS38001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6S7"/>
    <dbReference type="STRING" id="98765.A0A2R6S6S7"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="15"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS38001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="979" mass="107466" checksum="604D7F0673389F67" modified="2018-06-20" version="1" fragment="single">DSSVRYVLSGAPSGWSAMAKSVRDVDEERIKDCKEDIDTLMVFAGLFSAVMTAFIIESYKNLSEDPTTTTNMLLQQISSQTNSYAIHDGFLNSTARSTASSQPFEPSLAALRVNILWFASLIFSLATASFSMLVKQWLREYMAGEFTSPQARLRVRQFRHPALSHWKVFEIAAMLPILLQLSLGLFFLGLCFFTWSVHPSIGRTTTPLVAGWAFLFLFATFAPIFSSRCPYKTTLLKDTMKSVRRLLCRIVWLRILYIGPQHPRSKSLSKRTNNPTRPQSTSLADSLVAHHDGTRDPPGYIQLGNVSGSPLGSNPFNTPNIAPITYDNPLQRPVYQSGTSYELQDAGKFEDNVQSLLPDSLSRFPNPVIVNPPQPDINQPVVASTPVVEAITPHANQSTAVSISRPGDISIRDHTQAPDLQFIEPLEDEDVALDVSGDIRTFVAVDEIMMLDDNLLGTTMRESLQQSTEADMIKFVVKAAGNRLHKPEGIDLSSVPDMRSLGKPGWTSITDITADAVLRLLAELEHGSHGPDWAGLVDLRDALMILFARSDYPLTSNGNRALSLCVSGNPGKIVRTLLHDLPQDAMLERLHGALVMLPIEDAMPTLTALAGEVICRQTSHHHSELADFVQVHVELHADTLHAMLNILVDCVEYIFTHTRLEATGYSTWLEYALRAILSAHIPSNRRAEVSKLLARFLCERRSVISILFTIISSKATHRAPIVAAERNMGYAFIDSDSAGRRNMLTNVAGMMESMAKDFGNPAMRHFVPPIDPVRMCHLATTMMKMTDTSDLNNEWEGLFTATCEAIRNCPDEIRSEQETKDREVLVKECLNVFENLVPSALSDTQMGVTPGFSSPFLIRVINTLKTFNSPDRPPGFPVLHGPQQPEGGSMAGPPMPPSLTGMPPGGIMAGPPMPPFTGMPPGGILAAPPVNPGFTGPGMPPGGQGSEMGEFEQTNMAVMAIRSMQEVTGMAGPPRKYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S777</accession>
    <name>A0A2R6S777_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v33</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000002">
        <property type="protein sequence ID" value="PSS38126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S777"/>
    <dbReference type="OrthoDB" id="2747460at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47895" checksum="D9255A59C66BA3B4" modified="2018-06-20" version="1">MLLPLPYNEILSSPRSSTGFIPPEIVHMILLHIRKDRYTLSACSLVCQTWRYIGQSLIFRDFHVTIGLKHSFPDFQNFMATTPDISKHIQKFHLHLSQQLQVEATYYPIRPRSLVNLFERCASLREVYLGGIFRQFALDTVPQCSRPLRKLVLYDVGSVDALLVVMQLFPLIEEMHLPQMVSIFSITDAGLHNRILPPTLPIPAFVLSHSSAVAFLADIAKQGCLLDNIHSLKLPFAIEPRKTTFPHSVPDRVQLSNLLRHVGRNLRQLELRFAAEPLISDGMDVLWKNFDVSSCTSLQIVKLTPQSRPGVTFATFFQRMGDIPVHSGWESCVWLLVRLPETLQSLQFILDDVSKMSGQLSDGNWTKLQDTILRFPVLQTVEFMMEDKVNGDSISLNEYEIPLVYQILPMLKEAGLMRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDU1</accession>
    <name>A0A2R6NDU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001350">
        <property type="protein sequence ID" value="PSR70486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDU1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10085" checksum="59D6886C8C229F40" modified="2018-06-20" version="1">MRRLDQGPRNEHRRAPDPGHCNQARFALGVQASSRSVTSISLLFSKLHPPISPGLILAIRQDICNKEGLSHYSGSFFSSRPSDPEHAIGVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEG3</accession>
    <name>A0A2R6NEG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEG3"/>
    <dbReference type="STRING" id="98765.A0A2R6NEG3"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="34"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="20302" checksum="DACDDBEDC0C7D761" modified="2018-06-20" version="1">MAAGKQPEEYGIINQKGLSRKVMFFPINNYAINNNLTPFISMQNHHSLVYREEEREMFPTLKLFGVGAIPWSPLARGLLTRPLNDLKATSRGQTDPWIKGYGGSGTPEIINRVEEIAKKKGITMAQVAIAWSLSKEGVTAPIVGTTSLKNLEEMIAAVDIKLSEEDVKYLEEPYQPCAINGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEH1</accession>
    <name>A0A2R6NEH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001323">
        <property type="protein sequence ID" value="PSR70774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEH1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="17100" checksum="B99D7FACDA7077D7" modified="2018-06-20" version="1">MITPTAISSNHTSVIVLGSKTDERRYSASAAKIGFIKALSSRNDDIVAYNAVIRLIVVAQSQEVARLKAMKELAGKHTMADTDLQQISGQVLFENAVLQHGQASIDVQNLAKRKDPTSMENSGSGSPDVPLSITSDVLAIRPNLLELLLTATEENGFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF20</accession>
    <name>A0A2R6NF20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001299">
        <property type="protein sequence ID" value="PSR70984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF20"/>
    <dbReference type="OrthoDB" id="2758740at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="609" mass="67162" checksum="0E30CE94440E8D83" modified="2018-06-20" version="1">MATKYNNTHVGAKPVDSVEETPEDIDELSEDQYGDVETPSEPIELSSDDGHPGNDYGELFNWSPSSDTELNAEIAAAIEAAEASRTPPKLVIRLPGASQRRSQRSASVSSDEEPISTQASRFTASTSRARCATTVVTTAASSVKKRSRETTLASQKRLKKDINHSPEPEVAPITKRSRGRPKKQDPPSIELTSFPAFIEVQEPPKLVRGRGRGAGKYETPHPITMGPVVVTFSMDYQSFLEALADEVHAGSPTNLVLASIQWRWVKLEGRNANAVSLPLTSEHGFQTMLAQIKVSALGVQGMAIVSMARPRIAAHSVPPWAQSLTSTPAPDCDTQEPQNLIAKKVSFDKQLEPIVEELNTMYHRGQCQRHPDISCYHFKEKDWHFELTENRFNVWASAILRKETDYGSPPLASKFFRHDQTIEAQNHRKHHVLPLPAAVAATAPSTPTPPAPYPSPYPTPYPSPYPSPYPSPYMYPIHSYGTPHSPHPWNTYGYPAAPPGQSPSNLPYEHLSLSTVGRKPPPSSSTLTDETPSSPILPPCDMDDFCVAMNLGDKEKMGLKNLGYQVGDKLSQIAEADWKAAGLLICDWNRIIRAEHKYRKEINKACRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF43</accession>
    <name>A0A2R6NF43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001304">
        <property type="protein sequence ID" value="PSR70899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF43"/>
    <dbReference type="OrthoDB" id="5427664at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="379" mass="42746" checksum="47C7DBC46B90E248" modified="2018-06-20" version="1">MLPIWRLTPGEYYESERARHALTRQDNQAPGRLSNLVASSVYSNVHKRDVKAAQKRAPHLKEQVILQWAWGIYLFVSPLYSQPECSGSTVLFMFLHSFDTSTINNLDKSYHFFVWPFWLLFCLFVTLFLVVFLALSSPNHANPNPSTSGYSGGTGISPATPVVIAWAHLAVNVVPSLKDKARQITFWVYIAAFCLWGLFIYSTEMQKRVNCVFSGENSFGGLGQITAIFVALAPLWSLSVALYKYPTLRRKQEHHRRDTSEDQESISSQEEHTALLYTRHHAPMPSEDTAYSHESIEMHRLVAIPQPSPSFPVRSRHRPSQNTPARESSTPHGSERKRGRLATRGTAAAAHVRQPSEVAAPHSDTGLMHWMDMSFPPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFA4</accession>
    <name>A0A2R6NFA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001335">
        <property type="protein sequence ID" value="PSR70682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFA4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="165" mass="18461" checksum="6061315296A5F8CE" modified="2018-06-20" version="1">MVSQWNHSLPVGRSTSTQNPESLWIERDLLYINGVPTDCACGTAVKSIQTAHILIIQGEVIQLRIGFDPNGTRGPDQGYESSLEVQPTNKSERYDLLTPSVKTNEGELGRVPCYAMDNDKYVIEEMIWELYLLSNGNNFGMVHCPADDRTIRLYDDAILVAIVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFY6</accession>
    <name>A0A2R6NFY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFY6"/>
    <dbReference type="OrthoDB" id="3349961at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="16608" checksum="722684778B158DFB" modified="2018-06-20" version="1">MIFGKHFHRKEAPWEVVDCHAVTPISMWDDIEELEVVRMHDADMSFKIEHDIQRSTDLQKVLQVARYHLMEQAFQHNFNVLLVEGWRLTLMRKGKKYRVEVVYTGRPAYAMGKDTRVPAPPFLCFLEQCQRELHQLLPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGZ6</accession>
    <name>A0A2R6NGZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGZ6"/>
    <dbReference type="OrthoDB" id="3268823at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="685" mass="71207" checksum="E72AF707D9C51C59" modified="2018-06-20" version="1">MSGIPPQLDAEPGTPAREWAAKTASALDPSLTKTTTFTTTSKPAGTVMTEPVGTSMNPTTRQMFEEKNMRPGTIAPETFSMSNTIPPSVTTPGYEVPGAYPSNEDTTAHGESITNTAVNTAQRVAESVSNGASTYLPAAAHTAAQYLPKSFVDSVSAYMPGASNPQDEAVMASEHDKLHKKSLPSTELTGQRNREYTEGVGSLPGPIVESEVAKLPDERNATIPTAEGATAIAKDTVHGAAQTAYSAKDRVAQAAPFAFGAAGGANTSLPTSEKLGQQPYEHSGGVGALPGNLNEPAVATLPDQNPRGSTAATSASVGTHGRTFDTTTLPSQEHDIGVGGSVSGGVGALPGKAGEEGVAILPDERGGSGKWEHDDSRNPGMNQRKIEARPLADPKIGETAVLADRARAAGAEKHEAMGNTSSKDTAASVDAPTTVKTDTGPSTGATTPKESAGTWDTHVHSKATQRTGDAAGAAAIGSAVGKRAMEKKDEKQDQKQAQKQEQKQEKPKAENQGKPNEMEDGRGDDDGAHDEKQADLRHVTLEPRAHVLGTEGATWQGVDVGSDAYKRGKNVDIGGGYDTDYHPSQLHPANADYSKEQAQSDDNNEEPLTGAKHADSKLASHAAGTGSATDHDDDSSSHGQKTKKAGFMQKMKGEAMVLLGKAEGKKGHDKVEEGQRIKSGQAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH56</accession>
    <name>A0A2R6NH56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH56"/>
    <dbReference type="STRING" id="98765.A0A2R6NH56"/>
    <dbReference type="OrthoDB" id="10054765at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="205" mass="22030" checksum="8D19E5412DC6FBA0" modified="2018-06-20" version="1">MEEIQDHPLLSTPSSSTYETIQGLNQDDLAISGTLVLSGLPDDHVPAFSPVTSVPSSLHRADLLLLSTLKSSLSTLRTLPVSPYPVQAGTPVRAHFVVHQEPEEEGWRPWVGGTWSKWVKGTVLGYRDMAGQEAKPGTYDALSHLLFKPLPTPGSSGGPIVDEETGAIVGVIVGTRMDSQIDGLRGWGRPAETIFELLGLNLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHA4</accession>
    <name>A0A2R6NHA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001244">
        <property type="protein sequence ID" value="PSR71765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHA4"/>
    <dbReference type="STRING" id="98765.A0A2R6NHA4"/>
    <dbReference type="OrthoDB" id="2802356at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="459" mass="46715" checksum="40EDFAB320D49642" modified="2018-06-20" version="1">MSAYDYYRANYQGWGSTQLSFKTPPPPSFQPRSTWSGWDYYRAQAVNPDHNLYYSIMNRVGGLGASSSGGPGQTEARSWHRRVYSGLVSLAHILPADIGAAGAYEAYRMWKYHYAPLFETLGGVPEREREALIGMAIGEASRLWQYSGRPMDTYGLRDCLESAAMIASRIAFNVIDRRSTGMGSGMGSSYERDYGSTRHRRLSSVSTASRPIVIQQPGGSPYLGGASSAYGGGSGFGGAGIPIPAGGGSPYAGGMGLGGGSHYGAGGSPYGGGGIPIAGSGAGHSPYGGGGGLPGSYGNNGGGIAGSYGNTGGGLPGYTSSGGGYPGGGGGGYAGSHGEHGYAGGAQMMGSTQPWQAPGSGMQGRTSPYMGGGGIGQSGYAGSGYAEPSRGYGGASAYGQSQPYGGGGASIIANGQTIPAPPGSTIIIKGRSRRSSSSGYRHHRSRSQEPMRTPMGYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHF9</accession>
    <name>A0A2R6NHF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHF9"/>
    <dbReference type="STRING" id="98765.A0A2R6NHF9"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="595"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117836" checksum="114F504AB4BC94FA" modified="2018-06-20" version="1">MASITRHLNGLIGSLDESSEGDRRALEEWTKLPSNGLHATENTTEEEELASDGEWNSVLDIYRNLAVVHNDQPSALLSKLLLKPDSEPLLASLRSLLSSTRPDDAISGELVDTLGFEDMDLVMEILGDRTNVAREVESSQSIIRIVGLSATLPNYIDVADFLRVNRHKGLFYFDSSFRPVPLEQHFIGVRGKPNGPRSRKNMDRVTFDKVAELVHEGHQVMVFVHARKETVKTALALKEAALAEGSLDEFSCEEHPSFSLFRRDIGQSRNKEMKQLFDNGFGIHHAGMLRSDRNMMERMFEARAIKSGTDDSKGKVNILLQAYISKYRPEDFALVSDQAYAAQNGGRIIRALLEIAISRKWASASAVLMGMSKAIEKRLWPFDQPLKQFELKADIFYNLERFADDYTIAELAALSTTELGELVHLNERHGSAIKDAAKQFPTVRLSYDLRPLGSDVLKITVHVTRMFNWSSRVHGTAEPFWLWIEDHDSITILQLSHLVFRQTTTALNADFVISVPNGQPPPFVTIRFVSDRWMGAEDELAVPFDDLIMPAPTDCHSPRLDIPFLSLNALQDSVLQDILSLKIRNLNAIQSQTFWSLTNTRFHSLLCAPTGCGKSLAGQLTAWRTLRDSADDSWVLIVAPRRSIVTEILAELRPVCKVMGFALDLITSEKTFTPSNERAIRLITASNLLSLMSRGTQHKASFSGLRMVLCENLELLDPAYELGISTLMHETQQFPVRYVGLSNSLNDPADLAAWLNVDPSALHSFRPNERDQALTVSTTTFTIPQSAALFKAMAKPAHAAIQSVIRGVYGEPAIVFVPSRSQCRSVALDLITQCALEVETGKGYRLDEIAPDALERSLARLQDRSLVDFITGGVGFFHEGISKSDRTVMLELYAEGIVRVLIVPHDSCWSLPVRAAVVVVMGTQYFHVNGNEWQLRDYSLEELVRMQGRAVRHNNTGHFHLFCQAEGKDTFTRFLNDGLPLESKLLEGDELRTWYQGQRNRGSIRSKQDGVDALSFTFLARRLETNPVYYDMTTESRSKKLSRIVDSLEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHG0</accession>
    <name>A0A2R6NHG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v12328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHG0"/>
    <dbReference type="STRING" id="98765.A0A2R6NHG0"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8 9" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="212"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="355"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR71827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="490" mass="53912" checksum="7E47D8D1F0003ED6" modified="2018-06-20" version="1">MSTFDSLVADLIRDAHRVQPKDALQFCANWFQSRLEEQRTRTRDALSNRMTPVRDLPTDHYSDVPLSPTASAVGASGYSQPFSKQRSSLRNSMSNDSPFGTLNVPGNALLNDNSTSHQHAMSPPTFKLDGDDMSPSSPLSPANPFASFANGSISPSPGDYLHPPTSTILARRTSVSAESIAVDSNVDEPPSVYPKTADQLRRIRASIANNFIFRDLDEEQEAGVLNAMREIHVGSNEVVIRQGDVGELFYVVEAGLLHCYIRQEPLPPSWSTGSKETFVQPGYHPEFGRKVAECSEGNSFGELALMYGHPRAATVLSIEPSTLWSLDRITFRTIILKAAYRRRTMYEQFLSSVPLLTSLGPEERSKVADSLTSKIYSDGEPVVRQGEMGHTFFFVEEGEAIVTKTQSTEGGEVAEVPVGHLRKGDYFGELSLLRLEPRAATVSAIMRSDSTIPKLKVAALDAHAFTRLLGPLREIMERNAGQAYGTRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHS0</accession>
    <name>A0A2R6NHS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHS0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5727" checksum="DD9B88AEF64FE3FF" modified="2018-06-20" version="1">MPKGTQKEPWSVHLNPNGRIPVLVDRSGRAAEAAGFAGFQTAMILLHLELHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHU0</accession>
    <name>A0A2R6NHU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHU0"/>
    <dbReference type="STRING" id="98765.A0A2R6NHU0"/>
    <dbReference type="OrthoDB" id="3237025at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10038" checksum="E256D2648201A120" modified="2018-06-20" version="1">MSESLRSGSSWHSHDVAETDKESSPKRLSRVKEATNQGDSDFEAEIYAASPKLRGRTLTAALAFVAGTGFTLFGYDQGVMSALLTAPQVRCGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHX0</accession>
    <name>A0A2R6NHX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHX0"/>
    <dbReference type="OrthoDB" id="3266941at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015345624" evidence="2">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="256" mass="26799" checksum="7AEEB2477FB085BD" modified="2018-06-20" version="1">MLISFASLLLAFGPPVVLSHFKSITFSAVQQCGNFSVNFSGGQVPSSLPLTLTVVPFNSTPIFIEIPISSWNTTTLTGASVTFLPFPADIEFVASLDDANGVGTGPVSDVIRVDPSDNSSCIPQVSSTPASRYTVDTPFAQCAPVDVRYDTNIVDTPPTIRAFVPRNASFFLNQTDVSNTAGQASFTMDALQGQQVVLLLSDDAGFKGTTDLLAVGGNSSSPTSCLPTPMSRQNNHHGHSSAPTPTPTPSKGSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI50</accession>
    <name>A0A2R6NI50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI50"/>
    <dbReference type="STRING" id="98765.A0A2R6NI50"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="298" mass="31089" checksum="C99BF0EC5CCE0EF7" modified="2018-06-20" version="1">MSSSSFLLENLFDLKDRIALVTGGGTGIGWMIAQGLAANGAKVYITGRRKEVLEKTAASFDGKGSVIPMVMDATNRESIASAQKTIQTQEGRLHILVNNAGQGGPVSPFFNDTSAPEHQSPGALGGALFTNESFEEWADVYTINSSSIFFVTTAFLGLLAKGSEDRAGYTSCVVNNSSISGHMKLAQNHFGYNSSKAAAAHLTKMLSTEFALKKIPVRVCGVAPGVYESEMTAKRLAQGGDAVNAVGLGVLPVPAGRAGTPEEIAGTVIYLVSPAGCYTNGQEIMVDGGYLAVNPSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIK8</accession>
    <name>A0A2R6NIK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001206">
        <property type="protein sequence ID" value="PSR72190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIK8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="6081" checksum="B3F2C98329920DE4" modified="2018-06-20" version="1">MYKSQILSYPSDKMIFECAFDHLMQDIRQQKLMDISTWEPNGKRLMTLGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIS3</accession>
    <name>A0A2R6NIS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001198">
        <property type="protein sequence ID" value="PSR72233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIS3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17291" checksum="0D6251CA3E251F1E" modified="2018-06-20" version="1">MAVAGPTDIPPELVFHVVECLLPVKFDAWLPRCDRLTLARCSLVCTYWSTLFRSVLFKRLELWAERDVYTLQAFIDSPTKNLIHRLVLHPTPTRWIPLIPALIQDLPNCHRVEMVLEKHFLGHTAAPFFRAPRFSLSSPKYAHCPSRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJA2</accession>
    <name>A0A2R6NJA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJA2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8213" checksum="135E0D0E71661A84" modified="2018-06-20" version="1">MASFSRWSAPGFRVPTMSEIAGNMGEVLEHDAVHDEYITAGTSTPLELTTYNTGADPEYVRDAVASQDIALRYSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJQ1</accession>
    <name>A0A2R6NJQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001152">
        <property type="protein sequence ID" value="PSR72607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJQ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NJQ1"/>
    <dbReference type="OrthoDB" id="2641762at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="35885" checksum="8F3079E26F179FA9" modified="2018-06-20" version="1">MSDPAFKPDEDANTIFQEDTWLQGSLIMCIAYGAVATLSIQCFFMLIRGTRRSKWLRDIPLLAFVISIFMLSTIFIGTAMQFTQQAFVDQRNFPGGPAAYEVVEFSLPIDSVANCWRCTVIYKNSSLPAWVSVGLASIFWLVEFILGSLFLGQIMSTSPWGAVNFTLGFWCFSLALNIIATFLIVGRLLFYRRRLAHIVGKGHGEQFTGLIAMVVESELMYTAFLILFIVPFILNHPLENVFIQGIALVQATAALMIVYRVAGGQGWTAETYVQVTTRMGSNPQLAGVSSTLRGPSAGAVAEAEGKTSTSGSGISANRDMYVSKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK00</accession>
    <name>A0A2R6NK00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK00"/>
    <dbReference type="STRING" id="98765.A0A2R6NK00"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328">
        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="27905" checksum="9D108F265A756068" modified="2018-06-20" version="1">MAQPYLHPLQVNPRTGEPFLRLPSPLDNFIITPPRLSDAPALMETLNDPRVYKTLESPPFPYLPTHAESWLDMITKESDAALEEAKKAYKEGASEPLGHVETCPVRYIREIKEDGSDVFVGEIAPHRCQYLDVKDQWEREELVRTNLRYAVGDPAIVWCFGDFVAGPYHGRGIMSGALKTIMAQWLIPRMGARLIRVEAFIGNVGSVRVFEKNGFVMEKTVQYEKVTNCGVTRLGLHVLLWHAEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLB9</accession>
    <name>A0A2R6NLB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001107">
        <property type="protein sequence ID" value="PSR73101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLB9"/>
    <dbReference type="OrthoDB" id="3306680at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="212" mass="23856" checksum="159E4A09107933C8" modified="2018-06-20" version="1">MMQFTAARKECMLSMDCLTSKDLTAALHFQKSDDDGGKDTFSCVKVLHKPTPINGVQRDCLPAEFFVIGQVVEEEVQFLQEMQQGGKTITRASFWLEQRHDPTSQVQWERTLIALHHIVGRTTVDVDTSTLFSVNAKTGAMRLRVHASESHTSRELSGYTMFDGEGDSFRLTCESSLPSSVAVRAVFNIEYKKRARDGSHFMHAPLTYLSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMT9</accession>
    <name>A0A2R6NMT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001068">
        <property type="protein sequence ID" value="PSR73707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NMT9"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="6">
        <location>
            <begin position="64"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="342" mass="37734" checksum="BA685C161F05507D" modified="2018-06-20" version="1">MPKVASSLPLSGLFALAKPSGPISMSLVNQMKPLIMNTRLFVEASKLDNSQTQQKQKKGRFSRNAVKIGQGGTLDPLADGVLVIGIGKGTKHLTSLLDCVKEYRTTALLGCETDTYDSEGSQVRVAPWKHVTREQVENALEQFRGEIKQAPPIFSALKMDGKHLYDYARQGIPLPRPIEKRPVTVHSLEIIEWKGSDHDFRFPEKKFTEEQKQAVARAMNGIKDQVRVDDEPETEVDNAPNVAPTAFVLKMKVSGGTYVRSIVHDLGHAVGSAAHVVTLTRSRQGRFALEPTGKDDIGCVAWEVFAKAAENPGEPDADGWLEWERKVLDKLEIVEGKEQSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNP8</accession>
    <name>A0A2R6NNP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v10139</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="MLYV02001021">
        <property type="protein sequence ID" value="PSR74067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNP8"/>
    <dbReference type="STRING" id="98765.A0A2R6NNP8"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR74067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="263" mass="28508" checksum="8F2D8A2D80630F40" modified="2018-06-20" version="1">MAPVAVSPLLPTMSSPIPNKPRTTNGTIDVPPVPPSPSSSARPQEVLNAPPRTQFSFDSMEDALAGFGRGEFLVVADDEDRENEGDLIIAASEVSTEKMAWMIKHTSGYICISLPAERLQELDIPMMVAQNEDPHRTAYTVTVDYKHGTTTGISAHDRALTARALASSHTSPSSLSRPGHMVPLRARPGGVLTRPGHTESGVDLCALTGLPQAGVLCELVNDDELGTMMRRDALRAFADRWGLKMISVEMIARWRRKLESTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNZ5</accession>
    <name>A0A2R6NNZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNZ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NNZ5"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="2">
        <location>
            <begin position="79"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="312" mass="34984" checksum="3709853726E88183" modified="2018-06-20" version="1">MSRKDMPRAFVVGSPPMFRGTTQPGRDIERQILKHFPGVALFIEKPIATGPSGEIEEAFKVAKHISDSGAVCSVGYMLRYLKAVQMMKQILEENNLTVMATVARYATAYEAIAKPDWWDKARSAGPIVEQGTHFCDLSRYFGGDVDISTVSAHSLEWYENAGQLSKMQVDETAIPPENRIPRVTAATWKYESGAVGSFTHLVALQGHDYSCELEVYADGYQLKLVNPYVQPVLYIRRPGSDLEETHRFADDDPFFSEISVLIDNIEDIEEDPETAQILCTFEDACKSYQLTWAIREASERSRNIKKDTVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRD2</accession>
    <name>A0A2R6NRD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v9231</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000910">
        <property type="protein sequence ID" value="PSR75265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRD2"/>
    <dbReference type="STRING" id="98765.A0A2R6NRD2"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR75265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="17578" checksum="74CFF442A25C8232" modified="2018-06-20" version="1">MEISKDEVSNPIKHSVSGKKGRLQYVRNCFPHHGYMWNYGSLPQTWEDDSTPSGAICTSEPGVTGDLLDVCEISNSPAYIGQIKCVKVLGIMGVLQPPSLSSYEPIIQDSSVASELPISFKIIAIDITDDLAEKLHNIDDVEKWCPGIMSGTKEWFRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRI6</accession>
    <name>A0A2R6NRI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Component of the lid subcomplex of the 19S RC.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRI6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRI6"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="385" mass="43213" checksum="055E51C7C044647B" modified="2018-06-20" version="1">MSEEVVLPIPNLELAQHYFVLSSPQLSQLHENARKELIAGIQADEMAPYYRLVISTGALPSDQTILESLENANKEELAKLDERVAEAEKQEGESDIADALKARANYLTKIGDKDKSIEAQKVALEKTAGAGSRIDVVLTLIRIGFFFGDNTLVTENMAKAEALVEEGGDWDRRNRLKVYRGLHLLSVRQFKRGGELLLDALSTFTATELISYNDFVVLTVIGNVLTLDRPDLKKKLIGAPEVNQVLPEMPILADLIKSLYDSHYDKFFVALATLEQTLLLPSRLLSPHARFYVREMRILAYNQLLQSYRSLTLDSMARSFGVSIEFIDNELSRFIASGRLHCTIDKVNGLVETNRPAVKQSQYETVVRQGDILLNSVQRLSKVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSR9</accession>
    <name>A0A2R6NSR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000868">
        <property type="protein sequence ID" value="PSR75994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSR9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="46097" checksum="3CF8EDD88ACEDFBA" modified="2018-06-20" version="1">MASTLPSELLDRIVDFLALDIGVFDSYGFQEMKRYKHTLGACMLTCRYWWLRCRPHLFEYTILRSPDDLDGLLSLLSSSDSIISQSVRVLWVYEYKRNIAPWSHRILLSLLPRLDRLETIQYQNHPKARTAVPPTVSRGLSALYSNVRNVTSLTLSQQDFISFSEFLHIIGAIRSLKALTCDHLSWKKTPANPSMICGAWELERISASLCKEHWPFIWLLIARPKGKAASAMITRAVIGPEDLLTVGELARSFNSHIYMELPGSIIKTTLEFSLFQSAPSPSNSSDPPLSFSSFQNFVVQMDPPVSQLEWDEAIKQEILSYDWKRIDSLLQLLVRPGLSSVTIRINLSVFINDTKPLMEALTQEIQACMPHMQRENGLELIFPKRQAPQIDETPAIHVRTQAIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSS8</accession>
    <name>A0A2R6NSS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000871">
        <property type="protein sequence ID" value="PSR75954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSS8"/>
    <dbReference type="OrthoDB" id="2802668at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="385" mass="42844" checksum="48E62C5E692483B2" modified="2018-06-20" version="1">MPRESTLPSELLYEIVGLIFGEYLDDVIAGPHRFPGPTPLEIVSVKLLTGTGLQEPIPPPANQNTEDLALSLPNPVIPLLNTSFQLREVTLKVMSDALGIAIHNEGVGRLVLKPWPRIQLIRMTYMNPLEYQPDRGSSPLLTTYHLLALAHIHYSTATLLDARPDLQELMDAVESDQQPEQRLGYGQLQSIFDIVIALPFTIKQGVLKNAVIFRVADMVCRIPAFIQFKDVLSCALTVYDTLKDIDDVIVRATEVGYQIDLMESRYAATVDALHRTLKQYCRADMQRNRLRDKYSVWLMTDTISPNLGIEFLDIAKARGLMQNIVDYSERPGTEYPKCRQVALAILGSLVIFDAAAAAAKPREDFAPPVTADSVDSFNIGKLNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NST8</accession>
    <name>A0A2R6NST8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NST8"/>
    <dbReference type="STRING" id="98765.A0A2R6NST8"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015303238" evidence="3">
        <location>
            <begin position="21"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="622" mass="66365" checksum="14730F52F6D5975C" modified="2018-06-20" version="1">MFSFISIAALALSAVASVHGAAIPRTNVPSTYDAAVLEPYSQYNTRYMALDCEDKHNTQFFTDCCHPMKSNETLAKNRLPYCNPATASLSSSAALPTETDNSDDECDDDDEPSSSVAPSVTATPTVVPSAVTTSRISSSAPSSVKPSSVKASSTPVAPVNVAPAPSKAAPTPSPSPSQAATGIDSLIHTGHATWFYQHDTAGACGNVHADTDKVVALDSALYGNLGAVSQYCGKSLVITNTDTGKSVTAIVADACPTCDAAGSIDLSQGAFEALDTLENGQFDALPVDPTRHLKAILLPGHPKCCSFPIFRPLPPLSYIVHGKQVTWEKANALQPETYAHLLPGATAVVHTLGTLLEDARYKAALKDGNLPALVGAFMSGFAGGTRNPLEERRTDGSYEELNRDAGMCPFAFITCNYRENSLLTHRSGAALRVCEAFVSSTSEVRLDHPRPFVYVSAEDIFRPFISARYIETKREAEIEIESMMASKPDFRGVYIRPSLIYHPHFRPLTSPVAALLDLSATVHSRAPKGLPTPSGILHSLASAVTRTSSSHSLISSSPLHSMADALTIPPIHVDHVAEAICIAADSARDDVKGVVDVQEMRRLIGWTQKGRSNERSRLEQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT74</accession>
    <name>A0A2R6NT74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT74"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015349412" description="Peptidase S28" evidence="6">
        <location>
            <begin position="22"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR76204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="57650" checksum="F3978EE01354A4C8" modified="2018-06-20" version="1">MWSFAWKITSFILPLITLTTARLFDGRLHSNSPSLHKVASARFLDGKLHANSTSPSLHKVTSARLLDGRLHANSPPLHKVPVFATNDRRPTDVTGASLPPLSTVYTFDQPIDHTNASSATFQQRYWTTWEWYETGGPIILFTPGEENAEPYIGYLTNETINGQIAQQEHGATIVLEHRYYGLSNPFSDLSVQSLQYHTIQQAIDDLEYFATNVQLPMPGGDDVSIATTPWVLVGGSYSGALTSWTMVNKAGLFSAGYASSAVVQATVDFWAYFEPIRQFMPANCSADVEAVIGHIDSVFTNGSTSDIDQLKALFGWQNLTHLDDAAGSLRNNLWDWQSLDVDTGPGGQFFKFCDALEVQNGTSAPASGWGLTIALQAWASYWTTTYYPQSKCNELGFYQEGTPSEDQPTLVSRLIQPAYDERQCTLRFPGAWSSPPTPSADSVNTAYDGWNVAIDRLFFANGQRDPWRGATVSANATDLQSTTQLAMGDGFHCSDLLTSNGVVDNTVLAVQAQGLASINAWLANAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTQ1</accession>
    <name>A0A2R6NTQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTQ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NTQ1"/>
    <dbReference type="OrthoDB" id="2793851at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="102" mass="11036" checksum="40B238CC76160DD6" modified="2018-06-20" version="1">MCELPAITERAAEADGHIFICTDANWSGSCTDYGFTAGVCSNFPQGFQDDISSLGPDAGWFCNVYIDYNCNNDQSSLRVDNPGIASLGWGNDAFSSLQCFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTV4</accession>
    <name>A0A2R6NTV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000838">
        <property type="protein sequence ID" value="PSR76586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTV4"/>
    <dbReference type="STRING" id="98765.A0A2R6NTV4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="16882" checksum="3B3E890A376BA624" modified="2018-06-20" version="1">MALFVIGVAGFGRRIFWKEDELVPPGHKVTFKVAYLFLQMREKITHHTFQGALHTVAKEVFTKLVVPDWVLKLGLTESHRQTTLAFDELHMYLVEMIRARKESEKKEERYDLFSSLLDANEEEEDGQVKLQDSELIGMYYDDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU05</accession>
    <name>A0A2R6NU05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v8258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU05"/>
    <dbReference type="STRING" id="98765.A0A2R6NU05"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR76661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="34431" checksum="02154F5FFE2DB388" modified="2018-06-20" version="1">MATTITLKRTGDKVPRSECAEIVYKALKAGYRLLDGAGDYGNEIEAGEGLARAIKEGIVKREDVFITSKLWNTFHEKQRAKDIARHQLELWGIDYFDLYLIHFPISLEYVEPSAKYPPEWWGLDGAPHPTKVPIQETWTAMEELADEGIAKNIGVSNFQGSILIDLFRYARIEPQVLQVELHPYLTQESLVALSKTLGIAVTAYSSLGPQSWLELGMHTKTPGLLTHDTVTSIAKTHSRSSAQILLRWAVQQGLAVIPKSSNHDRLLQNLQVTDFSLSEEETKALSALNINYRLNDPQTIHPALGIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU98</accession>
    <name>A0A2R6NU98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000836">
        <property type="protein sequence ID" value="PSR76749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU98"/>
    <dbReference type="OrthoDB" id="3223416at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015358211" description="Cupin type-1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="18928" checksum="F1B96FB8BC2E2C8D" modified="2018-06-20" version="1">MLAPFVVLAAAVVSACALSTTGIISNHTAPPASQNFFEATAIVPDVHGNSALECWRLSTAFTASTGAGTVGASTMNINDLANATYTVLPPRFEGGVHNSPHPQLVVFLSGVVHVTLPHGTGDAWVVGGIDGLIFAVDSVGTGHNTSYPSNSETRALQIPFTDGVIPPHTVVNSGACLINSQIVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV02</accession>
    <name>A0A2R6NV02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-CoA oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000810">
        <property type="protein sequence ID" value="PSR77170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV02"/>
    <dbReference type="STRING" id="98765.A0A2R6NV02"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64876" checksum="4B153625FC364D1C" modified="2018-06-20" version="1">MNNELFNHPAFKTRSELLQVDDRVTLAYDRAKAVFKAWSTSYAAPCSQYSCVLIMVSPDLNVEEIVTCSKRFWEMQADPIIVLDVGCSNILGCHINLFLGTLGALLPRRPDLGPVISQALRCEFFGNFLLSEVAHGLDIMNLETTATRVQDGFILHTPHPGAAKFMPPTTPIRGYPKMAIVLAKLIVDGKEHGTHPFLVATSDGRRMCAGIASIRLPPRSGSSPLDYAITTFDQVHLPPSAFLGFSMENPANRQTLLHRYIWRIGVGSMAIPMNSVTATSFIATIGADYSFRRHVQGKGSEKVPIISFRTQQLPILHATAIAYVLEAWRPHAIEQFMEQGIDPRVRHGLAVVFKTTVCRLVTMCAQDVGERLGAQGTFVHNLISQMEMDNRGISIAEGDILVLCIRLFSELLLERYSLPQPSRQDTLLARHSAHMFSACSSLLSSFPRGHKDERFNSIILPQCEAAISALGQAMAYSFALDDGVPKPLLDLFECAMIKQDSAWYVEHVGVTGDIRRDWEDLAAKATLPDLRDYVDALGVRAWVTAPIISDEAWKDWLPLLKVHRSPSRIEQNEAEDAIRLMAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV37</accession>
    <name>A0A2R6NV37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV37"/>
    <dbReference type="STRING" id="98765.A0A2R6NV37"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="769"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="948" mass="107098" checksum="C55CE29DF6AEF623" modified="2018-06-20" version="1">MSEKQVGGGPKSGREGLGRRRRNAGPRSPEAIDTGSNKTALSSCNKLLKKQPQNDLVKALKALALSRLQKFEEAGVLCEEILASKPTDESTLGAMSHTLRGLGRHMDIITMYESAWKQQPGNEELAIQTFSANARTGNWKLAQQVAIRLHKQFKEDRYLYWNVFCAVLQASDPTTLPPLRPVLYKLAHRLITTSEIPSFYSPDRFYVHILILKELGLYEEAAALLESEKGKDICGRSLICDELRREIWVLKGSVKEEGQRAQDRILKKDDRNWLEFLSVLNATFHDINSTEEPTEETRAACQDQINKTQVFFAEIADRDGARDRSGPLALLELELRARKNALSIDPSALYTLTESYFQQYGDKPCCYEDLLPYVADFNVEDLSRWTSFLQIYTLSDTLDDLRRTTNALKLIRYSLTPAELTPESENARAAQYMDIYYNGLKHGKDLADTELQHADDLLALAAHAFVNSWKISGDQANLYNAITVLEFGLTRSKQAYQFRLMLVRIYHILGAPSLALEHYRLLNVKQVQTDTLSHFILTRASTFALSSLGDLTYSTECIEASQIYQSNSLDTAEFVIRAFLTEKYSQIADFVTLEDRLDNSLQRDLMKMEHVRMRVAHEPISAELVDVELVELKFIFDRLHYDNRDFDILPNYQPRSQPTFNEQTKMFGKIPGKGWLWMFLKVYILACRHASDMDDTAEEKLVLGDRPKTNPNIEAVKLPLQERLAMRPQEELDELTSDELALVNFETSVAEWLGPHHDFIRPLPSVEHTNGTKQTENTHTTNGTNGHSKKLDEQPTSKEPPEIATQFFDEMKQRFDTALQASSLPPELLHIVTLTQEAFLLFAIETTRFKSSAVVKAHKLGAVVQSIKDIRSKAAAVLTAMSVELDKLAAADGSPERSQVFIDACQPLVASEITEEFVSEVAKKVVDARKQIVEGIAKGVAKVCKNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV58</accession>
    <name>A0A2R6NV58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000795">
        <property type="protein sequence ID" value="PSR77395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV58"/>
    <dbReference type="OrthoDB" id="2839137at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="12238" checksum="9C441CFE63476B4D" modified="2018-06-20" version="1">MVTTIASSSLNLTTIPPVAGSAICRFESAQMKGKPIIVIRLVKILEPLVVSPETPNFPPLREGDLLRGKKRTWHYKTADGEWTSTRNDCRRGLRYLKEYPEASFDYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVA9</accession>
    <name>A0A2R6NVA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ASX DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000814">
        <property type="protein sequence ID" value="PSR77077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVA9"/>
    <dbReference type="STRING" id="98765.A0A2R6NVA9"/>
    <dbReference type="OrthoDB" id="2289918at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASX DEUBAD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR77077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="201" mass="22187" checksum="619CBEB342AF3E52" modified="2018-06-20" version="1">MSDTEGTQERPRRSARTPNKSPATVVNGPSSKPAARRKARDPGAQLDHLLTNSKSQLTKVDISDVLNFDNFLELSVESQELLCSLFPATAFSTFQPTIDPTHPANMGKGGPESSSQESPPKPLSATFDRSPTTLDPVVFTSPFFLSAARTFQDHIYSGWLASKAKDLVKQYEQGVGEGSLHAEWKDEEWERNRNPLKRQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWN0</accession>
    <name>A0A2R6NWN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000741">
        <property type="protein sequence ID" value="PSR78441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWN0"/>
    <dbReference type="STRING" id="98765.A0A2R6NWN0"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="660" mass="73035" checksum="F97981DD751676F0" modified="2018-06-20" version="1" fragment="single">PARPRVVKETREAILRQLILATYASAEKPVKEAMTASGVKDSFAISIINDLIAAGKVLRKSTPTRKALSAEVVNQLLTEEIKKYKDSPVMNPLLEMPGYASRASAHPSPRDREVLLGSNHVGEKNKHLPMFQSRLNSVNQDSLNVPNILANYMCRYRGGLIGKHFKTIRQVMVFAIAGLVSEDLKNTWLAIGRLTVLIWQTDIRDVTQYLDLLLSIQDVQDFAATLSPGILLTKIEFHVISHLIEHVRRFGPAVLFSTERYEAFNRVFRLCSIHSNRQAPSRDIANTFANLDRCRHIVMGGQWYDRKCQKWVSAGKAVMLHIQNDVRDAHLLGVLLNKLKAPGTMALSTIARDEDSGKRRARAAPLTWNQTQACSLLPALPSIPGRWFPAVSVVTASQDVAYIGNEVLVRSEQGEFSPLRFASIIELLSPASSDNGLDDSHGLPALVLVQYSSLAADLHAHLKMPIISRIRDMRLVNPEVVSQERQASGRTWLVIGHNPSSQYVINVNALHNNLYVRQALPASLQERPQFFDNRTELYLAAAASLRDQRLQKKLAREAMARKKAEDARFAHNIGSGDSSLTLLEHADSETEVDGVPELSMQTVSLPDGSSLPTPRGLRERRAGSNRGRGELTRGSSRIAGGAAGATTGRKRKAGVSIRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX24</accession>
    <name>A0A2R6NX24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000716">
        <property type="protein sequence ID" value="PSR78908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX24"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="10371" checksum="D5F523238A7E7D62" modified="2018-06-20" version="1">MIPTGPLLLVDCSASGVGAIGTAVAVTTVMAEEDGLKVETVVVTKSDVGDGDGEKAVVGTKVTIGTPDEGAEEEPWDSAEVLRAPEDMELSGMLRWAARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX40</accession>
    <name>A0A2R6NX40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR78989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX40"/>
    <dbReference type="STRING" id="98765.A0A2R6NX40"/>
    <dbReference type="OrthoDB" id="2670057at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="466" mass="50838" checksum="F4DE4A3BEF8E2A35" modified="2018-06-20" version="1">MHVHSRHAKRQAPSLGGTSFIATTTAPLSELILATDSAEVPITSAPPIGTVTSIIVTPSSSTVDSSPASSAGSAAVKNSSIGMSTVVGACVGAFAGLALVVCIFIWWSRHPATKTRGSPRSPISDHRNVRGEEDQERTRSGMWKKLDEDEWEGMPQPPPPTRQMSQQEVDEKNFSMFKKRSPSTRTTRTTKALEEHGFEMPPVEFSKYHPHLAEELSLQQPERHFGQRQDSGISWDGETVGDNSFLSLRSVRIESGAMSPTMAMAKMTPPPMSHLHRWESAEVITLEDPIDTPEAEYSNPFADVDVERRKSGSNPFFNAGDSHRPSRGRSRSNSHSASRNPSRTRAGTSRSHAISQSSQVDPFADIHMTAVTESEFSSHSHNDSIASGDSGNAFASEHAMKSLIAALDLTQDEVEERLRVVSMRPSTTSQYSSTLYGASSVKYDEEDDIATMKNFPIPPTSASYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXA6</accession>
    <name>A0A2R6NXA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXA6"/>
    <dbReference type="STRING" id="98765.A0A2R6NXA6"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="3">
        <location>
            <begin position="41"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="2">
        <location>
            <begin position="351"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR79042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="453" mass="50147" checksum="F6F88D5ECA4554DD" modified="2018-06-20" version="1">MAAFISHVTLDHLAVLNQPSDTDLSGRTPALKASLEAKSAGYDAICLPLTNDKWKARWRDMCLIPAGGTLDRVSLEHQAEDWRSAPGFMKDEVTITHLEEAEAVIAMVSDWLELDAADEWVRHDAEIALHQELAYASYLNIHTAILPPPRNRAHAASYARSINAALSLVPYMQLSVRLPIYDPSMIQIDATPPNSTSSTPSQPVALDDNHPSIATWEMWDVIRSICNYNPRLTLTLDLTPPLPSALEVLNQWIAEPTRYIFVPGSAFLANAKGYPVLPKGTQSFIRDIMKIQPSVILSGTDAGRHTKGGEAAYSQYIRHLEKTSPAVKAMQTSGTVENFAQGYQDYLQAPLQDRQNNEWGDKVQLLYGDMRTLPVPEPVDILVSELLGSFGDNELSPECLDGAMRFLKGKSDFISTRPAINHRISGRYLDTSIIYRVSCANLILEAIQRGPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY09</accession>
    <name>A0A2R6NY09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v7139</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY09"/>
    <dbReference type="STRING" id="98765.A0A2R6NY09"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015329380" description="non-specific serine/threonine protein kinase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="448"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR79168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="782" mass="86109" checksum="C3BF890B37891D10" modified="2018-06-20" version="1">MTVLRLYRLWSGLILPLGAANIPHAQLNVFPTQSSLVSLLGKLASCCKVKLLGCVPRGAHVWFLRLVLILPGLDASFADIIRDYIYKYSHGRTFKSQLTSTVFKGVATTTGFDTQLRQVHPLSTILGLDSDSTPQQAEVYASEIVVPIVEDDREDFNSALLAVTIPEDIALRYSSQSTSQSPALKTDEDEANTNKFNPAAFSSRTVVVVQDVFVEDDDYHKLLAATGSSPDNSNVLSHKEDESDWGSTSKGSHLSIGISRVPFIGHTDFGYYIPPVPTQGVWRYDFYSADMGYSADGQYLPSHTSLQYSETEADNPLAEESDSSMGSMSFNGVDGSPRSSDSSVSDYSSSDTGDEGMLTRIIMSQCDAGPLEVVPSDSVSDFDLDGPVRLTESDLAAHDHLEYDHAAPPSYSNSHLPPNYGGYEPVGLARVLHTSTKKDVLDNGRETFRIIGKIGHGGFGHVMLAETSDHKRVAIKVMHKPLLYQRSGMRQTAIKELDILKHITVDNKPFLAPLLCSWTDDENIYFVMVTAVDNLHQSGILHCDIKPENILMDADGQIALCDFGLSQFLEDIEKSGSLESGGTAGYSAPEAIRGEHIPGSEAAVDVWSLGMVLLELALGLRYSYFYGDVSSEANRRVMEEELPLRHVQDTVLRDMLRGMLNRDASERTTVKALKNHPYFAGISFDAVYHGYVRASTRSGPLYLDADQRYLHFSLRDLPVYKPAPCEGELSVFDVLDDQMEWNQVDIDNGTFDFSCNASLRGKLLHGQAAEDSESWVLYSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYF7</accession>
    <name>A0A2R6NYF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000659">
        <property type="protein sequence ID" value="PSR80265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYF7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="186" mass="20395" checksum="003B57762EB1C58D" modified="2018-06-20" version="1">MDETTSTVPSPSVLRLDDTDATAEDRQRLHIIIFRSDPSRNEFPISALPMPPVWRRDSIRLSTYCSGPDGTTTVGGTIVGRYVASESQWMRSLGKLVVLALREEDTLLAHRLLASAVGEENGMLSLSLVETGDYAGSRFSKPLWPQTVPRVSDPSHQINCTKGMFCCLNSLFTAIFLVLAIAPITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ59</accession>
    <name>A0A2R6NZ59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v6564</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000629">
        <property type="protein sequence ID" value="PSR81033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ59"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ59"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="153"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR81033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="447" mass="47846" checksum="DA6F7A6294AE107F" modified="2018-06-20" version="1">MVLPSTATTKLAFVALRSPGKWNAASRHRITLYRMASTSSFGLKDASLLRTQGFIDGKWVDAKEGGKISVTNPATAEELGTIPEMGLSETKEAIDAASKAFKTWSKTTAKERHDLLMKFYALMKEHDDDLSRLITLENGKPYTEAKGENAYSASFLELANRAGIPPGVINVVTTHGNIADVGRELCENPIVKKVSFTGSTPVAKMLYKYAAGTMKKMSIEAGGNAPFIVFDDADIGAAVEGALACKFRGSGQTCVCANRIYVHSSIYAEFASRLAEKVAAFKVGDGFEKSTTHGPLIHERAVEKVQKHVDDAVSRGAQLVHGGKRLDGAGSFFAPTILADVPADALVCQEETFGPLAALTKFETEEEVIKLANDTPVGLAGYFYSRDVGRVWRVAEALEVGMVGTNTGAISQAVIPFGGVKESGLGREGSHGIEEYMNTKYIAFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ81</accession>
    <name>A0A2R6NZ81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ81"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ81"/>
    <dbReference type="OrthoDB" id="2804698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="529" mass="56410" checksum="75B783654AC6A297" modified="2018-06-20" version="1">MLILGASRLCVPPSQLPSLSQPPPPWFAMSKSSKKVERGSRKVTEFFPRRSSAISSSQPPSSQPPSSPAQMTAPKLGATQRQAAASTGIPSKLEEEIIILSSDSGPITVSSASSHISISSDTHSVILVSDSSGPKENFAKRVIAKDSTPARQVMKSSVNAPAPTGAQTRVKRRTAAPVDPPLLTLPRAIPPRKRKLQWESSSDEGPAIPNPDKMKPSLACAPASRATLHSVSLPLAPMENTPSTPSKRYESGPSTPSKRARLSLREPPGLSNTSGNDADIEEIPSSQSDEHELTIPKTAKKDPAEVKERVDQWRRESSVVVSPNIRATSSPSEVAPLGSTLSSPLSSAVDIPYDSPEDSVLSSFPGIHDHMDVDEDIHQSPISPDLLIVENATGARTPKSEAEVSQQLYIRSSTPAFSSGSLSHAISPATSPQPHSQIRHPTEISPLDSITDALRPLTPPPMVALQELRATPVALDPKTKAEEMIAQIKAAAYAAVQSSPEEVPLDFNILDVASSSEDEDSDFHVTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZC9</accession>
    <name>A0A2R6NZC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZC9"/>
    <dbReference type="STRING" id="98765.A0A2R6NZC9"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="184" mass="20868" checksum="322AD014C3317AD2" modified="2018-06-20" version="1">MVRAVTTAKAKSNPRTTFLCLSNANSVFINTILKVISAKLYRCVFSDHTLQEKGLDTLFDEIITNPAEWDPSGLLKLRRRVDPSGPQHTCQVGCSPNMCKGEELEAFLARHQPAFDRVIYVGDGSNDYCPVLRLRSEDIVLCRTYRGLQRRIQKEGENDGLKCKVGYWGGAWEVEEYFAKFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P148</accession>
    <name>A0A2R6P148_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P148"/>
    <dbReference type="STRING" id="98765.A0A2R6P148"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="33859" checksum="07D472892EB3DC49" modified="2018-06-20" version="1">MSGDRLLVQIASYNTNLQAEHGLPQDLVDWLAPTLQVSTFLAHDPRAPDIVAVGFQELLPLHLGLSGLSSKVIESRNSLILSQIEEHAPNKERYTLIAKVVNVGVALLVYGLDDTVGRKVEDVQTQWTGCGPGYMGNKGGVGVRFRVPADDGGVGEVFTFVCAHLTAHAHKCARRIQDYHHIVGSLLFPPLPGTDSSTPTTIFSTSHLFFFGDLNFRVDFPPDSELSKLSRVEDAARILEQESVREDVKEYDQLLVERDQKGSVFVGLREGEFWKFKCSYKYKLGEVDRYEYGFSVHFSDESEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P154</accession>
    <name>A0A2R6P154_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P154"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11284" checksum="C6009D55B36981B4" modified="2018-06-20" version="1">MVEAIQRACTDAGNRRGDFIKEEDVMRYAASIPCTFHATLTSAQFSRGPANDKCIREDGIRGEETALAGRLRLPVVFCDPYCREYGSSSIIGSIFSRLLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1A8</accession>
    <name>A0A2R6P1A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1A8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="434" mass="46496" checksum="8DB8E3A533136F4F" modified="2018-06-20" version="1">MSLLRVSPLRSGNVEEVATPTFNSDIPEPSCLAIHPVREIALGSSRELDEAEGAVPMSLPELGPDPPKEAEAISLLHSVQSLPHEQSEQPAVVASVQESSFPPAHASSQVIPTENVDEEVCLAEPALVPLPEQHLKLLSVEYLQLDNSARPDVSTIIGQLEMVQDIILSKDDSTAGSSLENVAVPLEAVEPTYNGPTLVCSATKAEVPIEQSDVAQSNKETIPPFHTLGPSLSDSVEVSGVAQLSQLPPVAALHSLNELGIHPQAAVSCTEKEPCAIELPPSPLLVPQTGECPSQEKLTYRPMLPLADSSSIVQAVLDDVVEVSRKTEDLSDMDLAQRPILPLTDSSSAIESAVGPVVSQDSHAARHEVGRNDETILRLAAETHDTSSPIDVVARRTWKLEMGVTQKHIPVCVRAVHLTLGYSLTWWLSKSPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1I0</accession>
    <name>A0A2R6P1I0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000562">
        <property type="protein sequence ID" value="PSR83331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1I0"/>
    <dbReference type="STRING" id="98765.A0A2R6P1I0"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50411" checksum="25F1ED1DBED7E2D8" modified="2018-06-20" version="1">MLALRRVPTKLLYTSLVRGNGTVATPLTAAAPAPPPPSSPPKAKAASPSSKPSAPKPASKPASVAETSTSKTIDVDEADSDKKDRKRKRRFRFPTQRPSISLERPRAYSRPIGVGVLRAYDEALAYIKKDSNVVKAELEEYKASLAKAESSPESDSSKVERLKEKVKILEIQSEINLPSVRWKARNGLADLTKPIYRHLVEQRWREDGVLDMLMERIYQMNVVPDLLPNMRPTLDLRVNFPEAPPDNVYQRTRVKRDYEKVEPGIFLLPEQTRKPPMLYTTVFHTDTRLYTLLMVDLDVPDQENASYKPYLHWMQPNIALSALSPSPIPLTTTHTRYIPPHPQRGTPYHRYVILLLPQSSPTERIKIPAPTDEQRLGFNFRAFAAQYGLDGAKGGGVHMWREVWDETVTKIYTDIFEIEEPIYGRMPTPDRYVGLRGTKKYIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1M2</accession>
    <name>A0A2R6P1M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000566">
        <property type="protein sequence ID" value="PSR83057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1M2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="405" mass="45751" checksum="C9C47C9EE596C0F4" modified="2018-06-20" version="1">MPFGDLPTDVFSQILAQADPKTLASCALVSQVCRLLTLQVLFHDLSITFVDPEFAAKQRSQTTYDERIPNREKTLEEFLESIDDTRRIRKYVRTLSLRISRKVKFDDIRPVDPVTIMKILQHFPRVHHLHTFNIFVASGSRYATDLLPNPVLHSIHIEVGKQPSSGQFSVRLKTAHKVLGVLSIFDNIADIVLDGMKFDEEDQHQDASVRILRNGQVESLRILNGIHLPPILRALTGTATSRLKSFACGELEPKELTEEQCSLLPSCKNLLSLGMEITIPDIDTPPDEGDCEDFTWQAVSHLLAHPNIQYASPEYTPPYPHLHNVTFWLAFLDSIHLEMSLYHPKSKSAMRTLDVFLSELPNLGRVVFALKIRGDPESFPIPGDAQHLLEAELPRLRAKGMLNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5C4</accession>
    <name>A0A2R6P5C4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000531">
        <property type="protein sequence ID" value="PSR85586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5C4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9343" checksum="051B88BFC708E58D" modified="2018-06-20" version="1">MPLSLSPSFPGAMELDNNKFAIVGFPQPQETGWAGIEEHLGKYDEGEMKVLNDNMHRVLISLKSQMTYNLVPGNLPRWTQVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5E4</accession>
    <name>A0A2R6P5E4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000528">
        <property type="protein sequence ID" value="PSR85647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5E4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="495"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR85647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="545" mass="60335" checksum="57431E97D1A7B0D5" modified="2018-06-20" version="1">MDRMNSAPCTPTRPRHGVLSRIQPSRYSAPVTPGRVRYQHLCSRHCCSQVVSESELRELLAHSKEDLLEGLDIPPGLDVETDIPAFPKFTDSFRGICDKYNHLRRPTQDGLPQLCPMCLGGLKLHMGRKPELGGAWILNIPPCPVHVEEIREARKQDMAKQIEWLRTRSPVKLETPRSSPVKFETPRSSPVKLETPRGSPVKRDCRAPSRIQDPAPTTPPNGRRTWTTRSGPLVRPTKTLPSERDGVPVREEDVSDDEFPDVRVVIAESVKAHKAAAAAAAEREREAIEYIVISDTEVVEKPRRKAKGNNVGPARPRKKTVKRRRSDVDEAGYVETSDVEKDTVNIAGFSGRTLRNPKKKKYGVGGSAAHEDLETANALSAQGVPTIGQATTSTSITMTRPTAVSTSRAFQGALSSSASSAGDLTTIEYPPKGELDLRVVVWIGPKAAVVVERNVPVVFRFMDLKNACKMCPVMPDTMIKIWSEYIGDWGWHRCDEMLTMRSGRFSVLVRFAAAVEIDQGEFFQELSLLMNGDRVVGHSDIATLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8M9</accession>
    <name>A0A2R6P8M9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000517">
        <property type="protein sequence ID" value="PSR87149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8M9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="185" mass="18970" checksum="E94AF18C4FC9444B" modified="2018-06-20" version="1">MKLIYSFLPSELGFQQCTEFQCNLWLKDDSECLNHIKQPAYVYLGRATSASSSQVSSVTPSSTPVSASSGISSSTPVTPSTTAVSLPPSSSLSSVASTTAISTPATVTIPETTTVTSASSQSGISPPPSGSQTSTVTRIVTSSPSVLPTLPPSATPSTSGTLVNEPHMLSAVLVLMSGLIAFYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC92</accession>
    <name>A0A2R6PC92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC92"/>
    <dbReference type="STRING" id="98765.A0A2R6PC92"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="84"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR88914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="338" mass="38663" checksum="E3E8B24D34DF5A6C" modified="2018-06-20" version="1">MLPLSPFTQCLGILLLFTLPIFKWLRIRYTKQAGKNTVQATKDITTPQKRPESQPLSSQRDEVDPSRDNIDPTAAMQPYQPYDAFLVLDVEATCQPGTDFDYANEIIEWPVCLLRWKHKDKNGNASRLEIVDEFRSFVKPVWRPQLSSFCTALTGITQDNVDSAPLFHTLLHTSFHDFLARNGLIDAVTGARLVPFCWCTDGPWDVRDFVVKQCFISKIRLPPWLSGDVMDVRRVVTRWLEKNDPQRRATGSVAFTSPRRKSLPITRQLHLLGLGAFEGRQHCGIDDTRNVARIVIELARQGMPLRANTPVNPRRRWQWMGKNGKVLEEFVRPATPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG08</accession>
    <name>A0A2R6PG08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000495">
        <property type="protein sequence ID" value="PSR90484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG08"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR90484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="12201" checksum="BE8F0612210463F2" modified="2018-06-20" version="1">MEARALPDNQTYLRRRVKIMPLVVSVPCIVRLRNRQHRQNLKGQVERAPFKLQRFQDWQRVSPEDYAEWQRKNPEMSSDSDDESGDASDEGHTSQRSGLSEWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN23</accession>
    <name>A0A2R6PN23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000467">
        <property type="protein sequence ID" value="PSR93878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN23"/>
    <dbReference type="STRING" id="98765.A0A2R6PN23"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR93878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29651" checksum="59A97882F3201ACD" modified="2018-06-20" version="1">MGKCGDITPPFFEKASFVERIVERDTRKYSSRLKLILTNSPTAKVSGGHIIGGSSAAPSRGASSYAGNEATTFGVLENGQAPKGIVVTTGQRHSVSASPPSLPSPGVGARRKGQKSSPKLPPSAFTPPNAGTSDQFLLAPSPSSIQPVKIIDAHVVAQNGDLIKRENSLQLIQDVFGNYVVQKLFEAMTDFGLATTDRMSTEFRTECQGAEIAPLSNDIWSLGIILLNLIMGRNHWKPASPDDCTFQAYLKDPRHFLSTVLPISNRLAVKSIKNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN40</accession>
    <name>A0A2R6PN40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN40"/>
    <dbReference type="STRING" id="98765.A0A2R6PN40"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR93737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="216" mass="23175" checksum="FB728D9174362890" modified="2018-06-20" version="1">MERVTVGIQTMLPSMLSAIQDIANSTNPLRLHYSAISYIPFMSFFNMTGLVESGDIVGGIVNYAAAVVLELRQSSSDSEPVIRFQYKNGTDDVLHNYSLTFPGWSGDGDVPISTFINAFEPAAVNSTLDWCRICGQDSLRGCDQLLAAAPTRVHQRISPVGAGFLGAGLTVAVMSAMFAALLLLGFLTFGPPGRRSCARRELHSEVNSLSEGPKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN92</accession>
    <name>A0A2R6PN92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M24 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN92"/>
    <dbReference type="STRING" id="98765.A0A2R6PN92"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="8">
        <location>
            <begin position="236"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR94075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="428" mass="46685" checksum="3B237219BEA8355C" modified="2018-06-20" version="1">MSEKRNGARHGLYQSGTTAAFISERTMFRICITFSIAMMLSLLAFRLRNPLAPSPVADFSGLKEHCAHVSPIPTKSFIKRQDLLAKTLHSLGASAYIAEPGANAGFYANLSGSHWHLSERPLLLIVTPTVDEKGAIRGNISILTPMFEATRARLLPIPSDSEITFPEWPEDMDPYQVALSAISDLDDGTIFVDGSTRQFVVDGLQKAAGGGSKVVSAPVEIRRLRERKSKEELNILKCANEVTILAIREARRRMHIGMKESEARSLVRTALSAAGLENLDSITLFGPDAALPHGTGTNRELQKTDFVLIDCGGSLHGYYSDVTRTFALPGSEIPADHLAIWYLVFAAQSAAIETAKNGTITAEVDRAARRTIHAQGYGKYFTHRLGHGIGLEVHESPYLRGGSEDVILTGHTFSDEPGVYIEGQVCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNC2</accession>
    <name>A0A2R6PNC2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNC2"/>
    <dbReference type="STRING" id="98765.A0A2R6PNC2"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR94109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="27626" checksum="D259CD04BE0D87DF" modified="2018-06-20" version="1">MSRVQATQLFRSCSSSFSSRHLARSSFNAANRRVAGARLYSAESTKGAEQKKTEEQEEKDEVTVTPEHELLQKLKKKEEEAQDLVSRLRYLQADFLNLQRNSAREKEQTRDFAITKFAGDLLETVDVLAIALKSVPQPMLKPASSESPSSSSQSSAPSEKSAEAYLTELHTGVEMTHRLLLQTLFKYHVKPFDPTGEKFDPNRHEALYQAPVPGKEPGTVLECQKIGYTIKDRILRAAQVGVVQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNE9</accession>
    <name>A0A2R6PNE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNE9"/>
    <dbReference type="STRING" id="98765.A0A2R6PNE9"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR94132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24346" checksum="8AB804CCB3BC7F25" modified="2018-06-20" version="1">MHTSEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTVKLQIKLGQERFRTITSSYYRGAHGIIVVYDVTDNDTFTNVKQWLQEIDRYASEGVNKLLVGNKSDLTSKKVVEYSMAKEFADQLSIPFLETSAKNATNVEQAFLTMAKQIKDRYGCSLLIKLMDTYSPHSMGSTTTTSGTGKSSTITPGQTVQQNQSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PP56</accession>
    <name>A0A2R6PP56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v4539</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PP56"/>
    <dbReference type="STRING" id="98765.A0A2R6PP56"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="18">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="225"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="481"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PSR94111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="675" mass="74633" checksum="A0C1172D439C45A5" modified="2018-06-20" version="1">MPPKADINKAGWEQSEFPILCETCLGDNAFVRMSKQEFGRSCGTCARPFTVFRWNPGTGMRYKTTVICQTCAKIKNVCQTCLLDLEYGLPTQVRDTALAVQNEAPTSEINREYYAQNMESKLEGSRSLLDSNRASSAGKEMLKQLARTDPYYKRNRPHLCSFYAKGECTRGSECPYRHEMPVDNELSKQNIQDRYHGRSDPVAHKILNNHATSMGLTPPEDQTIMSLFLTTLPASATEDSVRTHVLQSLPAVQPSQLKSIVYVAKSRCAFVNFKDRAVAELAAAAWASGFEMDGQSLGVKWGRMLLMLELVKETCSAAITPLEQPPSANPSESAPPLATLRKDFLSLLTFVYTTTTKVALTLRPSEPAYSASIAPLQSLATYISSLTTCATLFESHGSTLAEHTRRAAKGVLESVRALAQSFKIITEQGEPSTEDYLVRTGAVHDSVEQARQDLPTDNLAAVRSRWTTDRAMLEDSLNEVVEMSEGNGEGEDEDEFDDDGDEDDWDELGLGTSKKMSEAELERTKKILPMFRMVAMMHKRIILDILKQSTPPKDASATSIDVLPGLSHTLLLACEELVAVLYAPQDSRAIRSAILSLAETVRKVKTSLLSTQLLPDIRPSADVGSLEKKMGQVSINNETPAKKERNVRAWFNTCFEQIEKLSQTIGSSLETNNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVN3</accession>
    <name>A0A2R6PVN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000443">
        <property type="protein sequence ID" value="PSR97186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVN3"/>
    <dbReference type="OrthoDB" id="2754842at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR97186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="178" mass="18977" checksum="B2185A9706EED783" modified="2018-06-20" version="1" fragment="single">HTTAVFTADPIFGTSCSDISAPSRVNFDTSIAISLSDALVLAVTWVKTASNLTEGARIGMRTPLSTMLLRDGTIYFALQPILISRFLLNLRQAGSPELEIDSQEAFNSRFSVPGFRVPSLASIIGNMGEDLDHGGPAEEVEDESSIEVEEGAAETTIETHASSTVNPTPSTSRLIHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVP1</accession>
    <name>A0A2R6PVP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVP1"/>
    <dbReference type="OrthoDB" id="2641762at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR97590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="322" mass="35529" checksum="72F17F40D9385792" modified="2018-06-20" version="1">MSKLTRAKLSTYIVMLFALATAGIGLQIWWTQIAFIENQGYPGGPNRFMEDHLESPQNQAVTAVYLVLNWFADGLLLYRSYVLHGALGGHRRIALAFSVCSFIALIVTASVFFNSIAGLGLNLWSDMSTVAGIAYLVLSLSLNTVLTISIVWRILWIRHSLRRSLGPKHGREYTSLVALLIESAALYTIVALVAVIACGLNSPIQYALLPVLGQLQAIPPLLILRRVVQRRALTEETCPTLHFLPSDPINTKEFSPLHRPKTHSQTLFIKCTVDVTSDAVESPLSASSTYKDPEIGLSEDSASPLSEWDMSDLHTMRMNGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYW4</accession>
    <name>A0A2R6PYW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000426">
        <property type="protein sequence ID" value="PSR99045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYW4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015351390" evidence="2">
        <location>
            <begin position="20"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR99045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="526" mass="58431" checksum="28B42C83E9B4E558" modified="2018-06-20" version="1">MFILYLPLLGFLALMGIYSNTPQTILTYFHTSIRTLDVFNIPTIGRTIDNSELQIHPTPLSLPGSSIHSSKPRVHHVYVTTQDGTRFFVLSALVMVAWLVYNLRRNTHMSDPRAECTQVSFGSYESASQFLDRNLPHGPLNISRTASTKDEDDEEVEEIEELISPKVQEQCNVPDRSLEWALAVVGRQADQGRQGSPSPPRREAMLRKVKRTEVRPGCGPMKLIGAPETIEFEGSQASIVEYHSVPAALTTTQLSGVSNGSGRDSPRLTEFEAAPSPIGPSGHPETFNTLKNRTYPPRAPATPGPCCSAWPPEAPSPSKLPKLCSSFFDKSINDIVASDGGSRPSVVRPPPRSVTPPAAPPASPTSPQNWRDRQSRPTLADSGLRMLKHWLGMERRRERISQNREPRNGPRSARTPAKAVADRFSSPKTKGICMTWADEMEFLDDLDETLVEQSSMFSATRKHVVEFPGKKLTKSAEDAYHPAISQRARKERRPISVQSRKRSVSFKACNDLEDSDEEIILYNPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2Q4</accession>
    <name>A0A2R6Q2Q4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v4090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000405">
        <property type="protein sequence ID" value="PSS00863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2Q4"/>
    <dbReference type="STRING" id="98765.A0A2R6Q2Q4"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS00863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="333" mass="37514" checksum="C48FE7D7D26E9648" modified="2018-06-20" version="1">MSESMPQFPPDTSQQTYLAVQAIVAGRLYLRDKRVFQDSIHLPDSSGFRAPDFCFLIAHPTKGRILFDLGIRKNGKGYPPAVEKLLGIFELECEDDVADTLKKGGIDPTTINTIIYSHLHWDHVGDPTPFTNAQMIIGADAQPLWLEAYPSNPNGRYQELPADRPITYISFDPYTSTHPIISPIGTFEKAIDLFADRTLYLVSAPGHMPGHLAALVRVAPNSFIFLAGDTCHDRQCYDPGERLISQENYMDLETARDTVTKLMRMNREMDEVIVVLAHEKERDGTMPVFPEELGTWVVNEIRKRKASRSLPTIVSTASLILTNYPLVFQERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7N5</accession>
    <name>A0A2R6Q7N5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3977</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000384">
        <property type="protein sequence ID" value="PSS03525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6Q7N5"/>
    <dbReference type="OrthoDB" id="2801422at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="211"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="517"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS03525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1299" mass="145801" checksum="6E984ED33536F8D1" modified="2018-06-20" version="1" fragment="single">MDTLDAEMLATLKIPELIEVLTGRLTIPRSHMKRKEAIIVWILEHGSDDIHAELLAMCQAKAASYVANERERKRKRAASRRTQRKAQRVLHVDAELKHDTEKYLELPSQDELLQCFREFIIATSNDGVKHVICGVCAREVHVKEADVQCLLLEDLPNPDRLVPQHSHPEHNLYHGVLLQPEGVITNNCGSSSVNVCRECYKDLQGTDEGPPAMSLANDMWIGPIPWELQVLTVPEQLLIALVFPRVYVFKLFPKDRDFHPQHATLQRGMRGNVSTFEQDIEGISDMVDGRLMPQPLALLSSVLTVTYIGKGQLQKASLHSTFRVRRNVVRRALSWLKVNNPKYYGHIEINESLLDSFPEDGVPSEIVDVIRHSTDTGLVDEESAGYVPDEDTVGDDPDVIPFQVSGSIDTDLTKMTSAELMMWGLANLWKEGREGGYSVRHGKQPVRDLPPRRPAATGAEEATSPSSSTSPSSSQPTTEDTNALSLNYFERAYPCLFPFGRGGIEAVRPKRVDFGTHVRWALQYHDRRFRKHETFPFVAFGIKQKRQALDHASIQMRRGDFERDARVMATLTMEKLERARVEEEQGLPPSDPAVKLLRKHVHATAGRVVGTDNARIRMRSELRSTSIAHGPPSLWCTWNPNDSHDPLAQALMGEQIDLDEFVATVGPDKDRRARNIACDPYGAAKFFHFTVNAILETLLQVQSTKYQVKSAPGIFGKVSAYFGTVEAQGRGTLHLHLLVWLKNTPSTDELAEMLKTEEFRDKMKDFIKANIRAHCPGLESAETVKAIPSDQGVGYSRPPHPDCPTYASDVRSLEQRLARTLQVHTCKLRRCLQPNRHGQLVCKRKAPWAVNEADFVHENGEWGPKRTYGYVNGYNPAVLICGRCNNDCKLLTNGRETMNISYYVTGYAAKKQGRQYNLSAILAQGFAYHIEHGSPHAEELRDKQRLLIFRLVHAINREQELSAPMVISYLMGWGDAYRSHQYTPVYWSSFVSALTKSFPDIQKPSSAVNPPSGVNIVAPSTPAVDVEEQEQAAQCMPRMEGGNEEEPDDDMVTLDLNPRGQLYAKNQVTDYCLRGQELHSYNIYDYFTDTYERALSDKARTTPTGSVLPSGSSLATAVSSDSASSRGPVAGLEGPPASDSEDEGQGPQRRGRQSHIHSKYHSSHPHASTKCRIVRATLHRNIVNFVGRYFPSRDDPTDEPFYCASMLMLLKPWCKLEVDLKRTDQTWSAALEEFLSSAPENVVRIMSGIQYHHDCRTAARNRDNEEDLPMDNAEVGRDRDENELGDGVVEPDTVITEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBQ5</accession>
    <name>A0A2R6QBQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000367">
        <property type="protein sequence ID" value="PSS05545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBQ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="14336" checksum="67685438350D4105" modified="2018-06-20" version="1">MVQQSPHSQSSPMRYCDHRYLTKKYWFPIPAYEDRLLEPPGGEASRIFASPGTIQWILVGIAIPLHGGEFEASCDGLCTKARYPAPTTATVAVQSPTNYLEKISIRSSSHTARVQNLDLAKTTTPSVEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEI3</accession>
    <name>A0A2R6QEI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000363">
        <property type="protein sequence ID" value="PSS06521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEI3"/>
    <dbReference type="OrthoDB" id="2680369at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="128" mass="14340" checksum="3E7A68C17175BD0D" modified="2018-06-20" version="1">MSGSGWFDMFTGVVSLVVVFCGMLQQLLPSTWLSLLEDSLKDVETSIRVAGEEGLLPIDTALFIRLTELRRDFDQLAVRVYAAGNWFQQFLEMLKGLTCKLSVVHKSVSAVKAEIAIWIEVLESRSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIW6</accession>
    <name>A0A2R6QIW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000327">
        <property type="protein sequence ID" value="PSS09342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIW6"/>
    <dbReference type="STRING" id="98765.A0A2R6QIW6"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS09342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="48197" checksum="DC4A0D7046F67B95" modified="2018-06-20" version="1">MSADTSDASEVLGIVLMARHGDRRGFYQDPLTYTPSATSITPLGEQEEFALGNFLRSTYLNPKSPTFIGASELFNQSQVAARADAGGEGGVIFDSAIALLQGLFPPTPDNKDTLADGKTVVAPLGVESVEPNEDVSLEGFTSCPQLDAHTAAFYNSSQFLAVANAAAPFLAKLPPFLDGRDVTLVNMARALANFHEYGVFSDVDFSGIGNIAFRTMLPSVLTAFQRIANASDPLKIHYSAISYKPFDSLFNMTGVVNLGEIPGGVVSYAAVVVFEVRKPSHGSEPVLRFKFKNGTDDNTLHTYNLKFPGWSGKGDVPLSTFLSAFEPAAINTTTQWCNVCGQTTLRGCADLKGVPGPPTSIQALLEAPSAMSSASAGDTSCIATYNSDRISPVGAGFLGAGLSLAVVTALIATLMLFGLFSFGSKKSKRSNNDIVISDLREANLGIEKGAMKAQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM45</accession>
    <name>A0A2R6QM45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000324">
        <property type="protein sequence ID" value="PSS10983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM45"/>
    <dbReference type="STRING" id="98765.A0A2R6QM45"/>
    <dbReference type="OrthoDB" id="3266915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS10983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="387" mass="41650" checksum="603C9022BD1E1C1E" modified="2018-06-20" version="1">MNVWRSATDMESSVVHTRTPGTALLKSRGALQENATYTGSRMAGNMKGKNAMQTPFRPATLARKAIHLGKSNILPSGPLGDKTPFPNRQQVRPLQTPAPQTGKLAQLASLDPLLSKTPGALLLPSARRKSLRLPRSASKKFTTPLQQGNYWDVSDGDLEADVSGGSVDLQEVRGPDYDEIEYMPPKLPGQPYEPPSDMPNFASLGQVLLRTAHADLYDDGTDRYYAIDIALQIDDVELLKESGAFADDKLVLSELGNDDPFEVLSTIFPNTTSTRPLRSTTTTKIQPTAASAPSRPVTRAGSSRSTSSVNNSRPGTSTGVTPAAIPPRFSSVTTQPPVERPFNSRILTRAASRARVTEVTANTTAPGPATETLTLIKTRSLAETGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QUJ0</accession>
    <name>A0A2R6QUJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000302">
        <property type="protein sequence ID" value="PSS15420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QUJ0"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS15420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7324" checksum="F23D6FBF1831FDCF" modified="2018-06-20" version="1">MTTLWETGYIEITDLHTRLGPGPGKVTDPVRFWSGYAIENQTNKDYRQILALISEEFITSACQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHT5</accession>
    <name>A0A2R6RHT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHT5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10227" checksum="94642CC2BB614BDF" modified="2018-06-20" version="1">MPLSSYTPVTPGQLINKTRSARLIVDLESRPVEGLTVQTHPRIHLGPLLVSRLLGPTSGSGESLLLWTIVYEYNTASINDNTAIAYNVKQGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHY3</accession>
    <name>A0A2R6RHY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v2769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHY3"/>
    <dbReference type="STRING" id="98765.A0A2R6RHY3"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSS29621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="293" mass="33054" checksum="71B9C27EA456846D" modified="2018-06-20" version="1">MASQYTTRQIGAANTLEHRVFIEKTSDRSVVSPFHDIPLFADQNNGILNMIVEVPRWTNAKMEISKEEAFNPIKQDIKKGRLRFVRNCFPHHGYIWNYGAFPQTWEDPQQTHPETKAKGDNDPLDVCEIGEQVGYVGQVKQVKVLGIMALLDEGETDWKVIVVDVNDPLASKLNDIEDVENNLPGLIRATNEWFRIYKIPDGKPENQFAFSGEAKNKKYATEIIHECHEAWRKLAVTGESPAKTASYDLSIRNTTIPNSPGHTSKNDPAYSGLPADSRKAPAPVDPSNLWLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHZ4</accession>
    <name>A0A2R6RHZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHZ4"/>
    <dbReference type="STRING" id="98765.A0A2R6RHZ4"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="43801" checksum="032073E3D16827CC" modified="2018-06-20" version="1">MDGEGIRAAAMIAVTRGEPMALKDLRLTGLKRVTDSMMSALGKAAPYLEVLDLGYCKDLHNSAIDAFTSCTEEEAARYEAISLTSRDAGRNLADPNRHWRRVTRLRHLVLSACILLTDHACSHLAHAVPKLEFLELAGIGPELHDNGLVRLLNTTPYIRKLDLEDATEVTDDVLLALTPTAPTSVPPGRSRTPTPDPGHALEHLILSYANVESETLSDLVRACTRLRVLEADNTRMTGLVLKEFVHLARERKVTDARIVAVDCRSVGEYVVKELAGHTRPRMGWLSWHARKLAYLDGRDGEGLGVGQDECDSSRVVVKTFYSWQTVDAVKAAREKKRKSSTRRGLNVSGSSRQSEEVIITSSGRTTRWWSPGNRRGSSAPATPTLDLNTDRGEGCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI56</accession>
    <name>A0A2R6RI56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI56"/>
    <dbReference type="STRING" id="98765.A0A2R6RI56"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="395"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="559"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS29703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="91211" checksum="8BADA8027C0C04C8" modified="2018-06-20" version="1">MQNMSSSTILPKNRALPRLSIDSTLSHYQRSSVSSISSLFSSTRASIALSIGSSVFSDGDGFFALSVYDFDAADRDQLSFRSDELLEIVKQEDSGWWAAIRVSDLKVGWIPSAYVERISDEEAEEVLIPPTERQQLLEVYENGAGQIYGAEVVADYSRSPYVVTPGKGYEWMPMLDNGDKLLPPTPHTSDGEREDFLNDMTSPLYGPLVFSSPGAEQRSPGQELILSASKSTRYGPCPPSPSIPPPTPPPKTAPLRSNSEKHEPTTPRRSHSNPLSSSAKLPSPGDSASPFQARYVRRRPVLINDQVSLQRLSVLLETQSIEDIEDICGTPAAVETSEPGWASTRVHTSRASVDKVKRITGDDEAQALYEAMAAQASYPWFLRPVHNGEEIKVEYDGTITNGTLGAIVERLTLEPLNPSHETKLRHVFLNTFRTMGTADEIFDLLLERYDLDAPQTLTTVELEEWRTKRLLPTQRRVLSIFTTWLVNHNMIGDDPPIARRLQEFLSEISGPADNLSMANQAMKTLECLTFSVPISPVTPVKPHKRRRTKDAKNELLRMDPTVLAEHLCLHEYRYYSKVRPQEGLNWIKTRTGESVANLLAFCALHDKLAAWVKHSILWTDGLGRRADVIELWIKIAEKCRAMHNYSSMSAITTALSSTVISRLHLTWAHVGRSSHLEPLKRFNEPAGNFSAFRHAQQSLDVPCIPFIGMYLTDIVHINDQYMDSTVSTNKSSNEKLFSFVKRRKWSDALDAMLYHQKKQYPYVEETTIMKFIETNLKVSAEKEPSSFWDRSHEVQQGEVASADIRKGLEAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI75</accession>
    <name>A0A2R6RI75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI75"/>
    <dbReference type="STRING" id="98765.A0A2R6RI75"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF75">
        <property type="entry name" value="MYOSIN-16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="933"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="821"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS29717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="999" mass="111382" checksum="8EBC6BC2628F428C" modified="2018-06-20" version="1">MSEDDRAAKAARARALLKKRQQQKVASSSTAGDSRVASPSPPPSRSFTPALAETTPAPRVENDSKDVGTLFTNGHNVAPDTHWLSSLDRVDGPTPPLSTFRHHPSSAYPTPPPLLSPPASSPSISPRPPHAIAPLTHPDVGGQTDLRTLIQEQARAIASLEAEKVSLNVSVEQLKHADTKLQQMNDVLQSERSKTEKLQGFLEHAESDVEQLTNQLEEHNIRLASLESEKGSLSRQLAAAKTEAQKSRELFQGERNKVENLEEVIQRMEKDMSELDVRLEQKEKSISSLQFEKAALSACVERLKGSESKLLEAQSALKAERDKTAASQRRISELEASLQDLSSKLDQQQQTIALLVSEKSTLSASLERLKDADARLQETSDLLEAEKMKTEELQEAVQRLEAEGDESSERIAELSAAEKSFIDKSRDQERALHLLNSELTESKSRAEQYLRRARELEEQIETDDRAERLESILQNTQDRADDLEIQISNLKQASERNDLEARLQAQSHIETEWQKRHAESEKLYASIQEQLTSTATKRDNLLQEKSTLESQVYAAQTSLNELQHKLAQSTSELSTSVRSLQQAQSELRAANRRADEAEKIQADLQTEGIGLMRSLEEMRPKIVELTDVKLDLGEKVESLGRTLKDRDETVAQLEAKLEELREQQLAAQRKQQELSGALEKEISHSNESNSELQEAYADLQKELETTTANAQSLEGERSQYRHTASRHMDEISRLTASVQSHSEQVSSLQAELEERQRAQDEATEFLERAHSEMELLRAQLSAQDEELERHKEATVSLTVPGPHSFDEEMLNTLTQQHSLELSAARSEIRTLENSVFQAEAKAHSLQRQVAALEDQLAHLRPSSRNSQLPSVPARVSSRNFDHSDDLRRASFGSGRPTGVTRPASPPSSFEGLSAETRHKRKVSLSMLKARIDSETATAKSHPSSRAMSPAVKPTSLPTVVEPRSAPGTPPPQHLGRTSQFLDESHIFWCHSCRGDLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLJ3</accession>
    <name>A0A2R6RLJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000234">
        <property type="protein sequence ID" value="PSS30900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLJ3"/>
    <dbReference type="OrthoDB" id="2757804at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="23254" checksum="219B06A59559067F" modified="2018-06-20" version="1">MAEVRRALYAEKVKAPGTSRALVKRPVDKLDPEMDDLVNAGEQGFMYLCCDLHNPSAFDYIKAPPLLKPSTTKRSRLDPEQDTTTQAHQELKKNLNDWRDSKTASRYTATLLANIGASLVLPNNTLQRIIKCTKKHIGTIAELQKQTKWYHIGHGYCQPLFSQACRSAYDSGPTAFSSFNIKHSWCKCGAKCSSTHPSTKDEGRYEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPU5</accession>
    <name>A0A2R6RPU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000202">
        <property type="protein sequence ID" value="PSS32036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPU5"/>
    <dbReference type="STRING" id="98765.A0A2R6RPU5"/>
    <dbReference type="OrthoDB" id="2782847at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="575" mass="64905" checksum="17026BDAF349D188" modified="2018-06-20" version="1">MGTRGYKVYRHKRWYFVYYNPYDSYPEGLGVELLSSIPTDPEEFQKWLQAHRASLDELLAEREELFAIDGKLDAYEEEKRLPSGVLITREQPTNDIMIEWVYEFDLDRLIFHIDSIPMYHLDHMPPQDIFLEGIDLDSYGHRRCSQTIPEEYQFTPNSILPPPVEDSSLQTFRNQPNAFIPISPHDLLGVAELPSPIDVVCIRATEVNIAACLRVWASSITQEVMLAERREELSGIAVAVSLSLASIALLPIHIHLFKFSDDNPLTVERKQPDSFYWMRRHICLTLATHLQHERNLEAAVSGLVDEISNKSEAQGIVFGVAFSVLHCVLVRVDKSAGGSWRHSGALQFLPSFFATSSSDTPGITTLVRLRNLQVKDDVQFFHSLLSSVPAADPRPSEDKTIQRPNNSGILSLPPEILDQMIVEIEQPADLRNLALTSTHFMCAAIRHLQHPQINANAYEGIILRAVYSVRSDQERKEAQHLEDVQDQNEVKVSEGLNCQWASFATTRTYNGKHCVCDVGVPWSLPTLAESRVAEEDVGGTSARRGSKTKEVNLPNIQVPSLRQPVLGYRTHIPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPX4</accession>
    <name>A0A2R6RPX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000201">
        <property type="protein sequence ID" value="PSS32066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPX4"/>
    <dbReference type="STRING" id="98765.A0A2R6RPX4"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS32066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="23852" checksum="A7F515DA422583B9" modified="2018-06-20" version="1">MSYLATRPSTSAPSDGSRTITVLDSQPRDESGAASNDDAVGTLHLRGGPRARTRRTQRVVWREDVVDNEGAGKKSSKICCIYQPPKRFDESSSEESSDSDSDASCSSCDHGGSARRGAGARRQRPTNGSGNGEGSSSRNTDGGGVVHQLHEDSGEKNMYERVPGKKGQGGPRRERLNVQSSRMPSSHRTQDWTEDAKVIHFRVDQTRGSLDPNESREYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVS2</accession>
    <name>A0A2R6RVS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13339</name>
        <name evidence="4" type="ORF">PHLCEN_2v1825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001323">
        <property type="protein sequence ID" value="PSR70777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000151">
        <property type="protein sequence ID" value="PSS34115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVS2"/>
    <dbReference type="OrthoDB" id="5346979at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS34115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26128" checksum="80864C3656714672" modified="2018-06-20" version="1">MSSSQAPVSGGLSTSPEANKNSNTVPKWLPVSLLALTTAALAVPILLLRRRSTGLAKTLQDAPPPPRRTSSTNLAHAPISAASRPILPARSLEVSEKSSLADNVDDGFNGALYSAKAFGYATLYVITGAVATVWGVKTYLGVRDTKEFADRMRLTILTYMPALSSRIHRLVDPGDITESPSVHPPPRIDIKDSVQHTEWAWPDAEKRLQAAFERDGFSGWAEAALREIEAEGQSERMKRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVV8</accession>
    <name>A0A2R6RVV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000151">
        <property type="protein sequence ID" value="PSS34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVV8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="162" mass="17900" checksum="5987EA5BC016F22F" modified="2018-06-20" version="1">MKDRTGILSGSPECPAQYGWHSQQNNFVPVVQSSGTASDIGVFQQDEPRSEQQTADSSSSVLPMAEMFPRAIKCESPPTRYIFAPTPRRCFEPPQFLPHSDASTYNTNTRTRLGVVDYDTHDRHDAVACIDPKMLVYHPPSAPASAAHSSYMHRSDDALNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVY8</accession>
    <name>A0A2R6RVY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVY8"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="26117" checksum="34C2E91BB8B1AEE7" modified="2018-06-20" version="1">MEQYTDLETGEEYKGIHPTISEGPESEHSALLPSEKHEDFEDVHALQPQPQRQHLSRLCGPRIYLVLAFVAGIASCLLVQLIICASRGDKNSANSGVHPDQEVEVYAPPYAGSSEIHNFPPASPTNVFPSLFPTNVGHAGPTPTGAEPALIATAPSYPVHTGAPHLVSPHKAGNKTVSSHFDLFQHWGNLSPWFSFSYLVNEPASYGGPANFSARLNQAAAGWNASGDLEFMNTWFVLIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZZ4</accession>
    <name>A0A2R6RZZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000114">
        <property type="protein sequence ID" value="PSS35590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZZ4"/>
    <dbReference type="STRING" id="98765.A0A2R6RZZ4"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS35590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="66725" checksum="D0504B13DB1D2D20" modified="2018-06-20" version="1">MAVQANGTAEAPIEVSGLPVVVGINFGNSYASISVLNKEGNADCIANEDGERQIACAISFNGEEIYVGNQAKHQLVKNSHNTITGFRNLLGKKFSEISPSKLSVSTPVVQHPEIADEPAYKVQVLQAAPTPLPTSVANTPAASHAATPRSEPTPATRFLTVSEVTTMFLKSLLQSAEDFLGRKAQGAVITIPSWFSDAQKAALAKAASDAGVNVLQLLDEAGAAAVTTATSPPTEGLSDDRTQLVVDLGASGLELSLLSIRQGLAYSLATLSDHTVGGDAIDDKLIKFFAKEFTKKTKLPLTVAPASEPQDKRAEAKLRLAVEHTKRTLSASPGAATCSVESLKDGLDFTGTINRLRFDMEMRTIYDTVFTKVKELVESAGLDLYDVDEIVYVGGSASLPGLDETLALSFSESIITPFIAGTVVGGGIGDPTTILSRGCVLQAKLIALLAEGTEEEREVKKAFTLDSKWTSAKATSKTIGLLFPEEGAEGSLGGQWIPVVLKETALPCRRTIRFEVDLGEGEGSKKVGFEVWEAKEGVKVTKEQPPKLDLEDDEDAEEDEEIEITEKTVEKENLLTSLLLEAKAAKQQQTRWKTKVEVQVVVGEDGSIDISAQEIGGEKVTAAIPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3A8</accession>
    <name>A0A2R6S3A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3A8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="7884" checksum="EE29E598E0EC82F9" modified="2018-06-20" version="1">MDPLGTVKAVIGAINYLYAASEKIKENGEECKRFCTHASLVMELIQRDIEHTDGGSARVSSKLKRLSKYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3J4</accession>
    <name>A0A2R6S3J4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3J4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REJ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5744" checksum="8D606BBBE853E633" modified="2018-06-20" version="1">MVLGSKVHEALLDATQLTPDAPSPRYHSTARLSITRVVKREVMVKSKVPKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3K6</accession>
    <name>A0A2R6S3K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v1343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3K6"/>
    <dbReference type="STRING" id="98765.A0A2R6S3K6"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="4">
        <location>
            <begin position="195"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS36799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="556" mass="59569" checksum="37E085CC124DF795" modified="2018-06-20" version="1">MPFSRPQTPHKELKLGYCGLGAMGYIMARNLATRLSHPTVQHPIVVYNRTRARAEKLAKEVGESEIKIANSPEELAIECDIIFTNLADDEVVKMFFEKFASALKDSQNTKNKIFVDMSTVYPSLAGELDNLISSIPHAHLVMAPVFGAPTVAETAQLIVVMAGDYRSKKEVAHLLVPAVGRKVIDLGGNLEKAPTFKLIGNSLLLGSLEVLAESFTLAEKSGIQASQVQNLVKDIMPAPVFENYGNKMVHDLFDGTKGFAIDGGIKDSAHIRKLATDVNCPMPALDVAHQHLITARAVHASKRARGHAVHETLDWSSLVAGARVAAGLDGFDSNKHTNFSVPRLIQLRKDITAAALNHAAPAPSLATSSPSTKEPELPTLTVINTQMLGATLREFDTVDPEIVKGLAEMVHGCLAVVTMPNLNPPQLNTILRVLASSVPPPPPVKTPEQLAQQLRASTDNDIPGRRVKRQRAAPIPELKVIGALIEGRLITAEGVKDVAKLPTLDTLRAQLVGLLSAPGAQLAAVLNEASGGRLARTLEGFKKSLEGDGSKPTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3T0</accession>
    <name>A0A2R6S3T0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3T0"/>
    <dbReference type="STRING" id="98765.A0A2R6S3T0"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS36869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52197" checksum="664E01873DFBA6DF" modified="2018-06-20" version="1">MPRAQKPSGKTRHDPLHIQLGEDEQNAKFGKITRPGKRRKSQGVDAEENGEVILDPKTSRKIFELARDQQEELGEEDEEDEEDDEGEVSEKAEFNVPRTKEIDEDDDDLGDYDEDEMEEEVEEIEVDESDLKTLDALLPANAGERRTLADIIFAKLESKDAEKSTVIQKTHQDPSKAPDPAAGLNPKVVELYTKVGLMLSRYKSGPLPKPFKIIPSLPAWARMLALTQPENWSAQACHAATRIFVSQMKPAQARVFLEGVLLDAIREDIRLTKEGQRGHKNNRKLNVHYYESMKRALYKPAAFFKGIVFPLLQNGCTLQEAAIVASVLAKVKVPLLHSSAALIRLANMEYSGPNSLFIRILLDKKHALPYKVVDALVFHFIRLSNTYKARLGESDKLPVLWHQSLLVFCQRYASDLTPEQKDALLDVVRANPHPQMGAEIRRELVNSVERGAPRPDAEGDVEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S431</accession>
    <name>A0A2R6S431_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000087">
        <property type="protein sequence ID" value="PSS37022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S431"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="168" mass="18883" checksum="208320528F229B5B" modified="2018-06-20" version="1">MALTIARLVIDIWQTEMKALVRANVIAEIMILRTSELAEDLTSAAVKTFNLKKWLACKYQFNYKDQSYYHLIRALIVDKDLLPLGLPKGTVATMSCKNFVKKMLHQATKPKPAAPLLKKGPLLPLIQDASKEITHLFSVLQATPQDKESWTMDALLFADSFCPMDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4L5</accession>
    <name>A0A2R6S4L5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000079">
        <property type="protein sequence ID" value="PSS37193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4L5"/>
    <dbReference type="STRING" id="98765.A0A2R6S4L5"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52156" checksum="5D3CA785A8B7EC04" modified="2018-06-20" version="1">MHPWQPESDPEAFLSDEDWELEKIVSEDYDALGQRSYEVGGTLSLFIQAEHSFTAVLQIAWTDWQREDGTNTTWQYGDLSGAAVAVDLWQKTTATRRKQKAQMSLGTDLQGPDIPFHMHRTFEIAEAHREKREKSRGSLSQYSGWDNVPSLSRDAVFVTTSTIASRVSSRSQSSHGSLSSQEPRQITRRKRPAVPFIESSPEPPDSRPSSTKPASHSSQSSRLALQTAWQGACRQAAAASIRICNEVDGEQVPPVIANFRYIETGYDLGTFTFPDDGFLLGCSCETVCEDAKTCDCQAALPHPDDGVIEAKTHAYDANHCICGKSCHNRVAQFSRDVPIEIFRTIDRGWGARAPKDLSKGKFLGLYSGSREEAHNITPERRSYTFDLDTLEDTDQFDEDSKYSVDAYAQVDLSVDEPPLFGICHESACNSKTGTHNRLRPEGCKRYQREKAEKARVKRLQVRCTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4Q1</accession>
    <name>A0A2R6S4Q1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000069">
        <property type="protein sequence ID" value="PSS37270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4Q1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4Q1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="13909" checksum="7028965095F3B014" modified="2018-06-20" version="1">MVARPTPQRPPAIVAAKAADATIETLSARIATLEKALLEQSHQDTQNEWNKASSVSSGLSPESSADSSAESPPSDNCGGPETTVNAANSASNGEDGPRALLDFDVQVAAVALAQLSLAPRTEYIGAGSVICALHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S590</accession>
    <name>A0A2R6S590_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S590"/>
    <dbReference type="STRING" id="98765.A0A2R6S590"/>
    <dbReference type="OrthoDB" id="3265169at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="218"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="361" mass="40676" checksum="4F16F4F62B5A9A9A" modified="2018-06-20" version="1">MYNGMPPLVDRDFAQRPDTMMNGRWPPAPPTPSWQGQSIPQPDMAQGWGGFDNSGWAQQGTTLTPMMMPAQPGPAFPIIPPPMAQVAQPVAMGNNDWARAGSTPWEPPADGFPRDTGRAQTPFRSSSVRSQTPRTPFTDDSSPLSQTSNISRSRSFTGSVRAADKRPPREWRPDFSTTKSPKLVALGSFFSKPTRDPGNVPRVELHPYLRYTPSSPSIYLDLRENPANVHFRDLGRPINSWDLSRFTCEPPLPTITLVSRYFPWYIEVQSNNPSGVTLYDLLWQISICMSTVITAADYWNNEMDQVARERVAEAWALRCGDNQDERNQGIRRVDFLMDRVVLQGFTRSKDGTWEMKVKRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5I7</accession>
    <name>A0A2R6S5I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5I7"/>
    <dbReference type="STRING" id="98765.A0A2R6S5I7"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="563" mass="60602" checksum="44B05CDE0F5ABE38" modified="2018-06-20" version="1">MAQPPYSKFVVRLQRMRNQLTSERQKYLLPHLRPPTATAYEADRDALTAQFDAAEAMLKEIHAETNAVRIAMEEQKEKVDKTTEEINTIIAEMRNDEAKTRDELREMREEVGNVRDMLPKMIDKSKENHTQSLAELQQELKSLKALLLSRGPNSSAGISTPFIPSKPSIPSWQLAGSSSGSVPSSPGISSLIPNGKGKDWRNAVETTLSQHSPKPSLDASADEHTGRGSIDTALRQSLPSSTQLADTALSSLGNLRKTLGTQRPASPVTRGSPTDTSTRPRVTLEDRLRAKFALGEASAGTSPAQSATPSPAHTPTSVIDHPLSPSPSNTGTKDQRPATVQPPELFSPRSVPLPDSPAFLPSVASPTPVIPSLSLVSPSSDGLIENPATSLELSDSPRDSGDASEQPAQEEPDGESIAEASVAGTMKSTPAEQSILPLRDPEESEPTVVEVAHFTPHNTIEEPHDEPSVLTDDIVVSDEAIQSSLEDPSSITQELVNGSGHDGLVLTDDTSLSLAIPVDNKPSEELLSAKQVDQLDIEVLQERLKLVQQRFSGMSKLLSNVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5P5</accession>
    <name>A0A2R6S5P5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5P5"/>
    <dbReference type="STRING" id="98765.A0A2R6S5P5"/>
    <dbReference type="OrthoDB" id="2977329at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="380" mass="42469" checksum="1E9C0A1013285347" modified="2018-06-20" version="1">MSSIPPELSDYVIDFLHDDRPSLKACSLTCRTWHPAARHHLFRTVTFSSPRSREDFQQLLHAAPYIGQFARDVRLGKWSPYVAKGEIYKPEQLSMIFCALPAVERLELVLVEMDAVLESSLIRHFTSVTQLSLEYCRFPAFGALVGLLRSFPALERLNLRGVSWEKVEEVAFPARPNSVNAPALRNLVLAKDMELDVLVEWMLSEGLCDNLETFSGSCKHDADAIIIGELLRAAGPSLINLELDWYCASYNDIFLPLEFTVSPCTSLQTLTLNCPIDLHATLPWVSSLLSQVCPASLQKLTFGIRLLGSLDAIDWKRVEAILSPDIFKKFNTLQFSIAAWHTASQRGAEVQSSIRQRLPQLALAGKDYDGGYVNMGNILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5V5</accession>
    <name>A0A2R6S5V5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5V5"/>
    <dbReference type="STRING" id="98765.A0A2R6S5V5"/>
    <dbReference type="OrthoDB" id="3267102at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13369" checksum="C68AC0137FB80F01" modified="2018-06-20" version="1" fragment="single">MQQDNPSTSSSGPRIFIDVRGNPLRVFTETSSVQARPKVVRMLRAGGATITHNPKDSQIILVDSATEAGVALAAIWLDKPVLDAAWAYQANNRGVYAGADEDWGGYRVPGNDADDEEMPLPATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S630</accession>
    <name>A0A2R6S630_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S630"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="13612" checksum="10254C89A45F039C" modified="2018-06-20" version="1">MANPPTTASMVFACSASAAAVYESGGPYTPFGAAAPGLGAPFGPLPPPSMFVGAVGSGPVDDALLEDELLLEVLFPELCDWVGVGVKVKTTLEVNVLSTLDGPRVTPVVNDVERIRDWEVEEEFELLCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6M9</accession>
    <name>A0A2R6S6M9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6M9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="15423" checksum="892E67141048C975" modified="2018-06-20" version="1">MIDVLVRVRHASAVQQLTCFVRPRCLKASAEPRTRDRAEYYPLHRCPWPSLVRPGCLSKFHGYEEWGKGAKMEDIINILTQQLKGLVPGQQCAQEVRARKLAALLSRERLVCTVLDHALTLASRPLRCITCLHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6S3</accession>
    <name>A0A2R6S6S3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000012">
        <property type="protein sequence ID" value="PSS37972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6S3"/>
    <dbReference type="OrthoDB" id="2953592at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="376" mass="43143" checksum="BE248E9B61723BDA" modified="2018-06-20" version="1">MPVPSHCCARVRAQPNEPAVQWFPATHVCKLLIDFIDTNVGAFRRNTQASYCLLERARNIARKINSLIEFVEVNDAWDMYDKYTSSIEPLEDCLISLLDTVEKERDQYLITEQLESIDTCITFIEAWATQRADIRAKLEPLWVNTARNLVTDVINKIKDVQSRLATPHNEMEDSSIVLSIKTVMVIYSTMELIKARKPNALWLECAKSEVIWEAAQILLIQLIAHLENGTPQLVDVQNKYNELLSRLQRGYMTGDIRLPPNFPQLMKHAGRIGRSYHAQALYTVALCRELVEHFKSATNKTVQDFELLRLTIDKTLRALNAARLEDGATLTMFDLEAFDNSEISRAFVSARIEIKRCFDKFGENDFLDGHHMEHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDN3</accession>
    <name>A0A2R6NDN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDN3"/>
    <dbReference type="STRING" id="98765.A0A2R6NDN3"/>
    <dbReference type="OrthoDB" id="2799066at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6553" checksum="6CEFF74FA75E4C8E" modified="2018-06-20" version="1">MAQIGVAWVLSKEGVTAPIVGTTNLDNLKDIIAGANVKLTEEEIKYLEEPYQPLNVIGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDU4</accession>
    <name>A0A2R6NDU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDU4"/>
    <dbReference type="STRING" id="98765.A0A2R6NDU4"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035444">
        <property type="term" value="P:nickel cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="242" mass="26614" checksum="7C0CBCDD09DEF196" modified="2018-06-20" version="1">MCQMEKERRLRLQRGEDPTVIDSDLQDQESHGNTLMMKLIGPIVTFVDRPWKMYPLLFTAGMTLIDSVDSIIMLYSYTGFPDRSFALFDRKAPIQSRTIVENVPNSPDLPFLPSVQLSKTASPVTGIQELRRDTSQGNLSPKASKVSILDGDHGATVTAADVMDDQVTRQLRVKRNAMSGLSVILTLMSILVAFSISLITIMGLIGDNCSSCQEAANAPDGGGLAGRWWRGWADVRPLSLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NED9</accession>
    <name>A0A2R6NED9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001353">
        <property type="protein sequence ID" value="PSR70412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NED9"/>
    <dbReference type="OrthoDB" id="10007484at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="3">
        <location>
            <begin position="212"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="570"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1414" mass="159883" checksum="D11C54BC5A62121A" modified="2018-06-20" version="1">MPHLESSLLAVLTVPELKEQLRGRMEMPRAATKCKADMVEWIIVHADLDLKTHLTEVCEQKCHRIEQTAQSKKRKRHETQRMQRKIRRVERIDRSAEHDIEKYLDLASEAQLDQCFLEFIEATSNSAMKHVVCAVCAREVSVQEDNVHTLRSEDIPHAHRLIPSIPHPAHDLYNGMLLEPSGVFVRTEDCEECVHLCGDCSKALSLDVPSPPPLSLANNLWIGRIPWELARLTVPEQLLVSLLHPRVFVFKLFPRDKDVRPEDAALQCAMRGNVSTYEQDVAGVAAMWQCRLMPRPASILSSIVTITYIGKDQLQKAWLHRTFRVRREVIRQALLWLKASNPKYYGHIEIDESRLALLPDDDVPNEIMDVARQTTDVGLVDQENSGYVPVLDEDSTTCTMPQESEAGLGLHTGESHSADAEPDVIPFQVSGSIDTDLTNLTGNDLMMWGLANLWNKGEEGGYAVRHGSQAVRDLPPLREDAASSLEPGAQRTYFEMAFPCLFPYGTGGVESRRTTGVESRRTTGVESRRTTGVESRRTTGVESRRTTGVESRRTTGVESRRTTGVDFATHIRWLLQYHDRRFRKHETLPFVAFGILQKRAALQHAHVQIRRKDFERDGRVMASLTQQQLETARQQEDKGIPITDPAVQTLRKHVHATAGRVMGTDQSRYNLRSEIRSTGIEHGPPSVWATWNPSDMNCPLAQVLCGAEIDLDHFDATLGPGKHQRAKNIASDPYAAAKFFHFTVKTILQTLAQVRATKFQVESHPGVFGDILAYFGTVEAQGRGTLHLHILIWLKNTPTGDELKDLFKAEAFQTKVKNYIRANIRAYKPGLDSEESIKAIPTDPNIGYCRPPNPGSRTYKDDIDQLELRLARSLQVHTCKVRRCLRPNKHGKQECKRKAPWQCSDDDFVNERGEWGPKQKCGYVNGWHPAILVNARCNNDCKLLTNGADTKNITFYVTGYAAKKQGRNFNTSAVLADTYAYHNSHRNSEYVDELRDNQRLLLFRLVHRINREQELSAAMVISYLMAWGDVYRSHRYTSVYWSSFVSSLLKAFPGLDKAKESSAQSVAALDVTVGQPEEGNRVNGVLEHTESLTEVPRPSVTDNEDNDFVTLDINSRGRLYTKNQVTDYQLRGPELQDYSVYEFFRSTYETKKYPSSKKTPNTTAAAVNDEGDEGIEEPTNERSDEAENEPSLEVIDQPCRLGRERNSRSQYHSDHPAAKSKHRVVRSPMHRNLVNFVGRFFPSRADPTVQPFYCASMLLLLKPWRDPLKDLKHQNQTWIDAFEAFMLDSSDKVRRIVDNIEYPHECRLAADLARESESNIPVDDVVEAGVMLGVDELSLGEDTDTRNVGGEMITEESITAIYENLTPRSELNHARQAIEIAKGLRLFKGQNAEWTVHPGSTANALHWISVGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEE7</accession>
    <name>A0A2R6NEE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001344">
        <property type="protein sequence ID" value="PSR70618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEE7"/>
    <dbReference type="OrthoDB" id="3346544at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="122" mass="13050" checksum="F8C0A5BB079EEC85" modified="2018-06-20" version="1">MHIILDSGLIYTLSVIIFFATSVAGSNAEYAVSDVIVQLIGITFNLIIVQVNTGDILSPGMAYPLTVIPPDGGETPLRKANNGTKTAPTFAIDVEIEVNRFTDVARDSKDNSHWKSDVSGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEF7</accession>
    <name>A0A2R6NEF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001342">
        <property type="protein sequence ID" value="PSR70628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEF7"/>
    <dbReference type="STRING" id="98765.A0A2R6NEF7"/>
    <dbReference type="OrthoDB" id="3204502at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="257" mass="28018" checksum="27D48058C6CE72E7" modified="2018-06-20" version="1">MSPRPRPILKRTKTPSSSAAQGRGQVTYALPFATCKAVHSPHVHFPPTPSIVASTHPAHSPRTYDRKPILVSPNECGLADRKLYSPPADFEVERPERERGRSRRNSTDKDENLSVKGSYFHPRAFEACEPEPFLDDHDEDEDTDTSSSLSPPLLVQDLSTSDDSSSSEDSDDVTTPPDSKLASVTPAKALLPLPFSSHNPFSVTSSLYGTRQVPGSIKLLDGPSMQRPFLKRADKGSSLDLTNGFWATLDEGCLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF71</accession>
    <name>A0A2R6NF71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v13082</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="MLYV02001296">
        <property type="protein sequence ID" value="PSR71034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NF71"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000029">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="14">
        <location>
            <begin position="1251"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="1978"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2277"/>
            <end position="2304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR71034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2304" mass="261491" checksum="59C7E6972094B142" modified="2018-06-20" version="1">MASTAPLLQADVLDQIFAGLRNKSYEVRVQSAIELQRYVSNTVPDMSSDAAAKLWDDTINRRLFDLVHSQTNYDKLGGILAIDYLLNAEGEGTIESKRNLFRFYNYVKSLLPNPDINVMLAASKTLGSIAEIGGAAFGEHFMDYEVQTAIELLQADKQEPGRYAGVLILKELARNSPTYFHSHIGLVFDKILVPLRDARVIVRESAAELLAACLEIITQRERQTRSPFLLKILQDAQMGLKMAQPEIIHGSLLTYRELLLHGGMFMKENFLDAAEQILNFKTHRDSHVRKMVITLIPTLAVYDTTTFSEHHLHKAMAHLLLQLEKPPERSVAFIAIGHVASAVGSEMKPFLDSVMTHIKQGLQMRGKKNAPQEEPIFQCVGMLAMAVGPNLTKLLHDQLDLMFACGLSEPLHQALVHIAHYIPPLLKTIQDRLLDLLSILLSGQPYKPLGAPPLLRGEAPSMARDHNAAEPASNAKSSDQLALALQVLGSFDFSGHILNEFVRDNSLPYLEDDNPSVRQAAALTCCKLFIRDPICYQASNHSIEIISDVIDKLLTVGIADPDASIRKTVLSSLHERFDKHLAQAENVRSLFIALNDEVFENRLIAVNLIGRLALHNPAYVMPSLRKTLIQLLTELEYSSVMRNREECTRLLTLLVSATQRLIKPYAIPMLRVLLPKANDPNPTVAANVLMCLGELACVGGEDVLPHVPELMDVIMTRLADPALIKRDAALHTLGQVCSSTGYVVTPLIDHPQLLQILSRILRTEPSQSVRREVIKVLGILGALDPYRRKFPQSKPEEEAASELSANLANTVQRSSIGSAATPDDYYQTVAINALLSILKDQSLGAQHHKVIEAIMSIFKTQGLKCVTYLPQIIPAFAEVARTSTSRVQVFHLEQLAILVGIIKQHVRNHMPEIFRLVTELWENITLQLPLVSLIEALGKALDAEFKPFLPTILPLLLKVFDGEMSEKTASTQIKIFDAFLTFGANIEEYLQLVIPIIVKTYERPDSPVPLRKRAIQTIEGLTRRVNFSDYASRIIHPLVRVLGQPNNELRMAVMDTLCALVIQLGSDFAIFVPTVNKCLLRNRIPHPKYENLISKLLNGERLPQEPGASDLYSSESAKAPEFSAPAEATKMVVNQQHLKQAWDVSQVSTREDWNEWMQRLSVEFMKESPSHALRACMSLVDVHTPLAKELFNAAFLSCWGELYDQYQEDLVRSIEAAITSPYAPSELVHRLLNLAEFMEHEEKALPIENRTLGEYAMKFHAYAKALHYKELEFFTETSPTIIEALIGINSKLQQHDAAWGTLLIAREQYDVSKHEEWYERLGRWQEALATYEKKAIEDPDAPDIALGRMKCLHALGEWDQLAQQVEEHWANANHEDRREMAPLAAAAAWSLNDWESMDDYIATMKADSADRPFYRAILAIHQNQFIKAMKQVSLARDLLDPELTSLVGESYGRSYNTMVRAQMLSELEEIISYKQHADQPERQQTMRKTWMKRLQGCQPDVEVWQRILQVRALVLSPEDDAVTWIKFANLCRKSERMFLAEKTINSLLTPERLQLQYRDHPQHAKAPPNVVYAHLKYMWATGAHEESLEFLRKFTSSLSRDLQPESGEIVTNPTTKKKLDELSRLLARCFFKQAQWQVAMHEDWSERNIKDILHSYYLATHYDPAWYKAWHTWALANFDVVGYMENQIEGRTDMPGNELAVHIVQAVDGFFRSINLRNENALQDTLRLLTLWFKYGSHDEVSHAMTTGFQNVEVDTWLEVIPQIIARIQTPSANIRRNINLLLTDVGKHHPQALIYPLTVASKSNSLPRRTAAQAITDRMKEHSPTIVNQATIVSQELIRVAILWHEMWHEALEEASRLYFTDHNPDGMIAHLEPYHEVLEAGPRTARETSFTQVFGRDLHEAYEACRRYRVYGEPRDLERAWEIYYGVFKKIEKQLPQLTVLDLQYVSPELLRARNLDLAVPGTQESGKPTITIQSFATKLTVIPSKQRPRRLALKGSDGRDYHYLLKGHEDLRQDERVMQLFSLVNNLLSVDIDCFKRRLHIQRYPVIPLAPQAGLLGWVQDSDTLHVLIKDYRDSRKVLLNIEYRLMLQMAPDYENLILLQKIEVFEYALENTTGQDLYRVLWLKSAGSEHWLERRATYTRSLAVNSIVGHILGLGDRHPSNLMLTKTTGKVVHIDFGDCFEVAMHREKFPERIPFRLTRMLTHAMEVSGIEGSFRNTCEISMKVLRDNKESLMAVLEAFVYDPLITWRLMLTEPDTRRADLNPDRTADLVGAAAHPQGLPRRPRADENDIFNGTVASSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NF81</accession>
    <name>A0A2R6NF81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Squalene synthase</fullName>
            <shortName evidence="5">SQS</shortName>
            <shortName evidence="5">SS</shortName>
            <ecNumber evidence="3 5">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v13092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3 5"/>
    <dbReference type="EMBL" id="MLYV02001296">
        <property type="protein sequence ID" value="PSR71044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NF81"/>
    <dbReference type="STRING" id="98765.A0A2R6NF81"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000023">
        <property type="entry name" value="Squalene synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="500" mass="57115" checksum="18941C8CC9393B06" modified="2018-06-20" version="1">MGALSMLTLLVTHPMEFRILLQYWIWHDQRDVSAPHEHEYTGWNRESMRKSWGFLDLTSRSFSAVIKQLEGDLARVVCLYYLVLRGLDTIEDDMTLPDEKKQPLLRNFHELTLTPGWTFTENGPNEADRQLLVEYNHVVDELKLLSPSYLEVIIDITKKMEAGMADYAHKAQTTGSVYLEKVEEYDLYCHYVAGLVGEGLSGLFAASGKEGEFLAGQLELSNSMGLFLQKTNIIRDFREDVDQQRFFWPREIWGSEEYGAAAGKPAFKEMNEMYLPGNEKQADYVQSAMILNALCHATDALDYLRLLKNQSVFCFCAIPQTMAIATLELCFKNPAMLQRNIKIRKAEAANLIMRSKNPRDVAYIFRDYAQKIHGKCGPDDPSFIKIAAACGRIEKWCEDQYPSFVRMAEGGGQSQQFDPLDPRSIVAQADDERQRSAWLEKRKKELMDSTKDVIKAVQQQDQAANNFEVIKYVGLAFVLLTIVTMGSVYGIIYYLDHFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFC1</accession>
    <name>A0A2R6NFC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001300">
        <property type="protein sequence ID" value="PSR70958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFC1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="415" mass="45222" checksum="C01E243EDFC6CAF1" modified="2018-06-20" version="1">MQTNPKFIPASAKYLSGLVLGQTARTRRQDESVSAQPSILSHDKPLPHVTTSMLKDDADDQLPPPVPPRKNTNERSPTPILKDTKYLPRKSTSDSQASPQPPRKSSRDSLDRPLVDDLPAQIYPTPSRRTPSSQESHAKSHDSTPPVLPLEARADALAKLEGGPTRSTPKKKTVQSSSISGGWVLVTVTSPSQESAESARRHLPAQMYPTPSKRTPSRQESHAKSHDSTPPVLPLEARADALAELEGRPTRSTPKKKTVQSSLVGRGWVLVTVTSQSQKAAESARRHLNTSPEPMKPMESSGGRRPDTRHVDSVPPRDLRRHTVDTAASVSAGNGTLLTTQLKSSRPITGHSRSASLDLAPVCTTERGRPSAQDDLFLEKRVTRSPPRLDVNANPTFQFPPLFTANSRCDDVFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFL7</accession>
    <name>A0A2R6NFL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001291">
        <property type="protein sequence ID" value="PSR71187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFL7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="13619" checksum="138503DF2723C385" modified="2018-06-20" version="1">MASNRSIFVRLLRLFLKPARNVVRYCLIRDLIVEFGEHIEGISWDSHQVLCEMIETTDRRRNTERINIILYLDPHKAQALHTTTASAKIYCICGVSMNVTITPTKGLTFISTIALNKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFL8</accession>
    <name>A0A2R6NFL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enhancer of mRNA-decapping protein 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v13009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001294">
        <property type="protein sequence ID" value="PSR71163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NFL8"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049404">
        <property type="entry name" value="EDC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21289">
        <property type="entry name" value="EDC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Enhancer of mRNA-decapping protein 4 C-terminal" evidence="8">
        <location>
            <begin position="1284"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="833"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1129"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="862"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="891"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="915"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1199"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR71163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1398" mass="151630" checksum="058D9DE41CA1E89B" modified="2018-06-20" version="1">MDPISSRDNLFSRGPSPPPQPQPFQVSQGSDSLGSAPSSHRETAPAAHTTLESLFHNLSAPAQPQVSSQPSVQATNVYPGPPDVPHSGPATPASVNAGSVSSSHSGPTNPASERQNALLSLLGAVTSPTSNQHNNPLMGLVPPQQVPTPPGSAPRAGQSSNESQGKFLLEQLMSGTPKYNNEPQSSSYPVSSSVGPSPTYFSSHPDPQAQPQGDFYGGDSAYTSQEQLPVSEVSHNQPTQQRAPSPTRRSMFDFVSPFDALSSPTTSQSSKRKPIPAEPSATTSNHEESWNPLPVDPKRKSVENLMDQLTRGQAPLAPPAQSVTAQFDPYAPSEETTPQAEPLQTRTSRPLPPQPQSSQYSSSPRASPPKAAMQQRPTRRSVESPIGPPGAQGYQFSQRDKEGSPLPSGPFRHPGIEGRGRTNIVPKGKNSPSVQQQTIVFDVSQPLEDIQAPRDAVKSTAIALVKVDSTFLPGTTIGATHWVAYAMTKGRVRVISRSSGDRTLLQLPSLFPSAVAVSDMSVHGNRLAGVTSDGGFVVWELPEVIRDDVAGRIVLCVLPSNEIDPLHAVKWHTQQPDLVAVASETNLYLINIADAHHIFGGEPIPQSELHRVGQVFSVPSPIIAFDFDVPRNALATISEDSTLTMWQINDKLPFWSNKIRGDDMPSSLTFVDNGVVIGRKNGTVFQLLPVMGRNVHSTLKFVNGGNEDPDMFGHANYDSRIQTLWIANNKRESMIAFKINFDVSTPSPGGEEVRGTYFDQVVEFFGPKPTIHFVILTADADPTGAEAHAACVAAKVPPGDLALVAFSVHSSGVDQVLVRKEWYNSALDSTPAKFPSYAPFPQSQAPELRPQRQIQSQTIPPANQPQAPPPAPVGAPLPRVKTPPSEDIEGLDSREEGRTQEGKPKGKGRNVGWKNNDDGKVKEKEVQGKAGDASDTPLGMVLTKEIRKVEENLHTRIGRLIGKELDKQHQRLEDARTNEQAADFVRQEKILKLISTELTKNTTRVVEMAVKAEVQSSVLPALENITRTEVKAALNNQISKGLAESMKQSLPTEIERLLLRPDVSNHIARTFSSAVTPLVERQVKETITKSLIPAYTQQSSTMHQELSREIHGEILNLKKEVITWQSEALRGQESLIRELEQSVRLLSEQVKYLTINIGPNAQSNLPIPTRSSPGPSSGGQHPQNNLNLNQLLRHPNMPPVNQQPSSYPQSHGSFPQQQQPSAPTHGPWFGPNIAAPQASHPAAPPPVPTQASHARTPPMAPPEEWDDTYLAVLGSQDTRQLRELLARSNPEVVMPMQGHCPLSQAVVLTLVHRLSAVIGETPPVDESFKSSLWWLQRAVATLNTNDPLISPYVGRVMPSVQQMLNTTKQRLAILPGGPLMDTARTISDVQDMLARKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFN5</accession>
    <name>A0A2R6NFN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v13310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001312">
        <property type="protein sequence ID" value="PSR70812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFN5"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR70812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="314" mass="34067" checksum="D219D56929676DB0" modified="2018-06-20" version="1">MSQTPTDAQIVVEFQDTTLDHSVTLTNIVYSMTALVAYEYIITLEQERTIVWHRKWTLATWLFIANRYLLIGFIILSVAPYTSSLLNSGVVGYSCAPAQVMGAILGNLQIVVIAVFSALRVFALWDRNIPMTLLVLVLNLVPGAVDIFEFSKATAVFTANPISGTLCNAISGISANVLFDILFVMDIAAVVVNTVPSFQNFGFIATVIGTLQPILISRFLLNLRQVGSPEIDSQEAFNSQFSIPGFRVPSLSSMVGNMGEDLDHSGPAEEVEDEVENISGSIQAEEGAAPEEIIEGHPSSMDPIPSTSQLIHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFN9</accession>
    <name>A0A2R6NFN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFN9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="6713" checksum="BE02700D7EC475EF" modified="2018-06-20" version="1">MYPALSPKPMFDWDLPHARPPSTEIVPPSKTCVACQAETEDIHISVESEVSIVFFVLLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGG0</accession>
    <name>A0A2R6NGG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v12642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001282">
        <property type="protein sequence ID" value="PSR71477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGG0"/>
    <dbReference type="OrthoDB" id="3226546at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR71477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="9907" checksum="78EA4B1C9D79D560" modified="2018-06-20" version="1">MSAPSPQCAALAAAISKKGVSYGQIAAQLGKPEQHVIDIVTGAVKPTTAEFDALAKVLDIKEPILSKEVVVAAKVGDGSVLESLLPVKVSDLVKSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGW3</accession>
    <name>A0A2R6NGW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v12480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGW3"/>
    <dbReference type="STRING" id="98765.A0A2R6NGW3"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12316">
        <property type="entry name" value="RRM3_RBM19_RRM2_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="245"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="430"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="547"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="650"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR71627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="771" mass="84881" checksum="A7DF53C77F7F7465" modified="2018-06-20" version="1">MSRLIVKNLPAYLTQAGLRDHFESKDGPGGTLTDVKVVLKPDGHSRRFGFIGFKTDLEAQKAQKWFDRTFIHSSRISVTTVEDAKDAPAPRPNKRPRLGESPESTKEATKTNPPTRKPGKSEAQLEEYLQVMQPRSKKGPSWKDDDTTLPPSSGAPSTKPKSNPEASADVSKMDEDEDKGSGPEEGRSDMEWLQRHMKGSVTVTDADKDYEQSDEEETPVRVKPMDVVQQPSSEDEANSTILLTGRLFLRNLAFTSTEEEIRELFGSFGNVSQVHIPLDPSTKSPKGLAYVTFSDPSNAVSAYLALDKKSFQGRLLHILPAIDRKGNVVVEEGVGKRKTVKEERDAKRKTMAGKEFNWSMLYMNSDAVVSSIADRMNVPKADILNPESDNAAVKLALAETHVIQETKSFLETNGVVLSSLSGQRIARNDTTILVKNIPYGTSADQIRELFEPHGQLQRVLVPPAGTMAVVEFAHPDEGRQAFRAVAYRRLGNSIIYLEKGPVGMFVEGDVSPTAGPSKGPVTAIGVQPVTIADEHADTEEVPLSAGSTLFVKNLSFATTSDRFTQAFRNLPDFAFARVQTKPDPKRPAHENARLSMGYGFLGFKTSEAAKKAIKSLQGYVLDGHALVVKFAGRGAEETDAGDEKSKSRTTKMIVKNVPFEVTKKDIRELFGSHGQLKSVRLPKKFDHRSRGFAFLEFVTRHEAENAYAALKHTHLLGRHLVLQWAEEDSNVDIDELRKKAGLGFGGGKEMPGRKRKLDMGDGDGDIVDNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH87</accession>
    <name>A0A2R6NH87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v12738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001286">
        <property type="protein sequence ID" value="PSR71362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH87"/>
    <dbReference type="STRING" id="98765.A0A2R6NH87"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR71362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="544" mass="59167" checksum="38009B5C0886185C" modified="2018-06-20" version="1">MASYAVDKASTSSDSGKGHASGYTLDEKRRAALAEVDNAKFSFFHLKVCLVAGVGFFTDAYDIFAINIASTMLGYVYGKGQKLSTNQDLGVKVATPIGTLFGQLLFGWLADLVGRKRMYGVELMIIIVATFGQAVSGEAHAVNVIGVLIVWRGLMGIGIGGDYPLSAVISSEFAATHIRGRLMTAVFANQGWGQFTAALVAFIIVAAYKKSLLADDPAVLPHVDQMWRILIGLGCIPGVLALYFRLTIPETPRFTMDIERNVQQAAQDVDNFLTSGTFYVDPDAAIERVQAPKATRRDFFQYYSHWENLKVLIGCSYSWFALDIAFYGLGLNSSIILNAIGFGNPPKTLKGTMAVYVNLKNICLGNLILSVAGLIPGYWASFLVIDRWGRKPIQFMGFTMLTILFCCMGFGYDRLIATPAASKAFVFLYCLANFFQNFGPNTTTFIVPGEAFPTRYRSTSHGISAASGKLGAVIAQVGFARLKDIGGSNAFVGHILEIFAFFMLTGIFSTMLIPETNQKTLEDLSNEDQEGFIQGPAQPKQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHD1</accession>
    <name>A0A2R6NHD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHD1"/>
    <dbReference type="STRING" id="98765.A0A2R6NHD1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12609" checksum="E0CAAF63A374EED8" modified="2018-06-20" version="1">MAVYSLGPLIGPAVGPIAGGFIGETIGYKYIFVVISALCGVAAVLGIPFLRETYSPVIRLRLAQKSSDPEKTAKMHPHLVQNHGSALHLIWVNLARPFILLTRSFVCFILSLYMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHR5</accession>
    <name>A0A2R6NHR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001233">
        <property type="protein sequence ID" value="PSR71910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHR5"/>
    <dbReference type="STRING" id="98765.A0A2R6NHR5"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="341" mass="37128" checksum="39F8B706DEB09C14" modified="2018-06-20" version="1">MAPEFSKAALGLYPIVPLYAVDCDNQKNKQLCAEQGVQGFPTVKLFPRGKTVKPLIFDGAERSATAFFYWGSRNIPHGVKKLYQFGDIPGWIQENTDKPRALLLNNGKHIPLLWQAIGNKYKDHIKFAIHRDRQGRSSVAMGFEAGEKGSAKVLIYPAGSTDYVRYEGIQKFDSLSKFLDTVVDGTADLRISNAEAAKEEFVPDDTELEIERKQEAQRMALAHGGFSDMIDFEAAILAGHGSDFHDKNGYTGVMGGGLPKKDAKSEDPILKTEQETQEQSAESPKMAKTGDGQQEVFEAPTDAGHPRTPAASATPAPSSEAGTFIPHAEGAQGTARAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJA4</accession>
    <name>A0A2R6NJA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001177">
        <property type="protein sequence ID" value="PSR72436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJA4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="6226" checksum="CA67E13D46B30C63" modified="2018-06-20" version="1">MNNQVVEVHLRRHIVVFSWCMVRIYSYVTKAGMQLTYEAHVYQGITAILPDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK06</accession>
    <name>A0A2R6NK06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v11488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001148">
        <property type="protein sequence ID" value="PSR72641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK06"/>
    <dbReference type="STRING" id="98765.A0A2R6NK06"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="30"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="606"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR72641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="687" mass="76286" checksum="FE8952E23E37BE02" modified="2018-06-20" version="1">MATTTLGSEIVSVINKLQDVFSAVGSSASQIDLPQICVLGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLINRPATAPQTNGEKKDPKLGNDAHANENEWGEFLHLPGQKFYDFNKIREEIVRDTEAKTGRNAGISPQPINLRIYSPNVLTLTLVDLPGLTKVPVGDQPRDIEKQIRDMLTKYITKPACIILAVTPANTDLANSDGLKMAREVDPEGQRTIGVLTKIDLMDAGTDVVDILAGRVIPLRLGYVPVVNRGQRDIDSNKPISAALDYEREFFENHPSYKGKAQYCGTPFLARKLNMILMHHIRATLPDIKARITQQLQKFNTELQTLGGPTAESSSGVVLSVITDFCSEFRTTIDGSTNDLSLNELSGGARISFVFHELYNQGIKTIDPFDQVKDGDIRVILYNSSGSTPSLFVDTTAFEVIVKQQIKRLEEPSVKCCQLVYDELIRILGQILAKIQAFRRFPALRERFNSVVVNFFKTSMNPTTKLVTDMVAMQACYVNTTHPDFLNGHKALAIVNERMNANKPPAPAETKGAKLNNGRDLDVDSKKEEPSFFGSFFSAAKNAPKKKGAAIMDSPPPIIRPQAALNDRETMETEVIKLLIHSYFNIVKREMIDMVPKAITLTLVNHSKENLQRELIQELYKAEVLDDLLKESEFVVNRRREVVAMVQALNKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKM2</accession>
    <name>A0A2R6NKM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001124">
        <property type="protein sequence ID" value="PSR72929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKM2"/>
    <dbReference type="STRING" id="98765.A0A2R6NKM2"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30240" checksum="4BBAA11C1D5BAFBE" modified="2018-06-20" version="1">MTHSEQRIKPNVHPEGDVHQGKFSAIPHPLPEDHHARPQFKPIPDTGWKGQPSVPSQSGGSDEVDFLNKPPYFWKSEGSAGAETFLLNFMVTQSTQSTVTVDSVNICTVHRSSGRLYSPRWVPLRLLFSTLRILSKTAQTSVRMIKNVDDSLHFFSTEKKKGEHCVPCKVSCNVCRAPIFDEGRNAVLAYPGSFKFKDHKVPMDFQPTAHIFYAQRVMDVPDGIPKWSAHKGESELIEEMSEDQGTMPKYKGKPIPDDEKYQDASKGSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM26</accession>
    <name>A0A2R6NM26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001084">
        <property type="protein sequence ID" value="PSR73329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM26"/>
    <dbReference type="STRING" id="98765.A0A2R6NM26"/>
    <dbReference type="OrthoDB" id="2786002at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="172"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="402" mass="44599" checksum="530F7F75D05F24CE" modified="2018-06-20" version="1">MSVTTPYLRSFSISRSNYNTLGLGLTQGEPLPTKKYGASRNGKLELMERSGRSELKIGSGGDHSRCIASQRAHASRRMQAEGAVNRLFDSAPFCMDGDSPRNLDRKNSGYQQDYPQAGPSREGIRPIQRYDGGARSTSSTINDYRGMESRSSPLRNLPKRPPGVGPAGSYCTVIKVSGLPDTITKEELKEAFGKFGDVRIVRLSVDRKGMFDNSAHVAFYTVDDAQDAADSQDPIILHGSSLRWHLDFHFVKGESLEPTPMLFMLNVPPDTPKDVIRAKFRDVTEVWDVIYNDQGKNYVHINVPSAEDAKKVMDRHRQRPYSFGSGSLKIAYTNPSSTIGRTISQYRHVSKSGDDASYKSFKRRGPPSASIFVAGFPAGTSQAHIRHLFERFAEVKAIRIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNC0</accession>
    <name>A0A2R6NNC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNC0"/>
    <dbReference type="STRING" id="98765.A0A2R6NNC0"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="121304" checksum="182FBDE0E9D5D37C" modified="2018-06-20" version="1">MSSVSKQTRRWCHCGVVCRVPREVSRTTYYQHRKLVLRNLPGDPHPRPAETGVPPASKRSRLEDNDTDAAEHDSESNTLPGLYCDQSEPSVVDNPTDVTLADAPSATQLEHPLLTVPPVPALLERPSLRVPSMPALSDEALDVGFDYEAWQAETDGTGDHALDDEATRAGLDLGNLADIDPQDSQSYAGNRTLPDDNNEQLPPELHIEDLRVSQAFINALQGASLDDEDLHPDVLDRLRNPPTDEYQLDDPTLHLSLEVFLGLDRASEAHYDLMCGAVLRSHGINMLSLYQVKRAVQDISGVRAVYDDMCINSCVAYTGPFANHDTCPTCAEHRYDQLKLAEKGTKIPRQRMLTNVIGPQLQAMWRTPAGARAMKYREECTRKMMEDAQFTVNGKSINVPVYSDYLHGSEYISAVARGDILDTDTVLMLSIDGAQLYRSKQSDCWIYIWVNYNRAPDNRYKMSSVSIGGVIPGPKKPGNMESFLFTGLHHVLALINEGLVIWDSDALRKFTSRLFLAFLTADGPGMSSINGLVGHSGAQHCRLYCGMKGRLKPGSGIYYPVCLRPNHYNQAGSAHPDVDIFQLSMQDHATAVESYNNNLSRVKESHNGNQYRLRRLETGIVKPTILSAFPPHSIFPIPGCFPADLMHLAALNIPDLLISLWRASITCESGDSRDSWDWAVLRDSQVWQEHGREVAATAPYLPSSFDRPPRNPAEKINSGYKAMEFLTYLFVLGPGLFYGLLPTKYYNHFCMLVRAFRIVHQQNIPQAALAEAHKLFIKFIMQFEDFYYQRKVSRMHFCRPALHGLAHICPETTRAGPYAIFTQWTMERGIGDLGAQIRQPSNPFANLAQRGLRRCQVNAIKSIIPGLGGQKAHLPRGAVDVGNNYVLLTASERYAHTVPNADAQALRIFINASGAKVDESWLRQPRLSKWARLQLPNGQVARSYWQEGSKPLVNNRITRNIKIDIQGKTEFAEVQYYFKVALQPNTPEVAFAMVSVYSAPDADLLASSCNTLWSCKYQGNDNLQVVSVKQIRSVVAMVPHPRVADNALAHKLQGRVYVGEQMGLDVMLMAGIVDNPTGAEVETVTEVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNT2</accession>
    <name>A0A2R6NNT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNT2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015302260" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8080" checksum="016C65816C094217" modified="2018-06-20" version="1">MSSSLFTTSILVIALAITLANARSSHSSGFGPPLRHNYTFEVYLTDTNSFLQWADIFSTDRNWLLLAGSQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPA7</accession>
    <name>A0A2R6NPA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001005">
        <property type="protein sequence ID" value="PSR74289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPA7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="251" mass="28085" checksum="1F4579ACE5626871" modified="2018-06-20" version="1">MLFDCPIWMMREPDFTKEWLTTTATPKQFIRAIASFLSAHPLAGSFELADAYKASEEENQTLGTDAGPLRQALLQQLKVSVRRWRLWQGNEPIPEPNNEMPKEKAVREARNYKRWDALIVLEFPEGANQRDALAMTQTQSQLRVASPEASPLAAQAANPKQAPPASPIRRTPNPESPPGQIDLEPPPPGQSDIPLPKGTLTTNNVCAIDEWSQTEHNMHVQVGRDLANIEADQVAAIRNYMEYSPQLRAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPF4</accession>
    <name>A0A2R6NPF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v9883</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000990">
        <property type="protein sequence ID" value="PSR74375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPF4"/>
    <dbReference type="STRING" id="98765.A0A2R6NPF4"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF330">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="211"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR74375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="621" mass="69154" checksum="671319ABA7EB2EA2" modified="2018-06-20" version="1">MVLAALHIFSRQYTQGDPEKAHAQSGGTIQDDGQAVTDDDSDEVHDRDRLGEPSRKTRHRPATFDSASSTSTGWISRTKSYIFPSDENEATLEQFIPNYRWTPIISGVVIPFSILLEIPGLTEHWYIRTEANQVVETKNLINIVAITVFGVEHRFDDGFTYGQSFWITLCSTIASTITNVTLILDYVRTPEFARSGSGLTRKQRALVIIVIVLMVYIALGALINSLIQGLDFIDGLYFTVVTIETIGFGDITPKSTGARVFTCIYMAFGILNVGIAVAMTRETVLEGLELGYRRRLRNLRLRRREARRFRRWEARWSRAVQWRLREAGQPIWVPDEYLPNEEVHFIGLSGPGEGAGEVHWLRKWLESFGLKRHRSNKGARIFPHGKHLNIDALTPQQLEAAALEAGVPLELFLSPPSTKRASDEDRGPTNSNGPGNSRLRAPPHGQQSSTNGWPTSPQTPTHAQMGRMAAMVTKFGMALTGTHVHMIGHAAETHPSQQRQEEAQHDAEPKHGNAVFFDENDPESNGDNGGSGEDVNEGDNEQHGSGSPQLPQIGTLTAEGSLHPDLPKWTKDLAHGKNEQSGILYEDFKAEMESEEKKAYYAKASCLVVTKFLFQILIHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ73</accession>
    <name>A0A2R6NQ73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000970">
        <property type="protein sequence ID" value="PSR74667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ73"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="7652" checksum="D6B39E11FDAA1244" modified="2018-06-20" version="1">MPASLPASLPACLPACLPIGAARRGAGRRGAARRGAARGGAARRGAGRRGVARSSSPAKGQEWEGEARVFTNTTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQS2</accession>
    <name>A0A2R6NQS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2262</name>
        <name evidence="3" type="ORF">PHLCEN_2v9488</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000949">
        <property type="protein sequence ID" value="PSR74873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MLYV02000209">
        <property type="protein sequence ID" value="PSS31970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQS2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS31970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="7997" checksum="219A2EF31E960E4D" modified="2018-06-20" version="1">MTRPGAGSNQELGAPLYATLLYPTLGARVIRTLPYPILAGLAFLYLPVGFAPALRPDQPQSTVSSKSRRIERTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSS5</accession>
    <name>A0A2R6NSS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000882">
        <property type="protein sequence ID" value="PSR75619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSS5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="124" mass="13976" checksum="BDB721B58C0A64AE" modified="2018-06-20" version="1">MGADLDHGPAEEPDVDEEAEDVDVDGGDVEVAASEDGSGGIVHEIQEWCKDSSNILSSYFKIRSGINEFQSPVVPFTVMSRYQEIRRRTFVNRSLYIRNVTLKFIACIFELTDIDYRKNKVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSX3</accession>
    <name>A0A2R6NSX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v8700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSX3"/>
    <dbReference type="STRING" id="98765.A0A2R6NSX3"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR76038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="236" mass="25811" checksum="5BEB7A65F14AF44A" modified="2018-06-20" version="1">MSQVDTTYTPSQPDVEEGIEYWSTQPASYDGVLELSTVPSAIRPLKTPPAHTRRTRALDVGAGVGRVTSDVLLHLVSDVVLMEPVEGFVNEAWKRGASSAEGILVEDSSHARWKGIQNKTKSVTVVQGTLQALDPLHPLADPTTKLLGRLGYEPAEEDLESGFDVIWCQWCLGHLSNVDLVAFFKRCRQGLRDPDNSIIVVKENLCHNAADGGPETVFDPSDSSLTRYFIPLVRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT47</accession>
    <name>A0A2R6NT47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v8600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000859">
        <property type="protein sequence ID" value="PSR76177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT47"/>
    <dbReference type="STRING" id="98765.A0A2R6NT47"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="109"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR76177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="263" mass="29535" checksum="40517BD8F9FCDFD0" modified="2018-06-20" version="1">MSLLRNAIVRSVNGAQRPSHSPLRLTRLSAPLLPFNRTYASKNKKKESRADNVTSDQKKGGKGGGITTDQLIPGSQRFVTSPEYISTEKKMKTAIDYYRKEVAALEMRASGRVTPAVLSPVRVMLPDHRGGDGKGVRLEEIATVGVREGTTLLITVFEEHTLKYVEKGIYDAEIPGIVPHRQDMRTIKIPFPKPTVEARQALYAAAHRFSEDIRVQIRKARDVVVKPFKKHEPEYEEFHKLGEKYLSEVDKILADMKKVTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NT62</accession>
    <name>A0A2R6NT62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NT62"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="91" mass="9429" checksum="DE2D2023670D2900" modified="2018-06-20" version="1">MSAPSLSPPPPSLLLIVTCSLPPHVSVRTHSPPPTRSVPASSEHGTQQAQITHPDPRASALTALALSRHRPPSSAATANADDEQPGWATCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTF3</accession>
    <name>A0A2R6NTF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000848">
        <property type="protein sequence ID" value="PSR76357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTF3"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="464"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="695" mass="75516" checksum="13893A3DCE48D10F" modified="2018-06-20" version="1">MATRQSLPRAKANTRPAEKAGLLPTKRRTSEQVRADNEEKERRKAADLAAKAAAKNAKVSRIAELEEQMAVDDADEQLVRHTAPPPEPPRSRPRPRLRTGPQLTRTFAVSDLNGAYEDGRQPECTGVVVTNVHKVLAPSGASVTAGDGGYISGSEADNASVEEAVIRSPPKKKQKSAIREAVSAVRQDIQLGVKASITFDFRSQGNMDANIVVIDGRTKDWEPPSQKVDKPAQNSSVFIKTWASDVFTQAIRTPFNSRAGTARSSSAPSFTSSSAILASIPVYDSENDSGSNYNGFGNDEDEIIERIAALASPSKAGGIVGLVQPKAEEAEAQPAVRKSRPTTGIRVEPISELDEVQTVPLSTKTTTTRTTANTKARTAKATTTVATNTVATSTNVVATSTNATNAQLPAGVFGRWRSQFVPTYMIFVGGQRDPWNIDDPTAESAIKEAFTVVYPNVPYPQDSVAQQGMFGVLNQRIYEYRGGFGSTALMALHDYLGALPQLNCTDLQQAHLKQMLEKKAFLYEKFDMEMDRVTPYWGGLLRSPFIIQTFAHHFTFTEGAKNVPGFAELTPKGALALSAAAMERAFTLWAEGMIGFNKRGVPIVLPARNARTGKESKIQNAFAEQNWGDAIRLYARSVENLKSGSFAKIVEQAKAFANQTRLASKRHVPMVINCDLDDEMDDRGCLQDLSSDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTQ8</accession>
    <name>A0A2R6NTQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTQ8"/>
    <dbReference type="STRING" id="98765.A0A2R6NTQ8"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="13988" checksum="D2A81E562CF2BA8F" modified="2018-06-20" version="1">MTAGALTRGALGVVISGRCRDVAEHRSANFPVFARGHSTLGQSPFTRPSAVNVPVVIEPQGVTPGVEGAFPAVEVKPGDWVMADEDGVVCVPVGLLSQVVELSQKGRDVDAKCLEDIRAGSGVQEAFRRHRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTR5</accession>
    <name>A0A2R6NTR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000842">
        <property type="protein sequence ID" value="PSR76514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTR5"/>
    <dbReference type="STRING" id="98765.A0A2R6NTR5"/>
    <dbReference type="OrthoDB" id="2744015at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53609" checksum="B36D75D3AD08439A" modified="2018-06-20" version="1">MHRQYGTGHPEEKVLESEDISVPKATPSPQIVSCKMDLNFDILVLMMYFLPKKDVLSCMLTCRALYDSGLPFLGRDINFNDFISYSDTKPLTFQQQFQSFLSFIRVDPPWLAEGLLEIVEHGRLIQSLDLRLGRGGPSVFETHPRLSAAISSLTNLKYISLTVTGSRGYRMLKEMRSPLVAVNVNFMSYEDRWGTRTEPYVDPLPLLSHLSSSLKVLGISGVDIKSEHHIFPDMKELTIVDNAFDTIAPLIRAFPNIRRCQLTGTALDNPDAVEQLRAANLITQARVRWDKLEYLSGCPETIHSYAPCTQVLHLKISPLYAPESHRFLSPILLHTQPLCLEIFAVIRNVRELKEMVENLNLAVFATRTRFFKLVSRTGWIAACNRKKENHADLGFAIASQLILSCSSLRHIYIDLAGQLPGFWRVEPANVDAGVLPTLIEVPYGRASSIMRKQGFSPRLKTRKTLLVSHLEVFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU23</accession>
    <name>A0A2R6NU23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU23"/>
    <dbReference type="STRING" id="98765.A0A2R6NU23"/>
    <dbReference type="OrthoDB" id="3269223at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="301" mass="31986" checksum="A583CA028ACB2ECF" modified="2018-06-20" version="1">MDNSNGSGSSPVKKQEEMDDTKAPGKSDTKPVVRTLNRVPHIRQTQNVIQNTLAEIAAHLRMGSHFQTRSPSAYPPFAHQSPSVHSMGSPSMSTPTAGVHPPPLMVDTAHPATPGGSVGTPSHQMMTPGARQHVTNAYQSPPLSAAGHRPGDMHAPPHPGNLYAGQHGHPQAGPHGTTLPPFSSLETMGPPRGQPSNVSSMRYHPGDQHLHVQHRSNGPETASGSKRAAPTPSAVTSADSTDAEEEDGELPASGLVAPWEVLRGLADVAIERAAQVTSEFFNAYKFDGCRSGKRRRKRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU55</accession>
    <name>A0A2R6NU55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triacylglycerol lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU55"/>
    <dbReference type="STRING" id="98765.A0A2R6NU55"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43098" checksum="8D719946211BFBDF" modified="2018-06-20" version="1">MRLARTRPPSPRLSTPQATPKSRSILDRAIKSLSISLPMNGDSSSQSKSHKRENSQPALPVLRWFTGKQAAQPQLPSRIPTQSRPSTPLEYSDSPTSSSSHISALNDALCEDPRLAEAHSTEVHLPSRPEAARLPPSLRPWRPPNHLSELSRTALPTACLSPTSTAPSAPAYQTPYTDPFADPFTQSEHNPDMDIFFSPTPTPLSFPHTPVPAHLNRSPPMLSSSSRTSLETLRSIQERSLHTTPPSQRMNLASFPNPFGWFTSEDDAQRKENMDPLLKDSDKAQDTESQKKNIKQKYASPKNPVVFCHGLLGFDTVTLGLSIAPLQVAHWRGIKDALEMNGTEVLITRVPATSSPVDRAKVLEERINQAYPGRSVHLIGTSLFAALVGMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU91</accession>
    <name>A0A2R6NU91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000835">
        <property type="protein sequence ID" value="PSR76761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU91"/>
    <dbReference type="STRING" id="98765.A0A2R6NU91"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="99754" checksum="804ACBCA5E2DBC58" modified="2018-06-20" version="1">MYAVRQFTSPSFTCSRRFATLNLTKSLHKRNITFSSPRRVPESPSSAATTVEEQPHATESKGKQKESLESIENPDIIVEEDRLPFLQRPLGVKDRPTTVARSWREDMMDQETRIHHREKLVKAAGKGYYSDLNATRRHGGKTWIAPKVLIREDKALYFPDIAGTPLTGGDKVHTTDLLMGKVTILSILSSKISEAHSEILTKPTLEAYGGNPLLQTVEINLQENLLKSLLVSLFARNIRSNIPEEQWGRYLISSQNMDYVRDDLGFANRHVGYVYLIDKACRIRWAACADPMPEEVDALQAYWELFKRYPRRLFNPLKRDASSKKLDIAPHATRSLINKDPGYERDGRRPQAWRDELENIIAGDWLWEEGEIAGVERGQIGVALSSGSGSKTVYNVGKAKSASRSSARESLGVGVTNGTTAQEQLEHWGDSIPESKAIAHVAGYTILENIFILNGTGFLVTDSASSLPPLGSMASSAVNSILAPRGQDWRVLNRVTAQDILGTFGGRIRGTTWLTTEPADSQDPYTVFSLHRLHSYLASPHSYSKVSPSGLHILSPDSVNVGLGGSQSVTPPLRMWLPRVPTLSSPSLPPIGKDEKAHPPLREKSYTGSHPSLYKAVFPTVGILYAEDWKDYADMQIPFLLERVLLVDRGAAERGRSEWGEKWSDSSKYDSSNDELRKRQAVEDGLPVWAAPFVAFDISSGWFEPVRSALRSYLRLPAESTQKKRKPELTYVSMADEPQGSGPRIRDEDHPELLKGLHALKAEGILGEVHVVRGNGTRDVWEDRMTAISRSNIMLGAFGGNLADSVFMTPPSKTEAPQPDSAPVLMEFFPSGTFLRDQEYAVRSVGLRYTAWWGERKFKGISLPQVMGPRSGQNLYVGIDVPAVLEEIRAEAKRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU94</accession>
    <name>A0A2R6NU94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000846">
        <property type="protein sequence ID" value="PSR76420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU94"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="366" mass="40594" checksum="315FBEB90DDE7A18" modified="2018-06-20" version="1">MLGETCTLDENGSMRPAHGAPDASGEFHVRNDYRSIHIGVKAKLGNEFSAIYLSERPFYTGKVDLTPVEKVLVWFDMSSQTGTMLVKAITDTIEINFTGSAAPQTVKYASDPQTPGKGAWTRAEQIVLSSTYHIDTDTFSLEQPSMSCLAKLAADIVDSQKDLQLSKVSVSALVEFHEPGAAQKFAQYALEHQPDGVRTWEFTHSGHIVESKLKAQKDQEDDLAVRFLQDAYLGVLYSFQGSKYKRLGFDIHGRNSTLPGIAQDLRSTGTLLVEYRNKEKARQAAEGIADMSGYALQYEATVVKDTWVTMLFWPKFTTGDVDFDRNAIVDPLATALFGGEGEPAKYPPRSPKTREAMMTLLKWLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUJ1</accession>
    <name>A0A2R6NUJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v8136</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="MLYV02000825">
        <property type="protein sequence ID" value="PSR76912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NUJ1"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="47"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="233"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSR76912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="471" mass="53932" checksum="83161E98547D7AC8" modified="2018-06-20" version="1">MEFLHQQLAQVQRHLAFVAVDPIDWKTYVQAFSWGVCLFESYLLLRQYPLYSKKTPPPVLADHFTQEVFDKSQTYGKDKAKFSLFAGLYKQAIDSAFLHYGIYAWAWEVGGNLISKFGYGSEYEITQSIAFCCVLFFVSSIPSLPLSIYQTFVLEERHGFNKTTLGLFMADMVKGWAIGLVIGAPFLSAFLYVFKWAGDRFVPWLMGFLLAFQISMVIIYPTIIQPLFNKLSPLEEGELRNRIESLASKLKFPLTHLYEIDGSKRSSHSNAYFFGLPWSKHIVIFDTLIKESKPEEVEAVLAHELGHWYYMHPTKLLLVSQVHIFSILALFPAFMYAPPVLRSFDFPKHIAAQPPTIIAFLMFQMILTPLEAIVGIGMNAVSRRFEYQADQFACELGEKVKLVNPTEKTADMDDMGDRLGRALIQLHVKNLSTVWVDWLLVVFFLSFKWNLVRLITISQILCIPSFSPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUW0</accession>
    <name>A0A2R6NUW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000809">
        <property type="protein sequence ID" value="PSR77189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUW0"/>
    <dbReference type="STRING" id="98765.A0A2R6NUW0"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15919" checksum="918B28EEB7652811" modified="2018-06-20" version="1">MSTRSDSTPTNLKPTYLYKLIPHTAPPPSPLPLSLPTSALDRSSGFVHLSTAAQVPGTLRFFFSDHPHVYLARIPYERVEGDVRWEDPKAEVCGVRGGEGVFPHLYNERVALGAGEIESVVRWESGVDGWEEAVRKGQDWLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV33</accession>
    <name>A0A2R6NV33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PHLCEN_2v7948</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NV33"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="354"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="675"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="802"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1434"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1677"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="675"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="815"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1091"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1438"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1677"/>
            <end position="1701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PSR77347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2131" mass="232884" checksum="E6DFF6522E95F7D3" modified="2018-06-20" version="1">MSWWPSSWIPTLPAFDFSLPTSIQKRFISFALRQALGHLLKPGQLDIQQVDSQIGSGFVQVRDVELDNDAINSLITGLPIQIHDGSVGKVTVRIPWPNPLTSEIGLSLESLHLTFVVTPTVSKDPRAIPNLAASVASVAESFIHDELDSQEEASLRDSFHPDLPGGLDPFITDDEMRNDTDPPGVSIFASLVEKFLSRFCFDASDIKFTFVYPGHSSFTINIPEVLYRTEVAETESGPVPGSSQASEPQAGVTRTVTISGLTVSTRCLRPPSPQPLSSSSLSTHSFTLRRAPSENQSSVTASPLYSPALSDSSELDDDTRMLMSQSLVTLPPRPHSPASSVASSMYESAISMASSARRDEVMPPPSSSPTAPLFDETGRTTPTFPSSTQPRAVPRSKLGISTKEIEDETLLSAGTEPIVLRLLTPPPVRRTMPPQLSPSPASTNPTSESLKTKVRSIREEGPAVIKVEVTLGYVAFALRARHIRNLLDMAQLWASHSPAADAALTEESSYGSRRSLFDTMDASLRIRGVACILLPSNGTPQSTESLTEYFKRPVVPPRLPHGFVRVYLDFINVSCSIRQTPQPPAPRTGRPIRSGSTVEMSIMLSDLSAFAFLSDLDGNPQLSAIPILITDPSLPLQYSLVYSHPNLPQSELPSALPIFDVADWTDNVLRTSSAKLSSWRTKAPQGRTSSTAGSPMTSPSNLGSTPPIHHKSSVSPSVSSPSGTSAIASGSQSAISVKFTMTSAYPIGKTSRSRSKAPESSVEASVDVAPLHVFVDLKSALGGSQASSVSEAILFLDELSSGDAGAGLPSNDELTGTEDFEDDEGEDDEDTPPGTPHSTAFNLRNQEKEQERERKRLERLVLEDLNLEFDYRPTPQEKMVPSVSKVRSWKKKNRHQARRENKLELCIKLPMARIEIRGAPPIPFAPRSGAVVLDIHNLCIFPLGMPQGSREPTARFAESPEATVSQHPDTVVLSAHWERLVLAYAIVGESRASSILSLGQIHSGTEEAVRSDLGIGRQTRNNAPFHLWPHVVVSRSSSKLSTSALKLTTLALSIDVPSVFVKLSKPELDGLQFWADDLSQMIERSTNARLSDTDTERGDSRDPSLIGSRFFVKTRPKRGSGTDSSSVVSAQKPGANNETVIKVIVQQAGLRLMLPRHTQNASTRPFDLIASDIDVLVELNPEGKEETVLTLGVRDFKVVETPASGLPVTFIGSTVPRSTFTTLQSLLKVRFTSLVVPGTIAKESRVKVTLCGITGSIHPDFAWLSELASFAKAPPGAFESVVPSEKTKLSIRIVDCSIKTLAPTHRGAFVLHVGDLDFSTVIIGNSPETSLQLGVQGTSIFFVDDVDNVSDDILPMDHLSGLSRRSQASGGVWKAAGYALLMQLAELDLRFHKRHEANVPSIAVNIDRTTVRLHLCADTAGALGAFISDFASSFSGSPDEKPTTSRTPGREPTELTTSYAPRSLIASLDEHAFRRRIPEVGPAPDFINDDLPSNLDYLDDSFSATAGLRELPSDDELDEFGSDDHSSEILVQNDQPGVIFKYGGETIRLLNSEGLHLVDNYFETLPPDAADESAQYGDTALKIRAHNCDITVFLYNGYDWERTRRIIAEEAKEMRRRLAKIRQLVASGQTPDPSVEETNTLLFNSVYLGLEHNLDELEPADLIAAIDEELNEDLETASQSSWQSFRPKQTAPSSKPGTLSKHSLKKLTRFKGPCIEFRLEQIDAEIDNFQIHPSLASRTLVTVRDIEILDHMKTSTWSKFLTSLRTDSRGNIRETGSNMVRVELRKVYPVHGNPTEEARLRAKILPLRLHVDQDALDFMKKFFSFKDPEAVKQPDANPADEIFFQHVEVFPVDIKLDYKPRRVDYRALRDGRTIELMNFFHFDGSEMTLRHITLTGITGWAKMGDLLNDLWTPDVKATQLVEVISGVAPIRSVVNVGSGVADLVLLPIAQYKKDGRVVRGLQKGTTAFVKSTATEAVKLGARLATGTQVILEQAEHVIGGQFKDSITAEALQISPSNADWDERLLDDTDPDDLISRYADQPTNVKEGVKSAYKSLRRNLNSAAQTILAVPMEVYERSGNEGAVRAVVRAVPIAVLRPMIGASEAVSQTLLGLHNTLDPNVRMDNEAKYKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV64</accession>
    <name>A0A2R6NV64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000824">
        <property type="protein sequence ID" value="PSR76930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV64"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="13041" checksum="E7587EECB638A5C8" modified="2018-06-20" version="1">MKQKAFYGSHHVMNTNLGSLSQISSVSSSTSEDLDSDSVRSVSRLVFLAFSLANRVRRTNAIRKDANKQLERKRGQRKCKRCILVVIPSRYSMTFTEQIVRVKIYLRRRTAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVF6</accession>
    <name>A0A2R6NVF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acetolactate synthase</fullName>
            <ecNumber evidence="12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PHLCEN_2v7762</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVF6"/>
    <dbReference type="STRING" id="98765.A0A2R6NVF6"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="105"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="305"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="512"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PSR77572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="699" mass="75544" checksum="A33304964FF2541F" modified="2018-06-20" version="1">MSLSAAKMRIHSAPKSSKPVAFTRSRSTAAAGASPSMVEAKSRVREHVRNISQTTARDAVAAPSIRPNPAPGFQQLPTKNNVPYPPPSLGPNPNEPLDHSFVGLSGGQIFHEMMVRHGVKHIFGYPGGAILPVFDAIYNSPQFEFVLPRHEQGAGHMAEGYARVSGKPGVVLVTSGPGATNVITPMQDALSDGIPLVVFTGQVATSLIGSDSFQEADIVGISRACTKWNVMVKDISELPRRINEAFKIATSGRPGPVLVDLPKDVTAGVLRNALPFKATTPGTPLGLPTNPLHSSSQTPTDLLMIKQAADMINQAKRPVIYAGNGVLSSPLGPKLLKQLAKDGNIPVTTTLQGLGAFDELDETHSLHMLGMHGSAYANLAMQQADVIIALGARFDDRVTGKVTAFAPAAKAAAAQGRGGIIHFEIQPKNINKIVDAQIPVMGDVIANLASLVPLIRSSPRSQWFNDIKGWKANYPFTYEKSKIGGLMKPQEVIEELDRQTAHRKEEIVLTTGVGQHQMWAAQHFRWRHPRTMITSGGLGTMGFGLPSAIGAKVGAPEKTVIDIDGDASFSMTAMELATASQFNIGVKVIVLNNEFQGMVQQWQDLFYDKRYAHTRMVNPDFIALAKSMRVHAIRCHNAEELPAKMKELLEYPEDKPVLLECLVTQTEHVFPMVPAGKALHEQLLHPNLRSAYEAAAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVM6</accession>
    <name>A0A2R6NVM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVM6"/>
    <dbReference type="STRING" id="98765.A0A2R6NVM6"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="279" mass="30097" checksum="396C9343D8DD9F5E" modified="2018-06-20" version="1">MSPGLPVVPTSAVDSAQATMMTPYHTHGNSPPTGYRGMPSSNREPPPPSNTVPLPALPSSPLAQHHSPAGYHGNVRPLSSIPSRYASSSRAISTSPTLTSSSRLNDTRAPISRRASLSLAAITTPFTPDSAPYGNQSKNHRAQTLPQLGGRLRQALAFTGPAQGIRRRAFQCTLTTEIGQVAQTEDLFPSLRHLLLSQGMWVTSIKRTLHRHCLRRHMSLAHLATAIMVVLLESLLRKKFIRDPLTDSLSLCKSIADGKIAPCAASGRAARWISNRVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVP9</accession>
    <name>A0A2R6NVP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000785">
        <property type="protein sequence ID" value="PSR77675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVP9"/>
    <dbReference type="STRING" id="98765.A0A2R6NVP9"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF131">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="686"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR77675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="783" mass="87791" checksum="BD03D2B84634E1D0" modified="2018-06-20" version="1">MNKKALEEVPPRRVNNLDLMLGDFKFGPATINVPRDAGTCTRCPMELRISSSDRPWQCQISIRWEFTRDGTRNEQVKEEKFGKTITDKREVEIALRRAQAAILNPEVTPSKFATNSLEQLEWRQLPDRLLFSKNAVCLNLSGPGLTDIAFIDLPGLIQNAELETVTFVEDLVRSHIEGNCLILVTLPMSDDIENSRAARMAQQVDPTGIRTIGVLTKPDTLTKGAVKMKNLWLDVVEGRRYSLTHGYYCTRQPDDAERSNGITTGEAREAELNFFKKTAPWSGSAHHDRFGTDNLLADLSRLLLKMINQSLPKLQLEVSRQLTACTDKIAQLPPPITKEPSKYVFKKIAAFCREVQHYVDGDGGACQLVQDTRRVYHELKRNIRGSEPPFIPFADAAEAGSTDYTSRQLIWSEEEDEVVNINDYVVRRDDGFSRFIYLKDIRKHILDSLGRELPGNIPYSAKISLMATCRSSWENHSRRCFDTVVDTFDETLGTIIDVNFSKHMLFRAHILSMTKEFLDSIKESAWSHITGLLANEMAPFTQNGHYYQETKSKYLARYKDIKLGKLNIPQKPVHKRLKMTSGGVPDDSGVAQDNSLPSSSSKTGSSSSSSESSDSESPTAQTATNKPKTPLTSGRKRKAPKGKRKQCQTTPAKGKSTALPQTISSDELKAALVTLSVVVGRKVELSDLAKLNPVDFYEQELELMAERVIDLIPMAIDRSFLKTFAESLQEFLIEKLGLGTPNAQVRCASYLAEDAGTATTREELKAKKKRLEDVQEQLFNFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWJ9</accession>
    <name>A0A2R6NWJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000744">
        <property type="protein sequence ID" value="PSR78405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWJ9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="137" mass="15170" checksum="0BEFD600F0A73784" modified="2018-06-20" version="1">MSPRSVQNGTTAAGLVRCLWTSTSLLWTSLTPSPSAYVDHDDKSWWYDQACMSEGETESNDAKSQTGSDDGQALDECQDNTRTDKKWEGPDYDEDLNNPETSENEKGIRGGSRADALKRLRACSRRLVCRATSGTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWR8</accession>
    <name>A0A2R6NWR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000746">
        <property type="protein sequence ID" value="PSR78378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWR8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="239" mass="26673" checksum="7B2FEC9D5CC31544" modified="2018-06-20" version="1" fragment="single">NIETTVYTVITPIHELMIKCEPEAEQLPVSIMDTGFPKDAVPPSGWTLAHAAETITELQDKIAELQDELHSYRHRARVKDKLIKQLEAQLSEALSSAACYRSDWAQSEVRCWAMEACLHAERLEVPPEPQSQWPLWKQSPERRREQSVIVLTPLPLPSPSLNPSPSRKPSLLQSPSPACKRQRFAPNDDTAVGQTGNGGTAGEDIEDAEETQSTPPCESQHDMLWRIISAGAPSYHHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWZ2</accession>
    <name>A0A2R6NWZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000726">
        <property type="protein sequence ID" value="PSR78749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NWZ2"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR78749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="411" mass="45273" checksum="E6D58249D7889EED" modified="2018-06-20" version="1">MAQPASTQPPAANGAATNIITALGAAFKSQTGDPLPGEKIAQLLLQNMSQLGELCKQGKLNQQQIMQLKEYADRHKGSAIQAPTANTSAFKTTNPSPFLSQTPTNESAYPISQTPPAVTTGPLQWQQGQQGRPTLTGGVPSGRISGTPAQIARSTDDTNALALDETRTRRKNSPGDQSMRRSIQDLVSSIDPNVKIEPDVEDLLLDIADEFIDSVTNFGCRLAKHRGGDTLEVRDLQLHLGPWSPFKTSRKFYPLTKLRWVWSDAMARLIKHQGLSIPAIDVDFVDFKAFSSSQLEARVVHASKFHDNWYSQHPKARRVVRFTADPPEVFQSSETQESCSVKQVLFLTGRNGEFLVTLAGGMITCWEVPLDGSRAYRVADWTANKDIQQVVANQDPEHCVDLAFWAYESRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX41</accession>
    <name>A0A2R6NX41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000713">
        <property type="protein sequence ID" value="PSR78944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX41"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="60"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR78944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="920" mass="102868" checksum="3A68BD4038473B6D" modified="2018-06-20" version="1">MGPTTSDKSQRVDLTTASVSTSFASGQQAANESTPAEVAEKPTCGCCSHSKIPTEKSDGWKVLLEAMEQCDQKNLDRWKAEMDNLLIFAGLLSAVVTAFTVESYQWLRDDPAATSVILLAQISDKMTSFSIAPGFINSTDPNPRPIDTSSFDIPDAVKINMLWILSLTFSLIAAFLALAVQQWLRHIPVPEDMTIRQSARLRQFRQEGLGHWRVPMLVSFLPILVQVAVILFLVGLIYLLRPLNHDIGLAFTVVAGSLLSSFAITAFLPFYYRDCPYKSSFFPTILSIVQPIAKFIVYIIFSIAYYGAMLIMIAIYLGVYVVVGTAFASLCVAVLALYLALLVSYPVLYILTVVIPVLVACVMACVVCIWGCIPCISICCPCIPALLVVLVSPFTACFQIVLGAILVVMEPIITFITENFGSLSTSVGGSLVTSLCEALRKPLFILQGVFRLFTKFNDWARRLLPRISNEGGNETWWSRLREMFQWFQEEWKNKQEMVNNKFGDPEKLWLNLELKKMMSRPNVWDESVLALAPMAVARSESSFNAVKECLKDLGLAGPKALCAFKWAAHHLGVVSESISDDMCDYSEFSGINPKLLAKVDTIFAERYRDILWEVLPMDGHEFFSEGDRDILLGIMILLMETTKFRHNEPDYPKFVQDYMDLLMKILRAQAGQLPNSHDAQLYGRMPTALFYEGCVRHKHSFKDDDAMQAVKWAHQQLTTVHGKRTLSLLELAFGSSAIALIAMTQSKNETFVIESCQQLIPALKAYLRLNAQFIRSQASECEEEKKSQYVRLVFQHAMSSICDSLSKLARSHFNSDIRKNDSQHKVDLHGDSEAIRSILKDMLQEQKPFNDVLWEVKFPEGVPVPLQVTSAPPNPQTSRPLEKKPVEAPDAGSEEKLPSTEGNDSDSKEIEDLGIATLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXA9</accession>
    <name>A0A2R6NXA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXA9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="9123" checksum="999B6F28F012222E" modified="2018-06-20" version="1">MGYTNGDCPCLQIRQVNGEILNQPPAGYRARLRVESTVEEDRAQWPLGRIVTEITEVDRGALRDSDDDGDLYKIGRGFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXE2</accession>
    <name>A0A2R6NXE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000708">
        <property type="protein sequence ID" value="PSR79136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXE2"/>
    <dbReference type="OrthoDB" id="2803003at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="502" mass="54852" checksum="177431F42E129092" modified="2018-06-20" version="1">MPVTTRTANTEAHPGRPVIAGQRKRRTKAEMQAAREAEILAQAAKNNDERTRKAVIERLAYLEAQAASTSKAKLAATALPPTPSSLVVKGAGTSRGKGTANKVAASMKGSSESGKANLQDVNQSMKKVPKSNDKLTRQNIEIIRAALETPTPRGRGPNEVSMLMPLTTSDESVGSPAGKRKANDRQTTNASNKKAKPANAQTSGFRDGYIGSSAIHTDSSKGAANAKGKAIQVIRAASSSESDPIEDDDEDIAMGEAYFEEGASEGEKEEGGEIEVIDVDAFPSSSEDGDVVPFGDGAEERQTKPFQREVLSVEVGEDTTRSYGPPWGRNPAPKEKWNKFDLPIAPKDHTQFSEEFLHRCIRWVGNQRVTFNTNSVNILAAMQVSWDAVFSLDYPLRITRHTPVYDITMQKVYQWRNTLGTLAYDCVDEYFLDHKNTFKTDDERAAHVDELLKMGGKLPFLYARIRTNETSGKREGIGAFQGPIVLKVFAAHLKALEAIDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ03</accession>
    <name>A0A2R6NZ03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ03"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ03"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR80762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="201" mass="22108" checksum="4639B86425DD8AE8" modified="2018-06-20" version="1" fragment="single">MAEDEFDSLPDFYEGIDFDSVPELSSTHNDEEEDASTPSSHYSFDELDDSALAEIDAIEMRLTTETADNYTPAAQQSACQPSSSSSNTTDTLPNRKRTPFTTELKPHHPAKRPHADDLSPRKTPRRLLTVPSESGEEDSCIGEGQQLEKPCVDSGLKKVLEGFEDEMTCPICFDIFAHAYLGNPCGHSFCGGCGHNWISNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ73</accession>
    <name>A0A2R6NZ73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000626">
        <property type="protein sequence ID" value="PSR81095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ73"/>
    <dbReference type="OrthoDB" id="2755060at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34399" checksum="10E5E785ABF1FEAF" modified="2018-06-20" version="1">MSADAGNCYNHLRVLAIDIAFFQHERYKRMFLNVLRRAHKLEDLSVLDSDLLTTDTRFPTIIAKLTSLKVFTLAHYGSENFEPANMLSLMRSKLVKATIDFCEFEDPIDRLANSASSLEELDAVHVYFEREDVQYPKMKTLSLEFWRVADIGPLIHAYPNLCTLDIQGYSANESYLVNAVVDRATNQEFQLQKSWKTLDSVHANIVELYALAINCKIHSLNVADGLYNLQHIEMLCATLADCRPSILHIHCMGFKTERFPDIPRSIPSELVEVDLQVNLEELSTSDELDRFLVSMSSVLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZP0</accession>
    <name>A0A2R6NZP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000616">
        <property type="protein sequence ID" value="PSR81503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZP0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="8818" checksum="1700B57D429F14BD" modified="2018-06-20" version="1">MTEHPRMHIERTSLPKPFPTCGVSVRFSTGDKHSPYGLSMASENPGSQAIYEQPRAFPAKGSRDDAGLFHHVVTYSGSVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZX3</accession>
    <name>A0A2R6NZX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PHLCEN_2v6269</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZX3"/>
    <dbReference type="STRING" id="98765.A0A2R6NZX3"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="441"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="22">
        <location>
            <begin position="743"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="285"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PSR81760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="899" mass="99202" checksum="8B00040F6B77212A" modified="2018-06-20" version="1">MSFKTNLNSQDPDLAPNAHVIWSQGFTNPVVAVFDVIRSPTRPHPFVLLQPHIGLQDLLPNVDLVSAAKENRLPNLESAYIGLIEETGSLFAMSPDRYPLIVFSDSNFEDDYMREVGRSIDPPPGSFGFVNDRDFPVDVDSITRAMKRKRLKEMCKNGAKDKRCLTGVRRLESSRLSRLLDGAATVPYPPYHYNNAIPQSSDSNVLPGTGNASMTPPAGLPSPRVDNTPRDKMGKSPQALSAYALATLALLVTIIWFFKKHIHWRASTPVAASDNGDAALKTKLETSTADSPQSETAAIDTAAKASAENDITQPITDPVMSPPASMKKVSFGDDAKVVSVSGQDQDDIGDNGGDAEDSDGDAPATPGKRKGIRRRRGKKKKGAIAVNGADDVAENIKDLAKNLEDEVPKLPDDGGFVHIVSPSAIVVSPPPTPTPAAPSLIVSDTILGFGSHGTVVFKGSLQGRAVAVKRLLQDFVTLALREVNILQESDDHPNVIRYYYQEAQANFLYIALELCPASLADVVERPDQFRDISIAFEPKKALRQITSGLRHLHALKIVHRDIKPQNILISSAKKGVGESAGHRMLISDFGLCKKLEIDQTSFLPTAHGAMAAGTVGWRAPEILRGEVKLDESGGEESQSSRGSIGLPPDGSTTGRPTRLTKSVDIFALGCLFYYVLSNGGHPFGDRYERESNIMKDTKSLDALDRFGEEGSDAADLICKMLSPEAYARPDTSTCLLHPYFWDPGKRLNFLQDASDRFEIMCRDPRDSMLIELETGAFNVVGNDWNARLDKWFIENLGKYRKYDGRSVQDLLRALRNKVLDFLTFFLSIHLPHVWRSMFQKHHYQDLPDNVKRQIGSMPEGFLSYFTRRFPRLFLHVHSVIAASSLRQESMFRTYFELTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0D8</accession>
    <name>A0A2R6P0D8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000597">
        <property type="protein sequence ID" value="PSR82194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0D8"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39678" checksum="C9863A310D1D4203" modified="2018-06-20" version="1">MRSFAKHDLQDSLRDVPLETWIEAVLGVSPRLLNQWITCIRKLNWFRDRIIGCALTDYARPTVTEESDIYKPFARITNRILELAKGTLPGVGDIYPIEDIKVVVNGPTSVERILVHGALGVSRQPDLLFVRGAQKDLSSDIGSRWVDVLAFLEFKLENKDLLIQTLNSCRDNRRPPIIDIKSGKSNHRSKRSDAKPATRRRALVGRASKTSQLSSHKGFNGPSFGGPKRRFDDMLEGEPDRSRGSSKKWKSDSLSSGLAACNALELASCTYGTRAFSLGSIVRDDKMSFWYYDASGYVRTAENLSIMKDLEKFAAIMVAFACGEPKHWGALPDIISPPPSTPYPASFPPPSLKGHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0G7</accession>
    <name>A0A2R6P0G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000586">
        <property type="protein sequence ID" value="PSR82433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0G7"/>
    <dbReference type="OrthoDB" id="3164356at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="157" mass="17125" checksum="E6B55CA786F0D605" modified="2018-06-20" version="1">MSDFETTADHSVFEEQPLACDTYEQAARAACAFVQPSPDLQKLKFYKGRLGSGADKIVGVGLPGTSTVLDLVRLDVDNAKKGIHFNARKVAGDNEHKLAAFIKPTVDMSVEERKKLYEGYLVPLQTIGAAVTLWNIWASGRRPTGDEVDIVEEESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2C5</accession>
    <name>A0A2R6P2C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2C5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="5937" checksum="E0A8510510263E3B" modified="2018-06-20" version="1">MSRGIRGPSESFLGDVRRGELTSTDIYAIKFGTKSSPRTGAPAASFCRPEHPRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2E5</accession>
    <name>A0A2R6P2E5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000537">
        <property type="protein sequence ID" value="PSR84353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2E5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8050" checksum="D1C7BDD228D8CD98" modified="2018-06-20" version="1" fragment="single">MSSTKATRTRSAASKLAVVMLPRAASSSASTSAADPIAQGMPAFVTQQVDRMESALERHAEDPDDEANLREMSNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5I5</accession>
    <name>A0A2R6P5I5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="1">AK6</shortName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="1">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5I5"/>
    <dbReference type="STRING" id="98765.A0A2R6P5I5"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003001">
        <property type="entry name" value="Adenylate kinase isoenzyme 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR85858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="187" mass="21263" checksum="BDBB66DDAFDF30E4" modified="2018-06-20" version="1">MATESSKTSPVIIITGTPGTGKTTHAQLLADESPVPLKHINIGDLVKEKGLYEEYDQEWQSYTVDEDKLVDELEPIVARGGVILDWHTCEIFPERWADLVVVLRCDHTKLWERLEKREYPLKKIQENNEAEIMQVVLDEARGSYPTEIVVELKSEGTEDLESNITRIVQWINAWKADRGMDEAKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8U0</accession>
    <name>A0A2R6P8U0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000516">
        <property type="protein sequence ID" value="PSR87212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8U0"/>
    <dbReference type="OrthoDB" id="3063170at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="323" mass="34387" checksum="C72F0D92B7480BFF" modified="2018-06-20" version="1">MSGLSVYDEDEDDLWNIGVSVNVAIAPTAEETLPNLWEDYGKKEPEIPKEDIVCRVHGKICPKGICKQRKSQEKELEKKKREAGRAQGGKKKKDKPWRVANDTDNNGARGDKIKFQSRQKPPHLAESASSPTVEDPPPANSPNTARGKPPHLGKSSPTEPAPVKPTAPAARPARGRRMNTNTDGPVSPSSPSNETANAAQTRNLRSDARSVAASSSGGWGPPVDLWAAVSVGRAATIKNDDTRSVAASSNGGWGPPVDIYSGAPSLNERRAPPAIPEGVNTVKQGSASTVKKSWADEMEEDDAHSVVESVNGGWGTISNSPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBU4</accession>
    <name>A0A2R6PBU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000505">
        <property type="protein sequence ID" value="PSR88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBU4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="81" mass="9196" checksum="B49733787C002B2B" modified="2018-06-20" version="1" fragment="single">FCQDAENGIIQINAEDFPCFLYPEDSYNLDNVEEGLLCGEFLCSGRFSICGQEGWALKDGRYKLEDLFNNIVELFDNPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC33</accession>
    <name>A0A2R6PC33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC33"/>
    <dbReference type="STRING" id="98765.A0A2R6PC33"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="218"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="286" mass="31039" checksum="196428C63C01DA31" modified="2018-06-20" version="1">METGQLALGDYLRYGRQMILDGFGLPAGLLEPFDIILDCTDNAPTRYLLSDTAVALRKPLVSGAAQKFDGQLCTYNFGDEGPCYRCLFPRPPSPEMTGSCQELGILGAVTGIIGNMQALEAIKIITGLHDGKPSLLTFSALSAPPFRSFKLRRRRENCPACGLEGIRIGSIAETDYVAFCGGHQPDWESRGMEENTSDARINAKTRLGIVVHHLTSDVPLKELVSDPLSHAPSNQESDTYVVCRLGNDSQIAVEAMRNAGMTGVIKDVVGGLKAWSRDVDKTFPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC35</accession>
    <name>A0A2R6PC35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC35"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6752" checksum="D57FE80D347E5346" modified="2018-06-20" version="1">MHWLPQMGLPKPMRPKSGQKTGWSDERYINIPKKKPGKEMPALWYWCKQSRHLSGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCC1</accession>
    <name>A0A2R6PCC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCC1"/>
    <dbReference type="OrthoDB" id="2524788at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR88876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="18548" checksum="C9933C5B91464F9E" modified="2018-06-20" version="1">MADNVDLFDTAKAHAADTEFFIRRGMTKGYQLLSLLTPPLYTAFANSRYGRSHLSVNRLLRATWVGGASGMVGGGAFEYVRSAYSDPQNVRKRRIKAAYDTDSIRADDHSTIGAILLAVFTPALFWKRANAVNLILGGAGIGSAVGLLSHYGRSISGDAPPPVIPRPEVTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCC5</accession>
    <name>A0A2R6PCC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000501">
        <property type="protein sequence ID" value="PSR89001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCC5"/>
    <dbReference type="STRING" id="98765.A0A2R6PCC5"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="458"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR89001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="592" mass="65377" checksum="3C136EC70874EB71" modified="2018-06-20" version="1">MIAQLSELSQAAQPTAFHQLLRVLDDRGRLLRVYTQNIDALELKSGLTFGVPEMDSRRSKSRSPKGKSDCQATSVPSTSAVPMGRLPSPPAETPRCIPLHGTLQNMHCQICLHSFPLENYLDDLNAGTFPVCPECSQMEEARQAVGKRSRGIGKLRPSVVLYNELHKDGEEVGEVVERDLIGNSKGKGRAGADLLIVVGTSLRVPGTKRMVREFSKAVHLRSSASQPEPTSSSTSYPTPSPRRSPVVEEDPPVKTIYLNLDFPVPTRDWEGIFDVWIRGDAQSFAEMVQAEIEREERVKEEASERKKRREEQRAEAARAEEERLKAEARAKTKFKSKSKVKSKVLGKPTALVHKKRKEVPGTITEPRPIKKRKVSVQVPMPASIRGRKTTKKTRDTPASQPTQARLTIKLPARSTQKAVSQATSYTPLTPPPSQRSSRLVPEVVIETSVRSRAPCVSAKLATPLSPPPSPLTSAPSSPQRPPAPLYSTFIVPNSSPLSSPPTSPLSSPPLSHMSSPLRHAPSPSMFRKRLPQMLPKRSVDISYGNRDCDTEDFIDIENEDVDSVSNPRSPFPTSYERTQGRALRPRAVTLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG69</accession>
    <name>A0A2R6PG69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000493">
        <property type="protein sequence ID" value="PSR90689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG69"/>
    <dbReference type="STRING" id="98765.A0A2R6PG69"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR90689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="756" mass="82893" checksum="45DB33E412B1A29F" modified="2018-06-20" version="1">MALVAHIDSGKTTLTESILLKSSYLTTAGSVDTGSTITDFLPAERERGITIQSASIPVVWRNWTFNLIDTPGHADFGMEVESASRVVDGAVVLIDSVEGVEAQTKGVWRQLDRYGVGSRIMFLNKLDRPGASFRSSLVSLLSHRLHPKPMALALPIASFDINDYSKAEPGIQGLVDLVNWEVWKWNQDGDSVRHPLPTDANQLEKTGIFPENHPIIPYLVPARTALLDNLSMFSDDLMERLLALPSTPSAYLTVPPQDVIPHLRAATLRNDILPVLCGSAFKHIGTELLMDYVGALLPSPVDVIEKVPSAKAPLRVLAWKVSWDKRKGWMTFVRVYSGTLTRQSVIMNATRNHKERVSKLLLLYANQTEEVETLSFGSVGVILGLLHTRTGDTLMSTKRSEDDDYLRDIVPPPPVMSASVLPQSHSDLGPVQEALNSLSRTDPSVRIELQEGQILVHGLGALHLEIVESRLRDEWNVNFEFGKRMVSYREGPGPGNIDPKPGSWKTEMFGKPFTIDVDLDVRAFKEGEKGDPLWDGNVVLGPNGRPLPLADNFTDQDDPLACISRGISNALSSSPHSNFPLSNVHIQVNKWRYPSQAMPASTLAGASAYILREILRVAGMGPLMEPYIRMKVTVNEESLGKTMKDLTEHSAEVFDLAASSVGGADMDEDVAPYSEDGVYLPPEFLSPASSSSAARNSTASLRRSIHAVAPLSQMLNFSSRLRALSGGHGVFEMANAGFREVTEGRKLEILKEMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNH5</accession>
    <name>A0A2R6PNH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000452">
        <property type="protein sequence ID" value="PSR94372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6PNH5"/>
    <dbReference type="OrthoDB" id="2658414at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="269"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1120"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1156"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR94372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1315" mass="148309" checksum="984C4D7664F2AB23" modified="2018-06-20" version="1">MSTPFEFNASYKEILRDSLHQESNIRHYRRNEELYGIKRPITITVKFSLRQFTTTEVHFLSASEDNVNPRDIINIVQGIQTTLGVIGEDFESALDIVGAVGGVLANVHPIVSLVVAAMSIPIKYYKKKIEFKDSLQKLAMEAHRLLQHLGQLELDDTPLNDFDILESAVVNIMEAIVEAGDFVQCYMARGNIGQTVTAQFSEAIQDLLEAFRRCREDFQLALSQKTHRAQSQKTLKKELREWLGLVMQERLEEECMEGTRKGILSSIDRSLDDPASYLIWIHGAPGIGKSTIVSSIIHQRTHKGDQVFTFRFKRRTDYPEPLRDPGMLWPSLAFDLAQSFRDCRLALIEAKKANPRGVAGVTKQFKTLIQGPIRNHLSAFRNCPRKLLVVIDGVDEATRDPPYWVELLDTLREFCQLSKESGGQLRVVISSRTLHDISAALSPLQPIRITLSVADSYSDNSEIWHDLHHFFTQHLRTEASKAHPRKWPRDEELRKLTEHANGLFLWADNAVRYILRPDGDKQRRLDFVLTHGYPGENNVKAPSALDLCYSKALQDSLGNREGSEKSLLMNFTRAVVISQVSLSIDDLVKLGVLPLGIDLSDLRTRLGCLLPFVEVIDSIRHFRAFHDSFRIFLVSERARKCHRFNESEENARQALYCLKWMNKPDTLYFNLFSIPSSYDATDDVDLGMVFGSKISPLLDYTCRFWTIHLTKATFNLNKGFPATIRQICKDLVDQLDVFFHCHFLHWLEVMSFLRLTNTVPEMIEDCLSWINLQPSPNQKLVKFVEDSHAFASIFAYPISRSIPHIYVSCLPFTSQESEIFRHFSSTFSNILHVPDISEKAVTRADHRGAPVTQKECVIALAFSLDGKSILSVSADCKSSMWDSRSGEMRKQIPLCGDDIVFATVASFSPDQRYIALGCIGTANSIHVYESPHSPHRIAKVELLSQKVIKCLVFFPPGSHLLACGYYEQVETKKDCYAWSIRILDYETGKMTPPAIRCSHAKPLSSLTISPDSRYIMACSADSITSFTFDSDNRLFYQYCLTDAFRLWDARTGRAITEPFAALFRKGEPMARDLEVAPAMNRVSSIGAPVYVADATFKEKTLLQNAPRNLVFAAHSAHKKLIASGGQDNRIYVWNTETGILLSTLTTMQTSGVHRCLAFSKDGAFIATGSGKGDITLWAVPEGQDTARSILPTFPVSRPAMLEVGNGQGGASGISSARSSRHSSLSRLGSRRPSPSPRSQASRGLDGKRMIWYDDYISVDSSGWIRDKSQSLLFWIPPEYRDEIRVLLPAGSSRTGIDFSNFMHGKYWIECQTLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNK8</accession>
    <name>A0A2R6PNK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000452">
        <property type="protein sequence ID" value="PSR94377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNK8"/>
    <dbReference type="STRING" id="98765.A0A2R6PNK8"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134:SF119">
        <property type="entry name" value="AT02038P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134">
        <property type="entry name" value="F-BOX/TPR REPEAT PROTEIN POF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR94377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="575" mass="65499" checksum="30B696B6C1577A7F" modified="2018-06-20" version="1">MSIIPRGYDSVMRRVLEIPEIVELIFSFLDKHSNAINAMVCKKWSELALNILWREVEVPSRLFGKFAPLKVAKALPRELGKGRYEFTRSLEAGDWEDFARYARRVRSLHVSETSDTNFLSKELLDEVARSRIWLNVLPGLRELHWLTPTAERMRFSFIFMHSNITHFAVSLHPSDGYPISAFFKEVLLRMPNLTVLDLRFRLAAKEIENNIRALLQGLPKLKQIILPVYTWTSGIVEEASKLPNLGTIQFEFMEPQGRGSPADVLDFAPRLEEGAFPALWDIALSARLPDITNFLTGSFAPSKLTTLYIHVISAAQPEVVTNFVTAVSESCKLLQSLYFEFLGDVSEEVGESESTISRLDWGALRPLLTCANLVVFEIRWYHPLTISYDDLEEMASNWPFMETLMLNCEPVDISIPPTLTLHALTPFARHCPKLVELGLYMSASVDVETPLERDVLAFQALRRLFVGLSRIADPGPVSLFLSKLCPLNCEVSSGVTWPDGFEGLALPEMERAADEWGHMWTEVNQMLPLLVKLRMEERENRQALQKEVEDLRVRCRLLSDRADIKMPDDDRCVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PWE8</accession>
    <name>A0A2R6PWE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000433">
        <property type="protein sequence ID" value="PSR97583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PWE8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="15293" checksum="C52C141F0692B71C" modified="2018-06-20" version="1">MPYCNRKRINRCLEKDICIEYIHIPGAGSALTVNETDKTAETAAVSRVMKFMVALGEYCRVKIALFARSVINGCPPQPEDSDTEAVFTPETNLPSVYQSRCRWSSEAYACSKQNWNAGRSARIRVGGSKRAFGGTGVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PZ43</accession>
    <name>A0A2R6PZ43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000421">
        <property type="protein sequence ID" value="PSR99316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PZ43"/>
    <dbReference type="OrthoDB" id="2802670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR99316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="15708" checksum="4B216935E912A0BE" modified="2018-06-20" version="1">MIALQKPAAFFSQPQAYFHRPSHSRNPSAPVVIRPTHTPGLLSLSKPAQQPSPRPQQVQQYARAPRSAPKGKQQRSPQPASAQPQPVEDSKKPSPYMVQADLALEKAAKSVTAVPASDRSARGRQSTKPAAKDKADRRYDLPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q5D5</accession>
    <name>A0A2R6Q5D5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000398">
        <property type="protein sequence ID" value="PSS02345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q5D5"/>
    <dbReference type="STRING" id="98765.A0A2R6Q5D5"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="218"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS02345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="527" mass="59905" checksum="441EEECD497F60C1" modified="2018-06-20" version="1">MPNTADRRRDDWETPKMAAFLDDAWNTSKDNLTHYDRIVTVLKNHHHCDVDIVTLQELCDVLHTYPVLFAASSQLLPDGQSMYLAPDFPGTSLFQVTTSDNKSAWRASFGLIHAENLHEIPDVDDKILCFLRRAVICKDREHAIVTLQGGDAQRTLDIMQNLLDDSDSWAKFVADIEREHSVMLDDSKWKRVRRLMVKLAVSCRYLPPSLYLKDGIQLELVYPVNRGSNAEIYRGKYKGDIVAVKRLWFGAPLGRTEADQLREALYEEALIWRQLKHPYIVTIFGIDCKLFSGSPTNDCIVMPYMEPGNVRQHMDYLEKQRKPAPVNLWLLQIAEALSYLHEKGVVHGDLRGANILISNDGTVRLTDFGLSILLRTRSSSKARDFPDGGTAQWMSPELVLSSNYLADHATDIDIEAPASAGEDAYYMSLIAPPVDIYAFGCVCVELYSRADPQFHGIIQRGRNVSRLIQDAIGNGRRPDRPTAEGREMSEQLWDLVQDCWKQEPLERYTAKKVHSSLKLLDVQIQMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7C3</accession>
    <name>A0A2R6Q7C3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v4015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000390">
        <property type="protein sequence ID" value="PSS03309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7C3"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7C3"/>
    <dbReference type="OrthoDB" id="3364766at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="7">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS03309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="117" mass="12963" checksum="469B8539ED2973D1" modified="2018-06-20" version="1">MSTPATSPSDATKADATNAAAEAVVDKGKNKVVEDEVMDDDEDEEEEEDEEEEDEDEDMAEEEDLAEIDPSAIRSRRTRGVRVDYTSPEALAKAGLKPGEEEDEHEDVYEAKDESMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7I4</accession>
    <name>A0A2R6Q7I4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000385">
        <property type="protein sequence ID" value="PSS03513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7I4"/>
    <dbReference type="STRING" id="98765.A0A2R6Q7I4"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="254" mass="28907" checksum="B6B3D3AEADC100E6" modified="2018-06-20" version="1">MKFIVSQSFPTLIVIGTYERYLAQGQRLRQSGSDAAHSFYNSFSRRVKYVPFLERLVGTSTTDLYDAIFDVDASHGLELFGDSDDEAERTAWRAQISQESLRPPSPSSSRHPSSARRTRSVPHSPDSRFERRRRVLSSTTTISPRRRPAVLSTFLEPSSSAEIQTVGPRSPLSRLFNGRGESSQERLHSLNTEAAMKKLENLVEEIRHLPVNKLKEEMKELQDRQARIENLLLMLTRGMRNETGPKSTVRNDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBF6</accession>
    <name>A0A2R6QBF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000371">
        <property type="protein sequence ID" value="PSS05459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBF6"/>
    <dbReference type="OrthoDB" id="3195323at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1031" mass="112355" checksum="20B5BF93AD91817E" modified="2018-06-20" version="1">MSALPTSPHNKSWWSRSKSRDAPVLRSQASGSSLAQDARSTRSKEHSSGSKFNAFVSNAIGKKSKKPTLTIQDPPPPLITTFSASSSVRSPMASPSTSIGTTPLHQTYYANRPPANSISTVRSYEYDIDQASDRHTISEPRTPSDHPRDRTSYQNSLLTLSDADPFAAGGIIVSRFDQDPNRLSVWSDSSLLDPHSKRGDFTGSNRMSYGSSSSNSHASEGQTRPHPVARIPSDGGASQKRHRRETSVLYDNGFPGVPPDPSVSRAQLHQRTTASSLYSSAAPPSSFVGASVYSAVSKDVLGGSSRPPLRPRGMTVAGERNPGLNRGTPDVPTSVVPPHLRRKASDYLQRTQSPPSSSTASPIMFSSVRSSLSSSSITAAPPSSSTRPLVLVRKASSSRVNLPPLYAAPPSSRLPPPPLSPFSTSDTEEFMEALVFPEVPSSNSSSLSFPSANLDMSSGDEIRHFMRDGFMDDDFGSPPRTLRNIDLETPPRQTGRGRVDTYDRAPPHLSSSNLLKKAISQQDLMGKRHSEISLASDSSVYDDSTPASPIRSLNGKEPRKQRSFHHPRIPLPVLPTLRHANSYINAGGPAPEPPASPRSPPFGPSTSQSTRKRLFSGSSGRKNSLSKVSPSPPLAGDDDVRSVLSMETGESISREGSPLASVRQQPIMVSFANMGNQLSLVTDNACIAPAWEEIGSYTTPVNRRVSQSDYVPQHIMSPADMLKLEEQLADESASREEDKQEQEQERPQEQERKPKLELEPGDFGLSFAPGGRQKPARSRTNSILSNMSAATSAFGNAEKHVVEDRSIRNAHTPSGTPPRRPVTANDFTRAGVAIDTRQPLRSTSVLSRGSKSPTITARSSTTQLKLSPPSSPTTYSPPSLEYSAGGLPPPPRRRRAREEKEKEKEVDRDPSNKRISIAPFHPLSPPPRRKTTGTSMVHEEFGQEQQQQLSPLSSRPPSAFDPQKINKRRSIMRKPSFLEIEDDADHETESLYDVQVDIQSLEMESSFLDLDRGKDSFDTVRSCDDDFINRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM44</accession>
    <name>A0A2R6QM44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000322">
        <property type="protein sequence ID" value="PSS10997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM44"/>
    <dbReference type="STRING" id="98765.A0A2R6QM44"/>
    <dbReference type="OrthoDB" id="3251181at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS10997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="15638" checksum="1A7D887501E88082" modified="2018-06-20" version="1">MDLWEPSLVHASGGLQYTFTILDEATGWLYELQLRTKDQAFGRFVTWHSQNGIHIKMVHSDCGGEFLGKNFTNFLEAEGIIQRLTIHDTLERNSMAKHVHHTIFNTVHTLVAKSSLPPFLWGKAHKHAIYIYNYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R105</accession>
    <name>A0A2R6R105_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R105"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS18925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="7952" checksum="7E794CD61948FC79" modified="2018-06-20" version="1">MACPFNTIPKQLPRFFALITRVASQFWRLLDVFLTIFNFIAITSFTLVLVLMQSGPAYVDGLPSNPYLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R125</accession>
    <name>A0A2R6R125_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R125"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS18945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="53" mass="5921" checksum="19624C8D8DD8D341" modified="2018-06-20" version="1">MATHNFEFVVSKVHKTEYKGGHSFVVTRRTIVLQGRDLAIYGLDPASPNGFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7A9</accession>
    <name>A0A2R6R7A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000272">
        <property type="protein sequence ID" value="PSS22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7A9"/>
    <dbReference type="OrthoDB" id="3235423at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="597" mass="65741" checksum="BEF6D63471F52BFB" modified="2018-06-20" version="1">MSQPERKPLQLASPYSWHAPPLPTTFTVPGHTFTTSPDRIWYRKPWAVEAAFSLASFMAPGLYDMFGSCRIHLSEPSASQGDSNTMAAETPTVTFNHVREAVKALRFSHPAIACRLAFTREVLSPHPSDPTGLPTPEDARLIYEIPKCEADVDKWLDEIVFNRVDLLDIAKGDVDKAFELLKRELGEAKAQIGLPKVLFNVHWIPFPAGTGQGGMLLCCCPHVVFDALAVFRSLNEIVGNIAQIAGSRSPSKEFSWGEELARLAGPAVDYGVVPWSAGAGKEEEVMVTKMRETFTGIPEPYGLAVPRPDAAPSTTGYFLRQLSPETVKGLVQNARKNGCTFYGIAFAAMALASLRVNPPKRNDPGHVTEKELATFVHCSPLDLRPRNLDVKRVSEGDVMSALGYNVLVARDLGRFLKGEEDIWALARETRAQLDDQRQYMDRVGSWAHELFVGGLEMMMGTLGARAARGENPDQTPFMSSIGVIDKYLSPSHPIPGSNELADNADSRWKLTISNPTLTVRSPYSPYLSYTVGVHSFTWYGTSYLGFSFPEAYMGTVEEQERLAGISLEDKNARGTVLEWVDEFVGILERVAAGESRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHS1</accession>
    <name>A0A2R6RHS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000257">
        <property type="protein sequence ID" value="PSS29561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHS1"/>
    <dbReference type="OrthoDB" id="2801766at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="139" mass="15038" checksum="E20ADEE904EB793A" modified="2018-06-20" version="1">MVEVYLQRQYPPPQKNDASPVLPLLSTVNCPSRPDDSHAAGPYPSDHDSAAAPSTCKAENAPCDSPSGHESPADSAEHDKHYHFSVDVVDIYTLETSVKIKPRVTVKSGAAALVMQGYIRVLPVNPSLAISIKTLELYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI94</accession>
    <name>A0A2R6RI94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-quinone oxidoreductase subunit D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v2887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI94"/>
    <dbReference type="STRING" id="98765.A0A2R6RI94"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="3">
        <location>
            <begin position="142"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS29739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="321" mass="36313" checksum="4B9FFAAAFC5A654C" modified="2018-06-20" version="1">MASAILRRQLSRAPRQLASTTGHPSLASRHISKSALVHAEPLRDPSDPRTGTQSRGARGVFDTHTVEDLHGMHASEILVETGTRKDAQMRHFTVTNELCYSLAVEKLLNIEVPERAKWIRTLFGEITRVLNHLMAVLTHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVAFDLPHGLLNDIFMWATQFGSRVDEIEEVVTGNRIWKHRTIDIGKVTAKEALDYSFSGVMLRGSGIAWDIRKVAPYDKYDEGQCFQVEFDVPVGKNGDCYDRYLCRVQEFRESLRIIHQVCSSADSSKYWVNPSVMYLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIL2</accession>
    <name>A0A2R6RIL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000248">
        <property type="protein sequence ID" value="PSS29867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RIL2"/>
    <dbReference type="STRING" id="98765.A0A2R6RIL2"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015347550" description="Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="2">
        <location>
            <begin position="199"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS29867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="268" mass="30669" checksum="0A4BB64742E20DB0" modified="2018-06-20" version="1">MATGGVLSWLMLPLVLNAETFFKVITAVNSTIEESTSLFAVRAHATDATLFLSGRDLFAYLKRLETKDTILKTIDFEALKTEAPALAAATPAKKEKEDAKIEGSVQIAVGVKKEVDFATWYTSVSMRRTLVFCRTNFYLQVLTKADVIDYYSVSGCYILKPWSYSIWEIIQDWFNSKIKEMGVQNAYSPYYARWIHSHRDLPLKLNQWNSVVRWEFKNPQPFLRTREFLRQEGHAAHLTKPEADAGVLEILDLYRRNYEGLLAVPVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLJ8</accession>
    <name>A0A2R6RLJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000237">
        <property type="protein sequence ID" value="PSS30892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLJ8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="131" mass="14840" checksum="8EEFBA0A870F1F23" modified="2018-06-20" version="1" fragment="single">IPGSPSSASSAGNLTTIEYPPRTKLDLRVVVWSECKALIVIEKNVPTTFRFIDLKKISELVGAEANLKLKIWSDDRAEWVSRGCDEVMTMGQGHFSLLARREEVDRIDRDQWLQEVQRLQDGLRALEVATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM47</accession>
    <name>A0A2R6RM47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v2360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000220">
        <property type="protein sequence ID" value="PSS31104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM47"/>
    <dbReference type="STRING" id="98765.A0A2R6RM47"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS31104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="236" mass="26727" checksum="0E867E9D4401ABE2" modified="2018-06-20" version="1">MDFYRSTDHHRVQEGLEESLKKLDCEYIDLYLMHWPQAVLNDKVLCEDEHPTYADTWKQMEKLLDTGKVKSIGVSNFSIKTLEILLPQCTIIPAINQVEIHPCLPQFDLKEYCDSKGILLTAYSPFGQSNQLFFKDPDFIAIAECHEATVAQVAVSWAVQRGTVPIPKSANVERMKANITLIKLTPEEMQTINDIHKKPGMHRSLLGYHGPDGSVFGWTYEQLGWPMSVGGFVSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ31</accession>
    <name>A0A2R6RQ31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000196">
        <property type="protein sequence ID" value="PSS32126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ31"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="19721" checksum="C23E3484CE0D6EA7" modified="2018-06-20" version="1">MLLDAGADLQLVRDPLHLATSIESPDLDSRAIEILVRAGVDVNGRNLEGETPLICATVYTEHSKNFEIISKFDGKLDWNARDKWGNTALDYALEYERPKEVIRLLKRHSALDIFEHDGGSVAQVKIWTWTYGEIGYRCPWCQCWPRCGKKAQRDRYHSDKDEENLVMPGAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVZ0</accession>
    <name>A0A2R6RVZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v1752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000141">
        <property type="protein sequence ID" value="PSS34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVZ0"/>
    <dbReference type="STRING" id="98765.A0A2R6RVZ0"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="11">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="10">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="640" mass="69656" checksum="2A95CFB59338942B" modified="2018-06-20" version="1">MPGAKVFTNTPLVHEAREGVMEFLLSNHPLDCPICDQGGECDLQDQSMRYGADRTRFHEIAGKRAVEDKDMGPLVKTSMNRCIQCTRCIRFANEVAGVEELGSTGRGNDMQIGTYVAKTMNSELSGNVVDLCPVGALTSKPYAFHARPWELKHTDSIDVLDAVGSNIRVDSRGVQVMRIQPRPNDDVNEEWISDKTRYSYDGLRFQRLTVPLVKQGDRFVNASWEEALSAVSEGLARSGASGDEIQAVAGHLADTESLVALKDLVNRLGSDNLALDHVTGHAAPVHAVDVRSNYLFNSTIPGVERADVILLVGTNPRHEAAVLNSRIRKSWLHTGLEVGFIGERVDTTYGYDYLGDSAKAVADFVAGKGEFAEKFKTAKYPLIMVGSSMAEHPDGAAVYNALAKFVEKNKDRLLTPEWNGFSILQRAASRAAAYDIGFVPSKKASSAKPKFIYLLNADDVDPKSIPQDAFVVYQGHHGDLGAQLADVCLPAAAFTEKSTTWVNTEGRAQIGRAAVPPPGASREDWKIIRALSEVIGSPLPYDDVLSLRDRMWEISPTLVRYDTTESTSIDVAVAGLKSLIAGTRTAQVTGAPFKKPISNFYQTDPISRASVTMAQCTRAFTKGENYGFSELSSAPEAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZP8</accession>
    <name>A0A2R6RZP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZP8"/>
    <dbReference type="STRING" id="98765.A0A2R6RZP8"/>
    <dbReference type="OrthoDB" id="3260456at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="2">
        <location>
            <begin position="202"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS35459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="507" mass="53895" checksum="BE1AB0D8FDDB0958" modified="2018-06-20" version="1">MSTVGLEQAVSIPLPTSPPADGDTPLAFPQAGPVEPGNRDPVDENSARSIHNEFTQAEDKGDEADSRDVDDVARVISVSSPQLAASSGDTTAHDEPGAGSKTTVHHTTQDTVSTLPSIPRTPPAKPDILPEVHSPPPRRDSLTPSTVHSPNGHMRPAVQQVETKHANGRPSIQSTPSRPSSAASHRRSLTISKGRTVSAVLVTSALETIAASREAKRSEPLRESVKRALEMVKLGEGGDRPRVIFEPLRLACETRNEKLMIASLDCISKLISYSFFVEPLTSEHAGAPPSPPPSPGPNSRHSTSSTSHPQIPGPTLVDLVVHTITSCHTESTPDTVSLQIVKALLSLVLSATVLVHQSSLLKAVRTVYNIFLLSMDPINQTVAQGGLTQMVNHVFTRCKLDGKLDGSSLSRSDSSSTLSSKMGDRKSPSNRRSFTPSSPLSMQRPLSPPSSADHSSIAQRIESAAGLADQPNGSVDTPDTDTIELSVESFSEDHLNGSLPHLSQHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZY2</accession>
    <name>A0A2R6RZY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000120">
        <property type="protein sequence ID" value="PSS35539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZY2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="75" mass="8356" checksum="3CCA76327410C363" modified="2018-06-20" version="1">MVEDCGAWRLRSLKIQGREGWIQLSGHVGKRIQRIAPGIAYKYQDCVGDCDGDVAYAQKDPIYVVLSAEVARAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3Z5</accession>
    <name>A0A2R6S3Z5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS37007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3Z5"/>
    <dbReference type="STRING" id="98765.A0A2R6S3Z5"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="180"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="619" mass="69616" checksum="5868070D8BB1A64E" modified="2018-06-20" version="1">MSYYPSADDGRLGRTPNPASIYQFDTQQSKPQPRANTPERIRERQVKSVPPPYAHTPPDELFYLQDPSTGVLKPNVELLKDHFLHEGRLTEPQAMFILEQTTALMRTEPNMLHVASPVTVVGDIHGQYYDLMKVLEVGGKFSENNYLFLGDYVDRGCFGIECLLYIYALKLWYPSTLSLLRGNHECRHLTGYFTFKRECLHKYSPEIYEACIQSFQALPVTALIDSKFFCVHGGISPDLVYLSDLDKLDRFTEPASSGLLCDLLWADPIHNYGHETDVNEKNPRGTRPPPFLPNDTRGCSYYFTYEAVSEFLERNKLLGIFRGHEAQDHGYVMFRKTTGKQFPSLITIFSAPNYLDVYHNKGAVIKFRDKSITIRQYNATSHPYWLPNFVDAFTWSLPFVASKILEMLLGVLNVCSEEELEASDDEDAFSSRGGGPEGIVPPELVAERRSDIKNKILAVGKMQRLYQLLREEAENASELIADAAMPPMAGTPPGAWPGGFAPPDGVPDELGVGVHHLRRQIRSFDDARHADLFNERLPQFSPPPISIEAAPSMWVPRLAAENDGQGGGTHVAMESLIRRALEEEGVDDTDGVAERLAERIARTKGGSLRPRGLRRFDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S458</accession>
    <name>A0A2R6S458_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v1141</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000088">
        <property type="protein sequence ID" value="PSS36999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S458"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="889"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1258"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1893"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="15">
        <location>
            <begin position="883"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="14">
        <location>
            <begin position="1024"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="1120"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSS36999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="2020" mass="226135" checksum="18574F41FD6C0CEA" modified="2018-06-20" version="1">MAGMPYARTVPSTHALPPSFLPDAGLVFDTLLKRDEFTPHPGGVSSLFFAFADLVIHSLFNTDPKDRTINNTSSYLDLSPLYGNSEKDVDSVRRKDGTGRLWEDVFADKRILFMPPAACALLVLLSRNHNYIAHKILSINEAGTYKNPATLDEKTRIEQDDEIFHRSRLVNCGFFMQIILGDYVGAILGLVRDGSPWRLKVLEPLRELDHQIAPRGEGNVVSIEFNLMYRWHATLSEPDTEWIEAKFGKMFSGKDLGKLSPRDFGAFYKKVETEPADVKTWTFSELKRDADGRFDDASLAKILQDATESYASAFKARGIPEALRVVEMMSIEQGRKWGTCSLNEFRRFMGLKPYSTFAQWNSDPEIYTAAETLYEDIENLELYVGMQAEEAKKPGPGAGLCPGYTISRAILADAVCLTRGDRFLTTGFTPQNFTAWGYQDCQFVDDDGSFGGMLTKLLFRTLPKFYPAGSAYAHFPFMVPEAMEKAAEGLNIAQEYTWTRPVPESSLPNPTFVMKQAENLHMERLENLTGVCKVDGRLLDGILSSGIDIKRWGETFFRIANQLVADRSDDNTISKIKCIDIVRSVVNLVPVQWLENEMGLCNDECSHQSRYEKFANIAHYLYLNTLPEQEFILRKRAQESSRPLNEHIICKLRQNTKQPAPLFRSFGESPEHTSLFSVICSWGALNGYSKEVLAAALLDDIIGTAALYSRAVIWIADYLLDHKPHVIESLISNDFRHDDKSMSQCIQDALNIVDEGGIRHGLMNEKFMNASSLIEVPKRCDGHDGATRPLLFWKAAGEHNQLSSVPSSTTLVAVLLLQTTLYEQPSCLYSRTSSDDCQVLRLRARQYVRVDRRTFLDVFQCFYRASVKVESSDIVAAALHKSLPWYTHLYTIPFLSLYPLLAYAYYVKYDEWIQSEEWTFLACVTLGAGHALSFLVTRWSTGARAWVTTRKAKSLQDADCIRLIPSAHRGIGEIVPIYKKVEADPTTYTFSYQRDTYVLQSASPIVFTLLPYPSSSRPALSKYHSPKGLQSSQAAELISLYGKNEFNIPIPSFSALFGEHATAPFFVFQIFCVALWCLDEYWYYSLFTLFMLVVFECTVVWQRLRTLTEFRTMSIAPYPIQCKRDGKWKVIQTDELLPGDVVSIFRQQTETNVPGDVLLIRGTCIVNEAMLSGESTPLLKESIELLEGSETLDVDSIHRNAVLFSGTKVLQARSGGDTPDGGCLGVVLRTGFGTAQGQLVRTMIFSTERVSANNFESFLFIGFLLIFAIAASWYVWVKGIEREMKKSKLLLDCILIITSVVPPELPMELSLAVNASLVALSKHAIFCTEPFRIPYAGRVDVCCFDKTGTITAENLVLEGIAGVDASDHSKLIDVKEASRETTLCLAAAHALVRLDDGTIVGDPMEKTTLDALNWQLSKGDVISSSDSGSPHRTTLQVRRRFQFSSALKRMSTICSVANGKHIIAVKGAPETIKGMLGQVPSFYDETYQRYTRRGSRVLALGYRELDNTSSDKINKISRDQVESSLTFAGFLVFHCPLKSDAVETLKMLADSSHRCIMITGDNPLTAVHVAQDVEIVDRDVLILDVRENPAHEADLVWRTVDESKVIPVNPAEPIDPSIFDEYDICMTGAALKQFENRPSWNQLVQHTWVYARVSPSHKEYILTTLKSLGYVTLMAGDGTNDVGALKQAHVGVALLDGTLEDLQKIAEHQKAERIKKVYESQLKISARFNQPPPPVPAAIAHLYPNVVEAQQKAAQELQNARKRNPMEKFDLAAITDKLADMEDEEDVPKIKLGDASCAAPFTSKLSNVSAITHIIRQGRCTLVATIQMYKILALNCLITAYSLSVQYLDGIKFGDYQVTITGMLMSVCFLCISRAKPVEKLSRERPLGNIFNFYVLLSVLIQFALHIGSLVYITALSRTHEERDVIDLEAKFEPNLLNTAIYLLSLSQQVSTFAINFQGRPFREGIRENSALYWGLMGASAVAFSGATDFMPELNRWLQIVEMENSIFAFDTACKIHSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S487</accession>
    <name>A0A2R6S487_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v1064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000082">
        <property type="protein sequence ID" value="PSS37098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S487"/>
    <dbReference type="STRING" id="98765.A0A2R6S487"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="32"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS37098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="703" mass="75935" checksum="A4CC1D7CE68862C2" modified="2018-06-20" version="1">MAPKQPCAKYQYVVTSQGPKILPVPEAHSKDEESPADYNAGGYLQVKVRDTFKDSRYTVLRKLGTNRHSALKVVKSAGRYAETARDEIKLLRQVMAANPIHPGRDHVVSFLDSFNHSPTTQSLAAFAGSDPHTQLTSNVKALSSSPSSSSSADVHICIVFEPLGENLLALIARHKQTGVPPALVKVITKQVLMGLQYLHEECQLVHTDIKPENIMISIPDVETHIQQELTSSPSPTSRNVGVPPKQGTRASVAIPARTIPYSLNTSGLAHTPSPTKAKPIEKHVQIFDSKPLLSPSSSASWTSRSLFAGLAKMRDEPGVDSLKAVGTKGKGKGKTIAVDTVLGKQTSSDSSEDSDLSSGPSSIAVSSSVATSCTPPTSIGSVSGAFEKVSMMSPVDGKGKGKSSNLTQVQLEGEDESGRCTCGDEAIMGQSEATSTTTVNGDSRSEDGHNHTHKSNLPISGPSLLSQTAPLDLHPHRPHCSTHSNRNADVSPSPSAPLSQSPVVEPLSTSPSASPTPMPTSTAPLLSVKIADLGNATPLHKHYTEEIQTRQYRSPEAILGRSDWGATADVWSLACVVFELLTAEYLFDPQSQGELFGKDDDHCAQIIELLGKWPSEVVWGGRYSREIFDGSGNLRYIRNLKPWPFKRVMVEKYSWSETDADALCEFLLPMLNIDHRSRARACDMLNHRWLEVDVEAELKQLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4F2</accession>
    <name>A0A2R6S4F2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4F2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="132" mass="14838" checksum="FE1AF8C57B549B2B" modified="2018-06-20" version="1">MLEKDPCKRITIPEIKAHDFFGAIDWDQVAQRSTKDKKSFQYGVGSSPNEPPIDIPSSEAYKQGQVPFPWFEYASPVLYKAVQGSPLFNEDSPSKFTSVNNDIHGKTTPVKLVRRLKGIWSRSPKSPDVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4W9</accession>
    <name>A0A2R6S4W9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000067">
        <property type="protein sequence ID" value="PSS37293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4W9"/>
    <dbReference type="STRING" id="98765.A0A2R6S4W9"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="328"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="602" mass="69164" checksum="43CD34FD0FDF5648" modified="2018-06-20" version="1">MTWISGREIKDTLIDAKGTGAGELTIRFDVSFGPSAQFTLTEDLCRDYPTANRLRNVIRQSERIRDLDIVRNGIHASSGTRTITLWELWRAAQSNIRMRYAKSLKVKIDEWFKYVDSLQRNVWRYPETIVKDGVLRYNAAEDLLIQISLLVDYFLDTHQVKPVKSDVASELVYGIAQAVLLLEEVVNEPIISLMYSQLRSRDKDFMDRRTCLFNLRCKLLIHREGHSRQEVLEGVDRWKPTDLLRYAWNERRQEPNQRPFTDALLFLRGPEVQFVFECINMLMTADAKKPENGLTAERSSFFRRILTHLAQHAERLPAFLFLKNVEQNLSTRPSQWGSFGSIYESEHEGTRVAIKLPRVFAGENTGKDKALKQFYQEVIVWQSLRHEHILNILGVTYLSELGAIAMVSPLMIHGTLGGERRNIKEVSTRSVNTWIKQIAQGMAYLHDQEIVHGDLRGDNVFLDENYSVHIADFGLSVYADGHSGNYHSLRSGNERWTAVEMLFPGNFPDVSQSGRPTKEADVYSFACVCVELYTRKSPFSDLNTRSVALHVLAGRRVDRPNGPDGRPMPDALWALVQRCWAQNPKQRPRFRAICEQLDGMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5U2</accession>
    <name>A0A2R6S5U2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000033">
        <property type="protein sequence ID" value="PSS37648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5U2"/>
    <dbReference type="STRING" id="98765.A0A2R6S5U2"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34975" checksum="E3D9FDFE9BDF10EB" modified="2018-06-20" version="1">MSARAIWDSLVFSLKRHIAYTILDKPTSFPAWGFVRLAFLMTIMMSIPALLWFIAITMAPLSDVTALWNTNAFFAYILTVKLYHLGWEVRRLASVLLATLGAAVVVYGGNSASAPEETRSSESERPPNPMIGDLLTLAAAIVYGIYQVLYKKYAALPSDPDAELDGLDRTTAYEAITDTDLEDSIDDRNDIAYPPPFALYANCLTTSIGLCTFFLLWIPIPIMHLTGVEEFHLPTNLTTVFAIAGISLSGVLFNAGLMVLLGMWGPIVTSVGNLLTIVLVFASDAIFGGAIQTVTVWSVFGCGSIVVAFTILALDLRKGSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5U4</accession>
    <name>A0A2R6S5U4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000034">
        <property type="protein sequence ID" value="PSS37623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5U4"/>
    <dbReference type="STRING" id="98765.A0A2R6S5U4"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="24111" checksum="22BE5D3240549AB8" modified="2018-06-20" version="1">MGFAHNNVLHQNHFRKDWQTRVRTWFDQPGRKLRRRQARKEKAATLGVRPLTLLRPAVRAQTVRYNRKVREGRGFTHAELKEAGIGRKAARGVGIVVDHRRRNLSEEGKALNVERLKAYKNRLIVFPRNADKPKKGDSTGDELKVETSRLQVPLPSPYVHETPRKITEEEREFGAYRTLRDERANARHEGKRKARAAKKAEEDAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S640</accession>
    <name>A0A2R6S640_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S640"/>
    <dbReference type="STRING" id="98765.A0A2R6S640"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="489" mass="52311" checksum="81F1484FD1EA7155" modified="2018-06-20" version="1">MPQSPQSPSSSKAGSDDNVPGESAQRKKKNADAQAAFRARRANYIATLEDAVTNLEAVVVQLQESLRQSKYDTSNLRTEVSQLRKEATDREKFWRALWQTRNTGMPPDPDDTFNMPSYAQSHSSPGSSRPPSTPSPTMTAATHYRDERLRYSADPSVTLVSPSYRSNHLQQHSPAMGFAGVPNLAPATAAAGHSQALDSQTLHSYTTHVPSYGMDGIVRDEQWSQPGSYASDSIADHGRSDASPSPTFTESPTHTSSELAYGGGDDPKLPYNTAGSSLYMFSPSRSISPASTPTSTSSSLSTYAFTFPEGTVVQDRPEFIYRRPPLGLHSPEIRLHGGQANIPIPAGTLGDALRSKLNGQGKHHPSSMPASYTQMQGPPPESDASSESSASPPINRLRRRRSTIGDAPISRGSRSPSPVAPISGTLAVIKAHTFGALRKTRGRHRTNTDGVVKAAVDALSVHGLGLGIGIDSISKRPRLHQNGGDGMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S677</accession>
    <name>A0A2R6S677_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S677"/>
    <dbReference type="STRING" id="98765.A0A2R6S677"/>
    <dbReference type="OrthoDB" id="2803503at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15798" checksum="26DADA251463EDA3" modified="2018-06-20" version="1">MSLSPTASTDYDHQHQPTSKRRRTSDFTVNNPYDPHNGMAGPADSPSSQATPQSVHIPKRGARACTACRKGKNRCEGEVRGPFYPLEPFLRLPPSRCCSQFGPPLRPARVSQAPCRRCQLSGTPCVFEKPEKKNVQAMSSGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S679</accession>
    <name>A0A2R6S679_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000030">
        <property type="protein sequence ID" value="PSS37794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S679"/>
    <dbReference type="STRING" id="98765.A0A2R6S679"/>
    <dbReference type="OrthoDB" id="2804598at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="67527" checksum="93824F1BC59B09F2" modified="2018-06-20" version="1">MSPIELVQYCTPPLVREYVSFHSQLLHSQLLHSQLVQLRYICDRLAKFRRSKRKVADISEAIAQISPEDPSTTSHIFSRGIFVKKRKAVDRGDAIAQISPAEPSTPPPTPSRFLALPDNIHDRIFRHLSCPVHLILSTTCKRLHARRSAAYTDLSFTLAGTEGPDVMIHTLSSLRLLADVLVAHPEYCASMRTISLSYDKAQLGPCWEDPPWIWVIMMDTLDKYTARIIPMAHGLRRFEWSIYGIVAPLKRTMPQLNLLPDLRELFLSNASVPCNDDTNLKKKPFCLENVRIDVLVSPDWCNTLLRGNTSLRELHLVGWSRDVPDGSQWLDSVQSAAATWLNLHILSVDMIWDHDGRNLKSMMTFLGRCAATRCWPSLSTIAIDVQSHGNLVHNLMKILSYFPIRRLHIGGAILFIPAIATCLPLLEELSLYNHEILPYKLLHGDLQTWGASLRGIRNLRVLTLPTRFVTDKTGQLPMKNGVHLPHDTNHDLDHSSWLRPIYTRLSMFAETFLNNYLRKPHFLELRFVHPLHPDSGNTGGGRMVRFRQIPDTRHGVGSDGRERYTIVYLGEMQDSKEEDETFFWAPRMDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S712</accession>
    <name>A0A2R6S712_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v58</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S712"/>
    <dbReference type="STRING" id="98765.A0A2R6S712"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="129"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSS38078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="454" mass="49848" checksum="FCE3CEDE3E3ED43C" modified="2018-06-20" version="1">MSGAIFTKWFCEWILKTSGVSNLKGARDIQWALNEPCSITYYDPFVKLGCNTPTLTRGNTVCGVVFTKGKTMAAQANTHQNRDIRPTPTDGYPTLTSVLQTSTERTLQPRLELALSDSLSESEPASAVLQRNAHLQFLLRNLVQGFPARYVSQDASQPWLIFWTLQGFSVLGVGLDEKTKKRAIETLLAMQHPTGGFSGGPGQFPHLLPTYAAVCALAIVGHPGEDGGWDQIDREKMYKFFMSLKQLDGSFLVSRDAEVDVRGIYCLLAVATLLNILTPELLSGTPEFVATCQTYEGGFGNASFPEWAFGTDGLANDSPIPRPPLGEAHGGYTFCATASWILLQPYINTHYSPSQRPTINLPSLLRWSTQMQGSHVELGGFRGRTNKLVDGCYSWWVGGCVVLVEGLLGIESKGVDDSEKKGEEDHDAWDDVDDLRTHITHYIVSLASRPHSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S753</accession>
    <name>A0A2R6S753_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v52</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000005">
        <property type="protein sequence ID" value="PSS38072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S753"/>
    <dbReference type="OrthoDB" id="2746456at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS38072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="335" mass="38047" checksum="5C49035876C9FE06" modified="2018-06-20" version="1">MLPAAEHATQDVDHTNVESSDIDHLESSVAHHKPQSNTFWFDEAADCIVIAVQGTRFRLLRAKLCKNSKYFTRLFGSASDDADRCYDIDGVSSDDFKALINAMDDAILYVLEPPPSPVVASILRAAHKLECENILRFSKQLLCEIWSPDLHRLSTAPIPSALPTILLARDLDISQVLKRAFYELLRNSEPREGLSEEDQRRVNTAHGELQMHWAGFLWTTPNSHAFRCHTPSSVQHPPIETTDVDKRNETAKSMETEKEMVCTAQLERDHFQAWRDLLEEHGLFAVDDPLGALQSLAAINWEKMGYCAGCVEGRCEAFIRKRDELWNRLDGWFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDT3</accession>
    <name>A0A2R6NDT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">PHLCEN_2v13566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDT3"/>
    <dbReference type="STRING" id="98765.A0A2R6NDT3"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="356"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="619" mass="69708" checksum="CD51AAE8758070B3" modified="2018-06-20" version="1">MGRLRQKGKAGAAKAYVTRSAAVKKLQCSLADFRRLCILKGIFPREPRHRKRANKGSSAPTSFYYAKDIAYLAHEPVLKKLREHKAFAKKLSRALGRGEWSSAKSLEENRPVYTLDHIIKERYPTFVDAVRDIDDALCIIFLFASLPSSAKVSPSLVENCARLAAEWQLFVMHTNSLQKVFLSIKGIYYQAEVFDQTVTWLIPYQFTQSIPTDVDVRVMLTFLELYQTLLGFVFFKLYTDAGLVYPPPLDAKKDETGAGVGAFSLQEAKRIDSAPARKVKEVEIDGKRVSSKDVRQTIKSISATTGDGDVEMPDTEDVTPNDAAEEDFVQQPSTSNPQETSSLHTLKTLASLPQSGSSKLFAPYTFWLSRETSRPVFEFIVRSFGGRIGWPSTSGSGSPFDETDESITHVIIDRPVVEKPDETEEERERKRRRKHIQPQWVVDCINAGRILLEENYTQGKTLPPHLSPFEGRDDAYDPTLGLIAEDIGMDEDEESEVEDAIEPEETDEEERPEVAALKAAATAEDATALRAAELEAEAAGVDFGTFEKKAKSARKKVKAAEAQPLPEGEEDMNKMMMSNKQRKLYARMKYGEKKRTEEREDLQEKRKKIEKEKKRQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEI9</accession>
    <name>A0A2R6NEI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001314">
        <property type="protein sequence ID" value="PSR70807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEI9"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="10751" checksum="920A09C6EBBFA1DC" modified="2018-06-20" version="1">MEGHGPGYAVENQMNQGYRQILSLISGGASLPRLTGLGSEDKPGGKDSVSLVVLKENEIQGALRLFCRIGMVAQFRQTTYDLASAGWRDLCRPPNLESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEJ0</accession>
    <name>A0A2R6NEJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001330">
        <property type="protein sequence ID" value="PSR70751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEJ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NEJ0"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR70751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="341" mass="37978" checksum="F4278403ACB57762" modified="2018-06-20" version="1">MSAQEIQKTLSSAHLHIVDAQSQFDERTSSADDSLRLPLAFTSDTKGLVDPATVSLDVSAQLAFFRKLKYQYLEQKAKDQYIKIIVSDDAPSITAADNELQRQQNELKKQDLKEEKQALAEMHSNIRTLAPLVEQDYNRAKALTAEAVTLARNILDARLAVTRLRQAYPHPRLTVPSAEAQLEDQVADMQNLEDTLQTLNGKIDAVKNRVKTGARDVERMRVDRADLEKLVKKSRSDVDDARVVGLYDWYTASLNLHKSFYSLESSRSASENELHLVYSLSSARRKLHITLVFVPNTCQLANAQISGMQSDTNDLVGAHVAANNVPGLIAAVLARARNELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG86</accession>
    <name>A0A2R6NG86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG86"/>
    <dbReference type="STRING" id="98765.A0A2R6NG86"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="93"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR71268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="275" mass="31164" checksum="0B6F149EA938EC44" modified="2018-06-20" version="1">MSLRLALRAGRTARTVPLRQAVAGAAQIPRFIHSSSSSKASASPFTEPTSPNPAVTKHAETTEALHTYGSYLTQCLPKFIQQFSVLKDELTLYTAPSGVIQVLTFLRDHSQCQFKSVMDITAVDFPEREKRFEIVYNMLSVKFAGRIRVKTYAGESDAVPSAVEVFRGADWYERETWDLFGVYFNGHPDLRRILTDYGFEGHPLRKDFPLTGYTEVRYDEERKRVVYEPLQLTQAFRNFDAASPWEQVGEGVTPKRPEELKHVPPPPPPPAEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGE2</accession>
    <name>A0A2R6NGE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGE2"/>
    <dbReference type="STRING" id="98765.A0A2R6NGE2"/>
    <dbReference type="OrthoDB" id="5946233at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="283" mass="32360" checksum="4332EDE2271F87F2" modified="2018-06-20" version="1">MPLLTQSDPGTENNGIANAQTLLRHRHDPSLSDSLQHKFKGNKGNIKPEIAWRLLRQTFTPGFEDLLELGVSEGWYDPDNTLERLVFHYTFIPWLQRELDGYVALTNDSKPRYNRHKVLPHGRPIEIFRHPDKYGTKDFSVKVLKAHLDEVRSKYAPPGHPVFHLVPPAFEEKARQFYGAIGPPEINRNNVWQVYQTLLEHFRSIQGQDDIRSGIADRAAMPTVGDDPMGEEYMEVLPLKPFRVGNRLIADLEDLNSESSEEEHDPNIWTDPDTSSGSSMVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGE3</accession>
    <name>A0A2R6NGE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGE3"/>
    <dbReference type="STRING" id="98765.A0A2R6NGE3"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="72"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="205" mass="23088" checksum="9B67B6BD8E34F9B3" modified="2018-06-20" version="1">MSGKGDSGRSYHLKCTGDALNTAQSHSGPKDLTLFGSCFCPFVQRVWVALEYLGIDYESSCYDDKAQPAAPNLRDLALIRLQADHVNRTLIPAFYRYLQAQDEEQQIEGGKEFMSALDGLVKLFERSDAETETNIGLWKESGQLGLADVMAGPWIFRATNVLAHYRGFSVPEGERFQAYVERLVNHPAFKKTCSTKDLYLESYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGN8</accession>
    <name>A0A2R6NGN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001275">
        <property type="protein sequence ID" value="PSR71511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGN8"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF17">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53458" checksum="B0A5E28F0FE3F640" modified="2018-06-20" version="1">MAVIKLPAIYTFATVGMFSAVSNLGAGGTQDVALSDESQGVLYGMFALAGLISGGINNLLGPKLTLFIGTLGYTLYVGALWCLQTQGGTRWFLIFAGAMLGITAALLWSAQGSIMMSYPLEKDKGKAFAIFWAIFQFGSFIGSVIALAINIEKGGLDAVSTSTYIAFLIIIFVGVASAFMILPPNRIIRADGTIVRLDTTTKVREELVEMFRLLKNWRMIALFPMFFASNYLYAYQGSVNATVFDGPTRALNATLEGAGAITGALFIGFCVLDNKYMSRRNRGYFGLAVVASVVIVVWSVGLSWQVTFGRDYVAVHGKPINYHDPNYKGKGALFFFYFFGDACYQALAYWIMSALSNDPFTLARFAGLYKAIQSAGAAGSYGMDAMLHPLLNEHLASWSMLLFSFPLAFLVIRSIKETNYEDEKVFYVDDIKKDEMEAAVSDSQEKASLMVIIMRISKAAGNPIEQPRRRALFSHSVTEIFGSEQPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHV6</accession>
    <name>A0A2R6NHV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHV6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16421" checksum="B26C509A1566A70C" modified="2018-06-20" version="1">MWPWDGLRYTYDSHKLFVFLRFFYTHASPCAHSLRMVRSKRMRPEDNASRVIANSVVAYLTADNTPANCINHCISLGYNPSLVSNMVTSAIAVQASCLALQRTQGSTRLSAMFVARGTVNTPVVDHGLSNFTPVHRRQNSYLKLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ72</accession>
    <name>A0A2R6NJ72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001190">
        <property type="protein sequence ID" value="PSR72419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ72"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ72"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="25788" checksum="29CD2C4FC9EE264B" modified="2018-06-20" version="1" fragment="single">MSTPARLSEETIINLTENGVHIQIFLDLLKLSLESRVDRLMTWDGPQGLFQLWREVTKEGSIVSARLAREEAGSARAKGYVYEDRYADEGYEDEDDLFAAASSEHSTAWWEDPVSGCPSGLEDTVLYLLDAGFQPDSCQVLAAKLQDVAKKSLKSCAERPMWRFETRRSADKELLKDSYRPSLSNIITGEVLVVAVHHTALRNYVDVIVVSTKGHIVNGETLARHIASMTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJL1</accession>
    <name>A0A2R6NJL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJL1"/>
    <dbReference type="STRING" id="98765.A0A2R6NJL1"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="60876" checksum="79C65A82986A15F7" modified="2018-06-20" version="1">MAHLRLNLPGLRLEWAYVSLKMSELIAVRYTAPSRQWKRSFGSALFECDDEYWINEEDPKLAFKQPPGKPSIVAYFNCLLRLNMIHAFALRTIYSINKSKVLLGFVGHQWEKRIVAELDSALSKWMDSVPSHLRWDPDQESLPFFNQSASLYASYYNVQICVHRPFIPSPLKSTSLSFASLSVCTNAARSCVHILDVQFRRCDTAPNSYQFYRSIMPLFTAGIVLLLDIWGSNLSGSKRDSARKMVDVHAAMKVLKGLEGRWHTAGRLWDIMYELANVADSVPLPAPSRPPISKRERSSDSSLSTSSPMGPYTASGFSSDTRRLIAGSMRVSSAMQQQTVHPSSQNQSLTSPSVQNTSNNTNSSTGSSIPLSAGVSLPMNSGGFGGLPLYTTFGAGSTITSGNNGWLAGALNYTHPGSSQIQPAPKETIPAILPEAMLGQSFDFDHRASTLVHDQEIVNQAASLPSTQSPFPQYLPSIDPQQASLPIENFDDLIMSLGNDGAMFEEEHGVPSIWSTAPTGFEWDDWATYVNNLNGISKGAQNAPSVQYESNWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKG7</accession>
    <name>A0A2R6NKG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PcRGLX/YetA-like C-terminal alpha/alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001127">
        <property type="protein sequence ID" value="PSR72857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKG7"/>
    <dbReference type="STRING" id="98765.A0A2R6NKG7"/>
    <dbReference type="OrthoDB" id="4798501at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048331">
        <property type="entry name" value="PcRGLX/YetA_3rd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21346">
        <property type="entry name" value="PcRGLX_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PcRGLX/YetA-like C-terminal alpha/alpha toroid" evidence="1">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="99" mass="10790" checksum="243A9A599C17D985" modified="2018-06-20" version="1">MVAINEVLLRLADTDSSLQKDIPGFQFGLFTGNGAPVGWDADTAHLVDEGGTGDGAYDLMFIFAGGEMFMELMDIITDEPEFDAAWLDFCRLYNASNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKL1</accession>
    <name>A0A2R6NKL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001125">
        <property type="protein sequence ID" value="PSR72924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKL1"/>
    <dbReference type="STRING" id="98765.A0A2R6NKL1"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="113"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="325" mass="36341" checksum="1ACF58444676CB4F" modified="2018-06-20" version="1">MVDISKQALKWISEEYYGMYKFLETIGLERINNCPVPKATTRWTDEYLAKQCGESPISVAVTPNGRADAITRGPDERLYFAEPHVEHMSMAEFLVRLSSGHDSQSTDSEVVYLQSQDGNLFSSTPDVESEFSALSSDVPKDLPFITEALGSPPEAVNLWIGDSRSVTSIHSDPYENIYSVIRGSKTFTVFPPTEGWCMEERIYPHATYERSPETSELTLVPSPSSAPPVRWSSIQDPTDADSLPSEAHPIYITVNAGESLYLPAGWWHYVRQSEMTIAVNYWYDMESRGMSWVWLNLLRGGGKGNSPPPGNEGDEFVDSSDDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKV6</accession>
    <name>A0A2R6NKV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v11124</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKV6"/>
    <dbReference type="STRING" id="98765.A0A2R6NKV6"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="722"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="501"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR73020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="971" mass="108449" checksum="4B017EB82867E597" modified="2018-06-20" version="1">MSTLLSFHKSILEKTHDPATSELLLIARGLGLRRVSCKLLQIYDSPQNLVILVNASQDEASAIGEELGVMGCRKPGLRIVGFETGRKERQELYKKGGLIAVTSQILTVDMLTSDIPTHLITGILILHAERVSPSSSEAFIVRMYREKNKSGFLKAFSDQPEHITSGMSPLRTIMKELQLRTVHIYPRFHQDISECLGRDRSVLQLTVDMTENMSEIHNAIVQCMSTTLSELKRSNTSLELDDLNVENAYFKSFDAIVRRQLDSVWHKVGPRTKQLVNDLATLRRLLNMLLSEDALSFQQYLESLIDSNTYNEAGNARQNQSPWLLTDAANVIFQYAKRRCFTMSRAPQQSAPPPQVDDVEDEDAWEALYELEGVRIRKGAARQDKRPSWLPQGMEPVLEELPKWSLVSAALEEIEEEMMRREATLSSRDPGTNTVLIMTSSLRTAELLREFLASIQSDSSPGAQGRKMMQRRLRRYLEGQAMRNVDKKGKQSSHGHVAAAIVEPPGGNDRGEGEVSAALRKKDRDKQAKAASRRRLRGGAPAVQPSRKPIEIQDDEPLVLLPEQFDVDAVLGAFPEPTAMLDFGAEFDPDYGLVASEQTVIVRAYSDDGDDHILSELQPRYIIMAEPNLDFVRRVEVYKKSSPGLGVRVYLMVYNLSCEEAKYLFGVRREKDAFERLIKERGSMLLPIMEERRLSENADSVIKTISTRIAGGRKEVSAEPCQVVVDMREFRSSLPSLLHATGTVVIPATLTVGDYILSPDMCVERKSIPDLISSFNSGRLYTQCEMMSAHYKHPILLIEWEEHRSFSLEAVAEVKSYAKPKYAAKNKAPTAASTETTLPPSSTIQSKIVLLTLTFPRLRIIWSSSPFATADIFNDLKRNLPEPDASRAVAVGAEEDAAADASGGAGVHNVAAEELLRSLPGVSARNVRHVMNRVGSVREFCGLGRGQMQDILGVEPGKMCWDFIHRGDRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL60</accession>
    <name>A0A2R6NL60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001104">
        <property type="protein sequence ID" value="PSR73130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL60"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48358" checksum="F02B730F526D749B" modified="2018-06-20" version="1">MTESSLLNDDVCIGSGDSLPSPRLPPELTDRVIDNLHDSKADLRRCSLVCRSWLPSSSFHLFHYLHIRRDPDSNFDDQSTFNAFITLLQTSPRVYSYLRGLSFESKIPETGFSNRRGRMHLRTLEEILDILPNLLHLDLRLSIFDPTNGVPNRVARGNARKLKTLTFTGVCFGPTPSLMDVLGCFNEVDSLILRDSNYAYYENVTPVIHHASSRLRVRSLSFECALLGCFQTLKHRLDCSSGSLTTLAVDAASVAVASDLEAALQDIGSSLLHLRFCYKSQYRTTFLSPCTRLQSLNLTWGLGSGYDRPMKWEGCMAIIRDGNLSSLTHLSLILRCYVYTTSVGHDPEKWSPTDSYHLESVRWEMLHEATSRCTLLRSIDLDFDLHGLKGHMAGKHDQYFHFVERLKGILWRRMPEPTRSLLKVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM72</accession>
    <name>A0A2R6NM72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microtubule associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001105">
        <property type="protein sequence ID" value="PSR73122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM72"/>
    <dbReference type="STRING" id="98765.A0A2R6NM72"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="88717" checksum="A0B8707987CF7D9C" modified="2018-06-20" version="1">MSTTITSLLNSLHTHLQSQTQLLPALHNQLGLPPTALADELSTLQKQLTECVESQIALRRAQVDEWMCKCEEVEKDCLRYSKALGGHMKATGSSVGEVRKEQVLPKRFEMITEYQEKLRQLYHTKLEQLLTISNRLAQLSRTLGPEFFASDILEPSAATGESEIDPSSNRDVTPERFSKLEKELVRGKGEVSKRLNQLSATMVQIDWLHTELGITPPSVEDLTSPASSTAFLRVPSISRPPSSCSSLTASTSSSSDPFLTSTPTPMTRSKTNTPFLLISSSSSSNDSPPSSESEHIQYQRIFSRFVARVEELTDEELADANKLSIGLEGVDPSPGLVSWAESTRASLEDLKRKRETHIQAMYDQLEALWRRLGVADKDMDAFVEAQRGSTEDTVRAYEEELDRMLDLKRERMSTFVENARDEIRKLWDELMIGEDERVDFAPFADDEHTEELLSIHEEEIRRLKEDRRAKGSLLAGIKKYFDICEDEKELAASASDQTRLLSRGPRDPGRLLREEKMRKRVTKEKPRLEQDLLSSIPAWEAEAGRVFLVHGQSILQILMNATGANEKENGNKRGKSQTRAGSVPPRSKTPSNAANNLAPVPNTTHGARNSRSATPAMRPSTSMSSSRSGPSRRAKLGEATTSYNNAPPVPLVPPVGHVALNKSNGPAFNRPPSPSSKIPSKTPLLSSLPRPVPIAMPVPRSGSQHRTLGHGRAPSSHSHSYHPYPRTQRSSSSSSATSHRVYGAMALNTQMTAGAARKASRVRRESFKPRPSMDDGWNAGGGTDKRWAGFAGGAVREEEEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMA1</accession>
    <name>A0A2R6NMA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001073">
        <property type="protein sequence ID" value="PSR73503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMA1"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="262" mass="28961" checksum="3837D0A8614AF2E6" modified="2018-06-20" version="1">MPFLSEIGTWILSSFNSLLPDCLVDRPTSHAAHDWGTNRLCQTVDRNDVSRVVLVIEAAVHYFRHLRSSTPRVSELQLRSGITVEFLLLEECEEVDPDTTLKLIVPDKTGKNLLVNGEVTVLANGSETRLYGIKITSSLKHLLHCSVFFFDSDFSVISYYQPAVGGNPDPPLDSQGEGALTIGFGAGSSQPQLYTLQDGQDFDLGFLKIFVSNVPLDLSHIPRESPFESTGKAPAPRGAHTRERTKASLWDTIVIPVKQRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMV5</accession>
    <name>A0A2R6NMV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v10682</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMV5"/>
    <dbReference type="STRING" id="98765.A0A2R6NMV5"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21773">
        <property type="entry name" value="MobB_CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="112"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="417"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR73390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="485" mass="55394" checksum="2EE54CE929FCB555" modified="2018-06-20" version="1">MQTSQSSTSGTSGQTSNSAKSADYVYFDRTTAGFSDDAVPRARTAQLKLEHYYKIAVDAAIERNTRRVELERKLAGDATMTDERKQRQLQQLGKRESAFLRLRRTKLGLDDFRTVKVIGKGAFGEVRVVQKTDTGKIYAMKTLKKEEMLKKDQLAHVRAERDVLAESNSPWVVQLYYSFQDPAYLYLIMEFLPGGDLMTMLIKYDTFSEDVSRFYIAECVLAIEAVHKLGFIHRDIKPDNILIDKEGHIKLSDFGLSTGFHKQHDSSYYQRLLDSASGVQSPTTAARNSVMVNAIHLTMSSKDQIATWKANRRKLAYSTVGTPDYIAPEIFLQKGYSNECDWWSLGAIMFECLVGYPPFCSESTHDTYHKIINWSQYLMFPDDVHLSHEAEDIIRRLITSQDRRMNVEQIKHHPFFYGVNWNAIRQIEAPFIPRLRSITDTSYFPTDELEQVPEEPVAGDTTGANKDLAFLGYTFKRFSISSSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNF1</accession>
    <name>A0A2R6NNF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001047">
        <property type="protein sequence ID" value="PSR73937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNF1"/>
    <dbReference type="STRING" id="98765.A0A2R6NNF1"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34464" checksum="B3A31FB66E2B0BF1" modified="2018-06-20" version="1">MSILSQFFPPKPKWIAKDMPDMSGMVCVVTGGNSGIGRETVKALLKHNATVYIFARSPSKARTCIEELKSEADKEAGFVELDLANLASIKTAVSEFCRGVMIPPIEDLTADGYDLQFGVDVLGHFFLTQLLLPLLLSTASSDSNPTRKVRVITTSSLGHLFTPMNFEALLDRSSSGGEGEEAAYEEKVKKVREKMGPQNLYMMSKYGNVVFASELAKRYSDQGIISISVNPGNIKSDLMRNASIVQKIMLKLLLYPTEQGAITQIFDGTAPEAADMNGKYLIPFARVGKARVDALDPVVGEKLWAWMERQVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNN7</accession>
    <name>A0A2R6NNN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001026">
        <property type="protein sequence ID" value="PSR74051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNN7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7559" checksum="B10184F8419638E1" modified="2018-06-20" version="1" fragment="single">KSASASVFYANYALFKAPNSIRRSVLPTLHIYYNDTTRPIIIEGEHRSAPYATYDTLYVRRFFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPS1</accession>
    <name>A0A2R6NPS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000983">
        <property type="protein sequence ID" value="PSR74505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPS1"/>
    <dbReference type="STRING" id="98765.A0A2R6NPS1"/>
    <dbReference type="OrthoDB" id="3254160at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="430" mass="46082" checksum="C1F7DB8AD7A07F20" modified="2018-06-20" version="1">MAEGAGHYIRGVAREVVERLTPAIRKSVNDVLLPTIHQEYQKIRSGAVPRFEYVTELDSIGCTMTLQLVPQPTPEQHRQYTVPPDYRNRADARAAVIVLAVEQGVVEFLRFRGQPVPRDYVRYYLQPTESLDGRNGKKRSHADDSEGGRRKMPRLNNGMQGNRRGQNFHSGQPRSQGPSWSNQVAFPAGNHNGLWPAPYAYNNGGAQPSAPSHSGYDTNPAPFGSGPPVAHVGPPIPLTSPIQSGGDLAVYYASLAANSLPTLHHTNSSNTTPYAAGTAYSQYVAPPASSPAIPGGAAYTSYPNASYTQPFQLCGSAQQQAYTPYAVAPPIMYPTVAQMGPVGTSGISSFAAPIGAWNTTAVPMQGVQPSSTPNSVSHPPQNGLPNDTQMENQSPLQRARTAPTAPNRAGFKKIQVQSAPKSSVTELYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ42</accession>
    <name>A0A2R6NQ42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ42"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7463" checksum="5EB0C339EDBA62F5" modified="2018-06-20" version="1">MAHSTRITGMRSEAHCKDLDSHATGITVPHHDADRKPLAEHEPDGQTAIKKGAAKGANDLHDVEQFNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ72</accession>
    <name>A0A2R6NQ72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ72"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ72"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21742">
        <property type="entry name" value="MobB_NDR_LATS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059233">
        <property type="entry name" value="MobB_NdrA/B/Cbk1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="405" mass="45318" checksum="07EA11AFFBF374C2" modified="2018-06-20" version="1">MAQPRRPLPTPPVLSHASIYDRDDTLMGLHSSYPYPNYIPPVPSPYPPFQDTQPQDTDERNTLRGGTLLHKGFYDLLALIPSTPSPSRLFWPRQNAEPLAGPRYEDIAPDSVPVVSAKDSTLPNSPPPAKNLKGRRISKDMVSRPTGFVHLVHASDVDQAEALLSRWGPEGQGKLGDPRWADPIKNQIRKLHQAQAVNEVVGTFKVTESTLSRADKQLPPLRVVNGISTTTSSTVTTAARENIPLTSGLPSPTGLPGQILIGQPGNSTLRWTTGLPVHHEHAEEETPGAVVLEPDLPVPPQPIRRKPIIPSLATLEKAVAARIYFENLYFPLLRHVPSREQRRIAMEKDMMNMQLNEEHKEYLRARWRKNETDYLRERRRKVDASAFGKKVTFEPSETFSSRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR03</accession>
    <name>A0A2R6NR03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v9395</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000940">
        <property type="protein sequence ID" value="PSR74981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NR03"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05579">
        <property type="entry name" value="STKc_MAST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000580">
        <property type="entry name" value="AGC protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1421"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1692"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="810"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="964"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1205"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1302"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1462"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1540"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1811"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="818"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="964"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1467"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1497"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1548"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1571"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1610"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1643"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1824"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR74981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1843" mass="204016" checksum="6E4A4CE23F120118" modified="2018-06-20" version="1">MPFVRRHVYRRLKAAKQECDKELQRVTNSVTAFFEERLRDNEHEQEYEREQRELERERDRDSHQSEIVDALREGFVLQPAELRSALQFDEVSDGGYDADPEGSTRGRQPSISSNSPASYSPASIRRHPTLPRENRSLTHLPLTVGGTISPASSATPPPEVISPRKRDNTTSSTGSQWSGQSLASRRLSRTIHIPSRPSRSGASSRSTSRSRSPLPRSAFPDSSASMNNRRSSRILVDDPIDPIMTTLYEIIGVATDVVEMSISQLTAQPKICEQLVQRVQNIGKAWDEHPDWHGRNWYVQVLLAIASLSRVVEWWEAEKQFWNFDDNDDEQEEPLLFVMKPADEETAAVVPATPSMKHGMAETGSAVKVGADEEAKLRMYRTTSASRRSRDDAPKELSATPAHNTHKDPDHPRSMSKYDNAESARVLATERLRLQAETAQNQNIVLELSLDGDHFVWVNYAWRNVIGGDPEDLIDTRVSKLLAASDWHVFRDATRRLMEDDSHTVEVRFKVMLDPDFDRDHTQPALYQQMEGKGMLMIEREDGRPSHTMWVVKPISSPEYLQAPPSILLETGEIGDEPATPEPTPQVGFSDRCPNEPVTPFPFARPISTALILCRICECNIPQWYFEKHNETCSEVHRLEAEIGECNESIGELRSTIRELQTAMDRSSPMSVPEYRGMPIFSPSTSPSSNSPLALLRAPLKMKRMSVKKMQRQVLEQLEDILSLSAEVKIPSLKEDEAQEPIERQRLLSPASERKMSQVRRWNKPSIEDQALTQLVEDAERVMRQKIDNVVRMQNTIRYSEKIRQEWEEKVEQTLSMGDDEESDEEEEEEEIEGEQEEELSEQHTLGSLRETEDDHSSTTSEYAFSGHNASSDPTPLAPSPAPYAETLERSESVASMASSVPAPVPTYHWPSSTFNTRSSTPSSISSPLALAAPIIASSCPDDIPPPMDLNDGHSLPIPMPGVSYSQRPRRSPQNLEPKLLITPPLSPMVSPQDVTARRANRRHSTAQPLISPTSSISNINSMPLSPRLPSVTPVSRTTPTSIKDFEIIKPISKGAFGSVFLAKKKVTGDYFAIKVLKKADMIAKNQITNVKAERMILMKQAESPFVAKLYFTFQSKENLYLVMEYLNGGDCAALIKSLGSLPEEWTRNYIAEVVLGLESLHQRGIVHRDLKPDNLLIDQHGHLKLTDFGLSRIGLLGRQTRDGPLLFERGPRSRPRHNSRPPSIDSYMSSPLLAAELHGSYFAQRNQSIPRPGSSPYLPLSDDVSESSGSESVYNLFPRRNGVKQIGDSPLQSFATELTTDLRSHPTPGGTPPGEQKVVGTPDYLAPETILGLRGDDAAVDWWALGVITYEFLYGIPPFHDETPEKVFENILSGHIEWHDDYVDVSDEAKDFMARLMTLDPTHRLGANGAVEVKAHPFFTGIDWNAVTTTEAAFIPQVTDPESTDYFDPRGAVLQLFNEEDHPIPTSGTFSDSPSMTPEATLQSTLTAPVPLPNRDTTSTSSDDDFGSFSFKNLPVLKQANDDVIRKLRTDQLAPIVHTLSEPSGAHSRRKSISTRVKKPTSVITAMDMSTKSSSGGPPSPATSTSSIASSPSRGPPTPGSAGSIHARKPSDHGAIERFKLNHLEGDVHRRNSMPSRLRTASISTSGDGSQSDSWSGQISQHPGYEVHTPPSSVASIDLKRAPDPHDRAVTCLLAEDNPITAKIIETLLIRLGCRCVVVADGSEAISVAMGDIKFDCILMDLHMPILDGEGAARYIKTTNNKNASTPIIAVSAYGASEPTEQNNPFTAYLAKPVQKADLLTVMRQLGFKTSTAPGRGPANARTTGAATSPTSLSLSTGVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRH5</accession>
    <name>A0A2R6NRH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NRH5"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42464" checksum="A7C417E4AB31DDE9" modified="2018-06-20" version="1">MPPSRPVPTLPPDFTVTATSQLTSLWSNYGHTYRLHLSSQPNSLILKSIHPPVLDHPDESHLRKLLSYDIERWFYHSLAKHVPPTVKLARPYPVLTDNEHNLLLEDLSVEFPFPARGSLGREGTICVLKWLAGFHGTFFQIYPARGSNGAVPPLIPPPNKWKQGSETAGIWQRGTYWYLETRRKELAEINEEEYGWLLPWVEKVNDAVDREIHRYGTLVHGDVKGENIVFNQDLYSRRKGKPAAKAETSTELKCALYDLQYVGLGLPALDLVYFLGTSVESSLLSSHTDEKALLETYHAVFLESLSSSTSKDGNDPMYDFETFWKHWEFAIVDWYRFMAGWGFWGNDRWTERRAREIVMKWKAAKVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRN6</accession>
    <name>A0A2R6NRN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000900">
        <property type="protein sequence ID" value="PSR75434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRN6"/>
    <dbReference type="OrthoDB" id="3260094at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="195"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="466" mass="52814" checksum="B15C881B711401C3" modified="2018-06-20" version="1" fragment="single">MDGRSTSPTASDITSVNSESPHCNGCREDSDAAWRCLRVAEGMAKSLTTCSVDAWFRQYAPRSLTRWSDSDIDGILRILEETDMLKADGSHISTISKAVAQHIKTTKGLSPTTRIEYTPHECSVPEVPSYAWFPNVRSTLIESRTIDQRQRQSGSVEPTAYESMAPESGQPQVPQAVALEKARLNTRDDGKSERGEEQKTGMNLSDVAAVGEVKRGEGQSDRRDNELKICGGATELLYNDPCRRFVNGFTIERRRMRLWRFERTHVCVSKEFSFHRTPRSFLRFLLYLLFSSPRDLGFDPNVRRYFQRVPEETDPSSGASSDRYEIAYRYQVGNRYFLTQGPPISDQAAYWVVSQATRVWRVREMHFPDPSNEHEYTLGEPMALKDAYLLEDAVLDSGIKEQIMGSLRDAGADDKDAARYFMEYEIDEVALLPNENETGLEDDLTSDMETNKPASYTPKVETPDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRV8</accession>
    <name>A0A2R6NRV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRV8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="235" mass="24711" checksum="C351411AD93A026A" modified="2018-06-20" version="1">MRAKGIPMEPLTLEPPSLEATSFVGQEKSTSPCSLRLVALDIDDIINSPLHGFSSQPDTPISVPVLSSSSRNALGDARYSLESGEHCFSPASKQSEPFSALTLCSSPSSHILAPSVTSSPEQPCSNSVPCSIPVAKPNAIIPLPTPTAKDIASVKPLKPFASFLDQFMETARHATLTQESKHGLSLGIVTQYLTSIISHITMWNYPGQDGHSQGGFPLPNAGGPNYGPPSGPPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSF8</accession>
    <name>A0A2R6NSF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000902">
        <property type="protein sequence ID" value="PSR75422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSF8"/>
    <dbReference type="STRING" id="98765.A0A2R6NSF8"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="45043" checksum="E1CAD2182DFAA131" modified="2018-06-20" version="1">MPPSVQCGGQTEIISHDEGQAEILANDKGRAFQTINNHKHAVSAGDAAKNAYHSNPKSTVFNAKRLVGCKIDDPDIQRDQKHWPFKVVKKNDKPAIEVEFKGDKRQCSPEEISAMVLVKMKGTAEAYLGKTVTHAVVTVPAYFNNAQRQAIKDAGTIAGSQVLRIINEPTAAAIAYSLDRKGGESQIIDLGGGTFDVSLLLIDDGVFEALATAGDTHLGGEDFDNFDIAYFVKLYRTKTGSDVSSNLRALGKLKHEVGKAERTLSSQHGNDFSETLTRAKFEELNVDLFRKTMKPVEQVLKDANLKKEDINEIVLVGGSTRIPKVQQLLKEYFNKEPSKGINPDEAIAYGAAVQGDILSGDESLGDAVLVDLTLGIGTTGGVMTKLISCNAVIPGHHHEREGRVLVIGSTMSDCCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTF9</accession>
    <name>A0A2R6NTF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000849">
        <property type="protein sequence ID" value="PSR76346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTF9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="5799" checksum="F124B55E3DC5AA41" modified="2018-06-20" version="1">MGSSGSNSQYSGEPKHTLRNRADVSGNNAYDGSTGEVDIVDFNSTYNSENPSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTH4</accession>
    <name>A0A2R6NTH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v8475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000847">
        <property type="protein sequence ID" value="PSR76379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTH4"/>
    <dbReference type="STRING" id="98765.A0A2R6NTH4"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015333208" description="Prenylcysteine lyase domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="10">
        <location>
            <begin position="164"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR76379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="595" mass="66163" checksum="0B80D14B6DC00422" modified="2018-06-20" version="1">MYLSTRLLVTYALLQTAAAFQLPFYIPWVSARLDSNDGQIPLALPQETPLNRIAIVGAGAGGSSAAFWISKAKKRYGLDVEVDVFESSSYVGGRSTTVYPYDDPSLEPIELGASIFVKANKNLWRASEEFGFDRKDFDEDDSMGIWDGEQFLLTTSGGGRIGGWWDTLKVLWRYGYKAPTRTKAIVDGMIQKFLTLYGPCFGSRSFTNLTTLAEELGWTEMIGQTTADYFDEQGIDPRWTREMIESATRVNYGQNADEIHALEGMCSIAATGASQIKGGNWLIFDQFLKRSNATVFLNTTVTSVTQVHENKFTLRTRPAGSSSVGPQSESERHYRAVILAAPFHGASIDLSLLPSANASEPQPTIPPQPYVHLHVTLLATTSPHARSRYFNLGEKDTVPGMVLTTWEGVRGRGGGSASASAVSGEGETANAREDGVPEFNSVSYHGKVRTLDGEPVKRVVGDKEEEVWSVKIFSKKRVEDRWLKRMFGNVGWVYRKEWDAYPVLPPTKEFPPVKLGKGFYYVNAFEPFISTMETETIAARNVVELLMQEEFDASICKSDEEAILLTDDVDSLKDFVYGWDCRAKELSYENLELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUF2</accession>
    <name>A0A2R6NUF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000834">
        <property type="protein sequence ID" value="PSR76814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUF2"/>
    <dbReference type="STRING" id="98765.A0A2R6NUF2"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015332266" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR76814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="446" mass="47396" checksum="9EE066CD8A78939E" modified="2018-06-20" version="1">MASWKLVTFLAVAVSCTSALEVRHVRSSRVSAASTTELPTAPFSIALTDKAPRSSYKKQLLRELRSGGKSKTAVVDGSGDDEEYLTDIVVGGQSFKVIVDTGSSDTWLADKGFKCFTLDNSPQPAADCFFGTTGFDTSKSKTFVPLPDTNFNISYGDGEFLTGSVGFDTVTVGGLTVTRQEIGVVTAAAWEGDSINTGLMGLAFPDLTSVYNGSNPDLDGADNSLPYNPFFFSAVQQKAVSTPVFSVALNRGTFAHQANTTFDPDLGFLAFGGIAPVAVTKRSATVPVQGFATSSGGSEFFYYAVDIDALVFPGSTAKTTIKAPTIIDTGTTLNYVPTNIAKAFNARFDPPATFVEDEDTYYVDCNATAPAFSAKIGGVEFAVDGRDQILPFLDENNDLVCISGTQDGGPDEDDTIFIFGDVFLHNVVATFDISKNDIILTERASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUH5</accession>
    <name>A0A2R6NUH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000833">
        <property type="protein sequence ID" value="PSR76843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NUH5"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR76843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="279" mass="31240" checksum="C61A28B7AA05551B" modified="2018-06-20" version="1">MRPVVSYDDLSAPQQPVQQQLGPPLPSTNQPPAKKRRVHQKAPQRRPPQYTQHWDDPGSNTQTMNYDDDVSAVAPGSENAGYEEEEEEQEEESRELTHNEIWDDSALIDAWDSAIAEYEAYHGSGKKWKEEPVKKSPLWYNVPPVEEKKANGRPSRDARIAQVTEEEDEEIADDSAPLNFDTYVPTHDPSLASAIPAHPPAIPGLDYSQSYLPGPPGTMVSQDEAFTRALSAMYWGGYWTAVYHCQRYPQSQEAKGTATQNRGAEGEDANMDELVSTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUI0</accession>
    <name>A0A2R6NUI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000825">
        <property type="protein sequence ID" value="PSR76913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUI0"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR76913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38299" checksum="2857115D20993A7F" modified="2018-06-20" version="1">MSKITPVDERQPLLSPAPLVTGEDVEHDEENIEVPVAEDVPKKRSWWSIGWYTLLTVFGILFAVIFIKGFIDADDVEFDLGKALKSALGGGLSGAAAMVLQVLTLMPLRTVMNYQYRYGTNTTAAIRTLYLDGGWTRYYQGLSAALVQGPVSRFGDTAANAGILALLQSNSYMKKLPSLIKTVFASLAAAAFRMILTPVDTVKTIMQTEGKGGLTILKARVKRYGIGTLWYGAIATAAATFVGHYPWFGTYNFLDDHLPPPHNLFGKLARQAFIGFVASVISDTVSNSLRVVKTYRQVNEVRIGYFAAAEAVIAQDGLRGLFGRGLKTRIIANGLQGLMFSILWKLFLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV51</accession>
    <name>A0A2R6NV51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v7919</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="MLYV02000795">
        <property type="protein sequence ID" value="PSR77396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV51"/>
    <dbReference type="STRING" id="98765.A0A2R6NV51"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="15">
        <location>
            <begin position="354"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR77396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="704" mass="76037" checksum="07646D8589DB3E58" modified="2018-06-20" version="1">MDALKNVFEKKKQEGSPALITFVTAGYPTLQDTVPIMLAMQEGGADIIELGVPFSDPIADGPAIQETNTIAVNNDVEYATCLGLLRDARSKGLTAPVLLMGYYNPMLAYGEDKAIQDAYEAGANGFIMVDLPPEEAITFREKCTKSHLSYVPLIAPSTTLHRIKFLSSIADTFIYVVSKMGTTGSSVTGSLNSALPDIIARVREYASVPLAVGFGVATREHFDHVAEAGADGVVIGSRLVSIIKTSPAGQIPQKVEAYCREISLKGQPAKRYTHSVTGNPHSTPETNVNREGPAACHTASDPSVLPARFGQFGGQYVPESLFDCLIELEEAHKSAMADPEFWKEFESFYGYMNRPSNLYKAERLTEHAGGATIWLKREDLNHTGSHKINNAIGQLLLARRIGKTRIIAETGAGQHGVATATVCARFGMECIVYMGSEDVRRQALNVFRMRMLGATVIPVNSGSCTLKDAVNEAMRDWVTNLSTTHYLVGSAIGPHPFPTIVRDFQHIISKEIKEQLNARVGKLPDAVVACVGGGSNAIGTFFDFIGDKSVKLIGVEAGGEGIDGDRHSATLAKGQPGVLHGVRTYILQSPAGQIIETHSISAGLDYPGVGPEHAWLKDSGRAQYVVATDEEALRGFRLITQLEGIIPALESSHAIWEGVRLAKTLPKDQDIVICLSGRGDKDVEQISQLLPGKWEDILDWHVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVL5</accession>
    <name>A0A2R6NVL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rab6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v7810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVL5"/>
    <dbReference type="STRING" id="98765.A0A2R6NVL5"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR77620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23144" checksum="A14B7C67100CCDFB" modified="2018-06-20" version="1">MATSPVTADFTSPPLKRSKIVLLGDQSVGKTSLITRFMYDTFDNTYQATIGIDFLSKAMYLEDRTVRLQLWDTAGQERYRSLIPSYIRDCSVAIVVFDITNRQSFSSTTKWIDDVRSERGNDVIIVLVGNKADLSDKRQVTLEEANAKATELNIMFMETSAKAGHNVKSLFKKIAMSLVGMEKEEAAETQNATPPGMTSRGVVYSAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVV0</accession>
    <name>A0A2R6NVV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000785">
        <property type="protein sequence ID" value="PSR77677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVV0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR77677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="13090" checksum="754FA2D63CB9055D" modified="2018-06-20" version="1">MVGAGRGDWGICSGGGKEDRVLDGVAGDRAGWVGVPLGIGRRPGEKGSLHLPYMGIRDVPRMSRGKEVSDQLAAYQDSLGPFKNAPPPLAPALRFAPFPPPSPTAVTLFSTSSFTASTSRSLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVW9</accession>
    <name>A0A2R6NVW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v7688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000770">
        <property type="protein sequence ID" value="PSR77867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVW9"/>
    <dbReference type="STRING" id="98765.A0A2R6NVW9"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050463">
        <property type="entry name" value="Gfo/Idh/MocA_oxidrdct_glycsds"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43818:SF11">
        <property type="entry name" value="BCDNA.GH03377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="3">
        <location>
            <begin position="152"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR77867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="376" mass="40250" checksum="0B045EE5BF4C7647" modified="2018-06-20" version="1">MAPIRIGFIGLSSRGWASTNLVPQLFHPLLSSSYSLTALSTSSEASAAAAAAKYSELAGHPVKGYHGEQGFVDIANDPNVDMVAVSVKIPDHLKAVTPAIEAGKDIFIEWAPGNGYEETLKIAEAAKRKGVKVLVGAQATHGVYLNKLRYTKYIGSSQIISIAAEMFAGLASESYKYTVDINNGATLLTIPVGHLLVATSHAIGEFTEVSASGAIQYPIALLRDADGKLTGDSIPKTAHDQIALSGILRGSGNNTNAVFASIHVQGGIPLLGEKGRGRTALKWIIDGEDGVIEVLNREEDSPALAFISIKEQQVLLNGQAVKLEEREEDQLDNPGKAWLEFARGGRYWSIEDAVRVHRVLDAAQRSIIEGRKFVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW22</accession>
    <name>A0A2R6NW22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000764">
        <property type="protein sequence ID" value="PSR77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW22"/>
    <dbReference type="STRING" id="98765.A0A2R6NW22"/>
    <dbReference type="OrthoDB" id="3147752at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="450" mass="50637" checksum="F6CFC6AA566697EA" modified="2018-06-20" version="1">MGQREVVDTIARPPLTNGNKDDATRVHREESISEIEVTTGLRASLKAAHDDIMKARRENKRLVAEKEELQDNNGKLRVKCRDLEVVIDRGRETRQLEESWERKCHDYGQQLEEARGVIASLKRELESVQSQQRDKDALLEIRTTELRDAQTLLDRTDVVSHAAAIRMVENLNSEIYQLAALIPDSVKFLKARRTETELARAAYRGAETSIGKELVGLLASLHHSDDPICVQIALQTLLTQSATHIITSWDVRLSDRENSLLERIHSEILLNEPAIISAKWRSLTRRYLRQMSPELDVTPSIGANILSQITDILLTSGVYGEAQNIHRNVLQVFGAKVKDIVSQSGRVGKAISEDITSTHFQVIAPYSGDLFSSKSMEDEYGEGRGNQREQLKDSEMRTLCATQVGLMRCDMRKKDGKVDTIVLLKSKIALESLKQEMMRAEQDNLGSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW49</accession>
    <name>A0A2R6NW49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000760">
        <property type="protein sequence ID" value="PSR78074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW49"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49752" checksum="9CE6FACEC0272E01" modified="2018-06-20" version="1">MAPQWVAPREGCPRAHKDILLPNLEVLSWLDDSFDSETCLRLISPKLKSLHIIHYYWNDDHAYYAALSEIIYHIAAHRIPLNSFTLEVREDNRADAMRAIARVANKRQESTPGRCFDYNLDTALSYLAESINLFEFASPCCLTDSAFAHLARMPTLNILRFLCRGNMKPIQSSGGGFNFPNLRILDLTIESLTEDIVDFFASVQGPSILRLDITIICADPPKSLMHRLLSTMCKAPYHDTLKYLSITVKGHKDSEPPVEREAFAPLFASPFLNLTNLFLAFPSMDPTDQFLRDLAAAYPKLEVLSLLRPGSAPRLMVPRATLDGAHALAVSCRSLTTLALAFNTGPHLGLQARWKAAECPNLRSWCVLGSDIEDNAVEDLSRYLAFVFPNLEKLWTKMPTRDDSDRLLFSRWGDNLSPCGERHPEHEELIVIVEASVVWLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWD8</accession>
    <name>A0A2R6NWD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWD8"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="496" mass="55718" checksum="9E8CCE5846117366" modified="2018-06-20" version="1">MPGIFPEREDTGTATTHFTPHISPKDWNRFQIYAPRIKSLCLFTSDFCNGSDQTSSIQLSYDAWVTLSSCKPPGPLLPNLKQLFWFIPTTTPTETTQAVNMFLGPKLRVFQLQIDIDQADPVIEAILHLPWTSPSLQTLGVGYHNRSLCERSFLGGRHLQGLLGGLGHLQEFRWACVVSPDQLSALLASQPRSLRRLSVGLDDDAWGDEGRSPSLAQRQGETWTLPNLTELELHARSSLTCSNALRMCNFPRLAVFVLSTALFPSPMQVFQTLCDTLSHTTLHTITLKDDYTLAPSGTDSPVLIINPDTLQPLYAFRAMTSISFSEGNTDDYGESRFQFSLNDTAVLELAMAWPQLKSLRLGPSVWDSTLDNYITLKGLKHLVQHCQYLVELRISILVTEPSYFEDTALDIIPTRCNELITKIDFIDSSIGVDSWDVAAYLHVLFPRLVSTEMDRYLCERDEGPLEEVEKCLLSIHKAHLWRSRILERGINITATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWH7</accession>
    <name>A0A2R6NWH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000750">
        <property type="protein sequence ID" value="PSR78304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWH7"/>
    <dbReference type="STRING" id="98765.A0A2R6NWH7"/>
    <dbReference type="OrthoDB" id="2804135at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="425" mass="46451" checksum="002F5C890823CC7E" modified="2018-06-20" version="1">MSTPKGMITNWREKISGNSTSSPSLHSSSSSFSLAGGGAASDASVSQASTPSPSPGMLISSNATSSIEATRTLVLKSTATTRDTSLMNVVVNTTSTSESAAKAAKEKPETPTLISNERTPAEPERQRTARSQRKTPATSDVPLPNIKNSRAIWRGQVVPSYISFVATLDNPWDADSTGDEIDALQQSWSTAFPNHRVLVRPAASIHRVATQRLYEWRSNIGKRGIAAVEWLWEDKGLAHEEERRDYVATHLGPHFLCMYKDEINATGAFRAEVLMRTFGSYLSLCDPTTGSIVDFGIPIGALAMCAAAVERGLLLYRTGKIQTEKEQQDDIKSALDKGDAKLAKDLKAFHAKLRTFSEGSWSKPTQDYVKVMTKLSEVQWGRIMRAGMKHVKQSKGSLKIPEEEEDERAMMIVDSDDDGYSGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWK6</accession>
    <name>A0A2R6NWK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000740">
        <property type="protein sequence ID" value="PSR78457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWK6"/>
    <dbReference type="STRING" id="98765.A0A2R6NWK6"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="844"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="102648" checksum="B2734CF0F6B587EA" modified="2018-06-20" version="1">MSANPPVSMNEEPWEEDVFDEDADGDVDYTESSGEEYSEEETEDAPGSQEGKGQDRDVGEPEQEVDQDFDRLVREIRAGDTSAGALSKVWDFDMKDREAEFKDDLREASGIGRKRGRKPGRQRGIILSPQVRALIGEGNQAYVDNDIPSTIRIMQEVIRIEPRAGSAWSVLAQCYDDMGEREKALQLRIMAAHLNQDPEEWLRLAEQSRSQGYHQQALYCYRKLYQLDPSNVNALWDRASLAKEVGDLRTARHAFLAILKRVPHDLSVLAELRPILIELSDLELCASLFQDSFTHHQATFPTGQVSNLSAETSRTDHAFDLMEIFVLADLYNTLGQHEQAIHTIRKGCRWLQGRAAQKFWDSCEDDREWDVPAGSNTSTTSGGRTVSDGEVQPGMYPLDVNARHRLAIARIKMGDMTEGKIHANIVLAQQIGEYAALFSEIADAYFEREMYAEAGYIYEMLGADGGTSSLYVLLQAASCRRMIGDIKEAAEVYEHVIEADPTHNDAKMKLAEIYEILNEPRRALDLVLQVIDSRRKIRNGGRQDQEGENMTSAPDASGTSLFEEKSRLGKEKMSRPGPKAGKLTLPQLRELEASKEKDAVLSYGRVKELWARMLAGDMQADREWMHEAESLVESFRETRALFLTTRQAGFRGMFPRAKKRKQTEEATEDSMASRLQLELGRDTLTKKSKSDGVSQNMNSFRTISFDDWLRLMMQYAFNLTERGHYDDAQDLLRHIMYSNGFQKRSHQDAIRCALMTCSITVGRHDIVVEQSRKLVNAHQFNNEPLRILVASLASGLHSTDAFLASTLSKHMLRELRAHDAALKNPDGLRWNPVLKRYGVGSKVDDDEDEGIDAGHAGGETVGKEGQDTTGAQGEQPRPRLPTKENPVGVAVYGQICLAAKSYQSALIHHLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXF7</accession>
    <name>A0A2R6NXF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000707">
        <property type="protein sequence ID" value="PSR79161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXF7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="58" mass="6411" checksum="F9545A7E0EABDB64" modified="2018-06-20" version="1">MTLHAYGEGLGATHPDHRAQRGWMVGMKPGETLMSGMGQNYAPVVGHWMKRVTESQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXN5</accession>
    <name>A0A2R6NXN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXN5"/>
    <dbReference type="OrthoDB" id="2757285at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="549" mass="61640" checksum="11786A489F2119B8" modified="2018-06-20" version="1">MSLLNQLLRSLPAPGRRSSQSDTLAMIRIRHVSPKQHDSGGVQRRGRDVKRHESTLLATELLVEILSYLEHRDLIRCRKVRASLFFLLIWTEGFLSKVSSAFKQVIDGTPLLQYIVEFGAAGYTAQRSTAADMLKQHHTFRSIQRAWRDPQPRCIHSEHLVLTNSLAWNVGTAVAFGGILLGTVRGDHSGELLHTLKLEPGPNSHRTLRFNHRVLRFLADGEQDLLVLVSWTMMRFISLSKSPKPHKRAGKEFVNIESYMAGLNLDDIRNAVVSGDWVLLTTVRKGRDSFMLCHWPSGEMLTRRSQADVLNHDAHLVNGYLLICQSVMDPIFCRVVDTLEVYSPKIGSRTTNRLQLHPLARLELPQTTLLSPNAKHPALRRIPSCSSPGLVCVSLDGGSTREWDLYVPLHTVLLNSAKHAGASYFVPWNAWGLFSRQMTTRQQPCAIVGLRVIFQDTICDFNPVDVTRNIYASVDTASGLVCFGPTIVPENANRKWSIASHPYRQTMLRLPDVPPGVWFQQSIFQDAVSGPKVNTLSLPESRAHRLNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXY7</accession>
    <name>A0A2R6NXY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXY7"/>
    <dbReference type="STRING" id="98765.A0A2R6NXY7"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="120" mass="13255" checksum="1F738194045C06AD" modified="2018-06-20" version="1">MNATYAKNLASLSKLVLVLFSKDTTVVPKESSWFGSYAPQDKDGRSSTVGEKTIIPMRLQTVYTEDRFGLKTLDERGDVLLETCEAEHMQITPECLQPLVQKYVGGSLSSSVPGDLLRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY06</accession>
    <name>A0A2R6NY06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000690">
        <property type="protein sequence ID" value="PSR79625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NY06"/>
    <dbReference type="STRING" id="98765.A0A2R6NY06"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF132">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR79625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="439" mass="47854" checksum="5BF72456AF37A38C" modified="2018-06-20" version="1">MDIPSLTASFSDAYKTLVKEEPLTCAKSGMLFPAAPIPGAVIIDVGRTTIFLCKGVIDPASSQVFADGTLYVVRKLSQKPVQVICWVSCSATAGYTLFGPAGHNQDGGSLRVRLEAEAVRTGKSLPEITGELFCSVKGDVIRVPGMPPMYDYESHPQETVIKGHMVGPFHLAAIELVNGCDGILVATPDCFEPTEVLEAFQAWFAETSRKVYTVGPMLPPPGENAALNEKKQSASSGEIDEFMEQTLKTHGKQSLIYISFGSVYWSMQPEKIWTFLDVLVEKNIPFILSHGSPFAKIPDPIKEKVKASGLGLLSPWSPQQTILAHPVRLFHANTNDNLIHVMPEGDRICWPYRGDQPQHTVHLTDNLGAAYELLEVRTGELGSKPIYRTGKACTGTIEAVREEAQGILEKAFGEDGAKKRAKAVELQRAFEAVWAEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYF8</accession>
    <name>A0A2R6NYF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v6772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000658">
        <property type="protein sequence ID" value="PSR80300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYF8"/>
    <dbReference type="STRING" id="98765.A0A2R6NYF8"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR80300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="271" mass="28861" checksum="0EFA98B17322084A" modified="2018-06-20" version="1">METKLIAAEIATAAGVTTIITSSKDPKSIFKIIEYNNALKSGTSTPSQLPDGDAGPLISTHIINIAIPNLKTRPPHTLFKPSPTPLRDLKSWTSHTLNPSGSVIIDSGAHQVLSRRESGGRLLAAGVLGVRGAFASGQAVRILVRQRRAPADRAEVEHEAATAHELYLKAMATEPSTPTLSANESTNSSISTIDGMLGTSLSSPGSEDGTPSATLRTLPEEDHVLVGAEKDQSDEWDVEEVGRGLANYNSAQIARVKGLKRCRDVHHLFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYL7</accession>
    <name>A0A2R6NYL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v6715</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02000653">
        <property type="protein sequence ID" value="PSR80458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYL7"/>
    <dbReference type="STRING" id="98765.A0A2R6NYL7"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR80458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="986" mass="109107" checksum="0BFB8357071B9532" modified="2018-06-20" version="1">MDDGKGNEQEENISQNEYCLEVQPGGGKKEGGALNWATGETVAVKEIQLSNIPKSEIGQIMSEIDLLKNLNHPNIVKYKGFEKTREFLYIILEFCENGSLHTICKKFGKFPEALVAVYISQVLEGLVYLHDQGVIHRDIKGANILTNKDGCVKLADFGVASSTTAGAVRDNEVVGSPYWMAPEVIEQSGATTASDIWSVGCTAIELLEGKPPYHFLDPMPAMFRIVQDDCPPIPEGASPIVKDFLYHCFQKDCNLRISAKKLLRHPWMVSARKQMAGQQAAKGVEGPEKRPVSNYNYDQAVLKVQEWNEALKSPSKPAKHPQRRRPSENDGQGSPSLQPIDFGVPISTSFPSLHHPPTSTNGLKAIASTAKVPVAVSLHSHQIRETLPIPFILQQPEEQTDNWDDDFEEGISLTKLQALEKPPSEDEKLEIEDNGQTIRAGRSPVSGPVPLPIAKAPSPTIQPIAEDFSDTDFAEDDDNLQEKVANFKMKNSYRGLFHPDDIKTVGLTSSSPGPRTAPLPSLSRKPSRPSLNPLSSGAPSPRLHSRSSSFASPGGSFGRSEARRLHSQPEFRKYTEEDDEDYEDVFGKPSGASSQPMQTLQLNTRLSNKSWLGDDDDEEDPFAEIDEGFTEEDLETNLQRDKYARLCNTVNQLIDELTPSAPDFQLRDACDQLLNIMIETPEMQSQLVSAHGMLAIMEVLESRTSRDVTLRLLQIVNALVNTDMGFLESFCLIGGIPVMMGFTSKKYPAECRLEASNFIRLLCHSSVLTLQMFISCRGLKVLVDLLDEDYTEQTELVVHALNGICSVFELQSPTTKNDFCRMFIREGLLDPLSSALLNIMTSQGDSAAEMNGKIIQIILVFCQVSQSDIHVRNALGTRKVVRRLLRACELLEPEHLVHMLKAVKHLSMSATLLEVLQNANAIEILVKILDEQSTGPYSTVCIDSRSLPDCDGLTNPCRKSATTSSKPVIIFVDSISLDRKKLRKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ17</accession>
    <name>A0A2R6NZ17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000629">
        <property type="protein sequence ID" value="PSR81019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ17"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ17"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="295" mass="33836" checksum="68FD4A6A0BED8847" modified="2018-06-20" version="1">MFPENTLASFEAAMRDGAEGIESDVHVSADDVVIMFHDPSLNRTTNGKGLIRDQNWYGEEGMEHLHTVKEPKQSIPTFAETVTLLMKPENQHVKFNVDVKVQNNPDRLFSLMNTIVSAQPDWQTNLAPRLLIGLWHPSFIPYCRKHLPYCRRSYIGGDLEVARKYFWDNVDAFSIWFAALTTADGEKFRKECKAAGKQLMVWTVNDPQCMVEAVRWDVDAILTDVTKTWLDLRSALSVDYDKIASQHGRLFLWTSLWYYPPVQSFFRQKMKARLESFAGPFQEVDPSAPLVSARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZJ9</accession>
    <name>A0A2R6NZJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000622">
        <property type="protein sequence ID" value="PSR81321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZJ9"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="50896" checksum="9BCD12D7BDAD985F" modified="2018-06-20" version="1">MFGEDESESPRVPSPWDPFLPSPPGESTSFEAGKHLCNGIPKLVPEVEEASAHNLVFGNIEYKLKLTDISPARFARLVTQLKWRLLEGGGQAYYELGVADSGALIGLSRTDLEQSLETLETMAGEIGASVIVVKEIEVPSVMVTLADKVSGYIDPETGEWTEKMISKRSRAPLAYDSDSATVTSDVAELETDASVTDYTDTEEDSSAISTPMHPTTGSKFATALQYSRGPLSSNPDRPTSQSSPSILPIDDELALFSMDPEPPFHDALAVGANPNIMSDAHAFSLDIEISSVYKPRPIRRRMHTATGANPSGRHGRRGHKPKEKKQQPWRQSHPTETIDDMDTANIPNKQEAKALYRRIVRDRRREEKRKLDMNNTASGHDVTAAALILNDEGKLVTGLGALHVAVESVGAVATDTDAPSSVSPRLSTDHVTSGGTDIAKEPRLIVEALVVRKLSIDEAFLDFGGFSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZR3</accession>
    <name>A0A2R6NZR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000613">
        <property type="protein sequence ID" value="PSR81570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZR3"/>
    <dbReference type="OrthoDB" id="2554033at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="223" mass="23779" checksum="671EDBF59D6A1074" modified="2018-06-20" version="1">MSSNVDRDNDHSKPIPITIPRGRAHSVSESSSSDDSGSPSSPISPLQSPLTSTQPRVAPISPGSTPILNYFLSQSPKTQGVGTFPFRRGFAPAVLEEDSEPDLIAPTKHARRASTAAWPGADRFNPQPQPQAPPVQTDRAAGLLRRLSLGGAALRAPQTKTMSPTERASGIRTPPNSPVVERTQAMTPRKTRRATLAPGTARPKRAPSPMGERILTGHFDGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P074</accession>
    <name>A0A2R6P074_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000601">
        <property type="protein sequence ID" value="PSR81992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P074"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9658" checksum="ED898B86B845E513" modified="2018-06-20" version="1">MSVLVPTLFLAFAGLGVYLILRRRPKLTPGRIRSNDSILLEEEETRETPIIDIMREQSVVDSNQAVASWKAPSTVGSQALYFVPANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P083</accession>
    <name>A0A2R6P083_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v6134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000600">
        <property type="protein sequence ID" value="PSR82064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P083"/>
    <dbReference type="STRING" id="98765.A0A2R6P083"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="261"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="487"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="817"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="859"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="817"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="868"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="928"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR82064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="940" mass="105314" checksum="158F3D988AA28CAD" modified="2018-06-20" version="1">MATALGKRKSREEAAEDVKSHGSTIFVSNLPYSATSTDINTLFSDIGPVRSAFVVLDPTSGSSKGVGYVAFAIREDAQLAFDKVNEGGEGIILDNRKLRVQWAGLKPLKDDKEKPVKDGAEAKERQPIKHPKAPQPTGPRDPLAIRTIVVSGLPSPIDSNTLWKKMRKYDGAQKVEWPANVAGVEDKSTAHVLFSNPATAEEAVNKLHAHVYKSALLSVTLKKRLDGLSKPFKKPTAAKANDANDDSTMIAKTGPAPSRASRLIIRNLPWNITEQDLRAVFLPYGPIHSVHIPVTKQEHDEEGKERSMRRAKGYAFVWMLSKKDAEKALEGANGTNMRSGMADGLVKDKQKRKKLRREEAKLKLKKKEKTVKEGEEEEVDKVENEEDDEIEGEDEDESLAAERVIAVDWALSKDKWEEAKAKIQEHIEEVEDGTASEDEDEDSHIGLHEDDEDESSSEPSSDEEDDELEIDDENPGKPQLPPPETGTTLFVRNVPFEATEDELRTVFRAFGPLRYARITLDHDTGRSRGTGFACFWNKEDADKAIEQSDILRRETGGETSAPKKNPFKLPSLLTPDPSASVAQNLVLHGRTMDVIRAVTRDEAGKLKQEGERQREKADKRHLYLLREGIILPNTPAAEGLNQAEVEKRTQSFNARRALLRSNPSLFVSTTRLSIRQLPLFVTERMLKRLAIHAVRTFQREFKAGVRSGLTEDELADIPDDADDEEEQPGKGKGKGPGKDNKKKGRSTGVRQAKIVRQQDRVDPVTGKGRSRGYGFLEMEKHADALRVLRWANNNAEAGKLFDEWWKEELEDLIKAEKKKEKKEEGRLERMKTELAQGPPKKIKGSMIVEFSIENIQVVKRRAQAASQQEHKTGPPESRSKKDEQRIPLPQVKQEGTEKNSHERKKRRLSDPSVKQETPAVSKVGSLIGRKRKEKKAKRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0K9</accession>
    <name>A0A2R6P0K9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0K9"/>
    <dbReference type="STRING" id="98765.A0A2R6P0K9"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="392"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="758" mass="83144" checksum="CB6799D0922461CD" modified="2018-06-20" version="1">MSNEMPSWRSLASAAGRSIKGYVAQRDVRRPFPASKELRPDVSDPNARSSWGQWAGQKLRTLGQGEEGTNITVEKLLLFPGWACRKYTQPSGAATQDPVPFDVELFISGFASRSSGVGFGSRAGRAFLRLAKSYAALPKLAVAMAPEEVATPSINGIPSSKSEENLLASMHLPAKPDDMTEEAEMAALNEHLQQFDMDSASHKESSASSYRSGSPPEPSPISPSYPQSNLSAINLHQLHANLEARLFPFWASALGSRGVRVSVYASDPTAYETYKSPPLGDNYGEDENPIHQLPIVTQEILTAADGSFQMRLPLPWEKICVHPAALQIAFGDADREYNLFVVAELLPGPSRPATPTSAGQVAYAVRAPRIHRNVSPTATNSLVIPLTHSTVRLISDIDDTIKLSGVLSGARAAFHNVMAKDLSDSVIPGMGDWYTKMWRHGVRFHYVSNSPFELLPVINEFIQLSRLPPGSVKLKSYAGRSLFNGLLSAPAERKRTGMLDVLDSFADAQFFLVGDSGEQDMELYASLARDRPRQILGVFIRDANNRDLVKPLEDPTGEQVWRSPPSRNTGNDDSRSSLSTVGGGQSTLTPSTYTAHRLASKSVSDVTTPPPRLYATRQPKRTRSLASPPLTKEGNDYFTSQLILDAPISEEPATIPPPSYPPSSFSRRINNNNSGNQDNYFTSSARISKGRTSSTASSLKGAPQMTDAERKQYDLQTRVYRARLEMPEHIPLRVFREPSECVETEEILKRMNMGRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0L3</accession>
    <name>A0A2R6P0L3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000582">
        <property type="protein sequence ID" value="PSR82513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0L3"/>
    <dbReference type="STRING" id="98765.A0A2R6P0L3"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="42767" checksum="926D5DFEBB4A643C" modified="2018-06-20" version="1">MAPKRSAGGGSKATSKSPPSTRKILVTAGEGQTGRLLIDLLATDNTYHSKFESLTALVFSEEAKSLLQEYEDVQVIVYDPNNQEALVDAMSEIDTCMLIPPARKDKAKITRALLEAAKKAKTVVNLIFLSTVGCDFAESDKQPRIREFIQLETLAMQPKSDSSSGDTGHSTCIVRAGFYAENLLLYTKQAQGEGKLPIPIDPDHKFAPVALGDVIQVLAHALTSVGPHGLGDEVRGEILVVTGPMMTAGPELAQAASQALGVKMEFQSISEEEAKKILNSAQGEDVDEAEKEYLLEYYSLVREGKTNYVSNAPMMAFFGNRGQEPPDFFKTYSSEFKPKKRRTAKNGGGGGGESSAPKKPPSRSSARGKGGAQKKKEAAIEDDANFDMEDDEGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0N9</accession>
    <name>A0A2R6P0N9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0N9"/>
    <dbReference type="STRING" id="98765.A0A2R6P0N9"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR82610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="399" mass="42785" checksum="61448B65CCF5240D" modified="2018-06-20" version="1">MADGVTFIPLFIDNDYRSGDVTFEFRNPYTGQVAGIAASATSQDCKDAIESAGRAFVKWEHSPLEQRRDIFLKAADLLESPEFKDVIISAMRAETAMVEEMTVHNIEDAAMFMRKVAGMTNQLKGETFSSTVSGGHVVAQRRAKGVILSIAPWNAPVYLTVRAVGVAILCGNTVVLKCSEYSPWSQSVVARIFHGAGLPSGVLNFISMDSKDAPALTAGMIAHPLVRAINFTGSDRVGRIIAAEAAKYLKPCIFELGGKAAAVVLDDADIAQAARAVVSSGMYHSGQLCMSTERLIVQRAVSEQLIEEVTQLVKGLKAGDPRTDSTAQLSALFTENAAKGVISMMSEAVAEGAQVILGDLQRQGAIVQPHLLTGVTPGMRLWQRESFGPVFGQRISAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Q4</accession>
    <name>A0A2R6P1Q4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000556">
        <property type="protein sequence ID" value="PSR83599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Q4"/>
    <dbReference type="STRING" id="98765.A0A2R6P1Q4"/>
    <dbReference type="OrthoDB" id="2790700at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18785">
        <property type="entry name" value="SF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="346" mass="38720" checksum="AA219608EEC43756" modified="2018-06-20" version="1">MALISPPPTKRIRLYNSLNWADYNKDSRALFHKDSNLQILLATNSLMVGVDLRNVEDVYIAGIPKHPDEEAQKGGRARRDCTMVTDPRCIVYVAKSDFIAARAVLDEGKSGGKKTTVMDMDMARMLTANCTTLERNRLYKNPPLDTPCTCQKCAAQLLSLSPPSCISSCCMPENAPLPPIKLKWPHPVKQSQRLTKEMRTIGRTKLEELQWEIYFDEDVVRTGFLPPDTFLPEEVIKVVLDRFALINTMRQLEDTTATYIYLRPHQSKLWDLIQQLAITFSELGAAKKKRKKTAVFNLEEDNLLDKEIAPAGVKGIAATTSSTTSSEHTASTNGSVQQALLLKDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P222</accession>
    <name>A0A2R6P222_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000546">
        <property type="protein sequence ID" value="PSR83997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P222"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="8067" checksum="CC885A1421715015" modified="2018-06-20" version="1">MTATYAALHRHMSEEQPYVSVRGRKSKYNLPNMFDGGLSALMTESSGRDDTAATEESVETEPSLDDLTVELDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P312</accession>
    <name>A0A2R6P312_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000533">
        <property type="protein sequence ID" value="PSR84479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P312"/>
    <dbReference type="STRING" id="98765.A0A2R6P312"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="350" mass="40809" checksum="AEDFB27C3A9104F6" modified="2018-06-20" version="1" fragment="single">MVETPRLRALRAEAANLHAELDAYELQWRDKQEFLASQGYMLRPRYRPGWVPSWKTDTSRHPEKFEDYWELPFREHLIDATRISDGRLVYVKRVKTGDTESTIARMLSSSRFSEDPRNHCVPILDYFVDEDDTSVAYMVMPFLRLTNNPPFETVNDIIDYGNQIIQGLVFMHEQRVAHRDCSEKNIMMDADSLFPKGYHPVRSHHLPDASALAPQRWRAKGHIKYYYVDFGISVHLPTDPPKLVVGGYGRDQDVPELSFDVPYDPFKVDIFILGNMFKREIYDNYSNVDFLLPFINAMTQNDPKARPDALEAERIWGDICAKVSGLQRGWRLRGRKEVWVEKVVLDTYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5L0</accession>
    <name>A0A2R6P5L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v5341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5L0"/>
    <dbReference type="STRING" id="98765.A0A2R6P5L0"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="183"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR85865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="579" mass="62697" checksum="AECE0B5D3215C416" modified="2018-06-20" version="1">MISSIIQWFHYSHWPDCNWCSKGATHFANPNATVDGASEEQPNDDSASDEDAEKEDSAAPMARWLVNPRSSSGKRHVFGTHHRMKRVKRMTPLNEPGTVPVQGSSNAAAPVSDGLLTSIIPPSVDFPGTTTSNRVAGTDAPAQAPAKTQTGKPSCTPSPTKSLAPSASTYILLALDHTDHSFNPTAWTTCPYIVRDGKVNPDTNTLAGPDAVQGMAQSVLYNAIAYTLHKTSANSQNVAKFIDNFFLSSVTGMHPNVNFGQQVRGPGKDHQVGTFTGILDIRSLVKVVNALQLMRSTKSSDWTPAREQAMSNWMNTYVTWLQGSDIGKQTSTKANNHFTFYTNQVAAAKIFLRDTKGAADTLQHYFTTAFLDQVAQSGEQPFESVRTRPFHYRCFNLEAMITNAKLGDQIGLNLWTAKSKYGATIQTALDYTMSINPKGEDISDIFPLVASIAAAYGDPTGKYASFLQKNDGSYKSQPYWFYSQTAALVHSPAASKNKRDLSDDTVPAERATSVSPSTADIAGSGNTTAPALGNESSIPFTCPAVFANATAVEVEDGLYVTCKQLRPFYEIPMGVDSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBU0</accession>
    <name>A0A2R6PBU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000512">
        <property type="protein sequence ID" value="PSR88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBU0"/>
    <dbReference type="STRING" id="98765.A0A2R6PBU0"/>
    <dbReference type="OrthoDB" id="3243310at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="924"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="942"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113282" checksum="F4DF5CC59DC6896B" modified="2018-06-20" version="1">MQNSIVPREASPSPSFRERQRAIKAHSMPIVPSVSQILSGTSTQQNLPQPSPTGSNGSLPARRSPPVTSRISPAAPKLSSTNHMSPTSRSDRSPERMGSPPPLLHSQSTPVVTQMVSSTQPTGPGMLAAQPRPTMPRGQPPQFLTQYQTMDDRWHVTDELLAEIERADQQQGQLQGTSGVAYAGGAASNSSLHLQHTLNIVKDPAVERVRASDRSSPKELENGMKRQVREKERESPKTRERSQTISSMPSQAHESQSHAQRTPEYRGSPPFHTPLSSPSERTAAYGQYIADSYQVQPQSTSPPVVRKPVPMMAADTSSTRSTPPGNTKAPSQTPPNQPVNTRAPDRALPLQEEPEEDVGHEFPEHDTEYDNRRHGSPTPSSNIYPEGHSARYDDRSGSGLPHSDEDDDDDDDDDDDETLNEEVQEHLQTKTDDEDSGFTPRSPSTTLPERSRDGSYPPISSVQYMASGSSYAQVAVENQKTIRAKHRAGSTDQLGMRTLDPALFQHTMDASRVNGQVAPVNGQRSSQPMRQPEFAATVQHQVPVHAANARQPTSSDRYETQQHVAYSSRSLPPQMSPHFEDLQGLFDAPTSSYLQAFLQSPNARPNAPIPPTPQTHTAAPSPSPLSAMPSDIEPRQIGSPYPYPFTHIRRTALSAAQNAASSTYDPNNPDFIREQLALQMQIYALNNGLAPPSDTTFSPSSTPFPGNGYNPWGFLQQTTRPGDTTMSLRSSPSHEPIPMPMPPMRGRGLRRKDNAANLRAPVARRRVKPPPRVESTQPRETSPEPSSGEETAGEDSFIEQFAPAQNGGAWENEDVEDGEETAVDESQWVDEEEEEEEDLLQLEYHPTFVSSVEKRRRRWETRWDTLTQAVQALDRETDTTVIVLAAPSHTNKLHALTSRSIRRDMAMLNAPALTKIRSSFSRIASQRRASRTKRQSFADRLSSAGSGSSADGSPNSNVSREDDLRRALEGALGSLSALGNIYDQREARWRDEMRRLSDDRERVELLLRQALGPVLTNGHHVERPLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PC36</accession>
    <name>A0A2R6PC36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000502">
        <property type="protein sequence ID" value="PSR88864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PC36"/>
    <dbReference type="STRING" id="98765.A0A2R6PC36"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000018">
        <property type="entry name" value="Multiprotein bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR88864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="125" mass="13567" checksum="4F5120057045BE06" modified="2018-06-20" version="1">MSNLDWDSKTVIGSKAKVPKVTRNASDLNGTDHQRIAKLDRENEVAPPSKVAPSVGKAIQTARMEKELSQKDLAQKVNEKPSVIQDYESGRAIPNPQILSKLERALGVKLRGSSIGEKLGGPKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG17</accession>
    <name>A0A2R6PG17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000494">
        <property type="protein sequence ID" value="PSR90567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG17"/>
    <dbReference type="STRING" id="98765.A0A2R6PG17"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="25"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR90567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="678" mass="74779" checksum="BE109E2D257FDA19" modified="2018-06-20" version="1">MSRIPPGLLYLTIYNPTLQPIQPYASDDEDAEEQAHILFYTGRERAVSRDKILRQVGLAKALVNFSHMFNDQNMCENVHSQTRRMVMVSPEPDFWIHACVEVSKTQRPLPTKGKAKAKGKDKDKDKDKLQDTSMRAGAVYDYHDGSVHDIALRSYILQGYEEFKLTHGSFLSILSLLGQQALELQIERFFTVWAWKWDVEDNLDFGDHLGVPMHPTHRAGSSLLDRFAQQHLSPNTLPFVLIPPHVIPSTRLLHSGYPAVLVRYIISKIPPPSANTQDSALSADKEDKDLATDKPPDIATLAGLEGKISDYTKSVANPFSNMDMRNLKWMWTGLTFGKGLSTKSMAPPTPSISTTLKELDAAGQPDGQEESGVRADYLGKGAEVEFDAESLQEAISENVSIHDTQNSVVNSPLPPSVHLQGEPDDQEIGSNLESSLSLQVEGVAVEVGEDGAVTPEQAVISPQNGQSEPSVETTTENDFGRTASPPMRERVPEFVSTSVFLANPETPTETTRKKVFHTTIDRFTFAFIAGDDHGINLTSLGENVNDLVNELRACLAIADNKGDTEISLTPVTKILEPQDQYIISTGPYTSSLHSGFSSNSEHLFDCQAILHNDLNALEVFSRGQNPQHWHLSKRGLGIDESGDSVDGEVYMEVARKESTLTDVDNELASVVRQFTQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PK37</accession>
    <name>A0A2R6PK37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000470">
        <property type="protein sequence ID" value="PSR92437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PK37"/>
    <dbReference type="STRING" id="98765.A0A2R6PK37"/>
    <dbReference type="OrthoDB" id="3267098at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR92437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="141" mass="16510" checksum="A9B7905D6224D967" modified="2018-06-20" version="1">MNKQNFTRQITRQHMQEELIQRVKKRVEKASDNKDKTVQPNDLSVSSRATAIQASLSFAESNPLPYTPPEKHDHLSQSNRFHQNMNDWLNSNNGDPALKKYDGNKHEYTDGERQALILVNNRIYQYKAVCINYTTYNLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMX6</accession>
    <name>A0A2R6PMX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v4663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMX6"/>
    <dbReference type="OrthoDB" id="2755611at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015305110" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR93768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24464" checksum="29609D3FD1922468" modified="2018-06-20" version="1">MFLLFAVLYLLPQSILARTEDAGSSSLLSPSLTNEREPEPRLTATSEEEESRATSTATSGSITIIAPTRRPLSQTHTHSSNDSRPSHSLTVHPGAPFTHPIPHPPSPTSPDHPPDNENPPQTHRSGQPIVAIVFEALAGVVGLFILYGLSRCLWSWKHTPERDRVASLLSRHYLEREMEEREREQMEQRMLRAVPRPLPPPPPPYQHAPSYEAAVEECAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNF4</accession>
    <name>A0A2R6PNF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNF4"/>
    <dbReference type="STRING" id="98765.A0A2R6PNF4"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="83"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="469"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR94139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="727" mass="79400" checksum="5B9FDC0F4285A516" modified="2018-06-20" version="1">MPIPAVLPVPYPPNANRNKQSVEVPGTKKPGQTAAFPFVSLSSPDAFVNVVELFDSGRQRVDGKHPMLGWRPVVSQNPLKYADHYEWLSWDTVDMRRRQVGSALHKLFADGVVGGGPLRTVGIYSGNCPAWQVVDLATHAYEIVSVTLYDTLGKDTVGNINHTEMSVIFVANHHVASVLKLSSKIPTLKMIIAMDQLPTESKTILTAWGEQVGIKVTDIVELEEIGKANLREPIYPSSDAVITICYTSGTTGNPKGVVMTHGNLANAVHAQMYGIDITELPVSIAFLPLAHCYGRMIELSIIGRGGSIGYWSGDPLRLLEDMQILKPNMMPAVPRILNRIYQAGMAAAELPGVKGALFRHALSVKLDRLHNTGVSTHAIWDRIVFKKVQAVLGGNVQLVSTGSAPMSPAAIDFLKVALASEVVEGKAIRAEGVTYYTTDFMHGPLSQGAIFLVWVFGLHTYTDFSIIRYGSTENIGTATRVWFNDVASAGTVGAPQVNTELKLVDVPAMGYTSEDKPHPRGEICIRGDHCFAQYYKDEANTKATIDEDGWQHSGDVGLIDESGRLKIIDRVKNIMKLSQGEYVALERVESLYSACPVVAQLYVHGDSLQSYLLGLVIPDPVQLAAIASRVWGTHVSDKDTVALDRAIQDPKVYGAILDALNKQARLVGLQGFETIKRIHLSNELLTVENGCMTPTLKLKRKDVYSKFKKELDALYALPEPSSKAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNL9</accession>
    <name>A0A2R6PNL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000446">
        <property type="protein sequence ID" value="PSR94656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNL9"/>
    <dbReference type="OrthoDB" id="3023191at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015337050" evidence="2">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR94656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="246" mass="26729" checksum="7A1165F736327E53" modified="2018-06-20" version="1" fragment="single">MHILHYLVAFAFITRVCGGAVSFEPREEAHSLDVAARDSSSSTAETIELPSNSLALRSSDSSLATVSWTFGGNKVLNFGVFIVNSFVVGAVCAASGAISCGIAAAYAVFTSFFAKWAFSSRSTDFDVSDLGADSEMYLTLPPTPEKTHVQRLSTELEPGTWHTIGHMRVGIFNHSLHYYNHGSNTHTLRAWQRNFVLNGTEGSDKRAESDNDGTVVDYSWQSTNEQSYNDFGSSSDSTSYFAANAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PWG5</accession>
    <name>A0A2R6PWG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v4279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000432">
        <property type="protein sequence ID" value="PSR97713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PWG5"/>
    <dbReference type="OrthoDB" id="3064017at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="108"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR97713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="359" mass="41388" checksum="E61C30A6E368B9CE" modified="2018-06-20" version="1">MPYMPEAETLWKNQEAAKRRRETLARNWNMNIPPTPSNLAALSPSMPTMTTAHHGIPVPNNQYGTTEKRTENERNEQEDANPKKKRKKNWITRSDQLGTNQRKMLTERAYPFLRVRIACVNAFPGEETEQLFICNAFWDAIEKLQAMGLDLSDEDLDPSGDEVKLIHDRIAQTQGDVRDIFVQHPDRWHKFTPCSNSNKAAKNTNRELYKRLITNNAYIYEDPEDLQRGMYRHASISFAIKKMWFDSKNDLRITMHGYFDKDGALPHKIIALAATAETGVAISGKNGIKFTENKYASCYRAHLQNLTQWEAYSNMRNKSCLLLRRQLLSDALEHAGVTIEMMDESIEGFTMAHFAREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7J0</accession>
    <name>A0A2R6Q7J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000382">
        <property type="protein sequence ID" value="PSS03718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7J0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="236" mass="26028" checksum="7163B44712F7D2B6" modified="2018-06-20" version="1">MVLKSTHCPSWDLALKLTEENIDEWASLIDQSNWFEDSIIKRNFKAFSLSGLGEESRYAPFAAVANRVLKLARGSLPGVYHSYPIDDIQFARNDPNYMLRIAEHGKLGAFRKPDLLILRGASADGIGATVKGRVACVDVLGFAEFKRGRTALKALLKDVTSKHDLPPMVEFREPAPEDPVAGNFTKKAASVDEALTIKREAAVQAGGYALETAACTYGTRLFVHGIIIDDDKLEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7J7</accession>
    <name>A0A2R6Q7J7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000384">
        <property type="protein sequence ID" value="PSS03523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7J7"/>
    <dbReference type="OrthoDB" id="2804425at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS03523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="537" mass="58025" checksum="8B649EE7A5B34681" modified="2018-06-20" version="1">MSEVSAAAAKRITRSTLSHQDPNSVVKTTGAVPTHNSDLKESGNEGQKHGKGKGVAGRPEHEGIVTSQSSAGPLPLTDVPTTPMPNIPALCHLPSPITPSNAMGVHCTPASSVMLSLPPTLSPVRLASGLDCAAEKSSFGNLLPLPSTPPLSRAPLPSTPSSSSRTSLPSTPSSSSAASMPRTPVNGSMSYWETKMRGIRDNLLAEGGYLGDPKLNVRQAFQWVQFENGRILCTREVAAAYDQAYAIFKDDVVAVDPPPAPDAVNLSGVYRIDEALFFMTADGNWNPKQDFGGFEESKATCLLAAAHDSVFAKDYPLMNKNINTLVKMGVSGDNRVLRGIFNVTDDGRKLLKLRHVLFEANEIKEANEGEDDVEGEVALSEDDQVDGDGTDDYALDDLLQVTANGGRHLTQKEEREFLIRGWPVKKRVAKEELAALFNSHQVTPIIAFDISGDRILPSTYEAQLKGADVQVHFNMLHWAFGYTKKPSTLSDTIVADLANMRIIVPGKVAPSHSKSSPRKKRVWQKDVFTPQKKVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7P6</accession>
    <name>A0A2R6Q7P6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000382">
        <property type="protein sequence ID" value="PSS03732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7P6"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="70" mass="8002" checksum="32C4D40B5CD26884" modified="2018-06-20" version="1">MSQGTAQPAYPDAWINYKKYLSETSVLIPLPPALYRPLPGWIKRTVLLDWGMYRFDEATDGKRALKESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBA2</accession>
    <name>A0A2R6QBA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBA2"/>
    <dbReference type="STRING" id="98765.A0A2R6QBA2"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="167"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="347" mass="39443" checksum="E5BC4AF3207B31C8" modified="2018-06-20" version="1">MPASRPVAVAVGYYRFTDIFFEWHQALPNPQTVGPLKATIAYDALVHPDHPLRKAGVDGIELYIGTFPNGEARLLFSSAQIEYIRYWIHAVGLAEELIPLPGGDWLIQKNDMLSCSPAVYNDPAVLKKAIKTIDKNNKRLKGSEPLLTSRRLGFERVRTYWASKAGTWIAIDIEAWDRDHTVLTEFGWSLIRWEKGEEISEAGHLTVEEHRSYYNTFVAHNREHYSFGESEEVDKKTFKKRIRDLIGENRSKGPLFLVFHDANQDVKYLRSSAIEAPITNLTYILPDTTPNDGLYVVDTADMFAALEGESGGNKRGLERICRHLQIPVDYLHNAGNDAYVRLVSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEE7</accession>
    <name>A0A2R6QEE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000363">
        <property type="protein sequence ID" value="PSS06515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEE7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="11205" checksum="1469D4EC6E1C0BBE" modified="2018-06-20" version="1">MAQNIMLEEKNTAVSYTSPLSKSVWWVTLNINVRTIQLFLHFVGSTTAATAERYEQRSADMSYPMTEKKKCATTYASCWSICHWSRWKIDLLFGAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM84</accession>
    <name>A0A2R6QM84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM84"/>
    <dbReference type="STRING" id="98765.A0A2R6QM84"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="3">
        <location>
            <begin position="344"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="545" mass="58650" checksum="641787E6F3923BC2" modified="2018-06-20" version="1">MSLIIERAGEVQVRVGGNTQDYATLVGSTVDGKAIEKQSIDPNNPTATPTIIFTEELLYMLSNISSLANVKWFLGVPFNDTQNIHLEIVESGERILGDTLLGFQVGNEPDLYAQHQHRPSTYAPSDYTTEFGQWRDAWQNDANIPVKNNMIGPSLSLANWALEDVWNTGFLTDYQTQLSALSVEKYPADNCAALYAGLGTPVVPQDVYAEYLTHYSGVNIVKPMLNSTMIAQQQGKPFIMFETNSASCGGFAGVSNSFGIALWALDYGLQMVFSNFTHALVHVGGQNVYYNPFTPPPTNQSTFHQWSVGPIFYPLMIMPEILGKSNTSQVVDLWPNSGSDQTPGYAIYENNQLARVALFNYMTDPTGAMAYTANISMGGGETGQQQTVPASVKVKYLLADSVSQLWNITWANQTLGGQFEADGRLIGEEQIETVECDTTANVCPIRVPAPGFALVMMTDDSASGSEPTGTMTFATTALTKTANTATIDQSVLETSNGHSGKDRIIGGSTSKGSSGAGKAAGITPSVAVLVAMLAGAGMFMKVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R786</accession>
    <name>A0A2R6R786_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000272">
        <property type="protein sequence ID" value="PSS22634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R786"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS22634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="82" mass="8285" checksum="CB871C2688C4222A" modified="2018-06-20" version="1">MARSFCKVPNTLWQRDNFGSDYSNACNASLGTAFNASSSFALAIPSGWNGPFGQGLSIGGTVVAVGVTVILGAGAIAVVNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7C5</accession>
    <name>A0A2R6R7C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7C5"/>
    <dbReference type="STRING" id="98765.A0A2R6R7C5"/>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS22650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="149" mass="17062" checksum="2A4C73EB321FEC61" modified="2018-06-20" version="1">MSRQPYTPQSPPGYVSPQSRNYSSRSAYPSFLSPQETAFLQLKAAGQGLLDALRWDVVVRLVASDAEVRSSVFKSLLMNSVSLTSIYFFDLLLLPLTREKEYWLHRNVGWFYQVMWLLPVVGVSLYLNVSDCATFMLTPRRYTFLAYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R7F9</accession>
    <name>A0A2R6R7F9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v3043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000271">
        <property type="protein sequence ID" value="PSS22677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R7F9"/>
    <dbReference type="STRING" id="98765.A0A2R6R7F9"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS22677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="256" mass="28292" checksum="ECBF0660481D7D83" modified="2018-06-20" version="1">MSPARIPVLLGTGQVGTDGNARFTDPALIQQWVDIMAKHGQVGIDTSRLYGKGTSEKLLAQLNIEGMRLDTKIFPLSPGEHEPTKLKETFKLSLEALGPNKIRVFYLHAPDRSVPFEDTLEAVNELYKQGFFGGYLTGKLLDPSAKPEPGSHFDPKWHLSSMYIGRYKATAAAVTDLNITAEKHGLKLSEVAYRWMQHHSSLGPKDHGIILGVSNVQQLEDAITDCEKGPLPEEVAAACEETWQRVKGTANPQYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHR3</accession>
    <name>A0A2R6RHR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHR3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="240" mass="26701" checksum="BEDB674F7687BE25" modified="2018-06-20" version="1">MHHAVTTEPTPTLLDHGPKTNALQTTGSRRLHMTAGVLKKTKRVVGALDRLDPPVPFRIEDAGSERISVKQALSILIDVKELHKYCLELKMAIGGEDAQADPDDLVAAMAAAGEDHDEWQLCQHLYTLILRRYRWTITNLRDRAALQDRLRVRDVPVTIDPLKARADEMQTPSEMVRTTMQIDAGMTLPLVAVPTDAVDTEFEELEQENVLRIVYKLVGGPGCDPQSETLPIQLGLEALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHW0</accession>
    <name>A0A2R6RHW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHW0"/>
    <dbReference type="OrthoDB" id="2549021at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS29614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="114" mass="11965" checksum="E8EC49B3F86EFFFE" modified="2018-06-20" version="1">MAFTAGASSTKSIPGSPFSGFGFSGMSRSTSKVIMRPQGVVLSTMGSIHGDAMASSSGLELDNLEALGIAREGDVESGYQEVIGSAVSGIRVDVEKTTMTHSDRAPFERHFVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RHY7</accession>
    <name>A0A2R6RHY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RHY7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7008" checksum="8FC6B3F205C121BC" modified="2018-06-20" version="1">MSALSTPVQDDLQQQPQDPQQLQGQPSLPTDLQSPQQNIQNGDTPPVSEGTRKRTSSVLLALRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLK0</accession>
    <name>A0A2R6RLK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000234">
        <property type="protein sequence ID" value="PSS30898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLK0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS30898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10125" checksum="1AF70205793898CC" modified="2018-06-20" version="1">MPNQWLDWWCAIQPSPRRTEPVSFEINLDHPKNLAPQCWAPISKSGPQGISNMVYALGLSYPSAKRQAMILGPCPSVSGMGFHTIAATTDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLV2</accession>
    <name>A0A2R6RLV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000231">
        <property type="protein sequence ID" value="PSS30955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLV2"/>
    <dbReference type="STRING" id="98765.A0A2R6RLV2"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS30955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49275" checksum="B0D189435D8AF050" modified="2018-06-20" version="1">MCRISKGWLAYLTVKDKKVHLYIKDLHERYGDIVRIGPNELSIIPKDTTTTVIGPKGLPRGPYYNSREHEGGVSLDGIRDPALHAARRKPWARGMNSTAMKYYEDVIRDETTTLLRVLRERKSENTDISEWMSFLRDAAWISHIPWIIPLLKYLPSASKSWEDMKVVGATLVKRRIQDGSTHPDLFHYLMDEDGNEPVKPSLEVCAGDGMLAIIAGSDTAATTLSHVWYCLLSHPKCFNRLRSEIDEVFPYGEDPMGNLAKLAILPYLNACMLSAIHNEALRLYPPVLGALQRRIEPETGGIVIGDHFIPAETQVSLYAYAIHRDPRHFWPIPDQFWPDRWLSQEKYVLPSGDVIPLDQMVNNREVFVPFSAGPMVCAGKNVAMAEMRAVISSIVQQFDMKVEDQCSLSKWEGDIHEVFVTSRGSLPVFLEPRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLZ5</accession>
    <name>A0A2R6RLZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000222">
        <property type="protein sequence ID" value="PSS31032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLZ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="109" mass="12092" checksum="C9BDC462EE15B581" modified="2018-06-20" version="1">MIIPPSLPPILISRFLFNLRQVRELENPTQGAWNSDFTITGFRVPTLASFVGNMCEELDFTLDHVPCEPQGNISVGVPDPAVGHPAEEFGIGYSDDSEIRVYRSPISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM01</accession>
    <name>A0A2R6RM01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM01"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="496" mass="55755" checksum="4218F5B33FECCF70" modified="2018-06-20" version="1">MPPDLPLDIVPLILQHLCKKPMSKEWHPFQQAEDPFSSGDLPDEGQLSNKCDVSWKYDLFSFSLCSHAMRRAALPFIFESICYRFKSIWHKYPLTLNIAIEQDPSSTSVPSTPTRPKGLELPALQDLYEFMAITPHIAGVVKNLQLYYTAKPCYRHSEDTPGQEREKNLHHIDIRDLGKFLDLFGCLRSLELLGIPIDVPQSYHVLEIGGRAIDRLSFDSSHQCIFPPTISIQPYLAPLLLFDKIKKLVLDYPSQIHRPTSDGPLAPVYFPFPGESLVVMCSPGLVGPVLERLADTDASRTETHLRFLKVCELTHSDLRPLNKLLSRFGANLVELELDWTWDYGSQVLAPDDNFKLLSHCKNLRVVSIVMFDLSVPHDLDGAPQERYKIVAHGLVCLLSSCGATSIDLMLEIPWELLAALQDVLLDLNKRGVLRSVYVLPVEAREAWSQQIRQSKLDKFTDILDTSGIFAPLRESAQRIVAKALGVGLASGATRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPG9</accession>
    <name>A0A2R6RPG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000214">
        <property type="protein sequence ID" value="PSS31924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPG9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS31924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="228" mass="25252" checksum="F2BC1A5DB1ED31C5" modified="2018-06-20" version="1">MDPLDVFPTARPSNVFNVSLDRLDYPGPQPSHGSPHQPYNAVHPGIAVVFIPPEVVRSGENLTLHLRPPRSQRHSCQPGVLCCPAKQALVRSPNFFHAPPFRSQRMRAQRGLADRLPCQSSAGPPNVVLDRKFKRARSSSTESRTSVPSSQPWEEELEVRVVAESVVEDKYESDSGSETEPEDCPGCVRCSREYMHLHKAVYSHAAALAAVRTAFFGYAATALRRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPN6</accession>
    <name>A0A2R6RPN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v2229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02000207">
        <property type="protein sequence ID" value="PSS31987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPN6"/>
    <dbReference type="STRING" id="98765.A0A2R6RPN6"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="367"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSS31987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="531" mass="60004" checksum="54B1AF814E57DFF1" modified="2018-06-20" version="1">MKEKLKIVQGSDFYTIYVRPTSEPLAAMEGAQVSHDDKRLSDEIRFVKFSSVSWTHDSKGFFYQRYPDRQSHGSASDDLAGTETDSDKDAMLYYHKVGTSQSEDILVYKDHTEPEWFFGAEVSETDGKYLIMSVSKDTSRKNLLWIANLENDKIGENMQWDKIIDEFDASYSYIANDGPKFYFLTNKDAPQYKLVSVDISAPSEQRVWKEVIPEDKDAHLEDVLPVNHDKLAIVYKRNVKDEIYIYSTEGERLTRVAPDFVGAVNLNGRRSQAWFFATLTGFTNPGIVAQYDFSKKQEEQWSIYRTTILKGLIASDFEAQQVWYESKDGTKIPMFIVRHKDTKLDGTAPAIQYGYGGFTISINPFFSASMLTFLQRYGAVLAVPNIRGGGEFGEEWHLAGTRERKVNCFDDFIAATQYLIDNKYAAPGKVAINGGSNGGLLVAACVNRAPEGLIGAAVAEVGVLDLLKFADFTIGRAWTSDYGDPHDPQDFDFIYPISPLHNVPTDKVLPPTILLTADREYQLFVVRYQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ02</accession>
    <name>A0A2R6RQ02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000199">
        <property type="protein sequence ID" value="PSS32075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ02"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ02"/>
    <dbReference type="OrthoDB" id="3260094at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS32075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="200" mass="22575" checksum="A94E2A74D3AAAD11" modified="2018-06-20" version="1">MLSGGMKKRFTFGFIIEGTEMKLWYCDRSQTVAFQPFNFITDHEFVVRFFLSLAVVDGQDYGDPVVLKDCWASSDRQREGKIHEKLRNVNLTDAFRGALDSSFLTVERHGDVSVSSKSDRMPLVLTLEEMTRPGYIAAVHCDVSTGHILIDSHGKARLSDLEYAKDMSDKSDPESRIGTTNFVAAEVQSQAYEFRPRGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ67</accession>
    <name>A0A2R6RQ67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="MLYV02000195">
        <property type="protein sequence ID" value="PSS32135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ67"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ67"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS32135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="238" mass="26364" checksum="C7EAF6FE1CCD2725" modified="2018-06-20" version="1">MAAKGKTAPTVKVQQGSPLTKWFTRAVVLLVFLATCSWLDTIKDRWYVFNPKSLHELAQAAIAAAPSPDDTTFMVQYIAANLTATYPSSQIALNPNTSEWVISNAGGAMGAMYIIHASITEYLIIFGTPLGTEGHTGLHTADDYFNILMGEQWAFAPPNLEMERYPAGSVHHLPRGYMKQYKMHEGCFALEYARGWIPLMLPFGLADVLSSTLDYVSFYHTARITGREIIKNLLIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RQ71</accession>
    <name>A0A2R6RQ71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v2054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000190">
        <property type="protein sequence ID" value="PSS32181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RQ71"/>
    <dbReference type="STRING" id="98765.A0A2R6RQ71"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS32181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="219" mass="23679" checksum="1387B65BB8FA2D18" modified="2018-06-20" version="1">MGYLYSAESLNSLRPENSRAVLAAACLLGGMDDLCGYAYELARQSISIENIGDWLEFVEAIPSPSDGTSTPIEQHQVPQSRTAVFGSYAQRLKDDVFHFLVVRLPSILNVSGVSTPVTPQTEGAPSDAGRDTLLQIYARVPFDLFKAAVESPTFQIGSDQARFKFAKDAITIRKRGTARGQGAEETVVLAFGGGGANMGSSAVHVTRKLRKRPLWKVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVK2</accession>
    <name>A0A2R6RVK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000161">
        <property type="protein sequence ID" value="PSS34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVK2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="105" mass="11874" checksum="EFE6E819E25B2121" modified="2018-06-20" version="1">MPPTDHRSNSPASSSNTEMSPATLKMLMSLFKEKKGNVTKRKQAQKESEKNEDETLEKTWTNYGRILGRISNPFDKSLKVVEHGLILEAYNPNDPEAVPRSNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVX5</accession>
    <name>A0A2R6RVX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v1791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVX5"/>
    <dbReference type="STRING" id="98765.A0A2R6RVX5"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="27522" checksum="949CB87A75CDE748" modified="2018-06-20" version="1">MSNGSEGGHHPQHETPSQARIPSRTDRGALTRKTSKSNTGHRPKPPVVVPIDWEIPRKLLHSSIGFLTLYLYISHGSPRPVVVALGSALAIIAPADILRLNSPGFERAYEKCLGFLMRESEKKTANGVVWYIIGVIWVLSLYPIDIAVVSILILSWVDTAASTFGRLWGRLTPPLPPRVPLLGLPFAPRKSMAGFIAGTVTGALVAAGFWGWIGPVGNIDPTWTLGGGVAGTGVLGGWVGLSVVSLVTGLVSGVSEALGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZK3</accession>
    <name>A0A2R6RZK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000126">
        <property type="protein sequence ID" value="PSS35461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZK3"/>
    <dbReference type="STRING" id="98765.A0A2R6RZK3"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="370"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS35461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="437" mass="48973" checksum="71C8FAA67D506BC9" modified="2018-06-20" version="1">MDLVDRLLSGALDTAIVTHDKSQYSGTGGVSACGLAALNCARIVLGRERDGIRGASLLREIIKQQTSEVRLRAASLRHGCSSCAVITRPPEIICCFYIALPESEMFIVFDSHPRPELHPEGAAFIFHTTSEGMAQYLDRLLPYDRSLLADKNVQWEAQLLGNFSGHVFVAKNQPASIEHWTNADMQASLQILHLRAEWLELKSQNSNLTRDNSHLQEEVERYKRELAAERRRTKAPSPVQKAASPSRNEGILATIVHHGSNALSAAWSVGAVPQEEPGWNQVSRRSRALPTPDRTSQHASTSRNDPSRLDPTKQSDRGRSATKRTDSIDVDTSRDLELALQQQLMFDEENFHLLMERDTLVSQAPEVFECGVCFERHSEESVAKVDKCGHRYCRDCVRRYVSSQLGERRFPIFCPLCVADKKSQEPAGQSRSWRTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3K8</accession>
    <name>A0A2R6S3K8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000095">
        <property type="protein sequence ID" value="PSS36861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3K8"/>
    <dbReference type="STRING" id="98765.A0A2R6S3K8"/>
    <dbReference type="OrthoDB" id="3147730at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS36861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="155" mass="17699" checksum="1060C300F520E759" modified="2018-06-20" version="1">MNPLTTLDVLVIPADDRPPHIASLMTSPMTVILPNPVEPYRCGRMPHPEVFMDYIAEGLGPRSWRYHVVEALEGMTKNFATPYIIFCPRVSRDGMPFPVNKYIRDLQGEFYEESMAWRGNLVVAKYRNPEYSAMTEASMADFPILRNYLSTHGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S441</accession>
    <name>A0A2R6S441_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S441"/>
    <dbReference type="STRING" id="98765.A0A2R6S441"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF64">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="55177" checksum="9EC6165FB90EB385" modified="2018-06-20" version="1">MPSPQVLTTALDFPIATRWLSRSVTGFPGTRRAARNVEESEGGQQDSELKLPNIVSLCIVLCTSALLQVSFFIIVSSSNEYAQHLGGTSTFSGLVIGIPTVFSGLALIPLMKLDQGVYNRPLHFACGSAVLGHVLYALAYKANFLYMVLVGRIVSGFAFTFWMYAKRYCSDARIVGIRRRTTLAGWLVLGQGIGFSLGPFVGGVLYKIGFSNPVFNGFTSPAWIMAGIWTAWWIFTAMFFKDVPIVPPPSTEFELRPIRVPKNQGIDATDSVSQKEAAETNDPERQRTEVFTVESETVVEVTQAENSRMSAPQWGVTATMCWFAMTCFFILGAWESNIPVFTGSSSPLSPFHFSPFAAGNLIALGGACTFPFLFLNVLLAKRYQDRNTLALGTSLGTAGLLIALAILSTETVNYGSLFICWFLVALGFNLASTVTLSLLSKQLPAHWNTRISLAIQYSNYIGRATGAVWGGAGLKVGMLSYVGTQIAIVGVGVVMFSVLWRELKAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S451</accession>
    <name>A0A2R6S451_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v1081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000084">
        <property type="protein sequence ID" value="PSS37042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S451"/>
    <dbReference type="STRING" id="98765.A0A2R6S451"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015346623" evidence="3">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="229" mass="24707" checksum="7FABEE5994EC5931" modified="2018-06-20" version="1">MHSGWLVISAFLAVWEPTTYTGPSDVDQLGTMYLAYIPSDQVDTLANLIRAKQSVFYTDLPSPYKDLAEHVVPSFPVDATSQSSGSDGGSSNPDSGSSADTVGSSSSSKTREDAIIGVVSSLGAITLIVLAFLVVRAIKQRRALAHHRLSDSQQDDMYVGARPDNQDFDRDSVGGARRRSFYYAEDSLRGAAGPPQGFVQSSEAGMRERRPVNAAMIGTPILRDNTMNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4P1</accession>
    <name>A0A2R6S4P1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000070">
        <property type="protein sequence ID" value="PSS37236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4P1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4P1"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="32"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="714" mass="79760" checksum="287AC12BE04D0ADD" modified="2018-06-20" version="1">MSSYDRAHSEVSILVWMMEFSEIPYQEVHPIWEEALDAASKHDKAIIDGWKDELANLLIFVRATTFRVKAQFDNAEKAGLFSGVVTAFTIYSLPMLQEDPADASAKLLAQISLQLSSLTVANGFINSSSSSLNFPNLGATFAPTDAAVAINTLWIVSLVLSLMSAFFAILVQQWLRNIPATPSHLTAWQSIRMQHLRHQSLNRWYVPEIMALLPSLLQVAVILFLFGFHFLIPPAFTSTFIGVLSVFMILFLMSTILPFLDTTCPYKSPFVLAMLVSYQCLKILLFPIIIIIVICAIVADMTAPSTMTTTKTLKMLGLYQSLNVHEFWTNRERPILAADAADAQALCSALYKLPRSSLSKMTKRLSELSNKMRAQVALRWIALDLGNCNYEEDFTGPNRPRPEVLARLDRQIADRFKDILLAALPQSWAHDTQSSSSICILTILCEMRKWADKEFQSRVTRLLLAIRDAQSPALAITQPSFAAIMPTKLICSYCMDDPFVFGPEESFNTLRWANDIVSSVAKNVDEGQSIKIGQVSLVLNSSATALFLASAHSAILGDASTRSQIRNLLRMLAGLMISKRNSIAKLCSKARFGTPRNWYSEHVQRPLVAICRFLKDTAANKAIPARERRLGLSSKLWWSLQELCKDQGILQELDADVYLQDLEDVPLSSGDGDMMLGAYLDFWCLVDFEPCEGFSVPVVQYPDLSQVQHAAERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4U5</accession>
    <name>A0A2R6S4U5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000070">
        <property type="protein sequence ID" value="PSS37239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4U5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="570" mass="61269" checksum="D230E3408240E53F" modified="2018-06-20" version="1">MPAIAPSQDVEEATIEQVICHLGNRSTSYQPLQGVDSAAFPFLTHSLFPVATSAPSTPVDSVATTKDIRPPVNCFFLYCAAFSELNKDKYKNRPELCKAAAQSWSALSDKEKAPYRAEAKSLKDHYTRHNSCPYRKQTGKQNAKKPQHRSEVKGKRPFPSAKRLNKKDDVQPSQKTRPDREPPTTSLPIIRPCDDHTRISSSHSETFGSWSGTSGWPIAPSAVFSPRPLSYSVSPNPFRYISRSPYTPSSMSSVISSPPSPSPYSAAPSPADSEYSDYHASPSMLSMYSSLPQSPSPSPYPAAPSPAYSGYTSPSILSMSSSFPQSPSPSPYPAASSPANSEYSGYHASPSMLSMSSFPQSPYPSPYPATSSPAHSEYSGYHASPSMLSMSSSFPQSPSPSPAPLTSLPYGSDPLASGFDYPSSNYYAWDPASSSWEHPGYHDVNDPLTDWLQSIGGMGGPSVVYQGARQDPSYGLTSQGLDAVHHPIIPSDATSFYRDVPHAGYGNDIAGSTFGYYDHLGPSTAGSQGLSMFSSGYTTAELDVQARAAHVPRISRIARGIPLSAWSNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4X1</accession>
    <name>A0A2R6S4X1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4X1"/>
    <dbReference type="STRING" id="98765.A0A2R6S4X1"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="196" mass="22383" checksum="287A8A28A252E141" modified="2018-06-20" version="1">MSVQHKILRTANAPTTAPDETEVNVAQALIDLENNVPELKAELRPLQISAAREVDVRGGKKAIVIFVPVPQLKAFHKVQQRLTRELEKKFSDRHVVFVAQRRMLRKPTRTSRVKQKRPRSRTLTSVHEKILEDLVFPTEIVGKRTRVAVDGSKLLKVFLDSKDATSLEYKLDSFSSVYRRLTGKDVVFEFPVQAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5Z8</accession>
    <name>A0A2R6S5Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000032">
        <property type="protein sequence ID" value="PSS37708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5Z8"/>
    <dbReference type="STRING" id="98765.A0A2R6S5Z8"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS37708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="261" mass="29110" checksum="A1562B9D6D123CCC" modified="2018-06-20" version="1">MSGQISKKRKFVADGVFKAELNDFLACELSEEGYSGCDVRVTHARTEIIIRATHTQEVLGEKGRRIRELTALVQKRFKFPENSLELYAEKVQYRGLSAIAQCESLRYKLLGGLAVRRACYGVLRFVMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAEDFVDYAVRHVMLRQGVLGIKVKIMKGWDPEGQLGPRKPLPDSVQILEPPLDKVVVEPTSEQREPAAVIPPAAPAPEEPAFQQQETFPSQYEQTEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6C8</accession>
    <name>A0A2R6S6C8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6C8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="60" mass="7096" checksum="E344F37B495D5BE1" modified="2018-06-20" version="1">MSKYSYEDPSCVPRFSLSTPPALTLQQSYICLFGIRLISVQILSQQFRMDWYALPWFRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S7A9</accession>
    <name>A0A2R6S7A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000001">
        <property type="protein sequence ID" value="PSS38143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S7A9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS38143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="80" mass="8509" checksum="AE4AB04D9C123FC5" modified="2018-06-20" version="1">MTTYISAIPHIRQMEEEVDNVHVQYTDPTSIRTNAGNVVLKVAGKVLALAVVEPEVLALANPVVIGARVNVPVNFSSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-05-10" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1U7KFH9</accession>
    <name>A0A1U7KFH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000561">
        <property type="protein sequence ID" value="PSR83378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1U7KFH9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="67" mass="7594" checksum="23EF92D6E5BBA8D4" modified="2017-05-10" version="1">MLASDAKHDDEGNDIRNPNGALIPVQYEPKAKDFMNPTYIPMHNYVSAECDLDIESVLLEYLVQVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDU9</accession>
    <name>A0A2R6NDU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDU9"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="407" mass="43284" checksum="95A50594B7AFDD73" modified="2018-06-20" version="1">MEFVARPLLQRWAGKLQPLLAINSSRLVLAAGNTIHSYAFGSSPGPEQSSAVKLECTYTTSAFHPNHDITGLVSVPDGGHNGTMYLGYADGSLERITLPACHKFPDSSVVLDASLRERYDFHEGSLIESLSASSTHVLSLSSEGTAVFLPFDSVDPSPEIIHLNTRSWSSYLSTHSSAPYAAFGTSSTSPLSVHTIDTSHIAAHPSAFLAPSFKPEGASAVYAITSAPPTSPWGGSDQIIVSGWYDGIVRVHDLRSSRRTISESSTPSLLPTMTFADPWSFEPIYSLACGGGSASHIAAGSARHSVVAFWDIRASRKGWSVHAPGNDSSPVYSLIVDGSRVFGANESRGFVIDFGEGVTDATYPPIAVLEAAPQTRRGRGAWSLPIEGPKKGSPGFYVTTYKHQNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDV1</accession>
    <name>A0A2R6NDV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v13583</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001349">
        <property type="protein sequence ID" value="PSR70544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDV1"/>
    <dbReference type="STRING" id="98765.A0A2R6NDV1"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="70"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="152"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="534"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="766"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR70544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="821" mass="91542" checksum="E9AFA6B36A63A507" modified="2018-06-20" version="1">MSGKRKSEEGGSIEITGREKKKQKTALARTIAVQPTRSPGSSTPIQNAVAGPSKSVQFAKLPGSLDVEKFTEARAFEINAMHTAMKTARATGSQRAWQQLPRHLRRRAASHDVRRVPLRLRDKAKSEMDPMRRKALGRSLPKRGKSRQLSRTAVLLKRQLNKAWLETHIWHAKRMKMENMWGYRLAVQPTETSFRPSHRASMHGSIIHDASYYGLLELKGSEHILSAILEMCSDPQGPSPGAKRRGLYPYGLIAPITVLWQALPINGQMTTQSSASAAPVDSKPGAPGSSKRKRKQKKGKEPEKVTSASEVKRLVWVKAHPSVFEEVFVEIKTAASFVLEAVKKAAAPTDEPSEVEIADLREHVNIFEITGPKASQVIHGALKPVGEDARPDFKKCWNALSDLQTTASIPRNMVIGFKVHDPRLNFPPKNAKVNIDQNSLPSLSPAATSFFPTSVLAQSDIWDESVRQPLRKPRYKKKDIDERKSKNLIPGTPIQAKDKDDRIPVLLIQRSLETPSTGPNHSHSTQSNSPSLHGWTLIVPSGWAMPFFSSLIFTGTRVGGQRERQTQSFEAGCSYFPRDYPGTESYDIYSEDREFEEKSLWERKPPAKRPNYEKLGSRSPWRPDWEVVLGLQDQSTGEELLAAQREQVMDVDNPAEATAEAEEGRIQPWLLRGPGAQAALDAASSMFNHCPGLLEHMNKLREKRKMGPLTVRADKLWQSAIVRVSARMCGRGRPEDLAVIYQMNDEEARKWMKAESMRKNGLAAMHENTEDETELSTVTPAQESIIGYITTGNFSLSLGEGSAIGAIPVARLFELKEQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEN1</accession>
    <name>A0A2R6NEN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001312">
        <property type="protein sequence ID" value="PSR70815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEN1"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="188" mass="20359" checksum="74C1E5450AE269B3" modified="2018-06-20" version="1" fragment="single">TLGMCIATSLGDALVLVVTWVKTARNLTEGARIGMRTPLSTMLLRDGHLSHLYSILFVMNIATVVVNTVPSFQNFDFVTTVIQTLQPILISRFLLNLRQVGSPEIDSQEAFNSQFSIPGFRVPSLSSIVGNMGEDLDHGGPVEEVEDEAENYSGSIQAEEGAAPEEIIEAHPSSMDPIPSTSHLIHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEW2</accession>
    <name>A0A2R6NEW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001322">
        <property type="protein sequence ID" value="PSR70788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEW2"/>
    <dbReference type="OrthoDB" id="2755889at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="183" mass="20226" checksum="64936722E6C93840" modified="2018-06-20" version="1" fragment="single">MNISSGKIISLDTTFKLTNKATVVTTDGKYTKPMKGGILNVINEKNEIIMHRLCQTQGAVEIEEAFQGLSTRCKVLGIPEPEEAVADNCCSVRNAISRALPQTDVSLDVWHFQQRYAVVILGGKKNPYRSAVIGDIVSAILKSRATKTRPAEYYKQEEQEENLVAAYRKWSNHGGVWSAAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG82</accession>
    <name>A0A2R6NG82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v12742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001286">
        <property type="protein sequence ID" value="PSR71366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG82"/>
    <dbReference type="STRING" id="98765.A0A2R6NG82"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015304175" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="117"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="691"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR71366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="846" mass="92356" checksum="7CC06C3B89E20824" modified="2018-06-20" version="1">MSSRAPKLVFVIFFALNCILWSQSRYAHIPRYASSPSISRRNLKEGGSLSGLLYVNGADYVDTKEECHPVTFPVKDQCTNVLESCPQPHTVLSQSYLRRYFCADPKFRPAMFAGYLVWLLFLFSTLGISASDFFCPNLGTLSNILGLDENVAGVTFLAFGNGSPDVFATFSAMRSNSGGLAIGELLGAATFITSCVVGSMCIIKPFKVDRGPFLRDVGFFTIAIIVLLVVLWDSELEAWESIGLVVMYFIYVSVVVFGSWWEKRQNRRRRLEAMMRDEFREENASDVPFINEPYHDDPTPAPVTDLYIRSRAVSTPGPPRPGLHLELPPRPHTRSSSPHSSHLFPRANTPPSPHGSHMPSFSLVGALEFRRVVTSLQHEAAGTALGLFDTPITPYPGGHYHQHSHSSHYRTQSSGSRGRTPALSTLDLVDRDPWDAALAQAVPLEHRSPRISCSGDVENTGELLSRHSLEDVVNSPLVPVISHTPASPSATISTELSTSPSSAAYVPPTKPQRIVRILSRVWHVLFPTLHNFRSKSFLGMIAALFAAPAVLMLTLTLPVVITDHDGGCSHEEKLVGDGYRGGYESPSVGNVGRLVEFEEEGVGRERTLVAEEDEDEDEESAVHELKFNKWLMAVQCTLGTLFCVSVLFDGTRHEPWLLLAAGVAGATFGVLVAVFATKGEHPTTRFARCTMGFAVAIVWVMAIADEVVEVLQTFGLIFGLSDAIIGLTIFAMGNSLADLVANMSVAVFAPIMGFSACFGGPMLNILLGVGISGTYVIRQTGKPYPLEFSTTLVITSTGLLTLLISTLIFVPWNGYFLPRKWGFALIVAYVVLMTANIVAEVLSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGE8</accession>
    <name>A0A2R6NGE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGE8"/>
    <dbReference type="STRING" id="98765.A0A2R6NGE8"/>
    <dbReference type="OrthoDB" id="2796738at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="123" mass="13678" checksum="0810577530AC10A0" modified="2018-06-20" version="1">MSDSESKSHPESVAEKGSDIHDNGGEGNISEIDLLDYHEHNAGRLVVDPEEAKIEFGEKVAKTLKLSPDGTKVLWPQPTDDPEDPQNWSDFRKNLQLFIITLAAIIPDFDSGIGKSPYYHSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH20</accession>
    <name>A0A2R6NH20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="7">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH20"/>
    <dbReference type="STRING" id="98765.A0A2R6NH20"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="27988" checksum="02FD7BFA77743BBC" modified="2018-06-20" version="1">MTPAERKKVNPKVVFFAGKAAPGYYIAKLTIRLIVNVARVINVDPDTKDLLSLFFLPDYSVSLAEILIPASDISQHISTAGTEASGTSNMKFCLNGGLLVGTVDGANIEIAEEVGESNVFFFGHLTPAVEDLRYQHMYHPVPIEEKCPALAQALNEISSGTFGDGGVYEPLLNTIRQNDYYLLTEDFDSYIKALALVDEAYQDRTEWIKKSISTSAKMGKFSSDRAIQDYAQECWVRSFLDNSKDINLLVITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHQ3</accession>
    <name>A0A2R6NHQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v12279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHQ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NHQ3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR71778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10158" checksum="6B0073C65A3F8B28" modified="2018-06-20" version="1">MSAAPSTLTAQTAEQAPVLFKLLLLTFALAFAPISVYYLSQNYLWNGNSTYAAITAVVAANIVLVTYIILSVMEENQLTKASKGTAEPETKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHT2</accession>
    <name>A0A2R6NHT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHT2"/>
    <dbReference type="STRING" id="98765.A0A2R6NHT2"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="185" mass="20886" checksum="E44D5F49E4CE9987" modified="2018-06-20" version="1">MSQGYAEYALQEPTKCKVVAIAEPRPKTRKNFTDAHLVDQTLVFNTWQELHKASEETLKTVGTRLADAVLVTVQDYMHVEVVLAFAEQGYHILCEKPMSTNIEDCIKMEAAIKKAGIIFGMGHVLRYSPYSKAITEIIRSGTLGQLINVVHVEPVGYYHFAHSYVRGNWAREKESCFSLMTKSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIX6</accession>
    <name>A0A2R6NIX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001230">
        <property type="protein sequence ID" value="PSR71962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIX6"/>
    <dbReference type="STRING" id="98765.A0A2R6NIX6"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF28">
        <property type="entry name" value="OS04G0488500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="719" mass="81039" checksum="2258452B0A6944CE" modified="2018-06-20" version="1">MDAINYVVESGSEDLFKVLFEDIVTSYRGRQNRDRIPVTCHLLSLTCDDRWKKMLGRDRLLRILRYLEARELLRRIPTHILYGCTQAILNRRPIATDVPILTLLTPVLLYRLDESKIHNNLTDSTPNIVWLLFQGMQRLLQLKRPSQVLEIFQKLVEKGDIPASALEGVDVTSGNFDHIIIAVLVRCCLQWGWKDRAINMVQFSLDRGARLAHALCDVAVNVLEVLLTGTEAHAEQVTSILTGLLSNAEDGFTIPHEVLATFYDHVRLHRARDAASDIYRLTRSPQVSEKHRYPPPLQSNLVWVLQNAFRNRDVHVARLLAKQIVEDDVEIPYLARPNMISQMASFGFTLEVRALWERYASRGDGIIIKASAGMLTRIISLCIGRIRILENRRRMVEGKQTLVESLALPVGDSMTPPSPDGSSDGATSQTTDVLIDPITAGEDLEEGHETMSYEERIESVRAFAGRVMDTFIESIGSLQHASHFELNALSRAYFQLNKIREGFDTLKIILDRKEIPDPHDINVALSALSAHDPREATQMIQRMVDLGLTPDSVTFGTVIHHAVLHNDSALVTRLIKLAKRVGVEHLDYKTLGTLIRGAVTEFGEDDPETQLRTAQELMDALLNAGFVPSPAMGMDCILAALHASDPVAAFKFWKLIVKDKVDWKDSKQVVYRARIARAIRRYYKEKSLDPDKSRAMLSELGVDPSLERRYRQNAAATQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ15</accession>
    <name>A0A2R6NJ15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001193">
        <property type="protein sequence ID" value="PSR72359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ15"/>
    <dbReference type="OrthoDB" id="3225366at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="51" mass="5637" checksum="36C9D4DC15D037C0" modified="2018-06-20" version="1">MSSAQIGTLRTKVDYKLPETVQSLVEGWLKTFESSAVAVSIHEKLLWSGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJA6</accession>
    <name>A0A2R6NJA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001180">
        <property type="protein sequence ID" value="PSR72433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJA6"/>
    <dbReference type="STRING" id="98765.A0A2R6NJA6"/>
    <dbReference type="OrthoDB" id="2736611at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="568" mass="63250" checksum="FDC4D32BE68E4CE6" modified="2018-06-20" version="1" fragment="single">QYKAQFTIRHVINTGPSTISTRGDPNWNMALTIARLVIDIWQTEMKALVRANVIAEIMILRTSELTEDLTSAAVKTSNLKKWLACKYQFNYKDQSYYHLIRALIADKDLLPLGLPKGTVATMSRKSFVKEMLHQATKPKPAAPLLKKGPLLPLIQDASKEIARLCSILQATPQDKESWTMDALLFAVQDAQILFAPWIPLPNTHGGRPASKPSHLAWISFSTPPPPNTISSSSHLLRIDPAEVLTSQLSALSQQTQSDDANGHWSAVEIRLCDLPSIFHKTVPPDEWCIFYVTQAQQIYGPKGTAADSLVSETYTWAFNVFDMNNPVHRLALYTSIIVSKMLPNIFNPFAGARVPAPPLAKTATVPEILRSVREVDLCDLPRNGHGEAAPFIFMVTMYCIAWTYQESPLRKYVRNSSGFGEPWANKHSNKGVTPFLLTRFGWTEPSVTIFKSPRPMQSFRPIPPEAHVIRYTSFITKASQDPQYGMFHAVAYLAGITTAVDLSSRCSQYRSPPVHISMPSLASKRTQSNISLSDNEDEFIADTPAAALSSSTHLAQRSTKRRRFASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJJ8</accession>
    <name>A0A2R6NJJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJJ8"/>
    <dbReference type="OrthoDB" id="2802986at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="332" mass="37284" checksum="2D32F99E74D6FB5E" modified="2018-06-20" version="1">MDRSPMHRVPAYVETIAPTSLAHRSIRNRLPKSTRTQRALIRQCYRQGNKMISEIAEYAGCDARVVWYAIHNEDHDNLEEDQAYVDGKMGEVVDIAALDVSEIMARMEEMEAEEVDEKLDGMIMLDSDDNPFDAELETENNLSQLPLLPSSPTETSISRRTDYSRESSLSSLTSLESQVVQVIVPQSASAGPSIERRIQKRKPLIGLKARNTKRSRPTPPTTTAMPASPSISVPTSSTSSTLNASPFVSSKTSDYAVETFLHGLESPSDHLLQYFFEMEIDSASNLDYVCRMEEEFLDEIKTHLLSKGVSLFRWLIIKKGFRQRAANLPPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJY1</accession>
    <name>A0A2R6NJY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001140">
        <property type="protein sequence ID" value="PSR72685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJY1"/>
    <dbReference type="STRING" id="98765.A0A2R6NJY1"/>
    <dbReference type="OrthoDB" id="2795455at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="126" mass="14230" checksum="F311FE2D56CDEE01" modified="2018-06-20" version="1">MADTVESPIPFRPNNFRWVPSWIGTAKKWYECEDGFAAKARIAEDYKEIEIGRFFASEVLAKDARNHCVPIYSALQVPHDAGITIVVMPFLRSYDEPSLQTIGEAVDFFGQLFEVVSSPTPSVTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKX2</accession>
    <name>A0A2R6NKX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001119">
        <property type="protein sequence ID" value="PSR73035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKX2"/>
    <dbReference type="STRING" id="98765.A0A2R6NKX2"/>
    <dbReference type="OrthoDB" id="3251271at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="228" mass="25405" checksum="5E72CF5D56A67F60" modified="2018-06-20" version="1">MSKTLSNGTLSLRFMQNAQRAKQQAQVELEQAKIKDDAEWEMPQEVKDAWGIGSSPDTTRSSSVTHESSYLPFIFASSMDESSSVPDARPRGRRKFNERGQEVKPVDEPPPEATDVIMEESQPSTRITSISGFKVPIPIKQKDKKVKMKTAQELIREDAIRQPPAGLQTPQSAAGFRMPAGVDAPAARTNTTRREGHPRLKRERSSESGDILGSEGKKRKKKDTRMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL84</accession>
    <name>A0A2R6NL84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001104">
        <property type="protein sequence ID" value="PSR73137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL84"/>
    <dbReference type="OrthoDB" id="2804471at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="130" mass="14400" checksum="91BBA221F28C07E3" modified="2018-06-20" version="1">MSDPTDSAQITEELQILCIGTAQLVNLVNLSQYIVFALFSALRAYAIHNFNIAIFLAVFSLNVIPVGTNIVSCRFMTAMQYYLMSVKSIPTFERRRLTSVGSVPSPPAYLPISVSTVSTQHSLHRTLLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLG9</accession>
    <name>A0A2R6NLG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001096">
        <property type="protein sequence ID" value="PSR73205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLG9"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="618" mass="67526" checksum="D2817DD082C3F0C3" modified="2018-06-20" version="1">MSSLEPGTAAYIPSVLARIREVHPDLPLEPVIVQSLLICLVAGDPSAAHGHESDYAASRSSKNLVLRTNEEDVGLVANLTELILTTVFGFPTHKRKLKKHPQDSTSLLGQRHLFATEPSDTFLRHLFFRGKHASRLSIGGDSQRSRKIGNAHERKRSSTLPQPSPVTHDISLPPTGSSPTHTREGTIESDFDVTSLGSSRRVLLTPASTLRMRPQAPRMQTEPAMFLPPRLKVQSPDASSQHSTLSATLPKALVVSGLENVGVPAQRSLLQVLHEHKLVLGGLGYAEDAEDSGRTWNLPDDFLVVYVCPTDTASRPPILRSLDTASSSHSPLLRTTSLAPSYPGLSTSPVFSAQELSYLRSLTSPPPPYLPLPNDPKAESLPDAYTSIHSSLKMYLADLFSAARHHPLLDGTMLSLRAHRDAEDLARAFRVICGNTIGAELVTEVAAMASSDEDSRHSRDARVDNGTFTEGDEESLEWGKVHEDDDFLGVELEKGKKKASSVRSVEVRIQAPDSPEDVGPFNPESLVHHNIRTGLSPLPLREPQIWDVSEVDIAKIFPRVVSHRLRTRDGPDDEILGSLMNPAVHDSIPPGFTEVSKRRDNMDKKTVKQVLIGILADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLK8</accession>
    <name>A0A2R6NLK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001094">
        <property type="protein sequence ID" value="PSR73258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLK8"/>
    <dbReference type="STRING" id="98765.A0A2R6NLK8"/>
    <dbReference type="OrthoDB" id="5395091at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="453" mass="49639" checksum="AB96580DECD47BD4" modified="2018-06-20" version="1">MSGEILSSHFRMVFEETLSPARQRQAVDALKDYIAELKYGNTEQRIELGVIDTDDALVDAKVKAALDRCYSQLVVFLRFSTPSRLAEAEPYLRSLLHGSPSSTAQEIHTCLYLAAALSSSPACSYSSPRPSSPSQSFSSAASDTPNHRPTPQNDKLTALDRDQEALALFTHAFSLYDTPSSHNPSSPRLLDERPRAACPSPIQAPVRRSRALPPKTELWARAAYARLLRRMAQHTAAKEVTDVIRTYIASHPYALPPEKYDTFVQDLEAEFGLSLGPHSLSDDTTDETPGVKPNATLPHTENSLHNLLAGSLSGDPIDNSLHTTTTDETSGVKPDDSENAHNPADDSETDSLLSSSPRSTSSHLYSSSSSNSSGPNSPVTPSTELLALALLPVALRIHRHEDPEPDAPSRRLEHRRMRAFEREGESRNGKMLERLESQTKTSAYTNTVRYGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NME1</accession>
    <name>A0A2R6NME1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NME1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="173" mass="19212" checksum="8B7A94870AA7DD6D" modified="2018-06-20" version="1">MSGPKKSSNSNVVLPGFQEAFAEPPKKGWIAQAILTHPINYRATKLLHVAFRCLWPLEQANLDIFLTDVPPSPPVSGRQTGHRCNSSPSATASRDTQPPSTSSPSQYRDSASASPVASSTRSDGDDEEFPELVGFQNLRRRKRHICPVCNKDFLRYLMLSPQSYHHDPLSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMI9</accession>
    <name>A0A2R6NMI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001075">
        <property type="protein sequence ID" value="PSR73497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMI9"/>
    <dbReference type="STRING" id="98765.A0A2R6NMI9"/>
    <dbReference type="OrthoDB" id="3211671at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="390" mass="42907" checksum="0D755E0EE7A698FD" modified="2018-06-20" version="1" fragment="single">ISSVDKFNSYRGSGTTAIFEAVWRSGDRTWVPYDAVKHLLAFNEFLAALGVGDAKDLPEGTGSPPPDDPQVFLGCMVLDPPSALIRPPYSSKSTHGRVCRDSRLHAVISRPPCALLFFRSHSPILLSLSLPTDLLATLVCLLMPYRHPRLSRRSDGALVLESKGCHYSYPLNELTTALFFDSQLREHRVQVDNTVMPGFYDGLALLWNSLDGCRFKLATFDAEAKQAIMAGPPIPRIEFIPTQFAHASSSMDASTSGTIITPDEQQHLLLMAAREKMRLDRRKFQGIADRQAKRALQPETRQPSSKASQRVRERIAEDRERRLSNPALAAPRDDDDELEDYPPDDEPMGEALTPAITAAVAASNMEDMVVSPLDVGKQGAKAGLKGKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMM9</accession>
    <name>A0A2R6NMM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001086">
        <property type="protein sequence ID" value="PSR73290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMM9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="107" mass="12315" checksum="96F5D78FF65A649A" modified="2018-06-20" version="1">MSLHWLHLVNNRRNSFSVIPALPSKSIKRMRWKLSHQERDEGDSRVVPVRPAGRYGNIATKMILRDWERRIYSCCGAHLVEGLLALHHFQHDCLVTTVDNGLKTSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMR4</accession>
    <name>A0A2R6NMR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001084">
        <property type="protein sequence ID" value="PSR73333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMR4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="97" mass="10133" checksum="44154D7DBD96F6DD" modified="2018-06-20" version="1">MGRARNGLPNGTPKVSLDSPAGPTSSHSGSSHSHRPLSPTHASTGAPDALNTSTAHPVQGPHDRGYATQPMTRTRTRVSELGVTGSFGSYELLEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN14</accession>
    <name>A0A2R6NN14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001062">
        <property type="protein sequence ID" value="PSR73780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN14"/>
    <dbReference type="STRING" id="98765.A0A2R6NN14"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="279"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="377" mass="44106" checksum="0F07AB64194AAD0C" modified="2018-06-20" version="1">MPTAQPQTLAFTAHMPKSRKLRRLVSDYCLKLSPRRRLVQQEIDIPPLPPPKDTVVLAGGKHSSYADLQQDYAAHIVFLAQHEPPFALYPGNTHNRPVQTRPPGHTPAFRPQCPQSLLLPKTAVMPRMMSPAELRVRRMEAANKRDTAEHEVVADEAERQARLKLEKEMLRNQMMEEENRRKRELEEELRYAAVLRSAKEAREKREEEERRKILEERRKVDRERRLQQTKRLQEWRDERAKQAEDVVRRKVEMRQHIQEERRSRPVLRNMAGGQHDCFDGWVTIQIHGSVTWRRRFCRVQGGHMRLFKDTRCTQPLDTVSISSVQKVKECSDGCEELEGLPFSFALDLSDGSSYSMFTDCEEEKELLMTLIIQIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNE0</accession>
    <name>A0A2R6NNE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNE0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="57" mass="6022" checksum="9E448EBDE7549D48" modified="2018-06-20" version="1">MSTVTIAPLEEKVAVLDEKAAKAGSSSTRDYMMKFVCAAMSKSDLNPPGPTTVTNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNG1</accession>
    <name>A0A2R6NNG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001043">
        <property type="protein sequence ID" value="PSR73957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNG1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="113" mass="11946" checksum="4FF449FC478A3786" modified="2018-06-20" version="1" fragment="single">GIVPLSPTQTAAHLPEESEPTQSSPTKRARTNKEEASSNAPLSQCPRLVSVKEEPGNGGPEPPVINNPQNPTLAIDILSQSGSDNQPHLTNTSFTNALASDARENIKSEPEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNG6</accession>
    <name>A0A2R6NNG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 12">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v10505</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 12"/>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNG6"/>
    <dbReference type="STRING" id="98765.A0A2R6NNG6"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR73586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="359" mass="39658" checksum="8C539FF4C7B2281F" modified="2018-06-20" version="1">MKNDLLLRAARGEETEHAPVWVMRQAGRYLPEFRSVRATHEFFEICRTPDLATEITLQPIRRYTGLIDASIIFSDILVIPQAMGMEVLMNPGPHFPDPLNTPEDIAKLSKDVDVNQELGYVFKAITQTRLALDGEVPLIGFCGAPWTLFVYMVEGGGSKTLQKSKSWLLKWPEESKALLVRIADVCVEYLVGQVKAGAQLLQIFDSNAGELAPHHFAEFSVPTLQRISAGVRSKLAEENIPAVPMTLFAKGANHALGFLAEHSGYDVLGLDWCIEPSKARALVGDKVALQGNLDPNTLYGGKEAIEREVKRMCESFKVGGKTKGWIANLGHGITPGVDPEDLRWFFECMQKYSATASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNS4</accession>
    <name>A0A2R6NNS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNS4"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="6570" checksum="AA1B971E9F64EFC4" modified="2018-06-20" version="1">MFCHDVIRADMEHLKRTPCRNALLGSRHLGEQVLSDEYDQTEDHGRVEDVFGYHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNT9</accession>
    <name>A0A2R6NNT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrroline-5-carboxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NNT9"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="192"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR74112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="27685" checksum="3E24A585D819C38F" modified="2018-06-20" version="1">MGIAVLSGVIASLDSKVDPQYPPAAKWESHTPGTVTPVIPQTDESQPSRFIACVSREESAKRLRGIFFNLGGLGPSVDVLVAENVKAVQQSDVILLCCKPQLAQTILSEPGLKEALDGKLLISILAGVTIIQLTAMVNPGTKVIRAMPNTPCKIREGMTVVSTIPQSPSMDLDCKIILNIFSSIGRCRFLDEKHFDACTALSGSGPAFACIFLEAMADGGVMMGLPRAEALELAAQTLQGAARMTLQAGTHPAQLKDAVTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNU0</accession>
    <name>A0A2R6NNU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNU0"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="7075" checksum="3BCD0D1FD14F31E3" modified="2018-06-20" version="1">MRRTKTFIHDREPSWIFEKGFTENDELWTPTNRETSDEQQARSREALVEILNNDDSTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNZ6</accession>
    <name>A0A2R6NNZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v10117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02001019">
        <property type="protein sequence ID" value="PSR74161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNZ6"/>
    <dbReference type="STRING" id="98765.A0A2R6NNZ6"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000215">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="43"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="201"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR74161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1112" mass="127898" checksum="4CC607D511F6CC81" modified="2018-06-20" version="1">MEVLDEKVNGGPPMEVEEIVSVRDHDAFAAKHMPDLGHDVKEFKVSSWRLTNWKKLEKKITSSEFECGGHKWRILLFPFGNSNAPPNDTVSVYLDYADPKRAPEGWHACAQFALVISNPHDPTIYTVSHAHHRFIAEECDWGFTRFSELRKLFSIQEGHSRPTIEDDCADVSVFVRVLEDPTGVLWHNFVNYDSKKETGYVGLKNQGATCYMNSLLQSLFCTRYFRKAVYQIPTEDDHPTESVPLALQRVFYHLQTSDQPVGTTELTKSFGWKSLDSFLQHDVQEFNRVLQDKLEIKMKGTKAEGANAKLFVGKMKSYIKCVNVDYESSRIEEFLDIQLNVKGMKNLYESFKDYVAVETLDGDNKYQAEGMGLQDAKKGIIFQSFPPVLHLQLKRFEYDIQRDAMVKINDRHEFPFEIDLGEFLDETADRSQPWVYKLHGVLVHSGDLHGGHYFALIKPDRETRWLKFDDDRVTPVTDREVLEENYGGEAINGLISPMQRNQARAMKRFTNAYMLVYVRDAAIDEVLAPFKEEDTPPHLKRRLDEERQQVEAKKREREEQHLYLTAKVITDDTFNQHEGFDLASFDDRNWPASELPTFRVLKNETYSTFKARVAQHFNYPETQIRLWVLVNRQNKTVRPDTHIPENEPTLTVEVIRNNMAVRQQNDLRLYLDVIADPSRPEVPPGSIMIFLKHFDTSKQTLYGVGKMYVLRSSKVGDLVTLINEKMRWPPGTPLKLFEEIKPGMIEMMKLKLTFTQSEIQDGDIICFQVDINDKEIHDLENQGLYSNPTQYYDFLQNRVMIVFRPKFEEADQEHPEFTLVLSKKQNYDVMSGKVGEYLKHDPIKLRFTTTHATNGSPKTVIKRSLNQSIAEIISPAYAGTQTTVILYERLDVSIVELETKRSLKVVWTGSHNKEESTHSFLLPKTSMVHDLADHLAKQVKLAPDGTGKIRVFEVSKDGKTQKEFTGSEMIGNIPDPVELYAEETPREELDADDSDKLISVFHFSKEVSRTHGVPFRFVAKPGEKFADTKKRLQARLAVPDKDFAKYRFALIQVATFKQPSYIEDETTLLKRTVEDTIYDHKFAPEDVLGLDHVDKSGKTRSGAGEKAIVIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPA3</accession>
    <name>A0A2R6NPA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoketolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPA3"/>
    <dbReference type="STRING" id="98765.A0A2R6NPA3"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="600"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR74265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="89800" checksum="8A2A58F229AB7877" modified="2018-06-20" version="1">MPGEEIYVANPPPDPSHLPDEILKFRVQLNTRDVIPEKELHAIQEFRRAADYIAAAMIFLKDNILVERDITADDIKARLLGHWGTCPGLSLVYAHANLLIRKTKQEMLYVVGPGHGAPAILACLWLESSLSTFWPKHTRNRQGLHNLITTFSVPGGFPSHINAQTPGSIHEGGELGYALSVSFGAVMDKPDLVVICVIGDGEAETGPTATAWHGYKYIDPAESGAVIPIVHANGFKISERTIYGTMDDKEVTALFIGYGYQVRFVEDLENIDQDLAASMAWALDEIHKIQKAARDGNPIIKPRWPVLILRTPKGWGGPKKVHGEFIEGSFHAHQVPLTEAKTDPEERKALQKWLTSYDPCELFGTTGEPNQEILSIIPEENHLKLGQKKEAYAAYTPLDVPAWEHMGVEKGTQASCMKVVGEYLHDVIEQNPSTFRIFSPDELVSNKLDAVLRDSGRNFQWDVASRAKGGRVIEILSEHTCQGMLQGYTLTGRTGLFPSYEAFLGIIHTMMVQYSKFVKLAHETTWRQPIGSLNYLETSTWARQEHNGFSHQNPSFIGAVLNLKPTLARVYLPPDANCFLSTVAHCLRAKDYINLMVGSKQPTPVWLSPEEATKHCVAGASVWKFASVEDGVDPDVVLVGIGVEVTFEVVAAAALLRKLLPSLRLRVVNVTDLMILAPEGSHPHSLEEADWDALFTSDKPVHFNYHGYPQELRGLIFGRPTIGSRVSIEGYREEGTTTSALDMMLQNHTSRYHVAQAAVRSASFMNQRVQVRSHEVISELKHRAEKDKAYIYENGADPDGTFDVPIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPJ0</accession>
    <name>A0A2R6NPJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000995">
        <property type="protein sequence ID" value="PSR74345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPJ0"/>
    <dbReference type="OrthoDB" id="3256751at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF17">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="136" mass="14353" checksum="A75214214AD85339" modified="2018-06-20" version="1" fragment="single">MFSAVSNLGAGGTQDVALSDESQGVLYGLFALTGLISGGINNLLGPKITLFIGTLGYALYVGALWCLQTQGTRWFLVFAGAMLGITAALLWSAQGSIMMSYPLEKDKGKAFAVFWAIFQFGSFIGSVIALAINIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPJ2</accession>
    <name>A0A2R6NPJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v10203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPJ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NPJ2"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="68"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="283" mass="30983" checksum="21460DBC5965EAB8" modified="2018-06-20" version="1">MSSAALPPFDFSPAKAAYTEKPHPGWVLGQRTESTPDGKEWVEGEKEGWKVIDTSKEDPMKLYALMISGIIPRPIAFVSSVSEAGVENLAPFSWFNMVTHYPPVLSISIAHVAGKLKDTPTNIKATKNFVVNIISEPFVEQANITSIDCPPEINEWDLSGLTKVPSDIVKAPRVKESAFSMECELFQSIDIVHPDTGAATTTLILGLVKCIHVRNDVLNERGVVDVAKFKAVGRLGDISYSTTGTPFRVAREQWKIDGEKISEFLKGLQNSGLGTESSPKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPJ3</accession>
    <name>A0A2R6NPJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPJ3"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055412">
        <property type="entry name" value="UVB_sens_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24160">
        <property type="entry name" value="UVB_sens_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="10"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Root UVB sensitive protein C-terminal" evidence="8">
        <location>
            <begin position="175"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="297" mass="33268" checksum="8D2D6F3024357CB5" modified="2018-06-20" version="1">MHFAQPANGSRQGDIGDLSAKDGSKETVLALVGMLCGFAVMPHLHTTYATNGLLFILITGHLLTNYIAVRAVALRSLNRQRASILWSTYRVTEIDDKGTNARIMTPGEVASEEFLFTCPSAIFYPSSSDTKRIAGYCSIGSSLSSILPSTQSRPNLFPWITLEEKRWILTRDAARFRKVLELFKDEKYLLWLDPHLRKNHPHVHVILKEGHGPLDHLKAWLHASELLAHLGSFQGPSNALDLMKNVQDSKEAIEAEFPPFVEKSRDAGWNIDENGYGLVAGSPRTITIDEREYRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPS5</accession>
    <name>A0A2R6NPS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000976">
        <property type="protein sequence ID" value="PSR74529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPS5"/>
    <dbReference type="STRING" id="98765.A0A2R6NPS5"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000202">
        <property type="entry name" value="Small ubiquitin-related modifier I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10821" checksum="CA18779B267E4309" modified="2018-06-20" version="1">MSDNERPDNVEPKAEDANAPINIKVTTQTGDEVFFKIKRNTKLSKLQGAYANKVGKDVNSIRFLYDGNRINDDDTPASLDMEDNDTIDVMVEQVGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ10</accession>
    <name>A0A2R6NQ10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ10"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ10"/>
    <dbReference type="OrthoDB" id="2803645at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="616" mass="70579" checksum="83596E43359B861A" modified="2018-06-20" version="1">MLSVFDLLPQQAKDLVALFRLSSREVTPIVAWHALGDKPSPVPIILAIGILSLVALSLPKSAHICLSTPSWIKGPFASRRLYASQAAQNHDRHKLTVENLNKMTRVCRSLQAELKERDYSLRETQSLMESTPRHLDPENGRLKVYNNKLKSDKARLKNELDDQRHTHSRQLHDSTQEKESLIRRVRSLEADKLSVAANFEGALRKLAEENVILKHKLLDQERHRAKERKVQDRRLSSAESKLEKMKEDNESLRRQLLEFQGDNNRSQQTQSQQLSVKQAEFIAGLEKVKRQLVEQQEQHIHQQEILIRQISLARNDKKAVEVCSLNTLCIRIGVELNKSLKAQLEDARNVARSKSDDVARLQSQVVEHEDRVVEEYSSFSEDLKFMHAESHYERRMYQKRLSSAQIESSTLRQKLSDIVSDYEEQSTVLGATQSDLSQASSLNEEFYRRLEAALAQKKVADDLEHLLTEELRRRNDEYETLEISFDVLESAYRFLATECVRTEHALKDALDVQEQLREQLQVMQECIRSRAVSERDEETTSTFSSYSERSWPATPGLTRTPDASSRYTYSPTLATPPLPALCLDPIPSIDDRLTSVPSLPSPSDLFDSWPLPVGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQI7</accession>
    <name>A0A2R6NQI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQI7"/>
    <dbReference type="STRING" id="98765.A0A2R6NQI7"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08254">
        <property type="entry name" value="hydroxyacyl_CoA_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="25"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR74830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="362" mass="37906" checksum="30F03D80D9BDA7E7" modified="2018-06-20" version="1">MGISKSTAPKPAADGNMIAYRYRPKAQAPVREEIPIPTPGPDEILIRVLAGGVCHSDVGILDPNCLGDAITRTCTMGHEGSGLVVALGSSVPSTHPELIMGSYVAVYCVDSCFKASCYACRTGRDNVCPNGTWIGLGSDGAWASHCVLRAVLAVPVPGNILTIPPAVVAISTDAVLTPYHALKTCVNLQPEQTILILGAGGLGLNAISIAKHCLNARYVLASDKRESSLAQALEMGADHAVLVDGLAGFLQESQTIVDIVVDFVGTQETFDIAVSVIAPGGRIQVVGLHAKTLQFATSVLMGKDVAIGSNFCGTKAELVEVLAAIAEGRIKPKVETRPLDDCVQVLDELRNGRLKNRVALIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQS5</accession>
    <name>A0A2R6NQS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQS5"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="396" mass="42824" checksum="D481FF6DCFD9944B" modified="2018-06-20" version="1">MALPSRPNVRAGLPSNPRSRSVTAGGPRYDLPPRPESAASERPSQRVRTTSSPSNPPPQLRTQRSLVDLSRSGTTSRRSERTKQDVVPPLPPLPPSNATSSSKSSRFYGTRQGSVGSIGTSTSSTSSEPNSLQSYPSYASSSTSLEDMTNEEMKDDMPEKLAPGFGSSLWSRVAAAAGSLTVNVSKAWQANVATYNGEVTPPGQESRLIRAMKAYHIEKAREPSDLPEWLFDERDRGVSSRARLDEGSPEADIHSPTQPVIPQPSRTTASSPTRPADNGRTQPKQQWQDQDRDNAVPVSKATQRLREMTAAKRNPTIRFAEAVHPRRTGAGNNASVDSEVGSDEQRRPPLPLPVHRMPDPGSSQTPRRAPTLANVDVKGRRPAAGGLPSGVRPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRH9</accession>
    <name>A0A2R6NRH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine-protein kinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRH9"/>
    <dbReference type="STRING" id="98765.A0A2R6NRH9"/>
    <dbReference type="OrthoDB" id="3352225at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="357" mass="40898" checksum="F9944450A15616DF" modified="2018-06-20" version="1">MDLSPGQEHITFALSRSAPRTQAFLDLIEKVFRREAAIWRHLKHSNVLPFLGIDDSLFPGATCMVSPWMRNGSLQEYSAARDRPLLDSEVHRLMYDGRKPFKDRKSYQILAAVLHGERPPRNSSQRPIPDQMWKLMSACWAQQHDIRPTASIVKRYLAIGWYRSPSSLKKAVQPKLELHPLLLPQPALNHFIDNSCGSPFLIWNMLLPPDKLNKPNTCSHRVWMEGRYSAATWPRVGFLKFTSRHFPWELTVTAGSPEIGLTCGDVIEQIYSFMNIPITQQEQDGASPRQRIVLSNTYWRNRAEDSSFLSPQQEVSRCDWLGPCTMFGGLMEVHPGGDSWEGTEDEQHPIFELKCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRN0</accession>
    <name>A0A2R6NRN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v9167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000904">
        <property type="protein sequence ID" value="PSR75409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRN0"/>
    <dbReference type="STRING" id="98765.A0A2R6NRN0"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="281" mass="31325" checksum="B4D6794D74C24FD7" modified="2018-06-20" version="1">MPSLTIPLLDGTSVPWLAFGSGTALWQQDAAEQVSNAITAGFRHIDTAQMYANESSVGEGIVKSGVPRSELYITTKLDKLPAGQTVKDALKDSLQKLRTDYVDLFLIHMPLDHPDLKGTWKQMEELKAEGLSKTIGVSNFQPKHLDIILDGASIEYNPYLYKATQPLLEYMKKHNIAAMSYGGLGPVTALPNGPAEHIFEKVATRLSEETGVQVTKAQVLQIWLRKKGVICVTTSRKKERLQEYVRVSQVPDITDEEEREIDQEGSKAHHRVWATWIDEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS26</accession>
    <name>A0A2R6NS26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000917">
        <property type="protein sequence ID" value="PSR75213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS26"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10749" checksum="04AE40B6018FD969" modified="2018-06-20" version="1">MLNLRRVYLCEEVSTVGSIHLSRFSSLRFSTSIIVGNLGAPLDLRSWQPDNSRLCLDFEDGDEDKIIFSDDPLVADLLEDKDVESIGSWEESEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSH4</accession>
    <name>A0A2R6NSH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000872">
        <property type="protein sequence ID" value="PSR75871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSH4"/>
    <dbReference type="STRING" id="98765.A0A2R6NSH4"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="144" mass="16601" checksum="0726DE062709EB5B" modified="2018-06-20" version="1">MGIGRLESLEERLTHKSAEVTDKEVEELARQNAATRIQRAWRAKRRASYLGTDFLWTDLATHARFKVGFSITIHNADTQVSPLQVDRNAAIEGKNTARERWRRAIFLALRLQDGNQMLADNRVEDADVARKYLETQHWLELIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSJ1</accession>
    <name>A0A2R6NSJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000888">
        <property type="protein sequence ID" value="PSR75503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSJ1"/>
    <dbReference type="STRING" id="98765.A0A2R6NSJ1"/>
    <dbReference type="OrthoDB" id="3251181at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="264" mass="29782" checksum="5276E1A9CDEF557E" modified="2018-06-20" version="1">MADTKVHAEDGRTYTEIWNSGATAHISPYRWMFDSFEEHTETIYIADNSTIQVVGHGTMVICVPYKNGWRKIHLLNVLYSPSFRCTLVSISRFVSKGFNILIDAEGLHLHALDNTYLASIPCRNGLYRIDHTAPDSAITPMAFLIKRNKVPLYDAHIRNGHVSYEYIKKALDSDHKYLGLQIDPSKMEEPLCEACVKGKISCAPIRKEHISNRAVNFGDILHMDLWGPSPVCAPGGLQYTFTILDEATGWLYEPKMCTKDKAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSU1</accession>
    <name>A0A2R6NSU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSU1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR76036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="166" mass="19045" checksum="DBAB03617D0E5A22" modified="2018-06-20" version="1">MSPVDNDKTSYFLTSLADSVPFPAPGFPNISIRRTLPSAWLFCASAVDALELLWRENGRAFWDDDDLPKPRECPGWRTWGVCLGRSKEEDAGQRMKADMYNNNERTERRKIKENRCQGPMVQLYVCPNRTGSSDYSPMGIIAPLRFRPGIRTSARAYQCQHRELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NUK0</accession>
    <name>A0A2R6NUK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000825">
        <property type="protein sequence ID" value="PSR76922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NUK0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR76922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="313" mass="33986" checksum="22868E2FE5CFD7BF" modified="2018-06-20" version="1" fragment="single">MPRKRKSTPPPPLQTCTKNKSTHPGLPDLGPPRRPTEVVQAEKVTKAKAQAEADATQMSAIEAVAAVENRMQIDNELAEKEGNHPGPPTRHLLPRAKQAKPAEISQNLNLVETAVTLTNLSWVRMRMWRKSEEVVDNDESDSSESIELAQGRGKPKKHGRADVIAARHTKLAEKGKEAAQRSTPAVATKKTTQVKSLRAGVSTGLVDGWKSVVQRPGGHSTSSISSRSCSSLPPLSSEGDTTDDGIHLGTFADDHDAAEHKGLDSSEEYWTRPVSFGLKKKTDGAYYAPNPRSSRELSQDAIEVPMKDPKTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV14</accession>
    <name>A0A2R6NV14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000803">
        <property type="protein sequence ID" value="PSR77292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NV14"/>
    <dbReference type="STRING" id="98765.A0A2R6NV14"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR77292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="238" mass="24795" checksum="9B542B060E20F331" modified="2018-06-20" version="1" fragment="single">NHAGALALAARERGIGCFVVMPLNSAQPKIEAVRSYGAEITFCEPNAPARESTLKMLQERTGATFIPPYDAVNTILGQGTALLELIEQAPEPLAAVIAPVGGGGLLAGTAIAADGTNVRVFGAEPAGAADCAQGLADGRRIEHVNAETVADGLRTPVGKLNFPIIQERVEGVIVVSDEEIVQAMKLMWERLKLVVEPSGAAAFAAIRSKAFQELDIKGPVGVIVSGGNVDLSKPLPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVT1</accession>
    <name>A0A2R6NVT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000771">
        <property type="protein sequence ID" value="PSR77842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVT1"/>
    <dbReference type="STRING" id="98765.A0A2R6NVT1"/>
    <dbReference type="OrthoDB" id="2576477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="211" mass="22754" checksum="C77E3D2D09BBDC64" modified="2018-06-20" version="1">MSDPLTDSPAIAPSTSALILSTTPPNDPPPPYPSRERRRTTRAGRRRRTTGMDSEHLQVSSTGNESDYDVASAAGTSPFPTGTDTEHEATENTPLLGSTSPRILSGGISGRQRTLSLTSTLQSATSFTPSFAQTVLSAFHPDRDCDLDSEADSDHEHSQHDFPGSRPAIEEQSRLFATELSNPQIGRRGAHPLGGPWRNASIYFPPNPFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVX2</accession>
    <name>A0A2R6NVX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v7672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000769">
        <property type="protein sequence ID" value="PSR77892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVX2"/>
    <dbReference type="STRING" id="98765.A0A2R6NVX2"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="71"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR77892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="327" mass="37009" checksum="B86A419BE55F4465" modified="2018-06-20" version="1">MESEDVKMTEDIPVNWPIANGKGKGKATEQTDGHDPENLPWVEKYRPVTLDDVVSHKDITGTIEKFIEKNRLPHLLFYGPPGTGKTSTILAVARRIYGASFRKQILELNASDDRGIDVVREQIKNFAETRTLFSQGFKLIILDEADMMTTAAQAALRRVIEQYTKNVRFCIICNYVNKIVPAIQSRCTRFRFSPLPMPEVEKRLNIVIETEGVKLTEDGRKALLKLSKGDMRRALNVLQACHAAYDNIGETEVYDCTGTPQPADIATIVNSMFSDEFTTSYQMISTLKMERGLALQDLLNGAYEYIEELEFKAHARIYLLDFIATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW33</accession>
    <name>A0A2R6NW33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl hydrolase family 95 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000762">
        <property type="protein sequence ID" value="PSR78034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW33"/>
    <dbReference type="STRING" id="98765.A0A2R6NW33"/>
    <dbReference type="OrthoDB" id="3206559at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.50">
        <property type="entry name" value="putative glycoside hydrolase family protein from bacillus halodurans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF3">
        <property type="entry name" value="ALPHA-FUCOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="1">
        <location>
            <begin position="87"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="209" mass="22763" checksum="F6ADEF21697E5C22" modified="2018-06-20" version="1">MAYKLFARASAIGPSANVTCSPEETGNATLIVTGATEAWITWVGDTEYDMDAGDVTHSFSFRKIISDSRLLGILNTASPSSASPSTYSSLLSAHINSYNSFLGSFSLSLGQTPDSSQSTDELKAAYQTDKGNPYLEWVLFNYGRYLLTGSAPGVLPANLQGKWASDTSNPWSADSNINIQMNYWFAEMTNMDLVTPLFDYIEVSAFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW78</accession>
    <name>A0A2R6NW78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Iron hydrogenase large subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v7554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000756">
        <property type="protein sequence ID" value="PSR78145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW78"/>
    <dbReference type="STRING" id="98765.A0A2R6NW78"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR78145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="482" mass="53657" checksum="F8D4E21252C0C470" modified="2018-06-20" version="1">MQSHTEVLNFLENNPEDICVSHKVPVLSIAPQCLASLAASISSSSTAAPVTLRQVLRRVEAFCKTVLGFKQVYDTTFARHIALLEHAKEFRERKAGVGQLPMLASACPGWVCYAEKTHAEMLPFISRTKSPQQVMGTLVKEWFGARWGKRQDFFNDVYSTRDIDCVITTGELDLMMRDKGWDLSKPVEGEDLEKDIGDTCHQNGDDIYLNDALPELVNHPGTSAGSYLHSLIANMVQNSPRPVDLDVKAMRSADYEEYTLTERESRTVIFRGAKCYGFRNLQNLVRKVGRDAGLQVGRGAAGKLAGLRGRGLKTRKGEVSAPEIYDYVEVMACPGGCINGGGQLRPPAITQNGGVDHEGFERDWQASGVQLDGEDIGRIQGQGAKWGDKEWTKKVELAYWQADQPHDSEDVQLPKVNGIKNKTTAVDHAALQILRDLCKPKDLAARSWLDSVDEEAETRRRKYFRTQYRAVESEVVGLAVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWL0</accession>
    <name>A0A2R6NWL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000763">
        <property type="protein sequence ID" value="PSR78015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWL0"/>
    <dbReference type="STRING" id="98765.A0A2R6NWL0"/>
    <dbReference type="OrthoDB" id="3267892at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="252" mass="28093" checksum="C5AC05D4AC941431" modified="2018-06-20" version="1">MFNQPAYKQRRTATSVFAGEHDTRPSWERDVLTTLLNGVPKYHAVEKAEEESERRAKKKEKKEREAVQKPAKALPKVVEKPLPVASSSSNAPVATKTVTKRAAPVPRVANNPSSFWQARPAIHISSVQRSVSVTPPPMPSSPPSTPGPSISSSTSRNSSKRLQTPFDDEDLAGRGRSRSRSRSVSTFSSIPRQMKQRKKRVAVRKGWKGWIEGSPKPSEKLINLDSVTVLRERTTRSGRNFDAIGEKKDFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWR3</accession>
    <name>A0A2R6NWR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v7333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWR3"/>
    <dbReference type="STRING" id="98765.A0A2R6NWR3"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR78586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="87" mass="9222" checksum="162883CD3A03A15F" modified="2018-06-20" version="1">MALVDALKAIALKKQITSAALCLAWVASLGPKVIPLPGSTNPERTAQNVAAGDIVLTAEERAEVWKIITGHEVKGGRYFTGSLHLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWR5</accession>
    <name>A0A2R6NWR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWR5"/>
    <dbReference type="STRING" id="98765.A0A2R6NWR5"/>
    <dbReference type="OrthoDB" id="2940229at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="595" mass="66246" checksum="C5ACD35FA57D9C09" modified="2018-06-20" version="1">MPKRSREACDTPSSSSTSPPTKRAHVLAASSPGPRRPSSRFHTPSSFYSLKVPLTVPSDSPTNPFGLKRSLFAYDLPFPLSFRKHLALRFQLLNSEDNLKGARSGDRKEREGVYRVVQVPRNYTFRHLHKLILFLFAADLEINQHKVSPSVSSEIPSKSTARRKTPRNASATSTQASKGKGKGRARTSSPAATTWDGHYFETLKDVIIQRDSVRPGTIRPGAKVWRKLSSVRERRLFRDLFNVPLSAAEASSSAGTRPSFLDDEDDSEGENAGWQWEAEDDMTAGHVWPKGPTLDKAFIYHHSPTVSVHVTANTLPIVTRVGTGNTPFVFAAQGSAGSLIKVAHVTMDEHGNERGLSASDLEDRSMPTPELVPETTVAKWNEPDAFKDFLNAEADRERPLRRSISPFPELDDASSSYAHSDRLPSSSPGDSTTFPSSDDNDNDPTTIAAATTTSEPNFSAASSEIDVDLSAYSDSVLFPFAFSAITPYPAHPLRRRRVERAQRRLSTLTRSRLENAVSDEEEEAKKAKAGERERRERRDRARRRAPDWARMEKALKKRIAEFKDWTEHAKNEDGDGEDEYEDDWGPDPFGDEAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWS4</accession>
    <name>A0A2R6NWS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWS4"/>
    <dbReference type="OrthoDB" id="2799342at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="16051" checksum="81EA6D0FD301E2AC" modified="2018-06-20" version="1">MQDEEALSKALIAEILQEDLRLLVDARKVEEVQSNQVSPPSALADGERPAEVNRPSSLTPDIEIALAFAVAEAQAASDVAYAKSLQCSYDASGFLNQQRALKLLAAEKKFRIDVEFAKKLGEMIQSGTDTRLCDAERYFFFFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWS6</accession>
    <name>A0A2R6NWS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000733">
        <property type="protein sequence ID" value="PSR78572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWS6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="6776" checksum="17D1039826E82731" modified="2018-06-20" version="1">MGAAAPALSSDLFAPRVRPNGHCQPKIGLWNPWVICHFEKKHLPPSALSGVPEHGTPARSDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWW9</accession>
    <name>A0A2R6NWW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000732">
        <property type="protein sequence ID" value="PSR78657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWW9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="74" mass="8027" checksum="218D1EF31E960E4D" modified="2018-06-20" version="1">MTRPGAGSNQELGAPLYATLLYPTLGARVIRTLPYPILAGLAFLYLPVGFAPALRPDQPQSTVSSKSRRIERMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NX59</accession>
    <name>A0A2R6NX59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v7270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000722">
        <property type="protein sequence ID" value="PSR78833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NX59"/>
    <dbReference type="OrthoDB" id="3058553at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR78833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="254" mass="28816" checksum="B2F1CA49B8314B6A" modified="2018-06-20" version="1">MNPYLTVTARYIDGSVEHPDSWKLHSKVIGYTIIHGDHSGANIAAVILKVLDCYGPGEKRRGQCFEHIVHLAGKAFIEALGALKDDDKDEDEEWLDPLDLDEEEEVDEPVDFDPADLLGKVLALINQVNKAAVNKFTLLAYDSPKVLNLWKKNYSDYVICRPEWEVLDLIHEVLEEVHEAHQSFSPEPFPTVWCTIPTLECLQRQWEIMADTPKFAPVHTAIKAGLAKLQKWYLAIGQTDIYYICLGMSCGFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXS0</accession>
    <name>A0A2R6NXS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v7022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000694">
        <property type="protein sequence ID" value="PSR79497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXS0"/>
    <dbReference type="STRING" id="98765.A0A2R6NXS0"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR79497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="141" mass="15584" checksum="A81AF4B50172EEF2" modified="2018-06-20" version="1">MSVGGRYVGMFLMASGYAGFALTLVWVSNAIPRPPSKRSASIGIVNGFGNLGNLIGSYAWKAEWGPNYHPSMLIGIASLALSSVLALVIRYLIIEENKKLQQDEIGHMTSAERERIEEAARLEGLTFEDALQRKKGFRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXU0</accession>
    <name>A0A2R6NXU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lanosterol 14-alpha-demethylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v7207</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000712">
        <property type="protein sequence ID" value="PSR79020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXU0"/>
    <dbReference type="STRING" id="98765.A0A2R6NXU0"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR79020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="62203" checksum="9F6EFF5D845A0233" modified="2018-06-20" version="1">MSTVAQPIEGYIGQLLTYFSSLPTSRLILLLIVNIPIITVAFNVLSQLLFRDKSQPPVVFHFMPWVGSAAAYGQDPIKFFFDCRQKHGDVFTFVLLGRRVTVALGPGGNNFIMGGKHTVFSAEDIYTHITTPIFGKDVVYDCPNEVLMEQKKFVKFGLSTDNFRAYVGMIEEEVLGYMKSDSRFRIFQMNDINEWGSFDALKTMSEVTILTASRTLQGIEVRNHITKDYAQVYSDLDGGFTPLHFMFTNLPLESYRKRDAAHKKISDFYISIIRQRRENPGQEEEHDMIASLMNQKYRNGRALKDHEIAHIMIALLMAGQHTSSSTGSWSLLHIADRPDVADALFEEQVKHFRQPDGTWRTMEYEEIKDLPILDSVIRETLRIHPPIHSIMRAVREDIVVPRTLSAPSEDGQYIIPKGHVVMSSGAVSQVDPILWKNATEWDPSRWSDPEGVAAQAYKQYDDANGAKVDFGFGLVSKGTDSPYQPFGAGRHRCIGEQFAYLQLGTVITTVIRQVEMKLASGVPDPNYQTMITLPKKPRDILYRRRQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYH3</accession>
    <name>A0A2R6NYH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYH3"/>
    <dbReference type="STRING" id="98765.A0A2R6NYH3"/>
    <dbReference type="OrthoDB" id="2507743at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="418" mass="45762" checksum="95F08DA211297A42" modified="2018-06-20" version="1">MPFPFSFKFSVPGVANPFTASTTHPAPGLSESVDGMHASVKTDRNLRRPPSSSSSLAPPQPLSRKRGWVPSSSEISIPQAVSASTNGYLDTPAKYRDMAHRSQEDEVEEMVADLPPPKRRKTLAGSIVSTAVSAALIGTAVGLTVYRLWRNRGKNPETLPPPPYEQGEWVPPSDSSHSSTARATPSTPHLKSKKQNRHTTHKRVIPRRKAPRAQPPVVAPHAPAAVPPSLLPSVAPEFQFGVPEPTQLEEENVDMDDQMDWMGDQLAKLIEQGKRALGSEIVVMSEAKEDAVDNGLGDWVEEDNNRMSASTSGSLRSRRRMRPSNIGIHSPPPTYASPKTTPITKSFNIHSRESSSTPLSVPNSPKRSGRRMSVSSGHSFVSQTIREDEATLEPELREAMERARQTYLQRKQQASETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYL3</accession>
    <name>A0A2R6NYL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v6730</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000653">
        <property type="protein sequence ID" value="PSR80473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYL3"/>
    <dbReference type="STRING" id="98765.A0A2R6NYL3"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="15">
        <location>
            <begin position="181"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR80473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="320" mass="35381" checksum="BAC67FDB52B8EED1" modified="2018-06-20" version="1" fragment="single">RPIRPLRSFATVVNSPTTQLTTLSNGLTVATEAHPHAETATVVFWIAASSRAETDKTNGTAQFLEHMAFKGTNKRSQHALELEVENLGAHLNAYTSREQIVYYAKSFRKDVGQTVDIISDILQNSKLENSAIERERDVILREQQEVDKQMEEVVFDHLHAVAFQGQPLGRTILGPKQNILSINRNDLDSYIKTNYTADRMVLVGTGGVDHNELVKHAEKHFSSLPVSANPIPLGRLAHPKTQFIGSEVRIRDDTSPTAHIAIAVEGVGWSSPDYYPMLVMQSIMGNWDRSLGAASLMSSQLSHIISSNNLANSFMSFSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYY9</accession>
    <name>A0A2R6NYY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000635">
        <property type="protein sequence ID" value="PSR80886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYY9"/>
    <dbReference type="STRING" id="98765.A0A2R6NYY9"/>
    <dbReference type="OrthoDB" id="2506773at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR80886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18438" checksum="F98251FDA50E47CE" modified="2018-06-20" version="1">MAKLTNEMPLSSPEPLDLSWWGDASTSFGIGVVMGSFWGVWRWAPGTMVGPKKEFDIGWAEAVAVELGMHMAIHHSLIASRPLHQNSILVRSDNSGVTTVINKGRSRSRNTNIILKNIYKLCAEHRVHLVAEHVAGKSNISDALSRGDVHTIKKQYGCEGLPKLEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZF9</accession>
    <name>A0A2R6NZF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000623">
        <property type="protein sequence ID" value="PSR81268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZF9"/>
    <dbReference type="STRING" id="98765.A0A2R6NZF9"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="95" mass="10079" checksum="5A775E5F36158583" modified="2018-06-20" version="1">MPSSRTMAGTSTGTNCDATVNNNAGCGVKAAPTNSYGPAFNSAGGGWYAMERTDTFIKVWFWSRSSGNVPSDVKNGETTIDTDNWGFSFGFMFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZW8</accession>
    <name>A0A2R6NZW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZW8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="69" mass="7937" checksum="81D017797C0A906D" modified="2018-06-20" version="1">MRRKMDNRGRLLAQDDSSITFARECLTLLRSESEAAIKGYIEGIPTFGRRPTFRYEDLVNTLKACIPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P018</accession>
    <name>A0A2R6P018_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000605">
        <property type="protein sequence ID" value="PSR81865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P018"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="89" mass="9560" checksum="CC786971727E15A8" modified="2018-06-20" version="1">MARPAYRIPLTSWGQVCGDGTLRSRSLVSKEIVDSVLNHSAQGQPRTRSAQPAAVGNGGKRVTKSTPHSRTTLNRISFPGSAPMFFLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P051</accession>
    <name>A0A2R6P051_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v6223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000604">
        <property type="protein sequence ID" value="PSR81928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P051"/>
    <dbReference type="STRING" id="98765.A0A2R6P051"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="46"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR81928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="159" mass="17923" checksum="4ABA529ECB5731F3" modified="2018-06-20" version="1">MSLSYFFSEPFYTLTDFDRLFDEAFTDRSHQGNQVPRRSGSESGPTLLRPRVDRMDVHEDARLNILTATFELPGIQKEDINIDVHDNVLKVSGESKISSERDEGGYAVRERRYGKFSRSISLPQGTKSEDIKASLENGILTVSFTKTSSEQAPKKITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0D5</accession>
    <name>A0A2R6P0D5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000593">
        <property type="protein sequence ID" value="PSR82260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0D5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5506" checksum="378F2AE076861A64" modified="2018-06-20" version="1">MKACTKSLPGWASRSYINAYAFQAALRLWLKPSVIFSLSSMCVIGSVTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0D7</accession>
    <name>A0A2R6P0D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000593">
        <property type="protein sequence ID" value="PSR82261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0D7"/>
    <dbReference type="OrthoDB" id="3268663at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR82261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="429" mass="49111" checksum="B327BD750E52EE00" modified="2018-06-20" version="1">MHSDSPSPTPPTRKRRRRAVQNEDHNIDPDRGSADNISPPHPEPAVAQEQSSDRNRPVIVGINREELYEIKRKTEYLRNIIENLKATNHTACQEIEALTQENANLLHTNRRLLESSTSGNDDEHEEQEDGPPSKKSKTSPSNKIFKMYLRLGKQFSACQIMWLSPEIWDFLYTSGNTPEDEDEESYNQRTRMEAISAQLMEFLPDVLHEQLNEDLFRDRFSHGMRAIRARFVADLVQSHAMVFGILDTAFLIKEERRELPAVKELIADDTFLYKPGTDELNGLLRHPSLKKALLLLLWGPSTLNCGDTITRPKTKRTNGRLWGLEATTDALLAFGATAIYFVLSCEAEFGEVGPGGTNFQEFYEERITDLTDLHAKFPNRYKKLMKYYNNDLFHNYDNQDASAVQNERQGKLALAMEMEVDDEDSSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0M1</accession>
    <name>A0A2R6P0M1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v6023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0M1"/>
    <dbReference type="STRING" id="98765.A0A2R6P0M1"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="41"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR82590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="229" mass="25550" checksum="F4292F28A52CF4F0" modified="2018-06-20" version="1">MAKTKKADISDDSEVEEVPKNKRAAADESEEADSGAESEEYEIEAILDAKHGSFAGGKMGYLVKWKNYTEEHNSWVNEDDAANAQNLIDIYWKRRSKAKKAARKSETKSITSSARKRKSSPAVSEAESVPAAKKRGRPSKAKSERAVSDEDDQALEVPKKGRGSLPARKGTSTAKKNTKPASDAMDEDEPEDYVDMSKNKNIATWEHLVDHIDTVERTEEGKLWVYFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0X2</accession>
    <name>A0A2R6P0X2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0X2"/>
    <dbReference type="STRING" id="98765.A0A2R6P0X2"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR82954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="202" mass="22035" checksum="F1FCE2C3618880EA" modified="2018-06-20" version="1">MAISLAFQCETCGRRFSVASNLNRHAKRCTTRPESATTARNPSDPQSTAGDKQPAINTPAPADTLAPSQATFTATLQPLLPATRGRKRSAPVGDSDAMPQPSTSNSDHPRRKRQRRAPSPSRWVPESLKNYDLTPYPKSTPVPLPPVQPYGHERSPLWEERNSFDEVSSSTPYHPTGWRGILPGPALLGQEIGTMGGRLLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0Y5</accession>
    <name>A0A2R6P0Y5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000567">
        <property type="protein sequence ID" value="PSR82966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0Y5"/>
    <dbReference type="OrthoDB" id="2769307at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR82966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="111" mass="12156" checksum="03D9A6FDD81AC99F" modified="2018-06-20" version="1">MRFLQSSTIIPALFASYAFAGPLEKRLTVTDIDTIVAPADGSSITPGTPFTFQYQVDNWCEAGYTPLSVWLVANEPTGSDVNSTAQISDSLYYFGNWLIPNFGWSAIPSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2V4</accession>
    <name>A0A2R6P2V4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000540">
        <property type="protein sequence ID" value="PSR84229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2V4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015312821" evidence="2">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR84229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="10081" checksum="CF7E8F72E3619C95" modified="2018-06-20" version="1">MVLVLGTLYVILRLPKVETLTVFPSDRTARYRTFIRPIALRLLNASNPVKNHNARIPHSIFRDCSSGGKKHGSRLADDGLEPEWDPNAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5I3</accession>
    <name>A0A2R6P5I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000523">
        <property type="protein sequence ID" value="PSR85847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5I3"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR85847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="182" mass="19714" checksum="AC8F77241539731B" modified="2018-06-20" version="1">MQSLNAEAGPSRIHSKEWAVTGLLTPAMSMESAKRPSQEVAAVSENGAVVSSATSKERLQHKGKDKAIARGTPHLTGPTSHSTSHEPTRPPTKRRKLSLTQSHSSEVSSLVYSPDRDTRPDYGETEGTAIEEIPSFELLDLSEVLALPWMEMKIDDSVSSQDIPSPAIFVPPGVHHLLESNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8V9</accession>
    <name>A0A2R6P8V9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000515">
        <property type="protein sequence ID" value="PSR87280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8V9"/>
    <dbReference type="STRING" id="98765.A0A2R6P8V9"/>
    <dbReference type="OrthoDB" id="1111611at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR87280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="416" mass="47108" checksum="CDF17A6E6D151CB8" modified="2018-06-20" version="1">MDLWGPSPVRAPGGFQYTFTILDEATGWLHEPKMRTKDKAFGRFVAWQSQCFTQNGIRIKMVHSDRGGEFLSKDFTNFIEKEGIVCRLTVHNTPEHNGMTERVHRTIFNTVQTLLAESGLPPFLWGEAHNHSPRSFLQFKTPFKARHGVRPNCTFLRPWGTHVLVKMDATSKLAACAKEGRYVGHDFMSNGVRVYWPERHSVTVERTVIYLTDDIVAGEPSPEELQNFNLPPVDDDNDDMPDLIPFDDPIDDRSPKLTPQSDQGPTETHNDNQTDESPPISPISKFNQLQPQRKKSPSAKVRTLTDGTGITGEEFDHANNFLSANIVYATSQVGNNPANMKEALARPDSQQWMLAMVEEITRLEARNSWEYVFPPTNANLISARFVYNLKGDEHGNPTRYHARLVTQGYKQVEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P968</accession>
    <name>A0A2R6P968_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000517">
        <property type="protein sequence ID" value="PSR87143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P968"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR87143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="61" mass="6778" checksum="2EC87990FDF0D40E" modified="2018-06-20" version="1">MSATNDSNTLDNLIAQNAAWAEANATSLPNPQSPKVRTERSMHMLGEFTPMHHLDSVDWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PG02</accession>
    <name>A0A2R6PG02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000495">
        <property type="protein sequence ID" value="PSR90492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PG02"/>
    <dbReference type="OrthoDB" id="2795339at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR90492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="145" mass="17176" checksum="80058C1ED4CB1981" modified="2018-06-20" version="1">MQPPVYLYGWEIDRNKLLRYAKRNNLREYVEELRWSEDEENEDEDIEPEIVIVHDRPLTIINVLFTLAKEAGVQPRYKCPLGSVFAHGTMVPFFALYSNYQLADAPPKTEIIALQNHLRARIGETEPPKWLPDDDEFRWRPLYCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PMU2</accession>
    <name>A0A2R6PMU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v4621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PMU2"/>
    <dbReference type="STRING" id="98765.A0A2R6PMU2"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="115"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="179"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="248"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="308"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="365"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="428"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="491"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR93726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="546" mass="58395" checksum="197E25379704BD9F" modified="2018-06-20" version="1">MPPRRSTRAASVKPQPVKPEVKKPAAKAPARARTATKRPAPPEDESRTPSPTPPTKRRRAGSRAAATRAEAPEPKAKPAPKKPIERKKVEKVEKEQKPYFNPLPAPPEHLRPAPQLFAWGAGNFGQFGMGEDSLGELEKPQRNKLVETKMQEGVYGEEGAGLEAVAAGGMYSLFVDEKGTIWSCGTNDDAALGRITSNIPNPDKEGEFLDIDTLTSQPFPLQSLVDQNFRAVRIAAGDSISAAISSQGDLRVWGSFRGVEGLLGFSSGQKHQFLPVPILDLPSKPGDAEKFTAVAAGNNHLVVLTTHGHVYTWGAGEQGQLGRKVLERRKIHGTTPEKIVLGGRSHKAVVIGAGNYTSFAVDEKGDVWAWGLNNMGQTGTGFTSAASDSEVQLPKKVIGLSKKELGDDETVVQIAGGEHHTLFLTSTGKVYACGRSNGGQVGIDEDDPVVKDREFPDMLEKPTLVTFPDMDDPIVHISAGIHNNLAVTQGGALYTWGTGPQSELGAGDETELWTPKMIVRKDGGSWAATAGSCGGQHTLALLRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PN17</accession>
    <name>A0A2R6PN17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PHLCEN_2v4691</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PN17"/>
    <dbReference type="STRING" id="98765.A0A2R6PN17"/>
    <dbReference type="OrthoDB" id="3361414at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="196"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="742"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR93796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="854" mass="93311" checksum="ADA99004FFE7539F" modified="2018-06-20" version="1">MPAAFKTPVQKGVKPSKKTRVVKRRGRVNNGLESDEEIEREARTDSDTDEDSSLASESDSETASDDENHAGIVTPSTTQSPPPLDITGPSSSLKAANLANGTAGPFVSTTDWAQLVADENANGASDLPVIDFADMHTHVIPEPQPAAARPRKAQKQSRKKSTPHVPQEPPSETKPEVEELPPPVADEPVASTSRAASTDPDAFRPRGQTARQAYQQRLQVDPAFVPRVGEFWGHDDRLLDKDLRSLSPWWRGRWQTRGRGRGGFSMRGRGGRPFPPGTHAHEEEQKETEVAQEEIPAIDRAWTHDGFEEMKRREEVRREEQRRFEAQQQFAHQPAASQRGSAFRGRGGPFMRGRGSISRGGALPHVSPRSMPAQDTTINRPWFAMKPEKVWTKQSETFLYMEPVLRARPGQGPGLRVKLPGRDGQVIRGKKQTHYSTFSIPFQDHTTVTSTAALSDLGERQFIVRFPCPLAAKETITREVPSVAEAAPQEAATFAGTELSIEEVFTIRPHAVPNHVPLVPPPTTDVAPQPSSSQPVSSPSSPITELPASNKDGEAAFSGSEASWLLEQVGMGGSIGADSATSPSAEIQASVLRTPQTAEVFAPVPQAPAAVDESRPVPPVLHPLQTTFSPIPPTSPPYGSPYSFGPTLPPGIAMSHQGFPYDVATGQAVYLQPTPPPMFTPRPMMHGYMGHPSTSLPFVPGHMHHPSQEYVPQIQTPPVSGFIDPATGVPIFAPARQNSRIEIRAPSEYGGKSLKHVPRPSGLRTTTSEADSAEPEPTADTTSESWQQQQQQHQPHPVSPPMMAYVPYPQQYYYPDPNGYPPYMDMSQPVMQYEVYPPHDQHPTITIGSTKQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNL1</accession>
    <name>A0A2R6PNL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000463">
        <property type="protein sequence ID" value="PSR94104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNL1"/>
    <dbReference type="STRING" id="98765.A0A2R6PNL1"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR94104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="256" mass="29193" checksum="B005A7AEE59AC12A" modified="2018-06-20" version="1">MARAQTFTKVDLTPKKHHGYSVLLFIFGTLFPPLGHAHNFYIQNVRNNKNNRRTPKWIQKYGLVDTSEIKRKERKSQWAGRYNERLPHSVLEEQPYEEGQDASSSVDVSVENEEARRGELWNPNEEQYYGQNGDRSSASIRTNGSGGRWRYPANFEDAVAEPSRKKSSKKKKEKKDRWARTEDAYSIGESGSTSRRKKSKKRKSTADPSTYSHQSDSTTDFPEDAEGGLYGDTRPAPEPAAVNGRGDADQIFTHEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PYV6</accession>
    <name>A0A2R6PYV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v4238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000429">
        <property type="protein sequence ID" value="PSR98918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PYV6"/>
    <dbReference type="STRING" id="98765.A0A2R6PYV6"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR98918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="485" mass="53943" checksum="B369B79A2C285A9A" modified="2018-06-20" version="1">MSPAPAAWAADFLQQTPVHNPLKEAFFNGEQHSQQRGNNQIHSSLAGVSQQGSVAWQPSVLGFPSRMASMPMQAYPMLDPGQQASTEVDASQWDEAFQSHEGLLHSEAAVSDPMQDTSRPLNDADELARAAASVIDAVQYERNPKFQNSQFLGLMKQLRDREMVVEGDTMVPVEEASSTSGGWATELQKSATDVKGKGRALEPLRMTVNESDIYSIGAQNRPTEFDLSGRSEVFGPAEEEIDAYFRTDNDDYINYWRGPESQGARFQSSTTPPAVLAEWDKLQRDWDIFEATATGIKPISNYQFQANNPYVLGEASRHHNMHSTLSAASLELQSVLELEAAVQRDPYNATAWFSLGVKQQENEREQKALHALRRALELDSTHLPAWLALAISHTNDGNRRGSYEAIRSWVQHNVRYREAVEAYRASHGDMEDFNMAQTGNSDSLVECLIAMARSDISGEIDADIQIALAILMNTNEVSFYLHGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q2B2</accession>
    <name>A0A2R6Q2B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v4106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000405">
        <property type="protein sequence ID" value="PSS00879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q2B2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS00879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="56" mass="5934" checksum="D7886F153C836EB3" modified="2018-06-20" version="1">MGWRRHSMGEAAGKDRQTSMIGGGVIGMQEVTEESMEESGAVTVDEETMKAGRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBD2</accession>
    <name>A0A2R6QBD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000373">
        <property type="protein sequence ID" value="PSS05425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBD2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS05425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6405" checksum="F6F613C7056A7189" modified="2018-06-20" version="1">MPLAASRSVERRIHSIFGANVATVYSCLEGCNPICITSSRSDLLQAEEVRELVAGKHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QBG9</accession>
    <name>A0A2R6QBG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000368">
        <property type="protein sequence ID" value="PSS05483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QBG9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015327446" evidence="1">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS05483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="64" mass="7479" checksum="08384B54C7581248" modified="2018-06-20" version="1">MILWSSFDFWLQLVTLAEEASPADWNDVATDASYDFATTLQRQVWAELPGFVIIKQSFLRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEF4</accession>
    <name>A0A2R6QEF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PHLCEN_2v3691</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="MLYV02000363">
        <property type="protein sequence ID" value="PSS06524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6QEF4"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="904"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="516"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="663"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="759"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="222"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PSS06524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1443" mass="160163" checksum="50E226C71D98474B" modified="2018-06-20" version="1">MNSLYTLGVRQTNSIQADLERLRNGDTSAALLGQISASLAAMGRTVDDYDSMAKREIIKAKQEKAMMRVQKFRSDYAELRTQFEKIKGERETASRSELFSASSSSTVPLSPAHGDSRRRFLTGQQPSSEVSESPFRGPTPLPQSSLREDYALREHSFIHNTDARLDDFLAQGRAVLDDLVDQRTVLKGTQKRLLDAANTLGLSRDVIGWIERRRLRSPSEWVDMVSDSSSSQNHDYTEGASAVDIQDVLNSNRRSRRDSQYGEGGYMFDGPGHTVNPSSVSRMTLSEHGRRSSEGRSRGSQSRRRSEDRGRDTSSSRSLRASRDSLPSLARSEDEYTDPGHEVEDEGDHATLRRSRRKSTTSPQRQSVFGNIASMFGRAVPTTESPPRSRRPSLSSRSSRTGLLRRTSSRRSDAGSDYAIESDDEDERWGYASEEEDDSESDITDDHRQGDSDSVDFHSIEEDSYPPSPGLALHTMTGPGDPIFGDEARIDMGELDLHDPPPPGPPSRQTIYITDEDVHIRFIGFETVTIRHFLWRMACVLTFGILGLLGHWFPRLWLRWVAKEKAFKDMEHGFVVIETAYRDIALFPVRKLHYPYHITTVFPAQVDTLSRPPSRTNGDANIGILEHLLVVDYRYARFALDPRTGLFNIVRNWRDPSWTGIQSVSNGLTQSEEEQRLALFGPNVIDIEGKSTVSLLIDEVIHPFYVFQIASIVLWSLDDYYYYAFCIALISAISITTTLIETKKTISRMREMSRFSCPVNVFTDGIWKRRESTDLVPGDIVNLMDPPLAVFPADIFLLSGDTIVNESMLTGESVPVSKVPIRDEDIALWKEAIDVSSDVSKSFLYAGTRVIRVRGALTADGSSGAPALGLVVRTGFNTTKGALVRSMLFPKPIGFKFYRDSIRFILVLAGLAGLGFCASAVQFVRLGIKWHTIMLRALDLITVVVPPALPATLSIGTSFAIGRLRKLGIFCISPSRVNVGGRVNVCCFDKTGTLTEDGLDILGVRALERNAHRFGELIEDVHDLPSSRDKANFLHALATCHSLKMVDGNIIGDPLDVKMFDFTKWTLEEGHVAGTGVVKSRIGGARPAALVQTVVRPPGTAQFRVEDALRGSSKHAHFLELGVIRTFEFVSALRRMSVIVKRLKSSSMEIYVKGAPEVMGEICEPDSFPDDYDDLLSYYTKRGYRVIAMAGKSLEGLSWLKAQKMKREHAESGLKFLGLIIFENKLKPGTTPAIQSLRAAHLMCRMITGDNPLTAVSVARECGLVNQAAHIFSPVFVRGNSATPMSKLEWSCTDEPAWKLDDYSLKPLSPPAHHTVESDNVDVHDYTLVVTGDVFRWIINHAALETVQRMLVKAQIFARMSPDEKNEVVERLQGLGYTVLMCGDGANDCAALKAADVGLSLSEAEASVAAPFTSRTPDISCVIEVIKEGRAALVTSFSCFKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEM7</accession>
    <name>A0A2R6QEM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v3693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000363">
        <property type="protein sequence ID" value="PSS06526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEM7"/>
    <dbReference type="STRING" id="98765.A0A2R6QEM7"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS06526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27807" checksum="558D6089D1353562" modified="2018-06-20" version="1">MATSNLAILTNSHKIIALKKRAKRDQVKEVLFDEGARREFLTGFHKRKVQKHEAAKKKAIEREKQERLDNRREKRQLLAERAVENAAEVEKAYGGQVEEDDSEDEWAGIGGSSKKGKERAEEKEEEYEDEEQLATVTVVEDFDPEALLHGPDIPRNVEEETSLSTLPPTTSRTQKTRSSQERNGGIPTAMKKIRGKASTKPKDIKYQTKSDRKSERSKQQKRRTEKAQLAGGKASRKKIGGRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QER4</accession>
    <name>A0A2R6QER4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000360">
        <property type="protein sequence ID" value="PSS06601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QER4"/>
    <dbReference type="OrthoDB" id="2987506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="357" mass="38582" checksum="BDE885E7DAE3B03F" modified="2018-06-20" version="1">MSTYNLNISINPDDIPLLQKAGYRLCIAKRVNARYTVVWWSGGAFTASNSVTWDAEFQVFGASKFQKGLQVEPVTNPSEIKSGQTVVLDSNGVMHPATGLPDKSGAFRVQLDYPISIGVNAKLRGAWSPISLSLQPFASGVVSLTPIEKVLVWFDTSSSTGIMFSDVIINSIELDFTSKTSQSVTYVSDPHRPGNGSSGSWIADGSAILSSTYNVETDTFSLETPSALLLGKLSAIINSQNSVPLTVTASVSFSQPAIAQAFVQYALRRRPDGVRTWAFGSTGPATVGSRLRAQDDMEDKAAIQFLQGAFLAVLSPFQINSNVRGLSFKVLDRNSHVLRGRRDLRAKPNPRYPLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QF00</accession>
    <name>A0A2R6QF00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000343">
        <property type="protein sequence ID" value="PSS07209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QF00"/>
    <dbReference type="STRING" id="98765.A0A2R6QF00"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015316751" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="152"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS07209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="220" mass="24026" checksum="538D5E9FF8036003" modified="2018-06-20" version="1">MSLHFAILSSVLAIGASAHPLENTKLPGQHVTAKLRQKRGSFAQVHNGSIIFDPTFVRIEMQTMLVKYSMASQFISGVGLNADTSPDVNYSSFDDTPISKHFQSNSKTLVPQLLSSRSDSETIIGLPGVDYADVHTMPMKDYIGSGNMDILYYGPLEFGSPPQTLTVSVDTGSADTWVPSHCPDCSNEQFDPASSSTYKDTGKKATVTYVRRNNLSLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM55</accession>
    <name>A0A2R6QM55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000324">
        <property type="protein sequence ID" value="PSS10984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM55"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS10984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="201" mass="22354" checksum="0EB77CA9FE4CE917" modified="2018-06-20" version="1">MTQEEYVLFPLYTPPPSSSTTTHEPASTYTRSKVSDNDHCFAPRFTADATEHAGIATDYKLSTNWESMVREQSSYCVDPGFSQYSVGMYDENLGEAENIDTSEGPSYPETAALFQLTGLAYEENKTDQFSPLEPGGYPVPGILYRAEPELPWLPMTVVSQPKQCPKRKYMTPLACFFCRKRKIQCGGPSQVCGLNESPSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QXP9</accession>
    <name>A0A2R6QXP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000292">
        <property type="protein sequence ID" value="PSS17145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QXP9"/>
    <dbReference type="STRING" id="98765.A0A2R6QXP9"/>
    <dbReference type="OrthoDB" id="3357985at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS17145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="299" mass="34085" checksum="A58DF363D8FE799A" modified="2018-06-20" version="1">MADSPEVLVAATFPFNKANSDVVLRTCDNVDLRVRKAILSEASVVFEDMWTLPQPPAQTGPDDGVPVVSVSENERTLHYLLRFCYPMENPNLKTVEDVFAVMEAARKYMMDHVLIEVKRQFLHYAEREPLRTYAIACNRGLEEEMRIAAKASLLEPLADSHEMEELERITAGAYLRLSAYHRACRKVASSLGYCGRDKTGRRVWAAKKDWRDSLVNIEPWWASYMILASEALKIRPRGTTVLKEEFVHKFLVDVIGPRDSQYEKNKALSEFAEFSAEFAEAVERIISSIQLKIPLKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLY2</accession>
    <name>A0A2R6RLY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000229">
        <property type="protein sequence ID" value="PSS30985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLY2"/>
    <dbReference type="STRING" id="98765.A0A2R6RLY2"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="97"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="457"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS30985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="74012" checksum="4CF293DCC870E71B" modified="2018-06-20" version="1">MSEEGHPPSAWEHTDNERPSYSPHHTYSNTPAQPYLTRDSLDVHPQVPPTPTRSASPPRSSAESPRRQTNLKWRDSTLPAATPISVQPPDDDGILETSFEENVLRALCDLDCGVPLLLDRIKQSMISCREVSGFLKKRAALEEEYGRNLQKLARSTANAYAGNGGRAGSFVNAWSGLMKMHESVAENRVRFATSLTEMSQELAKVANEGDQERKNTKDLAQRYERALQDAEATTEKSKSRVEVTAEELERVLIQKEGESVRDTGVQGRSPGGVSGKRVIGKAVAKGGLLLKGKNPGNIQRQADDIRARMSAASDAYRKNVTDTQAIRQEYFNFQLPRILRVLRDVAGNLDLGTQYHLNRFAMLFEATVLDEGCTLAPVDDKPGVKSIIESIDNRADFKVYMHNYAFAHGGTHTRGPRREGPKEDGFLPPIAAVHHAAGSPNTTNSQIPDKGRPTFGVDLAEQMARDDVDVPLIMVKCCEAIEKYGLDYQGIYRVGGTVTKVAKLKERLDKDLDSVNLDAEEWSSDISIVTSVLKQWLRELPNPLLTHQLYDSFLDATRNDNERLRHIRLHERVNDLPDPNYATLKYFMGHLHKIVEHEAENSMTVQNIAIVFGPTLFSPGQPGANGHMNGMADAGLQNKWLTSSPTQAIETILDHYTDIFVDEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVQ2</accession>
    <name>A0A2R6RVQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000158">
        <property type="protein sequence ID" value="PSS34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVQ2"/>
    <dbReference type="STRING" id="98765.A0A2R6RVQ2"/>
    <dbReference type="OrthoDB" id="2786161at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="10463" checksum="47CD830E1A81550B" modified="2018-06-20" version="1">MAKNPKAVLDAARKGSLHEMSILANAWSATPGLIAPAAALDVFLTHLMERKVPGSLADKFSDSANLVFSSMLGITQMGIENDDVLAKRLVLAWPGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RVX2</accession>
    <name>A0A2R6RVX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v1795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000146">
        <property type="protein sequence ID" value="PSS34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RVX2"/>
    <dbReference type="STRING" id="98765.A0A2R6RVX2"/>
    <dbReference type="OrthoDB" id="2801521at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22224" checksum="F81FC01ADF5F19FD" modified="2018-06-20" version="1">MFISILASVSVAVLLAALWKVLPNVIKSLFSPLRALPGPPSDSLFFGNLNAINNAENSVLHEEWLEKYGDTIAYSGLFNIRRLFTVDTRALNHVLTHSMDYQRSEEGRYHLARVVGPGVLVTEGEQHRRQRRVMNPAFGPAQIRDLTEIFVEKSVRLRDVWAAELAKTSGPLRIDVLSWLNRATLDIIGLAGTSPCVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S005</accession>
    <name>A0A2R6S005_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000111">
        <property type="protein sequence ID" value="PSS35613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S005"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="59" mass="6518" checksum="34C180BEC5B16B35" modified="2018-06-20" version="1">MTARSRVCDVSIGLAPGLPVEHLRVKRESDSPITLGHSEFIRVGMTIQFPKTFGGTRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3D3</accession>
    <name>A0A2R6S3D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3D3"/>
    <dbReference type="OrthoDB" id="3168445at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS36773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="712" mass="77088" checksum="9240426E09A9167C" modified="2018-06-20" version="1" fragment="single">RSSRLRAGLTFFASRKSLTPVRTGSVARQRSLQRALSKPIQQRPPLDRSAGGQPFQDELHKEFEFAPSESTPNAHNLTRQQNPATTSSQSYYNEERNLLSRQQILPIMPQTKDTPLPAIPTSAPKDGLFKRLTTKIRSTHPSSARPPASSPSVLAAVSKPRRKTTLKLPSLPRPQHPASTSANAFISAEHREAALRARGLVPARYRDRHGNTIPLSEQESQMDQRFSVLVEEREDHEDSEAKKIREAWLRRNAEGEASACEDELAREDLPPVIETALSPRKPKVVREHTPPPLSPSRAEFTTTEAMHLDNVFGMEPTDVPLPESPAGPGSIRSGRSKAVGSPIEADERVSRWLLSTPTASPSKGSTSSRSGNENAAEEDASSLLATPSGKGRKDRPVHISILSVQSSSAPSSPRSQKSVLPPLPNSPPLESEDPRSPRTASVPTLSVSPATPSPHRGRSAATIPIPMTPALSPTRTASSSFTSESPLTPTTLSAPSSTSHAHRMRKSSMTSGESHSSEGPSRHSYVEDQKTRKMEAVDESGVLLMSNVATVILESPVEDEPVADIPTSPLATPLPRTPRPGDREETGRKKSGLFGKRAADEPRPPPLSRSAHTASSMTNLRRSVTGTISNKLHLRPKSTLVVDTRVANDEQSSLGSPISSTRTMASSTSLPIARPRQALSPTMHSRGSILLQAKAVEDDESRRLSELAFLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5G2</accession>
    <name>A0A2R6S5G2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000042">
        <property type="protein sequence ID" value="PSS37493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5G2"/>
    <dbReference type="STRING" id="98765.A0A2R6S5G2"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS37493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="295" mass="32024" checksum="FDDE1290EE2B8427" modified="2018-06-20" version="1">MPEHEGKTLKQQIPKQQQHLPGLQKDMEPEPFDTSLESASGPRPYQGIGKLRGKKALITGGDSGIGRAVAILYAREGADVTIVHLPQEQTDANDTIAAIKREGQEGLSIAFDLENFKECKVVIDKHIEKFGKLDILVNNASKQTMEKDFSNINLDIVESSFKSNILQMFAITKFALPHMHKGASIINTTSVTTFKGSPSMVDYTSTKGAIVGFTRALAKQLTPKGIRVNAVAPGPVHTPLQPASRPAEQMEGFGEQSQLGRPGQPSEIAPSYVFLASAEAELYHGQILHPYPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5L1</accession>
    <name>A0A2R6S5L1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5L1"/>
    <dbReference type="STRING" id="98765.A0A2R6S5L1"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="149" mass="16926" checksum="F662F51853B9EEA5" modified="2018-06-20" version="1">MPMFNLVHNIGRELGDNKVLINAILTLTADSFFVSPRTRAHRTFHLLFDHLKELPKHVITEEAREWDYGEYEGLRPAEIKAKNPTWVIWNDGCPGGESAEEMRSRVDGVIEKVCEFRLEIVIVCAEARRSESITDCGLKRVKGRATSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5M4</accession>
    <name>A0A2R6S5M4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000035">
        <property type="protein sequence ID" value="PSS37555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5M4"/>
    <dbReference type="STRING" id="98765.A0A2R6S5M4"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS37555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="244" mass="26812" checksum="43708FC95EE8DFFC" modified="2018-06-20" version="1">MPKSTKKKKDKAADFSKAKLKLGKEKQTPNNAVDTSFKARSIALPSQTITHTKNDATPTTKRRLSFEDLVSHMKHYNSGTRKDAILGIRELFENHPEIVTPSLTVLFSNCIRIIGDEDASVRKGLLAFFGWLLPRVSIDDLAPHAPVLLLFTTSALTHIFPEIRIDAIRFIDLFLEFIPDLVVEGWSQASGGHGKRVLEGYLGILSAGTAYGEDGDTGPVKATSTASVVLSPKVRILMNKEILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6C0</accession>
    <name>A0A2R6S6C0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000029">
        <property type="protein sequence ID" value="PSS37837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6C0"/>
    <dbReference type="STRING" id="98765.A0A2R6S6C0"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="483" mass="51969" checksum="17994CFEEB5506D9" modified="2018-06-20" version="1">MPATFTRQFDTPAYKGKVTVNTGLFINATGTLITKISAASAKDVDIAVQAAHNAYKTSWGHKVPAYERGRLMNKLADLMEKHAEELSALEALDAGKQYFFAKAVDISATIQNFRYFAGWADKNHGKTIETSEAKFAYTRHEPIGVCGLIVPWNFPLLVASWKVAPALACGNAIILKPSEMTPLTALKVAELSVEAGFPPGVINVLPGYGSVAGQALTEHPKVGKISFTGSTLVGRKIMETAARTNLKRVTLELGGKSPSIIFDDADLDQAVKWASMGIFMHNGQVCAAGSRIFVQEGIYDAFIKAFATASKSLKLGHGFDPSITQGPCVSQTQMERVLGYIESGKQEGATLLSGGSRLGEEGYFIEPTIFTDVKSDMKIVREEIFGPVAVIAKFKDEAELIEMANDTVYGLASAVYTQNINRAIRVANALETGGVWVNQASLPDFQVPFGGVKQSGYGKEMGEYALESYTVVKAVQVNLGAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6N5</accession>
    <name>A0A2R6S6N5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6N5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="575" mass="64501" checksum="334662036AA38A93" modified="2018-06-20" version="1">MNTLPVDLLCAIFSRLVNDHKPDLASCSSVSWLWRQITLPQLFEKLCIRFVVQGGSDRGVLHTAEGEEGEKIMMHIDEGEGKLCILFDEKDDNDPDPPDWHRSTSRVVLPSFVAFLKRRPDIAASVRILVLTQEPEDEGEEIQTTNPETLFLIFNQLHSLCNLELIDIKVGETHQPDLELVVNRHLDRLSINLYRIRACSRYEIPATSIIRILSFFRSISSLPLLGVFVEDSEENSAGNDMVGFPLPLIKHLEIIDVCVLKPLVSVMQSRSLLRKLETLKMDNAEYVEEDLQPLENFIAQVSSTFLHFALPAYRCFYHVFGRHFTGIILLALTANGSLNWIILSFDDRYYGVRKRPFHEVVSCFDDIFPRLRKKGILKCVGLDEYRYTCLLGATASSLPRPDTPWPPTTMSHYTVSNTFPSSSLRAALAVSVVDGSFADTAYQLFSKRLANGKVGAPQTIYASSTVLKASGEHFRAQLDGGFSTHESIPEDTAAYGYESDSDIDDSEYLEKGLLTSFDEAEAKESDQAEETRTIVQKENMKAKEEGPNNTGVETTLTMVQSVKYTVVIPDVAAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE48</accession>
    <name>A0A2R6NE48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MLYV02001342">
        <property type="protein sequence ID" value="PSR70635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE48"/>
    <dbReference type="STRING" id="98765.A0A2R6NE48"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF452">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015216534" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="549" mass="60797" checksum="4E1D5C7C493C1D7E" modified="2018-06-20" version="1">MRISSLLPLLLAPAAWAVPASEFQNVLGELGDLTGLFNDLGEGAQQVTQRLKGTFDKSKEHAEQWVHEGKDFVRQNGLVYELVTHPLFSDYQLRVTDPKLCDPSVKQHSGYLDISDGKHLFFWFFESRKSPEKAPLTLWLNGGPGCSSVTGLLFELGPCSVTSEGKNTTVNPYSWNLHSNMIFLDQPVNVGYSYSDDGSTVNTSPVAAEDVYAFLELFLNRYPQYADAPFHLAAESYGGTYAPNIASVIYKNNKELALAPTPKIKKINLASVILANGITDPYTQMASVPTFACDGPYAVYDDPDGAQCTSLRSKVPTCQRLIKSCYDYNSRWTCVPAQAYCYSQLFGPLQQLGLNLYDVRKKCDRSKDGDLCYKQMDWIDTWMNDHKNKKALGVNPELDFASCNMEVNQAFFGQGDGMHNSAALLPDLINDDIKLLVYAGNADMMCNFIGNEAWVSKLEHKFHAEFEKSVSTPWITLGSGKIAGEVRSAGGDGFTAGNVTFVQIYEAGHMVPFDQPEAALDMFTRWITDVPLSLNFKDMAESAPFGGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NEL7</accession>
    <name>A0A2R6NEL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001336">
        <property type="protein sequence ID" value="PSR70678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NEL7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="68" mass="7755" checksum="177C44FD8D815CDF" modified="2018-06-20" version="1">MNPYWTPLTLAVQCWLIAVEKRAKDSNEFWGAKEESKTSCKGPLAERKVISGDARRVLSTGREWDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NES1</accession>
    <name>A0A2R6NES1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v13309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001312">
        <property type="protein sequence ID" value="PSR70811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NES1"/>
    <dbReference type="OrthoDB" id="3070253at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR70811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44141" checksum="622F11418F56DD67" modified="2018-06-20" version="1">MSDVPEAICIPSFPVELTDNIIDQLYTDKATLSSCTLVSRSWLSRSRHHLFAKVQVLGFKTHFPPFIEFLTQADGGPRINPPACILIKHLCLDGRESEFGSLGPLTTTMLKTLLSNLPNLLDLDICGVELKWIAPDTDPHDGQPDPVNLDSLTLDAFTPSSFTDPSDLVLSLCFFSSINLLRISSPVYATDIPEDPRVVAAHPSLVTTQPYFPSRLEISSIEVCDASVNRHYDEDTLSTMLLTAYNLPACTALTNLTLRMSTMSPLPLLDRRYRQHQSHNDMIFRAASVLAIYAPATLQTVTLDILFDGDYMHLNRLYSMVEDMAQGLLWLQSVITKHKGPKLCIRWNGLQESVRHEEEREEVEDELCPLRETEGLKLILPFHKFLSAFVNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFG3</accession>
    <name>A0A2R6NFG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v13055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001295">
        <property type="protein sequence ID" value="PSR71086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFG3"/>
    <dbReference type="STRING" id="98765.A0A2R6NFG3"/>
    <dbReference type="OrthoDB" id="3238632at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015352353" evidence="2">
        <location>
            <begin position="17"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="515" mass="55335" checksum="1BCD740E1901AAD9" modified="2018-06-20" version="1">MNALLLGLSLASAAAAQVANPMYMVPAESVYGGASSSNGYASSAQATPPPSGAYTAAASAYTAPPSSSDDSFYSVMPYSSYMAGGYQSLNCGYGYSKGSDGSCNPQSWVRNHFIFAEGSSYGSSCDSSNNYNYNTVTSTVTDTVTQTYTQTVPTTVTVTQTQTYVSTDIESFTQTQILTSTKLVPTTRVWVSTEIIDHTKTEEHTLTATETSTQINLYTRTQTETDTATQTVSETETDFMTQTIFSTILQPTTYVSVYVSTQVIDNTKTIEQTQTATITDTMTSIQTATVTDTMTDFMTVTQISTYIQPTTFISTYISTSINDQTETIENTLTATVTQDMTFTATQTYISTLTDHETSTATQTQTETDTLTDFMTVTQISTYVQPTTFTSIYVSTSIMDETLTMENTITQTMTEDMTFTQTQIYTSTVTSTATQTELETALATCLSNCKNTWNMSAGNSNSYNTYASMPMSSLNSYAATSTSSAYTAAATSTSSSSGYGYSGSSSSSSYNSGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NG30</accession>
    <name>A0A2R6NG30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001290">
        <property type="protein sequence ID" value="PSR71259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NG30"/>
    <dbReference type="OrthoDB" id="2803882at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="256" mass="27939" checksum="4CC0180EC236DF7B" modified="2018-06-20" version="1">MSQPSYDPEVVTIFQQQFVETYILNALTVMIAFSAMRIYALWDCNIPLALIVVILNLAPVVTNIYDFSIATPAYSLDPIFGAFCSLPIPSTRLFSFTYVIQPVWTEQIANRAGVDNVFEQLTPATLFFSTSARHIRPVDDIIDLFSNSSLTPILISRFLLNLRELRPSENGGESLGNFSQFSVSGFRVPSNILVGNLGGNLADDTGDENTTTDDSGEGRASSGSEGGSNDSSDVIPTEESRETVENALPIYSKSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGY0</accession>
    <name>A0A2R6NGY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001262">
        <property type="protein sequence ID" value="PSR71593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGY0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="49" mass="5380" checksum="6B2E0B5BFE9B675A" modified="2018-06-20" version="1" fragment="single">KQPSTACRQWPPWKMHAARPDCFKLLGSIAGGPSLLHEASDAHLVDFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH69</accession>
    <name>A0A2R6NH69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH69"/>
    <dbReference type="STRING" id="98765.A0A2R6NH69"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="578"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1094" mass="118940" checksum="5BF7B7D1EE599AE9" modified="2018-06-20" version="1">MASSTRSPSFISTPTTQPSSSSSSARKPSKKSSFLSLRREKKPADPLGISSPPEKVLSREDRSNRTSPSSFHGFESGNSSRPSISHPVSLNSHRSGYGYQSRATTADASGGRREKSRQTKPSFDDFGSSIGDSEYIPWPVNQEESPDIRRSATTGRSIKQSWEQQAFADQSPYYPFRDSGSSSLSQLETPPQTPIDEFSFYEPIFSMPDLVAAPIAGVETMDALVDGMNGVTVDHNIAGLGNVSSRSQFLKTGHHPLYHPPLPTPPPGVTLGRPLARKRNAKHDNYDSDIENDQSSPPGHLHRNWDKQHRRDSSRTASSSTVTRLSTLTTSTSSSILSLSSAEDRPRSTYSFSEDVIPDVINATPPQVKTVAPSISDIIRAHAPPSQQVRSRPTLSHKASYTSSQDHSIYHDALELPPDPLTSEEESDMVSRSSVDTIAEEVRQTLRNQSMSPMSSRPPSQHQSLPSGTRPQSTATDYTRSSGHRNSSLTSSSMISERPPLPAMDLSGLTKNSIHSPSQAIAQYLRSSRLTTVMKLTRAPYASRDSPLDVSFSDLGSTTGTPLVVFLGLGCVRHIMGLYDEMAECLGIRLITIDRWGLGRTGSPRSKLAKGIPDWAYVVEEILDRLHIDQCSVMAHSAGAPYALAFANRYPERIRGNICLLAPWVGGGEGAGYKWLKYVPNGILKTAQAAEWKVQAWMLGKPPTLAYEGIGFDVQASSPQSQSRVLHTLSGPTLPMTNPTISSVKEANPRPSMCSSAFSDYDDLHDFDGKFDSRSTLGRRSSGSQRNRTISESRPSAKTPTNRKPSRGFLGRFKGGTSTAPHSPQDDHPVASGPGKRLKALRSMGSLKGRSATAPAQPLKKASSTRTPSLTQSPGLDVGLGIGDFDWTSTMDTKSTSTRKSIKSEVVSSLDLSIDTTISSPRMGGRRSISFGASVTRGSTRESIPPVPILPPMPSPHQPDTPSTPGYSYQAALGNALIAASHAESSKGTHGDLLQILNHDRQPWGFNYSTYPHAIRVWYGDHDEKIAENAVRWMENTMGRDKCRVNVVKGADHALMFKSGVVVEVLEYISECWRSGESVTQNIQGSLLTWTPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NH89</accession>
    <name>A0A2R6NH89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001245">
        <property type="protein sequence ID" value="PSR71730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NH89"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="155" mass="17519" checksum="E720E0F0574BF8A5" modified="2018-06-20" version="1">MSDTEAGKLEHPLLLPPVHRQEDLVKYRYSGVPVAPEYEREGAEDFQPGKHGSRIPSPFSCHIQDPQEQGPPRSSTQQQTRDEEEEHPTLDSARSVSPPVSTVPVGPTRPTPLNTMSPKVKLQFYHRALYWWTFEKANGAMVDKELRSSLSMIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHR1</accession>
    <name>A0A2R6NHR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHR1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="79" mass="8607" checksum="4803CE1DD7E75D91" modified="2018-06-20" version="1">MASKHVGDIGAQGFLSVCAHGFDETPNEPKIAAAMLTALVLGRVLRRFPSAEICDGERSHVPHDFTEREMHPSLTFACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHS1</accession>
    <name>A0A2R6NHS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001242">
        <property type="protein sequence ID" value="PSR71831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHS1"/>
    <dbReference type="OrthoDB" id="2964597at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="300" mass="32844" checksum="D86D1CA570564A1D" modified="2018-06-20" version="1">MSQREKHSPTSRSNIIAAFRNSLSKSQVGSFIASRTGNGATPLSVPKIYHPNVGCEPDSTTSASSECALPNTVDRQPRRSSLSEVKRVITSIVNPRRSRSGSLASLFTVPLAASRSPATRSRAHTVSSIDVSPSNGSGNSDITPPLTPDFFNTPATSFSDYGATPPDRGYKLTEIALPFDLEEEARPRDPLLSEQIRAGKMPERPICYDTLIADISYESPSQLNVDHIADPAVPGEWLGLEETLELSMRERRASDGEEFYSGEFSKDPYWPPVKHDTAWVLKPSLSSSCLRELYTLPVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIH0</accession>
    <name>A0A2R6NIH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v11988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001210">
        <property type="protein sequence ID" value="PSR72140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NIH0"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="635"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR72140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1362" mass="153756" checksum="09A41A4AB262BD21" modified="2018-06-20" version="1">MEPHPHKKFSLRSLRLRFKSTSSIDAQAVRETASERPPPHRTASEPPSAFQSGSHNGFSSSEVYLEPARSSTTDKGLPPIPASQLSSPVSPAAYDQQAAWPLPTTQTPVKTNNSLQMPAPYTPSSSPEVQMPMPQTEELPPAPVPMPIPQVNGFVPSKVDPTTEHQNQGEAQSYYAIETSSSVGGSAVDGLAEIAGKLNDDDDVAQRSRTEKAMGVLEDKADAVNGQVSLVSQVVQPIQALIEATGAVEAIKNGLNSFMEDIPWLMKSLDEVAKIHPVVTAAVLAFKAVYTMEMTRRENDRRIISLHVSMKDMIQILVQLRDIKDPKDVGPDGRTLEARLQSLSDNAAADIKACANACETYIKKRLLVKVLKGKVWESKLIDFIGTFTKRRAEFEFALAIHTAKAVESMKRTVESIDEKVAALTALLRDQFCHFTPENEIELARKVEEKGGVQAVKNNDFLLRELDDFQGGVDSGMKKGASSKAGGGSANHATKTESVNERSAQRSTFTLQDLKDELHEDWDTALRENLKTFEGKFALQQRHLEQALSKFIHEENNRLIDEVNKGPHDKIKNEELKMIWKEMSWRRNVKARLFVMTIRDYFSDKASSSTRTGATIEGQDSSSDPQRSDDWAFEYININYLQTIMEAFDDDGSGYVTIMEVNRFIEALPPSLQWSLPQWVAYWAIGWQITSTNYRNKILQLFAHMFAMRPSVLPENRYWVDYYLSKVWKVGVEMTKSLRAPSNVPDNLEGRFKAYVDYEEDRIRKNLEDIRYDIDALDTVYVVAGPGRIEKYIFPLMYLLLKRDIEIFHTAKTQILHNDELWDAAESLLYVYDAVTFRHKDLSALFQQQKLDVDQQMKKFACEIFDYFHNPAILWKMSCLESNVEEDAEGEPEVGQWDSKASVLNYPIQDQHPFKWELYEEKDETPTESDLQASLPLKAILGEWNGFIYTEDTYPLAIMTSFYAHTSTEADEDFQASGFYNAGTYKLSGKCYQDSEGNITVIFTIQFSEEADKQYFIGHLAADGNIIGTQGWDENASGHSYQFILSRLPAETICFRPSPSQFCLNKPRALWKFATRAIRFQVLKKMWSWTYFAERRDLRTRRLELEHRLYYYGRALDEDELADQVRVRQSLTIRDISFYRSIRDYEHRVIPTHTGYMCDACGYGMGGARLVCLDCQPPEAYFYQTIDFCDDPKCHGTTVTSEKREALLEPHVPAHDFLKIRAIMLYRDQPYLDRMAKKALTACRSQFEANRLSSSSGDSPAVENPADKENDSDGDESDVATEPTSDNAENGQVAVDAVPMETLTIDTNIKTPSLAGAAEPVTSISVPEVANEQPSQTSGTKCAVCSVSVQQPCWFCVHCFDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIW8</accession>
    <name>A0A2R6NIW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v11783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001195">
        <property type="protein sequence ID" value="PSR72335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIW8"/>
    <dbReference type="STRING" id="98765.A0A2R6NIW8"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR72335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="140" mass="15745" checksum="6BDEC51594EB5D93" modified="2018-06-20" version="1">MPPKKQVGGSSSSKVKDDKKNKSSKVQKQIAQIEKQQAQAGKSRAALEKEKEKAMRDKAKLDDEKRMKEEAALLKPVQMQKVPFGVDPKTLLCVFYKAGHCDKGNKCKFSHDMNVGRKVEKKNLYEDNREEKLKGAVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NIY7</accession>
    <name>A0A2R6NIY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001193">
        <property type="protein sequence ID" value="PSR72355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NIY7"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="134" mass="14904" checksum="F44CDC46B2411504" modified="2018-06-20" version="1" fragment="single">EAKRLLDEGEISRTSGVEIIMLACNEGSRLRDVIHTRIVGKPLKKDDLTIMLYLDEAQGLLSMALHDGTMYDAFAYVAAKFLGFGFVLVTLSTNSTLAEFPTTLPSYPLARRTLPHPFTEFGLLRRWTGPISSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJC4</accession>
    <name>A0A2R6NJC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001176">
        <property type="protein sequence ID" value="PSR72469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJC4"/>
    <dbReference type="STRING" id="98765.A0A2R6NJC4"/>
    <dbReference type="OrthoDB" id="3266922at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015304178" evidence="2">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="233" mass="23960" checksum="A8D71E89618C84FC" modified="2018-06-20" version="1">MKFEIIAVLSAYLAVANAHDGPHAFRGRHANIARQVTASASAASSATSSAPSAASSGATPASAASVSAPTVPAAVTTPDSVTISLPTGPSGIPPLVSLTSGMPSGSTLPLSQTFAAGAEPSYSGAPPLPSAFMFVQGQWPAMDVVAPTNSSQVQQWMQELEGVDIPDLQPTQDGDCATDPAFALDGQNRGWWTCGGWTRDTDIVQCPDKLTWGVSFDDGPSPYTQFVIKLIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJY8</accession>
    <name>A0A2R6NJY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v11390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001139">
        <property type="protein sequence ID" value="PSR72695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJY8"/>
    <dbReference type="STRING" id="98765.A0A2R6NJY8"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR72695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="168" mass="18818" checksum="7350EAF742B0CA92" modified="2018-06-20" version="1">MQEFTSPLPQPSFGAAPPFAPRPQPSTFSSTPILAQQLEEEEPQVIKDWREKQAAEIKARDEASKAKREETIAKAERSIDQFYEEYASKKEKAIRENKDHEEKFVSDLTDSLSTGTTWERICTLVELQNSQSKTIARAGAGTTDLSRFKEVLLRLKREGEAAPGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NK60</accession>
    <name>A0A2R6NK60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001135">
        <property type="protein sequence ID" value="PSR72774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NK60"/>
    <dbReference type="STRING" id="98765.A0A2R6NK60"/>
    <dbReference type="OrthoDB" id="2688210at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="250" mass="28772" checksum="753260B246543395" modified="2018-06-20" version="1">MASSRGASPEDIQPEILPRDQNERDQRRDQAVRVERMESNPYNCVMPLFSDPAHAVSRQPLIDRGLYNEEAAQSMADSWAIWHADRKACWDKQVEEDDRVARTSNLRLQEQCRRDREKLEAEWNEAERKRPKEPEMDMDAAVGDNLDTRISPFALQKLRSIQHVHLWYFTLDGISSALKEHHSVAEDTMVLTKSEDGVGFKSGSHRASPKAVSDASLSWEQLTECYTEFIKQIKAAGWPKSYMQAHLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKM5</accession>
    <name>A0A2R6NKM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001127">
        <property type="protein sequence ID" value="PSR72861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKM5"/>
    <dbReference type="STRING" id="98765.A0A2R6NKM5"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="376" mass="42077" checksum="EC1224FE1D723416" modified="2018-06-20" version="1">MSATTSKLFTPIKVGTSLLGHRAVLAPLTRYRANSAHVHGDLAVEHYEQRGSTPGTLLITEATFIAQRASGYAHVPGIWTDDQVAAWKRVTDAVHKKGSYIYIQLWAIGRAADPKVLKEEDPDLPYVSASDVQLTGKPFPPRPLTVAEIKEYVQLFATAASNAVHRAGFDGIELHNANGYLPDQFLQNVTNKRIDEYGGSIENRSRFTLEILEAISKEIGQERTAIRLSPWGRFQEMRMDEANLRSTFSYLVSEITKRFPNFAYLHVVEPRVEGSEDRTVQHGEEIDFLRDIWGSRPFISAGGYTREAAISTADNKGDLIAFGRAFIANPDLPFRLEKDIPLTIGDRSSYYTWESPVGYNDYPFSKEFESGKQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKP6</accession>
    <name>A0A2R6NKP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKP6"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="247" mass="27865" checksum="B35137DF17BB054F" modified="2018-06-20" version="1">MTTIEGWEKDKVATLVRRGKVQENLGTRRNIAAVLGNSPLLWCWPTVPPGTGLKYPLANPQDSGAESWPPKDPNPYPNHVFTLPQSPWTYENGSFNPELKPSNKLHAQSSTTRRRKAQPKDVSSVPPYHPDYKPPGDNEAFSDTAPSVDEDGSSEEAEVEEYIVRPQNNPKRLVRRGSEGYEVGTIDREQMLREHVESQVHEPGRYRLYAPDPVTPSESESEGIEDEREEEPLVSKVEHWRAESSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL99</accession>
    <name>A0A2R6NL99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-proliferative protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v10967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001103">
        <property type="protein sequence ID" value="PSR73155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL99"/>
    <dbReference type="STRING" id="98765.A0A2R6NL99"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF22">
        <property type="entry name" value="BTG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="3">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR73155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="337" mass="36500" checksum="84D1BC33400AA51D" modified="2018-06-20" version="1">MATTTSFGALSVTLAQAITYLTRSLIVHYPATTIIKLQLALEMNLTTQFESSWVPSDPLRGSGRRCLTLSPNCLPPRPVYNACRIAGVEWSQWISALGGLELDVFIDPGCVSLHFAHWDAGRFFTVWSEELRLEKKYASPSKTVAQQIILDDTQEDDELFAMLSDEIRDPTWMTPTTSQFPHVPTICISVPDCPPRSISPMSAISSISSASTHSRTSSSSSISSSGFSFSSRGTNDSYGSATTVSISSSCSTSPDEERSNFKLSRREKARQARVFVDASKTEVTNYDGGKTTVLTGGVMLGAVAPKPKPSRLAALAAAAAQRKSISPNSNNWRSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLU1</accession>
    <name>A0A2R6NLU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001120">
        <property type="protein sequence ID" value="PSR72982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLU1"/>
    <dbReference type="STRING" id="98765.A0A2R6NLU1"/>
    <dbReference type="OrthoDB" id="2791548at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="57213" checksum="E48446ACB916DD4B" modified="2018-06-20" version="1">MLALRSELRPGDHFNPLLGLSGINVHNDTTVELLHTYALGVDKYIWHATNSKWNGDTDSVYAARLRSTSIDGLSIPPIRGDYLIQYKNNLIGKHFKTLQQVGVFHLYDGLCAPVIFDLWKATGELGAMLWYHNIKDMTQYLADLQILIDNLLDIWAAIDPRKIFLKTKLHVLLHAIQDIPEHGPLILYSTEIFECWNAIFRFCSILSNHQAPSRDIALSLADMERFKHQVSGGWWKNDVGEYVRGGEKVRAFLHKNSQLQRRLGWVDMSQMVSDNSVGSVKPFSQRKQALTIWASALSALPNSDIPPMPLQADPSLVVEQHGLTLDLFPIDRSNIYLPNDGEDARVWLRCKHLVSQAKDICRSKSWIFFREEGQKNVLFVFNAQHDCRHCGCKLTGEIRIIQEREETRRTQKNLEHAPVERYLVNMHALHNAAAMREILPRHLWSPKPYLNNRMEKHAEYATHLRMTGPTKRAAAVAKSAETRARNKKAKEDLATVRVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NM73</accession>
    <name>A0A2R6NM73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NM73"/>
    <dbReference type="STRING" id="98765.A0A2R6NM73"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="118" mass="12670" checksum="A559EFD45FE316C4" modified="2018-06-20" version="1">MFSGFHSPVAPTDAELATQTLNEESSYRFPSFTANDAVTLGLSIRKRFRASSRHAKGKGLVISVQTIAGHTLFSCTVGDLGGFTGVGDVSLDSWSCVEVRTTIIVISRDVCVRWVCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMF2</accession>
    <name>A0A2R6NMF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative peroxiredoxin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v10639</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001070">
        <property type="protein sequence ID" value="PSR73527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMF2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMF2"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR73527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="18439" checksum="75A25DD1A2D3E481" modified="2018-06-20" version="1">MVNIKVGDTVPQGKFATVPYSPELEDGLACGVPTKFSTDAWKGKKVVIFAVPGAFTPTCHSNHLPPYLQNYDAFKAKGVDVIAVLSANDAFVLSGWTRVQNVKDKLVALSDVEGAWSKELGLTIDLSGLGIGLGTRTTRYALVLDDLVVKYIGDDLSDIQDEKGAGVIKIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMZ5</accession>
    <name>A0A2R6NMZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001063">
        <property type="protein sequence ID" value="PSR73757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMZ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="85" mass="9605" checksum="429443B04FB71AF2" modified="2018-06-20" version="1">MPTPVIIDDPEKGTSELLEVLSPLRPQTDEKALPSVSVSVAIPSTKGFVTPKPSKRKVSRWVRFQLWFNTYRSVINLSIKSHKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN06</accession>
    <name>A0A2R6NN06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001065">
        <property type="protein sequence ID" value="PSR73747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN06"/>
    <dbReference type="STRING" id="98765.A0A2R6NN06"/>
    <dbReference type="OrthoDB" id="2830306at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="923"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1102" mass="124962" checksum="C55538AC4504A53E" modified="2018-06-20" version="1">MLDPDKYELALIQEPYIDWLGLTRANPKWSVIYPTGHRDKASKDKTRSVILVNKRISTNNWDEVECDSTDVTVIRLRTPSGPLYIFNIYDDQTHDRTIGKLIGKMVAIEREETERGIREGANRTSRIAHIIWAGDFNRHHSFWERAENTHLLSRSYLDAAEPLVTALATFDLIQVLPPEIPTLQANATGNLTRPDNVFASPGLAERLISCDAHPALRPPNTDHFPIHSNFDVSLTAAQEMPGWNWRKVEEAEFYLALDEAVESRHIRKHRIKTREEFDQVLEQLTDALVEAREKTVPKRKPSPFAKRWWTADLAKTRFRVKRLARDSYRKRKEPHNPIHAEYKKARNEYGERIRKAKKEHWEAFLEDVDGESIWNFSSYAASEHTDGGRTRIPQLRSTGTHGRTKLSKSNDEKSKALHEAFFPHPGNPPSNQDMAAYPEPAFEFKGITKDIIREVIKNLKRYKAPGIDDFPNEVFICAVDLHCQDTIRLHGKDLGNTNGETRVIIEQSLPRKKGRTTTDSLHYITATVKNAWRTHKVASILFLDVQAAFPSVNPERLLHILCLKGIPKEIVDWLRLKMTSRRTVLCFDNFQSSQFEIKGGLEQGCPLSVILYQFYNSELLEGANRKNGEIATGNIDDVAVVAIANNFDDTHEILRSFMTRRGGAFQWAEEHNSTFSVGKFGLLNCSRVLGDLGPTLKLGQTTIKPAKTHKFLGLLLDNKLKWQAQTERARDKGLQWLTHFRRMANVKHGISLRISQRLYFMIAIPSMLYAADVFLTPIRAGTHPSNKRTGSVSAISRLSSVHRQAAMMMTGAMRTTATDVMEVHAGILPFPLLIDKLCHRAFARLCTLPETHPLQPLVNRAAKHYPRRHRSAIQELAHLFNLAPDAIETITPARYSPYWKPGHATEIAENKDQARESENRWARKNGIRVYTDGSDVDGGVGAAAVLYKPGRRQVKTLQYHLGPSMEHTVYKAEVVALILGMELIRQESSVRNVSLAVDNQAAVSASRSSRSAPGHYLMDEFHRLKARVKLKHRGTKITVRWVPGHMGIKGNEAADRRAKEAARDLMEIRRPIPTSVAEVQFSPVRRPFLPNPEPEPATSGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN53</accession>
    <name>A0A2R6NN53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001076">
        <property type="protein sequence ID" value="PSR73490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN53"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="229" mass="24283" checksum="15C1479EFB9BED2E" modified="2018-06-20" version="1">MPVLAGWPSTIDDGSKITLPNLNRATVAGISVAIVGNILISLALNCQKLAHHRLEHDRENKQEPVSQDPGSQNGLKVTTSGASVNEEEEESGEVTPTGEHPFGGHLRRTTSGNTVLSPVSGVAILETEHLLGDGERAPSYGTHAPANSGTYGKQATALLSRLSHWRKRAKRVASSPDHAHGGASHSLIPIDVVEVRQTPDNGRPDAGTGVKDDGSESDYLKSKLWYVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNA9</accession>
    <name>A0A2R6NNA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001052">
        <property type="protein sequence ID" value="PSR73884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNA9"/>
    <dbReference type="OrthoDB" id="2574468at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="10423" checksum="AF373309DEF033E9" modified="2018-06-20" version="1">MSMKRKLSLDFDDAVEYSMAKRPNRIPFPNSELDTDVAMSDSSSDAGLLTPLSIPDYPFHTRLHSNASTISEGSSLENSPASSRESTPTCVVTVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NND5</accession>
    <name>A0A2R6NND5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NND5"/>
    <dbReference type="OrthoDB" id="2798901at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45692" checksum="84DE767E0BCB8AA3" modified="2018-06-20" version="1">MIHRHPPEIIDNIIDYVKDKATLSACSLVCRSWTPRSRYHLFRTVKLIPSRFELVGQSQPAFCDSTYPPEPEFELLDLKPSPMVTFRAFDAFIAFLESSPHLIGLIRELSIDGTRYKGRSKFRIQPPEERVCQILRQLPKLQAVHLHKISVQIFYDNSRTYGDGLPRTPSILEELLDALAPMRNLEELRITDVTFKCKPRQPSQSESIADSATVVSPFSRLKTFEMWLGHVSNMWLPSFLVEFPFPQNTQVCCLRRLEVNVDRSNLKRVGEFLEIFGPNLVHLGLQLWPMGLEPRHQDPTLPWSFACGILSVASEASHSLDSIAFVLDSPPSPMDLELKESFSHVDELLAGNGNLKVVSVRPRQSSSLFPGAQKRNSRLVSMVAEEFVLLREKGVLQVLDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNP0</accession>
    <name>A0A2R6NNP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001036">
        <property type="protein sequence ID" value="PSR74023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNP0"/>
    <dbReference type="STRING" id="98765.A0A2R6NNP0"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="60"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR74023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="253" mass="27835" checksum="ACE3E5A22645042E" modified="2018-06-20" version="1">MSSTALPPFDVNTQITYVENPHPGWSPGQKTESTPDGKEWQEGEKEGWKVMYTDNDENPIGIVPRPIAFVSSVSETGEENLAPFSWFSMIAHNPPLVSITCLNRDGKPKDTLSNIRLSKSFAVNIISQPFVEQVHITAIDSPPEVSEWDLSGLTKVPSIHIKAPRIKESAFSMECELFQVIDIPHPDTGVATSFMVLGLVKYIHVQNAVLHEDGVVDPTKLKPVAQLGDISYSTFGVPFRIPGREMDGPGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NP74</accession>
    <name>A0A2R6NP74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001008">
        <property type="protein sequence ID" value="PSR74267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NP74"/>
    <dbReference type="STRING" id="98765.A0A2R6NP74"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="377" mass="41465" checksum="5D1AE2C7088A7069" modified="2018-06-20" version="1">MAPEARYTLFKESEAPASPVGWQRRTARERIIFSVSIILGLAAFSFLWAFSPSVLGLTQLQDESSSSTGYQNSLSAPLKQCASSLPPPANPPASVNIWASLSVPETVAITEWLSHPLRNLNVTSADRASLSDNIIFLVEAYRPSKADALAYLSAPVSENLPARYARATVHLGARQDEDGGPVIKDYLVGPLPLGDETSMRELTEIYHRNEIPYNARSFVIPSELTPLLVKIMPPLAEVTKDLFGGVAMGLPNDTLVAGASGPLSFDGSFRRTWISWRRNLPGPWLHPVNFFQYVDFSGTDPEQWKLIKVAKLILYPSDYFDVAFCRSSIIIRSSLTLSLSSKPTTTALSESYPHVPIKLPIPSGRLVFVRMPLQHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPC3</accession>
    <name>A0A2R6NPC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v10284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001050">
        <property type="protein sequence ID" value="PSR73926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPC3"/>
    <dbReference type="STRING" id="98765.A0A2R6NPC3"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="503"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="712"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="946"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR73926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129199" checksum="F792B5526C3BCD50" modified="2018-06-20" version="1">MDTGSGAGQINAKLDEESMRKAKRASLRDLNARPAGQESSRNLDSSLKRHTALTKRMRQSVGTENHDQILKDIESLSLEKYIDEMSGAVVEGVGRCKTEKDVWSAVEIISALHRRFPTIFTPALNSGLSAVLAPPSQATLSGLTPEQREKEDSSRISRQRPVLRVCAELALVDIIKDGPDRSGGEWMMKVIRQLLSNDPSLSSLPLLSTFLKAYSRPYLGIAPPASTAKQLSTATEPGNLSGEATKEANGVNGAFPALSKEEDELVEKDIRDRFKKMCEGYFESVSKKLVIEHDRLQDQDRRNHEAYIRSGEIFEDRQQAYEKMTKGYEKLLASCQTLSELLYLPLPKLKAASHKVDSIQIGGNTGSNLGGDIDLDEAARGGKWEDEEERRFFEDISDLKDYVPKGILGLEEDNESDSEETKEKKEKKEKERVEEEVRKLEEELAGMEVSGEGGEPTAPKTNGNSSAPDTEVDAEDDGTTTPTPGSPKTDPSDTPQLALQGPSQLLTALLARLPDATNRAFIDQAAVDFAFLNSKAARKRLIKFMGQTPKNRTDVLPHYSRLVATLNKYMPDIGTEVVALLDDEFRYLQRKKNVVKELADTRRKNVTFLSNLTKFRVVPPHIILHMFKVCLDDFSITNVENIAMLLEGCGRFLLRSEETRAPFSKMVELMRRKQSMQHLDQRQLLLLENAYYQCNPPERTARQEKERSPVEMFIRHLIYDVLTKKTIDKVLKLLRKLDWNDEAVYRTLHKVFTKPWKVKYGNIALLAMLTYDLQRYHAAFTISVVDQVLEDIRRGLEQNIYSINQRRVATIKYLGELYIYRLVGSSIVFDTLWTLVTFGHPEGRPLPGQACTIDMPDDFFRVRLVCVLLDTCGMCFDRGTQQKKLDSFLTFFQLYVLCKDPLPMDVDFMLSDSMEALRPKLVMFKTFEEAAVAVDEMFSVAFQNAGLATGDDSGEEEDEEEGERRDTNEEEDGEAAPLDSPVDERAPSPEAVLLKSSQEILGPSEDDDADFAKELAKMVTDNAETRKVDKKTALALWESTVPPPVMRKKKGEESEEGGEVAGGSSTDDSGIMKFTLFTKRGNKPQMRQLAIPAESALAIQTRTAQLQDKVEQQHLKKLVLDYEQREEAEELRALEARNRAGAIKIRYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQE3</accession>
    <name>A0A2R6NQE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQE3"/>
    <dbReference type="STRING" id="98765.A0A2R6NQE3"/>
    <dbReference type="OrthoDB" id="548295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="487" mass="53959" checksum="AAFC438DB3798121" modified="2018-06-20" version="1">MEEDSEVLDWGNEDDEMHMSESVRAQKQSDAWASGDPDEAEDAVSLGGDDEEEVYPSYESASQDDFAKGQSNTYRQVSSSQQQQQTPSTNGRREQRENSSCQKQPSRKNDSSPLRRSQSIGKLTHALPPKPAVAPPPFIHSPPVQRGTLASSMIYRERRSNGHGKPASSQDLSDYLPPDWEVRYPRNGGREAYYYNVRTHESTWIRPGPTSSGRSSPSKERDSDIGGGRISRAGMIDDSTLSIRREERRPNSPGGSLTYEDRHYRPGEQVSSNGPELGDDRRESYPPSPRVHARAMSPRGINDRLAARSVTPPARKRDSRSMERTGRDYHRDVSPSVAEPNTWRDLPRDAVQAQHSPVLERAWGRSRNNLLPEDTLSRISDDRSIAPRGRRRRSDVEPPLQPLSILQDSHNHSNSEWPASSTLSASSHLPTLVPGVAAAAPSRKISSSTLCNTFGSARASSKSASETEESPRTSGFSSSRQGFNTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQQ0</accession>
    <name>A0A2R6NQQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v9447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQQ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NQQ0"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR74913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="353" mass="38240" checksum="BE3A7E47EF983955" modified="2018-06-20" version="1">MSGTDSAPSLDFDICAAYRRILEDKEISPPLAAILSLTELMINSKAGTMFELVQALNDGAKNLKKRTPNPISLNAGCELFIAFVTLFPHESDSFGGLKTELVKQGQRYAAEALSYRDKIAELALGFIKDDSVILTHSYSRVVMKALLHAHKTKRISVYVTEARPRGLGLKTHAALTAAGIPCTVVLDSAVAYVMDQVDFVLVGSEAVVESGGLINAVGSNQMAIVAKAANKPFFALAESYKFHRLFPLSQYDLPTHNPNILSFPSLPAQSDAAHGTQPGASPGVSSLAIDGNPPSNKESPSFAHRTMTPEQIARNPDVDYTSFFGRRHPHTRGKSESPDSSRLMLKNFRINRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR36</accession>
    <name>A0A2R6NR36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000937">
        <property type="protein sequence ID" value="PSR75066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR36"/>
    <dbReference type="OrthoDB" id="3158924at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="11952" checksum="F9C93234E06D8DE2" modified="2018-06-20" version="1">MLSTFHRWRDFMQCSDHRVAKFMVRWDGPYKVVCAWPESSLYELNLPQHSNAFPKFHSSLLKPHIPNDDSLYPSRAHAEPKPIFDPETGEDQHFVEKILDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NR71</accession>
    <name>A0A2R6NR71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000922">
        <property type="protein sequence ID" value="PSR75162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NR71"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="96" mass="10844" checksum="8B290D0ED2F41AA7" modified="2018-06-20" version="1">MAASRAHTMYYRPPHNEPGMRYAGASGSPPFTTSLTAILGQVRSLFEGSTTERLYPYLDTIRMPRWSTVLVIAMADHRRRISELSVPYFSICNGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRJ7</accession>
    <name>A0A2R6NRJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000906">
        <property type="protein sequence ID" value="PSR75314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRJ7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="244" mass="26081" checksum="F0B97430AE45A24F" modified="2018-06-20" version="1">MLVVWCMLRRRRKEIDDDFEEGYPPFPIKLRKPHEKVAGIDDPPIPFDPYGYGAVSASSPSEGVSGSFAGRPRAASVRRRNPTSSEGYPHSMPPIPLIPLSDDIYRRTTPPAVPTSVGSIPSGSGSSERLAVHRPLQVMNPTPTSAPPARDTKDPMIYLSANRGLEVRAGSSDPLQNASPSGPLASGSHTADGDNTLHGSSYVPFVHRDGGSLPIPNPPPRSRVVEGADTPRVPTDAPPPAYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRV6</accession>
    <name>A0A2R6NRV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v9022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000883">
        <property type="protein sequence ID" value="PSR75542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRV6"/>
    <dbReference type="STRING" id="98765.A0A2R6NRV6"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015348452" evidence="3">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR75542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="181" mass="17294" checksum="8256C172DAB7F609" modified="2018-06-20" version="1">MKNAFVAAFTVAACVGSALAQVIQINTPFQTPDANGQSVQQYFNVPAPPFIWQVNISANTQYGISIHDSQGNTGQSGPFIVQPGSTNCLSTSGSSAPAPGSSGASTPAASSASTGASSTGPSGSSSTGAPSGSSSTNTASSAGSGTSASTSPSPTSNSALINTVAMGAVGFIGAVVAAIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRZ5</accession>
    <name>A0A2R6NRZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000882">
        <property type="protein sequence ID" value="PSR75620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRZ5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="174" mass="18841" checksum="E715D6291FFA02A9" modified="2018-06-20" version="1">MTSFERTSHRSHYVDGPGLRITHTIPTLTVSQTKLLGYAAQQQDVHANTDADTDGAGFSERSQRSCRLGDSPDGENSAGEMQRGEDIRMKINVGLPSDTDLDRVLDAEMASTEDSSEDVSGGQKRPDESGGGEEARYVVPTDSSAIYHLVFYGCVRIFDGSFADLFASPVAVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRZ7</accession>
    <name>A0A2R6NRZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v8926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRZ7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="88" mass="10038" checksum="6C139FAA8A99D620" modified="2018-06-20" version="1">MVDENASQLAPRELFCKVFQCLSPFGSSKARSETRVLPKRLGVWVMVEIAETPAGLRQRDVGSEIAPEEMYYALEYFSRDSLELNHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS92</accession>
    <name>A0A2R6NS92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000881">
        <property type="protein sequence ID" value="PSR75724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS92"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR75724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="104" mass="10963" checksum="2D210964AD0ECC9D" modified="2018-06-20" version="1">MVTTHAVRSLSLPTLSQSQSILGIRRTGVYCQTIKHIGFGPSSRFQNRYLERVNGRGGKMVGCSTPVSNGLSSHLTAPRPPFEPIASPSFAAGVAATVKPPGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSA1</accession>
    <name>A0A2R6NSA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v8922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000880">
        <property type="protein sequence ID" value="PSR75738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSA1"/>
    <dbReference type="STRING" id="98765.A0A2R6NSA1"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="70007" checksum="095E12A991E2AD8A" modified="2018-06-20" version="1">MTAISHMVAGHLHCEKCLMEYIESGEDAMEALCPECRAPFSLATPDLRYVPPKYHAYIVPSIRRVYIPSSATTVQLNAQNASLTTKLAAAEKLARSLQRDKELLIDRCESAIAKSDAIAKAERQFRVKCETLEKEAREMKRETLRLRERERDVKGECEEARFREQEMKVENEKLKKEVGELKKKYGEMKGKYKALMQESPTLSSPLSSSAPRTSRTQAPKRTSSQAFASPRRIHNPSNPADQDPSARLMAPIPKRPRLTTRIWQPTVVPDINQDSIKAEEDEDDGSSDSDPEIRYFGKPISLRESIGISTTRPNEPHHKSGPSTRSAVALRPLLSGEESTTMPGRKGKGRVWVEHNTSSPDLQFPEVTAARTRKRVMVPLLSAGHQSPQPSTSRKLPPPQASASRSTLQPNNISLVPRVKAKGVARQRPSRSAHPPSNSDVFSSARAEPSRSRGLVSIGPSRLLTDLSWSDTEVSTTGEDEDSFMTAMEQSQQQLSRASSHLDHPPSRSALRRKAEDEFRFLRFHDMCDCGPVGFVRAAWEESGRNEKKANRLLNDPTWRFKGEEPVLPRATAGMLGLEAPSGSTREKGKGRARDDEDDRSGDRSDGKRKRPAVYKGRIVSSDGMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSI4</accession>
    <name>A0A2R6NSI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000874">
        <property type="protein sequence ID" value="PSR75832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSI4"/>
    <dbReference type="STRING" id="98765.A0A2R6NSI4"/>
    <dbReference type="OrthoDB" id="3268787at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="402" mass="45559" checksum="808E21A5499620B4" modified="2018-06-20" version="1">MPARQDSGINSSAPKRHSTLYLHDGDIILSSPNNDNTNVLFRVHRAILTHHSAVFSSILSIPSPPESNEIYEGAPLIQLTEDANDVEALVNALYNPSTIAPKKMDPDLPLRVRGILKLAEKYQIDSVRQLIIQRLEVDWPQNVSEWYLFVAAKERERILRNKSIHSPTIDSMFPEPASAIRLAMEFNIPSILPAAYYMLVQTDPSETWTIATQNSAARWQLLDNTDFVHYIRGRHELATSLTSISESIYGFSDSWSTDGREFCHTGRCDDILAKKSVDLDRGSQENAILPDPLKLLYQAQQKLEESIERERDWSDYQDDDYAPELCYTCNMAVQSNISREMRKIWGRLPQTFGVYLKQSLELSDEDVRASVFFVSNNPDLACSESRTTVAAFVKLGSHFDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NTX9</accession>
    <name>A0A2R6NTX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v8239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NTX9"/>
    <dbReference type="STRING" id="98765.A0A2R6NTX9"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR76642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38303" checksum="0B6480F4F91933B8" modified="2018-06-20" version="1">MAILSSAPLQFVASIPAVTRAFTAATVLLSLVYYWLLWTRDQDFSVPYLVLVPGSSIFYPWTFVTSAFVETSGLELIFTLITIPASLRYLERLWGAVETLKFVVVTIAVSNIIAFGLNWLEFMVLRNPVFLYGQWYHGQMALQIGVLVAFTQIIPEHQVQLFGMLKARVKTLPMAYVTLSTVMCIVGFQCPWIVIQFGWLVSWVWLRFYKKNPDTVGGGPAYGDRSETFALVSWFPPFIHTPITALGNLVYSLASRFHLIPLGSSDIEAGGYSQVPGGARAEAERRRAMALKALDQRLAGGTASPATRTSTGTAAGSSRPPAASVGESNKPVPTPESVPVVKDAQDETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NU30</accession>
    <name>A0A2R6NU30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v8266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000837">
        <property type="protein sequence ID" value="PSR76669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NU30"/>
    <dbReference type="STRING" id="98765.A0A2R6NU30"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR76669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="583" mass="66145" checksum="E20D03AD1E6DD5AA" modified="2018-06-20" version="1">MSDWKASFSKGIVLFRAEKYEDALANFSEAIAMGATGFSVYDSRAAVLDKLGRTREALLDSKQAIYLAPDQWQGYARSAKLFRKANKLNSALKMVDMALKRVKQNDTKRRQELEALRAEIELAGQKQLQDRRRTFYHFGKLPLELATTIFGLIVESDHASVIRLTQVSREWRAVVLETPFLWSTLSLSSRHPVEKAKTWKQRCGGLLKRLHVRSGDMTTIWGVQELRTTPLSFLRALSLKEVRMDHFFNILPTCTPLVIQNLEYLELDNLVAQKDIYKLCAGEHMRLQTLIAKDTPLDWPALANNCSKIRTLTFRAWFDETNLPDFIWLLHRNKQMETLEICFLERPPMRLPLLCPSIPRDLPARIDMPNLARLSFTGGSGLPSIMLIPYLTLRHVQSLQFSKIRVPLDAYLRRLQGDGAITSLKEFKMNHCMLADPAVLVKLLHDATQMETLELECYSDAGHIAEALAEGTRVPCSESQDPSRPSTVLCPRLTRISFAHSLDLREGPLIRLVKLRNILPINPTVDAVSPVPQASADGISRVISLVIDGCARVEGGTVSWLRGHVPDLSCRFDVKKEVRRRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NV34</accession>
    <name>A0A2R6NV34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PHLCEN_2v7944</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000798">
        <property type="protein sequence ID" value="PSR77343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NV34"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1139"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1005"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PSR77343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1448" mass="166872" checksum="D0322032FD6771F8" modified="2018-06-20" version="1">MSSPPAEPVAIPQPEVEDHPMQGVEEEVDEDIAEAPVSDDSSEEPEEDEEEEKRIREGFIVDEEEEEEGEDDEEERRRRRKRRKRRHRREREEEDALEEDDLDLLEENTGASFKHRLTRLRRAHDSVSPPAPSSSRRKAVVESSDEDLDNDDLELPQVQDIQNIWDDDRAAGRDDEDDVDMDDMDNFIEYEEEDEQGGGMDEEEREERRRERRRLEKERRKALGSRPELSGIDANAWDEIYEVFGDGHEYDWALNEEEETGLEDELPKLEMKYQDVFEPSEIRARMLTEDDDLIRAHDIPERMQLATSSLSQSSTLSLQNSLSENDLDDAASWVITRLGARKEQDFFRADGQYHRFLSDLVQAISCALRFLFVQEFEVPYIWTHKRDYISYFNPEDLKIKVELLSLEDLWRVYAVGQKYRSLLERRNALDSLYSRLGVSDDYFDNEVRKKVETVEMVADATEWLGMKYREDKKHQFEIHFHDDEQTDTKKRKMPSRVSAYEVAKKSVVAKLAQGFGIQPHEVVLNFISSENTHFLEEQDLEPLAYAEQFVDPDLNKTQTPEELLKRARMILSTELGKDPLLRQEIRKRFKADALVSVLPTDRGIAKIDKHHPYFNFKYLMNKRAVDMLQSAQFLNILAAEAEHLVTVSVHLPAEVKADFERRLNDAFASDSYSDTARSWNEERLRVVQETIEQHLIPVAVKWTREWIREEAEEFLCRHCAHTLRNRVDAAPYITPELRPGETPSVLAMSWGKGDPHKDAISIIYMDEAGRLREHTRIDNLVDAENHEEFKDLLRRRRPDVIVVGGFTMATTKLAQRVKEVVNPRPPEDIEGVNNDSQQNEETFNIPVIYVWDEVAKIYQHSKRAAEEFSAFSPVARYCVGLARYAQSPLNEYAAMGPDITTISFDEDYQQLIPREKLLTALERVLVDITNKVGVDINRAVTDAYYQHLLPFVCGLGPRKAQVLVKKIASMGGTLVNRDQFIRNGLLTTKIFLNAAGFLRITQDPEVPKPPKNRHGEDADIPDPLDSTRIHPEDYELARKMATDALELDEEDIHDEHPSHVVSLIMQDEDNEKKLDELNLDDFAVNMYETNQDKKRHTLIVIRSELLKPFGESRKPFQMPAAWDVMTALTGETSKTLRVGLIVSALVTRIKPAFVSIRLDSGIEGVINSQYLADMEVNKIDSFVTKGQTLAGVVIDVKLNMQTDSFWVELSSRPTDVGVGDSHFRQVKHDDAWNHAQHERDTELQARKKRAEIDKTRRVIKHPNFHNFNAGQAEVHLDKQQRGDVVIRPSSKGVNHLAVTWKVEDKLFQHIDVHEPNADPTGQTVGNKLIVDSTHHYSDLDELIVNHVQAMARKVEELMAHDKFKQGPEEELHLFLKNFVAANPARSAYGFTLNRKRPGHFNLCFLANKNSTVQTWPVRVSPEAYYLFETPAAGVPELCDAFKVRLCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVJ5</accession>
    <name>A0A2R6NVJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">PHLCEN_2v7803</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVJ5"/>
    <dbReference type="STRING" id="98765.A0A2R6NVJ5"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="187"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="533"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PSR77613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="617" mass="68723" checksum="8F61EDEE0DB2CB33" modified="2018-06-20" version="1">MAARNVKGADLGKLITVRGIVTRVSEVKPLLLVNAYTCDVCGSETFQDISHKQFTPIADCQNENECKKNGIRGSLHMQTRACRFSPFQEVKIQEMADQVPVGHIPRSMTVHVNGSLTRQMSPGDVVHLGGIFLPIPYTGYQAIRAGLLTDTYLEAHHIHQLKKQYTEMEVTPAIEQALLDLRSDPGVYQKLAQSIAPEIYGHTDIKKALLLLLVGGVTKTMGDGMKIRGDLNVCLMGDPGVAKSQLLKYISKVAPRGVYTTGKGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMEETDRTAIHEVMEQQTISISKAGISTTLNARTSILAAANPLYGRYNPKVSPVENINLPAALLSRFDLLFLILDKPSRDEDERLAQHVTHVHMYNAPPELEFETIDPLLVRHYIAGARQRRPTVPPDVSNYVVESYVRLRKQSKDEEEQKKSHSYTSARTLLGVLRLAQALARLRYSDEVEHGDVDEALRLMEVSKESLYDDGDKSAERDRSDVSQIYRLIKDMMNDKRRGGKSKRKPKRRMGKGPGGERDMDVDSDEESNEEMSMVDIRARVLASGYTEAHLMTCILEYEQLDVWMRVANGSKLTFIAEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVL4</accession>
    <name>A0A2R6NVL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000787">
        <property type="protein sequence ID" value="PSR77624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVL4"/>
    <dbReference type="STRING" id="98765.A0A2R6NVL4"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR77624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="172" mass="19511" checksum="7F79A45739C56797" modified="2018-06-20" version="1">MSVASPTLLPRSALFPNLLPKPPQPHPIPLPPYGQKPLRFNATRDLVREMDDLSDEEEEMDELNIDLKNRGYNFLVPIGKMLTQHEEKNDADDDGDDDDDDDDDDEEDEEDDDGEDRDETSPSEDNSDENEDEDEQDLDAEMEDMDDDSGNITTRSDEMDESGYEEAPSSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NVP8</accession>
    <name>A0A2R6NVP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v7935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02000797">
        <property type="protein sequence ID" value="PSR77370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NVP8"/>
    <dbReference type="STRING" id="98765.A0A2R6NVP8"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR77370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="359" mass="38236" checksum="FE577101163DE7BE" modified="2018-06-20" version="1">MYTPLALIEAIASFALSAQAITPNNLVSTSLSGALSAVKYTSVGGSGSYNQVTNMLPGEWPSCNANPSCITAPKAVSGNLAPFDEDITVNFRGPMNLFNMAVYQPANTTAATWKRVSNWAANQQPDNMVFMNNLGGGNSGEWTICGGNSQSYANGDWTSTVATPNEELFPGNLPASKEINIMTGTTCASGSCEGFSRGTANEGWAGSKMFVVDFEMPEDPSSLPAIWALNGQVVRAAQYGCNCRGMGGDGGCGEIDIAETLVANSPQAISELYSFKGATGTGDGNYFPRPDNGRDTLAVIFDIKTDAISIVRLTKFDYTQTQLPRSLIDGYLTAPAKGISFATNQRRSERRSFFHRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NW97</accession>
    <name>A0A2R6NW97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v7516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000755">
        <property type="protein sequence ID" value="PSR78184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NW97"/>
    <dbReference type="STRING" id="98765.A0A2R6NW97"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR78184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="304" mass="34848" checksum="AE027F73D8CF9399" modified="2018-06-20" version="1">MGIQRTPELLDIQSRKPTALVPIRVEFETETHRIRDCFVWNLNEELIKPESFARTFCADLDLPPNPWAETVANQIRAQLEEHEGVASMDLGLDAMDVYANNEEEIPECRVILSIDVQIAAYHLMDHIEWDLLSPLTPETFSITLCAELGLSGEAVPLVAHAIHEELIKHKRDAIEWGVIGGDIHPSTAEEHGTGDRPRDRSGLSLLKDKTGLGLGWGRAPKDGRGPKPLRSVWRDWAEAEEFRTRFEVLTAEEVERREIEKERASRCVFRFLDEFKPVSELRLTSRLRRETSKFQNQAISRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NWM9</accession>
    <name>A0A2R6NWM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000738">
        <property type="protein sequence ID" value="PSR78500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NWM9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR78500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="119" mass="12602" checksum="5D3A807494AC8305" modified="2018-06-20" version="1">MAEPIYKDKSPKTKDAQARPTVVEPLETPDTDLTGTAGEIPTKKSSSRVGKRTKKVNDAGTKQKVARAVKKVAKTVIPANGQAGASIDKAVGTPRITEHTRSGRVRKPTAIVAAMTDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NXH7</accession>
    <name>A0A2R6NXH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v7108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000705">
        <property type="protein sequence ID" value="PSR79250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NXH7"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR79250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="108" mass="11741" checksum="B4AA79153108AFCE" modified="2018-06-20" version="1">MSNGHIGAQGQRGPFKSRGKLLFPYLGISQNCTAKTSLLTLFLSSFTEPSPTSSTMPSQKTFRTKRILAKASRQNRTTPRGVTGDAPSSTSKPPTTLRFRLVDSPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NY53</accession>
    <name>A0A2R6NY53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v6891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000681">
        <property type="protein sequence ID" value="PSR79845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6NY53"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="105"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="9">
        <location>
            <begin position="1439"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1569"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR79845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1818" mass="201173" checksum="A36CC1D58B314DD2" modified="2018-06-20" version="1">MRSAHYTSSDSADDQSSSLPDPNQRPTFGPFTRVQPEQRPSDDSTLRSRAVFIFLRSLGKVFFLNGLEYTFYLPFIVRRAWPLSPHGVMLQRALEPGEVEEAAISHEELLPTIFTMVNPFAEASAVGLTTCIRNGTPQSIDDDDPSEPTASIPAQEHVLWVSGRIRNTDSTDLMTLTINMETKMFSVWRYTYVNPKDYPHPHRRAADRPSSSKHRQSLSGVLSPRQPSYVTAPTRPYSPPEPLPLASLPGLPPALNSTMPMAALVPGAVPNAPVVPPPVVKGRRNSLGQHDVAEQMITGGRVEANTFNVDPVDHARMRPAYWMERLYSEEISQLDVASWQNITCGIFDRRWDGSAECARFAVCLPSSSTVVILPLLKSDEDKSISVGTAERLLATSVAPIRALRFKVLDLLMLKPDGTLSILTHGTKELPLKILPSGPASADASPISPKMRIVTLKNAVESSVTLCHADGTSVRVSLNLIPRGTIAVQCLLIFALVIPAEVFFTLHHRFLLKWSAVGFVDSDTKGGSFYAMRDAIYEILGINDDTNAHVAAGYPSTKDNTSKSWEALSLSSSASRFLSDPALNNLLLPPSRPVKHATTKHMPHQFHSSILSGLHHVAQGLLLATIHHEALMRLVPVICKLALPVRPEWADYWKRLFPRALGPWPSPAKSVTEYLDDRLPVWPPDIFSSLYARINNPDWDAPDVPTWKLIFPPGAEASFAFGNMDPLACTHQVTAVYQSLADGKTDCRKRAQAALKHMVRAAENSLGLEKMMERLPLGLAAPLREAARTCQLSPSGDWPIAAYQLIGRNDLAEGANNPPGLLLNNGYRSVKDYLLPTISRKSINEHGEDVRLAISGELAATSGVELDLDDFTEIRFGQDKRVEEVARMLCSSTVPAIKAPERPDLKEHQAQVGRLAERTLALPLGRAIFTFGSVQVVTREAFAIPKLEFSIRVQPQNLLIVPENGKIPMESSSWGEFHNGVAAGLRISPSADGVESSWIKFNKPSELTPEHAGFLFALGLTGHLREMLTWHTFAYLTPKHDLTSIAVLLGLSAANAGTSNRHVTKLLAVHTPALLPTPSIDLNVPLVTQASGIMGVGLLYMGTRNRRMAEVCLSQISRKDLVQQDLSNEYREAYTLCAALAFGMVMLGKGSHTPADLVILSRLRVLVHGEGHSLTGVKPARPSFDINLTSPAATMALGLMYLRTERQDVADILSIPDTTLALDRIQPNFLLLRTLGRALILWDGITPTTEWLSAQVPLSIAEAMEKKLIGKSVHESFELAYYNIVAGCCFAIALKYAGTAREEAYALIIRYYDQFSQMTYGSGPQFDHRIKRAAIRDGLNLISIALNMVMAGTGEINCLRRLRYSYGMLNQLFRYGTYGAIHISLGLLFLGGGRYTLGTSDAAIACMITAFFPRFAQVSSDNKSYLQALRHLWVLAIEPRCLITRDVDTKEVVYLPVKIKVKDSKDVGTTQLIAPTLIPDIDKLLSIRVDTPRYWPFYLDIANLPHHKESLIRSQTLFVKRRTAFLSYMEDPKGSRSLFVRSGSSTADAATLDFPRLKHADTHPATDLHHFISSHSNDVLFLAFADRFCRNEGQTDEEKLFHAYCHATLLDSILQDKSRTMQSHLTLYRYRKMSIHSPYFGLAQQDLRFAAEFYGKIFERRFSGRSENNPRPPLIRESTLHAALHELDQKLEVLRSRPSFRPMLREYARGSGVPEFEHDSALQKVSHALAWYLQRNNVPVSTLLVVLKALAVSSHGRCLKAPPPHGTTDVPVLDEAIKAVLHATGTQLMTSIGSGWSVRSVAEILETWHMEEDAQAISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYG9</accession>
    <name>A0A2R6NYG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000656">
        <property type="protein sequence ID" value="PSR80357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYG9"/>
    <dbReference type="STRING" id="98765.A0A2R6NYG9"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR80357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="90" mass="9538" checksum="469C341DB5051E6B" modified="2018-06-20" version="1">MDPLAGMDSSTDDDAASQTTEDDPQVPEHREPPPAPTPAPQPAMPSTSTRAKPNYELRHTMRGHTSSISAVKFSPDGTLLASCCMSSLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYR6</accession>
    <name>A0A2R6NYR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000644">
        <property type="protein sequence ID" value="PSR80661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYR6"/>
    <dbReference type="STRING" id="98765.A0A2R6NYR6"/>
    <dbReference type="OrthoDB" id="3363386at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="708" mass="76173" checksum="114A8F18F986B63B" modified="2018-06-20" version="1">MATALQFPAFPRHGILLNPSPSTSPYYHTTSLPGTPRLISSLSSLSSSASSSSPHTSDADNYFLTYAAAKDNQVAPQAASAAPASNATDPGLSRENSKKVRPGSAPHSRRIRFAPLPEPRREDDALPDVFLDDSVENLNYFPVSHDSLDISRSNPSSRPSSLLLGTVVNLDQTPTDSTPTLSTSNLIGSTAARTSSVRVGTTNVGSSDKEDHEWDLCTPTSPNTTFSTELPGSCLESPVTCRNEVPRVKERRWSTKLLKPLLGPLGRNHGISTEDSLGANQFSRGRRESGDGMSSGSATPAGGRSRSRESIADRECNFGTPLSRCTSDNIAQKKAQKRKSSFLSSLTSGSGSGASADDGLWRTQSATGDIRRVKSRESEDFRRRSGSTTKAPNGRRQLQMLNGRVYGAKRAQNVNLFASARSDEPEFVEWGYGGMGSVKSAASVGADSKYSRLQGSSALGVASGERSRGRAGVDEEDDGSGMAWLKKRKEQREREKREKEEQAAKEHSQVEKEQMNGADADLPMVEEQQTEATAEPVQENEELKSLTVEVGSDHVTTAVQVPMHLRSLQSHHRAQGIDRAPSSASTATRKTLERKGSADTARAVSPYAPIDSEVETIDQMDVEPLENDPMDGPRERRASASSGTSTSTEDDEDGDADVEDSPKGTYGDDEEEEDEDEKRTRITALGAGVEKISRHKEKSHSVDGVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NYX0</accession>
    <name>A0A2R6NYX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000643">
        <property type="protein sequence ID" value="PSR80729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NYX0"/>
    <dbReference type="STRING" id="98765.A0A2R6NYX0"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR80729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="86" mass="9570" checksum="77809C06F45C6CAD" modified="2018-06-20" version="1">MVALSVTFIFIHGIEYVNWPRLLPLSDIVHYDGPGYRSGHAGKGLGLSVLEPRKFVRPTAKTRPRAASKLEEIEMGTMSTGKNRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ24</accession>
    <name>A0A2R6NZ24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000629">
        <property type="protein sequence ID" value="PSR81022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ24"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ24"/>
    <dbReference type="OrthoDB" id="3265205at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF214">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR81022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="338" mass="38340" checksum="0B8952D2D51315B5" modified="2018-06-20" version="1">MPILPFKFLRLRLKGRSHVPIHQDQYVENAVFPRSPVVTDCIHPELDRKFDLTSSVRCADRSPIVYGYHADLWKGIWNGEVVAIKVIRVIGNSVDRKQACAKNALKEVEIWSSVKHKNVLPLYGYSHEFGPVPSLVSPYMNDGTASLYLKTHPDVNRLQICAEISNGLAYLHEQRIVHGDLKGDNVLICSLEDRPYPLICDFGLSKRLDLTGSLRSTIVKGTVPWMAKELLMPGTTEDEEAACTLTFQSDVWAWGMTTYELFTDAPPYSHLKYRTLFELSMHIADGNVPEYPVSCEQSLEQHVWALLQMCWNPDPSQRPRSDELRLLVRGQVPVNPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ51</accession>
    <name>A0A2R6NZ51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000626">
        <property type="protein sequence ID" value="PSR81096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ51"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="94" mass="10700" checksum="BD54C00807519920" modified="2018-06-20" version="1">MEKLMLSLQAPDLSDFQLLMDYDTDDEGLPLPEPPEPDSTHAMEPVLRDLNVDALAHRIMSIIPSLQSLYLRVSFNEDLYICRGTSVRRQLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZ83</accession>
    <name>A0A2R6NZ83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial outer membrane protein OM14 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v6456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZ83"/>
    <dbReference type="STRING" id="98765.A0A2R6NZ83"/>
    <dbReference type="OrthoDB" id="2553651at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR81121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28496" checksum="0B494A72C8B843D1" modified="2018-06-20" version="1">MSYASVAAHNAPPPSMQPHADPALLNTEAPSHDNIADDAQKVNIVSSDFKQHPSTATSTQDVPYETPPVPVTAPTRAPDRHRAADKARKYAHDAEEEGFYLWNVTKQYLFRPSVAGGLLGVVNVGLLSWAGYSLYTKPYIRHDTRLLATSAVAALTLVGAEGYAAEKYRLTPAGQKEEQRARQEGAVLYNAAREHILRPGVYSGLVGGLNAGVFGALAYFAYKNWNLRWDRKTVSAVTVTLLTLWSGEGYLAKRYRDTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NZB2</accession>
    <name>A0A2R6NZB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000625">
        <property type="protein sequence ID" value="PSR81172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NZB2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="98" mass="11192" checksum="614A44DDD9B5E877" modified="2018-06-20" version="1">MEEHEGQWALNHTPEWYTQRVHRIYCEEWVQHSEICTNSIRSALPPTLSLLALAAWIQRSTKQLSCYYGPQIRYATSSSNGVYGMAPVALNPLAPTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0K3</accession>
    <name>A0A2R6P0K3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v6274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000608">
        <property type="protein sequence ID" value="PSR81765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0K3"/>
    <dbReference type="OrthoDB" id="3266974at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR81765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="476" mass="53680" checksum="1B48F9C8006BA9AF" modified="2018-06-20" version="1">MVYKLDHKTFALQADNGEQPVNNISLGFLWVSFTPDIYKKKQDQVRSTYTGNDDPAFDLKRPRNIPFSRLTADGILQARPRAQGSYKLGVHDDYARHLIVFWAAQTGDVAHVAAALALDPLMDVAIIYAPELESQANAAYDMYLNAVVSGRIGSARDYEKLGAGEGRLRMMKKTITHPIYKGLCPVDETGRYKIAEIGLSGWRQQGEDVREIFEDTTLWAYKNRYGARFEYPTVSVFGATQLIADAYNQYKARGEVREFHEFMGRALSKRMMIQTEIDAWVSRKFVGKKTRKLLLLWSRYSGQYKGGYNPAGDSDPEGQKQIIEFSQKKLDFTVITVGHDSPNATNPRGDVHFGEFWNEDPFVGHGRPGQASLYCNLIKNYNIVQIGQKTGGMDSAALVGIPTIYVEDVGSPSLARMQKWKEMRRYKGAIVSQPPTALGKKIRGCYPAVPGYQKQDLKVLEQALKAMYADVWNPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0L7</accession>
    <name>A0A2R6P0L7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v6009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0L7"/>
    <dbReference type="STRING" id="98765.A0A2R6P0L7"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR82576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="308" mass="33893" checksum="678A7CC6BE1746A4" modified="2018-06-20" version="1">MSAPNECTDACFSGEYPRKLTSRWTEGLISYQVFAMKVNRKVGTSSLRQECNRVTSTSTTGKIEQIAGVECYVASPTGDYAKDKVVLFLTDVFGIPLINNRLLADDFARNGFKTVMPDLFNGDPRVLDPPPTFDREAWMAKHRDPESWISALDSVVASLKESGVTRIGTTGYCFGAPPAFHLALNGESDVTVLAHPSRLVCPEDFEKYKAESKAPLLINSCEDDRMFPPEQQTIVDGIMGEGKFAPGYERTYWDGCTHGFAVRGDLSDPKVKAGKEGENKSNINQSAAIDWLNPGAFAASAKFFKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P0P0</accession>
    <name>A0A2R6P0P0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v6051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000581">
        <property type="protein sequence ID" value="PSR82618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P0P0"/>
    <dbReference type="STRING" id="98765.A0A2R6P0P0"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="259"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR82618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="384" mass="43371" checksum="801F8D2A4A73C595" modified="2018-06-20" version="1">MLQESHTRLEDPSEGLEEELEEELDEELEEVPLQTQHKEPSEDLEELARFREEWKEEVRRRKGGDDPQTSNEDAVPIKPSNPVKLPELSTPEDKPVILGDVSPGPSNVPGSPKATRPEVPLPPQLLKALDIYRRAIACEQRSELETALQLYRQAFRLHEDVDKVYERLEFSQHTARVHLPTGAADVVASISGPTTASPPQGHVNDVGVENVIRTIEQMTVSTIDSKLPAIHGSVTGLLAKLIATWPSNLSFDPEDEKEPVHLQMLPEEVFVHILQQLDVTSLERFAAVNRKARILTLDTSIWRRYVKAVYKPPQIPDDEDVGALVMKYKEDFRHVYIEHPRIRLDGVYIAVCHYIRQGLSENAWVNVRAYRRALAESGAKVPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1H6</accession>
    <name>A0A2R6P1H6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000559">
        <property type="protein sequence ID" value="PSR83443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1H6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR83443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="55" mass="5872" checksum="0A76ACBA6B4AB1DF" modified="2018-06-20" version="1">MPANNCLHLPLRPEQVTRYTTLPLECSPNCRACAGPPPPPPPPPPPPPPAATRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P1Z0</accession>
    <name>A0A2R6P1Z0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v5572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000550">
        <property type="protein sequence ID" value="PSR83863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P1Z0"/>
    <dbReference type="OrthoDB" id="3229145at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015326475" evidence="6">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR83863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="153" mass="16744" checksum="AE00BCDBE432A07E" modified="2018-06-20" version="1">MLSLKPAFLLLLGSLVSQDAFAFSGSNHVQLLGPQSVNLWKLDNTHSLPKAPYQTDFATEGSVSVQVPLRGSLPYFPTRWFEQPLDHFSNSSETFKQRYWINTRHYEAGSGAPVIVIDGGETSGEDRLPFLDTGIADILANATGGIGVVLEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P2D3</accession>
    <name>A0A2R6P2D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000538">
        <property type="protein sequence ID" value="PSR84295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P2D3"/>
    <dbReference type="OrthoDB" id="3052633at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR84295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="92" mass="10118" checksum="6F75A06F2862BB7E" modified="2018-06-20" version="1">MNIAQVIVTIVPILIGRFLLNLRQLGETQSWNDTQDESRSRLSSHGVRLTTLASIIGNMGEDLDHGPSEDEDEERDDSGLPMEVIASESPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P5E5</accession>
    <name>A0A2R6P5E5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v5364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000528">
        <property type="protein sequence ID" value="PSR85635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P5E5"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR85635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="17789" checksum="618F52196C05E600" modified="2018-06-20" version="1">MNAYSSYKIQVSPSQFPSISTLEFDFLITHSPARAYNVSQMGASPFSAGRLHDLPMHEIYMGSIPCNGNSLIGALITLVKSIPAYHFFDKRIAAFDFDPRGTSVFFSVRVLGDTSRIRAALLHTQPNIVTAREPDQPQTALTKGTKGQEVGCSVFHILYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8T1</accession>
    <name>A0A2R6P8T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v5238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000517">
        <property type="protein sequence ID" value="PSR87147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8T1"/>
    <dbReference type="STRING" id="98765.A0A2R6P8T1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015357294" evidence="3">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSR87147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="149" mass="13857" checksum="2FF65FF92BD3DB12" modified="2018-06-20" version="1">MFSNIKLVSLVVVAAAALGVNGQSTALPSGVDSSSGASSAPSTSASPSSTPASSAPSSTSASSPTGPASSSLSSVASSAASSLSSQVSSLASSLSSQASSIVQSQTSSTNPATNSNTSNSATPVGFNFDGMIGLGVALVGVLAGAGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6P8T7</accession>
    <name>A0A2R6P8T7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v5195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000514">
        <property type="protein sequence ID" value="PSR87378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6P8T7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR87378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="65" mass="7175" checksum="FCA9161740B5221B" modified="2018-06-20" version="1">MRNNDASSHQSAGASPSNTPHKQRSIPVSEQPRLLLRWNSLELLSFWACLSCLWADKIGSKGAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PBV6</accession>
    <name>A0A2R6PBV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v5067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000503">
        <property type="protein sequence ID" value="PSR88716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PBV6"/>
    <dbReference type="STRING" id="98765.A0A2R6PBV6"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR88716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="359" mass="40175" checksum="135F36C9960950C1" modified="2018-06-20" version="1">MYVRGRFEGLSYVLPVLTTRREEINRLVTKEGGTYVKNIERPVKVTHLLCSTGLDEISEKMKYAEKFNSRKEANISMVWEDWLWDCFSAKAATSPPSTPPLERDSAQPEDRGSSQPRQYNNSESHEHEEEELVSLKRVPAVTLQIWGGMLKHRGFEVTAGKLVRSPSKSQAPPLPAHLEKDSPTKSRPKPKPLTRDKEGSMLASFRRSHSFAPATKDTSTQRRPFGRMPTLPDAALSTSIGEEAEQGRPVASSSRPSLIAEDSSKELKSGIFSEKIFRVVGEARCQTVKLAVEEAGGKFVPEDSDESVDYVVVRLVRYGLVCLKFFRDLTIFLFDPAAASSSERRQMRRNEESIGQNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PCI5</accession>
    <name>A0A2R6PCI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v5122</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000506">
        <property type="protein sequence ID" value="PSR88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PCI5"/>
    <dbReference type="STRING" id="98765.A0A2R6PCI5"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="882"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="914"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1211" mass="132618" checksum="9905DB512DBA29C4" modified="2018-06-20" version="1">MFASTPDTEHVARRPRNNHARPAFSQKTPQRFSGERLTHCPPLPTPSPLKSRTMPTDTLEEDDFFSSPMPRVYPTATLKENTSRPRLHAFEDDDDDDGLFQVAASSTFLPPSSSPMPLRTPVKQTPYAKHLPDRPILSVRTTNSPFMSTAATGTKRKPPAYSFTTPERKHMLTPLSTTSAQQDGDDEFNIFAFDRLTAPKFGVVRTPQTRAETELYLKKQEDSMTRLKIVDRDFSGEEAGYDSGVEMGQSDEVTCMRLFNEGTSSSVGRGKAAAHAAGLSLVTKKSLVKEEEVVESMSPGGHINKRRARSRPVSQELLSAANTPAFKSTQKYAATPHMSASKTTGSIAFPSNSNLRGRRQSNSSSSSVEVGSPRPRTRLTSGSLKSRNQSQASHQRIPLNRLTSASSATLFFGPTIPQPESRAKKQSTGAMSIDEPETSARPGVNSRHSYSGSPNESPWKFAARGSPSDGALDEADLFFNSPPEKSFTFSLTESTPSPTKKQHLEPVEQLPKKYRPRDSGIALDDDISDDDGRPGLMALSSEHGSGSMSSLNSESEGEVLVTPGCAPGPDSGWPGVGIVSLDDELYAGLDGDAGEDAFIIRTLTSGTKPSPPVPGEPQRVPGTPVKRNKTAHLLERPWQSAIATKIGFPGFDAVAQDKKSRPRKSLPAAFPTVGRDLRQRRNALTFNNSMGGMDTENEHENEDEEASPSTRKEARYNGLGIGKPPVPLFARSAGPKFRAPWLMRRTSSGAFSSGSETTTSNNTTPTRATVKDLQLHVPPVESPLKKTCQLSSSQCSSQSTSTSGTSTVANSPIVEAVARRCPATEGPQHRRGRSQGQAFDFNKNASPKKGRPRSGHLPGSALRGRPSLPNSEERPGRFEQDFVELEELGRGEFGRVMKVRYNEEGSEETFAVKKSKPFEGVRHRLRLREEVDILKHLSQVASASGLGISHPNVLGYRDSWEEDETLFIQTELCALGNLSNFLWKYGRAYPKLNESRVWKIIAELSSGLSFIHDAGAIHLDLKPANIFVTSDGRFKIGDFGMASIWPRPAPKQDANGIPESTSFEREGDKLYLAPEVLQGKYSKAADIFSFGMTMLEAATNIVVPDQGEAWHRLRHEDFQQVDFGNCSNELVELLKNMMRSDPALRMDAKMVYDHPVVSRAREAMEIARAELGPVFQASALAGVREGWLEEVLGHVEMWDADEGDEAMDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNS9</accession>
    <name>A0A2R6PNS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 4-like WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v4689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNS9"/>
    <dbReference type="STRING" id="98765.A0A2R6PNS9"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSR93794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="165" mass="17538" checksum="27076B173B131DB3" modified="2018-06-20" version="1">MPVVTFNHAGDGLIVTPPAEHTLRAVAYPSLNLVYATPAHVGGCVASALDPRGRYLASGGYDTIVNLFDLSDWICARTITSCDHSITAINFSHDGEFLAIASQGSYIDICAVETGQPMHRVPTLGPSAAVQWHPSRYIIAYCGQTKIREGGPPPAAWISLFGPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PNU8</accession>
    <name>A0A2R6PNU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Virilizer N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000468">
        <property type="protein sequence ID" value="PSR93814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PNU8"/>
    <dbReference type="STRING" id="98765.A0A2R6PNU8"/>
    <dbReference type="OrthoDB" id="2011702at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR93814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1151" mass="127726" checksum="2656B1566B151F06" modified="2018-06-20" version="1">MLLQWCTLEPAGPSNLAAVRFNSAVRVQKITIFPTDDQPFSHSPETVSRTEPEAFFAEVYFNAQILPSARSKERPKPVNALVPTVIAYAGGRMDFAVNMSPEFATRLMIVKGPFQCISMAVYGDIVSEMPPPISTYSPRNIPSFDPILLSSALDPLNFRDPTKLATQLLDLIPEAPPLRLVIRLMFCLKPTNEDWDLPDFPHIYSNLETGGDSLNVESAFNLTSRPVSDETPDASFARFAERVARSVGPKDENQSYYVAGLLFRSACQHPEMARSLLECIDLTKVFDASNMDESTLLDLLDATSNADIARHLSAKWFIDTVKSIENDASSDRETRTVARQLLARLEGMSVFEDALTNTQGDFSRAAATLKEIGEREQSFGIWLESMVTHQDLMDKLGENPTMTVPLQHPPLLFSNTETSVSHEEFVAFLRALIGVSCVLAVCAWADSLPDQYCHEFILGILRLWQGIDGYREILNHLLLLRQMIVRLEYMLDNDLPTKAGIDTEHILTNLAKEPRAFLRPEFIKCILALKPPHCYITNDARLSMRKAALIADDGLLGAADQLLSTMERPPTFENIRALRVALAVLDREINERGDFEVLQEFWKEGSCSLETCLVDLFTILTEQIGDHFSVVPPPRTPLELVSQLFRASSEIIQLLLRLASSYPLTGRVTRVVIRSTADLFVCTDAVDMLYAQTSATCEAAQETRQSCIEIVRSLANLKGSLPGGKLYAEIVLRTLLDHGLHSTNRDPSHHLLQVFCLIDYLLPMPELDGASSDWVQKVVPNTLRELLSFCRALDTENKAHFVRRLVRLDEGIIGVGDWLLQEELKELVEALKALEDPNPPSSYRLVRLYQVSLCLRFLLDLVSSSSSVSTWCVNCIACSTDVARLFATCLQIFIEQDLVSPQYTRILRTLATDSTTVEDTLKLPLALALLRTCQYTGSSSPELTSSLYLAQSLMLTISHDQQTRESISYEISAVVLRLSRTGGVLEGALSDAVVGLLEWLVDPDAPSIVPLHGFSSSSFATFCDSAYASFNAEKKALLEAIRSNLIFVDEPLPIHSPVPLPDRLDITIHDIEDLLHPAAPSPSTPPRKALAQDVLSLVAISPPTALIRSPASTGLTKTYSNNDFRQLRQTPSARQNTSRLPSMHVDVGSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6PVL2</accession>
    <name>A0A2R6PVL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v4315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000436">
        <property type="protein sequence ID" value="PSR97467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6PVL2"/>
    <dbReference type="OrthoDB" id="2734540at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR97467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="350" mass="39784" checksum="213EC3AAEEE90D31" modified="2018-06-20" version="1">MALLPQAGDVSRLMRTCRALYTCHGVRILLSHGAKLHSPRQLKSFHDFSSKTNGYDHLRALEIGIEALNNEKMKLMLVDVLRHARRLEKLKIHDPFLLASDSRVSDAIARLRNLKAFSSCSYSFEGADFNPSKMLTSMKSKLVKASIDFGNGEDPIDVLENFASSLEELEVIGVVFKRKNIQYPKMKTLSVESWRVSEIGPLIHAYPNLRTLDIQGYLRAEHHHNHAAACREMNKTFQLIENSWKTLSYVHTTAIELYALAINCKIHCLHVENICDHKDIVMLAAVLPDCRPSVLRIRSKDKRSFGKIAKIIPAADLIHLNLWIDLSGFSTSRRTDRNFELVSLIFVLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6Q7L6</accession>
    <name>A0A2R6Q7L6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000382">
        <property type="protein sequence ID" value="PSS03734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6Q7L6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS03734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="173" mass="19028" checksum="1DE6D385824F7E6C" modified="2018-06-20" version="1">MSQSILDRRAVFNVGQQPLNSAWGSVDSTLADTLCHDGQPISFHVTAEVQASPFVNDGGVVQLNLIPLTAEEQNGVKAVELIYSSPGQAGDIQDMRIRTDHIESSPKIYDGRQAGYNREDNLRRLAPEKLVKGSIVRVECSLVRYNVGRPLGGSGWRNWRAGWELKTVTLLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEH3</accession>
    <name>A0A2R6QEH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PHLCEN_2v3674</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="MLYV02000361">
        <property type="protein sequence ID" value="PSS06544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6QEH3"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="36"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="473"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="697"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="888"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PSS06544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1361" mass="147161" checksum="B65A10918C415844" modified="2018-06-20" version="1">MLILYGSSYLSHTKRDILLNQIQTCCPEICSVDAHYVHLVSCKTESAEKELSNEASEARKILNRLLEYGDNIQLPGTKEALLQHQNTIYVLPRAGSISPWSSKATDISIICKLGDHIERLERGVVFVVSTSSGCTVTEQDLRTFSHLLHDRMTQVAQVDPPHADSIFKHDGVSPLRTVNLQANDPSGKSPRERLIQANKELGLALSLDEIDYLIDAFVSGSSPINRNPTDAELFMFAQVNSEHCRHKIFNASWEIDGVQQQTSLFQMIRNTEKLNGTGTISAYSDNAAVFEGHSAPRFGVSNSGPDAPNPNLGNLYTSNVEDMPILIKVETHNHPTAVSPYPGAATGSGGEIRDEGAVGRGSKPKAGLSGFTVSNLLIPGFEQPWETDFGRPSHISSAFDIMIEGPLGASAFNNEFGRPALGGYFRTFSESVPTSNGGAREIRGYHKPIMIAGGLGNVRPSFAMKSKISPSAKIIVLGGPGMLIGLGGGAASSQVSGASSAELDFASVQRDNAEMQRRCQQVIDACVNLGESNPIQSIHDVGAGGLSNALPELVHDSDLGAIFEIRDVLVADTSMSPMEIWCNESQERYVLAISPERAEEFKQLASRERCPYSIVGVATSEEELIVTDRLLKQDVIRLKMSTLFGKPPPMHRRDQTRDIAYVPFDSSLSQYLPSTETLPERLSVAANRVLRLPSVGSKSFLITIGDRTITGLVTRDQMVGPWQVPVADVAVTRTSYGFDVLTGEAMAMGERTPVALLNPAGSARMAVAESLTNLAAANFGDLGRVKLSANWMCAASKTGEGAALYEAVKAVGMDLCPALGVGIPVGKDSMSMSMKWKEGAEQREVSSPLSLIVTAFAAVEDVQKTWTPQLRTDIGQPTILVLFDLANGKERLGGSAIAQVFKEIGSEAPDVEDAAQLKAFLVGTQAIRVEEPNVVLAYHDRSDGGLFTTVAEMSFAGRAGIQLSLDALQSSKDPVSALFNEELGAVVQIRQSDLSRLRQVFTESGFPAQSIIPIATVAEGNKEQIFEIIHQSQVIFSSSRADLQEAWAETSFKMQSLRDEPVGAQQEFALIKDDSHKGLFYDLTFTRQPSRDLFRRPKVAILREQGVNGQVEMAWAFTAAGFDAVDVHMSDILGGRVDLAGFRGFAACGGFSYGDVLGAGKGWANSVLLNETARNQFTSFFQRDNTFALGVCNGCQFMSNLREIIPGAQDWPDFKQNRSGRFEGRVCMVEIVPGEVASSSVFLHDMVGSKLPVAVAHGEGRVSFGDEAHQHTLESAGLVALRYVDSTGAPTEVYPLNPNGSPGGISGVQTSNGRVLALMPHPERVATLQSNSWYPPEFDQTCGGVGPWFRLFQNARRWCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QEP3</accession>
    <name>A0A2R6QEP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000358">
        <property type="protein sequence ID" value="PSS06624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QEP3"/>
    <dbReference type="STRING" id="98765.A0A2R6QEP3"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS06624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="207" mass="23051" checksum="8DC2D3824340292F" modified="2018-06-20" version="1">MQPDSQASHCDIFLCRKRFTIFERKHIHGTEVFRSLVKKHTATPISMQQWEIDSSASSVSGSPRSPPTPLDGSAIMPMPPVRSPLRRSQTSPRIPTSPLRTGTSTPPLQRPSVHVSDSELDSYPLRHASAICKATGGGRWEPKPAVQYAGYRIPGTKAQYEIDLERDAEEARIKRANPVIKDGDFQLRVPHELEPHSLGGPYQFSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QET9</accession>
    <name>A0A2R6QET9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000357">
        <property type="protein sequence ID" value="PSS06824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QET9"/>
    <dbReference type="OrthoDB" id="2987506at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS06824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="451" mass="48516" checksum="E8B4237C31E06CFD" modified="2018-06-20" version="1">MSTYNLTISINSADIPLLKDGDYRLCIAKRVNDKYDVVWSGGSFFASNSFAWDAEFQVFGALKFQGGFQVQSNTNFEELKFGQTVVLDHYGVMESATGPTNGPGVFHVQNNYGAMCIGVNAKLGGAWSPIYLSQTPFVSGVVSLTPIEKVLVWFDASSSTGTMLVDAVTNSIEVDFTGKTSQSVTYASDPSTPGKGGWVVGGSALLPSTYNIETDTFSLEIPSAPMLGKLSDIINSQNRLSLTVSSSVEFDTPGQAGAFVRYALGQQPDGVRTWNFTQTGAVVDSKLQAEKDQEDKLAIKFLQDAYLGVLYSFPGPAYNKLTFQISNRHSLPISDEPNVAPVGPAVADPRSSGELRIIYSSASQAADAAKGITALAGNGLSYVAEVHSDDKQWVRARLSLTFPSGNVDQDRHAIVDPLATALFGGGYYFKQPPLFPNTPDFVMYAVKWGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QIS9</accession>
    <name>A0A2R6QIS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v3403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000328">
        <property type="protein sequence ID" value="PSS08913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QIS9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS08913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="73" mass="7844" checksum="5DEB523662E4B505" modified="2018-06-20" version="1">MNAESKTVTWQLSPTTTSEKANIVQMPGSLVILGCTRCLITVEFPAQTGVRRSEASAIVAPRLVLPSSLSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QM78</accession>
    <name>A0A2R6QM78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QM78"/>
    <dbReference type="STRING" id="98765.A0A2R6QM78"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS11026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="167" mass="18376" checksum="A8D34AF4E7DC16C2" modified="2018-06-20" version="1">MREILRKQIREKDTMIDTLLAQLNPTATTATPLSLNTSRLALTQEQRNSYRDVLNYLEKSQGCGRAESRPKIDVSSLEDESDYEEEEEEGEALDDDEGFPGSLFQVHPLPTRCAPAGLLAKAALETRSRSRMSSPTDSAERSTDADSPEEGGIGNLAYFEPGMHAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6QMA3</accession>
    <name>A0A2R6QMA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PHLCEN_2v3329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000321">
        <property type="protein sequence ID" value="PSS11033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6QMA3"/>
    <dbReference type="STRING" id="98765.A0A2R6QMA3"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PSS11033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="142" mass="15687" checksum="24CC5925F0A6DACB" modified="2018-06-20" version="1">MTKISTIASLAARSMHTPTPHAGPSRTLQCMRSHMDSIRLMSSSSSNPLNRPSPPPLPRKDQREFEDLVRKAQAPLSVKSARREQAEAELAMHPDARAPLVAEFEGEVNPTTGEKGGPKREPVRRWGEGDGDWSFKGRVSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6R144</accession>
    <name>A0A2R6R144_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v3164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000283">
        <property type="protein sequence ID" value="PSS18948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6R144"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS18948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8098" checksum="B60BE1ACD635F092" modified="2018-06-20" version="1">MPSLASTIFHTPEPDSHSSKTEHGTERGKEESKPKGNRIRSARVVEIVSPLKFKLKAQGVSTSTGRAGRTSTPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RI98</accession>
    <name>A0A2R6RI98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RI98"/>
    <dbReference type="STRING" id="98765.A0A2R6RI98"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="88"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS29756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="199" mass="21735" checksum="6EC40E6EF1AF4810" modified="2018-06-20" version="1">MAWGTAAPGKAFPPLPPLAPDDVPMNKFTRDSTSWEVRLSNSRRIPYFFNTETQESTWEPPADLSQEQIQNLPGAAEHFGGGGKAVPAGNVQASHLLVKHRDSRRPSSWKEKNITRSKEEAIEILRGYQAEINGSPEKFAELAKVHSDCSSAKSGGDLGPFGRGQMQKPFEDATYSLNIGEMSDIISTDSGVHIVLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIA1</accession>
    <name>A0A2R6RIA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v2900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000256">
        <property type="protein sequence ID" value="PSS29752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RIA1"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="888"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="959"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1038"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1196"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1541"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1804"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1543"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1822"/>
            <end position="1843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS29752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1891" mass="206775" checksum="895C3AC17A7F6216" modified="2018-06-20" version="1">MFTVKATYRAETRKFSFQEHTFPTYEQLCSQLYRVFPIANAYYLSRILFCPNPHAPDQRILVGQEAHNAEEYARYTKQYQGRSFPGALLRFSVSDETPHKVPSNAKDNVVEGESLITVNDAKAVATSLEAGNALEGSDVAETPTPASITESPTAAAERQSHRAQMENERRIILERIRERIHSRSSNSPSISIPVITALPSDVTIAPPASASGTSPLRSYHYPEGSGSIAPWLRTNESNEASDDSLTLKSSSAVPIYRHAERLGRLSEFLSRRENSAQAVRADGNGYAPAQSTAGITPTSSTVDTQVLRNLAEMAVPSAGEAPLPGSQPSPSPPAKDTIRPNRLSQVLSARNMSLSGVTVPKVGPIDHPFDTTPTARPAEWGYSWDQMSRFISGIRDRPTDNVYRSLSTAEQDAGNVNLPNGILPPPYPTPPPVVPSAWRSLRPRQAGSAMEMCSTDGVESMGSPSTTDNTFGPLESPASSTQRLEEPVWNNGNTFDVASNRVLDLGIDFLRRAAELSEASDSRSSSPHHLNGNQESLFSDSRLDTPEQWGGAEEQTKTLGVDHWQQPSVRRAQQNVQAWRTWRPLPPRPSIIGRPLSPSELTAEYAIYNNFPSPSTATASPLHGSSSLLSPPKPFMTSTHGRRWDIGRQGSPSCPPAHSLLSTPSLQSCINMHATGNDTLPSSRSISPVRIRSPSRSPTSCRWSLPTPRPIHPSAPWCHPPSVQPPVCAIQSPIDSFPPVSPSPSQRPLPIYNPYESISDCRPPYAYRFVDAVSMDTEGIKWPHPPLSVSQVSHECGWSTDCEKLKIQIETVKKSLEELRCDFERANIGKEPSYIPHLDMCSGRDKGKGKAENGNATTQPVWNKATVLVGMPIGQNRLGATSSSHSANLDYACDGCKRPIAGVRHKCLDCGDFDLCTTCVSSPGRRRAHDAKHAFFPIDMAGDMTAYLAAKAERLGMKHTGVTCQGCRQQINGVRHRCLDCDDFSLCGACVGSTWARSAHPVHHAFFPIELPWDSDAFQQAFERRKTYNILAPDALEHVGITCDGCNKGIVGIRHKCLSCPDFDYCTQCLSNPDERFMHDLAHAFLPVPKPGDLNQLLAVRAACQEPAPPVVHKGVACNECRDEIIGVRHRCLDCPDFDLCELCISRGAKQDHNSAHQFLELVKPGEVIVHTVYNNDQPGPQEQSANVQQQDTPVVHNATCNLCDSTIRGDRYKCLNCPDFDTCGACFNITSEQHPGHGFVRVDLDNQLVIRDARRLNVVYPVICDECHNPVRGTRYKCMHPSCPDYDLCQNCEALPISVHPLTHPLLKVKTPEASIPSLSKEEGECLKCKANSEAPPLAIFTQATPAQEQTNHVRIIPTSDSMRRIDGLAEVASVQHTDSHYRVPSCHLSQPPNSSELSYANSEHHNMVAAPSLIPPWKPTNVDWHWHPTPPGPMVVPHMLSEESPALQTIVIPPCTLGQSVHSICSGDSPRSSFSEQSPFNPFRDANAVAHDVSVPPSESFSPPGLRTVAPLPMSPPPRLINLDDPATKPVPEWLVKPATSEAQSATLAESSTSMPPLRTPSLEPELATEEWRTLVPEIGTLLKLLFKPPTPEVPSRSTTYMPGGMLAEDPADLIESPPSEHEYRSAVESPLAGEALLTRPSAQIPEMVERPRTNGRSLTDFLGFSTLSRRSPADSPLVVTYLSHNNIADGQFFPPGAEFVKSWRMRNDGSEPWPETTQLVFIAGDRLSPYEGAASKVKVGYVRPGQEIEMVCADMKAPDTPGAYVSYWQLHDGQVGFGDLVWVDIVVAEVNDEESLAASSVIMPPAPSAPSARTNTRESVVPSTFSTPSSDDGSFDSSMSLINVPSSPSGEDDDLYQDSRARIHASPMETHRDLEYVVLYDTASSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RIF2</accession>
    <name>A0A2R6RIF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000255">
        <property type="protein sequence ID" value="PSS29799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6RIF2"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS29799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1382" mass="158049" checksum="A5CD7751ABC182FC" modified="2018-06-20" version="1">MFRQVTKFGRRFRSRGGPTHDNSQSSQEITPLYTPSGSAPPDYLIHTAGVDKDFFPLCTSPVIQMPVPHPAIPDVRDAVDELASVAQQVQAGPPAGSYTERALDRQGVHANFIPFADIYQSFMILGDKFDDAVAESNMADVHETVQALKSGIDTFMEDIQWFIKALDDVAKLHPFVAAPILAFKAVYSMEKTRRENDKRIISLYVAMKDMIAVLVQLRHVKDPTHVGPDGATIGARMQSLADQAAEDIKDCANACDTYSKKKLLVKVLKGPIWESRLAEFIGRFARRRSDFKFALAIHTATVADSMQATVGGIDERVAELTDMLRAVFTEFKPHDEASLAAKVEEKGGADYVQGNDTILRELLAYENAIVLANHNATSKVDDTAAFTEHISNAEQYAKLRPDISERSVQRSSLRELKSDLGEDWKTAVDSNMKVFQRKFSIHKRQLQKELSYVIHEENERVIQKLSAGPHDRIQNEELKEVWQEMGWRRNVEANLFVTTLRDHFREKLDVYGHFPQEAGYSLQLDDWALEYIDIRYLQQLKEALDEDGSGYITIGEVNRFANSQPQNLGWSLQQWIAYWTIGWQVSATRYRDQIRRLFAEMFAMRSKILPENRYLVDNYLQEVWAPGVKLIESLQPARNIPSHIRIKFRSYVKYEEERIAKNLDGIKYNIDALDTVYVVTGPGRLENHIFPLLYLLLKRDVELFRVTRNKVFARDDLFNTAMLNMRWVYDAVAFRHRELSMLFKHKGLDVESQMKSFACELFEFYQDPSPLWKSIPAQTRLDQEAIEAIPDRDVGSSGFDFDIQESYQDFQSPYEIPLGPPADADANAQSITSIILGEWNGFVYSAVQYPIFLMTSFYARASISNDAEFEAYGAHYGATYQLAGRCTKNEHGTVTVNFTIHYSQEFRTKYYSGCLTEDGSIIGSQGWNEDSSTHQYRFILKRTPAEVMCHRPSPLEFQVNQPRALWKFAIRAIRHHLRKQFWSWSFFAKRRETRLRQIQFDIRNYTPFGRPLDPEERAEWAWRRRNMTATDASFYRNIRDTQLRIVPGHPGIVCDACRYRIGGARIVCLDCLPSDGDYCHTVDFCDDPICLGAIITPDMRSYLPSSHVPTHDFFKVRTVLHFRDLPAMDSNARRALVASRRCFEDTQIIEDNERIYFNGGSAINNRAMILKTPRSDKKFIAECRVIMPDDCSEVDPPKFFTENLDTESSPASGSVGLGGKVTCAVCETSLERPCWFCIDCFVQEERHVFICDHCEAKTLLRCIQCSKPYRQPTWYYGTRFDDSFSCNKCIATTTQALNPDKAQHTYLHALVRYLKANEGRTCGQQPADERTMVLEHTVGALSERMHTLDNKLQELKTGLGRVEEMVRTVISKLNAGALDSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLG2</accession>
    <name>A0A2R6RLG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v2597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000243">
        <property type="protein sequence ID" value="PSS30870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLG2"/>
    <dbReference type="STRING" id="98765.A0A2R6RLG2"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="266"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS30870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="546" mass="61152" checksum="7689F71FF4CCD842" modified="2018-06-20" version="1">MAHDARRFENWSREHFISHIRKLEHTLSKPSRITPHTQPATQFTSTPPRVPKPFDFSVHPTRKIALKFAYQGEHYNGLAVQKGYTPLPTVEEVLWNALVYTRLVDPKGGFEGCGWERCGRTDRGVSSAGQVVSLWIRSCLRDKDASNSSVKPSLEDSHPVEESDTFNDGYESDVSGLDDQFGGLNTWDEAPSNTNLNVPAKNPKLTDDDELKYVSCLNGVLPPTIRVLAWTPVEPNFSARFACQYRHYKYFFTSRGLDIEAMRNGAKRLVGEHDFRNLCKLDPGKQITNFNRSIHRADITALGLVSDEGGHGPGQVYVFDLVGSAFLYNQVRHIMAILFLIGTRFEHPSLVTALLNVDPANPLPPFHPDDPPLPVVSTKPLYQMASALPLVLWEGGYRDGALTWRTDKISTNKEDADSGSNQANVPSQTQKDGKDNLFHQQRAVYERSLIRAALDEHFLHATAQHHDRPLEYLPIRPDAPIVEDGVVFGVPLGGGTEKRAAKYVPVLERERSEGVEVLNERWRQTKGTRRVARDTEGDADVEATNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RLW6</accession>
    <name>A0A2R6RLW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000226">
        <property type="protein sequence ID" value="PSS30999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RLW6"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS30999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="110" mass="12545" checksum="B8832922C42CFAFE" modified="2018-06-20" version="1">MTHSDIHGIRPKRRWTPQGECTRLELHSLFPTAHLTLAVRRDRHPDPLPRFYLKKITGIVAPSKAEIEPSQMRYKLPTQPESLSMSTDENTTSECKLQTTVGGPRGLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RM43</accession>
    <name>A0A2R6RM43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v2377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000221">
        <property type="protein sequence ID" value="PSS31045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RM43"/>
    <dbReference type="STRING" id="98765.A0A2R6RM43"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS31045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="76" mass="8596" checksum="0AC6C00A9291CC41" modified="2018-06-20" version="1">MGLRTVLHSVNEFLQNLSTPFVKTLDLPHLRTHFPLLVYSALGFTVTHVVVAPLLSKWIAPVSYGQLKGRKARNNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RPV1</accession>
    <name>A0A2R6RPV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v2202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000203">
        <property type="protein sequence ID" value="PSS32025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RPV1"/>
    <dbReference type="STRING" id="98765.A0A2R6RPV1"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="402"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSS32025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="803" mass="92346" checksum="C0375808DF43133D" modified="2018-06-20" version="1">MTENQKRKRSTSPDEVEGRPPKSRVIEAPRVSDVDPQRRVEREKALAARMAAIELDKLDKEKDGRKEPGFDAKAEFAKLTSTRSGGVYMPPARLRALQEAASKDKASPEYQRLSWDALRKSITGIVNRVNVQNIKMVVPELFSENLIRGRGLFSRSVMKAQSASLPFTPVFAGLVAIINTKLPQVGELVLTRLISQFRRAFKRNDKIICHSTTTFIAHLVNQQVAHELIALQILVLLLERPTDDSIEIAVGFMREVGAFLTENSPKANASVYERFRAVLNEGSISHRVQYMVEVLMQVRKDKYKDNPIIPEGLDLVEEDEQITHQIQLEEELQVQEGLNIFKFDPNYVENEERYKAIKVEILGEGSSDEESGSEESSEEDEDEEAVEEKEGIEDRTETNLVNLRRVIYLTIMNALNYEEAVHKLLKVQMKEGQEIELCNMIIECCSQERSYSTFYGLVGERFCKLNRVWNDCFEQAFVNYFTTIHRYETNRLRNISRFFGHLLATDSISWAVMECIKLTEDDTTSSSRIFIKIMLGEMQESMGLKTITERFKDDEVQRCCGGMFPMDNPKNTRFAINYLTSIGLGPVTEEMREHLKNAPKLIMEQRRAMLEAESSSDSDSDSSDSDSDSDSGSDSSSGSDSSEDSRPRRRRSPSPPQNRRKREDSKSPPPRARRPSPSPPRRRDDGRDGDRYRSRRDSPPRRRDRSADRNERDRSPPHSPPHKSRYDARRLPSRSPSPPPRRGENISGRNGRDVRDDYDRKRADDHRSKDKPRDGDKDRDRDDYRARRRSPSRERYNGRDSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6RZW8</accession>
    <name>A0A2R6RZW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000115">
        <property type="protein sequence ID" value="PSS35573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6RZW8"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS35573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="330" mass="36221" checksum="D19982DD220D67ED" modified="2018-06-20" version="1" fragment="single">MSTPAANAASGSNDALRAAHNRLKFALWDDMEEARRRVLETRDERMEWLEDCFALLVRHTLSFPRDFVLIRGFCGQTRFEQMGGDWDNVPVRKFFDVVANAVQSLPNSSWAQRVIFEFPRIVEFFPGRRVPSEDTRPLSSAPELVTAPAVPLVPRPSVPRVTFAPLPPIAPPRTLPSPGTLVDPTFRLARTVSLPSRMIDPDHSPSGRALPGSAAYMIPDPPRPSVLHATLSRNRRPFAPPAPRIRRRVPRLPSSSPERAPVFAPVARFEPLAEGAAPVVDDDGEEEAASDGEEEVEVPPPAAKAAARGSKSEIRVHGGVSEDAEHCLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S399</accession>
    <name>A0A2R6S399_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v1382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthioribose kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S399"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34273">
        <property type="entry name" value="METHYLTHIORIBOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34273:SF2">
        <property type="entry name" value="METHYLTHIORIBOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="6">
        <location>
            <begin position="93"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSS36751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="281" mass="31098" checksum="F2C84E7EBDCCD27C" modified="2018-06-20" version="1">MAFDFSQFLQQVDPLDEYDIERLNGGLVNITIRAKKYARSTSSDDPGLFPGHSSLILKYAPPYIAAVGESAPFSQYRQVIEARALEFLASNEDILAAQRNCRVSIPKLLYMDIEQHVLVLEDLGSDLVILDEWLAPRPHSGRMEPGSASCNNVAARVGIFMAALHTLDVSPEVLDTFVNAATSNLVRNEIVGNIRNQLEQFQPLDWDADEVSLAIKTQFEEKGGKDVFSIGDFWTGSILVNADGSNICIVDWEFAGAGKPLQDMTQLGQRLNLYCFTVPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3F3</accession>
    <name>A0A2R6S3F3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v1380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000108">
        <property type="protein sequence ID" value="PSS36749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3F3"/>
    <dbReference type="STRING" id="98765.A0A2R6S3F3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="92"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSS36749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="275" mass="30700" checksum="39311D1479321930" modified="2018-06-20" version="1">MNSTAVRTSAVVGVLLLVLRYWTAKGKETRLITDFAEVGRRVKHEGEYNEDEYDVIIVGGGTAGCVLASRLSEDPTIRVLLLEAGQRFHYGAPSDYDEWAEIQKGQPGALGWTYKEFHPYFRKFEKYSPSREFPDVDVTLRGAEGLPTNGHLVGYHGYFSEITRKFVEACDAAGIARSHDVNTHKGTLGVTKGRRVTMETAYLTPDVLARPNLKVATGAFVNRILFDGNQDAPRAVGVEFNDKHGRTFRVKALKEVIVAYAIFALQGFYELMMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S3J6</accession>
    <name>A0A2R6S3J6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v1333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000107">
        <property type="protein sequence ID" value="PSS36789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S3J6"/>
    <dbReference type="STRING" id="98765.A0A2R6S3J6"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS36789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="161" mass="17900" checksum="03F628066F8152DF" modified="2018-06-20" version="1">MLHRDRPEKEYAPLYKKYDLGTTVWSALASGLLTGKYNNGVPEDSRFATHKDFFQKTLDTLDQEEGLAKIEKVKKLTKLAEEELGCNTAQLALAWVARHPTTSTVILGATKPAQVLDNLKAIEVIPKLTPEVLEKIEQILGNKPSPENTFGRPALDKFGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S443</accession>
    <name>A0A2R6S443_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v1136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000087">
        <property type="protein sequence ID" value="PSS37023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S443"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSS37023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="147" mass="16188" checksum="ECA157DD99FEEBBB" modified="2018-06-20" version="1">MNNPVHCLALYTSIIVSKMLPNIFNPFSGTRVPALPLAKTATVPEILHSVREVDLCNVPQNGHGEAVPFIFMRVPWASTSETALVLENHGQTSIVHLQHCTLTVCVKATQTRQKAILANLEADASKRQAVVYEKALRDYEAKNAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4E3</accession>
    <name>A0A2R6S4E3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v1024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000081">
        <property type="protein sequence ID" value="PSS37151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4E3"/>
    <dbReference type="OrthoDB" id="2679708at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015320716" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5265" checksum="1518F2A7ADDC683D" modified="2018-06-20" version="1">MRCASLAFIASSLVPSTFAATYGLIDNYVGSAFLSSFTHEAIADPTHGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4M7</accession>
    <name>A0A2R6S4M7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000070">
        <property type="protein sequence ID" value="PSS37238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S4M7"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="62086" checksum="891DCA397F6508C3" modified="2018-06-20" version="1">MPGGLHANGQWEEPPTARPESICNQTLAENAGEAPKPDTAYAWGKLLEEMESYDKKIVDTWRDELNNLLIFVAVILFLAGLLVLLYSVNIGIALAFTMVSGIPVLFFLIMTLIPLFLTRCPYKSPLIPTVLVVLKWCIFPVVLVVYVFAIFLLEPVRLAFHRTRISDTVNAVSEAFTTLFSHLAGMRGSLVVDIDRFWTDRELDRLTSRGHSLDPRAMSWALRALPRHRIALIKDCMRDFSQMESIFCVLLAAARSLGTSNIDFWNDSDFVHFSPFCPVNPRMLTRVNHQFKEQHRDSLLEVLPRDWSTGNWMISGKPAPDYRKRVPSILMLLWAIARHDLHSDFPVVFTKLLIPTLDHRLSVEQHREATRALRWAKEELDVVKELSIHTFTGEAQLDDYRLKINALEIVLGSSAIALLAVSQWPSIVQVNSPLRPLFCDFLDTLEEFIAQRKDDIRYVGHLCRAQPWDTTIVVTPRAVVTICKNLKRLEEKVILPVREHDCPSQRLTEHFGIICKDHRNVHLREAKLYVERPRRQDSSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S4V3</accession>
    <name>A0A2R6S4V3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000057">
        <property type="protein sequence ID" value="PSS37324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="98765.A0A2R6S4V3"/>
    <dbReference type="OrthoDB" id="3361281at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1497"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSS37324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1614" mass="177815" checksum="873EFE2577B604D7" modified="2018-06-20" version="1">MDSTEGIRRPTRTYGRSRKPDPEPDVDNTLGTVDASFAQSDLADASFSSTNSSPTYSISARDYPPDSDASSVFDYSMTRDDDDNDEAEADDAHEGEQEIRKSSSSSPGSSPAKDFKWDWRRELERLDKEAEQDDDDMEGAPRVGEAALEGEHGPSESDRSTRLERHSSSVAAVPAVDNISADDPFDGPLSAPTSSSQPHQHLSSPLPITRRSARRVILKESDKESEDEQVVLGANANEEARSSPQTSPDRLHHINTPPSATRSSPTPPTSQDMSSSRTKGKARAKQRKSTLRLSEDKEQDEDDESLPSGFRKNKETQGKSKGKGKEKATRVKPPTKKELLETQKATARIKADQQVAIPRTEKQLPLTALFAKFITAPSESRPRQSQSNDPTALSSDPIQSFSSSPVRPKSPPKRSLFTKPLLLLRRPPSPSNSRLRSKTVEQDDDVFGLKPTGLLGTSNPSASYSTRPSYGKAVSQKEEDNDVFGFASNGLLDGTATSVLPGPSHVFAAASSDEDEDMPEVSTIIRENQEKRAREERQKQLRELKMRALEQSKQSTSGNVSDSEDDGLEVVDDDMRVVAKEEEKDRRAMKAKHIRPSVGRKNQLIYAGRSPHKKKAEGKQDFQALIIAAAPSFSAQAQAQADKDKRHGVAPTRVGKNALNRILLMASEKQSKELTRQKEQEFYKRGGPSRGALRETDEGEKESLKRERLRMLAVKGLEAAQRREYGEQSEGEEEGDSGDDDWAPQGEVGSEDESDSQGGKENVATTEDDQPENEVPVATEDEDENEDTENVYHKPRRTLATRAFRPAVVDSDEDEENQGPLTSTQRFGRVLVPDTSLIIGSSSQGDSEPVLNDRHSVSSLEERTEDGTDKENDAGWMFDRGEDKENTAVASQYVSPSGRMPLRRGMSGSLFSLDSSLGLIGSPSSRRDAEVTLLEDERTPFKEIITAKEDEDEESFFLSPSSRPVRSIFTLSKHSTPAGPSRVLTPLPLSSPGGKGLDEFFSDDGAAEERGKNAEDELCGLEPAADIRPAFTQLFDDKTQSVSQLSALPQKLKAAGFSQFFTPEKSGSALQKLRPPQSSKDLSLTMDAQLQPALDVDENLLRKADDIFEKEQEFLLEDAVKAPPSQRSVYVNETGFLTQTRPSSSRKDRWALDTSPFFSESSPALQGLRSMMSTQRRPLGTLALSPIANRDADEDEDEAEVPRMGRLRKRRSTPELGKGKSGGYRSSASPSPPRRNIFEVLGRHPARAKVLQASKKKLEKSAFIEGEAEESDEDDGLAFGVRKKKDDDEEELDGEDQDGILEELVNDTAMDVETLNEAKVLEKVQEHRALDDAADEKLARDAAEGKLRTKRRDRGYDFENSESEDDDDPNAKYRRQKMSKKRKIDGDTLDALGKYDATKAFVQAYHAELEDDNEEFAHLENDDFSLTFVDRENERIDEGQDEDDENDEPEVVSAMQLQEELRKVARGEATVKTINPEDVSWMDPDNDMDDEGEDILVKEIATSRKPGRSAQSNQMDWDMLQKPQSGESTQDIARQQKWARTEGGSRNAGTGRASAVTGIGKSSKTGGGSVTATRKGPNPSGESSQARSGKQGARLSKAPSALSAVSSRRAKFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S575</accession>
    <name>A0A2R6S575_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000044">
        <property type="protein sequence ID" value="PSS37405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S575"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF10">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="4">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="198" mass="22301" checksum="E5947DD248196956" modified="2018-06-20" version="1">MVFSPRRLTEPGLAFSPFLVSITLKDPKGEPVRDAEIDWWQADTTGSYSYSTYNLRGKFYTNAEGQIQILTVIPGKYGPAGHLRAGHFHLIIRDKENKWQQLTSQLYVCQANDGAELGSDFLNFVRTPRTINVLQCWSIPSGEEKCMDFPELSSDELETIENVNRWNAMLADVDTSLKVVAGAQTEIHMNAKSGFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S5A1</accession>
    <name>A0A2R6S5A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000043">
        <property type="protein sequence ID" value="PSS37432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S5A1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSS37432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="269" mass="28597" checksum="76038161722FE66D" modified="2018-06-20" version="1">MSAVPTITSEPQLDAKIAAELQGPHVGMDIEPSEPQLPAEPVQGDAAPPANTRKVGLTVRFAAYTSIFICMSTFVGCMLAILFALRAITVTLVGFVLVTGYDYFTVGLPGFFVLNDSYLVHWQTAALGAGLIGFVCGPVVTLAMGGVAFVKRARGKLDEASKSEHMKMKRNFHSVVKAGCSFVFFDVALGALMLPVGSFASERYLSAFGEENLFMAAPVRCIAIGVLGGVVPRVISIMWKLAKGKKGGEIQLPADDLAKDSEKQPLPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6C9</accession>
    <name>A0A2R6S6C9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000030">
        <property type="protein sequence ID" value="PSS37793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6C9"/>
    <dbReference type="STRING" id="98765.A0A2R6S6C9"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="5">
        <location>
            <begin position="141"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSS37793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="293" mass="33239" checksum="2241F1A7961FA684" modified="2018-06-20" version="1">MTNCFIVELFVDASSHIGSVRSFKTAHNASFKPPLPESDTIQQLNSSNIIAKRLFIHQRLNESKPQDLTQPPRVKRVRMKAADELPRMLDEANCLFWGVALMRLVYDFVDHKLGKMSNSFLDGWDVPRLRFVLSGLAIPLSDTDAVYLIEERIPDTFTKYMINSSLKPMPNLDSAAMYIAEFLCFAQHVQYLKSEQRVFLSDFQGMSSDLNEYEGNFGAGNLSNMLKRFELEHQCNEFCEFFDLDCLVVADQQSADSESDDTTNNPEPDSNRRSSSSRPAPSASGPAVWRPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6L8</accession>
    <name>A0A2R6S6L8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v247</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000020">
        <property type="protein sequence ID" value="PSS37905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6L8"/>
    <dbReference type="STRING" id="98765.A0A2R6S6L8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSS37905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24992" checksum="D263912B22E2FAFE" modified="2018-06-20" version="1">MPPGPDGLPYLGNILQLTKTHWLRFSEWSEQYGGYEKHPGYLRLMTPPSTFRWRRFRRAAHEGFAGKSSLVYQPLQEKHAILLVSRIFQDLEGWDAELMRFAFISFTPETNNSIFGKCSACSVLSACYGWTVLDSTADDLIQRINDIPQRIGGPITSRPAAGMVQFFPWMLYLPEWLAKWKRRCRELHESDTKMLESFLDDFEKKPVCQWGHPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6S6N6</accession>
    <name>A0A2R6S6N6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PHLCEN_2v217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000016">
        <property type="protein sequence ID" value="PSS37960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6S6N6"/>
    <dbReference type="STRING" id="98765.A0A2R6S6N6"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="48"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PSS37960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="756" mass="79834" checksum="EE476EFCEF4553F2" modified="2018-06-20" version="1">MSPYVAPSTRAWKGKEREQPALLVRSGGEAGVVLPLDMLETSTYEAVYTIPLVVGSNQQSLSVQVDTGSSDLWIASTSCGTQACKQTGGRLYDPSHSTPTNKNFQISYVEGEVDGPIVWDTVQLGGYTIDSQALAAASTVNDEPLSGDFSGVLGLALPLNSVIEEQIRPTTNNAPDGAMLASNLFTMTPSSSTPESRFLSLSLERPGSSTIPSLIGVGQHPSQLVQDPSKIQYSPVASTSNGALWWQAHIWAVTVYVDGQPKQVTLSTSSSTRVSPTAVIDSGMPIIMASKSIADGIYGALGIGPASDGNYYLSCTTPINMTVTLDNRTAIALHPLDLSTPNSDSSCLGLIQAYPEGSEVANIADIVLGVPFMRSTYTVMAYDTPDSHGNFPNASAMPSPLINPSLGLLGLTNPTVALEEFHTVRVLNQPLPNGGQGNSGHTATAPTSGKKLSVGVEVLIGLLGFFGLCFLLFAARWAYYKRSMEQSGAKVIKDEVMMEDVAYRLARRSSYGSRYGPSEETLRAQKFGEYMQHQGEVKSMYADETGRTRVADDADVDNEKYTDAELGYRKVKVHSDSDSEGELTPPPGTTIFNTRSTRATLISPLAIDDNAVAAAAVQVLELPRPISTSDYPPSPSPSHHRLVSSEASVAMPLLAHTRSDSHISLRDSGTSGRVALGLGRPAGHARVGSDVSVRSANDGNGSGNGTNGRPPRLTRVPSGPRGVSPSLVPPPSLLNLGSHGVSQVSFSAETTNGHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NDK2</accession>
    <name>A0A2R6NDK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v13676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001351">
        <property type="protein sequence ID" value="PSR70425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NDK2"/>
    <dbReference type="STRING" id="98765.A0A2R6NDK2"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR70425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="475" mass="53434" checksum="9B9755A45331A909" modified="2018-06-20" version="1">MSAHPIAPAPFDIVAADVILRTSDNVDFYVYSVVLLLASLFFEAMFSSQAQRPVIHVPEDSRTLEDLLRFCYPVEDPVINDLLQVDLVLEAALKYDIAVAFKPLVKTLPGFVPTHSPQVYAIACRLGLEEVAKLAAVEWGKSTFDEYSPDFSGTMAGASYVPEMARIPAGTYYRLLFYLRTREEIPFCKPAPPKEPLFSDAQAPGGWPPFSDANTDIIIRSSDNIDFRAHTMIFGLPKGGSLLSQLMKDTHDSAVDGTPVLRMDADGEVLSEILIMCYPPGLTASRLESNDFGTFRRVIQTAQKYEMTAVIRVVKSIWKRGLEKEPLTMYLVAVACDWNDEAREALEYLATWPICDLYTVELEDTKADVYRGLLKRYHHLQGSMYQAMQPFAISPRSFFTPEVSVANGQWKQLWLTSSHGQPARTVPSLLLELEVKRGRKLGDRYSYNLADIMNTRHQLEVKLKQVVKNAVFEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE18</accession>
    <name>A0A2R6NE18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PHLCEN_2v13514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="MLYV02001346">
        <property type="protein sequence ID" value="PSR70605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE18"/>
    <dbReference type="STRING" id="98765.A0A2R6NE18"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PSR70605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="230" mass="25333" checksum="FE135C43B749F9ED" modified="2018-06-20" version="1">MGQTTSTASSPAVPITSSGKCPVPHTTTQASTSSGKCPIEHAPSGSQSSPTPAQCPIGHEGTEVNPRNQMPTLSQSPASNQSAQLPTDRTESSIPRDEASRWEYPSPQQFHNALVRKGWETPEEHVETMVQIHNFLNEQAWLEILKWEKKENPTEPPFDRHDWVVKRKTTGEEVRYVIDYYSAPPEQDGSPVFSLDVRPALDSFGSVKQRIAAATEDAWASVKADQTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NE47</accession>
    <name>A0A2R6NE47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v13515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02001346">
        <property type="protein sequence ID" value="PSR70606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NE47"/>
    <dbReference type="STRING" id="98765.A0A2R6NE47"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000009">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR70606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="14684" checksum="FD2DEE12027CFBF0" modified="2018-06-20" version="1">MSDGKAKSDSEWRAVLSPEQFRILRQKGTEPAGTGKFDKHYDEGVYTCAGCGTPLYKSTTKFKSGCGWPAFFDSIPGAVSRHTDNTMGMSRTEITCTACGGHLGHVFKGEGFPNPIDERHCVNSVSLNFAEENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NFU7</accession>
    <name>A0A2R6NFU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PHLCEN_2v12779</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001289">
        <property type="protein sequence ID" value="PSR71265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NFU7"/>
    <dbReference type="STRING" id="98765.A0A2R6NFU7"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="66"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PSR71265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="384" mass="41999" checksum="33B5E625A6C48253" modified="2018-06-20" version="1">MFRTSTSALVSLRISSRRLATHVSQSAPTTALGTRHDWSKKEIQDIYDSPLLDLIFRAAAVHRQYHDPKKIQLCTLMNIKTGGCSEDCSYCSQSSRYSTSTKASRLVEIEPVLEAARKAKANGSTRFCMGAAWRDLAGRKRGFEKILTMVSEVRGMGMEVCTTLGMLSPDQARQLKEAGLTAYNHNLDTSREFYPTVITTRSYDERLDTISAVRDAGISVCSGGILGLGESDADRVGLIYEVSSMPEHPESFPVNALVPIPGTPLENNEPIQYHTLLRTIATARVVLPSTIIRLAAGRQTLDEAKQAMCFMAGANAVFTGEQMLTTPCSPWDEDKTMMARWGLAGMRSFEQTNVARKEGSRLTASSEPVAESLSVSPAETQSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGC3</accession>
    <name>A0A2R6NGC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v12673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGC3"/>
    <dbReference type="STRING" id="98765.A0A2R6NGC3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR71406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="317" mass="35933" checksum="9E58879EF502C527" modified="2018-06-20" version="1">MVLDDMDICQLLPLRGDQYERGLSVPVDDRQWSHDRKMLLNHPHNQIDSFILYIKSTILMSHVKNFNLRFRGRYFAGDASMYSPSSSPASEPDRFDPRDTQAFQELDHYVTSFKGSFPAHMRNPVQDEMVDSYLYTAHCAAHLAQILLHEPHVRMSSSHDLSVGRVMKAARGILDLMYAISATSFDVSLLDHLPILCWNVCGRVLTKGLKAAVDKKDYEQSLVLQAEIAFVHSMLAKAGERMPLAYRYKQMVYEILLNTCGREYVQSLPENSYHRGGFTPPPSNASYDQTTYSAPVFAPAAYTMSTMQDGDGMARFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGD9</accession>
    <name>A0A2R6NGD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001285">
        <property type="protein sequence ID" value="PSR71416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGD9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR71416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="427" mass="46466" checksum="31DC57938C0E5D42" modified="2018-06-20" version="1">MASPKQRFNAVKDLPKSPSPHILTLESIRTTTVKPTKLANLTSRPLDTPKTPTIHLAVAKHATHTPSSVRSIRQTATPPPEDTRKPFVKARVAHSPRNAPLIGAAKISPTSVKPEVPKQAQTPAAHNKVVRQPLTPPQTPPPDIINKKASCRPRVTRVGRDGGVHDRKTAAAKVLVRPVVVKTKDHRTEAEFAARASGGARRALPVPLEVNKTASKRLQIAVVKKDCDSTPDRTMPTERSEPPATAIICVKPRAIVEELATYIPTKTDPKTPAIDIPKFVTEHAQPVLDNIEISVATNIDTITPIQPPEPAEIKAHAFELTLPVLEDGELKIDTAKQDLIAQLKLGLESRNLKQRLNERVVSGHEGASIVKTSSHDAQDAVAANQENKLVQERDRATTPIKSIITAPQEPKHMQANETGRRVARPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGT1</accession>
    <name>A0A2R6NGT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v12590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001272">
        <property type="protein sequence ID" value="PSR71539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGT1"/>
    <dbReference type="STRING" id="98765.A0A2R6NGT1"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR71539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="232" mass="24685" checksum="44BB806CAE52CCDC" modified="2018-06-20" version="1">MSYGGGYGGGGGYGGGYGGGAGAGYGPPPGAPPSYGGGGPGGFSAGPPQGPPPGADPQLWNWFAAVDTDRSGNISALELQKALINGDWTPFDLDTVKLLMSIFDTDRSGTIGFAEFAGLWKYIKDWQNVFRHFDRDHSGSIDGRELQQALGQFGYNLSPQLLHLVEKKYDVDKGSGPVAPGAPPAGITFDRFVRACVVIKTLTESFQRLDDNRDGWIQINYDQFMQTVLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NGZ2</accession>
    <name>A0A2R6NGZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v12510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NGZ2"/>
    <dbReference type="STRING" id="98765.A0A2R6NGZ2"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="407"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR71657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="979" mass="109785" checksum="62DBF2CF4CE3BE6D" modified="2018-06-20" version="1">MIYDKDGTPLQGITGGYGGDRRVDFIIPHSAVKKGKYEFVIESSCNGMFGVPWDGDTISPPDMNRYFGLSSADLCVPNQEAWGLLLDFTTLREISESLPGNTSLQNKALTVANEIMNVFDNNDLTSIGRARKTAQGVFGEGWEKKQEKIYQEGVKQPKVWGIGYCHIDTAWLWPYSVTQQKVARSWSTQVDLMERYPEHRFTCSQAQQFKWLEELYPRLFDRVKEKVKEGKFHLVGGAWVENDANMPSGEALARQFLYGQRYFESRFGKRCDTAWLPDSFGLTGALPQLIRLADMKYFFTQKLSCNVFPHSTFNWIGIDGSQVLCHMTPNLESSDVSLLVFGNGDGGGGPLSKMLENLRRIRAAGNESRELPPVDMGHSVEDFFDTVLKDTIGGTKLPNWNGELYLEFHRGTYTSHGSIKKGNRKSEILLRDVEHIATLASLYRYHKHDYVYPKSKIDVCWEKVLLNQFHDVLPGSAIGMVYDDAEKLYAEVRKDGEYLLEEAFGALFPKSLPLTSATVKAPGNIVAFNTTPFPRRDVVQVPLSPQMRSKVVQGSKDGLTGFALFDCSKGENLAHPTGFFADCMPVSVFTNNSDHFVLRNSSVQLTVSKGRITSLIDVQLERELITKGNTGGLVIFDDRPNYWDAWDVEIHHLETAHQLEFTDISVVADGPLRASIRSVIKYGKSNITVTISLDAIAATVKSNSRSLFIFDAIVDWHERHEFLKFELPLDIHNDNATYETQFGHVQRPTHKNTTWDMAKFEVCGHKFADLSEFGYGVAILSESKYGYSCRGNVLRISLLRAATAPDADQDQGMHTFSWAVMPHQGSFLESDVPVAAYLFNSPLHVRSIPQENVQYPLLQARAPFVVEGAPNIILETVKRGEDDDHKSGPTTVVLRLYEAFGGHVKANLRVASHIPVSKACITNLLEDETKQLRLFSGHEDTTSLKLDFHGFEVKTVKLWIGPPSTAGVGRYAYHTSRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHY9</accession>
    <name>A0A2R6NHY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v12536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001262">
        <property type="protein sequence ID" value="PSR71592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHY9"/>
    <dbReference type="STRING" id="98765.A0A2R6NHY9"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="47"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR71592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121646" checksum="08D6DC1C33C64ED6" modified="2018-06-20" version="1">MATMIPGGSNTHKPTTAEEERINMEKAVRKVLSDIANDKNRSNTQGWPEMAKTLRDVDEEKIKDTKEDIDTLLVFAGLFAAVLTPFLAETYQTLSEDPGDTSVAIQRHMSAQMSSYVLINGSLNSTVPAYPADEPSFVPPPFALSINVLWFASLALAVVTASFGILVKQWLREYMTIETSRGAKARLRVRQFRVTALDDWKVYEIAAVLPLLLQFSLGLFFVGLCFFSRSVHPTIGWTITSIVSAWGCLFFFAIFAPACSARCPYKTAVTKKAMRALRRLIYNCHLMPYFYFGPVKKSGFPMEDEDAATDAKGDVQILTAADAILLDDDLLVTTMSESLKGIQSSVAQAEVINFVVAALQQRSPASDPAPRPGNFLNLDRVPERTWTTLYEITAQTCSSSFPGEITDLEVWLQDAVMILSTSHPSRPPHFPEDVVETLTWCMTTAIVPTCRLIRDKQLLITIMSRSMAQIQSNPAEVIDAVVIALQQHLPASTPIIRPVVSLVLDGLPKEIWTELVKISAWILKRGPVLRRGSANGLEEWEKDAITILATFYPSTATFHPEAGGALTSCMIAAPVPTCQHIGSLLLTSDSSRDLLRRKYVGPSQWLSHILESFRGSISQLNIKDIPAKDVLQFIFRLVLAIPRLCDGTCTHDRDQHDLGELLFSHADDVPNSTISSILTEYRNRLSASEREADPQYVNLVAAADAALKDVDFLREALQEALQRSQHSYRMNCIAGVVRNWQRHATPSNRDTSILHFDNIPGDLWTMIMDYVQSFFDADFDADHTDWKGCVESAFIVLMSAPEDFTATEEGLRMLSRCISSLEDRQSKVVRLVLSLNVNPRRMRHEYYASIIERLSCTSPPTHFRLEETTLDAVSFIQSSVCNVACNHGSRLGEMYTAHQDQVPLFLRVAHFLMASATAAKTCLGDTSLSGLDALLIAIFSADASYKTRKQRLHIAISASACAMADIHVLDFTYRHLDARVLTSEETRFWCSSLSRLIGELEHFQTLRIQLEQDNVSFVEVAGKCLDLLGSQPDRSAIDTFLKAVSRSMYEHYELKDLIRALKAFIPEDKVSQYPILDALPEEEHIQNPIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NHZ4</accession>
    <name>A0A2R6NHZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v12108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001229">
        <property type="protein sequence ID" value="PSR72004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NHZ4"/>
    <dbReference type="STRING" id="98765.A0A2R6NHZ4"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="179" mass="19661" checksum="BD52D6054AA10F5E" modified="2018-06-20" version="1">MLEGTCLTETLKALLKEMQQNEERELENGETEGGMMAERASESDSDEEDDDDDAVGILEGPRLLGDVVLARRPDAPLTEDAVTPRCPDITGNVKVFHSAVAMFYAPSDLAGIGGMQRERIRATPSWHRGPGRYDCVYAEGDPTQPGFRGLLVGRARLFFSFKSGGTEYPCVLVQWFSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NI00</accession>
    <name>A0A2R6NI00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v12455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001259">
        <property type="protein sequence ID" value="PSR71602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NI00"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR71602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="50" mass="5155" checksum="26572EE16DC49EF5" modified="2018-06-20" version="1">MPVEATQYRVSSMAPLEDACCSAGLLQGSIAGGPSLLHEASDAHLVDFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJ63</accession>
    <name>A0A2R6NJ63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001188">
        <property type="protein sequence ID" value="PSR72425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJ63"/>
    <dbReference type="STRING" id="98765.A0A2R6NJ63"/>
    <dbReference type="OrthoDB" id="2717295at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="411"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR72425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="812" mass="93553" checksum="C534E0092C994EE1" modified="2018-06-20" version="1">MGKSVTVYNDQTHDRTIGKLITRTVELETEETRRRERNGPNRTQLPTHTLWAGDFNRHHLFWEREENTHLLTRAYLDAAEPLITALATFDLIQLLASKIPTLQANGTGNLMQPDNIFASPQLANHLITCNAHPALRPPNTDHFPVHTHLEHSYTISNEPPRWNWRKVEQADFYLALDDAVKTKEFPRKRIETREEFDRTLEHLTDALVEAREKTVPKIKPSPFVKRWWTADLVKTRTDVKRLARESYKRRTDVRHSIHAEYKRARNEYGESIRRAKKEHWEAFLEDIDGETIWNFSRYAASEHTDGGKTRIPQLQTKGTHRRTRLSKSNEEKSKALHETFFPPPGDTPPDQDTEEIPDQKFEFKGITRDLIREVIKKLKQYKAPGIDDFPNEVFIWCEDILVPILYYLFRATYELGFYPDLWKVLHTLVLRKPQRKDYTMPNAFRPIALLVCIAKILSACMARIPAIQTEKLSLLSNNHFLGRMGRTTTDSLHYITTTVKNAWRTHKVASILFLDVKAAFPSINPERLLYILRRKGIPKGIVDWLRLKMTDRRTVLCFDDFQSEQFLVESGLEQGCPLSVILYQYYNSDLLDLARKREGETATGNIDDVAIVAVADSFKRTHEILRSFMTRSGGAFQWSASHNSIFSVEKFGLINCLHALGDLGLPLKLGAGHPIIKPAKTHKFLGVLLDNKLRWHAQIEKAKDKGMQWLTHFRRMANVKHSISSRILQQLYFMIAIPSMLYVVDVFLTPIRTGAVSSTKRTGSVSAIQRLATVHRQAAMMMTGAMRTTATDVMEVHACILPFPLLVDKMCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJM0</accession>
    <name>A0A2R6NJM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="6">EF-Ts</shortName>
            <shortName evidence="6">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSF1</name>
        <name evidence="8" type="ORF">PHLCEN_2v11570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001153">
        <property type="protein sequence ID" value="PSR72577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJM0"/>
    <dbReference type="STRING" id="98765.A0A2R6NJM0"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="7">
        <location>
            <begin position="146"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR72577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="380" mass="41091" checksum="1744DFC6FAA986D6" modified="2018-06-20" version="1">MDEGGRKQELKRRQEDFAVSANQFEARSLETFDASATTMFKTRAATFLPSFRLYSTSQPTKPSIKLVAELRKLTEVSLSKAREALVASNNDVDAALKWLQEDLEVSGAKKAAKLEGRTTNEGLIGMSVLSSGVGSRTGRGSGGVRAAMVELNCETDFVARNDLFGKLLADIAHTAAYISEPADSVNLLKPCSLELLQEAPLLSQNGEQAETQSTVASAIRELVTKVGEKISLRRAATVVQDPLPRELGLRVASYSHGSVNIPSQGRIGALALIALKSPKLAELLASEPFREELIKLERSLARQIVGFSTTTIQSAAGATDEGALYQQPFMMYPDSNGDSVQATIRRWAEERGLREAGEVESGLEVLEFAKWTVGEPLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NJM5</accession>
    <name>A0A2R6NJM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001205">
        <property type="protein sequence ID" value="PSR72202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NJM5"/>
    <dbReference type="OrthoDB" id="3052275at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="26489" checksum="216E0C552D2D7C22" modified="2018-06-20" version="1">MQMAPGKHPKPDFATRRMADSTWDAEMSPVVIIGEAKQARTGQDVAGDRDTSKSYEAQMQAAVFPTLVLLILIYLKGNKHEPPLPKREGQSEEIEGEARPLPPNFFVYGVYYDERSVIIYSHFPYLEFENPGDSSDIGAWRFAQVKMGEFTLAHHDDGEQTNAPRRLKLGIALQGVHEHAVILENIFTAELPHLPVLQKVPLAPTRSSESTAKRSSSTGKSSTRTAGTGKLSSAKKSSAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKE0</accession>
    <name>A0A2R6NKE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PHLCEN_2v11370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">FBCC195</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MLYV02001136">
        <property type="protein sequence ID" value="PSR72771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKE0"/>
    <dbReference type="STRING" id="98765.A0A2R6NKE0"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="192"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PSR72771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="522" mass="58216" checksum="86BED7DE367922B5" modified="2018-06-20" version="1">MTVSENEPPPTSPQSLTLKRTLDTLQPCQETSSNSKEPSPTTPRTPKASLFFPARKLVLSKPDYHSLRSPLRIKIPQLFPGTTTIHVRGVPAASIASGSSSSESESESEGDSEDSSEDSSEEPTTPRASILSPRTSASIVTFSSPVSPNGFDDVSDLELGSLCIAERSYPSPSSNLPFSRRPPLRPACVGPFQFLRTLNKGSYGTAYAARDVSTSQVLCAKVCLKKRVREGKDFIRGMVTELRAYKRIAASEEGLRTWLMELHGVVQDPERVIFMMDLMETDLFAVLANPPQKRLVKRWLAQIALGIDALHSIGIIHRDIKPENILLSAASSDVRIRITDFTNSWIAPGDTADEWQRAYDVAPGSPLEWWRVYSKRYIGTKEYLAPEIRKKQWYGIMVDWWSLGCLAYDLIAGDALFPDDRSVNFYYKWEAEKTTSPYVLYRAGFLEEDEASMMSGSSYPYSCSHSALGGSDELAVHYTLEEEPMCYAAPEPYREDGMPASKAQVMFDQFGWINPNGMWAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NKT9</accession>
    <name>A0A2R6NKT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v11271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001127">
        <property type="protein sequence ID" value="PSR72858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NKT9"/>
    <dbReference type="STRING" id="98765.A0A2R6NKT9"/>
    <dbReference type="OrthoDB" id="4798501at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR72858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="109" mass="11589" checksum="25F3FF3B1A74EC71" modified="2018-06-20" version="1">MVLICAPSSGQRLNDTSLKQGAWDVLNSNTVGVWPPVTQIANLATNDAGQLSLNEYAVLAIAPELAPNSVAPNPADWDRSTLRSIAATVQLLRLSLKEDRNGSRGYSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL47</accession>
    <name>A0A2R6NL47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001122">
        <property type="protein sequence ID" value="PSR72978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL47"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR72978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="63" mass="7112" checksum="CF0114BF7974DC6E" modified="2018-06-20" version="1">MAPLISAREQRRSWTLKYYLALLPLVAASKPGETRTLQDQDFSNLGPFKTEDHKPEPVALPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NL51</accession>
    <name>A0A2R6NL51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Agmatinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v11022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001105">
        <property type="protein sequence ID" value="PSR73120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NL51"/>
    <dbReference type="STRING" id="98765.A0A2R6NL51"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11411" checksum="7EC7106EF5D2838A" modified="2018-06-20" version="1">MAPSGRPSPVLRITKTMTPLDSSESKRIDSIDPAFAPATGTPETGGWSTRELRTILRGLDGLHIVSADIVEVAPAYDTNAELTTMAAADVLYEVLSVMAKTPLGKVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLJ0</accession>
    <name>A0A2R6NLJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PHLCEN_2v10877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001094">
        <property type="protein sequence ID" value="PSR73262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLJ0"/>
    <dbReference type="STRING" id="98765.A0A2R6NLJ0"/>
    <dbReference type="OrthoDB" id="2794179at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PSR73262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1022" mass="115409" checksum="6E69F50BBFDF4C91" modified="2018-06-20" version="1">MADRRGVCRLYASGSCRYGNRCKFMHERGGNATQGLGENPGRLARGAATFRTGPVRPAGGVPRQACNLFWTTGSCNRSFECTFQHLREPNAAVGQGSATEKVPDEKDEEMLPDFFATEALAMENNAARQPQYTLGPTEAHNNIKPFLRDNYHFESAAKVQGFVKILASINDVNKAWYLASGLVLKSTLHKNINHLYTLMEGNYETIQDVIRKCIGGMIAEKSWMDPSLDGVVIFRTLSTVLLQYFNRFKDAIKNHPSIADLVMDISKWFETWATNVSCQPAGFQDVITTSDSKARGLRINKLREEIGRLTSIVLRESEHTEKLRRIHVNVGITSAQRRQVQIMQFAQTYDPPGGLRQDGPRHDNDFAEISQIRIAPTNDELLSPLAPYLPVFLADAPHHLAEHSMERHLDIQFRLLREELTCSIRASISAIYDDLGIIWRDVGVKKRQPTKLEEVIKKRGGPYKTSGFDSLFFYIYTNAQLSPVKAERCDLTVGLFLDTPAGTARSDDRKARYEYWEHGKRLQSRSLVALVLVTGGTMKVFLGVITSFGKDIAESSKVSADTVQIQISFFDPEVEFLALQSEKMTRDASSYAFLVDNSVMYEASRPFLERLQSIEPTEIPFARYISRGGSVADIQVLPPRYATAPRFKFKLQCLAKDRRQVINDLDISQPDAVATARRQLSQSSILDPSQVEAVASWDREGTCSGGYETSNSLKVVSFRRVSRLKKYYEFYSPAGSDPLVLLIAYTNHALDHMLTGVLDANITQKLIRLGPRSSDERIAEYTLDKLERVAAKSELDWSIGRQYGVMKELEERMTEVMESIQLPSLSWKDVEQFLGIHFPEHAEAFIAPPFWIAILAERLWADTDENGEWTTVKQSKQKTMEEGIFSRTFYGMWREGEDLKFISPSVQPAQQKKGRSKKAARPISPTPAPISSTTIDFFKQLGFPTLPPLPTTARATFNLLNIPTVWSMSLGERLRLSETWEQNIRTLAYENNLGEYTQLRASYKEACKDYNDIRDEAPSKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NLP3</accession>
    <name>A0A2R6NLP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v10893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001095">
        <property type="protein sequence ID" value="PSR73233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NLP3"/>
    <dbReference type="STRING" id="98765.A0A2R6NLP3"/>
    <dbReference type="OrthoDB" id="2507336at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR73233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="72" mass="8205" checksum="483043A40F6BCB7A" modified="2018-06-20" version="1">MSGTPKGNYGAPPKYLNDFSKALASEVRILLQEVGKLRDERRQLQQYASHRDRPDIVDLTLAASARYQNSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMA2</accession>
    <name>A0A2R6NMA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v11008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001104">
        <property type="protein sequence ID" value="PSR73152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMA2"/>
    <dbReference type="STRING" id="98765.A0A2R6NMA2"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="52" mass="5892" checksum="90844FBDC16DB9C5" modified="2018-06-20" version="1">MFGVNSEDSQVPMLNATSKSSALRHQFSDDGFDGSEESIVIQRVDRKEQVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMB9</accession>
    <name>A0A2R6NMB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001069">
        <property type="protein sequence ID" value="PSR73541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMB9"/>
    <dbReference type="STRING" id="98765.A0A2R6NMB9"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="243" mass="26697" checksum="9EB19D80B0C3B0D2" modified="2018-06-20" version="1">MHWLRSHKELRALESKVHLSSDSGASADPCAASNGIVIATEKKSSSILIDDSVIEKVAVICPNIGIVYSGMGPDFRVLVTKARKSAQAYWKIHGEYPPTKVLTQEIANIMQQATHSGGVRPYGVSLLVAGWDFPRGPTLYQVDPSGSFWAWKASAIGKNMVNAKTFLEKRYTDEISLEDAIHTALLTLKEGFEGQMTEKTIEIGVITVPSQAELEAGKVEGTGRYKPTFRKLTEEEVRDYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMU6</accession>
    <name>A0A2R6NMU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">NAD(P) transhydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Nicotinamide nucleotide transhydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PHLCEN_2v10449</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">FBCC195</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the C-terminal section; belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MLYV02001068">
        <property type="protein sequence ID" value="PSR73709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMU6"/>
    <dbReference type="STRING" id="98765.A0A2R6NMU6"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000028">
        <property type="entry name" value="NAD(P) transhydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000002">
        <property type="entry name" value="NAD(P) transhydrogenase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="862"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="26">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="25">
        <location>
            <begin position="230"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PSR73709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="1080" mass="112704" checksum="58342BA08663CF9C" modified="2018-06-20" version="1">MLDMRMVHCRYLGSLAKLRSPSGIQLKQGWLIMYWNSGDISFAIRDYRISASAWNEQQASVSSSTNGAPGKPEIIGTPYSSLTVGVPQEIYPNEHRVALTPQNASLLLKKGFARILVQKSAGAEAQFLDEQYRAAGAILVDRDEVFASSDILLKVRPPIFGEEAERVKEGSTVISFLYPNQNTEIVEALAARKATAFAMEMIPRISRAQVFDALSSMANIAGYKAVLEAANHFGRFLTGQVTAAGKIPPCKVLVIGAGVAGLSAIATARRMGAIVRGFDTRAAAREQVQSLGAEFLEVSIQESGEGGGGYAKIMSKEFIEAEMALFMEQAKDVDIIITTALIPGKPAPKLITEEMVSAMKQGSIVVDLAAETGGNCAVTKPGELYAYKGVTIIGYTDLPSRLPTQSSTLYSNNITKFLLSIGDEGKFGVNLGDEVVRGSIVLHNGTQLPPAPRPLPPPVVAPPTSKEAAEVVAITPWQRAKNEVATITAGMGTAVVLGKIAGPAFMSNFFTFGLAGMIGYRVVWGVAPALHSPLMSVTNAISGMVGIGGLYVMGGGYFPGTIPQVLGALSVLLASVNVAGGFVITKRMLDMFKRATDPPEYNWLYSIPAVVFTGGFLAAANTGMAGLAQAGYLTSSILCIASLSGLASQATARQGNILGILGVGSGIFASLAAVGFSPEVLVQFAAVAAMGGGVGTLLGRRITAIELPQMVAALHSVVGLAAVLTSIASVLADASHASTLHLVTAYLGVLIGGVTFTGSIVAFLKLAGKMSSRPLSLPGRHLINGSLLGANALTMGAFVTLAPTVPAVAAAYLGANAVLSFIKGFTTTAAIGGADMPVVITVLNAYSGFALVAEGFMLDNPLLTTVGSLIGVSGSILSYIMCVAMNRTLTNVLFGGLGTSVTQTDYKIEGSITKTSVDEAVDALNNAENVILVVGYGMAVAKAQYAIAEIVSVLRSRGINVRFAIHPVAGRMPGQCNVLLAEASVPYDIVLEMDEINDDFSDTDVTLVIGANDTVNPIALEPGSAIAGMPVLHAWKSKQVIVMKRGMSSGYADVPNPMFYMPGTKMLFGDAKDTCEGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NMY7</accession>
    <name>A0A2R6NMY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001066">
        <property type="protein sequence ID" value="PSR73745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NMY7"/>
    <dbReference type="STRING" id="98765.A0A2R6NMY7"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR73745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="423" mass="48100" checksum="0C50029967CD6696" modified="2018-06-20" version="1">MGILSRWSWPDIDGLKNFKGTLVHSANWDLGGATWEDDAKDWQDKNVAVIGLGSTALQIVAALHPKVGKLYNFGRGKAWISPPFAVTKFSELLSRDVFSDENYVFSEEEKERLDDPVFGRQFRHALEQDMNSLHTVTMRNSPLQQQVQVWFKAHMIHRLAKKPEIAEKLIPDFSVTCRRLTPAPGYLDALCQENVELIISDIEHVTSDTVETKDGNQTKLDVIICATGFDSSYRYPFPIIGRDGVDLCDKWTPTAKTYLSVCVDGFPNCFFGLGPNSTIGTGSLIPMIEHQVDYAVQVAMKLQRERLKSIEVKKRAVEDFDRFIETVFTEKVRTWYKLGKEEGRVVGLWPGSTLHALKALKYPRWEDFNYEQEDGESSHNSLYWLGNGMTNNEKTLTGDRAWYLSKEYMDVPSIPTATIKNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NN95</accession>
    <name>A0A2R6NN95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v10294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001052">
        <property type="protein sequence ID" value="PSR73874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NN95"/>
    <dbReference type="STRING" id="98765.A0A2R6NN95"/>
    <dbReference type="OrthoDB" id="10063670at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475">
        <property type="entry name" value="ZYGOTE-SPECIFIC CLASS V COPY B GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37475:SF1">
        <property type="entry name" value="ZYGOTE-SPECIFIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015305109" evidence="2">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR73874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="102" mass="9896" checksum="1F739FE30893CCE4" modified="2018-06-20" version="1">MNFKVLAAAVLAAVAPVANAGPIAYGICQTGMSPHNFIFLASRLIVSIGCNSVVVACYAGAGLTFGTIVAAPLAPAAALACNVALGTCSAACATVALFAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NNQ1</accession>
    <name>A0A2R6NNQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v10155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02001022">
        <property type="protein sequence ID" value="PSR74065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NNQ1"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="101" mass="10857" checksum="ED808636FB73F043" modified="2018-06-20" version="1">MTRPGAGSNQELGAPLYATLLYPTLGTRVIRTLPYPILAGLVFCYLPVGFAPALRPDQPQSILKFEEPQNQTHGLGSHCGSQAVQALRDAPLAMRRRGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NPL2</accession>
    <name>A0A2R6NPL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000989">
        <property type="protein sequence ID" value="PSR74416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NPL2"/>
    <dbReference type="STRING" id="98765.A0A2R6NPL2"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="431" mass="46829" checksum="58B68DC31C1200EC" modified="2018-06-20" version="1">MSSSSSPPLRRLSSTNSSSKESLINAYEAEEERIINILSRKLEQLREEKVELENALEAESESHVNRLSREISALRLAQQQAVNGNRLGSGSLSPVETRIPLGVVNPLEPTTEVMLEAMRRENEQLRNRLTETERDYIRISRLNDIYREELIDHRRRVGLPVDNLIGLAPSAIDPYSQPIHRRTSTSPYPVPQSLTTQSARVPIPRPPSQIHRPSQVPASVSISTTPPSSGSLSSPFIFSPPSGSMSAATNLTTPASSDSQGSFTGGPETLPRALELTYPSVPPPSLSSSFGDPLSMESPLLSPINGSQTAPAPMSIPRPIRRRGDRDISVSPVDTFNMAGARGPSLSPRASFHLARKASFERAWANDNVSPVRNRSRVRSTERGARVAETGTLVPVPRTSGSIRDTPVNGTTVTADERSIETVESASRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ14</accession>
    <name>A0A2R6NQ14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PHLCEN_2v9689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000975">
        <property type="protein sequence ID" value="PSR74623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ14"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ14"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PSR74623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="241" mass="25824" checksum="EC0EEA678FC577E0" modified="2018-06-20" version="1">MTIHDEMDVDRPSPLSEIYSVPSSSPHIPFNRLSLADERSYPQAQGVPSNSWSQHGTARPHPSYPDNARAASPAQVRNPTDAGRPASRQGQRNYPPYGHPSAIPRHIDPNALATSGYPYAASQPIPPNQYQAQQAVAGVSSGAGMSAHEALSADRSSSGRYECQWCGKGFTRPSSLKATYVCPFEGCGRSFSVQSNMRRHARVHTRAADASGELDEEEEESESASASNSASHSRGNSGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ95</accession>
    <name>A0A2R6NQ95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PHLCEN_2v9604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000961">
        <property type="protein sequence ID" value="PSR74725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ95"/>
    <dbReference type="STRING" id="98765.A0A2R6NQ95"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PSR74725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33770" checksum="C9A08284E00EA955" modified="2018-06-20" version="1">MASLNQVLAFLGVVVSIKCILGLVSFISLHCRPSRLHRFLHGREPYALITGASDGIGKAIAKELYSRGFNVILHGRDEQKLQAVKAEFRKGGSKAVKLWVADATSPEVDFDKAIEQWKDLHITLVIHNVGSARPKSERLDSIPAKVLMDDIYRNSLFPFFFTRAILPKLRQASGPAEMLYIGSFAGEGPMPYLTPYGATKSFLKQFSGSIGLDERSGIPSNVSTVYVTVGSVVSNSHKIGASLLSPTSEVYARSLVDKIGCGRKVLVPYLPHALQFWSTSVIPEWALDRFVEQVMEEEVKLWKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQ98</accession>
    <name>A0A2R6NQ98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v9656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000970">
        <property type="protein sequence ID" value="PSR74665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQ98"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR74665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="71" mass="7427" checksum="868F528666497017" modified="2018-06-20" version="1">MASGGLARGRGGKAPHPPLARSAKRAVRWAGLEWYPYHTTALTFSSRPCPTQPYPALASPSPRLGGGAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQH5</accession>
    <name>A0A2R6NQH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PHLCEN_2v9534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000956">
        <property type="protein sequence ID" value="PSR74820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQH5"/>
    <dbReference type="STRING" id="98765.A0A2R6NQH5"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PSR74820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="62" mass="6630" checksum="3E106AB1DC0D0117" modified="2018-06-20" version="1">MSSATAIAKLHSPVKELVEGATKEGSAEFGKSEKDKAEVTEWIERVAAGEAAKPENLKVLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NQN2</accession>
    <name>A0A2R6NQN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000954">
        <property type="protein sequence ID" value="PSR74854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NQN2"/>
    <dbReference type="STRING" id="98765.A0A2R6NQN2"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="218"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR74854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="297" mass="32650" checksum="0E2CA39008F165B2" modified="2018-06-20" version="1">MAGSFESRCYISSRSADVILSDVRPIKLKLEALRSINVFLDDFLHKILNAAGSLSTDSLKAGLNKILPTALGKEAVLEAELELKAYWERNTPHTPAKQEFDLQWSFELLRLKCEAYSTMNDGDEDLEAEKRLNKRMINAGGSSSPHNSLAAPAALYLTAILEHVLSNVGRVASRDSTRTVATVHNLFVALCEDSSMYSMFKGMKEQRDGITIGLVLDLVMFREDLKLCRTLDNTAPLSSATLQGISPGPCVQTDDDWDTWLATAFGTEYHPSCSCAMLLQNQGGVVDANLKVMVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NRJ3</accession>
    <name>A0A2R6NRJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Man1/Src1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PHLCEN_2v9465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">FBCC195</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000944">
        <property type="protein sequence ID" value="PSR74931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NRJ3"/>
    <dbReference type="STRING" id="98765.A0A2R6NRJ3"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PSR74931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="135" mass="15399" checksum="3796E8737F950D57" modified="2018-06-20" version="1">MGTITVRRRRARNLIENDRAGSLVQIALDLLRNQELAHHTDPITAPQPYLSSLQLRDLILQDEHSIRARSRLWERVERVVESNSNVRTNLEEVEGGDEMRVWRWVGSNAGTALSPGRTPARAYPHKTEQPDELAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS46</accession>
    <name>A0A2R6NS46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PHLCEN_2v9229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000910">
        <property type="protein sequence ID" value="PSR75263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS46"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PSR75263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="83" mass="9745" checksum="4F006361F7B8548D" modified="2018-06-20" version="1">MSETAPDSAEIIAELYVDLVEQTMIYAMCALATYEYIITFNQERTMIWRRKWSMVTWIFMANRYLLMSSTIWDVAPSTAELFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NS83</accession>
    <name>A0A2R6NS83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000880">
        <property type="protein sequence ID" value="PSR75731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NS83"/>
    <dbReference type="STRING" id="98765.A0A2R6NS83"/>
    <dbReference type="OrthoDB" id="2802092at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00811">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="316"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="591" mass="65215" checksum="E1833AEAAEB242BC" modified="2018-06-20" version="1">MPPSHETDPIYCEDLAHPGEGCLREFSNKKKAGLCNVCEALGTFDEEDNDAGRVNYARETAKAKRTEAFEARTNQQQKVATSVQSQANPLVAAIPHSDQALDTQSVRVARQASSGSNRNSGQGSGPPVRYITVQCDPKLNGKKTPEFGIRLASHSADTPMGESWNKGWEKKYSRGFELSDCDIRFKGNINIIRNTDSMTLGDFYDTHAQSSQRESYLGKDCDAKNKGKYQMLHLEIYINKELFLDRTVSASELQTQTSSKRRSAGSFAVPALPSKRGRSSVTAIHSTYTHRSSFDTPIEKATLVQLLYACCNVTKDSGEAEIIWPDSKSGKVVTGYLTNNKFAQGKTKAVYKFTPSDGKGSYVAKRHIDIGAGLNIVTIAENHLNLIAELRRLKLGQWFLDAFYQHARNLGASVSEASGLSESDIDISSDDSGAYWMVEPRRSSAVNRYSGTMNHPAARGKMQLTISAFEHFTFEHSDHNVVLADVQATPGMLPNDQGAGQILFDVMMHTPDGKSGVGDHGQEGIDVFLEQHQCQQFCHELQLGPLRIPRLNRTHAARLKSVEPATSADDEDNEEEDKEDELEPDELPGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSE1</accession>
    <name>A0A2R6NSE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endopolygalacturonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PHLCEN_2v8914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">FBCC195</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000879">
        <property type="protein sequence ID" value="PSR75797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSE1"/>
    <dbReference type="STRING" id="98765.A0A2R6NSE1"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PSR75797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="18794" checksum="6EAA960F1427D6EB" modified="2018-06-20" version="1" fragment="single">DGQGGNGGVTKPAPMMNTIKNQDDCLAINKGSNIVFQGNTCSGGHGISIVSNPAHPPLSHPPFHRDQALRIKTDSDATSASVTNVTYSGNTATGMRQFGILIDQGINFSGSKTSISVNSGAQRVAVNCGKGACTGLYLDFKPLAVAYIGVIWGTWDWSELSVTGGSAGEIVNFSGIENFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSE2</accession>
    <name>A0A2R6NSE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PHLCEN_2v8867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">FBCC195</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000875">
        <property type="protein sequence ID" value="PSR75818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSE2"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PSR75818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186601"/>
        </source>
    </evidence>
    <sequence length="170" mass="18548" checksum="775B2392EB4640C8" modified="2018-06-20" version="1">MSSGIIQVTEDGLLSTNEVLSEHTSRSSKETCSEGPSSPSSNMAKGKSPDVHADTSPHPKGNRYNLVVWETNWQKVLDYLYGKKRTLPKLISPNGPLPEFPRDINGQAAAARVLQLYVSEELVELMLTGDLEKKWLNAPAADPEDFILHGLAVTARGRKELGGTGVPMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-06-20" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2R6NSW1</accession>
    <name>A0A2R6NSW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PHLCEN_2v8719</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Hermanssonia centrifuga</name>
        <dbReference type="NCBI Taxonomy" id="98765"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Meruliaceae</taxon>
            <taxon>Hermanssonia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2018-02" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the basidiomycete white-rot fungus Phlebia centrifuga.</title>
            <authorList>
                <person name="Granchi Z."/>
                <person name="Peng M."/>
                <person name="de Vries R.P."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">FBCC195</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MLYV02000866">
        <property type="protein sequence ID" value="PSR76057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2R6NSW1"/>
    <dbReference type="STRING" id="98765.A0A2R6NSW1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000186601">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="262"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence
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